PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33982772-0	2021	LY-294002 enhances the chemosensitivity of liver cancer to oxaliplatin by blocking the PI3K/AKT/HIF-1alpha pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	AKT serine/threonine kinase 1	Homo sapiens	92-95
34036396-5	2021	Furthermore, the PI3K/AKT inhibitor LY294002 mirrored the effects of CD9 knockdown in SUP-B15 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	22-25
33982772-7	2021	The effects of LY-294002 and MK-2206 on the abnormal activation of PI3K/AKT pathway and hypoxia inducible factor (HIF)-1alpha protein level in HepG2R cells were detected using western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	AKT serine/threonine kinase 1	Homo sapiens	72-75
33982772-0	2021	LY-294002 enhances the chemosensitivity of liver cancer to oxaliplatin by blocking the PI3K/AKT/HIF-1alpha pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-106
33982772-9	2021	Compared with the AKT inhibitor MK2206, the PI3K inhibitor LY-294002 more effectively downregulated the phosphorylation levels of p85, p110alpha, p110beta, p110gamma and AKT in the PI3K/AKT pathway in HepG2R cells, and more effectively inhibited the proliferation of the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	AKT serine/threonine kinase 1	Homo sapiens	18-21
33982772-9	2021	Compared with the AKT inhibitor MK2206, the PI3K inhibitor LY-294002 more effectively downregulated the phosphorylation levels of p85, p110alpha, p110beta, p110gamma and AKT in the PI3K/AKT pathway in HepG2R cells, and more effectively inhibited the proliferation of the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	130-133
34036396-5	2021	Furthermore, the PI3K/AKT inhibitor LY294002 mirrored the effects of CD9 knockdown in SUP-B15 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	CD9 molecule	Homo sapiens	69-72
33848808-9	2021	And inhibition of PI3K/AKT pathway using LY294002 was accompanied by enhanced apoptosis and decreased autophagy which suggested that PI3K/AKT pathway promoted rMV-Hu191-induced autophagy and inhibited rMV-Hu191-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	23-26
33982772-9	2021	Compared with the AKT inhibitor MK2206, the PI3K inhibitor LY-294002 more effectively downregulated the phosphorylation levels of p85, p110alpha, p110beta, p110gamma and AKT in the PI3K/AKT pathway in HepG2R cells, and more effectively inhibited the proliferation of the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	135-144
33982772-9	2021	Compared with the AKT inhibitor MK2206, the PI3K inhibitor LY-294002 more effectively downregulated the phosphorylation levels of p85, p110alpha, p110beta, p110gamma and AKT in the PI3K/AKT pathway in HepG2R cells, and more effectively inhibited the proliferation of the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	146-154
33982772-9	2021	Compared with the AKT inhibitor MK2206, the PI3K inhibitor LY-294002 more effectively downregulated the phosphorylation levels of p85, p110alpha, p110beta, p110gamma and AKT in the PI3K/AKT pathway in HepG2R cells, and more effectively inhibited the proliferation of the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	156-165
33982772-9	2021	Compared with the AKT inhibitor MK2206, the PI3K inhibitor LY-294002 more effectively downregulated the phosphorylation levels of p85, p110alpha, p110beta, p110gamma and AKT in the PI3K/AKT pathway in HepG2R cells, and more effectively inhibited the proliferation of the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	AKT serine/threonine kinase 1	Homo sapiens	170-173
33982772-9	2021	Compared with the AKT inhibitor MK2206, the PI3K inhibitor LY-294002 more effectively downregulated the phosphorylation levels of p85, p110alpha, p110beta, p110gamma and AKT in the PI3K/AKT pathway in HepG2R cells, and more effectively inhibited the proliferation of the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	AKT serine/threonine kinase 1	Homo sapiens	170-173
33982772-11	2021	In addition, LY-294002 reduced the level of HIF-1alpha, which is highly expressed in HepG2R cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
33982772-12	2021	It was concluded that LY-294002 enhanced the chemosensitivity of liver cancer cells to oxaliplatin by inhibiting the PI3K/AKT signaling pathway, which may be related to the inhibition of HIF-1alpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-31	AKT serine/threonine kinase 1	Homo sapiens	122-125
33982772-12	2021	It was concluded that LY-294002 enhanced the chemosensitivity of liver cancer cells to oxaliplatin by inhibiting the PI3K/AKT signaling pathway, which may be related to the inhibition of HIF-1alpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	187-197
33848808-9	2021	And inhibition of PI3K/AKT pathway using LY294002 was accompanied by enhanced apoptosis and decreased autophagy which suggested that PI3K/AKT pathway promoted rMV-Hu191-induced autophagy and inhibited rMV-Hu191-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	138-141
33936270-14	2021	Studies for molecular mechanisms concluded that the apoptosis-inhibition effects and cardioprotective roles of PHLDA3 inhibition were induced partly by the activation of the PI3K/AKT pathway, which was verified by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	pleckstrin homology-like domain, family A, member 3	Rattus norvegicus	111-117
33737080-7	2021	LY294002 (PI3K inhibitor) and 740Y-P (PI3K agonist) were utilized to interfere with PI3k/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	89-92
33737080-13	2021	Furthermore, we found that GDF15 deficiency inhibited activation of the PI3K/Akt pathway, LY294002 treatment further enhanced the role of GDF15 suppression in inflammation and MUC5AC expression, while 740Y-P administration partly reversed the biological activities of GDF15 silencing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 1	Homo sapiens	77-80
33737080-13	2021	Furthermore, we found that GDF15 deficiency inhibited activation of the PI3K/Akt pathway, LY294002 treatment further enhanced the role of GDF15 suppression in inflammation and MUC5AC expression, while 740Y-P administration partly reversed the biological activities of GDF15 silencing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	growth differentiation factor 15	Homo sapiens	138-143
33737080-13	2021	Furthermore, we found that GDF15 deficiency inhibited activation of the PI3K/Akt pathway, LY294002 treatment further enhanced the role of GDF15 suppression in inflammation and MUC5AC expression, while 740Y-P administration partly reversed the biological activities of GDF15 silencing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	176-182
33737080-13	2021	Furthermore, we found that GDF15 deficiency inhibited activation of the PI3K/Akt pathway, LY294002 treatment further enhanced the role of GDF15 suppression in inflammation and MUC5AC expression, while 740Y-P administration partly reversed the biological activities of GDF15 silencing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	growth differentiation factor 15	Homo sapiens	138-143
33641073-10	2021	sc79 upregulated Cx43 expression, while LY294002 attenuated Cx43 upregulation by Ex-4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	gap junction protein, alpha 1	Mus musculus	60-64
33641073-5	2021	The mechanism underlying Cx43 regulation by Ex-4 was determined via treatment with either Src kinase inhibitor, KX2-391, Akt activator, sc79, or inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	gap junction protein, alpha 1	Mus musculus	25-29
33936270-14	2021	Studies for molecular mechanisms concluded that the apoptosis-inhibition effects and cardioprotective roles of PHLDA3 inhibition were induced partly by the activation of the PI3K/AKT pathway, which was verified by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
33846811-4	2021	At the molecular level, LY294002 and ABT199 combination treatment significantly downregulated Skp2, Bcl2, procaspase-3 and procaspase-9 expression levels, but markedly upregulated p27, Bax, cleaved caspase-3 and caspase-9 expression levels in K562, HL-60 and KG1a cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	S-phase kinase associated protein 2	Homo sapiens	94-98
33403593-11	2021	Both LY294002 and betulinic acid reversed the protective effect of IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	insulin-like growth factor 1	Rattus norvegicus	67-72
33899114-10	2021	Additionally, further activation of the PI3K/AKT signaling pathway by IGF-1 inhibited the beneficial effects of mangiferin on RRCECs, whereas deactivation of the PI3K/AKT signaling pathway by LY294002 displayed the opposite results.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	192-200	AKT serine/threonine kinase 1	Rattus norvegicus	167-170
33738663-10	2021	Furthermore, CK activated MEK/ERK1/2 and PI3K/AKT pathways, and the beneficial effects of CK on primary Schwann cells and RSC96 cells were distinctly suppressed by inhibitor PD98059 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	mitogen activated protein kinase 3	Rattus norvegicus	30-36
33846811-4	2021	At the molecular level, LY294002 and ABT199 combination treatment significantly downregulated Skp2, Bcl2, procaspase-3 and procaspase-9 expression levels, but markedly upregulated p27, Bax, cleaved caspase-3 and caspase-9 expression levels in K562, HL-60 and KG1a cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	BCL2 apoptosis regulator	Homo sapiens	100-104
33846811-4	2021	At the molecular level, LY294002 and ABT199 combination treatment significantly downregulated Skp2, Bcl2, procaspase-3 and procaspase-9 expression levels, but markedly upregulated p27, Bax, cleaved caspase-3 and caspase-9 expression levels in K562, HL-60 and KG1a cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	caspase 3	Homo sapiens	106-118
33846811-4	2021	At the molecular level, LY294002 and ABT199 combination treatment significantly downregulated Skp2, Bcl2, procaspase-3 and procaspase-9 expression levels, but markedly upregulated p27, Bax, cleaved caspase-3 and caspase-9 expression levels in K562, HL-60 and KG1a cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	dynactin subunit 6	Homo sapiens	180-183
33846811-4	2021	At the molecular level, LY294002 and ABT199 combination treatment significantly downregulated Skp2, Bcl2, procaspase-3 and procaspase-9 expression levels, but markedly upregulated p27, Bax, cleaved caspase-3 and caspase-9 expression levels in K562, HL-60 and KG1a cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	BCL2 associated X, apoptosis regulator	Homo sapiens	185-188
33846811-4	2021	At the molecular level, LY294002 and ABT199 combination treatment significantly downregulated Skp2, Bcl2, procaspase-3 and procaspase-9 expression levels, but markedly upregulated p27, Bax, cleaved caspase-3 and caspase-9 expression levels in K562, HL-60 and KG1a cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	caspase 3	Homo sapiens	109-118
33846811-4	2021	At the molecular level, LY294002 and ABT199 combination treatment significantly downregulated Skp2, Bcl2, procaspase-3 and procaspase-9 expression levels, but markedly upregulated p27, Bax, cleaved caspase-3 and caspase-9 expression levels in K562, HL-60 and KG1a cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	caspase 9	Homo sapiens	126-135
34057012-6	2021	The protein expressions of PI3K/AKT pathway associated factors were detected after overexpression of miR-2053 or administration with the pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	AKT serine/threonine kinase 1	Homo sapiens	32-35
33881516-7	2021	Rescue experiments found that the PI3K/AKT inhibitor LY294002 reversed the effects of FN1-siRNA on apoptosis and autophagy in HUVECs cultured in serum from patients with PE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	39-42
33881516-7	2021	Rescue experiments found that the PI3K/AKT inhibitor LY294002 reversed the effects of FN1-siRNA on apoptosis and autophagy in HUVECs cultured in serum from patients with PE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	fibronectin 1	Homo sapiens	86-89
34020670-7	2021	LY294002 inhibited the biological function of HUVECs through inhibition of the PI3K/AKT/eNOS pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	84-87
34052845-7	2021	In vitro, knocking down the Atg5 gene or using autophagy inhibitors (3-MA, LY294002) to inhibit autophagy was found to repress osteoclastogenesis and decrease expression of the osteoclast-related genes TRAP, cathepsin K, and matrix metalloprotein 9 (MMP-9) with or without titanium (Ti) particles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	autophagy related 5	Homo sapiens	28-32
34052845-7	2021	In vitro, knocking down the Atg5 gene or using autophagy inhibitors (3-MA, LY294002) to inhibit autophagy was found to repress osteoclastogenesis and decrease expression of the osteoclast-related genes TRAP, cathepsin K, and matrix metalloprotein 9 (MMP-9) with or without titanium (Ti) particles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	TRAP	Homo sapiens	202-206
34052845-7	2021	In vitro, knocking down the Atg5 gene or using autophagy inhibitors (3-MA, LY294002) to inhibit autophagy was found to repress osteoclastogenesis and decrease expression of the osteoclast-related genes TRAP, cathepsin K, and matrix metalloprotein 9 (MMP-9) with or without titanium (Ti) particles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	cathepsin K	Homo sapiens	208-219
34052845-7	2021	In vitro, knocking down the Atg5 gene or using autophagy inhibitors (3-MA, LY294002) to inhibit autophagy was found to repress osteoclastogenesis and decrease expression of the osteoclast-related genes TRAP, cathepsin K, and matrix metalloprotein 9 (MMP-9) with or without titanium (Ti) particles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	matrix metallopeptidase 9	Homo sapiens	225-248
34052845-7	2021	In vitro, knocking down the Atg5 gene or using autophagy inhibitors (3-MA, LY294002) to inhibit autophagy was found to repress osteoclastogenesis and decrease expression of the osteoclast-related genes TRAP, cathepsin K, and matrix metalloprotein 9 (MMP-9) with or without titanium (Ti) particles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	matrix metallopeptidase 9	Homo sapiens	250-255
34052845-8	2021	In vivo, 3-MA and LY294002 repressed Ti particle-stimulated osteolysis and osteoclastogenesis and reduced expression of the pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	tumor necrosis factor	Homo sapiens	149-158
34052845-8	2021	In vivo, 3-MA and LY294002 repressed Ti particle-stimulated osteolysis and osteoclastogenesis and reduced expression of the pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	interleukin 1 alpha	Homo sapiens	160-168
34052845-8	2021	In vivo, 3-MA and LY294002 repressed Ti particle-stimulated osteolysis and osteoclastogenesis and reduced expression of the pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	interleukin 6	Homo sapiens	174-178
34038756-8	2021	Expectedly, inhibition of Akt signaling with LY294002 obviously enhanced As3+-triggered autophagy and apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	thymoma viral proto-oncogene 1	Mus musculus	26-29
34031457-6	2021	Pre-treatment with IGF-1 signal pathway specific inhibitors such as picropodophyllin, LY294002, and rapamycin attenuated EE induced myotube hypertrophy and MyHC isoform overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	insulin-like growth factor 1	Mus musculus	19-24
34031457-6	2021	Pre-treatment with IGF-1 signal pathway specific inhibitors such as picropodophyllin, LY294002, and rapamycin attenuated EE induced myotube hypertrophy and MyHC isoform overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	myosin heavy chain, cardiac muscle complex	Mus musculus	156-160
34020670-7	2021	LY294002 inhibited the biological function of HUVECs through inhibition of the PI3K/AKT/eNOS pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 3	Homo sapiens	88-92
34001063-8	2021	Furthermore, the insulin receptor beta was stimulated with insulin treatment, subsequently, the phosphorylation of AKT and mTOR was positively activated, which was adversely suppressed in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	204-212	insulin	Homo sapiens	17-24
33997938-8	2022	The expression of pp65, pAKT and MMP2 in sh-ADAMTS18 was down-regulated after being treated with PDTC (NF-kappa B inhibitor) and LY294002 (AKT inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	matrix metallopeptidase 2	Homo sapiens	33-37
33997938-8	2022	The expression of pp65, pAKT and MMP2 in sh-ADAMTS18 was down-regulated after being treated with PDTC (NF-kappa B inhibitor) and LY294002 (AKT inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	ADAM metallopeptidase with thrombospondin type 1 motif 18	Homo sapiens	44-52
33997938-8	2022	The expression of pp65, pAKT and MMP2 in sh-ADAMTS18 was down-regulated after being treated with PDTC (NF-kappa B inhibitor) and LY294002 (AKT inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	AKT serine/threonine kinase 1	Homo sapiens	25-28
34001063-8	2021	Furthermore, the insulin receptor beta was stimulated with insulin treatment, subsequently, the phosphorylation of AKT and mTOR was positively activated, which was adversely suppressed in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	204-212	AKT serine/threonine kinase 1	Homo sapiens	115-118
34001063-8	2021	Furthermore, the insulin receptor beta was stimulated with insulin treatment, subsequently, the phosphorylation of AKT and mTOR was positively activated, which was adversely suppressed in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	204-212	mechanistic target of rapamycin kinase	Homo sapiens	123-127
34001063-10	2021	Furthermore, the effect of insulin on PM-related proteins was restored with the addition of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	insulin	Homo sapiens	27-34
33737010-12	2021	P13/Akt pathway inhibitor LY294002 inhibited the proliferation of CRC cells, and the P13/Akt signaling was required for BzATP induced the proliferation of CRC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	4-7
33999329-10	2021	Meanwhile, treatment with Akt inhibitor LY294002 reversed the protective effects of isorhamnetin against HG-aggravated OGD/R injury in HT22 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	thymoma viral proto-oncogene 1	Mus musculus	26-29
33989758-5	2021	In order to clarify, we showed that the phosphatidylinositol 3-kinase inhibitor, LY294002, inhibited FLC-induced Akt-mediated deactivation of Forkhead box O class 3a (FoxO3a) and increased catalase activity in proximal tubule cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	113-116
33989758-5	2021	In order to clarify, we showed that the phosphatidylinositol 3-kinase inhibitor, LY294002, inhibited FLC-induced Akt-mediated deactivation of Forkhead box O class 3a (FoxO3a) and increased catalase activity in proximal tubule cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	forkhead box O3	Homo sapiens	167-173
33989758-5	2021	In order to clarify, we showed that the phosphatidylinositol 3-kinase inhibitor, LY294002, inhibited FLC-induced Akt-mediated deactivation of Forkhead box O class 3a (FoxO3a) and increased catalase activity in proximal tubule cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	catalase	Homo sapiens	189-197
33978262-9	2021	The PI3K/AKT inhibitor LY294002 and ERK1/2 inhibitor SCH772984 inhibited the VE-induced granulosa cell proliferation and promoted apoptosis, whereas the p38 inhibitor SB203580 had the opposite effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Bos taurus	9-12
33978262-11	2021	The results also showed that the PI3K/AKT inhibitor LY294002 and ERK1/2 inhibitor SCH772984 inhibited VE-induced NRF2, GCLC, GCLM, and HO-1 expression, whereas the p38 inhibitor SB203580 not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Bos taurus	38-41
33978262-11	2021	The results also showed that the PI3K/AKT inhibitor LY294002 and ERK1/2 inhibitor SCH772984 inhibited VE-induced NRF2, GCLC, GCLM, and HO-1 expression, whereas the p38 inhibitor SB203580 not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	NFE2 like bZIP transcription factor 2	Bos taurus	113-117
33978262-11	2021	The results also showed that the PI3K/AKT inhibitor LY294002 and ERK1/2 inhibitor SCH772984 inhibited VE-induced NRF2, GCLC, GCLM, and HO-1 expression, whereas the p38 inhibitor SB203580 not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	glutamate-cysteine ligase catalytic subunit	Bos taurus	119-123
33978262-11	2021	The results also showed that the PI3K/AKT inhibitor LY294002 and ERK1/2 inhibitor SCH772984 inhibited VE-induced NRF2, GCLC, GCLM, and HO-1 expression, whereas the p38 inhibitor SB203580 not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	glutamate-cysteine ligase modifier subunit	Bos taurus	125-129
33978262-11	2021	The results also showed that the PI3K/AKT inhibitor LY294002 and ERK1/2 inhibitor SCH772984 inhibited VE-induced NRF2, GCLC, GCLM, and HO-1 expression, whereas the p38 inhibitor SB203580 not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	heme oxygenase 1	Bos taurus	135-139
33978262-11	2021	The results also showed that the PI3K/AKT inhibitor LY294002 and ERK1/2 inhibitor SCH772984 inhibited VE-induced NRF2, GCLC, GCLM, and HO-1 expression, whereas the p38 inhibitor SB203580 not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	mitogen-activated protein kinase 14	Bos taurus	164-167
34046062-15	2021	Rescue experiments showed that PI3K inhibitor (LY294002) could reverse the phenomenon caused by NOLC1 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	96-101
33964145-7	2021	The RA-induction of SHARP-2 mRNA level was mainly inhibited by LY294002, staurosporine, and actinomycin D, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	basic helix-loop-helix family, member e40	Rattus norvegicus	20-27
33959949-8	2021	Inhibition of phosphoinositide 3-Kinase (PI-3K) with LY294002 (25 microM) significantly potentiated an inhibitory effect of bFGF on TEER indicating that PI-3K signalling pathway counteracts bFGF modulation of TEER.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	14-39
33959949-8	2021	Inhibition of phosphoinositide 3-Kinase (PI-3K) with LY294002 (25 microM) significantly potentiated an inhibitory effect of bFGF on TEER indicating that PI-3K signalling pathway counteracts bFGF modulation of TEER.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	fibroblast growth factor 2	Homo sapiens	124-128
33959949-8	2021	Inhibition of phosphoinositide 3-Kinase (PI-3K) with LY294002 (25 microM) significantly potentiated an inhibitory effect of bFGF on TEER indicating that PI-3K signalling pathway counteracts bFGF modulation of TEER.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	fibroblast growth factor 2	Homo sapiens	190-194
33961854-13	2021	Inhibition of this pathway by PI3K inhibitor LY294002 obstructed the impact of ADORA1 on tumor development in cells with ADORA1-overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	adenosine A1 receptor	Mus musculus	79-85
33961854-13	2021	Inhibition of this pathway by PI3K inhibitor LY294002 obstructed the impact of ADORA1 on tumor development in cells with ADORA1-overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	adenosine A1 receptor	Mus musculus	121-127
33495943-8	2021	The mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) inhibitor U0126 or the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 reduced CYP3A4 mRNA levels of THLE-5b cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	117-146
33404163-6	2021	Mechanistically, the oncogenic effects of Girdin could be reversed by LY294002 (an AKT pathway inhibitor) and Metformin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	coiled-coil domain containing 88A	Homo sapiens	42-48
33404163-6	2021	Mechanistically, the oncogenic effects of Girdin could be reversed by LY294002 (an AKT pathway inhibitor) and Metformin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Homo sapiens	83-86
33069631-8	2021	Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
33069631-8	2021	Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	forkhead box O1	Rattus norvegicus	99-104
33069631-9	2021	Furthermore, saponins increased the protein level of the downstream molecule and insulin initiating factor PDX-1, which was also reversed by ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	pancreatic and duodenal homeobox 1	Rattus norvegicus	107-112
33069631-10	2021	Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	forkhead box O1	Rattus norvegicus	57-62
33627540-12	2021	In addition, further studies have shown that treatment with LY294002 enhanced the effects of ARG on the expression of proteins associated with apoptosis and autophagy , indicating that ARG may induce apoptosis and autophagy through PI3K/Akt/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	93-96
33627540-12	2021	In addition, further studies have shown that treatment with LY294002 enhanced the effects of ARG on the expression of proteins associated with apoptosis and autophagy , indicating that ARG may induce apoptosis and autophagy through PI3K/Akt/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	185-188
33627540-12	2021	In addition, further studies have shown that treatment with LY294002 enhanced the effects of ARG on the expression of proteins associated with apoptosis and autophagy , indicating that ARG may induce apoptosis and autophagy through PI3K/Akt/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	237-240
33627540-12	2021	In addition, further studies have shown that treatment with LY294002 enhanced the effects of ARG on the expression of proteins associated with apoptosis and autophagy , indicating that ARG may induce apoptosis and autophagy through PI3K/Akt/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	mechanistic target of rapamycin kinase	Homo sapiens	241-245
33747186-8	2021	FK18 also increased the Bcl-2/Bax ratio and decreased the level of cleaved-caspase-3 in SY5Y cells, which was reversed by the Akt pathway inhibitor LY294002, but not by the Erk pathway inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Homo sapiens	126-129
33495943-8	2021	The mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) inhibitor U0126 or the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 reduced CYP3A4 mRNA levels of THLE-5b cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	181-187
33607158-8	2021	Mechanism studies revealed that XQ-1H exerted angiogenesis promoting effect via the PI3K/Akt/GSK3beta/beta-catenin/VEGF signal pathway, which was reversed by LY294002 (the specific inhibitor of PI3K/Akt).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	thymoma viral proto-oncogene 1	Mus musculus	89-92
33760144-15	2021	LY294002 pre-treatment also significantly downregulated the TNF-alpha, IL-6 and IL-8 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Mus musculus	60-69
33760144-15	2021	LY294002 pre-treatment also significantly downregulated the TNF-alpha, IL-6 and IL-8 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 6	Mus musculus	71-75
33760144-15	2021	LY294002 pre-treatment also significantly downregulated the TNF-alpha, IL-6 and IL-8 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	chemokine (C-X-C motif) ligand 15	Mus musculus	80-84
33607158-8	2021	Mechanism studies revealed that XQ-1H exerted angiogenesis promoting effect via the PI3K/Akt/GSK3beta/beta-catenin/VEGF signal pathway, which was reversed by LY294002 (the specific inhibitor of PI3K/Akt).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	glycogen synthase kinase 3 alpha	Mus musculus	93-101
33559827-10	2021	Meanwhile, these effects can be suppressed by LY294002, a specific inhibitor of PI3K/AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
33607158-8	2021	Mechanism studies revealed that XQ-1H exerted angiogenesis promoting effect via the PI3K/Akt/GSK3beta/beta-catenin/VEGF signal pathway, which was reversed by LY294002 (the specific inhibitor of PI3K/Akt).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	catenin (cadherin associated protein), beta 1	Mus musculus	102-114
33607158-8	2021	Mechanism studies revealed that XQ-1H exerted angiogenesis promoting effect via the PI3K/Akt/GSK3beta/beta-catenin/VEGF signal pathway, which was reversed by LY294002 (the specific inhibitor of PI3K/Akt).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	vascular endothelial growth factor A	Mus musculus	115-119
33607158-8	2021	Mechanism studies revealed that XQ-1H exerted angiogenesis promoting effect via the PI3K/Akt/GSK3beta/beta-catenin/VEGF signal pathway, which was reversed by LY294002 (the specific inhibitor of PI3K/Akt).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	thymoma viral proto-oncogene 1	Mus musculus	199-202
33906701-9	2021	Culture in 1 ng/ml leptin with LY294002 decreased the normal follicles and increased apoptosis, inhibited follicle activation (P < 0.05), and reduced p-Akt immunostaining, compared with the medium containing 1 ng/ml leptin without PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	leptin	Homo sapiens	19-25
33930632-9	2021	Interestingly, we also detected that the addition of LY294002 and Rapamycin inhibited the PI3K/Akt pathway and the mTOR pathway, respectively, resulting in changes in both apoptosis and autophagy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Bos taurus	95-98
33930632-9	2021	Interestingly, we also detected that the addition of LY294002 and Rapamycin inhibited the PI3K/Akt pathway and the mTOR pathway, respectively, resulting in changes in both apoptosis and autophagy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	mechanistic target of rapamycin kinase	Bos taurus	115-119
33906701-9	2021	Culture in 1 ng/ml leptin with LY294002 decreased the normal follicles and increased apoptosis, inhibited follicle activation (P < 0.05), and reduced p-Akt immunostaining, compared with the medium containing 1 ng/ml leptin without PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	leptin	Homo sapiens	216-222
33914271-9	2021	LY294002 attenuated the myocardial protective effect of DEX, indicating that Dex protected against cardiac I/R by activating the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	134-137
33906701-9	2021	Culture in 1 ng/ml leptin with LY294002 decreased the normal follicles and increased apoptosis, inhibited follicle activation (P < 0.05), and reduced p-Akt immunostaining, compared with the medium containing 1 ng/ml leptin without PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	152-155
33986917-6	2021	These beneficial effects of SPostC were abolished by either TOPK kinase inhibitor HI-TOPK-032 or PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	thymoma viral proto-oncogene 1	Mus musculus	102-105
33895847-8	2021	The protein markers (Col-I, Fibronectin and alpha-smooth muscle actin) of collagen deposition up-regulated by NiO NPs were reduced by 10 muM PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	fibronectin 1	Rattus norvegicus	28-39
33895847-8	2021	The protein markers (Col-I, Fibronectin and alpha-smooth muscle actin) of collagen deposition up-regulated by NiO NPs were reduced by 10 muM PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	actin gamma 2, smooth muscle	Rattus norvegicus	44-69
33705930-8	2021	LY294002 administration further enhanced the effect of ErbB2 silencing on the expression of nestin, MAP2, GFAP and cleaved-caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	erb-b2 receptor tyrosine kinase 2	Rattus norvegicus	55-60
33705930-8	2021	LY294002 administration further enhanced the effect of ErbB2 silencing on the expression of nestin, MAP2, GFAP and cleaved-caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nestin	Rattus norvegicus	92-98
33705930-8	2021	LY294002 administration further enhanced the effect of ErbB2 silencing on the expression of nestin, MAP2, GFAP and cleaved-caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	microtubule-associated protein 2	Rattus norvegicus	100-104
33705930-8	2021	LY294002 administration further enhanced the effect of ErbB2 silencing on the expression of nestin, MAP2, GFAP and cleaved-caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glial fibrillary acidic protein	Rattus norvegicus	106-110
33902663-10	2021	Moreover, the curculigoside group exhibited increased biomineralization, ALP activity, and ARS staining compared to the induced and control groups, and these effects were partially inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	secreted Ly6/Plaur domain containing 1	Mus musculus	91-94
33902663-12	2021	PCR and western blot analysis showed that the expression of RUNX2, ALP, and Osterix was upregulated in curculigoside-treated ADSCs, but this effect was partially reversed by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	runt related transcription factor 2	Mus musculus	60-65
33902663-12	2021	PCR and western blot analysis showed that the expression of RUNX2, ALP, and Osterix was upregulated in curculigoside-treated ADSCs, but this effect was partially reversed by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	Sp7 transcription factor 7	Mus musculus	76-83
33981385-7	2021	Activation of suppressed nuclear Nrf2 and reduced antioxidant genes across cells interacting with an LY294002 confirmed this phenomenon.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
33924188-4	2021	To examine neuroprotection by salicin, gerbils were pretreated with salicin alone or together with LY294002, which is a phosphatidylinositol 3-kinase (PI3K) inhibitor, once daily for 3 days before TI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	120-149
33878031-4	2021	Zileuton and LY294002 were used to inhibit expression of 5-LOX and Akt, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	67-70
33878031-7	2021	Zileuton also upregulated activated (phosphorylated) AKT levels, and these beneficial effects of Zileuton were abolished by intracerebroventricular infusion of the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	AKT serine/threonine kinase 1	Rattus norvegicus	53-56
33864097-4	2021	This protective effect was reversed after co-treatment with PI3K and Akt inhibitors, LY294002 and SH-6, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Rattus norvegicus	69-72
33887379-7	2021	Furthermore, the PI3K inhibitor (LY294002 or 3-MA) and/or PAP reversed the Cd-induced upregulated expression of LC3 II, Beclin-1, and PI3K class III, with a synergy between PI3K inhibitor and PAP against Cd-induced autophagy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	beclin 1, autophagy related	Mus musculus	120-128
33860870-9	2021	The level of IFN-gamma was increased in triciribine, LY294002, and torin2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	interferon gamma	Mus musculus	13-22
33860870-10	2021	Metformin, metformin and ketamine, triciribine, LY294002, and torin2 reduced Akt and PI3K expression, peribronchial and perivascular inflammation, and increased expression of Foxp3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	thymoma viral proto-oncogene 1	Mus musculus	77-80
33860870-10	2021	Metformin, metformin and ketamine, triciribine, LY294002, and torin2 reduced Akt and PI3K expression, peribronchial and perivascular inflammation, and increased expression of Foxp3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	forkhead box P3	Mus musculus	175-180
33856720-5	2021	Furthermore, AKT inhibitor LY294002 blocked the expression of p-AKT, c-Myc, HK2, PKM2, and pro-cas3 in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	13-16
33856720-5	2021	Furthermore, AKT inhibitor LY294002 blocked the expression of p-AKT, c-Myc, HK2, PKM2, and pro-cas3 in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	64-67
33856720-5	2021	Furthermore, AKT inhibitor LY294002 blocked the expression of p-AKT, c-Myc, HK2, PKM2, and pro-cas3 in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-74
33856720-5	2021	Furthermore, AKT inhibitor LY294002 blocked the expression of p-AKT, c-Myc, HK2, PKM2, and pro-cas3 in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	hexokinase 2	Homo sapiens	76-79
33856720-5	2021	Furthermore, AKT inhibitor LY294002 blocked the expression of p-AKT, c-Myc, HK2, PKM2, and pro-cas3 in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	pyruvate kinase M1/2	Homo sapiens	81-85
33856720-5	2021	Furthermore, AKT inhibitor LY294002 blocked the expression of p-AKT, c-Myc, HK2, PKM2, and pro-cas3 in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	embryonal Fyn-associated substrate	Homo sapiens	95-99
33710186-9	2021	Western blot analysis results also implied that active-constituent pretreatment reversed the diminished expression of the PI3K/Akt/mTOR pathway mediated by oxygen glucose deprivation/reperfusion (OGD/R); further experimental evidence showed that the protective role was limited in the PI3K inhibitor (LY294002) treatment group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	301-309	thymoma viral proto-oncogene 1	Mus musculus	127-130
33646053-5	2021	rhWISP1 inhibited OA chondrocyte senescence and apoptosis in vitro, which was reversed by the alphavbeta3 antibody and PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	AKT serine/threonine kinase 1	Rattus norvegicus	124-127
33898501-10	2021	Correspondingly, the protective effect of CM was dramatically blocked after interference with phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002, indicating that the protective effect of CM on cell oxidative damage was attributed to PI3K/Akt-mediated Nrf2/HO-1 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	AKT serine/threonine kinase 1	Homo sapiens	131-134
33898501-10	2021	Correspondingly, the protective effect of CM was dramatically blocked after interference with phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002, indicating that the protective effect of CM on cell oxidative damage was attributed to PI3K/Akt-mediated Nrf2/HO-1 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	AKT serine/threonine kinase 1	Homo sapiens	247-250
33898501-10	2021	Correspondingly, the protective effect of CM was dramatically blocked after interference with phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002, indicating that the protective effect of CM on cell oxidative damage was attributed to PI3K/Akt-mediated Nrf2/HO-1 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	NFE2 like bZIP transcription factor 2	Homo sapiens	260-264
33898501-10	2021	Correspondingly, the protective effect of CM was dramatically blocked after interference with phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002, indicating that the protective effect of CM on cell oxidative damage was attributed to PI3K/Akt-mediated Nrf2/HO-1 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	heme oxygenase 1	Homo sapiens	265-269
33734020-8	2021	Finally, we found that LY294002, a specific inhibitor of the PI3K/Akt pathway, inhibited the protective effect of MR against H2O2-induced OLN-93 cell injury in the MTT and TUNEL assays.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Rattus norvegicus	66-69
33734020-9	2021	LY294002 also inhibited the expression of SOD and Bcl-2, and increased the expression of iNOS and c-caspase-3 induced by MR treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2, apoptosis regulator	Rattus norvegicus	50-55
33734020-9	2021	LY294002 also inhibited the expression of SOD and Bcl-2, and increased the expression of iNOS and c-caspase-3 induced by MR treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 2	Rattus norvegicus	89-93
33734020-9	2021	LY294002 also inhibited the expression of SOD and Bcl-2, and increased the expression of iNOS and c-caspase-3 induced by MR treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Rattus norvegicus	100-109
33732339-11	2021	Furthermore, PI3K inhibitor LY294002 inhibited activation of the PI3K/AKT signaling pathway and decreased the proliferation and migration of HaCaT keratinocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	70-73
33611830-8	2021	The protective effects mediated by MARCH5 overexpression on ECs could be inhibited by eNOS inhibitor L-NAME and Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	AKT serine/threonine kinase 1	Homo sapiens	112-115
33030052-6	2021	LY 294002 and glibenclamide reversed lipid emulsion-mediated inhibition of cleaved caspase-3 and -8 expression induced by amlodipine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	caspase 3	Rattus norvegicus	83-99
33732347-6	2021	A total of 10 microM PI3K/AKT inhibitor LY294002 was supplemented to the cells during the experiments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Rattus norvegicus	26-29
33732347-13	2021	Mechanistic studies concluded that the apoptosis-inhibitory contributions and cardio-favorable effects of PIP were caused partly by the activation of the PI3K/AKT signaling pathway, which was verified by LY294002 administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	204-212	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
33721206-11	2021	After 21 d of induction, the Western blot results showed that the protein expression levels of NSE, MAP-2, and TH in the 10 mumol/L, 3 mumol/L, and 1 mumol/L ICS II groups were significantly higher than those in the LY294002+3muM ICS II and control groups.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	216-224	enolase 2	Homo sapiens	95-98
33721206-11	2021	After 21 d of induction, the Western blot results showed that the protein expression levels of NSE, MAP-2, and TH in the 10 mumol/L, 3 mumol/L, and 1 mumol/L ICS II groups were significantly higher than those in the LY294002+3muM ICS II and control groups.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	216-224	tyrosine hydroxylase	Homo sapiens	111-113
33724692-8	2021	Also, T3 increased the expression of IGF-1, and PI3K/Akt signalling in cardiomyocytes under H/R-induced injury, and that the protective effect of T3 against H/R-induced injury was blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	insulin-like growth factor 1	Mus musculus	37-42
33508440-9	2021	However, wortmannin and LY294002, inhibitors of the PI3K/Akt pathway, abolished the up- and down-regulation of E- and N-cadherin expression respectively, and inhibition of migration induced by DHEA in MDA-MB-231 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	57-60
33537812-11	2021	It was found that the PI3K/Akt signaling pathway was activated in high glucose-stimulated HKC cells, and inhibition of PI3K/Akt pathway using LY294002 increased FBXW7 expression and decreased SREBP-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	thymoma viral proto-oncogene 1	Mus musculus	124-127
33537812-11	2021	It was found that the PI3K/Akt signaling pathway was activated in high glucose-stimulated HKC cells, and inhibition of PI3K/Akt pathway using LY294002 increased FBXW7 expression and decreased SREBP-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	F-box and WD-40 domain protein 7	Mus musculus	161-166
33537812-11	2021	It was found that the PI3K/Akt signaling pathway was activated in high glucose-stimulated HKC cells, and inhibition of PI3K/Akt pathway using LY294002 increased FBXW7 expression and decreased SREBP-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	sterol regulatory element binding transcription factor 1	Mus musculus	192-199
33481205-6	2021	Furthermore, we found that methyllycaconitine, the antagonist of alpha7 nicotinic acetylcholine receptor (alpha7nAChR), and LY294002, the inhibitor of phosphoinositide 3-kinase (PI3K), were able to block the cognitive effects of S-ORC after MCAO/R in rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	151-176
33537834-8	2021	The PI3K inhibitor, LY294002, blocked BMP2-induced osteoblastogenesis, suggesting that the PI3K/AKT pathway is critically required for BMP2 to initiate osteoblastogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	bone morphogenetic protein 2	Mus musculus	38-42
33537834-8	2021	The PI3K inhibitor, LY294002, blocked BMP2-induced osteoblastogenesis, suggesting that the PI3K/AKT pathway is critically required for BMP2 to initiate osteoblastogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	thymoma viral proto-oncogene 1	Mus musculus	96-99
33537834-8	2021	The PI3K inhibitor, LY294002, blocked BMP2-induced osteoblastogenesis, suggesting that the PI3K/AKT pathway is critically required for BMP2 to initiate osteoblastogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	bone morphogenetic protein 2	Mus musculus	135-139
33508440-9	2021	However, wortmannin and LY294002, inhibitors of the PI3K/Akt pathway, abolished the up- and down-regulation of E- and N-cadherin expression respectively, and inhibition of migration induced by DHEA in MDA-MB-231 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	cadherin 2	Homo sapiens	118-128
33732383-7	2021	Ly294002 provoked a 9.6- and 5.9-fold increase in the amounts of TRPC5 mRNA in MNNG-HOS and U-2 OS cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transient receptor potential cation channel subfamily C member 5	Homo sapiens	65-70
33732383-8	2021	Additionally, Ly294002 increased TRPC6 mRNA levels; however, it had no effect on TRPCs 1, 3 and 4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	transient receptor potential cation channel subfamily C member 6	Homo sapiens	33-38
33645479-11	2021	Furthermore, fisetin activated the phosphoinositide-3-kinase/protein kinase B (PI3K-AKT) signaling pathway, and blocking this pathway by the inhibitor LY-294002 could impair fisetin"s functions on proliferation, differentiation and OPG/RANKL expression ratio in the MC3T3-E1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-160	thymoma viral proto-oncogene 1	Mus musculus	84-87
33516933-12	2021	The expression of NCX3 protein was reduced in the SK-N-SH cells treated with Akt phosphorylation inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	solute carrier family 8 member A3	Homo sapiens	18-22
33516933-12	2021	The expression of NCX3 protein was reduced in the SK-N-SH cells treated with Akt phosphorylation inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Homo sapiens	77-80
33731670-7	2021	More importantly, autophagic inhibition by the suppressors 3-methyladenine (3-MA) and LY294002 significantly potentiated cytotoxicity and apoptosis in HER2-positive GC cells in vitro, while the combined use of LY294002 and T-DM1 elicited potent anti-GC efficacy in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	151-155
33470770-8	2021	When the PI3K inhibitor LY294002 was added, neuronal viability and the expression of pAkt and GLT-1 decreased, and extracellular glutamate concentration increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	solute carrier family 1 member 2	Rattus norvegicus	94-99
33609179-9	2021	The Akt signaling inhibitors wortmannin and LY294002 could block the cardioprotective effect of apelin, which could be relieved by ERS inhibitor 4-phenyl butyric acid (4-PBA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	APLN	Oryctolagus cuniculus	96-102
33786723-8	2021	LY294002 abrogated the beneficial effects of targeting c-Abl and exacerbated neuronal apoptosis after SAH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	55-60
33772736-9	2022	In addition, LY294002 pretreatment reduced the activity of SOD, GSH-Px, and CAT but elevated MDA levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	glutathione peroxidase 1	Rattus norvegicus	64-70
33772736-9	2022	In addition, LY294002 pretreatment reduced the activity of SOD, GSH-Px, and CAT but elevated MDA levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	catalase	Rattus norvegicus	76-79
33772736-10	2022	Meanwhile, LY294002 pretreatment also increased cell apoptosis given the upregulated Bax and Caspase-3 mRNAs and decreased Bcl-2 mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	BCL2 associated X, apoptosis regulator	Rattus norvegicus	85-88
33772736-10	2022	Meanwhile, LY294002 pretreatment also increased cell apoptosis given the upregulated Bax and Caspase-3 mRNAs and decreased Bcl-2 mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	caspase 3	Rattus norvegicus	93-102
33772736-10	2022	Meanwhile, LY294002 pretreatment also increased cell apoptosis given the upregulated Bax and Caspase-3 mRNAs and decreased Bcl-2 mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	BCL2, apoptosis regulator	Rattus norvegicus	123-128
33188898-11	2021	Besides, it can be revealed from the western blot assay that LY294002, as a selective Phosphatidylinositol 3-Kinase (PI3K) inhibitor, effectively inhibited the Akt phosphorylation caused by Rhy, which suggested that Rhy showed its protective property through the activated the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	86-115
33188898-11	2021	Besides, it can be revealed from the western blot assay that LY294002, as a selective Phosphatidylinositol 3-Kinase (PI3K) inhibitor, effectively inhibited the Akt phosphorylation caused by Rhy, which suggested that Rhy showed its protective property through the activated the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Rattus norvegicus	160-163
33188898-11	2021	Besides, it can be revealed from the western blot assay that LY294002, as a selective Phosphatidylinositol 3-Kinase (PI3K) inhibitor, effectively inhibited the Akt phosphorylation caused by Rhy, which suggested that Rhy showed its protective property through the activated the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Rattus norvegicus	282-285
33188898-12	2021	Moreover, the Rhy-induced decreases of Bax and caspase-3 as the proapoptotic markers and the increase of Bcl-2 as the antiapoptotic marker, were blocked by LY294002 in the MPP+-treated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	BCL2 associated X, apoptosis regulator	Rattus norvegicus	39-42
33188898-12	2021	Moreover, the Rhy-induced decreases of Bax and caspase-3 as the proapoptotic markers and the increase of Bcl-2 as the antiapoptotic marker, were blocked by LY294002 in the MPP+-treated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	caspase 3	Rattus norvegicus	47-56
33188898-12	2021	Moreover, the Rhy-induced decreases of Bax and caspase-3 as the proapoptotic markers and the increase of Bcl-2 as the antiapoptotic marker, were blocked by LY294002 in the MPP+-treated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	BCL2, apoptosis regulator	Rattus norvegicus	105-110
33754417-6	2021	The cells were subjected to various assays and treated with the selective Akt inhibitor LY294002 or co-transfected with galectin-3-binding protein (LGALS3BP) siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Homo sapiens	74-77
33742315-9	2021	LY294002 also prominently decreased phosphorylation of AKT in vivo and vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	55-58
33742315-10	2021	By RT-PCR and Western blot analysis, LY294002 blocked the PI3K/AKT-induced loss of E-cadherin expression and de novo increase of the expression of alpha-SMA in a time- and dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Rattus norvegicus	63-66
33742315-10	2021	By RT-PCR and Western blot analysis, LY294002 blocked the PI3K/AKT-induced loss of E-cadherin expression and de novo increase of the expression of alpha-SMA in a time- and dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	cadherin 1	Mus musculus	83-93
33742315-10	2021	By RT-PCR and Western blot analysis, LY294002 blocked the PI3K/AKT-induced loss of E-cadherin expression and de novo increase of the expression of alpha-SMA in a time- and dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	actin alpha 2, smooth muscle, aorta	Mus musculus	147-156
33485844-5	2021	Furthermore, PCGF3 affected both the proliferation and migration of lung cancer cells by regulating the PI3K/AKT pathway, as verified by inhibiting this pathway using LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	polycomb group ring finger 3	Homo sapiens	13-18
33485844-5	2021	Furthermore, PCGF3 affected both the proliferation and migration of lung cancer cells by regulating the PI3K/AKT pathway, as verified by inhibiting this pathway using LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	AKT serine/threonine kinase 1	Homo sapiens	109-112
33715582-9	2021	Moreover, S1PR1-induced addition of cell growth was clearly alleviated in LY294002 or S3I-201 treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	sphingosine-1-phosphate receptor 1	Homo sapiens	10-15
32767595-15	2021	However, treatment with LY294002 significantly reversed that IPC-Exo-induced increase in p-PI3K and p-AKT levels, improvement of haemodynamics, and decrease of inflammatory factor production and apoptosis in the I/R + IPC-Exo group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
33645479-11	2021	Furthermore, fisetin activated the phosphoinositide-3-kinase/protein kinase B (PI3K-AKT) signaling pathway, and blocking this pathway by the inhibitor LY-294002 could impair fisetin"s functions on proliferation, differentiation and OPG/RANKL expression ratio in the MC3T3-E1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-160	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	232-235
33645479-11	2021	Furthermore, fisetin activated the phosphoinositide-3-kinase/protein kinase B (PI3K-AKT) signaling pathway, and blocking this pathway by the inhibitor LY-294002 could impair fisetin"s functions on proliferation, differentiation and OPG/RANKL expression ratio in the MC3T3-E1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-160	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	236-241
33602886-9	2021	Furthermore, hypoxiaactivated extracellular signal-regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) were completely abolished by Src inhibitor 1 (1.0 microM), and hypoxia-increased GATA4 was inhibited by the ERK1/2 and Akt antagonists PD98059 (10.0 microM) and LY294002 (10.0 microM), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	269-277	mitogen activated protein kinase 3	Rattus norvegicus	30-71
33412213-9	2021	Finally, the cell proliferation, migration and invasion ability were detected when A2780 and SKOV3 cells with CNOT7 overexpression were treated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	CCR4-NOT transcription complex subunit 7	Homo sapiens	110-115
33412213-16	2021	It is worth noting that the effect of CNOT7 overexpression in A2780 and SKOV3 cells could be partially or completely eliminated by treatment with AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	CCR4-NOT transcription complex subunit 7	Homo sapiens	38-43
33412213-16	2021	It is worth noting that the effect of CNOT7 overexpression in A2780 and SKOV3 cells could be partially or completely eliminated by treatment with AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	AKT serine/threonine kinase 1	Homo sapiens	146-149
33602886-9	2021	Furthermore, hypoxiaactivated extracellular signal-regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) were completely abolished by Src inhibitor 1 (1.0 microM), and hypoxia-increased GATA4 was inhibited by the ERK1/2 and Akt antagonists PD98059 (10.0 microM) and LY294002 (10.0 microM), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	269-277	mitogen activated protein kinase 3	Rattus norvegicus	73-79
33602886-9	2021	Furthermore, hypoxiaactivated extracellular signal-regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) were completely abolished by Src inhibitor 1 (1.0 microM), and hypoxia-increased GATA4 was inhibited by the ERK1/2 and Akt antagonists PD98059 (10.0 microM) and LY294002 (10.0 microM), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	269-277	AKT serine/threonine kinase 1	Rattus norvegicus	103-106
33602886-9	2021	Furthermore, hypoxiaactivated extracellular signal-regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) were completely abolished by Src inhibitor 1 (1.0 microM), and hypoxia-increased GATA4 was inhibited by the ERK1/2 and Akt antagonists PD98059 (10.0 microM) and LY294002 (10.0 microM), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	269-277	GATA binding protein 4	Rattus norvegicus	189-194
33629579-10	2021	On the contrary, protein kinase B (AKT) inhibitor LY294002 counteracted the protective effect of DEX on heart, suggesting that GPR30 enhanced the protective effect of DEX on ischemia-reperfusion induced heart injury by regulating AKT related pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Rattus norvegicus	35-38
33258087-9	2021	HMC-EVs-carried miR-24 could target AQP4 to activate the P38 MAPK/ERK1/2/P13K/AKT pathway, and thus promoted the proliferation and migration of SH-SY5Y cells after H/R injury, which were reversed by LY294002 and PD98095.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-207	aquaporin 4	Homo sapiens	36-40
33258087-9	2021	HMC-EVs-carried miR-24 could target AQP4 to activate the P38 MAPK/ERK1/2/P13K/AKT pathway, and thus promoted the proliferation and migration of SH-SY5Y cells after H/R injury, which were reversed by LY294002 and PD98095.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-207	mitogen-activated protein kinase 3	Homo sapiens	66-72
33258087-9	2021	HMC-EVs-carried miR-24 could target AQP4 to activate the P38 MAPK/ERK1/2/P13K/AKT pathway, and thus promoted the proliferation and migration of SH-SY5Y cells after H/R injury, which were reversed by LY294002 and PD98095.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-207	AKT serine/threonine kinase 1	Homo sapiens	78-81
33716739-12	2021	And experimental studies demonstrated that pretreatment of HJF increased the phosphorylation of AKT and mTOR, and the effects of HJF on autophagy would be offset by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
33629579-10	2021	On the contrary, protein kinase B (AKT) inhibitor LY294002 counteracted the protective effect of DEX on heart, suggesting that GPR30 enhanced the protective effect of DEX on ischemia-reperfusion induced heart injury by regulating AKT related pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	G protein-coupled estrogen receptor 1	Rattus norvegicus	127-132
33629579-10	2021	On the contrary, protein kinase B (AKT) inhibitor LY294002 counteracted the protective effect of DEX on heart, suggesting that GPR30 enhanced the protective effect of DEX on ischemia-reperfusion induced heart injury by regulating AKT related pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Rattus norvegicus	230-233
33598775-10	2021	Interestingly, the effect of FCX on NRF2 nuclear translocation was noticeably diminished by LY294002, an inhibitor of PI3K, but not by inhibitors of mitogen-activated protein kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
33708630-8	2021	These effects were significantly attenuated when PI3K or mTOR were inhibited by LY294002 or rapamycin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	mechanistic target of rapamycin kinase	Mus musculus	57-61
33658766-8	2021	Moreover, rats in the CME + BE + LY group were intraperitoneally injected with the phosphoinositide 3-kinase (PI3K) specific inhibitor, LY294002 (10 mg/kg) 30 minutes before CME modeling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	83-108
33632134-5	2021	Mice were treated with MaR1 (5-20 ng/mouse), Boc2 (Lipoxin A4 receptor antagonist), LY294002 (Akt inhibitor) or corresponding controls just prior to liver I/R or at the beginning of reperfusion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	thymoma viral proto-oncogene 1	Mus musculus	94-97
33681258-12	2021	Treatment with LY294002 significantly increased the apoptosis of NPCs and reduced the levels of their downstream substrates (p-AKT, p-mTOR, and p-GSK3beta).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	127-130
33681258-12	2021	Treatment with LY294002 significantly increased the apoptosis of NPCs and reduced the levels of their downstream substrates (p-AKT, p-mTOR, and p-GSK3beta).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mechanistic target of rapamycin kinase	Homo sapiens	134-138
33681258-12	2021	Treatment with LY294002 significantly increased the apoptosis of NPCs and reduced the levels of their downstream substrates (p-AKT, p-mTOR, and p-GSK3beta).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	glycogen synthase kinase 3 alpha	Homo sapiens	146-154
33621956-8	2021	And miR-483-5p inhibitor, SATB2-overexpressed lentiviruses (Lv-SATB2) or LY294002 (PI3K/AKT inhibitor) significantly reversed the above results.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Homo sapiens	88-91
33621956-9	2021	Similarly, PI3K/AKT signaling was activated by miR-483-5p mimic, and was inhibited in miR-483-5p inhibitor, Lv-SATB2 or LY294002 treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	16-19
33621956-9	2021	Similarly, PI3K/AKT signaling was activated by miR-483-5p mimic, and was inhibited in miR-483-5p inhibitor, Lv-SATB2 or LY294002 treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	microRNA 483	Mus musculus	47-54
33664668-5	2021	Ang II-induced autophagic increases were potentiated by inhibition of PI3KC1 with LY294002, but were impaired by inhibition of PI3KC3 with 3-methyladenine (3-MA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	angiotensinogen	Rattus norvegicus	0-6
33432947-11	2021	The PI3K inhibitor LY294002 dramatically decreased the p-Akt expression and activated FoxO1 by dephosphorylation, thus diminishing the inhibitory effects of Rsv on dapagliflozin-induced PEPCK and G6Pase expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	thymoma viral proto-oncogene 1	Mus musculus	57-60
33432947-11	2021	The PI3K inhibitor LY294002 dramatically decreased the p-Akt expression and activated FoxO1 by dephosphorylation, thus diminishing the inhibitory effects of Rsv on dapagliflozin-induced PEPCK and G6Pase expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	forkhead box O1	Mus musculus	86-91
33432947-11	2021	The PI3K inhibitor LY294002 dramatically decreased the p-Akt expression and activated FoxO1 by dephosphorylation, thus diminishing the inhibitory effects of Rsv on dapagliflozin-induced PEPCK and G6Pase expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	186-191
33432947-11	2021	The PI3K inhibitor LY294002 dramatically decreased the p-Akt expression and activated FoxO1 by dephosphorylation, thus diminishing the inhibitory effects of Rsv on dapagliflozin-induced PEPCK and G6Pase expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	glucose-6-phosphatase, catalytic	Mus musculus	196-202
33603340-9	2021	Finally, AKT blockage by 10 muM LY294002 or Nrf2 inhibition by10 mu M ML385 were utilized to prove the involvement of AKT and Nrf2/HO-1 pathway in AKI during sepsis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	thymoma viral proto-oncogene 1	Mus musculus	9-12
33535306-13	2021	The expression levels of p-Akt, p-GSK3beta and beta-catenin were decreased when the PI3K/Akt pathway was blocked using the PI3K inhibitor LY294002 (P<0.05), and the expression levels of N-Cadherin, vimentin and Snail were also significantly decreased (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	AKT serine/threonine kinase 1	Homo sapiens	27-30
33535306-13	2021	The expression levels of p-Akt, p-GSK3beta and beta-catenin were decreased when the PI3K/Akt pathway was blocked using the PI3K inhibitor LY294002 (P<0.05), and the expression levels of N-Cadherin, vimentin and Snail were also significantly decreased (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	glycogen synthase kinase 3 alpha	Homo sapiens	34-42
33535306-13	2021	The expression levels of p-Akt, p-GSK3beta and beta-catenin were decreased when the PI3K/Akt pathway was blocked using the PI3K inhibitor LY294002 (P<0.05), and the expression levels of N-Cadherin, vimentin and Snail were also significantly decreased (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	catenin beta 1	Homo sapiens	47-59
33535306-13	2021	The expression levels of p-Akt, p-GSK3beta and beta-catenin were decreased when the PI3K/Akt pathway was blocked using the PI3K inhibitor LY294002 (P<0.05), and the expression levels of N-Cadherin, vimentin and Snail were also significantly decreased (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	AKT serine/threonine kinase 1	Homo sapiens	89-92
33535178-11	2021	Pre-incubation with IMD17-47 (IMD receptors blocking peptide) and the phosphatidylinositol 3-kinase/protein kinase b (PI3K/Akt) inhibitor LY294002 reversed ADAM10 level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	protein tyrosine kinase 2 beta	Homo sapiens	100-116
33534374-10	2021	Besides, TWSG1 overexpression enhanced proliferation in glioma cells, and the capacity of proliferation was partly abolished by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	twisted gastrulation BMP signaling modulator 1	Mus musculus	9-14
33528684-10	2021	Since 7,8-DHF increased Akt phosphorylation, and LY294002 (an antagonist of PI3K upstream of Akt) dramatically inhibited both 7,8-DHF-augmented M3 expression and 7,8-DHF-enhanced/CCh-stimulated contractions, we assumed that 7,8-DHF/TrkB/Akt was associated with the modulation of M3 expression in the colonic strips.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
33528684-10	2021	Since 7,8-DHF increased Akt phosphorylation, and LY294002 (an antagonist of PI3K upstream of Akt) dramatically inhibited both 7,8-DHF-augmented M3 expression and 7,8-DHF-enhanced/CCh-stimulated contractions, we assumed that 7,8-DHF/TrkB/Akt was associated with the modulation of M3 expression in the colonic strips.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	232-236
33528684-10	2021	Since 7,8-DHF increased Akt phosphorylation, and LY294002 (an antagonist of PI3K upstream of Akt) dramatically inhibited both 7,8-DHF-augmented M3 expression and 7,8-DHF-enhanced/CCh-stimulated contractions, we assumed that 7,8-DHF/TrkB/Akt was associated with the modulation of M3 expression in the colonic strips.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
33614622-10	2020	Meanwhile, the BMP9-induced Wnt10b is also reduced by a PI3K-specific inhibitor (Ly294002) or rapamycin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	growth differentiation factor 2	Homo sapiens	15-19
33614622-10	2020	Meanwhile, the BMP9-induced Wnt10b is also reduced by a PI3K-specific inhibitor (Ly294002) or rapamycin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	Wnt family member 10B	Homo sapiens	28-34
33535178-11	2021	Pre-incubation with IMD17-47 (IMD receptors blocking peptide) and the phosphatidylinositol 3-kinase/protein kinase b (PI3K/Akt) inhibitor LY294002 reversed ADAM10 level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	AKT serine/threonine kinase 1	Homo sapiens	123-126
33535178-11	2021	Pre-incubation with IMD17-47 (IMD receptors blocking peptide) and the phosphatidylinositol 3-kinase/protein kinase b (PI3K/Akt) inhibitor LY294002 reversed ADAM10 level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	ADAM metallopeptidase domain 10	Homo sapiens	156-162
33226571-7	2021	Furthermore, blockade of PI3K/AKT signal with LY294002 significantly reduced melatonin-induced apoptosis inhibition in H2O2-treated HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	30-33
33446037-9	2021	Moreover, LY294002, an inhibitor of the PI3K/AKT pathway, restored the chemosensitivity of CRC cells expressing high levels of NPM1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	45-48
33446037-9	2021	Moreover, LY294002, an inhibitor of the PI3K/AKT pathway, restored the chemosensitivity of CRC cells expressing high levels of NPM1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	nucleophosmin 1	Homo sapiens	127-131
33456508-7	2021	Further study demonstrated that a pharmacological inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt pathway, LY294002, inhibited the expression of NF-kappaB p65 in the nuclear fraction and decreased the production of inflammatory cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	67-92
33456508-7	2021	Further study demonstrated that a pharmacological inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt pathway, LY294002, inhibited the expression of NF-kappaB p65 in the nuclear fraction and decreased the production of inflammatory cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	thymoma viral proto-oncogene 1	Mus musculus	100-103
33388654-6	2021	Compounds 8, 9 and 11 showed good inhibitory activity against PI3Kalpha with IC50 values 4.1, 7.8, and 20.5 microM, respectively in comparison to 6.18 microM for the reference compound LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	62-71
33352197-4	2021	To this end, we used bisulfite sequencing polymerase chain reaction and Western blot analysis, to study the effects of 5-aza-2"-deoxycytidine and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, which inhibit methyltransferase and PI3K respectively, on DNA methylation and expression of downstream effectors of PI3K related to corneal NV, including TSC1 and mTOR genes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-194	TSC complex subunit 1	Mus musculus	350-354
33352197-4	2021	To this end, we used bisulfite sequencing polymerase chain reaction and Western blot analysis, to study the effects of 5-aza-2"-deoxycytidine and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, which inhibit methyltransferase and PI3K respectively, on DNA methylation and expression of downstream effectors of PI3K related to corneal NV, including TSC1 and mTOR genes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-194	mechanistic target of rapamycin kinase	Mus musculus	359-363
33068248-7	2021	Treatment of t(8;21) AML cells with the autophagy inhibitors chloroquine (CQ) or LY294002 in combination with the CDK4/6 inhibitor abemaciclib significantly increased the percentage of apoptotic (Annexin V positive) cells, whereas CQ or LY294002 single treatment had no significant effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	annexin A5	Homo sapiens	196-205
33068248-7	2021	Treatment of t(8;21) AML cells with the autophagy inhibitors chloroquine (CQ) or LY294002 in combination with the CDK4/6 inhibitor abemaciclib significantly increased the percentage of apoptotic (Annexin V positive) cells, whereas CQ or LY294002 single treatment had no significant effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	237-245	cyclin dependent kinase 4	Homo sapiens	114-120
33227289-8	2021	Additionally, we found that coptisine suppressed the phosphorylation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR), and this effect was notably enhanced by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	mechanistic target of rapamycin kinase	Homo sapiens	115-144
33468992-7	2021	Pharmacologic inhibition of Akt using LY294002 and Akt1/2 knockdown using shRNA in sarcoma CSCs decreased Nanog expression and spheroid formation and reversed chemotherapy resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	28-31
33222058-7	2021	It was discovered that HIOC could increase the nuclear translocation of Nrf2, and that this induction can be reversed by the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	NFE2 like bZIP transcription factor 2	Rattus norvegicus	72-76
33222058-7	2021	It was discovered that HIOC could increase the nuclear translocation of Nrf2, and that this induction can be reversed by the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	AKT serine/threonine kinase 1	Rattus norvegicus	130-133
33678633-12	2021	Compared to the MFN-M group, cell apoptosis and the protein level of Bax in the MFN+LY294002 group were significantly increased; the Bcl-2 protein expression was significantly decreased (all P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	BCL2-associated X protein	Mus musculus	69-72
33613982-5	2021	In addition, pro-inflammatory cytokine expressions of TNF-alpha and IL-6 induced by the binary mixture of Phe and Flu were all alleviated by co-treatment with PI3K/AKT and NF-kappaB specific inhibitors (LY294002 and BAY11-7082).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	tumor necrosis factor	Homo sapiens	54-63
33613982-5	2021	In addition, pro-inflammatory cytokine expressions of TNF-alpha and IL-6 induced by the binary mixture of Phe and Flu were all alleviated by co-treatment with PI3K/AKT and NF-kappaB specific inhibitors (LY294002 and BAY11-7082).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	interleukin 6	Homo sapiens	68-72
33613982-5	2021	In addition, pro-inflammatory cytokine expressions of TNF-alpha and IL-6 induced by the binary mixture of Phe and Flu were all alleviated by co-treatment with PI3K/AKT and NF-kappaB specific inhibitors (LY294002 and BAY11-7082).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	AKT serine/threonine kinase 1	Homo sapiens	164-167
33227289-8	2021	Additionally, we found that coptisine suppressed the phosphorylation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR), and this effect was notably enhanced by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	AKT serine/threonine kinase 1	Homo sapiens	151-154
33227289-8	2021	Additionally, we found that coptisine suppressed the phosphorylation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR), and this effect was notably enhanced by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	mechanistic target of rapamycin kinase	Homo sapiens	155-159
33217443-8	2021	Additionally, the addition of Akt inhibitor LY294002 reversed the effects of RECQL5 overexpression on cell migration, invasion and EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	30-33
33217443-8	2021	Additionally, the addition of Akt inhibitor LY294002 reversed the effects of RECQL5 overexpression on cell migration, invasion and EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	RecQ like helicase 5	Homo sapiens	77-83
33249098-11	2021	Besides, PI3K/AKT signaling suppression with LY294002 abolished the neuroprotective functions induced by silencing PAQR3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
33438566-14	2021	We found anlotinib and LY294002 overcame the drug resistance of HCT-8/5-FU cells by reducing the expression of PI3K/p-AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	118-121
33249098-11	2021	Besides, PI3K/AKT signaling suppression with LY294002 abolished the neuroprotective functions induced by silencing PAQR3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	progestin and adipoQ receptor family member 3	Rattus norvegicus	115-120
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	AKT serine/threonine kinase 1	Homo sapiens	154-157
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	AKT serine/threonine kinase 1	Homo sapiens	270-273
33505496-9	2021	Both hypoxia and IL-8 may promote angiogenesis which was suppressed by JR. Western blot showed that IL-8 upregulated the expression of phosphorylation of AKT, ERK, NF-kappaB, and VEGFR, which were inhibited by JR. On the other hand, effects of IL-8 on the increase of p-AKT and p-ERK were also blocked by LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	mitogen-activated protein kinase 1	Homo sapiens	280-283
33438566-10	2021	LY294002 was used to verify whether anlotinib overcomes the drug-resistance of CRC cells by inactivating the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	114-117
33437022-8	2021	In vitro, blocking Akt and p-FoxO3a activation with the PI3K inhibitor LY294002 effectively suppressed the protective effects of several active monomers (including quercetin, macelignan,methyleugenol and Santol) of SWTX against H2O2-induced injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
33437022-8	2021	In vitro, blocking Akt and p-FoxO3a activation with the PI3K inhibitor LY294002 effectively suppressed the protective effects of several active monomers (including quercetin, macelignan,methyleugenol and Santol) of SWTX against H2O2-induced injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	forkhead box O3	Rattus norvegicus	29-35
33241954-5	2021	In addition, CXCL6-induced HBMEC permeability and inhibition of HBMEC proliferation were counteracted by Sirt3 overexpression, and the AKT inhibitor LY294002 counteracted the effect of CXCL6 recombinant proteins on Sirt3, p-AKT, and p-FOXO3a expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	C-X-C motif chemokine ligand 6	Homo sapiens	13-18
33414476-5	2021	Furthermore, HDAC5 expression was regulated by PI3K/Akt signaling pathway and inhibition of PI3K/Akt pathway by LY294002 treatment or Akt phosphorylation mutation reduced HDAC5 and TGF-beta1 expression in vitro high glucose-cultured HK2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	thymoma viral proto-oncogene 1	Mus musculus	97-100
33414476-5	2021	Furthermore, HDAC5 expression was regulated by PI3K/Akt signaling pathway and inhibition of PI3K/Akt pathway by LY294002 treatment or Akt phosphorylation mutation reduced HDAC5 and TGF-beta1 expression in vitro high glucose-cultured HK2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	thymoma viral proto-oncogene 1	Mus musculus	97-100
33414476-5	2021	Furthermore, HDAC5 expression was regulated by PI3K/Akt signaling pathway and inhibition of PI3K/Akt pathway by LY294002 treatment or Akt phosphorylation mutation reduced HDAC5 and TGF-beta1 expression in vitro high glucose-cultured HK2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	histone deacetylase 5	Mus musculus	171-176
33414476-5	2021	Furthermore, HDAC5 expression was regulated by PI3K/Akt signaling pathway and inhibition of PI3K/Akt pathway by LY294002 treatment or Akt phosphorylation mutation reduced HDAC5 and TGF-beta1 expression in vitro high glucose-cultured HK2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	transforming growth factor, beta 1	Mus musculus	181-190
33486250-9	2021	Curcumin-mediated attenuation of caspase-3 activation was reversed by Akt inhibitor LY294002 (LY).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	caspase 3	Homo sapiens	33-42
33486250-9	2021	Curcumin-mediated attenuation of caspase-3 activation was reversed by Akt inhibitor LY294002 (LY).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Homo sapiens	70-73
33486250-9	2021	Curcumin-mediated attenuation of caspase-3 activation was reversed by Akt inhibitor LY294002 (LY).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-86	caspase 3	Homo sapiens	33-42
33486250-9	2021	Curcumin-mediated attenuation of caspase-3 activation was reversed by Akt inhibitor LY294002 (LY).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-86	AKT serine/threonine kinase 1	Homo sapiens	70-73
33409876-8	2021	Culture of the ovarian tissue with LY294002 inhibited the activation of primordial follicles and reduced p-Akt immunostaining in both alpha-MEM+ and 50 ng/ml GDF-9 treatments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	RAC-alpha serine/threonine-protein kinase	Ovis aries	107-110
33409876-8	2021	Culture of the ovarian tissue with LY294002 inhibited the activation of primordial follicles and reduced p-Akt immunostaining in both alpha-MEM+ and 50 ng/ml GDF-9 treatments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	growth/differentiation factor 9	Ovis aries	158-163
33409876-9	2021	In addition, after culture with LY294002, the percentage of oocytes with nuclear p-FOXO3 was higher in 50 ng/ml GDF-9 than in the control medium (alpha-MEM+).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	forkhead box protein O3	Ovis aries	83-88
33409876-9	2021	In addition, after culture with LY294002, the percentage of oocytes with nuclear p-FOXO3 was higher in 50 ng/ml GDF-9 than in the control medium (alpha-MEM+).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	growth/differentiation factor 9	Ovis aries	112-117
33241954-5	2021	In addition, CXCL6-induced HBMEC permeability and inhibition of HBMEC proliferation were counteracted by Sirt3 overexpression, and the AKT inhibitor LY294002 counteracted the effect of CXCL6 recombinant proteins on Sirt3, p-AKT, and p-FOXO3a expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	AKT serine/threonine kinase 1	Homo sapiens	135-138
33241954-5	2021	In addition, CXCL6-induced HBMEC permeability and inhibition of HBMEC proliferation were counteracted by Sirt3 overexpression, and the AKT inhibitor LY294002 counteracted the effect of CXCL6 recombinant proteins on Sirt3, p-AKT, and p-FOXO3a expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	C-X-C motif chemokine ligand 6	Homo sapiens	185-190
33241954-5	2021	In addition, CXCL6-induced HBMEC permeability and inhibition of HBMEC proliferation were counteracted by Sirt3 overexpression, and the AKT inhibitor LY294002 counteracted the effect of CXCL6 recombinant proteins on Sirt3, p-AKT, and p-FOXO3a expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	sirtuin 3	Homo sapiens	215-220
33241954-5	2021	In addition, CXCL6-induced HBMEC permeability and inhibition of HBMEC proliferation were counteracted by Sirt3 overexpression, and the AKT inhibitor LY294002 counteracted the effect of CXCL6 recombinant proteins on Sirt3, p-AKT, and p-FOXO3a expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	AKT serine/threonine kinase 1	Homo sapiens	224-227
32393798-7	2021	In addition, blocking PI3K/Akt pathway using LY294002 partially counteracted the cell viability-enhancing effect of JE-133.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	27-30
33241954-5	2021	In addition, CXCL6-induced HBMEC permeability and inhibition of HBMEC proliferation were counteracted by Sirt3 overexpression, and the AKT inhibitor LY294002 counteracted the effect of CXCL6 recombinant proteins on Sirt3, p-AKT, and p-FOXO3a expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	forkhead box O3	Homo sapiens	235-241
32942336-10	2021	Inhibition of PI3K/AKT/mTOR signalling with LY294002 activated autophagy in clusterin-overexpressing GC-1 spg cells under high glucose conditions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	thymoma viral proto-oncogene 1	Mus musculus	19-22
33706561-11	2021	Meanwhile, the inhibition of glioma cell proliferation and invasiveness induced by ANXA1 down-regulation was further enhanced by combined treatment with AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	annexin A1	Homo sapiens	83-88
33706561-11	2021	Meanwhile, the inhibition of glioma cell proliferation and invasiveness induced by ANXA1 down-regulation was further enhanced by combined treatment with AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	AKT serine/threonine kinase 1	Homo sapiens	153-156
32942336-10	2021	Inhibition of PI3K/AKT/mTOR signalling with LY294002 activated autophagy in clusterin-overexpressing GC-1 spg cells under high glucose conditions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	mechanistic target of rapamycin kinase	Mus musculus	23-27
32942336-10	2021	Inhibition of PI3K/AKT/mTOR signalling with LY294002 activated autophagy in clusterin-overexpressing GC-1 spg cells under high glucose conditions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	clusterin	Mus musculus	76-85
32942336-11	2021	Clusterin overexpression repressed autophagy and alleviated testicular damage in diabetic rats, which was also abrogated by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	clusterin	Rattus norvegicus	0-9
33492283-7	2021	RESULTS: Compared with group CON, group IMA, and group LY294002, alpha-SMA was upregulated in group PDGF-BB (p< 0.05), with higher OD490 nm value (p< 0.05), narrower average scratch width, and higher relative cell migration rate (p< 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	actin alpha 1, skeletal muscle	Homo sapiens	65-74
33212374-9	2021	Additionally, our experiments where specific inhibitors of MEK (U0126) and PI3K (LY294002) were utilized verified that BR enhanced cell proliferation and wound healing through stimulating the MAPK and PI3K/Akt signal transduction pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	206-209
32668051-9	2021	Then the antagonist of Akt phosphorylation (LY294002) was used to treat AD mice, which could rescue the expression of CLDN1 through inhibiting the Akt phosphorylation in skin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	thymoma viral proto-oncogene 1	Mus musculus	23-26
33853342-9	2021	Additionally, inhibition of Akt by LY294002 reversed the effects of FBXO17 overexpression on cellular behaviors of glioma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	28-31
33853342-9	2021	Additionally, inhibition of Akt by LY294002 reversed the effects of FBXO17 overexpression on cellular behaviors of glioma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	F-box protein 17	Homo sapiens	68-74
32668051-9	2021	Then the antagonist of Akt phosphorylation (LY294002) was used to treat AD mice, which could rescue the expression of CLDN1 through inhibiting the Akt phosphorylation in skin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	claudin 1	Mus musculus	118-123
32668051-9	2021	Then the antagonist of Akt phosphorylation (LY294002) was used to treat AD mice, which could rescue the expression of CLDN1 through inhibiting the Akt phosphorylation in skin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	thymoma viral proto-oncogene 1	Mus musculus	147-150
31462074-7	2021	After inhibition of PI3K/Akt pathway by PI3K inhibitor LY294002, the levels of IL-25 and IL-17RB and HIF-1alpha were decreased by LPS stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	25-28
33273969-7	2021	Furthermore, SDF-1-induced EPC proliferation was significantly reduced following treatment with a C-X-C Motif Chemokine Receptor 4 antagonist (AMD3100), a PI3K inhibitor (LY294002) and the mitogen-activated protein kinase kinase inhibitor (MEK; PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	C-X-C motif chemokine ligand 12	Homo sapiens	13-18
33273980-8	2021	Further, the Klotho protein expression of the pDC316-Klotho group was significantly upregulated and the Nrf-2 and ARE proteins expressions of the LY294002 and pDC316-Klotho groups were significantly suppressed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	NFE2 like bZIP transcription factor 2	Rattus norvegicus	104-109
33273969-9	2021	Moreover, SDF-1 significantly increased the protein expression levels of phosphorylated (p)-Akt and p-ERK; however, SDF-1-induced effects on protein expression were suppressed by AMD3100, LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	C-X-C motif chemokine ligand 12	Homo sapiens	10-15
33273969-9	2021	Moreover, SDF-1 significantly increased the protein expression levels of phosphorylated (p)-Akt and p-ERK; however, SDF-1-induced effects on protein expression were suppressed by AMD3100, LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	C-X-C motif chemokine ligand 12	Homo sapiens	116-121
33660537-9	2021	Intrathecal injection of LY294002 attenuated the development of morphine tolerance and downregulated the protein expression of p-Akt, p-JNK1/2, and beta-arrestin2 in the spinal dorsal horn of rats with bone cancer pain-morphine tolerance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	arrestin, beta 2, pseudogene	Rattus norvegicus	148-162
33277741-6	2021	In addition, inhibition of autophagy using the PI3K inhibitor LY294002 did not rescues OPG-mediated suppression of osteoclastogenesis, but caused reduction of the expression of c-Fos and CAII by attenuating the autophagy, as well as the PI3K/Akt and the TAK1/S6 signalling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	177-182
33577052-10	2021	LY294002 remarkably inhibited the protective effect of SEV against myocardial injury (p<0.01) CONCLUSIONS: SEV is able to prominently ameliorate ADR-induced myocardial injury by regulating the phosphorylation level of the PI3K/Akt/GSK-3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	227-230
33577052-10	2021	LY294002 remarkably inhibited the protective effect of SEV against myocardial injury (p<0.01) CONCLUSIONS: SEV is able to prominently ameliorate ADR-induced myocardial injury by regulating the phosphorylation level of the PI3K/Akt/GSK-3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 alpha	Rattus norvegicus	231-240
33391425-4	2021	HnRNP-F expression was significantly decreased by treatment with the PI3K/AKT signalling pathway inhibitor LY294002, whereas hnRNP-F knockdown did not significantly affect PI3K or AKT expression, suggesting that hnRNP-F is likely a downstream target of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	heterogeneous nuclear ribonucleoprotein F	Homo sapiens	0-7
33391425-4	2021	HnRNP-F expression was significantly decreased by treatment with the PI3K/AKT signalling pathway inhibitor LY294002, whereas hnRNP-F knockdown did not significantly affect PI3K or AKT expression, suggesting that hnRNP-F is likely a downstream target of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	AKT serine/threonine kinase 1	Homo sapiens	74-77
33391425-4	2021	HnRNP-F expression was significantly decreased by treatment with the PI3K/AKT signalling pathway inhibitor LY294002, whereas hnRNP-F knockdown did not significantly affect PI3K or AKT expression, suggesting that hnRNP-F is likely a downstream target of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	heterogeneous nuclear ribonucleoprotein F	Homo sapiens	212-219
33277741-6	2021	In addition, inhibition of autophagy using the PI3K inhibitor LY294002 did not rescues OPG-mediated suppression of osteoclastogenesis, but caused reduction of the expression of c-Fos and CAII by attenuating the autophagy, as well as the PI3K/Akt and the TAK1/S6 signalling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	carbonic anhydrase 2	Homo sapiens	187-191
33035625-10	2021	Furthermore, IGF-1 treatment alone increased the expression of GPER, which was blocked by JB-1, the phosphatidylinositol 3-kinase (PI3-K) antagonist LY294002 and the MEK antagonist PD98059 in primary astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	insulin like growth factor 1	Homo sapiens	13-18
33035625-10	2021	Furthermore, IGF-1 treatment alone increased the expression of GPER, which was blocked by JB-1, the phosphatidylinositol 3-kinase (PI3-K) antagonist LY294002 and the MEK antagonist PD98059 in primary astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	G protein-coupled estrogen receptor 1	Homo sapiens	63-67
33411234-12	2021	The PI3K-pathway inhibitor LY294002 reduced IL8-induced MMP2 release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	matrix metallopeptidase 2	Homo sapiens	56-60
33039386-15	2020	P-c-Met overexpression resulted in activation of the PI3K/Akt pathway, and inhibition of PI3K/Akt signaling with LY294002 reversed chemoresistance and EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Homo sapiens	94-97
33291121-10	2021	The expression level of p-AKT/AKT, PI3K, PDK1, Skp2, and p27 in OA group, LY294002 group, and OA combined with LY294002 group was significantly lower than that in the RIRI model group, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Rattus norvegicus	26-29
33291121-10	2021	The expression level of p-AKT/AKT, PI3K, PDK1, Skp2, and p27 in OA group, LY294002 group, and OA combined with LY294002 group was significantly lower than that in the RIRI model group, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	57-60
33291121-10	2021	The expression level of p-AKT/AKT, PI3K, PDK1, Skp2, and p27 in OA group, LY294002 group, and OA combined with LY294002 group was significantly lower than that in the RIRI model group, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Rattus norvegicus	26-29
33291121-10	2021	The expression level of p-AKT/AKT, PI3K, PDK1, Skp2, and p27 in OA group, LY294002 group, and OA combined with LY294002 group was significantly lower than that in the RIRI model group, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Rattus norvegicus	30-33
33291121-10	2021	The expression level of p-AKT/AKT, PI3K, PDK1, Skp2, and p27 in OA group, LY294002 group, and OA combined with LY294002 group was significantly lower than that in the RIRI model group, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	57-60
33361699-6	2021	The increase in the mPSC frequency was prevented by the use of IGF-1R antagonist, JB1 (1 microM) or the intracellularly applied PI3K blocker (LY294002, 50 microM) showing involvement of IGF-1R and PI3K in the mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	insulin-like growth factor I receptor	Mus musculus	186-192
33167006-6	2020	Moreover, we presumed that LY294002, an inhibitor of the PI3K/AKT pathway, may enhance the cytotoxic effects of cisplatin through upregulating FOXO1 and FOXO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	62-65
33167006-6	2020	Moreover, we presumed that LY294002, an inhibitor of the PI3K/AKT pathway, may enhance the cytotoxic effects of cisplatin through upregulating FOXO1 and FOXO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	forkhead box O1	Homo sapiens	143-148
33167006-6	2020	Moreover, we presumed that LY294002, an inhibitor of the PI3K/AKT pathway, may enhance the cytotoxic effects of cisplatin through upregulating FOXO1 and FOXO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	forkhead box O3	Homo sapiens	153-159
33167006-11	2020	Mechanistically, LY294002 increased the expressions and nuclear accumulation of FOXO1 and FOXO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	forkhead box O1	Homo sapiens	80-85
33167006-11	2020	Mechanistically, LY294002 increased the expressions and nuclear accumulation of FOXO1 and FOXO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	forkhead box O3	Homo sapiens	90-96
33167006-12	2020	Knockdown of FOXO1 and FOXO3a abrogated the enhancing effect of LY294002 on cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	forkhead box O1	Homo sapiens	13-18
33167006-12	2020	Knockdown of FOXO1 and FOXO3a abrogated the enhancing effect of LY294002 on cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	forkhead box O3	Homo sapiens	23-29
33167006-13	2020	Taken together, our results suggested that FOXO1 and FOXO3a sensitize NSCLC cells to cisplatin and mediate the enhancing effects of LY294002 on cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	forkhead box O1	Homo sapiens	43-48
33167006-13	2020	Taken together, our results suggested that FOXO1 and FOXO3a sensitize NSCLC cells to cisplatin and mediate the enhancing effects of LY294002 on cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	forkhead box O3	Homo sapiens	53-59
33319361-6	2021	Such leptin"s suppression of sucrose responses was impaired by co-administration of PI3K inhibitors (wortmannin or LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	leptin	Mus musculus	5-11
33308227-9	2020	Both alpha and gamma-ENaC protein expressions were increased after AT2 cells were transfected with siPTEN, which could be reversed by the co-administration of PI3K/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	21-25
33319361-9	2021	Leptin-induced PIP3 production was suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	leptin	Mus musculus	0-6
33317626-15	2020	Additionally, ELA treatment induced the phosphorylation of AKT and ERK, while the blockade of PI3K/AKT and ERK1/2 pathways with respective inhibitors, LY294002 and U0126, suppressed the action of ELA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	AKT serine/threonine kinase 1	Homo sapiens	99-102
33317626-15	2020	Additionally, ELA treatment induced the phosphorylation of AKT and ERK, while the blockade of PI3K/AKT and ERK1/2 pathways with respective inhibitors, LY294002 and U0126, suppressed the action of ELA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	mitogen-activated protein kinase 3	Homo sapiens	107-113
33349309-8	2020	These effects were inversed after pretreatment of the PI3K/Akt inhibitor LY294002 or overexpression of constitutively active Akt1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	thymoma viral proto-oncogene 1	Mus musculus	59-62
33308227-9	2020	Both alpha and gamma-ENaC protein expressions were increased after AT2 cells were transfected with siPTEN, which could be reversed by the co-administration of PI3K/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	AKT serine/threonine kinase 1	Homo sapiens	164-167
33372619-12	2020	Additionally, treatment with LY294002 inhibitor revealed the involvement of the Akt/FOXO1/Bim signaling pathway in folate deficiency-induced apoptosis, rather than the ERK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	thymoma viral proto-oncogene 1	Mus musculus	80-83
33372619-12	2020	Additionally, treatment with LY294002 inhibitor revealed the involvement of the Akt/FOXO1/Bim signaling pathway in folate deficiency-induced apoptosis, rather than the ERK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	forkhead box O1	Mus musculus	84-89
33372619-12	2020	Additionally, treatment with LY294002 inhibitor revealed the involvement of the Akt/FOXO1/Bim signaling pathway in folate deficiency-induced apoptosis, rather than the ERK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	BCL2-like 11 (apoptosis facilitator)	Mus musculus	90-93
33290750-9	2020	Furthermore, LY294002, the PI3K/Akt pathway inhibitor, could reverse the effect of si-ARID1A on the ovarian GCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	32-35
33343353-9	2020	The use of the specific PI3K/AKT pathway inhibitor LY294002 regressed the cardio-protection of GSPE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	thymoma viral proto-oncogene 1	Mus musculus	29-32
33291082-6	2020	Moreover, AIM2 could modulate Protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway and the increased Gli1 expression and EMT progress induced by AIM2 depletion was reversed after incubation with AKT inhibitor Ly294002 in CRC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	236-244	mechanistic target of rapamycin kinase	Homo sapiens	53-84
33291082-6	2020	Moreover, AIM2 could modulate Protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway and the increased Gli1 expression and EMT progress induced by AIM2 depletion was reversed after incubation with AKT inhibitor Ly294002 in CRC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	236-244	GLI family zinc finger 1	Homo sapiens	128-132
33291082-6	2020	Moreover, AIM2 could modulate Protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway and the increased Gli1 expression and EMT progress induced by AIM2 depletion was reversed after incubation with AKT inhibitor Ly294002 in CRC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	236-244	absent in melanoma 2	Homo sapiens	172-176
33291082-6	2020	Moreover, AIM2 could modulate Protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway and the increased Gli1 expression and EMT progress induced by AIM2 depletion was reversed after incubation with AKT inhibitor Ly294002 in CRC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	236-244	AKT serine/threonine kinase 1	Homo sapiens	222-225
32997750-12	2020	ASIC3 expression and incisional pain-related behaviors were inhibited by pretreatment with the phosphoinositide 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	acid sensing ion channel subunit 3	Rattus norvegicus	0-5
33291082-6	2020	Moreover, AIM2 could modulate Protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway and the increased Gli1 expression and EMT progress induced by AIM2 depletion was reversed after incubation with AKT inhibitor Ly294002 in CRC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	236-244	absent in melanoma 2	Homo sapiens	10-14
33290750-9	2020	Furthermore, LY294002, the PI3K/Akt pathway inhibitor, could reverse the effect of si-ARID1A on the ovarian GCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AT rich interactive domain 1A (SWI-like)	Mus musculus	86-92
33193844-13	2020	Moreover, miR-342-5p mimics partially activated the Akt signaling pathway inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	microRNA 342	Mus musculus	10-17
33127342-7	2020	Additionally, LY294002 significantly reduced the expression of SETD8, pAkt-Ser473, pPI3K-p85, and NFkappaB-p65 in MKN74 and MKN28 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	lysine methyltransferase 5A	Homo sapiens	63-68
33127342-7	2020	Additionally, LY294002 significantly reduced the expression of SETD8, pAkt-Ser473, pPI3K-p85, and NFkappaB-p65 in MKN74 and MKN28 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	98-110
33193844-13	2020	Moreover, miR-342-5p mimics partially activated the Akt signaling pathway inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	thymoma viral proto-oncogene 1	Mus musculus	52-55
33145952-12	2020	The PI3K/AKT inhibitor LY294002 prevented SLC1A3-induced glucose metabolism and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	thymoma viral proto-oncogene 1	Mus musculus	9-12
32215966-8	2020	LY294002, a PI3K inhibitor, significantly inhibited CBD-induced autophagy, demonstrating that PI3K/AKT signaling is involved in the CBD"s regulation of autophagy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	99-102
33039957-3	2020	LY294002 was used as an inhibitor of PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	42-45
33039957-11	2020	Blockade of p-FoxO3a activation by LY294002 suppressed PI3K/Akt/FoxO3a pathway and the subsequent upregulation of FoxO3a in the nucleus resulting in the severity of inflammation and fibrosis in the kidney of MRL/lpr mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	forkhead box O3	Mus musculus	14-20
33039957-11	2020	Blockade of p-FoxO3a activation by LY294002 suppressed PI3K/Akt/FoxO3a pathway and the subsequent upregulation of FoxO3a in the nucleus resulting in the severity of inflammation and fibrosis in the kidney of MRL/lpr mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	thymoma viral proto-oncogene 1	Mus musculus	60-63
33039957-11	2020	Blockade of p-FoxO3a activation by LY294002 suppressed PI3K/Akt/FoxO3a pathway and the subsequent upregulation of FoxO3a in the nucleus resulting in the severity of inflammation and fibrosis in the kidney of MRL/lpr mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	forkhead box O3	Mus musculus	64-70
33039957-11	2020	Blockade of p-FoxO3a activation by LY294002 suppressed PI3K/Akt/FoxO3a pathway and the subsequent upregulation of FoxO3a in the nucleus resulting in the severity of inflammation and fibrosis in the kidney of MRL/lpr mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	forkhead box O3	Mus musculus	64-70
33039957-11	2020	Blockade of p-FoxO3a activation by LY294002 suppressed PI3K/Akt/FoxO3a pathway and the subsequent upregulation of FoxO3a in the nucleus resulting in the severity of inflammation and fibrosis in the kidney of MRL/lpr mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	Fas (TNF receptor superfamily member 6)	Mus musculus	212-215
32495363-8	2020	Blocking the PI3K/Akt pathway by Ly294002 inhibited HK2 activities, aerobic glycolysis, and cell proliferation in FoxA2-knockdown cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
32495363-8	2020	Blocking the PI3K/Akt pathway by Ly294002 inhibited HK2 activities, aerobic glycolysis, and cell proliferation in FoxA2-knockdown cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	hexokinase 2	Rattus norvegicus	52-55
32495363-8	2020	Blocking the PI3K/Akt pathway by Ly294002 inhibited HK2 activities, aerobic glycolysis, and cell proliferation in FoxA2-knockdown cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	forkhead box A2	Rattus norvegicus	114-119
33145952-12	2020	The PI3K/AKT inhibitor LY294002 prevented SLC1A3-induced glucose metabolism and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	42-48
33075233-6	2020	Moreover, when cells were pretreated with Ro 32-0432 (an inhibitor of calcium-dependent PKC) and LY294002 (a PI3K inhibitor), this also resulted in a down-regulation of any Cd-induced CCL2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	C-C motif chemokine ligand 2	Homo sapiens	184-188
33253601-10	2020	However, these changes were reversed by the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Rattus norvegicus	49-52
32729224-13	2020	However, the expression of TGF-beta1, Akt, and alpha-SMA were significantly decreased in PI3K/Akt signal pathway inhibitor LY294002-treated group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	transforming growth factor, beta 1	Rattus norvegicus	27-36
32729224-13	2020	However, the expression of TGF-beta1, Akt, and alpha-SMA were significantly decreased in PI3K/Akt signal pathway inhibitor LY294002-treated group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	AKT serine/threonine kinase 1	Rattus norvegicus	38-41
32729224-13	2020	However, the expression of TGF-beta1, Akt, and alpha-SMA were significantly decreased in PI3K/Akt signal pathway inhibitor LY294002-treated group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	AKT serine/threonine kinase 1	Rattus norvegicus	94-97
33173956-5	2020	Additionally, the PI3K/AKT inhibitor LY294002 was also used in mechanistic experiments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	23-26
33174025-14	2020	Most importantly, treatment with the Akt inhibitor LY294002 in WT mice blocked the hepatoprotective effects of HDN in liver I/R injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	thymoma viral proto-oncogene 1	Mus musculus	37-40
33293832-12	2020	Treatment with PI3K inhibitor LY294002 blocked the effects of ADORA1 on tumor growth in either ADORA1-overexpressing or -deficiency cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	adenosine A1 receptor	Homo sapiens	62-68
33293832-12	2020	Treatment with PI3K inhibitor LY294002 blocked the effects of ADORA1 on tumor growth in either ADORA1-overexpressing or -deficiency cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	adenosine A1 receptor	Homo sapiens	95-101
33299325-13	2020	Notably, the effect of NUPR1 overexpression in A2780 cells could be partially or completely eliminated by treatment with the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	nuclear protein 1, transcriptional regulator	Homo sapiens	23-28
33112769-8	2020	After PI3K specific-inhibitor LY294002 intervention, mRNA expressions of Lhcgr and Hsd32 were partially-rescued in Bmal1 interference TCs, together with significantly increased androstenedione and T synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	luteinizing hormone/choriogonadotropin receptor	Mus musculus	73-78
33112769-8	2020	After PI3K specific-inhibitor LY294002 intervention, mRNA expressions of Lhcgr and Hsd32 were partially-rescued in Bmal1 interference TCs, together with significantly increased androstenedione and T synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	115-120
33299325-13	2020	Notably, the effect of NUPR1 overexpression in A2780 cells could be partially or completely eliminated by treatment with the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Homo sapiens	125-128
33244935-6	2020	We found that phosphorylation levels of eIF4B in acute leukemia cells were significantly reduced in response to treatment with either LY294002 (PI3K inhibitor), AKTi (AKT inhibitor) or SMI-4A (Pim inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	eukaryotic translation initiation factor 4B	Homo sapiens	40-45
33231603-6	2020	Transwell assays were used to examine the changes in cell motility after alterations in ARHGEF39 expression and treatment with LY294002 (an AKT inhibitor) or PD98059 (an ERK inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	140-143
33148324-14	2020	Conversely, the antioxidant effects of hPMSCs were blocked by the Akt inhibitor LY294002 and Nrf2 inhibitor ML385 in senescent CD4+ T cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	66-69
33212946-7	2020	Moreover, we found that this pathway is involved in HGF-dependent NT2D1 cell proliferation, migration, and invasion, since the co-administration of the PI3K inhibitor LY294002 together with HGF abrogates these responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	hepatocyte growth factor	Homo sapiens	52-55
33312368-9	2020	The AKT pathway was blocked by LY294002 treatment and then the cell activities were assessed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	4-7
33312368-15	2020	LY294002 treatment recovered the decreases of colony formation and cell proliferation, arrest of cell cycle and increase of cell apoptosis which were induced by WISP1 knockdown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cellular communication network factor 4	Homo sapiens	161-166
33274009-6	2020	Mc1r siRNA and PI3K inhibitor LY294002 were administrated to inhibit the expression of Mc1r and phosphorylation of PI3K, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	melanocortin 1 receptor	Mus musculus	87-91
32946868-10	2020	Furthermore, administration of the PI3K/AKT signaling pathway inhibitor LY294002 abolished the beneficial effects of ECT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	40-43
33173334-5	2020	The PI3K/AKT signaling pathway was interfered with L740Y-P (activator of the PI3K/AKT pathway) and LY294002 (inhibitor of the PI3K/AKT pathway) in BC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	thymoma viral proto-oncogene 1	Mus musculus	9-12
33173334-10	2020	740Y-P intervention could reverse the inhibition effect of Si-SOX21-AS1 on BC cell proliferation, invasion, migration, and EMT, while LY294002 intervention could reverse the promotion effect of Sh-SOX21-AS1 on BC cell proliferation, invasion, migration, and EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	SRY (sex determining region Y)-box 21	Mus musculus	197-202
33173334-10	2020	740Y-P intervention could reverse the inhibition effect of Si-SOX21-AS1 on BC cell proliferation, invasion, migration, and EMT, while LY294002 intervention could reverse the promotion effect of Sh-SOX21-AS1 on BC cell proliferation, invasion, migration, and EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	arylsulfatase B	Mus musculus	203-206
32668495-9	2020	LY294002 (the inhibitor of the PI3K/AKT signalling pathway) could reverse the facilitating effects of IL-17F treatment on PCa cell viability, proliferation, migration, invasion and stemness.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	36-39
32668495-9	2020	LY294002 (the inhibitor of the PI3K/AKT signalling pathway) could reverse the facilitating effects of IL-17F treatment on PCa cell viability, proliferation, migration, invasion and stemness.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 17F	Homo sapiens	102-108
32777676-6	2020	Furthermore, LY294002, an inhibitor for PI3K, abrogated serum-induced phosphorylation of Akt, and decreased the proliferation of ASMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	thymoma viral proto-oncogene 1	Mus musculus	89-92
32827692-6	2020	These beneficial effects of HGF were blocked by HGF/c-Met inhibitor Crizotinib or phosphatidylinositide 3-kinases (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	hepatocyte growth factor	Mus musculus	28-31
33047116-17	2020	Western blot analysis of the rescue experiments performed using the phosphatidylinositol 3-kinase (PI3K) signaling-specific inhibitor LY294002 was used to investigate the downstream signaling pathways through which OPG could mediate HESC decidualization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	TNF receptor superfamily member 11b	Homo sapiens	215-218
33334784-6	2020	Inhibition of Akt with LY294002 significantly increased Btg2 mRNA expression while activation of Akt with insulin decreased Btg2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	14-17
33334784-6	2020	Inhibition of Akt with LY294002 significantly increased Btg2 mRNA expression while activation of Akt with insulin decreased Btg2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	BTG anti-proliferation factor 2	Homo sapiens	56-60
33334784-8	2020	Moreover, LY294002 treatment increased Erk1/2 activation, decreased cells proliferation and cells viability while activation of Akt by insulin led to an increase in cells survival and cells division.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	mitogen-activated protein kinase 3	Homo sapiens	39-45
31931659-12	2020	Collectively, our results identify ROS as central inducers of MTORC2 activation during chronic autophagy, which in turn fuels senescence activation and myofibroblast differentiation in distinct cellular subpopulations.Abbreviations: 3-MA: 3-methyladenine; ACTA2: actin, alpha 2, smooth muscle, aorta; AKT1: AKT serine/threonine kinase 1; p-AKT1: AKT1 Ser473 phosphorylation; t-AKT1: total AKT serine/threonine kinase 1; ATG4A: autophagy related 4A cysteine peptidase; ATG7: autophagy gene 7; C12FDG: 5-dodecanoylaminofluorescein Di-beta-D-Galactopyranoside; CDKN1A: cyclin dependent kinase inhibitor 1A; CDKN2A: cyclin dependent kinase inhibitor 2A; Ctl: control; DAPI: 4",6-diamidino-2-phenylindole, dilactate; ECM: extracellular matrix; GSH: L-glutathione reduced; H2O2: hydrogen peroxide; HLF: adult human lung fibroblasts; Ho: Hoechst 33342 (2"-[4-ethoxyphenyl]-5-[4-methyl-1-piperazinyl]-2.5"-bi-1H-benzimidazole); HSC: hepatic stellate cells; LY: LY294002; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTORC1/2: mechanistic target of rapamycin kinase complex 1/2; N: normal growth medium; NAC: N-acetyl-L-cysteine; PBS: phosphate-buffered saline; PDGFA: platelet derived growth factor subunit A; PRKCA/PKCalpha: protein kinase C alpha; PtdIns3K: class III phosphatidylinositol 3-kinase; PTEN: phosphatase and tensin homolog; R: rapamycin; RICTOR: RPTOR independent companion of MTOR complex 2; ROS: reactive oxygen species; RPTOR: regulatory associated protein of MTOR complex 1; SA-GLB1/beta-gal: senescence-associated galactosidase beta 1; SGK1: serum/glucocorticoid regulated kinase 1; shRNA: short hairpin RNA; siCtl: control siRNA; siRNA: small interfering RNA; SQSTM1: sequestosome 1; SS: serum-free (serum starvation) medium; TP53: tumor protein p53; TUBA: tubulin alpha; V: vehicle.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	953-961	mechanistic target of rapamycin kinase	Homo sapiens	62-66
32394671-6	2020	Co-treatment with LY294002 decreased the aphidicolin-stimulated increase in p-CREB-Ser133 level, eNOS expression, and NO production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	cAMP responsive element binding protein 1	Bos taurus	78-82
32394671-6	2020	Co-treatment with LY294002 decreased the aphidicolin-stimulated increase in p-CREB-Ser133 level, eNOS expression, and NO production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	nitric oxide synthase 3	Bos taurus	97-101
32877639-8	2020	Mechanistically, PP9-suppressed PI3K/Akt/GSK3beta signaling, while the PI3K inhibitor LY294002 augmented PP9-mediated apoptosis, G2/M arrest and effects on PI3K/Akt/GSK3beta related proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	AKT serine/threonine kinase 1	Homo sapiens	161-164
32877639-8	2020	Mechanistically, PP9-suppressed PI3K/Akt/GSK3beta signaling, while the PI3K inhibitor LY294002 augmented PP9-mediated apoptosis, G2/M arrest and effects on PI3K/Akt/GSK3beta related proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	glycogen synthase kinase 3 alpha	Homo sapiens	165-173
32871684-7	2020	RESULT: Our results showed that the decreasing effects of CUMS and CSDS on the mTORC1 signaling cascade in the hippocampus and mPFC were restored by venlafaxine, and the use of rapamycin, LY294002, U0126 and mTORC1-shRNA fully abolished the anti-stress actions of venlafaxine in mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	CREB regulated transcription coactivator 1	Mus musculus	79-85
32070170-7	2020	Interestingly, the levels ofboth phosphorylated Ser473-Akt and phosphorylated Ser9-GSK-3beta were increased by glucocorticoid and IGF-1 cotreatment.Pharmacological manipulation with LY294002 and LiCl was employed to inhibit Akt and GSK-3beta, respectively.We found that cellular differentiability was inhibited by LY294002 and enhanced by LiCl, indicating that theAkt/GSK-3beta signaling pathway is activated by glucocorticoid and IGF-1 treatment to promote myogenic differentiation.Conclusions: Glucocorticoids together with IGF-1 promote myogenic differentiation through the Akt/GSK-3betapathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	glycogen synthase kinase 3 alpha	Homo sapiens	83-92
32070170-7	2020	Interestingly, the levels ofboth phosphorylated Ser473-Akt and phosphorylated Ser9-GSK-3beta were increased by glucocorticoid and IGF-1 cotreatment.Pharmacological manipulation with LY294002 and LiCl was employed to inhibit Akt and GSK-3beta, respectively.We found that cellular differentiability was inhibited by LY294002 and enhanced by LiCl, indicating that theAkt/GSK-3beta signaling pathway is activated by glucocorticoid and IGF-1 treatment to promote myogenic differentiation.Conclusions: Glucocorticoids together with IGF-1 promote myogenic differentiation through the Akt/GSK-3betapathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	insulin like growth factor 1	Homo sapiens	130-135
32070170-7	2020	Interestingly, the levels ofboth phosphorylated Ser473-Akt and phosphorylated Ser9-GSK-3beta were increased by glucocorticoid and IGF-1 cotreatment.Pharmacological manipulation with LY294002 and LiCl was employed to inhibit Akt and GSK-3beta, respectively.We found that cellular differentiability was inhibited by LY294002 and enhanced by LiCl, indicating that theAkt/GSK-3beta signaling pathway is activated by glucocorticoid and IGF-1 treatment to promote myogenic differentiation.Conclusions: Glucocorticoids together with IGF-1 promote myogenic differentiation through the Akt/GSK-3betapathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	glycogen synthase kinase 3 alpha	Homo sapiens	232-241
32070170-7	2020	Interestingly, the levels ofboth phosphorylated Ser473-Akt and phosphorylated Ser9-GSK-3beta were increased by glucocorticoid and IGF-1 cotreatment.Pharmacological manipulation with LY294002 and LiCl was employed to inhibit Akt and GSK-3beta, respectively.We found that cellular differentiability was inhibited by LY294002 and enhanced by LiCl, indicating that theAkt/GSK-3beta signaling pathway is activated by glucocorticoid and IGF-1 treatment to promote myogenic differentiation.Conclusions: Glucocorticoids together with IGF-1 promote myogenic differentiation through the Akt/GSK-3betapathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	glycogen synthase kinase 3 alpha	Homo sapiens	232-241
32070170-7	2020	Interestingly, the levels ofboth phosphorylated Ser473-Akt and phosphorylated Ser9-GSK-3beta were increased by glucocorticoid and IGF-1 cotreatment.Pharmacological manipulation with LY294002 and LiCl was employed to inhibit Akt and GSK-3beta, respectively.We found that cellular differentiability was inhibited by LY294002 and enhanced by LiCl, indicating that theAkt/GSK-3beta signaling pathway is activated by glucocorticoid and IGF-1 treatment to promote myogenic differentiation.Conclusions: Glucocorticoids together with IGF-1 promote myogenic differentiation through the Akt/GSK-3betapathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	insulin like growth factor 1	Homo sapiens	431-436
32070170-7	2020	Interestingly, the levels ofboth phosphorylated Ser473-Akt and phosphorylated Ser9-GSK-3beta were increased by glucocorticoid and IGF-1 cotreatment.Pharmacological manipulation with LY294002 and LiCl was employed to inhibit Akt and GSK-3beta, respectively.We found that cellular differentiability was inhibited by LY294002 and enhanced by LiCl, indicating that theAkt/GSK-3beta signaling pathway is activated by glucocorticoid and IGF-1 treatment to promote myogenic differentiation.Conclusions: Glucocorticoids together with IGF-1 promote myogenic differentiation through the Akt/GSK-3betapathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	insulin like growth factor 1	Homo sapiens	431-436
32070170-7	2020	Interestingly, the levels ofboth phosphorylated Ser473-Akt and phosphorylated Ser9-GSK-3beta were increased by glucocorticoid and IGF-1 cotreatment.Pharmacological manipulation with LY294002 and LiCl was employed to inhibit Akt and GSK-3beta, respectively.We found that cellular differentiability was inhibited by LY294002 and enhanced by LiCl, indicating that theAkt/GSK-3beta signaling pathway is activated by glucocorticoid and IGF-1 treatment to promote myogenic differentiation.Conclusions: Glucocorticoids together with IGF-1 promote myogenic differentiation through the Akt/GSK-3betapathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	AKT serine/threonine kinase 1	Homo sapiens	224-227
32070170-7	2020	Interestingly, the levels ofboth phosphorylated Ser473-Akt and phosphorylated Ser9-GSK-3beta were increased by glucocorticoid and IGF-1 cotreatment.Pharmacological manipulation with LY294002 and LiCl was employed to inhibit Akt and GSK-3beta, respectively.We found that cellular differentiability was inhibited by LY294002 and enhanced by LiCl, indicating that theAkt/GSK-3beta signaling pathway is activated by glucocorticoid and IGF-1 treatment to promote myogenic differentiation.Conclusions: Glucocorticoids together with IGF-1 promote myogenic differentiation through the Akt/GSK-3betapathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	314-322	insulin like growth factor 1	Homo sapiens	130-135
32507927-4	2020	We also observed and evaluated the changes in the above results after administration of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway protein inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	92-121
32507927-4	2020	We also observed and evaluated the changes in the above results after administration of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway protein inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	AKT serine/threonine kinase 1	Rattus norvegicus	147-150
32507927-9	2020	Western blotting results showed that one week after intraperitoneal injection of MB, the expression of t-Akt and p-Akt in the CCH + MB group was increased after CCH, and LY294002 partially blocked this up-regulation effect (CCH + MB + LY294002 group).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Rattus norvegicus	105-108
32507927-9	2020	Western blotting results showed that one week after intraperitoneal injection of MB, the expression of t-Akt and p-Akt in the CCH + MB group was increased after CCH, and LY294002 partially blocked this up-regulation effect (CCH + MB + LY294002 group).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Rattus norvegicus	115-118
33162828-11	2020	Inhibition of VEGFR2 by siRNA or XL184 (cabozantinib) and inhibition of downstream signaling by LY294002 (inhibits AKT activation) and L-NAME (eNOS inhibitor) remarkably abolished proangiogenic effects of CD137 signaling both in vitro and ex vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	thymoma viral proto-oncogene 1	Mus musculus	115-118
32507927-9	2020	Western blotting results showed that one week after intraperitoneal injection of MB, the expression of t-Akt and p-Akt in the CCH + MB group was increased after CCH, and LY294002 partially blocked this up-regulation effect (CCH + MB + LY294002 group).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	235-243	AKT serine/threonine kinase 1	Rattus norvegicus	105-108
32507927-9	2020	Western blotting results showed that one week after intraperitoneal injection of MB, the expression of t-Akt and p-Akt in the CCH + MB group was increased after CCH, and LY294002 partially blocked this up-regulation effect (CCH + MB + LY294002 group).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	235-243	AKT serine/threonine kinase 1	Rattus norvegicus	115-118
33162828-11	2020	Inhibition of VEGFR2 by siRNA or XL184 (cabozantinib) and inhibition of downstream signaling by LY294002 (inhibits AKT activation) and L-NAME (eNOS inhibitor) remarkably abolished proangiogenic effects of CD137 signaling both in vitro and ex vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	nitric oxide synthase 3, endothelial cell	Mus musculus	143-147
33065553-7	2020	This phenomenon can be abolished by applying the PI3K inhibitor LY294002, suggesting FoxO3a not only participates in TREM2-induced anti-inflammation response, but is also involved in regulating the phenotype of microglia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	forkhead box O3	Mus musculus	85-91
33085743-10	2020	Meanwhile, the application of PI3K inhibitor (LY294002) and PTEN overexpression attenuated the inhibition efficiency of NO66 on cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	ribosomal oxygenase 1	Homo sapiens	120-124
33065553-7	2020	This phenomenon can be abolished by applying the PI3K inhibitor LY294002, suggesting FoxO3a not only participates in TREM2-induced anti-inflammation response, but is also involved in regulating the phenotype of microglia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	triggering receptor expressed on myeloid cells 2	Mus musculus	117-122
33062046-5	2020	Results: Treatment with trilobatin prevented palmitate-induced insulin resistance by enhancing glucose uptake and the phosphorylation of insulin resistance substrate 1 (IRS1) and protein Kinase B, (PKB/AKT), recovered the translocation of GLUT4 from cytoplasm to membrane, but preincubation with LY294002, an inhibitor of PI3K, blocked the effects of trilobatin on glucose uptake and the distribution of GLUT4 in C2C12 myotubes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	296-304	insulin receptor substrate 1	Mus musculus	137-167
33067534-7	2020	Phosphoinositide 3-kinase (PI3K) inhibitor LY-294002 abolished SPARC-induced down-regulation of RGS4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-52	secreted acidic cysteine rich glycoprotein	Mus musculus	63-68
33067534-7	2020	Phosphoinositide 3-kinase (PI3K) inhibitor LY-294002 abolished SPARC-induced down-regulation of RGS4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-52	regulator of G-protein signaling 4	Mus musculus	96-100
33123919-2	2020	Here we analyze the effect of a specific PI3K/Akt pathway inhibitor (LY 294002) on the antidiabetic effect of the BDNF loop 1 mimetic GSB-214.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-78	thymoma viral proto-oncogene 1	Mus musculus	46-49
33037575-8	2021	Conversely, U0126 and LY294002, which respectively inhibited phosphorylation of ERK1/2 and Akt, partially prevented S727 phosphorylation, but had limited effects on the level of pY705, suggesting that phosphorylation of Y705 and S727 is regulated via independent mechanisms in FD-treated brains.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	mitogen-activated protein kinase 3	Homo sapiens	80-86
33037575-8	2021	Conversely, U0126 and LY294002, which respectively inhibited phosphorylation of ERK1/2 and Akt, partially prevented S727 phosphorylation, but had limited effects on the level of pY705, suggesting that phosphorylation of Y705 and S727 is regulated via independent mechanisms in FD-treated brains.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Homo sapiens	91-94
32679060-5	2020	Further, we found that glutathione peroxidase 4 (Gpx4) inhibition with RSL3, Akt inhibition with LY29400, and nuclear factor erythroid-2-related factor 2 (Nrf2) inhibition with ML385 abolished the Mel protective effects in HIBD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-104	AKT serine/threonine kinase 1	Rattus norvegicus	77-80
33023074-6	2020	Pretreatment with LY294002 (Akt inhibitor) and PD980559 (ERK inhibitor) inhibited LPS-induced Nrf2 nuclear translocation and HO-1 protein expression in ELF-EMF-exposed cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	28-31
33023074-6	2020	Pretreatment with LY294002 (Akt inhibitor) and PD980559 (ERK inhibitor) inhibited LPS-induced Nrf2 nuclear translocation and HO-1 protein expression in ELF-EMF-exposed cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
33023074-6	2020	Pretreatment with LY294002 (Akt inhibitor) and PD980559 (ERK inhibitor) inhibited LPS-induced Nrf2 nuclear translocation and HO-1 protein expression in ELF-EMF-exposed cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	heme oxygenase 1	Homo sapiens	125-129
33123919-2	2020	Here we analyze the effect of a specific PI3K/Akt pathway inhibitor (LY 294002) on the antidiabetic effect of the BDNF loop 1 mimetic GSB-214.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-78	brain derived neurotrophic factor	Mus musculus	114-118
33001018-9	2021	Treatment with the Akt inhibitor LY294002 partially reversed the protective effects of perampanel.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Homo sapiens	19-22
32829570-8	2020	Furthermore, LY294002 and idelalisib inhibited the phosphorylation of GSK-3beta and induced the nuclear translocation of GSK-3beta, which corresponded to the downregulation of Snail and beta-catenin expressions in Huh-BAT and HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	glycogen synthase kinase 3 alpha	Homo sapiens	70-79
32602017-8	2020	The NF-kappaB-specific small molecule inhibitor BAY 11-7082, prostaglandin E2, and LY294002 prevented hypoxia-induced EndMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	nuclear factor kappa B subunit 1	Homo sapiens	4-13
32829570-8	2020	Furthermore, LY294002 and idelalisib inhibited the phosphorylation of GSK-3beta and induced the nuclear translocation of GSK-3beta, which corresponded to the downregulation of Snail and beta-catenin expressions in Huh-BAT and HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	glycogen synthase kinase 3 alpha	Homo sapiens	121-130
32829570-8	2020	Furthermore, LY294002 and idelalisib inhibited the phosphorylation of GSK-3beta and induced the nuclear translocation of GSK-3beta, which corresponded to the downregulation of Snail and beta-catenin expressions in Huh-BAT and HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	snail family transcriptional repressor 1	Homo sapiens	176-181
32829570-8	2020	Furthermore, LY294002 and idelalisib inhibited the phosphorylation of GSK-3beta and induced the nuclear translocation of GSK-3beta, which corresponded to the downregulation of Snail and beta-catenin expressions in Huh-BAT and HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	catenin beta 1	Homo sapiens	186-198
32698024-11	2020	Furthermore, the increase in ALP activity, LRP5 and phospho-Akt/Akt expression by 8PG and genistein were abolished by co-treatment with LY294002 (10-5 M, a PI3K pathway inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	alopecia, recessive	Mus musculus	29-32
32698024-11	2020	Furthermore, the increase in ALP activity, LRP5 and phospho-Akt/Akt expression by 8PG and genistein were abolished by co-treatment with LY294002 (10-5 M, a PI3K pathway inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	low density lipoprotein receptor-related protein 5	Mus musculus	43-47
32698024-11	2020	Furthermore, the increase in ALP activity, LRP5 and phospho-Akt/Akt expression by 8PG and genistein were abolished by co-treatment with LY294002 (10-5 M, a PI3K pathway inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	thymoma viral proto-oncogene 1	Mus musculus	60-63
32698024-11	2020	Furthermore, the increase in ALP activity, LRP5 and phospho-Akt/Akt expression by 8PG and genistein were abolished by co-treatment with LY294002 (10-5 M, a PI3K pathway inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	thymoma viral proto-oncogene 1	Mus musculus	64-67
32627147-6	2020	PM exposure promoted P. aeruginosa invasion into BEAS-2B cells through ROS-mediated PI3K pathway which enhanced the expression of PAFR, which could be alleviated by treatment with NAC, LY294002, and BAY 11-7082.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	platelet activating factor receptor	Homo sapiens	130-134
32622012-15	2020	The overexpression of miR-199a-3p obviously restrained the HG-stimulated PI3K/AKT signalling pathway and angiogenesis, which could be further inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	microRNA 199a-2	Homo sapiens	22-33
32622012-15	2020	The overexpression of miR-199a-3p obviously restrained the HG-stimulated PI3K/AKT signalling pathway and angiogenesis, which could be further inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	AKT serine/threonine kinase 1	Homo sapiens	78-81
32622012-16	2020	Moreover, LY294002 could slightly ameliorate the miR-199a-3p inhibitor-stimulated PI3K/AKT signalling pathway and angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	microRNA 199a-2	Homo sapiens	49-60
32622012-16	2020	Moreover, LY294002 could slightly ameliorate the miR-199a-3p inhibitor-stimulated PI3K/AKT signalling pathway and angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	87-90
32687921-10	2020	Interestingly, the expression of PD-L1 was attenuated by both alpha-Cyperone and LY294002, while the supplement of IGF-1 rescued the low expression of PD-L1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	CD274 molecule	Homo sapiens	33-38
32945440-12	2020	However, the protective effects of ICAII were abolished by an inhibitor (LY294002) of the PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Rattus norvegicus	95-98
32945450-6	2020	Additionally, fluoxetine could inhibit the phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) signaling pathway, whereas LY294002, a specific inhibitor of PI3K, suppressed the function of PI3K-AKT signaling and suppressed the expression levels of glucose metabolism-associated proteins, including GSK-3beta, G6PC, PEPCK and FOXO1 in BRL-3A cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	AKT serine/threonine kinase 1	Rattus norvegicus	200-203
32945450-6	2020	Additionally, fluoxetine could inhibit the phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) signaling pathway, whereas LY294002, a specific inhibitor of PI3K, suppressed the function of PI3K-AKT signaling and suppressed the expression levels of glucose metabolism-associated proteins, including GSK-3beta, G6PC, PEPCK and FOXO1 in BRL-3A cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	glycogen synthase kinase 3 alpha	Rattus norvegicus	304-313
32945450-6	2020	Additionally, fluoxetine could inhibit the phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) signaling pathway, whereas LY294002, a specific inhibitor of PI3K, suppressed the function of PI3K-AKT signaling and suppressed the expression levels of glucose metabolism-associated proteins, including GSK-3beta, G6PC, PEPCK and FOXO1 in BRL-3A cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	315-319
32945450-6	2020	Additionally, fluoxetine could inhibit the phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) signaling pathway, whereas LY294002, a specific inhibitor of PI3K, suppressed the function of PI3K-AKT signaling and suppressed the expression levels of glucose metabolism-associated proteins, including GSK-3beta, G6PC, PEPCK and FOXO1 in BRL-3A cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	321-326
32945450-6	2020	Additionally, fluoxetine could inhibit the phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) signaling pathway, whereas LY294002, a specific inhibitor of PI3K, suppressed the function of PI3K-AKT signaling and suppressed the expression levels of glucose metabolism-associated proteins, including GSK-3beta, G6PC, PEPCK and FOXO1 in BRL-3A cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	forkhead box O1	Rattus norvegicus	331-336
32725369-8	2020	The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway was blocked by LY294002 and related protein levels were detected via western blot.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	thymoma viral proto-oncogene 1	Mus musculus	55-58
33305726-5	2020	LY294002, a PI3K inhibitor, is used to inhibit the activity of the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	72-75
32943002-7	2020	Furthermore, neuronal apoptosis induced by IHG was aggravated by the TrkA inhibitor K252a or the PI3K/AKT inhibitor LY294002, but this effect was alleviated by the p75NTR inhibitor TAT-pep5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
32934199-4	2020	This therapeutic effect was inhibited when the recipients were given LY294002, a selective inhibitor of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway or anti-EPO receptor (EPOR) antibody, in addition to CEPO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
32934199-7	2020	These effects were abolished by LY294002 or anti-EPOR antibody, suggesting that CEPO regulates immune responses and promotes kidney allograft survival by activating the PI3K/AKT signaling pathway in an EPOR-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	174-177
32934199-7	2020	These effects were abolished by LY294002 or anti-EPOR antibody, suggesting that CEPO regulates immune responses and promotes kidney allograft survival by activating the PI3K/AKT signaling pathway in an EPOR-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	erythropoietin receptor	Rattus norvegicus	202-206
32804027-9	2020	Pretreatment with 25 microM LY294002, a PI3K-specific inhibitor, further enhanced the si-TGF-beta-induced suppression of osteosarcoma progression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	transforming growth factor alpha	Homo sapiens	89-97
32450402-6	2020	Specific inhibitors of PI3K (LY294002) and mTOR (Rapamycin) and siRNA of Nrf2 were employed to verify that upregulation of Nrf2 correlated with activating the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
32900356-9	2021	LY294002 and rapamycin inhibited PI3K/Akt/mTOR and AQP1 expression (P<0.01), prevented the change of AQP1 location in SRA01/04 plasma membrane (P<0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	38-41
32900356-9	2021	LY294002 and rapamycin inhibited PI3K/Akt/mTOR and AQP1 expression (P<0.01), prevented the change of AQP1 location in SRA01/04 plasma membrane (P<0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	42-46
32900356-9	2021	LY294002 and rapamycin inhibited PI3K/Akt/mTOR and AQP1 expression (P<0.01), prevented the change of AQP1 location in SRA01/04 plasma membrane (P<0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	aquaporin 1 (Colton blood group)	Homo sapiens	51-55
32900356-9	2021	LY294002 and rapamycin inhibited PI3K/Akt/mTOR and AQP1 expression (P<0.01), prevented the change of AQP1 location in SRA01/04 plasma membrane (P<0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	aquaporin 1 (Colton blood group)	Homo sapiens	101-105
32885795-11	2020	The specific PI3K/Akt inhibitor LY294002, however, reversed these effects of ICA on UA-treated Min6 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	thymoma viral proto-oncogene 1	Mus musculus	18-21
32755041-8	2020	All the changes were counteracted to some extent by Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
33071721-17	2020	Treatment with LY294002 also increased the NLRP3 expression level, while the administration of LXA4 elicited the opposite effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	NLR family, pyrin domain containing 3	Rattus norvegicus	43-48
32982299-10	2020	OLR1 inhibition and LY294002 treatment significantly weakened the effects HSPA12B on activating the PI3K/Akt/mTOR signaling and M2 marker expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	heat shock protein 12B	Mus musculus	74-81
32982299-10	2020	OLR1 inhibition and LY294002 treatment significantly weakened the effects HSPA12B on activating the PI3K/Akt/mTOR signaling and M2 marker expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	thymoma viral proto-oncogene 1	Mus musculus	105-108
32982299-10	2020	OLR1 inhibition and LY294002 treatment significantly weakened the effects HSPA12B on activating the PI3K/Akt/mTOR signaling and M2 marker expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mechanistic target of rapamycin kinase	Mus musculus	109-113
32964954-6	2020	LY294002 was also used to inhibit the activity of PI3K/Akt signaling pathway to verify the mechanism of Tra2beta to protect chondrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	55-58
32964954-6	2020	LY294002 was also used to inhibit the activity of PI3K/Akt signaling pathway to verify the mechanism of Tra2beta to protect chondrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transformer 2 alpha homolog	Homo sapiens	104-112
32964954-10	2020	However, LY294002 attenuated the protective effect of Tra2beta on chondrocytes by inhibiting the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	transformer 2 alpha homolog	Homo sapiens	54-62
32964954-10	2020	However, LY294002 attenuated the protective effect of Tra2beta on chondrocytes by inhibiting the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	102-105
32803867-9	2020	PD98059 (an ERK1/2 inhibitor) and LY294002 (an AKT inhibitor) both inhibited BDNF-induced migration and integrin beta1 expression while integrin beta1 blocking antibody only suppressed cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	thymoma viral proto-oncogene 1	Mus musculus	47-50
32534061-5	2020	To address these issues, we establish a stabilized fracture model in mice and show that PI3K inhibitor LY294002 substantially inhibits the bone healing process, suggesting that PI3K/AKT promotes fracture repair.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	thymoma viral proto-oncogene 1	Mus musculus	182-185
32926102-7	2020	The PI3K inhibitor, LY294002, was used to elucidate the PI3K/Akt/mTOR signaling pathway in rCSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	61-64
32926102-7	2020	The PI3K inhibitor, LY294002, was used to elucidate the PI3K/Akt/mTOR signaling pathway in rCSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mechanistic target of rapamycin kinase	Homo sapiens	65-69
33164477-8	2020	However, LY294002, an inhibitor of the PI3K/Akt signaling pathway, alleviated the protective effect of FGF-2 on lung tissue.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	44-47
33164477-8	2020	However, LY294002, an inhibitor of the PI3K/Akt signaling pathway, alleviated the protective effect of FGF-2 on lung tissue.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	fibroblast growth factor 2	Homo sapiens	103-108
32803867-9	2020	PD98059 (an ERK1/2 inhibitor) and LY294002 (an AKT inhibitor) both inhibited BDNF-induced migration and integrin beta1 expression while integrin beta1 blocking antibody only suppressed cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	brain derived neurotrophic factor	Mus musculus	77-81
32803867-9	2020	PD98059 (an ERK1/2 inhibitor) and LY294002 (an AKT inhibitor) both inhibited BDNF-induced migration and integrin beta1 expression while integrin beta1 blocking antibody only suppressed cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	integrin beta 1 (fibronectin receptor beta)	Mus musculus	104-118
32272509-11	2020	Inhibition of protein kinase B (AKT) phosphorylation after irradiation by LY294002 reversed the dexamethasone-induced decrease of autophagy and cell death in U373 cells but provoked no effect on both autophagy and cell survival in LN229 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	protein tyrosine kinase 2 beta	Homo sapiens	14-30
32272509-11	2020	Inhibition of protein kinase B (AKT) phosphorylation after irradiation by LY294002 reversed the dexamethasone-induced decrease of autophagy and cell death in U373 cells but provoked no effect on both autophagy and cell survival in LN229 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	32-35
32929367-11	2020	Cadherin-11 was down-regulated by siRNA or up-regulated with a plasmid, with or without inflammatory factor stimulation, and PI3K/Akt was inhibited with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	cadherin 11	Homo sapiens	0-11
32546661-6	2020	We selected Wortmannin, LY294002 and AZD8055 for our studies, and showed that they blocked basal and glucocorticoid-induced REDD1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	DNA damage inducible transcript 4	Homo sapiens	124-129
32546661-10	2020	We found that co-administration of LY294002 or Rapamycin with Dexamethasone protected skin against Dexamethasone-induced atrophy, and normalized RANKL/OPG ratio indicating a reduction of Dexamethasone-induced osteoporosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	TNF superfamily member 11	Homo sapiens	145-150
32546661-10	2020	We found that co-administration of LY294002 or Rapamycin with Dexamethasone protected skin against Dexamethasone-induced atrophy, and normalized RANKL/OPG ratio indicating a reduction of Dexamethasone-induced osteoporosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	basic transcription factor 3 pseudogene 11	Homo sapiens	151-154
32825931-7	2020	However, MMP2 upregulation induced by Rab11a can be inhibited by the PI3K/AKT pathway inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	matrix metallopeptidase 2	Homo sapiens	9-13
32825931-7	2020	However, MMP2 upregulation induced by Rab11a can be inhibited by the PI3K/AKT pathway inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	RAB11A, member RAS oncogene family	Mus musculus	38-44
32825931-7	2020	However, MMP2 upregulation induced by Rab11a can be inhibited by the PI3K/AKT pathway inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	74-77
33006859-6	2020	After applying LY294002, the protein expression of AKT and p-AKT was down-regulated, mRNA and protein expression levels of RUNX2 and OPN were reduced and calcium salt deposition was reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	RAC-alpha serine/threonine-protein kinase	Ovis aries	51-54
33006859-6	2020	After applying LY294002, the protein expression of AKT and p-AKT was down-regulated, mRNA and protein expression levels of RUNX2 and OPN were reduced and calcium salt deposition was reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	RAC-alpha serine/threonine-protein kinase	Ovis aries	61-64
33006859-6	2020	After applying LY294002, the protein expression of AKT and p-AKT was down-regulated, mRNA and protein expression levels of RUNX2 and OPN were reduced and calcium salt deposition was reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	runt-related transcription factor 2	Ovis aries	123-128
33006859-6	2020	After applying LY294002, the protein expression of AKT and p-AKT was down-regulated, mRNA and protein expression levels of RUNX2 and OPN were reduced and calcium salt deposition was reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	osteopontin	Ovis aries	133-136
32584135-9	2020	Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	thymoma viral proto-oncogene 1	Mus musculus	38-41
32584135-9	2020	Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	BCL2 binding component 3	Mus musculus	93-97
32584135-9	2020	Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	follicle stimulating hormone beta	Mus musculus	106-109
32584135-9	2020	Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	follicle stimulating hormone beta	Mus musculus	135-138
32584135-9	2020	Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	BCL2 binding component 3	Mus musculus	165-169
32584135-9	2020	Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	thymoma viral proto-oncogene 1	Mus musculus	198-201
32922037-8	2020	However, PI3K inhibitor LY294002 reversed CPA4 overexpression-stimulated EMT in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	carboxypeptidase A4	Homo sapiens	42-46
32922037-12	2020	However, LY294002 reversed CPA4 overexpression-stimulated cell proliferation and drug resistance in vitro in Bcl2/Bax and caspase3-dependent apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	carboxypeptidase A4	Homo sapiens	27-31
32922037-12	2020	However, LY294002 reversed CPA4 overexpression-stimulated cell proliferation and drug resistance in vitro in Bcl2/Bax and caspase3-dependent apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	BCL2 apoptosis regulator	Homo sapiens	109-113
32922037-12	2020	However, LY294002 reversed CPA4 overexpression-stimulated cell proliferation and drug resistance in vitro in Bcl2/Bax and caspase3-dependent apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	BCL2 associated X, apoptosis regulator	Homo sapiens	114-117
32922037-12	2020	However, LY294002 reversed CPA4 overexpression-stimulated cell proliferation and drug resistance in vitro in Bcl2/Bax and caspase3-dependent apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	caspase 3	Homo sapiens	122-130
32846937-6	2020	However, the Akt specific inhibitor Ly294002 could significantly reduce the virus titer in MDBK cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Bos taurus	13-16
32973444-9	2020	In contrast, the effect of LY294002 (a highly selective Akt inhibitor) on proliferation and differentiation was similar to that of VU.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	56-59
32209778-9	2020	However, an Akt inhibitor LY294002, which was injected at 15 nmol/kg via the tail vein, attenuated the protective effects of IL-4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	thymoma viral proto-oncogene 1	Mus musculus	12-15
32209778-9	2020	However, an Akt inhibitor LY294002, which was injected at 15 nmol/kg via the tail vein, attenuated the protective effects of IL-4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	interleukin 4	Mus musculus	125-129
33006859-3	2020	Western blot was used before and after applying the PI3K/Akt signalling pathway inhibitor LY294002 to detect protein expression levels of AKT and p-AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	RAC-alpha serine/threonine-protein kinase	Ovis aries	57-60
33006859-3	2020	Western blot was used before and after applying the PI3K/Akt signalling pathway inhibitor LY294002 to detect protein expression levels of AKT and p-AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	RAC-alpha serine/threonine-protein kinase	Ovis aries	138-141
33006859-3	2020	Western blot was used before and after applying the PI3K/Akt signalling pathway inhibitor LY294002 to detect protein expression levels of AKT and p-AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	RAC-alpha serine/threonine-protein kinase	Ovis aries	148-151
32929367-11	2020	Cadherin-11 was down-regulated by siRNA or up-regulated with a plasmid, with or without inflammatory factor stimulation, and PI3K/Akt was inhibited with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	AKT serine/threonine kinase 1	Homo sapiens	130-133
32762281-8	2022	Treatment of PI3K inhibitor LY294002 significantly increased the apoptosis rate of HBMVECs, and this effect was significantly reversed by transfection of miR-17-5p mimics, while further dramatically enhanced by overexpression of PTEN.Conclusion: MiR-17-5p could amelioratecerebral I/R injury-induced cell apoptosis by directly targeting PTEN and regulation of PI3K/AKT/mTOR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	microRNA 17	Homo sapiens	154-163
32811251-4	2021	We performed concentration response curves of LY294002, a pan-PI3 kinase inhibitor, on platelet aggregation and Akt phosphorylation, in washed human and mouse platelets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	112-115
32811251-5	2021	At concentrations as low as 3.12 microM, LY294002 abolished Akt phosphorylation induced by 2MeSADP and SFLLRN, but not by AYPGKF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	thymoma viral proto-oncogene 1	Mus musculus	60-63
32811251-6	2021	It required much higher concentrations of LY294002 (12.5-25 microM) to abolish AYPGKF-induced Akt phosphorylation, both in wild type and P2Y12 null mouse platelets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	thymoma viral proto-oncogene 1	Mus musculus	94-97
32811251-6	2021	It required much higher concentrations of LY294002 (12.5-25 microM) to abolish AYPGKF-induced Akt phosphorylation, both in wild type and P2Y12 null mouse platelets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	purinergic receptor P2Y, G-protein coupled 12	Mus musculus	137-142
32811251-7	2021	We propose that 3.12 microM LY294002 is sufficient to inhibit PI3 kinase isoforms in platelets and higher concentrations might inhibit other pathways regulating Akt phosphorylation by AYPGKF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	thymoma viral proto-oncogene 1	Mus musculus	161-164
32762281-8	2022	Treatment of PI3K inhibitor LY294002 significantly increased the apoptosis rate of HBMVECs, and this effect was significantly reversed by transfection of miR-17-5p mimics, while further dramatically enhanced by overexpression of PTEN.Conclusion: MiR-17-5p could amelioratecerebral I/R injury-induced cell apoptosis by directly targeting PTEN and regulation of PI3K/AKT/mTOR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	phosphatase and tensin homolog	Homo sapiens	229-233
32762281-8	2022	Treatment of PI3K inhibitor LY294002 significantly increased the apoptosis rate of HBMVECs, and this effect was significantly reversed by transfection of miR-17-5p mimics, while further dramatically enhanced by overexpression of PTEN.Conclusion: MiR-17-5p could amelioratecerebral I/R injury-induced cell apoptosis by directly targeting PTEN and regulation of PI3K/AKT/mTOR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	microRNA 17	Homo sapiens	246-255
32762281-8	2022	Treatment of PI3K inhibitor LY294002 significantly increased the apoptosis rate of HBMVECs, and this effect was significantly reversed by transfection of miR-17-5p mimics, while further dramatically enhanced by overexpression of PTEN.Conclusion: MiR-17-5p could amelioratecerebral I/R injury-induced cell apoptosis by directly targeting PTEN and regulation of PI3K/AKT/mTOR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	phosphatase and tensin homolog	Homo sapiens	337-341
32762281-8	2022	Treatment of PI3K inhibitor LY294002 significantly increased the apoptosis rate of HBMVECs, and this effect was significantly reversed by transfection of miR-17-5p mimics, while further dramatically enhanced by overexpression of PTEN.Conclusion: MiR-17-5p could amelioratecerebral I/R injury-induced cell apoptosis by directly targeting PTEN and regulation of PI3K/AKT/mTOR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	365-368
32762281-8	2022	Treatment of PI3K inhibitor LY294002 significantly increased the apoptosis rate of HBMVECs, and this effect was significantly reversed by transfection of miR-17-5p mimics, while further dramatically enhanced by overexpression of PTEN.Conclusion: MiR-17-5p could amelioratecerebral I/R injury-induced cell apoptosis by directly targeting PTEN and regulation of PI3K/AKT/mTOR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	mechanistic target of rapamycin kinase	Homo sapiens	369-373
32770981-12	2020	Hence, the PI3K/AKT inhibitor LY294002 was used to determine the relationship between USP18 and AKT in cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	ubiquitin specific peptidase 18	Homo sapiens	86-91
32869594-8	2020	Compared with the LY294002+EA group, the number of neuronal apoptosis in the left cortex was decreased in the EA group (P<0.01), and the expression of Bax, Caspase-9 and Cyt-C was decreased (P<0.01, P<0.05), and the expression of p-Akt/Akt and Bcl-2 was increased (P<0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	caspase 9	Rattus norvegicus	156-165
32869594-8	2020	Compared with the LY294002+EA group, the number of neuronal apoptosis in the left cortex was decreased in the EA group (P<0.01), and the expression of Bax, Caspase-9 and Cyt-C was decreased (P<0.01, P<0.05), and the expression of p-Akt/Akt and Bcl-2 was increased (P<0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	232-235
32869594-8	2020	Compared with the LY294002+EA group, the number of neuronal apoptosis in the left cortex was decreased in the EA group (P<0.01), and the expression of Bax, Caspase-9 and Cyt-C was decreased (P<0.01, P<0.05), and the expression of p-Akt/Akt and Bcl-2 was increased (P<0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	236-239
32869594-8	2020	Compared with the LY294002+EA group, the number of neuronal apoptosis in the left cortex was decreased in the EA group (P<0.01), and the expression of Bax, Caspase-9 and Cyt-C was decreased (P<0.01, P<0.05), and the expression of p-Akt/Akt and Bcl-2 was increased (P<0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	BCL2, apoptosis regulator	Rattus norvegicus	244-249
32504794-7	2020	The neuroprotective effects were abrogated by treatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	65-94
32770981-13	2020	Importantly, LY294002 significantly abolished the effects of USP18 overexpression in cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	ubiquitin specific peptidase 18	Homo sapiens	61-66
32770981-12	2020	Hence, the PI3K/AKT inhibitor LY294002 was used to determine the relationship between USP18 and AKT in cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	96-99
31884678-10	2020	PM exposure led to the phosphorylation of ERK, JNK, and PI3K signaling pathways in a time-dependent manner, while blockade of PI3K with the specific molecular inhibitor LY294002 partially reversed the dysregulation of COX-2/PGE2 and Filaggrin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	filaggrin	Homo sapiens	233-242
32638014-9	2020	In addition, the inhibitory effects of ISL on TGF-beta1-induced fibrogenic features in MRC-5 cells were enhanced by pretreatment with autophagy activator Rapmycin and PI3K/AKT inhibitor LY294002 and reversed by autophagy inhibitor 3-methyladenine and PI3K/AKT activator IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	transforming growth factor beta 1	Homo sapiens	46-55
32638014-9	2020	In addition, the inhibitory effects of ISL on TGF-beta1-induced fibrogenic features in MRC-5 cells were enhanced by pretreatment with autophagy activator Rapmycin and PI3K/AKT inhibitor LY294002 and reversed by autophagy inhibitor 3-methyladenine and PI3K/AKT activator IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	AKT serine/threonine kinase 1	Homo sapiens	172-175
31884678-10	2020	PM exposure led to the phosphorylation of ERK, JNK, and PI3K signaling pathways in a time-dependent manner, while blockade of PI3K with the specific molecular inhibitor LY294002 partially reversed the dysregulation of COX-2/PGE2 and Filaggrin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	mitogen-activated protein kinase 8	Homo sapiens	47-50
32765666-8	2020	PI3K inhibitor (LY294002) was also used to treat p53-/- mice, and the results demonstrated that LY294002 revert the change of PLTs in these mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	transformation related protein 53	Mus musculus	49-52
31884678-10	2020	PM exposure led to the phosphorylation of ERK, JNK, and PI3K signaling pathways in a time-dependent manner, while blockade of PI3K with the specific molecular inhibitor LY294002 partially reversed the dysregulation of COX-2/PGE2 and Filaggrin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	218-223
32742376-5	2020	In HCT116 cells expressing wild-type (wt) TP53, SIRT inhibitors were found to act antagonistically with multiple chemotherapeutic agents (cisplatin, 5-fluorouracil, oxaliplatin, gefitinib, LY294002 and metformin), and decreased the anti-tumor effects of these agents.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	tumor protein p53	Homo sapiens	42-46
31280345-11	2020	delta-TT prevention of oxidative damage was completely removed by combined treatment with the specific inhibitors of PI3K/AKT (LY294002) and Nrf2 (ML385).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	thymoma viral proto-oncogene 1	Mus musculus	122-125
32531188-9	2020	Moreover, pretreatment with LY294002 could eliminate the effects of AST preconditioning on the decrease of HMGB1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	high mobility group box 1	Mus musculus	107-112
32765666-8	2020	PI3K inhibitor (LY294002) was also used to treat p53-/- mice, and the results demonstrated that LY294002 revert the change of PLTs in these mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	transformation related protein 53	Mus musculus	49-52
32275808-8	2020	Pretreatment with a PI3K/AKT inhibitor, LY294002, mimicked the ABA-mediated effects on cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	25-28
32686770-4	2020	This leptin action was reduced by Janus kinase inhibitor (AG490) or PI3-kinase inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	leptin	Rattus norvegicus	5-11
32755998-5	2020	The use of PI3K inhibitors such as Wortmannin (100 nM) and LY294002 (50 microM) completely prevented the FGF21-dependent glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	fibroblast growth factor 21	Mus musculus	105-110
32626962-7	2020	LY294002, a selective PI3K inhibitor, inhibited the PI3K/AKT/HIF-1alpha signaling pathway and further attenuated the protective effect of troxerutin against OGD/R-induced H9C2 cell damage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
32626962-7	2020	LY294002, a selective PI3K inhibitor, inhibited the PI3K/AKT/HIF-1alpha signaling pathway and further attenuated the protective effect of troxerutin against OGD/R-induced H9C2 cell damage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	61-71
32863960-9	2020	The PI3K/Akt inhibitor LY294002 was utilized to identify the effects of the PI3K-Akt/Nrf2 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	thymoma viral proto-oncogene 1	Mus musculus	9-12
32863960-9	2020	The PI3K/Akt inhibitor LY294002 was utilized to identify the effects of the PI3K-Akt/Nrf2 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	thymoma viral proto-oncogene 1	Mus musculus	81-84
32863960-9	2020	The PI3K/Akt inhibitor LY294002 was utilized to identify the effects of the PI3K-Akt/Nrf2 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
32385839-0	2020	Pyrroloquinoline Quinine and LY294002 Changed Cell Cycle and Apoptosis by Regulating PI3K-AKT-GSK3beta Pathway in SH-SY5Y Cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	90-93
32385839-0	2020	Pyrroloquinoline Quinine and LY294002 Changed Cell Cycle and Apoptosis by Regulating PI3K-AKT-GSK3beta Pathway in SH-SY5Y Cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	glycogen synthase kinase 3 alpha	Homo sapiens	94-102
32385839-11	2020	Mn can cause apoptosis and necrosis, varying cell cycle of SH-SY5Y cells, which could be changed by PQQ and LY294002 by regulating PI3K-AKT-GSK3beta pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Homo sapiens	136-139
32385839-11	2020	Mn can cause apoptosis and necrosis, varying cell cycle of SH-SY5Y cells, which could be changed by PQQ and LY294002 by regulating PI3K-AKT-GSK3beta pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	glycogen synthase kinase 3 alpha	Homo sapiens	140-148
32893562-7	2020	The above effects could be weakened by miR-198 antagonist and PI3 K-Akt signal pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Rattus norvegicus	68-71
32774685-8	2020	Pretreatment with the inhibitor of PI3K/Akt signaling (LY294002) completely blocked these EE-TT-upregulated mRNA expressions and abolished the improvement of cell viability in H2O2-treated ARPE-19 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	40-43
32722075-8	2020	In addition, LY and TAM combination induced the apoptotic genes Caspase-3, Caspase-7, and p53, as well as p21 as cell cycle promotor, and significantly downregulated the anti-apoptotic genes Bcl-2 and survivin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-15	caspase 3	Homo sapiens	64-73
32722075-8	2020	In addition, LY and TAM combination induced the apoptotic genes Caspase-3, Caspase-7, and p53, as well as p21 as cell cycle promotor, and significantly downregulated the anti-apoptotic genes Bcl-2 and survivin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-15	caspase 7	Homo sapiens	75-84
32722075-8	2020	In addition, LY and TAM combination induced the apoptotic genes Caspase-3, Caspase-7, and p53, as well as p21 as cell cycle promotor, and significantly downregulated the anti-apoptotic genes Bcl-2 and survivin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-15	tumor protein p53	Homo sapiens	90-93
32722075-8	2020	In addition, LY and TAM combination induced the apoptotic genes Caspase-3, Caspase-7, and p53, as well as p21 as cell cycle promotor, and significantly downregulated the anti-apoptotic genes Bcl-2 and survivin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-15	H3 histone pseudogene 16	Homo sapiens	106-109
32722075-8	2020	In addition, LY and TAM combination induced the apoptotic genes Caspase-3, Caspase-7, and p53, as well as p21 as cell cycle promotor, and significantly downregulated the anti-apoptotic genes Bcl-2 and survivin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-15	BCL2 apoptosis regulator	Homo sapiens	191-196
32722075-11	2020	The results suggested that the synergistic cytotoxic effect of LY and TAM is achieved by the induction of apoptosis and cell cycle arrest through cyclin D1, pAKT, caspases, and Bcl-2 signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-65	cyclin D1	Homo sapiens	146-155
32722075-11	2020	The results suggested that the synergistic cytotoxic effect of LY and TAM is achieved by the induction of apoptosis and cell cycle arrest through cyclin D1, pAKT, caspases, and Bcl-2 signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-65	BCL2 apoptosis regulator	Homo sapiens	177-182
32774743-8	2020	However, these beneficial effects can be inhibited by PI3K/AKT inhibitor LY294002 and MEK/ERK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Homo sapiens	59-62
32407984-8	2020	The beneficial effects of nicorandil on HCAECs could be inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the nitric oxide synthase (NOS) inhibitor L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	73-102
32456793-5	2020	Importantly, LM2 cells simultaneously treated with U0126 and PI3K inhibitor LY294002 exhibited reduced expression of SNAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	snail family zinc finger 1	Mus musculus	117-122
32765028-12	2020	When the PI3K/AKT signaling pathway was inhibited by LY294002 (AKT inhibitor), the protective effect of EGCG on HG-treated HUVECs was weakened.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	14-17
32765028-12	2020	When the PI3K/AKT signaling pathway was inhibited by LY294002 (AKT inhibitor), the protective effect of EGCG on HG-treated HUVECs was weakened.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	63-66
31504249-10	2020	Importantly, pharmacological inhibition of PI3K/AKT by LY294002 diminished EF-induced activation of AKT and restored the cytotoxicity of osimertinib suppressed by EFs, which proved that AKT activation was essential for EFs to attenuate the efficacy of osimertinib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	48-51
31504249-10	2020	Importantly, pharmacological inhibition of PI3K/AKT by LY294002 diminished EF-induced activation of AKT and restored the cytotoxicity of osimertinib suppressed by EFs, which proved that AKT activation was essential for EFs to attenuate the efficacy of osimertinib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	100-103
31504249-10	2020	Importantly, pharmacological inhibition of PI3K/AKT by LY294002 diminished EF-induced activation of AKT and restored the cytotoxicity of osimertinib suppressed by EFs, which proved that AKT activation was essential for EFs to attenuate the efficacy of osimertinib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	100-103
32622431-11	2020	Moreover, PI3K inhibitor (LY294002) significantly decreased A549 cell viability rate induced by LS, abrogated the activation of p-PI3K/PI3K and p-AKT/AKT in the presence of LS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	146-149
32622431-11	2020	Moreover, PI3K inhibitor (LY294002) significantly decreased A549 cell viability rate induced by LS, abrogated the activation of p-PI3K/PI3K and p-AKT/AKT in the presence of LS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	150-153
32196840-6	2020	Most important, all the changes induced by TRIM25 overexpression in Huh7 were reversed with additional treatment of LY294002 (an AKT pathway inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	tripartite motif containing 25	Homo sapiens	43-49
32092300-6	2020	In addition, the neuroprotective effects of MN-06 could be abolished by LY294002, the specific phosphatidylinositol 3-kinase (PI3-K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	95-124
32196840-6	2020	Most important, all the changes induced by TRIM25 overexpression in Huh7 were reversed with additional treatment of LY294002 (an AKT pathway inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	MIR7-3 host gene	Homo sapiens	68-72
32196840-6	2020	Most important, all the changes induced by TRIM25 overexpression in Huh7 were reversed with additional treatment of LY294002 (an AKT pathway inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	129-132
32077518-9	2020	Treatment with LY294002, an inhibitor of Akt, reversed the induction effects of CTRP6 overexpression on ROS production, inflammation and ECM accumulation in MCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	41-44
32077518-9	2020	Treatment with LY294002, an inhibitor of Akt, reversed the induction effects of CTRP6 overexpression on ROS production, inflammation and ECM accumulation in MCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	C1q and TNF related 6	Homo sapiens	80-85
32548942-7	2020	We used phosphatidylinositol-3-kinase inhibitor Ly294002 to block the activation of the AKT/GSK-3beta pathway and found that it partially reversed the protection by Rg1 and decreased Nrf2 pathway activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Rattus norvegicus	88-91
32463592-7	2020	Cystic fibrosis transmembrane conductance regulator activates Akt/Bcl2 pathway, and suppression of PI3K/Akt pathway abolishes CFTR overexpression-induced up-regulation of Bcl2 (MK-2206 and LY294002) and cell viability (MK-2206).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	AKT serine/threonine kinase 1	Homo sapiens	104-107
32463592-7	2020	Cystic fibrosis transmembrane conductance regulator activates Akt/Bcl2 pathway, and suppression of PI3K/Akt pathway abolishes CFTR overexpression-induced up-regulation of Bcl2 (MK-2206 and LY294002) and cell viability (MK-2206).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	CF transmembrane conductance regulator	Homo sapiens	126-130
32144792-6	2020	LY294002, a PI3K inhibitor, could inhibit the phosphorylation of Akt and reduce the expression of TLR4, thus reduce the foam cell source and lipid volume in the unstable plaque tissue.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	65-68
32144792-6	2020	LY294002, a PI3K inhibitor, could inhibit the phosphorylation of Akt and reduce the expression of TLR4, thus reduce the foam cell source and lipid volume in the unstable plaque tissue.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	toll-like receptor 4	Mus musculus	98-102
31886572-10	2020	The protective effects of CCK-8 were partly abolished by Devazepide or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	cholecystokinin	Rattus norvegicus	26-29
32463592-7	2020	Cystic fibrosis transmembrane conductance regulator activates Akt/Bcl2 pathway, and suppression of PI3K/Akt pathway abolishes CFTR overexpression-induced up-regulation of Bcl2 (MK-2206 and LY294002) and cell viability (MK-2206).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	BCL2 apoptosis regulator	Homo sapiens	171-175
32548942-7	2020	We used phosphatidylinositol-3-kinase inhibitor Ly294002 to block the activation of the AKT/GSK-3beta pathway and found that it partially reversed the protection by Rg1 and decreased Nrf2 pathway activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	glycogen synthase kinase 3 alpha	Rattus norvegicus	92-101
32548942-7	2020	We used phosphatidylinositol-3-kinase inhibitor Ly294002 to block the activation of the AKT/GSK-3beta pathway and found that it partially reversed the protection by Rg1 and decreased Nrf2 pathway activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	183-187
32742458-14	2020	Importantly, mechanistic investigations suggested that dnMST4 significantly elevated the phosphorylation levels of key members of PI3K/AKT pathway, and the selective PI3K inhibitor LY294002 can reverse the proliferation-promoting effect of dnMST4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	AKT serine/threonine kinase 1	Homo sapiens	135-138
32386481-9	2020	More important, preconditioning with PI3K/AKT inhibitor LY294002 or mTOR inhibitor rapamycin both aggravated KLK10 knockdown-suppressed cancer cell growth and glucose metabolism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	42-45
32386481-9	2020	More important, preconditioning with PI3K/AKT inhibitor LY294002 or mTOR inhibitor rapamycin both aggravated KLK10 knockdown-suppressed cancer cell growth and glucose metabolism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	kallikrein related peptidase 10	Homo sapiens	109-114
32691555-4	2020	With LY294002 pretreatment, the mitochondrial transmembrane potential level and the expressions of p-PI3K, p-AKt and Bcl-2 were decreased, the expression of Bax and the apoptosis rate were increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	AKT serine/threonine kinase 1	Homo sapiens	109-112
32691555-4	2020	With LY294002 pretreatment, the mitochondrial transmembrane potential level and the expressions of p-PI3K, p-AKt and Bcl-2 were decreased, the expression of Bax and the apoptosis rate were increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	BCL2 apoptosis regulator	Homo sapiens	117-122
32691555-4	2020	With LY294002 pretreatment, the mitochondrial transmembrane potential level and the expressions of p-PI3K, p-AKt and Bcl-2 were decreased, the expression of Bax and the apoptosis rate were increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	BCL2 associated X, apoptosis regulator	Homo sapiens	157-160
32600449-10	2020	These effects were associated with increased levels of phosphorylated Akt and eNOS, which could be abolished by PI3K inhibitor (LY294002) or Ras inhibitor (NSC 23766).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	thymoma viral proto-oncogene 1	Mus musculus	70-73
32600449-10	2020	These effects were associated with increased levels of phosphorylated Akt and eNOS, which could be abolished by PI3K inhibitor (LY294002) or Ras inhibitor (NSC 23766).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	nitric oxide synthase 3, endothelial cell	Mus musculus	78-82
32377707-4	2020	In the present study, Abeta oligomer levels were assessed in astrocytic cell lysates after treatment with PNU282987 (a potent agonist of alpha7 nAChRs) or co-treatment with LY294002, a p-Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	amyloid beta precursor protein	Homo sapiens	22-27
32166572-7	2020	We also determined that the inhibitory effects of NDRG4 on cell apoptosis and Reactive oxygen species release were partially reversed by BDNF silencing, and by application of the PI3K specific inhibitor (LY294002) or ERK inhibitor (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	204-212	NDRG family member 4	Homo sapiens	50-55
32510127-8	2020	However, LY294002 did not completely inhibit AKT phosphorylation, and partially inhibited AMPK phosphorylation, whilst compound C only partially reduced AMPK phosphorylation, and also partially inhibited AKT phosphorylation, suggesting that AKT and AMPK interact to improve insulin resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	90-94
32591494-12	2020	Incubation with the PI3K inhibitor Ly294002 impaired the enhanced effect of Rab7 overexpression on proliferation, migration, and invasion abilities of GC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	RAB7B, member RAS oncogene family	Homo sapiens	76-80
32436939-10	2020	Mechanistically, we show that the action of PTX3 requires the activation of PI3K and Akt, and deactivation of PI3K by its inhibitor LY294002 weakens the PTX3-mediated induction of osteoblast signature genes, ALP, and matrix mineralization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	pentraxin related gene	Mus musculus	153-157
32655764-7	2020	Interestingly, we highlight that PI3K/AKT inhibitor (LY294002) markedly increased the expression of Nrf2 antioxidant pathway, PPARalpha, and downregulated SREBP-1c in FFA-stimulated HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	38-41
32630394-8	2020	Further, the use of the inhibitors PD98059 and LY294002 also showed that Erk1/2 and Akt signaling pathways were involved in the neuroprotection mediated by ESC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	mitogen-activated protein kinase 3	Homo sapiens	73-79
32630394-8	2020	Further, the use of the inhibitors PD98059 and LY294002 also showed that Erk1/2 and Akt signaling pathways were involved in the neuroprotection mediated by ESC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	84-87
32655764-7	2020	Interestingly, we highlight that PI3K/AKT inhibitor (LY294002) markedly increased the expression of Nrf2 antioxidant pathway, PPARalpha, and downregulated SREBP-1c in FFA-stimulated HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
32655764-7	2020	Interestingly, we highlight that PI3K/AKT inhibitor (LY294002) markedly increased the expression of Nrf2 antioxidant pathway, PPARalpha, and downregulated SREBP-1c in FFA-stimulated HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	peroxisome proliferator activated receptor alpha	Homo sapiens	126-135
32655764-7	2020	Interestingly, we highlight that PI3K/AKT inhibitor (LY294002) markedly increased the expression of Nrf2 antioxidant pathway, PPARalpha, and downregulated SREBP-1c in FFA-stimulated HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	sterol regulatory element binding transcription factor 1	Homo sapiens	155-163
32538764-6	2020	The HepG2 cells were also treated with PI3K/Akt signaling pathway inhibitor LY294002, and its effect on cell proliferation, migration, invasion, and apoptosis, and expressions of PIK3, Akt, and p-Akt proteins were determined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	44-47
32606946-5	2020	L740Y-P (activator of PI3K/AKT pathway) and LY294002 (inhibitor of PI3k/AKT pathway) were used to interfere with PI3k/Akt signaling pathway in osteosarcoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	72-75
32606946-5	2020	L740Y-P (activator of PI3K/AKT pathway) and LY294002 (inhibitor of PI3k/AKT pathway) were used to interfere with PI3k/Akt signaling pathway in osteosarcoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	118-121
32606946-12	2020	LY294002 intervention could reverse the promotion of Sh-TDRG1 on osteosarcoma cell proliferation, invasion, migration and EMT and the inhibition of cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	testis development related 1	Homo sapiens	56-61
32606928-12	2020	Compared with UO126 (a Mek1/2 inhibitor), LY294002 (a PI3K inhibitor) attenuated the AQP3-induced insensitivity to sorafenib observed in hypoxic cells transfected with Lv-AQP3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	aquaporin 3 (Gill blood group)	Homo sapiens	85-89
32606928-12	2020	Compared with UO126 (a Mek1/2 inhibitor), LY294002 (a PI3K inhibitor) attenuated the AQP3-induced insensitivity to sorafenib observed in hypoxic cells transfected with Lv-AQP3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	aquaporin 3 (Gill blood group)	Homo sapiens	171-175
32527040-9	2020	Specific inhibitors of Akt/GSK-3beta (LY294002) and MEK/ERK (PD98059) signaling prevented the inhibition of melanogenesis by NBI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	thymoma viral proto-oncogene 1	Mus musculus	23-26
32511663-7	2020	A more in-depth study demonstrated that LY294002 (a specific inhibitor of PI3K), abolished the selenium-mediated cytoprotective effect of MC3T3-E1 cells against LPS-induced injury and down-regulation of miR-155.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	microRNA 155	Mus musculus	203-210
32538764-11	2020	After treatment of HepG2 cells with PI3K/Akt signaling pathway inhibitor LY294002, the proliferative, migratory and invasive abilities of cells in the treatment group were significantly enhanced, while cell apoptosis was significantly reduced (p < 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Homo sapiens	41-44
32665986-10	2020	Pharmacological inhibition of PI3K/Akt by LY294002 abrogated E2-induced expression of PPARgamma (0.24 +-0.09-fold; n = 3; p vs. E2 = 0.0017).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	AKT serine/threonine kinase 1	Homo sapiens	35-38
32581555-9	2020	Upon inhibiting the PI3K/Akt pathway with LY294002 prior to cotreatment, we detected enhanced PARP cleavage compared to that in the cotreatment only group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	AKT serine/threonine kinase 1	Homo sapiens	25-28
32665986-10	2020	Pharmacological inhibition of PI3K/Akt by LY294002 abrogated E2-induced expression of PPARgamma (0.24 +-0.09-fold; n = 3; p vs. E2 = 0.0017).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	peroxisome proliferator activated receptor gamma	Homo sapiens	86-95
32495214-5	2020	Blocking autophagy with pharmacological inhibitors chloroquine (CQ) or LY294002 partly reduced T-DM1-induced apoptosis and Caspase-3/7 activation, suggesting that autophagy played an essential role in the cytotoxicity induced by T-DM1 in HER2-positive breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	immunoglobulin heavy diversity 1-7	Homo sapiens	97-100
32495214-5	2020	Blocking autophagy with pharmacological inhibitors chloroquine (CQ) or LY294002 partly reduced T-DM1-induced apoptosis and Caspase-3/7 activation, suggesting that autophagy played an essential role in the cytotoxicity induced by T-DM1 in HER2-positive breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	caspase 3	Homo sapiens	123-134
32495214-5	2020	Blocking autophagy with pharmacological inhibitors chloroquine (CQ) or LY294002 partly reduced T-DM1-induced apoptosis and Caspase-3/7 activation, suggesting that autophagy played an essential role in the cytotoxicity induced by T-DM1 in HER2-positive breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	immunoglobulin heavy diversity 1-7	Homo sapiens	231-234
32495214-5	2020	Blocking autophagy with pharmacological inhibitors chloroquine (CQ) or LY294002 partly reduced T-DM1-induced apoptosis and Caspase-3/7 activation, suggesting that autophagy played an essential role in the cytotoxicity induced by T-DM1 in HER2-positive breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	238-242
32581555-9	2020	Upon inhibiting the PI3K/Akt pathway with LY294002 prior to cotreatment, we detected enhanced PARP cleavage compared to that in the cotreatment only group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	poly(ADP-ribose) polymerase 1	Homo sapiens	94-98
31758290-7	2020	While TMZ treated cells did not show alteration in any of the Wnt ligands, PI3K inhibitor (LY294002) treatment repressed Akt activation and abolished the TMZ-mediated induction of Wnt/beta-catenin pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	AKT serine/threonine kinase 1	Homo sapiens	121-124
32581541-10	2020	LY294002 reversed the effects of lupeol on the expression of PI3K/Akt signaling pathway-related proteins and cleaved caspase-3 after I/R in rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	66-69
32581541-10	2020	LY294002 reversed the effects of lupeol on the expression of PI3K/Akt signaling pathway-related proteins and cleaved caspase-3 after I/R in rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Rattus norvegicus	117-126
32200003-8	2020	These protective effects of hypothermia on pyroptosis-related proteins and pro-inflammatory cytokines were partially reversed by the specific PI3K/Akt inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	AKT serine/threonine kinase 1	Homo sapiens	147-150
32175798-5	2020	Upon KDM2B overexpression in DU-145 cells, significantly enhanced migration was observed, which was abolished in cells pretreated by the specific phosphoinositide-3 kinase (PI3 K) inhibitor LY294002, implying involvement of FAK/PI3 K signaling in the migration process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	lysine demethylase 2B	Homo sapiens	5-10
32175798-5	2020	Upon KDM2B overexpression in DU-145 cells, significantly enhanced migration was observed, which was abolished in cells pretreated by the specific phosphoinositide-3 kinase (PI3 K) inhibitor LY294002, implying involvement of FAK/PI3 K signaling in the migration process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	146-171
32175798-5	2020	Upon KDM2B overexpression in DU-145 cells, significantly enhanced migration was observed, which was abolished in cells pretreated by the specific phosphoinositide-3 kinase (PI3 K) inhibitor LY294002, implying involvement of FAK/PI3 K signaling in the migration process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	protein tyrosine kinase 2	Homo sapiens	224-227
31758290-7	2020	While TMZ treated cells did not show alteration in any of the Wnt ligands, PI3K inhibitor (LY294002) treatment repressed Akt activation and abolished the TMZ-mediated induction of Wnt/beta-catenin pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	catenin beta 1	Homo sapiens	184-196
32087305-6	2020	Treatment with LY294002, a specific inhibitor of the PI3K pathway, could abrogate VEGF-increased angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	vascular endothelial growth factor A	Macaca mulatta	82-86
32325280-16	2020	Additionally, SC79 and LY294002 reversed the effects of CADM4 overexpression and CADM4 knockdown in vitro, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	cell adhesion molecule 4	Mus musculus	56-61
32222636-10	2020	The abolishment of the PI3K/AKT via a pharmacological inhibitor (LY294002) repressed anti-H/R capabilities of SH2B1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	28-31
32222636-10	2020	The abolishment of the PI3K/AKT via a pharmacological inhibitor (LY294002) repressed anti-H/R capabilities of SH2B1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	SH2B adaptor protein 1	Homo sapiens	110-115
32173422-4	2020	Furthermore, inhibition of PI3K-Akt pathway by pharmacological inhibitor, LY294002 enhanced the apoptotic cell death induced by alpha-santalol as determined by cell viability, cellular morphology, active caspase-3 activity and expression of cleaved PARP, cleaved caspase-3 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	32-35
32173422-4	2020	Furthermore, inhibition of PI3K-Akt pathway by pharmacological inhibitor, LY294002 enhanced the apoptotic cell death induced by alpha-santalol as determined by cell viability, cellular morphology, active caspase-3 activity and expression of cleaved PARP, cleaved caspase-3 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	caspase 3	Homo sapiens	204-213
32173422-4	2020	Furthermore, inhibition of PI3K-Akt pathway by pharmacological inhibitor, LY294002 enhanced the apoptotic cell death induced by alpha-santalol as determined by cell viability, cellular morphology, active caspase-3 activity and expression of cleaved PARP, cleaved caspase-3 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	collagen type XI alpha 2 chain	Homo sapiens	249-253
32173422-4	2020	Furthermore, inhibition of PI3K-Akt pathway by pharmacological inhibitor, LY294002 enhanced the apoptotic cell death induced by alpha-santalol as determined by cell viability, cellular morphology, active caspase-3 activity and expression of cleaved PARP, cleaved caspase-3 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	caspase 3	Homo sapiens	263-272
32325280-16	2020	Additionally, SC79 and LY294002 reversed the effects of CADM4 overexpression and CADM4 knockdown in vitro, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	cell adhesion molecule 4	Mus musculus	81-86
32347651-7	2020	LY294002 or Akt-siRNA inhibited the PI3K/Akt/FoxO3a pathway and promoted the Pristimerin-induced apoptosis, while Pristimerin effects were partially abolished in FoxO3a knockdown UM-1 cell cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	41-44
32347651-7	2020	LY294002 or Akt-siRNA inhibited the PI3K/Akt/FoxO3a pathway and promoted the Pristimerin-induced apoptosis, while Pristimerin effects were partially abolished in FoxO3a knockdown UM-1 cell cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	forkhead box O3	Homo sapiens	45-51
32347651-7	2020	LY294002 or Akt-siRNA inhibited the PI3K/Akt/FoxO3a pathway and promoted the Pristimerin-induced apoptosis, while Pristimerin effects were partially abolished in FoxO3a knockdown UM-1 cell cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	forkhead box O3	Homo sapiens	162-168
31748028-8	2020	Inhibitors of PI3K (LY294002) enhanced the phosphorylation of P38, AKT, and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mitogen-activated protein kinase 14	Homo sapiens	62-65
31748028-8	2020	Inhibitors of PI3K (LY294002) enhanced the phosphorylation of P38, AKT, and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	67-70
31748028-8	2020	Inhibitors of PI3K (LY294002) enhanced the phosphorylation of P38, AKT, and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mechanistic target of rapamycin kinase	Homo sapiens	76-80
32333783-8	2020	The effect of 2ME2 treatment on the promoter activity of hSR-BI/CLA-1 was abrogated by treatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase, as was the increase in HDL-induced eNOS activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	scavenger receptor class B member 1	Homo sapiens	57-63
32051533-6	2020	These phenomena could be reversed by the PI3K-Akt inhibitor LY294002, mTOR inhibitor rapamycin, PFKFB3 inhibitor 3PO, or PFKFB3 silencing by specific shRNA, or aerobic glycolysis inhibitor 2-DG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	46-49
32333783-8	2020	The effect of 2ME2 treatment on the promoter activity of hSR-BI/CLA-1 was abrogated by treatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase, as was the increase in HDL-induced eNOS activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	scavenger receptor class B member 1	Homo sapiens	64-69
32333783-8	2020	The effect of 2ME2 treatment on the promoter activity of hSR-BI/CLA-1 was abrogated by treatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase, as was the increase in HDL-induced eNOS activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	nitric oxide synthase 3	Homo sapiens	202-206
32552933-7	2020	After K562/ADR cells were treated with PI3K/AKT pathway inhibitor LY294002, the protein expressions of NF-kappaB and P-gp were analyzed to determine the regulation of AKT on the expression of NF-kappaB and P-gp.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	167-170
32061800-7	2020	NAC</protein-id> and the pharmacological inhibitor of Akt (LY294002), ERK1/2 (PD980590), and AMPKalpha (Compound C) markedly abrogated the Cr(VI)-induced activation of Akt, ERK1/2, and AMPKalpha signal, respectively, with the concomitant inhibition of mitochondrial dysfunction and caspase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	54-57
32179193-8	2020	Following administration of the PI3K-specific inhibitor LY294002, phosphorylation levels of AKT and mTOR decreased, and the ratio of LC3II/I was higher in the inhibitor-treated injury group than the simple-injury group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Rattus norvegicus	92-95
32552933-7	2020	After K562/ADR cells were treated with PI3K/AKT pathway inhibitor LY294002, the protein expressions of NF-kappaB and P-gp were analyzed to determine the regulation of AKT on the expression of NF-kappaB and P-gp.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	nuclear factor kappa B subunit 1	Homo sapiens	192-201
32179193-8	2020	Following administration of the PI3K-specific inhibitor LY294002, phosphorylation levels of AKT and mTOR decreased, and the ratio of LC3II/I was higher in the inhibitor-treated injury group than the simple-injury group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	mechanistic target of rapamycin kinase	Rattus norvegicus	100-104
32552933-15	2020	The protein expressions of p-AKT, P-gp and the activity of NF-kappaB were inhibited significantly by using PI3K/AKT inhibitor LY294002 (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	AKT serine/threonine kinase 1	Homo sapiens	29-32
32552933-15	2020	The protein expressions of p-AKT, P-gp and the activity of NF-kappaB were inhibited significantly by using PI3K/AKT inhibitor LY294002 (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	phosphoglycolate phosphatase	Homo sapiens	34-38
32552933-15	2020	The protein expressions of p-AKT, P-gp and the activity of NF-kappaB were inhibited significantly by using PI3K/AKT inhibitor LY294002 (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	nuclear factor kappa B subunit 1	Homo sapiens	59-68
32552933-15	2020	The protein expressions of p-AKT, P-gp and the activity of NF-kappaB were inhibited significantly by using PI3K/AKT inhibitor LY294002 (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	AKT serine/threonine kinase 1	Homo sapiens	112-115
32514271-8	2020	Pretreatment of the HNECs with T16Ainh-A01 and LY294002 attenuated these EGF-induced effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	epidermal growth factor	Homo sapiens	73-76
32458975-9	2020	When LY294002 was used to inhibit PI3K/AKT/mTOR signaling pathway, the effect of pcDNA3.1-SIK2 on aerobic glycolysis of breast cancer cells could be reversed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	AKT serine/threonine kinase 1	Homo sapiens	39-42
32458975-9	2020	When LY294002 was used to inhibit PI3K/AKT/mTOR signaling pathway, the effect of pcDNA3.1-SIK2 on aerobic glycolysis of breast cancer cells could be reversed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	mechanistic target of rapamycin kinase	Homo sapiens	43-47
32528253-10	2020	Further studies showed that both EpoB-enhanced migration and autophagy were increased/inhibited by inhibition/activation of PI3K/Akt signaling with LY294002 or IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Rattus norvegicus	129-132
32458975-9	2020	When LY294002 was used to inhibit PI3K/AKT/mTOR signaling pathway, the effect of pcDNA3.1-SIK2 on aerobic glycolysis of breast cancer cells could be reversed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	salt inducible kinase 2	Homo sapiens	90-94
32547216-7	2020	LY294002 was used to inhibit the activation of PI3K/AKT signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	52-55
32508639-12	2020	In addition, hypoxia-induced increases in PAP, cardiac hypertrophy, and lung expression of the proteins PI3K/Akt/mTOR/autophagy pathway were partially reversed by treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	AKT serine/threonine kinase 1	Rattus norvegicus	109-112
32508639-12	2020	In addition, hypoxia-induced increases in PAP, cardiac hypertrophy, and lung expression of the proteins PI3K/Akt/mTOR/autophagy pathway were partially reversed by treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	mechanistic target of rapamycin kinase	Rattus norvegicus	113-117
32547216-12	2020	Moreover, suppression of the PI3K/AKT signaling with LY294002 treatment apparently rescued TOP2A-mediated promotions in cell migration, invasion and EMT in Hela cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	34-37
32547216-12	2020	Moreover, suppression of the PI3K/AKT signaling with LY294002 treatment apparently rescued TOP2A-mediated promotions in cell migration, invasion and EMT in Hela cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	DNA topoisomerase II alpha	Homo sapiens	91-96
32431202-6	2020	LY294002 was used to inhibit the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	33-62
32382053-6	2020	Interruption of the AKT pathway with the specific inhibitor LY294002 could reverse the expression of MMPs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	20-23
32842368-10	2020	Compared with the NOX4+radiation group, the proliferation ability of nasopharyngeal carcinoma cells in the NOX4+radiation+LY294002 group was reduced (72 h absorbance (A) value: 0.79 vs. 0.56), while the apoptotic rate was increased (3.8% vs. 8.1%).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	NADPH oxidase 4	Homo sapiens	107-111
32458633-9	2020	Moreover, EHF inactivated the PI3K/Akt signaling pathway and LY294002, a PI3K/Akt inhibitor, increased the apoptosis-inducing effect of EHF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	thymoma viral proto-oncogene 1	Mus musculus	78-81
31997489-8	2020	LY294002, a PI3K inhibitor, inhibited AKT phosphorylation and rescued the tumor-promoting effect of EVA1 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	38-41
31997489-8	2020	LY294002, a PI3K inhibitor, inhibited AKT phosphorylation and rescued the tumor-promoting effect of EVA1 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	myelin protein zero like 2	Homo sapiens	100-104
32553076-5	2020	PI3K/AKT inhibitor LY294002 and ERK inhibitor U0126 decreased the expression of p-AKT, p-ERK and alpha-SMA, and increased the expression of E-Cadherin and Claudin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	5-8
32553076-5	2020	PI3K/AKT inhibitor LY294002 and ERK inhibitor U0126 decreased the expression of p-AKT, p-ERK and alpha-SMA, and increased the expression of E-Cadherin and Claudin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	82-85
32553076-5	2020	PI3K/AKT inhibitor LY294002 and ERK inhibitor U0126 decreased the expression of p-AKT, p-ERK and alpha-SMA, and increased the expression of E-Cadherin and Claudin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	mitogen-activated protein kinase 1	Homo sapiens	89-92
32553076-5	2020	PI3K/AKT inhibitor LY294002 and ERK inhibitor U0126 decreased the expression of p-AKT, p-ERK and alpha-SMA, and increased the expression of E-Cadherin and Claudin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	actin alpha 1, skeletal muscle	Homo sapiens	97-106
32553076-5	2020	PI3K/AKT inhibitor LY294002 and ERK inhibitor U0126 decreased the expression of p-AKT, p-ERK and alpha-SMA, and increased the expression of E-Cadherin and Claudin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	cadherin 1	Homo sapiens	140-150
32553076-5	2020	PI3K/AKT inhibitor LY294002 and ERK inhibitor U0126 decreased the expression of p-AKT, p-ERK and alpha-SMA, and increased the expression of E-Cadherin and Claudin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	claudin 1	Homo sapiens	155-164
32414166-9	2020	These were blocked by LY294002, which is an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	thymoma viral proto-oncogene 1	Mus musculus	44-47
31912683-11	2020	In Ishikawa 3-H-12 cells, radiosensitization effects and inhibition of AKT were achieved by PTEN restoration plus treatment with the phosphoinositide-3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Homo sapiens	71-74
32431202-6	2020	LY294002 was used to inhibit the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	70-73
32431202-11	2020	Inhibiting PI3K/AKT signaling pathway by using LY294002 blocked the positive role of NLRC5 in migration and invasion of AN3CA cells and expression of MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	16-19
32431202-11	2020	Inhibiting PI3K/AKT signaling pathway by using LY294002 blocked the positive role of NLRC5 in migration and invasion of AN3CA cells and expression of MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	NLR family CARD domain containing 5	Homo sapiens	85-90
32431202-11	2020	Inhibiting PI3K/AKT signaling pathway by using LY294002 blocked the positive role of NLRC5 in migration and invasion of AN3CA cells and expression of MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	matrix metallopeptidase 9	Homo sapiens	150-154
32016793-8	2020	However, the protective effect of DDW on cell survival and the DDW-mediated increases in p-Akt, Bcl-2 and GSK-3beta were abolished by pretreatment with the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	glycogen synthase kinase 3 alpha	Rattus norvegicus	106-115
32395075-11	2020	Furthermore, PD98059 (a selective ERK1/2 inhibitor) and LY294002 (a selective Akt inhibitor) decreased VSMC migration and proliferation by inhibiting phosphorylation of Akt and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	78-81
32395075-11	2020	Furthermore, PD98059 (a selective ERK1/2 inhibitor) and LY294002 (a selective Akt inhibitor) decreased VSMC migration and proliferation by inhibiting phosphorylation of Akt and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	169-172
32395075-11	2020	Furthermore, PD98059 (a selective ERK1/2 inhibitor) and LY294002 (a selective Akt inhibitor) decreased VSMC migration and proliferation by inhibiting phosphorylation of Akt and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	mitogen-activated protein kinase 3	Homo sapiens	177-183
32392915-11	2020	Furthermore, PD98059 (a selective ERK1/2 inhibitor) and LY294002 (a selective Akt inhibitor) decreased VSMC migration and proliferation by inhibiting phosphorylation of Akt and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	78-81
32392915-11	2020	Furthermore, PD98059 (a selective ERK1/2 inhibitor) and LY294002 (a selective Akt inhibitor) decreased VSMC migration and proliferation by inhibiting phosphorylation of Akt and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	169-172
32392915-11	2020	Furthermore, PD98059 (a selective ERK1/2 inhibitor) and LY294002 (a selective Akt inhibitor) decreased VSMC migration and proliferation by inhibiting phosphorylation of Akt and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	mitogen-activated protein kinase 3	Homo sapiens	177-183
32016793-8	2020	However, the protective effect of DDW on cell survival and the DDW-mediated increases in p-Akt, Bcl-2 and GSK-3beta were abolished by pretreatment with the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	156-185
32393432-8	2020	Moreover, the phosphorylation levels of Akt and Erk were upregulated in CCN2-over expressed cells, and LY294002 and U1026 (which inhibited the Akt and Erk signaling pathways, respectively) reversed the effect of CCN2 on autophagy and cell survival enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	AKT serine/threonine kinase 1	Homo sapiens	40-43
32393432-8	2020	Moreover, the phosphorylation levels of Akt and Erk were upregulated in CCN2-over expressed cells, and LY294002 and U1026 (which inhibited the Akt and Erk signaling pathways, respectively) reversed the effect of CCN2 on autophagy and cell survival enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	AKT serine/threonine kinase 1	Homo sapiens	143-146
32393432-8	2020	Moreover, the phosphorylation levels of Akt and Erk were upregulated in CCN2-over expressed cells, and LY294002 and U1026 (which inhibited the Akt and Erk signaling pathways, respectively) reversed the effect of CCN2 on autophagy and cell survival enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	mitogen-activated protein kinase 1	Homo sapiens	151-154
31935492-5	2020	This reduction was prevented by the PI3K inhibitor LY294002, indicating that there is a link between the PI3K/Akt pathway and the formation of ROS in the protective mechanisms of PostC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	110-113
32393432-8	2020	Moreover, the phosphorylation levels of Akt and Erk were upregulated in CCN2-over expressed cells, and LY294002 and U1026 (which inhibited the Akt and Erk signaling pathways, respectively) reversed the effect of CCN2 on autophagy and cell survival enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	cellular communication network factor 2	Homo sapiens	72-76
32393432-8	2020	Moreover, the phosphorylation levels of Akt and Erk were upregulated in CCN2-over expressed cells, and LY294002 and U1026 (which inhibited the Akt and Erk signaling pathways, respectively) reversed the effect of CCN2 on autophagy and cell survival enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	cellular communication network factor 2	Homo sapiens	212-216
32334633-12	2020	Silencing PENK promoted MG63 cell migration; however, treatment with LY294002 partially attenuated PENK silencing-induced OS cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	proenkephalin	Homo sapiens	99-103
32432052-7	2020	However, VEGF expression decreased after the pre-treatment with PI3K inhibitors (LY294002 and GDC-0941), ERK1/2 inhibitor (PD098059), and p38 MAPK inhibitor (SB203580), but not JNK inhibitor (SP600125), in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	vascular endothelial growth factor A	Homo sapiens	9-13
32373543-8	2020	By KEGG enrichment analysis and using the specific signaling pathway inhibitor LY294002 for inhibition of PI3K, IL-32 expression was significantly reduced (P < 0.001).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	interleukin 32	Homo sapiens	112-117
32382683-7	2020	Consistently, inhibition of Akt signaling by LY294002 attenuated the anti-oxidative activity of edaravone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
32373755-6	2020	Consistently, the activity of TP can be attenuated by the inhibition of TrkB or Akt by small chemicals K252a and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	72-76
32181480-12	2020	Notably, PI3K/AKT inhibitor LY294002 significantly inhibited the effects of HER4 via the downregulation of pAKT, Ki67, and MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	thymoma viral proto-oncogene 1	Mus musculus	14-17
32181480-12	2020	Notably, PI3K/AKT inhibitor LY294002 significantly inhibited the effects of HER4 via the downregulation of pAKT, Ki67, and MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	erb-b2 receptor tyrosine kinase 4	Mus musculus	76-80
32181480-12	2020	Notably, PI3K/AKT inhibitor LY294002 significantly inhibited the effects of HER4 via the downregulation of pAKT, Ki67, and MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	antigen identified by monoclonal antibody Ki 67	Mus musculus	113-117
32181480-12	2020	Notably, PI3K/AKT inhibitor LY294002 significantly inhibited the effects of HER4 via the downregulation of pAKT, Ki67, and MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	matrix metallopeptidase 9	Mus musculus	123-127
32181480-13	2020	Moreover, LY294002 markedly blocked the effects of HER4-induced upregulation of tumor malignancy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	erb-b2 receptor tyrosine kinase 4	Mus musculus	51-55
32373755-6	2020	Consistently, the activity of TP can be attenuated by the inhibition of TrkB or Akt by small chemicals K252a and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Rattus norvegicus	80-83
32215984-7	2020	The PI3K inhibitor LY294002 and PI3K agonist 740Y-P were used to regulate the PI3K/Akt pathway in EMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	thymoma viral proto-oncogene 1	Mus musculus	83-86
32318240-7	2020	Following the addition of LY294002, the levels of p-AKT, p-ERK1/2, and p-NF-kappaB decreased significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	52-55
32318240-7	2020	Following the addition of LY294002, the levels of p-AKT, p-ERK1/2, and p-NF-kappaB decreased significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	mitogen-activated protein kinase 3	Homo sapiens	59-65
32318240-7	2020	Following the addition of LY294002, the levels of p-AKT, p-ERK1/2, and p-NF-kappaB decreased significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	nuclear factor kappa B subunit 1	Homo sapiens	73-82
32328069-8	2020	C5b-9-stimulated SIRT1 expression was significantly reduced after pretreatment with c-jun antisense oligonucleotide, H7 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	sirtuin 1	Rattus norvegicus	17-22
31904495-16	2020	The expression of p-Akt and Bcl-2 decreased, while that of Bad and Bax increased in the LY + SCFL group compared with the SCFL group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-90	BCL2, apoptosis regulator	Rattus norvegicus	28-33
31904495-16	2020	The expression of p-Akt and Bcl-2 decreased, while that of Bad and Bax increased in the LY + SCFL group compared with the SCFL group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-90	BCL2 associated X, apoptosis regulator	Rattus norvegicus	67-70
32049549-9	2020	In addition, the capacity of NIC to protect CECs was fully reversed in the presence of the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	thymoma viral proto-oncogene 1	Mus musculus	91-94
32276610-10	2020	However, an AKT inhibitor (LY294002), an ERK inhibitor (U0126), a JNK inhibitor (SP600125), and a p38 inhibitor (SB203580) inhibited the increase of mineralization induced by PTHrP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	12-15
32276610-10	2020	However, an AKT inhibitor (LY294002), an ERK inhibitor (U0126), a JNK inhibitor (SP600125), and a p38 inhibitor (SB203580) inhibited the increase of mineralization induced by PTHrP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	parathyroid hormone like hormone	Homo sapiens	175-180
32033754-5	2020	CLEC5A-mediated GC proliferation and anti-apoptosis were impaired by blocking the PI3K/AKT/mTOR pathway with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	C-type lectin domain containing 5A	Homo sapiens	0-6
32033754-5	2020	CLEC5A-mediated GC proliferation and anti-apoptosis were impaired by blocking the PI3K/AKT/mTOR pathway with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	AKT serine/threonine kinase 1	Homo sapiens	87-90
32033754-5	2020	CLEC5A-mediated GC proliferation and anti-apoptosis were impaired by blocking the PI3K/AKT/mTOR pathway with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	mechanistic target of rapamycin kinase	Homo sapiens	91-95
32150448-7	2020	The protective effect of canagliflozin was diminished by the phosphatidylinositol 3-kinase/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	thymoma viral proto-oncogene 1	Mus musculus	91-94
31889370-5	2020	Further, LY294002, a PI3K/AKT antagonist, was employed to explore the mechanism underlying the effects of CCN5 in the regulation of OSCC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	26-29
31889370-5	2020	Further, LY294002, a PI3K/AKT antagonist, was employed to explore the mechanism underlying the effects of CCN5 in the regulation of OSCC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	cellular communication network factor 5	Homo sapiens	106-110
31889370-10	2020	Inhibiting PI3K/AKT signaling with LY294002 rescued the apoptotic process in CCN5-silenced OSCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	16-19
31889370-10	2020	Inhibiting PI3K/AKT signaling with LY294002 rescued the apoptotic process in CCN5-silenced OSCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	cellular communication network factor 5	Homo sapiens	77-81
32215984-12	2020	The promotive effect of p75NTR overexpression can be attenuated by LY294002, while the inhibitory effect of p75NTR knock-down on Runx2 and Col1 expression can be reversed by 740Y-P.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	24-30
32329876-5	2020	Finally, the PI3K/Akt signaling pathway inhibitor LY294002 was used to study the effect of TRIM59 on the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
32067282-8	2020	Additionally, the Akt signaling pathway was blocked with an Akt inhibitor, LY294002, to investigate its involvement in the regulatory effect of miR30a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	thymoma viral proto-oncogene 1	Mus musculus	18-21
32373981-5	2020	LY294002, an inhibitor of the PI3K/PDK1/Akt signaling pathway, was used to validate the mechanism by which STRAP protects cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	pyruvate dehydrogenase kinase 1	Rattus norvegicus	35-39
32373981-5	2020	LY294002, an inhibitor of the PI3K/PDK1/Akt signaling pathway, was used to validate the mechanism by which STRAP protects cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	40-43
32373981-5	2020	LY294002, an inhibitor of the PI3K/PDK1/Akt signaling pathway, was used to validate the mechanism by which STRAP protects cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	serine/threonine kinase receptor associated protein	Rattus norvegicus	107-112
32373981-9	2020	However, LY294002 attenuated the protective effect of STRAP on cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	serine/threonine kinase receptor associated protein	Rattus norvegicus	54-59
32067282-8	2020	Additionally, the Akt signaling pathway was blocked with an Akt inhibitor, LY294002, to investigate its involvement in the regulatory effect of miR30a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	thymoma viral proto-oncogene 1	Mus musculus	60-63
32067282-8	2020	Additionally, the Akt signaling pathway was blocked with an Akt inhibitor, LY294002, to investigate its involvement in the regulatory effect of miR30a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	microRNA 30a	Mus musculus	144-150
32222858-11	2020	Conversely, the use of LY294002 (an inhibitor of PI3K) blocked the activation of the PI3K/AKT signaling pathway and prevented the beneficial effects of rutin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	90-93
32037484-7	2020	E2-bovine serum albumin (BSA), a large molecular membrane-impenetrable conjugate of E2, can also upregulate MMP-9 protein expression in MCF-7, and the action of E2-BSA can be abolished by PI3K inhibitor LY294002; treating MCF-7 simultaneously with PELP1-shRNA and LY294002 did not show synergetic inhibitory effect on E2-BSA-induced MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	matrix metallopeptidase 9	Homo sapiens	108-113
32037484-7	2020	E2-bovine serum albumin (BSA), a large molecular membrane-impenetrable conjugate of E2, can also upregulate MMP-9 protein expression in MCF-7, and the action of E2-BSA can be abolished by PI3K inhibitor LY294002; treating MCF-7 simultaneously with PELP1-shRNA and LY294002 did not show synergetic inhibitory effect on E2-BSA-induced MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-272	matrix metallopeptidase 9	Homo sapiens	108-113
31753588-9	2020	CXCL16 stimulated the activation of PI3K/AKT/FOXO3a signaling pathway in MRC-5 cells, and the inhibition by specific inhibitors Wortmannin and LY294002, or knockdown of CXCR6 by siRNA also suppressed the biological functions of MRC-5 cells mediated by CXCL16.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	C-X-C motif chemokine ligand 16	Homo sapiens	0-6
31753588-9	2020	CXCL16 stimulated the activation of PI3K/AKT/FOXO3a signaling pathway in MRC-5 cells, and the inhibition by specific inhibitors Wortmannin and LY294002, or knockdown of CXCR6 by siRNA also suppressed the biological functions of MRC-5 cells mediated by CXCL16.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	AKT serine/threonine kinase 1	Homo sapiens	41-44
31753588-9	2020	CXCL16 stimulated the activation of PI3K/AKT/FOXO3a signaling pathway in MRC-5 cells, and the inhibition by specific inhibitors Wortmannin and LY294002, or knockdown of CXCR6 by siRNA also suppressed the biological functions of MRC-5 cells mediated by CXCL16.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	forkhead box O3	Homo sapiens	45-51
32150791-11	2020	Furthermore, pretreatment with LY294002, an inhibitor of PI3K/Akt/mTOR pathway, abolished the anti-apoptotic effect of PHLPP1 inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Rattus norvegicus	62-65
32150791-11	2020	Furthermore, pretreatment with LY294002, an inhibitor of PI3K/Akt/mTOR pathway, abolished the anti-apoptotic effect of PHLPP1 inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	mechanistic target of rapamycin kinase	Rattus norvegicus	66-70
32150791-11	2020	Furthermore, pretreatment with LY294002, an inhibitor of PI3K/Akt/mTOR pathway, abolished the anti-apoptotic effect of PHLPP1 inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	PH domain and leucine rich repeat protein phosphatase 1	Rattus norvegicus	119-125
30282494-15	2020	In addition, ACK1 and MMP2/9 were downregulated following treatment with LY294002, whereas ACK1 shRNA had no effect on phosphorylation of PI3K(p-PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	tyrosine kinase non receptor 2	Homo sapiens	13-17
30282494-15	2020	In addition, ACK1 and MMP2/9 were downregulated following treatment with LY294002, whereas ACK1 shRNA had no effect on phosphorylation of PI3K(p-PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	matrix metallopeptidase 2	Homo sapiens	22-28
32266254-9	2020	Our in vitro experimental results confirmed that both LY294002 and U0126 largely abolished the protective effect of FGF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	fibroblast growth factor 2	Rattus norvegicus	116-120
32057901-11	2020	Moreover, accumulation of ubiquitinated Arl4c protein was increased by HCPT and LY294002 (an AKT inhibitor) treatment whereas the proteasome inhibitor MG-132 attenuated the inhibitory effect of HCPT and LY294002 on Arl4c expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	ADP ribosylation factor like GTPase 4C	Homo sapiens	40-45
32057901-11	2020	Moreover, accumulation of ubiquitinated Arl4c protein was increased by HCPT and LY294002 (an AKT inhibitor) treatment whereas the proteasome inhibitor MG-132 attenuated the inhibitory effect of HCPT and LY294002 on Arl4c expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	93-96
32057901-11	2020	Moreover, accumulation of ubiquitinated Arl4c protein was increased by HCPT and LY294002 (an AKT inhibitor) treatment whereas the proteasome inhibitor MG-132 attenuated the inhibitory effect of HCPT and LY294002 on Arl4c expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	ADP ribosylation factor like GTPase 4C	Homo sapiens	40-45
32140824-11	2020	LY294002 can reverse the effect of PA on the expression of PI3K / Akt signaling pathway related protein in rats after I/R.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	66-69
32200515-7	2020	These effects were all weakened when PI3K/AKT pathway was inhibited by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Rattus norvegicus	42-45
32319377-6	2020	LY294002 decreased p-AKT expression, cell colony-forming ability and tumorigenicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	21-24
32256089-12	2020	Moreover, PI3K inhibitor LY294002 effectively inhibited activation of PI3K and AKT, and further repressed RAGE overexpression-induced cell proliferation and apoptosis inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	thymoma viral proto-oncogene 1	Mus musculus	79-82
32231420-6	2020	The PI3K/AKT signaling pathway in the colon tissue of rats was blocked using the PI3K/AKT signaling pathway inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Rattus norvegicus	9-12
32231420-6	2020	The PI3K/AKT signaling pathway in the colon tissue of rats was blocked using the PI3K/AKT signaling pathway inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Rattus norvegicus	86-89
32231420-13	2020	When the PI3K/AKT signaling pathway was inhibited, the apoptosis rate of colon tissue cells in the DSS + LY294002 group was significantly lower than that of the DSS group (P < 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
32184668-11	2020	Importantly, the PI3K inhibitor LY294002 strongly inhibited the expression of LETM1, pPI3K-p85, and pAkt (Thr308, Ser473) in PCa cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	leucine zipper and EF-hand containing transmembrane protein 1	Homo sapiens	78-83
31973819-4	2020	LY294002, an inhibitor of PI3K, inhibited the zinc-induced iron transport, DMT1, HEPH mRNA and protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	doublesex and mab-3 related transcription factor 1	Homo sapiens	75-79
31973819-4	2020	LY294002, an inhibitor of PI3K, inhibited the zinc-induced iron transport, DMT1, HEPH mRNA and protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hephaestin	Homo sapiens	81-85
31973819-5	2020	In addition, LY294002 also inhibited the basal expression of HEPH and FPN1 resulting in blockade of iron egress from cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	hephaestin	Homo sapiens	61-65
32265642-11	2020	More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	256-264	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	51-76
32265642-11	2020	More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	256-264	cAMP responsive element binding protein 1	Mus musculus	94-131
32265642-11	2020	More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	256-264	cAMP responsive element binding protein 1	Mus musculus	133-137
32218735-8	2020	Moreover, this neuroprotective effect was attenuated by the PI3K-Akt signaling pathway inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
31973819-5	2020	In addition, LY294002 also inhibited the basal expression of HEPH and FPN1 resulting in blockade of iron egress from cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	solute carrier family 40 member 1	Homo sapiens	70-74
32214801-13	2020	The phosphorylation level of AKT increased with time after 1,25(OH)2D3 treatment, while LY294002 weakened AKT phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Rattus norvegicus	106-109
32271399-5	2020	The inhibitor LY294002 was used to inhibit the PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	52-55
31877407-9	2020	The siRNA against RP1-93H18.6 or LY294002 exposure was observed to attenuate the effects induced by RP1-93H18.6 vectors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	RP1 axonemal microtubule associated	Homo sapiens	100-103
31918333-11	2020	The PI3K/Akt/FoxO pathway was identified to play a pivot role in TCS-induced glycolysis, which was further confirmed by inhibitor tests using specific inhibitors LY294002 and MK2206.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	AKT serine/threonine kinase 1	Homo sapiens	9-12
31678362-11	2020	PI3K inhibitor, LY294002, reversed the increasing proliferation level and cell progression of HPMECs induced by PEAR1 knockdown after LPS challenge.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	platelet endothelial aggregation receptor 1	Homo sapiens	112-117
31535378-11	2020	LY294002, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT pathway inhibitor, attenuated the decline in pAKT, but enhanced the decline in pmTOR and the increase in pULK1 following OPG treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	66-69
31535378-11	2020	LY294002, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT pathway inhibitor, attenuated the decline in pAKT, but enhanced the decline in pmTOR and the increase in pULK1 following OPG treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	191-194
31336024-10	2020	In vitro, a costimulating factor could obviously reduce the podocyte adhesion activity, including decreased expression of nephrin, podocin and adhesion molecule alpha3beta1 levels, to induce podocyte dysfunction, and the trends were markedly reversed by berberine and LY294002 therapy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	268-276	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	122-129
31336024-11	2020	Furthermore, reduction of PI3K and phosphorylated Akt levels were observed in the berberine (30 and 60 mumol/L) and LY294002 (40 mumol/L) treatment group, but the Akt protein expression showed little change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Rattus norvegicus	50-53
31336024-11	2020	Furthermore, reduction of PI3K and phosphorylated Akt levels were observed in the berberine (30 and 60 mumol/L) and LY294002 (40 mumol/L) treatment group, but the Akt protein expression showed little change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Rattus norvegicus	163-166
32016444-10	2020	The number of osteoclasts and the percentage of bone resorption in the miR-21 mimic + LY294002 group were lower than in the miR-21 mimic group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	microRNA 21a	Mus musculus	71-77
32067159-9	2020	With exposure to LY294002, PI3 kinase inhibitor, Akt phosphorylation diminished and CEPO-Fc protective effects disappeared.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	AKT serine/threonine kinase 1	Rattus norvegicus	49-52
32016444-13	2020	In the miR-21 mimic + LY294002 group, Pten protein expression was higher, and p-Akt and NFATc1 were lower than in the miR-21 mimic group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	microRNA 21a	Mus musculus	7-13
32016444-13	2020	In the miR-21 mimic + LY294002 group, Pten protein expression was higher, and p-Akt and NFATc1 were lower than in the miR-21 mimic group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	phosphatase and tensin homolog	Mus musculus	38-42
32016444-13	2020	In the miR-21 mimic + LY294002 group, Pten protein expression was higher, and p-Akt and NFATc1 were lower than in the miR-21 mimic group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	88-94
32016444-13	2020	In the miR-21 mimic + LY294002 group, Pten protein expression was higher, and p-Akt and NFATc1 were lower than in the miR-21 mimic group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	microRNA 21a	Mus musculus	118-124
32016453-11	2020	Finally, the inhibition of the PI3K/AKT/mTOR signaling pathway by LY294002 resulted in decreased fibroblast proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	36-39
32016453-11	2020	Finally, the inhibition of the PI3K/AKT/mTOR signaling pathway by LY294002 resulted in decreased fibroblast proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	mechanistic target of rapamycin kinase	Homo sapiens	40-44
32110051-12	2020	Vice versa, inhibition of PI3K/Akt pathway by LY294002 could resist the effect of FOXO6 overexpression on chemotherapy, cytotoxicity and glycolysis of HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	31-34
31872196-6	2020	The AKT inhibitor LY294002 and siRNA did not alter the action of resveratrol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	4-7
32112175-9	2020	In vitro, the PI3K inhibitors (BZE235 and LY294002) ameliorated GC insensitivity in H2O2/TNFalpha-induced IL-8 release from U937 cells by independently restoring the activity of HDAC2 or inhibiting the activation of transcription factors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	tumor necrosis factor	Homo sapiens	89-97
32112175-9	2020	In vitro, the PI3K inhibitors (BZE235 and LY294002) ameliorated GC insensitivity in H2O2/TNFalpha-induced IL-8 release from U937 cells by independently restoring the activity of HDAC2 or inhibiting the activation of transcription factors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
32112175-9	2020	In vitro, the PI3K inhibitors (BZE235 and LY294002) ameliorated GC insensitivity in H2O2/TNFalpha-induced IL-8 release from U937 cells by independently restoring the activity of HDAC2 or inhibiting the activation of transcription factors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	histone deacetylase 2	Homo sapiens	178-183
32110051-12	2020	Vice versa, inhibition of PI3K/Akt pathway by LY294002 could resist the effect of FOXO6 overexpression on chemotherapy, cytotoxicity and glycolysis of HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	forkhead box O6	Homo sapiens	82-87
31701812-9	2020	Inhibition of Akt (LY294002) resulted a significant increase in degeneration compared to HUCPVC co-cultures (48 +- 7% degeneration).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	14-17
32049100-9	2020	The results in the SULF2 group were quite the opposite in which SULF2 facilitated the growth of cervical cancer cells, which was reversed by LY294002 or U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	sulfatase 2	Mus musculus	19-24
32041571-9	2020	LY294002, a PI3K-AKT inhibitor, was able to reverse the promotive effect of EEC-CM or rhCXCL12 on EEC migration and invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	17-20
32103904-13	2020	Importantly, the cytoprotective effect of H2S against HG-induced injury was inhibited by LY294002 (an inhibitor of PI3K/Akt/eNOS signaling pathway).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	AKT serine/threonine kinase 1	Homo sapiens	120-123
32103904-13	2020	Importantly, the cytoprotective effect of H2S against HG-induced injury was inhibited by LY294002 (an inhibitor of PI3K/Akt/eNOS signaling pathway).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	nitric oxide synthase 3	Homo sapiens	124-128
32049100-9	2020	The results in the SULF2 group were quite the opposite in which SULF2 facilitated the growth of cervical cancer cells, which was reversed by LY294002 or U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	sulfatase 2	Mus musculus	64-69
30940294-8	2020	We further showed that downregulation of AKT signaling activity by using AKT inhibitor LY294002 markedly inhibited NSCLC cell proliferation and resistance to doxorubicin induced by VASH2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	41-44
30940294-8	2020	We further showed that downregulation of AKT signaling activity by using AKT inhibitor LY294002 markedly inhibited NSCLC cell proliferation and resistance to doxorubicin induced by VASH2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	73-76
30940294-8	2020	We further showed that downregulation of AKT signaling activity by using AKT inhibitor LY294002 markedly inhibited NSCLC cell proliferation and resistance to doxorubicin induced by VASH2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	vasohibin 2	Homo sapiens	181-186
31836533-7	2020	PlGF promoted the protein expression of eNOS by up-regulating AKT, and the AKT and eNOS protein levels were decreased after adding LY294002 (all P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	placental growth factor	Homo sapiens	0-4
31836533-7	2020	PlGF promoted the protein expression of eNOS by up-regulating AKT, and the AKT and eNOS protein levels were decreased after adding LY294002 (all P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	75-78
32174780-6	2020	S100A8 and S100A9 also induce the phosphorylation of AKT, ERK, p38 MAPK and JNK, and activation of NF-kappaB, which were blocked after exposure to TLR4i, LY294002, AKTi, PD98059, SB202190 or SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	S100 calcium binding protein A8	Homo sapiens	0-6
32174780-6	2020	S100A8 and S100A9 also induce the phosphorylation of AKT, ERK, p38 MAPK and JNK, and activation of NF-kappaB, which were blocked after exposure to TLR4i, LY294002, AKTi, PD98059, SB202190 or SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	S100 calcium binding protein A9	Homo sapiens	11-17
32174780-6	2020	S100A8 and S100A9 also induce the phosphorylation of AKT, ERK, p38 MAPK and JNK, and activation of NF-kappaB, which were blocked after exposure to TLR4i, LY294002, AKTi, PD98059, SB202190 or SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Homo sapiens	53-56
32174780-6	2020	S100A8 and S100A9 also induce the phosphorylation of AKT, ERK, p38 MAPK and JNK, and activation of NF-kappaB, which were blocked after exposure to TLR4i, LY294002, AKTi, PD98059, SB202190 or SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	mitogen-activated protein kinase 14	Homo sapiens	63-66
32174780-6	2020	S100A8 and S100A9 also induce the phosphorylation of AKT, ERK, p38 MAPK and JNK, and activation of NF-kappaB, which were blocked after exposure to TLR4i, LY294002, AKTi, PD98059, SB202190 or SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	mitogen-activated protein kinase 8	Homo sapiens	76-79
32174780-6	2020	S100A8 and S100A9 also induce the phosphorylation of AKT, ERK, p38 MAPK and JNK, and activation of NF-kappaB, which were blocked after exposure to TLR4i, LY294002, AKTi, PD98059, SB202190 or SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	nuclear factor kappa B subunit 1	Homo sapiens	99-108
32175411-12	2020	Furthermore, the inhibition of PI3K/Akt/MMP-9 by LY294002 and SB-3CT enhanced the anticancer effects of fentanyl.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	36-39
32175411-12	2020	Furthermore, the inhibition of PI3K/Akt/MMP-9 by LY294002 and SB-3CT enhanced the anticancer effects of fentanyl.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	matrix metallopeptidase 9	Homo sapiens	40-45
31891674-6	2020	Mechanistically, hUC-MSCs activated AKT pathway in macrophages, resulting in upregulation of M2-associated molecule Arg1, which was partly abolished by PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	AKT serine/threonine kinase 1	Homo sapiens	36-39
31918274-12	2020	The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	468-476	thymoma viral proto-oncogene 1	Mus musculus	53-56
31918274-12	2020	The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	468-476	G protein-coupled receptor 174	Mus musculus	106-112
31732769-0	2020	Notch1 and PI3K/Akt signaling blockers DAPT and LY294002 coordinately inhibit metastasis of gastric cancer through mutual enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	notch receptor 1	Homo sapiens	0-6
31732769-0	2020	Notch1 and PI3K/Akt signaling blockers DAPT and LY294002 coordinately inhibit metastasis of gastric cancer through mutual enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	16-19
31732769-3	2020	In this study, we aimed to investigate the effects of combined treatment with Notch1 signaling blocker DAPT and PI3K/Akt signal blocker LY294002 on metastasis of gastric cancer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	AKT serine/threonine kinase 1	Homo sapiens	117-120
31732769-7	2020	Migration and invasion potential of SGC7901 cells, EMT biomarkers and MMP-9 in SGC7901 cells, and metastasis of gastric cancer to lungs in mice were coordinately inhibited by DAPT and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	IL2 inducible T cell kinase	Homo sapiens	51-54
31732769-7	2020	Migration and invasion potential of SGC7901 cells, EMT biomarkers and MMP-9 in SGC7901 cells, and metastasis of gastric cancer to lungs in mice were coordinately inhibited by DAPT and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	matrix metallopeptidase 9	Homo sapiens	70-75
31732769-8	2020	In addition, DAPT and LY294002 coordinately inhibited the levels of Notch1, HES1, and p-Akt in gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	notch receptor 1	Homo sapiens	68-74
31732769-8	2020	In addition, DAPT and LY294002 coordinately inhibited the levels of Notch1, HES1, and p-Akt in gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	hes family bHLH transcription factor 1	Homo sapiens	76-80
31732769-8	2020	In addition, DAPT and LY294002 coordinately inhibited the levels of Notch1, HES1, and p-Akt in gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Homo sapiens	88-91
31666191-10	2020	Extracellular TG2 promoted the phosphorylation of Akt, mechanistic target of rapamycin (mTOR), and ribosomal p70 S6 kinase (p70S6K), and inhibitors of mTOR, phosphatidylinositol 3-kinase, and Src (rapamycin, LY294002, and Src I1, respectively) inhibited TG2-increased phosphorylation of mTOR and p70S6K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	transglutaminase 2, C polypeptide	Mus musculus	14-17
31918274-12	2020	The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	thymoma viral proto-oncogene 1	Mus musculus	53-56
31918274-12	2020	The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	G protein-coupled receptor 174	Mus musculus	106-112
31918274-12	2020	The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	induction of brown adipocytes 1	Mus musculus	162-167
31918274-12	2020	The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	tumor necrosis factor	Mus musculus	169-196
31918274-12	2020	The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	tumor necrosis factor	Mus musculus	198-207
31918274-12	2020	The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	interleukin 6	Mus musculus	213-231
31918274-12	2020	The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	thymoma viral proto-oncogene 1	Mus musculus	355-358
31918274-12	2020	The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	363-372
31918274-12	2020	The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	G protein-coupled receptor 174	Mus musculus	407-413
31891674-6	2020	Mechanistically, hUC-MSCs activated AKT pathway in macrophages, resulting in upregulation of M2-associated molecule Arg1, which was partly abolished by PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	arginase 1	Homo sapiens	116-120
31974627-9	2020	The present results showed that LY294002 downregulated the expression of PI3K, CYP2E1, AKT, mTOR and P70S6K (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	79-85
31894254-8	2020	In addition, LY294002, an Akt inhibitor, inhibited the phosphorylation of ERK, and U0126, an ERK inhibitor, inhibited the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	26-29
31894254-8	2020	In addition, LY294002, an Akt inhibitor, inhibited the phosphorylation of ERK, and U0126, an ERK inhibitor, inhibited the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	mitogen-activated protein kinase 1	Homo sapiens	74-77
31789415-6	2020	In addition, the effects of leptin stimulation were significantly counteracted by the AKT inhibitor LY294002, whereas the effects of leptin silencing were counteracted by AKT activator insulin-like growth factor 1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	AKT serine/threonine kinase 1	Homo sapiens	86-89
31705880-11	2020	Lastly, we blocked PI3K expression using an inhibitor LY294002, which downregulated the expression of LETM1, pPI3K-p85, and pAkt-Thr308.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	leucine zipper and EF-hand containing transmembrane protein 1	Homo sapiens	102-107
31939617-7	2020	In addition, the GSK-3beta phosphorylation and c-Fos expression were suppressed by PI3K/Akt pathway inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	glycogen synthase kinase 3 alpha	Homo sapiens	17-26
31939617-7	2020	In addition, the GSK-3beta phosphorylation and c-Fos expression were suppressed by PI3K/Akt pathway inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-52
31939617-7	2020	In addition, the GSK-3beta phosphorylation and c-Fos expression were suppressed by PI3K/Akt pathway inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Homo sapiens	88-91
31974627-9	2020	The present results showed that LY294002 downregulated the expression of PI3K, CYP2E1, AKT, mTOR and P70S6K (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	87-90
31974627-9	2020	The present results showed that LY294002 downregulated the expression of PI3K, CYP2E1, AKT, mTOR and P70S6K (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	mechanistic target of rapamycin kinase	Homo sapiens	92-96
31974627-9	2020	The present results showed that LY294002 downregulated the expression of PI3K, CYP2E1, AKT, mTOR and P70S6K (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	ribosomal protein S6 kinase B1	Homo sapiens	101-107
31868203-5	2020	Notably, we determined that bFGF activates PI3K/Akt signaling, and treatment with the PI3K/Akt inhibitor LY294002 inhibited bleomycin-induced cell morphology changes and EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	91-94
31894281-8	2020	Immunofluorescence and western blot analysis revealed that AnxA2 promoted CCL18-induced EMT via the PI3K/Akt/GSK3beta/Snail signaling pathway, and LY294002 inhibited the phosphorylation of AnxA2 in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	C-C motif chemokine ligand 18	Homo sapiens	74-79
31894281-8	2020	Immunofluorescence and western blot analysis revealed that AnxA2 promoted CCL18-induced EMT via the PI3K/Akt/GSK3beta/Snail signaling pathway, and LY294002 inhibited the phosphorylation of AnxA2 in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	glycogen synthase kinase 3 beta	Homo sapiens	109-117
31894281-8	2020	Immunofluorescence and western blot analysis revealed that AnxA2 promoted CCL18-induced EMT via the PI3K/Akt/GSK3beta/Snail signaling pathway, and LY294002 inhibited the phosphorylation of AnxA2 in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	annexin A2	Homo sapiens	189-194
31868203-6	2020	In addition, the effects of LY294002 on bleomycin-induced EMT were inhibited by ESRP1 silencing in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	epithelial splicing regulatory protein 1	Homo sapiens	80-85
32275004-12	2020	(2) Part two experiment: intervention with phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway inhibitor LY294002 to further explore the mechanism of dexamethasone in reducing lung injury induced by LIRI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
32027262-1	2020	OBJECTIVE: To investigate the proliferation inhibition and pro-apoptosis effect of LY294002 (PI3K/AKT inhibtor) combined with daunorubicin (DNR) on the chronic myeloid leurenia cell line K562 and its possible mechanisms.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	AKT serine/threonine kinase 1	Homo sapiens	98-101
32082121-6	2019	LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), partially reversed these therapeutic effects, suggesting that the PI3K/protein kinase B (Akt) pathway was involved.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	26-51
32082121-6	2019	LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), partially reversed these therapeutic effects, suggesting that the PI3K/protein kinase B (Akt) pathway was involved.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	149-152
31727367-6	2020	We also found that the PI3K/AKT pathway inhibitor LY294002 could revert the changes caused by FAM60A upregulation in HGC-27 and AGS cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	28-31
32063860-6	2019	However, these effects of HMGB1 were abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	high mobility group box 1	Rattus norvegicus	26-31
31992313-9	2020	However, when the PI3K/Akt pathway was inhibited by LY294002, the cell apoptosis and caspase 3 activity significantly increased while the cell viability was obviously inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	23-26
31992313-9	2020	However, when the PI3K/Akt pathway was inhibited by LY294002, the cell apoptosis and caspase 3 activity significantly increased while the cell viability was obviously inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	caspase 3	Homo sapiens	85-94
31727367-6	2020	We also found that the PI3K/AKT pathway inhibitor LY294002 could revert the changes caused by FAM60A upregulation in HGC-27 and AGS cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	SIN3-HDAC complex associated factor	Homo sapiens	94-100
31756335-11	2020	Moreover, triptolide cotreatment with the phosphatidylinositol 3 kinase (PI3k) inhibitor, 2-(4-morpholinyl)-8-phenylchromone (LY294002), could further suppress the proliferation, NF-kappaB activation and cyclinD1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	42-71
32051827-5	2020	Moreover, the PI3K/AKT inhibitor LY294002 was used to examine the relationship between TRIM32 and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	tripartite motif containing 32	Homo sapiens	87-93
32051827-5	2020	Moreover, the PI3K/AKT inhibitor LY294002 was used to examine the relationship between TRIM32 and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Homo sapiens	98-101
31963684-9	2020	Moreover, Rg5-induced apoptosis and autophagy could be dramatically strengthened by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	AKT serine/threonine kinase 1	Homo sapiens	93-96
31669540-9	2020	15-Keto PGE2 activated AKT signaling, and the pharmacological AKT inhibitor, LY294002 suppressed the 15-keto PGE2-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	23-26
31669540-9	2020	15-Keto PGE2 activated AKT signaling, and the pharmacological AKT inhibitor, LY294002 suppressed the 15-keto PGE2-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	62-65
31669540-9	2020	15-Keto PGE2 activated AKT signaling, and the pharmacological AKT inhibitor, LY294002 suppressed the 15-keto PGE2-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	heme oxygenase 1	Homo sapiens	122-126
31770525-5	2020	The presence of PI3K inhibitor (LY294002) or MEK inhibitor (U0126) or prior silencing of beta-catenin with siRNA suppressed LTB4-induced cyclin D1 up-regulation and PASMCs proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	cyclin D1	Rattus norvegicus	137-146
31756335-11	2020	Moreover, triptolide cotreatment with the phosphatidylinositol 3 kinase (PI3k) inhibitor, 2-(4-morpholinyl)-8-phenylchromone (LY294002), could further suppress the proliferation, NF-kappaB activation and cyclinD1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	nuclear factor kappa B subunit 1	Homo sapiens	179-188
31756335-11	2020	Moreover, triptolide cotreatment with the phosphatidylinositol 3 kinase (PI3k) inhibitor, 2-(4-morpholinyl)-8-phenylchromone (LY294002), could further suppress the proliferation, NF-kappaB activation and cyclinD1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	cyclin D1	Homo sapiens	204-212
31809756-11	2020	When Akt and p53 were suppressed by LY294002 and PFTalpha, respectively, sesamin exerted no additional effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	5-8
31809756-11	2020	When Akt and p53 were suppressed by LY294002 and PFTalpha, respectively, sesamin exerted no additional effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	tumor protein p53	Homo sapiens	13-16
31910234-13	2020	However, we found that the PI3K inhibitor LY294002 reduced GSK3beta pS9, and concomitantly decreased Snail1 levels (a GSK3beta target and Epithelial-to-Mesenchymal transition marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	glycogen synthase kinase 3 beta	Homo sapiens	59-67
31940823-6	2020	None of these changes had an influence on apoptosis; however, the inhibition of PI3K using the LY294002 compound revealed that the PI3K/AKT/FoxO3a pathway was involved in apoptosis evasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	136-139
31940823-6	2020	None of these changes had an influence on apoptosis; however, the inhibition of PI3K using the LY294002 compound revealed that the PI3K/AKT/FoxO3a pathway was involved in apoptosis evasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	forkhead box O3	Homo sapiens	140-146
32399049-7	2020	The effects of PUR, such as antiapoptosis, cell viability restoration, antioxidation, and mitochondrial maintenance, were all counteracted by application of the PI3K/Akt pathway inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	AKT serine/threonine kinase 1	Rattus norvegicus	166-169
32071545-8	2020	Inhibition of PI3K/AKT with LY294002 or FAM49B expression abrogated Myc-TASP1/Lv-shTASP1-induced GBC cell proliferation and motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	19-22
31910234-13	2020	However, we found that the PI3K inhibitor LY294002 reduced GSK3beta pS9, and concomitantly decreased Snail1 levels (a GSK3beta target and Epithelial-to-Mesenchymal transition marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	taste 2 receptor member 2, pseudogene	Homo sapiens	68-71
31910234-13	2020	However, we found that the PI3K inhibitor LY294002 reduced GSK3beta pS9, and concomitantly decreased Snail1 levels (a GSK3beta target and Epithelial-to-Mesenchymal transition marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	snail family transcriptional repressor 1	Homo sapiens	101-107
31910234-13	2020	However, we found that the PI3K inhibitor LY294002 reduced GSK3beta pS9, and concomitantly decreased Snail1 levels (a GSK3beta target and Epithelial-to-Mesenchymal transition marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	glycogen synthase kinase 3 beta	Homo sapiens	118-126
31910234-14	2020	The effects of LY294002 were observed also in CK2beta-downregulated cells, suggesting that reducing GSK3beta pS9 could be a strategy to control Snail1 levels in any situation where CK2beta is defective, as possibly occurring in cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	casein kinase 2 beta	Homo sapiens	46-53
31910234-14	2020	The effects of LY294002 were observed also in CK2beta-downregulated cells, suggesting that reducing GSK3beta pS9 could be a strategy to control Snail1 levels in any situation where CK2beta is defective, as possibly occurring in cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	glycogen synthase kinase 3 beta	Homo sapiens	100-108
31910234-14	2020	The effects of LY294002 were observed also in CK2beta-downregulated cells, suggesting that reducing GSK3beta pS9 could be a strategy to control Snail1 levels in any situation where CK2beta is defective, as possibly occurring in cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	taste 2 receptor member 2, pseudogene	Homo sapiens	109-112
31910234-14	2020	The effects of LY294002 were observed also in CK2beta-downregulated cells, suggesting that reducing GSK3beta pS9 could be a strategy to control Snail1 levels in any situation where CK2beta is defective, as possibly occurring in cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	snail family transcriptional repressor 1	Homo sapiens	144-150
31910234-14	2020	The effects of LY294002 were observed also in CK2beta-downregulated cells, suggesting that reducing GSK3beta pS9 could be a strategy to control Snail1 levels in any situation where CK2beta is defective, as possibly occurring in cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	casein kinase 2 beta	Homo sapiens	181-188
32054305-9	2020	In addition, PD98059 (ERK inhibitor) and LY294002 (AKT inhibitor) obviously reduced cell invasion and expression of metastasis-associated proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	51-54
31998447-6	2020	Inhibiting the PI3K/Akt pathway with LY294002 partly reversed the therapeutic effects of metformin on SCI in vitro and vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	20-23
31998447-9	2020	We also found that the Nrf2 transcription was partially reduced by LY294002 in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	NFE2 like bZIP transcription factor 2	Homo sapiens	23-27
32033632-7	2020	LY294002, a PI3K inhibitor, abolished cytoprotective effects of STVNa by inhibiting activation of Akt and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
32033632-7	2020	LY294002, a PI3K inhibitor, abolished cytoprotective effects of STVNa by inhibiting activation of Akt and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 alpha	Rattus norvegicus	106-115
31889183-11	2020	Enteric nerve cells that were incubated with LY294002 and transfected with a Sp1-knockdown vector displayed decreased levels of CSE production, which led to a decrease in H2S production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	cystathionine gamma-lyase	Rattus norvegicus	128-131
32841049-10	2020	Inhibition of PI3K/Akt by LY294002 reversed the effects of TRIM8 knockdown on cell viability, oxidative stress, and apoptosis of H9c2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
32879215-3	2020	Activity of mitogen-activated protein kinase (MAPK) was increased in the tumor cells treated with E2, and enhanced secretion of LPL was suppressed by MAPK kinase 1/2 inhibitor, PD98059, extracellular signal-regulated kinase (ERK) 1/2 inhibitor, FR180204, p38 MAPK inhibitor, SB202190, and phosphatidyl inositol 3-kinase (PI3K) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	338-346	lipoprotein lipase	Mus musculus	128-131
32452221-7	2020	This might be attributed to the activation of PI3K/Akt signaling pathway in BMSCs that is downstream of CXCR4, as demonstrated by the use of the CXCR4 antagonist AMD3100 and PI3K pathway inhibitor LY294002 assays in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	AKT serine/threonine kinase 1	Rattus norvegicus	51-54
32452221-7	2020	This might be attributed to the activation of PI3K/Akt signaling pathway in BMSCs that is downstream of CXCR4, as demonstrated by the use of the CXCR4 antagonist AMD3100 and PI3K pathway inhibitor LY294002 assays in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	C-X-C motif chemokine receptor 4	Rattus norvegicus	104-109
32055597-13	2020	Western blot results showed that the expression of P-AKT increased after EA treatment and decreased after LY294002, an inhibitor of the PI3K/AKT pathway, treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	thymoma viral proto-oncogene 1	Mus musculus	53-56
32864999-11	2020	Inhibition of the PI3K/Akt pathway by a specific inhibitor, LY294002, partially reduced the protective effect of HuMSC-EVs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	23-26
32841049-10	2020	Inhibition of PI3K/Akt by LY294002 reversed the effects of TRIM8 knockdown on cell viability, oxidative stress, and apoptosis of H9c2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	tripartite motif-containing 8	Rattus norvegicus	59-64
32404561-7	2020	Dexamethasone (Dex) could partly attenuate NaHS-mediated claudin-5 downregulation, and the protective effects of Dex could be partially blocked by LY294002, a PI3K/AKT/FoxO1 pathway antagonist.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	claudin 5	Homo sapiens	57-66
32400333-6	2020	Of note, the PI3K/AKT inhibitor (LY294002) abrogated the protective effects of low-dose sevoflurane on CPB-POCD rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
31557635-10	2020	GM-CSF activated p-Akt and increased expressions of p70S6K and c-Jun, which were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	colony stimulating factor 2	Homo sapiens	0-6
31557635-10	2020	GM-CSF activated p-Akt and increased expressions of p70S6K and c-Jun, which were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	ribosomal protein S6 kinase B1	Homo sapiens	52-58
31557635-10	2020	GM-CSF activated p-Akt and increased expressions of p70S6K and c-Jun, which were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-68
31586300-3	2020	The object of this study is recognition of the possible role of mTOR kinase inhibitors-everolimus single and in combination with selected downstream protein kinases inhibitors: LY294002 (PI3 K), U0126 (ERK1/2), GDC-0879 (B-RAF), AS-703026 (MEK), MK-2206 (AKT), PLX-4032 (B-RRAF) in cell invasion in malignant melanoma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	mechanistic target of rapamycin kinase	Homo sapiens	64-68
31706751-12	2020	The LY294002 weakened the effect of TNC gene silencing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	tenascin C	Rattus norvegicus	36-39
33172292-10	2020	Additionally, treatment with LY294002 reserved the protective effects of GLA on H/R-stimulated oxidative injury in H9c2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	galactosidase, alpha	Rattus norvegicus	73-76
31586300-7	2020	Slightly less profound reduction of invasiveness was obtained for the combinations of an mTOR inhibitor-everolimus with ERK1/2 inhibitor-U126 or MEK inhibitor-AS-703026 and in the case of MMPs activity decrease for PI3 K inhibitor-LY294002 and AKT inhibitor-MK-2206.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	231-239	mechanistic target of rapamycin kinase	Homo sapiens	89-93
31586300-7	2020	Slightly less profound reduction of invasiveness was obtained for the combinations of an mTOR inhibitor-everolimus with ERK1/2 inhibitor-U126 or MEK inhibitor-AS-703026 and in the case of MMPs activity decrease for PI3 K inhibitor-LY294002 and AKT inhibitor-MK-2206.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	231-239	peptidase inhibitor 3	Homo sapiens	215-218
31712854-12	2020	Besides, the expression of p-AKT (Ser473) and p-PI3K was significantly upregulated by employing miR-140-5p inhibitor, but retrieved after treating with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	AKT serine/threonine kinase 1	Homo sapiens	29-32
31712854-12	2020	Besides, the expression of p-AKT (Ser473) and p-PI3K was significantly upregulated by employing miR-140-5p inhibitor, but retrieved after treating with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	microRNA 140	Homo sapiens	96-103
31883035-9	2020	Administration of LY294002, a specific PI3K pathway inhibitor, significantly reversed all the effects of miR-22 on rats in the model group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	microRNA 22	Rattus norvegicus	105-111
31605630-7	2020	Pretreatment of LY294002 (a PI3K inhibitor) or rapamycin (an mTOR inhibitor) markedly reduced EGF-induced motility and p-AKT/p-mTOR/c-Jun/Sp1 expression when combined with melatonin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	epidermal growth factor	Homo sapiens	94-97
31605630-7	2020	Pretreatment of LY294002 (a PI3K inhibitor) or rapamycin (an mTOR inhibitor) markedly reduced EGF-induced motility and p-AKT/p-mTOR/c-Jun/Sp1 expression when combined with melatonin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	121-124
31605630-7	2020	Pretreatment of LY294002 (a PI3K inhibitor) or rapamycin (an mTOR inhibitor) markedly reduced EGF-induced motility and p-AKT/p-mTOR/c-Jun/Sp1 expression when combined with melatonin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	mechanistic target of rapamycin kinase	Homo sapiens	127-131
31605630-7	2020	Pretreatment of LY294002 (a PI3K inhibitor) or rapamycin (an mTOR inhibitor) markedly reduced EGF-induced motility and p-AKT/p-mTOR/c-Jun/Sp1 expression when combined with melatonin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-137
32404561-7	2020	Dexamethasone (Dex) could partly attenuate NaHS-mediated claudin-5 downregulation, and the protective effects of Dex could be partially blocked by LY294002, a PI3K/AKT/FoxO1 pathway antagonist.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	forkhead box O1	Homo sapiens	168-173
30843033-7	2020	Furthermore, the combination treatment of OTA and signaling inhibitors (LY294002, U0126, or SP600125) exerted synergistic antiproliferative effects in TM3 and TM4 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	tropomyosin 1, alpha	Mus musculus	151-154
31746379-10	2020	The PI3K specific inhibitor LY294002 significantly decreased 4EBP1 expression and reduced p-AKT and p-mTOR expression compared with the mechanical stress group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	61-66
31602539-9	2020	ADSC-CM pretreatment significantly increased pAkt protein expression, and ECM protein expression greatly decreased in case of LY294002 application.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	multimerin 1	Homo sapiens	74-77
31746379-10	2020	The PI3K specific inhibitor LY294002 significantly decreased 4EBP1 expression and reduced p-AKT and p-mTOR expression compared with the mechanical stress group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	92-95
31746379-10	2020	The PI3K specific inhibitor LY294002 significantly decreased 4EBP1 expression and reduced p-AKT and p-mTOR expression compared with the mechanical stress group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	mechanistic target of rapamycin kinase	Homo sapiens	102-106
31607135-5	2020	Overexpression of PCNA protein decreases GSK3beta Ser9 phosphorylation, whereas knockdown of PCNA using small interfering RNA (siRNA) increased Ser9 phosphorylated GSK3beta, which was attenuated by phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 after UVC irradiation, indicating the involvement of the PI3K-AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	proliferating cell nuclear antigen	Homo sapiens	18-22
31607135-5	2020	Overexpression of PCNA protein decreases GSK3beta Ser9 phosphorylation, whereas knockdown of PCNA using small interfering RNA (siRNA) increased Ser9 phosphorylated GSK3beta, which was attenuated by phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 after UVC irradiation, indicating the involvement of the PI3K-AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	proliferating cell nuclear antigen	Homo sapiens	93-97
31607135-5	2020	Overexpression of PCNA protein decreases GSK3beta Ser9 phosphorylation, whereas knockdown of PCNA using small interfering RNA (siRNA) increased Ser9 phosphorylated GSK3beta, which was attenuated by phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 after UVC irradiation, indicating the involvement of the PI3K-AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	glycogen synthase kinase 3 beta	Homo sapiens	164-172
31790897-10	2020	In addition, mechanism investigation showed that CPT increased the phosphorylation of phosphoinositide 3-kinase (PI3K), protein kinase B (Akt) and glycogen synthase-3beta (GSK3beta) in vivo and in vitro models, which were abrogated by PI3K inhibitor LY294002 in vitro models.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	250-258	choline phosphotransferase 1	Homo sapiens	49-52
31170866-12	2020	Importantly, LY294002 (PI3K inhibitor) or si-ABCA1 completely inhibited the stimulatory effects of miR-33-5p inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	microRNA 335	Homo sapiens	99-108
31600563-5	2020	These protective effects of DHPG and VU0092273 were prevented by inhibition of PI3K/Akt pathway by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	AKT serine/threonine kinase 1	Homo sapiens	84-87
31536856-8	2020	Pretreatment with 1,25(OH)2 D3 and LY294002 (phosphoinositide 3-kinase [PIK3] inhibitor) significantly inhibited the IS-induced phosphorylation of Akt and beta-catenin, nuclear beta-catenin accumulation, and EMT-associated protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	72-76
31536856-8	2020	Pretreatment with 1,25(OH)2 D3 and LY294002 (phosphoinositide 3-kinase [PIK3] inhibitor) significantly inhibited the IS-induced phosphorylation of Akt and beta-catenin, nuclear beta-catenin accumulation, and EMT-associated protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	147-150
31536856-8	2020	Pretreatment with 1,25(OH)2 D3 and LY294002 (phosphoinositide 3-kinase [PIK3] inhibitor) significantly inhibited the IS-induced phosphorylation of Akt and beta-catenin, nuclear beta-catenin accumulation, and EMT-associated protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	catenin beta 1	Homo sapiens	155-167
31536856-8	2020	Pretreatment with 1,25(OH)2 D3 and LY294002 (phosphoinositide 3-kinase [PIK3] inhibitor) significantly inhibited the IS-induced phosphorylation of Akt and beta-catenin, nuclear beta-catenin accumulation, and EMT-associated protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	catenin beta 1	Homo sapiens	177-189
31920397-11	2019	Compared with the control group, treatment with the inhibitor LY294002 alone significantly inhibited cell proliferation and promoted apoptosis (p&lt;0.05); this effect was similar to that observed in the silencing PRDX1 group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	peroxiredoxin 1	Homo sapiens	214-219
31587435-10	2020	However, the angiogenesis and fibroblast activation of mir-27b inhibitor was reversed by LY294002, and the activate effect to PI3K/AKT pathway was also inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	microRNA 27b	Homo sapiens	55-62
31905887-11	2019	LY294002 as specific AKT inhibitor was used to confirm that AKT inactivation may promote anticancer effect of sorafenib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	21-24
31905887-11	2019	LY294002 as specific AKT inhibitor was used to confirm that AKT inactivation may promote anticancer effect of sorafenib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	60-63
31905967-7	2019	In addition, LPS-stimulated binding of c-Jun to the MMP-9 promoter was confirmed by chromatin immunoprecipitation (ChIP) assay, which was blocked by pretreatment with c-Src inhibitor II, PF431396, AG1296, LY294002, Akt inhibitor VIII, p38 MAP kinase inhibitor VIII, SP600125, and tanshinone IIA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	matrix metallopeptidase 9	Rattus norvegicus	52-57
31905967-7	2019	In addition, LPS-stimulated binding of c-Jun to the MMP-9 promoter was confirmed by chromatin immunoprecipitation (ChIP) assay, which was blocked by pretreatment with c-Src inhibitor II, PF431396, AG1296, LY294002, Akt inhibitor VIII, p38 MAP kinase inhibitor VIII, SP600125, and tanshinone IIA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	167-172
31614141-8	2019	Compound C (an AMPK inhibitor) and LY294002 (a PI3K inhibitor) markedly reversed the alleviating effect of 10-HDA on the expression of tight junction proteins, indicating that 10-HDA inhibited LPS-induced BBB dysfunction by triggering the activation of the AMPK/PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	257-261
31920339-10	2019	Moreover, a PI3K/AKT inhibitor LY294002 was utilized to examine the connection between ARHGAP10 and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	17-20
31920339-10	2019	Moreover, a PI3K/AKT inhibitor LY294002 was utilized to examine the connection between ARHGAP10 and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	Rho GTPase activating protein 10	Homo sapiens	87-95
31920339-10	2019	Moreover, a PI3K/AKT inhibitor LY294002 was utilized to examine the connection between ARHGAP10 and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	100-103
31920339-11	2019	Our findings demonstrated that the AKT inhibitor LY294002 could rescue the function of ARHGAP10 in CRC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	35-38
31920339-11	2019	Our findings demonstrated that the AKT inhibitor LY294002 could rescue the function of ARHGAP10 in CRC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	Rho GTPase activating protein 10	Homo sapiens	87-95
31920923-8	2019	In vitro, treatment of PC12 cells with 100 muM SEH markedly reduced cell death induced by oxygen-glucose deprivation through the activation of PI3K/Akt/nuclear factor kappa B pathway, and the therapeutic effect of SEH was obviously inhibited by 10 muM LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	252-260	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	143-174
31614141-8	2019	Compound C (an AMPK inhibitor) and LY294002 (a PI3K inhibitor) markedly reversed the alleviating effect of 10-HDA on the expression of tight junction proteins, indicating that 10-HDA inhibited LPS-induced BBB dysfunction by triggering the activation of the AMPK/PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	267-270
31544532-9	2019	Furthermore, rrOPN promoted the expression of p-STAT3 and p-AKT, while OPN-Ab and PI3K/Akt inhibitor LY294002 both inhibited the expressions of p-AKT and Bcl2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Rattus norvegicus	87-90
31806860-11	2019	The upregulation function of the PI3K inhibitor on the expression of NF-kappaB, IL-6, IL-1ss, and TLR4 in LPS rats was not obvious, but the expression of TNF-a in LPS+LY294002 rats was increased by 22.85% compared with that in LPS rats (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	tumor necrosis factor	Rattus norvegicus	154-159
31827318-6	2019	The effects on key targets and the AKT pathway were verified by Western blotting in experiments with the AKT inhibitor LY294002 or activator SC79.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Rattus norvegicus	35-38
31827318-6	2019	The effects on key targets and the AKT pathway were verified by Western blotting in experiments with the AKT inhibitor LY294002 or activator SC79.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Rattus norvegicus	105-108
31827318-11	2019	Furthermore, the presence of the AKT inhibitor LY294002 had a similar inhibitory effect as HJT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
31885814-8	2019	Consistent with Nrf2 knockdown, the PI3K/Akt inhibitor LY294002 significantly suppressed RSV-induced Nrf2 phosphorylation and RSV-induced increase of TJ protein levels and antioxidant gene expression under H2O2 treatment (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Sus scrofa	41-44
31343277-5	2019	The cnidium lactone-induced osteoclastogenesis was significantly attenuated by inhibition of p38 and PI3K through pretreatment with SB203580 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	mitogen-activated protein kinase 14	Mus musculus	93-96
31343277-6	2019	Furthermore, cnidium lactone inhibited the expression of c-Fos and NFATc-1 with dose-dependently and enhanced by SB203580 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	FBJ osteosarcoma oncogene	Mus musculus	57-62
31343277-6	2019	Furthermore, cnidium lactone inhibited the expression of c-Fos and NFATc-1 with dose-dependently and enhanced by SB203580 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	67-74
31829201-4	2019	Under the simulation of TNF-alpha, with or without PI3K/Akt inhibitor LY294002, Cadherin-11 expression was detected by real-time PCR and Western blot, as well as the migration and invasive capacity changes of OA FLS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	thymoma viral proto-oncogene 1	Mus musculus	56-59
31829201-7	2019	PI3K inhibitor LY294002 attenuated TNF-alpha-induced overexpression of Cadherin-11 and decreased the invasive capacity of OA FLS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	tumor necrosis factor	Mus musculus	35-44
31829201-7	2019	PI3K inhibitor LY294002 attenuated TNF-alpha-induced overexpression of Cadherin-11 and decreased the invasive capacity of OA FLS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cadherin 11	Mus musculus	71-82
31829201-8	2019	Intraperitoneal injection of PI3K inhibitor LY294002 could decrease the Cadherin-11 protein expression in synovium of CIOA mice, although it has no significant inhibitory effect on synovitis and cartilage damage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	cadherin 11	Mus musculus	72-83
31806860-13	2019	The expression of p-PI3K, p-AKT, and p-mTOR in LPS+LY294002 was reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
31806860-13	2019	The expression of p-PI3K, p-AKT, and p-mTOR in LPS+LY294002 was reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	mechanistic target of rapamycin kinase	Rattus norvegicus	39-43
31885790-7	2019	Moreover, blocking AKT with the PI3K/AKT inhibitor LY294002 or knocking down AKT via RNA interference significantly decreased PBX1 expression, while increasing p16 and p21 expression and the number of SA-beta-gal-positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	19-22
31885790-7	2019	Moreover, blocking AKT with the PI3K/AKT inhibitor LY294002 or knocking down AKT via RNA interference significantly decreased PBX1 expression, while increasing p16 and p21 expression and the number of SA-beta-gal-positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	37-40
31885790-7	2019	Moreover, blocking AKT with the PI3K/AKT inhibitor LY294002 or knocking down AKT via RNA interference significantly decreased PBX1 expression, while increasing p16 and p21 expression and the number of SA-beta-gal-positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	37-40
31885790-7	2019	Moreover, blocking AKT with the PI3K/AKT inhibitor LY294002 or knocking down AKT via RNA interference significantly decreased PBX1 expression, while increasing p16 and p21 expression and the number of SA-beta-gal-positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	PBX homeobox 1	Homo sapiens	126-130
31885790-7	2019	Moreover, blocking AKT with the PI3K/AKT inhibitor LY294002 or knocking down AKT via RNA interference significantly decreased PBX1 expression, while increasing p16 and p21 expression and the number of SA-beta-gal-positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	cyclin dependent kinase inhibitor 2A	Homo sapiens	160-163
31885790-7	2019	Moreover, blocking AKT with the PI3K/AKT inhibitor LY294002 or knocking down AKT via RNA interference significantly decreased PBX1 expression, while increasing p16 and p21 expression and the number of SA-beta-gal-positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	H3 histone pseudogene 16	Homo sapiens	168-171
31885790-7	2019	Moreover, blocking AKT with the PI3K/AKT inhibitor LY294002 or knocking down AKT via RNA interference significantly decreased PBX1 expression, while increasing p16 and p21 expression and the number of SA-beta-gal-positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	SH3 domain binding protein 5	Homo sapiens	201-208
31159591-5	2019	LY294002 and Compound C were used to treat H9c2 cells for blocking PI3K/AKT and AMPK pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
31159591-5	2019	LY294002 and Compound C were used to treat H9c2 cells for blocking PI3K/AKT and AMPK pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	80-84
31159591-10	2019	The protective effects of ghrelin against H/R-induced cell damage were all attenuated by the addition of LY294002 or Compound C. Moreover, endogenous inhibition of ghrelin significantly induced cell death of H9c2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	ghrelin and obestatin prepropeptide	Rattus norvegicus	26-33
31159591-10	2019	The protective effects of ghrelin against H/R-induced cell damage were all attenuated by the addition of LY294002 or Compound C. Moreover, endogenous inhibition of ghrelin significantly induced cell death of H9c2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	ghrelin and obestatin prepropeptide	Rattus norvegicus	164-171
31642978-10	2019	PI3K and p-Akt were much higher after insulin exposure and the compromised decidualization by high insulin treatment was rescued by PI3K/Akt inhibitor LY294002 both in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	insulin	Homo sapiens	38-45
31642978-10	2019	PI3K and p-Akt were much higher after insulin exposure and the compromised decidualization by high insulin treatment was rescued by PI3K/Akt inhibitor LY294002 both in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	insulin	Homo sapiens	99-106
31642978-10	2019	PI3K and p-Akt were much higher after insulin exposure and the compromised decidualization by high insulin treatment was rescued by PI3K/Akt inhibitor LY294002 both in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	thymoma viral proto-oncogene 1	Mus musculus	137-140
31544532-9	2019	Furthermore, rrOPN promoted the expression of p-STAT3 and p-AKT, while OPN-Ab and PI3K/Akt inhibitor LY294002 both inhibited the expressions of p-AKT and Bcl2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Rattus norvegicus	146-149
31544532-9	2019	Furthermore, rrOPN promoted the expression of p-STAT3 and p-AKT, while OPN-Ab and PI3K/Akt inhibitor LY294002 both inhibited the expressions of p-AKT and Bcl2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	BCL2, apoptosis regulator	Rattus norvegicus	154-158
31642978-10	2019	PI3K and p-Akt were much higher after insulin exposure and the compromised decidualization by high insulin treatment was rescued by PI3K/Akt inhibitor LY294002 both in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	thymoma viral proto-oncogene 1	Mus musculus	11-14
31586450-11	2019	In addition, application of the PI3K/Akt antagonist LY294002 counteracted the effect of G-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	thymoma viral proto-oncogene 1	Mus musculus	37-40
31473257-6	2019	Furthermore, we identified that the up-regulation of COX-2 in JMJD8 knockdown cells was partially due to the increased activation of AKT/NF-kappaB signaling, and LY294002 (an inhibitor of the PI3K/AKT signaling pathway) repressed the induction of COX-2 and Ku70/Ku80.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-58
31473257-6	2019	Furthermore, we identified that the up-regulation of COX-2 in JMJD8 knockdown cells was partially due to the increased activation of AKT/NF-kappaB signaling, and LY294002 (an inhibitor of the PI3K/AKT signaling pathway) repressed the induction of COX-2 and Ku70/Ku80.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	jumonji domain containing 8	Homo sapiens	62-67
31502193-8	2019	Furthermore, cotreatment with PTP1B inhibitor significantly decreased the number of apoptotic CMECs induced by Ang II, along with increased PI3K expression, phosphorylation of Akt and the ratio of Bcl-2/Bax, decreased caspase-3 activity, and a cleaved caspase-3/caspase-3 ratio, while treatment with LY294002 partly inhibited the anti-apoptotic effect of the PTP1B inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	300-308	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	30-35
31654751-6	2019	It was also found that blocking PI3K/AKT pathway by LY294002, abolished the protection of H2S against scratch-induced cellular reactive oxygen species level and NRF2 accumulation and function in the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Rattus norvegicus	37-40
31267530-11	2019	The VEGFA-induced migration of hDPSCs was significantly inhibited with drug inhibitors such as PF573228, LY294002, SB203580 or SU5416 (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	vascular endothelial growth factor A	Homo sapiens	4-9
31654751-6	2019	It was also found that blocking PI3K/AKT pathway by LY294002, abolished the protection of H2S against scratch-induced cellular reactive oxygen species level and NRF2 accumulation and function in the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	NFE2 like bZIP transcription factor 2	Rattus norvegicus	161-165
30471105-8	2019	Inhibitor AG1024 and LY294002 significantly inhibited ECM synthesis and the phosphorylation of IGF-1R, PI3K, and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	insulin like growth factor 1 receptor	Homo sapiens	95-101
31576676-8	2019	LY294002 and imatinib were used to inhibit the activity of PI3K/Akt and platelet-derived growth factor receptor (PDGFR) beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	64-67
31576676-8	2019	LY294002 and imatinib were used to inhibit the activity of PI3K/Akt and platelet-derived growth factor receptor (PDGFR) beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	platelet derived growth factor receptor beta	Homo sapiens	113-124
30684191-8	2019	Inhibition of MAPK by U0126 and PI3K by LY294002 led to concomitant decrease in the HGF-mediated migration/invasion of HTR-8/SVneo cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	hepatocyte growth factor	Homo sapiens	84-87
30471105-8	2019	Inhibitor AG1024 and LY294002 significantly inhibited ECM synthesis and the phosphorylation of IGF-1R, PI3K, and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	113-116
31148200-5	2019	Furthermore, real-time quantitative polymerase chain reaction indicated that the PI3K inhibitor LY294002 blocked the messenger RNA (mRNA) levels of MCP-1 (CCL-2), the MEK1/2 inhibitor U0126 reduced the mRNA levels of TNF-alpha and MCP-1 (CCL-2), and the JNK1/2/3 inhibitor SP600125 prevented the upregulation of inducible nitric oxide synthase mRNA in rFIP-glu-induced cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	chemokine (C-C motif) ligand 2	Mus musculus	148-153
31120592-6	2019	The PTEN/AKT pathway-related proteins and their roles in miR-92b-3p regulation were also identified using western blotting and immunofluorescence in vitro through LY294002, an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	phosphatase and tensin homolog	Rattus norvegicus	4-8
31120592-6	2019	The PTEN/AKT pathway-related proteins and their roles in miR-92b-3p regulation were also identified using western blotting and immunofluorescence in vitro through LY294002, an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	AKT serine/threonine kinase 1	Rattus norvegicus	9-12
31120592-10	2019	Furthermore, the dual-luciferase reporter assay revealed that miR-92b-3p exerted its effect by targeting PTEN"s 3"-untranslated regions and that this effect could be counteracted by AKT phosphorylation blocker LY294002 through western blotting and immunofluorescence.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	microRNA 9-2	Rattus norvegicus	62-71
31120592-10	2019	Furthermore, the dual-luciferase reporter assay revealed that miR-92b-3p exerted its effect by targeting PTEN"s 3"-untranslated regions and that this effect could be counteracted by AKT phosphorylation blocker LY294002 through western blotting and immunofluorescence.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	phosphatase and tensin homolog	Rattus norvegicus	105-109
31120592-10	2019	Furthermore, the dual-luciferase reporter assay revealed that miR-92b-3p exerted its effect by targeting PTEN"s 3"-untranslated regions and that this effect could be counteracted by AKT phosphorylation blocker LY294002 through western blotting and immunofluorescence.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	AKT serine/threonine kinase 1	Rattus norvegicus	182-185
31148200-5	2019	Furthermore, real-time quantitative polymerase chain reaction indicated that the PI3K inhibitor LY294002 blocked the messenger RNA (mRNA) levels of MCP-1 (CCL-2), the MEK1/2 inhibitor U0126 reduced the mRNA levels of TNF-alpha and MCP-1 (CCL-2), and the JNK1/2/3 inhibitor SP600125 prevented the upregulation of inducible nitric oxide synthase mRNA in rFIP-glu-induced cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	chemokine (C-C motif) ligand 2	Mus musculus	155-160
31638199-8	2019	LY294002 further enhanced Ang II-induced downregulation of Akt and p65 NF-kappaB activation, as well as upregulation of caspase-9 mRNA and protein, and promoted the apoptosis of podocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	26-32
31590996-5	2019	LY294002 was injected intracerebroventricularly to selectively inhibit PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	76-79
31590996-10	2019	Propofol significantly upregulates the immunoreactivity of p-Akt, Nrf2, and NQO1, all of which were abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
31590996-10	2019	Propofol significantly upregulates the immunoreactivity of p-Akt, Nrf2, and NQO1, all of which were abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	NFE2 like bZIP transcription factor 2	Rattus norvegicus	66-70
31590996-10	2019	Propofol significantly upregulates the immunoreactivity of p-Akt, Nrf2, and NQO1, all of which were abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	76-80
31590996-11	2019	Propofol significantly downregulates the overexpression of NF-kappaB p65, COX-2, TNF-alpha, and IL-1beta, all of which were inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	74-79
31590996-11	2019	Propofol significantly downregulates the overexpression of NF-kappaB p65, COX-2, TNF-alpha, and IL-1beta, all of which were inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	tumor necrosis factor	Rattus norvegicus	81-90
31590996-11	2019	Propofol significantly downregulates the overexpression of NF-kappaB p65, COX-2, TNF-alpha, and IL-1beta, all of which were inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	interleukin 1 alpha	Rattus norvegicus	96-104
31448474-8	2019	Furthermore, LY294002, a specific inhibitor of PI3K/Akt pathway, attenuated the activation of NK-kappaB and osteogenic differentiation of HASMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	52-55
31629029-12	2019	Moreover, the protective effects of Rb1 against MGO-induced apoptosis were partly abolished by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	RB transcriptional corepressor 1	Homo sapiens	36-39
31638199-5	2019	Cells were treated with 10-6 mol/l of Ang II and/or LY294002 (inhibitor of Akt) or 740Y-P (activator of PI3K) for 48 h to detect Akt, phosphorylated (phospho)-Akt, p65 NF-kappaB, and phospho-p65 NF-kappaB, nephrin, podocin and caspase-9 expression, and podocyte apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	thymoma viral proto-oncogene 1	Mus musculus	75-78
31570770-10	2019	Notably, LY294002, a PI3K inhibitor, or knockdown of PI3K by small interfering RNA significantly suppressed Akt phosphorylation, attenuated HO-1 induction, and further reversed these beneficial effects evoked by hemin pretreatment in RAW264.7 cells or rats received LPS, indicating a direct involvement of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	thymoma viral proto-oncogene 1	Mus musculus	108-111
31570770-10	2019	Notably, LY294002, a PI3K inhibitor, or knockdown of PI3K by small interfering RNA significantly suppressed Akt phosphorylation, attenuated HO-1 induction, and further reversed these beneficial effects evoked by hemin pretreatment in RAW264.7 cells or rats received LPS, indicating a direct involvement of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	heme oxygenase 1	Mus musculus	140-144
31570770-10	2019	Notably, LY294002, a PI3K inhibitor, or knockdown of PI3K by small interfering RNA significantly suppressed Akt phosphorylation, attenuated HO-1 induction, and further reversed these beneficial effects evoked by hemin pretreatment in RAW264.7 cells or rats received LPS, indicating a direct involvement of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Rattus norvegicus	311-314
31638199-8	2019	LY294002 further enhanced Ang II-induced downregulation of Akt and p65 NF-kappaB activation, as well as upregulation of caspase-9 mRNA and protein, and promoted the apoptosis of podocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	59-62
31638199-8	2019	LY294002 further enhanced Ang II-induced downregulation of Akt and p65 NF-kappaB activation, as well as upregulation of caspase-9 mRNA and protein, and promoted the apoptosis of podocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	67-80
31638199-8	2019	LY294002 further enhanced Ang II-induced downregulation of Akt and p65 NF-kappaB activation, as well as upregulation of caspase-9 mRNA and protein, and promoted the apoptosis of podocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 9	Mus musculus	120-129
31807174-8	2019	Furthermore, western blot analysis confirmed that blocking the function of PI3K/Akt and ERK with LY294002 and U0126 resulted in upregulation of E-cadherin expression, and downregulation of vimentin and Snail expression in EGF- and TGF-beta1-treated HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	80-83
31807174-8	2019	Furthermore, western blot analysis confirmed that blocking the function of PI3K/Akt and ERK with LY294002 and U0126 resulted in upregulation of E-cadherin expression, and downregulation of vimentin and Snail expression in EGF- and TGF-beta1-treated HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	mitogen-activated protein kinase 1	Homo sapiens	88-91
31807174-8	2019	Furthermore, western blot analysis confirmed that blocking the function of PI3K/Akt and ERK with LY294002 and U0126 resulted in upregulation of E-cadherin expression, and downregulation of vimentin and Snail expression in EGF- and TGF-beta1-treated HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	cadherin 1	Homo sapiens	144-154
31807174-8	2019	Furthermore, western blot analysis confirmed that blocking the function of PI3K/Akt and ERK with LY294002 and U0126 resulted in upregulation of E-cadherin expression, and downregulation of vimentin and Snail expression in EGF- and TGF-beta1-treated HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	snail family transcriptional repressor 1	Homo sapiens	202-207
31807174-8	2019	Furthermore, western blot analysis confirmed that blocking the function of PI3K/Akt and ERK with LY294002 and U0126 resulted in upregulation of E-cadherin expression, and downregulation of vimentin and Snail expression in EGF- and TGF-beta1-treated HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	epidermal growth factor	Homo sapiens	222-225
31807174-8	2019	Furthermore, western blot analysis confirmed that blocking the function of PI3K/Akt and ERK with LY294002 and U0126 resulted in upregulation of E-cadherin expression, and downregulation of vimentin and Snail expression in EGF- and TGF-beta1-treated HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	transforming growth factor beta 1	Homo sapiens	231-240
31894002-5	2019	The AKT pathway inhibitor LY294002 (50 mumol/L) was used for investigating the role of AKT pathway in the autophagy in RAW264.7 cells treated by oxLDL/beta2GPI/anti-beta2GPI antibody complex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	thymoma viral proto-oncogene 1	Mus musculus	4-7
31849609-7	2019	Treating neurons with either rapamycin to inhibit the mTOR or LY294002 to inhibit the PI3K/Akt activity rescued the morphological abnormalities resulting from either NL3 knockdown or knockout (KO).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	neuroligin 3	Rattus norvegicus	166-169
31658358-6	2019	Importantly, the enhanced PI3K, Akt, mTOR and S6K expression by miR-365 inhibitor (anti-miR-365) was abrogated by treatment with LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	AKT serine/threonine kinase 1	Homo sapiens	32-35
31658358-6	2019	Importantly, the enhanced PI3K, Akt, mTOR and S6K expression by miR-365 inhibitor (anti-miR-365) was abrogated by treatment with LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	mechanistic target of rapamycin kinase	Homo sapiens	37-41
31658358-6	2019	Importantly, the enhanced PI3K, Akt, mTOR and S6K expression by miR-365 inhibitor (anti-miR-365) was abrogated by treatment with LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	ribosomal protein S6 kinase B1	Homo sapiens	46-49
31606200-7	2019	Mechanism studies demonstrated that TSH promoted AKT phosphorylation (P<0.05), and that LY294002 inhibited the reduction of eNOS expression by TSH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	nitric oxide synthase 3	Homo sapiens	124-128
31723054-14	2019	Furthermore, the Akt agonist, insulin-like growth factor-1 (IGF-1), prevented I/R injury in TSLPR-/- mice and an Akt inhibitor, LY294002, blocked the protective effects of TSLP in WT mice subjected to I/R.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	thymoma viral proto-oncogene 1	Mus musculus	113-116
31684995-10	2019	When we stimulated HCC cells with exogenous IL-8, cell invasion and the levels of integrin beta3, p-PI3K, and p-Akt increased, which could be effectively reversed by adding PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	AKT serine/threonine kinase 1	Homo sapiens	112-115
31885775-4	2019	These effects were suppressed by LY294002, an inhibitor of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Homo sapiens	68-71
31747880-10	2019	Furthermore, either 1G6-D7 or PI3K inhibitor LY294002 suppressed the significant phosphorylation of AKT, which caused by secreted and recombinant Hsp90alpha, resulting in the restoration of epithelial barrier function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	100-103
31747880-10	2019	Furthermore, either 1G6-D7 or PI3K inhibitor LY294002 suppressed the significant phosphorylation of AKT, which caused by secreted and recombinant Hsp90alpha, resulting in the restoration of epithelial barrier function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	heat shock protein 90 alpha family class A member 1	Homo sapiens	146-156
31376806-6	2019	Blockage of the PI3K/AKT pathway with its inhibitor LY294002 eliminated the inhibitory effect of CLU on Cr(VI)-induced premature senescence.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	21-24
31376806-6	2019	Blockage of the PI3K/AKT pathway with its inhibitor LY294002 eliminated the inhibitory effect of CLU on Cr(VI)-induced premature senescence.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	clusterin	Homo sapiens	97-100
31827702-7	2019	Cotreatment with the autophagy inhibitor (3-methyladenine, LY294002, or chloroquine) resulted in a significant enhancement of quercetin-induced BAK activation and subsequently the mitochondrial damage-mediated apoptosis pathway by augmenting the downregulation of BAG3 and MCL-1 levels in J/Neo cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	BAG cochaperone 3	Homo sapiens	264-268
31827702-7	2019	Cotreatment with the autophagy inhibitor (3-methyladenine, LY294002, or chloroquine) resulted in a significant enhancement of quercetin-induced BAK activation and subsequently the mitochondrial damage-mediated apoptosis pathway by augmenting the downregulation of BAG3 and MCL-1 levels in J/Neo cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	273-278
31713091-7	2019	Inhibition of protein kinase A (PKA), protein kinase C (PKC) and, Ca2+/calmodulin-dependent protein kinase II (CaMKII), but not phosphoinositide 3-kinase(PI3K), by using the pharmacological the inhibitors: H-89, chelerythrine, KN-62, and LY294002, respectively totally abolished the cytoprotective effects of UA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	238-246	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	111-117
31719796-9	2019	In addition, an AKT inhibitor LY294002 was used to determine the connection between TRIM27 and AKT in ESCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	16-19
31719796-9	2019	In addition, an AKT inhibitor LY294002 was used to determine the connection between TRIM27 and AKT in ESCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	tripartite motif containing 27	Homo sapiens	84-90
31719796-9	2019	In addition, an AKT inhibitor LY294002 was used to determine the connection between TRIM27 and AKT in ESCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	95-98
31719797-10	2019	Further, LY294002, a specific AKT inhibitor, was utilized to examine the connection between TRIM11 and AKT in human chordoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	30-33
31684995-10	2019	When we stimulated HCC cells with exogenous IL-8, cell invasion and the levels of integrin beta3, p-PI3K, and p-Akt increased, which could be effectively reversed by adding PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
31684995-10	2019	When we stimulated HCC cells with exogenous IL-8, cell invasion and the levels of integrin beta3, p-PI3K, and p-Akt increased, which could be effectively reversed by adding PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	integrin subunit beta 3	Homo sapiens	82-96
31302247-7	2019	Mechanically, LGALS3BP regulated OSCC proliferation and migration via PI3K/AKT pathways, which was abrogated by PI3K inhibitor LY294002 in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	galectin 3 binding protein	Homo sapiens	14-22
31759362-0	2019	The Role of the LY294002 - A Non-Selective Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) Pathway- in Cell Survival and Proliferation in Cell Line SCC-25.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	56-85
31369731-7	2019	Using pharmacological treatments, our data further reveal that the activation of ERK1/2 (PD184352), CaMKII (KN-62) and PI3K (LY294002; 740 Y-P) is involved in the NMDA-induced AVP gene expression in the PVN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	mitogen activated protein kinase 3	Rattus norvegicus	81-87
31369731-7	2019	Using pharmacological treatments, our data further reveal that the activation of ERK1/2 (PD184352), CaMKII (KN-62) and PI3K (LY294002; 740 Y-P) is involved in the NMDA-induced AVP gene expression in the PVN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	arginine vasopressin	Rattus norvegicus	176-179
31302247-7	2019	Mechanically, LGALS3BP regulated OSCC proliferation and migration via PI3K/AKT pathways, which was abrogated by PI3K inhibitor LY294002 in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	75-78
31563029-7	2019	Additionally, a marked decrease in c-fos expression was also observed in the larvae group exposed to LY294002 in comparison to control.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	35-40
31807064-9	2019	The results also demonstrated that the overexpression of CLDN12 increased the activation of Thr308 site in Akt in fetal osteoblast cells, and the PI3K inhibitor LY294002 partially decreased CLDN12-promoted proliferation and metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	claudin 12	Homo sapiens	57-63
31807064-9	2019	The results also demonstrated that the overexpression of CLDN12 increased the activation of Thr308 site in Akt in fetal osteoblast cells, and the PI3K inhibitor LY294002 partially decreased CLDN12-promoted proliferation and metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	AKT serine/threonine kinase 1	Homo sapiens	107-110
31807064-9	2019	The results also demonstrated that the overexpression of CLDN12 increased the activation of Thr308 site in Akt in fetal osteoblast cells, and the PI3K inhibitor LY294002 partially decreased CLDN12-promoted proliferation and metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	claudin 12	Homo sapiens	190-196
31260867-9	2019	In addition, the inhibition of AKT with a pharmacological inhibitor (LY294002) demonstrated more synergic anti-proliferative effects than in the TM3 and TM4 cell lines treated only with alpha-solanine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	thymoma viral proto-oncogene 1	Mus musculus	31-34
31545483-8	2019	In cultured HCAECs, IGFBP1 was shown to protect ECs against passage- or H2O2-induced senescence, and these protective effects of IGFBP1 may be partially reversed by LY294002, a known Akt signaling inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	insulin like growth factor binding protein 1	Homo sapiens	20-26
31602203-12	2019	Adropin significantly increased the phosphorylation of Akt, ERK1/2 and GSK3beta, whereas inhibitors of PI3K and ERK1/2, respectively, LY294002 and PD98059, abolished the cardioprotective role of adropin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	mitogen activated protein kinase 3	Rattus norvegicus	112-118
31466050-5	2019	PI3K/AKT signaling was inhibited using LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	5-8
31545483-8	2019	In cultured HCAECs, IGFBP1 was shown to protect ECs against passage- or H2O2-induced senescence, and these protective effects of IGFBP1 may be partially reversed by LY294002, a known Akt signaling inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	insulin like growth factor binding protein 1	Homo sapiens	129-135
31545483-8	2019	In cultured HCAECs, IGFBP1 was shown to protect ECs against passage- or H2O2-induced senescence, and these protective effects of IGFBP1 may be partially reversed by LY294002, a known Akt signaling inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	AKT serine/threonine kinase 1	Homo sapiens	183-186
31076999-8	2019	NGN activated both ERK and PI3 K/Akt, and treatments with the specific ERK inhibitor PD98059, the PI3 K inhibitor LY294002, and the specific Nrf2 shRNA suppressed the NGN-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	mitogen-activated protein kinase 1	Homo sapiens	19-22
30989663-9	2019	Furthermore, our data proved that the promoting effects of G3BP1-overexpression on cell proliferation, migration, and invasion could be rescued by PI3K inhibitor LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	G3BP stress granule assembly factor 1	Homo sapiens	59-64
31342299-6	2019	Akt inhibition (by LY294002 and MK-2206) or CRISPR-Cas9-mediated Akt1 knockout completely abolished SC79-induced DA neuroprotection against MPP+.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	0-3
31076999-8	2019	NGN activated both ERK and PI3 K/Akt, and treatments with the specific ERK inhibitor PD98059, the PI3 K inhibitor LY294002, and the specific Nrf2 shRNA suppressed the NGN-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	heme oxygenase 1	Homo sapiens	179-183
31636329-8	2019	The reduced corticosteroid responsiveness may be mediated by glycolytic reprogramming, specifically glycolysis-associated PI3K signaling, as PI3K inhibitor LY294002 restored the sensitivity of CXCL8 secretion to corticosteroids in A549 Rho-0 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	C-X-C motif chemokine ligand 8	Homo sapiens	193-198
31610196-6	2019	The increasing expression of pAKT, pGSK3beta and beta-catenin induced by Dex was markedly inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	catenin beta 1	Rattus norvegicus	49-61
31872599-14	2019	LY294002 also induced a further inhibition of expression of AKT and p-AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	60-63
31872599-14	2019	LY294002 also induced a further inhibition of expression of AKT and p-AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	70-73
31493869-7	2019	Lastly, REDD1 depletion activates Akt/mTORC1 pathway following OGD/R treatment, and inhibition of this pathway using both LY294002 and rapamycin abrogates REDD1 effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	DNA-damage-inducible transcript 4	Rattus norvegicus	155-160
31802891-13	2019	LY294002, a PI3K inhibitor, could eliminate the NCAPG role of promoting HCC cell proliferation and reducing HCC cell apoptosis, while 740Y-P, a PI3K activator, contributed to the opposite effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	non-SMC condensin I complex subunit G	Homo sapiens	48-53
31680984-7	2019	The inhibition of the PI3K/Akt pathway by the specific inhibitor LY294002 partially reversed the therapeutic effects of FGF10 both in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	27-30
31680984-7	2019	The inhibition of the PI3K/Akt pathway by the specific inhibitor LY294002 partially reversed the therapeutic effects of FGF10 both in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	fibroblast growth factor 10	Homo sapiens	120-125
31461309-5	2019	Mechanical paw withdrawal threshold and paw withdrawal latency significantly decreased after sciatic endometriosis induction in rats; this decrease was ameliorated by inhibiting the PI3K/Akt/mTOR signaling pathway using LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	AKT serine/threonine kinase 1	Rattus norvegicus	187-190
31381959-8	2019	Furthermore, the addition of Janus kinase 2 (JAK2) inhibitor CEP-33779 or phosphoinositide 3-kinase (PI3K) inhibitor LY294002 to the culture medium also blocked the nuclear translocation of p-p65, the expression of GDF10, and axonal sprouting, suggesting that EPO induces axonal sprouting via activating cellular JAK2 and PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	growth differentiation factor 10	Homo sapiens	215-220
31381959-8	2019	Furthermore, the addition of Janus kinase 2 (JAK2) inhibitor CEP-33779 or phosphoinositide 3-kinase (PI3K) inhibitor LY294002 to the culture medium also blocked the nuclear translocation of p-p65, the expression of GDF10, and axonal sprouting, suggesting that EPO induces axonal sprouting via activating cellular JAK2 and PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	erythropoietin	Homo sapiens	260-263
31381959-8	2019	Furthermore, the addition of Janus kinase 2 (JAK2) inhibitor CEP-33779 or phosphoinositide 3-kinase (PI3K) inhibitor LY294002 to the culture medium also blocked the nuclear translocation of p-p65, the expression of GDF10, and axonal sprouting, suggesting that EPO induces axonal sprouting via activating cellular JAK2 and PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	Janus kinase 2	Homo sapiens	313-317
31176760-12	2019	Finally, we found naringenin promoted AKT phosphorylation; PI3K inhibitor LY294002 treatment increased nuclear ATF6 and reduced naringenin-enhanced ABCA1 expression and cholesterol efflux.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	thymoma viral proto-oncogene 1	Mus musculus	38-41
31176760-12	2019	Finally, we found naringenin promoted AKT phosphorylation; PI3K inhibitor LY294002 treatment increased nuclear ATF6 and reduced naringenin-enhanced ABCA1 expression and cholesterol efflux.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	activating transcription factor 6	Mus musculus	111-115
31176760-12	2019	Finally, we found naringenin promoted AKT phosphorylation; PI3K inhibitor LY294002 treatment increased nuclear ATF6 and reduced naringenin-enhanced ABCA1 expression and cholesterol efflux.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	148-153
31570094-5	2019	Additionally, consistent with enhanced expression of PI3K-AMPAR GluR2 subunit complex substances in ipsilateral hippocampus, GluR2 subunits showed increased levels in both the plasma and postsynaptic membranes of neurons, while pGluR2 expression was reduced in group P. Furthermore, LY294002, the PI3K non-selective antagonist, blocked those effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	283-291	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	53-69
31570094-5	2019	Additionally, consistent with enhanced expression of PI3K-AMPAR GluR2 subunit complex substances in ipsilateral hippocampus, GluR2 subunits showed increased levels in both the plasma and postsynaptic membranes of neurons, while pGluR2 expression was reduced in group P. Furthermore, LY294002, the PI3K non-selective antagonist, blocked those effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	283-291	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	64-69
31737172-17	2019	Meanwhile, there were increases in both UV-induced apoptotic cells and ROS level accompanied with SOD and GPX decrease in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	peroxiredoxin 6 pseudogene 2	Mus musculus	106-109
31377156-6	2019	Inhibition of ERK1/2 or PI-3K/Akt by PD98059 and LY294002 restored the decreased tyrosinase activity and MITF expression via resveratrol-mediated down-regulation of COX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mitogen-activated protein kinase 3	Danio rerio	14-20
31377156-6	2019	Inhibition of ERK1/2 or PI-3K/Akt by PD98059 and LY294002 restored the decreased tyrosinase activity and MITF expression via resveratrol-mediated down-regulation of COX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	thymoma viral proto-oncogene 1	Mus musculus	30-33
31377156-6	2019	Inhibition of ERK1/2 or PI-3K/Akt by PD98059 and LY294002 restored the decreased tyrosinase activity and MITF expression via resveratrol-mediated down-regulation of COX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	tyrosinase	Mus musculus	81-91
31377156-6	2019	Inhibition of ERK1/2 or PI-3K/Akt by PD98059 and LY294002 restored the decreased tyrosinase activity and MITF expression via resveratrol-mediated down-regulation of COX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	melanogenesis associated transcription factor	Mus musculus	105-109
31377156-6	2019	Inhibition of ERK1/2 or PI-3K/Akt by PD98059 and LY294002 restored the decreased tyrosinase activity and MITF expression via resveratrol-mediated down-regulation of COX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	cytochrome c oxidase II, mitochondrial	Danio rerio	165-170
31637210-9	2019	The addition of the PI3K/AKT pathway inhibitor LY294002 to SERPIND1-overexpressing cells could reverse the promoting effect of SERPIND1 on the malignant biological behavior of ovarian cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	25-28
31637210-9	2019	The addition of the PI3K/AKT pathway inhibitor LY294002 to SERPIND1-overexpressing cells could reverse the promoting effect of SERPIND1 on the malignant biological behavior of ovarian cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	serpin family D member 1	Homo sapiens	59-67
31637210-9	2019	The addition of the PI3K/AKT pathway inhibitor LY294002 to SERPIND1-overexpressing cells could reverse the promoting effect of SERPIND1 on the malignant biological behavior of ovarian cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	serpin family D member 1	Homo sapiens	127-135
31243899-7	2019	This promotion of fibrosis by FSH occurred through the activation of AKT/GSK-3beta/beta-catenin pathway, which could be attenuated by silencing FSHR by siRNA or by LY294002 or MK2206.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	AKT serine/threonine kinase 1	Homo sapiens	69-72
31243899-7	2019	This promotion of fibrosis by FSH occurred through the activation of AKT/GSK-3beta/beta-catenin pathway, which could be attenuated by silencing FSHR by siRNA or by LY294002 or MK2206.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	glycogen synthase kinase 3 beta	Homo sapiens	73-82
31243899-7	2019	This promotion of fibrosis by FSH occurred through the activation of AKT/GSK-3beta/beta-catenin pathway, which could be attenuated by silencing FSHR by siRNA or by LY294002 or MK2206.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	catenin beta 1	Homo sapiens	83-95
31461309-5	2019	Mechanical paw withdrawal threshold and paw withdrawal latency significantly decreased after sciatic endometriosis induction in rats; this decrease was ameliorated by inhibiting the PI3K/Akt/mTOR signaling pathway using LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	mechanistic target of rapamycin kinase	Rattus norvegicus	191-195
31461309-8	2019	Following the injection of LY294002 into rats with sciatic endometriosis, there was a significant decrease in the expressions of NGF, substance P, and CGRP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	nerve growth factor	Rattus norvegicus	129-132
31461309-8	2019	Following the injection of LY294002 into rats with sciatic endometriosis, there was a significant decrease in the expressions of NGF, substance P, and CGRP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	calcitonin-related polypeptide alpha	Rattus norvegicus	151-155
31351365-5	2019	LY294002 (a PI3K inhibitor) and SP600125 (a JNK inhibitor) reduced NG-induced HO-1 expression, whereas BIRB796 (a p38 inhibitor) and PD98059 (an ERK inhibitor) had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heme oxygenase 1	Homo sapiens	78-82
31230155-9	2019	LY294002, a PI3K inhibitor, prevented all these effects of salidroside, including those on NeuN, p-PKB/PKB, Nrf2, HO-1, and pro-inflammatory mediators.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	RNA binding fox-1 homolog 3	Rattus norvegicus	91-95
31230155-9	2019	LY294002, a PI3K inhibitor, prevented all these effects of salidroside, including those on NeuN, p-PKB/PKB, Nrf2, HO-1, and pro-inflammatory mediators.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	108-112
31230155-9	2019	LY294002, a PI3K inhibitor, prevented all these effects of salidroside, including those on NeuN, p-PKB/PKB, Nrf2, HO-1, and pro-inflammatory mediators.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heme oxygenase 1	Rattus norvegicus	114-118
31351365-7	2019	Indeed, the results of our experiments using LY294002 and SP600125 indicated that NG may stimulate Nrf2 through PI3K/Akt and JNK pathway activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103
31209930-10	2019	Notably, LY294002, as an inhibitor of AKT signaling pathway, could significantly weaken the effects of HMGB2 overexpression, which indicated that HMGB2 might promote cell proliferation by activating AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	38-41
31209930-10	2019	Notably, LY294002, as an inhibitor of AKT signaling pathway, could significantly weaken the effects of HMGB2 overexpression, which indicated that HMGB2 might promote cell proliferation by activating AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	high mobility group box 2	Homo sapiens	103-108
31265179-7	2019	Blocking of PI3K by LY294002 clearly decreased its antiapoptotic effect and reduced both Akt and mTOR phosphorylation levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Rattus norvegicus	89-92
31209930-10	2019	Notably, LY294002, as an inhibitor of AKT signaling pathway, could significantly weaken the effects of HMGB2 overexpression, which indicated that HMGB2 might promote cell proliferation by activating AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	high mobility group box 2	Homo sapiens	146-151
31265179-7	2019	Blocking of PI3K by LY294002 clearly decreased its antiapoptotic effect and reduced both Akt and mTOR phosphorylation levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mechanistic target of rapamycin kinase	Rattus norvegicus	97-101
31209930-10	2019	Notably, LY294002, as an inhibitor of AKT signaling pathway, could significantly weaken the effects of HMGB2 overexpression, which indicated that HMGB2 might promote cell proliferation by activating AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	199-202
31551535-5	2019	LY-294002, an inhibitor of phosphatidylinositol 3-kinase, inhibited the phosphorylation of Akt and decreased the expression levels of CLDN1 and CLDN11.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	AKT serine/threonine kinase 1	Homo sapiens	91-94
31807423-8	2019	LY294002 was used to block the activation of PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	50-53
30873585-9	2019	LY294002, the inhibitor of PI3K, confirmed that CXCL5 forested an immunosuppression microenvironment by promoting PD-L1 expression via PI3K/AKT signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	chemokine (C-X-C motif) ligand 5	Mus musculus	48-53
30873585-9	2019	LY294002, the inhibitor of PI3K, confirmed that CXCL5 forested an immunosuppression microenvironment by promoting PD-L1 expression via PI3K/AKT signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CD274 antigen	Mus musculus	114-119
31485669-10	2019	Compared with the control cells, E-cadherin expression was significantly increased in cells treated with NS398 or LY294002, while the expression levels of vimentin, MMP-2, MMP-9, VEGF, p-PI3K, p-AKT, and p-IKK were significantly decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	cadherin 1	Homo sapiens	33-43
31505250-7	2019	The neuroprotective effects of edaravone were reversed by LY294002, a specific phosphatidylinositol 3-kinase (PI3K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	79-108
31611842-11	2019	Furthermore, using Atipamezole and LY294002, we found that dexmedetomidine significantly increased GLT-1 levels in astrocytes via activating alpha2 adrenergic receptor and PI3K/AKT pathway both in vitro and in vivo study.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	solute carrier family 1 member 2	Homo sapiens	99-104
31551535-5	2019	LY-294002, an inhibitor of phosphatidylinositol 3-kinase, inhibited the phosphorylation of Akt and decreased the expression levels of CLDN1 and CLDN11.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	claudin 1	Homo sapiens	134-139
31072420-9	2019	Pretreatment with LY294002 significantly enhanced the ability of MPA to suppress proliferation and to induce apoptosis in the parental and Ishikawa-PR cells via the inhibition of AKT activation and upregulation of PRB transcriptional activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	179-182
31551535-5	2019	LY-294002, an inhibitor of phosphatidylinositol 3-kinase, inhibited the phosphorylation of Akt and decreased the expression levels of CLDN1 and CLDN11.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	claudin 11	Homo sapiens	144-150
31072420-10	2019	However, the PRB transcriptional activity and insensitivity to MPA were irreversible by LY294002 in ARID1A-deficient cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AT-rich interaction domain 1A	Homo sapiens	100-106
31349969-6	2019	In cultured neonatal mouse cardiomyocytes, Apelin (1 mumol/L) restored hypoxia-induced Kir2.1 down-regulation, which was abolished by IP3K inhibitor LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-158	apelin	Mus musculus	43-49
31532760-5	2019	RP105 short-interfering RNA (siRNA) was constructed, and LY294002 was used to inhibit the PI3KA/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	phosphoinositide-3-kinase regulatory subunit 1	Rattus norvegicus	90-95
31532760-5	2019	RP105 short-interfering RNA (siRNA) was constructed, and LY294002 was used to inhibit the PI3KA/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
31349969-6	2019	In cultured neonatal mouse cardiomyocytes, Apelin (1 mumol/L) restored hypoxia-induced Kir2.1 down-regulation, which was abolished by IP3K inhibitor LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-158	potassium inwardly-rectifying channel, subfamily J, member 2	Mus musculus	87-93
31502574-8	2019	However, an AKT inhibitor (LY294002) only effected on MMP9 and p-AKT, not on c-Met.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	12-15
31612149-12	2019	Further studies showed that LY294002, aPI3K inhibitor, abolished the effects of SMSO on GSK-3beta phosphorylation and Nrf2 nuclear translocation as well as the protective effects on pancreatic beta cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	glycogen synthase kinase 3 beta	Rattus norvegicus	88-97
31612149-12	2019	Further studies showed that LY294002, aPI3K inhibitor, abolished the effects of SMSO on GSK-3beta phosphorylation and Nrf2 nuclear translocation as well as the protective effects on pancreatic beta cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	118-122
31505769-9	2019	Furthermore, the Ech A-induced ex vivo expansion of CD34+ cells was inhibited by pretreatment with the Src family inhibitor PP1 and p110delta inhibitor CAL-101; PP1 blocked p110delta upregulation and PI3K/Akt activation, whereas CAL-101 and PI3K/Akt pathway inhibitor LY294002 did not block Src/Lyn activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	268-276	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	17-22
31505769-9	2019	Furthermore, the Ech A-induced ex vivo expansion of CD34+ cells was inhibited by pretreatment with the Src family inhibitor PP1 and p110delta inhibitor CAL-101; PP1 blocked p110delta upregulation and PI3K/Akt activation, whereas CAL-101 and PI3K/Akt pathway inhibitor LY294002 did not block Src/Lyn activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	268-276	CD34 molecule	Homo sapiens	52-56
31505769-9	2019	Furthermore, the Ech A-induced ex vivo expansion of CD34+ cells was inhibited by pretreatment with the Src family inhibitor PP1 and p110delta inhibitor CAL-101; PP1 blocked p110delta upregulation and PI3K/Akt activation, whereas CAL-101 and PI3K/Akt pathway inhibitor LY294002 did not block Src/Lyn activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	268-276	inorganic pyrophosphatase 1	Homo sapiens	124-127
31505769-9	2019	Furthermore, the Ech A-induced ex vivo expansion of CD34+ cells was inhibited by pretreatment with the Src family inhibitor PP1 and p110delta inhibitor CAL-101; PP1 blocked p110delta upregulation and PI3K/Akt activation, whereas CAL-101 and PI3K/Akt pathway inhibitor LY294002 did not block Src/Lyn activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	268-276	inorganic pyrophosphatase 1	Homo sapiens	161-164
31228450-7	2019	LY294002 effectively inhibited the PI3K/AKT/mTOR signaling pathway, repressed cell viability and induced apoptosis in OS cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	40-43
31228450-7	2019	LY294002 effectively inhibited the PI3K/AKT/mTOR signaling pathway, repressed cell viability and induced apoptosis in OS cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	44-48
31483776-5	2019	Cells were treated with the PI3K/Akt pathway inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	33-36
31483776-11	2019	In cells that overexpressed BGN, inhibition of the PI3K/Akt pathway by LY294002 increased the sensitivity of human WERI-Rb-1 retinoblastoma cells to rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	biglycan	Homo sapiens	28-31
31483776-11	2019	In cells that overexpressed BGN, inhibition of the PI3K/Akt pathway by LY294002 increased the sensitivity of human WERI-Rb-1 retinoblastoma cells to rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Homo sapiens	56-59
30882397-10	2019	OA significantly increased Akt phosphorylation and reduced FOXA1 expression in SW579 cells, but only PI3K/Akt inhibitor LY294002 attenuated OA-induced FOXA1 downregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	106-109
30882397-10	2019	OA significantly increased Akt phosphorylation and reduced FOXA1 expression in SW579 cells, but only PI3K/Akt inhibitor LY294002 attenuated OA-induced FOXA1 downregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	forkhead box A1	Homo sapiens	151-156
31348616-12	2019	The phosphorylation of AKT and ERK, as well as the expression of the vascular endothelial growth factor, can be inhibited using the LY294002 and U0126 inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	AKT serine/threonine kinase 1	Homo sapiens	23-26
31348616-12	2019	The phosphorylation of AKT and ERK, as well as the expression of the vascular endothelial growth factor, can be inhibited using the LY294002 and U0126 inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	mitogen-activated protein kinase 1	Homo sapiens	31-34
31348616-12	2019	The phosphorylation of AKT and ERK, as well as the expression of the vascular endothelial growth factor, can be inhibited using the LY294002 and U0126 inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	vascular endothelial growth factor A	Homo sapiens	69-103
31270642-10	2019	This was accompanied by an increase in the phosphorylation of Akt and ERK in third stage cell clusters, which was prevented by the addition of the inhibitors PD98059 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Homo sapiens	62-65
31270642-10	2019	This was accompanied by an increase in the phosphorylation of Akt and ERK in third stage cell clusters, which was prevented by the addition of the inhibitors PD98059 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	mitogen-activated protein kinase 1	Homo sapiens	70-73
31120172-5	2019	In addition, AKT, which is an upstream protein kinase of mTORC1 and is downstream of mTORC2, is inhibited by LY294002 (a phosphatidylinositol 3-kinase inhibitor), but not by rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	thymoma viral proto-oncogene 1	Mus musculus	13-16
31120172-5	2019	In addition, AKT, which is an upstream protein kinase of mTORC1 and is downstream of mTORC2, is inhibited by LY294002 (a phosphatidylinositol 3-kinase inhibitor), but not by rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	CREB regulated transcription coactivator 1	Mus musculus	57-63
31120172-5	2019	In addition, AKT, which is an upstream protein kinase of mTORC1 and is downstream of mTORC2, is inhibited by LY294002 (a phosphatidylinositol 3-kinase inhibitor), but not by rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	CREB regulated transcription coactivator 2	Mus musculus	85-91
31532771-11	2019	Increased cell proliferation by EGFR stimulation was completely abolished by MAPK inhibition with PD98059 or by PI3K inhibition with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	epidermal growth factor receptor	Homo sapiens	32-36
30672370-6	2019	Pre-treatment of spinal neurons with a PI3K inhibitor, LY294002 or mammalian target of rapamycin (mTOR) inhibitor, rapamycin blocked bpV activation of Akt and ribosomal protein S6 activity, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	151-154
30672370-6	2019	Pre-treatment of spinal neurons with a PI3K inhibitor, LY294002 or mammalian target of rapamycin (mTOR) inhibitor, rapamycin blocked bpV activation of Akt and ribosomal protein S6 activity, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	ribosomal protein S6	Homo sapiens	159-179
31489995-11	2019	Moreover, AKT-specific inhibitor LY294002 restored the effect of LINC00462 knockdown on apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Homo sapiens	10-13
31489995-11	2019	Moreover, AKT-specific inhibitor LY294002 restored the effect of LINC00462 knockdown on apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	long intergenic non-protein coding RNA 462	Homo sapiens	65-74
31482900-5	2019	The inhibition of Akt signaling by LY294002 or TrkB activity by K252a eliminated the neuroprotective effects of THSG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	thymoma viral proto-oncogene 1	Mus musculus	18-21
31786865-3	2019	The experimental methods are as follows: (1) The proliferation of HGC-27 cells inhibited by Apatinib and LY294002 was observed by 3-(4,5)-dimethylthiahiazo-(z-y1)-3,5-diphenytetrazoli- umromide (MTT) assay; (2) flow cytometry was adopted to detect the apoptosis of cells after they were treated with drugs and the positive control; (3) different effects of varying concentrations of Apatinib on apoptosis-related genes and proteins, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cysteine-aspartic acid protease (Caspase) 9, were detected via fluorescence quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting (WB), and the effects of different concentrations of Apatinib on the protein expressions of PI3K, phosphorylated (p)-PI3K, Akt and p-Akt were detected by Western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	BCL2 apoptosis regulator	Homo sapiens	433-450
31786865-3	2019	The experimental methods are as follows: (1) The proliferation of HGC-27 cells inhibited by Apatinib and LY294002 was observed by 3-(4,5)-dimethylthiahiazo-(z-y1)-3,5-diphenytetrazoli- umromide (MTT) assay; (2) flow cytometry was adopted to detect the apoptosis of cells after they were treated with drugs and the positive control; (3) different effects of varying concentrations of Apatinib on apoptosis-related genes and proteins, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cysteine-aspartic acid protease (Caspase) 9, were detected via fluorescence quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting (WB), and the effects of different concentrations of Apatinib on the protein expressions of PI3K, phosphorylated (p)-PI3K, Akt and p-Akt were detected by Western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	BCL2 apoptosis regulator	Homo sapiens	452-457
31786865-3	2019	The experimental methods are as follows: (1) The proliferation of HGC-27 cells inhibited by Apatinib and LY294002 was observed by 3-(4,5)-dimethylthiahiazo-(z-y1)-3,5-diphenytetrazoli- umromide (MTT) assay; (2) flow cytometry was adopted to detect the apoptosis of cells after they were treated with drugs and the positive control; (3) different effects of varying concentrations of Apatinib on apoptosis-related genes and proteins, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cysteine-aspartic acid protease (Caspase) 9, were detected via fluorescence quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting (WB), and the effects of different concentrations of Apatinib on the protein expressions of PI3K, phosphorylated (p)-PI3K, Akt and p-Akt were detected by Western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	BCL2 associated X, apoptosis regulator	Homo sapiens	460-486
31786865-3	2019	The experimental methods are as follows: (1) The proliferation of HGC-27 cells inhibited by Apatinib and LY294002 was observed by 3-(4,5)-dimethylthiahiazo-(z-y1)-3,5-diphenytetrazoli- umromide (MTT) assay; (2) flow cytometry was adopted to detect the apoptosis of cells after they were treated with drugs and the positive control; (3) different effects of varying concentrations of Apatinib on apoptosis-related genes and proteins, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cysteine-aspartic acid protease (Caspase) 9, were detected via fluorescence quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting (WB), and the effects of different concentrations of Apatinib on the protein expressions of PI3K, phosphorylated (p)-PI3K, Akt and p-Akt were detected by Western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	BCL2 associated X, apoptosis regulator	Homo sapiens	488-491
31786865-3	2019	The experimental methods are as follows: (1) The proliferation of HGC-27 cells inhibited by Apatinib and LY294002 was observed by 3-(4,5)-dimethylthiahiazo-(z-y1)-3,5-diphenytetrazoli- umromide (MTT) assay; (2) flow cytometry was adopted to detect the apoptosis of cells after they were treated with drugs and the positive control; (3) different effects of varying concentrations of Apatinib on apoptosis-related genes and proteins, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cysteine-aspartic acid protease (Caspase) 9, were detected via fluorescence quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting (WB), and the effects of different concentrations of Apatinib on the protein expressions of PI3K, phosphorylated (p)-PI3K, Akt and p-Akt were detected by Western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	caspase 9	Homo sapiens	530-540
31786865-3	2019	The experimental methods are as follows: (1) The proliferation of HGC-27 cells inhibited by Apatinib and LY294002 was observed by 3-(4,5)-dimethylthiahiazo-(z-y1)-3,5-diphenytetrazoli- umromide (MTT) assay; (2) flow cytometry was adopted to detect the apoptosis of cells after they were treated with drugs and the positive control; (3) different effects of varying concentrations of Apatinib on apoptosis-related genes and proteins, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cysteine-aspartic acid protease (Caspase) 9, were detected via fluorescence quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting (WB), and the effects of different concentrations of Apatinib on the protein expressions of PI3K, phosphorylated (p)-PI3K, Akt and p-Akt were detected by Western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	788-791
31502574-8	2019	However, an AKT inhibitor (LY294002) only effected on MMP9 and p-AKT, not on c-Met.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	matrix metallopeptidase 9	Homo sapiens	54-58
31502574-8	2019	However, an AKT inhibitor (LY294002) only effected on MMP9 and p-AKT, not on c-Met.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	65-68
31786865-3	2019	The experimental methods are as follows: (1) The proliferation of HGC-27 cells inhibited by Apatinib and LY294002 was observed by 3-(4,5)-dimethylthiahiazo-(z-y1)-3,5-diphenytetrazoli- umromide (MTT) assay; (2) flow cytometry was adopted to detect the apoptosis of cells after they were treated with drugs and the positive control; (3) different effects of varying concentrations of Apatinib on apoptosis-related genes and proteins, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cysteine-aspartic acid protease (Caspase) 9, were detected via fluorescence quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting (WB), and the effects of different concentrations of Apatinib on the protein expressions of PI3K, phosphorylated (p)-PI3K, Akt and p-Akt were detected by Western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	798-801
31340168-13	2019	In contrast, inhibition of the PI3K/Akt pathway by LY294002 or glycolysis by 2-deoxyglucose resisted the effect of ALC1 overexpression on cisplatin cytotoxicity in ESCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	36-39
31313516-10	2019	The effects of n-butylidenephthalide on increased IL-10 levels were reversed by LY294002 or S3I-201.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	interleukin 10	Rattus norvegicus	50-55
31313516-11	2019	Furthermore, LY294002 abolished the STAT3 phosphorylation, whereas PI3K activity was not affected following the inhibition of STAT3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	signal transducer and activator of transcription 3	Rattus norvegicus	36-41
31278860-12	2019	The specific inhibitor of PI3K, LY294002 not only inhibited QSYQ induced PI3K/Akt signalling pathway activation, but alleviated its protective effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
31301301-9	2019	Furthermore, the requirement of PI3K-Akt activation for the cardioprotective effect of Lnk was confirmed in rescue experiments using the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	SH2B adaptor protein 3	Mus musculus	87-90
31443676-10	2019	The phosphatidylinositol 3-kinase/AKT inhibitor LY294002 was used to inhibit the phosphorylation and activity of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	34-37
31073648-9	2019	However, when nobiletin was co-administered with LY294002, a PI3K (phosphatidylinositol 3-kinase)/Akt inhibitor, all of the previously mentioned effects were blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
31103617-12	2019	Ghrelin-induced proliferation is associated with the inhibition of G1 arrest, and this inhibition was blocked by LY294002 (specific inhibitor of PI3K, 20 muM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	ghrelin	Mus musculus	0-7
31404628-11	2019	The apoptotic cell death induced by PPVI was confirmed, and it was significantly suppressed by the overexpression of AKT, ERK and mTOR, and the induced autophagic cell death which was depended on the Atg7 was decreased by the inhibitors, such as LY294002 (LY), Bafilomycin A1 (Baf), Compound C (CC) and SBI-0206965 (SBI).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-254	AKT serine/threonine kinase 1	Homo sapiens	117-120
31404628-11	2019	The apoptotic cell death induced by PPVI was confirmed, and it was significantly suppressed by the overexpression of AKT, ERK and mTOR, and the induced autophagic cell death which was depended on the Atg7 was decreased by the inhibitors, such as LY294002 (LY), Bafilomycin A1 (Baf), Compound C (CC) and SBI-0206965 (SBI).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-254	autophagy related 7	Homo sapiens	200-204
31404628-11	2019	The apoptotic cell death induced by PPVI was confirmed, and it was significantly suppressed by the overexpression of AKT, ERK and mTOR, and the induced autophagic cell death which was depended on the Atg7 was decreased by the inhibitors, such as LY294002 (LY), Bafilomycin A1 (Baf), Compound C (CC) and SBI-0206965 (SBI).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-254	BAF nuclear assembly factor 1	Homo sapiens	261-264
31404628-11	2019	The apoptotic cell death induced by PPVI was confirmed, and it was significantly suppressed by the overexpression of AKT, ERK and mTOR, and the induced autophagic cell death which was depended on the Atg7 was decreased by the inhibitors, such as LY294002 (LY), Bafilomycin A1 (Baf), Compound C (CC) and SBI-0206965 (SBI).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-248	AKT serine/threonine kinase 1	Homo sapiens	117-120
31404628-11	2019	The apoptotic cell death induced by PPVI was confirmed, and it was significantly suppressed by the overexpression of AKT, ERK and mTOR, and the induced autophagic cell death which was depended on the Atg7 was decreased by the inhibitors, such as LY294002 (LY), Bafilomycin A1 (Baf), Compound C (CC) and SBI-0206965 (SBI).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-248	autophagy related 7	Homo sapiens	200-204
31404628-11	2019	The apoptotic cell death induced by PPVI was confirmed, and it was significantly suppressed by the overexpression of AKT, ERK and mTOR, and the induced autophagic cell death which was depended on the Atg7 was decreased by the inhibitors, such as LY294002 (LY), Bafilomycin A1 (Baf), Compound C (CC) and SBI-0206965 (SBI).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-248	BAF nuclear assembly factor 1	Homo sapiens	261-264
31602952-17	2019	The protective effect of Shenxiong Glucose Injection on H_2O_2 cells injury was significantly inhibited by LY294002,a PI3 K/AKT pathway inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	AKT serine/threonine kinase 1	Rattus norvegicus	124-127
31497671-4	2019	Proliferation assays indicated that vGPCR cell number decreased in presence of LY294002 (PI3K/Akt inhibitor) likewise 1alpha,25(OH)2D3 or TX 527 (10 nM, 48 h).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	94-97
31240382-8	2019	Finally, we show that the activation of beta-catenin by PGE2 required signaling through the phosphatidylinositol 3-kinase (PI3K)/Akt/glycogen synthase kinase 3 beta (GSK3beta) pathway, as the PI3K inhibitor, LY-294002, disrupted the synergy between connexin43 and PGE2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-217	catenin beta 1	Rattus norvegicus	40-52
31240382-8	2019	Finally, we show that the activation of beta-catenin by PGE2 required signaling through the phosphatidylinositol 3-kinase (PI3K)/Akt/glycogen synthase kinase 3 beta (GSK3beta) pathway, as the PI3K inhibitor, LY-294002, disrupted the synergy between connexin43 and PGE2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-217	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	92-121
31240382-8	2019	Finally, we show that the activation of beta-catenin by PGE2 required signaling through the phosphatidylinositol 3-kinase (PI3K)/Akt/glycogen synthase kinase 3 beta (GSK3beta) pathway, as the PI3K inhibitor, LY-294002, disrupted the synergy between connexin43 and PGE2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-217	AKT serine/threonine kinase 1	Rattus norvegicus	129-132
31240382-8	2019	Finally, we show that the activation of beta-catenin by PGE2 required signaling through the phosphatidylinositol 3-kinase (PI3K)/Akt/glycogen synthase kinase 3 beta (GSK3beta) pathway, as the PI3K inhibitor, LY-294002, disrupted the synergy between connexin43 and PGE2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-217	glycogen synthase kinase 3 alpha	Rattus norvegicus	166-174
31461843-7	2019	LY294002 treatment inhibited the AVP-dependent expression of Myocyte Enhancer Factor-2 (MEF2) and myogenin and prevented the nuclear translocation of MEF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	myocyte enhancer factor 2A	Homo sapiens	61-86
31461843-7	2019	LY294002 treatment inhibited the AVP-dependent expression of Myocyte Enhancer Factor-2 (MEF2) and myogenin and prevented the nuclear translocation of MEF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	myocyte enhancer factor 2A	Homo sapiens	88-92
31461843-7	2019	LY294002 treatment inhibited the AVP-dependent expression of Myocyte Enhancer Factor-2 (MEF2) and myogenin and prevented the nuclear translocation of MEF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	myogenin	Homo sapiens	98-106
31461843-7	2019	LY294002 treatment inhibited the AVP-dependent expression of Myocyte Enhancer Factor-2 (MEF2) and myogenin and prevented the nuclear translocation of MEF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	myocyte enhancer factor 2A	Homo sapiens	150-154
31461843-8	2019	LY294002 also repressed the AVP-dependent nuclear export of histone deacetylase 4 (HDAC4) interfering with the formation of multifactorial complexes on the myogenin promoter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	histone deacetylase 4	Homo sapiens	60-81
31461843-8	2019	LY294002 also repressed the AVP-dependent nuclear export of histone deacetylase 4 (HDAC4) interfering with the formation of multifactorial complexes on the myogenin promoter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	histone deacetylase 4	Homo sapiens	83-88
31461843-8	2019	LY294002 also repressed the AVP-dependent nuclear export of histone deacetylase 4 (HDAC4) interfering with the formation of multifactorial complexes on the myogenin promoter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	myogenin	Homo sapiens	156-164
31534465-10	2019	When U0126 or LY294002 pretreated cells alone, DP-induced p-ERK or p-PI3K downstream proteins and cell proliferation were suppressed compared to those of the control group, but EGFR was not affected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	mitogen-activated protein kinase 1	Homo sapiens	60-63
31534465-10	2019	When U0126 or LY294002 pretreated cells alone, DP-induced p-ERK or p-PI3K downstream proteins and cell proliferation were suppressed compared to those of the control group, but EGFR was not affected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	epidermal growth factor receptor	Homo sapiens	177-181
31443676-10	2019	The phosphatidylinositol 3-kinase/AKT inhibitor LY294002 was used to inhibit the phosphorylation and activity of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	113-116
31438633-7	2019	Moreover, genistein inactivated the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, while LY294002, a PI3K/Akt inhibitor, increased the apoptosis-inducing effect of genistein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	AKT serine/threonine kinase 1	Homo sapiens	115-118
31427725-8	2019	The AKT signaling pathway was activated in H446-BR and H526-BR cells accompanied by EMT progression, and AKT inhibitor LY294002 reversed the EMT progression in resistant cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Homo sapiens	4-7
31383790-10	2019	Pretreatment of cells with the Phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (LY) and small interfering RNAs (siRNAs) GLP-1R abrogated the liraglutide-induced activation of Akt and the protective effects on NPCs" apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	179-182
31427725-8	2019	The AKT signaling pathway was activated in H446-BR and H526-BR cells accompanied by EMT progression, and AKT inhibitor LY294002 reversed the EMT progression in resistant cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Homo sapiens	105-108
31270250-11	2019	Overexpressed RECK and LY294002 could decrease p-AKT and PI3K-p85 expression accompanied with unchanged expression of total protein of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	thymoma viral proto-oncogene 1	Mus musculus	49-52
31270250-11	2019	Overexpressed RECK and LY294002 could decrease p-AKT and PI3K-p85 expression accompanied with unchanged expression of total protein of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	extracellular matrix protein 1	Mus musculus	62-65
31270250-11	2019	Overexpressed RECK and LY294002 could decrease p-AKT and PI3K-p85 expression accompanied with unchanged expression of total protein of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	thymoma viral proto-oncogene 1	Mus musculus	135-138
31124219-4	2019	In the present study, we found inhibition of PI3K with LY294002 promoted beta-catenin nuclear accumulation in MCF-7 and MDA-MB-231 breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	catenin beta 1	Homo sapiens	73-85
31412591-9	2019	LY294002 suppressed TUBB3 expression in DTX-resistant and CBZ-resistant cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tubulin beta 3 class III	Homo sapiens	20-25
31274012-7	2019	We further found that the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 was able to downregulate both PPARalpha and Plin5 expression and lipid droplets formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	26-51
31274012-7	2019	We further found that the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 was able to downregulate both PPARalpha and Plin5 expression and lipid droplets formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	peroxisome proliferator activated receptor alpha	Homo sapiens	108-117
31274012-7	2019	We further found that the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 was able to downregulate both PPARalpha and Plin5 expression and lipid droplets formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	perilipin 5	Homo sapiens	122-127
30421162-7	2019	However, with the addition of PI3K-Akt-mTOR pathway-specific inhibitor LY294002, the expression of PI3K, P-Akt, P-mTOR, RUNX2, COL1, ALP, OCN, and P1NP decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Homo sapiens	35-38
30421162-7	2019	However, with the addition of PI3K-Akt-mTOR pathway-specific inhibitor LY294002, the expression of PI3K, P-Akt, P-mTOR, RUNX2, COL1, ALP, OCN, and P1NP decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	mechanistic target of rapamycin kinase	Homo sapiens	39-43
30421162-7	2019	However, with the addition of PI3K-Akt-mTOR pathway-specific inhibitor LY294002, the expression of PI3K, P-Akt, P-mTOR, RUNX2, COL1, ALP, OCN, and P1NP decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Homo sapiens	107-110
30421162-7	2019	However, with the addition of PI3K-Akt-mTOR pathway-specific inhibitor LY294002, the expression of PI3K, P-Akt, P-mTOR, RUNX2, COL1, ALP, OCN, and P1NP decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	alkaline phosphatase, placental	Homo sapiens	133-136
31124219-7	2019	Inhibition of EGFR phosphorylation with Gefitinib enhanced anti-proliferation effect of PI3K inhibitor LY294002 in MCF-7 and MDA-MB-231 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	epidermal growth factor receptor	Homo sapiens	14-18
30664822-8	2019	Loss of ARID1A increased PD-L1 via activating AKT signaling, while LY294002 (PI3K inhibitor) decreased PD-L1 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	CD274 molecule	Homo sapiens	103-108
31132356-11	2019	Furthermore, administration of PI3K/Akt/mTOR signaling pathway inhibitor LY294002 abolished the beneficial effects of ginsenoside Rg1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	thymoma viral proto-oncogene 1	Mus musculus	36-39
31132356-11	2019	Furthermore, administration of PI3K/Akt/mTOR signaling pathway inhibitor LY294002 abolished the beneficial effects of ginsenoside Rg1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	mechanistic target of rapamycin kinase	Mus musculus	40-44
31132356-11	2019	Furthermore, administration of PI3K/Akt/mTOR signaling pathway inhibitor LY294002 abolished the beneficial effects of ginsenoside Rg1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	130-133
31142701-10	2019	In addition, all the effects of QLQX on H2O2-induced mitochondria-dependent apoptosis could be blocked by the phosphoinositide 3-kinase (PI3K) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	110-135
31124219-5	2019	Combining PI3K inhibitor LY294002 with XAV-939, an inhibitor against beta-catenin nuclear accumulation, produced an additive anti-proliferation effect against breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	catenin beta 1	Homo sapiens	69-81
31120770-8	2019	Finally, the administration of LY294002, an inhibitor of PI3K, increased GSK-3beta activity and blocked nuclear beta-catenin accumulation, thereby decreasing survivin expression and elevating the Bax-to-Bcl-2 ratio after HPC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	glycogen synthase kinase 3 beta	Rattus norvegicus	73-82
31120770-8	2019	Finally, the administration of LY294002, an inhibitor of PI3K, increased GSK-3beta activity and blocked nuclear beta-catenin accumulation, thereby decreasing survivin expression and elevating the Bax-to-Bcl-2 ratio after HPC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	catenin beta 1	Rattus norvegicus	112-124
31120770-8	2019	Finally, the administration of LY294002, an inhibitor of PI3K, increased GSK-3beta activity and blocked nuclear beta-catenin accumulation, thereby decreasing survivin expression and elevating the Bax-to-Bcl-2 ratio after HPC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	BCL2 associated X, apoptosis regulator	Rattus norvegicus	196-199
31120770-8	2019	Finally, the administration of LY294002, an inhibitor of PI3K, increased GSK-3beta activity and blocked nuclear beta-catenin accumulation, thereby decreasing survivin expression and elevating the Bax-to-Bcl-2 ratio after HPC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	BCL2, apoptosis regulator	Rattus norvegicus	203-208
31173156-7	2019	Furthermore, when the Akt phosphorylation inhibitor Ly294002 was added, the improvement by TFEB to high glucose-induced apoptosis was significantly reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	22-25
31316618-6	2019	Furthermore, inhibition of Akt signaling by GDC0068 or LY294002 increased the cisplatin sensitivity of 97-7 (FGFR3S249C) cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	27-30
30887395-11	2019	Blocking these pathways using LY294002 or L-NAME attenuated the protective role of CTRP3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	C1q and tumor necrosis factor related protein 3	Mus musculus	83-88
31120192-6	2019	Inhibition of PI3K/Akt pathway by specific inhibitor, LY294002, partially reduced the protective effect of SDX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	thymoma viral proto-oncogene 1	Mus musculus	19-22
30604866-6	2019	Combining TSAIII and PI3K inhibitors, LY294002 synergically reduced the migration and invasion of 786-O and A-498 cells, as well as decreased the CTSC expression in both the cell types.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	cathepsin C	Homo sapiens	146-150
30604866-7	2019	We also observed that miR-129-5p bound to CTSC gene and suppressed the expression of CTSC and demonstrated that the miR-129-5p expression was synergically enhanced by TSAIII and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	microRNA 1295a	Homo sapiens	22-32
30604866-7	2019	We also observed that miR-129-5p bound to CTSC gene and suppressed the expression of CTSC and demonstrated that the miR-129-5p expression was synergically enhanced by TSAIII and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	cathepsin C	Homo sapiens	42-46
30604866-7	2019	We also observed that miR-129-5p bound to CTSC gene and suppressed the expression of CTSC and demonstrated that the miR-129-5p expression was synergically enhanced by TSAIII and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	cathepsin C	Homo sapiens	85-89
30604866-7	2019	We also observed that miR-129-5p bound to CTSC gene and suppressed the expression of CTSC and demonstrated that the miR-129-5p expression was synergically enhanced by TSAIII and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	microRNA 1295a	Homo sapiens	116-126
31363363-8	2019	Pretreating A549 cells with the AKT pathway inhibitor, LY294002 and the ERK pathway inhibitor, U0216 led to a decrease in HSP70 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	heat shock protein family A (Hsp70) member 4	Homo sapiens	122-127
31200125-5	2019	With the administration of LY294002, the bFGF induced HPAECs survival and PI3k/Akt signaling activation were successfully blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	fibroblast growth factor 2	Rattus norvegicus	41-45
31200125-5	2019	With the administration of LY294002, the bFGF induced HPAECs survival and PI3k/Akt signaling activation were successfully blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	79-82
30942905-10	2019	Both mTOR/Nrf2 shRNA and LY294002 could inhibit the protective effect of irisin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	fibronectin type III domain containing 5	Homo sapiens	73-79
30659604-7	2019	Pharmacological inhibitors of PI3K/Akt signaling (LY294002 or A443654) reduced the expression of MT1-MMP and impaired BMSC invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	35-38
30659604-7	2019	Pharmacological inhibitors of PI3K/Akt signaling (LY294002 or A443654) reduced the expression of MT1-MMP and impaired BMSC invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	matrix metallopeptidase 14	Homo sapiens	97-104
31173156-7	2019	Furthermore, when the Akt phosphorylation inhibitor Ly294002 was added, the improvement by TFEB to high glucose-induced apoptosis was significantly reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	transcription factor EB	Homo sapiens	91-95
31340906-8	2019	Treatment of the cells with 1.6 g/L matrine and 10 nmol/L LY294002 resulted in significantly lowered expressions of p-AKT and p-mTOR proteins and increased the expression of light chain 3B (LC 3B), an autophagy-related protein, as compared with those in the control cells (P &amp;lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	microtubule associated protein 1 light chain 3 beta	Homo sapiens	174-188
31418365-8	2019	However, the cell apoptosis and cell cycle block in Rh2+LY294002 group were more significant than that in Rh2 and LY294002 group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	Rh associated glycoprotein	Homo sapiens	52-55
31418365-8	2019	However, the cell apoptosis and cell cycle block in Rh2+LY294002 group were more significant than that in Rh2 and LY294002 group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	Rh associated glycoprotein	Homo sapiens	52-55
31418365-9	2019	Western blot showed that compared with the control group, Rh2 significantly promoted the expression of BAX and Cleaved-Caspasase 3, inhibited the expression of BCL-2, Cyclin D1 and p-AKT, furthermore LY294002 significantly promoted this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	Rh associated glycoprotein	Homo sapiens	58-61
31418381-5	2019	APS decreased the expression of Caspase-3 and inhibited the reduction of mitochondrial membrane potential induced by LY294002, moreover, APS could increase the activation of PI3K /AKT pathway in Plt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	caspase 3	Homo sapiens	32-41
31340906-4	2019	The effects of matrine and the PI3K specific inhibitor LY294002 (10 nmol/L) on AKT pathway and autophagy-related proteins in A549 cells were investigated using Western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	79-82
31340906-8	2019	Treatment of the cells with 1.6 g/L matrine and 10 nmol/L LY294002 resulted in significantly lowered expressions of p-AKT and p-mTOR proteins and increased the expression of light chain 3B (LC 3B), an autophagy-related protein, as compared with those in the control cells (P &amp;lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Homo sapiens	118-121
31340906-8	2019	Treatment of the cells with 1.6 g/L matrine and 10 nmol/L LY294002 resulted in significantly lowered expressions of p-AKT and p-mTOR proteins and increased the expression of light chain 3B (LC 3B), an autophagy-related protein, as compared with those in the control cells (P &amp;lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	mechanistic target of rapamycin kinase	Homo sapiens	128-132
31340906-8	2019	Treatment of the cells with 1.6 g/L matrine and 10 nmol/L LY294002 resulted in significantly lowered expressions of p-AKT and p-mTOR proteins and increased the expression of light chain 3B (LC 3B), an autophagy-related protein, as compared with those in the control cells (P &amp;lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	microtubule associated protein 1 light chain 3 beta	Homo sapiens	190-195
31379571-7	2019	Furthermore, the effects of BSYS on cell viability, GAP-43, p-CREB, and neurite outgrowth were clearly inhibited by LY294002, a specific antagonist of the PI3K signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	growth associated protein 43	Mus musculus	52-58
31350844-7	2019	Moreover, the difference in EPC levels among groups in the scratch wound healing experiment and migration experiment indicated that the OPG treatment promoted cell migration and AMD3100 and LY294002 inhibited the function of OPG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	TNF receptor superfamily member 11b	Homo sapiens	225-228
31350844-8	2019	In addition, OPG promoted angiogenesis and repair of bone defect in rats, and these effects were abolished by AMD3100 and LY294002 administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	TNF receptor superfamily member 11B	Rattus norvegicus	13-16
31351473-11	2019	Moreover, LY294002, an inhibitor of the PI3K/Akt/mTOR pathway, reduced the anti-inflammatory activity of DEX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	45-48
31351473-11	2019	Moreover, LY294002, an inhibitor of the PI3K/Akt/mTOR pathway, reduced the anti-inflammatory activity of DEX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	mechanistic target of rapamycin kinase	Rattus norvegicus	49-53
31023002-5	2019	Furthermore, LY294002 and Wortmannin blocked mesenchymal stem cell attachment in a dose-dependent manner, suggesting a role of phosphatidylinositol 3-kinase in MSC attachment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	musculin	Mus musculus	160-163
31379571-7	2019	Furthermore, the effects of BSYS on cell viability, GAP-43, p-CREB, and neurite outgrowth were clearly inhibited by LY294002, a specific antagonist of the PI3K signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	cAMP responsive element binding protein 1	Mus musculus	62-66
31309931-12	2019	Inhibition of Nrf2 using small interfering RNA (siRNA), or cotreatment with LY294002, an inhibitor of PI3K/Akt, abolished the protective effect on high glucose-induced injury, oxidative stress, and pro-inflammatory cytokines production by apigenin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	107-110
31309931-13	2019	LY294002 also attenuated the increase in Nrf2 protein by apigenin in high glucose-treated HK-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	41-45
31309931-13	2019	LY294002 also attenuated the increase in Nrf2 protein by apigenin in high glucose-treated HK-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hexokinase 2	Homo sapiens	90-94
31372056-10	2019	The PI3K/Akt pathway inhibitor, rapamycin, and LY294002 could partially attenuate the effect of Ezrin on cell proliferation, invasion, EMT progression, and YAP phosphorylation and translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	ezrin	Homo sapiens	96-101
30615921-16	2019	Pretreatment with LY294002, an AKT phosphorylation inhibitor, suppressed the protective role of SMI in cardiomyocytes, while pretreatment with PD98059, an ERK1/2 phosphorylation inhibitor, enhanced the effect of SMI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	31-34
31372056-10	2019	The PI3K/Akt pathway inhibitor, rapamycin, and LY294002 could partially attenuate the effect of Ezrin on cell proliferation, invasion, EMT progression, and YAP phosphorylation and translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	Yes1 associated transcriptional regulator	Homo sapiens	156-159
31213575-7	2019	Moreover, LY294002, the inhibitor of PI3K/AKT pathway, could reverse oncogenic action caused by PAR-2 activation.Conclusion: PAR-2 can promote OSCC growth and progression via activating PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	42-45
31189740-9	2019	Moreover, overexpressed miR-613, silenced FN1 or LY294002 treatment suppressed proliferation, invasion, migration, and angiogenesis in NPC cells, which was indicated by reduced expression of AKT, mTOR, MMP-2, MMP-9, VEGF, and CD31 as well as decreased ratio of Bcl-2/Bax and increased expression of Cleaved-caspase3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	thymoma viral proto-oncogene 1	Mus musculus	191-194
31189740-9	2019	Moreover, overexpressed miR-613, silenced FN1 or LY294002 treatment suppressed proliferation, invasion, migration, and angiogenesis in NPC cells, which was indicated by reduced expression of AKT, mTOR, MMP-2, MMP-9, VEGF, and CD31 as well as decreased ratio of Bcl-2/Bax and increased expression of Cleaved-caspase3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mechanistic target of rapamycin kinase	Mus musculus	196-200
31189740-9	2019	Moreover, overexpressed miR-613, silenced FN1 or LY294002 treatment suppressed proliferation, invasion, migration, and angiogenesis in NPC cells, which was indicated by reduced expression of AKT, mTOR, MMP-2, MMP-9, VEGF, and CD31 as well as decreased ratio of Bcl-2/Bax and increased expression of Cleaved-caspase3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	matrix metallopeptidase 2	Mus musculus	202-207
31189740-9	2019	Moreover, overexpressed miR-613, silenced FN1 or LY294002 treatment suppressed proliferation, invasion, migration, and angiogenesis in NPC cells, which was indicated by reduced expression of AKT, mTOR, MMP-2, MMP-9, VEGF, and CD31 as well as decreased ratio of Bcl-2/Bax and increased expression of Cleaved-caspase3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	matrix metallopeptidase 9	Mus musculus	209-214
31189740-9	2019	Moreover, overexpressed miR-613, silenced FN1 or LY294002 treatment suppressed proliferation, invasion, migration, and angiogenesis in NPC cells, which was indicated by reduced expression of AKT, mTOR, MMP-2, MMP-9, VEGF, and CD31 as well as decreased ratio of Bcl-2/Bax and increased expression of Cleaved-caspase3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	vascular endothelial growth factor A	Mus musculus	216-220
31189740-9	2019	Moreover, overexpressed miR-613, silenced FN1 or LY294002 treatment suppressed proliferation, invasion, migration, and angiogenesis in NPC cells, which was indicated by reduced expression of AKT, mTOR, MMP-2, MMP-9, VEGF, and CD31 as well as decreased ratio of Bcl-2/Bax and increased expression of Cleaved-caspase3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	B cell leukemia/lymphoma 2	Mus musculus	261-266
31189740-9	2019	Moreover, overexpressed miR-613, silenced FN1 or LY294002 treatment suppressed proliferation, invasion, migration, and angiogenesis in NPC cells, which was indicated by reduced expression of AKT, mTOR, MMP-2, MMP-9, VEGF, and CD31 as well as decreased ratio of Bcl-2/Bax and increased expression of Cleaved-caspase3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	BCL2-associated X protein	Mus musculus	267-270
31189740-10	2019	Furthermore, cell apoptosis was promoted and tumorigenesis and MVD in nude mice were inhibited with overexpression of miR-613, silenced FN1 or LY294002 treatment.Conclusion: Taken together, miR-613 inhibits angiogenesis in NPC cells through inactivating FN1-dependent AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	fibronectin 1	Mus musculus	254-257
31189740-10	2019	Furthermore, cell apoptosis was promoted and tumorigenesis and MVD in nude mice were inhibited with overexpression of miR-613, silenced FN1 or LY294002 treatment.Conclusion: Taken together, miR-613 inhibits angiogenesis in NPC cells through inactivating FN1-dependent AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	thymoma viral proto-oncogene 1	Mus musculus	268-271
31213575-7	2019	Moreover, LY294002, the inhibitor of PI3K/AKT pathway, could reverse oncogenic action caused by PAR-2 activation.Conclusion: PAR-2 can promote OSCC growth and progression via activating PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	F2R like trypsin receptor 1	Homo sapiens	96-101
31213575-7	2019	Moreover, LY294002, the inhibitor of PI3K/AKT pathway, could reverse oncogenic action caused by PAR-2 activation.Conclusion: PAR-2 can promote OSCC growth and progression via activating PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	F2R like trypsin receptor 1	Homo sapiens	125-130
31213575-7	2019	Moreover, LY294002, the inhibitor of PI3K/AKT pathway, could reverse oncogenic action caused by PAR-2 activation.Conclusion: PAR-2 can promote OSCC growth and progression via activating PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	191-194
31456644-6	2019	CCA cell lines QBC-939 and RBE were selected and treated with siRNA against GATA1 or/and a PI3K/AKT pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	thymoma viral proto-oncogene 1	Mus musculus	96-99
31034822-12	2019	U0126 and LY294002, inhibitors of Erk and Akt respectively, block SNP-enhanced KDFs proliferation effectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	mitogen-activated protein kinase 1	Homo sapiens	34-37
31034822-12	2019	U0126 and LY294002, inhibitors of Erk and Akt respectively, block SNP-enhanced KDFs proliferation effectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	42-45
31456644-11	2019	LY294002 was manifested to enhance the inhibitory effects of GATA1 inhibition on CCA progression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GATA binding protein 1	Mus musculus	61-66
30617294-9	2019	Knockdown of Nrf2 with siRNA abolished the inhibitory effects of MLB on IkappaBalpha degradation and ICAM1 up-regulation, which were mimicked by PKC inhibition (Go6983) or PI3K/Akt inhibition (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
31277394-6	2019	LY294002 (PI3K inhibitor) dramatically blocked piceatannol-mediated increasing of Nrf2 nuclear translocation, HO-1 expression, and cytoprotective activity, indicating the involvement of PI3K/Akt pathway in the cytoprotective effect of piceatannol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
31277394-6	2019	LY294002 (PI3K inhibitor) dramatically blocked piceatannol-mediated increasing of Nrf2 nuclear translocation, HO-1 expression, and cytoprotective activity, indicating the involvement of PI3K/Akt pathway in the cytoprotective effect of piceatannol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heme oxygenase 1	Homo sapiens	110-114
31277394-6	2019	LY294002 (PI3K inhibitor) dramatically blocked piceatannol-mediated increasing of Nrf2 nuclear translocation, HO-1 expression, and cytoprotective activity, indicating the involvement of PI3K/Akt pathway in the cytoprotective effect of piceatannol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	191-194
30617294-9	2019	Knockdown of Nrf2 with siRNA abolished the inhibitory effects of MLB on IkappaBalpha degradation and ICAM1 up-regulation, which were mimicked by PKC inhibition (Go6983) or PI3K/Akt inhibition (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	NFKB inhibitor alpha	Homo sapiens	72-84
30617294-9	2019	Knockdown of Nrf2 with siRNA abolished the inhibitory effects of MLB on IkappaBalpha degradation and ICAM1 up-regulation, which were mimicked by PKC inhibition (Go6983) or PI3K/Akt inhibition (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	intercellular adhesion molecule 1	Homo sapiens	101-106
31360201-10	2019	Leukotriene B4 production and 5-lipoxygenase expression were decreased by blocking the UII receptor (UT) with urantide, eliminating ROS with N-acetylcysteine and diphenyliodonium, and inhibiting Akt phosphorylation with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	arachidonate 5-lipoxygenase	Mus musculus	30-44
31006055-6	2019	The bLF-mediated proliferation was significantly blocked by the Erk phosphorylation inhibitor PD98059 or the Akt phosphorylation inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	thymoma viral proto-oncogene 1	Mus musculus	109-112
31186081-7	2019	Furthermore, ATAD2 modulated the glycometabolism of LUAD via AKT-GLUT1/HK2 pathway, as assessed using LY294002 (an inhibitor of PI3K/AKT pathway).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	ATPase family AAA domain containing 2	Homo sapiens	13-18
31186081-7	2019	Furthermore, ATAD2 modulated the glycometabolism of LUAD via AKT-GLUT1/HK2 pathway, as assessed using LY294002 (an inhibitor of PI3K/AKT pathway).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	AKT serine/threonine kinase 1	Homo sapiens	61-64
31360201-12	2019	UII also enhanced Akt phosphorylation significantly, and this effect was potently inhibited by urantide, N-acetylcysteine, diphenyliodonium and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	urotensin 2	Mus musculus	0-3
30925325-7	2019	In contrast, the effects of resistin on RAW264.7 macrophages could be abrogated by specific inhibitors for LPL (LPL-siRNA) and PI3K/AKT signaling pathway (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	resistin	Homo sapiens	28-36
31535629-10	2019	After treatment with inhibitors SB203580 and LY294002, the levels of p38 MAPK and PI3 kinase, respectively, decreased along with cell size and IL-18R expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	mitogen activated protein kinase 14	Rattus norvegicus	69-72
31186081-7	2019	Furthermore, ATAD2 modulated the glycometabolism of LUAD via AKT-GLUT1/HK2 pathway, as assessed using LY294002 (an inhibitor of PI3K/AKT pathway).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	hexokinase 2	Homo sapiens	71-74
31186081-7	2019	Furthermore, ATAD2 modulated the glycometabolism of LUAD via AKT-GLUT1/HK2 pathway, as assessed using LY294002 (an inhibitor of PI3K/AKT pathway).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	AKT serine/threonine kinase 1	Homo sapiens	133-136
30925325-7	2019	In contrast, the effects of resistin on RAW264.7 macrophages could be abrogated by specific inhibitors for LPL (LPL-siRNA) and PI3K/AKT signaling pathway (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	AKT serine/threonine kinase 1	Homo sapiens	132-135
30648253-7	2019	In addition, the protein kinase B (Akt) signal pathway inhibitor LY294002 significantly reduced the expression of TRIM27 and inhibited the dysfunction of mesangial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	protein tyrosine kinase 2 beta	Homo sapiens	17-33
31298346-11	2019	LY294002 or Bay11-7082 could decrease Ang II-induced exocytosis of gal-3 in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	38-44
31298346-11	2019	LY294002 or Bay11-7082 could decrease Ang II-induced exocytosis of gal-3 in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	lectin, galactose binding, soluble 3	Mus musculus	67-72
31071387-6	2019	A pretreatment with an AKT inhibitor, LY294002, attenuated the ability of MTAQ to activate an insulin-like signaling pathway and to enhance basal and insulin-stimulated glucose uptake and stimulate GLUT4 translocation to the plasma membrane.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	23-26
31071387-6	2019	A pretreatment with an AKT inhibitor, LY294002, attenuated the ability of MTAQ to activate an insulin-like signaling pathway and to enhance basal and insulin-stimulated glucose uptake and stimulate GLUT4 translocation to the plasma membrane.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	solute carrier family 2 member 4	Homo sapiens	198-203
31111658-5	2019	Meanwhile, we found that DMY could promote the expression of phosphorylated FoxO3a and Akt, and affect the nuclear localization of FoxO3a, when treated with the PI3K inhibitor LY294002, the effect of DMY was blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	forkhead box O3	Homo sapiens	76-82
31111658-5	2019	Meanwhile, we found that DMY could promote the expression of phosphorylated FoxO3a and Akt, and affect the nuclear localization of FoxO3a, when treated with the PI3K inhibitor LY294002, the effect of DMY was blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	AKT serine/threonine kinase 1	Homo sapiens	87-90
30648253-7	2019	In addition, the protein kinase B (Akt) signal pathway inhibitor LY294002 significantly reduced the expression of TRIM27 and inhibited the dysfunction of mesangial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	35-38
31111658-5	2019	Meanwhile, we found that DMY could promote the expression of phosphorylated FoxO3a and Akt, and affect the nuclear localization of FoxO3a, when treated with the PI3K inhibitor LY294002, the effect of DMY was blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	forkhead box O3	Homo sapiens	131-137
30648253-7	2019	In addition, the protein kinase B (Akt) signal pathway inhibitor LY294002 significantly reduced the expression of TRIM27 and inhibited the dysfunction of mesangial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	tripartite motif containing 27	Homo sapiens	114-120
31022386-4	2019	Results showed that GSK-3beta phosphorylation stimulated by dechorionation was blocked by LY294002, a specific phosphatidylinositol 3-kinase (PI3K) inhibitor, indicating involvement of PI3K in GSK-3beta phosphorylation in dechorionated eggs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	phosphatidylinositol 3-kinase 60	Bombyx mori	111-140
31308811-6	2019	Rb1 also increased Akt phosphorylation, which was suppressed by LY294002, a phosphoinositide 3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	RB transcriptional corepressor 1	Mus musculus	0-3
31308811-6	2019	Rb1 also increased Akt phosphorylation, which was suppressed by LY294002, a phosphoinositide 3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	thymoma viral proto-oncogene 1	Mus musculus	19-22
31308811-9	2019	The inhibition of Akt activation with siRNA or LY294002 also inhibited the Rb1-induced increase in phagocytosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	RB transcriptional corepressor 1	Mus musculus	75-78
31308811-11	2019	The phosphorylation of p21 activated kinase 1/2 and actin polymerization induced by IgG-opsonized beads and Rb1 were inhibited by SB203580 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	p21 (RAC1) activated kinase 1	Mus musculus	23-47
31308811-11	2019	The phosphorylation of p21 activated kinase 1/2 and actin polymerization induced by IgG-opsonized beads and Rb1 were inhibited by SB203580 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	RB transcriptional corepressor 1	Mus musculus	108-111
31022386-6	2019	The Akt phosphorylation was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	RAC serine/threonine-protein kinase	Bombyx mori	4-7
31262130-10	2019	Myocardial Bax protein expression was significantly lower in the HF+CSWT group than in the HF group and the HF+CSWT+LY294002 group (all P&lt;0.05), which was significantly higher in the HF+LY294002 group than in the HF group (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	BCL2 associated X, apoptosis regulator	Rattus norvegicus	11-14
31115571-6	2019	Furthermore, 10 micromol/PI3K inhibitor (LY294002) was applied to inhibit the PTEN/PI3K/Akt signal transduction pathway and 100 micromol/l FA was selected for treatment; alteration in the cell cycle were analyzed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	phosphatase and tensin homolog	Mus musculus	78-82
31115571-6	2019	Furthermore, 10 micromol/PI3K inhibitor (LY294002) was applied to inhibit the PTEN/PI3K/Akt signal transduction pathway and 100 micromol/l FA was selected for treatment; alteration in the cell cycle were analyzed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	thymoma viral proto-oncogene 1	Mus musculus	88-91
31115571-9	2019	Following the application of LY294002 to inhibit the PTEN/PI3K/Akt signal transduction pathway, the numbers of cells arrested in the G0/G1 phase were significantly increased in the PI3K inhibitor group compared with the control (P&lt;0.01); however, no significant change in the number of G0/G1 cells compared with FA group was observed (P&gt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	phosphatase and tensin homolog	Mus musculus	53-57
31115571-9	2019	Following the application of LY294002 to inhibit the PTEN/PI3K/Akt signal transduction pathway, the numbers of cells arrested in the G0/G1 phase were significantly increased in the PI3K inhibitor group compared with the control (P&lt;0.01); however, no significant change in the number of G0/G1 cells compared with FA group was observed (P&gt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	thymoma viral proto-oncogene 1	Mus musculus	63-66
31077419-7	2019	These inductions were suppressed by Akt inhibitor LY294002 as well as antioxidant N-acetylcysteine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	36-39
31056260-10	2019	Importantly, CDDP combined with LY294002, inhibitor of phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase (AKT) signaling, markedly decreased the expression of NRF2, HO-1, NQO1 and GCLC in drug-resistant cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	55-80
31056260-10	2019	Importantly, CDDP combined with LY294002, inhibitor of phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase (AKT) signaling, markedly decreased the expression of NRF2, HO-1, NQO1 and GCLC in drug-resistant cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	88-91
31056260-10	2019	Importantly, CDDP combined with LY294002, inhibitor of phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase (AKT) signaling, markedly decreased the expression of NRF2, HO-1, NQO1 and GCLC in drug-resistant cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	NFE2 like bZIP transcription factor 2	Homo sapiens	170-174
31056260-10	2019	Importantly, CDDP combined with LY294002, inhibitor of phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase (AKT) signaling, markedly decreased the expression of NRF2, HO-1, NQO1 and GCLC in drug-resistant cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	heme oxygenase 1	Homo sapiens	176-180
31056260-10	2019	Importantly, CDDP combined with LY294002, inhibitor of phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase (AKT) signaling, markedly decreased the expression of NRF2, HO-1, NQO1 and GCLC in drug-resistant cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	NAD(P)H quinone dehydrogenase 1	Homo sapiens	182-186
31056260-10	2019	Importantly, CDDP combined with LY294002, inhibitor of phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase (AKT) signaling, markedly decreased the expression of NRF2, HO-1, NQO1 and GCLC in drug-resistant cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	glutamate-cysteine ligase catalytic subunit	Homo sapiens	191-195
31018166-8	2019	Regarding the inhibitory mechanism, we found that the level of AKT and p-AKT can be decreased by Dex and that Ly294002, the PI3K inhibitor, can block the reversal effect of IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	insulin-like growth factor 1	Mus musculus	173-178
31018166-9	2019	Moreover, the knockdown or inhibition of COX-2 produced similar results to those of Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	cytochrome c oxidase II, mitochondrial	Mus musculus	41-46
31354916-8	2019	Moreover, all above-mentioned effects were verified and blocked by PI3K inhibitor, LY294002, in Abeta 25-35-induced PC12 cells, suggesting the precise regulative role of KXS in the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	AKT serine/threonine kinase 1	Rattus norvegicus	186-189
30964837-7	2019	In vitro, SHMT2 was overexpressed in primary hepatocytes, which were cultured in customized Dulbecco"s modified eagle media and LY294002 (an Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	serine hydroxymethyltransferase 2	Homo sapiens	10-15
31261859-6	2019	The aforementioned beneficial effects of S1P on EPCs could be inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor of LY294002 and nitric oxide synthase (NOS) inhibitor of N"-nitro-L-arginine-methyl ester hydrochloride (L-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	sphingosine-1-phosphate receptor 1	Mus musculus	41-44
31261859-6	2019	The aforementioned beneficial effects of S1P on EPCs could be inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor of LY294002 and nitric oxide synthase (NOS) inhibitor of N"-nitro-L-arginine-methyl ester hydrochloride (L-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	79-108
31261859-7	2019	The inhibitor of LY294002 inhibited S1P-stimulated activation of phosphorylated protein kinase B (AKT) (p-AKT) and endothelial nitric oxide synthase (eNOS) (p-eNOS), and down-regulated the level of eNOS significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
31261859-7	2019	The inhibitor of LY294002 inhibited S1P-stimulated activation of phosphorylated protein kinase B (AKT) (p-AKT) and endothelial nitric oxide synthase (eNOS) (p-eNOS), and down-regulated the level of eNOS significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	thymoma viral proto-oncogene 1	Mus musculus	98-101
31261859-7	2019	The inhibitor of LY294002 inhibited S1P-stimulated activation of phosphorylated protein kinase B (AKT) (p-AKT) and endothelial nitric oxide synthase (eNOS) (p-eNOS), and down-regulated the level of eNOS significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	thymoma viral proto-oncogene 1	Mus musculus	106-109
31261859-7	2019	The inhibitor of LY294002 inhibited S1P-stimulated activation of phosphorylated protein kinase B (AKT) (p-AKT) and endothelial nitric oxide synthase (eNOS) (p-eNOS), and down-regulated the level of eNOS significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	nitric oxide synthase 3, endothelial cell	Mus musculus	115-148
31261859-7	2019	The inhibitor of LY294002 inhibited S1P-stimulated activation of phosphorylated protein kinase B (AKT) (p-AKT) and endothelial nitric oxide synthase (eNOS) (p-eNOS), and down-regulated the level of eNOS significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	nitric oxide synthase 3, endothelial cell	Mus musculus	150-154
31261859-7	2019	The inhibitor of LY294002 inhibited S1P-stimulated activation of phosphorylated protein kinase B (AKT) (p-AKT) and endothelial nitric oxide synthase (eNOS) (p-eNOS), and down-regulated the level of eNOS significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	nitric oxide synthase 3, endothelial cell	Mus musculus	159-163
31261859-7	2019	The inhibitor of LY294002 inhibited S1P-stimulated activation of phosphorylated protein kinase B (AKT) (p-AKT) and endothelial nitric oxide synthase (eNOS) (p-eNOS), and down-regulated the level of eNOS significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	nitric oxide synthase 3, endothelial cell	Mus musculus	159-163
31218332-9	2019	Meanwhile, LY294002 (PI3K inhibitor) decreased the protein expression levels of MDR1, beta-catenin and Survivin, as well as the phosphorylation levels of Akt and GSK3beta in SKOV3/VCR cells (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	ATP binding cassette subfamily B member 1	Homo sapiens	80-84
31218332-9	2019	Meanwhile, LY294002 (PI3K inhibitor) decreased the protein expression levels of MDR1, beta-catenin and Survivin, as well as the phosphorylation levels of Akt and GSK3beta in SKOV3/VCR cells (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	catenin beta 1	Homo sapiens	86-98
31218332-9	2019	Meanwhile, LY294002 (PI3K inhibitor) decreased the protein expression levels of MDR1, beta-catenin and Survivin, as well as the phosphorylation levels of Akt and GSK3beta in SKOV3/VCR cells (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	AKT serine/threonine kinase 1	Homo sapiens	154-157
31218332-9	2019	Meanwhile, LY294002 (PI3K inhibitor) decreased the protein expression levels of MDR1, beta-catenin and Survivin, as well as the phosphorylation levels of Akt and GSK3beta in SKOV3/VCR cells (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	glycogen synthase kinase 3 beta	Homo sapiens	162-170
31262130-10	2019	Myocardial Bax protein expression was significantly lower in the HF+CSWT group than in the HF group and the HF+CSWT+LY294002 group (all P&lt;0.05), which was significantly higher in the HF+LY294002 group than in the HF group (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	BCL2 associated X, apoptosis regulator	Rattus norvegicus	11-14
31092704-8	2019	LY294002, a specific inhibitor of PI3K inhibited zinc-induced Akt phosphorylation, iron uptake, DMT1 and IRP2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	solute carrier family 11 member 2	Homo sapiens	96-100
31226829-7	2019	The effect of NAP on the downregulation of p-ERK and p-AKT was enhanced by the LY294002 (a PI3K inhibitor), while the inhibitor PD98059 had no obvious effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	43-48
31226829-7	2019	The effect of NAP on the downregulation of p-ERK and p-AKT was enhanced by the LY294002 (a PI3K inhibitor), while the inhibitor PD98059 had no obvious effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	55-58
31216656-9	2019	Western blot confirmed that levels of p-PI3K and p-Akt were significantly reduced in the C89- or LY294002 (PI3K inhibitor)-treated groups compared with controls.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	51-54
31216656-10	2019	Moreover, we found cooperative functions of C89 and LY294002 in inducing FGSC autophagy through suppressing the PI3K-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	117-120
31208396-14	2019	However, both K252alpha (inhibitors of Trk-A) and LY294002 (inhibitor for Akt) counteracted the effect of NGF or NGF + ILM on the protein levels of Trk-A, Akt, CyclinD1, CyclinE, CDK2, and p21.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	beta-nerve growth factor	Oryctolagus cuniculus	106-116
31208396-14	2019	However, both K252alpha (inhibitors of Trk-A) and LY294002 (inhibitor for Akt) counteracted the effect of NGF or NGF + ILM on the protein levels of Trk-A, Akt, CyclinD1, CyclinE, CDK2, and p21.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	G1/S-specific cyclin-D2	Oryctolagus cuniculus	160-168
31208396-14	2019	However, both K252alpha (inhibitors of Trk-A) and LY294002 (inhibitor for Akt) counteracted the effect of NGF or NGF + ILM on the protein levels of Trk-A, Akt, CyclinD1, CyclinE, CDK2, and p21.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	cyclin-dependent kinase 2	Oryctolagus cuniculus	179-183
31196027-10	2019	In the following experiments, we found that CDCA2 regulated CCND1 expression through activating the PI3K/AKT pathway, and confirmed this using a specific PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	cell division cycle associated 2	Homo sapiens	44-49
31196027-10	2019	In the following experiments, we found that CDCA2 regulated CCND1 expression through activating the PI3K/AKT pathway, and confirmed this using a specific PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	cyclin D1	Homo sapiens	60-65
31196027-10	2019	In the following experiments, we found that CDCA2 regulated CCND1 expression through activating the PI3K/AKT pathway, and confirmed this using a specific PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Homo sapiens	105-108
31308876-8	2019	LY294002, an Akt inhibitor, suppresses HC-067047 and specific TRPV4-siRNA-induced Nrf2 expression and its nuclear accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
31308876-8	2019	LY294002, an Akt inhibitor, suppresses HC-067047 and specific TRPV4-siRNA-induced Nrf2 expression and its nuclear accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	62-67
31308876-8	2019	LY294002, an Akt inhibitor, suppresses HC-067047 and specific TRPV4-siRNA-induced Nrf2 expression and its nuclear accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	82-86
31092704-8	2019	LY294002, a specific inhibitor of PI3K inhibited zinc-induced Akt phosphorylation, iron uptake, DMT1 and IRP2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	iron responsive element binding protein 2	Homo sapiens	105-109
31092704-9	2019	Furthermore, LY294002 also decreased the basal level of DMT1 mRNA but not protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	solute carrier family 11 member 2	Homo sapiens	56-60
31281371-13	2019	These effects were associated with the increase in p-Akt/Akt and p-eNOS, which could be abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Homo sapiens	53-56
31178586-13	2019	Treatment with the PI3K inhibitor, LY294002, reversed miR-378a and ROS-regulated proliferation and apoptosis of HLEC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	microRNA 378a	Homo sapiens	54-62
31239711-4	2019	Methods: LY294002 or insulin-like growth factor 1 (IGF-1) were used to block or stimulate the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) pathway in OSCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	149-152
31239711-10	2019	Moreover, PI3K/AKT signaling was blocked by LY294002, and activated by IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	15-18
31162482-9	2019	However, suppressing PI3K/Akt signaling using LY294002 alleviated the therapeutic effects of loganin in chondrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Rattus norvegicus	26-29
31281371-13	2019	These effects were associated with the increase in p-Akt/Akt and p-eNOS, which could be abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Homo sapiens	57-60
31281371-13	2019	These effects were associated with the increase in p-Akt/Akt and p-eNOS, which could be abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	nitric oxide synthase 3	Homo sapiens	67-71
31201145-9	2019	After blockage of Akt signaling pathway by an Akt inhibitor, LY294002, the regulatory effects of LINC00184 on the glycolysis and mitochondrial OXPHOS of EC cells were reversed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Homo sapiens	18-21
30965051-7	2019	Additionally, PI3K/Akt and ROS were also involved in Sulforaphane-induced Nrf2 activation and HO-1 expression, as revealed by the pharmacological inhibitors LY294002 and NAC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	heme oxygenase 1	Mus musculus	94-98
31201145-9	2019	After blockage of Akt signaling pathway by an Akt inhibitor, LY294002, the regulatory effects of LINC00184 on the glycolysis and mitochondrial OXPHOS of EC cells were reversed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	long intergenic non-protein coding RNA 184	Homo sapiens	97-106
31086595-11	2019	LY294002, a specific phosphoinositide 3-kinase (PI3K) inhibitor, and PD98059, a specific inhibitor of the extracellular signal-regulated kinase 1/2 (Erk1/2) pathway, eliminated the protective effects of the combination therapy on cell viability and the change in the DeltaPsim in cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen activated protein kinase 3	Rattus norvegicus	106-147
30986742-8	2019	The transgenic cell lines showed over-expression of ADRB2 weakened the PM2.5-induced cardiomyocytes apoptosis in opposite way, but was augmented by PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	adrenoceptor beta 2	Rattus norvegicus	52-57
31086595-11	2019	LY294002, a specific phosphoinositide 3-kinase (PI3K) inhibitor, and PD98059, a specific inhibitor of the extracellular signal-regulated kinase 1/2 (Erk1/2) pathway, eliminated the protective effects of the combination therapy on cell viability and the change in the DeltaPsim in cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen activated protein kinase 3	Rattus norvegicus	149-155
30942388-0	2019	Musashi 1-positive cells derived from mouse embryonic stem cells treated with LY294002 are prone to differentiate into intestinal epithelial-like tissues.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	musashi RNA-binding protein 1	Mus musculus	0-9
30707387-5	2019	Inhibitors of PI3K (LY294002) significantly suppressed the expression of IL-10, IL-37, p-PI3K, and p-Akt; however, it had no effect on the expression levels of PI3K and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	interleukin 10	Homo sapiens	73-78
30707387-5	2019	Inhibitors of PI3K (LY294002) significantly suppressed the expression of IL-10, IL-37, p-PI3K, and p-Akt; however, it had no effect on the expression levels of PI3K and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	interleukin 37	Homo sapiens	80-85
30707387-5	2019	Inhibitors of PI3K (LY294002) significantly suppressed the expression of IL-10, IL-37, p-PI3K, and p-Akt; however, it had no effect on the expression levels of PI3K and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	101-104
31934060-6	2019	Furthermore, treating rat islet INS-1 cells with a PI3K inhibitor, LY294002, blunted the effects of OPG supplement in promoting cell cycle and suppressing cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	TNF receptor superfamily member 11B	Rattus norvegicus	100-103
30942388-4	2019	A pMsi1-green fluorescence protein reporter plasmid was used to sort the Msi1-positive cells from mESCs treated and untreated with LY294002 (5 micromol/l).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	musashi RNA-binding protein 1	Mus musculus	3-7
30942388-7	2019	Compared with the Msi1-positive cells derived from mESCs without LY294002 treatment, Msi1-positive cells derived from mESCs treated with LY294002 expressed higher levels of leucine-rich repeat-containing G-protein coupled receptor, a marker of intestinal epithelial stem cells, and lower levels of Nestin, a marker of neural epithelial stem cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	musashi RNA-binding protein 1	Mus musculus	85-89
30942388-8	2019	The grafts from Msi1-positive cells treated with LY294002 contained more intestinal epithelial-like tissues and fewer neural epithelial-like tissues, compared with those from untreated Msi1-positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	musashi RNA-binding protein 1	Mus musculus	16-20
30942388-10	2019	The Msi1-positive cells selected from the cell population derived from mESCs treated with LY294002 exhibited more characteristics of intestinal epithelial stem cells than those from the untreated group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	musashi RNA-binding protein 1	Mus musculus	4-8
31257810-17	2019	U0126 did not affect Ex-4-mediated CERB activation, and LY294002 significantly reduced Ex-4-mediated CREB activation (P&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	cAMP responsive element binding protein 1	Mus musculus	101-105
30569582-7	2019	We further showed that LY294002, a specific inhibitor of PI3K, markedly decreased S100A4 expression in lung and S100A4 secretion in BALF in asthmatic mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	S100 calcium binding protein A4	Mus musculus	82-88
30762075-7	2019	In addition, we found that GLP-1 increased the expression of p-Akt in H9c2 cells with H/R injuries, and that the protective action of GLP-1 against H/R-induced injury was blocked by the GLP-1 receptor (GLP-1R) inhibitor Exendin9-39 and the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	255-263	glucagon	Rattus norvegicus	134-139
30762075-7	2019	In addition, we found that GLP-1 increased the expression of p-Akt in H9c2 cells with H/R injuries, and that the protective action of GLP-1 against H/R-induced injury was blocked by the GLP-1 receptor (GLP-1R) inhibitor Exendin9-39 and the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	255-263	glucagon-like peptide 1 receptor	Rattus norvegicus	186-200
30762075-7	2019	In addition, we found that GLP-1 increased the expression of p-Akt in H9c2 cells with H/R injuries, and that the protective action of GLP-1 against H/R-induced injury was blocked by the GLP-1 receptor (GLP-1R) inhibitor Exendin9-39 and the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	255-263	glucagon-like peptide 1 receptor	Rattus norvegicus	202-208
30762075-8	2019	Exendin9-39 and LY294002 also blocked the downregulation of ER stress protein expression by GLP-1, after H/R injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	glucagon	Rattus norvegicus	92-97
30569582-7	2019	We further showed that LY294002, a specific inhibitor of PI3K, markedly decreased S100A4 expression in lung and S100A4 secretion in BALF in asthmatic mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	S100 calcium binding protein A4	Mus musculus	112-118
30742066-11	2019	LY294002 and wortmanin, PI3K/Akt inhibitors, can abolish CAPS1-induced increase of Akt/GSK3beta activity, as well as increase of Snail protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	29-32
30742066-11	2019	LY294002 and wortmanin, PI3K/Akt inhibitors, can abolish CAPS1-induced increase of Akt/GSK3beta activity, as well as increase of Snail protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	calcium dependent secretion activator	Homo sapiens	57-62
30742066-11	2019	LY294002 and wortmanin, PI3K/Akt inhibitors, can abolish CAPS1-induced increase of Akt/GSK3beta activity, as well as increase of Snail protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	83-86
30742066-11	2019	LY294002 and wortmanin, PI3K/Akt inhibitors, can abolish CAPS1-induced increase of Akt/GSK3beta activity, as well as increase of Snail protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 alpha	Homo sapiens	87-95
30742066-11	2019	LY294002 and wortmanin, PI3K/Akt inhibitors, can abolish CAPS1-induced increase of Akt/GSK3beta activity, as well as increase of Snail protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	snail family transcriptional repressor 1	Homo sapiens	129-134
31204917-6	2019	While the pAKT expression in Bmi-1 gene-silenced group was significantly reduced; after the K562 cells were treated with LY294002 (an inhibitor of pAKT), the pAKT expression colony-forming and tumor forming abilities were reduced in comparison with untreated K562 cells; after the K562-S1 cells were treated with Bpv (an inhibitor of PTEN), the PTEN expression decreased, while the pAKT expression, colony forming and tumor-forming abilities were restored.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	29-34
31204917-6	2019	While the pAKT expression in Bmi-1 gene-silenced group was significantly reduced; after the K562 cells were treated with LY294002 (an inhibitor of pAKT), the pAKT expression colony-forming and tumor forming abilities were reduced in comparison with untreated K562 cells; after the K562-S1 cells were treated with Bpv (an inhibitor of PTEN), the PTEN expression decreased, while the pAKT expression, colony forming and tumor-forming abilities were restored.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	phosphatase and tensin homolog	Homo sapiens	334-338
31204917-6	2019	While the pAKT expression in Bmi-1 gene-silenced group was significantly reduced; after the K562 cells were treated with LY294002 (an inhibitor of pAKT), the pAKT expression colony-forming and tumor forming abilities were reduced in comparison with untreated K562 cells; after the K562-S1 cells were treated with Bpv (an inhibitor of PTEN), the PTEN expression decreased, while the pAKT expression, colony forming and tumor-forming abilities were restored.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	phosphatase and tensin homolog	Homo sapiens	345-349
31192119-7	2019	We demonstrate that apoptosis is induced in a p53-dependent manner when cells are treated with pifithrin-alpha (a p53 inhibitor) and LY294002 (an Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	AKT serine/threonine kinase 1	Homo sapiens	146-149
30776493-6	2019	Besides, PI3K inhibitor LY 294002 could attenuate MCP-1-induced P2X4R expression in cultured microglia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-33	C-C motif chemokine ligand 2	Rattus norvegicus	50-55
30753865-5	2019	The effects of BDNF in combination with AS1949490 on the Bdnf mRNA levels were blocked by inhibitors of mitogen-activated protein kinase kinase (U0126), PI3-kinase (LY294002), phospholipase Cgamma (U73122), and protein kinase C (bisindolylmaleimide I), whereas the effect of BDNF alone was inhibited only by U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	brain derived neurotrophic factor	Homo sapiens	15-19
30753865-5	2019	The effects of BDNF in combination with AS1949490 on the Bdnf mRNA levels were blocked by inhibitors of mitogen-activated protein kinase kinase (U0126), PI3-kinase (LY294002), phospholipase Cgamma (U73122), and protein kinase C (bisindolylmaleimide I), whereas the effect of BDNF alone was inhibited only by U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	brain derived neurotrophic factor	Homo sapiens	57-61
30935689-11	2019	The anti-apoptotic and neuroprotective effects of apelin-13 were partially reversed by addition of LY294002 or GLP-1R siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	apelin	Rattus norvegicus	50-56
31137461-7	2019	In addition, treatment with a phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, LY294002, suppressed the mineralization and the expression of osteoblast differentiation markers other than ALP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	30-59
31137461-7	2019	In addition, treatment with a phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, LY294002, suppressed the mineralization and the expression of osteoblast differentiation markers other than ALP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	thymoma viral proto-oncogene 1	Mus musculus	67-70
31088549-11	2019	To verify that the Akt/ERK/GSK-3beta pathway affected HDP cell proliferation, we treated HDP cells with LY294002 (an Akt inhibitor), BIO (a GSK-3beta inhibitor), and PD98059 (an ERK inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	AKT serine/threonine kinase 1	Homo sapiens	19-22
31190861-4	2019	The expression of MRP1 in C6 and U87 cells was also determined following stimulation with recombinant human VEGF and/or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	ATP binding cassette subfamily B member 1	Homo sapiens	18-22
31190861-8	2019	MRP1 expression was down-regulated following LY294002 treatment, which blocked after exposure to VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
31190861-8	2019	MRP1 expression was down-regulated following LY294002 treatment, which blocked after exposure to VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	vascular endothelial growth factor A	Homo sapiens	97-101
31068207-6	2019	Furthermore, we used LY294002 to examine the molecular mechanisms of baicalin in regulating the expression of TLR4 in vivo and in vitro using western blot, ELISA kits, and immunostaining.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	toll-like receptor 4	Mus musculus	110-114
31193821-9	2019	Moreover, the nuclear translocation of FOXO3a was inhibited by SalA both in vivo and in vitro, which was also reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	forkhead box O3	Homo sapiens	39-45
30796965-6	2019	We first demonstrated that cell viability and the expression of Trx-1 were increased by BDNF in SH-SY5Y cells, which were inhibited by the tyrosine kinase B (TrkB) inhibitor, K252a, and the phosphatidylinositol 3-kinase (PI3-K) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	239-247	thioredoxin	Homo sapiens	64-69
30089865-11	2019	The beneficial effects of SRC-1 and SRC-3 overexpression were blocked by treatment with the PI3K inhibitor LY294002 (10 mM) or with the Akt inhibitor MK-2206 (100 nM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	nuclear receptor coactivator 1	Rattus norvegicus	26-31
30649196-13	2019	LY294002 (AKT inhibitor) increases MKP3 mRNA expression levels but decreases the level of p-AKT and p-ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Bos taurus	10-13
30649196-13	2019	LY294002 (AKT inhibitor) increases MKP3 mRNA expression levels but decreases the level of p-AKT and p-ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Bos taurus	92-95
30649196-13	2019	LY294002 (AKT inhibitor) increases MKP3 mRNA expression levels but decreases the level of p-AKT and p-ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 3	Bos taurus	102-108
30796965-6	2019	We first demonstrated that cell viability and the expression of Trx-1 were increased by BDNF in SH-SY5Y cells, which were inhibited by the tyrosine kinase B (TrkB) inhibitor, K252a, and the phosphatidylinositol 3-kinase (PI3-K) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	239-247	brain derived neurotrophic factor	Homo sapiens	88-92
30796965-6	2019	We first demonstrated that cell viability and the expression of Trx-1 were increased by BDNF in SH-SY5Y cells, which were inhibited by the tyrosine kinase B (TrkB) inhibitor, K252a, and the phosphatidylinositol 3-kinase (PI3-K) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	239-247	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	190-219
30576222-7	2019	Klotho protein also activated phosphorylation of protein kinase B (AKT), whereas the addition of LY294002, a pharmacological inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked Klotho-protein-induced Nrf2/HO-1 activation and cytoprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	klotho	Homo sapiens	184-190
30576222-7	2019	Klotho protein also activated phosphorylation of protein kinase B (AKT), whereas the addition of LY294002, a pharmacological inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked Klotho-protein-induced Nrf2/HO-1 activation and cytoprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	NFE2 like bZIP transcription factor 2	Homo sapiens	207-211
30576222-7	2019	Klotho protein also activated phosphorylation of protein kinase B (AKT), whereas the addition of LY294002, a pharmacological inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked Klotho-protein-induced Nrf2/HO-1 activation and cytoprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	heme oxygenase 1	Homo sapiens	212-216
31118578-10	2019	These effects were reversed by an Akt protein inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Rattus norvegicus	34-37
30838710-11	2019	In addition, insulin markedly enhanced the phosphorylation of PI3K/AKT, p38, JNK and ERK1/2 MAPK pathways, with wortmannin or LY294002 (a PI3K-specific inhibitor) and PD98059 (a MEK1-specific inhibitor) significantly inhibiting the insulin-induced increase in MMP-2 gelatinolytic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	insulin	Homo sapiens	13-20
31118578-11	2019	Similarly, treatment with LY294002 inhibited TMP induced by interfering the Akt/Nrf2 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Rattus norvegicus	76-79
31118578-11	2019	Similarly, treatment with LY294002 inhibited TMP induced by interfering the Akt/Nrf2 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	80-84
30243029-7	2019	Mechanistically, ANO1 knockdown attenuated phosphorylation of PI3K/Akt, and inhibition of PI3K/Akt signaling by specific inhibitor LY294002 resulted in suppression of ovarian cancer cells growth promoted by ANO1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	95-98
30846331-9	2019	IFN-gamma-induced Delta42PD1 upregulation was abolished by JAK inhibitors Ruxolitinib and Tasocitinib, PI3K inhibitor LY294002, and AKT inhibitor MK-2206, respectively, but not by STAT1 inhibitor and MAPK signaling pathway inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	interferon gamma	Homo sapiens	0-9
30243029-7	2019	Mechanistically, ANO1 knockdown attenuated phosphorylation of PI3K/Akt, and inhibition of PI3K/Akt signaling by specific inhibitor LY294002 resulted in suppression of ovarian cancer cells growth promoted by ANO1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	anoctamin 1	Homo sapiens	207-211
30335670-6	2019	Pretreatment with either Akt inhibitor LY294002 or Sp1 inhibitor mithramycin A (MTM) could inhibit melatonin-induced P4Halpha1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	thymoma viral proto-oncogene 1	Mus musculus	25-28
30904493-11	2019	Blocking this pathway by the specific PI3K inhibitor-LY294002 restored HR-induced ER stress and subsequently reversed the protective effect of FABP4 silencing on HR injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	fatty acid binding protein 4	Rattus norvegicus	143-148
30683900-10	2019	Furthermore, the phosphorylation of both Akt and STAT3 was abolished by LY294002, whereas Akt phosphorylation was not affected following the inhibition of STAT3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
30683900-10	2019	Furthermore, the phosphorylation of both Akt and STAT3 was abolished by LY294002, whereas Akt phosphorylation was not affected following the inhibition of STAT3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	signal transducer and activator of transcription 3	Rattus norvegicus	49-54
30760865-6	2019	Treating mouse lung fibroblasts with LPS resulted in mTOR and Akt phosphorylation, p62 up-regulation, and significant down-regulation of autophagosomes, which could be reversed by PI3K-Akt inhibitors (Ly294002) or mTOR inhibitors (rapamycin, RAPA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	thymoma viral proto-oncogene 1	Mus musculus	185-188
30760865-6	2019	Treating mouse lung fibroblasts with LPS resulted in mTOR and Akt phosphorylation, p62 up-regulation, and significant down-regulation of autophagosomes, which could be reversed by PI3K-Akt inhibitors (Ly294002) or mTOR inhibitors (rapamycin, RAPA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	mechanistic target of rapamycin kinase	Mus musculus	214-218
30760865-6	2019	Treating mouse lung fibroblasts with LPS resulted in mTOR and Akt phosphorylation, p62 up-regulation, and significant down-regulation of autophagosomes, which could be reversed by PI3K-Akt inhibitors (Ly294002) or mTOR inhibitors (rapamycin, RAPA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	transcriptional regulating factor 1	Mus musculus	242-246
30838711-6	2019	LY294002 and rapamycin were added to inhibit the PI3K/AKT pathway and mTOR pathway, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
30942438-8	2019	The specific phosphoinositide-3 kinase (PI3K) inhibitor LY294002 promoted this effect, while insulin-like growth factor-1, a specific PI3K activator, inhibited this action.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	13-38
30718793-9	2019	IGF-1 alleviated cytolysis, which was blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	insulin like growth factor 1	Homo sapiens	0-5
30885749-7	2019	Finally, we observed that p38MAPK and Akt phosphorylation kinases were increased significantly in GM-CSF neutrophils pretreatment with Pam3CSK4 in a dose- and time-dependent manner, whereas p38MAPK inhibitor (SB2021190) and PI3K inhibitor (LY294002) attenuated the antimicrobial activities including phagocytosis, killing activity, respiratory burst, and the release of lactoferrin(LTF) by the GM-CSF induced neutrophils.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	240-248	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	98-104
30838711-6	2019	LY294002 and rapamycin were added to inhibit the PI3K/AKT pathway and mTOR pathway, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	70-74
31058093-9	2019	Finally, the introduction of PHLDA2 cDNA lacking the 3"-UTR or treatment with Akt inhibitor LY294002 partially abrogated miR-214-induced radioresistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	78-81
31008484-11	2019	PI3K inhibitor LY294002 and P38 inhibitor SB202190 blocked 17-phenyl-trinor-PGE2-induced IL-1beta and IL-6 output, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 1 beta	Homo sapiens	89-97
31008484-11	2019	PI3K inhibitor LY294002 and P38 inhibitor SB202190 blocked 17-phenyl-trinor-PGE2-induced IL-1beta and IL-6 output, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 6	Homo sapiens	102-106
31327962-12	2019	MTT reduction assays showed that early autophagy inhibitors, 3-methyladenin (3-MA) or LY294002, enhanced the loss in cell viability induced by LPS exposure for 48 h. On the contrary, the inhibition of PLD1 and PLD2 prevented the loss in cell viability induced by LPS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	phospholipase D1	Homo sapiens	201-205
31327962-12	2019	MTT reduction assays showed that early autophagy inhibitors, 3-methyladenin (3-MA) or LY294002, enhanced the loss in cell viability induced by LPS exposure for 48 h. On the contrary, the inhibition of PLD1 and PLD2 prevented the loss in cell viability induced by LPS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	phospholipase D2	Homo sapiens	210-214
30996361-5	2019	AKT showed higher protein expression at 0.5 h and 1.5 h. After blocking the PI3K/AKT signaling pathway with the PI3K blocker LY294002, PEMF could no longer increase ALP activity and the gene expressions of BMP-2, COL-1, OSX which were osteogenically related.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	AKT serine/threonine kinase 1	Rattus norvegicus	0-3
30996361-5	2019	AKT showed higher protein expression at 0.5 h and 1.5 h. After blocking the PI3K/AKT signaling pathway with the PI3K blocker LY294002, PEMF could no longer increase ALP activity and the gene expressions of BMP-2, COL-1, OSX which were osteogenically related.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	AKT serine/threonine kinase 1	Rattus norvegicus	81-84
30996361-5	2019	AKT showed higher protein expression at 0.5 h and 1.5 h. After blocking the PI3K/AKT signaling pathway with the PI3K blocker LY294002, PEMF could no longer increase ALP activity and the gene expressions of BMP-2, COL-1, OSX which were osteogenically related.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	bone morphogenetic protein 2	Rattus norvegicus	206-211
31024010-11	2019	Moreover, p-PI3K and p-AKT were significantly enhanced by PAX6, which was reversed by the addition of the PI3K-AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	paired box 6	Homo sapiens	58-62
30850176-12	2019	Furthermore, overexpression of nos2b partly rescued the LY294002-caused CVP network failure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	nitric oxide synthase 2b, inducible	Danio rerio	31-36
31058093-9	2019	Finally, the introduction of PHLDA2 cDNA lacking the 3"-UTR or treatment with Akt inhibitor LY294002 partially abrogated miR-214-induced radioresistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	microRNA 214	Homo sapiens	121-128
30456785-11	2019	Testicular phospho-Akt/total Akt ratio was significantly higher in leptin and leptin + LY294002-treated rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
30863710-9	2019	Interestingly, LY294002 decreased the expression of p-AKT and attenuated the neuroprotective effect of EPO; while, U0126 decreased the expression of p-Erk1/2 and enhanced the neuroprotective effect of EPO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	54-57
30863710-9	2019	Interestingly, LY294002 decreased the expression of p-AKT and attenuated the neuroprotective effect of EPO; while, U0126 decreased the expression of p-Erk1/2 and enhanced the neuroprotective effect of EPO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	erythropoietin	Homo sapiens	103-106
31057403-6	2019	Inhibition of PI3K and AKT by LY294002 and MK2206, respectively, or knockdown of AKT expression by siRNA blocked DAPT-induced activation of Cdc42.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	23-26
30716312-8	2019	Furthermore, both LY294002 (the PI3K-Akt inhibitor) and U0126 (the MEK-ERK inhibitor) blocked the regulation of IRS-1 on TAZ during adipogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	insulin receptor substrate 1	Rattus norvegicus	112-117
31001468-8	2019	Treatment with the PI3K/Akt inhibitor LY294002 restored the chemosensitivity of CACAN2D3-knockdown cells to cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	24-27
30877761-8	2019	Moreover, MV reduced ROS level and restored overexpressed HO-1 and AP-1 to basal level, which can be markedly reversed by AKT1 inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	thymoma viral proto-oncogene 1	Mus musculus	122-126
30673304-10	2019	Furthermore, inhibition of the PI3K/Akt pathway by LY294002 abrogated the ANXA4 overexpression-mediated effects on trophoblast behavior.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	36-39
30673304-10	2019	Furthermore, inhibition of the PI3K/Akt pathway by LY294002 abrogated the ANXA4 overexpression-mediated effects on trophoblast behavior.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	annexin A4	Homo sapiens	74-79
30456785-11	2019	Testicular phospho-Akt/total Akt ratio was significantly higher in leptin and leptin + LY294002-treated rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Rattus norvegicus	29-32
31217064-8	2019	The inhibition of Akt expression with LY294002 or STAT3 expression with AG490 abolished the TCDD-induced cyclin D1 upregulation and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	18-21
31217064-9	2019	Furthermore, LY294002 suppressed the activation of STAT3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	signal transducer and activator of transcription 3	Homo sapiens	51-56
30720058-6	2019	This observation was further confirmed using the ERK1/2 inhibitor PD98059 and the AKT inhibitor LY294002, which demonstrated that salidroside promoted PC-12 cell survival and proliferation by activating the ERK1/2 and AKT signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	AKT serine/threonine kinase 1	Rattus norvegicus	82-85
31517625-8	2019	PI3K inhi-bition by LY294002 significantly downregulated the ghrelin-induced overexpression of HOXB4 (p&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	ghrelin and obestatin prepropeptide	Rattus norvegicus	61-68
31517625-8	2019	PI3K inhi-bition by LY294002 significantly downregulated the ghrelin-induced overexpression of HOXB4 (p&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	homeo box B4	Rattus norvegicus	95-100
30600586-8	2019	Inhibitor (LY 294002, a specific inhibitor of PI3K-Akt) test result indicated that PI3K-Akt signaling pathway was involved in the inhibition of FA-induced apoptosis by Hsp70 overexpression and also active in the maintenance of GLI2 level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-20	AKT serine/threonine kinase 1	Homo sapiens	51-54
30600586-8	2019	Inhibitor (LY 294002, a specific inhibitor of PI3K-Akt) test result indicated that PI3K-Akt signaling pathway was involved in the inhibition of FA-induced apoptosis by Hsp70 overexpression and also active in the maintenance of GLI2 level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-20	AKT serine/threonine kinase 1	Homo sapiens	88-91
30600586-8	2019	Inhibitor (LY 294002, a specific inhibitor of PI3K-Akt) test result indicated that PI3K-Akt signaling pathway was involved in the inhibition of FA-induced apoptosis by Hsp70 overexpression and also active in the maintenance of GLI2 level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-20	heat shock protein family A (Hsp70) member 4	Homo sapiens	168-173
30600586-8	2019	Inhibitor (LY 294002, a specific inhibitor of PI3K-Akt) test result indicated that PI3K-Akt signaling pathway was involved in the inhibition of FA-induced apoptosis by Hsp70 overexpression and also active in the maintenance of GLI2 level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-20	GLI family zinc finger 2	Homo sapiens	227-231
29372310-12	2019	D3R protective effects against t-BHP-induced osteoblastic dysfunction were mediated by the PI3K/Akt pathway since they were completely prevented by LY294002, a PI3K/Akt specific inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	thymoma viral proto-oncogene 1	Mus musculus	96-99
29372310-12	2019	D3R protective effects against t-BHP-induced osteoblastic dysfunction were mediated by the PI3K/Akt pathway since they were completely prevented by LY294002, a PI3K/Akt specific inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	thymoma viral proto-oncogene 1	Mus musculus	165-168
30256425-6	2019	And the LY294002, a PI3K inhibitor, could reverse the effect of low SEMA6C expression on cell junctions in preantral follicles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	Mus musculus	68-74
30362584-8	2019	LY294002 suppressed Akt activation followed by the decreased SREBP-1, FASN, ACC, triglyceride, and cholesterol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	20-23
30362584-8	2019	LY294002 suppressed Akt activation followed by the decreased SREBP-1, FASN, ACC, triglyceride, and cholesterol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	sterol regulatory element binding transcription factor 1	Rattus norvegicus	61-68
30362584-8	2019	LY294002 suppressed Akt activation followed by the decreased SREBP-1, FASN, ACC, triglyceride, and cholesterol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	fatty acid synthase	Rattus norvegicus	70-74
30362584-8	2019	LY294002 suppressed Akt activation followed by the decreased SREBP-1, FASN, ACC, triglyceride, and cholesterol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	anterior capsular cataract	Mus musculus	76-79
30968158-10	2019	In addition, treatment with the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT inhibitor, LY294002, attenuated the pro-proliferative effects of exogenous FABP5 expression in Caki-1 and 786O cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	32-78
30968158-10	2019	In addition, treatment with the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT inhibitor, LY294002, attenuated the pro-proliferative effects of exogenous FABP5 expression in Caki-1 and 786O cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Homo sapiens	86-89
30968158-10	2019	In addition, treatment with the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT inhibitor, LY294002, attenuated the pro-proliferative effects of exogenous FABP5 expression in Caki-1 and 786O cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	fatty acid binding protein 5	Homo sapiens	165-170
30881494-10	2019	The PI3K/AKT inhibitor LY294002 significantly suppressed the induction of BAG3 by proteasome inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	9-12
30881494-10	2019	The PI3K/AKT inhibitor LY294002 significantly suppressed the induction of BAG3 by proteasome inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	BAG cochaperone 3	Homo sapiens	74-78
30584986-7	2019	Inhibition of PI3K/Akt/mTOR pathway by LY294002 abrogated ID-1-mediated pro-proliferation and anti-apoptosis effects in HDECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	19-22
31001561-7	2019	The GLP1 receptor antagonist exendin (9-39) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family inhibitor LY294002 not only suppressed protein kinase B (Akt), pancreatic and duodenal homeobox 1 (Pdx1), forkhead box O 1 (FoxO1), and mast cell function-associated antigen A (MafA) mRNA expression but also increased MAFB expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	52-98
31001561-7	2019	The GLP1 receptor antagonist exendin (9-39) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family inhibitor LY294002 not only suppressed protein kinase B (Akt), pancreatic and duodenal homeobox 1 (Pdx1), forkhead box O 1 (FoxO1), and mast cell function-associated antigen A (MafA) mRNA expression but also increased MAFB expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	AKT serine/threonine kinase 1	Rattus norvegicus	170-173
31001561-7	2019	The GLP1 receptor antagonist exendin (9-39) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family inhibitor LY294002 not only suppressed protein kinase B (Akt), pancreatic and duodenal homeobox 1 (Pdx1), forkhead box O 1 (FoxO1), and mast cell function-associated antigen A (MafA) mRNA expression but also increased MAFB expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	pancreatic and duodenal homeobox 1	Rattus norvegicus	176-210
31001561-7	2019	The GLP1 receptor antagonist exendin (9-39) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family inhibitor LY294002 not only suppressed protein kinase B (Akt), pancreatic and duodenal homeobox 1 (Pdx1), forkhead box O 1 (FoxO1), and mast cell function-associated antigen A (MafA) mRNA expression but also increased MAFB expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	pancreatic and duodenal homeobox 1	Rattus norvegicus	212-216
31001561-7	2019	The GLP1 receptor antagonist exendin (9-39) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family inhibitor LY294002 not only suppressed protein kinase B (Akt), pancreatic and duodenal homeobox 1 (Pdx1), forkhead box O 1 (FoxO1), and mast cell function-associated antigen A (MafA) mRNA expression but also increased MAFB expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	forkhead box O1	Rattus norvegicus	219-235
31001561-7	2019	The GLP1 receptor antagonist exendin (9-39) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family inhibitor LY294002 not only suppressed protein kinase B (Akt), pancreatic and duodenal homeobox 1 (Pdx1), forkhead box O 1 (FoxO1), and mast cell function-associated antigen A (MafA) mRNA expression but also increased MAFB expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	forkhead box O1	Rattus norvegicus	237-242
31001561-7	2019	The GLP1 receptor antagonist exendin (9-39) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family inhibitor LY294002 not only suppressed protein kinase B (Akt), pancreatic and duodenal homeobox 1 (Pdx1), forkhead box O 1 (FoxO1), and mast cell function-associated antigen A (MafA) mRNA expression but also increased MAFB expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	MAF bZIP transcription factor A	Rattus norvegicus	249-288
31001561-7	2019	The GLP1 receptor antagonist exendin (9-39) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family inhibitor LY294002 not only suppressed protein kinase B (Akt), pancreatic and duodenal homeobox 1 (Pdx1), forkhead box O 1 (FoxO1), and mast cell function-associated antigen A (MafA) mRNA expression but also increased MAFB expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	MAF bZIP transcription factor A	Rattus norvegicus	290-294
31001561-7	2019	The GLP1 receptor antagonist exendin (9-39) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family inhibitor LY294002 not only suppressed protein kinase B (Akt), pancreatic and duodenal homeobox 1 (Pdx1), forkhead box O 1 (FoxO1), and mast cell function-associated antigen A (MafA) mRNA expression but also increased MAFB expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	MAF bZIP transcription factor B	Rattus norvegicus	331-335
30984342-8	2019	As a result, nicotine-mediated induction of pAkt and survivin was abolished by LY294002; meanwhile, apoptotic NRC were increased accompanied by an increase of Cleaved Caspase-3 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	baculoviral IAP repeat-containing 5	Mus musculus	53-61
30890956-7	2019	Meanwhile, TGF-beta/Smad, PI3K/AKT and MAPK pathways were activated in this process, which was demonstrated by pretreatment with TGF-beta RI kinase inhibitor VI SB431542, PI3K inhibitor LY294002, p38 inhibitor SB203580, and ERK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	AKT serine/threonine kinase 1	Bos taurus	31-34
30881098-12	2019	Furthermore, the expression of p-Akt was decreased by LY294002 (P&lt;0.05), and amount of SIRT1 and PGC1alpha expression was inhibited by EX-527 (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
30867252-12	2019	Additionally, when the inhibitor LY294002 was added along with the resveratrol, its protective effects against IL-1beta-induced NP cell apoptosis were attenuated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	interleukin 1 alpha	Rattus norvegicus	111-119
30787052-8	2019	Further analysis showed that inhibitor LY294002 partly inhibited these protective effects of BMP-7 against senescence of human disc NP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	bone morphogenetic protein 7	Homo sapiens	93-98
31008108-6	2019	PI3K/Akt pathway inhibitor, LY294002, restored the reduced melanin content that was induced by loratadine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	5-8
30794828-9	2019	Additionally, the expression of FOXG1 and FGF2 significantly decreased when the Akt pathway were inhibited by LY294002 in SH-SY5Y cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	forkhead box G1	Homo sapiens	32-37
30794828-9	2019	Additionally, the expression of FOXG1 and FGF2 significantly decreased when the Akt pathway were inhibited by LY294002 in SH-SY5Y cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	fibroblast growth factor 2	Homo sapiens	42-46
30794828-9	2019	Additionally, the expression of FOXG1 and FGF2 significantly decreased when the Akt pathway were inhibited by LY294002 in SH-SY5Y cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Homo sapiens	80-83
30779558-11	2019	Although the inhibition of PI3K/Akt did not inhibit the Nrf2 nuclear level under 4 muM rhein, LY294002 inhibited the Nrf2 nuclear level under 2 muM rhein and blocked HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	NFE2 like bZIP transcription factor 2	Rattus norvegicus	117-121
30779558-11	2019	Although the inhibition of PI3K/Akt did not inhibit the Nrf2 nuclear level under 4 muM rhein, LY294002 inhibited the Nrf2 nuclear level under 2 muM rhein and blocked HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	heme oxygenase 1	Rattus norvegicus	166-170
30584986-7	2019	Inhibition of PI3K/Akt/mTOR pathway by LY294002 abrogated ID-1-mediated pro-proliferation and anti-apoptosis effects in HDECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	mechanistic target of rapamycin kinase	Homo sapiens	23-27
30584986-7	2019	Inhibition of PI3K/Akt/mTOR pathway by LY294002 abrogated ID-1-mediated pro-proliferation and anti-apoptosis effects in HDECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	inhibitor of DNA binding 1, HLH protein	Homo sapiens	58-62
30777932-7	2019	Similarly, we found that enhanced MEF2B expression by Akirin1 can be abrogated by treatment with LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	myocyte enhancer factor 2B	Homo sapiens	34-39
30629471-6	2019	Furthermore, pretreatment of the PI3K/Akt inhibitor LY294002 reverses all the SC79-induced hepatoprotective effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	thymoma viral proto-oncogene 1	Mus musculus	38-41
30777932-7	2019	Similarly, we found that enhanced MEF2B expression by Akirin1 can be abrogated by treatment with LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	akirin 1	Homo sapiens	54-61
30557043-6	2019	Inhibitors of bone resorption, such as alendronate, bafilomycin A1, and the PI3K inhibitor LY294002, suppressed the expression of Pmepa1 in osteoclasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	prostate transmembrane protein, androgen induced 1	Rattus norvegicus	130-136
30690059-6	2019	Furthermore, the inhibition of Akt pathway with LY294002 abolished urate-mediated elevation of GSH synthesis and neuroprotective effects both in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	Akt1	Drosophila melanogaster	31-34
30737086-8	2019	Selected PI3K/mTOR/Akt inhibitors-Wortmannin (WM), LY294002, AZD8055, and two others indeed blocked REDD1/FKBP51expression in human keratinocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	mechanistic target of rapamycin kinase	Homo sapiens	14-18
30737086-8	2019	Selected PI3K/mTOR/Akt inhibitors-Wortmannin (WM), LY294002, AZD8055, and two others indeed blocked REDD1/FKBP51expression in human keratinocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	19-22
30737086-8	2019	Selected PI3K/mTOR/Akt inhibitors-Wortmannin (WM), LY294002, AZD8055, and two others indeed blocked REDD1/FKBP51expression in human keratinocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	DNA damage inducible transcript 4	Homo sapiens	100-105
30815818-9	2019	Moreover, after ginkgolides and BB treatments, p-Akt and p-Nrf2 were significantly upregulated, which could be inhibited by LY294002 in a dose-dependent manner, meanwhile, GB exhibited more effective than GA and GK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	AKT serine/threonine kinase 1	Homo sapiens	49-52
30815818-9	2019	Moreover, after ginkgolides and BB treatments, p-Akt and p-Nrf2 were significantly upregulated, which could be inhibited by LY294002 in a dose-dependent manner, meanwhile, GB exhibited more effective than GA and GK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	NFE2 like bZIP transcription factor 2	Homo sapiens	59-63
30628639-12	2019	When LCC2 cells were treated with the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway inhibitor LY294002, the phosphorylation levels of CREB and AKT were significantly downregulated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	38-63
30359740-6	2019	Both the PI3-K inhibitor LY294002 or EGFR inhibitor Erlotinib stopped the discrepant metastatic capacity between NTS-depleted cholangiocarcinoma cells and control cells, further confirming that EGFR/AKT was required in NTS-promoted cholangiocarcinoma cell metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	neurotensin	Homo sapiens	113-116
30359740-6	2019	Both the PI3-K inhibitor LY294002 or EGFR inhibitor Erlotinib stopped the discrepant metastatic capacity between NTS-depleted cholangiocarcinoma cells and control cells, further confirming that EGFR/AKT was required in NTS-promoted cholangiocarcinoma cell metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	epidermal growth factor receptor	Homo sapiens	194-198
30391592-7	2019	The CXCL12-induced Schwann cells migration was significantly attenuated by inhibition of autophagy and activation of PI3K pathway through pretreatment with 3-MA and IGF-1 respectively, and this effect was enhanced by PI3K pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	240-248	C-X-C motif chemokine ligand 12	Homo sapiens	4-10
30628639-12	2019	When LCC2 cells were treated with the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway inhibitor LY294002, the phosphorylation levels of CREB and AKT were significantly downregulated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	cAMP responsive element binding protein 1	Homo sapiens	162-166
30628689-13	2019	Following the addition of PI3K signaling pathway inhibitor LY294002 to microglia, LPS reduced the levels of activated Akt, increased the downstream regulatory gene phosphorylation of FoxO1 and reduced microglia apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
30260006-10	2019	Treatment with Pingchuanning decoction activated PI3K/Akt/mTOR pathway and inhibited HMGB1/TLR4/NF-kappaB pathway, which could be overturned by LY294002, a PI3K antagonist, or rapamycin (Rapa), an autophagy inducer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	mechanistic target of rapamycin kinase	Homo sapiens	58-62
30260006-10	2019	Treatment with Pingchuanning decoction activated PI3K/Akt/mTOR pathway and inhibited HMGB1/TLR4/NF-kappaB pathway, which could be overturned by LY294002, a PI3K antagonist, or rapamycin (Rapa), an autophagy inducer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	high mobility group box 1	Homo sapiens	85-90
30260006-10	2019	Treatment with Pingchuanning decoction activated PI3K/Akt/mTOR pathway and inhibited HMGB1/TLR4/NF-kappaB pathway, which could be overturned by LY294002, a PI3K antagonist, or rapamycin (Rapa), an autophagy inducer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	toll like receptor 4	Homo sapiens	91-95
30260006-10	2019	Treatment with Pingchuanning decoction activated PI3K/Akt/mTOR pathway and inhibited HMGB1/TLR4/NF-kappaB pathway, which could be overturned by LY294002, a PI3K antagonist, or rapamycin (Rapa), an autophagy inducer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	nuclear factor kappa B subunit 1	Homo sapiens	96-105
30661291-10	2019	And both Akt inhibitor LY294002 and IKK inhibitor Bay117082 neutralized the p65 and p-p65 nuclear translocation induced by RPS15A overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	9-12
30661291-10	2019	And both Akt inhibitor LY294002 and IKK inhibitor Bay117082 neutralized the p65 and p-p65 nuclear translocation induced by RPS15A overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	RELA proto-oncogene, NF-kB subunit	Homo sapiens	76-79
30661291-10	2019	And both Akt inhibitor LY294002 and IKK inhibitor Bay117082 neutralized the p65 and p-p65 nuclear translocation induced by RPS15A overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	RELA proto-oncogene, NF-kB subunit	Homo sapiens	86-89
30661291-10	2019	And both Akt inhibitor LY294002 and IKK inhibitor Bay117082 neutralized the p65 and p-p65 nuclear translocation induced by RPS15A overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	ribosomal protein S15a	Homo sapiens	123-129
30639474-5	2019	Increased phosphorylated eNOS was significantly inhibited by a PI3K inhibitor LY294002 and elevated ICAM-1expression was partially blocked by the inhibitors of both PI3K and eNOS (L-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	nitric oxide synthase 3	Homo sapiens	25-29
31156786-8	2019	Mechanistically, we found PI3K/Akt signaling pathway involved in these effects, which were blocked by an Akt inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Rattus norvegicus	31-34
31156786-8	2019	Mechanistically, we found PI3K/Akt signaling pathway involved in these effects, which were blocked by an Akt inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Rattus norvegicus	105-108
30270549-9	2019	The inhibitor of PI3K/Akt (LY294002) abolished the protective effects of higenamine on OGD/R-induced neuronal cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	22-25
30272818-10	2019	These effects were associated by an increase in p-Akt/Akt and p-eNOS, and a decrease in cleaved caspase-3 could be abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	AKT serine/threonine kinase 1	Homo sapiens	50-53
30272818-10	2019	These effects were associated by an increase in p-Akt/Akt and p-eNOS, and a decrease in cleaved caspase-3 could be abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	AKT serine/threonine kinase 1	Homo sapiens	54-57
30272818-10	2019	These effects were associated by an increase in p-Akt/Akt and p-eNOS, and a decrease in cleaved caspase-3 could be abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	nitric oxide synthase 3	Homo sapiens	64-68
30272818-10	2019	These effects were associated by an increase in p-Akt/Akt and p-eNOS, and a decrease in cleaved caspase-3 could be abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	caspase 3	Homo sapiens	96-105
30989579-8	2019	In L6 myotubes treated with lipopolysaccharide (LPS) and NRG-1beta, PI3K/Akt signaling pathway-related protein expression was further determined using the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Homo sapiens	73-76
30709701-11	2019	Inhibition of the Akt/HO-1 pathway by LY294002 or ZnPP attenuated the effects of Oxy on oxidative stress and apoptosis in H2O2-stimulated HLECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	18-21
30709701-11	2019	Inhibition of the Akt/HO-1 pathway by LY294002 or ZnPP attenuated the effects of Oxy on oxidative stress and apoptosis in H2O2-stimulated HLECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	heme oxygenase 1	Homo sapiens	22-26
30639474-10	2019	Furthermore, L-NAME and/or LY294002 pre-treated HUVECs manifested decreased p38 and MK-2 phosphorylation, which was accompanied by reduced TTP and ICAM-1 protein expression as well as decreased mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	mitogen-activated protein kinase 14	Homo sapiens	76-79
30639474-10	2019	Furthermore, L-NAME and/or LY294002 pre-treated HUVECs manifested decreased p38 and MK-2 phosphorylation, which was accompanied by reduced TTP and ICAM-1 protein expression as well as decreased mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	MAPK activated protein kinase 2	Homo sapiens	84-88
30639474-10	2019	Furthermore, L-NAME and/or LY294002 pre-treated HUVECs manifested decreased p38 and MK-2 phosphorylation, which was accompanied by reduced TTP and ICAM-1 protein expression as well as decreased mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	intercellular adhesion molecule 1	Homo sapiens	147-153
30628689-13	2019	Following the addition of PI3K signaling pathway inhibitor LY294002 to microglia, LPS reduced the levels of activated Akt, increased the downstream regulatory gene phosphorylation of FoxO1 and reduced microglia apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	forkhead box O1	Rattus norvegicus	183-188
30664164-6	2019	In addition, suppression of the PI3K/AKT pathway using LY294002 or rapamycin counteracted the protective effects of ABCG2 against chemotherapeutic drug treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	37-40
30664164-6	2019	In addition, suppression of the PI3K/AKT pathway using LY294002 or rapamycin counteracted the protective effects of ABCG2 against chemotherapeutic drug treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	116-121
30880910-11	2019	Finally, the decreased p-AKT and p-mTOR expressions caused by I/R injury were upregulated by GB and inhibition of PI3K/AKT/mTOR pathway by LY294002 abolished the protective effects of GB on I/R injury, indicating that GB activated PI3K/AKT/mTOR pathway during I/R injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	mechanistic target of rapamycin kinase	Rattus norvegicus	123-127
30637828-7	2019	Importantly, EX527, SIRT1 siRNA, and LY294002, Akt siRNA, remarkably abolished the antiapoptotic effects of TASAES.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	thymoma viral proto-oncogene 1	Mus musculus	47-50
30582908-6	2019	ENO1 could modulate AKT signaling pathway in GC cells and the enhanced proliferation and migration ability induced by ENO1 overexpression was impaired after incubation with PI3K inhibitor Ly294002 in SGC7901 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	enolase 1	Homo sapiens	0-4
30816216-7	2019	Treatment with Akt inhibitor LY294002 or mTOR inhibitor rapamycin rescued the social deficit, but had no effect on hyperactivity and repetitive behavior/restricted behavior in Cntnap2-/- mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	thymoma viral proto-oncogene 1	Mus musculus	15-18
30863067-14	2019	LY294002, a PI3K (phosphatidylinositol 3-kinase)/AKT inhibitor, also suppressed the expression of TNF-alpha, IL-6 and TGF-beta, and simultaneously, reduced the production of alpha-SMA and collagen I in HKFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	49-52
30863067-14	2019	LY294002, a PI3K (phosphatidylinositol 3-kinase)/AKT inhibitor, also suppressed the expression of TNF-alpha, IL-6 and TGF-beta, and simultaneously, reduced the production of alpha-SMA and collagen I in HKFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Homo sapiens	98-107
30863067-14	2019	LY294002, a PI3K (phosphatidylinositol 3-kinase)/AKT inhibitor, also suppressed the expression of TNF-alpha, IL-6 and TGF-beta, and simultaneously, reduced the production of alpha-SMA and collagen I in HKFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 6	Homo sapiens	109-113
30863067-14	2019	LY294002, a PI3K (phosphatidylinositol 3-kinase)/AKT inhibitor, also suppressed the expression of TNF-alpha, IL-6 and TGF-beta, and simultaneously, reduced the production of alpha-SMA and collagen I in HKFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transforming growth factor beta 1	Homo sapiens	118-126
30642632-7	2019	By using PI3K/AKT inhibitor LY294002 and NF-kappaB shRNA, the increased PLK1 was reversed and cells proliferation was inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	14-17
30642632-7	2019	By using PI3K/AKT inhibitor LY294002 and NF-kappaB shRNA, the increased PLK1 was reversed and cells proliferation was inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	polo like kinase 1	Homo sapiens	72-76
30880910-11	2019	Finally, the decreased p-AKT and p-mTOR expressions caused by I/R injury were upregulated by GB and inhibition of PI3K/AKT/mTOR pathway by LY294002 abolished the protective effects of GB on I/R injury, indicating that GB activated PI3K/AKT/mTOR pathway during I/R injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Rattus norvegicus	25-28
30880910-11	2019	Finally, the decreased p-AKT and p-mTOR expressions caused by I/R injury were upregulated by GB and inhibition of PI3K/AKT/mTOR pathway by LY294002 abolished the protective effects of GB on I/R injury, indicating that GB activated PI3K/AKT/mTOR pathway during I/R injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	mechanistic target of rapamycin kinase	Rattus norvegicus	35-39
30880910-11	2019	Finally, the decreased p-AKT and p-mTOR expressions caused by I/R injury were upregulated by GB and inhibition of PI3K/AKT/mTOR pathway by LY294002 abolished the protective effects of GB on I/R injury, indicating that GB activated PI3K/AKT/mTOR pathway during I/R injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Rattus norvegicus	119-122
30880910-11	2019	Finally, the decreased p-AKT and p-mTOR expressions caused by I/R injury were upregulated by GB and inhibition of PI3K/AKT/mTOR pathway by LY294002 abolished the protective effects of GB on I/R injury, indicating that GB activated PI3K/AKT/mTOR pathway during I/R injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	mechanistic target of rapamycin kinase	Rattus norvegicus	123-127
30880910-11	2019	Finally, the decreased p-AKT and p-mTOR expressions caused by I/R injury were upregulated by GB and inhibition of PI3K/AKT/mTOR pathway by LY294002 abolished the protective effects of GB on I/R injury, indicating that GB activated PI3K/AKT/mTOR pathway during I/R injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Rattus norvegicus	119-122
30813318-12	2019	However, the phosphorylation of Akt was significantly blocked by PI3K inhibitor (LY294002), which in turn reduced the SPCP-induced proliferation and migration of CCD-986sk cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	32-35
30316647-9	2019	However, silence of Akt by siRNA transfection or pharmacological inhibitors (wortmannin and LY294002) bypassed IA-induced Girdin phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	20-23
30316647-9	2019	However, silence of Akt by siRNA transfection or pharmacological inhibitors (wortmannin and LY294002) bypassed IA-induced Girdin phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	coiled-coil domain containing 88A	Homo sapiens	122-128
30582908-6	2019	ENO1 could modulate AKT signaling pathway in GC cells and the enhanced proliferation and migration ability induced by ENO1 overexpression was impaired after incubation with PI3K inhibitor Ly294002 in SGC7901 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	AKT serine/threonine kinase 1	Homo sapiens	20-23
30582908-6	2019	ENO1 could modulate AKT signaling pathway in GC cells and the enhanced proliferation and migration ability induced by ENO1 overexpression was impaired after incubation with PI3K inhibitor Ly294002 in SGC7901 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	enolase 1	Homo sapiens	118-122
30670632-9	2019	However, LY294002 blocked these effects of NGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	nerve growth factor	Rattus norvegicus	43-46
30144073-6	2019	After treatment of shGRPR-1 and shGRPR-1 + LY294002, levels of urinary oxalate and urinary calcium in the serum, as well as positive rate of GRPR, became relatively low, levels of E-cadherin enhanced, whereas levels of Akt, PI3K, GRPR, extents of PI3K and Akt phosphorylation, alpha-SMA, Vimentin and FSP-1, OPN, MCP-1, and CD44 decreased and a number of crystals reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	cadherin 1	Mus musculus	180-190
30804672-7	2019	The enhancing effect of Gd-BG scaffolds on the osteogenic differentiation of hBMSCs was inhibited by the addition of LY294002, an inhibitor of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Rattus norvegicus	143-146
30550742-3	2019	Further more, treatment with LY294002 (specific PI3K inhibitor), PD98059 (specific ERK inhibitor), brusatol (specific Nrf2 inhibitor) and SnPP (specific HO-1 inhibitor) deprived almost all the effects of QMA in MCAO rats and OGD-treated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	heme oxygenase 1	Rattus norvegicus	153-157
30668826-11	2019	Treatment with PI3K/Akt inhibitor LY294002 in KFs with miR-188-5p inhibitor did not further reduce their proliferation, migration, and invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	20-23
30668826-11	2019	Treatment with PI3K/Akt inhibitor LY294002 in KFs with miR-188-5p inhibitor did not further reduce their proliferation, migration, and invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	microRNA 188	Homo sapiens	55-62
30668826-12	2019	The upregulation of MMP-2 and MMP-9 by miR-188-5p inhibitor could be abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	matrix metallopeptidase 2	Homo sapiens	20-25
30668826-12	2019	The upregulation of MMP-2 and MMP-9 by miR-188-5p inhibitor could be abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	matrix metallopeptidase 9	Homo sapiens	30-35
30668826-12	2019	The upregulation of MMP-2 and MMP-9 by miR-188-5p inhibitor could be abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	microRNA 188	Homo sapiens	39-46
30247509-6	2019	Immunohistochemical CD34 staining was more prominently expressed in group 2 uterus, and the treatment with LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, significantly decreased CD34 immunopositive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	CD34 antigen	Mus musculus	20-24
30247509-6	2019	Immunohistochemical CD34 staining was more prominently expressed in group 2 uterus, and the treatment with LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, significantly decreased CD34 immunopositive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	CD34 antigen	Mus musculus	187-191
30144073-6	2019	After treatment of shGRPR-1 and shGRPR-1 + LY294002, levels of urinary oxalate and urinary calcium in the serum, as well as positive rate of GRPR, became relatively low, levels of E-cadherin enhanced, whereas levels of Akt, PI3K, GRPR, extents of PI3K and Akt phosphorylation, alpha-SMA, Vimentin and FSP-1, OPN, MCP-1, and CD44 decreased and a number of crystals reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	gastrin releasing peptide receptor	Mus musculus	34-38
30074136-9	2019	Treatment of cells with PI3K inhibitor LY294002 prevented upregulation of MMP-2 and MMP-9 indicating that EGFR-mediated signalling for MMP regulation occurs through PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	matrix metallopeptidase 2	Homo sapiens	74-79
30891787-0	2019	Adiponectin and Serine/Threonine Kinase Akt Modulation by Triiodothyronine and/or LY294002 in 3T3-L1 Adipocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	thymoma viral proto-oncogene 1	Mus musculus	40-43
31210570-10	2019	Moreover, downregulation of ALP and OCN expressions by LY294002 can mimic the suppressive effects of Dex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	bone gamma-carboxyglutamate protein	Rattus norvegicus	36-39
30132214-6	2019	PI3 K inhibitor LY294002 and MDM2 inhibitor Nutlin-3a block Pgp3-induced inhibition of HeLa cell apoptosis, suggesting a critical role for the PI3K/AKT pathway and its effect on the MDM2-p53 axis in Pgp3 anti-apoptotic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	148-151
30074136-9	2019	Treatment of cells with PI3K inhibitor LY294002 prevented upregulation of MMP-2 and MMP-9 indicating that EGFR-mediated signalling for MMP regulation occurs through PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	matrix metallopeptidase 9	Homo sapiens	84-89
30074136-9	2019	Treatment of cells with PI3K inhibitor LY294002 prevented upregulation of MMP-2 and MMP-9 indicating that EGFR-mediated signalling for MMP regulation occurs through PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	epidermal growth factor receptor	Homo sapiens	106-110
30569107-8	2019	The antioxidant N-acetylcysteine, the phosphoinositide 3-kinase (PI3K)/AKT inhibitor LY294002 and the mTOR inhibitor rapamycin ameliorated the effects of high glucose.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Homo sapiens	71-74
30569126-5	2019	LY294002, a selective inhibitor of phosphoinositide 3-kinase/Akt signaling, was administered 30 min prior to ischemia, which abrogated the upregulating effects of FerA-100 mg on the expression of p-Akt, p-mTOR, 4E-BP1, p-4E-BP1 and eIF4E, the mitochondrial Bcl-2/Bax ratio and the ameliorating effect of FerA-100 mg on cerebral infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	205-209
30569126-5	2019	LY294002, a selective inhibitor of phosphoinositide 3-kinase/Akt signaling, was administered 30 min prior to ischemia, which abrogated the upregulating effects of FerA-100 mg on the expression of p-Akt, p-mTOR, 4E-BP1, p-4E-BP1 and eIF4E, the mitochondrial Bcl-2/Bax ratio and the ameliorating effect of FerA-100 mg on cerebral infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
30569126-5	2019	LY294002, a selective inhibitor of phosphoinositide 3-kinase/Akt signaling, was administered 30 min prior to ischemia, which abrogated the upregulating effects of FerA-100 mg on the expression of p-Akt, p-mTOR, 4E-BP1, p-4E-BP1 and eIF4E, the mitochondrial Bcl-2/Bax ratio and the ameliorating effect of FerA-100 mg on cerebral infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	211-217
30569126-5	2019	LY294002, a selective inhibitor of phosphoinositide 3-kinase/Akt signaling, was administered 30 min prior to ischemia, which abrogated the upregulating effects of FerA-100 mg on the expression of p-Akt, p-mTOR, 4E-BP1, p-4E-BP1 and eIF4E, the mitochondrial Bcl-2/Bax ratio and the ameliorating effect of FerA-100 mg on cerebral infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	198-201
30569126-5	2019	LY294002, a selective inhibitor of phosphoinositide 3-kinase/Akt signaling, was administered 30 min prior to ischemia, which abrogated the upregulating effects of FerA-100 mg on the expression of p-Akt, p-mTOR, 4E-BP1, p-4E-BP1 and eIF4E, the mitochondrial Bcl-2/Bax ratio and the ameliorating effect of FerA-100 mg on cerebral infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	221-227
30535464-7	2019	Blocking autophagy using LY294002 notably entrenched Ado-induced growth inhibition and cell apoptosis, as demonstrated with the increased expression of cytochrome c and p62, and the decreased expression of LC3-II.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	cytochrome c, somatic	Homo sapiens	152-164
30569126-5	2019	LY294002, a selective inhibitor of phosphoinositide 3-kinase/Akt signaling, was administered 30 min prior to ischemia, which abrogated the upregulating effects of FerA-100 mg on the expression of p-Akt, p-mTOR, 4E-BP1, p-4E-BP1 and eIF4E, the mitochondrial Bcl-2/Bax ratio and the ameliorating effect of FerA-100 mg on cerebral infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	eukaryotic translation initiation factor 4E	Rattus norvegicus	232-237
30569126-5	2019	LY294002, a selective inhibitor of phosphoinositide 3-kinase/Akt signaling, was administered 30 min prior to ischemia, which abrogated the upregulating effects of FerA-100 mg on the expression of p-Akt, p-mTOR, 4E-BP1, p-4E-BP1 and eIF4E, the mitochondrial Bcl-2/Bax ratio and the ameliorating effect of FerA-100 mg on cerebral infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2, apoptosis regulator	Rattus norvegicus	257-262
30569126-5	2019	LY294002, a selective inhibitor of phosphoinositide 3-kinase/Akt signaling, was administered 30 min prior to ischemia, which abrogated the upregulating effects of FerA-100 mg on the expression of p-Akt, p-mTOR, 4E-BP1, p-4E-BP1 and eIF4E, the mitochondrial Bcl-2/Bax ratio and the ameliorating effect of FerA-100 mg on cerebral infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	263-266
30483804-8	2019	Notably, docetaxel-inhibited SOX2 expression and growth of human CD133-expressing HCC stem cells were partially restricted following the block of the PI3K/AKT signaling pathway using the inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	SRY-box transcription factor 2	Homo sapiens	29-33
30483804-8	2019	Notably, docetaxel-inhibited SOX2 expression and growth of human CD133-expressing HCC stem cells were partially restricted following the block of the PI3K/AKT signaling pathway using the inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	prominin 1	Homo sapiens	65-70
30483804-8	2019	Notably, docetaxel-inhibited SOX2 expression and growth of human CD133-expressing HCC stem cells were partially restricted following the block of the PI3K/AKT signaling pathway using the inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	AKT serine/threonine kinase 1	Homo sapiens	155-158
30675253-9	2019	A specific PI3K inhibitor (LY294002) enhanced the Tan-IIA-inhibited expression of AKT and JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	82-85
30675253-9	2019	A specific PI3K inhibitor (LY294002) enhanced the Tan-IIA-inhibited expression of AKT and JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	mitogen-activated protein kinase 8	Homo sapiens	90-93
30535464-7	2019	Blocking autophagy using LY294002 notably entrenched Ado-induced growth inhibition and cell apoptosis, as demonstrated with the increased expression of cytochrome c and p62, and the decreased expression of LC3-II.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	nucleoporin 62	Homo sapiens	169-172
30525169-7	2019	These cardioprotective effects of DHQ were partially counteracted by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
30374891-15	2019	When rats were injected with LY294002 before resveratrol treatment, the antidepressant effect of resveratrol was significantly attenuated, TNF-alpha, IL-6 and IL-1beta levels in hippocampus and PFC increased again, Bax mRNA levels increased and Bcl-2 mRNA levels decreased in hippocampus, and Akt/GSK3beta protein expression in hippocampus decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	tumor necrosis factor	Rattus norvegicus	139-148
30374891-15	2019	When rats were injected with LY294002 before resveratrol treatment, the antidepressant effect of resveratrol was significantly attenuated, TNF-alpha, IL-6 and IL-1beta levels in hippocampus and PFC increased again, Bax mRNA levels increased and Bcl-2 mRNA levels decreased in hippocampus, and Akt/GSK3beta protein expression in hippocampus decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	interleukin 6	Rattus norvegicus	150-154
30374891-15	2019	When rats were injected with LY294002 before resveratrol treatment, the antidepressant effect of resveratrol was significantly attenuated, TNF-alpha, IL-6 and IL-1beta levels in hippocampus and PFC increased again, Bax mRNA levels increased and Bcl-2 mRNA levels decreased in hippocampus, and Akt/GSK3beta protein expression in hippocampus decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	interleukin 1 beta	Rattus norvegicus	159-167
30374891-15	2019	When rats were injected with LY294002 before resveratrol treatment, the antidepressant effect of resveratrol was significantly attenuated, TNF-alpha, IL-6 and IL-1beta levels in hippocampus and PFC increased again, Bax mRNA levels increased and Bcl-2 mRNA levels decreased in hippocampus, and Akt/GSK3beta protein expression in hippocampus decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	BCL2 associated X, apoptosis regulator	Rattus norvegicus	215-218
30374891-15	2019	When rats were injected with LY294002 before resveratrol treatment, the antidepressant effect of resveratrol was significantly attenuated, TNF-alpha, IL-6 and IL-1beta levels in hippocampus and PFC increased again, Bax mRNA levels increased and Bcl-2 mRNA levels decreased in hippocampus, and Akt/GSK3beta protein expression in hippocampus decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	BCL2, apoptosis regulator	Rattus norvegicus	245-250
30374891-15	2019	When rats were injected with LY294002 before resveratrol treatment, the antidepressant effect of resveratrol was significantly attenuated, TNF-alpha, IL-6 and IL-1beta levels in hippocampus and PFC increased again, Bax mRNA levels increased and Bcl-2 mRNA levels decreased in hippocampus, and Akt/GSK3beta protein expression in hippocampus decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Rattus norvegicus	293-296
30374891-15	2019	When rats were injected with LY294002 before resveratrol treatment, the antidepressant effect of resveratrol was significantly attenuated, TNF-alpha, IL-6 and IL-1beta levels in hippocampus and PFC increased again, Bax mRNA levels increased and Bcl-2 mRNA levels decreased in hippocampus, and Akt/GSK3beta protein expression in hippocampus decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	glycogen synthase kinase 3 beta	Rattus norvegicus	297-305
30689624-7	2019	Furthermore, investigations of the pathway showed that HTMCs pretreated with LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), downregulated the expression of phase II antioxidative enzymes, partly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	103-132
30554658-11	2019	The attenuated relaxation and the augmented Akt-p were ameliorated by LY294002, a specific inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	thymoma viral proto-oncogene 1	Mus musculus	44-47
30554658-13	2019	The level of phosphorylated FoxO1 at Ser256 and its translocation from the nucleus to the cytosol were both increased in NTG tolerance and were also inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	forkhead box O1	Mus musculus	28-33
30296564-14	2019	LY294002, an AKT inhibitor, blocked the effect of TCF21 on Bcl-xL, caspase 3 and CDDP-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	13-16
30296564-14	2019	LY294002, an AKT inhibitor, blocked the effect of TCF21 on Bcl-xL, caspase 3 and CDDP-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transcription factor 21	Homo sapiens	50-55
30296564-14	2019	LY294002, an AKT inhibitor, blocked the effect of TCF21 on Bcl-xL, caspase 3 and CDDP-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2 like 1	Homo sapiens	59-65
30296564-14	2019	LY294002, an AKT inhibitor, blocked the effect of TCF21 on Bcl-xL, caspase 3 and CDDP-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Homo sapiens	67-76
30471283-11	2019	To explore the underlying mechanism, we used LY294002 to block PI3K/Akt/GSK-3beta signaling pathway, the results from Western bolt showed that the expression of related proteins in PI3K signaling pathway were decreased with LY294002 treated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	68-71
30471283-11	2019	To explore the underlying mechanism, we used LY294002 to block PI3K/Akt/GSK-3beta signaling pathway, the results from Western bolt showed that the expression of related proteins in PI3K signaling pathway were decreased with LY294002 treated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	glycogen synthase kinase 3 alpha	Homo sapiens	72-81
30316800-7	2019	A PI3K inhibitor (LY294002), increases the expression of NIS, TTF2 and FOXO1/3, however PI3K/AKT pathway does not regulate NOX4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
30316800-7	2019	A PI3K inhibitor (LY294002), increases the expression of NIS, TTF2 and FOXO1/3, however PI3K/AKT pathway does not regulate NOX4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	transcription termination factor 2	Rattus norvegicus	62-66
30316800-7	2019	A PI3K inhibitor (LY294002), increases the expression of NIS, TTF2 and FOXO1/3, however PI3K/AKT pathway does not regulate NOX4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	forkhead box O1	Rattus norvegicus	71-78
30471283-11	2019	To explore the underlying mechanism, we used LY294002 to block PI3K/Akt/GSK-3beta signaling pathway, the results from Western bolt showed that the expression of related proteins in PI3K signaling pathway were decreased with LY294002 treated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	AKT serine/threonine kinase 1	Homo sapiens	68-71
30471283-11	2019	To explore the underlying mechanism, we used LY294002 to block PI3K/Akt/GSK-3beta signaling pathway, the results from Western bolt showed that the expression of related proteins in PI3K signaling pathway were decreased with LY294002 treated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	glycogen synthase kinase 3 alpha	Homo sapiens	72-81
30365941-13	2019	The suppression of ROS and succeeding apoptosis was achieved by pretreatment with LY294002, a PI3K/Akt pathway inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	99-102
30620754-6	2019	The phosphatidylinositol 3-kinase inhibitor LY294002 also inhibited Ang II-stimulated [3H]-leucine incorporation and ROS generation by preventing membrane translocation of Rac1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	angiogenin	Homo sapiens	68-71
30620754-6	2019	The phosphatidylinositol 3-kinase inhibitor LY294002 also inhibited Ang II-stimulated [3H]-leucine incorporation and ROS generation by preventing membrane translocation of Rac1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	Rac family small GTPase 1	Homo sapiens	172-176
30606985-7	2019	In addition, LY294002, a phosphatidylinositol 3 kinase (PI3K) inhibitor, blocked the effect of norgalanthamine on DPC proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	25-54
30662396-6	2018	Intriguingly, the neuroprotective effects of hUC-MSCs with HDAC1 silence on behavioral performance of TBI mice was markedly attenuated by LY294002, an inhibitor of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	histone deacetylase 1	Mus musculus	59-64
30662396-6	2018	Intriguingly, the neuroprotective effects of hUC-MSCs with HDAC1 silence on behavioral performance of TBI mice was markedly attenuated by LY294002, an inhibitor of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	thymoma viral proto-oncogene 1	Mus musculus	173-176
30569877-2	2019	Metformin has demonstrated its ability to inhibit cell growth and the LY294002 is the major inhibitor of PI3K/AKT/mTOR pathway that has antiangiogenic properties.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	mechanistic target of rapamycin kinase	Canis lupus familiaris	114-118
30569877-8	2019	The protein and gene expression of HIF-1 and VEGF decreased after treatment with metformin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	vascular endothelial growth factor A	Canis lupus familiaris	45-49
30569877-10	2019	CONCLUSION: Our results demonstrate the effectiveness of metformin and LY294002 in controlling the angiogenesis process in mammary tumors by VEGF and HIF-1, the most important angiogenic markers.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	vascular endothelial growth factor A	Canis lupus familiaris	141-145
30719047-8	2019	We also found that G-CSF significantly increased the CXCR4 expression and AKT phosphorylation in BM-MSCs, and the AKT pathway inhibitor LY294002 significantly diminished the ability of G-CSF to upregulate the CXCR4 expression in BM-MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	thymoma viral proto-oncogene 1	Mus musculus	74-77
30719047-8	2019	We also found that G-CSF significantly increased the CXCR4 expression and AKT phosphorylation in BM-MSCs, and the AKT pathway inhibitor LY294002 significantly diminished the ability of G-CSF to upregulate the CXCR4 expression in BM-MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	thymoma viral proto-oncogene 1	Mus musculus	114-117
30719047-8	2019	We also found that G-CSF significantly increased the CXCR4 expression and AKT phosphorylation in BM-MSCs, and the AKT pathway inhibitor LY294002 significantly diminished the ability of G-CSF to upregulate the CXCR4 expression in BM-MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	colony stimulating factor 3 (granulocyte)	Mus musculus	185-190
30719047-8	2019	We also found that G-CSF significantly increased the CXCR4 expression and AKT phosphorylation in BM-MSCs, and the AKT pathway inhibitor LY294002 significantly diminished the ability of G-CSF to upregulate the CXCR4 expression in BM-MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	chemokine (C-X-C motif) receptor 4	Mus musculus	209-214
30551489-8	2019	Importantly, LY294002, a specific PI3K inhibitor, abrogated the anti-apoptosis effect of icariin, implicating the involvement of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	134-137
31132019-7	2019	Inhibition of Akt by LY294002 reversed the migration and invasion abilities of liver cancer cells, and inhibited the ability of cells growth and angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	14-17
30755064-6	2019	In addition, Lamc1-induced increase in PKM2 expression was strongly attenuated by a PI3K inhibitor, LY294002 or a si-p110 PI3K, with a significant decrease in GLUT1 and LDHA expression, as well as decreased AKT T308 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	laminin subunit gamma 1	Homo sapiens	13-18
30755064-6	2019	In addition, Lamc1-induced increase in PKM2 expression was strongly attenuated by a PI3K inhibitor, LY294002 or a si-p110 PI3K, with a significant decrease in GLUT1 and LDHA expression, as well as decreased AKT T308 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	pyruvate kinase M1/2	Homo sapiens	39-43
31527329-6	2019	Moreover, cordycepin effectively inactivated the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, while LY294002, a PI3K/Akt inhibitor, increased the apoptosis-inducing effect of cordycepin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Homo sapiens	128-131
31622062-9	2019	3-MA and LY294002, a pan PI3-kinase inhibitor, further increased Ang II-induced podocyte apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	65-71
31026389-9	2019	Cotreatment of HeLa cells with TPA plus Pra-B or LY294002 (a PI3K inhibitor) reduced cell invasion and MMP-2/-9 expression and transcriptional activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	matrix metallopeptidase 2	Homo sapiens	103-111
31026389-11	2019	Cotreatment of HeLa cells with TPA plus Pra-B or LY294002 reduced NF-kappaB nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	nuclear factor kappa B subunit 1	Homo sapiens	66-75
30287160-7	2019	IGF-1-mediated preservation of the endothelial monolayer was reversed with LY294002 treatment, but not by Rapamycin, indicating that IGF-1 s actions on cell-cell contacts are likely mediated via the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	insulin-like growth factor 1	Rattus norvegicus	0-5
28197936-10	2019	Western blotting experiments further revealed that SAA significantly increased the expression of p-Akt and p-GSK-3beta, and the increase in p-GSK-3beta expression was attenuated after inhibition of the Akt signaling pathway with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	glycogen synthase kinase 3 beta	Rattus norvegicus	109-118
28197936-10	2019	Western blotting experiments further revealed that SAA significantly increased the expression of p-Akt and p-GSK-3beta, and the increase in p-GSK-3beta expression was attenuated after inhibition of the Akt signaling pathway with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	glycogen synthase kinase 3 beta	Rattus norvegicus	142-151
28197936-10	2019	Western blotting experiments further revealed that SAA significantly increased the expression of p-Akt and p-GSK-3beta, and the increase in p-GSK-3beta expression was attenuated after inhibition of the Akt signaling pathway with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	AKT serine/threonine kinase 1	Rattus norvegicus	202-205
30854963-8	2019	Moreover, apoM mRNA and protein levels were significantly decreased after the administration of Hcy in HepG2 cells, and this effect could be abolished by addition of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	apolipoprotein M	Homo sapiens	10-14
30287160-7	2019	IGF-1-mediated preservation of the endothelial monolayer was reversed with LY294002 treatment, but not by Rapamycin, indicating that IGF-1 s actions on cell-cell contacts are likely mediated via the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	insulin-like growth factor 1	Rattus norvegicus	133-138
30010455-11	2019	Additionally, LY294002, a specific PI3K/Akt inhibitor, significantly suppressed FA-induced Nrf2 nuclear translocation and HO-1 protein expression and inhibited FA-induced occludin and ZO-1 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Rattus norvegicus	40-43
30745840-9	2019	Moreover, overexpression of RRM2 failed to increase the expression of cyclin B1, cyclin D1, and N-cadherin when phosphorylation of AKT and ERK1/2 was suppressed by LY294002 or PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	AKT serine/threonine kinase 1	Homo sapiens	131-134
30745840-9	2019	Moreover, overexpression of RRM2 failed to increase the expression of cyclin B1, cyclin D1, and N-cadherin when phosphorylation of AKT and ERK1/2 was suppressed by LY294002 or PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	mitogen-activated protein kinase 3	Homo sapiens	139-145
30745820-13	2019	However, this beneficial effect of ICA was abolished by PI3K/AKT inhibitor LY294002 in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	thymoma viral proto-oncogene 1	Mus musculus	61-64
30010455-11	2019	Additionally, LY294002, a specific PI3K/Akt inhibitor, significantly suppressed FA-induced Nrf2 nuclear translocation and HO-1 protein expression and inhibited FA-induced occludin and ZO-1 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	91-95
30010455-11	2019	Additionally, LY294002, a specific PI3K/Akt inhibitor, significantly suppressed FA-induced Nrf2 nuclear translocation and HO-1 protein expression and inhibited FA-induced occludin and ZO-1 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	occludin	Rattus norvegicus	171-179
30010455-11	2019	Additionally, LY294002, a specific PI3K/Akt inhibitor, significantly suppressed FA-induced Nrf2 nuclear translocation and HO-1 protein expression and inhibited FA-induced occludin and ZO-1 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	tight junction protein 1	Rattus norvegicus	184-188
31068539-7	2019	Treatment of PDL cells with both the MEK1/2 inhibitor U0126 and the PI3K inhibitor LY294002 strongly attenuated TiO2-NPs-induced activation of NF-kappaB, and also the expression of COX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	nuclear factor kappa B subunit 1	Homo sapiens	143-152
29936883-11	2019	Moreover, the role of morphine in restoring the expressions of Trx-1, CyclinD1 and Cdk5 decreased by MPP+ was abolished by LY294002, phosphatidylinositol-3-kinase (PI3K)/Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	thioredoxin 1	Rattus norvegicus	63-68
29936883-11	2019	Moreover, the role of morphine in restoring the expressions of Trx-1, CyclinD1 and Cdk5 decreased by MPP+ was abolished by LY294002, phosphatidylinositol-3-kinase (PI3K)/Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	cyclin D1	Rattus norvegicus	70-78
29936883-11	2019	Moreover, the role of morphine in restoring the expressions of Trx-1, CyclinD1 and Cdk5 decreased by MPP+ was abolished by LY294002, phosphatidylinositol-3-kinase (PI3K)/Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	cyclin-dependent kinase 5	Rattus norvegicus	83-87
30726812-8	2019	Similarly, LY294002 enhanced BaP-induced increase in the key protein expression of autophagy (Beclin-1 and LC3II), while IGF-1 weakened it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	beclin 1	Homo sapiens	94-102
30726812-9	2019	Finally, the phosphorylation of FOXO4 was clearly (p &lt; 0.01) inhibited by BaP, and LY294002 suppressed this inhibitive effect of BaP, while IGF-1 strengthened it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	forkhead box O4	Homo sapiens	32-37
30387830-8	2019	LY29400, an inhibitor of PI3K, was used to additionally confirm the signal pathway mechanism of BMP2 treatment in IDD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-7	bone morphogenetic protein 2	Rattus norvegicus	96-100
30387830-13	2019	In addition, rhBMP2 inhibited cell apoptosis via upregulating the phosphorylation levels of the PI3K/Akt signaling pathway, and LY29400 pretreatment inhibited the effects of BMP2 in IL-1beta treated NP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-135	interleukin 1 beta	Rattus norvegicus	182-190
30353649-10	2019	LY294002 treatment also attenuated the IL-17A causing increases of protein levels of PI3K, AKT, MMP-2/9, Twist and the decreases of protein level of ZO-1 in the U87MG and U251 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 17A	Homo sapiens	39-45
30353649-10	2019	LY294002 treatment also attenuated the IL-17A causing increases of protein levels of PI3K, AKT, MMP-2/9, Twist and the decreases of protein level of ZO-1 in the U87MG and U251 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	91-94
30353649-10	2019	LY294002 treatment also attenuated the IL-17A causing increases of protein levels of PI3K, AKT, MMP-2/9, Twist and the decreases of protein level of ZO-1 in the U87MG and U251 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	matrix metallopeptidase 2	Homo sapiens	96-103
30353649-10	2019	LY294002 treatment also attenuated the IL-17A causing increases of protein levels of PI3K, AKT, MMP-2/9, Twist and the decreases of protein level of ZO-1 in the U87MG and U251 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tight junction protein 1	Homo sapiens	149-153
30009832-8	2019	Inactivation of the phosphoinositide 3-kinase and Akt pathways using small interfering RNA or selective inhibitors (LY294002 and MK2206) reduced the proliferative effects of CRNN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	50-53
30009832-8	2019	Inactivation of the phosphoinositide 3-kinase and Akt pathways using small interfering RNA or selective inhibitors (LY294002 and MK2206) reduced the proliferative effects of CRNN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	cornulin	Homo sapiens	174-178
31068539-7	2019	Treatment of PDL cells with both the MEK1/2 inhibitor U0126 and the PI3K inhibitor LY294002 strongly attenuated TiO2-NPs-induced activation of NF-kappaB, and also the expression of COX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	prostaglandin-endoperoxide synthase 2	Homo sapiens	181-186
30542713-12	2019	EGF-induced proliferative, invasive and migratory abilities of BxPC-3 cells were abrogated by curcumin, LY 294002 and PD 98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-113	epidermal growth factor	Homo sapiens	0-3
30145138-8	2019	The HSP27 phosphorylation induced by visfatin was also blocked by the specific PI3K/Akt inhibitor LY294002 and ERK 1/2 inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	heat shock protein family B (small) member 1	Homo sapiens	4-9
30145138-8	2019	The HSP27 phosphorylation induced by visfatin was also blocked by the specific PI3K/Akt inhibitor LY294002 and ERK 1/2 inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	nicotinamide phosphoribosyltransferase	Homo sapiens	37-45
30145138-8	2019	The HSP27 phosphorylation induced by visfatin was also blocked by the specific PI3K/Akt inhibitor LY294002 and ERK 1/2 inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	AKT serine/threonine kinase 1	Homo sapiens	84-87
30145138-9	2019	Furthermore, the visfatin impact on HUVECs as above were also blocked by LY294002 and U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	nicotinamide phosphoribosyltransferase	Homo sapiens	17-25
30483746-5	2019	The EMT effect of cocultured MCF7 cells was inhibited with the addition of anti-transforming growth factor (TGF)-beta1 or phosphoinositide 3-kinase (PI3K) inhibitor LY294002, accompanied by a significant decrease in phosphorylated (p)-mothers against decapentaplegic homolog (Smad) and p-protein kinase B (AKT) expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	122-147
31739764-10	2019	Treatment with 10 mumol/L Schisandrin of SH-SY5Y cells with the p-Akt inhibitor LY294002 demonstrated that the herbal-induced rise in p-Akt protein expression was diminished by this inhibitor indicating that signal transduction occurred in the observed cellular effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	66-69
31739764-10	2019	Treatment with 10 mumol/L Schisandrin of SH-SY5Y cells with the p-Akt inhibitor LY294002 demonstrated that the herbal-induced rise in p-Akt protein expression was diminished by this inhibitor indicating that signal transduction occurred in the observed cellular effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	136-139
30242906-6	2019	Besides, the CCDC85B-induced upregulation of phosphorylated GSK3beta and active beta-catenin was rescued following the treatment with PI3 K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	coiled-coil domain containing 85B	Homo sapiens	13-20
30242906-6	2019	Besides, the CCDC85B-induced upregulation of phosphorylated GSK3beta and active beta-catenin was rescued following the treatment with PI3 K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	glycogen synthase kinase 3 beta	Homo sapiens	60-68
30242906-6	2019	Besides, the CCDC85B-induced upregulation of phosphorylated GSK3beta and active beta-catenin was rescued following the treatment with PI3 K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	catenin beta 1	Homo sapiens	80-92
30662655-19	2018	After administration of LY294002, the expression levels of Beclin-1, LC3 II/LC3-I, and GPX4 significantly decreased, but Cyt C significantly increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	beclin 1, autophagy related	Mus musculus	59-67
30098425-8	2018	Moreover, the specific PI3-K inhibitor LY294002 abolished the discrepancy in the growth and metastatic capacity between THOR-silenced HCC cells and control cells, which further confirmed that AKT was required in THOR-driven HCC cell growth and metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	192-195
30655908-7	2019	Notably, pretreating C666-1 cells with the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002 suggested that with increasing concentrations of LY294002, triptolide exhibited decreasing ability to suppress proliferation and induce apoptosis in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	43-72
30655908-7	2019	Notably, pretreating C666-1 cells with the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002 suggested that with increasing concentrations of LY294002, triptolide exhibited decreasing ability to suppress proliferation and induce apoptosis in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	AKT serine/threonine kinase 1	Homo sapiens	80-83
30655908-7	2019	Notably, pretreating C666-1 cells with the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002 suggested that with increasing concentrations of LY294002, triptolide exhibited decreasing ability to suppress proliferation and induce apoptosis in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	43-72
30655908-7	2019	Notably, pretreating C666-1 cells with the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002 suggested that with increasing concentrations of LY294002, triptolide exhibited decreasing ability to suppress proliferation and induce apoptosis in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	AKT serine/threonine kinase 1	Homo sapiens	80-83
30577658-11	2018	Blocking the Akt pathway with LY294002, a PI3K inhibitor, reversed the cytoprotective effect of TAS against TNF-alpha-induced endothelial cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	THAS	Homo sapiens	96-99
30577658-11	2018	Blocking the Akt pathway with LY294002, a PI3K inhibitor, reversed the cytoprotective effect of TAS against TNF-alpha-induced endothelial cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	tumor necrosis factor	Homo sapiens	108-117
30577658-12	2018	Moreover, LY294002 partially abolished the effects of TAS on the upregulation of the Bcl-2 family of proteins and the downregulation of Bax protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	THAS	Homo sapiens	54-57
30662670-6	2018	Of note, PI3K/Akt/Cox2 axis is activated in the co-culturing system and LY294002 abrogates the co-culturing system"s effects on cell proliferation, apoptosis and cytokines secretion, which are reversed by synergistically overexpressing Cox2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	236-240
30459239-9	2018	Further analysis showed that addition of LY294002 and FK-506 partly attenuated these protective effects of OP-1 against NP cell apoptosis and activation of the PI3K/Akt/mTOR pathway in a hyperosmotic culture.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Rattus norvegicus	165-168
30459239-9	2018	Further analysis showed that addition of LY294002 and FK-506 partly attenuated these protective effects of OP-1 against NP cell apoptosis and activation of the PI3K/Akt/mTOR pathway in a hyperosmotic culture.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	mechanistic target of rapamycin kinase	Rattus norvegicus	169-173
30662655-19	2018	After administration of LY294002, the expression levels of Beclin-1, LC3 II/LC3-I, and GPX4 significantly decreased, but Cyt C significantly increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	69-72
30662655-19	2018	After administration of LY294002, the expression levels of Beclin-1, LC3 II/LC3-I, and GPX4 significantly decreased, but Cyt C significantly increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	76-79
30662655-19	2018	After administration of LY294002, the expression levels of Beclin-1, LC3 II/LC3-I, and GPX4 significantly decreased, but Cyt C significantly increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	glutathione peroxidase 4	Mus musculus	87-91
30597772-7	2018	Conversely, the activated effects of hydromorphine on the phosphorylation of Akt and eNOS, and NO release were totally reversed by LY294002, which, used individually, show the same influence on reperfusion injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Rattus norvegicus	77-80
30612403-7	2018	In addition, LY294002, a PI3K/AKT pathway inhibitor, increased PRDM1 and PTEN expression in a dose dependent manner in YT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	30-33
30612403-7	2018	In addition, LY294002, a PI3K/AKT pathway inhibitor, increased PRDM1 and PTEN expression in a dose dependent manner in YT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	PR/SET domain 1	Homo sapiens	63-68
30612403-7	2018	In addition, LY294002, a PI3K/AKT pathway inhibitor, increased PRDM1 and PTEN expression in a dose dependent manner in YT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	phosphatase and tensin homolog	Homo sapiens	73-77
30622672-5	2018	Treatment of the cells with apocynin (an NADPH oxidase inhibitor), dithiothreitol/NaHS (reducing agents), or LY294002 (a phosphoinositide 3-kinase (PI3K) inhibitor) prevented palmitate-induced ENaC activity, whereas thimerosal (an oxidizing agent) mimicked the effects of palmitate on ENaC activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	121-146
30130150-8	2018	The activity of a reporter construct containing the ABCA1 promoter was induced by IGF1, and this effect was blocked by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	52-57
30130150-8	2018	The activity of a reporter construct containing the ABCA1 promoter was induced by IGF1, and this effect was blocked by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	insulin-like growth factor 1	Mus musculus	82-86
30195142-10	2018	Importantly, the combined treatment of T-cadherin with the PI3K inhibitor LY294002 enhanced the inhibitory effect of T-cadherin on cellular proliferation and the PI3K/AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	cadherin 13	Homo sapiens	39-49
30195142-10	2018	Importantly, the combined treatment of T-cadherin with the PI3K inhibitor LY294002 enhanced the inhibitory effect of T-cadherin on cellular proliferation and the PI3K/AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	cadherin 13	Homo sapiens	117-127
30195142-10	2018	Importantly, the combined treatment of T-cadherin with the PI3K inhibitor LY294002 enhanced the inhibitory effect of T-cadherin on cellular proliferation and the PI3K/AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	167-170
30195142-10	2018	Importantly, the combined treatment of T-cadherin with the PI3K inhibitor LY294002 enhanced the inhibitory effect of T-cadherin on cellular proliferation and the PI3K/AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	mechanistic target of rapamycin kinase	Homo sapiens	171-175
30530508-5	2018	Furthermore, our results showed that it was LY294002 (the PI3K-Akt inhibitor), other than UO126 (the MEK-ERK inhibitor), that inhibited the IRS-1 induced upregulation of TAZ expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	insulin receptor substrate 1	Rattus norvegicus	140-145
30622592-8	2018	The effect of GST preventing mitochondrial dysfunction was antagonized by pretreatment of PD98059 and LY294002, selective inhibitors of ERK and Akt, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	mitogen-activated protein kinase 1	Homo sapiens	136-139
30622592-8	2018	The effect of GST preventing mitochondrial dysfunction was antagonized by pretreatment of PD98059 and LY294002, selective inhibitors of ERK and Akt, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	AKT serine/threonine kinase 1	Homo sapiens	144-147
30404729-9	2018	LY294002 not only attenuated differentiation of C3H10T1/2 MSCs into brown adipocytes, but also reduced phosphorylated AKT and mTOR levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	118-121
30404729-9	2018	LY294002 not only attenuated differentiation of C3H10T1/2 MSCs into brown adipocytes, but also reduced phosphorylated AKT and mTOR levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Mus musculus	126-130
30404729-10	2018	However, co-treatment with liraglutide and LY294002 decreased the expression of adipogenic and mitochondrial genes, mtDNA, and phosphorylated AKT and mTOR levels compared to C3H10T1/2 MSCs treated with liraglutide 100 nM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	thymoma viral proto-oncogene 1	Mus musculus	142-145
30404729-10	2018	However, co-treatment with liraglutide and LY294002 decreased the expression of adipogenic and mitochondrial genes, mtDNA, and phosphorylated AKT and mTOR levels compared to C3H10T1/2 MSCs treated with liraglutide 100 nM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	mechanistic target of rapamycin kinase	Mus musculus	150-154
30323140-10	2018	The PI3K/Akt signaling pathway inhibitor LY294002 (10 mM) inhibited Akt phosphorylation, as well as Nrf2 and HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	thymoma viral proto-oncogene 1	Mus musculus	9-12
30280183-5	2018	The function of protein kinase B (AKT) and heme oxygenase-1 (HO-1) activation on luteolin mediated I/R injury protection was assessed by administration of phosphoinositide-3-kinase/AKT inhibitor LY294002 and HO-1 inhibitor ZNPP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	heme oxygenase 1	Homo sapiens	61-65
30280183-5	2018	The function of protein kinase B (AKT) and heme oxygenase-1 (HO-1) activation on luteolin mediated I/R injury protection was assessed by administration of phosphoinositide-3-kinase/AKT inhibitor LY294002 and HO-1 inhibitor ZNPP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	AKT serine/threonine kinase 1	Homo sapiens	181-184
30387816-9	2018	In addition, LY294002, a PI3K inhibitor, reduced the PI3K and p-Akt protein expression in the PAECs and reversed the effects of miR-371b-5p overexpression on the apoptosis of PAECs in rats with monocrotaline-induced PAH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	membrane associated ring-CH-type finger 8	Rattus norvegicus	128-131
29478280-10	2018	The effect of miR-139-5p was mediated by PI3K inhibition, as suggested by the decrease in proliferation and phosphorylation of AKT and p70 S6K after treatment with the direct PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	AKT serine/threonine kinase 1	Homo sapiens	127-130
29478280-10	2018	The effect of miR-139-5p was mediated by PI3K inhibition, as suggested by the decrease in proliferation and phosphorylation of AKT and p70 S6K after treatment with the direct PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	ribosomal protein S6 kinase B1	Homo sapiens	135-142
31949670-11	2018	The protective effects of melatonin were abolished by a PI3K/Akt-inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
30156477-5	2018	PI3K inhibitor LY294002 was injected intracerebroventricularly to inhibit the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Rattus norvegicus	83-86
30156477-10	2018	RESULTS: RSV significantly reduced neurological deficit scores, cerebral water content and the enzymatic activity of MPO, all of which were abolished by LY294002 administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	myeloperoxidase	Rattus norvegicus	117-120
30156477-12	2018	RSV significantly inhibited upregulated the protein expression of COX2 24 h after MCAO, which effect was abolished by LY294002 administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	66-70
30323140-10	2018	The PI3K/Akt signaling pathway inhibitor LY294002 (10 mM) inhibited Akt phosphorylation, as well as Nrf2 and HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	thymoma viral proto-oncogene 1	Mus musculus	68-71
30323140-10	2018	The PI3K/Akt signaling pathway inhibitor LY294002 (10 mM) inhibited Akt phosphorylation, as well as Nrf2 and HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	100-104
30323140-10	2018	The PI3K/Akt signaling pathway inhibitor LY294002 (10 mM) inhibited Akt phosphorylation, as well as Nrf2 and HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	heme oxygenase 1	Mus musculus	109-113
30717560-6	2018	These effects were inhibited by LY294002, a blocker of PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
30466606-8	2018	Rhein also increased the phosphorylation of AKT and GSK3beta, an effect that was eliminated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Rattus norvegicus	44-47
30466606-9	2018	GSK3beta silencing by siRNA showed similar effect as LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	glycogen synthase kinase 3 beta	Rattus norvegicus	0-8
30300626-12	2018	Additionally, co-treatment with ERK1/2 (U0126) or an AKT inhibitor (LY294002) plus chrysophanol reduced cell proliferation, whereas P38 (SB203580) and a JNK inhibitor (SP600125) showed synergic effects only in BT-474 cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	53-56
30333255-8	2018	The effects of GCN5 overexpression on cell proliferation and invasion were suppressed by LY294002, In conclusion, these data demonstrated the negative effect of up-regulated GCN5 in IL-6-induced metastasis and EMT in PCa cells through PI3K/PTEN/Akt signaling pathway down-regulating Egr-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	lysine acetyltransferase 2A	Homo sapiens	15-19
30333255-8	2018	The effects of GCN5 overexpression on cell proliferation and invasion were suppressed by LY294002, In conclusion, these data demonstrated the negative effect of up-regulated GCN5 in IL-6-induced metastasis and EMT in PCa cells through PI3K/PTEN/Akt signaling pathway down-regulating Egr-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	interleukin 6	Homo sapiens	182-186
30479372-7	2018	The PI3K/AKT inhibitor LY294002 inhibited KLF8-induced VEGFA expression, whereas PI3K/AKT signaling pathway proteins, such as P-PDK1(Ser241) and P-AKT(Thr308), were decreased significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	thymoma viral proto-oncogene 1	Mus musculus	9-12
30471224-10	2018	The addition of LY294002 inhibited klotho protein downregulation of GRP78, CHOP, caspase-3, caspase-9, and caspase-12 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	klotho	Homo sapiens	35-41
30471224-10	2018	The addition of LY294002 inhibited klotho protein downregulation of GRP78, CHOP, caspase-3, caspase-9, and caspase-12 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	heat shock protein family A (Hsp70) member 5	Homo sapiens	68-73
30471224-10	2018	The addition of LY294002 inhibited klotho protein downregulation of GRP78, CHOP, caspase-3, caspase-9, and caspase-12 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	DNA damage inducible transcript 3	Homo sapiens	75-79
30471224-10	2018	The addition of LY294002 inhibited klotho protein downregulation of GRP78, CHOP, caspase-3, caspase-9, and caspase-12 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	caspase 3	Homo sapiens	81-90
30471224-10	2018	The addition of LY294002 inhibited klotho protein downregulation of GRP78, CHOP, caspase-3, caspase-9, and caspase-12 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	caspase 9	Homo sapiens	92-101
30479372-7	2018	The PI3K/AKT inhibitor LY294002 inhibited KLF8-induced VEGFA expression, whereas PI3K/AKT signaling pathway proteins, such as P-PDK1(Ser241) and P-AKT(Thr308), were decreased significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	Kruppel-like factor 8	Mus musculus	42-46
30479372-7	2018	The PI3K/AKT inhibitor LY294002 inhibited KLF8-induced VEGFA expression, whereas PI3K/AKT signaling pathway proteins, such as P-PDK1(Ser241) and P-AKT(Thr308), were decreased significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	vascular endothelial growth factor A	Mus musculus	55-60
30444896-6	2018	Pharmacological inhibitor of PI 3 kinase, Ly 294002 and pan Akt kinase inhibitor MK 2206 prevented the TGFbeta induced downregulation of deptor, resulting in suppression of both mTORC1 and mTORC2 activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-51	transforming growth factor, beta 1	Rattus norvegicus	103-110
30450569-8	2018	Subsequently, LY294002, as the phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway inhibitor, was used to further confirm the regulatory mechanism of STXBP5-AS1, which showed that knockdown of STXBP5-AS1 could rescue the expression of STXBP5 and p-AKT1 protein expression levels in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	protein tyrosine kinase 2 beta	Homo sapiens	61-77
30450569-8	2018	Subsequently, LY294002, as the phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway inhibitor, was used to further confirm the regulatory mechanism of STXBP5-AS1, which showed that knockdown of STXBP5-AS1 could rescue the expression of STXBP5 and p-AKT1 protein expression levels in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	84-87
30450569-8	2018	Subsequently, LY294002, as the phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway inhibitor, was used to further confirm the regulatory mechanism of STXBP5-AS1, which showed that knockdown of STXBP5-AS1 could rescue the expression of STXBP5 and p-AKT1 protein expression levels in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	STXBP5 antisense RNA 1	Homo sapiens	164-174
30450569-8	2018	Subsequently, LY294002, as the phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway inhibitor, was used to further confirm the regulatory mechanism of STXBP5-AS1, which showed that knockdown of STXBP5-AS1 could rescue the expression of STXBP5 and p-AKT1 protein expression levels in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	syntaxin binding protein 5	Homo sapiens	164-170
30510432-5	2018	In addition, a specific AKT inhibitor LY294002 was utilized to examine the correlation between the expression of TRIM37 and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	24-27
30581841-4	2018	The results showed that fucoxanthin could upregulate the mRNA and protein levels of the cytoprotective genes and promote the nuclear translocation of Nrf2, which could be inhibited by the PI3K inhibitor of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	206-214	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
30662601-9	2018	Furthermore, the neuroprotective and angiogenic effects of NGF can be significantly attenuated by the phosphatidylinositide 3-kinase (PI3K)/Akt pathway antagonist LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	AKT serine/threonine kinase 1	Rattus norvegicus	140-143
30510432-5	2018	In addition, a specific AKT inhibitor LY294002 was utilized to examine the correlation between the expression of TRIM37 and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	tripartite motif containing 37	Homo sapiens	113-119
30510432-5	2018	In addition, a specific AKT inhibitor LY294002 was utilized to examine the correlation between the expression of TRIM37 and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	124-127
30240165-5	2018	Moreover, the mechanism studies also demonstrate that Bi2 S3 -Tween 20@LY294002 potently kills LoVo cancer cells under low-power near-infrared light irradiation, by downregulating the expression of heat shock protein 70 (HSP70) so as to increase the sensitivity of tumor cell hyperthermia and activating BAX/BAK-regulated mitochondrial apoptosis pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	heat shock protein family A (Hsp70) member 4	Homo sapiens	198-219
30464533-10	2018	Additionally, the synergistic effect between LY294002 and cisplatin to suppress the proliferation of Hep-2 might not be from GLUT-1, Akt, PI3k and HIF-1alpha; the synergistic effect between GLUT-1 siRNA and cisplatin to suppress the proliferation of Hep-2 might not be from GLUT-1, Akt and PI3k and might be more or less related to HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	solute carrier family 2 member 1	Homo sapiens	190-196
30464533-10	2018	Additionally, the synergistic effect between LY294002 and cisplatin to suppress the proliferation of Hep-2 might not be from GLUT-1, Akt, PI3k and HIF-1alpha; the synergistic effect between GLUT-1 siRNA and cisplatin to suppress the proliferation of Hep-2 might not be from GLUT-1, Akt and PI3k and might be more or less related to HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	solute carrier family 2 member 1	Homo sapiens	190-196
30464533-10	2018	Additionally, the synergistic effect between LY294002 and cisplatin to suppress the proliferation of Hep-2 might not be from GLUT-1, Akt, PI3k and HIF-1alpha; the synergistic effect between GLUT-1 siRNA and cisplatin to suppress the proliferation of Hep-2 might not be from GLUT-1, Akt and PI3k and might be more or less related to HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	282-285
30464533-10	2018	Additionally, the synergistic effect between LY294002 and cisplatin to suppress the proliferation of Hep-2 might not be from GLUT-1, Akt, PI3k and HIF-1alpha; the synergistic effect between GLUT-1 siRNA and cisplatin to suppress the proliferation of Hep-2 might not be from GLUT-1, Akt and PI3k and might be more or less related to HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	332-342
30585261-11	2018	Akt activation was inhibited the PI3K inhibitors LY294002 and Wortmannin, resulting in the inhibition of cell viability and increase of cytochrome c release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	0-3
30585261-11	2018	Akt activation was inhibited the PI3K inhibitors LY294002 and Wortmannin, resulting in the inhibition of cell viability and increase of cytochrome c release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	cytochrome c, somatic	Homo sapiens	136-148
30464533-6	2018	GLUT-1 siRNA, LY294002 and cisplatin effectively inhibited the mRNA expressions and protein expressions of GLUT-1, Akt, PI3k and HIF-1alpha in Hep-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	solute carrier family 2 member 1	Homo sapiens	107-113
30464533-6	2018	GLUT-1 siRNA, LY294002 and cisplatin effectively inhibited the mRNA expressions and protein expressions of GLUT-1, Akt, PI3k and HIF-1alpha in Hep-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	115-118
30464533-6	2018	GLUT-1 siRNA, LY294002 and cisplatin effectively inhibited the mRNA expressions and protein expressions of GLUT-1, Akt, PI3k and HIF-1alpha in Hep-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
30464533-9	2018	Conclusion: This study showed that inhibiting GLUT-1, by a GLUT-1 siRNA and inhibiting PI3K/Akt by Ly294002, could suppress the proliferation of Hep-2 alone and together with cisplatin synergistically, which demonstrated the potentials to treat laryngeal carcinoma in the future therapy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	solute carrier family 2 member 1	Homo sapiens	46-52
30464533-9	2018	Conclusion: This study showed that inhibiting GLUT-1, by a GLUT-1 siRNA and inhibiting PI3K/Akt by Ly294002, could suppress the proliferation of Hep-2 alone and together with cisplatin synergistically, which demonstrated the potentials to treat laryngeal carcinoma in the future therapy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	AKT serine/threonine kinase 1	Homo sapiens	92-95
30240165-5	2018	Moreover, the mechanism studies also demonstrate that Bi2 S3 -Tween 20@LY294002 potently kills LoVo cancer cells under low-power near-infrared light irradiation, by downregulating the expression of heat shock protein 70 (HSP70) so as to increase the sensitivity of tumor cell hyperthermia and activating BAX/BAK-regulated mitochondrial apoptosis pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	heat shock protein family A (Hsp70) member 4	Homo sapiens	221-226
30240165-5	2018	Moreover, the mechanism studies also demonstrate that Bi2 S3 -Tween 20@LY294002 potently kills LoVo cancer cells under low-power near-infrared light irradiation, by downregulating the expression of heat shock protein 70 (HSP70) so as to increase the sensitivity of tumor cell hyperthermia and activating BAX/BAK-regulated mitochondrial apoptosis pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	BCL2 associated X, apoptosis regulator	Homo sapiens	304-307
30240165-5	2018	Moreover, the mechanism studies also demonstrate that Bi2 S3 -Tween 20@LY294002 potently kills LoVo cancer cells under low-power near-infrared light irradiation, by downregulating the expression of heat shock protein 70 (HSP70) so as to increase the sensitivity of tumor cell hyperthermia and activating BAX/BAK-regulated mitochondrial apoptosis pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	BCL2 antagonist/killer 1	Homo sapiens	308-311
30191639-7	2018	Therefore, both the IGF1Rbeta inhibitor (AG1024) and the PI3K inhibitor (LY294002) or AKT inactivation with MK2206 lower the cellular level of Snail1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	snail family transcriptional repressor 1	Homo sapiens	143-149
30519268-7	2018	In addition, our results also indicated that 6-G could upregulate the expression of PI3K and p-Akt and that LY294002, a blocking agent of PI3K/Akt signaling pathway, could nullify the protecting role of 6-G. Our experimental results showed that 6-G could inhibit I/R-induced inflammatory response through the activation of the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Rattus norvegicus	143-146
30519268-7	2018	In addition, our results also indicated that 6-G could upregulate the expression of PI3K and p-Akt and that LY294002, a blocking agent of PI3K/Akt signaling pathway, could nullify the protecting role of 6-G. Our experimental results showed that 6-G could inhibit I/R-induced inflammatory response through the activation of the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Rattus norvegicus	143-146
30089248-11	2018	Furthermore, compared with si-ADAMTS9-AS2 group, treatment of an PI3K inhibitor LY294002 markedly reversed the effects of suppression of ADAMTS9-AS2 alone on SGC-7901 cells by inhibiting cell viability, colony-forming ability, migration, invasion, and increasing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	ADAM metallopeptidase with thrombospondin type 1 motif 9	Homo sapiens	30-37
30358169-6	2018	This 14-3-3zeta-HBx interaction was partly impaired when Akt signaling transduction was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	5-15
29322615-13	2018	We also found that VO-OHpic (PTEN inhibitor) could counteract Abeta-induced neuronal damage, and LY294002 (AKT inhibitor) suppressed the protective effect of melatonin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	107-110
30089248-11	2018	Furthermore, compared with si-ADAMTS9-AS2 group, treatment of an PI3K inhibitor LY294002 markedly reversed the effects of suppression of ADAMTS9-AS2 alone on SGC-7901 cells by inhibiting cell viability, colony-forming ability, migration, invasion, and increasing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	ADAM metallopeptidase with thrombospondin type 1 motif 9	Homo sapiens	137-144
30536350-9	2018	LY294002 induction remarkably reverses the protective role of Clobenpropit in neuronal apoptosis, manifesting as downregulated PI3K and p-AKT after LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	138-141
29286212-7	2018	LY294002 were used to inhibit PI3 K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	36-39
30358169-6	2018	This 14-3-3zeta-HBx interaction was partly impaired when Akt signaling transduction was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	X protein	Hepatitis B virus	16-19
30144329-6	2018	IGF-1 downregulated FoxO1 and involucrin but upregulated p-Akt expression in HPKs, which was blocked by pretreatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	insulin like growth factor 1	Homo sapiens	0-5
29932233-7	2018	LY294002, a pharmacological inhibitor of Phosphoinositide 3-kinase (PI3K) reversed the above effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	41-66
30144329-6	2018	IGF-1 downregulated FoxO1 and involucrin but upregulated p-Akt expression in HPKs, which was blocked by pretreatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	forkhead box O1	Homo sapiens	20-25
30144329-6	2018	IGF-1 downregulated FoxO1 and involucrin but upregulated p-Akt expression in HPKs, which was blocked by pretreatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Homo sapiens	59-62
29932247-7	2018	Moreover, expression of Nrf2 HupA-mediated was significant attenuated by AKT inhibitor (LY294002), p38 MAPK inhibitor (SB202190) and ERK inhibitor (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	nuclear factor, erythroid derived 2, like 2	Mus musculus	24-28
30091803-10	2018	A specific inhibitor of phosphoinositide 3-kinase, LY294002, reduced LGI3-induced expression of differentiation markers in HaCaT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	leucine rich repeat LGI family member 3	Homo sapiens	69-73
30173054-7	2018	Additionally, a pharmacological inhibitor of PI3K/AKT, LY294002, also restrained the phosphorylation levels of IkappaBalpha and NF-kappaB p65 and thereby decreased the expression of pro-inflammatory cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	thymoma viral proto-oncogene 1	Mus musculus	50-53
30173054-7	2018	Additionally, a pharmacological inhibitor of PI3K/AKT, LY294002, also restrained the phosphorylation levels of IkappaBalpha and NF-kappaB p65 and thereby decreased the expression of pro-inflammatory cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	111-123
30173054-7	2018	Additionally, a pharmacological inhibitor of PI3K/AKT, LY294002, also restrained the phosphorylation levels of IkappaBalpha and NF-kappaB p65 and thereby decreased the expression of pro-inflammatory cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	128-137
30173054-7	2018	Additionally, a pharmacological inhibitor of PI3K/AKT, LY294002, also restrained the phosphorylation levels of IkappaBalpha and NF-kappaB p65 and thereby decreased the expression of pro-inflammatory cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	138-141
29932247-7	2018	Moreover, expression of Nrf2 HupA-mediated was significant attenuated by AKT inhibitor (LY294002), p38 MAPK inhibitor (SB202190) and ERK inhibitor (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	thymoma viral proto-oncogene 1	Mus musculus	73-76
29932233-10	2018	LY294002 also reversed the elevated SOX2 and NANOG expression induced by IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	SRY-box transcription factor 2	Homo sapiens	36-40
29932233-10	2018	LY294002 also reversed the elevated SOX2 and NANOG expression induced by IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Nanog homeobox	Homo sapiens	45-50
29932233-10	2018	LY294002 also reversed the elevated SOX2 and NANOG expression induced by IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 beta	Homo sapiens	73-81
29435871-7	2018	PI3K-Akt pathway inhibitors, Akti-1/2 and LY294002, reduced PFKFB3 gene induction by PHA, as well as Fru-2,6-P2 and lactate production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	60-66
30409306-5	2018	Knock down of CD44v4/CD44v6 (by siRNA) or inactivation of MAPK/PI3K pathways using specific PD98059/LY294002 was achieved for in vitro analysis of chemoresistance and invasion/migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	mitogen-activated protein kinase 3	Homo sapiens	58-62
30498333-13	2018	However, the effects mediated by asiatic acid on glycometabolism and GLUT4 translocation were reversed by the administration of LY294002, the Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	solute carrier family 2 member 4	Rattus norvegicus	69-74
30384400-7	2018	Similar effectswere observed in the BMDM isolated from CCR5 knockout mice compared with wild type control.RANTES treatment promptly enhanced membrane glucose transporter 1 (GLUT1) expression,glucose uptake as well as phosphorylation of AKT on Thr308, Ser473 within min and has prolongedeffect on phosphorylation of AMP-activated protein kinase (AMPK) on Thr172, which wereabrogated by maraviroc, CCR5 siRNA or phospholipase C (PLC) inhibitor in RAW264.7 cells.Inhibition of PI3K and AMPK by LY294002 and Compound C significantly suppress RANTES-stimulatedmacrophage glucose uptake and migration, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	491-499	chemokine (C-C motif) ligand 5	Mus musculus	106-112
30498333-13	2018	However, the effects mediated by asiatic acid on glycometabolism and GLUT4 translocation were reversed by the administration of LY294002, the Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	AKT serine/threonine kinase 1	Rattus norvegicus	142-145
30402135-16	2018	LY294002 and BSYX evidently downregulated the proteins levels of FSHR, p-Akt/Akt, Gankyrin, and cyclinD1 and upregulated the expression of HIF-alpha protein, and FSH was on the opposite.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	follicle stimulating hormone receptor	Homo sapiens	65-69
30377685-6	2018	The effect of icaritin on the proliferation of MG63 cells was significantly decreased by pretreating the cells with U0126 (an ERK signaling pathway blocker) and LY294002 (an AKT signaling pathway blocker), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	AKT serine/threonine kinase 1	Homo sapiens	174-177
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	AKT serine/threonine kinase 1	Homo sapiens	79-82
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	AKT serine/threonine kinase 1	Homo sapiens	136-139
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	interleukin 1 alpha	Homo sapiens	198-206
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	interleukin 6	Homo sapiens	208-212
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	tumor necrosis factor	Homo sapiens	218-227
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	mannose receptor C-type 1	Homo sapiens	297-302
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	arginase 1	Homo sapiens	304-309
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	resistin like beta	Homo sapiens	311-317
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	interleukin 10	Homo sapiens	323-328
30349447-14	2018	Further, 3,5-diCQA enhanced the phosphorylation levels of PI3K and Akt in H9C2 cells directly, while LY294002 attenuated the effects of 3,5-diCQA on PI3K and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Rattus norvegicus	158-161
30402135-16	2018	LY294002 and BSYX evidently downregulated the proteins levels of FSHR, p-Akt/Akt, Gankyrin, and cyclinD1 and upregulated the expression of HIF-alpha protein, and FSH was on the opposite.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	73-76
30297636-5	2018	The cultured J774 cells, with or without lipopolysaccharide (LPS), were treated with Ly294002 (Ly), which is an inhibitor of phosphoinositide 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-87	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	125-150
30297636-5	2018	The cultured J774 cells, with or without lipopolysaccharide (LPS), were treated with Ly294002 (Ly), which is an inhibitor of phosphoinositide 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	125-150
30402135-16	2018	LY294002 and BSYX evidently downregulated the proteins levels of FSHR, p-Akt/Akt, Gankyrin, and cyclinD1 and upregulated the expression of HIF-alpha protein, and FSH was on the opposite.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	77-80
30402135-16	2018	LY294002 and BSYX evidently downregulated the proteins levels of FSHR, p-Akt/Akt, Gankyrin, and cyclinD1 and upregulated the expression of HIF-alpha protein, and FSH was on the opposite.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	proteasome 26S subunit, non-ATPase 10	Homo sapiens	82-90
30402135-16	2018	LY294002 and BSYX evidently downregulated the proteins levels of FSHR, p-Akt/Akt, Gankyrin, and cyclinD1 and upregulated the expression of HIF-alpha protein, and FSH was on the opposite.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin D1	Homo sapiens	96-104
30119250-14	2018	Finally, blocking PI3K/AKT pathway by using LY294002 eliminated the myocardioprotective effects of miR-208b.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
30107164-9	2018	The combination of resveratrol and the PI3K inhibitor LY294002 had a synergistic effect on the inhibition of Akt phosphorylation and TLR4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	109-112
30107164-9	2018	The combination of resveratrol and the PI3K inhibitor LY294002 had a synergistic effect on the inhibition of Akt phosphorylation and TLR4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	toll like receptor 4	Homo sapiens	133-137
30120922-7	2018	Furthermore, phosphatidylinositol 3-kinase inhibitor LY294002 decreased isoprenaline-induced UCP1 mRNA levels in the early phase of beige adipocyte differentiation and p-synephrine-induced UCP1 mRNA levels in fully differentiated beige adipocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	93-97
30120922-7	2018	Furthermore, phosphatidylinositol 3-kinase inhibitor LY294002 decreased isoprenaline-induced UCP1 mRNA levels in the early phase of beige adipocyte differentiation and p-synephrine-induced UCP1 mRNA levels in fully differentiated beige adipocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	189-193
30119206-4	2018	We found LY294002 obviously restrained cell proliferation in dose-dependent and time-dependent manners by inhibiting PI3K/Akt/mTOR/p70S6K signaling pathway, whereas triggered mTORC2-medicated phosphorylation of Akt (Ser473)/PRAS40 (Thr246) in ECa109 and EC9706 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT1 substrate 1	Homo sapiens	224-230
30119206-5	2018	Stable knockdown of Rictor by shRNA enhanced the inhibitory effects of LY294002 on cell proliferative, migration and colony formation, as well as promoted its effects on cell cycle arrest and cell apoptosis in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	RPTOR independent companion of MTOR complex 2	Homo sapiens	20-26
30119206-0	2018	Down-regulation of Rictor enhances cell sensitivity to PI3K inhibitor LY294002 by blocking mTORC2-medicated phosphorylation of Akt/PRAS40 in esophageal squamous cell carcinoma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	RPTOR independent companion of MTOR complex 2	Homo sapiens	19-25
30119206-0	2018	Down-regulation of Rictor enhances cell sensitivity to PI3K inhibitor LY294002 by blocking mTORC2-medicated phosphorylation of Akt/PRAS40 in esophageal squamous cell carcinoma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	CREB regulated transcription coactivator 2	Mus musculus	91-97
30119206-0	2018	Down-regulation of Rictor enhances cell sensitivity to PI3K inhibitor LY294002 by blocking mTORC2-medicated phosphorylation of Akt/PRAS40 in esophageal squamous cell carcinoma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Homo sapiens	127-130
30119206-0	2018	Down-regulation of Rictor enhances cell sensitivity to PI3K inhibitor LY294002 by blocking mTORC2-medicated phosphorylation of Akt/PRAS40 in esophageal squamous cell carcinoma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT1 substrate 1	Homo sapiens	131-137
30119206-3	2018	The objective of this study is to evaluate the effects of Rictor knockdown on cell sensitivity to PI3K inhibitor LY294002 in ESCC cells and ESCC xenografts as well as its mechanisms.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	RPTOR independent companion of MTOR complex 2	Homo sapiens	58-64
30119250-14	2018	Finally, blocking PI3K/AKT pathway by using LY294002 eliminated the myocardioprotective effects of miR-208b.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	microRNA 208b	Rattus norvegicus	99-107
30119206-4	2018	We found LY294002 obviously restrained cell proliferation in dose-dependent and time-dependent manners by inhibiting PI3K/Akt/mTOR/p70S6K signaling pathway, whereas triggered mTORC2-medicated phosphorylation of Akt (Ser473)/PRAS40 (Thr246) in ECa109 and EC9706 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	122-125
30119206-4	2018	We found LY294002 obviously restrained cell proliferation in dose-dependent and time-dependent manners by inhibiting PI3K/Akt/mTOR/p70S6K signaling pathway, whereas triggered mTORC2-medicated phosphorylation of Akt (Ser473)/PRAS40 (Thr246) in ECa109 and EC9706 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	mechanistic target of rapamycin kinase	Homo sapiens	126-130
30119206-4	2018	We found LY294002 obviously restrained cell proliferation in dose-dependent and time-dependent manners by inhibiting PI3K/Akt/mTOR/p70S6K signaling pathway, whereas triggered mTORC2-medicated phosphorylation of Akt (Ser473)/PRAS40 (Thr246) in ECa109 and EC9706 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	ribosomal protein S6 kinase B1	Homo sapiens	131-137
30119206-6	2018	Furthermore, stable knockdown of Rictor enhanced the antitumor effects of LY294002 by inhibiting tumor growth and promoting cell apoptosis in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	RPTOR independent companion of MTOR complex 2	Homo sapiens	33-39
30119206-7	2018	Mechanistic assay revealed that knockdown of Rictor could attenuate LY294002-induced phosphorylation of Akt (Ser473)/PRAS40 (Thr246).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	RPTOR independent companion of MTOR complex 2	Homo sapiens	45-51
30119206-7	2018	Mechanistic assay revealed that knockdown of Rictor could attenuate LY294002-induced phosphorylation of Akt (Ser473)/PRAS40 (Thr246).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	104-107
30119206-4	2018	We found LY294002 obviously restrained cell proliferation in dose-dependent and time-dependent manners by inhibiting PI3K/Akt/mTOR/p70S6K signaling pathway, whereas triggered mTORC2-medicated phosphorylation of Akt (Ser473)/PRAS40 (Thr246) in ECa109 and EC9706 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	CREB regulated transcription coactivator 2	Mus musculus	175-181
29956071-6	2018	Significantly, inhibition of PI3K/Akt pathway by Ly294002 attenuated platelet activation and CD40L production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	34-37
30119206-4	2018	We found LY294002 obviously restrained cell proliferation in dose-dependent and time-dependent manners by inhibiting PI3K/Akt/mTOR/p70S6K signaling pathway, whereas triggered mTORC2-medicated phosphorylation of Akt (Ser473)/PRAS40 (Thr246) in ECa109 and EC9706 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	211-214
30032334-8	2018	Furthermore, the process of TM4 cells promoting the proliferation of ADSCs was significantly inhibited by the administration of the PI3K/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	thymoma viral proto-oncogene 1	Mus musculus	137-140
30119206-7	2018	Mechanistic assay revealed that knockdown of Rictor could attenuate LY294002-induced phosphorylation of Akt (Ser473)/PRAS40 (Thr246).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT1 substrate 1	Homo sapiens	117-123
29956071-6	2018	Significantly, inhibition of PI3K/Akt pathway by Ly294002 attenuated platelet activation and CD40L production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	CD40 ligand	Homo sapiens	93-98
29956071-8	2018	Furthermore, the expression of biomarkers that represent the severity of sepsis, such as ICAM-1, VCAM-1, and E-selectin, was also suppressed by Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	intercellular adhesion molecule 1	Homo sapiens	89-95
29956071-8	2018	Furthermore, the expression of biomarkers that represent the severity of sepsis, such as ICAM-1, VCAM-1, and E-selectin, was also suppressed by Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	vascular cell adhesion molecule 1	Homo sapiens	97-103
29956071-8	2018	Furthermore, the expression of biomarkers that represent the severity of sepsis, such as ICAM-1, VCAM-1, and E-selectin, was also suppressed by Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	selectin E	Homo sapiens	109-119
30167941-4	2018	Here SH-SY5Y cells exposed to OGD/R injury in treated with LY294002, ginsenoside Rb1, ginsenoside Rb1+ LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	RB transcriptional corepressor 1	Homo sapiens	98-101
30400057-8	2018	Furthermore, LY294002 and ML385 (inhibitor of PI3K and Nrf2) attenuated Baicalin mediated Nrf2 activation and the ability of facilitates angiogenesis in vivo and ex vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	55-59
30400057-8	2018	Furthermore, LY294002 and ML385 (inhibitor of PI3K and Nrf2) attenuated Baicalin mediated Nrf2 activation and the ability of facilitates angiogenesis in vivo and ex vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
30259565-6	2018	However, the increase in PI3K and P-AKT protein levels and the decrease in Bax, caspase-3, and caspase-9 protein levels induced by NaB treatment were reversed when the cells were pretreated with LY294002 (PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	AKT serine/threonine kinase 1	Bos taurus	36-39
30021868-7	2018	Inhibition of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) by LY294002 suppressed the histamine-induced chemotaxis and activation of Rac GTPases, suggesting that PI3K regulates chemotaxis upstream of Rac activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	14-60
30021868-7	2018	Inhibition of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) by LY294002 suppressed the histamine-induced chemotaxis and activation of Rac GTPases, suggesting that PI3K regulates chemotaxis upstream of Rac activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	Rac family small GTPase 1	Homo sapiens	142-145
29981360-5	2018	When LY294002 (AKT inhibitor) and U0126 (ERK1/2 inhibitor) were treated with avobenzone, the anti-proliferative effect of avobenzone was alleviated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	AKT serine/threonine kinase 1	Homo sapiens	15-18
29894800-9	2018	Treatment with LY294002 also attenuated SiO2-NPs-induced Src phosphorylation, while, JAK2 phosphorylation was not changed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	57-60
29843892-9	2018	LY294002 significantly inhibited follicular activation stimulated by alpha-MEM+ and 100ngmL-1 IGF-1 and reduced pAKT expression in follicles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin-like growth factor I	Ovis aries	94-99
30259565-6	2018	However, the increase in PI3K and P-AKT protein levels and the decrease in Bax, caspase-3, and caspase-9 protein levels induced by NaB treatment were reversed when the cells were pretreated with LY294002 (PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	BCL2 associated X, apoptosis regulator	Homo sapiens	75-78
30259565-6	2018	However, the increase in PI3K and P-AKT protein levels and the decrease in Bax, caspase-3, and caspase-9 protein levels induced by NaB treatment were reversed when the cells were pretreated with LY294002 (PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	caspase 3	Homo sapiens	80-89
30259565-6	2018	However, the increase in PI3K and P-AKT protein levels and the decrease in Bax, caspase-3, and caspase-9 protein levels induced by NaB treatment were reversed when the cells were pretreated with LY294002 (PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	caspase 9	Homo sapiens	95-104
30146261-11	2018	The inhibitor of Akt, LY294002, attenuated the effects of PD on H/R-induced H9c2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Rattus norvegicus	17-20
30241309-12	2018	On the contrary, a specific inhibitor of PI3K, LY294002 not only inhibited TPAE-induced p-Akt/eNOS upregulation but alleviated its anti-apoptotic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Rattus norvegicus	90-93
30258464-9	2018	LY294002, an inhibitor of the Akt pathway, was used to confirm the associated signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	30-33
29940752-8	2018	LY294002 (PI3K/AKT inhibitor, 200 nM) further promoted YWHAZ silencing-induced apoptosis and autophagy in BGC-823 cells, while insulin-like growth factor-1 (IGF-1; PI3K/AKT agonist, 10 ng/ml) had the opposite role.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	15-18
29940752-8	2018	LY294002 (PI3K/AKT inhibitor, 200 nM) further promoted YWHAZ silencing-induced apoptosis and autophagy in BGC-823 cells, while insulin-like growth factor-1 (IGF-1; PI3K/AKT agonist, 10 ng/ml) had the opposite role.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	55-60
29940752-8	2018	LY294002 (PI3K/AKT inhibitor, 200 nM) further promoted YWHAZ silencing-induced apoptosis and autophagy in BGC-823 cells, while insulin-like growth factor-1 (IGF-1; PI3K/AKT agonist, 10 ng/ml) had the opposite role.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 1	Homo sapiens	127-155
29940752-8	2018	LY294002 (PI3K/AKT inhibitor, 200 nM) further promoted YWHAZ silencing-induced apoptosis and autophagy in BGC-823 cells, while insulin-like growth factor-1 (IGF-1; PI3K/AKT agonist, 10 ng/ml) had the opposite role.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 1	Homo sapiens	157-162
29940752-8	2018	LY294002 (PI3K/AKT inhibitor, 200 nM) further promoted YWHAZ silencing-induced apoptosis and autophagy in BGC-823 cells, while insulin-like growth factor-1 (IGF-1; PI3K/AKT agonist, 10 ng/ml) had the opposite role.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	169-172
29964051-11	2018	Ly294002, a phosphatidylinositol 3-kinases (PI3K) inhibitor, was used to identify the underlying mechanisms by which ADSC-derived exosomes promote wound healing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	12-42
29964051-15	2018	However, Ly294002 alleviated these exosome-induced changes, suggesting that exosomes from ADSCs could promote and optimize collagen deposition in vitro and in vivo and further promote wound healing via the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	211-214
30075219-8	2018	However, incubation with LY294002, a specific inhibitor of phosphatidylinositol-3-kinase (PI3K), abolished the effects of DHA, since it increased the expression of cleaved caspase-1 and the production of inflammatory cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	59-88
30195866-7	2018	RESULTS: Pretreatment with L-NAME and LY294002 significantly decreased the LCE-induced NO production, as well as eNOS and Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	122-125
30228782-9	2018	The results of TAE226, U0126 or Ly294002 treatment confirmed an essential role of FMNL3 in activation of the RhoC/FAK pathway and the subsequent promotion of CRC invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	formin like 3	Homo sapiens	82-87
30225216-8	2018	The expression of MMP-2, MMP-9 and VEGF were downregulated in the LY294002 treatment group by Western blot and real-time RT-PCR (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	matrix metallopeptidase 2	Homo sapiens	18-23
30225216-8	2018	The expression of MMP-2, MMP-9 and VEGF were downregulated in the LY294002 treatment group by Western blot and real-time RT-PCR (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	matrix metallopeptidase 9	Homo sapiens	25-30
30225216-8	2018	The expression of MMP-2, MMP-9 and VEGF were downregulated in the LY294002 treatment group by Western blot and real-time RT-PCR (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	vascular endothelial growth factor A	Homo sapiens	35-39
30225216-9	2018	CONCLUSION: LY294002 regulates the function of RECs by reducing the expression of MMP-2, MMP-9, and VEGF in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	matrix metallopeptidase 2	Homo sapiens	82-87
30225216-9	2018	CONCLUSION: LY294002 regulates the function of RECs by reducing the expression of MMP-2, MMP-9, and VEGF in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	matrix metallopeptidase 9	Homo sapiens	89-94
30225216-9	2018	CONCLUSION: LY294002 regulates the function of RECs by reducing the expression of MMP-2, MMP-9, and VEGF in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	vascular endothelial growth factor A	Homo sapiens	100-104
29402343-10	2018	The increased phosphorylations of PI3K, AKT, and mTOR, and the upregulation of CXCL8 induced by miR-204 suppression were all abolished by the addition of LY294002 and AZD8055 (inhibitors of PI3K/AKT and mTOR, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Homo sapiens	40-43
29402343-10	2018	The increased phosphorylations of PI3K, AKT, and mTOR, and the upregulation of CXCL8 induced by miR-204 suppression were all abolished by the addition of LY294002 and AZD8055 (inhibitors of PI3K/AKT and mTOR, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	mechanistic target of rapamycin kinase	Homo sapiens	49-53
29402343-10	2018	The increased phosphorylations of PI3K, AKT, and mTOR, and the upregulation of CXCL8 induced by miR-204 suppression were all abolished by the addition of LY294002 and AZD8055 (inhibitors of PI3K/AKT and mTOR, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	C-X-C motif chemokine ligand 8	Homo sapiens	79-84
29402343-10	2018	The increased phosphorylations of PI3K, AKT, and mTOR, and the upregulation of CXCL8 induced by miR-204 suppression were all abolished by the addition of LY294002 and AZD8055 (inhibitors of PI3K/AKT and mTOR, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	microRNA 204	Homo sapiens	96-103
29402343-10	2018	The increased phosphorylations of PI3K, AKT, and mTOR, and the upregulation of CXCL8 induced by miR-204 suppression were all abolished by the addition of LY294002 and AZD8055 (inhibitors of PI3K/AKT and mTOR, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Homo sapiens	195-198
29402343-10	2018	The increased phosphorylations of PI3K, AKT, and mTOR, and the upregulation of CXCL8 induced by miR-204 suppression were all abolished by the addition of LY294002 and AZD8055 (inhibitors of PI3K/AKT and mTOR, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	mechanistic target of rapamycin kinase	Homo sapiens	203-207
30228782-9	2018	The results of TAE226, U0126 or Ly294002 treatment confirmed an essential role of FMNL3 in activation of the RhoC/FAK pathway and the subsequent promotion of CRC invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	ras homolog family member C	Homo sapiens	109-113
30228782-9	2018	The results of TAE226, U0126 or Ly294002 treatment confirmed an essential role of FMNL3 in activation of the RhoC/FAK pathway and the subsequent promotion of CRC invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	protein tyrosine kinase 2	Homo sapiens	114-117
30025893-8	2018	Inhibition of PI3K/Akt signaling with LY294002 similarly increased CREB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	19-22
30208576-6	2018	Inhibition of PI3K/AKT/mTOR signaling pathway in the DU-145 cells by employing inhibitor LY294002 (10 muM) or rapamycin (20 nM) effectively attenuated AAP-H-induced phosphorylation of AKT and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	AKT serine/threonine kinase 1	Homo sapiens	19-22
30208576-6	2018	Inhibition of PI3K/AKT/mTOR signaling pathway in the DU-145 cells by employing inhibitor LY294002 (10 muM) or rapamycin (20 nM) effectively attenuated AAP-H-induced phosphorylation of AKT and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	mechanistic target of rapamycin kinase	Homo sapiens	23-27
30208576-6	2018	Inhibition of PI3K/AKT/mTOR signaling pathway in the DU-145 cells by employing inhibitor LY294002 (10 muM) or rapamycin (20 nM) effectively attenuated AAP-H-induced phosphorylation of AKT and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	serpin family F member 2	Homo sapiens	151-154
30208576-6	2018	Inhibition of PI3K/AKT/mTOR signaling pathway in the DU-145 cells by employing inhibitor LY294002 (10 muM) or rapamycin (20 nM) effectively attenuated AAP-H-induced phosphorylation of AKT and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	AKT serine/threonine kinase 1	Homo sapiens	184-187
30208576-6	2018	Inhibition of PI3K/AKT/mTOR signaling pathway in the DU-145 cells by employing inhibitor LY294002 (10 muM) or rapamycin (20 nM) effectively attenuated AAP-H-induced phosphorylation of AKT and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	mechanistic target of rapamycin kinase	Homo sapiens	192-196
30025893-8	2018	Inhibition of PI3K/Akt signaling with LY294002 similarly increased CREB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	cAMP responsive element binding protein 1	Homo sapiens	67-71
30310502-10	2018	Additionally, pretreatment with LY294002 obviously blocked HPV-16 E6- and E7-induced Snail1, Slug, and Twist1 protein expression in A549 and NCI-H460 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	snail family transcriptional repressor 1	Homo sapiens	85-91
30201908-7	2018	Furthermore, TSG activated the phosphoinosmde-3-kinase/protein kinase B (also known as PI3K/Akt) pathway, and blocking this pathway by the inhibitor LY-294002 could impair TSG"s functions in relation to the MC3T3-E1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-158	thymoma viral proto-oncogene 1	Mus musculus	92-95
30310502-10	2018	Additionally, pretreatment with LY294002 obviously blocked HPV-16 E6- and E7-induced Snail1, Slug, and Twist1 protein expression in A549 and NCI-H460 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	snail family transcriptional repressor 2	Homo sapiens	93-97
30310502-10	2018	Additionally, pretreatment with LY294002 obviously blocked HPV-16 E6- and E7-induced Snail1, Slug, and Twist1 protein expression in A549 and NCI-H460 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	twist family bHLH transcription factor 1	Homo sapiens	103-109
29908183-10	2018	LY294002, an inhibitor of PI3K/Akt signaling, attenuated the enhancement of Nrf2 protein and protective effect of MIF in OGD-treated cochlear cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	31-34
29908183-10	2018	LY294002, an inhibitor of PI3K/Akt signaling, attenuated the enhancement of Nrf2 protein and protective effect of MIF in OGD-treated cochlear cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
29913144-8	2018	4PBA increased ERK2 phosphorylation levels, which could be inhibited by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	mitogen-activated protein kinase 1	Homo sapiens	15-19
29908183-10	2018	LY294002, an inhibitor of PI3K/Akt signaling, attenuated the enhancement of Nrf2 protein and protective effect of MIF in OGD-treated cochlear cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	macrophage migration inhibitory factor	Homo sapiens	114-117
30186504-12	2018	The phosphorylation of Akt was significantly increased following transfection with miR-126 mimics in stimulated cells, however the signaling activation was abrogated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
30323976-6	2018	Finally, we showed that LY294002, an inhibitor of PI3K/Akt signaling, attenuated the effects of mutant RasGRP3 on thyroid cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	55-58
30323976-6	2018	Finally, we showed that LY294002, an inhibitor of PI3K/Akt signaling, attenuated the effects of mutant RasGRP3 on thyroid cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	RAS guanyl releasing protein 3	Homo sapiens	103-110
29709078-5	2018	We tested our hypothesis by determining the influence of dietary TiO2 NPs (for 72 h) and, separately, of two Akt/Tor pathway inhibitors (LY294002 and rapamycin) on expression of Akt/Tor signaling pathway genes and proteins in the silk glands.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	RAC serine/threonine-protein kinase	Bombyx mori	109-112
29709078-5	2018	We tested our hypothesis by determining the influence of dietary TiO2 NPs (for 72 h) and, separately, of two Akt/Tor pathway inhibitors (LY294002 and rapamycin) on expression of Akt/Tor signaling pathway genes and proteins in the silk glands.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	RAC serine/threonine-protein kinase	Bombyx mori	178-181
29709078-9	2018	LY294002 treatments led to inhibition of Akt phosphorylation and its downstream proteins and rapamycin treatments similarly inhibited the phosphorylation of Tor-linked downstream proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	RAC serine/threonine-protein kinase	Bombyx mori	41-44
30210614-8	2018	However, pretreatment with LY294002 significantly inhibited the phosphorylation of Akt, decreased HO-1 levels, aggravated mitochondrial fragmentation, increased Fis1 mRNA and protein levels, and reversed the above protective effects of CORM2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	83-86
30210614-8	2018	However, pretreatment with LY294002 significantly inhibited the phosphorylation of Akt, decreased HO-1 levels, aggravated mitochondrial fragmentation, increased Fis1 mRNA and protein levels, and reversed the above protective effects of CORM2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	heme oxygenase 1	Rattus norvegicus	98-102
30210614-8	2018	However, pretreatment with LY294002 significantly inhibited the phosphorylation of Akt, decreased HO-1 levels, aggravated mitochondrial fragmentation, increased Fis1 mRNA and protein levels, and reversed the above protective effects of CORM2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	fission, mitochondrial 1	Rattus norvegicus	161-165
30186504-12	2018	The phosphorylation of Akt was significantly increased following transfection with miR-126 mimics in stimulated cells, however the signaling activation was abrogated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	microRNA 126b	Rattus norvegicus	83-90
29956736-11	2018	Treatment with 5 microM LY294002 produced minimal anti-proliferative effects on human PASMCs and barely induced cellular apoptosis and caspase-3 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	caspase 3	Homo sapiens	135-144
30547894-7	2018	Using the PI3K inhibitor, LY294002, we revealed that AKT is a key regulator in the inhibitory mechanism of morin against PDGF-induced proliferation of VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	53-56
29845292-9	2018	In addition, inhibition of PI3K/Akt signaling activity by treatment with LY294002 markedly reversed the protective effect of EPO on the AAC-induced MF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Rattus norvegicus	32-35
29845292-9	2018	In addition, inhibition of PI3K/Akt signaling activity by treatment with LY294002 markedly reversed the protective effect of EPO on the AAC-induced MF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	erythropoietin	Rattus norvegicus	125-128
29956736-12	2018	However, co-administration of 10 mM DCA with LY294002 significantly decreased the cell proliferation index and induced cell apoptosis and caspase-3 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	caspase 3	Homo sapiens	138-147
29956736-13	2018	The combined administration of LY294002 with DCA significantly decreased lactate concentration, promoted the depolarisation of the DeltaPsim and repressed HIF-1alpha upregulation and HK-2 activation in PASMCs treated with PDGF, which was attributed to the potentiation of DCA-induced PDK-1 inhibition by LY294002 via blockade of the Akt/GSK-3beta/HIF-1alpha signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	155-165
29956736-13	2018	The combined administration of LY294002 with DCA significantly decreased lactate concentration, promoted the depolarisation of the DeltaPsim and repressed HIF-1alpha upregulation and HK-2 activation in PASMCs treated with PDGF, which was attributed to the potentiation of DCA-induced PDK-1 inhibition by LY294002 via blockade of the Akt/GSK-3beta/HIF-1alpha signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	hexokinase 2	Homo sapiens	183-187
29956736-13	2018	The combined administration of LY294002 with DCA significantly decreased lactate concentration, promoted the depolarisation of the DeltaPsim and repressed HIF-1alpha upregulation and HK-2 activation in PASMCs treated with PDGF, which was attributed to the potentiation of DCA-induced PDK-1 inhibition by LY294002 via blockade of the Akt/GSK-3beta/HIF-1alpha signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	pyruvate dehydrogenase kinase 1	Homo sapiens	284-289
29956736-13	2018	The combined administration of LY294002 with DCA significantly decreased lactate concentration, promoted the depolarisation of the DeltaPsim and repressed HIF-1alpha upregulation and HK-2 activation in PASMCs treated with PDGF, which was attributed to the potentiation of DCA-induced PDK-1 inhibition by LY294002 via blockade of the Akt/GSK-3beta/HIF-1alpha signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	333-336
29956736-13	2018	The combined administration of LY294002 with DCA significantly decreased lactate concentration, promoted the depolarisation of the DeltaPsim and repressed HIF-1alpha upregulation and HK-2 activation in PASMCs treated with PDGF, which was attributed to the potentiation of DCA-induced PDK-1 inhibition by LY294002 via blockade of the Akt/GSK-3beta/HIF-1alpha signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	glycogen synthase kinase 3 beta	Homo sapiens	337-346
29956736-13	2018	The combined administration of LY294002 with DCA significantly decreased lactate concentration, promoted the depolarisation of the DeltaPsim and repressed HIF-1alpha upregulation and HK-2 activation in PASMCs treated with PDGF, which was attributed to the potentiation of DCA-induced PDK-1 inhibition by LY294002 via blockade of the Akt/GSK-3beta/HIF-1alpha signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	347-357
29663365-8	2018	Moreover, inhibition of PI3K and MAPK using LY294002, U0126, or SP600125, in addition to myricetin treatment, effectively suppressed cell proliferation compared to treatment with myricetin or each inhibitor alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	mitogen-activated protein kinase 1	Canis lupus familiaris	33-37
29636230-10	2018	Furthermore, p-PI3K, p-Akt, and p-GSK3beta expressions were significantly increased after SX treatment, while they were all reduced after administration of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	AKT serine/threonine kinase 1	Homo sapiens	23-26
29663377-13	2018	Besides, the neuroprotective effect of UBIAD1 was correlated with the PI3K/AKT pathway, which was demonstrated using the PI3K inhibitor LY294002 and perifosion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	UbiA prenyltransferase domain containing 1	Mus musculus	39-45
29636230-10	2018	Furthermore, p-PI3K, p-Akt, and p-GSK3beta expressions were significantly increased after SX treatment, while they were all reduced after administration of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	glycogen synthase kinase 3 beta	Homo sapiens	34-42
29749659-10	2018	Expressions of AKT1 and AKT2 were decreased in the GCs under exposure to bicalutamide or LY294002 (P <= 0.05 vs R1881).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	AKT serine/threonine kinase 1	Homo sapiens	15-19
29749659-10	2018	Expressions of AKT1 and AKT2 were decreased in the GCs under exposure to bicalutamide or LY294002 (P <= 0.05 vs R1881).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	AKT serine/threonine kinase 2	Homo sapiens	24-28
29663377-13	2018	Besides, the neuroprotective effect of UBIAD1 was correlated with the PI3K/AKT pathway, which was demonstrated using the PI3K inhibitor LY294002 and perifosion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	thymoma viral proto-oncogene 1	Mus musculus	75-78
29749659-11	2018	AKT1, AKT2, and AKT3 showed decreased rates of expressions in the LY294002 + bicalutamide group (P <= 0.05 vs R1881).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	0-4
29749659-11	2018	AKT1, AKT2, and AKT3 showed decreased rates of expressions in the LY294002 + bicalutamide group (P <= 0.05 vs R1881).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 2	Homo sapiens	6-10
30066869-10	2018	Consistently, PI3K inhibitor LY294002 exerted the opposite effect to IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	insulin-like growth factor 1	Rattus norvegicus	69-74
29749659-11	2018	AKT1, AKT2, and AKT3 showed decreased rates of expressions in the LY294002 + bicalutamide group (P <= 0.05 vs R1881).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 3	Homo sapiens	16-20
30460698-3	2018	The same inhibiting effect is shown in platelets pretreated with LY294002, an inhibitor of phosphatidylinositol 3 kinase (PI3K), or with MK2206, an inhibitor of protein kinase B (AKT), suggesting that AMPK is downstream of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	201-205
30460698-3	2018	The same inhibiting effect is shown in platelets pretreated with LY294002, an inhibitor of phosphatidylinositol 3 kinase (PI3K), or with MK2206, an inhibitor of protein kinase B (AKT), suggesting that AMPK is downstream of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	232-235
30460698-7	2018	We have demonstrated that AEA stimulates VASP phosphorylation on both thr278 and ser239 that is strongly inhibited by STO-609, LY294002, and MK2206.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	vasodilator stimulated phosphoprotein	Homo sapiens	41-45
30347925-11	2018	Furthermore, the inhibition of PI3K/Akt by LY294002 or that of mTOR by rapamycin augmented LCA-induced autophagy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	36-39
30122991-9	2018	These effects were reversed by the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	35-38
30140630-0	2018	Inhibition of LY294002 in retinal neovascularization via down-regulation the PI3K/AKT-VEGF pathway in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	thymoma viral proto-oncogene 1	Mus musculus	82-85
30140630-0	2018	Inhibition of LY294002 in retinal neovascularization via down-regulation the PI3K/AKT-VEGF pathway in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	vascular endothelial growth factor A	Mus musculus	86-90
30140630-5	2018	HUVECs treating with LY294002 were exposed to hypoxia; the expression of PI3K, AKT and VEGF were examined by Western blot and RT-PCR analyses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	thymoma viral proto-oncogene 1	Mus musculus	79-82
30140630-5	2018	HUVECs treating with LY294002 were exposed to hypoxia; the expression of PI3K, AKT and VEGF were examined by Western blot and RT-PCR analyses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	vascular endothelial growth factor A	Mus musculus	87-91
30140630-8	2018	Intravitreal injection of LY294002 (in the LY294002 treatment group) markedly decreased PI3K/AKT-VEGF expression compared with the OIR-control group by immunohistochemistry, Western blotting and RT-PCR (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	thymoma viral proto-oncogene 1	Mus musculus	93-96
30140630-8	2018	Intravitreal injection of LY294002 (in the LY294002 treatment group) markedly decreased PI3K/AKT-VEGF expression compared with the OIR-control group by immunohistochemistry, Western blotting and RT-PCR (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	vascular endothelial growth factor A	Mus musculus	97-101
30140630-8	2018	Intravitreal injection of LY294002 (in the LY294002 treatment group) markedly decreased PI3K/AKT-VEGF expression compared with the OIR-control group by immunohistochemistry, Western blotting and RT-PCR (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	thymoma viral proto-oncogene 1	Mus musculus	93-96
30140630-8	2018	Intravitreal injection of LY294002 (in the LY294002 treatment group) markedly decreased PI3K/AKT-VEGF expression compared with the OIR-control group by immunohistochemistry, Western blotting and RT-PCR (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	vascular endothelial growth factor A	Mus musculus	97-101
30140630-9	2018	In HUVECs treated with hypoxia, expression of PI3K, AKT and VEGF were downregulated in the hypoxia-LY294002 group (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	thymoma viral proto-oncogene 1	Mus musculus	52-55
30140630-9	2018	In HUVECs treated with hypoxia, expression of PI3K, AKT and VEGF were downregulated in the hypoxia-LY294002 group (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	vascular endothelial growth factor A	Mus musculus	60-64
30140630-10	2018	CONCLUSION: The PI3K inhibitor LY294002 can inhibit RNV by downregulating PI3K, AKT, and VEGF expression in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	thymoma viral proto-oncogene 1	Mus musculus	80-83
30140630-10	2018	CONCLUSION: The PI3K inhibitor LY294002 can inhibit RNV by downregulating PI3K, AKT, and VEGF expression in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	vascular endothelial growth factor A	Mus musculus	89-93
30074018-16	2018	However, combined SC79 and LY294002 treatment abolished SC79-induced p-Akt activity, inhibited anti-apoptotic bcl-2 and promoted anti-apoptotic Bax expression in MCAO mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	71-74
30074018-16	2018	However, combined SC79 and LY294002 treatment abolished SC79-induced p-Akt activity, inhibited anti-apoptotic bcl-2 and promoted anti-apoptotic Bax expression in MCAO mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	B cell leukemia/lymphoma 2	Mus musculus	110-115
30074018-16	2018	However, combined SC79 and LY294002 treatment abolished SC79-induced p-Akt activity, inhibited anti-apoptotic bcl-2 and promoted anti-apoptotic Bax expression in MCAO mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	BCL2-associated X protein	Mus musculus	144-147
30112565-10	2018	WGS and LY294002 (PI3K inhibitor) both remarkably decreased the phosphorylation level of Akt (P &lt; 0.05), down-regulated the protein level of Nrf2 (P &lt; 0.05), increased the content of ROS (P &lt; 0.05), up-regulated the protein level of cleaved Caspase-3 (P &lt; 0.05), and induced apoptosis (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	AKT serine/threonine kinase 1	Homo sapiens	89-92
30112565-10	2018	WGS and LY294002 (PI3K inhibitor) both remarkably decreased the phosphorylation level of Akt (P &lt; 0.05), down-regulated the protein level of Nrf2 (P &lt; 0.05), increased the content of ROS (P &lt; 0.05), up-regulated the protein level of cleaved Caspase-3 (P &lt; 0.05), and induced apoptosis (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	NFE2 like bZIP transcription factor 2	Homo sapiens	144-148
30135500-4	2018	Moreover, BECN1 knockdown and treatment with the autophagy inhibitor, LY294002, during maturation of porcine oocytes in vitro impaired polar body extrusion, disturbed mitochondrial function, triggered the DNA damage response, and induced early apoptosis in porcine oocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	beclin 1	Homo sapiens	10-15
30158850-9	2018	Meanwhile, the small interfering RNA-mediated silencing of PGC1alpha expression and selective inhibitors targeting PI3K/Akt (LY294002 and Akt-iv) could significantly attenuate the neuroprotective effect of compound 22a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	AKT serine/threonine kinase 1	Rattus norvegicus	120-123
30127597-5	2018	LY294002 (LY) (a commonly used PI3K/Akt pathway inhibitor) was injected into the left ventricle at 30 minutes before TBI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	36-39
30112032-10	2018	Furthermore, inhibition of the phosphorylation/activity of Akt by LY294002 and knockdown of phosphatase and tensin homologue (PTEN) with simultaneous upregulation or knockdown of MIST1 revealed that SNAI1 improved the phosphorylation of Akt by inhibiting the expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	59-62
29542683-9	2018	Activation of Nrf2 and CREB could be reversed by co-treatment with a phosphoinositide-3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
29542683-9	2018	Activation of Nrf2 and CREB could be reversed by co-treatment with a phosphoinositide-3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	cAMP responsive element binding protein 1	Rattus norvegicus	23-27
29807220-7	2018	These protective effects of SHK were partially reversed by LY294002, a specific PI3K/Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
30116396-5	2018	A PI3K/AKT inhibitor (LY294002) was added during the mechanistic experiments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Rattus norvegicus	7-10
30116338-6	2018	The expression of Bad protein and Bad mRNA in hippocampus increased while the p-Akt, Bcl-2, Bcl-2 mRNA decreased significantly in the LY294002 treated group compared with the rHuEpo treated group (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	AKT serine/threonine kinase 1	Rattus norvegicus	80-83
30116338-6	2018	The expression of Bad protein and Bad mRNA in hippocampus increased while the p-Akt, Bcl-2, Bcl-2 mRNA decreased significantly in the LY294002 treated group compared with the rHuEpo treated group (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	BCL2, apoptosis regulator	Rattus norvegicus	85-90
30116338-6	2018	The expression of Bad protein and Bad mRNA in hippocampus increased while the p-Akt, Bcl-2, Bcl-2 mRNA decreased significantly in the LY294002 treated group compared with the rHuEpo treated group (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	BCL2, apoptosis regulator	Rattus norvegicus	92-97
30116391-6	2018	The phosphoinositide 3-kinase(PI3K) inhibitor LY294002 was used to investigate the association between PI3K/Akt signaling and Ca2+ influx in the presence of propofol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Rattus norvegicus	108-111
30116391-11	2018	Treatment with LY294002 reversed the propofol-induced decrement of Ca2+ influx on IgE-mediated RBL-2H3 cells, suggesting an association between PI3K/Akt signaling and Ca2+ influx.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Rattus norvegicus	149-152
30116396-11	2018	Mechanistic detections showed that the neuron-favorable and ERS-repressing contributions of NOB were, in part, a result of the activation of the PI3K/AKT pathway, which was validated by a specific PI3K/AKT inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	AKT serine/threonine kinase 1	Rattus norvegicus	150-153
29323710-4	2018	We revealed a significant increase in PI3K/AKT signaling activation which was associated with aberrant bone formation in tibial subchondral bone following destabilizing the medial meniscus (DMM), which was effectively prevented by treatment with PI3K/AKT signaling inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	275-283	thymoma viral proto-oncogene 1	Mus musculus	43-46
29882205-8	2018	LY294002, a PI3K inhibitor, increased the inhibition of invasion and migration mediated by downregulation of MCT1 in CNE2Z cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	solute carrier family 16 member 1	Homo sapiens	109-113
29323710-4	2018	We revealed a significant increase in PI3K/AKT signaling activation which was associated with aberrant bone formation in tibial subchondral bone following destabilizing the medial meniscus (DMM), which was effectively prevented by treatment with PI3K/AKT signaling inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	275-283	thymoma viral proto-oncogene 1	Mus musculus	251-254
29323710-7	2018	However, this MMP-13 induction was attenuated by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	matrix metallopeptidase 13	Mus musculus	14-20
29521449-7	2018	However, the rise in PI3K and p-Akt protein levels, and the decrease in Bax and capase-3 protein levels induced by DHEA treatment were reversed when the cells pretreated with LY294002 (PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	BCL2 associated X, apoptosis regulator	Rattus norvegicus	72-75
29917165-7	2018	Both AKT inhibitor LY294002 and ERK1/2 inhibitor U0126 reduced the ability of angiogenesis and VM formation, as well as mosaic vessel formation induced by HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	5-8
29901104-12	2018	When STAT-1 signaling was inhibited by siRNA, B7-H1 expression on IFN-gamma-treated MSCs decreased and T cell proliferation was restored; however, the expression of B7-H1 did not alter upon treatment with a phosphatidylinositol-3-kinase (PI3K) inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	255-263	signal transducer and activator of transcription 1	Homo sapiens	5-11
29907326-9	2018	Furthermore, the protective effects of FGF21 were prevented by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	fibroblast growth factor 21	Homo sapiens	39-44
29907326-9	2018	Furthermore, the protective effects of FGF21 were prevented by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	68-71
29901139-1	2018	The aim of the present study was to investigate the effects of combination therapy of LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), with hydrogen-rich saline on the proliferation and apoptosis of the non-small cell lung cancer (NSCLC) A549 cell line and the mechanisms underpinning this.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	120-149
29901173-7	2018	Furthermore, the AKT pathway inhibitor LY294002, the ERK pathway inhibitor PD98059 and the TAK1 pathway inhibitor 5Z-7 inhibited the expression of PD-L1 in A549 and H1650 cells, but not in H1975 cells, during the EMT process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	17-20
29901173-7	2018	Furthermore, the AKT pathway inhibitor LY294002, the ERK pathway inhibitor PD98059 and the TAK1 pathway inhibitor 5Z-7 inhibited the expression of PD-L1 in A549 and H1650 cells, but not in H1975 cells, during the EMT process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	CD274 molecule	Homo sapiens	147-152
29917165-7	2018	Both AKT inhibitor LY294002 and ERK1/2 inhibitor U0126 reduced the ability of angiogenesis and VM formation, as well as mosaic vessel formation induced by HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	hepatocyte growth factor	Homo sapiens	155-158
30134819-14	2018	For assessment of downstream signals, the PI3K inhibitor LY294002 and the MEK inhibitor PD98059 suppressed the phosphorylation of AKT and ERK1/2 respectively and abolished the cardioprotective effects induced by IP and NRG-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Rattus norvegicus	130-133
30013652-11	2018	Inhibition of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt pathway by LY294002 augmented juglone-mediated GSK-3beta activity by inhibiting Ser9 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	72-75
30013652-11	2018	Inhibition of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt pathway by LY294002 augmented juglone-mediated GSK-3beta activity by inhibiting Ser9 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	glycogen synthase kinase 3 beta	Homo sapiens	123-132
30003931-9	2018	Moreover, exendin-4 or liraglutide dose-dependently upregulated the level of ANGPTL8 expression and secretion in HepG2 cells, which was eliminated by adding exendin (9-39) and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	angiopoietin like 8	Homo sapiens	77-84
29707793-14	2018	IL-6-induced VEGF secretion was significantly suppressed by a PI3K inhibitor (LY294002) and it was accompanied by inhibited phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	interleukin 6	Homo sapiens	0-4
29707793-14	2018	IL-6-induced VEGF secretion was significantly suppressed by a PI3K inhibitor (LY294002) and it was accompanied by inhibited phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	vascular endothelial growth factor A	Homo sapiens	13-17
29753186-5	2018	As a downstream gene activated by PI3K/Akt signal pathway, we assumed that the targeted depletion of Plk1 could contribute to the chemosensitization induced by synergistic drug interaction of PI3K inhibitor LY294002 together with gemcitabine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	AKT serine/threonine kinase 1	Homo sapiens	39-42
29753186-5	2018	As a downstream gene activated by PI3K/Akt signal pathway, we assumed that the targeted depletion of Plk1 could contribute to the chemosensitization induced by synergistic drug interaction of PI3K inhibitor LY294002 together with gemcitabine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	polo like kinase 1	Homo sapiens	101-105
29753186-7	2018	Both inhibition of PI3K/Akt signal pathway through PI3K inhibitor LY294002 and targeted depletion of Plk1 via recombinant adenoviral shRNA can cause chemosensitization, and the targeted depletion of Plk1 can enhance the chemosensitization of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	24-27
29753186-7	2018	Both inhibition of PI3K/Akt signal pathway through PI3K inhibitor LY294002 and targeted depletion of Plk1 via recombinant adenoviral shRNA can cause chemosensitization, and the targeted depletion of Plk1 can enhance the chemosensitization of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	polo like kinase 1	Homo sapiens	101-105
30134819-14	2018	For assessment of downstream signals, the PI3K inhibitor LY294002 and the MEK inhibitor PD98059 suppressed the phosphorylation of AKT and ERK1/2 respectively and abolished the cardioprotective effects induced by IP and NRG-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	mitogen activated protein kinase 3	Rattus norvegicus	138-144
30134819-14	2018	For assessment of downstream signals, the PI3K inhibitor LY294002 and the MEK inhibitor PD98059 suppressed the phosphorylation of AKT and ERK1/2 respectively and abolished the cardioprotective effects induced by IP and NRG-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	neuregulin 1	Rattus norvegicus	219-224
30097118-12	2018	LY294002 inhibited HCV replication via HO-1 down-regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heme oxygenase 1	Homo sapiens	39-43
29738849-8	2018	LY341495 increased the phosphorylation of Akt in the mPFC, which was blocked by both intra-mPFC injection of WAY100635 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	thymoma viral proto-oncogene 1	Mus musculus	42-45
29660518-6	2018	PI3K inhibitor LY294002 or siRNA targeting Akt (si-Akt) treatment inhibited cell viability, decreased protein levels of ABCB1, ABCC1 and ABCG2, and increased LDH release in A2780/Taxol and SKOV-3/DDP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	ATP binding cassette subfamily B member 1	Homo sapiens	120-125
29660518-6	2018	PI3K inhibitor LY294002 or siRNA targeting Akt (si-Akt) treatment inhibited cell viability, decreased protein levels of ABCB1, ABCC1 and ABCG2, and increased LDH release in A2780/Taxol and SKOV-3/DDP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	ATP binding cassette subfamily C member 1	Homo sapiens	127-132
29660518-6	2018	PI3K inhibitor LY294002 or siRNA targeting Akt (si-Akt) treatment inhibited cell viability, decreased protein levels of ABCB1, ABCC1 and ABCG2, and increased LDH release in A2780/Taxol and SKOV-3/DDP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	137-142
29551335-11	2018	Interestingly, all inhibitors targeting the PI3K/Akt pathway, with the exception of Ly294002, strongly increased IL-1alpha protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	interleukin 1 alpha	Homo sapiens	113-122
30108656-7	2018	The protective effect of DSD-CS could be blocked by the specific PI3K/Akt/eNOS inhibitor LY294002, suggesting that DSD-CS protection of MST1 cell survival from hypoxia was mediated by PI3K/Akt/eNOS pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	AKT serine/threonine kinase 1	Rattus norvegicus	70-73
30108656-7	2018	The protective effect of DSD-CS could be blocked by the specific PI3K/Akt/eNOS inhibitor LY294002, suggesting that DSD-CS protection of MST1 cell survival from hypoxia was mediated by PI3K/Akt/eNOS pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	nitric oxide synthase 3	Rattus norvegicus	74-78
30108656-7	2018	The protective effect of DSD-CS could be blocked by the specific PI3K/Akt/eNOS inhibitor LY294002, suggesting that DSD-CS protection of MST1 cell survival from hypoxia was mediated by PI3K/Akt/eNOS pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	macrophage stimulating 1	Rattus norvegicus	136-140
30108656-7	2018	The protective effect of DSD-CS could be blocked by the specific PI3K/Akt/eNOS inhibitor LY294002, suggesting that DSD-CS protection of MST1 cell survival from hypoxia was mediated by PI3K/Akt/eNOS pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	AKT serine/threonine kinase 1	Rattus norvegicus	189-192
30108656-7	2018	The protective effect of DSD-CS could be blocked by the specific PI3K/Akt/eNOS inhibitor LY294002, suggesting that DSD-CS protection of MST1 cell survival from hypoxia was mediated by PI3K/Akt/eNOS pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	nitric oxide synthase 3	Rattus norvegicus	193-197
29792861-7	2018	Conversely, Akt-mTORC1 inhibitors (RAD001 and LY294002) reduced NLGN3-induced HO1, NOQ1 and GCLC mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	12-15
29792861-7	2018	Conversely, Akt-mTORC1 inhibitors (RAD001 and LY294002) reduced NLGN3-induced HO1, NOQ1 and GCLC mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	CREB regulated transcription coactivator 1	Mus musculus	16-22
29792861-7	2018	Conversely, Akt-mTORC1 inhibitors (RAD001 and LY294002) reduced NLGN3-induced HO1, NOQ1 and GCLC mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	neuroligin 3	Homo sapiens	64-69
29792861-7	2018	Conversely, Akt-mTORC1 inhibitors (RAD001 and LY294002) reduced NLGN3-induced HO1, NOQ1 and GCLC mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	heme oxygenase 1	Homo sapiens	78-81
29792861-7	2018	Conversely, Akt-mTORC1 inhibitors (RAD001 and LY294002) reduced NLGN3-induced HO1, NOQ1 and GCLC mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	glutamate-cysteine ligase catalytic subunit	Homo sapiens	92-96
29969438-9	2018	LINC00312-mediated tumor suppression in TC cells may occur via suppression of activation of the PI3K/Akt signaling pathway and expression of MMP-9, and the role of MMP-9 expression induced by overexpressed LINC00312 or si-LINC00312 could be weakened by LY294002 (PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	253-261	long intergenic non-protein coding RNA 312	Homo sapiens	0-9
29980193-13	2018	Combination treatment with PI3K/AKT pathway inhibitor LY294002 dramatically accelerated the suppression effect of temozolomide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	32-35
29708815-12	2018	The homozygous H2189Y mutation was sensitive to the mTOR inhibitor, everolimus, and the AKT inhibitors AZD5363 and MK-2206 2HCL,and the phosphoinositide 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	mechanistic target of rapamycin kinase	Homo sapiens	52-56
29708815-12	2018	The homozygous H2189Y mutation was sensitive to the mTOR inhibitor, everolimus, and the AKT inhibitors AZD5363 and MK-2206 2HCL,and the phosphoinositide 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	AKT serine/threonine kinase 1	Homo sapiens	88-91
29749435-10	2018	Consistently, the PI3K inhibitor LY294002 synergistically enhanced apoptosis of SKM-1 cells when co-administered with SPAG6 shRNA lentivirus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	sodium voltage-gated channel alpha subunit 4	Homo sapiens	80-85
30058707-14	2018	These effects of ulinastatin were abrogated by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	17-28
30058707-14	2018	These effects of ulinastatin were abrogated by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
29620145-11	2018	Furthermore, pretreatment with LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), significantly impaired the LIF-induced upregulation of p-AKT and Tbx-3 in the marmoset iPSCs, suggesting that the PI3K/Akt signaling pathway is involved in this regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	leukemia inhibitory factor	Callithrix jacchus	118-121
29620145-11	2018	Furthermore, pretreatment with LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), significantly impaired the LIF-induced upregulation of p-AKT and Tbx-3 in the marmoset iPSCs, suggesting that the PI3K/Akt signaling pathway is involved in this regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	T-box transcription factor TBX3	Callithrix jacchus	156-161
29749435-10	2018	Consistently, the PI3K inhibitor LY294002 synergistically enhanced apoptosis of SKM-1 cells when co-administered with SPAG6 shRNA lentivirus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	sperm associated antigen 6	Homo sapiens	118-123
30061946-10	2018	PI3K/AKT inhibitor LY294002 restored DTX-induced caspase-3 activation and Bcl-2 phosphorylation, reversed the effect of CCL2 on the viability of A549 cells and enhanced DTX-induced cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	5-8
29976410-5	2018	The Akt inhibitor LY294002, mTOR inhibitor rapamycin and c-Myc inhibitor 10058-F4 significantly suppressed RPS19 expression and transactivation activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	4-7
29976410-5	2018	The Akt inhibitor LY294002, mTOR inhibitor rapamycin and c-Myc inhibitor 10058-F4 significantly suppressed RPS19 expression and transactivation activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	ribosomal protein S19	Homo sapiens	107-112
29250714-11	2018	The neurological outcome of 2-month-old rats was worsened by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
30061946-10	2018	PI3K/AKT inhibitor LY294002 restored DTX-induced caspase-3 activation and Bcl-2 phosphorylation, reversed the effect of CCL2 on the viability of A549 cells and enhanced DTX-induced cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	caspase 3	Homo sapiens	49-58
30061946-10	2018	PI3K/AKT inhibitor LY294002 restored DTX-induced caspase-3 activation and Bcl-2 phosphorylation, reversed the effect of CCL2 on the viability of A549 cells and enhanced DTX-induced cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	BCL2 apoptosis regulator	Homo sapiens	74-79
30061946-10	2018	PI3K/AKT inhibitor LY294002 restored DTX-induced caspase-3 activation and Bcl-2 phosphorylation, reversed the effect of CCL2 on the viability of A549 cells and enhanced DTX-induced cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	C-C motif chemokine ligand 2	Homo sapiens	120-124
29709474-9	2018	Whereas Akt-mTOR inhibitors (LY294002, AZD2014 and RAD001) abolished KGF-induced Nrf2 activation and anti-OGDR cytoprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	8-11
29668981-11	2018	Similarly, estradiol medium concentrations increased in treated cells compared with non-treated controls, while co-treatment of FSH and IGF-1 with the AKT inhibitor LY294002 reduced CTNNB1 and estradiol production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	insulin like growth factor 1	Bos taurus	136-141
29668981-11	2018	Similarly, estradiol medium concentrations increased in treated cells compared with non-treated controls, while co-treatment of FSH and IGF-1 with the AKT inhibitor LY294002 reduced CTNNB1 and estradiol production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	AKT serine/threonine kinase 1	Bos taurus	151-154
29668981-11	2018	Similarly, estradiol medium concentrations increased in treated cells compared with non-treated controls, while co-treatment of FSH and IGF-1 with the AKT inhibitor LY294002 reduced CTNNB1 and estradiol production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	catenin beta 1	Bos taurus	182-188
29945911-8	2018	Moreover, inhibition of protein kinase B activation with LY294002 rescued the deteriorated effect in aortic banding-treated cardiac-specific CTMP knockout mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	thioesterase superfamily member 4	Mus musculus	141-145
30087712-8	2018	Finally, an activator (740Y-P) and inhibitor (LY294002) of the PI3K/AKT signaling pathway were used in the western blot assays and the following rescue experiments, demonstrating that SNHG1 facilitates cell proliferation and tumorigenicity partly via the PI3K/AKT signaling pathway in PDAC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	68-71
30087712-8	2018	Finally, an activator (740Y-P) and inhibitor (LY294002) of the PI3K/AKT signaling pathway were used in the western blot assays and the following rescue experiments, demonstrating that SNHG1 facilitates cell proliferation and tumorigenicity partly via the PI3K/AKT signaling pathway in PDAC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	small nucleolar RNA host gene 1	Homo sapiens	184-189
30087714-9	2018	What"s more, specific phosphoinositide 3-kinases (PI3K) phosphorylation inhibitor LY294002 potentiated TOFA anti-cancer activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	22-48
29709474-9	2018	Whereas Akt-mTOR inhibitors (LY294002, AZD2014 and RAD001) abolished KGF-induced Nrf2 activation and anti-OGDR cytoprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	mechanistic target of rapamycin kinase	Homo sapiens	12-16
29709474-9	2018	Whereas Akt-mTOR inhibitors (LY294002, AZD2014 and RAD001) abolished KGF-induced Nrf2 activation and anti-OGDR cytoprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	fibroblast growth factor 7	Homo sapiens	69-72
29709474-9	2018	Whereas Akt-mTOR inhibitors (LY294002, AZD2014 and RAD001) abolished KGF-induced Nrf2 activation and anti-OGDR cytoprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
29885663-15	2018	Additionally, the protective roles of rh-Aggf1 were abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	angiogenic factor with G patch and FHA domains 1	Rattus norvegicus	41-46
29790749-6	2018	The anti-inflammatory activity of 8-OHD was attenuated by the HO-1 inhibitor zinc protoporphyrin (Znpp) but augmented by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	thymoma viral proto-oncogene 1	Mus musculus	130-133
29660433-8	2018	This effect was abrogated by LY294002, a PI3K/Akt pathway inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	thymoma viral proto-oncogene 1	Mus musculus	46-49
29678744-11	2018	When PI3K/Akt pathway was blocked by LY294002, the inhibitor of PI3K, the effect of lncARSR on SREBP-2 and HMGCR disappeared.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	thymoma viral proto-oncogene 1	Mus musculus	10-13
29678744-11	2018	When PI3K/Akt pathway was blocked by LY294002, the inhibitor of PI3K, the effect of lncARSR on SREBP-2 and HMGCR disappeared.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	sterol regulatory element binding factor 2	Mus musculus	95-102
29678744-11	2018	When PI3K/Akt pathway was blocked by LY294002, the inhibitor of PI3K, the effect of lncARSR on SREBP-2 and HMGCR disappeared.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	107-112
29610946-12	2018	Ly294002 (an Akt inhibitor) decreased the cell inhibition ability of shZNF84, indicating the involvement of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	13-16
29350822-10	2018	Furthermore, when the SIRT1 and Akt1 activity was inhibited by niacinamide and LY294002, respectively, the neuroprotective effect of resveratrol was remarkably attenuated, which implied that SIRT1 and Akt1 could mediate this process and may be potential molecular targets for intervening rotenone-induced neurotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	sirtuin 1	Rattus norvegicus	22-27
29350822-10	2018	Furthermore, when the SIRT1 and Akt1 activity was inhibited by niacinamide and LY294002, respectively, the neuroprotective effect of resveratrol was remarkably attenuated, which implied that SIRT1 and Akt1 could mediate this process and may be potential molecular targets for intervening rotenone-induced neurotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Rattus norvegicus	32-36
29350822-10	2018	Furthermore, when the SIRT1 and Akt1 activity was inhibited by niacinamide and LY294002, respectively, the neuroprotective effect of resveratrol was remarkably attenuated, which implied that SIRT1 and Akt1 could mediate this process and may be potential molecular targets for intervening rotenone-induced neurotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	sirtuin 1	Rattus norvegicus	191-196
29610946-12	2018	Ly294002 (an Akt inhibitor) decreased the cell inhibition ability of shZNF84, indicating the involvement of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	108-111
29549724-6	2018	LY294002 (20 microM) treatment suppressed the PI3K/Akt signaling and its downstream elements in AA-FLS cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	51-54
29359496-9	2018	Furthermore, the up-regulated expression of PCNA, Cyclin D, Cyclin E and Cyclin A, the increased number of cells in G2 /M and S phase, and the enhanced activation and expression of PI3K and AKT proteins induced by hypoxia and in presence of carvacrol (an agonist of TRPV3), was significantly attenuated by incubation of LY 294002, a specific inhibitor for PI3K/AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	320-329	AKT serine/threonine kinase 1	Rattus norvegicus	190-193
30195330-8	2018	It appeared that treatment with LY294002, which inhibits all Akt isoforms (Akt1, Akt2, Akt3), not only failed to restore the invasive phenotype of melanoma cells but further attenuated their invasive activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	61-64
30195330-8	2018	It appeared that treatment with LY294002, which inhibits all Akt isoforms (Akt1, Akt2, Akt3), not only failed to restore the invasive phenotype of melanoma cells but further attenuated their invasive activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	75-79
30195330-8	2018	It appeared that treatment with LY294002, which inhibits all Akt isoforms (Akt1, Akt2, Akt3), not only failed to restore the invasive phenotype of melanoma cells but further attenuated their invasive activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 2	Homo sapiens	81-85
30195330-8	2018	It appeared that treatment with LY294002, which inhibits all Akt isoforms (Akt1, Akt2, Akt3), not only failed to restore the invasive phenotype of melanoma cells but further attenuated their invasive activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 3	Homo sapiens	87-91
29766336-5	2018	PI3-kinase and MAPK/ERK1/2 were inhibited using LY294002, and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	mitogen-activated protein kinase 3	Homo sapiens	20-26
29549724-9	2018	LY294002 also inhibited osteoclast formation via suppression of PI3K mediated Nfatc1 induction and other downstream elements.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nuclear factor of activated T-cells 1	Rattus norvegicus	78-84
29805476-8	2018	Sal suppressed inflammatory reactions in serum and liver tissues, and activated the PI3K/Akt signaling pathway to inhibit apoptosis and autophagy in vivo and in vitro, which could be reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	thymoma viral proto-oncogene 1	Mus musculus	89-92
29447944-8	2018	Furthermore, both LY294002, an inhibitor for phosphoinositide-3-kinase (PI3K), and short hairpin RNAs for LXRbeta knockdown, abrogated GW3965-induced Akt phosphorylation, and therefore abolished GW3965-mediated proliferation-promoting of NPCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	thymoma viral proto-oncogene 1	Mus musculus	150-153
29627441-11	2018	The results showed that the pharmacological inhibitor of PI3K/AKT (LY294002) or p38 (SB 203580), but not ERK1/2 (U0126), abrogated AFN-induced Nrf2 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Homo sapiens	62-65
28741371-10	2018	In a further investigation, the DXM-induced protective effect on ALI and rescue effect on downregulation of claudin-5 were both blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	claudin 5	Rattus norvegicus	108-117
29427163-6	2018	The role of NF-kappaB, MAPKs, and Akt signaling pathways was confirmed by using specific inhibitors (BAY 11-7082, U0126, SB202190, SP600125, and LY294002) mediated suppression of TNF-alpha and COX-2 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	nuclear factor kappa B subunit 1	Homo sapiens	12-21
29427163-6	2018	The role of NF-kappaB, MAPKs, and Akt signaling pathways was confirmed by using specific inhibitors (BAY 11-7082, U0126, SB202190, SP600125, and LY294002) mediated suppression of TNF-alpha and COX-2 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	tumor necrosis factor	Homo sapiens	179-188
29427163-6	2018	The role of NF-kappaB, MAPKs, and Akt signaling pathways was confirmed by using specific inhibitors (BAY 11-7082, U0126, SB202190, SP600125, and LY294002) mediated suppression of TNF-alpha and COX-2 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	prostaglandin-endoperoxide synthase 2	Homo sapiens	193-198
29772532-4	2018	By addition of LY294002 or KU-0063794, formation of networking tubular structures from HUVECs in the AP or PP cell conditioned medium was significantly inhibited; whereas, expression level of VEGF-B mRNA in the AP or PP cells was decreased by the former, and increased by the latter significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	vascular endothelial growth factor B	Homo sapiens	192-198
29627441-11	2018	The results showed that the pharmacological inhibitor of PI3K/AKT (LY294002) or p38 (SB 203580), but not ERK1/2 (U0126), abrogated AFN-induced Nrf2 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
29658565-9	2018	In addition, it was confirmed that EPI serves a protective effect against myocardial ischemia via the phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, which was reversed by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	257-265	phosphatase and tensin homolog	Mus musculus	134-138
29568936-10	2018	In addition, in the A375/ISL1 cells treated with the LY294002 inhibitor for 24 and 48 h, the level of Akt was also found to increase compared to the control A375/GFP cells (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	ISL LIM homeobox 1	Homo sapiens	25-29
29568936-10	2018	In addition, in the A375/ISL1 cells treated with the LY294002 inhibitor for 24 and 48 h, the level of Akt was also found to increase compared to the control A375/GFP cells (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	102-105
29524295-9	2018	MICAL1 positively regulated CDK4 and cyclin D expression, but not CDK2, CDK6, cyclin A and cyclin E. In addition, more expression of CDK4 and cyclin D by MICAL1 overexpression was blocked by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	microtubule associated monooxygenase, calponin and LIM domain containing 1	Homo sapiens	0-6
29524295-9	2018	MICAL1 positively regulated CDK4 and cyclin D expression, but not CDK2, CDK6, cyclin A and cyclin E. In addition, more expression of CDK4 and cyclin D by MICAL1 overexpression was blocked by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	cyclin dependent kinase 4	Homo sapiens	28-32
29524295-9	2018	MICAL1 positively regulated CDK4 and cyclin D expression, but not CDK2, CDK6, cyclin A and cyclin E. In addition, more expression of CDK4 and cyclin D by MICAL1 overexpression was blocked by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	cyclin dependent kinase 4	Homo sapiens	133-137
29524295-9	2018	MICAL1 positively regulated CDK4 and cyclin D expression, but not CDK2, CDK6, cyclin A and cyclin E. In addition, more expression of CDK4 and cyclin D by MICAL1 overexpression was blocked by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	microtubule associated monooxygenase, calponin and LIM domain containing 1	Homo sapiens	154-160
29524295-10	2018	LY294002 treatment also attenuated the increase in the p-ERK level in MICAL1-overexpressed breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 1	Homo sapiens	57-60
29524295-10	2018	LY294002 treatment also attenuated the increase in the p-ERK level in MICAL1-overexpressed breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	microtubule associated monooxygenase, calponin and LIM domain containing 1	Homo sapiens	70-76
29970718-0	2018	Baicalein and Ly294002 induces liver cancer cells apoptosis via regulating phosphatidyl inositol 3-kinase/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	106-109
29970718-9	2018	Baicalein and LY294002 significantly suppressed PI3K/Akt signaling pathway-related molecule activity at both mRNA and protein levels (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	53-56
29858824-11	2018	LY294002, an inhibitor of PI3K/Akt signaling pathway, could reverse the events caused by MALAT1 knockdown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	31-34
29658572-14	2018	Ly294002 (10 microM), a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT signaling inhibitor, partially reversed the rotenone-induced alleviation of endotoxin tolerance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	78-81
29696512-7	2018	Expression of PI3K-Akt-mTOR/JNK (24 h after HI or OGD/R) proteins was detected by Western blotting after stimulation with HI, NGR1, LY294002 (PI3K inhibitor), 740Y-P (PI3K agonist), or ICI 182780(estrogen receptors inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
29696512-7	2018	Expression of PI3K-Akt-mTOR/JNK (24 h after HI or OGD/R) proteins was detected by Western blotting after stimulation with HI, NGR1, LY294002 (PI3K inhibitor), 740Y-P (PI3K agonist), or ICI 182780(estrogen receptors inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	mechanistic target of rapamycin kinase	Rattus norvegicus	23-27
29696512-7	2018	Expression of PI3K-Akt-mTOR/JNK (24 h after HI or OGD/R) proteins was detected by Western blotting after stimulation with HI, NGR1, LY294002 (PI3K inhibitor), 740Y-P (PI3K agonist), or ICI 182780(estrogen receptors inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	mitogen-activated protein kinase 8	Rattus norvegicus	28-31
29928327-9	2018	In L428 cells overexpressing TNFR2, the beta-catenin blocker, DKK1, or the AKT inhibitor, LY294002, abrogated the increase in proliferation induced by TNFR2 and increased cell inhibition rate upon treatment with ADM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	TNF receptor superfamily member 1B	Homo sapiens	29-34
29928327-9	2018	In L428 cells overexpressing TNFR2, the beta-catenin blocker, DKK1, or the AKT inhibitor, LY294002, abrogated the increase in proliferation induced by TNFR2 and increased cell inhibition rate upon treatment with ADM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 1	Homo sapiens	75-78
29620222-7	2018	Inhibition of PI3K/AKT by LY294002 downregulated IL-13-induced YY1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	19-22
29928327-9	2018	In L428 cells overexpressing TNFR2, the beta-catenin blocker, DKK1, or the AKT inhibitor, LY294002, abrogated the increase in proliferation induced by TNFR2 and increased cell inhibition rate upon treatment with ADM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	TNF receptor superfamily member 1B	Homo sapiens	151-156
29928334-8	2018	The use of LY294002, a PI3K inhibitor, was able to suppress the activation of Akt and extracellular signal-regulated kinase 1/2, attenuated the migratory and invasive capacities of resistant cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	AKT serine/threonine kinase 1	Homo sapiens	78-81
29620222-7	2018	Inhibition of PI3K/AKT by LY294002 downregulated IL-13-induced YY1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	interleukin 13	Homo sapiens	49-54
29620222-7	2018	Inhibition of PI3K/AKT by LY294002 downregulated IL-13-induced YY1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	YY1 transcription factor	Homo sapiens	63-66
29928334-8	2018	The use of LY294002, a PI3K inhibitor, was able to suppress the activation of Akt and extracellular signal-regulated kinase 1/2, attenuated the migratory and invasive capacities of resistant cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	mitogen-activated protein kinase 3	Homo sapiens	86-127
29669385-6	2018	Treatment with VPC23019, an antagonist against S1P receptor 1 and 3, or LY294002, a PI3K inhibitor, partially reversed these protective properties arising from the overexpression of apoM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	apolipoprotein M	Mus musculus	182-186
29559323-13	2018	Moreover, the expression of Cleaved caspase3 was partially increased and the p-Akt, Nrf2 and HO-1 was partially reduced by a PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Rattus norvegicus	79-82
29559323-13	2018	Moreover, the expression of Cleaved caspase3 was partially increased and the p-Akt, Nrf2 and HO-1 was partially reduced by a PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	NFE2 like bZIP transcription factor 2	Rattus norvegicus	84-88
29555592-10	2018	Conversely, the antioxidant effects of RosA could be blocked by Akt inhibitors LY294002, GSK-3beta inhibitor LiCl, Nrf2 shRNA, or Fyn shRNA in Abeta-challenged PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Rattus norvegicus	64-67
29559323-13	2018	Moreover, the expression of Cleaved caspase3 was partially increased and the p-Akt, Nrf2 and HO-1 was partially reduced by a PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	heme oxygenase 1	Rattus norvegicus	93-97
29572181-4	2018	A phosphoinositide 3-kinase (PI3K) inhibitor LY294002 was used to inhibit the activity of endogenous Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	101-104
29572181-8	2018	LY294002 treatment reduced the phosphorylation levels of Akt1 and 4E-BP1, and the protein levels of type I collagen and alphaSMA in pBOO bladder.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	57-72
29698390-12	2018	The downregulation of miR-145 in serum-induced contact inhibition disruption was related to the activation PI3-kinase/Akt pathway, which was blocked by the PI3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	microRNA 145	Rattus norvegicus	22-29
29698390-12	2018	The downregulation of miR-145 in serum-induced contact inhibition disruption was related to the activation PI3-kinase/Akt pathway, which was blocked by the PI3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
29673487-6	2018	All of the SC79-induced hepatoprotective and DISC-interruptive effects were confirmed to have been reversed by the Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	thymoma viral proto-oncogene 1	Mus musculus	115-118
29450644-0	2018	PI3K/Akt inhibitor LY294002 potentiates homoharringtonine antimyeloma activity in myeloma cells adhered to stromal cells and in SCID mouse xenograft.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	thymoma viral proto-oncogene 1	Mus musculus	5-8
29450644-3	2018	This study aimed to investigate whether PI3K/Akt inhibitor LY294002 could potentiate the antimyeloma activity of HHT against MM cells adhered to BM stromal cells and in vivo xenograft models.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	thymoma viral proto-oncogene 1	Mus musculus	45-48
29450644-9	2018	LY294002 induced apoptosis in MM cells and potentiated the antimyeloma effects of HHT by inhibiting the PI3K/Akt signal pathway which was abnormally activated during adhesion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	109-112
29550144-10	2018	Moreover, we demonstrated that PI3K inhibitor LY294002 could reverse saracatinib resistance in saracatinib-resistant cells, which deserved further preclinical and clinical evaluation of dual inhibition of Src and PI3K in breast cancer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	205-208
29524521-7	2018	The expression levels of CLDN1 and 3 were decreased by LY-294002, a phosphoinositide 3-kinase (PI3K) inhibitor, and BAY 11-7082, an NF-kappaB inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-64	claudin 1	Homo sapiens	25-30
29374601-9	2018	The expressions of p-PI3K, p-AKT2, and PKM2 were increased when stimulated by epidermal growth factor (EGF); however, these expressions were blocked when inhibited the PI3K by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	thymoma viral proto-oncogene 2	Mus musculus	29-33
29496475-6	2018	After the secondary stimulation with Tris-HCl, the Bax expression level in LY294002-pretreatment crayfish was significantly higher than that of crayfish pretreated with Tris-HCl on the third or sixth day, but the Toll and lectin mRNA expression decreased significantly on the third, sixth and tenth day.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	BCL2 associated X, apoptosis regulator	Homo sapiens	51-54
29496475-7	2018	The Bax mRNA expression levels in LY294002-WSSV group were significantly higher than those in Tris-HCl-WSSV group on the third and tenth day.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	BCL2 associated X, apoptosis regulator	Homo sapiens	4-7
29486164-15	2018	Additionally, LY294002, an inhibitor of Akt, suppressed the neurite-promoting effects of the A3 receptor agonist in RGCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Rattus norvegicus	40-43
29496475-8	2018	The Bax inhibitor-1 mRNA expression levels in LY294002-WSSV group were significantly lower than those in Tris-HCl-WSSV crayfish on the third day.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	BCL2 associated X, apoptosis regulator	Homo sapiens	4-7
29374601-9	2018	The expressions of p-PI3K, p-AKT2, and PKM2 were increased when stimulated by epidermal growth factor (EGF); however, these expressions were blocked when inhibited the PI3K by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	pyruvate kinase, muscle	Mus musculus	39-43
29382567-7	2018	Pretreatment of neurons with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 prevented the FGF-23-mediated T-type channel response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	fibroblast growth factor 23	Mus musculus	103-109
29330129-7	2018	Enhanced ICa,L and Cav1.2alpha1C expression by E2 was suppressed by inhibitors of phosphoinositide-3-kinase (Pi3K) (30 muM LY294002; P &lt;.05) and Akt (5 muM MK2206) but not of mitogen-activated protein kinase (5 muM U0126) or protein kinase A (1 muM KT5720).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	82-107
29330129-7	2018	Enhanced ICa,L and Cav1.2alpha1C expression by E2 was suppressed by inhibitors of phosphoinositide-3-kinase (Pi3K) (30 muM LY294002; P &lt;.05) and Akt (5 muM MK2206) but not of mitogen-activated protein kinase (5 muM U0126) or protein kinase A (1 muM KT5720).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	latexin	Homo sapiens	119-122
29512729-14	2018	Furthermore, the levels of p-Akt and p-NF-kappaB caused by SOD could be offset by treatment with curcumin and LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-119	AKT serine/threonine kinase 1	Homo sapiens	29-32
29626279-9	2018	This effect could be reversed by Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
29366902-9	2018	The blockage of PI-3K/Akt or p38 kinase with SB203580 and LY294002 accelerated PEP-1-GRX-1-induced dedifferentiation, but did not have any effect on PEP-GRX-1-induced ER stress.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	glutaredoxin-1	Oryctolagus cuniculus	85-90
29512729-14	2018	Furthermore, the levels of p-Akt and p-NF-kappaB caused by SOD could be offset by treatment with curcumin and LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-119	nuclear factor kappa B subunit 1	Homo sapiens	39-48
29393377-8	2018	These effects of BCL6B were empowered by treatment with the specific phosphoinositide 3 kinase (PI3K)/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	BCL6B transcription repressor	Homo sapiens	17-22
29512729-14	2018	Furthermore, the levels of p-Akt and p-NF-kappaB caused by SOD could be offset by treatment with curcumin and LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-119	superoxide dismutase 1	Homo sapiens	59-62
29393377-8	2018	These effects of BCL6B were empowered by treatment with the specific phosphoinositide 3 kinase (PI3K)/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	102-105
29687528-7	2018	Meanwhile, LY294002, an inhibitor of PI3K/Akt, abolished the protective effect of nobiletin against H2 O2 -induced decreased cell viability and increased caspase-3/7 activity in ARPE-19 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	caspase 3	Homo sapiens	154-163
29393377-9	2018	Furthermore, overexpression of BCL6B resulted in upregulation of E-cadherin and downregulation of cyclin D1 and matrix metalloproteinase-9, which were strongly enhanced by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	BCL6B transcription repressor	Homo sapiens	31-36
29393377-9	2018	Furthermore, overexpression of BCL6B resulted in upregulation of E-cadherin and downregulation of cyclin D1 and matrix metalloproteinase-9, which were strongly enhanced by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	cyclin D1	Homo sapiens	98-138
29687528-7	2018	Meanwhile, LY294002, an inhibitor of PI3K/Akt, abolished the protective effect of nobiletin against H2 O2 -induced decreased cell viability and increased caspase-3/7 activity in ARPE-19 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	AKT serine/threonine kinase 1	Homo sapiens	42-45
29488612-7	2018	In addition, LY294002, an protein kinase B (Akt) inhibitor, greatly suppressed the expression level of phospho (p)-Akt, matrix metalloproteinase (MMP)-9 and p-mammalian target of rapamycin (mTOR), suggesting that the activation of the Akt/mTOR/MMP-9 signaling pathway may participate in regulating cell migration in PCa.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	44-47
29605032-11	2018	At the cellular level, PHLPP-1 siRNA attenuated cellular injury, and this was associated with increased p-Akt and nuclear Nrf2 protein, whereas the decrement of Akt phosphorylation induced by LY294002 augmented cellular injury and decreased nuclear Nrf2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	192-200	thymoma viral proto-oncogene 1	Mus musculus	161-164
29488612-7	2018	In addition, LY294002, an protein kinase B (Akt) inhibitor, greatly suppressed the expression level of phospho (p)-Akt, matrix metalloproteinase (MMP)-9 and p-mammalian target of rapamycin (mTOR), suggesting that the activation of the Akt/mTOR/MMP-9 signaling pathway may participate in regulating cell migration in PCa.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	115-118
29488612-7	2018	In addition, LY294002, an protein kinase B (Akt) inhibitor, greatly suppressed the expression level of phospho (p)-Akt, matrix metalloproteinase (MMP)-9 and p-mammalian target of rapamycin (mTOR), suggesting that the activation of the Akt/mTOR/MMP-9 signaling pathway may participate in regulating cell migration in PCa.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	matrix metallopeptidase 9	Homo sapiens	120-152
29488612-7	2018	In addition, LY294002, an protein kinase B (Akt) inhibitor, greatly suppressed the expression level of phospho (p)-Akt, matrix metalloproteinase (MMP)-9 and p-mammalian target of rapamycin (mTOR), suggesting that the activation of the Akt/mTOR/MMP-9 signaling pathway may participate in regulating cell migration in PCa.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	mechanistic target of rapamycin kinase	Homo sapiens	157-188
29488612-7	2018	In addition, LY294002, an protein kinase B (Akt) inhibitor, greatly suppressed the expression level of phospho (p)-Akt, matrix metalloproteinase (MMP)-9 and p-mammalian target of rapamycin (mTOR), suggesting that the activation of the Akt/mTOR/MMP-9 signaling pathway may participate in regulating cell migration in PCa.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	mechanistic target of rapamycin kinase	Homo sapiens	190-194
29488612-7	2018	In addition, LY294002, an protein kinase B (Akt) inhibitor, greatly suppressed the expression level of phospho (p)-Akt, matrix metalloproteinase (MMP)-9 and p-mammalian target of rapamycin (mTOR), suggesting that the activation of the Akt/mTOR/MMP-9 signaling pathway may participate in regulating cell migration in PCa.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	115-118
29488612-7	2018	In addition, LY294002, an protein kinase B (Akt) inhibitor, greatly suppressed the expression level of phospho (p)-Akt, matrix metalloproteinase (MMP)-9 and p-mammalian target of rapamycin (mTOR), suggesting that the activation of the Akt/mTOR/MMP-9 signaling pathway may participate in regulating cell migration in PCa.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	mechanistic target of rapamycin kinase	Homo sapiens	239-243
29488612-7	2018	In addition, LY294002, an protein kinase B (Akt) inhibitor, greatly suppressed the expression level of phospho (p)-Akt, matrix metalloproteinase (MMP)-9 and p-mammalian target of rapamycin (mTOR), suggesting that the activation of the Akt/mTOR/MMP-9 signaling pathway may participate in regulating cell migration in PCa.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	matrix metallopeptidase 9	Homo sapiens	244-249
29908644-11	2018	LY294002, a specific inhibitor of PI3K, blocked CdCl2-evoked Akt phosphorylation in JEG-3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	61-64
29731895-6	2018	In addition, LY294002 (the PI3K inhibitor) and/or PD98059 (the ERK1/2 inhibitor) blocked the enhancement of BM-MSC transplantation on the expression of Seladin-1 and nestin in the hippocampus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	24-dehydrocholesterol reductase	Homo sapiens	152-161
29908644-12	2018	Concomitantly, LY294002 inhibited CdCl2-induced IL-8 in JEG-3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
29729706-10	2018	TGFbeta1 significantly induced the PI3K/Akt pathway and the PI3K/Akt pathway inhibitor LY294002 significantly downregulated basal as well as TGFbeta1 induced alternative splicing of EDA+Fn in human podocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	transforming growth factor beta 1	Homo sapiens	0-8
29729706-10	2018	TGFbeta1 significantly induced the PI3K/Akt pathway and the PI3K/Akt pathway inhibitor LY294002 significantly downregulated basal as well as TGFbeta1 induced alternative splicing of EDA+Fn in human podocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	65-68
29729706-10	2018	TGFbeta1 significantly induced the PI3K/Akt pathway and the PI3K/Akt pathway inhibitor LY294002 significantly downregulated basal as well as TGFbeta1 induced alternative splicing of EDA+Fn in human podocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	transforming growth factor beta 1	Homo sapiens	141-149
29666854-6	2018	Furthermore, GMPH inhibited nuclear transcription factor kappa-B (NF-kappaB) activation by suppressing the nuclear translocation of NF-kappaB p65, which was markedly reversed by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-64
29463070-6	2018	CSE increased the transcription of IL-17RA/RC and surface membrane expression of IL-17R, which was suppressed by an inhibitor of the phosphoinositide 3-kinase (PI3K)/Akt pathway (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	interleukin 17 receptor A	Homo sapiens	35-42
29463070-6	2018	CSE increased the transcription of IL-17RA/RC and surface membrane expression of IL-17R, which was suppressed by an inhibitor of the phosphoinositide 3-kinase (PI3K)/Akt pathway (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	interleukin 17 receptor A	Homo sapiens	35-41
29463070-6	2018	CSE increased the transcription of IL-17RA/RC and surface membrane expression of IL-17R, which was suppressed by an inhibitor of the phosphoinositide 3-kinase (PI3K)/Akt pathway (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	133-158
29463070-6	2018	CSE increased the transcription of IL-17RA/RC and surface membrane expression of IL-17R, which was suppressed by an inhibitor of the phosphoinositide 3-kinase (PI3K)/Akt pathway (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	AKT serine/threonine kinase 1	Homo sapiens	166-169
29588342-8	2018	The AKT inhibitor LY294002 also suppressed TGFbeta2-induced up-regulation of nuclear Snail and reduced phosphorylation of GSK3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	4-7
29588342-8	2018	The AKT inhibitor LY294002 also suppressed TGFbeta2-induced up-regulation of nuclear Snail and reduced phosphorylation of GSK3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	transforming growth factor beta 2	Homo sapiens	43-51
29588342-8	2018	The AKT inhibitor LY294002 also suppressed TGFbeta2-induced up-regulation of nuclear Snail and reduced phosphorylation of GSK3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	snail family transcriptional repressor 1	Homo sapiens	85-90
29588342-8	2018	The AKT inhibitor LY294002 also suppressed TGFbeta2-induced up-regulation of nuclear Snail and reduced phosphorylation of GSK3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	glycogen synthase kinase 3 beta	Homo sapiens	122-130
29700291-9	2018	Furthermore, BOC-2, Rp-cAMP, and LY294002 blocked the increased alveolar fluid clearance in response to protectin DX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	CD59 molecule	Rattus norvegicus	104-113
29666854-6	2018	Furthermore, GMPH inhibited nuclear transcription factor kappa-B (NF-kappaB) activation by suppressing the nuclear translocation of NF-kappaB p65, which was markedly reversed by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
29666854-6	2018	Furthermore, GMPH inhibited nuclear transcription factor kappa-B (NF-kappaB) activation by suppressing the nuclear translocation of NF-kappaB p65, which was markedly reversed by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	132-141
29805303-5	2018	Elongator-driven migration and invasion and the expression of MMP-2 and MMP-9 were reduced in HCC cells treated with AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	matrix metallopeptidase 2	Homo sapiens	62-67
29731993-4	2018	Gene silencing of AKT1 or treatment of LY294002 (PI3 kinase inhibitor) increased E-cadherin, whereas decreased phospho-GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	cadherin 1	Homo sapiens	81-91
29731993-4	2018	Gene silencing of AKT1 or treatment of LY294002 (PI3 kinase inhibitor) increased E-cadherin, whereas decreased phospho-GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	glycogen synthase kinase 3 beta	Homo sapiens	119-128
29524402-7	2018	Akt and mTOR/P70S6K phosphorylation was inhibited by LY 294002 but not by PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-62	AKT serine/threonine kinase 1	Homo sapiens	0-3
29524402-7	2018	Akt and mTOR/P70S6K phosphorylation was inhibited by LY 294002 but not by PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-62	mechanistic target of rapamycin kinase	Homo sapiens	8-12
29524402-7	2018	Akt and mTOR/P70S6K phosphorylation was inhibited by LY 294002 but not by PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-62	ribosomal protein S6 kinase B1	Homo sapiens	13-19
29805303-5	2018	Elongator-driven migration and invasion and the expression of MMP-2 and MMP-9 were reduced in HCC cells treated with AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	matrix metallopeptidase 9	Homo sapiens	72-77
29805303-5	2018	Elongator-driven migration and invasion and the expression of MMP-2 and MMP-9 were reduced in HCC cells treated with AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	117-120
29634420-6	2018	In vitro, high glucose increased HMGA1 expression and promoted proliferation of VSMCs, which could be blunted by Wortmannin and LY294002, inhibitors of PI3K/Akt pathway, and specificity protein 1 (SP1) siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	high mobility group AT-hook 1	Rattus norvegicus	33-38
29687856-10	2018	LY294002 significantly decreased p-AKT, Bcl-2, and VEGF expressions, and alleviated the cell apoptosis protective and angiogenesis effect induced by G-CSF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	35-38
29319206-8	2018	Furthermore, pretreatment of cells with LY294002 (an AKT inhibitor) and U0126 (ERK1/2 inhibitor) revealed that ERK1/2 activity is also involved in BP-mediated signal transduction in HTR8/SVneo cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	mitogen-activated protein kinase 3	Homo sapiens	111-117
29501569-9	2018	Further, LY294002 treatment had no effect on decreased expression of Bach2 induced by BCR-ABL, but significantly eliminated BCR-ABL-induced phosphorylation of Bach2 and restored reduced nuclear translocation of Bach2 induced by BCR-ABL in B cells from SLE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	124-131
29319206-8	2018	Furthermore, pretreatment of cells with LY294002 (an AKT inhibitor) and U0126 (ERK1/2 inhibitor) revealed that ERK1/2 activity is also involved in BP-mediated signal transduction in HTR8/SVneo cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	53-56
29470962-5	2018	Such events were also duplicated with a cell-permeable C2-ceramide and Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Homo sapiens	71-74
29545835-5	2018	Western blotting demonstrated that the expression of p-FOXO1 and B-cell lymphoma 2 (Bcl2) were significantly reduced, whereas the expression of Bcl-2-associated X protein was significantly increased following treatment with LY294002 and/or UO126 (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	forkhead box O1	Homo sapiens	55-60
29545835-5	2018	Western blotting demonstrated that the expression of p-FOXO1 and B-cell lymphoma 2 (Bcl2) were significantly reduced, whereas the expression of Bcl-2-associated X protein was significantly increased following treatment with LY294002 and/or UO126 (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	BCL2 apoptosis regulator	Homo sapiens	65-82
29545835-5	2018	Western blotting demonstrated that the expression of p-FOXO1 and B-cell lymphoma 2 (Bcl2) were significantly reduced, whereas the expression of Bcl-2-associated X protein was significantly increased following treatment with LY294002 and/or UO126 (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	BCL2 apoptosis regulator	Homo sapiens	84-88
29545835-5	2018	Western blotting demonstrated that the expression of p-FOXO1 and B-cell lymphoma 2 (Bcl2) were significantly reduced, whereas the expression of Bcl-2-associated X protein was significantly increased following treatment with LY294002 and/or UO126 (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	BCL2 apoptosis regulator	Homo sapiens	144-149
29556265-7	2018	Furthermore, the aforementioned changes were mediated by the AOPP-phosphorylated phosphoinositide 3-kinase3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway; this was verified by treatment with LY294002, a PI3K inhibitor, which reversed the AOPP-induced changes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	227-235	AKT serine/threonine kinase 1	Homo sapiens	140-143
29556265-7	2018	Furthermore, the aforementioned changes were mediated by the AOPP-phosphorylated phosphoinositide 3-kinase3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway; this was verified by treatment with LY294002, a PI3K inhibitor, which reversed the AOPP-induced changes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	227-235	mechanistic target of rapamycin kinase	Homo sapiens	145-174
29556265-7	2018	Furthermore, the aforementioned changes were mediated by the AOPP-phosphorylated phosphoinositide 3-kinase3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway; this was verified by treatment with LY294002, a PI3K inhibitor, which reversed the AOPP-induced changes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	227-235	mechanistic target of rapamycin kinase	Homo sapiens	176-180
29501569-9	2018	Further, LY294002 treatment had no effect on decreased expression of Bach2 induced by BCR-ABL, but significantly eliminated BCR-ABL-induced phosphorylation of Bach2 and restored reduced nuclear translocation of Bach2 induced by BCR-ABL in B cells from SLE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	BTB domain and CNC homolog 2	Homo sapiens	159-164
29501569-9	2018	Further, LY294002 treatment had no effect on decreased expression of Bach2 induced by BCR-ABL, but significantly eliminated BCR-ABL-induced phosphorylation of Bach2 and restored reduced nuclear translocation of Bach2 induced by BCR-ABL in B cells from SLE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	BTB domain and CNC homolog 2	Homo sapiens	159-164
29687856-10	2018	LY294002 significantly decreased p-AKT, Bcl-2, and VEGF expressions, and alleviated the cell apoptosis protective and angiogenesis effect induced by G-CSF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2, apoptosis regulator	Rattus norvegicus	40-45
29501569-9	2018	Further, LY294002 treatment had no effect on decreased expression of Bach2 induced by BCR-ABL, but significantly eliminated BCR-ABL-induced phosphorylation of Bach2 and restored reduced nuclear translocation of Bach2 induced by BCR-ABL in B cells from SLE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	124-131
29687856-10	2018	LY294002 significantly decreased p-AKT, Bcl-2, and VEGF expressions, and alleviated the cell apoptosis protective and angiogenesis effect induced by G-CSF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	vascular endothelial growth factor A	Rattus norvegicus	51-55
29687856-10	2018	LY294002 significantly decreased p-AKT, Bcl-2, and VEGF expressions, and alleviated the cell apoptosis protective and angiogenesis effect induced by G-CSF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	colony stimulating factor 3	Rattus norvegicus	149-154
31938335-7	2018	LY294002, an inhibitor of the PI3K/AKT pathway, was also given to one of the groups.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	35-38
29393372-5	2018	After adding the phosphatidylinositol 3-kinase (PI3K)/AKT signaling inhibitor LY294002 or wortmannin to the LIF differentiation group, LIF-induced changes in the protein expression of TUJ1 and MAP2 were reversed, but this effect could not be prevented by rapamycin, a mechanistic target of rapamycin signaling inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	AKT serine/threonine kinase 1	Homo sapiens	54-57
29393372-5	2018	After adding the phosphatidylinositol 3-kinase (PI3K)/AKT signaling inhibitor LY294002 or wortmannin to the LIF differentiation group, LIF-induced changes in the protein expression of TUJ1 and MAP2 were reversed, but this effect could not be prevented by rapamycin, a mechanistic target of rapamycin signaling inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	LIF interleukin 6 family cytokine	Homo sapiens	108-111
29393372-5	2018	After adding the phosphatidylinositol 3-kinase (PI3K)/AKT signaling inhibitor LY294002 or wortmannin to the LIF differentiation group, LIF-induced changes in the protein expression of TUJ1 and MAP2 were reversed, but this effect could not be prevented by rapamycin, a mechanistic target of rapamycin signaling inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	LIF interleukin 6 family cytokine	Homo sapiens	135-138
29393372-5	2018	After adding the phosphatidylinositol 3-kinase (PI3K)/AKT signaling inhibitor LY294002 or wortmannin to the LIF differentiation group, LIF-induced changes in the protein expression of TUJ1 and MAP2 were reversed, but this effect could not be prevented by rapamycin, a mechanistic target of rapamycin signaling inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	microtubule associated protein 2	Homo sapiens	193-197
29330470-6	2018	Subsequently, Akt-dependent NF-kappaB activation is required for Bcl-2 upregulation, but not Bax downregulation, in response to beta-Ecd, which was validated by the use of LY294002 and Bay11-7082.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	AKT serine/threonine kinase 1	Homo sapiens	14-17
29377505-10	2018	In cultured cardiomyocytes, high glucose increased mTOR phosphorylation, which was inhibited by the PI3 kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	mechanistic target of rapamycin kinase	Homo sapiens	51-55
29472382-12	2018	The D2R-mediated increase in leptin expression was prevented by the phosphoinositide 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	leptin	Mus musculus	29-35
29330470-6	2018	Subsequently, Akt-dependent NF-kappaB activation is required for Bcl-2 upregulation, but not Bax downregulation, in response to beta-Ecd, which was validated by the use of LY294002 and Bay11-7082.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	nuclear factor kappa B subunit 1	Homo sapiens	28-37
29552203-13	2018	Furthermore, overexpression of S100A6 in HeLa cells activated the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway, and treatment with the PI3K inhibitor LY294002 partially repressed S100A6-enhanced proliferation and migration of cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	S100 calcium binding protein A6	Homo sapiens	31-37
28497199-9	2018	Moreover, AA-induced HO-1 expression was mediated through phosphorylation of Src, Pyk2, platelet-derived growth factor, PI3K/Akt, and ERK1/2 which were inhibited by the pharmacological inhibitors including PP1, PF431396, AG1296, LY294002, and U0126 or by transfection with respective siRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	heme oxygenase 1	Rattus norvegicus	21-25
29435803-10	2018	The addition of LY294002, a PI3K inhibitor, could suppress phosphorylation of Akt and CREB and activate GSK-3beta, resulting in abolishment of neuroprotective effects of rifampicin on cells exposed to rotenone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	78-81
29435803-10	2018	The addition of LY294002, a PI3K inhibitor, could suppress phosphorylation of Akt and CREB and activate GSK-3beta, resulting in abolishment of neuroprotective effects of rifampicin on cells exposed to rotenone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	cAMP responsive element binding protein 1	Homo sapiens	86-90
29435803-10	2018	The addition of LY294002, a PI3K inhibitor, could suppress phosphorylation of Akt and CREB and activate GSK-3beta, resulting in abolishment of neuroprotective effects of rifampicin on cells exposed to rotenone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	glycogen synthase kinase 3 beta	Homo sapiens	104-113
29541204-5	2018	The present study revealed that LY294002 inhibited GC cell proliferation, induced early apoptosis and significantly decreased lactate dehydrogenase activity and lactate production, in part through inhibiting PKM2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	pyruvate kinase M1/2	Homo sapiens	208-212
29541204-6	2018	In summary, LY294002 exhibits anticancer effects on GC, partly via the downregulation of PKM2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	pyruvate kinase M1/2	Homo sapiens	89-93
29556314-7	2018	Research into the molecular mechanism was performed and the results identified that protein kinase B (AKT) and extracellular signal-related kinase signal pathways were both stimulated by VASH1, but only AKT inhibitor LY294002 was identified to efficiently counteract increases in P-gp expression that had been induced by silencing of VASH1 in U-2OS cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	AKT serine/threonine kinase 1	Homo sapiens	203-206
29556314-7	2018	Research into the molecular mechanism was performed and the results identified that protein kinase B (AKT) and extracellular signal-related kinase signal pathways were both stimulated by VASH1, but only AKT inhibitor LY294002 was identified to efficiently counteract increases in P-gp expression that had been induced by silencing of VASH1 in U-2OS cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	ATP binding cassette subfamily B member 1	Homo sapiens	280-284
29556314-8	2018	ADR resistance promoted by silencing VASH1 in U-2OS cells was also counteracted by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	vasohibin 1	Homo sapiens	37-42
29541204-0	2018	LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	pyruvate kinase M1/2	Homo sapiens	79-97
29552230-9	2018	Furthermore, treatment with the AKT inhibitor LY294002 or the ERK inhibitor U0126 inhibited the upregulation of VEGF-A induced by FAP expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	32-35
29552230-9	2018	Furthermore, treatment with the AKT inhibitor LY294002 or the ERK inhibitor U0126 inhibited the upregulation of VEGF-A induced by FAP expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	vascular endothelial growth factor A	Homo sapiens	112-118
29552230-9	2018	Furthermore, treatment with the AKT inhibitor LY294002 or the ERK inhibitor U0126 inhibited the upregulation of VEGF-A induced by FAP expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	fibroblast activation protein alpha	Homo sapiens	130-133
29552203-13	2018	Furthermore, overexpression of S100A6 in HeLa cells activated the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway, and treatment with the PI3K inhibitor LY294002 partially repressed S100A6-enhanced proliferation and migration of cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	66-91
29552203-13	2018	Furthermore, overexpression of S100A6 in HeLa cells activated the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway, and treatment with the PI3K inhibitor LY294002 partially repressed S100A6-enhanced proliferation and migration of cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	AKT serine/threonine kinase 1	Homo sapiens	117-120
29552203-13	2018	Furthermore, overexpression of S100A6 in HeLa cells activated the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway, and treatment with the PI3K inhibitor LY294002 partially repressed S100A6-enhanced proliferation and migration of cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	S100 calcium binding protein A6	Homo sapiens	208-214
29463067-9	2018	Pretreatment of cells with the PI3K inhibitor LY294002, PKA inhibitor H89, and siRNAs GLP-1R, beta-catenin abrogated the liraglutide-induced activation of cAMP, AKT, beta-catenin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	cathelicidin antimicrobial peptide	Mus musculus	155-159
29662626-5	2018	LY294002 and MK2206, two inhibitors of the PI3K/Akt pathway, mimicked the effect of the inhibition of EGFR/ErbB2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	48-51
29662626-5	2018	LY294002 and MK2206, two inhibitors of the PI3K/Akt pathway, mimicked the effect of the inhibition of EGFR/ErbB2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	epidermal growth factor receptor	Homo sapiens	102-106
29662626-5	2018	LY294002 and MK2206, two inhibitors of the PI3K/Akt pathway, mimicked the effect of the inhibition of EGFR/ErbB2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	107-112
29643035-8	2018	The rats treated with LY294002 showed decreased 24-h urinary protein and TRPC6 expression without significant changes in fasting blood glucose, serum creatinine, urea nitrogen, or expressions of nephrin and VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	73-78
29643035-8	2018	The rats treated with LY294002 showed decreased 24-h urinary protein and TRPC6 expression without significant changes in fasting blood glucose, serum creatinine, urea nitrogen, or expressions of nephrin and VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	vascular endothelial growth factor A	Rattus norvegicus	207-211
30090596-10	2018	Furthermore, both LY294002 (an inhibitor of PI3K) and MK-2206 (an inhibitor of Akt) could significantly decrease the elevated TNF-alpha gene expressions, suggesting that the PI3K/Akt pathway was involved in the regulation of TNF-alpha expressions induced by 1-AP and 3-AF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	tumor necrosis factor	Homo sapiens	126-135
29588573-5	2018	Further study disclosed that Vit enhanced the phosphorylation of PI3K and Akt which was downregulated by MPP+ in SH-SY5Y cells, the effect of which could be blocked by PI3K inhibitor LY294002 and activated by PI3K activator IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	AKT serine/threonine kinase 1	Homo sapiens	74-77
30090596-10	2018	Furthermore, both LY294002 (an inhibitor of PI3K) and MK-2206 (an inhibitor of Akt) could significantly decrease the elevated TNF-alpha gene expressions, suggesting that the PI3K/Akt pathway was involved in the regulation of TNF-alpha expressions induced by 1-AP and 3-AF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	179-182
30090596-10	2018	Furthermore, both LY294002 (an inhibitor of PI3K) and MK-2206 (an inhibitor of Akt) could significantly decrease the elevated TNF-alpha gene expressions, suggesting that the PI3K/Akt pathway was involved in the regulation of TNF-alpha expressions induced by 1-AP and 3-AF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	tumor necrosis factor	Homo sapiens	225-234
29538428-11	2018	In contrast, using the PI3K inhibitor LY294002 to block Akt activation effectively inhibited the protective effects of tilianin against MIRI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Rattus norvegicus	56-59
25588050-8	2018	PI3K/AKT inhibitor (LY294002), while not ERK inhibitor (PD98059), significantly abolished G-1 induced up regulation of MMP-9 in both AHCN and OS-RC-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	5-8
29475002-8	2018	LY294002, a specific pI3k inhibitor, partially reversed the decreased HMGB1 expression, increased p-Akt expression induced by celastrol, and abolished the anti-apoptotic, anti-inflammatory and anti-oxidative effects of celastrol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	high mobility group box 1	Rattus norvegicus	70-75
29475002-8	2018	LY294002, a specific pI3k inhibitor, partially reversed the decreased HMGB1 expression, increased p-Akt expression induced by celastrol, and abolished the anti-apoptotic, anti-inflammatory and anti-oxidative effects of celastrol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	100-103
25588050-8	2018	PI3K/AKT inhibitor (LY294002), while not ERK inhibitor (PD98059), significantly abolished G-1 induced up regulation of MMP-9 in both AHCN and OS-RC-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	matrix metallopeptidase 9	Homo sapiens	119-124
28675791-10	2018	Inhibition of Akt with LY294002 abolished all of the protective effects of Olp.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
29507613-6	2018	Results: Inhibition of autophagy by LY294002 was associated with a fourfold up-regulation of adiponectin expression and a decrease of RNF157 protein and pro-inflammatory markers-MCP-1 and TNFalpha predominantly in visceral adipocytes of obese WOKW rats compared to LEW.1W rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	93-104
29507613-6	2018	Results: Inhibition of autophagy by LY294002 was associated with a fourfold up-regulation of adiponectin expression and a decrease of RNF157 protein and pro-inflammatory markers-MCP-1 and TNFalpha predominantly in visceral adipocytes of obese WOKW rats compared to LEW.1W rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	ring finger protein 157	Rattus norvegicus	134-140
29507613-6	2018	Results: Inhibition of autophagy by LY294002 was associated with a fourfold up-regulation of adiponectin expression and a decrease of RNF157 protein and pro-inflammatory markers-MCP-1 and TNFalpha predominantly in visceral adipocytes of obese WOKW rats compared to LEW.1W rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	mast cell protease 1-like 1	Rattus norvegicus	178-183
29507613-6	2018	Results: Inhibition of autophagy by LY294002 was associated with a fourfold up-regulation of adiponectin expression and a decrease of RNF157 protein and pro-inflammatory markers-MCP-1 and TNFalpha predominantly in visceral adipocytes of obese WOKW rats compared to LEW.1W rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	tumor necrosis factor	Rattus norvegicus	188-196
29422438-4	2018	The results indicated that LH increased androstenedione secretion and relative abundance of CYP17A1 and BCL2 mRNA in the TCs, whereas LH in combination with LY294002, a PI3K/AKT inhibitor, decreased LH-induced function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	cytochrome P450 family 17 subfamily A member 1A	Capra hircus	92-99
29052277-8	2018	Moreover, LY294002, the AKT inhibitor, significantly inhibited EGF-induced upregulation of ZEB1 and ZEB2 as well as EMT and migration stimulated by EGF in gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	zinc finger E-box binding homeobox 1	Homo sapiens	91-95
28699113-6	2018	However, treatment with the estrogen receptor (ER) antagonist ICI182, 780 or phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 suppressed the effects of naringenin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	77-106
29052277-8	2018	Moreover, LY294002, the AKT inhibitor, significantly inhibited EGF-induced upregulation of ZEB1 and ZEB2 as well as EMT and migration stimulated by EGF in gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	24-27
29052277-8	2018	Moreover, LY294002, the AKT inhibitor, significantly inhibited EGF-induced upregulation of ZEB1 and ZEB2 as well as EMT and migration stimulated by EGF in gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	zinc finger E-box binding homeobox 2	Homo sapiens	100-104
29217185-8	2018	Moreover, LY294002, the specific phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) inhibitor, significantly alleviated the effects of sAPS on autophagy and PCV2 replication.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	82-85
29218606-6	2018	Then we found that PI3K inhibitor LY294002 reduced L-selectin- and PSGL-1-induced mRNA upregulation of IL-18 in Jurkat cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	selectin L	Homo sapiens	51-61
29218606-6	2018	Then we found that PI3K inhibitor LY294002 reduced L-selectin- and PSGL-1-induced mRNA upregulation of IL-18 in Jurkat cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	selectin P ligand	Homo sapiens	67-73
29218606-6	2018	Then we found that PI3K inhibitor LY294002 reduced L-selectin- and PSGL-1-induced mRNA upregulation of IL-18 in Jurkat cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	interleukin 18	Homo sapiens	103-108
28969943-7	2018	The Jak 1/2 inhibitor ruxolitinib, the mTOR inhibitor rapamycin and the PI3 kinase inhibitor LY294002 all prevented the potentiation of cell death by IL-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	interleukin 13	Homo sapiens	150-155
29459421-5	2018	IGF-1-induced activation of Akt and the protective effect of IGF-1 on MPP+-induced apoptosis were abolished by chemical inhibition of PDK1 (GSK2334470) or PI3K (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	insulin like growth factor 1	Homo sapiens	0-5
29459421-5	2018	IGF-1-induced activation of Akt and the protective effect of IGF-1 on MPP+-induced apoptosis were abolished by chemical inhibition of PDK1 (GSK2334470) or PI3K (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	AKT serine/threonine kinase 1	Homo sapiens	28-31
29459421-5	2018	IGF-1-induced activation of Akt and the protective effect of IGF-1 on MPP+-induced apoptosis were abolished by chemical inhibition of PDK1 (GSK2334470) or PI3K (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	insulin like growth factor 1	Homo sapiens	61-66
29459421-10	2018	Furthermore, the protective effects of IGF-1 on oxidative stress and mitochondrial dysfunction were attenuated when cells were preincubated with GSK2334470 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	insulin like growth factor 1	Homo sapiens	39-44
28238097-5	2018	Inhibition of the PI3K/Akt pathway by the PI3K-specific inhibitor, LY294002 or inhibition of Akt by Akt-specific inhibitors Akt inhibitor VIII or SN-38, or downregulation Akt with siRNA specific for Akt blocked the effect of IGF-1 on hRPE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Homo sapiens	23-26
29472543-8	2018	PI3K-Akt pathway and H3K27me3 form a feedback loop in rd1 retina, thus PI3K inhibitor LY294002 reduces phosphorylation of Ezh2 at serine 21 and enhances H3K27me3 deposition, and inhibiting H3K27me3 by DZNep can activate PI3K-Akt pathway by de-repressing gene expression of PI3K subunits Pik3r1 and Pik3r3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	thymoma viral proto-oncogene 1	Mus musculus	5-8
28871449-7	2018	Mechanistically, we found that overexpressed ARHGEF39 significantly increased the phosphorylation level of Akt (p-Akt), and its effect on cell proliferation was attenuated by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	Rho guanine nucleotide exchange factor 39	Homo sapiens	45-53
28871449-7	2018	Mechanistically, we found that overexpressed ARHGEF39 significantly increased the phosphorylation level of Akt (p-Akt), and its effect on cell proliferation was attenuated by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	AKT serine/threonine kinase 1	Homo sapiens	107-110
28871449-7	2018	Mechanistically, we found that overexpressed ARHGEF39 significantly increased the phosphorylation level of Akt (p-Akt), and its effect on cell proliferation was attenuated by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	AKT serine/threonine kinase 1	Homo sapiens	112-117
29328421-11	2018	It is worth noting that the inhibition of mTOR by rapamycin or of PI3K/Akt by LY294002 augmented curcumin-induced apoptosis and autophagy, leading to significant inhibition of cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	AKT serine/threonine kinase 1	Homo sapiens	71-74
29357017-12	2018	However, treatment with LY294002 (PI3K inhibitor) reversed the BBR-induced increases in BDNF and p-Akt proteins and decreased cleaved caspase-3 protein expression in focal cerebral ischemic rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	brain-derived neurotrophic factor	Rattus norvegicus	88-92
29581767-7	2018	Moreover, upon inhibition of PI3K/AKT pathway by PI3K-inhibitor LY294002 or AKT-inhibitor mk2206, the radiosensitivity of ARID1A-deficient pancreatic cancer cells is improved in vitro via increased apoptosis and weakened DDR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Homo sapiens	34-37
29472543-8	2018	PI3K-Akt pathway and H3K27me3 form a feedback loop in rd1 retina, thus PI3K inhibitor LY294002 reduces phosphorylation of Ezh2 at serine 21 and enhances H3K27me3 deposition, and inhibiting H3K27me3 by DZNep can activate PI3K-Akt pathway by de-repressing gene expression of PI3K subunits Pik3r1 and Pik3r3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	54-57
29472543-8	2018	PI3K-Akt pathway and H3K27me3 form a feedback loop in rd1 retina, thus PI3K inhibitor LY294002 reduces phosphorylation of Ezh2 at serine 21 and enhances H3K27me3 deposition, and inhibiting H3K27me3 by DZNep can activate PI3K-Akt pathway by de-repressing gene expression of PI3K subunits Pik3r1 and Pik3r3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	122-126
29472543-8	2018	PI3K-Akt pathway and H3K27me3 form a feedback loop in rd1 retina, thus PI3K inhibitor LY294002 reduces phosphorylation of Ezh2 at serine 21 and enhances H3K27me3 deposition, and inhibiting H3K27me3 by DZNep can activate PI3K-Akt pathway by de-repressing gene expression of PI3K subunits Pik3r1 and Pik3r3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	thymoma viral proto-oncogene 1	Mus musculus	225-228
29472543-8	2018	PI3K-Akt pathway and H3K27me3 form a feedback loop in rd1 retina, thus PI3K inhibitor LY294002 reduces phosphorylation of Ezh2 at serine 21 and enhances H3K27me3 deposition, and inhibiting H3K27me3 by DZNep can activate PI3K-Akt pathway by de-repressing gene expression of PI3K subunits Pik3r1 and Pik3r3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	287-293
29472543-8	2018	PI3K-Akt pathway and H3K27me3 form a feedback loop in rd1 retina, thus PI3K inhibitor LY294002 reduces phosphorylation of Ezh2 at serine 21 and enhances H3K27me3 deposition, and inhibiting H3K27me3 by DZNep can activate PI3K-Akt pathway by de-repressing gene expression of PI3K subunits Pik3r1 and Pik3r3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	phosphoinositide-3-kinase regulatory subunit 3	Mus musculus	298-304
29439547-6	2018	However, these factors were down-regulated by DP2 antagonist (TM30089) and AKT inhibitor (LY294002) as well as DP2 knockdown in hDPCs decreased AR expression and AKT signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 1	Homo sapiens	75-78
29467020-9	2018	The activities of the phosphoinositol 3-kinase (PI3K)/AKT signaling pathway and DNA methyltransferases (DNMTs) were enhanced, and their respective inhibitors LY294002 and 5-azacytidine (5-AZA) blunted c-kit expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	thymoma viral proto-oncogene 1	Mus musculus	54-57
29352987-4	2018	We found that scratching on EC monolayer triggered XBP1splicing, which was attenuated by the presence of SU5416and LY294002, suggesting that VEGF signalling pathways may be involved.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	X-box binding protein 1	Homo sapiens	51-55
29352987-4	2018	We found that scratching on EC monolayer triggered XBP1splicing, which was attenuated by the presence of SU5416and LY294002, suggesting that VEGF signalling pathways may be involved.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	vascular endothelial growth factor A	Homo sapiens	141-145
29459829-5	2018	Pretreatment with an inhibitor (U0126) of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) and an inhibitor (LY294002) of phosphoinositide 3-kinase (PI3K) failed to significantly inhibit PTTH-stimulated JNK phosphorylation, indicating that ERK and PI3K were not related to JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	phosphatidylinositol 3-kinase 60	Bombyx mori	170-195
29459829-5	2018	Pretreatment with an inhibitor (U0126) of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) and an inhibitor (LY294002) of phosphoinositide 3-kinase (PI3K) failed to significantly inhibit PTTH-stimulated JNK phosphorylation, indicating that ERK and PI3K were not related to JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	prothoracicotropic hormone	Bombyx mori	235-239
29459829-5	2018	Pretreatment with an inhibitor (U0126) of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) and an inhibitor (LY294002) of phosphoinositide 3-kinase (PI3K) failed to significantly inhibit PTTH-stimulated JNK phosphorylation, indicating that ERK and PI3K were not related to JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	c-Jun NH2-terminal kinase	Bombyx mori	251-254
29459829-5	2018	Pretreatment with an inhibitor (U0126) of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) and an inhibitor (LY294002) of phosphoinositide 3-kinase (PI3K) failed to significantly inhibit PTTH-stimulated JNK phosphorylation, indicating that ERK and PI3K were not related to JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	extracellular regulated MAP kinase	Bombyx mori	288-291
29459829-5	2018	Pretreatment with an inhibitor (U0126) of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) and an inhibitor (LY294002) of phosphoinositide 3-kinase (PI3K) failed to significantly inhibit PTTH-stimulated JNK phosphorylation, indicating that ERK and PI3K were not related to JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	c-Jun NH2-terminal kinase	Bombyx mori	321-324
29497316-9	2018	Pretreatment with an AKT inhibitor LY294002 markedly attenuated IL-33-induced cell migration and invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	21-24
29497316-9	2018	Pretreatment with an AKT inhibitor LY294002 markedly attenuated IL-33-induced cell migration and invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	interleukin 33	Homo sapiens	64-69
29444190-7	2018	These protective effects could be blocked by both a miR-21 inhibitor and the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	AKT serine/threonine kinase 1	Homo sapiens	82-85
29444704-13	2018	RESULTS: LY294002 administration decreased serum levels of E2 and AMH, while the levels of FSH, LH and AZPAb in serum were increased compared with mice in the hPMSC transplantation group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	59-69
29444704-16	2018	Also, LY294002 administration significantly decreased proliferation and increased cell apoptosis in GCs, and for immune factors the ratios of Th17/Tc17 and Th17/Treg cells were significantly increased, as well as the serum levels of IL-17.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	interleukin 17A	Mus musculus	233-238
29556340-6	2018	In contrast, blocking PI3K and AKT using LY294002 and MK-2206, respectively, decreased PTRF expression, showing that PTRF is regulated in the EGFR/PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	31-34
29556340-6	2018	In contrast, blocking PI3K and AKT using LY294002 and MK-2206, respectively, decreased PTRF expression, showing that PTRF is regulated in the EGFR/PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	caveolae associated protein 1	Homo sapiens	87-91
29556340-6	2018	In contrast, blocking PI3K and AKT using LY294002 and MK-2206, respectively, decreased PTRF expression, showing that PTRF is regulated in the EGFR/PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	caveolae associated protein 1	Homo sapiens	117-121
29556340-6	2018	In contrast, blocking PI3K and AKT using LY294002 and MK-2206, respectively, decreased PTRF expression, showing that PTRF is regulated in the EGFR/PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	epidermal growth factor receptor	Homo sapiens	142-146
29467759-6	2018	However, MG suspended the activation of PPARalpha expression and was thus blocked by pretreatment with LY294002 and compound c (specific inhibitors of AKT and AMPK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	peroxisome proliferator activated receptor alpha	Mus musculus	40-49
29467759-6	2018	However, MG suspended the activation of PPARalpha expression and was thus blocked by pretreatment with LY294002 and compound c (specific inhibitors of AKT and AMPK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	thymoma viral proto-oncogene 1	Mus musculus	151-154
29278851-11	2018	LY294002 and Wortmannin, phosphotidylinsitol-3-kinase (PI3K) inhibitors, blocked FBXO11 induced EMT, proliferation, migration and invasion of SGC-7901 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	F-box protein 11	Homo sapiens	81-87
28940008-5	2018	Moreover, LY294002, an inhibitor of the PI3K/Akt pathway enhanced the Dex-induced apoptosis of osteoblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	thymoma viral proto-oncogene 1	Mus musculus	45-48
33052635-10	2018	Western blot analysis showed that PDCD4 overexpression or PI3K inhibition by LY294002 significantly reduced the expression of phospho-PI3K, phospho-Akt, phospho-mammalian target of rapamycin and phospho-p70s6k, but not their total protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	programmed cell death 4	Homo sapiens	34-39
33052635-10	2018	Western blot analysis showed that PDCD4 overexpression or PI3K inhibition by LY294002 significantly reduced the expression of phospho-PI3K, phospho-Akt, phospho-mammalian target of rapamycin and phospho-p70s6k, but not their total protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	148-151
33052635-10	2018	Western blot analysis showed that PDCD4 overexpression or PI3K inhibition by LY294002 significantly reduced the expression of phospho-PI3K, phospho-Akt, phospho-mammalian target of rapamycin and phospho-p70s6k, but not their total protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	mechanistic target of rapamycin kinase	Homo sapiens	161-190
33052635-10	2018	Western blot analysis showed that PDCD4 overexpression or PI3K inhibition by LY294002 significantly reduced the expression of phospho-PI3K, phospho-Akt, phospho-mammalian target of rapamycin and phospho-p70s6k, but not their total protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	ribosomal protein S6 kinase B1	Homo sapiens	203-209
29161771-12	2018	Pro-neurogenic effects of TBN were attributed to its activation of the AKT/cAMP responsive element-binding protein through increasing brain-derived neurotrophic factor (BDNF) expression, as shown by the abolition of the effects of TBN by a specific inhibitor of BDNF receptor ANA-12 and by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	309-317	AKT serine/threonine kinase 1	Rattus norvegicus	71-74
29207091-9	2018	Molecular mechanism analysis demonstrated that p-ERK and p-Akt in SW1116 and HT29 cells were affected by alterations in FAP-alpha expression, and treatment with a p-ERK inhibitor (U0126) and p-Akt inhibitor (LY294002) ameliorated VEGF-A upregulation induced by FAP-alpha overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	47-52
29234153-9	2018	More importantly, blocking these pathways with their antagonists LY294002 or U0126 reversed the effects of netrin-1 overexpression on cell invasion, migration, EMT, and VM formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	netrin 1	Homo sapiens	107-115
29461611-5	2018	Finally, Western blot was used to detect the expressions of Akt and extracellular regulated protein kinases 1/2 (Erk1/2) signal pathway-associated proteins after nucleus pulposus cells were treated with LY294002, the phosphatidylinositol 3-kinase (PI3K) inhibitor, and PD98059, the extracellular regulated protein kinases (MEK) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	AKT serine/threonine kinase 1	Homo sapiens	60-63
29461611-5	2018	Finally, Western blot was used to detect the expressions of Akt and extracellular regulated protein kinases 1/2 (Erk1/2) signal pathway-associated proteins after nucleus pulposus cells were treated with LY294002, the phosphatidylinositol 3-kinase (PI3K) inhibitor, and PD98059, the extracellular regulated protein kinases (MEK) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	mitogen-activated protein kinase 3	Homo sapiens	68-111
29461611-5	2018	Finally, Western blot was used to detect the expressions of Akt and extracellular regulated protein kinases 1/2 (Erk1/2) signal pathway-associated proteins after nucleus pulposus cells were treated with LY294002, the phosphatidylinositol 3-kinase (PI3K) inhibitor, and PD98059, the extracellular regulated protein kinases (MEK) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	mitogen-activated protein kinase 3	Homo sapiens	113-119
29257253-9	2018	However, it was revealed that PI3K inhibitor, LY294002, could attenuate the effects of TSLP on in vitro angiogenesis of OGD-treated HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	thymic stromal lymphopoietin	Homo sapiens	87-91
29129468-6	2018	More importantly, these beneficial effects of Rac1 inhibition were abolished by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	Rac family small GTPase 1	Rattus norvegicus	46-50
28771872-6	2018	Furthermore, pretreatment with an autophagy inhibitor 3MA or LY294002 attenuated the suppressive effect of atorvastatin on LPS-induced IL-1beta and TNFalpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	interleukin 1 beta	Mus musculus	135-143
28771872-6	2018	Furthermore, pretreatment with an autophagy inhibitor 3MA or LY294002 attenuated the suppressive effect of atorvastatin on LPS-induced IL-1beta and TNFalpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	tumor necrosis factor	Mus musculus	148-156
29207130-10	2018	Furthermore, treatment or co-treatment with LY294002 (phosphoinositide-3-kinase/Akt inhibitor) or Pifithrin-alpha (p53 inhibitor) with CME resulted in CME-induced G1 arrest which occurred through the p53-independent signaling pathway in hepatocellular carcinoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	tumor protein p53	Homo sapiens	200-203
29207091-9	2018	Molecular mechanism analysis demonstrated that p-ERK and p-Akt in SW1116 and HT29 cells were affected by alterations in FAP-alpha expression, and treatment with a p-ERK inhibitor (U0126) and p-Akt inhibitor (LY294002) ameliorated VEGF-A upregulation induced by FAP-alpha overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	AKT serine/threonine kinase 1	Homo sapiens	59-62
29207091-9	2018	Molecular mechanism analysis demonstrated that p-ERK and p-Akt in SW1116 and HT29 cells were affected by alterations in FAP-alpha expression, and treatment with a p-ERK inhibitor (U0126) and p-Akt inhibitor (LY294002) ameliorated VEGF-A upregulation induced by FAP-alpha overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	mitogen-activated protein kinase 1	Homo sapiens	49-52
29207091-9	2018	Molecular mechanism analysis demonstrated that p-ERK and p-Akt in SW1116 and HT29 cells were affected by alterations in FAP-alpha expression, and treatment with a p-ERK inhibitor (U0126) and p-Akt inhibitor (LY294002) ameliorated VEGF-A upregulation induced by FAP-alpha overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	AKT serine/threonine kinase 1	Homo sapiens	193-196
29207091-9	2018	Molecular mechanism analysis demonstrated that p-ERK and p-Akt in SW1116 and HT29 cells were affected by alterations in FAP-alpha expression, and treatment with a p-ERK inhibitor (U0126) and p-Akt inhibitor (LY294002) ameliorated VEGF-A upregulation induced by FAP-alpha overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	vascular endothelial growth factor A	Homo sapiens	230-236
29207091-9	2018	Molecular mechanism analysis demonstrated that p-ERK and p-Akt in SW1116 and HT29 cells were affected by alterations in FAP-alpha expression, and treatment with a p-ERK inhibitor (U0126) and p-Akt inhibitor (LY294002) ameliorated VEGF-A upregulation induced by FAP-alpha overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	fibroblast activation protein alpha	Homo sapiens	261-270
29789792-9	2018	LY294002 significantly attenuated RIPostC-increased levels of Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	62-65
29207170-7	2018	The phosphatidylinositol 3-kinase inhibitor LY294002 and the agonist IGF-1 were employed to suppress or induce the phosphorylation of Akt to determine whether BMI-1 induces radioresistance in ESCC cells via activation of the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	134-137
29207170-14	2018	Additionally, the inhibitory effect of the downregulation of p-Akt by LY294002 on tumour cell viability was identical to that of BMI-1 knockdown, while the kinase agonist IGF-1 reversed the effects of BMI-1 knockdown on cell viability and radiosensitivity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Homo sapiens	63-66
29496179-20	2018	TFCC also activated phosphorylation of AKT, whereas the addition of LY294002, which is the pharmacologic inhibitor of PI3K, blocked the TFCC-induced Nrf2/HO-1 activation and cytoprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-153
29496179-20	2018	TFCC also activated phosphorylation of AKT, whereas the addition of LY294002, which is the pharmacologic inhibitor of PI3K, blocked the TFCC-induced Nrf2/HO-1 activation and cytoprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	heme oxygenase 1	Rattus norvegicus	154-158
29233229-6	2018	BAX and BCL2 expression levels in the cumulus cells were only affected by FSH, and the BAX levels decreased after treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	BCL2 associated X, apoptosis regulator	Bos taurus	0-3
29233229-6	2018	BAX and BCL2 expression levels in the cumulus cells were only affected by FSH, and the BAX levels decreased after treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	BCL2 associated X, apoptosis regulator	Bos taurus	87-90
29386059-7	2018	The phosphatidylinositol 3-kinase inhibitor LY294002 was used to inhibit Akt to verify miR-150 increase NK/T cell lymphoma cell radiorsensitivity through suppress the PI3K/AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	73-76
29386059-7	2018	The phosphatidylinositol 3-kinase inhibitor LY294002 was used to inhibit Akt to verify miR-150 increase NK/T cell lymphoma cell radiorsensitivity through suppress the PI3K/AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	microRNA 150	Homo sapiens	87-94
29386059-7	2018	The phosphatidylinositol 3-kinase inhibitor LY294002 was used to inhibit Akt to verify miR-150 increase NK/T cell lymphoma cell radiorsensitivity through suppress the PI3K/AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	172-175
29386059-7	2018	The phosphatidylinositol 3-kinase inhibitor LY294002 was used to inhibit Akt to verify miR-150 increase NK/T cell lymphoma cell radiorsensitivity through suppress the PI3K/AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	mechanistic target of rapamycin kinase	Homo sapiens	176-180
29189472-4	2018	We found that both NAD and NADH significantly increased the intracellular ATP levels of BV2 microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2, and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	sirtuin 2	Mus musculus	128-133
28470144-13	2018	The application of a PI3K kinase inhibitor, LY294002, on HSC-3 DKK3 cells significantly decreased tumor cell proliferation, migration, and invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	DnaJ heat shock protein family (Hsp40) member B7	Homo sapiens	57-62
28470144-13	2018	The application of a PI3K kinase inhibitor, LY294002, on HSC-3 DKK3 cells significantly decreased tumor cell proliferation, migration, and invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	63-67
29288664-10	2018	Blockade of PI3K activity by inhibitors (LY294002) dramatically abolished its anti-apoptotic effect and lowered both visual function and Akt phosphorylation levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Rattus norvegicus	137-140
29263137-8	2018	Using the signaling pathway inhibitor LY294002, we found that Bcl-2 expression and eNOS phosphorylation after Ninj1 blockade were regulated via PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	BCL2 apoptosis regulator	Homo sapiens	62-67
29263137-8	2018	Using the signaling pathway inhibitor LY294002, we found that Bcl-2 expression and eNOS phosphorylation after Ninj1 blockade were regulated via PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	ninjurin 1	Homo sapiens	110-115
29263137-8	2018	Using the signaling pathway inhibitor LY294002, we found that Bcl-2 expression and eNOS phosphorylation after Ninj1 blockade were regulated via PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	149-152
29391778-10	2018	According to the mechanism, promotion of ALP and Runx2 interdicted by LY294002 and siGPR30 reduced the activation of PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	alkaline phosphatase, placental	Homo sapiens	41-44
29423015-7	2018	The PI3K/AKT inhibitor LY294002 mirrored the effects of loss of CD133; whereas, the PI3K/AKT activator epidermal growth factor reproduced the effects of CD133 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	prominin 1	Homo sapiens	64-69
29507694-8	2018	Further supporting these results, we observed that pretreatment with the phosphatidylinositol 3-kinase inhibitor LY294002 abolished NGR1-mediated neuroprotective effects against oxidative stress and NLRP3 inflammasome activation in HG-treated HT22 hippocampal neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	reticulon 4 receptor	Mus musculus	132-136
29507694-8	2018	Further supporting these results, we observed that pretreatment with the phosphatidylinositol 3-kinase inhibitor LY294002 abolished NGR1-mediated neuroprotective effects against oxidative stress and NLRP3 inflammasome activation in HG-treated HT22 hippocampal neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	NLR family, pyrin domain containing 3	Mus musculus	199-204
29229447-6	2018	Inhibition of PI3K/Akt signaling by LY294002 suppressed the expression of hnRNP A1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	19-22
29229447-6	2018	Inhibition of PI3K/Akt signaling by LY294002 suppressed the expression of hnRNP A1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	74-82
29248464-10	2018	Pre-treatment of cells with selective inhibitors of AKT (LY294002) and ERK1/2 (U0126) revealed that the AKT and ERK1/2 signaling pathways regulated by DA displayed cross-talk in HTR8/SVneo cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	52-55
29248464-10	2018	Pre-treatment of cells with selective inhibitors of AKT (LY294002) and ERK1/2 (U0126) revealed that the AKT and ERK1/2 signaling pathways regulated by DA displayed cross-talk in HTR8/SVneo cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	104-107
29248464-10	2018	Pre-treatment of cells with selective inhibitors of AKT (LY294002) and ERK1/2 (U0126) revealed that the AKT and ERK1/2 signaling pathways regulated by DA displayed cross-talk in HTR8/SVneo cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	mitogen-activated protein kinase 3	Homo sapiens	112-118
29391778-10	2018	According to the mechanism, promotion of ALP and Runx2 interdicted by LY294002 and siGPR30 reduced the activation of PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	RUNX family transcription factor 2	Homo sapiens	49-54
29169284-5	2018	VEGFC stimulated the proliferation and DNA synthesis of GC-1 cells and enhanced the phosphorylation of PI3K-AKT and MAPK, whereas LY294002 (an inhibitor for AKT) and CI-1040 (an inhibitor for MAPK) blocked the effect of VEGFC on GC-1 cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	thymoma viral proto-oncogene 1	Mus musculus	157-160
29198702-11	2018	Furthermore, the protective effects of hydrogen were abrogated by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Homo sapiens	71-74
29198711-6	2018	The blocking of this pathway by its inhibitor LY294002 impaired the proliferative effect of CCN2 on chondrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	cellular communication network factor 2	Homo sapiens	92-96
29136768-8	2018	Injection of LY294002 notably inhibited the phosphorylation of Akt, and the expression of total Akt and Nrf2 and HO-1 after SCI in LXA4-treated rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	63-66
29136768-8	2018	Injection of LY294002 notably inhibited the phosphorylation of Akt, and the expression of total Akt and Nrf2 and HO-1 after SCI in LXA4-treated rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
29136768-8	2018	Injection of LY294002 notably inhibited the phosphorylation of Akt, and the expression of total Akt and Nrf2 and HO-1 after SCI in LXA4-treated rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	104-108
29136768-8	2018	Injection of LY294002 notably inhibited the phosphorylation of Akt, and the expression of total Akt and Nrf2 and HO-1 after SCI in LXA4-treated rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	heme oxygenase 1	Rattus norvegicus	113-117
29924135-6	2018	Histological analysis showed that exenatide significantly reversed HF-induced lipid accumulation and inflammatory changes accompanied by decreased FTO mRNA and protein expression, which were abrogated by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	alpha-ketoglutarate-dependent dioxygenase FTO	Oryctolagus cuniculus	147-150
29329563-9	2018	Furthermore, an AKT inhibitor (LY294002), NF-kappaB inhibitor (BAY11-7082), and STAT3 inhibitor (Stattic) significantly down-regulated O-PMs-induced ICAM-1 expression as well as the adhesion of U937 cells to epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	16-19
29329563-9	2018	Furthermore, an AKT inhibitor (LY294002), NF-kappaB inhibitor (BAY11-7082), and STAT3 inhibitor (Stattic) significantly down-regulated O-PMs-induced ICAM-1 expression as well as the adhesion of U937 cells to epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	intercellular adhesion molecule 1	Homo sapiens	149-155
29298720-8	2018	The involvement of MEK/ERK and PI3K/AKT signaling in CCAT2 regulation was investigated by pathway inhibitors PD98059 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	colon cancer associated transcript 2	Homo sapiens	53-58
29137974-9	2018	In addition, the increasing levels of Nestin, MAP2 and pAKT in the MMP2 group were declined by pretreatment with the phosphoinositide 3-kinase (PI3K)/AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	nestin	Homo sapiens	38-44
29137974-9	2018	In addition, the increasing levels of Nestin, MAP2 and pAKT in the MMP2 group were declined by pretreatment with the phosphoinositide 3-kinase (PI3K)/AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	microtubule associated protein 2	Homo sapiens	46-50
29137974-9	2018	In addition, the increasing levels of Nestin, MAP2 and pAKT in the MMP2 group were declined by pretreatment with the phosphoinositide 3-kinase (PI3K)/AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	matrix metallopeptidase 2	Homo sapiens	67-71
29137974-9	2018	In addition, the increasing levels of Nestin, MAP2 and pAKT in the MMP2 group were declined by pretreatment with the phosphoinositide 3-kinase (PI3K)/AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	117-142
29137974-9	2018	In addition, the increasing levels of Nestin, MAP2 and pAKT in the MMP2 group were declined by pretreatment with the phosphoinositide 3-kinase (PI3K)/AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	AKT serine/threonine kinase 1	Homo sapiens	56-59
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	272-280	mitogen-activated protein kinase 8	Mus musculus	101-107
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	sphingosine-1-phosphate receptor 1	Mus musculus	168-171
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	272-280	sphingosine-1-phosphate receptor 1	Mus musculus	168-171
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	sphingosine-1-phosphate receptor 2	Mus musculus	172-177
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	sphingosine-1-phosphate receptor 1	Mus musculus	172-175
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	sphingosine-1-phosphate receptor 2	Mus musculus	256-261
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	272-280	mitogen-activated protein kinase 8	Mus musculus	101-104
29669317-13	2018	Moreover, induction of CCL4 was blocked by PI3 Kinase inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	C-C motif chemokine ligand 4	Homo sapiens	23-27
30355923-12	2018	Erinacine or LY294002 led to a decrease in mitochondrial membrane potential, increase in intracellular mitochondrial Ca2+, and the release of cyt-C in mitochondria.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cytochrome c, somatic	Homo sapiens	142-147
28914370-7	2018	LY-294002 was used for the inhibition of PI3K-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	AKT serine/threonine kinase 1	Homo sapiens	46-49
29133128-6	2018	Blockage of AKT signalling pathway by a specific AKT inhibitor LY294002 impaired BCA3 mediated phenotypes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	AKT serine/threonine kinase 1	Homo sapiens	12-15
29133128-6	2018	Blockage of AKT signalling pathway by a specific AKT inhibitor LY294002 impaired BCA3 mediated phenotypes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	AKT serine/threonine kinase 1	Homo sapiens	49-52
29133128-6	2018	Blockage of AKT signalling pathway by a specific AKT inhibitor LY294002 impaired BCA3 mediated phenotypes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	A-kinase interacting protein 1	Homo sapiens	81-85
29983082-8	2018	Finally, pre-treatment with LY294002 abrogated attenuation of the H2O2-induced decrease in cell viability and increase in caspase-3/7 activity by Orexin-A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	caspase 3	Homo sapiens	122-131
29208568-7	2018	Furthermore, the promotive effects of ELF3 on cellular proliferation and metastasis could be rescued by Ly294002 (inhibitor of PI3K) and U0126 (inhibitor of MEK1/2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	E74 like ETS transcription factor 3	Homo sapiens	38-42
28881413-8	2018	And the LY294002 could reverse the effect of low SEMA6C expression on primordial follicle activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	Mus musculus	49-55
30175975-13	2018	Pretreated neurons with LY294002, an inhibitor of PI3K, partially blocked berberine-inhibited tau phosphorylation and berberine-activated PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Rattus norvegicus	143-146
29454612-5	2018	Using western blots, we measured the phosphorylation of 4E-BP and S6K proteins, the main targets of TOR, following the in vitro exposure of PGs to brain extract containing PTTH (hereafter referred to as PTTH) and/or the inhibitors of MAPK (U0126), PI3K (LY294002) or TOR (rapamycin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	254-262	prothoracicotropic hormone	Bombyx mori	172-176
30485163-10	2018	The expression of p-Akt protein in the presence of PI3K/Akt signaling pathway inhibitor LY294002 and SCL was not markedly changed indicating that signal transduction was affected by this Chinese herb.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Rattus norvegicus	20-23
28780388-10	2018	p-AKT and p-S6 activation by Mn is almost completely blocked upon addition of NU7441(5muM) or LY294002(7muM), supporting PI3K"s upstream role in the AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	thymoma viral proto-oncogene 1	Mus musculus	2-5
29641644-11	2018	Pre-treatment of endothelial cells with NADPH oxidase (DPI and apocynin) and PI3K/Akt pathway (LY294002) inhibitors reduced ROS production, bacterial intracellular viability, and generation of actin stress fibres in HUVECs infected with S. agalactiae.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	82-85
28766166-8	2018	miR-363 mimic downregulated the levels of p-PI3K/Akt, miR-363 inhibitor upregulated the levels of p-PI3K/Akt, and miR-363 mimic and PI3K/Akt pathway inhibitor LY294002 reversed the positive effect of rhPDGF-BB on the proliferation of hADSCs, which suggested that rhPDGF-BB promoted the proliferation of hADSCs via miR-363/PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	microRNA 363	Homo sapiens	0-7
28766166-8	2018	miR-363 mimic downregulated the levels of p-PI3K/Akt, miR-363 inhibitor upregulated the levels of p-PI3K/Akt, and miR-363 mimic and PI3K/Akt pathway inhibitor LY294002 reversed the positive effect of rhPDGF-BB on the proliferation of hADSCs, which suggested that rhPDGF-BB promoted the proliferation of hADSCs via miR-363/PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	AKT serine/threonine kinase 1	Homo sapiens	49-52
28766166-8	2018	miR-363 mimic downregulated the levels of p-PI3K/Akt, miR-363 inhibitor upregulated the levels of p-PI3K/Akt, and miR-363 mimic and PI3K/Akt pathway inhibitor LY294002 reversed the positive effect of rhPDGF-BB on the proliferation of hADSCs, which suggested that rhPDGF-BB promoted the proliferation of hADSCs via miR-363/PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	microRNA 363	Homo sapiens	54-61
28766166-8	2018	miR-363 mimic downregulated the levels of p-PI3K/Akt, miR-363 inhibitor upregulated the levels of p-PI3K/Akt, and miR-363 mimic and PI3K/Akt pathway inhibitor LY294002 reversed the positive effect of rhPDGF-BB on the proliferation of hADSCs, which suggested that rhPDGF-BB promoted the proliferation of hADSCs via miR-363/PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	microRNA 363	Homo sapiens	54-61
28766166-8	2018	miR-363 mimic downregulated the levels of p-PI3K/Akt, miR-363 inhibitor upregulated the levels of p-PI3K/Akt, and miR-363 mimic and PI3K/Akt pathway inhibitor LY294002 reversed the positive effect of rhPDGF-BB on the proliferation of hADSCs, which suggested that rhPDGF-BB promoted the proliferation of hADSCs via miR-363/PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	microRNA 363	Homo sapiens	54-61
29115508-11	2018	Furthermore, the cellular protective effect of overexpression of DJ-1 enhanced p-Akt/Akt ratio, eNOS activation and NO production, and these trends were partially reversed by a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	Parkinsonism associated deglycase	Homo sapiens	65-69
29115508-11	2018	Furthermore, the cellular protective effect of overexpression of DJ-1 enhanced p-Akt/Akt ratio, eNOS activation and NO production, and these trends were partially reversed by a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	177-223
28736242-8	2018	In addition, blocking Akt/eNOS pathway activation by the specific inhibitor LY294002 (LY, 10 muL, 10 mmol/L) or L-NIO (0.5 mg/kg) partially reversed the protective effects of TRPM7 suppression and its anti-oxidative activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
28736242-8	2018	In addition, blocking Akt/eNOS pathway activation by the specific inhibitor LY294002 (LY, 10 muL, 10 mmol/L) or L-NIO (0.5 mg/kg) partially reversed the protective effects of TRPM7 suppression and its anti-oxidative activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	nitric oxide synthase 3	Rattus norvegicus	26-30
28736242-8	2018	In addition, blocking Akt/eNOS pathway activation by the specific inhibitor LY294002 (LY, 10 muL, 10 mmol/L) or L-NIO (0.5 mg/kg) partially reversed the protective effects of TRPM7 suppression and its anti-oxidative activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	transient receptor potential cation channel, subfamily M, member 7	Rattus norvegicus	175-180
28736242-8	2018	In addition, blocking Akt/eNOS pathway activation by the specific inhibitor LY294002 (LY, 10 muL, 10 mmol/L) or L-NIO (0.5 mg/kg) partially reversed the protective effects of TRPM7 suppression and its anti-oxidative activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-78	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
28736242-8	2018	In addition, blocking Akt/eNOS pathway activation by the specific inhibitor LY294002 (LY, 10 muL, 10 mmol/L) or L-NIO (0.5 mg/kg) partially reversed the protective effects of TRPM7 suppression and its anti-oxidative activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-78	nitric oxide synthase 3	Rattus norvegicus	26-30
28736242-8	2018	In addition, blocking Akt/eNOS pathway activation by the specific inhibitor LY294002 (LY, 10 muL, 10 mmol/L) or L-NIO (0.5 mg/kg) partially reversed the protective effects of TRPM7 suppression and its anti-oxidative activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-78	transient receptor potential cation channel, subfamily M, member 7	Rattus norvegicus	175-180
29577981-9	2018	In addition, pretreatment with AKT inhibitor LY294002 could obviously attenuate PFOS-induced NF-kappaB activation and IL-1beta secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	31-34
29577981-9	2018	In addition, pretreatment with AKT inhibitor LY294002 could obviously attenuate PFOS-induced NF-kappaB activation and IL-1beta secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	nuclear factor kappa B subunit 1	Homo sapiens	93-102
29577981-9	2018	In addition, pretreatment with AKT inhibitor LY294002 could obviously attenuate PFOS-induced NF-kappaB activation and IL-1beta secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	interleukin 1 beta	Homo sapiens	118-126
29175450-6	2018	HCh-3 and LY294002 (alone or in combination) as well as Tiotropium (Spiriva ) or Olodaterol (alone or in combination) all reduced the levels of pPEBP1, pbeta2AR, pERK1/2, ROS, NOX-4, and IL-8 in 16HBE LECSE compared to untreated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	NADPH oxidase 4	Homo sapiens	176-181
29175450-6	2018	HCh-3 and LY294002 (alone or in combination) as well as Tiotropium (Spiriva ) or Olodaterol (alone or in combination) all reduced the levels of pPEBP1, pbeta2AR, pERK1/2, ROS, NOX-4, and IL-8 in 16HBE LECSE compared to untreated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
29115424-5	2018	Additionally, it was observed that following inhibition of PI3K/Akt by LY294002, the levels of p-Akt and p-mTOR were markedly decreased, and the LC3-II/LC3-I ratio and beclin-1 were increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Homo sapiens	64-67
29115424-5	2018	Additionally, it was observed that following inhibition of PI3K/Akt by LY294002, the levels of p-Akt and p-mTOR were markedly decreased, and the LC3-II/LC3-I ratio and beclin-1 were increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Homo sapiens	97-100
29115424-5	2018	Additionally, it was observed that following inhibition of PI3K/Akt by LY294002, the levels of p-Akt and p-mTOR were markedly decreased, and the LC3-II/LC3-I ratio and beclin-1 were increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	mechanistic target of rapamycin kinase	Homo sapiens	107-111
28986282-11	2018	Effects of Ex-4 were reversed by the intervention of GLP-1R siRNA and LY294002 in SAH + Ex-4+GLP-1R siRNA and SAH + Ex-4+LY294002 groups, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	glucagon-like peptide 1 receptor	Rattus norvegicus	93-99
28780388-10	2018	p-AKT and p-S6 activation by Mn is almost completely blocked upon addition of NU7441(5muM) or LY294002(7muM), supporting PI3K"s upstream role in the AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	thymoma viral proto-oncogene 1	Mus musculus	149-152
28780388-10	2018	p-AKT and p-S6 activation by Mn is almost completely blocked upon addition of NU7441(5muM) or LY294002(7muM), supporting PI3K"s upstream role in the AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	mechanistic target of rapamycin kinase	Mus musculus	153-157
29387228-4	2018	NSCLC cells were treated with insulin in the absence or presence of LY294002, an inhibitor of the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	103-106
29375710-10	2018	The phosphoinositide 3-kinase (PI3K) inhibitor, LY294002, significantly inhibited PANC-1 cell proliferation, promoted apoptosis and caused G1/S phase arrest in PANC-1 cells (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-29
29387228-9	2018	However, the effects of insulin on NSCLC cells was inhibited by the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	insulin	Homo sapiens	24-31
29387228-9	2018	However, the effects of insulin on NSCLC cells was inhibited by the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	73-76
29435149-9	2018	The adding of PI3K inhibitor LY294002 played an opposite role to miR-361-5p mimic by inducing autophagy and chemoresistance to docetaxel of gastric cancer cells compared with docetaxel + miR-361-5p mimic group, indicating that miR-361-5p suppressed autophagy-induced chemoresistance via the PI3K/Akt/mTOR pathway in gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	microRNA 361	Homo sapiens	65-72
29282029-9	2017	In addition, DHA enhanced the inhibitory effect of LY294002 on pAkt signaling and expression of p-SREBP-1, m-SREBP-1, and FASN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	sterol regulatory element binding transcription factor 1	Homo sapiens	98-105
29282029-9	2017	In addition, DHA enhanced the inhibitory effect of LY294002 on pAkt signaling and expression of p-SREBP-1, m-SREBP-1, and FASN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	sterol regulatory element binding transcription factor 1	Homo sapiens	109-116
29282029-9	2017	In addition, DHA enhanced the inhibitory effect of LY294002 on pAkt signaling and expression of p-SREBP-1, m-SREBP-1, and FASN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	fatty acid synthase	Homo sapiens	122-126
29295560-4	2017	A cell viability assay revealed that pharmacological suppression of AKT using LY294002 enhanced the anti-cancer effect of fascaplysin in various cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	AKT serine/threonine kinase 1	Homo sapiens	68-71
29953987-6	2018	Knockdown of XPC using siRNA or inactivation of AKT by pharmacological inhibitor PI3K inhibitor (LY294002) enhanced the cytotoxic effects of etoposide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	13-16
29953987-6	2018	Knockdown of XPC using siRNA or inactivation of AKT by pharmacological inhibitor PI3K inhibitor (LY294002) enhanced the cytotoxic effects of etoposide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	48-51
29435149-9	2018	The adding of PI3K inhibitor LY294002 played an opposite role to miR-361-5p mimic by inducing autophagy and chemoresistance to docetaxel of gastric cancer cells compared with docetaxel + miR-361-5p mimic group, indicating that miR-361-5p suppressed autophagy-induced chemoresistance via the PI3K/Akt/mTOR pathway in gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	microRNA 361	Homo sapiens	187-194
29435149-9	2018	The adding of PI3K inhibitor LY294002 played an opposite role to miR-361-5p mimic by inducing autophagy and chemoresistance to docetaxel of gastric cancer cells compared with docetaxel + miR-361-5p mimic group, indicating that miR-361-5p suppressed autophagy-induced chemoresistance via the PI3K/Akt/mTOR pathway in gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	microRNA 361	Homo sapiens	187-194
29435149-9	2018	The adding of PI3K inhibitor LY294002 played an opposite role to miR-361-5p mimic by inducing autophagy and chemoresistance to docetaxel of gastric cancer cells compared with docetaxel + miR-361-5p mimic group, indicating that miR-361-5p suppressed autophagy-induced chemoresistance via the PI3K/Akt/mTOR pathway in gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	296-299
29435149-9	2018	The adding of PI3K inhibitor LY294002 played an opposite role to miR-361-5p mimic by inducing autophagy and chemoresistance to docetaxel of gastric cancer cells compared with docetaxel + miR-361-5p mimic group, indicating that miR-361-5p suppressed autophagy-induced chemoresistance via the PI3K/Akt/mTOR pathway in gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	mechanistic target of rapamycin kinase	Homo sapiens	300-304
29240812-8	2017	Moreover, vaspin increased the Akt phosphorylation protein level which was reversed by PI3K inhibitor ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	serpin family A member 12	Rattus norvegicus	10-16
28302479-10	2017	MiR-126 silencing possessed obvious protective effects on the intestinal barrier function, but these effects could be reversed by JTE-013 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	microRNA 126	Homo sapiens	0-7
29241458-9	2017	IGF1, IGF1R, AKT p-IGF1, p-IGF1R, and p-Akt protein expression was enhanced dose-dependently with metformin, and was also significantly changed by treatment of CP70 cells with 0 mM metformin +10 mM LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	198-206	insulin like growth factor 1	Homo sapiens	0-4
29241458-9	2017	IGF1, IGF1R, AKT p-IGF1, p-IGF1R, and p-Akt protein expression was enhanced dose-dependently with metformin, and was also significantly changed by treatment of CP70 cells with 0 mM metformin +10 mM LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	198-206	AKT serine/threonine kinase 1	Homo sapiens	13-16
29240812-8	2017	Moreover, vaspin increased the Akt phosphorylation protein level which was reversed by PI3K inhibitor ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	AKT serine/threonine kinase 1	Rattus norvegicus	31-34
29311781-10	2017	Furthermore, the beneficial effects of netrin-1 were suppressed by PI3K inhibitors 3-Methyladenine and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	netrin 1	Rattus norvegicus	39-47
28855026-6	2017	Induction of FN expression was dampened by LY294002 or AKT IV in TamR cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	fibronectin 1	Homo sapiens	13-15
29228922-16	2017	Furthermore, the PI3K inhibitor LY294002 could effectively reversed SALL2 siRNA-induced phosphorylation of Akt, migration and invasion of A2780 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	spalt like transcription factor 2	Homo sapiens	68-73
29228922-16	2017	Furthermore, the PI3K inhibitor LY294002 could effectively reversed SALL2 siRNA-induced phosphorylation of Akt, migration and invasion of A2780 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	107-110
29037812-2	2017	Here we report that apoA-IV treatment elicited a rapid activation of the phosphatidylinositol-3-kinase (PI3K) signaling pathway in cultured primary hypothalamic neurons, and this effect was significantly attenuated by pretreatment with LY294002, an inhibitor of the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	236-244	apolipoprotein A4	Rattus norvegicus	20-27
29037812-2	2017	Here we report that apoA-IV treatment elicited a rapid activation of the phosphatidylinositol-3-kinase (PI3K) signaling pathway in cultured primary hypothalamic neurons, and this effect was significantly attenuated by pretreatment with LY294002, an inhibitor of the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	236-244	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	73-102
29037812-4	2017	We found that apoA-IV significantly reduced food intake and activated PI3K signaling in the hypothalamus, and these effects were abolished by icv pre-treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	apolipoprotein A4	Rattus norvegicus	14-21
29296070-9	2017	Fisetin combined with LY294002 (an inhibitor of AKT) prevented the EGF-induced migration involved in downregulation of Sp1 and MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Homo sapiens	48-51
29296070-9	2017	Fisetin combined with LY294002 (an inhibitor of AKT) prevented the EGF-induced migration involved in downregulation of Sp1 and MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	epidermal growth factor	Homo sapiens	67-70
29296070-9	2017	Fisetin combined with LY294002 (an inhibitor of AKT) prevented the EGF-induced migration involved in downregulation of Sp1 and MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	matrix metallopeptidase 9	Homo sapiens	127-132
29371922-11	2017	Enhancement of etoposide cytotoxicity by a PI-3-kinase inhibitor, LY294002, was evident in parental but was attenuated in CagA-expressing AGS cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	S100 calcium binding protein A8	Homo sapiens	122-126
28940899-9	2017	ERK1/2 inhibitor (U0126) and PI3K inhibitor (LY294002) significantly reduced LIPUS-induced phosphorylation of ERK1/2 and Akt, respectively, which in turn reduced the LIPUS-induced proliferation of hAD-MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	mitogen-activated protein kinase 3	Homo sapiens	110-116
28833753-13	2017	LY294002 inhibited TGF-beta1-mediated TE upregulation, whereas TGF-beta1 activated Akt2, but not Akt1, phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transforming growth factor beta 1	Homo sapiens	19-28
28833753-7	2017	As expected, the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the MAPK inhibitor U0126 inhibited Lf-induced phosphorylation of Akt1 and ERK1/2, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	17-46
28940899-9	2017	ERK1/2 inhibitor (U0126) and PI3K inhibitor (LY294002) significantly reduced LIPUS-induced phosphorylation of ERK1/2 and Akt, respectively, which in turn reduced the LIPUS-induced proliferation of hAD-MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	121-124
28833753-7	2017	As expected, the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the MAPK inhibitor U0126 inhibited Lf-induced phosphorylation of Akt1 and ERK1/2, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Homo sapiens	142-146
28833753-7	2017	As expected, the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the MAPK inhibitor U0126 inhibited Lf-induced phosphorylation of Akt1 and ERK1/2, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	mitogen-activated protein kinase 3	Homo sapiens	151-157
28833753-13	2017	LY294002 inhibited TGF-beta1-mediated TE upregulation, whereas TGF-beta1 activated Akt2, but not Akt1, phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	elastin	Homo sapiens	38-40
28748356-14	2017	Furthermore, the signal pathway blockers LY294002 or AG490 could block the induced expression of PD-L1 by IFN-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	CD274 molecule	Homo sapiens	97-102
29285084-8	2017	However, the protective effects induced by PTB were attenuated by LY294002, which inhibits Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
28833753-8	2017	In contrast, LY294002, but not U0126, inhibited Lf-induced TE expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	elastin	Homo sapiens	59-61
28748356-14	2017	Furthermore, the signal pathway blockers LY294002 or AG490 could block the induced expression of PD-L1 by IFN-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	interferon gamma	Homo sapiens	106-115
28983584-9	2017	The application of PD98059, an ERK inhibitor, and LY-294002, an AKT inhibitor, attenuated the protective effect induced by DRSAb in the U251 cells subjected to H/R.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	AKT serine/threonine kinase 1	Homo sapiens	64-67
28844616-8	2017	LY294002, an inhibitor of Akt activation, abrogated the phosphorylation of Akt and abolished the positive effect of miR-21 on promoting BMSCs migration and upregulating MMP-2/MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	26-29
28844616-8	2017	LY294002, an inhibitor of Akt activation, abrogated the phosphorylation of Akt and abolished the positive effect of miR-21 on promoting BMSCs migration and upregulating MMP-2/MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	75-78
28844616-8	2017	LY294002, an inhibitor of Akt activation, abrogated the phosphorylation of Akt and abolished the positive effect of miR-21 on promoting BMSCs migration and upregulating MMP-2/MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	microRNA 21	Homo sapiens	116-122
28844616-8	2017	LY294002, an inhibitor of Akt activation, abrogated the phosphorylation of Akt and abolished the positive effect of miR-21 on promoting BMSCs migration and upregulating MMP-2/MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	matrix metallopeptidase 2	Homo sapiens	169-174
28844616-8	2017	LY294002, an inhibitor of Akt activation, abrogated the phosphorylation of Akt and abolished the positive effect of miR-21 on promoting BMSCs migration and upregulating MMP-2/MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	matrix metallopeptidase 9	Homo sapiens	175-180
29110181-11	2017	Furthermore, LY294002, a specific PI3K inhibitor, reduced c-myb expression and abolished IGF-1"s protective function in SH-SY5Y cell apoptosis induced by Abeta25-35.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	MYB proto-oncogene, transcription factor	Homo sapiens	58-63
29110181-11	2017	Furthermore, LY294002, a specific PI3K inhibitor, reduced c-myb expression and abolished IGF-1"s protective function in SH-SY5Y cell apoptosis induced by Abeta25-35.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	insulin like growth factor 1	Homo sapiens	89-94
32188194-13	2017	CONCLUSION: The expression of p-Akt protein in cardiomyocytes was significantly greater in rats that were injected with LY294002 and received EA at Ximen (PC 4) compared with all other groups.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	SUB1 regulator of transcription	Rattus norvegicus	155-159
27844286-13	2017	Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, inhibited M1 marker expression; moreover, LY294002, an Akt inhibitor, enhanced M1 marker expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	thymoma viral proto-oncogene 1	Mus musculus	107-110
28983584-10	2017	Furthermore, the application of LY294002 prior to incubation with DRSAb eliminated the activation of ERK1/2, whereas the use of PD98059 failed to attenuate the effect of DRSAb on PI3K/AKT activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	mitogen-activated protein kinase 3	Homo sapiens	101-107
29344198-0	2017	Combination of cecropinXJ and LY294002 induces synergistic cytotoxicity, and apoptosis in human gastric cancer cells via inhibition of the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	144-147
29130099-6	2017	PI3K inhibitor (LY294002) or survivin inhibitor (YM155) suppressed PI3K/AKT/survivin signaling and increased the anticancer effects of miR-542-3p on the apoptosis in colon cancer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	72-75
28811223-9	2017	RESULTS: Our study showed that ALA-PDT respectively combined with AG1478, LY294002 could synergistically reduce the growth and migration ability of the Eca-109 cells in vitro and significantly down-regulate the protein expression of EGFR/PI3K and PI3K/AKT, meanwhile, significantly down-regulate the gene expression of EGFR when combining with AG1478.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	epidermal growth factor receptor	Homo sapiens	233-237
28811223-9	2017	RESULTS: Our study showed that ALA-PDT respectively combined with AG1478, LY294002 could synergistically reduce the growth and migration ability of the Eca-109 cells in vitro and significantly down-regulate the protein expression of EGFR/PI3K and PI3K/AKT, meanwhile, significantly down-regulate the gene expression of EGFR when combining with AG1478.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	252-255
28811223-9	2017	RESULTS: Our study showed that ALA-PDT respectively combined with AG1478, LY294002 could synergistically reduce the growth and migration ability of the Eca-109 cells in vitro and significantly down-regulate the protein expression of EGFR/PI3K and PI3K/AKT, meanwhile, significantly down-regulate the gene expression of EGFR when combining with AG1478.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	epidermal growth factor receptor	Homo sapiens	319-323
29296214-10	2017	Notably, PI3K inhibitor LY294002 obviously attenuated the effects of NCOA5 on p-AKT, Cyclin D1, P27 and MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	nuclear receptor coactivator 5	Homo sapiens	69-74
29196758-3	2017	Likewise, the MEK/ERK inhibitor, PD98059, and the PI3/Akt inhibitor, LY294002, showed a similar pattern.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	WAP four-disulfide core domain 15B	Rattus norvegicus	50-53
29196758-3	2017	Likewise, the MEK/ERK inhibitor, PD98059, and the PI3/Akt inhibitor, LY294002, showed a similar pattern.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
29312623-4	2017	Pretreatment with the Akt inhibitor LY294002 synergistically enhanced the R7 anti-proliferation and anti-apoptosis effects in HeLa cells, confirming that R7 acts through the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	22-25
29312623-4	2017	Pretreatment with the Akt inhibitor LY294002 synergistically enhanced the R7 anti-proliferation and anti-apoptosis effects in HeLa cells, confirming that R7 acts through the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	179-182
29021135-7	2017	Conversely, the pan-PI3K inhibitor LY294002 abrogated the growth-promoting effect of KAT6A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	lysine acetyltransferase 6A	Homo sapiens	85-90
29296214-10	2017	Notably, PI3K inhibitor LY294002 obviously attenuated the effects of NCOA5 on p-AKT, Cyclin D1, P27 and MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	80-83
29296214-10	2017	Notably, PI3K inhibitor LY294002 obviously attenuated the effects of NCOA5 on p-AKT, Cyclin D1, P27 and MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	cyclin D1	Homo sapiens	85-94
29296214-10	2017	Notably, PI3K inhibitor LY294002 obviously attenuated the effects of NCOA5 on p-AKT, Cyclin D1, P27 and MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	interferon alpha inducible protein 27	Homo sapiens	96-99
29296214-10	2017	Notably, PI3K inhibitor LY294002 obviously attenuated the effects of NCOA5 on p-AKT, Cyclin D1, P27 and MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	matrix metallopeptidase 9	Homo sapiens	104-108
29296214-11	2017	Moreover, LY294002 and knockdown of Cyclin D1 or MMP9 remarkably blocked the tumor-promoting activity of NCOA5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	nuclear receptor coactivator 5	Homo sapiens	105-110
28867181-10	2017	The phosphoinositide 3-kinase inhibitor LY294002 had an effect on insulin signaling in H9C2 cardiacmyocytes, and decreased the level of GRIM-19 by half compared with that in the insulin group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	insulin	Homo sapiens	66-73
29290940-15	2017	LPC-induced apoptosis, and IL-8 expression/secretion was attenuated by LY294002, a PI3K/Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
29290940-15	2017	LPC-induced apoptosis, and IL-8 expression/secretion was attenuated by LY294002, a PI3K/Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Homo sapiens	88-91
28847482-5	2017	Activation of IGF-1/PI3K/Akt pathway by IGF-1 abrogated the pro-apoptotic effects of esculetin, while inhibition of IGF-1/PI3K/Akt pathway by triciribine or LY294002 enhanced the pro-apoptotic effects of esculetin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	insulin like growth factor 1	Homo sapiens	14-19
28867195-4	2017	We found that the classic PI3K inhibitor LY294002 obviously inhibited the canonical mammalian target of rapamycin (mTOR) pathway and restrained the growth of ESCC with less toxicity to normal cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	mechanistic target of rapamycin kinase	Homo sapiens	84-113
28867195-4	2017	We found that the classic PI3K inhibitor LY294002 obviously inhibited the canonical mammalian target of rapamycin (mTOR) pathway and restrained the growth of ESCC with less toxicity to normal cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	mechanistic target of rapamycin kinase	Homo sapiens	115-119
28867181-10	2017	The phosphoinositide 3-kinase inhibitor LY294002 had an effect on insulin signaling in H9C2 cardiacmyocytes, and decreased the level of GRIM-19 by half compared with that in the insulin group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	insulin	Homo sapiens	178-185
28867195-5	2017	Besides, LY294002 inhibited noncanonical PKR-like ER kinase (PERK)/elF2alpha/ATF4 pathway as well.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	41-59
28867187-7	2017	Irisin-induced cell proliferation, migration, and invasion were blocked by a PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	fibronectin type III domain containing 5	Homo sapiens	0-6
28867195-5	2017	Besides, LY294002 inhibited noncanonical PKR-like ER kinase (PERK)/elF2alpha/ATF4 pathway as well.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	61-65
28867195-5	2017	Besides, LY294002 inhibited noncanonical PKR-like ER kinase (PERK)/elF2alpha/ATF4 pathway as well.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	activating transcription factor 4	Homo sapiens	77-81
28882596-5	2017	Inhibitors of PI3K, wortmannin and LY294002, and a MEK inhibitor, U0126, abolished the potentiating effect of long-term insulin treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	insulin S homeolog	Xenopus laevis	120-127
29061787-10	2017	Interestingly, the expression of P-gp was synergistically inhibited by combined treatment of U0126 with LY294002 and also inhibited by an mTORC1 inhibitor, rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	ATP binding cassette subfamily B member 1	Homo sapiens	33-37
29095886-7	2017	Treatment of ECFCs with the periostin peptide led to phosphorylation of both AKT and ERK, and pretreatment of ECFCs with the MEK-ERK pathway inhibitor U0126 or the PI3K-AKT pathway inhibitors, LY294002 or Wortmannin, blocked the periostin peptide-stimulated migration of ECFCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	periostin	Homo sapiens	28-37
29035583-11	2017	In addition, a combination of resveratrol and the PI3K/AKT inhibitor LY294002 exhibited a stronger inhibitory effect on the SKM-1 cells, compared with resveratrol alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	55-58
29035583-11	2017	In addition, a combination of resveratrol and the PI3K/AKT inhibitor LY294002 exhibited a stronger inhibitory effect on the SKM-1 cells, compared with resveratrol alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	sodium voltage-gated channel alpha subunit 4	Homo sapiens	124-129
28944825-5	2017	Additionally, PI3K/AKT/FOXO3a signaling was inhibited using Ly294002 and the effect on the protective function of mild hypothermia pretreatment was evaluated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	19-22
27774572-7	2017	The protective effect of IGF-1 was reversed by PI3K inhibitors LY294002 and wortmannin as well as the Akt inhibitor VIII.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	insulin-like growth factor 1	Mus musculus	25-30
28944825-5	2017	Additionally, PI3K/AKT/FOXO3a signaling was inhibited using Ly294002 and the effect on the protective function of mild hypothermia pretreatment was evaluated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	forkhead box O3	Homo sapiens	23-29
28944889-9	2017	Furthermore, MAE-P6 increased the expression levels of VEGFA and reduced NF-kappaB expression through Akt, which was verified by treatment with the Akt-specific inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	vascular endothelial growth factor A	Rattus norvegicus	55-60
28944825-9	2017	However, inhibiting p-AKT and p-FOXO3a using Ly294002 suppressed the liver protection produced by mild hypothermia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	22-25
28944889-9	2017	Furthermore, MAE-P6 increased the expression levels of VEGFA and reduced NF-kappaB expression through Akt, which was verified by treatment with the Akt-specific inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
28944889-9	2017	Furthermore, MAE-P6 increased the expression levels of VEGFA and reduced NF-kappaB expression through Akt, which was verified by treatment with the Akt-specific inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	AKT serine/threonine kinase 1	Rattus norvegicus	148-151
28944825-9	2017	However, inhibiting p-AKT and p-FOXO3a using Ly294002 suppressed the liver protection produced by mild hypothermia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	forkhead box O3	Homo sapiens	32-38
28884396-12	2017	Moreover, treatment with a phosphoinositol 3-kinase (PI3K) inhibitor, LY294002 (1.6 microg, i.c.v) counteracted the protective potential mediated by Re or rIL-6 against TMT insult.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	interleukin 6	Rattus norvegicus	155-160
28762104-9	2017	Co-treatment with the PI3K inhibitor LY294002 or ERK1/2 inhibitor U0126 significantly reverses the protective role of NGF on HG-induced excessive ER stress and subsequent apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	nerve growth factor	Rattus norvegicus	118-121
28785775-10	2017	LY294002 (10 muM, 30 min pretreatment), a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, significantly inhibited the T3 peptide-induced proliferation, migration, and activation of Akt signaling pathway in cardiac fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	42-67
28785775-10	2017	LY294002 (10 muM, 30 min pretreatment), a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, significantly inhibited the T3 peptide-induced proliferation, migration, and activation of Akt signaling pathway in cardiac fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	75-78
28785775-10	2017	LY294002 (10 muM, 30 min pretreatment), a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, significantly inhibited the T3 peptide-induced proliferation, migration, and activation of Akt signaling pathway in cardiac fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	181-184
28532341-9	2017	The specific inhibitor of PI3K, LY294002, successfully abrogated Pter-induced Nrf2 phosphorylation, activation of Nrf2-antioxidant response element pathway, ROS scavenging ability, and DNA repair activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82
29098037-4	2017	Although Akt phosphorylation in both cell lines was significantly attenuated by LY294002, a specific phosphoinositide 3-kinase/Akt signaling inhibitor, the levels of Akt phosphorylation following treatment with LY294002 were higher in CYP2J2-overexpressing HepG2 cells than in wild-type HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	235-241
29098037-5	2017	Cell counting revealed that proliferation was reduced by LY294002 in both cell lines; however, CYP2J2-overexpressing HepG2 cell numbers were higher than those of wild-type HepG2 cells following treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	209-217	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	95-101
29113186-12	2017	Notably, the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 abrogated the decreased phosphorylation of Akt, suggesting that the PI3K/Akt signaling pathway is involved in mediating the anticancer effects of puerarin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	112-115
29113186-12	2017	Notably, the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 abrogated the decreased phosphorylation of Akt, suggesting that the PI3K/Akt signaling pathway is involved in mediating the anticancer effects of puerarin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	142-145
28532341-9	2017	The specific inhibitor of PI3K, LY294002, successfully abrogated Pter-induced Nrf2 phosphorylation, activation of Nrf2-antioxidant response element pathway, ROS scavenging ability, and DNA repair activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
29017592-16	2017	Furthermore, omentin-1 enhanced Akt phosphorylation; however, blockade of the PI3K/Akt pathway with an inhibitor, LY294002 (20 muM), suppressed the above beneficial effects of omentin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Homo sapiens	83-86
29075038-4	2017	PPD activated both PI3K/Akt/mTOR and Raf/MEK/ERK signaling pathways in HUVECs, which were abrogated by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	thymoma viral proto-oncogene 1	Mus musculus	24-27
29075038-4	2017	PPD activated both PI3K/Akt/mTOR and Raf/MEK/ERK signaling pathways in HUVECs, which were abrogated by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	mechanistic target of rapamycin kinase	Mus musculus	28-32
29075038-4	2017	PPD activated both PI3K/Akt/mTOR and Raf/MEK/ERK signaling pathways in HUVECs, which were abrogated by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	zinc fingers and homeoboxes 2	Mus musculus	37-40
29075038-4	2017	PPD activated both PI3K/Akt/mTOR and Raf/MEK/ERK signaling pathways in HUVECs, which were abrogated by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	midkine	Mus musculus	41-44
29075038-4	2017	PPD activated both PI3K/Akt/mTOR and Raf/MEK/ERK signaling pathways in HUVECs, which were abrogated by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	mitogen-activated protein kinase 1	Mus musculus	45-48
29075038-5	2017	Furthermore, these two pathways had crosstalk through p70S6K, as LY294002, PD98059 and p70S6K siRNA abolished the angiogenic responses of PPD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	54-60
29245957-5	2017	In addition, LC3-II and p-Akt was suppressed in the presence of LY294002, a well-known inhibitor of P13K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Homo sapiens	26-29
29262646-10	2017	However, when treated with LY294002, the expression of HIF-1alpha and VEGF both decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	hypoxia inducible factor 1, alpha subunit	Mus musculus	55-65
29262646-10	2017	However, when treated with LY294002, the expression of HIF-1alpha and VEGF both decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	vascular endothelial growth factor A	Mus musculus	70-74
29053747-9	2017	Treatment of pten dko embryos with the PI3K inhibitor LY294002 reduced the pAKT/AKT ratio by about one-half and partially rescued the defect in vasculogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	Oryzias latipes	13-17
28807764-6	2017	However, SEC2/ST-4-induced changes in cell cycle and PI3K/mTOR signaling were significantly relieved by either LY294002 or rapamycin, and the induction of NF-kB/p65 induced was significantly downregulated by Bay11-7085.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	fucosyltransferase 2	Homo sapiens	9-13
28807764-6	2017	However, SEC2/ST-4-induced changes in cell cycle and PI3K/mTOR signaling were significantly relieved by either LY294002 or rapamycin, and the induction of NF-kB/p65 induced was significantly downregulated by Bay11-7085.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	14-18
28807764-6	2017	However, SEC2/ST-4-induced changes in cell cycle and PI3K/mTOR signaling were significantly relieved by either LY294002 or rapamycin, and the induction of NF-kB/p65 induced was significantly downregulated by Bay11-7085.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	mechanistic target of rapamycin kinase	Homo sapiens	58-62
28981091-6	2017	On another hand, inhibiting the PI3K/Akt pathway with LY294002 partially reversed the therapeutic effects of FGF10.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	37-40
28981091-6	2017	On another hand, inhibiting the PI3K/Akt pathway with LY294002 partially reversed the therapeutic effects of FGF10.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	fibroblast growth factor 10	Homo sapiens	109-114
28798142-9	2017	Using LY294002, a PI3K/Akt inhibitor, we found that PI3K/Akt-mediated Mdm2 phosphorylation and activation was inhibited in senescent or SM22alpha-overexpressed VSMCs, in parallel with decreased p53 ubiquitination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	thymoma viral proto-oncogene 1	Mus musculus	23-26
28972999-8	2017	The PI3K inhibitor LY294002 blocked IGF-II, but not IGF-I, induction of pax3 mRNA as well as the IGF-I, but not IGF-II, induction of MyoD mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	IGFII	Gallus gallus	36-42
28972999-8	2017	The PI3K inhibitor LY294002 blocked IGF-II, but not IGF-I, induction of pax3 mRNA as well as the IGF-I, but not IGF-II, induction of MyoD mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	IGF-I	Gallus gallus	36-41
28972999-8	2017	The PI3K inhibitor LY294002 blocked IGF-II, but not IGF-I, induction of pax3 mRNA as well as the IGF-I, but not IGF-II, induction of MyoD mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	paired box 3	Gallus gallus	72-76
28798142-9	2017	Using LY294002, a PI3K/Akt inhibitor, we found that PI3K/Akt-mediated Mdm2 phosphorylation and activation was inhibited in senescent or SM22alpha-overexpressed VSMCs, in parallel with decreased p53 ubiquitination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	transformation related protein 53, pseudogene	Mus musculus	194-197
28708672-8	2017	Treatment of LNCaP cells with the PI3-kinase inhibitor LY294002, which inhibits the PI3-kinase-dependent activation of AKT-1, prevented the artemisinin-induced AR degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	119-124
28708672-8	2017	Treatment of LNCaP cells with the PI3-kinase inhibitor LY294002, which inhibits the PI3-kinase-dependent activation of AKT-1, prevented the artemisinin-induced AR degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	androgen receptor	Homo sapiens	160-162
28798142-9	2017	Using LY294002, a PI3K/Akt inhibitor, we found that PI3K/Akt-mediated Mdm2 phosphorylation and activation was inhibited in senescent or SM22alpha-overexpressed VSMCs, in parallel with decreased p53 ubiquitination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	thymoma viral proto-oncogene 1	Mus musculus	57-60
28798142-9	2017	Using LY294002, a PI3K/Akt inhibitor, we found that PI3K/Akt-mediated Mdm2 phosphorylation and activation was inhibited in senescent or SM22alpha-overexpressed VSMCs, in parallel with decreased p53 ubiquitination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	transformed mouse 3T3 cell double minute 2	Mus musculus	70-74
28798142-9	2017	Using LY294002, a PI3K/Akt inhibitor, we found that PI3K/Akt-mediated Mdm2 phosphorylation and activation was inhibited in senescent or SM22alpha-overexpressed VSMCs, in parallel with decreased p53 ubiquitination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	transgelin	Mus musculus	136-145
28220374-6	2017	In CF, LPS treatment decreased the protein levels of alpha-SMA, and this effect was prevented by TAK-242 (TLR4 inhibitor) and LY294002 (Akt inhibitor), but not by BAY 11-7082 (NF-kappabeta inhibitor) and PD98059 (ERK1/2 inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	actin gamma 2, smooth muscle	Rattus norvegicus	53-62
27665947-10	2017	Both Ly294002 and AG490 promoted downregulation of surface CXCR4 expression on B cells from SLE patients (P=0.078 and P=0.064).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	C-X-C motif chemokine receptor 4	Homo sapiens	59-64
28220374-6	2017	In CF, LPS treatment decreased the protein levels of alpha-SMA, and this effect was prevented by TAK-242 (TLR4 inhibitor) and LY294002 (Akt inhibitor), but not by BAY 11-7082 (NF-kappabeta inhibitor) and PD98059 (ERK1/2 inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	AKT serine/threonine kinase 1	Rattus norvegicus	136-139
28807874-7	2017	LY294002, a PI3K inhibitor, suppressed DHA-induced OSGIN1 protein expression and nuclear accumulation of Nrf2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	oxidative stress induced growth inhibitor 1	Homo sapiens	51-57
28762597-11	2017	LY294002 can decrease the expression of multidrug resistance protein-1 (MRP1) in NSCLC Dox-resistant cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	40-70
28762597-11	2017	LY294002 can decrease the expression of multidrug resistance protein-1 (MRP1) in NSCLC Dox-resistant cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	72-76
29043002-9	2017	Similar to FLLL32, Jak2/Stat3 signaling activated by HNG was also repressed by inhibitor of phosphoinositide 3-kinase (PI3K; 10 microM LY294002) or protein kinase B (AKT; 5 microM MK-2206 2HCl).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	Janus kinase 2	Homo sapiens	19-23
29043002-9	2017	Similar to FLLL32, Jak2/Stat3 signaling activated by HNG was also repressed by inhibitor of phosphoinositide 3-kinase (PI3K; 10 microM LY294002) or protein kinase B (AKT; 5 microM MK-2206 2HCl).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	signal transducer and activator of transcription 3	Homo sapiens	24-29
28757460-8	2017	PI3K/AKT inhibitor (LY294002) and HO-1inhibitor (ZnPP-IX) both increased olaquindox-induced apoptosis and S-phase arrest.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	5-8
28807874-7	2017	LY294002, a PI3K inhibitor, suppressed DHA-induced OSGIN1 protein expression and nuclear accumulation of Nrf2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
28694172-12	2017	Furthermore, ERK inhibitor PD98059 or PI3K inhibitor LY294002 significantly reversed the effects of Si-MIF on PVM/Ms from young mice, whereas ERK activator EGF or PI3K activator IGF significantly reversed the effects of Ad-MIF on PVM/Ms from aged mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	103-106
29171427-6	2017	Intracerebroventricular injection of the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1, and weakened the associated neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Rattus norvegicus	90-93
29171427-6	2017	Intracerebroventricular injection of the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1, and weakened the associated neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Rattus norvegicus	175-178
29171427-6	2017	Intracerebroventricular injection of the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1, and weakened the associated neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	solute carrier family 1 member 2	Rattus norvegicus	183-206
29171438-6	2017	Additionally, preincubation with either JAK2 inhibitor AG490 or PI3K inhibitor LY294002 blocked the neuroprotective effect of ciliary neurotrophic factor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	ciliary neurotrophic factor	Rattus norvegicus	126-153
28633978-7	2017	Further, both PI3K inhibitor (LY294002) and Akt inhibitor (MK-2206) reversed the elevated TNF-alpha expression to control level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	tumor necrosis factor	Homo sapiens	90-99
28902361-6	2017	Furthermore, we found that the combination of the HER2 inhibitor (CP-724714) and pan PI3K inhibitor (LY294002) is more potent than either inhibitor alone in terms of inhibition of cell proliferation and colony formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	erb-b2 receptor tyrosine kinase 2	Homo sapiens	50-54
28624893-6	2017	LY294002 treatment significantly reduced IL-6, IL-1beta and TNF-alpha in serum and striatum of TS rats, Also, highly expressed P-PI3K, P-Akt, P-NF-kappaBp65, P-IkappaBalpha in TS rats were restored respectively by LY294002 treatment as indicted in western blot analysis and immunohistochemistry analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 6	Rattus norvegicus	41-45
28624893-6	2017	LY294002 treatment significantly reduced IL-6, IL-1beta and TNF-alpha in serum and striatum of TS rats, Also, highly expressed P-PI3K, P-Akt, P-NF-kappaBp65, P-IkappaBalpha in TS rats were restored respectively by LY294002 treatment as indicted in western blot analysis and immunohistochemistry analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 alpha	Rattus norvegicus	47-55
28624893-6	2017	LY294002 treatment significantly reduced IL-6, IL-1beta and TNF-alpha in serum and striatum of TS rats, Also, highly expressed P-PI3K, P-Akt, P-NF-kappaBp65, P-IkappaBalpha in TS rats were restored respectively by LY294002 treatment as indicted in western blot analysis and immunohistochemistry analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Rattus norvegicus	60-69
28624893-6	2017	LY294002 treatment significantly reduced IL-6, IL-1beta and TNF-alpha in serum and striatum of TS rats, Also, highly expressed P-PI3K, P-Akt, P-NF-kappaBp65, P-IkappaBalpha in TS rats were restored respectively by LY294002 treatment as indicted in western blot analysis and immunohistochemistry analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	137-140
28624893-7	2017	Thus, it was supposed that the protective effect of LY294002 against TS in rat might be associated with the regulation of PI3K/Akt/NF-B pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Rattus norvegicus	127-130
29071206-6	2017	The cell viability, migration and invasion ability of U2-OS cells were significantly increased by ERbeta siRNA, but inhibited by ERbeta agonists LY294002 (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	estrogen receptor 2	Homo sapiens	129-135
29071206-8	2017	The expression of p-p65, p-AKT and Bcl-2 was significantly reduced by LY294002, but increased by ERbeta siRNA (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	RELA proto-oncogene, NF-kB subunit	Homo sapiens	20-23
29071206-8	2017	The expression of p-p65, p-AKT and Bcl-2 was significantly reduced by LY294002, but increased by ERbeta siRNA (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Homo sapiens	27-30
29071206-8	2017	The expression of p-p65, p-AKT and Bcl-2 was significantly reduced by LY294002, but increased by ERbeta siRNA (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	BCL2 apoptosis regulator	Homo sapiens	35-40
28993734-4	2017	Besides, the cells were incubated with or without LY294002 as inhibitor of phosphatidylinositol 3-kinase (PI3K) under OGD/R condition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	75-104
28738535-9	2017	LY294002, which is an effective inhibitor of the PI3K/AKT signaling pathway, partly inhibited GAB1 to suppress apoptosis induced by HG in cardiomyocytes, and partly suppressed GAB1 to resist the decrease of XIAP in response to HG, indicating AKT signaling, XIAP, and Caspase3/7 participated in GAB1-mediated cardiomyocyte apoptosis in response to HG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
28256185-8	2017	These effects were inversed after pretreatment of the PI3K/Akt inhibitor LY294002 or overexpression of constitutively active Akt1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	thymoma viral proto-oncogene 1	Mus musculus	59-62
28712871-3	2017	Inhibitory experiments using a PI3K selective inhibitor, LY294002 or NVP-BEZ235, significantly enhanced the BITC-induced antiproliferation and apoptotic cell population with the attenuation of the BITC-induced activation of the PI3K/Akt/FoxO survival pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	233-236
28645007-7	2017	Decreased mRNA and protein expressions of PI3K and Bcl-2, reduced protein expressions of p-Akt and p-Bad and elevated mRNA and protein expressions of Bax exhibited in the LY294002 group than the DADLE group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	BCL2, apoptosis regulator	Rattus norvegicus	51-56
28645007-7	2017	Decreased mRNA and protein expressions of PI3K and Bcl-2, reduced protein expressions of p-Akt and p-Bad and elevated mRNA and protein expressions of Bax exhibited in the LY294002 group than the DADLE group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	BCL2 associated X, apoptosis regulator	Rattus norvegicus	150-153
28774557-8	2017	LY29400 (inhibitor of PI3K) abrogated the activation of PI3K/AKT and SB203580 (inhibitor of P38) abolished the inhibition of FGF21 on P38, while alteration was observed in the expression of RUNX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-7	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
28774557-8	2017	LY29400 (inhibitor of PI3K) abrogated the activation of PI3K/AKT and SB203580 (inhibitor of P38) abolished the inhibition of FGF21 on P38, while alteration was observed in the expression of RUNX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-7	fibroblast growth factor 21	Rattus norvegicus	125-130
28774557-8	2017	LY29400 (inhibitor of PI3K) abrogated the activation of PI3K/AKT and SB203580 (inhibitor of P38) abolished the inhibition of FGF21 on P38, while alteration was observed in the expression of RUNX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-7	mitogen activated protein kinase 14	Rattus norvegicus	134-137
28774557-8	2017	LY29400 (inhibitor of PI3K) abrogated the activation of PI3K/AKT and SB203580 (inhibitor of P38) abolished the inhibition of FGF21 on P38, while alteration was observed in the expression of RUNX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-7	RUNX family transcription factor 2	Rattus norvegicus	190-196
29163781-6	2017	SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	synaptojanin 2 binding protein	Mus musculus	0-7
29163781-6	2017	SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	thymoma viral proto-oncogene 1	Mus musculus	52-55
29163781-6	2017	SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	glycogen synthase kinase 3 beta	Mus musculus	60-68
29163781-6	2017	SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	snail family zinc finger 1	Mus musculus	196-201
29163781-6	2017	SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	snail family zinc finger 1	Mus musculus	243-248
29163781-6	2017	SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	cadherin 1	Mus musculus	262-272
29163781-6	2017	SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	IL2 inducible T cell kinase	Mus musculus	274-277
28738539-8	2017	Finally, results of studies which used an agonist (740Y-P) and an inhibitor (LY294002) of the PI3K/AKT signaling pathway, as well as the results of western blot assays, indicated that lncRNA AB073614 exerts its effects by targeting the PI3K/AKT-mediated signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	99-102
28738535-9	2017	LY294002, which is an effective inhibitor of the PI3K/AKT signaling pathway, partly inhibited GAB1 to suppress apoptosis induced by HG in cardiomyocytes, and partly suppressed GAB1 to resist the decrease of XIAP in response to HG, indicating AKT signaling, XIAP, and Caspase3/7 participated in GAB1-mediated cardiomyocyte apoptosis in response to HG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GRB2-associated binding protein 1	Rattus norvegicus	94-98
28738535-9	2017	LY294002, which is an effective inhibitor of the PI3K/AKT signaling pathway, partly inhibited GAB1 to suppress apoptosis induced by HG in cardiomyocytes, and partly suppressed GAB1 to resist the decrease of XIAP in response to HG, indicating AKT signaling, XIAP, and Caspase3/7 participated in GAB1-mediated cardiomyocyte apoptosis in response to HG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GRB2-associated binding protein 1	Rattus norvegicus	176-180
28738535-9	2017	LY294002, which is an effective inhibitor of the PI3K/AKT signaling pathway, partly inhibited GAB1 to suppress apoptosis induced by HG in cardiomyocytes, and partly suppressed GAB1 to resist the decrease of XIAP in response to HG, indicating AKT signaling, XIAP, and Caspase3/7 participated in GAB1-mediated cardiomyocyte apoptosis in response to HG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	X-linked inhibitor of apoptosis	Rattus norvegicus	207-211
28738535-9	2017	LY294002, which is an effective inhibitor of the PI3K/AKT signaling pathway, partly inhibited GAB1 to suppress apoptosis induced by HG in cardiomyocytes, and partly suppressed GAB1 to resist the decrease of XIAP in response to HG, indicating AKT signaling, XIAP, and Caspase3/7 participated in GAB1-mediated cardiomyocyte apoptosis in response to HG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	242-245
28738535-9	2017	LY294002, which is an effective inhibitor of the PI3K/AKT signaling pathway, partly inhibited GAB1 to suppress apoptosis induced by HG in cardiomyocytes, and partly suppressed GAB1 to resist the decrease of XIAP in response to HG, indicating AKT signaling, XIAP, and Caspase3/7 participated in GAB1-mediated cardiomyocyte apoptosis in response to HG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	X-linked inhibitor of apoptosis	Rattus norvegicus	257-261
28738535-9	2017	LY294002, which is an effective inhibitor of the PI3K/AKT signaling pathway, partly inhibited GAB1 to suppress apoptosis induced by HG in cardiomyocytes, and partly suppressed GAB1 to resist the decrease of XIAP in response to HG, indicating AKT signaling, XIAP, and Caspase3/7 participated in GAB1-mediated cardiomyocyte apoptosis in response to HG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Rattus norvegicus	267-275
28738535-9	2017	LY294002, which is an effective inhibitor of the PI3K/AKT signaling pathway, partly inhibited GAB1 to suppress apoptosis induced by HG in cardiomyocytes, and partly suppressed GAB1 to resist the decrease of XIAP in response to HG, indicating AKT signaling, XIAP, and Caspase3/7 participated in GAB1-mediated cardiomyocyte apoptosis in response to HG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GRB2-associated binding protein 1	Rattus norvegicus	176-180
28734031-12	2017	Interestingly, LY294002, an inhibitor of PI3K/Akt signaling, aggravated, whereas LiCl, an activator of Wnt/beta-catenin signaling, abolished the reduction in DEC1 by MPP+ .	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	thymoma viral proto-oncogene 1	Mus musculus	46-49
28551414-5	2017	LY294002 (an inhibitor of AKT) decreased SCF-induced p-AKT, p-P70RSK and p-RPS6 proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Sus scrofa	26-29
28587873-6	2017	Suppression of endogenous PI3K/Akt activity during colitis or NGF treatment with a specific PI3K inhibitor LY294002 reduced TRPV1 protein production in DRG neurons, and also reduced colitis-evoked TRPV1-mediated visceral hypersensitivity tested by hyper-responsiveness to colorectal distention (CRD) and von Frey filament stimulation of abdomen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	AKT serine/threonine kinase 1	Homo sapiens	31-34
28587873-6	2017	Suppression of endogenous PI3K/Akt activity during colitis or NGF treatment with a specific PI3K inhibitor LY294002 reduced TRPV1 protein production in DRG neurons, and also reduced colitis-evoked TRPV1-mediated visceral hypersensitivity tested by hyper-responsiveness to colorectal distention (CRD) and von Frey filament stimulation of abdomen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	transient receptor potential cation channel subfamily V member 1	Homo sapiens	124-129
28587873-6	2017	Suppression of endogenous PI3K/Akt activity during colitis or NGF treatment with a specific PI3K inhibitor LY294002 reduced TRPV1 protein production in DRG neurons, and also reduced colitis-evoked TRPV1-mediated visceral hypersensitivity tested by hyper-responsiveness to colorectal distention (CRD) and von Frey filament stimulation of abdomen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	transient receptor potential cation channel subfamily V member 1	Homo sapiens	197-202
28551414-5	2017	LY294002 (an inhibitor of AKT) decreased SCF-induced p-AKT, p-P70RSK and p-RPS6 proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	KIT ligand	Sus scrofa	41-44
28551414-5	2017	LY294002 (an inhibitor of AKT) decreased SCF-induced p-AKT, p-P70RSK and p-RPS6 proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Sus scrofa	55-58
28551414-5	2017	LY294002 (an inhibitor of AKT) decreased SCF-induced p-AKT, p-P70RSK and p-RPS6 proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribosomal protein S6	Sus scrofa	75-79
28551414-6	2017	Also, immunofluorescence analyses revealed that p-RPS6 was abundant within the cytoplasm of SCF-treated cells, but p-RPS6 was present only at basal levels in cells treated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	ribosomal protein S6	Sus scrofa	117-121
28551414-7	2017	In the presence of LY294002, both SCF-stimulated transient and sustained AKT phosphorylation were inhibited in pLE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	KIT ligand	Sus scrofa	34-37
28551414-7	2017	In the presence of LY294002, both SCF-stimulated transient and sustained AKT phosphorylation were inhibited in pLE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Sus scrofa	73-76
28551414-8	2017	Furthermore, SCF increased migration of pTr and pLE cells, but LY294002 significantly reduced this effect of SCF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	KIT ligand	Sus scrofa	109-112
28677733-9	2017	Moreover, treatment with LY294002, a PI3K/PKB inhibitor, was able to slightly repress IFN-gamma-induced expressions of MIG and I-TAC, but not IP-10, in INS-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	interferon gamma	Rattus norvegicus	86-95
31966870-7	2017	The expression of MMP9 and MMP2 was decreased when PI3K/AKT signaling inhibitor LY294002 and NF-kappaB inhibitor PDTC were used respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	matrix metallopeptidase 9	Homo sapiens	18-22
28677733-9	2017	Moreover, treatment with LY294002, a PI3K/PKB inhibitor, was able to slightly repress IFN-gamma-induced expressions of MIG and I-TAC, but not IP-10, in INS-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	C-X-C motif chemokine ligand 9	Rattus norvegicus	119-122
31966870-7	2017	The expression of MMP9 and MMP2 was decreased when PI3K/AKT signaling inhibitor LY294002 and NF-kappaB inhibitor PDTC were used respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	matrix metallopeptidase 2	Homo sapiens	27-31
31966870-7	2017	The expression of MMP9 and MMP2 was decreased when PI3K/AKT signaling inhibitor LY294002 and NF-kappaB inhibitor PDTC were used respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	56-59
28677733-9	2017	Moreover, treatment with LY294002, a PI3K/PKB inhibitor, was able to slightly repress IFN-gamma-induced expressions of MIG and I-TAC, but not IP-10, in INS-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	C-X-C motif chemokine ligand 10	Rattus norvegicus	142-147
31966870-8	2017	Moreover the migrated of CXCR4 overexpressed MSCs and CXCR4 overexpressed SPION labeled MSCs were significantly reduced after LY294002 and PDTC used.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	C-X-C motif chemokine receptor 4	Homo sapiens	25-30
31966870-8	2017	Moreover the migrated of CXCR4 overexpressed MSCs and CXCR4 overexpressed SPION labeled MSCs were significantly reduced after LY294002 and PDTC used.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	C-X-C motif chemokine receptor 4	Homo sapiens	54-59
28766684-7	2017	Moreover, the induction of PTEN attenuated the Akt phosphorylation levels, pretreatment of PI3K inhibitor LY294002 in NB4 cells, significantly augmented the cell differentiation and increased the expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	phosphatase and tensin homolog	Homo sapiens	27-31
28766684-7	2017	Moreover, the induction of PTEN attenuated the Akt phosphorylation levels, pretreatment of PI3K inhibitor LY294002 in NB4 cells, significantly augmented the cell differentiation and increased the expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	phosphatase and tensin homolog	Homo sapiens	210-214
28677733-9	2017	Moreover, treatment with LY294002, a PI3K/PKB inhibitor, was able to slightly repress IFN-gamma-induced expressions of MIG and I-TAC, but not IP-10, in INS-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	insulin 1	Rattus norvegicus	152-157
28271613-9	2017	Similarly, LY294002 interrupted the beneficial effects of QL with down-regulated phospho-Akt, phospho-mTOR, HIF-1alpha and VEGF expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	AKT serine/threonine kinase 1	Homo sapiens	89-92
27608275-9	2017	Interestingly, pre-treatment with the PI3K inhibitor LY294002 reversed the stimulatory effects of rCT-1 on apelin expression, suggesting that this pathway could be mediating the effects of rCT-1 on apelin production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	cardiotrophin 1	Rattus norvegicus	98-103
27608275-9	2017	Interestingly, pre-treatment with the PI3K inhibitor LY294002 reversed the stimulatory effects of rCT-1 on apelin expression, suggesting that this pathway could be mediating the effects of rCT-1 on apelin production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	cardiotrophin 1	Rattus norvegicus	189-194
28271613-9	2017	Similarly, LY294002 interrupted the beneficial effects of QL with down-regulated phospho-Akt, phospho-mTOR, HIF-1alpha and VEGF expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	mechanistic target of rapamycin kinase	Homo sapiens	102-106
28271613-9	2017	Similarly, LY294002 interrupted the beneficial effects of QL with down-regulated phospho-Akt, phospho-mTOR, HIF-1alpha and VEGF expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-118
28271613-9	2017	Similarly, LY294002 interrupted the beneficial effects of QL with down-regulated phospho-Akt, phospho-mTOR, HIF-1alpha and VEGF expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	vascular endothelial growth factor A	Homo sapiens	123-127
28601977-6	2017	Furthermore, the protective effect can be abolished by PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
28019025-6	2017	Furthermore, Akt inhibitor LY294002 treatment resulted in neuronal polarization delay and axon outgrowth retardation, while suppressing the phosphorylation and nuclear translocation of p65.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
28019025-6	2017	Furthermore, Akt inhibitor LY294002 treatment resulted in neuronal polarization delay and axon outgrowth retardation, while suppressing the phosphorylation and nuclear translocation of p65.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	synaptotagmin 1	Rattus norvegicus	185-188
28677724-9	2017	On a molecular mechanism level, TNFR2 significantly affected the phosphorylation of AKT serine/threonine kinase 1 (AKT) in both cell lines, and treatment with the AKT inhibitor LY294002 effectively abrogated TNFR2-induced PARP expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	TNF receptor superfamily member 1B	Homo sapiens	32-37
28677724-9	2017	On a molecular mechanism level, TNFR2 significantly affected the phosphorylation of AKT serine/threonine kinase 1 (AKT) in both cell lines, and treatment with the AKT inhibitor LY294002 effectively abrogated TNFR2-induced PARP expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	AKT serine/threonine kinase 1	Homo sapiens	84-113
28677724-9	2017	On a molecular mechanism level, TNFR2 significantly affected the phosphorylation of AKT serine/threonine kinase 1 (AKT) in both cell lines, and treatment with the AKT inhibitor LY294002 effectively abrogated TNFR2-induced PARP expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	AKT serine/threonine kinase 1	Homo sapiens	84-87
28677724-9	2017	On a molecular mechanism level, TNFR2 significantly affected the phosphorylation of AKT serine/threonine kinase 1 (AKT) in both cell lines, and treatment with the AKT inhibitor LY294002 effectively abrogated TNFR2-induced PARP expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	AKT serine/threonine kinase 1	Homo sapiens	115-118
28677724-9	2017	On a molecular mechanism level, TNFR2 significantly affected the phosphorylation of AKT serine/threonine kinase 1 (AKT) in both cell lines, and treatment with the AKT inhibitor LY294002 effectively abrogated TNFR2-induced PARP expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	TNF receptor superfamily member 1B	Homo sapiens	208-213
28677724-9	2017	On a molecular mechanism level, TNFR2 significantly affected the phosphorylation of AKT serine/threonine kinase 1 (AKT) in both cell lines, and treatment with the AKT inhibitor LY294002 effectively abrogated TNFR2-induced PARP expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	poly(ADP-ribose) polymerase 1	Homo sapiens	222-226
28713974-8	2017	In addition, downregulation of miR-125b combined with the PI3K inhibitor LY294002 enhanced cell growth inhibition, suppression of p-GSK3beta, Wnt and beta-catenin protein expression and promotion of caspase-3 activity in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	glycogen synthase kinase 3 beta	Homo sapiens	132-140
28713974-8	2017	In addition, downregulation of miR-125b combined with the PI3K inhibitor LY294002 enhanced cell growth inhibition, suppression of p-GSK3beta, Wnt and beta-catenin protein expression and promotion of caspase-3 activity in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	catenin beta 1	Homo sapiens	150-162
28927052-0	2017	Synergistic effects of phenylhexyl isothiocyanate and LY294002 on the PI3K/Akt signaling pathway in HL-60 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	75-78
28731179-5	2017	LY294002, an inhibitor of PI3K, suppressed PI3K/AKT/mTOR signaling, induced apoptosis, inhibited cell proliferation, increased caspase-3 and Bax protein expression, and decreased PDK1 protein expression in A2058 cells following miR-138 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	48-51
28731179-5	2017	LY294002, an inhibitor of PI3K, suppressed PI3K/AKT/mTOR signaling, induced apoptosis, inhibited cell proliferation, increased caspase-3 and Bax protein expression, and decreased PDK1 protein expression in A2058 cells following miR-138 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	52-56
28731179-5	2017	LY294002, an inhibitor of PI3K, suppressed PI3K/AKT/mTOR signaling, induced apoptosis, inhibited cell proliferation, increased caspase-3 and Bax protein expression, and decreased PDK1 protein expression in A2058 cells following miR-138 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Homo sapiens	127-136
28731179-5	2017	LY294002, an inhibitor of PI3K, suppressed PI3K/AKT/mTOR signaling, induced apoptosis, inhibited cell proliferation, increased caspase-3 and Bax protein expression, and decreased PDK1 protein expression in A2058 cells following miR-138 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	141-144
28731179-5	2017	LY294002, an inhibitor of PI3K, suppressed PI3K/AKT/mTOR signaling, induced apoptosis, inhibited cell proliferation, increased caspase-3 and Bax protein expression, and decreased PDK1 protein expression in A2058 cells following miR-138 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	pyruvate dehydrogenase kinase 1	Homo sapiens	179-183
29130665-8	2017	1H7 and LY294002 decreased the expression of PI3K and pAkt protein,but no obvious inhibitory effect on total Akt protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	AKT serine/threonine kinase 1	Homo sapiens	55-58
28927052-1	2017	The aim of the present study was to investigate the synergistic effect of phenylhexyl isothiocyanate (PHI) and LY294002 [an inhibitor of phosphoinositide 3-kinase (PI3K)] on the PI3K/protein kinase B (Akt) signaling pathway, modulating histone acetylation, inhibiting cell viability and inducing apoptosis in HL-60 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Homo sapiens	201-204
28927052-9	2017	PHI and/or LY294002 were identified to dephosphorylate proteins in the PI3K/Akt signaling pathway, with a synergistic effect observed when used in combination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	AKT serine/threonine kinase 1	Homo sapiens	76-79
28733141-9	2017	When Ly294002 was added with GRP, it prevented the GRP-induced increased cell invasiveness (p&lt;0.001).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	gastrin releasing peptide	Mus musculus	29-32
28733141-9	2017	When Ly294002 was added with GRP, it prevented the GRP-induced increased cell invasiveness (p&lt;0.001).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	gastrin releasing peptide	Mus musculus	51-54
28713974-8	2017	In addition, downregulation of miR-125b combined with the PI3K inhibitor LY294002 enhanced cell growth inhibition, suppression of p-GSK3beta, Wnt and beta-catenin protein expression and promotion of caspase-3 activity in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	caspase 3	Homo sapiens	199-208
28739349-7	2017	Following administration of the PI3K-specific inhibitor LY294002, the phosphorylation levels of Akt and mTOR decreased, and the ratio of autophagy-specific protein microtubule-associated protein 1 light chain (LC3)II/I was higher in the inhibitor-treated injury group than in the simple-injury group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	96-99
28739349-7	2017	Following administration of the PI3K-specific inhibitor LY294002, the phosphorylation levels of Akt and mTOR decreased, and the ratio of autophagy-specific protein microtubule-associated protein 1 light chain (LC3)II/I was higher in the inhibitor-treated injury group than in the simple-injury group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	mechanistic target of rapamycin kinase	Homo sapiens	104-108
28462510-8	2017	In addition, Runx2 could upregulate the expression of osteogenic-related genes and increase matrix mineralization, while applying 10 microM PI3K/AKT inhibitor LY294002 abolished the beneficial effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
29069835-4	2017	Importantly, pre-treatment of cells with PI3K inhibitor (Ly294002) or prior silencing of beta-catenin with siRNA blocked 5-HT-induced PPAR gamma reduction and PASMCs proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	peroxisome proliferator activated receptor gamma	Homo sapiens	134-144
29088824-9	2017	Additionally, LY294002 abolished the stimulatory effect of DATS on AKT/GSK-3beta/HIF-1alpha signaling without affecting AMPK signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Rattus norvegicus	67-70
29088824-9	2017	Additionally, LY294002 abolished the stimulatory effect of DATS on AKT/GSK-3beta/HIF-1alpha signaling without affecting AMPK signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	glycogen synthase kinase 3 beta	Rattus norvegicus	71-80
29088824-9	2017	Additionally, LY294002 abolished the stimulatory effect of DATS on AKT/GSK-3beta/HIF-1alpha signaling without affecting AMPK signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	81-91
29245906-10	2017	The PI3K-specific inhibitor LY294002 reduced these cardioprotective effects, indicating that they were attributable to the activation of the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	146-149
28771227-6	2017	In addition, Klotho reduced Tac-induced mitochondrial dysfunction and decreased mitochondrial reactive oxygen species production, and these effects were enhanced by blocking PI3K activity with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	klotho	Homo sapiens	13-19
28618656-10	2017	HMGB1-induced proliferation of HSCs and up-regulation of COL1A1 and alpha-SMA was reversed in the presence of LY294002, an inhibitor of PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	high mobility group box 1	Rattus norvegicus	0-5
28612103-10	2017	Furthermore, DMY might activate the Nrf2/HO-1 pathway through activation of the Akt and ERK1/2 pathways, as shown by the inhibition of Nrf2/HO-1 signaling by the inhibitors PD98059 or LY294002 and the transfection of ERK, Akt siRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
28612103-10	2017	Furthermore, DMY might activate the Nrf2/HO-1 pathway through activation of the Akt and ERK1/2 pathways, as shown by the inhibition of Nrf2/HO-1 signaling by the inhibitors PD98059 or LY294002 and the transfection of ERK, Akt siRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	heme oxygenase 1	Homo sapiens	41-45
28612103-10	2017	Furthermore, DMY might activate the Nrf2/HO-1 pathway through activation of the Akt and ERK1/2 pathways, as shown by the inhibition of Nrf2/HO-1 signaling by the inhibitors PD98059 or LY294002 and the transfection of ERK, Akt siRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
28612103-10	2017	Furthermore, DMY might activate the Nrf2/HO-1 pathway through activation of the Akt and ERK1/2 pathways, as shown by the inhibition of Nrf2/HO-1 signaling by the inhibitors PD98059 or LY294002 and the transfection of ERK, Akt siRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	heme oxygenase 1	Homo sapiens	140-144
28618656-10	2017	HMGB1-induced proliferation of HSCs and up-regulation of COL1A1 and alpha-SMA was reversed in the presence of LY294002, an inhibitor of PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	collagen type I alpha 1 chain	Rattus norvegicus	57-63
28454878-5	2017	Knockdown of TS using small interfering RNA (siRNA) or inhibiting AKT activity with PI3K inhibitor LY294002 enhanced the cytotoxicity and cell growth inhibition of erlotinib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	AKT serine/threonine kinase 1	Homo sapiens	66-69
28458167-3	2017	In this study, we established a model of SIMD induced by lipopolysaccharide (LPS), subsequently used the selective inhibitor LY294002 and AS605240 to block the effect of PI3K and PI3K-gamma, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	179-189
28925480-12	2017	Over-expression of PTEN and/or LY294002 remarkably decreased protein expression in RMC, inhibited the effect of IL-6 on proliferation, and induced cell apoptosis and cycle arrest.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	interleukin 6	Rattus norvegicus	112-116
28075049-7	2017	Again, either the M90-SHIP plasmid or the PI3K/Akt pathway inhibitor LY294002 could significantly prevent the high glucose-induced increase in TGF-beta1, alpha-SMA, and secreted Col 3 and decreased E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	thymoma viral proto-oncogene 1	Mus musculus	47-50
28478514-5	2017	The phosphoinositide 3-kinase (PI3K) inhibitor LY294002 prevented this increase in p-Akt and reversed the inhibitory effects of salidroside on CD11b and inflammatory mediators.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	4-29
28478514-5	2017	The phosphoinositide 3-kinase (PI3K) inhibitor LY294002 prevented this increase in p-Akt and reversed the inhibitory effects of salidroside on CD11b and inflammatory mediators.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
28478514-5	2017	The phosphoinositide 3-kinase (PI3K) inhibitor LY294002 prevented this increase in p-Akt and reversed the inhibitory effects of salidroside on CD11b and inflammatory mediators.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	integrin subunit alpha M	Rattus norvegicus	143-148
28478514-7	2017	The stimulatory effects of salidroside on HIFalpha subunits were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	42-50
28075049-7	2017	Again, either the M90-SHIP plasmid or the PI3K/Akt pathway inhibitor LY294002 could significantly prevent the high glucose-induced increase in TGF-beta1, alpha-SMA, and secreted Col 3 and decreased E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	transforming growth factor, beta 1	Mus musculus	143-152
28401302-13	2017	In addition, the growth of U251 glioma xenografts treated with the combination of Ad-PTEN and LY294002 was significantly inhibited compared with those treated with Ad-PTEN or LY294002 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	phosphatase and tensin homolog	Homo sapiens	167-171
28075049-7	2017	Again, either the M90-SHIP plasmid or the PI3K/Akt pathway inhibitor LY294002 could significantly prevent the high glucose-induced increase in TGF-beta1, alpha-SMA, and secreted Col 3 and decreased E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	actin alpha 2, smooth muscle, aorta	Mus musculus	154-163
28401302-13	2017	In addition, the growth of U251 glioma xenografts treated with the combination of Ad-PTEN and LY294002 was significantly inhibited compared with those treated with Ad-PTEN or LY294002 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	phosphatase and tensin homolog	Homo sapiens	85-89
28371277-6	2017	Compared to the blank group, PI3K, Akt and eNOS were down-regulated in the miR-138 mimic and LY294002 groups but were up-regulated in the miR-138 inhibitor group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Homo sapiens	35-38
28371277-6	2017	Compared to the blank group, PI3K, Akt and eNOS were down-regulated in the miR-138 mimic and LY294002 groups but were up-regulated in the miR-138 inhibitor group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	nitric oxide synthase 3	Homo sapiens	43-47
28075049-7	2017	Again, either the M90-SHIP plasmid or the PI3K/Akt pathway inhibitor LY294002 could significantly prevent the high glucose-induced increase in TGF-beta1, alpha-SMA, and secreted Col 3 and decreased E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	cadherin 1	Mus musculus	198-208
28371277-7	2017	The miR-138 mimic and LY294002 groups showed decreased concentrations of TNF-alpha, IL-6, IL-8 and NO and reduced activities of LDH and eNOS, while opposite trends were observed in the miR-138 inhibitor group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	tumor necrosis factor	Homo sapiens	73-82
28371277-7	2017	The miR-138 mimic and LY294002 groups showed decreased concentrations of TNF-alpha, IL-6, IL-8 and NO and reduced activities of LDH and eNOS, while opposite trends were observed in the miR-138 inhibitor group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	interleukin 6	Homo sapiens	84-88
28732574-10	2017	Pretreatment with phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 nullified the induction of the thermogenic genes by AF in primary brown adipocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	18-47
28371277-7	2017	The miR-138 mimic and LY294002 groups showed decreased concentrations of TNF-alpha, IL-6, IL-8 and NO and reduced activities of LDH and eNOS, while opposite trends were observed in the miR-138 inhibitor group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
28371277-7	2017	The miR-138 mimic and LY294002 groups showed decreased concentrations of TNF-alpha, IL-6, IL-8 and NO and reduced activities of LDH and eNOS, while opposite trends were observed in the miR-138 inhibitor group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	nitric oxide synthase 3	Homo sapiens	136-140
28371277-8	2017	The concentrations of IL-4 and IL-10 increased in the miR-138 mimic and LY294002 groups but decreased in the miR-138 inhibitor group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	interleukin 4	Homo sapiens	22-26
28371277-8	2017	The concentrations of IL-4 and IL-10 increased in the miR-138 mimic and LY294002 groups but decreased in the miR-138 inhibitor group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	interleukin 10	Homo sapiens	31-36
28753056-8	2017	The anti-melanogenic effects of 70 kGy gamma-irradiated luteolin were attenuated by the treatment of two specific inhibitors (PD98059 and LY294002), and these results indicate that the anti-melanogenic effects were mediated by ERK and PI3K signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	mitogen-activated protein kinase 1	Mus musculus	227-230
28292218-8	2017	What"s more, Akt was phosphorylated at the eighth hour stimulated by high glucose medium, and LY294002 inhibited the expression of Arg-1 and CD206 by blocking the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	arginase, liver	Mus musculus	131-136
28292218-8	2017	What"s more, Akt was phosphorylated at the eighth hour stimulated by high glucose medium, and LY294002 inhibited the expression of Arg-1 and CD206 by blocking the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	mannose receptor, C type 1	Mus musculus	141-146
28292218-8	2017	What"s more, Akt was phosphorylated at the eighth hour stimulated by high glucose medium, and LY294002 inhibited the expression of Arg-1 and CD206 by blocking the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	thymoma viral proto-oncogene 1	Mus musculus	182-185
28425622-16	2017	The upregulation of FGF23 was specifically and significantly inhibited by PI3K inhibitor Ly294002, indicating upregulation of FGF23 through PI3K in Nf1-deficient osteocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	fibroblast growth factor 23	Homo sapiens	20-25
28425622-16	2017	The upregulation of FGF23 was specifically and significantly inhibited by PI3K inhibitor Ly294002, indicating upregulation of FGF23 through PI3K in Nf1-deficient osteocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	fibroblast growth factor 23	Homo sapiens	126-131
28425622-16	2017	The upregulation of FGF23 was specifically and significantly inhibited by PI3K inhibitor Ly294002, indicating upregulation of FGF23 through PI3K in Nf1-deficient osteocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	neurofibromin 1	Homo sapiens	148-151
28656233-7	2017	Additionally, resveratrol was identified to act synergistically with LY-294002, a phosphorylation inhibitor of AKT, but antagonistically with insulin-like growth factor-1, an agonist of AKT phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-78	AKT serine/threonine kinase 1	Homo sapiens	111-114
28656239-7	2017	The specific PI3K inhibitors, LY294002 and wortmannin, markedly inhibited the EPO-mediated increases in p-AKT (Ser473), p-FOXO1 (Ser256) and p-GSK-3beta (Ser9) in the PA-induced HepG2 cells (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	erythropoietin	Homo sapiens	78-81
28656239-7	2017	The specific PI3K inhibitors, LY294002 and wortmannin, markedly inhibited the EPO-mediated increases in p-AKT (Ser473), p-FOXO1 (Ser256) and p-GSK-3beta (Ser9) in the PA-induced HepG2 cells (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	106-109
28656239-7	2017	The specific PI3K inhibitors, LY294002 and wortmannin, markedly inhibited the EPO-mediated increases in p-AKT (Ser473), p-FOXO1 (Ser256) and p-GSK-3beta (Ser9) in the PA-induced HepG2 cells (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	forkhead box O1	Homo sapiens	122-127
28656239-7	2017	The specific PI3K inhibitors, LY294002 and wortmannin, markedly inhibited the EPO-mediated increases in p-AKT (Ser473), p-FOXO1 (Ser256) and p-GSK-3beta (Ser9) in the PA-induced HepG2 cells (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	glycogen synthase kinase 3 beta	Homo sapiens	143-152
28789432-6	2017	In addition, luteolin combined with LY294002 markedly increased the Bax/Bcl-2 ratio, while when combined with U0126, luteolin had less effects on the Bax/Bcl-2 ratio compared with luteolin treatment alone, suggesting that both the MAPK and PI3K signaling pathways are involved in the apoptosis induced by luteolin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	BCL2 associated X, apoptosis regulator	Homo sapiens	68-71
28627590-7	2017	Furthermore, the blockade of the PI3K/Akt signaling pathway by intranasal administration of LY294002, significantly reduced the SHH-associated neuroprotective effects on dopaminergic neurons, improved motor functions, and increased the microglial activation and inflammatory response in a mouse model of PD induced using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	thymoma viral proto-oncogene 1	Mus musculus	38-41
28627590-7	2017	Furthermore, the blockade of the PI3K/Akt signaling pathway by intranasal administration of LY294002, significantly reduced the SHH-associated neuroprotective effects on dopaminergic neurons, improved motor functions, and increased the microglial activation and inflammatory response in a mouse model of PD induced using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	sonic hedgehog	Mus musculus	128-131
28789432-6	2017	In addition, luteolin combined with LY294002 markedly increased the Bax/Bcl-2 ratio, while when combined with U0126, luteolin had less effects on the Bax/Bcl-2 ratio compared with luteolin treatment alone, suggesting that both the MAPK and PI3K signaling pathways are involved in the apoptosis induced by luteolin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	BCL2 apoptosis regulator	Homo sapiens	72-77
29256223-7	2017	The proportion of cells in G0/G1 phase increased and that in S phase declined in CXCR4-downregulated cell, and the effect was more significant when combined with the use of LY294002 or U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	C-X-C motif chemokine receptor 4	Homo sapiens	81-86
27121073-11	2017	Pretreatment with the phosphoinositide 3-kinase inhibitor LY294002 (20 mumol/L) significantly decreased clonogenic survival and enhanced apoptosis in gelsolin-overexpressing A549 and H460 cells after irradiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	gelsolin	Homo sapiens	150-158
28823274-6	2017	CONCLUSION: LY294002 can inhibit U266 cell proliferation via suppresion of activation of PI3K/AKT signal pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Homo sapiens	94-97
28775672-11	2017	Subsequently, a significantly decreased expression of p-AKT and Bcl-2, increased expression of Caspase-3 were observed in the LY294002 plus radiation group compared with radiation alone group, while these influences caused by LY294002 or X-ray radiation were reversed after COL1A1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	BCL2 apoptosis regulator	Homo sapiens	64-69
28775672-11	2017	Subsequently, a significantly decreased expression of p-AKT and Bcl-2, increased expression of Caspase-3 were observed in the LY294002 plus radiation group compared with radiation alone group, while these influences caused by LY294002 or X-ray radiation were reversed after COL1A1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	caspase 3	Homo sapiens	95-104
28775672-11	2017	Subsequently, a significantly decreased expression of p-AKT and Bcl-2, increased expression of Caspase-3 were observed in the LY294002 plus radiation group compared with radiation alone group, while these influences caused by LY294002 or X-ray radiation were reversed after COL1A1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	collagen type I alpha 1 chain	Homo sapiens	274-280
28716053-13	2017	Overexpression of the active Akt protein decreased ibrutinib-induced autophagy, while inhibiting Akt by LY294002 treatment enhanced ibrutinib-induced autophagy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	AKT serine/threonine kinase 1	Homo sapiens	97-100
29100311-8	2017	The PI3K inhibitor LY294002 inhibited HADH shRNA induced migration/invasion, and abolished the upregulation of p-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	hydroxyacyl-CoA dehydrogenase	Homo sapiens	38-42
28938602-9	2017	We further demonstrated that lapatinib-induced CIP2A downregulation can be recapitulated by LY294002, suggesting that Akt mediates CIP2A upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	cellular inhibitor of PP2A	Homo sapiens	47-52
28938602-9	2017	We further demonstrated that lapatinib-induced CIP2A downregulation can be recapitulated by LY294002, suggesting that Akt mediates CIP2A upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	118-121
28408345-8	2017	Interestingly, DKK1, an inhibitor of Wnt/beta-catenin signaling inhibitor, and LY294002, an inhibitor of PI3K/Akt signaling, abolished the induction of DEC1 by icariin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	thymoma viral proto-oncogene 1	Mus musculus	110-113
28408345-8	2017	Interestingly, DKK1, an inhibitor of Wnt/beta-catenin signaling inhibitor, and LY294002, an inhibitor of PI3K/Akt signaling, abolished the induction of DEC1 by icariin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	basic helix-loop-helix family, member e40	Mus musculus	152-156
28490422-8	2017	Furthermore, early- and late-phase responses to PTH were diminished by inhibitors of PI3K (wortmannin and LY-294002) and PKA (PKI 14-22).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-115	parathyroid hormone	Homo sapiens	48-51
28528862-13	2017	Importantly, preconditioning with antagonist of LY294002 (for PI3K/AKT) or NG-monomethyl-l-arginine (for eNOS) antagonized the beneficial effect of crocetin on diabetic EPC dysfunction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	thymoma viral proto-oncogene 1	Mus musculus	67-70
28545028-5	2017	Moreover, PI3K inhibitor LY294002, AKT-shRNA and IkappaBalpha-shRNA could decrease the protein content of phospho-P65 (Ser536), phospho-IkappaBalpha, phospho-AKT and phospho-IKKbeta while increasing the level of P65 compared to STC1 overexpression groups in cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	RELA proto-oncogene, NF-kB subunit	Homo sapiens	114-117
28545028-5	2017	Moreover, PI3K inhibitor LY294002, AKT-shRNA and IkappaBalpha-shRNA could decrease the protein content of phospho-P65 (Ser536), phospho-IkappaBalpha, phospho-AKT and phospho-IKKbeta while increasing the level of P65 compared to STC1 overexpression groups in cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	NFKB inhibitor alpha	Homo sapiens	136-148
28545028-5	2017	Moreover, PI3K inhibitor LY294002, AKT-shRNA and IkappaBalpha-shRNA could decrease the protein content of phospho-P65 (Ser536), phospho-IkappaBalpha, phospho-AKT and phospho-IKKbeta while increasing the level of P65 compared to STC1 overexpression groups in cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	158-161
28545028-5	2017	Moreover, PI3K inhibitor LY294002, AKT-shRNA and IkappaBalpha-shRNA could decrease the protein content of phospho-P65 (Ser536), phospho-IkappaBalpha, phospho-AKT and phospho-IKKbeta while increasing the level of P65 compared to STC1 overexpression groups in cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	174-181
28545028-5	2017	Moreover, PI3K inhibitor LY294002, AKT-shRNA and IkappaBalpha-shRNA could decrease the protein content of phospho-P65 (Ser536), phospho-IkappaBalpha, phospho-AKT and phospho-IKKbeta while increasing the level of P65 compared to STC1 overexpression groups in cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	RELA proto-oncogene, NF-kB subunit	Homo sapiens	212-215
28438649-12	2017	LY294002, a phosphoinositide-3-kinase/Akt inhibitor, inhibited the canstatin-induced proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	38-41
28549860-13	2017	Moreover, treatment with LY294002, a PI3K inhibitor, abrogated CS-TG (200mug/mL) induced down-regulation of cleaved caspase-3, Bax/Bcl-2 in the serum.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	caspase 3	Rattus norvegicus	116-125
28549860-13	2017	Moreover, treatment with LY294002, a PI3K inhibitor, abrogated CS-TG (200mug/mL) induced down-regulation of cleaved caspase-3, Bax/Bcl-2 in the serum.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	BCL2 associated X, apoptosis regulator	Rattus norvegicus	127-130
28549860-13	2017	Moreover, treatment with LY294002, a PI3K inhibitor, abrogated CS-TG (200mug/mL) induced down-regulation of cleaved caspase-3, Bax/Bcl-2 in the serum.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	BCL2, apoptosis regulator	Rattus norvegicus	131-136
28781955-3	2017	In ErbB2-overexpressing breast epithelial cells, miR-205 expression was significantly increased by treatment with MEK inhibitor U0126 or PD98059, Raf-1 inhibitor ZM-336372, and ERK inhibitor SCH772984, but PI3K inhibitor LY294002 and p38 MAPK inhibitor SB203580 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	221-229	erb-b2 receptor tyrosine kinase 2	Homo sapiens	3-8
28781955-3	2017	In ErbB2-overexpressing breast epithelial cells, miR-205 expression was significantly increased by treatment with MEK inhibitor U0126 or PD98059, Raf-1 inhibitor ZM-336372, and ERK inhibitor SCH772984, but PI3K inhibitor LY294002 and p38 MAPK inhibitor SB203580 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	221-229	microRNA 205	Homo sapiens	49-56
28385482-6	2017	Moreover, we demonstrated that the specific PI3K inhibitor LY294002 could reverse nicotine-induced cell migration and invasion, NF-kappaB activation and up-regulation of Vimentin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	nuclear factor kappa B subunit 1	Homo sapiens	128-137
28385482-6	2017	Moreover, we demonstrated that the specific PI3K inhibitor LY294002 could reverse nicotine-induced cell migration and invasion, NF-kappaB activation and up-regulation of Vimentin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	vimentin	Homo sapiens	170-178
28531921-8	2017	Co-treatment of the cardiomyocytes with the PI3K/Akt-specific inhibitor LY294002 blocked the HPT-induced cardioprotective effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Rattus norvegicus	49-52
28673004-9	2017	Furthermore, puerarin inhibited the TNF-alpha-induced decrease in the phosphorylation of Akt, which was abolished by LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, suggesting that the PI3K/Akt pathway participated in the suppressive effect of puerarin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Rattus norvegicus	89-92
27990618-7	2017	Naloxone, naltrindole hydrochloride, LY294002 and MK-2206 inhibited the LE-mediated attenuation of increased cleaved caspase-3 and caspase-8 expression induced by verapamil.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	caspase 8	Rattus norvegicus	131-140
28673004-9	2017	Furthermore, puerarin inhibited the TNF-alpha-induced decrease in the phosphorylation of Akt, which was abolished by LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, suggesting that the PI3K/Akt pathway participated in the suppressive effect of puerarin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	tumor necrosis factor	Rattus norvegicus	36-45
28673004-9	2017	Furthermore, puerarin inhibited the TNF-alpha-induced decrease in the phosphorylation of Akt, which was abolished by LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, suggesting that the PI3K/Akt pathway participated in the suppressive effect of puerarin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Rattus norvegicus	202-205
28407559-6	2017	Interestingly, COX-2 induction by PGE2 and beraprost, but not PGF2alpha, was enhanced by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
28281184-3	2017	First, we find that TGF-beta1 induces activation and extracellular matrix (ECM) formation in PSCs, and the effects are blocked by the inhibitor of PI3K (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	transforming growth factor beta 1	Homo sapiens	20-29
28693237-6	2017	Furthermore, the combination of certain pharmacological inhibitors, including phosphoinositide 3-kinase (PI3K; LY294002), ERK1/2 (U0126) and delphinidin significantly reduced the proliferation of SKOV3 cells and the phosphorylation of each of those target proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	78-103
28433890-9	2017	Moreover, treatment with an AKT agonist, insulin-like growth factor 1 (IGF-1), reversed these IL-37-mediated effects on autophagy, and treatment with an phosphoinositide-3-kinase (PI3K)/AKT inhibitor, LY294002, mimicked the effects of IL-37.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	insulin like growth factor 1	Homo sapiens	41-69
28433890-9	2017	Moreover, treatment with an AKT agonist, insulin-like growth factor 1 (IGF-1), reversed these IL-37-mediated effects on autophagy, and treatment with an phosphoinositide-3-kinase (PI3K)/AKT inhibitor, LY294002, mimicked the effects of IL-37.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	insulin like growth factor 1	Homo sapiens	71-76
28433890-9	2017	Moreover, treatment with an AKT agonist, insulin-like growth factor 1 (IGF-1), reversed these IL-37-mediated effects on autophagy, and treatment with an phosphoinositide-3-kinase (PI3K)/AKT inhibitor, LY294002, mimicked the effects of IL-37.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	interleukin 37	Homo sapiens	94-99
28433890-9	2017	Moreover, treatment with an AKT agonist, insulin-like growth factor 1 (IGF-1), reversed these IL-37-mediated effects on autophagy, and treatment with an phosphoinositide-3-kinase (PI3K)/AKT inhibitor, LY294002, mimicked the effects of IL-37.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	153-178
28671020-3	2017	In addition, we confirmed that the phosphoinositide 3-kinase/Akt and Wnt/beta-catenin signaling pathways were correlated with tumorigenesis, progression, and maintenance of gastric cancer using the phosphoinositide 3-kinase inhibitor LY294002 and an inhibitor of the beta-catenin/TCF4 complex, FH535.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	AKT serine/threonine kinase 1	Homo sapiens	61-64
28977927-12	2017	Treatment with PI3K inhibitor LY294002 and beta-catenin siRNA blocked the effects of TRIM22 on EMT in TRIM22-overexpressing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	tripartite motif containing 22	Homo sapiens	85-91
28977927-12	2017	Treatment with PI3K inhibitor LY294002 and beta-catenin siRNA blocked the effects of TRIM22 on EMT in TRIM22-overexpressing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	tripartite motif containing 22	Homo sapiens	102-108
28671020-3	2017	In addition, we confirmed that the phosphoinositide 3-kinase/Akt and Wnt/beta-catenin signaling pathways were correlated with tumorigenesis, progression, and maintenance of gastric cancer using the phosphoinositide 3-kinase inhibitor LY294002 and an inhibitor of the beta-catenin/TCF4 complex, FH535.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	catenin beta 1	Homo sapiens	73-85
28968999-9	2017	Furthermore, the association between Akt and mTOR can be regulated by serum, insulin and LY294002, but not by rapamycin or MAPK kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	AKT serine/threonine kinase 1	Homo sapiens	37-40
28968999-9	2017	Furthermore, the association between Akt and mTOR can be regulated by serum, insulin and LY294002, but not by rapamycin or MAPK kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	mechanistic target of rapamycin kinase	Homo sapiens	45-49
28592228-8	2017	LY294002 (Akt inhibitor) was used to examine whether Akt phosphorylation was a downstream mechanism of TGF-beta1 induced expression of procollagen1A1, fibronectin, and alpha-smooth muscle actin in HIFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	10-13
28654704-8	2017	It was also found that NGF supplement repressed the induced apoptosis, and increased p-Akt and p-Bad level in 2,5-HD treated VSC4.1 cells, which could be antagonized by PI3K kinase (the upstream member of Akt) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	nerve growth factor	Rattus norvegicus	23-26
28654704-8	2017	It was also found that NGF supplement repressed the induced apoptosis, and increased p-Akt and p-Bad level in 2,5-HD treated VSC4.1 cells, which could be antagonized by PI3K kinase (the upstream member of Akt) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	AKT serine/threonine kinase 1	Rattus norvegicus	205-208
28646880-10	2017	The inhibitors of Trk receptor (K252a), MEK/ERK1/2 (U0126 and PD98059) and PI3K/AKT (LY294002) attenuated the neuritogenic activity of both NGF and 6-shogaol, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Rattus norvegicus	80-83
28479244-7	2017	However, the level of insulin mRNA in TGX-221-treated cells was significantly higher than that in LY294002-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	insulin	Homo sapiens	22-29
28598994-7	2017	The ATR oil/asarone-induced gene expression could be mediated by Akt phosphorylation; because the applied LY294002, a phosphoinositide 3-kinase inhibitor, fully abolished the induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
28592228-8	2017	LY294002 (Akt inhibitor) was used to examine whether Akt phosphorylation was a downstream mechanism of TGF-beta1 induced expression of procollagen1A1, fibronectin, and alpha-smooth muscle actin in HIFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transforming growth factor beta 1	Homo sapiens	103-112
28584284-6	2017	Additionally, LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, abolished the protective effects of EPO in HG-treated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	26-55
28584284-6	2017	Additionally, LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, abolished the protective effects of EPO in HG-treated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	erythropoietin	Rattus norvegicus	110-113
28365917-12	2017	HBSP activated the PI3K/Akt/mTORC1 pathway, which was confirmed by the PI3K inhibitor LY294002 both in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	thymoma viral proto-oncogene 1	Mus musculus	24-27
28386751-11	2017	This anti-apoptotic effect of RLX was attenuated by co-administration of the Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	AKT serine/threonine kinase 1	Homo sapiens	77-80
28365917-12	2017	HBSP activated the PI3K/Akt/mTORC1 pathway, which was confirmed by the PI3K inhibitor LY294002 both in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	CREB regulated transcription coactivator 1	Mus musculus	28-34
28273403-9	2017	Meanwhile we treated BMDMs from emphysematous mice and CSE-treated RAW264.7 cells with the phosphoinositide 3-kinase (PI3K)/Akt inhibitor (LY294002), we observed a reduction in RNA levels of M2 macrophage-related markers and cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	91-116
28412208-10	2017	Consequently, we revealed that BzATP accelerated the proliferation of CRC cells, whereas co-incubation with PI3K/Akt inhibitor LY294002 significantly impaired BzATP-induced proliferation of CRC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	113-116
28537766-9	2017	The expression of CDK2, CDK6, cyclin D1, and cyclin D3 were inhibited by LY294002, U0126, and SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	cyclin dependent kinase 2	Homo sapiens	18-22
28537766-9	2017	The expression of CDK2, CDK6, cyclin D1, and cyclin D3 were inhibited by LY294002, U0126, and SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	cyclin dependent kinase 6	Homo sapiens	24-28
28537766-9	2017	The expression of CDK2, CDK6, cyclin D1, and cyclin D3 were inhibited by LY294002, U0126, and SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	cyclin D1	Homo sapiens	30-39
28537766-9	2017	The expression of CDK2, CDK6, cyclin D1, and cyclin D3 were inhibited by LY294002, U0126, and SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	cyclin D3	Homo sapiens	45-54
28365254-5	2017	Moreover, arecoline-induced HIF-1alpha expression was downregulated by mitogen-activated protein kinase inhibitor U0126, phosphatidylinositol 3-kinase inhibitor LY294002, p38 inhibitor SB203580, cyclooxygenase-2 inhibitor NS-398, and glutathione precursor N-acetyl-L-cysteine (p&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
27808000-10	2017	The effects were abolished by using pharmacological inhibition of PI3K/Akt with LY294002 and paralleled by transfecting DCs with klotho siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	thymoma viral proto-oncogene 1	Mus musculus	71-74
28417539-10	2017	Inhibition of the AKT pathway by its specific inhibitor LY294002 resulted in downregulation of MRP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	18-21
28417539-10	2017	Inhibition of the AKT pathway by its specific inhibitor LY294002 resulted in downregulation of MRP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	ATP binding cassette subfamily C member 1	Homo sapiens	95-99
28273403-9	2017	Meanwhile we treated BMDMs from emphysematous mice and CSE-treated RAW264.7 cells with the phosphoinositide 3-kinase (PI3K)/Akt inhibitor (LY294002), we observed a reduction in RNA levels of M2 macrophage-related markers and cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	thymoma viral proto-oncogene 1	Mus musculus	124-127
28639894-7	2017	Moreover, phosphoinositide 3-kinase/AKT pathway inhibitor LY294002 and Janus kinase/signal transducer and activator of transcription pathway inhibitor AG490 could downregulate cell division cycle protein 6 expression in K562 cells, but not RAS/mitogen-activated protein kinase pathway inhibitor PD98059 had such effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Homo sapiens	36-39
28344073-7	2017	The thrombin-induced MMP-9 release was inhibited by U0126, LY294002, Go6976, and Go6983.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	coagulation factor II, thrombin	Homo sapiens	4-12
28342896-8	2017	The p-Akt and p-GSK3beta upregulation by TBN was abolished by a specific phosphoinositide 3-kinase (PI3K) inhibitor LY294002, resulting in suppression of axonal outgrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Rattus norvegicus	4-9
28342896-8	2017	The p-Akt and p-GSK3beta upregulation by TBN was abolished by a specific phosphoinositide 3-kinase (PI3K) inhibitor LY294002, resulting in suppression of axonal outgrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	glycogen synthase kinase 3 beta	Rattus norvegicus	16-24
28342896-8	2017	The p-Akt and p-GSK3beta upregulation by TBN was abolished by a specific phosphoinositide 3-kinase (PI3K) inhibitor LY294002, resulting in suppression of axonal outgrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	TATA-box binding protein associated factor 8	Rattus norvegicus	41-44
28915637-7	2017	Further mechanism study revealed that BTK activated AKT signaling leading to down-regulation of P27 expression and hindered RB activity while AKT inhibitor, LY294002, overcame BTK-overexpression induced cellular senescence resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	AKT serine/threonine kinase 1	Homo sapiens	142-145
28915637-7	2017	Further mechanism study revealed that BTK activated AKT signaling leading to down-regulation of P27 expression and hindered RB activity while AKT inhibitor, LY294002, overcame BTK-overexpression induced cellular senescence resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	Bruton tyrosine kinase	Homo sapiens	176-179
28524116-9	2017	Pretreatment with LY294002, an autophagy and PI3K inhibitor, enhanced the salinomycin-induced apoptosis by decreasing the AKT and mTOR activities and suppressing autophagy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	122-125
28524116-9	2017	Pretreatment with LY294002, an autophagy and PI3K inhibitor, enhanced the salinomycin-induced apoptosis by decreasing the AKT and mTOR activities and suppressing autophagy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	mechanistic target of rapamycin kinase	Homo sapiens	130-134
28478808-14	2017	In addition, 10muM LY294002 (a specific inhibitor of PI3K/Akt) combination with 40muM harmine significantly increased the cytotoxicity to the gastric cancer cells and up-regulated both the apoptosis-related protein (cleaved-PARP, cleaved-caspase-3) and autophagy-related protein (Beclin-1, LC3-II, and p62).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	58-61
28478808-14	2017	In addition, 10muM LY294002 (a specific inhibitor of PI3K/Akt) combination with 40muM harmine significantly increased the cytotoxicity to the gastric cancer cells and up-regulated both the apoptosis-related protein (cleaved-PARP, cleaved-caspase-3) and autophagy-related protein (Beclin-1, LC3-II, and p62).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	collagen type XI alpha 2 chain	Homo sapiens	224-228
28478808-14	2017	In addition, 10muM LY294002 (a specific inhibitor of PI3K/Akt) combination with 40muM harmine significantly increased the cytotoxicity to the gastric cancer cells and up-regulated both the apoptosis-related protein (cleaved-PARP, cleaved-caspase-3) and autophagy-related protein (Beclin-1, LC3-II, and p62).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	beclin 1	Homo sapiens	280-288
28344073-7	2017	The thrombin-induced MMP-9 release was inhibited by U0126, LY294002, Go6976, and Go6983.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	matrix metallopeptidase 9	Homo sapiens	21-26
28343995-8	2017	The protection of UA was abolished by LY294002, a PI3K/Akt-inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	thymoma viral proto-oncogene 1	Mus musculus	55-58
28478808-14	2017	In addition, 10muM LY294002 (a specific inhibitor of PI3K/Akt) combination with 40muM harmine significantly increased the cytotoxicity to the gastric cancer cells and up-regulated both the apoptosis-related protein (cleaved-PARP, cleaved-caspase-3) and autophagy-related protein (Beclin-1, LC3-II, and p62).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	nucleoporin 62	Homo sapiens	302-305
28881663-5	2017	Inhibitors of mitogen-activated protein kinase (MAPK) U0126 and phosphatidylinositol-3-kinases (PI3K) LY294002 reversed the protein levels of integrin-beta1 and MMP-9 as well as the migratory ability induced by BPA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	integrin beta 1 (fibronectin receptor beta)	Mus musculus	142-156
28881663-5	2017	Inhibitors of mitogen-activated protein kinase (MAPK) U0126 and phosphatidylinositol-3-kinases (PI3K) LY294002 reversed the protein levels of integrin-beta1 and MMP-9 as well as the migratory ability induced by BPA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	matrix metallopeptidase 9	Mus musculus	161-166
28302560-8	2017	Furthermore, LY294002, an Akt inhibitor, significantly attenuated TCDD-triggered HSC activation through blocking Akt phosphorylation and NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	thymoma viral proto-oncogene 1	Mus musculus	26-29
28302560-8	2017	Furthermore, LY294002, an Akt inhibitor, significantly attenuated TCDD-triggered HSC activation through blocking Akt phosphorylation and NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	thymoma viral proto-oncogene 1	Mus musculus	113-116
28302560-8	2017	Furthermore, LY294002, an Akt inhibitor, significantly attenuated TCDD-triggered HSC activation through blocking Akt phosphorylation and NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	137-146
29029396-9	2017	Moreover, the administration of AM630, LY294002, U0126 and AG490 (inhibitors for CB2, Akt, ERK1/2 and Stat3, respectively) could abolish the beneficial actions of AM1241.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	cannabinoid receptor 2 (macrophage)	Mus musculus	81-84
29029396-9	2017	Moreover, the administration of AM630, LY294002, U0126 and AG490 (inhibitors for CB2, Akt, ERK1/2 and Stat3, respectively) could abolish the beneficial actions of AM1241.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	thymoma viral proto-oncogene 1	Mus musculus	86-89
29029396-9	2017	Moreover, the administration of AM630, LY294002, U0126 and AG490 (inhibitors for CB2, Akt, ERK1/2 and Stat3, respectively) could abolish the beneficial actions of AM1241.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	mitogen-activated protein kinase 3	Mus musculus	91-97
29029396-9	2017	Moreover, the administration of AM630, LY294002, U0126 and AG490 (inhibitors for CB2, Akt, ERK1/2 and Stat3, respectively) could abolish the beneficial actions of AM1241.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	signal transducer and activator of transcription 3	Mus musculus	102-107
28193579-8	2017	Inhibition of PI3K signaling by LY294002 counteracted zinc promotion, as shown by a decrease in AP activity, TEER, the abundance of ZO-1 and phosphorylation of AKT and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	tight junction protein 1	Homo sapiens	132-136
28591364-1	2017	Purpose: : To investigate the mechanisms by which PD98059 and LY294002 interfere with the abnormal deposition of extracellular matrix regulated by connective tissue growth factor (CTGF) of rat pulmonary artery smooth muscle cells (PASMCs).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	cellular communication network factor 2	Rattus norvegicus	147-178
28591364-1	2017	Purpose: : To investigate the mechanisms by which PD98059 and LY294002 interfere with the abnormal deposition of extracellular matrix regulated by connective tissue growth factor (CTGF) of rat pulmonary artery smooth muscle cells (PASMCs).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	cellular communication network factor 2	Rattus norvegicus	180-184
28591364-9	2017	PD98059 and LY294002 can inhibit the ERK1/2 and PI3K/PKB signaling pathways, respectively, thus interfering with the biological effects of CTGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	mitogen activated protein kinase 3	Rattus norvegicus	37-43
28591364-9	2017	PD98059 and LY294002 can inhibit the ERK1/2 and PI3K/PKB signaling pathways, respectively, thus interfering with the biological effects of CTGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	cellular communication network factor 2	Rattus norvegicus	139-143
27579673-8	2017	Conditional medium from GREM1-MSCs (GREM1-MSC-CM) increased the anti-apoptotic effects of human umbilical vein endothelial cells (HUVECs), and this effect was attenuated by treatment with the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	gremlin 1, DAN family BMP antagonist	Homo sapiens	24-29
27579673-8	2017	Conditional medium from GREM1-MSCs (GREM1-MSC-CM) increased the anti-apoptotic effects of human umbilical vein endothelial cells (HUVECs), and this effect was attenuated by treatment with the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	gremlin 1, DAN family BMP antagonist	Homo sapiens	36-41
28250059-9	2017	More intriguingly, preconditioning with LY294002 (PI3K/AKT antagonist) or NG-monomethyl-l-arginine (eNOS inhibitor) antagonized netrin-1-induced activation of the PI3K/AKT-eNOS pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	55-58
28250059-9	2017	More intriguingly, preconditioning with LY294002 (PI3K/AKT antagonist) or NG-monomethyl-l-arginine (eNOS inhibitor) antagonized netrin-1-induced activation of the PI3K/AKT-eNOS pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	netrin 1	Homo sapiens	128-136
28250059-9	2017	More intriguingly, preconditioning with LY294002 (PI3K/AKT antagonist) or NG-monomethyl-l-arginine (eNOS inhibitor) antagonized netrin-1-induced activation of the PI3K/AKT-eNOS pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	168-171
28238830-6	2017	In half of each group LY294002, which is a PI3K/Akt inhibitor, was applied on the ischemic cortex immediately after MCA occlusion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Rattus norvegicus	48-51
27488855-11	2017	Whereas, all of the aforementioned effects of ATV were reversed by LY294002 (an inhibitor of Akt1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Rattus norvegicus	93-97
28181145-11	2017	LY294002 suppressed p-Akt, activated autophagy, and decreased connexin43 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
28181145-11	2017	LY294002 suppressed p-Akt, activated autophagy, and decreased connexin43 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	gap junction protein, alpha 1	Rattus norvegicus	62-72
28229220-9	2017	We found that the combined treatment of HepaCAM-overexpressing adenovirus with the PI3K inhibitor LY294002 enhanced the inhibitory effects on cell proliferation, viability and protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	hepatic and glial cell adhesion molecule	Homo sapiens	40-47
28193579-8	2017	Inhibition of PI3K signaling by LY294002 counteracted zinc promotion, as shown by a decrease in AP activity, TEER, the abundance of ZO-1 and phosphorylation of AKT and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	160-163
28193579-8	2017	Inhibition of PI3K signaling by LY294002 counteracted zinc promotion, as shown by a decrease in AP activity, TEER, the abundance of ZO-1 and phosphorylation of AKT and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	mechanistic target of rapamycin kinase	Homo sapiens	168-172
28461772-3	2017	Up-regulation of mDC-specific markers like CD80, CD83 and CD88 induced by stimulation with 27OHChol was significantly reduced in the presence of LY294002, an inhibitor of PI3K, and U0126, an inhibitor of ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	CD80 molecule	Homo sapiens	43-47
28218740-8	2017	Finally, the lipoxin A4 Receptor inhibitor (BOC-2) and PI3K inhibitor (LY294002) not only blocked MaR1"s effects on cAMP/cGMP, the expression of phosphorylated Akt and Nedd4-2, but also inhibited the effect of MaR1 on AFC in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Rattus norvegicus	160-163
28218740-8	2017	Finally, the lipoxin A4 Receptor inhibitor (BOC-2) and PI3K inhibitor (LY294002) not only blocked MaR1"s effects on cAMP/cGMP, the expression of phosphorylated Akt and Nedd4-2, but also inhibited the effect of MaR1 on AFC in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	NEDD4 like E3 ubiquitin protein ligase	Rattus norvegicus	168-175
28461772-3	2017	Up-regulation of mDC-specific markers like CD80, CD83 and CD88 induced by stimulation with 27OHChol was significantly reduced in the presence of LY294002, an inhibitor of PI3K, and U0126, an inhibitor of ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	CD83 molecule	Homo sapiens	49-53
28461772-3	2017	Up-regulation of mDC-specific markers like CD80, CD83 and CD88 induced by stimulation with 27OHChol was significantly reduced in the presence of LY294002, an inhibitor of PI3K, and U0126, an inhibitor of ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	complement C5a receptor 1	Homo sapiens	58-62
28461772-3	2017	Up-regulation of mDC-specific markers like CD80, CD83 and CD88 induced by stimulation with 27OHChol was significantly reduced in the presence of LY294002, an inhibitor of PI3K, and U0126, an inhibitor of ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	mitogen-activated protein kinase 1	Homo sapiens	204-207
28461772-7	2017	Transcription and surface expression of CD molecules involved in atherosclerosis such as CD105, CD137 and CD166 were also significantly decreased by treatment with LY294002 and U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	TNF receptor superfamily member 9	Homo sapiens	96-101
28461772-7	2017	Transcription and surface expression of CD molecules involved in atherosclerosis such as CD105, CD137 and CD166 were also significantly decreased by treatment with LY294002 and U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	activated leukocyte cell adhesion molecule	Homo sapiens	106-111
28210955-9	2017	The effects of IGF-1 were abrogated by phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	insulin-like growth factor 1	Rattus norvegicus	15-20
27011380-6	2017	Intraplantar coinjection of ERK inhibitor, U0126, and PI3K inhibitor, LY294002, as well as two protein translation inhibitors, temsirolimus and cordycepin, prevented the development of SDF1-induced acute mechanical hyperalgesia and hyperalgesic priming.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	C-X-C motif chemokine ligand 12	Homo sapiens	185-189
28210955-9	2017	The effects of IGF-1 were abrogated by phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	39-68
28521450-6	2017	Further investigation revealed that phosphorylation of RAC-alpha serine/threonine-protein kinase (AKT) increased in response to PM2.5 exposure in HCC cells, and the AKT antagonist LY294002 reduced PM2.5-induced migration, invasion and MMP-13 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	AKT serine/threonine kinase 1	Homo sapiens	165-168
28247332-10	2017	In contrast, application of LY294002 or triciribine reversed the roles of GDNF in PD models.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	glial cell derived neurotrophic factor	Rattus norvegicus	74-78
28440481-3	2017	In the present study, the effect of matrine and LY294002 on the expression of the Akt/FoxO3a signaling pathway was examined by western blot analyses and RT-PCR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	82-85
28396512-7	2017	We used the PI3K inhibitor LY294002 and the siRNA si-Sp1 to suppress the activity of the PI3K/Akt/Sp1 signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	94-97
28440481-3	2017	In the present study, the effect of matrine and LY294002 on the expression of the Akt/FoxO3a signaling pathway was examined by western blot analyses and RT-PCR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	forkhead box O3	Homo sapiens	86-92
26993294-2	2017	It is demonstrated that LY294002, a small molecule inhibitor of phosphatidylinositol 3-kinase (PI3K)/Akt signal pathway, can inhibit proliferation and promote neuronal differentiation of mesenchymal stem cells (MSCs).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	101-104
26993294-8	2017	In conclusion, PCL/collagen electrospun scaffolds with Ly294002 have potential for being used in neural tissue engineering because of its bioactive and three-dimensional structure which enhances viability and differentiation of hEnSCs into neurons through inhibition of the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	279-282
28460455-7	2017	Cell proliferation promoted by CCDC106 via Cyclin A2 and Cyclin B1 was rescued by treatment with the AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	coiled-coil domain containing 106	Homo sapiens	31-38
28439402-7	2017	Further, LY294002, an inhibitor of PI3K, partially reversed the effect of curcumin on HO-1 protein induction, leading to the attenuation of curcumin-mediated apoptosis resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	heme oxygenase 1	Rattus norvegicus	86-90
27819673-8	2017	In turn, inhibition of PI3K kinase activity by the PI3K-speicfic inhibitor LY294002 impairs Src activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	92-95
28460455-7	2017	Cell proliferation promoted by CCDC106 via Cyclin A2 and Cyclin B1 was rescued by treatment with the AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	cyclin A2	Homo sapiens	43-52
28460455-7	2017	Cell proliferation promoted by CCDC106 via Cyclin A2 and Cyclin B1 was rescued by treatment with the AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	cyclin B1	Homo sapiens	57-66
28460455-7	2017	Cell proliferation promoted by CCDC106 via Cyclin A2 and Cyclin B1 was rescued by treatment with the AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	101-104
28191670-5	2017	Pretreatment of the cells with LY294002, a PI3K-specific inhibitor, suppressed not only BMP-9-enhanced alkaline phosphatase activity but also expression of a BMP-response gene (inhibitor of DNA binding 1) and osteogenic marker genes (runt-related transcription factor 2, osterix, bone sialoprotein, and osteopontin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	growth differentiation factor 2	Homo sapiens	88-93
28104444-7	2017	We also found that pretreatment with inhibitors of PI3K/AKT (LY294002), JAK/STAT (AG490) and NF-kB (BAY 11-7082) significantly reduced leptin-induced upA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Homo sapiens	56-59
28188779-9	2017	In the presence of LY294002 or ZM241385, the protective effects of HCH were markedly attenuated, but the effects of ZM241385 were reversed by bpv(HOpic).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	dedicator of cyto-kinesis 2	Mus musculus	67-70
28442995-7	2017	Inhibition of AKT activity with the PI3-K inhibitor LY294002 could downregulate AKT and PTEN phosphorylation and suppress axon outgrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	14-17
28442995-7	2017	Inhibition of AKT activity with the PI3-K inhibitor LY294002 could downregulate AKT and PTEN phosphorylation and suppress axon outgrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	80-83
28442995-7	2017	Inhibition of AKT activity with the PI3-K inhibitor LY294002 could downregulate AKT and PTEN phosphorylation and suppress axon outgrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	phosphatase and tensin homolog	Homo sapiens	88-92
28383489-6	2017	An examination of the PI3K/Akt upstream pathway revealed that UF-pretreated cells showed a decreased relative density of Akt, PI3K, and TrkA, and increased the phosphorylation of Akt, PI3K, and NGF; the PI3K inhibitor, LY294002, partially prevented this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	AKT serine/threonine kinase 1	Homo sapiens	27-30
28122716-12	2017	Pretreatment with LY294002 or MK-2206, to inhibit the phosphatidylinositol 3-kinase-Akt/protein kinase B cell survival pathway, significantly blunted the cytoprotective effect of relaxin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	84-87
28122716-12	2017	Pretreatment with LY294002 or MK-2206, to inhibit the phosphatidylinositol 3-kinase-Akt/protein kinase B cell survival pathway, significantly blunted the cytoprotective effect of relaxin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	protein tyrosine kinase 2 beta	Homo sapiens	88-104
28103512-6	2017	PoFUT1 increased the phosphorylation of ERK1/2, p38 MAPK, and PI3K/Akt, while inhibitors of ERK1/2(PD98059), p38 MAPK(SB203580), and PI3K (LY294002) prevented ERK1/2, p38 MAPK, and Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	protein O-fucosyltransferase 1	Homo sapiens	0-6
28103512-6	2017	PoFUT1 increased the phosphorylation of ERK1/2, p38 MAPK, and PI3K/Akt, while inhibitors of ERK1/2(PD98059), p38 MAPK(SB203580), and PI3K (LY294002) prevented ERK1/2, p38 MAPK, and Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	mitogen-activated protein kinase 3	Homo sapiens	40-46
27473470-11	2017	LY294002, a PI3K/Akt pathway inhibitor, led to increased autophagy and apoptosis in U251 RLIP76-depleted cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	17-20
27473470-11	2017	LY294002, a PI3K/Akt pathway inhibitor, led to increased autophagy and apoptosis in U251 RLIP76-depleted cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ralA binding protein 1	Homo sapiens	89-95
28191670-5	2017	Pretreatment of the cells with LY294002, a PI3K-specific inhibitor, suppressed not only BMP-9-enhanced alkaline phosphatase activity but also expression of a BMP-response gene (inhibitor of DNA binding 1) and osteogenic marker genes (runt-related transcription factor 2, osterix, bone sialoprotein, and osteopontin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	RUNX family transcription factor 2	Homo sapiens	234-269
28191670-5	2017	Pretreatment of the cells with LY294002, a PI3K-specific inhibitor, suppressed not only BMP-9-enhanced alkaline phosphatase activity but also expression of a BMP-response gene (inhibitor of DNA binding 1) and osteogenic marker genes (runt-related transcription factor 2, osterix, bone sialoprotein, and osteopontin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	Sp7 transcription factor	Homo sapiens	271-278
28191670-5	2017	Pretreatment of the cells with LY294002, a PI3K-specific inhibitor, suppressed not only BMP-9-enhanced alkaline phosphatase activity but also expression of a BMP-response gene (inhibitor of DNA binding 1) and osteogenic marker genes (runt-related transcription factor 2, osterix, bone sialoprotein, and osteopontin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	secreted phosphoprotein 1	Homo sapiens	303-314
28485797-7	2017	The enhanced migration can be blocked by the CXCR4 antagonist AMD3100 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, whereas mitogen-activated protein ERK1/2 kinase inhibitor PD98056 had no significant effect on enhanced migration induced by hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	78-107
28191670-6	2017	In addition, BMP-9 up-regulated SDF-1 production, and the production of SDF-1 was suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	growth differentiation factor 2	Homo sapiens	13-18
28191670-6	2017	In addition, BMP-9 up-regulated SDF-1 production, and the production of SDF-1 was suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	C-X-C motif chemokine ligand 12	Homo sapiens	72-77
28204829-6	2017	Importantly, treatment of the cells with GA or LY294002 (an inhibitor of Akt) prior to exposure to NaHS and HG considerably blocked the cardioprotective effects of NaHS against the HG-induced injury mentioned above.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Rattus norvegicus	73-76
27943011-8	2017	In contrast, the phosphorylated Akt concentration in macrophages treated with endotoxin plus vasopressin was significantly higher than that in macrophages treated with endotoxin or in macrophages treated with endotoxin plus vasopressin plus LY294002, TGX-221, IC-87114, or AS-252424, but not PIK-75.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	241-249	thymoma viral proto-oncogene 1	Mus musculus	32-35
28238066-10	2017	Moreover, using the PI3K/Akt inhibitor LY294002, we revealed that PI3K/Akt signaling plays a significant role in blocking oxidative stress, suppressing the pro-inflammatory response, and maintaining the neuroprotective effects of crocin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	thymoma viral proto-oncogene 1	Mus musculus	25-28
28197636-7	2017	Inhibitors of the PI3K-Akt and ERK1/2 pathways, LY294002 and U0126, significantly suppressed the EMT phenotype.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	23-26
28197636-7	2017	Inhibitors of the PI3K-Akt and ERK1/2 pathways, LY294002 and U0126, significantly suppressed the EMT phenotype.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	mitogen-activated protein kinase 3	Homo sapiens	31-37
28238066-10	2017	Moreover, using the PI3K/Akt inhibitor LY294002, we revealed that PI3K/Akt signaling plays a significant role in blocking oxidative stress, suppressing the pro-inflammatory response, and maintaining the neuroprotective effects of crocin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	thymoma viral proto-oncogene 1	Mus musculus	71-74
28260056-11	2017	Furthermore, IGF-1R is related with PI3K/Akt/mTOR signaling pathway and enhanced autophagy-associated protein expression, which was verified following treatment with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	insulin like growth factor 1 receptor	Homo sapiens	13-19
28614771-10	2017	Similarly, wortmannin and LY-294002, an inhibitors of the phosphatidylinositol 3-kinase (PI3K), an upstream signaling molecule of eNOS, attenuated the AMO-induced vasorelaxation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-35	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	58-87
28614771-10	2017	Similarly, wortmannin and LY-294002, an inhibitors of the phosphatidylinositol 3-kinase (PI3K), an upstream signaling molecule of eNOS, attenuated the AMO-induced vasorelaxation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-35	nitric oxide synthase 3	Rattus norvegicus	130-134
27400655-6	2017	Moreover, PD 98059, LY294002 and Bay 117082, which respectively inhibited the histamine and 4-methylhistamine induced phosphorylation of ERK1/2, Akt and NFkappaB-p65 respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mitogen-activated protein kinase 3	Homo sapiens	137-143
27400655-6	2017	Moreover, PD 98059, LY294002 and Bay 117082, which respectively inhibited the histamine and 4-methylhistamine induced phosphorylation of ERK1/2, Akt and NFkappaB-p65 respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	145-148
27400655-6	2017	Moreover, PD 98059, LY294002 and Bay 117082, which respectively inhibited the histamine and 4-methylhistamine induced phosphorylation of ERK1/2, Akt and NFkappaB-p65 respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	RELA proto-oncogene, NF-kB subunit	Homo sapiens	153-165
27400655-9	2017	In contrast, PI3 kinase inhibitor LY294002 had no effect on 4-MH induced RANTES/CCL5 production but blocked IL-13 generation by 117.58 pg/ml.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	interleukin 13	Homo sapiens	108-113
28260056-11	2017	Furthermore, IGF-1R is related with PI3K/Akt/mTOR signaling pathway and enhanced autophagy-associated protein expression, which was verified following treatment with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	AKT serine/threonine kinase 1	Homo sapiens	41-44
28260056-11	2017	Furthermore, IGF-1R is related with PI3K/Akt/mTOR signaling pathway and enhanced autophagy-associated protein expression, which was verified following treatment with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	mechanistic target of rapamycin kinase	Homo sapiens	45-49
28110104-8	2017	PI3K/Akt inhibitor LY294002 reversed Q3GA-induced Akt phosphorylation and cyclin D1 expression, thereby reducing Q3GA-induced proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	5-8
28110104-8	2017	PI3K/Akt inhibitor LY294002 reversed Q3GA-induced Akt phosphorylation and cyclin D1 expression, thereby reducing Q3GA-induced proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	50-53
28454373-10	2017	In addition, inhibition of the Akt signaling pathway using the Akt inhibitor LY294002 restored CYFIP2-knockdown SGC7901 cell chemosensitivity to 5-FU.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	31-34
28110104-8	2017	PI3K/Akt inhibitor LY294002 reversed Q3GA-induced Akt phosphorylation and cyclin D1 expression, thereby reducing Q3GA-induced proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	cyclin D1	Mus musculus	74-83
28454373-10	2017	In addition, inhibition of the Akt signaling pathway using the Akt inhibitor LY294002 restored CYFIP2-knockdown SGC7901 cell chemosensitivity to 5-FU.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	63-66
28454373-10	2017	In addition, inhibition of the Akt signaling pathway using the Akt inhibitor LY294002 restored CYFIP2-knockdown SGC7901 cell chemosensitivity to 5-FU.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	cytoplasmic FMR1 interacting protein 2	Homo sapiens	95-101
27590258-10	2017	In addition, the antiapoptotic effect of PCr enhanced p-Akt/Akt protein ratio, NO synthase (eNOS) activation, NO production and cGMP levels and also was partially suppressed by a PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	AKT serine/threonine kinase 1	Homo sapiens	56-59
27814668-12	2017	Orexin 1 receptor antagonist (SB3344867), PKC, and PI3-kinase (PI3K) inhibitors (chelerythrin and LY294002, respectively) could suppress the orexin-A neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	51-61
27590258-10	2017	In addition, the antiapoptotic effect of PCr enhanced p-Akt/Akt protein ratio, NO synthase (eNOS) activation, NO production and cGMP levels and also was partially suppressed by a PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	AKT serine/threonine kinase 1	Homo sapiens	60-63
28381172-9	2017	Furthermore, PI3K/AKT pathway and SOX2 were found necessary to maintain the stemness of CD147+ BCSCs by using LY294002 or lentiviral-si-SOX2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Homo sapiens	18-21
27590258-10	2017	In addition, the antiapoptotic effect of PCr enhanced p-Akt/Akt protein ratio, NO synthase (eNOS) activation, NO production and cGMP levels and also was partially suppressed by a PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	nitric oxide synthase 3	Homo sapiens	92-96
28381172-9	2017	Furthermore, PI3K/AKT pathway and SOX2 were found necessary to maintain the stemness of CD147+ BCSCs by using LY294002 or lentiviral-si-SOX2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	SRY-box transcription factor 2	Homo sapiens	34-38
28386321-8	2017	However, the PI3K/Akt inhibitor LY294002 reversed the protective effects of aFGF on neurofunctional deficits and junction protein expression and significantly suppressed p-Akt and GTP-Rac1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	18-21
28381172-9	2017	Furthermore, PI3K/AKT pathway and SOX2 were found necessary to maintain the stemness of CD147+ BCSCs by using LY294002 or lentiviral-si-SOX2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	basigin (Ok blood group)	Homo sapiens	88-93
28355296-10	2017	Interestingly, a specific phosphoinositide 3-kinase (PI3K)/Akt inhibitor (LY294002) augmented the As4O6 induced cell death; whereas p38 mitogen-activated protein kinases (p38 MAPK) inhibitor (SB203580) abrogated the cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	26-51
28355296-10	2017	Interestingly, a specific phosphoinositide 3-kinase (PI3K)/Akt inhibitor (LY294002) augmented the As4O6 induced cell death; whereas p38 mitogen-activated protein kinases (p38 MAPK) inhibitor (SB203580) abrogated the cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	59-62
28154340-7	2017	Both GFRalpha1 siRNA and LY294002, as upstream blockers, reduced POU3F1 expression induced by YC extract.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	POU domain, class 3, transcription factor 1	Mus musculus	65-71
28327179-8	2017	Mechanistically, PS-induced AKT phosphorylation (pAKT) and suppressed ERK phosphorylation (pERK) in suspended LLC cells, whereas pretreatment with a PI3K inhibitor, LY294002, effectively reduced pAKT, rescued pERK, and consequently reversed the PS-suppressed polyFN assembly on LLC cells; these pretreatment effects were then overturned by the ERK inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	209-213
28386321-8	2017	However, the PI3K/Akt inhibitor LY294002 reversed the protective effects of aFGF on neurofunctional deficits and junction protein expression and significantly suppressed p-Akt and GTP-Rac1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	fibroblast growth factor 1	Homo sapiens	76-80
28386321-8	2017	However, the PI3K/Akt inhibitor LY294002 reversed the protective effects of aFGF on neurofunctional deficits and junction protein expression and significantly suppressed p-Akt and GTP-Rac1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	172-175
28386321-8	2017	However, the PI3K/Akt inhibitor LY294002 reversed the protective effects of aFGF on neurofunctional deficits and junction protein expression and significantly suppressed p-Akt and GTP-Rac1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	Rac family small GTPase 1	Homo sapiens	184-188
28446279-3	2017	At the same time, the the inhibitor LY294002 of PI3K/AKT signaling pathway was used to treat the cells, so as to explore whether the changes of HL-60 sensitivity is associated with the activation of PI3K/AKT signal pathway after co-culture of cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	53-56
28327554-5	2017	However, the effects of PPARbeta/delta on VSMC phenotypic switch were partly obstacled in the presence of LY294002, a potent inhibitor of Phosphatidyl-Inositol-3 Kinase-AKT (PI3K/AKT).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	peroxisome proliferator-activated receptor delta	Rattus norvegicus	24-32
28327554-5	2017	However, the effects of PPARbeta/delta on VSMC phenotypic switch were partly obstacled in the presence of LY294002, a potent inhibitor of Phosphatidyl-Inositol-3 Kinase-AKT (PI3K/AKT).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	AKT serine/threonine kinase 1	Rattus norvegicus	169-172
28327554-5	2017	However, the effects of PPARbeta/delta on VSMC phenotypic switch were partly obstacled in the presence of LY294002, a potent inhibitor of Phosphatidyl-Inositol-3 Kinase-AKT (PI3K/AKT).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	174-182
28303030-8	2017	Moreover, it was found that the activation of FPRs increased the generation of reactive oxygen species (ROS) and phosphorylation of AKT in the NSCs, while N-acetylcysteine and LY294002 inhibited the FPRs-stimulated increase in ROS generation and AKT phosphorylation, and blocked the FPRs-stimulated neural differentiation into neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	thymoma viral proto-oncogene 1	Mus musculus	246-249
28185818-6	2017	Further study disclosed that AF enhanced the phosphorylation of PI3K, Akt and ERK1/2 down-regulated by MPP+ in SH-SY5Y cells, the effect of which could be blocked by LY294002, the inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	AKT serine/threonine kinase 1	Homo sapiens	70-73
27925189-7	2017	The specific PI3K inhibitor Ly294002 inhibited the effects of pcDNA3.1-afp vectors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	alpha fetoprotein	Homo sapiens	71-74
28185818-6	2017	Further study disclosed that AF enhanced the phosphorylation of PI3K, Akt and ERK1/2 down-regulated by MPP+ in SH-SY5Y cells, the effect of which could be blocked by LY294002, the inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	mitogen-activated protein kinase 3	Homo sapiens	78-84
28407679-7	2017	Ectopic expression of wild-type PAK4 in MDA-MB-231 cells activated PI3K/AKT signaling and resulted in the enhancement of the cell proliferation, migration, and invasion, whereas PAK4-induced effects were blocked by the PAK4 kinase inhibitor PF- 3758309, PAK4 siRNAs or the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	288-296	p21 (RAC1) activated kinase 4	Homo sapiens	32-36
28407679-7	2017	Ectopic expression of wild-type PAK4 in MDA-MB-231 cells activated PI3K/AKT signaling and resulted in the enhancement of the cell proliferation, migration, and invasion, whereas PAK4-induced effects were blocked by the PAK4 kinase inhibitor PF- 3758309, PAK4 siRNAs or the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	288-296	p21 (RAC1) activated kinase 4	Homo sapiens	178-182
28407679-7	2017	Ectopic expression of wild-type PAK4 in MDA-MB-231 cells activated PI3K/AKT signaling and resulted in the enhancement of the cell proliferation, migration, and invasion, whereas PAK4-induced effects were blocked by the PAK4 kinase inhibitor PF- 3758309, PAK4 siRNAs or the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	288-296	p21 (RAC1) activated kinase 4	Homo sapiens	178-182
28407679-7	2017	Ectopic expression of wild-type PAK4 in MDA-MB-231 cells activated PI3K/AKT signaling and resulted in the enhancement of the cell proliferation, migration, and invasion, whereas PAK4-induced effects were blocked by the PAK4 kinase inhibitor PF- 3758309, PAK4 siRNAs or the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	288-296	p21 (RAC1) activated kinase 4	Homo sapiens	178-182
28129651-6	2017	The selective phosphoinositide 3-kinase (PI3K) inhibitor LY294002 and dominant negative p85 vector (DNDeltap85) transfection effectively abolished these HG-induced responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	14-39
28288190-6	2017	Moreover, co-treatment with LY294002 (PI3K inhibitor) could further enhance the Tet-inhibited migration and invasion, and the NF-kappaB and MMP-9 protein levels were further decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	nuclear factor kappa B subunit 1	Homo sapiens	126-135
28288190-6	2017	Moreover, co-treatment with LY294002 (PI3K inhibitor) could further enhance the Tet-inhibited migration and invasion, and the NF-kappaB and MMP-9 protein levels were further decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	matrix metallopeptidase 9	Homo sapiens	140-145
29931939-6	2017	After addition of PI3K inhibitor LY294002, the protein and mRNA levels of Akt and Cx43 were decreased in LY294002 group, while the incidence rate of reperfusion arrhythmias was significantly higher and the left ventricular function were evidently damaged compared with Res group(P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
29931939-6	2017	After addition of PI3K inhibitor LY294002, the protein and mRNA levels of Akt and Cx43 were decreased in LY294002 group, while the incidence rate of reperfusion arrhythmias was significantly higher and the left ventricular function were evidently damaged compared with Res group(P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	gap junction protein, alpha 1	Rattus norvegicus	82-86
29931939-6	2017	After addition of PI3K inhibitor LY294002, the protein and mRNA levels of Akt and Cx43 were decreased in LY294002 group, while the incidence rate of reperfusion arrhythmias was significantly higher and the left ventricular function were evidently damaged compared with Res group(P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
29931939-6	2017	After addition of PI3K inhibitor LY294002, the protein and mRNA levels of Akt and Cx43 were decreased in LY294002 group, while the incidence rate of reperfusion arrhythmias was significantly higher and the left ventricular function were evidently damaged compared with Res group(P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	gap junction protein, alpha 1	Rattus norvegicus	82-86
28199981-7	2017	Moreover, a PI3K inhibitor LY294002 inhibited AKT/GSK-3beta/beta-catenin pathway activated by GDF15 and attenuated GDF15-induced proliferation, colony formation and invasion of SCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	46-49
28199981-7	2017	Moreover, a PI3K inhibitor LY294002 inhibited AKT/GSK-3beta/beta-catenin pathway activated by GDF15 and attenuated GDF15-induced proliferation, colony formation and invasion of SCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	glycogen synthase kinase 3 beta	Homo sapiens	50-59
28199981-7	2017	Moreover, a PI3K inhibitor LY294002 inhibited AKT/GSK-3beta/beta-catenin pathway activated by GDF15 and attenuated GDF15-induced proliferation, colony formation and invasion of SCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	catenin beta 1	Homo sapiens	60-72
28129651-7	2017	Moreover, HG markedly increased the cyclin kinase inhibitor p27Kip1 protein expression, which could be inhibited by LY294002 or transfection of DNDeltap85.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	60-67
28199981-7	2017	Moreover, a PI3K inhibitor LY294002 inhibited AKT/GSK-3beta/beta-catenin pathway activated by GDF15 and attenuated GDF15-induced proliferation, colony formation and invasion of SCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	growth differentiation factor 15	Homo sapiens	94-99
28011582-6	2017	Furthermore, inhibition of the PI3K pathway (LY294002) substantially inhibited FSS activation of alpha5beta1-integrin, upregulation of COX-2 gene and protein expression, and release of PGI2 in BAECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	prostaglandin-endoperoxide synthase 2	Mus musculus	135-140
28199981-7	2017	Moreover, a PI3K inhibitor LY294002 inhibited AKT/GSK-3beta/beta-catenin pathway activated by GDF15 and attenuated GDF15-induced proliferation, colony formation and invasion of SCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	growth differentiation factor 15	Homo sapiens	115-120
28085149-9	2017	Similarly, transfection of the dominant-negative form of Akt in NSC-34 motor neurons and treatment with the selective PI3K inhibitor LY294002 prevented ApoSOD1- and SOD1-mediated neuroprotective effects in L-BMAA-treated motor neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	AKT serine/threonine kinase 1	Homo sapiens	57-60
27988307-7	2017	We observed that utrophin mRNA induction was abolished by BAPTA-AM (an intracellular Ca2+ chelator), GM6001 (a general metalloproteinase inhibitor), genistein (a general protein tyrosine kinase inhibitor), PD-158780 (an ErbB receptor tyrosine kinase inhibitor) and PD-98059 (a MEK inhibitor), whereas Ly-294002 and wortmannin (PI3K inhibitors) did not affect utrophin induction evoked by IL-6 in dystrophic myotubes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	301-310	utrophin	Homo sapiens	17-25
28085149-9	2017	Similarly, transfection of the dominant-negative form of Akt in NSC-34 motor neurons and treatment with the selective PI3K inhibitor LY294002 prevented ApoSOD1- and SOD1-mediated neuroprotective effects in L-BMAA-treated motor neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	superoxide dismutase 1	Homo sapiens	155-159
28235037-12	2017	LY294002, an inhibitor of phosphatidylinositol-3 kinase/Akt pathway, suppressed the canstatin-induced Akt phosphorylation and reversed the protective effects of canstatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	56-59
27991908-8	2017	Treatment with HSC-CM promoted AHPCs proliferation and resulted in increased pAkt expression in vitro, and this effect was abolished by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	thymoma viral proto-oncogene 1	Mus musculus	78-81
27090441-7	2017	The effects of IGF-1 could be blocked by the extracellular signal-regulated protein kinase (ERK1/2) inhibitor PD98059 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, either alone or in combination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	insulin like growth factor 1	Homo sapiens	15-20
27090441-7	2017	The effects of IGF-1 could be blocked by the extracellular signal-regulated protein kinase (ERK1/2) inhibitor PD98059 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, either alone or in combination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	126-155
28274303-5	2017	In another group, mDCs were incubated with 25 mumol/L LY294002 (PI3K/Akt inhibitor), 1 mumol/L SB203580 (p38MAPK inhibitor), 100 nmol/L SP600125 (JNK inhibitor) and 150 nmol/L U0126 (ERK inhibitor) for 1 hour separately, and then stimulated by 10 mug/mL rhHBcAg for another 48 hours.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	64-86
28099936-6	2017	In addition, Akt activity manipulated by PI3K inhibitor LY294002 or Akt mutants was shown to negatively affect FOXO1-mediated HBP1 promoter activation and gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	13-16
28099936-6	2017	In addition, Akt activity manipulated by PI3K inhibitor LY294002 or Akt mutants was shown to negatively affect FOXO1-mediated HBP1 promoter activation and gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	forkhead box O1	Homo sapiens	111-116
28099936-6	2017	In addition, Akt activity manipulated by PI3K inhibitor LY294002 or Akt mutants was shown to negatively affect FOXO1-mediated HBP1 promoter activation and gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	HMG-box transcription factor 1	Homo sapiens	126-130
28367103-8	2017	PI3K/AKT inhibitor LY294002 and mTORC1 inhibitor Rapamycin inhibit alpha-MSH-induced dendrites.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	5-8
28367103-8	2017	PI3K/AKT inhibitor LY294002 and mTORC1 inhibitor Rapamycin inhibit alpha-MSH-induced dendrites.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	proopiomelanocortin	Homo sapiens	67-76
28122344-10	2017	LY294002, a PI3K/Akt inhibitor, significantly suppressed the CGA-induced Nrf2 nuclear translocation and HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	17-20
28122344-10	2017	LY294002, a PI3K/Akt inhibitor, significantly suppressed the CGA-induced Nrf2 nuclear translocation and HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
28122344-10	2017	LY294002, a PI3K/Akt inhibitor, significantly suppressed the CGA-induced Nrf2 nuclear translocation and HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heme oxygenase 1	Mus musculus	104-108
28235037-12	2017	LY294002, an inhibitor of phosphatidylinositol-3 kinase/Akt pathway, suppressed the canstatin-induced Akt phosphorylation and reversed the protective effects of canstatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
28289332-10	2017	The Wnt5a-induced activation of RhoA was mostly blocked by pretreatment of LY294002 (PI3K inhibitor) and MK-2206 (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	Wnt family member 5A	Homo sapiens	4-9
27923634-12	2017	Finally, the Akt inhibitor LY294002 reversed all the protective effects of RA, indicating that RA protects neurons in the hippocampal CA1 region from ischemic damage through the Akt/JNK3/caspase-3 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
27923634-12	2017	Finally, the Akt inhibitor LY294002 reversed all the protective effects of RA, indicating that RA protects neurons in the hippocampal CA1 region from ischemic damage through the Akt/JNK3/caspase-3 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	carbonic anhydrase 1	Rattus norvegicus	134-137
27923634-12	2017	Finally, the Akt inhibitor LY294002 reversed all the protective effects of RA, indicating that RA protects neurons in the hippocampal CA1 region from ischemic damage through the Akt/JNK3/caspase-3 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	178-181
27923634-12	2017	Finally, the Akt inhibitor LY294002 reversed all the protective effects of RA, indicating that RA protects neurons in the hippocampal CA1 region from ischemic damage through the Akt/JNK3/caspase-3 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	mitogen activated protein kinase 10	Rattus norvegicus	182-186
27923634-12	2017	Finally, the Akt inhibitor LY294002 reversed all the protective effects of RA, indicating that RA protects neurons in the hippocampal CA1 region from ischemic damage through the Akt/JNK3/caspase-3 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	caspase 3	Rattus norvegicus	187-196
28095306-7	2017	Additionally, Ly294002, a chemical inhibitor of PI3K/Akt, could dramatically down-regulate the hallmarks of M2 macrophages.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	thymoma viral proto-oncogene 1	Mus musculus	53-56
28076326-6	2017	Treatment with the AKT inhibitor, LY294002, reduced the effects of THUMPD1 overexpression in breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	19-22
28076326-6	2017	Treatment with the AKT inhibitor, LY294002, reduced the effects of THUMPD1 overexpression in breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	THUMP domain containing 1	Homo sapiens	67-74
28190476-11	2017	Blockade of PI3K/Akt or MEK/ERK signaling pathway by LY294002 or PD98059 could attenuate the increase of DA content in the striatum and TH-IR in the SNpc induced by icariin in PD mice model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	thymoma viral proto-oncogene 1	Mus musculus	17-20
28190476-11	2017	Blockade of PI3K/Akt or MEK/ERK signaling pathway by LY294002 or PD98059 could attenuate the increase of DA content in the striatum and TH-IR in the SNpc induced by icariin in PD mice model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	midkine	Mus musculus	24-27
28190476-11	2017	Blockade of PI3K/Akt or MEK/ERK signaling pathway by LY294002 or PD98059 could attenuate the increase of DA content in the striatum and TH-IR in the SNpc induced by icariin in PD mice model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	mitogen-activated protein kinase 1	Mus musculus	28-31
28099911-7	2017	The increase of pAkt, pERK1/2 and cyclin D1 by bradykinin was prevented by the PI3K inhibitor Ly294002, the PLC inhibitors U73122 and neomycin, and/or the PKC inhibitor chelerythrine and the MAPK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	cyclin D1	Homo sapiens	34-43
28099911-7	2017	The increase of pAkt, pERK1/2 and cyclin D1 by bradykinin was prevented by the PI3K inhibitor Ly294002, the PLC inhibitors U73122 and neomycin, and/or the PKC inhibitor chelerythrine and the MAPK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	kininogen 1	Homo sapiens	47-57
28289332-10	2017	The Wnt5a-induced activation of RhoA was mostly blocked by pretreatment of LY294002 (PI3K inhibitor) and MK-2206 (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	ras homolog family member A	Homo sapiens	32-36
27916558-12	2017	Furthermore, pretreatment with CAR markedly increased the activation of Akt/eNOS pathway in cardiomyocytes subjected to H/R, and the protective effects of CAR were abolished in the presence of the Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	211-219	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
28057758-5	2017	LY-294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), and BAY 11-7082, an NF-kappaB inhibitor, decreased claudin-2 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	claudin 2	Homo sapiens	116-125
28057758-6	2017	The reporter activity of claudin-2 was decreased by AZA and LY-294002, which was blocked by the mutation in a putative NF-kappaB-binding site.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-69	claudin 2	Homo sapiens	25-34
28057758-6	2017	The reporter activity of claudin-2 was decreased by AZA and LY-294002, which was blocked by the mutation in a putative NF-kappaB-binding site.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-69	nuclear factor kappa B subunit 1	Homo sapiens	119-128
28057758-7	2017	NF-kappaB bound to the promoter region of claudin-2, which was inhibited by AZA and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-93	nuclear factor kappa B subunit 1	Homo sapiens	0-9
28057758-7	2017	NF-kappaB bound to the promoter region of claudin-2, which was inhibited by AZA and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-93	claudin 2	Homo sapiens	42-51
27916558-12	2017	Furthermore, pretreatment with CAR markedly increased the activation of Akt/eNOS pathway in cardiomyocytes subjected to H/R, and the protective effects of CAR were abolished in the presence of the Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	211-219	AKT serine/threonine kinase 1	Rattus norvegicus	197-200
27884393-7	2017	VEGF165-induced barrier dysfunction was accompanied by disruption of the epithelial E-cadherin and beta-catenin, pretreatment of 1,25(OH)2D3 and LY294002 markedly attenuated VEGF-induced airway barrier disruption in 16HBE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	cadherin 1	Homo sapiens	84-94
28034780-4	2017	The inhibitory effects of Form were associated with PI3K/Akt signaling pathway as PI3K inhibitor (LY294002) or ERalpha specific inhibitor (MPP) blocked the effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	thymoma viral proto-oncogene 1	Mus musculus	57-60
27884393-7	2017	VEGF165-induced barrier dysfunction was accompanied by disruption of the epithelial E-cadherin and beta-catenin, pretreatment of 1,25(OH)2D3 and LY294002 markedly attenuated VEGF-induced airway barrier disruption in 16HBE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	catenin beta 1	Homo sapiens	99-111
27884393-7	2017	VEGF165-induced barrier dysfunction was accompanied by disruption of the epithelial E-cadherin and beta-catenin, pretreatment of 1,25(OH)2D3 and LY294002 markedly attenuated VEGF-induced airway barrier disruption in 16HBE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	vascular endothelial growth factor A	Homo sapiens	0-4
28000865-0	2017	PI3K inhibitor LY294002, as opposed to wortmannin, enhances AKT phosphorylation in gemcitabine-resistant pancreatic cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	60-63
28017896-11	2017	Both alloxan and specific inhibitors of PI3K (Wortmannin and LY294002) blocked the protection of glucosamine via inhibiting Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Rattus norvegicus	124-127
28025122-7	2017	The pharmaceutical inhibitors, such as KN-93 (CaMKII inhibitor) and LY294002 (Akt inhibitor) suppressed rutaecarpine-induced HO-1 expression and cytoprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	78-81
27448447-11	2017	Treatment with Ant-21, or the pan-PI3K inhibitor LY294002, reduced PI3K activity and restored HDAC2 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	histone deacetylase 2	Homo sapiens	94-99
27982695-12	2017	However, the Akt inhibitor, LY294002, partially hampered the effects of 17-DMAG on the expression of p-Akt, nuclear Nrf2, and HO-1 and cell viability, as well as cell apoptosis induced by H/R in HT22 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	thymoma viral proto-oncogene 1	Mus musculus	13-16
27982695-12	2017	However, the Akt inhibitor, LY294002, partially hampered the effects of 17-DMAG on the expression of p-Akt, nuclear Nrf2, and HO-1 and cell viability, as well as cell apoptosis induced by H/R in HT22 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	thymoma viral proto-oncogene 1	Mus musculus	103-106
27982695-12	2017	However, the Akt inhibitor, LY294002, partially hampered the effects of 17-DMAG on the expression of p-Akt, nuclear Nrf2, and HO-1 and cell viability, as well as cell apoptosis induced by H/R in HT22 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
27982695-12	2017	However, the Akt inhibitor, LY294002, partially hampered the effects of 17-DMAG on the expression of p-Akt, nuclear Nrf2, and HO-1 and cell viability, as well as cell apoptosis induced by H/R in HT22 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	heme oxygenase 1	Mus musculus	126-130
28000865-4	2017	Inhibiting AKT phosphorylation by treatment with AKTi-1/2 or wortmannin further enhanced LY294002-induced cell death in PK59 and KLM1-R cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	AKT serine/threonine kinase 1	Homo sapiens	11-14
28000865-3	2017	In this study, LY294002 (but not wortmannin) showed an abnormal ability to enhance AKT phosphorylation (at Ser472) specifically in gemcitabine (GEM)-resistant pancreatic cancer (PC) cell lines PK59 and KLM1-R. LY294002 was shown to activate AKT and accumulate phospho-AKT at the intracellular membrane in PK59, which was abolished by treatment with AKTi-1/2 or wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	83-86
28000865-6	2017	Thus, our results reveal that LY294002 displays the opposite effect on PI3K-dependent AKT phosphorylation, which maintains cell survival from the cytotoxicity introduced by LY294002 itself in GEM-resistant pancreatic cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	86-89
28000865-6	2017	Thus, our results reveal that LY294002 displays the opposite effect on PI3K-dependent AKT phosphorylation, which maintains cell survival from the cytotoxicity introduced by LY294002 itself in GEM-resistant pancreatic cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	AKT serine/threonine kinase 1	Homo sapiens	86-89
28000865-3	2017	In this study, LY294002 (but not wortmannin) showed an abnormal ability to enhance AKT phosphorylation (at Ser472) specifically in gemcitabine (GEM)-resistant pancreatic cancer (PC) cell lines PK59 and KLM1-R. LY294002 was shown to activate AKT and accumulate phospho-AKT at the intracellular membrane in PK59, which was abolished by treatment with AKTi-1/2 or wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	241-244
28000865-3	2017	In this study, LY294002 (but not wortmannin) showed an abnormal ability to enhance AKT phosphorylation (at Ser472) specifically in gemcitabine (GEM)-resistant pancreatic cancer (PC) cell lines PK59 and KLM1-R. LY294002 was shown to activate AKT and accumulate phospho-AKT at the intracellular membrane in PK59, which was abolished by treatment with AKTi-1/2 or wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	241-244
27302072-9	2017	Therefore, antagonizing Akt signaling using a chemical inhibitor LY294002, we found that NUMB6-induced Slug expression was reduced, and ultimately accompanied with decreased cell migration and invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	snail family transcriptional repressor 2	Homo sapiens	103-107
25136768-9	2017	Either extracellular signal-regulated protein kinase (ERK1/2) inhibitor PD98059 or phosphatidylinositol 3-kinase (PI3 K) inhibitor LY294002 blocked the effect of IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	83-112
27171670-9	2017	In addition, the phosphorylation of AKT and ERK1/2 was suppressed by LY294002 and U0126 in JEG-3 cells treated with chrysophanol, whereas, the AKT protein was activated by pre-treatment of JEG-3 cells with U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	36-39
27171670-9	2017	In addition, the phosphorylation of AKT and ERK1/2 was suppressed by LY294002 and U0126 in JEG-3 cells treated with chrysophanol, whereas, the AKT protein was activated by pre-treatment of JEG-3 cells with U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	mitogen-activated protein kinase 3	Homo sapiens	44-50
27171670-9	2017	In addition, the phosphorylation of AKT and ERK1/2 was suppressed by LY294002 and U0126 in JEG-3 cells treated with chrysophanol, whereas, the AKT protein was activated by pre-treatment of JEG-3 cells with U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	143-146
28078613-7	2017	Those effects were blocked by the specific PI3K inhibitor, LY294002, indicating the involvement of Akt/GSK-3beta pathway in the neuroprotective effect of L-F001.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	thymoma viral proto-oncogene 1	Mus musculus	99-102
28078613-7	2017	Those effects were blocked by the specific PI3K inhibitor, LY294002, indicating the involvement of Akt/GSK-3beta pathway in the neuroprotective effect of L-F001.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	glycogen synthase kinase 3 beta	Mus musculus	103-112
27506476-7	2017	These IPPKKNQDKTE-mediated protection effects were reversed by PI3K/Akt inhibitor LY294002, showing the mediatory role of PI3K/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	68-71
27506476-7	2017	These IPPKKNQDKTE-mediated protection effects were reversed by PI3K/Akt inhibitor LY294002, showing the mediatory role of PI3K/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	127-130
25136768-9	2017	Either extracellular signal-regulated protein kinase (ERK1/2) inhibitor PD98059 or phosphatidylinositol 3-kinase (PI3 K) inhibitor LY294002 blocked the effect of IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	insulin-like growth factor 1	Rattus norvegicus	162-167
27975125-8	2017	We found that intracerebroventricular injection of the selective MAPK/ERK inhibitor U0126 (5 mug/2 mul) and the selective PI3K inhibitor LY294002 (10 nmol/2 mul) significantly inhibited the anti-immobility effect of Lu AA33810 in the FST in rats, suggesting that MAPK/ERK and PI3K signaling pathways could be involved in the antidepressant-like effect of Lu AA33810.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	Eph receptor B1	Rattus norvegicus	268-271
27940357-10	2017	Moreover, the Akt inhibitor LY294002 reversed the anti-apoptotic effects of high insulin in the ovary tissues in early pregnancy mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	thymoma viral proto-oncogene 1	Mus musculus	14-17
27940357-10	2017	Moreover, the Akt inhibitor LY294002 reversed the anti-apoptotic effects of high insulin in the ovary tissues in early pregnancy mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	insulin	Homo sapiens	81-88
27817185-4	2017	Correspondingly, concomitant treatment with the autophagy inhibitor (3-methyladenine or LY294002) appeared to enhance acacetin-induced apoptotic responses, such as Bak activation, Deltapsi loss, activation of caspase-9 and caspase-3, and apoptotic sub-G1 accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	BCL2 antagonist/killer 1	Homo sapiens	164-167
27817185-4	2017	Correspondingly, concomitant treatment with the autophagy inhibitor (3-methyladenine or LY294002) appeared to enhance acacetin-induced apoptotic responses, such as Bak activation, Deltapsi loss, activation of caspase-9 and caspase-3, and apoptotic sub-G1 accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	caspase 9	Homo sapiens	209-218
27817185-4	2017	Correspondingly, concomitant treatment with the autophagy inhibitor (3-methyladenine or LY294002) appeared to enhance acacetin-induced apoptotic responses, such as Bak activation, Deltapsi loss, activation of caspase-9 and caspase-3, and apoptotic sub-G1 accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	caspase 3	Homo sapiens	223-232
28103884-13	2017	Importantly, inhibition of PI3K/Akt pathway by LY294002 completely blocked the TCDD-induced SP cells expansion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	32-35
27908726-9	2017	However, the neuroprotective effects of G-1 on spatial cognition and neuronal death were attenuated by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Rattus norvegicus	108-111
27921103-6	2017	Solanesol activated both p38 and Akt, and treatments with SB203580 (a p38 kinase inhibitor), LY294002 (an Akt inhibitor), specific p38 siRNA and Akt siRNA suppressed the solanesol-induced activation of Nrf2, resulting in a decrease in HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	nuclear factor, erythroid derived 2, like 2	Mus musculus	202-206
28067275-2	2017	We showed that the migration of hDPSCs was induced by SDF-1 in a concentration-dependent manner and could be inhibited with siCXCR4 (C-X-C chemokine receptor type 4) and siCDC42 (cell division control protein 42), as well as drug inhibitors such as AMD3100 (antagonist of CXCR4), LY294002 (inhibitor of PI3K) and PF573228 (inhibitor of FAK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-288	C-X-C motif chemokine ligand 12	Homo sapiens	54-59
27702388-10	2017	Moreover, AG1478, LY294002, and U0126 significantly decreased p-EGFR, p-AKT, and p-ERK1/2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	epidermal growth factor receptor	Homo sapiens	64-68
27702388-10	2017	Moreover, AG1478, LY294002, and U0126 significantly decreased p-EGFR, p-AKT, and p-ERK1/2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	72-75
27702388-10	2017	Moreover, AG1478, LY294002, and U0126 significantly decreased p-EGFR, p-AKT, and p-ERK1/2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	mitogen-activated protein kinase 3	Homo sapiens	83-89
27911877-4	2017	Akt inhibitors (LY294002, perifosine and MK-2206) almost abolished icariside II-induced osteoblast cytoprotection against dexamethasone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	thymoma viral proto-oncogene 1	Mus musculus	0-3
27746366-12	2017	For further validation, results of the present study also demonstrated that PTEN/Akt/FOXO1 signaling was responsible for the ADR-resistance of breast cancer cells since LY294002, an inhibitor of Akt signaling, partially increased the sensitivity of MCF-7/S cells to ADR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	phosphatase and tensin homolog	Homo sapiens	76-80
27746366-12	2017	For further validation, results of the present study also demonstrated that PTEN/Akt/FOXO1 signaling was responsible for the ADR-resistance of breast cancer cells since LY294002, an inhibitor of Akt signaling, partially increased the sensitivity of MCF-7/S cells to ADR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Homo sapiens	81-84
27746366-12	2017	For further validation, results of the present study also demonstrated that PTEN/Akt/FOXO1 signaling was responsible for the ADR-resistance of breast cancer cells since LY294002, an inhibitor of Akt signaling, partially increased the sensitivity of MCF-7/S cells to ADR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	forkhead box O1	Homo sapiens	85-90
27746366-12	2017	For further validation, results of the present study also demonstrated that PTEN/Akt/FOXO1 signaling was responsible for the ADR-resistance of breast cancer cells since LY294002, an inhibitor of Akt signaling, partially increased the sensitivity of MCF-7/S cells to ADR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Homo sapiens	195-198
27939242-8	2017	The Nrf2 signaling pathway was determined using rottlerin (protein kinase [PK]Cdelta inhibitor), H89 (PKA inhibitor) and LY294002 (phosphatidylinositide 3-kinase [PI3K] inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	NFE2 like bZIP transcription factor 2	Rattus norvegicus	4-8
28079886-6	2017	Interestingly, HIV-1 Nef release in EVs was enriched significantly when the cells were treated with autophagy activators perifosine, tomaxifen, MG-132, and autophagy inhibitors LY294002 and wortmannin suggesting a novel role of autophagy signaling in HIV-1 Nef release from astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	Nef	Human immunodeficiency virus 1	21-24
28072855-3	2017	SDF-1alpha-induced platelet aggregation and Akt phosphorylation are inhibited by pretreatment with the CXCR4 antagonist AMD3100 or the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	AKT serine/threonine kinase 1	Homo sapiens	44-47
28168101-8	2017	Phen, the selective inhibitor of PTEN, reproduced the pro-proliferation effects of miR-21, while PI3K inhibitor, LY294002, totally attenuated the pro-survival effect of miR-21.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	microRNA 21	Homo sapiens	169-175
27827806-10	2017	Both rapamycin and PD-98059 inhibited the CIT effect on S6K1, whereas only LY-294002 inhibited the CIT effect on both S6K1 and 4E-BP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-84	ribosomal protein S6 kinase B1	Rattus norvegicus	118-133
27760741-8	2017	Moreover, NGF remarkably attenuated the phosphorylation effect of alcohol exposure on PI3K/Akt/mTOR pathway, which was suppressed by LY294002 (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
27760741-8	2017	Moreover, NGF remarkably attenuated the phosphorylation effect of alcohol exposure on PI3K/Akt/mTOR pathway, which was suppressed by LY294002 (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	mechanistic target of rapamycin kinase	Rattus norvegicus	95-99
27760741-8	2017	Moreover, NGF remarkably attenuated the phosphorylation effect of alcohol exposure on PI3K/Akt/mTOR pathway, which was suppressed by LY294002 (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	AKT serine/threonine kinase 1	Rattus norvegicus	143-146
28810254-7	2017	Furthermore, PI3-kinase inhibition by wortmannin decreased TNF-alpha release, and inhibition by LY294002 decreased both TNF-alpha and IL-6 levels after LPS-insulin treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	tumor necrosis factor	Mus musculus	120-129
28250268-9	2017	Treatment of the cells with specific inhibitors including SB203580, SP600125, and LY294002 suppressed the luteolin-induced HO-1 expression, suggesting the involvement of p38 MAPK, JNK, and Akt in HO-1 induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	mitogen activated protein kinase 14	Rattus norvegicus	170-173
28250268-9	2017	Treatment of the cells with specific inhibitors including SB203580, SP600125, and LY294002 suppressed the luteolin-induced HO-1 expression, suggesting the involvement of p38 MAPK, JNK, and Akt in HO-1 induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	mitogen-activated protein kinase 8	Rattus norvegicus	180-183
28250268-9	2017	Treatment of the cells with specific inhibitors including SB203580, SP600125, and LY294002 suppressed the luteolin-induced HO-1 expression, suggesting the involvement of p38 MAPK, JNK, and Akt in HO-1 induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Rattus norvegicus	189-192
28691020-6	2017	Moreover, LY294002, a highly selective inhibitor of PI3K, blocked phosphorylation of Akt and the effects of miR-200c.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	85-88
28691020-6	2017	Moreover, LY294002, a highly selective inhibitor of PI3K, blocked phosphorylation of Akt and the effects of miR-200c.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	microRNA 200c	Homo sapiens	108-116
28985493-6	2017	Moreover, the expression of p-Akt and p-mTOR was down-regulated after treatment with kaempferol in ox-LDL-treated HUVECs, which is similar to the effect of PI3K inhibitor (LY294002) or mTOR inhibitor [rapamycin (RAP)].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	AKT serine/threonine kinase 1	Homo sapiens	30-33
28540295-16	2017	However, with preadministration of PI3K/Akt pathway inhibitor LY294002, the effect of RLX was blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	AKT serine/threonine kinase 1	Homo sapiens	40-43
28810254-7	2017	Furthermore, PI3-kinase inhibition by wortmannin decreased TNF-alpha release, and inhibition by LY294002 decreased both TNF-alpha and IL-6 levels after LPS-insulin treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	interleukin 6	Mus musculus	134-138
29040978-10	2017	After adding the PI3K signaling pathway inhibitor, LY294002, to rat cerebral microvascular endothelial cells (CMECs), HRS could reduce activated Akt expression and downstream regulatory gene phosphorylation of GSK3beta expression, and inhibit CMEC apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
28957813-10	2017	Inhibition of alpha7 nAChR significantly decreased Akt phosphorylation levels, and LY294002 inhibited the protein expression levels of TRPC6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	transient receptor potential cation channel subfamily C member 6	Homo sapiens	135-140
29040978-10	2017	After adding the PI3K signaling pathway inhibitor, LY294002, to rat cerebral microvascular endothelial cells (CMECs), HRS could reduce activated Akt expression and downstream regulatory gene phosphorylation of GSK3beta expression, and inhibit CMEC apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	glycogen synthase kinase 3 beta	Rattus norvegicus	210-218
29176314-9	2017	Furthermore, the promotive effects of ZNF703 on cellular proliferation and metastasis could be rescued by LY294002 (a PI3K-specific inhibitor) and MK2206 (an Akt-specific inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	zinc finger protein 703	Homo sapiens	38-44
28176634-4	2017	Several agents have been developed to target the Akt/PI3K pathways, including PI3K inhibitors, (e.g. LY294002, Wortmannin), PI3K/mTOR inhibitors (e.g. BEZ235), or Akt inhibitors (e.g. perifosine, MK2206), which have been tested alone or in combinations with DNA-targeted agents (e.g., gemcitabine and fluorouracil) in pancreatic ductal adenocarcinoma (PDAC).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Homo sapiens	49-52
29055943-8	2017	Furthermore activation of Akt showed upregulated expression of the IL-6 protein whereas Akt inhibitor, LY294002 or Akt siRNA significantly inhibited SIRT1-regulated IL-6 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	sirtuin 1	Homo sapiens	149-154
29055943-8	2017	Furthermore activation of Akt showed upregulated expression of the IL-6 protein whereas Akt inhibitor, LY294002 or Akt siRNA significantly inhibited SIRT1-regulated IL-6 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	interleukin 6	Homo sapiens	165-169
27887985-6	2017	Moreover, LY294002, a specific PI3K inhibitor, was found to completely abolish the protective effect of IGF-1 on Abeta25-35-induced apoptosis and ROS generation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	insulin like growth factor 1	Homo sapiens	104-109
29259641-7	2017	When the PI3K/AKT pathway was blocked by LY294002, a specific inhibitor of this pathway, the protective effect of icariin was impaired.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	14-17
27840966-10	2017	In addition, HS-1793 suppressed Akt and the phosphatidylinositol-3 kinase/Akt inhibitor LY294002 was found to enhance its induction of apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Homo sapiens	74-77
28123468-6	2017	The present study aimed to analyze the role of PI3K/AKT pathway in hypoxia-induced proliferation of BM-MSCs and their differentiation into endothelial cells in vitro by the application of LY294002, a PI3K/AKT pathway inhibitor, with cells cultured in normoxia serving as a control.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
27401686-8	2017	Finally, treatment with the PI 3-kinase inhibitor LY294002, which decreases PtdIns(3,4,5)P3 levels, rescued the cellular, phenotypic, and renal functional defects in inpp5e-knockdown embryos.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	inositol polyphosphate-5-phosphatase E	Homo sapiens	166-172
28536643-4	2017	LY294002 is a selective inhibitor of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	41-66
28536643-4	2017	LY294002 is a selective inhibitor of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
27510267-4	2017	We found that neuroserpin enhanced the activation of AKT in cultures subjected to oxidative stress and that the AKT inhibitor Ly294002 blocked this neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	AKT serine/threonine kinase 1	Homo sapiens	53-56
27510267-4	2017	We found that neuroserpin enhanced the activation of AKT in cultures subjected to oxidative stress and that the AKT inhibitor Ly294002 blocked this neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	AKT serine/threonine kinase 1	Homo sapiens	112-115
28250891-6	2017	In contrast, inhibition of Akt by LY294002 during ventilation reestablished lung damage, neutrophil influx, and proinflammatory cytokine release despite the presence of H2S.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	27-30
28123565-9	2017	Additionally, treatment using LY294002 significantly abrogated the promotion of Ki67 expression, growth and clone formation abilities induced by TNFR2 overexpression in SW1116 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	TNF receptor superfamily member 1B	Homo sapiens	145-150
27556731-0	2017	Comprehensive attenuation of IL-25-induced airway hyperresponsiveness, inflammation and remodelling by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	interleukin 25	Mus musculus	29-34
27222231-9	2017	Both LY294002 (an inhibitor of PI3K) and 10-DEBC (an inhibitor of Akt) significantly reduced 17beta-estradiol-induced SC proliferation and reduced mRNA and protein expression of Skp2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	S-phase kinase associated protein 2	Homo sapiens	178-182
27222231-10	2017	In addition, LY294002 inhibited 17beta-estradiol-induced activation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	71-74
29057033-9	2017	These results and the experiments involving N-acetyl cysteine (antioxidant), Cyclosporin A (mitochondrial protector), and LY294002 (Akt inhibitor) suggest that PD prevents MGO-induced HUVEC apoptosis, at least in part, through inhibiting oxidative stress, maintaining mitochondrial function, and activating Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Homo sapiens	132-135
27888070-5	2017	LY294002 did not impact PM-induced ovotoxicity, but decreased ABCC1 and ABCB1 protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ATP binding cassette subfamily C member 1	Homo sapiens	62-67
27888070-5	2017	LY294002 did not impact PM-induced ovotoxicity, but decreased ABCC1 and ABCB1 protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	72-77
27556731-3	2017	Using an established IL-25-induced murine model of asthma, we undertook a comprehensive evaluation of the effects of co-administered LY294002, a pharmacological pan-inhibitor of PI3K on IL-25-induced changes on this model, with particular regard to airway remodelling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	interleukin 25	Mus musculus	186-191
27556731-7	2017	RESULTS: Intranasal administration of LY294002 significantly inhibited IL-25-induced AHR and recruitment of inflammatory cells into bronchoalveolar lavage fluid.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	interleukin 25	Mus musculus	71-76
27556731-8	2017	LY294002 also attenuated IL-25-induced increased concentrations of cytokines and chemokines in lung tissue.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 25	Mus musculus	25-30
27556731-9	2017	Histological and immunohistochemical analysis showed that LY294002 also significantly inhibited IL-25-induced lung tissue eosinophilia, mucus production, collagen deposition, smooth muscle hypertrophy and angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	interleukin 25	Mus musculus	96-101
27556731-10	2017	CONCLUSION: The PI3K pan-inhibitor LY294002 attenuated not only IL-25-induced asthma-like AHR and airway inflammation but also remodelling in this model, suggesting that PI3K is a major downstream messenger for IL-25 and that targeting this pathway might reduce asthma symptoms in the short term and airway remodelling in the longer term.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	interleukin 25	Mus musculus	64-69
27556731-10	2017	CONCLUSION: The PI3K pan-inhibitor LY294002 attenuated not only IL-25-induced asthma-like AHR and airway inflammation but also remodelling in this model, suggesting that PI3K is a major downstream messenger for IL-25 and that targeting this pathway might reduce asthma symptoms in the short term and airway remodelling in the longer term.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	interleukin 25	Mus musculus	211-216
27751602-7	2017	In addition, LY294002 (20 muM) significantly inhibited changes in ratio of LC3B-II to LC3B-I, LC3B mRNA transcript levels, and autolysosome formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	latexin	Homo sapiens	26-29
27813328-12	2017	Moreover, the combination of ALDH1A1-short hairpin RNA and PI3K/AKT pathway inhibitor LY294002 markedly inhibited cell viability, enhanced apoptotic cell death, and increased cisplatin sensitivity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	AKT serine/threonine kinase 1	Homo sapiens	64-67
27751602-7	2017	In addition, LY294002 (20 muM) significantly inhibited changes in ratio of LC3B-II to LC3B-I, LC3B mRNA transcript levels, and autolysosome formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	microtubule associated protein 1 light chain 3 beta	Homo sapiens	75-79
27751602-7	2017	In addition, LY294002 (20 muM) significantly inhibited changes in ratio of LC3B-II to LC3B-I, LC3B mRNA transcript levels, and autolysosome formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	microtubule associated protein 1 light chain 3 beta	Homo sapiens	86-90
27751602-7	2017	In addition, LY294002 (20 muM) significantly inhibited changes in ratio of LC3B-II to LC3B-I, LC3B mRNA transcript levels, and autolysosome formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	microtubule associated protein 1 light chain 3 beta	Homo sapiens	86-90
27769787-10	2016	Furthermore, all of CTL"s protective effects were reversed by LY294002, which is a PI3K/Akt1 inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	AKT serine/threonine kinase 1	Rattus norvegicus	88-92
27998873-0	2016	[LY294002 blocks the effect of dexamethasone in reducing urine protein in rats by inhibiting PI3K/Akt signaling pathway].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	1-9	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
27998873-1	2016	OBJECTIVE: To investigate the involvement of PI3K/Akt signaling pathway in the changes of urine protein in adriamycin-induced nephropathic rats treated with dexamethasone and LY294002 (a PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	AKT serine/threonine kinase 1	Rattus norvegicus	50-53
27998873-9	2016	LY294002 can inhibit PI3K/Akt signaling pathway to block the effect of dexamethasone, suggesting that PI3K/Akt signaling pathway is one of the signaling pathways that mediate the effect of dexamethasone on proteinuria.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	26-29
27998873-9	2016	LY294002 can inhibit PI3K/Akt signaling pathway to block the effect of dexamethasone, suggesting that PI3K/Akt signaling pathway is one of the signaling pathways that mediate the effect of dexamethasone on proteinuria.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
28097093-5	2017	Treatment of human umbilical vein endothelial cells (HUVECs) with Akt inhibitor LY294002 results in diminished miR-20a and miR-31 production, while Erk inhibitor U0126 prevented VEGF-stimulated expression of miR-20a but not that of miR-31.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	66-69
28097093-5	2017	Treatment of human umbilical vein endothelial cells (HUVECs) with Akt inhibitor LY294002 results in diminished miR-20a and miR-31 production, while Erk inhibitor U0126 prevented VEGF-stimulated expression of miR-20a but not that of miR-31.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	microRNA 20a	Homo sapiens	111-118
28097093-5	2017	Treatment of human umbilical vein endothelial cells (HUVECs) with Akt inhibitor LY294002 results in diminished miR-20a and miR-31 production, while Erk inhibitor U0126 prevented VEGF-stimulated expression of miR-20a but not that of miR-31.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	microRNA 31	Homo sapiens	123-129
28097093-5	2017	Treatment of human umbilical vein endothelial cells (HUVECs) with Akt inhibitor LY294002 results in diminished miR-20a and miR-31 production, while Erk inhibitor U0126 prevented VEGF-stimulated expression of miR-20a but not that of miR-31.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	vascular endothelial growth factor A	Homo sapiens	178-182
28097093-5	2017	Treatment of human umbilical vein endothelial cells (HUVECs) with Akt inhibitor LY294002 results in diminished miR-20a and miR-31 production, while Erk inhibitor U0126 prevented VEGF-stimulated expression of miR-20a but not that of miR-31.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	microRNA 20a	Homo sapiens	208-215
28097093-5	2017	Treatment of human umbilical vein endothelial cells (HUVECs) with Akt inhibitor LY294002 results in diminished miR-20a and miR-31 production, while Erk inhibitor U0126 prevented VEGF-stimulated expression of miR-20a but not that of miR-31.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	microRNA 31	Homo sapiens	232-238
27863375-5	2016	The Bax/Bcl-2 ratio increased after 12 h of exposure to LY294002 or CQ.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	apoptosis regulator BAX	Heterocephalus glaber	4-7
27863375-5	2016	The Bax/Bcl-2 ratio increased after 12 h of exposure to LY294002 or CQ.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	apoptosis regulator Bcl-2	Heterocephalus glaber	8-13
27863375-7	2016	Furthermore, LY294002 or CQ treatment decreased caspase-3, p53, and HIF1-alpha levels, suggesting that serum starvation or H2O2 treatment increase autophagy and apoptosis in NMR skin fibroblasts by inhibiting the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	caspase-3	Heterocephalus glaber	48-57
27863375-7	2016	Furthermore, LY294002 or CQ treatment decreased caspase-3, p53, and HIF1-alpha levels, suggesting that serum starvation or H2O2 treatment increase autophagy and apoptosis in NMR skin fibroblasts by inhibiting the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	hypoxia-inducible factor 1-alpha	Heterocephalus glaber	68-78
27666600-5	2016	Knockdown of TS using small interfering RNA (siRNA) or inhibiting AKT activity with PI3K inhibitor LY294002 enhanced the cytotoxicity and cell growth inhibition of salinomycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	AKT serine/threonine kinase 1	Homo sapiens	66-69
27220977-9	2016	At the same time, retreatment with zinc protoporphyrin (ZnPP, a specific inhibitor of HO-1 enzymatic activity) or LY294002 (an inhibitor of Akt1) reversed the HO-1-induced changes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Rattus norvegicus	140-144
27738772-9	2016	Conversely, blocking Akt activation with the PI3K inhibitor LY294002 effectively suppressed the protective effects of DMY against I/R-induced injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	21-24
27994435-11	2016	In addition, the PI3K inhibitor LY294002 greatly decreased the p-PI3K, p-Akt, and VEGF protein levels, but PKR expression was unaffected, indicating that Akt was a downstream molecule of PKR that upregulated VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	vascular endothelial growth factor A	Macaca mulatta	82-86
27994435-11	2016	In addition, the PI3K inhibitor LY294002 greatly decreased the p-PI3K, p-Akt, and VEGF protein levels, but PKR expression was unaffected, indicating that Akt was a downstream molecule of PKR that upregulated VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	187-190
27994435-11	2016	In addition, the PI3K inhibitor LY294002 greatly decreased the p-PI3K, p-Akt, and VEGF protein levels, but PKR expression was unaffected, indicating that Akt was a downstream molecule of PKR that upregulated VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	vascular endothelial growth factor A	Macaca mulatta	208-212
27688248-8	2016	Neuroprotection of PF/beta-Ecd could be completely blocked by PKCdelta inhibitor rottlerin plus Akt specific inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
27220977-9	2016	At the same time, retreatment with zinc protoporphyrin (ZnPP, a specific inhibitor of HO-1 enzymatic activity) or LY294002 (an inhibitor of Akt1) reversed the HO-1-induced changes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	heme oxygenase 1	Rattus norvegicus	159-163
26970256-8	2016	Moreover, treatment of JAR and JEG3 cells with both apigenin and pharmacological inhibitors of PI3K/AKT (LY294002) and ERK1/2 (U0126) revealed synergistic anti-proliferative effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	100-103
26808296-5	2016	In addition, infection with H. pylori resulted in an increased intracellular level of Snail in gastric cancer cells, which was abrogated in the presence of U0126 and LY294002, inhibitors of MEK/Erk and PI3K/Akt pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	snail family transcriptional repressor 1	Homo sapiens	86-91
27798331-12	2016	The repressing effect of glycine on the expression of MuRF1, instead of atrogin-1, was abolished by LY294002 (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	tripartite motif containing 63	Homo sapiens	54-59
26687235-8	2016	Inhibition of the PI3K/Akt or Rac-1 by specific inhibitors LY294002 or si-Rac-1, respectively, partially reduces the protective effect of bFGF on BBB integrity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	23-26
26687235-8	2016	Inhibition of the PI3K/Akt or Rac-1 by specific inhibitors LY294002 or si-Rac-1, respectively, partially reduces the protective effect of bFGF on BBB integrity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	Rac family small GTPase 1	Homo sapiens	30-35
26687235-8	2016	Inhibition of the PI3K/Akt or Rac-1 by specific inhibitors LY294002 or si-Rac-1, respectively, partially reduces the protective effect of bFGF on BBB integrity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	fibroblast growth factor 2	Homo sapiens	138-142
26696494-6	2016	The beneficial effect of AST in reducing Abeta-induced cytotoxicity, apoptosis, and mitochondrial dysfunction in cortical cells were blocked by inhibition of phosphoinositide 3-kinase (PI3K)-dependent protein kinase B (PKB, as known as AKT) activation with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	257-265	amyloid beta precursor protein	Rattus norvegicus	41-46
26696494-6	2016	The beneficial effect of AST in reducing Abeta-induced cytotoxicity, apoptosis, and mitochondrial dysfunction in cortical cells were blocked by inhibition of phosphoinositide 3-kinase (PI3K)-dependent protein kinase B (PKB, as known as AKT) activation with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	257-265	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	158-183
27592408-9	2016	Moreover, the effect of Apelin-13 to up-regulate VEGF was suppressed by extracellular signal-regulated kinase (ERK) inhibitor U0126 and phosphatidylinositol 3"-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	vascular endothelial growth factor A	Homo sapiens	49-53
27592408-9	2016	Moreover, the effect of Apelin-13 to up-regulate VEGF was suppressed by extracellular signal-regulated kinase (ERK) inhibitor U0126 and phosphatidylinositol 3"-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	136-166
27167250-5	2016	This carbachol effect was almost completely blocked by the PI3K inhibitor LY294002, implying that PI3K is responsible for the Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	126-129
27167250-7	2016	This carbachol-stimulated S6K1 activation was abrogated by LY294002 or the mTORC1 inhibitor rapamycin, supporting the notion that mAChRs mediate S6K1 activation via the PI3K-Akt-mTORC1 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	ribosomal protein S6 kinase B1	Homo sapiens	26-30
27167250-7	2016	This carbachol-stimulated S6K1 activation was abrogated by LY294002 or the mTORC1 inhibitor rapamycin, supporting the notion that mAChRs mediate S6K1 activation via the PI3K-Akt-mTORC1 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	ribosomal protein S6 kinase B1	Homo sapiens	145-149
27167250-7	2016	This carbachol-stimulated S6K1 activation was abrogated by LY294002 or the mTORC1 inhibitor rapamycin, supporting the notion that mAChRs mediate S6K1 activation via the PI3K-Akt-mTORC1 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	174-177
27167250-7	2016	This carbachol-stimulated S6K1 activation was abrogated by LY294002 or the mTORC1 inhibitor rapamycin, supporting the notion that mAChRs mediate S6K1 activation via the PI3K-Akt-mTORC1 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	CREB regulated transcription coactivator 1	Mus musculus	178-184
26808296-5	2016	In addition, infection with H. pylori resulted in an increased intracellular level of Snail in gastric cancer cells, which was abrogated in the presence of U0126 and LY294002, inhibitors of MEK/Erk and PI3K/Akt pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	mitogen-activated protein kinase 1	Homo sapiens	194-197
27740938-10	2016	LY294002 attenuated the 7-KC-induced apoptosis and IL-8 mRNA expression of endothelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
27840989-8	2016	The protein levels of phosphorylated (p) AKT and pGSK-3beta were decreased following pretreatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	AKT serine/threonine kinase 1	Homo sapiens	41-44
27777063-8	2016	Moreover, either LY294002 or TFP abolished the liraglutide-induced upregulation of GTPCH1 and eNOS protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	GTP cyclohydrolase 1	Homo sapiens	83-89
27777063-8	2016	Moreover, either LY294002 or TFP abolished the liraglutide-induced upregulation of GTPCH1 and eNOS protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	nitric oxide synthase 3	Homo sapiens	94-98
26935342-10	2016	The above protective effects were attenuated by coculturing with Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
27598237-2	2016	Compared with positive control LY294002, a PI3K inhibitor, derivatives 5a, 19a, 20a, 19g, 20f, 5c, 12e and 12f exhibited significant inhibitory effects against cancer cell migration induced by chemokine epidermal growth factor (EGF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	epidermal growth factor	Homo sapiens	203-226
27598237-2	2016	Compared with positive control LY294002, a PI3K inhibitor, derivatives 5a, 19a, 20a, 19g, 20f, 5c, 12e and 12f exhibited significant inhibitory effects against cancer cell migration induced by chemokine epidermal growth factor (EGF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	epidermal growth factor	Homo sapiens	228-231
27748934-8	2016	Treatment with PI3K inhibitor LY294002 augmented the effects of salidroside on the expression of Akt and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	97-100
27748934-8	2016	Treatment with PI3K inhibitor LY294002 augmented the effects of salidroside on the expression of Akt and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	mechanistic target of rapamycin kinase	Homo sapiens	105-109
27904664-4	2016	The PI3K and PKG inhibitors LY294002 and KT5823 inhibited the effect of TUDCA on mPTP opening, suggesting the involvement of PI3K/Akt and PKG signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	130-133
27904664-7	2016	TUDCA-induced increases in Akt and GSK-3beta phosphorylation were inhibited by LY294002, whereas KT5823 suppressed TUDCA-induced increases in VASP and GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Rattus norvegicus	27-30
27904664-7	2016	TUDCA-induced increases in Akt and GSK-3beta phosphorylation were inhibited by LY294002, whereas KT5823 suppressed TUDCA-induced increases in VASP and GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	glycogen synthase kinase 3 beta	Rattus norvegicus	35-44
27895401-3	2016	Using HER2-positve GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	erb-b2 receptor tyrosine kinase 2	Homo sapiens	6-10
27895401-3	2016	Using HER2-positve GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	erb-b2 receptor tyrosine kinase 2	Homo sapiens	54-58
27895401-3	2016	Using HER2-positve GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	mitogen-activated protein kinase 8	Homo sapiens	127-130
27895401-3	2016	Using HER2-positve GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	AKT serine/threonine kinase 1	Homo sapiens	135-138
27619643-5	2016	After CD147 stealth siRNA transfection treatment, the production of VEGF was reduced depended on the inhibition efficiency of CD147 siRNAs.The special signaling pathway inhibitors LY294002, SP600125, SB203580 and U0126 were added to cultures respectively and the results showed LY294002 dose-dependently inhibited the expression of VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	278-286	basigin (Ok blood group)	Homo sapiens	6-11
27811956-5	2016	MDA-MB-468 breast and HCT8 colorectal cancer cells were treated with inhibitors including LY294002, MK2206, rapamycin, AZD8055 targeting key kinases in/associated with Akt pathway and the consistency of changes in 31P-NMR-detecatable metabolite content of tumour cells was examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 1	Homo sapiens	168-171
27619643-5	2016	After CD147 stealth siRNA transfection treatment, the production of VEGF was reduced depended on the inhibition efficiency of CD147 siRNAs.The special signaling pathway inhibitors LY294002, SP600125, SB203580 and U0126 were added to cultures respectively and the results showed LY294002 dose-dependently inhibited the expression of VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	basigin (Ok blood group)	Homo sapiens	6-11
27619643-5	2016	After CD147 stealth siRNA transfection treatment, the production of VEGF was reduced depended on the inhibition efficiency of CD147 siRNAs.The special signaling pathway inhibitors LY294002, SP600125, SB203580 and U0126 were added to cultures respectively and the results showed LY294002 dose-dependently inhibited the expression of VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	278-286	vascular endothelial growth factor A	Homo sapiens	68-72
27619643-5	2016	After CD147 stealth siRNA transfection treatment, the production of VEGF was reduced depended on the inhibition efficiency of CD147 siRNAs.The special signaling pathway inhibitors LY294002, SP600125, SB203580 and U0126 were added to cultures respectively and the results showed LY294002 dose-dependently inhibited the expression of VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	vascular endothelial growth factor A	Homo sapiens	68-72
27619643-6	2016	The reduction of phospho-Akt was observed in both LY294002 and siRNA groups, suggested that the phosphatidylinositol 3-kinase/Akt pathway may be the probable signaling pathway underlying CD147 induced up-regulation of VEGF in U937-derived foam cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	25-28
27619643-6	2016	The reduction of phospho-Akt was observed in both LY294002 and siRNA groups, suggested that the phosphatidylinositol 3-kinase/Akt pathway may be the probable signaling pathway underlying CD147 induced up-regulation of VEGF in U937-derived foam cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	126-129
27619643-6	2016	The reduction of phospho-Akt was observed in both LY294002 and siRNA groups, suggested that the phosphatidylinositol 3-kinase/Akt pathway may be the probable signaling pathway underlying CD147 induced up-regulation of VEGF in U937-derived foam cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	basigin (Ok blood group)	Homo sapiens	187-192
27619643-6	2016	The reduction of phospho-Akt was observed in both LY294002 and siRNA groups, suggested that the phosphatidylinositol 3-kinase/Akt pathway may be the probable signaling pathway underlying CD147 induced up-regulation of VEGF in U937-derived foam cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	vascular endothelial growth factor A	Homo sapiens	218-222
27421985-10	2016	Besides, we found evidence that LY294002 directly inhibits mTORC1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	CREB regulated transcription coactivator 1	Mus musculus	59-65
27793908-0	2016	Co-treatment of LY294002 or MK-2206 with AZD5363 Attenuates AZD5363-induced Increase in the Level of Phosphorylated AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	116-119
27421985-3	2016	Previous studies using the broad PI3K inhibitor, LY294002 allowed to propose that PI3 kinase&gt;Akt pathway is a key element in the determination of axonal polarity in hippocampal neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	96-99
27666419-4	2016	The effects of inhibiting phosphoinositide 3-kinase (PI3K)/Akt signaling using LY294002 were investigated in hypoxic HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	59-62
26942921-9	2016	The inhibitor of Akt (LY 294002) or ERK1/2 (PD98059) can inhibit VEGF alone and cooperatively reinforce the suppression effects of VPA on HIF-1alpha and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-31	AKT serine/threonine kinase 1	Homo sapiens	17-20
26942921-9	2016	The inhibitor of Akt (LY 294002) or ERK1/2 (PD98059) can inhibit VEGF alone and cooperatively reinforce the suppression effects of VPA on HIF-1alpha and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-31	vascular endothelial growth factor A	Homo sapiens	65-69
26942921-9	2016	The inhibitor of Akt (LY 294002) or ERK1/2 (PD98059) can inhibit VEGF alone and cooperatively reinforce the suppression effects of VPA on HIF-1alpha and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-148
26942921-9	2016	The inhibitor of Akt (LY 294002) or ERK1/2 (PD98059) can inhibit VEGF alone and cooperatively reinforce the suppression effects of VPA on HIF-1alpha and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-31	vascular endothelial growth factor A	Homo sapiens	153-157
27496136-5	2016	We demonstrate that the active moiety of the SF1126 prodrug LY294002 binds to and blocks BRD4 interaction with the acetylated histone-H4 chromatin mark protein and displaced BRD4 coactivator protein from the transcriptional start site of MYC in Huh7 and SK-Hep1 HCC cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	bromodomain containing 4	Homo sapiens	89-93
27496136-5	2016	We demonstrate that the active moiety of the SF1126 prodrug LY294002 binds to and blocks BRD4 interaction with the acetylated histone-H4 chromatin mark protein and displaced BRD4 coactivator protein from the transcriptional start site of MYC in Huh7 and SK-Hep1 HCC cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	bromodomain containing 4	Homo sapiens	174-178
27496136-5	2016	We demonstrate that the active moiety of the SF1126 prodrug LY294002 binds to and blocks BRD4 interaction with the acetylated histone-H4 chromatin mark protein and displaced BRD4 coactivator protein from the transcriptional start site of MYC in Huh7 and SK-Hep1 HCC cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	238-241
27496136-5	2016	We demonstrate that the active moiety of the SF1126 prodrug LY294002 binds to and blocks BRD4 interaction with the acetylated histone-H4 chromatin mark protein and displaced BRD4 coactivator protein from the transcriptional start site of MYC in Huh7 and SK-Hep1 HCC cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	MIR7-3 host gene	Homo sapiens	245-249
27496136-5	2016	We demonstrate that the active moiety of the SF1126 prodrug LY294002 binds to and blocks BRD4 interaction with the acetylated histone-H4 chromatin mark protein and displaced BRD4 coactivator protein from the transcriptional start site of MYC in Huh7 and SK-Hep1 HCC cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	DNL-type zinc finger	Homo sapiens	257-261
27806094-7	2016	Similarly, the specific PI3K inhibitor LY294002, suppressed AKT and ERK phosphorylation showing that VEGF feedback is PI3K-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	60-63
27806094-7	2016	Similarly, the specific PI3K inhibitor LY294002, suppressed AKT and ERK phosphorylation showing that VEGF feedback is PI3K-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	mitogen-activated protein kinase 1	Homo sapiens	68-71
27806094-7	2016	Similarly, the specific PI3K inhibitor LY294002, suppressed AKT and ERK phosphorylation showing that VEGF feedback is PI3K-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	vascular endothelial growth factor A	Homo sapiens	101-105
27302964-4	2016	This insulin-stimulated activities were abolished by the PI3K and MEK1 inhibitors LY294002 and PD98059, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	mitogen activated protein kinase kinase 1	Rattus norvegicus	66-70
27666419-9	2016	Furthermore, LY294002 reduced the mRNA and protein expression levels of CCN1 in the hypoxic cells (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cellular communication network factor 1	Homo sapiens	72-76
27699665-10	2016	Importantly, Adr resistance induced by miR-222 overexpression through PTEN/Akt/p27 was completely blocked by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	microRNA 222	Homo sapiens	39-46
27580711-8	2016	LY294002, the specific inhibitor of PI3-K, significantly abrogated the protein expression of up-regulated phosphorylated Akt offered by Z-LIG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	121-124
27580711-8	2016	LY294002, the specific inhibitor of PI3-K, significantly abrogated the protein expression of up-regulated phosphorylated Akt offered by Z-LIG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ubiquitin conjugating enzyme E2 K	Homo sapiens	138-141
28123432-5	2016	Pathway inhibitor tests showed that the protective effect of NGF was completely reversed by LY294002 (PI3K inhibitor), Akt VIII inhibitor, and PD98059 (ERK1/2 inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	nerve growth factor	Mus musculus	61-64
27664319-5	2016	These pro-inflammatory responses were inhibited by the Akt blocker, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Rattus norvegicus	55-58
27664319-8	2016	Besides, Akt blocker LY294002 also obviously attenuated NF-kB activation and transnuclear induced by Arsenic trioxide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Rattus norvegicus	9-12
27664319-8	2016	Besides, Akt blocker LY294002 also obviously attenuated NF-kB activation and transnuclear induced by Arsenic trioxide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	56-61
27699665-10	2016	Importantly, Adr resistance induced by miR-222 overexpression through PTEN/Akt/p27 was completely blocked by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	phosphatase and tensin homolog	Homo sapiens	70-74
27699665-10	2016	Importantly, Adr resistance induced by miR-222 overexpression through PTEN/Akt/p27 was completely blocked by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	AKT serine/threonine kinase 1	Homo sapiens	75-78
27699665-10	2016	Importantly, Adr resistance induced by miR-222 overexpression through PTEN/Akt/p27 was completely blocked by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	zinc ribbon domain containing 2	Homo sapiens	79-82
27699665-10	2016	Importantly, Adr resistance induced by miR-222 overexpression through PTEN/Akt/p27 was completely blocked by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	AKT serine/threonine kinase 1	Homo sapiens	122-125
27774951-10	2016	Moreover, LY294002, an inhibitor of PI3K/Akt, significantly suppressed the biological effect activated by LIPUS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	41-44
27779177-4	2016	In addition, mouse neuroblastoma NG108-15 cells were treated ethanol for 3 days and subsequently treated with AKT inhibitor LY294002 for 2-12 h. The in vitro kinase assay was performed for determining mTOR activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	thymoma viral proto-oncogene 1	Mus musculus	110-113
27602956-5	2016	More importantly, we found that uPAR expression is associated with sensitivity to cisplatin in MM through the PI3K/AKT pathway, which was demonstrated with specific inhibitors, LY294002 and Akti-1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	plasminogen activator, urokinase receptor	Homo sapiens	32-36
27602956-5	2016	More importantly, we found that uPAR expression is associated with sensitivity to cisplatin in MM through the PI3K/AKT pathway, which was demonstrated with specific inhibitors, LY294002 and Akti-1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	AKT serine/threonine kinase 1	Homo sapiens	115-118
27779177-4	2016	In addition, mouse neuroblastoma NG108-15 cells were treated ethanol for 3 days and subsequently treated with AKT inhibitor LY294002 for 2-12 h. The in vitro kinase assay was performed for determining mTOR activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	mechanistic target of rapamycin kinase	Mus musculus	201-205
27779177-10	2016	Compared with NG108-15 cells treated without both ethanol and LY294002, ethanol increased the expression level of P-AKT, P-S6K, and P-S6, whereas LY294002 had opposite effects on expression levels of these proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	thymoma viral proto-oncogene 1	Mus musculus	116-119
27424778-4	2016	WIN and URB treatment improved learning and memory performance, effects that were abolished by co-administration of the PI3K/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Rattus norvegicus	125-128
27756897-7	2016	In addition, while ASA VI enhanced the expression of ALP, OCN, Col 1 and RUNX2, treatment with LY294002 reduced all of these osteogenic effects and reduced the p-AKT levels induced by ASA VI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	RUNX family transcription factor 2	Rattus norvegicus	73-78
27781258-5	2016	The LY294002, BEZ235 and Everolimus which are aimed at PI3K/mTOR signaling pathway have shown great promise.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	55-64
27769315-8	2016	An antibody against the leptin receptor (anti-ObR) and the PI3K/AKT signaling pathway inhibitor LY294002 significantly abolished leptin-induced PKM2 expression and EMT-associated marker expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	pyruvate kinase M1/2	Homo sapiens	144-148
27784964-8	2016	The expression of glucose glycolysis-related proteins and ECM components decreased remarkably when the PI3K/Akt signaling was blocked by Ly294002 in the activated HSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	thymoma viral proto-oncogene 1	Mus musculus	108-111
27329155-5	2016	We describe a stimulatory effect of PGD2 on lactate dehydrogenase (LDH) expression via DP1/DP2 receptors, which is prevented by the antioxidant N-acetyl-L-cysteine and the PI3K/Akt pathway inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-208	transcription factor Dp 1	Mus musculus	87-104
27639645-6	2016	Moreover, Western blot analysis showed that the decreased PI3K and AKT phosphorylation, increased the epithelial maker E-cadherin, and upregulation level of RARbeta while decreased the mesenchymal markers N-cadherin and downregulation level of RARalpha by incubation with LY294002 in mouse melanoma B16 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	272-280	thymoma viral proto-oncogene 1	Mus musculus	67-70
27639645-6	2016	Moreover, Western blot analysis showed that the decreased PI3K and AKT phosphorylation, increased the epithelial maker E-cadherin, and upregulation level of RARbeta while decreased the mesenchymal markers N-cadherin and downregulation level of RARalpha by incubation with LY294002 in mouse melanoma B16 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	272-280	retinoic acid receptor, beta	Mus musculus	157-164
27752996-11	2016	Pre-treatment with any of the inhibitors for PI3K (LY294002), MAPK (PD98059), Akt (perifosine), or mTOR (rapamycin) blocked the BDNF/TrkB-induced increases of cell migration and invasion in TB3 cells, and also blocked the BDNF/TrkB-induced expressions of P-Akt, P-Erk, and P-mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	brain derived neurotrophic factor	Mus musculus	128-132
27777878-8	2016	Akt inhibitors, e.g., MK-2206 and perifosine, or PI3K modulators, e.g., LY294002 and Wortmannin, have shown some promising results in favor of sensitizing the cancer cells to the therapy in vitro and in vivo, which have provided the rationale for incorporation of these novel agents into multimodality treatment of different malignancies.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	0-3
27614310-6	2016	Akt inhibitors (LY294002, perifosine and MK-2206) blocked SC79-induced Akt activation and abolished its anti-Dex actions in osteoblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	thymoma viral proto-oncogene 1	Mus musculus	0-3
27614310-6	2016	Akt inhibitors (LY294002, perifosine and MK-2206) blocked SC79-induced Akt activation and abolished its anti-Dex actions in osteoblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	thymoma viral proto-oncogene 1	Mus musculus	71-74
26956696-8	2016	In co-treatment Zn with PI3K/Akt/GSK-3beta signaling pathway, inhibitor LY294002 prevented HG/hypoxic-induced HIF-1alpha increase and EMT changes, suggesting that Zn may mediate HG/hypoxic-induced EMT through PI3K/Akt/GSK-3beta pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	glycogen synthase kinase 3 beta	Mus musculus	33-42
27321870-9	2016	Blockage of Akt signaling by Akt inhibitor AZD5363 or PI3K inhibitor LY294002, led to an inhibitory effect of WISP1-induced proliferation and migration in human VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	12-15
27321870-9	2016	Blockage of Akt signaling by Akt inhibitor AZD5363 or PI3K inhibitor LY294002, led to an inhibitory effect of WISP1-induced proliferation and migration in human VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	cellular communication network factor 4	Homo sapiens	110-115
27038254-9	2016	Both inhibitors of ERK1/2 (PD98059) and Akt (LY294002) can attenuate BPA-induced ERRgamma expression and cell invasion of MDA-MB-231 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	40-43
27038254-9	2016	Both inhibitors of ERK1/2 (PD98059) and Akt (LY294002) can attenuate BPA-induced ERRgamma expression and cell invasion of MDA-MB-231 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	estrogen related receptor gamma	Homo sapiens	81-89
26956696-8	2016	In co-treatment Zn with PI3K/Akt/GSK-3beta signaling pathway, inhibitor LY294002 prevented HG/hypoxic-induced HIF-1alpha increase and EMT changes, suggesting that Zn may mediate HG/hypoxic-induced EMT through PI3K/Akt/GSK-3beta pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	thymoma viral proto-oncogene 1	Mus musculus	214-217
26956696-8	2016	In co-treatment Zn with PI3K/Akt/GSK-3beta signaling pathway, inhibitor LY294002 prevented HG/hypoxic-induced HIF-1alpha increase and EMT changes, suggesting that Zn may mediate HG/hypoxic-induced EMT through PI3K/Akt/GSK-3beta pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	glycogen synthase kinase 3 beta	Mus musculus	218-227
27511131-7	2016	Inhibition of Akt activation with LY294002 or by Rictor knockdown did not block the protective effect of IGF-1, while inhibition of MEK activity with PD98059 prevented Bim phosphorylation and blocked IGF-1 protection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
27190251-10	2016	LY294002 (10 micromol/L), a phosphatidyl-inositol 3 kinase inhibitor (PI3K), reversed the effects of grape powder extracted polyphenols on cellular lipid content and glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	28-68
27497988-9	2016	Importantly, blockade of Akt/mTOR signaling pathway with LY294002, a specific PI3K inhibitor, replicated these effects of thioredoxin-interacting protein silencing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	thymoma viral proto-oncogene 1	Mus musculus	25-28
27473926-10	2016	The effects of visfatin on proliferation and apoptosis were abrogated by treatment with the PI3K inhibitor LY294002 and MEK inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	nicotinamide phosphoribosyltransferase	Homo sapiens	15-23
27426724-6	2016	Activation of TLR4 signaling by LPS in PANC-1 cells resulted in increased VEGF and phosphorylation of AKT, which were abolished by TLR4 silencing with siRNA and PI3K/AKT signaling inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	toll like receptor 4	Homo sapiens	14-18
27426724-6	2016	Activation of TLR4 signaling by LPS in PANC-1 cells resulted in increased VEGF and phosphorylation of AKT, which were abolished by TLR4 silencing with siRNA and PI3K/AKT signaling inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	vascular endothelial growth factor A	Homo sapiens	74-78
27426724-6	2016	Activation of TLR4 signaling by LPS in PANC-1 cells resulted in increased VEGF and phosphorylation of AKT, which were abolished by TLR4 silencing with siRNA and PI3K/AKT signaling inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	AKT serine/threonine kinase 1	Homo sapiens	102-105
27426724-6	2016	Activation of TLR4 signaling by LPS in PANC-1 cells resulted in increased VEGF and phosphorylation of AKT, which were abolished by TLR4 silencing with siRNA and PI3K/AKT signaling inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	toll like receptor 4	Homo sapiens	131-135
27426724-6	2016	Activation of TLR4 signaling by LPS in PANC-1 cells resulted in increased VEGF and phosphorylation of AKT, which were abolished by TLR4 silencing with siRNA and PI3K/AKT signaling inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	AKT serine/threonine kinase 1	Homo sapiens	166-169
27604954-11	2016	The effects of nm23 siRNA (si-nm23) and the PI3K inhibitor LY294002 on the downstream effects of nm23 on the PI3K-Akt-mTOR signaling pathway were estimated by western blot.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	114-117
27604954-11	2016	The effects of nm23 siRNA (si-nm23) and the PI3K inhibitor LY294002 on the downstream effects of nm23 on the PI3K-Akt-mTOR signaling pathway were estimated by western blot.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	mechanistic target of rapamycin kinase	Homo sapiens	118-122
27590856-8	2016	LY294002, a PI3-K inhibitor, further reduced CD2AP expression and increased podocyte apoptosis, which was augmented by siRNA for CD2AP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CD2-associated protein	Mus musculus	45-50
27497988-9	2016	Importantly, blockade of Akt/mTOR signaling pathway with LY294002, a specific PI3K inhibitor, replicated these effects of thioredoxin-interacting protein silencing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	mechanistic target of rapamycin kinase	Mus musculus	29-33
27590856-8	2016	LY294002, a PI3-K inhibitor, further reduced CD2AP expression and increased podocyte apoptosis, which was augmented by siRNA for CD2AP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CD2-associated protein	Mus musculus	129-134
27497988-9	2016	Importantly, blockade of Akt/mTOR signaling pathway with LY294002, a specific PI3K inhibitor, replicated these effects of thioredoxin-interacting protein silencing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	thioredoxin interacting protein	Mus musculus	122-153
27296115-5	2016	Western Blot analysis detected both TrkB receptor isoforms in the synaptosomes but the BDNF effect seems to be mediated by TrkB-FL since: 1) the tyrosine kinase inhibitor, k252a, prevented the effect of BDNF, and 2) the effect of BDNF was lost in the presence of specific inhibitors of TrkB signalling pathways, namely U73122, LY294002 and U0126 (inhibitors of PLC, Akt and MAPK pathways, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	327-335	brain-derived neurotrophic factor	Rattus norvegicus	87-91
27599586-9	2016	The phosphoinositide 3-kinase (PI3K)/AKT pathway inhibitor LY294002 significantly suppressed IL-21-induced osteoclastogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	4-29
27599586-9	2016	The phosphoinositide 3-kinase (PI3K)/AKT pathway inhibitor LY294002 significantly suppressed IL-21-induced osteoclastogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	thymoma viral proto-oncogene 1	Mus musculus	37-40
27599586-9	2016	The phosphoinositide 3-kinase (PI3K)/AKT pathway inhibitor LY294002 significantly suppressed IL-21-induced osteoclastogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	interleukin 21	Mus musculus	93-98
27580020-4	2016	Furthermore, phosphorylation of protein kinase B (AKT) and glycogen synthase kinase-3beta (GSK3beta) in model cells was recovered after treated with MAE, leading to an up-regulation of glycogen synthase 2 (GYS2), and this effect was blocked by the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	295-303	AKT serine/threonine kinase 1	Homo sapiens	50-53
27580020-4	2016	Furthermore, phosphorylation of protein kinase B (AKT) and glycogen synthase kinase-3beta (GSK3beta) in model cells was recovered after treated with MAE, leading to an up-regulation of glycogen synthase 2 (GYS2), and this effect was blocked by the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	295-303	glycogen synthase kinase 3 beta	Homo sapiens	59-89
27580020-4	2016	Furthermore, phosphorylation of protein kinase B (AKT) and glycogen synthase kinase-3beta (GSK3beta) in model cells was recovered after treated with MAE, leading to an up-regulation of glycogen synthase 2 (GYS2), and this effect was blocked by the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	295-303	glycogen synthase kinase 3 beta	Homo sapiens	91-99
27580020-4	2016	Furthermore, phosphorylation of protein kinase B (AKT) and glycogen synthase kinase-3beta (GSK3beta) in model cells was recovered after treated with MAE, leading to an up-regulation of glycogen synthase 2 (GYS2), and this effect was blocked by the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	295-303	glycogen synthase 2	Homo sapiens	185-204
27380038-5	2016	LY294002 was injected intracerebroventricularly to inhibit the activation of PI3K/Akt signaling pathway selectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	82-85
27380038-11	2016	5-LOX inhibitor zileuton significantly reduces neurological deficit scores, cerebral infarct volume, cerebral water content, ischemic neuronal injury and the enzymatic activity of MPO, all of which were abolished by LY294002 administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	216-224	myeloperoxidase	Rattus norvegicus	180-183
27380038-12	2016	Zileuton significantly up-regulates the expression of p-Akt, which was inhibited by LY294002 administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Rattus norvegicus	56-59
27380038-13	2016	Zileuton significantly down-regulates the over-expression of NF-kappaB p65 and COX-2, and attenuates the release of TNF-alpha, all of which were disminished by LY294002 administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	79-84
27380038-13	2016	Zileuton significantly down-regulates the over-expression of NF-kappaB p65 and COX-2, and attenuates the release of TNF-alpha, all of which were disminished by LY294002 administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	tumor necrosis factor	Rattus norvegicus	116-125
27291828-10	2016	Furthermore, administration of the PI3K inhibitor LY294002 that blocks GSK-3beta phosphorylation, prevented the procognitive effects of both drugs in normal mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	glycogen synthase kinase 3 beta	Mus musculus	71-80
27498673-9	2016	Furthermore, a specific phosphatidylinositol 3 kinase (PI3K) inhibitor, LY294002, enhanced the pro-apoptotic and anti-invasive effects induced by oleuropein, which suggested that oleuropein suppressed the growth and invasion of glioma cells via inhibition of AKT activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	259-262
27371897-9	2016	Addition of LY294002 to the reaction medium caused a near-complete inhibition of Akt-phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	81-84
28116426-9	2016	LY294002 blocked partially the inhibitory roles of Egr-1 in the secretion and expression of inflammatory cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	early growth response 1	Homo sapiens	51-56
27641443-8	2016	Recruitment of ERalpha and PR to chromatin and subsequent PR mRNA induction were dependent upon rapid activation of MAPK/ERK and AKT; inhibition of these kinase pathways via U0126 or LY294002 blocked these events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	mitogen-activated protein kinase 1	Homo sapiens	121-124
27641443-8	2016	Recruitment of ERalpha and PR to chromatin and subsequent PR mRNA induction were dependent upon rapid activation of MAPK/ERK and AKT; inhibition of these kinase pathways via U0126 or LY294002 blocked these events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	AKT serine/threonine kinase 1	Homo sapiens	129-132
27572688-9	2016	Additionally, inhibition of AKT by LY294002 abrogated CXCR7-induced angiogenic capacity in HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	28-31
27572688-9	2016	Additionally, inhibition of AKT by LY294002 abrogated CXCR7-induced angiogenic capacity in HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	atypical chemokine receptor 3	Homo sapiens	54-59
27372924-13	2016	These results demonstrated that LY294002 inhibited the effect of H2S on decreasing the BACE1 and PS1, reducing the level of Abeta and improving memory impairment in APP/PS1 transgenic mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	beta-site APP cleaving enzyme 1	Mus musculus	87-92
27372924-13	2016	These results demonstrated that LY294002 inhibited the effect of H2S on decreasing the BACE1 and PS1, reducing the level of Abeta and improving memory impairment in APP/PS1 transgenic mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	presenilin 1	Mus musculus	97-100
27372924-13	2016	These results demonstrated that LY294002 inhibited the effect of H2S on decreasing the BACE1 and PS1, reducing the level of Abeta and improving memory impairment in APP/PS1 transgenic mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	amyloid beta (A4) precursor protein	Mus musculus	124-129
27372924-13	2016	These results demonstrated that LY294002 inhibited the effect of H2S on decreasing the BACE1 and PS1, reducing the level of Abeta and improving memory impairment in APP/PS1 transgenic mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	presenilin 1	Mus musculus	169-172
29441927-4	2016	A PI3K/Akt inhibitor LY294002 was used to block the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	7-10
29441927-4	2016	A PI3K/Akt inhibitor LY294002 was used to block the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	57-60
27641443-8	2016	Recruitment of ERalpha and PR to chromatin and subsequent PR mRNA induction were dependent upon rapid activation of MAPK/ERK and AKT; inhibition of these kinase pathways via U0126 or LY294002 blocked these events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	estrogen receptor 1	Homo sapiens	15-22
27641443-8	2016	Recruitment of ERalpha and PR to chromatin and subsequent PR mRNA induction were dependent upon rapid activation of MAPK/ERK and AKT; inhibition of these kinase pathways via U0126 or LY294002 blocked these events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	progesterone receptor	Homo sapiens	27-29
27641443-8	2016	Recruitment of ERalpha and PR to chromatin and subsequent PR mRNA induction were dependent upon rapid activation of MAPK/ERK and AKT; inhibition of these kinase pathways via U0126 or LY294002 blocked these events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	progesterone receptor	Homo sapiens	58-60
27641443-8	2016	Recruitment of ERalpha and PR to chromatin and subsequent PR mRNA induction were dependent upon rapid activation of MAPK/ERK and AKT; inhibition of these kinase pathways via U0126 or LY294002 blocked these events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	mitogen-activated protein kinase 1	Homo sapiens	116-120
27586274-4	2016	The autophagy inhibitors 3-methyladenine and LY294002 enhanced MiTMAB-induced apoptotic sub-G1 peak, BAG3 and Mcl-1 down-regulation, Bak activation, Deltapsim loss, and caspase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	BAG cochaperone 3	Homo sapiens	101-105
27586274-4	2016	The autophagy inhibitors 3-methyladenine and LY294002 enhanced MiTMAB-induced apoptotic sub-G1 peak, BAG3 and Mcl-1 down-regulation, Bak activation, Deltapsim loss, and caspase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	110-115
27296115-5	2016	Western Blot analysis detected both TrkB receptor isoforms in the synaptosomes but the BDNF effect seems to be mediated by TrkB-FL since: 1) the tyrosine kinase inhibitor, k252a, prevented the effect of BDNF, and 2) the effect of BDNF was lost in the presence of specific inhibitors of TrkB signalling pathways, namely U73122, LY294002 and U0126 (inhibitors of PLC, Akt and MAPK pathways, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	327-335	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	123-127
27296115-5	2016	Western Blot analysis detected both TrkB receptor isoforms in the synaptosomes but the BDNF effect seems to be mediated by TrkB-FL since: 1) the tyrosine kinase inhibitor, k252a, prevented the effect of BDNF, and 2) the effect of BDNF was lost in the presence of specific inhibitors of TrkB signalling pathways, namely U73122, LY294002 and U0126 (inhibitors of PLC, Akt and MAPK pathways, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	327-335	brain-derived neurotrophic factor	Rattus norvegicus	203-207
27755950-10	2016	Matrine pretreatment suppressed SAH-induced MMP-9 expression, which could be partially blocked by HO-1 inhibitor Sn-protoporphyrin IX (SnPP IX) but promoted by phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	matrix metallopeptidase 9	Rattus norvegicus	44-49
27296115-5	2016	Western Blot analysis detected both TrkB receptor isoforms in the synaptosomes but the BDNF effect seems to be mediated by TrkB-FL since: 1) the tyrosine kinase inhibitor, k252a, prevented the effect of BDNF, and 2) the effect of BDNF was lost in the presence of specific inhibitors of TrkB signalling pathways, namely U73122, LY294002 and U0126 (inhibitors of PLC, Akt and MAPK pathways, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	327-335	brain-derived neurotrophic factor	Rattus norvegicus	203-207
27296115-5	2016	Western Blot analysis detected both TrkB receptor isoforms in the synaptosomes but the BDNF effect seems to be mediated by TrkB-FL since: 1) the tyrosine kinase inhibitor, k252a, prevented the effect of BDNF, and 2) the effect of BDNF was lost in the presence of specific inhibitors of TrkB signalling pathways, namely U73122, LY294002 and U0126 (inhibitors of PLC, Akt and MAPK pathways, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	327-335	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	123-127
27553280-7	2016	LY294002 and the mammalian target of rapamycin (mTOR) inhibitor rapamycin repressed the enhancing effects of Hyp-Gly on MyHC and tropomyosin expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	myosin heavy chain 6	Homo sapiens	120-124
27671604-6	2016	As2O3 activated the AKT/GSK-3beta/Snail signaling pathway, and blocking this pathway with PI3K inhibitor (LY294002) abolished EndMT in As2O3-treated endothelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	AKT serine/threonine kinase 1	Rattus norvegicus	20-23
27671604-6	2016	As2O3 activated the AKT/GSK-3beta/Snail signaling pathway, and blocking this pathway with PI3K inhibitor (LY294002) abolished EndMT in As2O3-treated endothelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	glycogen synthase kinase 3 beta	Rattus norvegicus	24-33
27685463-8	2016	LY294002, a specific PI3K/Akt inhibitor, abolished agmatine-induced HO-1 up-regulation and ROS suppression significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	26-29
28955964-10	2016	All of the above mentioned ARA-S-induced effects were reduced by the treatment with LY294002 (inhibitor of PI3/Akt kinase), except MAPK kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	peptidase inhibitor 3	Homo sapiens	107-110
28955964-10	2016	All of the above mentioned ARA-S-induced effects were reduced by the treatment with LY294002 (inhibitor of PI3/Akt kinase), except MAPK kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Homo sapiens	111-114
27557491-7	2016	Inversely, inhibition of AKT by LY294002 treatment markedly enhanced Sal B-induced autophagy and cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	25-28
27457802-6	2016	LY294002 (AKT inhibitor) inhibited melatonin-mediated proliferation in PC12 cells and did not affect melatonin-induced neural differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	10-13
27450812-11	2016	Conversely, treatment with LY294002 (a selective inhibitor of Akt1) reversed the effects of quercetin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	thymoma viral proto-oncogene 1	Mus musculus	62-66
27632174-7	2016	Pretreatment with PI3K (LY294002), p38 MAPK (SB203580) and MEK (U0126) inhibitors completely inhibited Ang1-mediated increase of MIP-1beta intracellular and extracellular protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	angiopoietin 1	Homo sapiens	103-107
27632174-7	2016	Pretreatment with PI3K (LY294002), p38 MAPK (SB203580) and MEK (U0126) inhibitors completely inhibited Ang1-mediated increase of MIP-1beta intracellular and extracellular protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	C-C motif chemokine ligand 4	Homo sapiens	129-138
27494877-8	2016	Inhibition of pAKT by LY294002 or inhibition of pMET by PHA-665752 significantly inhibited the expression of FOXM1 in lung adenocarcinoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	forkhead box M1	Homo sapiens	109-114
27018134-9	2016	On inhibiting Akt (by PI3K inhibitor, LY294002) and ERK1/2 (by ERK1/2 inhibitor, PD98059) specifically, caspase 3 got activated abolishing mangiferin"s protective role on As-induced hepatotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	14-17
27018134-9	2016	On inhibiting Akt (by PI3K inhibitor, LY294002) and ERK1/2 (by ERK1/2 inhibitor, PD98059) specifically, caspase 3 got activated abolishing mangiferin"s protective role on As-induced hepatotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	caspase 3	Homo sapiens	104-113
27624978-8	2016	In addition, overexpressing ITGA6 promoted radiation resistance in cells, and this effect was neutralized by the PI3K inhibitor LY294002 and MEK inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	integrin subunit alpha 6	Homo sapiens	28-33
27698937-7	2016	In this study, APE1 expression was down-regulated as a consequence phosphatidylinositol-3 kinase (PI3K) suppression by the inhibitor LY294002, but not by the suppression of MEK activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	15-19
27604655-8	2016	MAPK pathway inhibitor, U0126 and PI3KCA inhibitor LY294002 also decreased levels of ets-1, phosphor-ERK and phosphor-AKT on Western blot assay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	ETS proto-oncogene 1, transcription factor	Homo sapiens	85-90
27392709-10	2016	Both PI3K inhibitor LY294002 and mTOR inhibitor rapamycin decreased the augmented caspase-3 expression and TC content induced by ox-LDL, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	caspase 3	Homo sapiens	82-91
27208795-5	2016	AgRP-stimulated ERK1/2 phosphorylation through MC3R was abolished by protein kinase A (PKA) inhibitor H-89 but not Rp-cAMPS, whereas AgRP-initiated ERK1/2 activation through MC4R was inhibited by phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	259-267	agouti related neuropeptide	Homo sapiens	0-4
27217295-9	2016	Transfection of the let-7 antimiR significantly reduced the infarct size of diabetic rats (p &lt; 0.0001), and such an antiinfarct effect was abolished completely by pretreatment of Akt inhibitor LY294002 or mTOR inhibitor rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	AKT serine/threonine kinase 1	Rattus norvegicus	182-185
27217295-9	2016	Transfection of the let-7 antimiR significantly reduced the infarct size of diabetic rats (p &lt; 0.0001), and such an antiinfarct effect was abolished completely by pretreatment of Akt inhibitor LY294002 or mTOR inhibitor rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	mechanistic target of rapamycin kinase	Rattus norvegicus	208-212
27208795-5	2016	AgRP-stimulated ERK1/2 phosphorylation through MC3R was abolished by protein kinase A (PKA) inhibitor H-89 but not Rp-cAMPS, whereas AgRP-initiated ERK1/2 activation through MC4R was inhibited by phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	259-267	mitogen-activated protein kinase 3	Homo sapiens	148-154
27430327-10	2016	The JNK agonist, anisomycin, and the Akt inhibitor, LY294002, both significantly blocked the effects of propofol on hippocampal neuronal cell viability and apoptosis in IBI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	37-40
27586425-9	2016	Furthermore, we confirmed that Sal B has a protective role in miR-30a-mediated autophagy through the PI3K/Akt signaling pathway, which was abrogated by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	microRNA 30a	Homo sapiens	62-69
25986942-13	2016	Akt pathway inhibition by LY294002 or Akt siRNA reduced SOX2 mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	0-3
25986942-13	2016	Akt pathway inhibition by LY294002 or Akt siRNA reduced SOX2 mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	SRY-box transcription factor 2	Homo sapiens	56-60
27373678-10	2016	Moreover, LY294002 or the dominant-negative phosphoinositide 3-kinase (PI3K) mutant (Deltap85) attenuated HG-decreased Suv39h1 and HG-induced fibronectin and p21(WAF1) protein expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	suppressor of variegation 3-9 1	Mus musculus	119-126
27373678-10	2016	Moreover, LY294002 or the dominant-negative phosphoinositide 3-kinase (PI3K) mutant (Deltap85) attenuated HG-decreased Suv39h1 and HG-induced fibronectin and p21(WAF1) protein expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	fibronectin 1	Mus musculus	142-153
27373678-10	2016	Moreover, LY294002 or the dominant-negative phosphoinositide 3-kinase (PI3K) mutant (Deltap85) attenuated HG-decreased Suv39h1 and HG-induced fibronectin and p21(WAF1) protein expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	158-161
27373678-10	2016	Moreover, LY294002 or the dominant-negative phosphoinositide 3-kinase (PI3K) mutant (Deltap85) attenuated HG-decreased Suv39h1 and HG-induced fibronectin and p21(WAF1) protein expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	162-166
26374551-5	2016	A PI3K inhibitor LY294002 significantly decreased the levels of phospho-Akt, phospho-mTOR, phospho-p70S6K, and AChE protein expression in HG-cultured HT-22 cells, and an mTOR inhibitor rapamycin markedly reduced the levels of phospho-mTOR, phospho-p70S6K, and AChE expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	thymoma viral proto-oncogene 1	Mus musculus	72-75
27195653-7	2016	CMX-2043 stimulation of Akt phosphorylation was abolished by the phosphatidylinositide 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	AKT serine/threonine kinase 1	Homo sapiens	24-27
26374551-5	2016	A PI3K inhibitor LY294002 significantly decreased the levels of phospho-Akt, phospho-mTOR, phospho-p70S6K, and AChE protein expression in HG-cultured HT-22 cells, and an mTOR inhibitor rapamycin markedly reduced the levels of phospho-mTOR, phospho-p70S6K, and AChE expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	mechanistic target of rapamycin kinase	Mus musculus	85-89
26374551-5	2016	A PI3K inhibitor LY294002 significantly decreased the levels of phospho-Akt, phospho-mTOR, phospho-p70S6K, and AChE protein expression in HG-cultured HT-22 cells, and an mTOR inhibitor rapamycin markedly reduced the levels of phospho-mTOR, phospho-p70S6K, and AChE expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	99-105
26374551-5	2016	A PI3K inhibitor LY294002 significantly decreased the levels of phospho-Akt, phospho-mTOR, phospho-p70S6K, and AChE protein expression in HG-cultured HT-22 cells, and an mTOR inhibitor rapamycin markedly reduced the levels of phospho-mTOR, phospho-p70S6K, and AChE expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	acetylcholinesterase	Mus musculus	111-115
26374551-5	2016	A PI3K inhibitor LY294002 significantly decreased the levels of phospho-Akt, phospho-mTOR, phospho-p70S6K, and AChE protein expression in HG-cultured HT-22 cells, and an mTOR inhibitor rapamycin markedly reduced the levels of phospho-mTOR, phospho-p70S6K, and AChE expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	mechanistic target of rapamycin kinase	Mus musculus	170-174
26374551-5	2016	A PI3K inhibitor LY294002 significantly decreased the levels of phospho-Akt, phospho-mTOR, phospho-p70S6K, and AChE protein expression in HG-cultured HT-22 cells, and an mTOR inhibitor rapamycin markedly reduced the levels of phospho-mTOR, phospho-p70S6K, and AChE expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	mechanistic target of rapamycin kinase	Mus musculus	170-174
26374551-5	2016	A PI3K inhibitor LY294002 significantly decreased the levels of phospho-Akt, phospho-mTOR, phospho-p70S6K, and AChE protein expression in HG-cultured HT-22 cells, and an mTOR inhibitor rapamycin markedly reduced the levels of phospho-mTOR, phospho-p70S6K, and AChE expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	248-254
26374551-5	2016	A PI3K inhibitor LY294002 significantly decreased the levels of phospho-Akt, phospho-mTOR, phospho-p70S6K, and AChE protein expression in HG-cultured HT-22 cells, and an mTOR inhibitor rapamycin markedly reduced the levels of phospho-mTOR, phospho-p70S6K, and AChE expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	acetylcholinesterase	Mus musculus	260-264
27485415-11	2016	Additionally, the present study demonstrated that the effect of NC on the proliferation and apoptosis of ovarian cancer cells was Akt-dependent by using the phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt signaling pathway inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	237-245	AKT serine/threonine kinase 1	Homo sapiens	130-133
27588140-6	2016	Furthermore, IL-8 could induce AKT phosphorylation, and the phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitor LY294002 could inhibit the EMT of RCC cells that was induced by IL-8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
27161366-5	2016	To further certain the effectiveness of Akt signaling to the final outcome of cerebral ischemia, the animals were treated with LY294002, an inhibitor of the Akt pathway, which aggravated the ischemic injury in db/+ mice but not in db/db mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	thymoma viral proto-oncogene 1	Mus musculus	40-43
27161366-5	2016	To further certain the effectiveness of Akt signaling to the final outcome of cerebral ischemia, the animals were treated with LY294002, an inhibitor of the Akt pathway, which aggravated the ischemic injury in db/+ mice but not in db/db mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	thymoma viral proto-oncogene 1	Mus musculus	157-160
27461417-9	2016	We found that the basal levels of STC-1 expression in TNBC cells were decreased by treatment with LY294002 or Bay11-7085, but not SB203580.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	stanniocalcin 1	Homo sapiens	34-39
27378570-10	2016	LY294002 totally abrogated the infarct-limiting effect of GYY4137 and inhibited Akt, eNOS and GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	80-83
27378570-10	2016	LY294002 totally abrogated the infarct-limiting effect of GYY4137 and inhibited Akt, eNOS and GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 3	Homo sapiens	85-89
27378570-10	2016	LY294002 totally abrogated the infarct-limiting effect of GYY4137 and inhibited Akt, eNOS and GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Homo sapiens	94-103
27306214-10	2016	The effect of CP in the combination was replicated by the prototype AKT inhibitor LY294002, further supporting the role of AKT inhibition in the synergism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	68-71
27240591-11	2016	Specific inhibitors, LY294002 and PD98059, suppressed activation of AKT and ERK, which attenuated DU-145 cell clone formation and invasion induced by S100A16 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	68-71
27240591-11	2016	Specific inhibitors, LY294002 and PD98059, suppressed activation of AKT and ERK, which attenuated DU-145 cell clone formation and invasion induced by S100A16 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	mitogen-activated protein kinase 1	Homo sapiens	76-79
27240591-11	2016	Specific inhibitors, LY294002 and PD98059, suppressed activation of AKT and ERK, which attenuated DU-145 cell clone formation and invasion induced by S100A16 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	S100 calcium binding protein A16	Homo sapiens	150-157
27101199-9	2016	Notably, both PI3K inhibitor (LY294002) and BMX inhibitor (LFM-A13) impaired the chemoresistance enhanced by EPHA3 deficiency in SCLC cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	EPH receptor A3	Homo sapiens	109-114
27323966-8	2016	Moreover, LY294002, a PI3K inhibitor, can reverse the protein expression change of E-cadherin and snail induced by siGKN2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	cadherin 1	Homo sapiens	83-93
27323966-8	2016	Moreover, LY294002, a PI3K inhibitor, can reverse the protein expression change of E-cadherin and snail induced by siGKN2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	snail family transcriptional repressor 1	Homo sapiens	98-103
27489353-4	2016	HPV16 E6-E7 induced PI3K/Akt signaling pathway activation and this affect could be effectively inhibited by LY294002, a specific PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Homo sapiens	25-28
27545131-12	2016	(6) The expression of AKT/p-AKT was significantly lower in GSNO group than in the blank control group (P&lt; 0.05), which could be significantly upregulated by pretreatment with high, medium and low concentration ICA in a concentration-dependent manner, above effects could be blocked by LY294002 (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	288-296	AKT serine/threonine kinase 1	Homo sapiens	22-25
27545131-12	2016	(6) The expression of AKT/p-AKT was significantly lower in GSNO group than in the blank control group (P&lt; 0.05), which could be significantly upregulated by pretreatment with high, medium and low concentration ICA in a concentration-dependent manner, above effects could be blocked by LY294002 (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	288-296	AKT serine/threonine kinase 1	Homo sapiens	28-31
27545131-13	2016	(7) The expression of P53 was significantly higher in GSNO group than in the blank control group (P&lt; 0.05), which could be significantly down regulated by pretreatment with high, medium and low concentration ICA in a concentration-dependent manner, above effects could be blocked by LY294002(all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	286-294	tumor protein p53	Homo sapiens	22-25
27233800-7	2016	Pre-treatment with the PI3K inhibitor LY294002 inhibited Akt phosphorylation in sigmaA- and sigmaNS-expressing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	57-60
27512955-7	2016	Importantly, our results indicate, for the first time, that DR5 upregulation is mediated by autophagy, as blockade of CK-induced autophagy by 3-MA, LY294002 or Atg7 siRNAs substantially decreases DR5 upregulation and reduces the synergistic effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	TNF receptor superfamily member 10b	Homo sapiens	60-63
27147558-11	2016	Moreover, EGCG was similar to the phosphatidylinositol 3-kinase inhibitors wortmannin and LY-294002 to decrease protein kinase B (AKT) phosphorylation, cell number, and BrdU incorporation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-99	AKT serine/threonine kinase 1	Homo sapiens	130-133
27237619-15	2016	Decreased expression of BSEP and MRP2 caused by EE were also prevented by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	ATP binding cassette subfamily B member 11	Rattus norvegicus	24-28
27237619-15	2016	Decreased expression of BSEP and MRP2 caused by EE were also prevented by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	ATP binding cassette subfamily C member 2	Rattus norvegicus	33-37
27538808-7	2016	Not only Y27632 (1 uM), but also LY294002 (1 mM), inhibited KCl-induced Rock-II membrane translocation (p &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	72-79
27156691-9	2016	Moreover, blockade of PI3K/Akt activation by LY294002 significantly reduced inflammation response and NF-kappaB p65 nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	thymoma viral proto-oncogene 1	Mus musculus	27-30
27003241-10	2016	However, the synergistic effect was efficiently abolished by the phosphoinositide 3-kinase (PI3K)/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	thymoma viral proto-oncogene 1	Mus musculus	98-101
26346882-9	2016	The PI3/Akt inhibitor, LY294002, impeded the changes induced by agmatine, while ERK inhibitor (PD98059) did not disturb the effects of agmatine, and by itself, it preserved the cells against 6-OHDA toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	peptidase inhibitor 3	Homo sapiens	4-7
26346882-9	2016	The PI3/Akt inhibitor, LY294002, impeded the changes induced by agmatine, while ERK inhibitor (PD98059) did not disturb the effects of agmatine, and by itself, it preserved the cells against 6-OHDA toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	8-11
26440805-8	2016	Additionally, after treating with LY294002 or wortmannin [the selective inhibitors of phosphatidylinositol 3 kinase (PI3K)], HupA dramatically prevented the down-regulations of p-Akt, p-mTOR, and p-p70s6 kinase in HT22 cells under oxidative toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	86-115
26440805-8	2016	Additionally, after treating with LY294002 or wortmannin [the selective inhibitors of phosphatidylinositol 3 kinase (PI3K)], HupA dramatically prevented the down-regulations of p-Akt, p-mTOR, and p-p70s6 kinase in HT22 cells under oxidative toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	thymoma viral proto-oncogene 1	Mus musculus	179-182
26440805-8	2016	Additionally, after treating with LY294002 or wortmannin [the selective inhibitors of phosphatidylinositol 3 kinase (PI3K)], HupA dramatically prevented the down-regulations of p-Akt, p-mTOR, and p-p70s6 kinase in HT22 cells under oxidative toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	mechanistic target of rapamycin kinase	Mus musculus	186-190
27156691-9	2016	Moreover, blockade of PI3K/Akt activation by LY294002 significantly reduced inflammation response and NF-kappaB p65 nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-111
27156691-9	2016	Moreover, blockade of PI3K/Akt activation by LY294002 significantly reduced inflammation response and NF-kappaB p65 nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	112-115
27354148-13	2016	In addition, the specific PI3K-inhibitor LY294002 decreased IL-6 secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	interleukin 6	Homo sapiens	60-64
27446335-8	2016	Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway by pretreatment with the PI3K specific inhibitors wortmannin and LY294002 also eliminated the cardioprotective effects of tanshinone IIA against H2O2-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	AKT serine/threonine kinase 1	Rattus norvegicus	55-58
27055862-11	2016	The Nrf2-related cytoprotective effects of PUN were via the PI3K/Akt signalling pathway, as LY294002, a specific PI3K/Akt inhibitor, suppressed the PUN-induced nuclear translocation of Nrf2, the HO-1 up-regulation and the protective effect of PUN against oxidative stress.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	NFE2 like bZIP transcription factor 2	Rattus norvegicus	4-8
27055862-11	2016	The Nrf2-related cytoprotective effects of PUN were via the PI3K/Akt signalling pathway, as LY294002, a specific PI3K/Akt inhibitor, suppressed the PUN-induced nuclear translocation of Nrf2, the HO-1 up-regulation and the protective effect of PUN against oxidative stress.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
27055862-11	2016	The Nrf2-related cytoprotective effects of PUN were via the PI3K/Akt signalling pathway, as LY294002, a specific PI3K/Akt inhibitor, suppressed the PUN-induced nuclear translocation of Nrf2, the HO-1 up-regulation and the protective effect of PUN against oxidative stress.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
27055862-11	2016	The Nrf2-related cytoprotective effects of PUN were via the PI3K/Akt signalling pathway, as LY294002, a specific PI3K/Akt inhibitor, suppressed the PUN-induced nuclear translocation of Nrf2, the HO-1 up-regulation and the protective effect of PUN against oxidative stress.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	NFE2 like bZIP transcription factor 2	Rattus norvegicus	185-189
27055862-11	2016	The Nrf2-related cytoprotective effects of PUN were via the PI3K/Akt signalling pathway, as LY294002, a specific PI3K/Akt inhibitor, suppressed the PUN-induced nuclear translocation of Nrf2, the HO-1 up-regulation and the protective effect of PUN against oxidative stress.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	heme oxygenase 1	Rattus norvegicus	195-199
27242267-5	2016	Further mechanistic studies revealed that beta-LAP activated AMPK and Akt, and pretreatment of cells with an AMPK inhibitor (compound C) or PI3K/Akt inhibitor (LY294002) suppressed beta-LAP-induced antioxidant enzyme expression by inhibiting Nrf2/antioxidant response element (ARE) signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	AKT serine/threonine kinase 1	Rattus norvegicus	70-73
27242267-5	2016	Further mechanistic studies revealed that beta-LAP activated AMPK and Akt, and pretreatment of cells with an AMPK inhibitor (compound C) or PI3K/Akt inhibitor (LY294002) suppressed beta-LAP-induced antioxidant enzyme expression by inhibiting Nrf2/antioxidant response element (ARE) signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
27242267-5	2016	Further mechanistic studies revealed that beta-LAP activated AMPK and Akt, and pretreatment of cells with an AMPK inhibitor (compound C) or PI3K/Akt inhibitor (LY294002) suppressed beta-LAP-induced antioxidant enzyme expression by inhibiting Nrf2/antioxidant response element (ARE) signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	NFE2 like bZIP transcription factor 2	Rattus norvegicus	242-246
27363707-5	2016	We evaluated the levels of IkappaBalpha, a component of the classical activation pathway of the transcription factor NF-kappaB, and we observed IkappaBalpha reduction after stimulation with FFAR1/GPR40 agonists, an effect that was inhibited by GW1100 or the inhibitors UO126, SB203580 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	288-296	NFKB inhibitor alpha	Bos taurus	27-39
27363707-5	2016	We evaluated the levels of IkappaBalpha, a component of the classical activation pathway of the transcription factor NF-kappaB, and we observed IkappaBalpha reduction after stimulation with FFAR1/GPR40 agonists, an effect that was inhibited by GW1100 or the inhibitors UO126, SB203580 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	288-296	NFKB inhibitor alpha	Bos taurus	144-156
27363707-5	2016	We evaluated the levels of IkappaBalpha, a component of the classical activation pathway of the transcription factor NF-kappaB, and we observed IkappaBalpha reduction after stimulation with FFAR1/GPR40 agonists, an effect that was inhibited by GW1100 or the inhibitors UO126, SB203580 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	288-296	free fatty acid receptor 1	Bos taurus	190-195
27465322-12	2016	Silencing Mcl-1 by RNAi or LY294002 downregulated Mcl-1 expression and led to decreased cell viability and increased apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	50-55
26160762-9	2016	Furthermore, we found that the neuroprotective effect of B3C against Abeta-oligomer-induced impairments of synaptic formation and plasticity could be partially blocked by a specific phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 (50 muM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	230-238	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	182-211
26143260-5	2016	Inhibition of PI3K/Akt with LY294002 reduced proliferation and inhibited dopaminergic neuronal differentiation of these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	19-22
27357907-8	2016	Phosphoinositide-3-kinase (PI3K) inhibitor, LY294002 suppressed p-AKT and p-mTOR, indicating PI3K is a common upstream mediator.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-25
27357907-8	2016	Phosphoinositide-3-kinase (PI3K) inhibitor, LY294002 suppressed p-AKT and p-mTOR, indicating PI3K is a common upstream mediator.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	66-69
27357907-8	2016	Phosphoinositide-3-kinase (PI3K) inhibitor, LY294002 suppressed p-AKT and p-mTOR, indicating PI3K is a common upstream mediator.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	mechanistic target of rapamycin kinase	Homo sapiens	76-80
26932180-7	2016	LY294002, an inhibitor of PI3K, abrogated the effect of baicalin against ketamine-induced caspase-3 activity and caspase-3 mRNA expression increase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Rattus norvegicus	90-99
27016017-8	2016	A PI3K inhibitor LY294002 (but not the negative control LY303511) ablated the inhibitory effects of IL-10 on mIPSC area and Itonic, but not on mIPSC frequency, indicating the involvement of PI3K in postsynaptic effects of IL-10 on GABAergic transmission.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	interleukin 10	Rattus norvegicus	100-105
27016017-8	2016	A PI3K inhibitor LY294002 (but not the negative control LY303511) ablated the inhibitory effects of IL-10 on mIPSC area and Itonic, but not on mIPSC frequency, indicating the involvement of PI3K in postsynaptic effects of IL-10 on GABAergic transmission.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	interleukin 10	Rattus norvegicus	222-227
26932180-7	2016	LY294002, an inhibitor of PI3K, abrogated the effect of baicalin against ketamine-induced caspase-3 activity and caspase-3 mRNA expression increase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Rattus norvegicus	113-122
27446405-10	2016	Furthermore, inhibition of PI3K/Akt with LY294002 augmented CD147-mediated function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	32-35
27446405-10	2016	Furthermore, inhibition of PI3K/Akt with LY294002 augmented CD147-mediated function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	basigin (Ok blood group)	Homo sapiens	60-65
26886287-1	2016	This work aims to evaluate the impact of 2-morpholino-8-phenyl-4H-chromen-4-one (LY294002) combined 5-fluorouracil (5-FU) for the activity of CD90+ liver cancer cells derived from the human liver cancer cell line MHCC97H.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-79	Thy-1 cell surface antigen	Homo sapiens	142-146
26886287-6	2016	LY294002 reduced the expression of CD90, Nanog, SALL4, and SHP2 in a concentration-dependent manner in CD90+ LCCs and MSFCs, but not in parental cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Thy-1 cell surface antigen	Homo sapiens	35-39
26886287-1	2016	This work aims to evaluate the impact of 2-morpholino-8-phenyl-4H-chromen-4-one (LY294002) combined 5-fluorouracil (5-FU) for the activity of CD90+ liver cancer cells derived from the human liver cancer cell line MHCC97H.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	Thy-1 cell surface antigen	Homo sapiens	142-146
26886287-6	2016	LY294002 reduced the expression of CD90, Nanog, SALL4, and SHP2 in a concentration-dependent manner in CD90+ LCCs and MSFCs, but not in parental cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Nanog homeobox	Homo sapiens	41-46
26960693-9	2016	After administration with Nar, we found that phosphorylation of AKT was inhibited, and this inhibitory action could be mildly enhanced by the combination treatment of Nar and AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	AKT serine/threonine kinase 1	Homo sapiens	64-67
27126362-4	2016	Inhibition of AKT by wortmannin/LY294002 or overexpression of DAPK3 reverts the proliferative function of AKT in CaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	14-17
26960693-9	2016	After administration with Nar, we found that phosphorylation of AKT was inhibited, and this inhibitory action could be mildly enhanced by the combination treatment of Nar and AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	AKT serine/threonine kinase 1	Homo sapiens	175-178
26886287-6	2016	LY294002 reduced the expression of CD90, Nanog, SALL4, and SHP2 in a concentration-dependent manner in CD90+ LCCs and MSFCs, but not in parental cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	spalt like transcription factor 4	Homo sapiens	48-53
26886287-6	2016	LY294002 reduced the expression of CD90, Nanog, SALL4, and SHP2 in a concentration-dependent manner in CD90+ LCCs and MSFCs, but not in parental cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	59-63
26886287-6	2016	LY294002 reduced the expression of CD90, Nanog, SALL4, and SHP2 in a concentration-dependent manner in CD90+ LCCs and MSFCs, but not in parental cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Thy-1 cell surface antigen	Homo sapiens	103-107
26886287-6	2016	LY294002 reduced the expression of CD90, Nanog, SALL4, and SHP2 in a concentration-dependent manner in CD90+ LCCs and MSFCs, but not in parental cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GLE1 RNA export mediator	Homo sapiens	109-113
26886287-7	2016	LY294002 blocked AKT phosphorylation via the PI3K/AKT signaling pathway and inhibited CD90+ LCCs proliferation and tumorigenicity in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Thy-1 cell surface antigen	Homo sapiens	86-90
26886287-7	2016	LY294002 blocked AKT phosphorylation via the PI3K/AKT signaling pathway and inhibited CD90+ LCCs proliferation and tumorigenicity in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GLE1 RNA export mediator	Homo sapiens	92-96
26886287-9	2016	LY294002 inhibits the proliferation and invasion of MHCC97H-derived CD90+ LCCs and sensitized CD90+ LCCs-derived tumors to 5-FU in the current study which may provide insight into the association between the LY294002 combined 5-FU and liver cancer stem cell (LCSCs).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Thy-1 cell surface antigen	Homo sapiens	68-72
26886287-9	2016	LY294002 inhibits the proliferation and invasion of MHCC97H-derived CD90+ LCCs and sensitized CD90+ LCCs-derived tumors to 5-FU in the current study which may provide insight into the association between the LY294002 combined 5-FU and liver cancer stem cell (LCSCs).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GLE1 RNA export mediator	Homo sapiens	74-78
26886287-9	2016	LY294002 inhibits the proliferation and invasion of MHCC97H-derived CD90+ LCCs and sensitized CD90+ LCCs-derived tumors to 5-FU in the current study which may provide insight into the association between the LY294002 combined 5-FU and liver cancer stem cell (LCSCs).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Thy-1 cell surface antigen	Homo sapiens	94-98
26886287-9	2016	LY294002 inhibits the proliferation and invasion of MHCC97H-derived CD90+ LCCs and sensitized CD90+ LCCs-derived tumors to 5-FU in the current study which may provide insight into the association between the LY294002 combined 5-FU and liver cancer stem cell (LCSCs).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GLE1 RNA export mediator	Homo sapiens	100-104
27323812-8	2016	The proliferation, cellular growth and glucose consumption of ARID1A-deficient GC cells were efficiently prohibited by allosteric inhibitors mk2206 and LY294002, which targeting AKT and PI3K, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	thymoma viral proto-oncogene 1	Mus musculus	178-181
27463705-8	2016	BA-induced eNOS phosphorylation and NO production was completely blocked by pretreatment with ICI 182,780, and was attenuated by pretreatment with the PI3K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	nitric oxide synthase 3	Homo sapiens	11-15
32263421-8	2016	Activation of Akt signaling pathways was observed in MSCs cultured with SiO2@Ru and these enhancement effects could be blocked by the Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Homo sapiens	14-17
27216460-7	2016	We also found that the inhibition of PI3K/Akt activation by LY294002, a PI3K inhibitor, reduced cell proliferation and protein level of GATA4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	42-45
27216460-7	2016	We also found that the inhibition of PI3K/Akt activation by LY294002, a PI3K inhibitor, reduced cell proliferation and protein level of GATA4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	GATA binding protein 4	Homo sapiens	136-141
27323812-11	2016	The administration of LY294002 alone inhibited the in vivo growth of ARID1A- deficient GC cells in mouse xenograft model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AT rich interactive domain 1A (SWI-like)	Mus musculus	69-75
27323826-9	2016	PI3K/Akt inhibitor (LY294002) and ERK inhibitor (PD98059) suppressed simvastatin-induced Nrf2 and HO-1 expression in both HT-29 and HCT 116 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	5-8
27323826-9	2016	PI3K/Akt inhibitor (LY294002) and ERK inhibitor (PD98059) suppressed simvastatin-induced Nrf2 and HO-1 expression in both HT-29 and HCT 116 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	NFE2 like bZIP transcription factor 2	Homo sapiens	89-93
27323826-9	2016	PI3K/Akt inhibitor (LY294002) and ERK inhibitor (PD98059) suppressed simvastatin-induced Nrf2 and HO-1 expression in both HT-29 and HCT 116 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	heme oxygenase 1	Homo sapiens	98-102
27207584-8	2016	Furthermore, inhibition of miR-138-5p downregulated PTEN protein expression and promoted activation of PI3K/AKT, and knockdown of either SIRT1 or the PI3K/Akt inhibitor (LY294002) abolished the effect of miR-138-5p on NP cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Homo sapiens	155-158
27130665-9	2016	Inhibition of the PI3K/AKT pathway by LY294002 significantly attenuated MMP1-mediated cell proliferation and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	23-26
27130665-9	2016	Inhibition of the PI3K/AKT pathway by LY294002 significantly attenuated MMP1-mediated cell proliferation and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	matrix metallopeptidase 1	Homo sapiens	72-76
27129295-5	2016	Human conditional immortalized podocytes exposed to mechanical stress were treated with spironolactone, LY294002 or rapamycin for 48 h. The accumulation of LC3 puncta was detected by immunofluorescence staining.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	156-159
32263421-8	2016	Activation of Akt signaling pathways was observed in MSCs cultured with SiO2@Ru and these enhancement effects could be blocked by the Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Homo sapiens	134-137
27196724-6	2016	LY294002, the specific inhibitor of phosphoinositide 3-kinase, significantly abrogated the upregulated phosphorylated AKT and phosphorylated GSK3beta offered by Soya-I, suggesting that the neuroprotection of Soya-I was mainly dependent on the activation of the phosphoinositide 3-kinase/AKT/GSK3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	118-121
27065095-9	2016	Inhibition of phosphoinositide-3-kinase (PI3K)/Akt pathway through LY294002 attenuated cerebral protection conferred by argon-hypothermia treatment (n = 8).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Rattus norvegicus	47-50
27196724-6	2016	LY294002, the specific inhibitor of phosphoinositide 3-kinase, significantly abrogated the upregulated phosphorylated AKT and phosphorylated GSK3beta offered by Soya-I, suggesting that the neuroprotection of Soya-I was mainly dependent on the activation of the phosphoinositide 3-kinase/AKT/GSK3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 alpha	Homo sapiens	141-149
27196724-6	2016	LY294002, the specific inhibitor of phosphoinositide 3-kinase, significantly abrogated the upregulated phosphorylated AKT and phosphorylated GSK3beta offered by Soya-I, suggesting that the neuroprotection of Soya-I was mainly dependent on the activation of the phosphoinositide 3-kinase/AKT/GSK3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	287-290
27196724-6	2016	LY294002, the specific inhibitor of phosphoinositide 3-kinase, significantly abrogated the upregulated phosphorylated AKT and phosphorylated GSK3beta offered by Soya-I, suggesting that the neuroprotection of Soya-I was mainly dependent on the activation of the phosphoinositide 3-kinase/AKT/GSK3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 alpha	Homo sapiens	291-299
27399653-8	2016	Significantly, an Akt inhibitor (LY294002) or HO-1 inhibitor (ZnPP) not only inhibited myricitrin-induced HO-1/NQO-1 upregulation but also alleviated its anti-apoptotic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
27399653-8	2016	Significantly, an Akt inhibitor (LY294002) or HO-1 inhibitor (ZnPP) not only inhibited myricitrin-induced HO-1/NQO-1 upregulation but also alleviated its anti-apoptotic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	heme oxygenase 1	Rattus norvegicus	106-110
27399653-8	2016	Significantly, an Akt inhibitor (LY294002) or HO-1 inhibitor (ZnPP) not only inhibited myricitrin-induced HO-1/NQO-1 upregulation but also alleviated its anti-apoptotic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	111-116
27104982-7	2016	Furthermore, we found the effect of TDRG1 knockdown or TDRG1 overexpression could be reversed by IGF-1, a PI3K signaling activator, or LY294002, a inhibitor of this pathway, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	testis development related 1	Homo sapiens	36-41
27104982-7	2016	Furthermore, we found the effect of TDRG1 knockdown or TDRG1 overexpression could be reversed by IGF-1, a PI3K signaling activator, or LY294002, a inhibitor of this pathway, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	testis development related 1	Homo sapiens	55-60
26154142-6	2016	Furthermore, PI3K/AKT inhibition (by LY294002) completely blocked CCL20-induced Snail and NF-kB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	18-21
27170343-10	2016	Additionally, either LY294002 or U0126 treatment could inhibit STAT3 phosphorylation, whereas AG490 administration also reduced both Akt and ERK1/2 phosphorylation, indicating an interplay exists between RISK and SAFE pathways in melatonin"s cardioprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	signal transducer and activator of transcription 3	Rattus norvegicus	63-68
25956684-6	2016	Phosphatidylinositol-3-kinase (PI3K)-specific signaling was checked by using the PI3K-inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-29
27176045-10	2016	The PI3K/Akt signaling pathway is of importance in regulating MMP2 expression in Sk-hep-1 cells, since Robo1 overexpression stimulated phosphorylation of Akt while the PI3K inhibitor LY294002, significantly inhibited the upregulation of MMP2 and also the enhanced cell invasion induced by Robo1 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	AKT serine/threonine kinase 1	Homo sapiens	9-12
27176045-10	2016	The PI3K/Akt signaling pathway is of importance in regulating MMP2 expression in Sk-hep-1 cells, since Robo1 overexpression stimulated phosphorylation of Akt while the PI3K inhibitor LY294002, significantly inhibited the upregulation of MMP2 and also the enhanced cell invasion induced by Robo1 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	matrix metallopeptidase 2	Homo sapiens	62-66
27176505-11	2016	Of note, the PI3K pathway inhibitor LY-294002 significantly enhanced the apoptotic potential of TRAIL and PBOX-15 validating the importance of Akt downregulation in the TRAIL/PBOX-15 synergistic combination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-45	TNF superfamily member 10	Homo sapiens	96-101
27085942-11	2016	The potential inhibitory effects downstream of the Akt and ERK signaling pathways were examined by administration of specific inhibitors LY294002 and PD98059 in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	AKT serine/threonine kinase 1	Rattus norvegicus	51-54
27085942-16	2016	The administration of PI3K/Akt and MAPK/ERK signaling pathway specific inhibitors, LY294002 and PD98059, suppressed expression of both p-Akt and p-ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	AKT serine/threonine kinase 1	Rattus norvegicus	27-30
27085942-16	2016	The administration of PI3K/Akt and MAPK/ERK signaling pathway specific inhibitors, LY294002 and PD98059, suppressed expression of both p-Akt and p-ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	AKT serine/threonine kinase 1	Rattus norvegicus	137-140
27176505-11	2016	Of note, the PI3K pathway inhibitor LY-294002 significantly enhanced the apoptotic potential of TRAIL and PBOX-15 validating the importance of Akt downregulation in the TRAIL/PBOX-15 synergistic combination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-45	AKT serine/threonine kinase 1	Homo sapiens	143-146
27176505-11	2016	Of note, the PI3K pathway inhibitor LY-294002 significantly enhanced the apoptotic potential of TRAIL and PBOX-15 validating the importance of Akt downregulation in the TRAIL/PBOX-15 synergistic combination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-45	TNF superfamily member 10	Homo sapiens	169-174
27176815-9	2016	Furthermore, the Akt inhibitor, LY294002, partially hampered the expression of Nrf2 and HO-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	17-20
27176815-9	2016	Furthermore, the Akt inhibitor, LY294002, partially hampered the expression of Nrf2 and HO-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	79-83
27176815-9	2016	Furthermore, the Akt inhibitor, LY294002, partially hampered the expression of Nrf2 and HO-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	heme oxygenase 1	Rattus norvegicus	88-92
26154142-6	2016	Furthermore, PI3K/AKT inhibition (by LY294002) completely blocked CCL20-induced Snail and NF-kB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	C-C motif chemokine ligand 20	Homo sapiens	66-71
26154142-6	2016	Furthermore, PI3K/AKT inhibition (by LY294002) completely blocked CCL20-induced Snail and NF-kB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	snail family transcriptional repressor 1	Homo sapiens	80-85
27177125-5	2016	The cells in the Akt pathway blockage group were treated with 25 microM LY294002 for 1 h, followed by ginsenoside Rg1 + H2O2 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	thymoma viral proto-oncogene 1	Mus musculus	17-20
26994872-6	2016	LY294002, the specific inhibitor of PI3-K, significantly abrogated the up-regulated phosphorylated Akt and phosphorylated GSK3beta offered by TA, suggesting that the neuroprotection of TA was mainly dependent on the activation of PI3-K/Akt/GSK3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	99-102
26994872-6	2016	LY294002, the specific inhibitor of PI3-K, significantly abrogated the up-regulated phosphorylated Akt and phosphorylated GSK3beta offered by TA, suggesting that the neuroprotection of TA was mainly dependent on the activation of PI3-K/Akt/GSK3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Homo sapiens	122-130
27038931-4	2016	As to Nav1.9, changes in current density and kinetic properties of Nav1.9 current evoked by SDF-1(50 ng/ml) was eliminated by CXCR4 antagonist AMD3100 and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	C-X-C motif chemokine ligand 12	Rattus norvegicus	92-97
27038931-4	2016	As to Nav1.9, changes in current density and kinetic properties of Nav1.9 current evoked by SDF-1(50 ng/ml) was eliminated by CXCR4 antagonist AMD3100 and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	C-X-C motif chemokine receptor 4	Rattus norvegicus	126-131
26961889-11	2016	Furthermore, apelin-13-mediated anti-viability loss, antiapoptosis and caspase-3 suppression activities were blocked by specific inhibitors of phosphatidylinositol 3-kinase (PI3K) (LY294002) and ERKs (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	apelin	Rattus norvegicus	13-19
26994872-6	2016	LY294002, the specific inhibitor of PI3-K, significantly abrogated the up-regulated phosphorylated Akt and phosphorylated GSK3beta offered by TA, suggesting that the neuroprotection of TA was mainly dependent on the activation of PI3-K/Akt/GSK3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	236-239
26994872-6	2016	LY294002, the specific inhibitor of PI3-K, significantly abrogated the up-regulated phosphorylated Akt and phosphorylated GSK3beta offered by TA, suggesting that the neuroprotection of TA was mainly dependent on the activation of PI3-K/Akt/GSK3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Homo sapiens	240-248
27347100-9	2016	LY294002 blocked the PI3K/AKT/mTOR pathway and induced autophagy and apoptosis of A549 cells, however, no synergistic effect was observed following combined treatment with gefitinib and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	26-29
27221674-6	2016	Knockdown of HIF-1alpha by shRNA and LY294002 was used to inhibit the activity of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
27221674-6	2016	Knockdown of HIF-1alpha by shRNA and LY294002 was used to inhibit the activity of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	87-90
27347100-9	2016	LY294002 blocked the PI3K/AKT/mTOR pathway and induced autophagy and apoptosis of A549 cells, however, no synergistic effect was observed following combined treatment with gefitinib and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	30-34
30634213-20	2016	p-Akt protein expression in HUVECs was inhibited after adding specific P13K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	AKT serine/threonine kinase 1	Homo sapiens	2-5
26787540-4	2016	The effects of B7-H3 on activation of the PI3K/Akt pathway and elevation of TS expression could be blocked by LY294002, a specific inhibitor of the PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	CD276 antigen	Mus musculus	15-20
26787540-4	2016	The effects of B7-H3 on activation of the PI3K/Akt pathway and elevation of TS expression could be blocked by LY294002, a specific inhibitor of the PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	thymoma viral proto-oncogene 1	Mus musculus	47-50
26787540-4	2016	The effects of B7-H3 on activation of the PI3K/Akt pathway and elevation of TS expression could be blocked by LY294002, a specific inhibitor of the PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	thymidylate synthase	Mus musculus	76-78
26568302-10	2016	The specific inhibitor (Ly294002) of PI3K/AKT pathway significantly decreased expression of miR-21 and CSC markers and upregulated the expression of PTEN, which indicates that miR-21 and PTEN are the downstream effectors of PI3K/AKT and that expression of these two effectors are related to the development of NPC CSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	42-45
26568302-10	2016	The specific inhibitor (Ly294002) of PI3K/AKT pathway significantly decreased expression of miR-21 and CSC markers and upregulated the expression of PTEN, which indicates that miR-21 and PTEN are the downstream effectors of PI3K/AKT and that expression of these two effectors are related to the development of NPC CSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	microRNA 21	Homo sapiens	92-98
26568302-10	2016	The specific inhibitor (Ly294002) of PI3K/AKT pathway significantly decreased expression of miR-21 and CSC markers and upregulated the expression of PTEN, which indicates that miR-21 and PTEN are the downstream effectors of PI3K/AKT and that expression of these two effectors are related to the development of NPC CSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	phosphatase and tensin homolog	Homo sapiens	149-153
26568302-10	2016	The specific inhibitor (Ly294002) of PI3K/AKT pathway significantly decreased expression of miR-21 and CSC markers and upregulated the expression of PTEN, which indicates that miR-21 and PTEN are the downstream effectors of PI3K/AKT and that expression of these two effectors are related to the development of NPC CSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	microRNA 21	Homo sapiens	176-182
26568302-10	2016	The specific inhibitor (Ly294002) of PI3K/AKT pathway significantly decreased expression of miR-21 and CSC markers and upregulated the expression of PTEN, which indicates that miR-21 and PTEN are the downstream effectors of PI3K/AKT and that expression of these two effectors are related to the development of NPC CSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	phosphatase and tensin homolog	Homo sapiens	187-191
26568302-10	2016	The specific inhibitor (Ly294002) of PI3K/AKT pathway significantly decreased expression of miR-21 and CSC markers and upregulated the expression of PTEN, which indicates that miR-21 and PTEN are the downstream effectors of PI3K/AKT and that expression of these two effectors are related to the development of NPC CSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	229-232
27206970-9	2016	Treatment of VSMCs with PI3K inhibitor LY294002 abrogated the downregulating effect of testosterone on MMP-2 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	matrix metallopeptidase 2	Homo sapiens	103-108
26994515-8	2016	However, the phosphorylation of AKT, P70S6K, P90RSK and S6K was reduced in naringenin-induced pTr cells pre-treated with a PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Homo sapiens	32-35
26994515-8	2016	However, the phosphorylation of AKT, P70S6K, P90RSK and S6K was reduced in naringenin-induced pTr cells pre-treated with a PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	ribosomal protein S6 kinase B1	Homo sapiens	37-43
26994515-8	2016	However, the phosphorylation of AKT, P70S6K, P90RSK and S6K was reduced in naringenin-induced pTr cells pre-treated with a PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	ribosomal protein S6 kinase A1	Homo sapiens	45-51
26994515-8	2016	However, the phosphorylation of AKT, P70S6K, P90RSK and S6K was reduced in naringenin-induced pTr cells pre-treated with a PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	ribosomal protein S6 kinase B1	Homo sapiens	40-43
28881576-5	2017	LY294002, a PI3K inhibitor, defined the contribution of the PI3K/Akt/mTOR signaling pathway in CCSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	65-68
28881576-5	2017	LY294002, a PI3K inhibitor, defined the contribution of the PI3K/Akt/mTOR signaling pathway in CCSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	69-73
28881576-6	2017	LY294002-treated CCSCs showed decreases in proliferation, sphere formation and self-renewal, in phosphorylation-dependent activation of Akt, and in expression of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	136-139
28881576-6	2017	LY294002-treated CCSCs showed decreases in proliferation, sphere formation and self-renewal, in phosphorylation-dependent activation of Akt, and in expression of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin D1	Homo sapiens	162-171
27326255-12	2016	Furthermore, high expression levels of PI3K and EphA2 phosphorylation at Ser897 significantly correlated with the presence of vasculogenic mimicry and in vitro inhibition of PI3K by LY294002 disrupted vasculogenic mimicry, potentially through a reduction of EphA2 phosphorylation at Ser897.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	EPH receptor A2	Homo sapiens	48-53
27326255-12	2016	Furthermore, high expression levels of PI3K and EphA2 phosphorylation at Ser897 significantly correlated with the presence of vasculogenic mimicry and in vitro inhibition of PI3K by LY294002 disrupted vasculogenic mimicry, potentially through a reduction of EphA2 phosphorylation at Ser897.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	EPH receptor A2	Homo sapiens	258-263
27288247-12	2016	The protective effects of ghrelin mentioned above were abolished by LY294002 (LY), a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	ghrelin	Mus musculus	26-33
26979714-5	2016	BBR attenuated reactive oxygen species production, antioxidant defense (GSH and SOD) and oxidant-sensitive proteins (Nrf2 and HO-1), which also were blocked by LY294002 (an inhibitor of PI3K) in HG-treated NRK-52E and HK-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	NFE2 like bZIP transcription factor 2	Rattus norvegicus	117-121
27288247-12	2016	The protective effects of ghrelin mentioned above were abolished by LY294002 (LY), a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-70	ghrelin	Mus musculus	26-33
27082119-8	2016	First, c-Met (a receptor of HGF) tyrosine kinase inhibitor PHA-665752, and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 both suppress IDO expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	indoleamine 2,3-dioxygenase 1	Homo sapiens	145-148
27035160-8	2016	Inhibition of PI3-kinase, ERK-1/2, and p38 kinase with LY294002, PD98059, and SB203580, respectively, in the presence of SAL suppressed the metastatic capacity by reducing MMP-2 expression, as determined by gelatin zymography.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	mitogen-activated protein kinase 3	Homo sapiens	26-33
27081862-8	2016	Furthermore, pre-treatment with LY294002, a selective inhibitor of PI3K/Akt, reversed the protective effect of H2S against DOX-induced injury of cardiomyocytes, as demonstrated by an increased number of apoptotic cells, a decrease in cell viability and the reduced phosphorylation of Akt and FoxO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
27081862-8	2016	Furthermore, pre-treatment with LY294002, a selective inhibitor of PI3K/Akt, reversed the protective effect of H2S against DOX-induced injury of cardiomyocytes, as demonstrated by an increased number of apoptotic cells, a decrease in cell viability and the reduced phosphorylation of Akt and FoxO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	284-287
27081862-8	2016	Furthermore, pre-treatment with LY294002, a selective inhibitor of PI3K/Akt, reversed the protective effect of H2S against DOX-induced injury of cardiomyocytes, as demonstrated by an increased number of apoptotic cells, a decrease in cell viability and the reduced phosphorylation of Akt and FoxO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	forkhead box O3	Rattus norvegicus	292-298
27125675-10	2016	Furthermore, JNK inhibitor SP600125 and Akt (Ser473) inhibitor LY294002 enhanced the inhibition of curcumol on NF-kappaB p65 nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	AKT serine/threonine kinase 1	Homo sapiens	40-43
27035160-8	2016	Inhibition of PI3-kinase, ERK-1/2, and p38 kinase with LY294002, PD98059, and SB203580, respectively, in the presence of SAL suppressed the metastatic capacity by reducing MMP-2 expression, as determined by gelatin zymography.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	mitogen-activated protein kinase 1	Homo sapiens	39-42
27035160-8	2016	Inhibition of PI3-kinase, ERK-1/2, and p38 kinase with LY294002, PD98059, and SB203580, respectively, in the presence of SAL suppressed the metastatic capacity by reducing MMP-2 expression, as determined by gelatin zymography.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	matrix metallopeptidase 2	Homo sapiens	172-177
27113449-11	2016	PI3K-inhibitor (LY294002) could rescue the promotion of degranulation caused by miR-221 in IgE-mediated activation of mast cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	microRNA 221	Rattus norvegicus	80-87
27125675-10	2016	Furthermore, JNK inhibitor SP600125 and Akt (Ser473) inhibitor LY294002 enhanced the inhibition of curcumol on NF-kappaB p65 nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	nuclear factor kappa B subunit 1	Homo sapiens	111-120
27125675-11	2016	Finally, supplementation with SP600125, LY294002, or NF-kappaB inhibitor Ammonium pyrrolidinedithiocarbamate (PDTC) significantly enhanced the inhibitory effect of curcumol on MMP-9 expression and cell migration, invasion, and adhesion in MDA-MB-231 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	matrix metallopeptidase 9	Homo sapiens	176-181
26733168-9	2016	Using the Akt inhibitor LY294002 or knocking down Snail expression via RNA interference (RNAi) reversed the effects of oxaliplatin on the EMT and metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	10-13
26769343-6	2016	Inhibition of the PI3K/Akt pathways by a specific inhibitor, LY294002, suppresses EGF-induced Rac1 activation as well as tight junction (TJ) and adherens junction (AJ) expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	Rac family small GTPase 1	Rattus norvegicus	94-98
27338800-6	2016	An AKT inhibitor LY294002 blocked VEGF-A expression and AKT phosphorylation in HepG2 cells and NLRC5-overexpressing HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	AKT serine/threonine kinase 1	Homo sapiens	3-6
27338800-6	2016	An AKT inhibitor LY294002 blocked VEGF-A expression and AKT phosphorylation in HepG2 cells and NLRC5-overexpressing HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	vascular endothelial growth factor A	Homo sapiens	34-40
27338800-6	2016	An AKT inhibitor LY294002 blocked VEGF-A expression and AKT phosphorylation in HepG2 cells and NLRC5-overexpressing HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	AKT serine/threonine kinase 1	Homo sapiens	56-59
26769343-6	2016	Inhibition of the PI3K/Akt pathways by a specific inhibitor, LY294002, suppresses EGF-induced Rac1 activation as well as tight junction (TJ) and adherens junction (AJ) expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
26769343-6	2016	Inhibition of the PI3K/Akt pathways by a specific inhibitor, LY294002, suppresses EGF-induced Rac1 activation as well as tight junction (TJ) and adherens junction (AJ) expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	epidermal growth factor like 1	Rattus norvegicus	82-85
26961886-4	2016	Blocking of Akt1 pathway activation with different inhibitor (MK-2206 or LY294002) significantly attenuated mechanical allodynia and thermal hyperalgesia induced by paclitaxel.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Rattus norvegicus	12-16
27058759-10	2016	While inhibitor of PI3K/Akt, LY294002, abolishes visfatin induced up regulation of Snail, Vimentin (Vim), beta-catenin, and phosphorylated GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	nicotinamide phosphoribosyltransferase	Homo sapiens	49-57
27058759-10	2016	While inhibitor of PI3K/Akt, LY294002, abolishes visfatin induced up regulation of Snail, Vimentin (Vim), beta-catenin, and phosphorylated GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	snail family transcriptional repressor 1	Homo sapiens	83-88
27058759-10	2016	While inhibitor of PI3K/Akt, LY294002, abolishes visfatin induced up regulation of Snail, Vimentin (Vim), beta-catenin, and phosphorylated GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	vimentin	Homo sapiens	90-98
27058759-10	2016	While inhibitor of PI3K/Akt, LY294002, abolishes visfatin induced up regulation of Snail, Vimentin (Vim), beta-catenin, and phosphorylated GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	vimentin	Homo sapiens	90-93
27058759-10	2016	While inhibitor of PI3K/Akt, LY294002, abolishes visfatin induced up regulation of Snail, Vimentin (Vim), beta-catenin, and phosphorylated GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	catenin beta 1	Homo sapiens	106-118
27058759-10	2016	While inhibitor of PI3K/Akt, LY294002, abolishes visfatin induced up regulation of Snail, Vimentin (Vim), beta-catenin, and phosphorylated GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	glycogen synthase kinase 3 beta	Homo sapiens	139-148
27144449-6	2016	The administration of both PI3K/Akt inhibitor LY294002 and mTOR inhibitor rapamycin demonstrated that Akt/mTOR-regulated autophagy was involved in the hypoxia/reperfusion-induced microglia apoptosis/death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	32-35
26949052-8	2016	Inhibition of PI3K/AKT with LY294002 and/or Rac1 with NSC23766 impaired Nectin-4-mediated GBC cell proliferation and motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	nectin cell adhesion molecule 4	Homo sapiens	72-80
27144449-6	2016	The administration of both PI3K/Akt inhibitor LY294002 and mTOR inhibitor rapamycin demonstrated that Akt/mTOR-regulated autophagy was involved in the hypoxia/reperfusion-induced microglia apoptosis/death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	102-105
27144449-6	2016	The administration of both PI3K/Akt inhibitor LY294002 and mTOR inhibitor rapamycin demonstrated that Akt/mTOR-regulated autophagy was involved in the hypoxia/reperfusion-induced microglia apoptosis/death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	mechanistic target of rapamycin kinase	Homo sapiens	106-110
26940012-8	2016	Moreover, the inhibitory effect of LY294002 (a specific PI3K inhibitor) on the activities of AKT and ERK1/2 was partially recovered by overexpression of MAT2B in porcine intramuscular adipocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	93-96
27194135-15	2016	Preincubation with beta2AR inhibitor (ICI118,551), Akt inhibitor (ly294002), or eNOS inhibitor (L-NAME) significantly attenuated the enhanced in vitro function and in vivo re-endothelialization capacity of EPCs induced by beta2AR overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	thymoma viral proto-oncogene 1	Mus musculus	51-54
27129169-11	2016	Importantly, the effects of betacellulin on E-cadherin, Slug and cell migration were attenuated by pre-treatment with either U0126 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	betacellulin	Homo sapiens	28-40
27129169-11	2016	Importantly, the effects of betacellulin on E-cadherin, Slug and cell migration were attenuated by pre-treatment with either U0126 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	cadherin 1	Homo sapiens	44-54
27129169-11	2016	Importantly, the effects of betacellulin on E-cadherin, Slug and cell migration were attenuated by pre-treatment with either U0126 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	snail family transcriptional repressor 2	Homo sapiens	56-60
26940012-8	2016	Moreover, the inhibitory effect of LY294002 (a specific PI3K inhibitor) on the activities of AKT and ERK1/2 was partially recovered by overexpression of MAT2B in porcine intramuscular adipocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	mitogen-activated protein kinase 3	Homo sapiens	101-107
26940012-8	2016	Moreover, the inhibitory effect of LY294002 (a specific PI3K inhibitor) on the activities of AKT and ERK1/2 was partially recovered by overexpression of MAT2B in porcine intramuscular adipocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	methionine adenosyltransferase 2B	Homo sapiens	153-158
27156963-6	2016	Treatment of PI3K inhibitor LY294002 markedly prevented phosphorylation of AKT and subsequently counteract aggressive phenotype mediated by siRNA of 14-3-3sigma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	75-78
26902516-8	2016	Then we used MTEP, mGluR5 knockdown, the ERK1/2 inhibitor U0126 and the AKT inhibitor LY294002 to pretreat the cells, and all of them clearly eliminated the influence of DHPG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
27059137-9	2016	Even more importantly, we discovered that Sam68 could enhance the phosphorylation of Akt while LY294002 (a PI3K inhibitor) obviously reversed Sam68-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	142-147
27119510-6	2016	Furthermore, miR-93 mimic significantly increased p-Akt levels under H/R, which was partially released by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	microRNA 9-3	Homo sapiens	13-19
27119510-6	2016	Furthermore, miR-93 mimic significantly increased p-Akt levels under H/R, which was partially released by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	AKT serine/threonine kinase 1	Homo sapiens	52-55
27156963-6	2016	Treatment of PI3K inhibitor LY294002 markedly prevented phosphorylation of AKT and subsequently counteract aggressive phenotype mediated by siRNA of 14-3-3sigma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	stratifin	Homo sapiens	149-160
26923440-5	2016	Using the inhibitors AH7614, K252c, U0126, wortmannin, and LY294002, we demonstrate that the effect of DHA is mediated through GPR120 to downstream PKC/MAPK and PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	free fatty acid receptor 4	Homo sapiens	127-133
30090420-9	2016	In T-HaCaT cells, blocking the activation of Akt by LY294002 inhibited the EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	45-48
30090420-10	2016	Moreover, the effects of an miR-21 mimic on the EMT and the neoplastic capacity, invasion, and metastasis of T-HaCaT cells were antagonized by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	microRNA 21	Homo sapiens	28-34
29771028-4	2016	PI3K-Akt pathway was inhibited by LY294002 in CNE 1 and CNE 1+ LMP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	5-8
27168723-5	2015	c-myc activation was inhibited upon treatment with ERK, PI3 kinase, and c-src pathway inhibitors, U0126, LY294002, and PP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
29771028-4	2016	PI3K-Akt pathway was inhibited by LY294002 in CNE 1 and CNE 1+ LMP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	PDZ and LIM domain 7	Homo sapiens	63-67
29771028-9	2016	With 1 mumol/ml LY294002 pretreatment for 8 hours, p-Akt expression was both downregulated in CNE 1 and CNE 1+ LMP1, but there was no significant difference between them(P &gt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	53-56
29771028-9	2016	With 1 mumol/ml LY294002 pretreatment for 8 hours, p-Akt expression was both downregulated in CNE 1 and CNE 1+ LMP1, but there was no significant difference between them(P &gt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	PDZ and LIM domain 7	Homo sapiens	111-115
27017522-6	2016	Inhibition of NF-kB (BAY 11-7085), JNK (SP600125) and PI3K (LY294002) signaling pathways decreased the expression of TREM-1 (p &lt; 0.01), MMP-1 (p &lt; 0.001) and MMP-9 (p &lt; 0.01) in TNF-alpha-treated VSMCs isolated from S carotid plaques compared to AS patients.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	triggering receptor expressed on myeloid cells 1	Homo sapiens	117-123
27146881-8	2016	The AKT inhibitor, LY294002, and the knockdown of AKT expression reversed the rIL-17B-induced upregulation of beta-catenin and some stemness markers.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	interleukin 17B	Rattus norvegicus	78-85
27146881-8	2016	The AKT inhibitor, LY294002, and the knockdown of AKT expression reversed the rIL-17B-induced upregulation of beta-catenin and some stemness markers.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	catenin beta 1	Homo sapiens	110-122
26919896-11	2016	Inhibition of the phosphatidylinositol 3-kinase/Akt pathway using LY294002 prevented cytomix-induced ERK activation and augmented cytomix-induced caspase-3 cleavage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	48-51
26919896-11	2016	Inhibition of the phosphatidylinositol 3-kinase/Akt pathway using LY294002 prevented cytomix-induced ERK activation and augmented cytomix-induced caspase-3 cleavage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	mitogen-activated protein kinase 1	Homo sapiens	101-104
26919896-11	2016	Inhibition of the phosphatidylinositol 3-kinase/Akt pathway using LY294002 prevented cytomix-induced ERK activation and augmented cytomix-induced caspase-3 cleavage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	caspase 3	Homo sapiens	146-155
26954146-6	2016	In normal cells, both wortmannin and LY294002, PI3K inhibitors, prevented the mRNA and protein expressions of Akt and mTOR increase induced by GLP-2 (p&lt;0.01) following with the significant decreasing of occludin, claudin-1, ZO-1 mRNA and proteins expressions and TER (p&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Sus scrofa	110-113
26954146-6	2016	In normal cells, both wortmannin and LY294002, PI3K inhibitors, prevented the mRNA and protein expressions of Akt and mTOR increase induced by GLP-2 (p&lt;0.01) following with the significant decreasing of occludin, claudin-1, ZO-1 mRNA and proteins expressions and TER (p&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	mechanistic target of rapamycin kinase	Sus scrofa	118-122
26954146-6	2016	In normal cells, both wortmannin and LY294002, PI3K inhibitors, prevented the mRNA and protein expressions of Akt and mTOR increase induced by GLP-2 (p&lt;0.01) following with the significant decreasing of occludin, claudin-1, ZO-1 mRNA and proteins expressions and TER (p&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	occludin	Sus scrofa	206-214
27176825-10	2016	Additionally, IL-17A promoted resistance to daunorubicin via activation of Akt signaling and the PI3K/Akt inhibitor LY294002 or perifosine almost completely rescued daunorubicin-induced cell death in B-ALL cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	102-105
27035848-8	2016	These effects of MIF on the mCSCs were abolished by LY294002 [a phosphoinositide 3-kinase (PI3K) inhibitor] and MK-2206 (an Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	macrophage migration inhibitory factor	Homo sapiens	17-20
26833879-6	2016	In addition, a PI3K/Akt signalling pathway inhibitor (LY294002) alleviated the tumorigenic effects of FGF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	20-23
26833879-6	2016	In addition, a PI3K/Akt signalling pathway inhibitor (LY294002) alleviated the tumorigenic effects of FGF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	fibroblast growth factor 2	Homo sapiens	102-106
26855187-15	2016	AGS cells with CLEC2 knockdown had increased levels of phosphorylated AKT and glycogen synthase kinase-3 beta, increased expression of Snail, reduced levels of E-cadherin, and formed more metastases in mice than AGS cells that expressed CLEC2; these knockdown changes were prevented by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	C-type lectin domain family 1, member b	Mus musculus	15-20
26954146-6	2016	In normal cells, both wortmannin and LY294002, PI3K inhibitors, prevented the mRNA and protein expressions of Akt and mTOR increase induced by GLP-2 (p&lt;0.01) following with the significant decreasing of occludin, claudin-1, ZO-1 mRNA and proteins expressions and TER (p&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	claudin 1	Sus scrofa	216-225
26954146-6	2016	In normal cells, both wortmannin and LY294002, PI3K inhibitors, prevented the mRNA and protein expressions of Akt and mTOR increase induced by GLP-2 (p&lt;0.01) following with the significant decreasing of occludin, claudin-1, ZO-1 mRNA and proteins expressions and TER (p&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	zonula occludens 1	Sus scrofa	227-231
26884348-9	2016	Additionally, inactivation of Akt by LY294002 offset the exacerbated hypertrophic response induced by AB in TRIM32-deficient mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	thymoma viral proto-oncogene 1	Mus musculus	30-33
26884348-9	2016	Additionally, inactivation of Akt by LY294002 offset the exacerbated hypertrophic response induced by AB in TRIM32-deficient mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	tripartite motif-containing 32	Mus musculus	108-114
27060196-7	2016	The inhibition of AKT-FoxO3a signalings by a PI3K (PI3-kinase)/AKT inhibitor (LY294002) or the transfection of ERK5-siRNA led to the nuclear translocation of non-phosphorylated FoxO3a, and increased the protein expression of FasL and Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	thymoma viral proto-oncogene 1	Mus musculus	18-21
27060196-7	2016	The inhibition of AKT-FoxO3a signalings by a PI3K (PI3-kinase)/AKT inhibitor (LY294002) or the transfection of ERK5-siRNA led to the nuclear translocation of non-phosphorylated FoxO3a, and increased the protein expression of FasL and Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	forkhead box O3	Mus musculus	22-28
27060196-7	2016	The inhibition of AKT-FoxO3a signalings by a PI3K (PI3-kinase)/AKT inhibitor (LY294002) or the transfection of ERK5-siRNA led to the nuclear translocation of non-phosphorylated FoxO3a, and increased the protein expression of FasL and Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	thymoma viral proto-oncogene 1	Mus musculus	63-66
27060196-7	2016	The inhibition of AKT-FoxO3a signalings by a PI3K (PI3-kinase)/AKT inhibitor (LY294002) or the transfection of ERK5-siRNA led to the nuclear translocation of non-phosphorylated FoxO3a, and increased the protein expression of FasL and Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	forkhead box O3	Mus musculus	177-183
27060196-7	2016	The inhibition of AKT-FoxO3a signalings by a PI3K (PI3-kinase)/AKT inhibitor (LY294002) or the transfection of ERK5-siRNA led to the nuclear translocation of non-phosphorylated FoxO3a, and increased the protein expression of FasL and Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	Fas ligand (TNF superfamily, member 6)	Mus musculus	225-229
27060196-7	2016	The inhibition of AKT-FoxO3a signalings by a PI3K (PI3-kinase)/AKT inhibitor (LY294002) or the transfection of ERK5-siRNA led to the nuclear translocation of non-phosphorylated FoxO3a, and increased the protein expression of FasL and Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	BCL2-like 11 (apoptosis facilitator)	Mus musculus	234-237
26743528-7	2016	In parallel with its effect on endogenous ABCA1 mRNA levels, IGF-1 induced the activity of a reporter construct containing the ABCA1 promoter, while it was abrogated by LY294002, a specific inhibitor of PI3-K. Constitutively active Akt stimulated activity of the ABCA1 promoter, and a dominant-negative mutant of Akt or mutagenesis of the FoxO1 response element in the ABCA1 promoter abolished the ability of IGF-1 to stimulate promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	ATP binding cassette subfamily A member 1	Rattus norvegicus	42-47
26743528-7	2016	In parallel with its effect on endogenous ABCA1 mRNA levels, IGF-1 induced the activity of a reporter construct containing the ABCA1 promoter, while it was abrogated by LY294002, a specific inhibitor of PI3-K. Constitutively active Akt stimulated activity of the ABCA1 promoter, and a dominant-negative mutant of Akt or mutagenesis of the FoxO1 response element in the ABCA1 promoter abolished the ability of IGF-1 to stimulate promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	insulin-like growth factor 1	Rattus norvegicus	61-66
26743528-7	2016	In parallel with its effect on endogenous ABCA1 mRNA levels, IGF-1 induced the activity of a reporter construct containing the ABCA1 promoter, while it was abrogated by LY294002, a specific inhibitor of PI3-K. Constitutively active Akt stimulated activity of the ABCA1 promoter, and a dominant-negative mutant of Akt or mutagenesis of the FoxO1 response element in the ABCA1 promoter abolished the ability of IGF-1 to stimulate promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Rattus norvegicus	232-235
26743528-7	2016	In parallel with its effect on endogenous ABCA1 mRNA levels, IGF-1 induced the activity of a reporter construct containing the ABCA1 promoter, while it was abrogated by LY294002, a specific inhibitor of PI3-K. Constitutively active Akt stimulated activity of the ABCA1 promoter, and a dominant-negative mutant of Akt or mutagenesis of the FoxO1 response element in the ABCA1 promoter abolished the ability of IGF-1 to stimulate promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Rattus norvegicus	313-316
26743528-7	2016	In parallel with its effect on endogenous ABCA1 mRNA levels, IGF-1 induced the activity of a reporter construct containing the ABCA1 promoter, while it was abrogated by LY294002, a specific inhibitor of PI3-K. Constitutively active Akt stimulated activity of the ABCA1 promoter, and a dominant-negative mutant of Akt or mutagenesis of the FoxO1 response element in the ABCA1 promoter abolished the ability of IGF-1 to stimulate promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	forkhead box O1	Rattus norvegicus	339-344
26743528-7	2016	In parallel with its effect on endogenous ABCA1 mRNA levels, IGF-1 induced the activity of a reporter construct containing the ABCA1 promoter, while it was abrogated by LY294002, a specific inhibitor of PI3-K. Constitutively active Akt stimulated activity of the ABCA1 promoter, and a dominant-negative mutant of Akt or mutagenesis of the FoxO1 response element in the ABCA1 promoter abolished the ability of IGF-1 to stimulate promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	insulin-like growth factor 1	Rattus norvegicus	409-414
26951965-8	2016	This was further confimed by pre-treatment with the PI3K/Akt inhibitor, LY294002, which markedly attenuated the miR-214-induced increase in cell viability and resistance to apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	57-60
26951965-8	2016	This was further confimed by pre-treatment with the PI3K/Akt inhibitor, LY294002, which markedly attenuated the miR-214-induced increase in cell viability and resistance to apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	microRNA 214	Homo sapiens	112-119
27044523-9	2016	Blocking the PI3K-Akt pathway by LY294002 led to an enhancement of IL-12 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	thymoma viral proto-oncogene 1	Mus musculus	18-21
26460717-4	2016	In platelets pretreated with LY294002 or MK2206, inhibitors of PI3K/AKT pathway, and with U73122, inhibitor of phospholipase C pathway, only a partial prevention was shown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	68-71
26447680-10	2016	The treatment of LY294002 inhibited phospho-Akt (Ser 473) and phospho-Akt (Thr 308) expression followed by decreased CTGF, secretory fibronectin and secretory Col 3 in high glucose-treated HKC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	thymoma viral proto-oncogene 1	Mus musculus	44-47
26447680-10	2016	The treatment of LY294002 inhibited phospho-Akt (Ser 473) and phospho-Akt (Thr 308) expression followed by decreased CTGF, secretory fibronectin and secretory Col 3 in high glucose-treated HKC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	thymoma viral proto-oncogene 1	Mus musculus	70-73
26447680-10	2016	The treatment of LY294002 inhibited phospho-Akt (Ser 473) and phospho-Akt (Thr 308) expression followed by decreased CTGF, secretory fibronectin and secretory Col 3 in high glucose-treated HKC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	cellular communication network factor 2	Homo sapiens	117-121
26447680-10	2016	The treatment of LY294002 inhibited phospho-Akt (Ser 473) and phospho-Akt (Thr 308) expression followed by decreased CTGF, secretory fibronectin and secretory Col 3 in high glucose-treated HKC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	fibronectin 1	Homo sapiens	133-144
26460717-10	2016	The PI3K/AKT pathway and PKC participate to this PDE3A phosphorylation/activation mechanism as it was greatly inhibited by platelet pretreatment with LY294002, MK2206, U73122, or the PKC specific inhibitor GF109203X.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	AKT serine/threonine kinase 1	Homo sapiens	9-12
26460717-10	2016	The PI3K/AKT pathway and PKC participate to this PDE3A phosphorylation/activation mechanism as it was greatly inhibited by platelet pretreatment with LY294002, MK2206, U73122, or the PKC specific inhibitor GF109203X.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	phosphodiesterase 3A	Homo sapiens	49-54
25789966-8	2016	(PI3-K/AKT) inhibitor LY294002 effectively abolished MC-LR-enhanced migration and invasion and MMP-13 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Homo sapiens	7-10
26814361-10	2016	CTRP9 could inhibit cell apoptosis and eNOS expression reduction in the cells pretreated with the PI3K/Akt inhibitor LY294002 and resist LY294002-induced ET-1 and MMP-2 secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	C1q and TNF related 9	Homo sapiens	0-5
26814361-10	2016	CTRP9 could inhibit cell apoptosis and eNOS expression reduction in the cells pretreated with the PI3K/Akt inhibitor LY294002 and resist LY294002-induced ET-1 and MMP-2 secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	103-106
26814361-10	2016	CTRP9 could inhibit cell apoptosis and eNOS expression reduction in the cells pretreated with the PI3K/Akt inhibitor LY294002 and resist LY294002-induced ET-1 and MMP-2 secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	C1q and TNF related 9	Homo sapiens	0-5
26814361-10	2016	CTRP9 could inhibit cell apoptosis and eNOS expression reduction in the cells pretreated with the PI3K/Akt inhibitor LY294002 and resist LY294002-induced ET-1 and MMP-2 secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	AKT serine/threonine kinase 1	Homo sapiens	103-106
26814361-10	2016	CTRP9 could inhibit cell apoptosis and eNOS expression reduction in the cells pretreated with the PI3K/Akt inhibitor LY294002 and resist LY294002-induced ET-1 and MMP-2 secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	endothelin 1	Homo sapiens	154-158
26814361-10	2016	CTRP9 could inhibit cell apoptosis and eNOS expression reduction in the cells pretreated with the PI3K/Akt inhibitor LY294002 and resist LY294002-induced ET-1 and MMP-2 secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	matrix metallopeptidase 2	Homo sapiens	163-168
26871266-7	2016	The PI3K/AKT pathway was activated by simvastatin in this process, and LY294002 reversed the overexpression of CXCR4 caused by simvastatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	C-X-C motif chemokine receptor 4	Rattus norvegicus	111-116
26810470-8	2016	LY294002, an inhibitor of Akt activation, abolished the protective effects of miR-21-up-regulated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	26-29
26810470-8	2016	LY294002, an inhibitor of Akt activation, abolished the protective effects of miR-21-up-regulated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	microRNA 21	Homo sapiens	78-84
25789966-8	2016	(PI3-K/AKT) inhibitor LY294002 effectively abolished MC-LR-enhanced migration and invasion and MMP-13 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	matrix metallopeptidase 13	Homo sapiens	95-101
26970304-9	2016	We also found that calycosin treatment significantly stimulated Akt phosphorylation and decreased GSK-3beta and tau phosphorylation, and that these changes could be restored by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	AKT serine/threonine kinase 1	Rattus norvegicus	64-67
26970304-9	2016	We also found that calycosin treatment significantly stimulated Akt phosphorylation and decreased GSK-3beta and tau phosphorylation, and that these changes could be restored by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	glycogen synthase kinase 3 beta	Rattus norvegicus	98-107
26970304-9	2016	We also found that calycosin treatment significantly stimulated Akt phosphorylation and decreased GSK-3beta and tau phosphorylation, and that these changes could be restored by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	AKT serine/threonine kinase 1	Rattus norvegicus	186-189
26992405-11	2016	Preconditioning with LY294002 dramatically decreased Srx-1-enhanced cell resistance to SI/R injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	sulfiredoxin 1	Rattus norvegicus	53-58
26992405-12	2016	Importantly, LY294002 mitigated the inhibitory effects of Srx-1 on Deltapsim loss, cytochrome c release, caspase-9/3 activity, and the expression of Bcl-2 family.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	sulfiredoxin 1	Rattus norvegicus	58-63
26992405-12	2016	Importantly, LY294002 mitigated the inhibitory effects of Srx-1 on Deltapsim loss, cytochrome c release, caspase-9/3 activity, and the expression of Bcl-2 family.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	caspase 9	Rattus norvegicus	105-114
26992405-12	2016	Importantly, LY294002 mitigated the inhibitory effects of Srx-1 on Deltapsim loss, cytochrome c release, caspase-9/3 activity, and the expression of Bcl-2 family.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	BCL2, apoptosis regulator	Rattus norvegicus	149-154
27110775-9	2016	Inhibition of PI3K/AKT pathway by LY294002 restored chemosensitivity of smad3-deficiency cells to cisplatin in HCC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	19-22
27123039-7	2016	Moreover, LY294002, an inhibitor of Akt phosphorylation, exerted stronger inhibitory effects on RCB-mediated suppression of adipocyte differentiation, leading to the inhibition of adipocyte differentiation through the downregulation of Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	36-39
27123039-7	2016	Moreover, LY294002, an inhibitor of Akt phosphorylation, exerted stronger inhibitory effects on RCB-mediated suppression of adipocyte differentiation, leading to the inhibition of adipocyte differentiation through the downregulation of Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	236-239
27107990-9	2016	In addition, COMP-Ang1-mediated activation of Akt and c-Jun was suppressed by treating each of pharmacological inhibitors specific to phosphoinositide 3-kinase (PI3K) (LY294002 and Wortmannin) or MAPKs (PD98059, SB203580, and SP600125).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	cartilage oligomeric matrix protein	Homo sapiens	13-17
27107990-9	2016	In addition, COMP-Ang1-mediated activation of Akt and c-Jun was suppressed by treating each of pharmacological inhibitors specific to phosphoinositide 3-kinase (PI3K) (LY294002 and Wortmannin) or MAPKs (PD98059, SB203580, and SP600125).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	angiopoietin 1	Homo sapiens	18-22
27107990-9	2016	In addition, COMP-Ang1-mediated activation of Akt and c-Jun was suppressed by treating each of pharmacological inhibitors specific to phosphoinositide 3-kinase (PI3K) (LY294002 and Wortmannin) or MAPKs (PD98059, SB203580, and SP600125).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	AKT serine/threonine kinase 1	Homo sapiens	46-49
27107990-9	2016	In addition, COMP-Ang1-mediated activation of Akt and c-Jun was suppressed by treating each of pharmacological inhibitors specific to phosphoinositide 3-kinase (PI3K) (LY294002 and Wortmannin) or MAPKs (PD98059, SB203580, and SP600125).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-59
27110775-9	2016	Inhibition of PI3K/AKT pathway by LY294002 restored chemosensitivity of smad3-deficiency cells to cisplatin in HCC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	SMAD family member 3	Homo sapiens	72-77
26922319-6	2016	The inhibitor of Akt, LY294002, but not the inhibitor of ERK1/2, PD98059, suppressed the upregulation of HIF-1alpha and the proliferation of A549-H and CCL-185-H cellsin vitro Thein vivoresults confirmed that insufficient RFA could trigger the tumor growth, upregulate the HIF-1alpha expression, and activate Akt in A549 xenograft tumors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-115
26477313-11	2016	ATC cells derived from Trp53 knockout tumors had increased PI3K/AKT signaling and became resistant to Braf(V600E) inhibitor PLX4720, which could be overcome by combined treatment of PI3K inhibitor LY294002 and PLX4720.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	transformation related protein 53	Mus musculus	23-28
26477313-11	2016	ATC cells derived from Trp53 knockout tumors had increased PI3K/AKT signaling and became resistant to Braf(V600E) inhibitor PLX4720, which could be overcome by combined treatment of PI3K inhibitor LY294002 and PLX4720.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	Braf transforming gene	Mus musculus	102-107
27114702-7	2016	Moreover, Andro-induced apoptosis is enhanced by AKT-selective inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Homo sapiens	49-52
27194942-8	2016	The effects could be blocked by the addition of the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	52-81
26805466-10	2016	We also found that TXL up-regulated the expression levels of p-PDK1, p-Akt, p-c-Raf, p-BAD and down-regulated Cleaved caspase 3 expression notably, which were partially reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	pyruvate dehydrogenase kinase 1	Rattus norvegicus	63-67
26805466-10	2016	We also found that TXL up-regulated the expression levels of p-PDK1, p-Akt, p-c-Raf, p-BAD and down-regulated Cleaved caspase 3 expression notably, which were partially reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	AKT serine/threonine kinase 1	Rattus norvegicus	71-74
26805466-10	2016	We also found that TXL up-regulated the expression levels of p-PDK1, p-Akt, p-c-Raf, p-BAD and down-regulated Cleaved caspase 3 expression notably, which were partially reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	78-83
26805466-11	2016	Additionally, the increment of p-PTEN level on which LY294002 had little effect was also detected in response to TXL treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	phosphatase and tensin homolog	Rattus norvegicus	33-37
26922319-6	2016	The inhibitor of Akt, LY294002, but not the inhibitor of ERK1/2, PD98059, suppressed the upregulation of HIF-1alpha and the proliferation of A549-H and CCL-185-H cellsin vitro Thein vivoresults confirmed that insufficient RFA could trigger the tumor growth, upregulate the HIF-1alpha expression, and activate Akt in A549 xenograft tumors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Homo sapiens	17-20
26922319-6	2016	The inhibitor of Akt, LY294002, but not the inhibitor of ERK1/2, PD98059, suppressed the upregulation of HIF-1alpha and the proliferation of A549-H and CCL-185-H cellsin vitro Thein vivoresults confirmed that insufficient RFA could trigger the tumor growth, upregulate the HIF-1alpha expression, and activate Akt in A549 xenograft tumors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	273-283
26922319-6	2016	The inhibitor of Akt, LY294002, but not the inhibitor of ERK1/2, PD98059, suppressed the upregulation of HIF-1alpha and the proliferation of A549-H and CCL-185-H cellsin vitro Thein vivoresults confirmed that insufficient RFA could trigger the tumor growth, upregulate the HIF-1alpha expression, and activate Akt in A549 xenograft tumors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Homo sapiens	309-312
26921637-7	2016	Combined treatment with phosphatidylinositol 3-kinase (PI3K) inhibitors (LY294002 or wortmannin) further decreased the Rad51 expression in astaxanthin-exposed A549 and H1703 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	RAD51 recombinase	Homo sapiens	119-124
26921637-8	2016	Knockdown of Rad51 expression by transfection with si-Rad51 RNA or cotreatment with LY294002 further enhanced the cytotoxicity and cell growth inhibition of astaxanthin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	RAD51 recombinase	Homo sapiens	13-18
26829882-15	2016	Moreover, application of the PI3K inhibitor LY294002 together with Bay11-7082 maintained normal cell migration and knocking-down PI3K (p110alpha) by a specific siRNA inhibited JNKs phosphorylation while maintaining normal IkappaBalpha phosphorylation, indicating that PI3K and NF-kappaB signaling independently regulate JNKs activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	135-144
26365534-10	2016	Inhibiting PI3K/Akt with LY294002 reactivated GSK-3beta and suppressed ketamine-enhanced permeability, EPCs, and motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	glycogen synthase kinase 3 beta	Canis lupus familiaris	46-55
26820593-8	2016	Targeting the PI3K/Akt pathway by its specific inhibitor LY294002, or by Akt small interfering RNA (siRNA) resulted in reduced capacity in invasion of FTC-238.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	19-22
26667900-4	2016	The results demonstrate that Lep activates phosphorylation of protein kinase B (Akt) and signal transducer and activator of transcription 3 in rainbow trout hypothalamus-derived cells, and that the phosphatidylinositol-3-kinase (Pi3k) inhibitor LY294002 can suppress the Lep-induced Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	leptin	Oncorhynchus mykiss	29-32
26667900-8	2016	Furthermore, ICV Lep treatment increases phosphor-Akt-immunoreactive cells in the nucleus lateralis tuberis, periventricular zone along infundibulum, and lateral recess surrounded by nucleus anterior tuberis, while LY294002 inhibits this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	leptin	Oncorhynchus mykiss	17-20
26746861-11	2016	PI3K inhibitor LY294002 or Akt inhibitor MK-2206 abolished the effects of relaxin-2 on the RSNA, MAP and plasma NE, and attenuated the relaxin-2-induced AVP secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	relaxin 2	Homo sapiens	74-83
26746861-11	2016	PI3K inhibitor LY294002 or Akt inhibitor MK-2206 abolished the effects of relaxin-2 on the RSNA, MAP and plasma NE, and attenuated the relaxin-2-induced AVP secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	relaxin 2	Homo sapiens	135-144
26887589-10	2016	To determine whether the conditioned rewarding effects of phentermine were mediated through the PI3K/Akt pathway, we assessed the effects of the Akt inhibitor LY294002 on phentermine-induced place preference and climbing behavior.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	thymoma viral proto-oncogene 1	Mus musculus	145-148
26887589-14	2016	Further, LY294002 decreased the phentermine-increased levels of DAT protein and phosphorylation of Akt in the NAc of CPP mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	64-67
26887589-14	2016	Further, LY294002 decreased the phentermine-increased levels of DAT protein and phosphorylation of Akt in the NAc of CPP mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	thymoma viral proto-oncogene 1	Mus musculus	99-102
26822343-6	2016	The TLR2 neutralization antibody and LY294002 both reduced the MMC proliferation levels induced by HMGB1 and also blocked the HMGB1-dependent phosphorylation of the Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	high mobility group box 1	Mus musculus	99-104
26822343-6	2016	The TLR2 neutralization antibody and LY294002 both reduced the MMC proliferation levels induced by HMGB1 and also blocked the HMGB1-dependent phosphorylation of the Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	high mobility group box 1	Mus musculus	126-131
26822343-6	2016	The TLR2 neutralization antibody and LY294002 both reduced the MMC proliferation levels induced by HMGB1 and also blocked the HMGB1-dependent phosphorylation of the Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	thymoma viral proto-oncogene 1	Mus musculus	165-168
27470628-8	2016	RESULTS: LY294002 was capable of reducing the proportion of CD90(+) HCC stem cells from 2.98%+-0.08% to 0.78%+-0.08% (t = 32.400, P &lt; 0.01) and reducing the clonogenicity of CD90(+) subpopulation from 95.13%+-3.78% to 61.82%+-7.23% (t = 7.617, P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	Thy-1 cell surface antigen	Homo sapiens	177-181
27352501-15	2016	The expression of Akt mRNA in the LY294002 group and acupoint combination + LY294002 group was reduced (P &lt; 0.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
27352501-15	2016	The expression of Akt mRNA in the LY294002 group and acupoint combination + LY294002 group was reduced (P &lt; 0.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
26686574-8	2016	Inhibition of Pi3K/Akt pathway with LY294002 or silencing of Nrf2 expression partially blocked the reversal of redox impairment induced by CA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	19-22
27470628-10	2016	LY294002 also reduced the tumorigenicity of CD90(+) subpopulation and the expression of CD90, SHP2, and P-AKT in related HCC stem cells, but it did not significantly affect the expression of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Thy-1 cell surface antigen	Homo sapiens	44-48
27470628-10	2016	LY294002 also reduced the tumorigenicity of CD90(+) subpopulation and the expression of CD90, SHP2, and P-AKT in related HCC stem cells, but it did not significantly affect the expression of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Thy-1 cell surface antigen	Homo sapiens	88-92
27470628-2	2016	METHODS: MHCC-97H cultures were treated with the PI3K/AKT pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	54-57
27470628-8	2016	RESULTS: LY294002 was capable of reducing the proportion of CD90(+) HCC stem cells from 2.98%+-0.08% to 0.78%+-0.08% (t = 32.400, P &lt; 0.01) and reducing the clonogenicity of CD90(+) subpopulation from 95.13%+-3.78% to 61.82%+-7.23% (t = 7.617, P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	Thy-1 cell surface antigen	Homo sapiens	60-64
27470628-10	2016	LY294002 also reduced the tumorigenicity of CD90(+) subpopulation and the expression of CD90, SHP2, and P-AKT in related HCC stem cells, but it did not significantly affect the expression of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	94-98
27470628-10	2016	LY294002 also reduced the tumorigenicity of CD90(+) subpopulation and the expression of CD90, SHP2, and P-AKT in related HCC stem cells, but it did not significantly affect the expression of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	106-109
27007368-8	2016	LY294002, a PI3K/Akt inhibitor, inhibited isoquercitrin-induced GSK3beta phosphorylation and increase of Mcl-1 expression, which indicated that regulation of isoquercitrin on Mcl-1 expression was likely related to the modulation of Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	17-20
26934554-9	2016	VEGF activated CRMP4 expression in gastric cancer cells, and this effect was significantly inhibited by MAPK and PI3K inhibitors (PD98059 and LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	vascular endothelial growth factor A	Homo sapiens	0-4
26934554-9	2016	VEGF activated CRMP4 expression in gastric cancer cells, and this effect was significantly inhibited by MAPK and PI3K inhibitors (PD98059 and LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	dihydropyrimidinase like 3	Homo sapiens	15-20
26934554-9	2016	VEGF activated CRMP4 expression in gastric cancer cells, and this effect was significantly inhibited by MAPK and PI3K inhibitors (PD98059 and LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	mitogen-activated protein kinase 1	Homo sapiens	104-108
27007368-8	2016	LY294002, a PI3K/Akt inhibitor, inhibited isoquercitrin-induced GSK3beta phosphorylation and increase of Mcl-1 expression, which indicated that regulation of isoquercitrin on Mcl-1 expression was likely related to the modulation of Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Homo sapiens	64-72
27007368-8	2016	LY294002, a PI3K/Akt inhibitor, inhibited isoquercitrin-induced GSK3beta phosphorylation and increase of Mcl-1 expression, which indicated that regulation of isoquercitrin on Mcl-1 expression was likely related to the modulation of Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	105-110
27007368-8	2016	LY294002, a PI3K/Akt inhibitor, inhibited isoquercitrin-induced GSK3beta phosphorylation and increase of Mcl-1 expression, which indicated that regulation of isoquercitrin on Mcl-1 expression was likely related to the modulation of Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	175-180
27007368-8	2016	LY294002, a PI3K/Akt inhibitor, inhibited isoquercitrin-induced GSK3beta phosphorylation and increase of Mcl-1 expression, which indicated that regulation of isoquercitrin on Mcl-1 expression was likely related to the modulation of Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	232-235
26962868-15	2016	Moreover, cytoprotection mediated by clusterin was partially abrogated by Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	clusterin	Rattus norvegicus	37-46
27003207-7	2016	This protective effect correlates with the inability of Abeta to activate GSK3beta, is mimicked by GSK3beta inhibition with SB126763 (in slices obtained from sedentary mice), and is abolished by the inhibition of PI3K with LY294002 (in slices obtained from mice that exercised).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	223-231	glycogen synthase kinase 3 beta	Mus musculus	99-107
26811873-3	2016	Fifty-four compounds were detected, and the contents of metabolites from the citric acid cycle increased in response to the insulin treatment for 4 h, which was sensitive to U0126 and LY294002, inhibitors for mitogen-activated protein kinase kinase-1 and phosphoinositide 3-kinase, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	insulin	Homo sapiens	124-131
26811873-7	2016	The contents of free amino acids were slightly decreased by the insulin treatment, while the co-treatment with U0126 and LY294002 abrogated these insulin-mediated decreases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	insulin	Homo sapiens	146-153
26962868-15	2016	Moreover, cytoprotection mediated by clusterin was partially abrogated by Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
26853763-10	2016	Furthermore, the pretreatment of LY294002 (PI3K inhibitors) or PD98059 (ERK1/2 inhibitor) blocked apelin-13-mediated activities in FS-stressed rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	apelin	Rattus norvegicus	98-104
26956674-11	2016	Carbachol-induced ASM cell migration was reduced by selective inhibitors of PI3K/Akt (LY294002) and p38 (SB203580), suggesting that it occurred through p38 and Akt phosphorylation, which was inhibited by the M3 mAChR antagonist 4-DAMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	mitogen-activated protein kinase 14	Homo sapiens	152-155
26721419-8	2016	The AMPK activator AICAR and the PI3K inhibitor LY294002 dramatically abrogated both chemerin secretion and gene expression, and further potentiated the inhibitory effect of alpha-LA on chemerin secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	retinoic acid receptor responder 2	Homo sapiens	85-93
26721419-8	2016	The AMPK activator AICAR and the PI3K inhibitor LY294002 dramatically abrogated both chemerin secretion and gene expression, and further potentiated the inhibitory effect of alpha-LA on chemerin secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	retinoic acid receptor responder 2	Homo sapiens	186-194
26955235-6	2016	By using rapamycin, LY294002, and NVP-BEZ235, respectively, PI3K and mTOR signals were blocked independently or dually in colorectal CSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mechanistic target of rapamycin kinase	Homo sapiens	69-73
27007909-5	2016	Additionally, in duck myoblasts treated with LY294002 and rapamycin, the specific inhibitors ofPI3K and mTOR, respectively, the overexpression of Six1 could significantly ameliorate inhibitive effects of these inhibitors on protein synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	mechanistic target of rapamycin kinase	Homo sapiens	104-108
27007909-5	2016	Additionally, in duck myoblasts treated with LY294002 and rapamycin, the specific inhibitors ofPI3K and mTOR, respectively, the overexpression of Six1 could significantly ameliorate inhibitive effects of these inhibitors on protein synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	SIX homeobox 1	Homo sapiens	146-150
26821334-13	2016	However, this inductive effect was blunted in the presence of the AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	66-69
26800397-6	2016	Blocking the activation of Akt with LY294002 or mTOR with rapamycin significantly prevented miR-222-induced proliferation and restored the sensitivity of bladder cancer cells to cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	27-30
26800397-6	2016	Blocking the activation of Akt with LY294002 or mTOR with rapamycin significantly prevented miR-222-induced proliferation and restored the sensitivity of bladder cancer cells to cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	microRNA 222	Homo sapiens	92-99
26647806-11	2016	The PI3K inhibitor, LY294002, reversed the activation of the Akt/CDC2/survivin cascade in the Smad4-deficient cells, while it had little effect on cells with high Smad4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	thymoma viral proto-oncogene 1	Mus musculus	61-64
26608166-6	2016	Treatment of cells with known pharmacological inhibitors of ERK1/2 (PD98059), p38 (SB203580), and Akt (LY294002) confirmed the association of these signaling pathways with the observed alterations in COX-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	AKT serine/threonine kinase 1	Bos taurus	98-101
26608166-6	2016	Treatment of cells with known pharmacological inhibitors of ERK1/2 (PD98059), p38 (SB203580), and Akt (LY294002) confirmed the association of these signaling pathways with the observed alterations in COX-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	prostaglandin-endoperoxide synthase 2	Bos taurus	200-205
26899709-10	2016	Furthermore, the protective effects of FGF-2 were abolished by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	fibroblast growth factor 2	Rattus norvegicus	39-44
26899709-10	2016	Furthermore, the protective effects of FGF-2 were abolished by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Rattus norvegicus	68-71
26859575-5	2016	LY294002, a PI-3 kinase inhibitor, and a c-Met inhibitor inhibited the motility and invasiveness of Gli1-transfected KAT-18 cells more effectively than the vector-transfected cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GLI family zinc finger 1	Homo sapiens	100-104
26647806-11	2016	The PI3K inhibitor, LY294002, reversed the activation of the Akt/CDC2/survivin cascade in the Smad4-deficient cells, while it had little effect on cells with high Smad4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	cyclin-dependent kinase 1	Mus musculus	65-69
26647806-11	2016	The PI3K inhibitor, LY294002, reversed the activation of the Akt/CDC2/survivin cascade in the Smad4-deficient cells, while it had little effect on cells with high Smad4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	baculoviral IAP repeat-containing 5	Mus musculus	70-78
26647806-11	2016	The PI3K inhibitor, LY294002, reversed the activation of the Akt/CDC2/survivin cascade in the Smad4-deficient cells, while it had little effect on cells with high Smad4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	SMAD family member 4	Mus musculus	94-99
26647806-11	2016	The PI3K inhibitor, LY294002, reversed the activation of the Akt/CDC2/survivin cascade in the Smad4-deficient cells, while it had little effect on cells with high Smad4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	SMAD family member 4	Mus musculus	163-168
26647806-13	2016	The present study also implies that LY294002 has potential therapeutic value to reverse the chemosensitivity of CRC with low Smad4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	SMAD family member 4	Mus musculus	125-130
26677144-8	2016	In order to explore the mechanism of CA-induced apoptosis, insulin-like growth factor-1 (IGF-1) and PI3K inhibitor (LY294002) were used to regulate the phosphoinositide 3-kinase (PI3K)/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	152-177
26824621-6	2016	The Danggui Buxue Tang-induced phosphorylation of endothelial nitric oxide synthase and Akt kinase in human umbilical vein endothelial cells were fully blocked by treatment with an endothelial nitric oxide synthase inhibitor (L-NAME), a PI3K/Akt inhibitor (LY294002), and a Ca(2+) chelator (BAPTA-AM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	257-265	nitric oxide synthase 3	Homo sapiens	50-83
26824621-6	2016	The Danggui Buxue Tang-induced phosphorylation of endothelial nitric oxide synthase and Akt kinase in human umbilical vein endothelial cells were fully blocked by treatment with an endothelial nitric oxide synthase inhibitor (L-NAME), a PI3K/Akt inhibitor (LY294002), and a Ca(2+) chelator (BAPTA-AM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	257-265	AKT serine/threonine kinase 1	Homo sapiens	88-91
26824621-6	2016	The Danggui Buxue Tang-induced phosphorylation of endothelial nitric oxide synthase and Akt kinase in human umbilical vein endothelial cells were fully blocked by treatment with an endothelial nitric oxide synthase inhibitor (L-NAME), a PI3K/Akt inhibitor (LY294002), and a Ca(2+) chelator (BAPTA-AM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	257-265	nitric oxide synthase 3	Homo sapiens	181-214
26482612-6	2016	Importantly, gefitinib sensitivity was decreased by the upregulation of miR-221, which was blocked by pcDNA-PTEN co-transfection or by the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	microRNA 221	Homo sapiens	72-79
27042221-12	2016	Furthermore, downregulation of p-Akt by LY294002 reversed the DDP resistance induced by BRE by increasing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	BRISC and BRCA1 A complex member 2	Homo sapiens	88-91
26482612-6	2016	Importantly, gefitinib sensitivity was decreased by the upregulation of miR-221, which was blocked by pcDNA-PTEN co-transfection or by the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	phosphatase and tensin homolog	Homo sapiens	108-112
26482612-6	2016	Importantly, gefitinib sensitivity was decreased by the upregulation of miR-221, which was blocked by pcDNA-PTEN co-transfection or by the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	139-168
26915319-7	2016	Luteolin, LY294002 (an inhibitor of Akt signaling) and PD98059 (an inhibitor of Erk1/2 signaling) could inhibit the expression of p-Akt and p-Erk1/2 respectively in MCF-7 cells induced by EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	36-39
27551507-7	2016	Moreover, treatment with Ly294002, an inhibitor of AKT phosphorylation, further promoted GADD45alpha gene transcription in both non-light and light-damaged ARPE-19 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	growth arrest and DNA damage inducible alpha	Homo sapiens	89-100
26774220-5	2016	These neuroprotective effects could be blocked by the PI3-K/Akt inhibitor LY294002, indicating the involvement of PI3-K/Akt activation in the therapeutic action.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	60-63
26774220-5	2016	These neuroprotective effects could be blocked by the PI3-K/Akt inhibitor LY294002, indicating the involvement of PI3-K/Akt activation in the therapeutic action.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	120-123
26915319-7	2016	Luteolin, LY294002 (an inhibitor of Akt signaling) and PD98059 (an inhibitor of Erk1/2 signaling) could inhibit the expression of p-Akt and p-Erk1/2 respectively in MCF-7 cells induced by EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	132-135
26775845-11	2016	PlGF induced PI3K/Akt phosphorylation in HIMECs and pretreatment of PlGF-stimulated HIMECs with PI3K inhibitor (LY294002) significantly inhibited the PlGF-induced cell migration and tube formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	placental growth factor	Homo sapiens	0-4
26915319-7	2016	Luteolin, LY294002 (an inhibitor of Akt signaling) and PD98059 (an inhibitor of Erk1/2 signaling) could inhibit the expression of p-Akt and p-Erk1/2 respectively in MCF-7 cells induced by EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	mitogen-activated protein kinase 3	Homo sapiens	142-148
26909550-11	2016	However, when co-administrating LY294002, an inhibitor of PI3K/AKT pathway, an increased apoptosis was observed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	63-66
26775845-11	2016	PlGF induced PI3K/Akt phosphorylation in HIMECs and pretreatment of PlGF-stimulated HIMECs with PI3K inhibitor (LY294002) significantly inhibited the PlGF-induced cell migration and tube formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Homo sapiens	18-21
26775845-11	2016	PlGF induced PI3K/Akt phosphorylation in HIMECs and pretreatment of PlGF-stimulated HIMECs with PI3K inhibitor (LY294002) significantly inhibited the PlGF-induced cell migration and tube formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	placental growth factor	Homo sapiens	68-72
26775845-11	2016	PlGF induced PI3K/Akt phosphorylation in HIMECs and pretreatment of PlGF-stimulated HIMECs with PI3K inhibitor (LY294002) significantly inhibited the PlGF-induced cell migration and tube formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	placental growth factor	Homo sapiens	68-72
26786697-6	2016	All these effects were inhibited by zinc protoporphyrin IX (ZnPP), an inhibitor of HO-1, and LY294002, an inhibitor of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Rattus norvegicus	119-122
26786697-7	2016	Moreover, TMP inhibited the decrease of mRNA expression of HO-1 which was suppressed by ZnPP and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	heme oxygenase 1	Rattus norvegicus	59-63
26786697-8	2016	TMP inhibited the decrease of Akt phosphorylation in rats after SCI, which was suppressed by LY294002, but not ZnPP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Rattus norvegicus	30-33
26786697-9	2016	Furthermore, LY294002, but not ZnPP, significantly inhibited TMP-induced increase of mRNA expression of Nrf2 and DNA binding activity of Nrf2 in HO-1 promoters in rat model of SCI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	104-108
26786697-9	2016	Furthermore, LY294002, but not ZnPP, significantly inhibited TMP-induced increase of mRNA expression of Nrf2 and DNA binding activity of Nrf2 in HO-1 promoters in rat model of SCI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	137-141
26786697-9	2016	Furthermore, LY294002, but not ZnPP, significantly inhibited TMP-induced increase of mRNA expression of Nrf2 and DNA binding activity of Nrf2 in HO-1 promoters in rat model of SCI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	heme oxygenase 1	Rattus norvegicus	145-149
26747727-9	2016	This event was largely abolished by LY294002 pre-treatment, suggesting that ATRA and Wnt3A at least partially promote osteogenic differentiation via activating the PI3K/AKT/GSK3beta signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	Wnt family member 3A	Homo sapiens	85-90
26747727-9	2016	This event was largely abolished by LY294002 pre-treatment, suggesting that ATRA and Wnt3A at least partially promote osteogenic differentiation via activating the PI3K/AKT/GSK3beta signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	169-172
26747727-9	2016	This event was largely abolished by LY294002 pre-treatment, suggesting that ATRA and Wnt3A at least partially promote osteogenic differentiation via activating the PI3K/AKT/GSK3beta signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	glycogen synthase kinase 3 beta	Homo sapiens	173-181
26796279-9	2016	The combination of LY294002, PI3K inhibitor, and curcumin induced cell cycle arrest by decreasing CDK4, CDK2 and cyclin E2 in Bcl-2+ MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	cyclin dependent kinase 4	Homo sapiens	98-102
26490311-12	2016	In HEK293T cells with stable expression of H1968Y or P2213S mTOR mutants, LY294002 and AZD5363 showed higher potency than temsirolimus or BYL719 in inhibiting the PI3K-AKT-mTOR pathway and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	mechanistic target of rapamycin kinase	Homo sapiens	60-64
26490311-12	2016	In HEK293T cells with stable expression of H1968Y or P2213S mTOR mutants, LY294002 and AZD5363 showed higher potency than temsirolimus or BYL719 in inhibiting the PI3K-AKT-mTOR pathway and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	mechanistic target of rapamycin kinase	Homo sapiens	172-176
26877709-8	2016	Moreover, melatonin increased PI3K/Akt activation, LY294002 abrogated HSP27 activation and promoted cell apoptosis induced by melatonin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	heat shock protein family B (small) member 1	Homo sapiens	70-75
26632606-9	2016	Inhibition of the phosphatidylinositol 3-kinase cascade with LY294002 (20 muM) abolished action of insulin on Kir4.1/5.1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	110-116
26796279-10	2016	Moreover, LY294002 further inhibited the phosphorylation of Akt in Bcl-2+ MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	60-63
26796279-9	2016	The combination of LY294002, PI3K inhibitor, and curcumin induced cell cycle arrest by decreasing CDK4, CDK2 and cyclin E2 in Bcl-2+ MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	cyclin dependent kinase 2	Homo sapiens	104-108
26796279-10	2016	Moreover, LY294002 further inhibited the phosphorylation of Akt in Bcl-2+ MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	BCL2 apoptosis regulator	Homo sapiens	67-72
26796279-9	2016	The combination of LY294002, PI3K inhibitor, and curcumin induced cell cycle arrest by decreasing CDK4, CDK2 and cyclin E2 in Bcl-2+ MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	cyclin E2	Homo sapiens	113-122
26796279-9	2016	The combination of LY294002, PI3K inhibitor, and curcumin induced cell cycle arrest by decreasing CDK4, CDK2 and cyclin E2 in Bcl-2+ MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	BCL2 apoptosis regulator	Homo sapiens	126-131
26818151-13	2016	Inhibition of the signalling pathway with AMD3100 and LY294002 subsequently reduced progesterone-induced CXCL12/CXCR4/PI3K/pAkt signalling activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	C-X-C motif chemokine ligand 12	Rattus norvegicus	105-111
26818151-13	2016	Inhibition of the signalling pathway with AMD3100 and LY294002 subsequently reduced progesterone-induced CXCL12/CXCR4/PI3K/pAkt signalling activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	C-X-C motif chemokine receptor 4	Rattus norvegicus	112-117
26621495-16	2016	Inhibition of H9c2 cell apoptosis induced by HPC and SphK2 overexpression was abolished by PI3K/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	sphingosine kinase 2	Rattus norvegicus	53-58
26621495-16	2016	Inhibition of H9c2 cell apoptosis induced by HPC and SphK2 overexpression was abolished by PI3K/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	G protein-coupled estrogen receptor 1	Homo sapiens	21-58
26608500-11	2016	Furthermore, the expression of COX-2 was attenuated by both Akt inhibitor (LY294002) and ERK inhibitor (U0126), and IkappaBalpha degradation was suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	31-36
26608500-11	2016	Furthermore, the expression of COX-2 was attenuated by both Akt inhibitor (LY294002) and ERK inhibitor (U0126), and IkappaBalpha degradation was suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	AKT serine/threonine kinase 1	Homo sapiens	60-63
26608500-11	2016	Furthermore, the expression of COX-2 was attenuated by both Akt inhibitor (LY294002) and ERK inhibitor (U0126), and IkappaBalpha degradation was suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	prostaglandin-endoperoxide synthase 2	Homo sapiens	31-36
26608500-11	2016	Furthermore, the expression of COX-2 was attenuated by both Akt inhibitor (LY294002) and ERK inhibitor (U0126), and IkappaBalpha degradation was suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	NFKB inhibitor alpha	Homo sapiens	116-128
26371948-7	2016	Furthermore, silencing of raptor and rictor using shRNA adenoviral vectors to suppress mTORC1 and mTORC2, respectively, or blocking phosphatidylinositol 3-kinase (PI3K) signaling with LY294002 (LY) or Akt signaling by dominant-negative Akt expression caused a substantial increase in PE-stimulated CTGF expression as measured by both mRNA and secreted protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	132-161
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	G protein-coupled estrogen receptor 1	Homo sapiens	60-64
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	AKT serine/threonine kinase 1	Homo sapiens	138-141
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	homeobox D13	Homo sapiens	156-159
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	matrix metallopeptidase 9	Homo sapiens	187-192
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	G protein-coupled estrogen receptor 1	Homo sapiens	244-248
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	AKT serine/threonine kinase 1	Homo sapiens	280-283
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	homeobox D13	Homo sapiens	334-337
26648172-8	2016	LY294002 was found to eliminate the effects of intravenous HMGB1 on myocardial I/R injury (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	high mobility group box 1	Rattus norvegicus	59-64
26647727-5	2016	Neurite outgrowth and neuronal survival induced by senegenin were significantly inhibited by A2A receptor antagonist ZM241385 and specific phosphoinositide-3 kinase (PI3K) inhibitor LY294002, but not by tropomyosin receptor kinase A receptor inhibitor K252a, mitogen-activated protein kinase kinase inhibitor PD98059 or protein kinase C inhibitor GO6976.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	139-164
26719016-8	2016	LY294002 was used to specifically block the phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homologue (PI3K/Akt) pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	76-79
26647727-6	2016	Furthermore, senegenin enhanced the phosphorylation of Akt, which was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Rattus norvegicus	55-58
26647778-6	2016	Treatment of with LY294002 (20 microM) inhibited the activation of Akt and mTOR and effectively prevented TGF-beta2-induced EMT in the HLECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	67-70
26647778-6	2016	Treatment of with LY294002 (20 microM) inhibited the activation of Akt and mTOR and effectively prevented TGF-beta2-induced EMT in the HLECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	mechanistic target of rapamycin kinase	Homo sapiens	75-79
26647778-6	2016	Treatment of with LY294002 (20 microM) inhibited the activation of Akt and mTOR and effectively prevented TGF-beta2-induced EMT in the HLECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	transforming growth factor beta 2	Homo sapiens	106-115
26660506-11	2016	GnRH treatment increased RUNX2 mRNA and protein levels in HTR-8/SVneo cells and primary EVTs, and these effects were attenuated by co-treatment with Antide, PD98095 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	gonadotropin releasing hormone 1	Homo sapiens	0-4
26660506-11	2016	GnRH treatment increased RUNX2 mRNA and protein levels in HTR-8/SVneo cells and primary EVTs, and these effects were attenuated by co-treatment with Antide, PD98095 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	RUNX family transcription factor 2	Homo sapiens	25-30
26717963-6	2016	In addition, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor, LY294002, was employed to illustrate the mechanism of the antiapoptotic effect of GLP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	15-61
26717963-6	2016	In addition, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor, LY294002, was employed to illustrate the mechanism of the antiapoptotic effect of GLP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	glucagon	Rattus norvegicus	162-167
26717963-10	2016	GLP-1 reversed the above changes induced by AOPPs and the protective effects of GLP-1 were abolished by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	glucagon	Rattus norvegicus	0-5
26717963-10	2016	GLP-1 reversed the above changes induced by AOPPs and the protective effects of GLP-1 were abolished by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	glucagon	Rattus norvegicus	80-85
26719016-8	2016	LY294002 was used to specifically block the phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homologue (PI3K/Akt) pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	126-129
26719016-10	2016	The application of LY294002 restored the migration and invasion abilities of the LoVo cells bearing CHRNA7.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	cholinergic receptor nicotinic alpha 7 subunit	Homo sapiens	100-106
26687633-9	2016	Finally, IGF-1-induced increase in nuclear Nrf2 protein and GCLM mRNA expression was abolished by LY294002, a phosphoinositide 3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	insulin like growth factor 1	Homo sapiens	9-14
26706460-8	2016	Spermatogonia were treated with the specific PI3K inhibitor LY294002, and p70s6k, rps6 and 4ebp1 phosphorylation overtly decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	ribosomal protein S6	Rattus norvegicus	82-96
26840295-8	2016	Moreover, Rd upregulated the expression of GAP-43, a neuron-specific protein involved in neurite outgrowth, while PD98059 or/and LY294002 decreased Rd-induced increased GAP-43 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	growth associated protein 43	Rattus norvegicus	169-175
26840295-7	2016	We also showed that Rd activated ERK1/2 and AKT but not PKC signalings, and inhibition of ERK1/2 by PD98059 or/and AKT by LY294002 effectively attenuated Rd-induced neurite outgrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	mitogen activated protein kinase 3	Rattus norvegicus	33-39
26840295-7	2016	We also showed that Rd activated ERK1/2 and AKT but not PKC signalings, and inhibition of ERK1/2 by PD98059 or/and AKT by LY294002 effectively attenuated Rd-induced neurite outgrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	mitogen activated protein kinase 3	Rattus norvegicus	90-96
26840295-7	2016	We also showed that Rd activated ERK1/2 and AKT but not PKC signalings, and inhibition of ERK1/2 by PD98059 or/and AKT by LY294002 effectively attenuated Rd-induced neurite outgrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Rattus norvegicus	115-118
26687633-9	2016	Finally, IGF-1-induced increase in nuclear Nrf2 protein and GCLM mRNA expression was abolished by LY294002, a phosphoinositide 3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
26687633-9	2016	Finally, IGF-1-induced increase in nuclear Nrf2 protein and GCLM mRNA expression was abolished by LY294002, a phosphoinositide 3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	glutamate-cysteine ligase modifier subunit	Homo sapiens	60-64
26687945-8	2016	LY294002 and BMP4 completely abolish cytoprotective role of FSTL1 against SNP challenge, indicating both activation of Akt and inhibition of BMP/Smad1/5/9 signaling are involved in this cellular process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	follistatin-like 1	Rattus norvegicus	60-65
26687945-8	2016	LY294002 and BMP4 completely abolish cytoprotective role of FSTL1 against SNP challenge, indicating both activation of Akt and inhibition of BMP/Smad1/5/9 signaling are involved in this cellular process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	119-122
26687945-8	2016	LY294002 and BMP4 completely abolish cytoprotective role of FSTL1 against SNP challenge, indicating both activation of Akt and inhibition of BMP/Smad1/5/9 signaling are involved in this cellular process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	SMAD family member 1	Rattus norvegicus	145-152
26655814-9	2016	The phosphoinositide 3-kinase (PI3K) inhibitor LY294002 blocked the effects of GLP-1 on channel activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	glucagon	Rattus norvegicus	79-84
26620226-8	2016	The inhibitors LY294002 (PI3K-AKT inhibitor), U0126 (inhibitor of ERK1/2) and rapamycin (mTOR inhibitor) also blocked the ability of EGF to increase HIF-1alpha protein and to phosphorylate AKT, ERK1/2 and mTOR proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	30-33
26788032-9	2016	U0126 decreased the phosphorylation of ERK1/2, and LY294002 decreased the phosphorylation of AKT; each could significantly inhibit LDR-induced 2BS cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	93-96
26620226-8	2016	The inhibitors LY294002 (PI3K-AKT inhibitor), U0126 (inhibitor of ERK1/2) and rapamycin (mTOR inhibitor) also blocked the ability of EGF to increase HIF-1alpha protein and to phosphorylate AKT, ERK1/2 and mTOR proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	epidermal growth factor	Homo sapiens	133-136
26620226-8	2016	The inhibitors LY294002 (PI3K-AKT inhibitor), U0126 (inhibitor of ERK1/2) and rapamycin (mTOR inhibitor) also blocked the ability of EGF to increase HIF-1alpha protein and to phosphorylate AKT, ERK1/2 and mTOR proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-159
26746999-6	2016	Pretreatment with the androgen receptor antagonist flutamide, the phosphatidylinositol 3 kinase inhibitor LY294002, and the nitric oxide synthase inhibitor L-NG-nitroarginine methyl ester abrogated the reduction in senescence and the normalization of telomere binding factor 2 levels attained by testosterone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	transcription termination factor 2	Homo sapiens	268-276
27822469-7	2016	Furthermore, using the PI3K/AKT pathway blocker LY294002, we confirmed that the PI3K/AKT pathway was involved in mediating these effects of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	28-31
26506538-7	2016	And, PI3K/Akt inhibitor (LY294002) blocked MC-LR-induced Akt/S6K1 activation and proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	10-13
26506538-7	2016	And, PI3K/Akt inhibitor (LY294002) blocked MC-LR-induced Akt/S6K1 activation and proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	57-60
26506538-7	2016	And, PI3K/Akt inhibitor (LY294002) blocked MC-LR-induced Akt/S6K1 activation and proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	ribosomal protein S6 kinase B1	Homo sapiens	61-65
26492523-11	2016	Aspirin, U0126, LY294002 and 5z-7-oxozeaenol attenuated the IL-1beta-induced MCP-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	interleukin 1 beta	Homo sapiens	60-68
26492523-11	2016	Aspirin, U0126, LY294002 and 5z-7-oxozeaenol attenuated the IL-1beta-induced MCP-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	C-C motif chemokine ligand 2	Homo sapiens	77-82
26492523-12	2016	In addition, 5z-7-oxozeaenol, LY294002, U0126 and aspirin prevented the IL-1beta-induced MCP-1 secretion of pulp cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	interleukin 1 beta	Mus musculus	72-80
26492523-12	2016	In addition, 5z-7-oxozeaenol, LY294002, U0126 and aspirin prevented the IL-1beta-induced MCP-1 secretion of pulp cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	mast cell protease 1	Mus musculus	89-94
26830479-5	2016	Cells were also treated with an Akt inhibitor, LY294002, to examine the mechanism of the protective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	32-35
26520032-9	2016	20 muM of LY294002 decreased FGF4-induced p-AKT, p-P90RSK and p-RPS6 proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	fibroblast growth factor 4	Sus scrofa	29-33
26520032-9	2016	20 muM of LY294002 decreased FGF4-induced p-AKT, p-P90RSK and p-RPS6 proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Sus scrofa	44-47
26520032-9	2016	20 muM of LY294002 decreased FGF4-induced p-AKT, p-P90RSK and p-RPS6 proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	ribosomal protein S6	Sus scrofa	64-68
26520032-10	2016	Immunofluorescence analyses revealed that p-RPS6 proteins were abundant within the cytoplasm of FGF4-treated cells, but present at basal levels in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	ribosomal protein S6	Sus scrofa	44-48
27822469-7	2016	Furthermore, using the PI3K/AKT pathway blocker LY294002, we confirmed that the PI3K/AKT pathway was involved in mediating these effects of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	85-88
27822469-7	2016	Furthermore, using the PI3K/AKT pathway blocker LY294002, we confirmed that the PI3K/AKT pathway was involved in mediating these effects of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	phosphatase and tensin homolog	Homo sapiens	140-144
27606614-14	2016	In addition, pretreatment with the PI3K-Akt-selective inhibitor LY294002 and shRNA targeted to Akt reduced periodic mechanical stress-induced chondrocyte proliferation and phosphorylation of ERK1/2, while the phosphorylation levels of EGFR and PKCdelta were not inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Rattus norvegicus	40-43
26254549-10	2016	TGF-beta1 increased microglial p38 MAPK and Akt phosphorylation, both of which were blocked by the p38 inhibitor SB203580 and the PI3K inhibitor LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	transforming growth factor beta 1	Homo sapiens	0-9
26254549-10	2016	TGF-beta1 increased microglial p38 MAPK and Akt phosphorylation, both of which were blocked by the p38 inhibitor SB203580 and the PI3K inhibitor LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	mitogen-activated protein kinase 14	Homo sapiens	31-34
26254549-10	2016	TGF-beta1 increased microglial p38 MAPK and Akt phosphorylation, both of which were blocked by the p38 inhibitor SB203580 and the PI3K inhibitor LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	mitogen-activated protein kinase 14	Homo sapiens	99-102
26254549-11	2016	Pretreatment of microglia with either SB203580 or LY294002 impaired the ability of TGF-beta1 to inhibit MPP(+)-induced DAergic neuronal loss and microglial activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	transforming growth factor beta 1	Homo sapiens	83-92
27230035-12	2016	LY294002 restored the pro-proliferation effect of miR-221 on Capan-2 cells, while SC-79 had no additional effect on cell proliferation in Capan-2 cells transfected with miR-221 mimics.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	microRNA 221	Homo sapiens	50-57
27372651-15	2016	The protective effects of geniposide were partially reversed by glucagon-like pepitide-1 receptor antagonist exendin-(9-39) and the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	132-161
27744432-8	2016	LY294002, a specific PI3K inhibitor, partially reversed the decreased HMGB1 expression, increased p-Akt expression induced by hesperidin and abolished the anti-apoptotic, anti-inflammatory and anti-oxidative effects of hesperidin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	high mobility group box 1	Rattus norvegicus	70-75
27606614-14	2016	In addition, pretreatment with the PI3K-Akt-selective inhibitor LY294002 and shRNA targeted to Akt reduced periodic mechanical stress-induced chondrocyte proliferation and phosphorylation of ERK1/2, while the phosphorylation levels of EGFR and PKCdelta were not inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	mitogen activated protein kinase 3	Rattus norvegicus	191-197
27744432-8	2016	LY294002, a specific PI3K inhibitor, partially reversed the decreased HMGB1 expression, increased p-Akt expression induced by hesperidin and abolished the anti-apoptotic, anti-inflammatory and anti-oxidative effects of hesperidin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	100-103
27802437-5	2016	However, the MAPK inhibitor PD98059 and/or PI3K inhibitor LY294002 were able to antagonize the effects of VPA by abolishing ERK/Akt activations and cancelling GSK3beta suppression, thus it impaired VPA apoptosis-inducing effects on glioma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	mitogen-activated protein kinase 1	Homo sapiens	124-127
27606614-14	2016	In addition, pretreatment with the PI3K-Akt-selective inhibitor LY294002 and shRNA targeted to Akt reduced periodic mechanical stress-induced chondrocyte proliferation and phosphorylation of ERK1/2, while the phosphorylation levels of EGFR and PKCdelta were not inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	epidermal growth factor receptor	Rattus norvegicus	235-239
27802437-5	2016	However, the MAPK inhibitor PD98059 and/or PI3K inhibitor LY294002 were able to antagonize the effects of VPA by abolishing ERK/Akt activations and cancelling GSK3beta suppression, thus it impaired VPA apoptosis-inducing effects on glioma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Homo sapiens	128-131
27328502-5	2016	Protein expressions of Bad, Bax, and Foxo3a in GCs in APJ-siRNA group, LY294002 group, and HIMO group were apparently upregulated (p &lt; 0.05), and the protein expression of Bcl-2 in APJ-siRNA group, LY294002 group, and HIMO group was obviously downregulated (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	apelin receptor	Rattus norvegicus	54-57
27802437-5	2016	However, the MAPK inhibitor PD98059 and/or PI3K inhibitor LY294002 were able to antagonize the effects of VPA by abolishing ERK/Akt activations and cancelling GSK3beta suppression, thus it impaired VPA apoptosis-inducing effects on glioma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	glycogen synthase kinase 3 beta	Homo sapiens	159-167
27328502-5	2016	Protein expressions of Bad, Bax, and Foxo3a in GCs in APJ-siRNA group, LY294002 group, and HIMO group were apparently upregulated (p &lt; 0.05), and the protein expression of Bcl-2 in APJ-siRNA group, LY294002 group, and HIMO group was obviously downregulated (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	BCL2, apoptosis regulator	Rattus norvegicus	175-180
26652865-9	2016	The effects of IGF-1 could be blocked by preincubation with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	insulin like growth factor 1	Homo sapiens	15-20
26873077-6	2016	Ly294002 (the inhibitor of PI3K) was used to determine the mechanism of SAA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	serum amyloid A cluster	Mus musculus	72-75
26873077-10	2016	It markedly reduced the level of p-NF-kappaB, as also p-Akt, which was partly blocked by Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	35-44
26873077-10	2016	It markedly reduced the level of p-NF-kappaB, as also p-Akt, which was partly blocked by Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	thymoma viral proto-oncogene 1	Mus musculus	56-59
26949405-7	2016	BNC increased phosphorylation of Akt following OGD/R, while LY294002 attenuated BNC induced increase of phosphorylated Akt expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	119-122
27140596-0	2016	Phosphoinositide 3-kinase inhibitor LY294002 ameliorates the severity of myosin-induced myocarditis in mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	0-25
27140596-6	2016	RESULTS: LY294002 significantly alleviated EAM injury in mice, as indicated by the reduction of cardiac necrosis, inflammatory infiltrates, and CD3(+) T cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	CD3 antigen, epsilon polypeptide	Mus musculus	144-147
27140596-8	2016	In the present study, LY294002 resulted in a moderate reduction in absolute CD4(+) cell numbers and a significant decrease in the absolute numbers of CD8(+) cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	CD4 antigen	Mus musculus	76-79
27140596-9	2016	Consequently, LY294002 increased the CD4(+)/CD8(+) ratio compared with peptide treatment alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	CD4 antigen	Mus musculus	37-40
27671480-6	2016	In addition, Rh2-O down-regulated the phosphorylation of Akt, and its inhibitor LY294002 promoted Rh2-O-induced G1 phase arrest.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	Rh associated glycoprotein	Homo sapiens	13-16
26930476-7	2016	These losartan-mediated protective effects were inhibited by the phosphatidyl-inositol-3-kinase (PI3K) inhibitor LY294002, indicating that losartan provides significant protection from cocaine-induced renal toxicity through PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	thymoma viral proto-oncogene 1	Mus musculus	229-232
26646104-7	2016	Additionally, HMGA2 knockdown or inhibition of the PI3K-AKT signalling pathway with LY294002 mimicked the effects of miR-23b overexpression on HG-mediated EMT, whereas HMGA2 overexpression or activation of the PI3K-AKT signalling pathway with BpV prevented the effects of miR-23b on HG-mediated EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	microRNA 23b	Mus musculus	117-124
27990160-10	2016	LY294002 (10 muM), U0126 (10 muM), AZD8055 (1 muM), and sunitinib (1 muM) inhibited PPGL cell proliferation in ten primary cultures of tissues, including four from patients with gene mutations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	latexin	Homo sapiens	13-16
26467565-7	2016	And this effect was blocked by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	35-60
27671480-6	2016	In addition, Rh2-O down-regulated the phosphorylation of Akt, and its inhibitor LY294002 promoted Rh2-O-induced G1 phase arrest.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	57-60
27671480-6	2016	In addition, Rh2-O down-regulated the phosphorylation of Akt, and its inhibitor LY294002 promoted Rh2-O-induced G1 phase arrest.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	Rh associated glycoprotein	Homo sapiens	98-101
26414235-5	2016	To investigate the mechanism, LY294002 was introduced, the phosphatidylinositol-3-kinase (PI3K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	59-88
26346601-7	2016	In pAPPswe transfected SH-SY5Y cells, Ngb not only decreased the generation of Abeta42, but also attenuated mitochondrial dysfunction and apoptosis through suppressing the activation of caspase-3, caspase-9 by Akt activating phosphorylation, which were restrained by phosphatidylinositol 3-kinase inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	308-316	neuroglobin	Homo sapiens	38-41
26554875-11	2016	LY294002 activation reduced the IGF2-induced effects (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 2	Homo sapiens	32-36
26414235-7	2016	The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Rattus norvegicus	171-174
26414235-7	2016	The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	BCL2 associated X, apoptosis regulator	Rattus norvegicus	138-141
26414235-7	2016	The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Rattus norvegicus	302-305
26524639-8	2016	In addition, GPR39-induced proliferation and differentiation of porcine intramuscular preadipocytes was partially blocked by the Akt inhibitor (PDTC) and the PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	G protein-coupled receptor 39	Homo sapiens	13-18
26584949-5	2016	PAN reduces Akt phosphorylation levels of GSK3beta, LY294002 can promote podocyte apoptosis induced by PAN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	12-15
26584949-5	2016	PAN reduces Akt phosphorylation levels of GSK3beta, LY294002 can promote podocyte apoptosis induced by PAN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	glycogen synthase kinase 3 beta	Homo sapiens	42-50
26414235-7	2016	The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	BCL2, apoptosis regulator	Rattus norvegicus	142-147
26548367-7	2016	In addition, the effects of albumin were partially blocked by Ly294002, a specific inhibitor of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
25577170-8	2016	This neuroprotective effect of atorvastatin was blocked by LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor and by FR180204, a selective extracellular signal-related kinase (ERK) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	71-100
26870244-11	2016	Phosphoinositide 3-kinase (PI3K)/Akt activation was observed in PC9/G cells in the presence of gefitinib and the sensitivity of PC9/G cells to gefitinib was also able to be restored by PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	AKT serine/threonine kinase 1	Homo sapiens	33-36
26647861-8	2016	In LPS-induced hepatitis, treatment with LY294002 clearly inhibited intrahepatic synthesis of various disease-relevant proinflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta and interferon-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	tumor necrosis factor	Mus musculus	156-183
26647861-8	2016	In LPS-induced hepatitis, treatment with LY294002 clearly inhibited intrahepatic synthesis of various disease-relevant proinflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta and interferon-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	interleukin 1 beta	Mus musculus	205-213
26647861-8	2016	In LPS-induced hepatitis, treatment with LY294002 clearly inhibited intrahepatic synthesis of various disease-relevant proinflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta and interferon-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	interferon gamma	Mus musculus	218-234
26648531-12	2016	Furthermore, treatment with the Akt inhibitor LY294002 reduced the effectiveness of AST on DACD in rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Rattus norvegicus	32-35
26639237-7	2016	LY294002 and gemcitabine hydrochloride combined with IR better inhibited cell migration, VM formation and MMP-2 mRNA expression of Panc-1 cells in vitro, and we also proved that the novel therapeutic regimen better inhibited tumor growth, tumor metastasis and VM formation of orthotopic Panc-1 xenografts by suppressing the PI3K/MMPs/Ln-5gamma2 signaling pathway in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	matrix metallopeptidase 2	Homo sapiens	106-111
26639237-7	2016	LY294002 and gemcitabine hydrochloride combined with IR better inhibited cell migration, VM formation and MMP-2 mRNA expression of Panc-1 cells in vitro, and we also proved that the novel therapeutic regimen better inhibited tumor growth, tumor metastasis and VM formation of orthotopic Panc-1 xenografts by suppressing the PI3K/MMPs/Ln-5gamma2 signaling pathway in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	matrix metallopeptidase 2	Homo sapiens	329-333
26802652-7	2016	Additionally, PI3K-specific inhibitor Ly294002 suppressed the expression of pPI3K (Tyr458), pAkt (Ser473), CCND1, and CDK4 in PC9-shPDCD4 and A549-shPDCD4 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	cyclin D1	Homo sapiens	107-112
26802652-7	2016	Additionally, PI3K-specific inhibitor Ly294002 suppressed the expression of pPI3K (Tyr458), pAkt (Ser473), CCND1, and CDK4 in PC9-shPDCD4 and A549-shPDCD4 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	cyclin dependent kinase 4	Homo sapiens	118-122
26870244-11	2016	Phosphoinositide 3-kinase (PI3K)/Akt activation was observed in PC9/G cells in the presence of gefitinib and the sensitivity of PC9/G cells to gefitinib was also able to be restored by PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	proprotein convertase subtilisin/kexin type 9	Homo sapiens	64-67
26802652-7	2016	Additionally, PI3K-specific inhibitor Ly294002 suppressed the expression of pPI3K (Tyr458), pAkt (Ser473), CCND1, and CDK4 in PC9-shPDCD4 and A549-shPDCD4 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	proprotein convertase subtilisin/kexin type 9	Homo sapiens	126-129
27098148-6	2016	Pretreatment with a nuclear factor-kappaB (NF-kappaB) inhibitor (PDTC) or PI3K/AKT inhibitor (LY294002) was proven to abolish the promoting effect of IL-17A on the invasion ability of colorectal cancer cells and upregulation of MMP-2/9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	AKT serine/threonine kinase 1	Homo sapiens	79-82
26870244-11	2016	Phosphoinositide 3-kinase (PI3K)/Akt activation was observed in PC9/G cells in the presence of gefitinib and the sensitivity of PC9/G cells to gefitinib was also able to be restored by PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	proprotein convertase subtilisin/kexin type 9	Homo sapiens	128-131
27098148-6	2016	Pretreatment with a nuclear factor-kappaB (NF-kappaB) inhibitor (PDTC) or PI3K/AKT inhibitor (LY294002) was proven to abolish the promoting effect of IL-17A on the invasion ability of colorectal cancer cells and upregulation of MMP-2/9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	interleukin 17A	Homo sapiens	150-156
27057280-7	2016	The inhibitor of PI3K/Akt, LY294002 significantly abolished CCL21 induced chemoresistance and mammosphere formation of HCT116 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	C-C motif chemokine ligand 21	Homo sapiens	60-65
27098148-6	2016	Pretreatment with a nuclear factor-kappaB (NF-kappaB) inhibitor (PDTC) or PI3K/AKT inhibitor (LY294002) was proven to abolish the promoting effect of IL-17A on the invasion ability of colorectal cancer cells and upregulation of MMP-2/9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	matrix metallopeptidase 2	Homo sapiens	228-235
26515369-9	2015	In contrast, inhibition of AKT signaling with LY294002 suppressed the ability of FSH and IGF-I to regulate CTNNB1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Bos taurus	27-30
27143997-8	2016	The interaction between Shh and PI3K/Akt pathways was clarified by specific PI3K inhibitor LY294002 or Shh inhibitor GDC-0449.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	sonic hedgehog	Mus musculus	24-27
27143997-8	2016	The interaction between Shh and PI3K/Akt pathways was clarified by specific PI3K inhibitor LY294002 or Shh inhibitor GDC-0449.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	thymoma viral proto-oncogene 1	Mus musculus	37-40
27143997-9	2016	Moreover, LY294002 and GDC-0449 pretreatment both induced phosphorylated GSK-3beta downregulation and significantly promoted apoptosis induced by TMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	glycogen synthase kinase 3 beta	Mus musculus	73-82
26234766-10	2016	Both Snail and MT1-MMP expressions in fibroblasts and cellular invasive activities in 3D collagen induced by PDGF-D were inhibited by LY294002, SP600125, and U1026, the inhibitors of PI3K, JNK, and ERK1/2 signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	snail family transcriptional repressor 1	Homo sapiens	5-10
26234766-10	2016	Both Snail and MT1-MMP expressions in fibroblasts and cellular invasive activities in 3D collagen induced by PDGF-D were inhibited by LY294002, SP600125, and U1026, the inhibitors of PI3K, JNK, and ERK1/2 signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	matrix metallopeptidase 14	Homo sapiens	15-22
26234766-10	2016	Both Snail and MT1-MMP expressions in fibroblasts and cellular invasive activities in 3D collagen induced by PDGF-D were inhibited by LY294002, SP600125, and U1026, the inhibitors of PI3K, JNK, and ERK1/2 signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	platelet derived growth factor D	Homo sapiens	109-115
26234766-10	2016	Both Snail and MT1-MMP expressions in fibroblasts and cellular invasive activities in 3D collagen induced by PDGF-D were inhibited by LY294002, SP600125, and U1026, the inhibitors of PI3K, JNK, and ERK1/2 signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	mitogen-activated protein kinase 8	Homo sapiens	189-192
26234766-10	2016	Both Snail and MT1-MMP expressions in fibroblasts and cellular invasive activities in 3D collagen induced by PDGF-D were inhibited by LY294002, SP600125, and U1026, the inhibitors of PI3K, JNK, and ERK1/2 signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	mitogen-activated protein kinase 3	Homo sapiens	198-204
26717921-9	2015	Treatment of phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002, deleted Adv-CAT-induced p-Akt/p-eNOS/NO protective signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	catalase	Rattus norvegicus	92-95
26717921-9	2015	Treatment of phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002, deleted Adv-CAT-induced p-Akt/p-eNOS/NO protective signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Rattus norvegicus	106-109
26679484-12	2015	LY294002(PI3K inhibitor) attenuated estrogen-enhanced, AQP5 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	aquaporin 5	Mus musculus	55-59
26885260-7	2015	When rats were treated with PI3K inhibitor LY294002 5 min before reperfusion (0.3 mg/kg), p-Akt expression at R 3 h and iNOS expression at R 24 h were significantly inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Rattus norvegicus	92-95
26885260-7	2015	When rats were treated with PI3K inhibitor LY294002 5 min before reperfusion (0.3 mg/kg), p-Akt expression at R 3 h and iNOS expression at R 24 h were significantly inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	nitric oxide synthase 2	Rattus norvegicus	120-124
26528797-13	2015	LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, reversed the protective effect of levosimendan on IL-1beta-induced apoptosis in TUNEL assay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 beta	Rattus norvegicus	110-118
26528797-14	2015	In addition, levosimendan and 1400W inhibited the IL-1beta-induced cytosolic translocation of cytochrome-c. LY294002 reversed the suppressive effects of levosimendan.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	interleukin 1 beta	Rattus norvegicus	50-58
26566676-3	2015	This downregulation of Mfn2 was blocked by different inhibitors (mTOR inhibitor rapamycin, PI3K inhibitor LY294002, and Akt inhibitor A443654), producing cells that were arrested in the G0/G1 stage of the cell cycle.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	mitofusin 2	Homo sapiens	23-27
26597376-9	2015	However, after an intracerebroventricular injection of LY294002 (an inhibitor of Akt1), the above neuroprotective effects of atorvastatin are attenuated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Rattus norvegicus	81-85
26642930-7	2015	Furthermore, it was established that the neuroprotective activity of GK-2 was completely abolished by a selective inhibitor of phosphatidylinositol 3-kinase (LY294002) but not by a specific inhibitor of mitogen-activated protein kinases MEK1 and MEK2 (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	glycerol kinase 2	Rattus norvegicus	69-73
27313828-7	2016	SPRC-induced HO-1 expression and Nrf2 translocation were abolished by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	heme oxygenase 1	Homo sapiens	13-17
27313828-7	2016	SPRC-induced HO-1 expression and Nrf2 translocation were abolished by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
27795807-5	2016	Moreover, the application of LY294002 (Akt-specific inhibitor) or 1400W (iNOS-selective inhibitor) cancelled the cellular protective effects of NS398.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Rattus norvegicus	39-42
26505797-8	2015	AKT inhibitors (LY294002 and perifosine) blocked escin-induced AKT activation, and dramatically inhibited Nrf2 phosphorylation, its cytosol accumulation and nuclear translocation in RPE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	0-3
26505797-8	2015	AKT inhibitors (LY294002 and perifosine) blocked escin-induced AKT activation, and dramatically inhibited Nrf2 phosphorylation, its cytosol accumulation and nuclear translocation in RPE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	63-66
26505797-8	2015	AKT inhibitors (LY294002 and perifosine) blocked escin-induced AKT activation, and dramatically inhibited Nrf2 phosphorylation, its cytosol accumulation and nuclear translocation in RPE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	NFE2 like bZIP transcription factor 2	Homo sapiens	106-110
26470810-10	2015	The PI3-kinase inhibitor LY294002, known to inhibit TRPC translocation, decreased the response to TRH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	thyrotropin releasing hormone	Rattus norvegicus	98-101
26607438-8	2015	PI3K inhibitor LY294002, Akt inhibitor 1701-1, ERK1/2 inhibitor PD98059 attenuated the increase of the cell diameter, volume, protein content induced by apelin-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	apelin	Rattus norvegicus	153-159
26515369-9	2015	In contrast, inhibition of AKT signaling with LY294002 suppressed the ability of FSH and IGF-I to regulate CTNNB1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	insulin like growth factor 1	Bos taurus	89-94
26515369-9	2015	In contrast, inhibition of AKT signaling with LY294002 suppressed the ability of FSH and IGF-I to regulate CTNNB1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	catenin beta 1	Bos taurus	107-113
26515369-10	2015	Additionally, LY294002 treatment reduced FSH and IGF-I mediated E2 medium concentrations (P &lt;= 0.004).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	insulin like growth factor 1	Bos taurus	49-54
26653561-11	2015	PS473 Akt and pT308 Akt expression level was increased significantly as well, which were almost the same with those transfected with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	AKT serine/threonine kinase 1	Homo sapiens	6-9
26520898-9	2015	The in vitro experiments revealed that irisin inhibited high glucose-induced apoptosis, oxidative stress and increased antioxidant enzymes expression in HUVECs, and pretreatment with LY294002, l-NAME, AMPK-siRNA or eNOS-siRNA, attenuated the protection of irisin on HUVECs apoptosis induced by high glucose.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	fibronectin type III domain containing 5	Homo sapiens	39-45
26653561-11	2015	PS473 Akt and pT308 Akt expression level was increased significantly as well, which were almost the same with those transfected with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	AKT serine/threonine kinase 1	Homo sapiens	20-23
26494002-5	2015	Apelin increased the phosphorylation of Akt, whereas LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), and an Akt1/2 kinase inhibitor blocked the apelin-induced VSMC migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	apelin	Homo sapiens	160-166
26456500-9	2015	LY294002 (an inhibitor of GSK3beta phosphorylation) and LiCl (an inhibitor of GSK3beta activity) diminished and potentiated increase of IL-10 levels by DGA, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Mus musculus	26-34
26456500-9	2015	LY294002 (an inhibitor of GSK3beta phosphorylation) and LiCl (an inhibitor of GSK3beta activity) diminished and potentiated increase of IL-10 levels by DGA, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 10	Mus musculus	136-141
26453509-6	2015	Interestingly, PI3K inhibitor LY294002 completely blocked the TNF-alpha-induced activation of p85, Akt and the whole cascade of the NF-kappaB signaling components and suppressed inflammatory cytokines production in mRNA and protein levels similarly as CuE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	tumor necrosis factor	Homo sapiens	62-71
26453509-6	2015	Interestingly, PI3K inhibitor LY294002 completely blocked the TNF-alpha-induced activation of p85, Akt and the whole cascade of the NF-kappaB signaling components and suppressed inflammatory cytokines production in mRNA and protein levels similarly as CuE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	94-97
26453509-6	2015	Interestingly, PI3K inhibitor LY294002 completely blocked the TNF-alpha-induced activation of p85, Akt and the whole cascade of the NF-kappaB signaling components and suppressed inflammatory cytokines production in mRNA and protein levels similarly as CuE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	99-102
26453509-6	2015	Interestingly, PI3K inhibitor LY294002 completely blocked the TNF-alpha-induced activation of p85, Akt and the whole cascade of the NF-kappaB signaling components and suppressed inflammatory cytokines production in mRNA and protein levels similarly as CuE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	nuclear factor kappa B subunit 1	Homo sapiens	132-141
26497980-7	2015	Furthermore, proliferation of SAS aggregates is also inhibited by LY294002 and MK2206, which are inhibitors of PI3K and AKT, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	120-123
25900259-12	2015	LY294002 inhibited only Akt phosphorylation, and FAK phosphorylation was not influenced under periostin stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	24-27
26884863-8	2015	The levels of p-S6K1 were significantly decreased by incubation with LY294002, but the effect could be reversed by E2 in combination with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	ribosomal protein S6 kinase B1	Homo sapiens	16-20
26884863-8	2015	The levels of p-S6K1 were significantly decreased by incubation with LY294002, but the effect could be reversed by E2 in combination with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	ribosomal protein S6 kinase B1	Homo sapiens	16-20
26459773-5	2015	The cells exposed to hypoxia were also treated with the PI3K/AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	thymoma viral proto-oncogene 1	Mus musculus	61-64
26459773-11	2015	Treatment with LY294002 decreased the mRNA and protein expression levels of CCN1 in the cells exposed to hypoxia (both P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cellular communication network factor 1	Mus musculus	76-80
26012840-7	2015	Finally, we demonstrated that an inhibitor of PI3-K/Akt (LY294002) but not MAPK/ERK1/2 (U0126) pathway blocked the protection mediated by UDA in all tested models of SH-SY5Y cell injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	52-55
26458524-11	2015	However, treatment of LmiR-130a-transfected mice with LY294002, a PI3K inhibitor, completely abolished miR-130a-induced attenuation of cardiac dysfunction after MI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	microRNA 130a	Mus musculus	23-31
26769840-11	2015	In addition, ERA promoted phosphorylation of Akt and eNOS, which was prevented by wortmannin and LY294002, indicating that ERA induces eNOS phosphorylation through the PI3-kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Rattus norvegicus	45-48
26769840-11	2015	In addition, ERA promoted phosphorylation of Akt and eNOS, which was prevented by wortmannin and LY294002, indicating that ERA induces eNOS phosphorylation through the PI3-kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
26494002-6	2015	Apelin dose-dependently induced phosphorylation of Forkhead box O3a (FoxO3a) and promoted its translocation from the nucleus to cytoplasm, which were blocked by LY294002 and Akt1/2 kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	apelin	Homo sapiens	0-6
25307508-6	2015	Suppressed plasma membrane GLUT1 localization in ovarian cancer was found to be associated with the inhibition of Akt activity by RSV, as confirmed by the action of the Akt inhibitors (LY294002 and Akt inhibitor IV), as well as overexpression of a constitutive active form of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	solute carrier family 2 member 1	Homo sapiens	27-32
26494002-6	2015	Apelin dose-dependently induced phosphorylation of Forkhead box O3a (FoxO3a) and promoted its translocation from the nucleus to cytoplasm, which were blocked by LY294002 and Akt1/2 kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	forkhead box O3	Homo sapiens	69-75
26440581-5	2015	The PI3K/Akt inhibitor LY294002 prevented totarol neuroprotective effect by suppressing the totarol-induced changes in HO-1 expression and the activities of GSH and SOD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Rattus norvegicus	9-12
26350566-5	2015	Furthermore, we demonstrated that inhibition of Akt phosphorylation (LY294002) abrogated the Lcn2-promoted proliferation in cultured human pulmonary artery smooth muscle cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	48-51
26350566-5	2015	Furthermore, we demonstrated that inhibition of Akt phosphorylation (LY294002) abrogated the Lcn2-promoted proliferation in cultured human pulmonary artery smooth muscle cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	lipocalin 2	Homo sapiens	93-97
26503358-11	2015	Overexpression of Cav-1 upregulated the IC50 value, but under the effect of Notch-1 siRNA or LY294002 or PDTC, the IC50 value was markedly decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	caveolin 1	Homo sapiens	18-23
26165503-12	2015	MK-2206 and LY294002, the PI3K/Akt inhibitors, repressed Dex-induced up-regulation of FOXO3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Homo sapiens	31-34
26165503-12	2015	MK-2206 and LY294002, the PI3K/Akt inhibitors, repressed Dex-induced up-regulation of FOXO3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	forkhead box O3	Homo sapiens	86-91
26573128-10	2015	The expression of NF45 was reduced by LY294002 (a PI3K/Akt inhibitor), but not SB203580 (a p38 inhibitor), suggesting that NF45 prevented H/R-induced H9c2 cell apoptosis via PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	interleukin enhancer binding factor 2	Homo sapiens	18-22
26573128-10	2015	The expression of NF45 was reduced by LY294002 (a PI3K/Akt inhibitor), but not SB203580 (a p38 inhibitor), suggesting that NF45 prevented H/R-induced H9c2 cell apoptosis via PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	interleukin enhancer binding factor 2	Homo sapiens	123-127
26440581-5	2015	The PI3K/Akt inhibitor LY294002 prevented totarol neuroprotective effect by suppressing the totarol-induced changes in HO-1 expression and the activities of GSH and SOD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	heme oxygenase 1	Rattus norvegicus	119-123
26485504-8	2015	LY294002 (phosphatidylinositol-3 kinase (PI3K) inhibitor) and PD98059 (extracellular signal regulates kinase-1/2 (ERK1/2) inhibitor) obviously reduced baicalin-induced MRTF-A expression and transactivity and expression of MCL-1 and BCL-2, which further abolished the anti-apoptotic effect of baicalin on neuronal apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	myocardin related transcription factor A	Rattus norvegicus	168-174
26884933-6	2015	Activated PI3K/Akt signaling pathway could play a protection role in the cardiomyocytes H/R injury process which could be inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Rattus norvegicus	15-18
26441085-6	2015	Additionally, Reelin treatment led to increased phosphorylation of AKT, GSK3beta, and JNK, which were all effectively blocked by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	reelin	Mus musculus	14-20
26441085-6	2015	Additionally, Reelin treatment led to increased phosphorylation of AKT, GSK3beta, and JNK, which were all effectively blocked by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	thymoma viral proto-oncogene 1	Mus musculus	67-70
26441085-6	2015	Additionally, Reelin treatment led to increased phosphorylation of AKT, GSK3beta, and JNK, which were all effectively blocked by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	glycogen synthase kinase 3 beta	Mus musculus	72-80
26441085-6	2015	Additionally, Reelin treatment led to increased phosphorylation of AKT, GSK3beta, and JNK, which were all effectively blocked by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	mitogen-activated protein kinase 8	Mus musculus	86-89
26485504-8	2015	LY294002 (phosphatidylinositol-3 kinase (PI3K) inhibitor) and PD98059 (extracellular signal regulates kinase-1/2 (ERK1/2) inhibitor) obviously reduced baicalin-induced MRTF-A expression and transactivity and expression of MCL-1 and BCL-2, which further abolished the anti-apoptotic effect of baicalin on neuronal apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	MCL1 apoptosis regulator, BCL2 family member	Rattus norvegicus	222-227
26485504-8	2015	LY294002 (phosphatidylinositol-3 kinase (PI3K) inhibitor) and PD98059 (extracellular signal regulates kinase-1/2 (ERK1/2) inhibitor) obviously reduced baicalin-induced MRTF-A expression and transactivity and expression of MCL-1 and BCL-2, which further abolished the anti-apoptotic effect of baicalin on neuronal apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2, apoptosis regulator	Rattus norvegicus	232-237
26528819-5	2015	IL-23 production was dose-dependently inhibited by the PI3K inhibitors LY294002 and wortmannin, whereas IL-12 production increased dose-dependently.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	interleukin 23 subunit alpha	Homo sapiens	0-5
26635480-16	2015	The enhanced invasion of thyroid cancer cells by Thiamet-G treatment or OGT overexpression was significantly depressed by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	72-75
26523832-6	2015	bFGF induced Akt phosphorylation, but it was attenuated by the FGFR inhibitor SU5402 and the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	fibroblast growth factor 2	Canis lupus familiaris	0-4
26226221-11	2015	However, KLF14"s ability to increase glucose uptake and Akt activation was significantly attenuated by LY294002, a PI3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	Kruppel-like factor 14	Mus musculus	9-14
26363213-7	2015	Further, 10(-8) M BPA significantly increased the phosphorylation of ERK1/2, p38-MAPK, and Akt in SkBr3 cells, while only PI3K/Akt inhibitor LY294002 attenuated the BPA induced down regulation of FOXA1 and E-Cadherin (E-Cad).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Homo sapiens	127-130
26162710-3	2015	Moreover, treatment with LY294002, a specific inhibitor of PI3k/Akt signaling, significantly reduced Caspase-1 cleavage, NALP1 inflammasome activation and attenuated morphine tolerance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Rattus norvegicus	64-67
26162710-3	2015	Moreover, treatment with LY294002, a specific inhibitor of PI3k/Akt signaling, significantly reduced Caspase-1 cleavage, NALP1 inflammasome activation and attenuated morphine tolerance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	caspase 1	Rattus norvegicus	101-110
26162710-3	2015	Moreover, treatment with LY294002, a specific inhibitor of PI3k/Akt signaling, significantly reduced Caspase-1 cleavage, NALP1 inflammasome activation and attenuated morphine tolerance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	NLR family, pyrin domain containing 1A	Rattus norvegicus	121-126
25986891-10	2015	miRNA-150 knockdown activated PI3K-Akt pathway and LY294002 reversed the effect of miR-150 knockdown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	microRNA 150	Homo sapiens	83-90
26226221-11	2015	However, KLF14"s ability to increase glucose uptake and Akt activation was significantly attenuated by LY294002, a PI3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	thymoma viral proto-oncogene 1	Mus musculus	56-59
26397153-8	2015	Moreover, C/EBPalpha expression was reduced by PI3K inhibitor LY294002 and mTOR inhibitor RAD001 in NB4 cells, suggesting that inactivation of the PI3K/Akt/mTOR pathway was responsible for C/EBPalpha suppression in APL cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	CCAAT enhancer binding protein alpha	Homo sapiens	10-20
26397153-8	2015	Moreover, C/EBPalpha expression was reduced by PI3K inhibitor LY294002 and mTOR inhibitor RAD001 in NB4 cells, suggesting that inactivation of the PI3K/Akt/mTOR pathway was responsible for C/EBPalpha suppression in APL cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	AKT serine/threonine kinase 1	Homo sapiens	152-155
26302186-10	2015	Finally, both AKT and ERK inhibitors (LY294002 and UO126) blocked effects of LPS on the depression of ENaC-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	14-17
26266487-8	2015	The PI3 kinase inhibitor, LY294002, decreased pAkt and abolished the protective effect of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	peptidase inhibitor 3	Homo sapiens	4-7
26266487-8	2015	The PI3 kinase inhibitor, LY294002, decreased pAkt and abolished the protective effect of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	insulin	Homo sapiens	90-97
26241029-7	2015	The E2-BSA induced-COX-2 and prostaglandin release were subjected to regulation by both EGFR and PI3K signaling as inhibitors of c-Src kinase (PP2), EGFR (EGFR inhibitor) and PI-3 kinase (LY294002) attenuated E2-BSA mediated effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	19-24
26241029-7	2015	The E2-BSA induced-COX-2 and prostaglandin release were subjected to regulation by both EGFR and PI3K signaling as inhibitors of c-Src kinase (PP2), EGFR (EGFR inhibitor) and PI-3 kinase (LY294002) attenuated E2-BSA mediated effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	epidermal growth factor receptor	Rattus norvegicus	88-92
26241029-7	2015	The E2-BSA induced-COX-2 and prostaglandin release were subjected to regulation by both EGFR and PI3K signaling as inhibitors of c-Src kinase (PP2), EGFR (EGFR inhibitor) and PI-3 kinase (LY294002) attenuated E2-BSA mediated effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	C-terminal Src kinase	Rattus norvegicus	129-141
26241029-7	2015	The E2-BSA induced-COX-2 and prostaglandin release were subjected to regulation by both EGFR and PI3K signaling as inhibitors of c-Src kinase (PP2), EGFR (EGFR inhibitor) and PI-3 kinase (LY294002) attenuated E2-BSA mediated effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	epidermal growth factor receptor	Rattus norvegicus	149-153
26241029-7	2015	The E2-BSA induced-COX-2 and prostaglandin release were subjected to regulation by both EGFR and PI3K signaling as inhibitors of c-Src kinase (PP2), EGFR (EGFR inhibitor) and PI-3 kinase (LY294002) attenuated E2-BSA mediated effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	epidermal growth factor receptor	Rattus norvegicus	149-153
26302186-10	2015	Finally, both AKT and ERK inhibitors (LY294002 and UO126) blocked effects of LPS on the depression of ENaC-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	mitogen-activated protein kinase 1	Homo sapiens	22-25
26302186-10	2015	Finally, both AKT and ERK inhibitors (LY294002 and UO126) blocked effects of LPS on the depression of ENaC-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	sodium channel epithelial 1 subunit gamma	Homo sapiens	102-112
26557022-4	2015	Both Akt phosphorylation and CCL11 expression induced by thrombin were attenuated in the presence of pertussis toxin (PTX), an inhibitor of Gi protein-coupled receptor, or LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	AKT serine/threonine kinase 1	Homo sapiens	5-8
26364578-8	2015	The elevation of PI3 kinase (PI3K) and p-Akt/Akt activities induced by ZnO NP was significantly decreased by esculetin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Homo sapiens	41-44
26557022-4	2015	Both Akt phosphorylation and CCL11 expression induced by thrombin were attenuated in the presence of pertussis toxin (PTX), an inhibitor of Gi protein-coupled receptor, or LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	C-C motif chemokine ligand 11	Homo sapiens	29-34
26557022-4	2015	Both Akt phosphorylation and CCL11 expression induced by thrombin were attenuated in the presence of pertussis toxin (PTX), an inhibitor of Gi protein-coupled receptor, or LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	coagulation factor II, thrombin	Homo sapiens	57-65
26299938-7	2015	Further experiments showed that LY294002, an inhibitor of phosphoinositide-3 kinase (PI3K), decreased rhSHH-induced upregulation of MMP-2 and -9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	matrix metallopeptidase 2	Homo sapiens	132-144
26364578-8	2015	The elevation of PI3 kinase (PI3K) and p-Akt/Akt activities induced by ZnO NP was significantly decreased by esculetin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Homo sapiens	45-48
26492242-10	2015	Pretreatment with PI3K/AKT inhibitor LY294002 strikingly ameliorated the inhibitory effects of miR-223 on the activation of TLR4 and p65, concomitant with the increase in lipid deposition and inflammatory cytokine production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	microRNA 223	Mus musculus	95-102
26324335-8	2015	Moreover, MHY-449 downregulated the phosphorylation of Akt, and the phosphatidylinositol-3 kinase/Akt inhibitor LY294002 was found to enhance its induction of apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Homo sapiens	98-101
26492242-10	2015	Pretreatment with PI3K/AKT inhibitor LY294002 strikingly ameliorated the inhibitory effects of miR-223 on the activation of TLR4 and p65, concomitant with the increase in lipid deposition and inflammatory cytokine production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	thymoma viral proto-oncogene 1	Mus musculus	23-26
26522351-8	2015	The expressions of p-ACL and p-NF-kappaB protein in MCF-7 cells treated with 10 mumol/L LY294002 were also reduced significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	nuclear factor kappa B subunit 1	Homo sapiens	31-40
26492242-10	2015	Pretreatment with PI3K/AKT inhibitor LY294002 strikingly ameliorated the inhibitory effects of miR-223 on the activation of TLR4 and p65, concomitant with the increase in lipid deposition and inflammatory cytokine production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	toll-like receptor 4	Mus musculus	124-128
26492242-10	2015	Pretreatment with PI3K/AKT inhibitor LY294002 strikingly ameliorated the inhibitory effects of miR-223 on the activation of TLR4 and p65, concomitant with the increase in lipid deposition and inflammatory cytokine production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	133-136
26311737-9	2015	Furthermore, the inhibition of PI3K/Akt by LY294002/si-Akt or of mTOR by rapamycin augmented LicA-induced apoptosis and autophagy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	36-39
26279331-8	2015	Consistent with these results, nicorandil-mediated neuroprotection was reduced in the Akt1+/- mutant mice and inhibited by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	thymoma viral proto-oncogene 1	Mus musculus	86-90
26528352-5	2015	RESULTS: For the established I/R injury model, apelin-13 and SB216763 (GSK-3beta inhibitor) significantly reduced the infarct size (p &lt; 0.05), which could be abolished by LY294002 (PI3K inhibitor), PD98059 (MEK inhibitor) and atractyloside (mPTP accelerator).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	glycogen synthase kinase 3 beta	Rattus norvegicus	71-80
26528352-6	2015	The enhanced expression levels of p-Akt, p-ERK and p-GSK-3beta caused by apelin-13 (p &lt; 0.05) could be counteracted by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Rattus norvegicus	36-39
26528352-6	2015	The enhanced expression levels of p-Akt, p-ERK and p-GSK-3beta caused by apelin-13 (p &lt; 0.05) could be counteracted by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	glycogen synthase kinase 3 beta	Rattus norvegicus	53-62
26256949-8	2015	Inhibition of endogenous Akt by LY294002 resulted in decreased expression of Sox2, ALDH1, and CD133, leading to enhancement of cobalt chloride-mediated apoptotic events due to altered ratio of bcl-2 to bax expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	25-28
26310353-8	2015	The use of the AKT inhibitor, LY294002, in combination with cisplatin, induced an increase in apoptosis compared to treatment with cisplatin alone, although this effect was not as prominent as that exerted by butein in combination with cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	15-18
26513500-11	2015	The IGF-1 effect on MMP-2 was abolished by an IGF-1R blocking antibody, alphaIR3, as well as by the PI3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	insulin like growth factor 1	Homo sapiens	4-9
26513500-11	2015	The IGF-1 effect on MMP-2 was abolished by an IGF-1R blocking antibody, alphaIR3, as well as by the PI3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	matrix metallopeptidase 2	Homo sapiens	20-25
26513500-12	2015	The IGF-1 increased the migratory capacity of MGCs, which was blocked by the GM6001 MMP inhibitor, LY294002 and alphaIR3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	insulin like growth factor 1	Homo sapiens	4-9
25921464-5	2015	We showed that CORM-2-induced HO-1 protein and mRNA levels were inhibited by the inhibitor of c-Src (PP1 or SU6656), EGFR (AG1478), PI3K (LY294002), Akt (SH-5), JNK1/2 (SP600125), or p38 MAPK (SB202190) and transfection with siRNA of c-Src, EGFR, Akt, p38, JNK2, or Nrf2 in HTSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	heme oxygenase 1	Homo sapiens	30-34
26225471-6	2015	Inhibiting the Akt activation by the PI3K inhibitor LY294002 markedly enhanced GRP78 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	15-18
26225471-6	2015	Inhibiting the Akt activation by the PI3K inhibitor LY294002 markedly enhanced GRP78 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	heat shock protein family A (Hsp70) member 5	Homo sapiens	79-84
25860846-7	2015	LY294002 (an AKT inhibitor) addition enhanced caudation-induced AKT inhibition, indicating that caudatin inhibited U251 cells growth in an AKT-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	13-16
25860846-7	2015	LY294002 (an AKT inhibitor) addition enhanced caudation-induced AKT inhibition, indicating that caudatin inhibited U251 cells growth in an AKT-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	64-67
25860846-7	2015	LY294002 (an AKT inhibitor) addition enhanced caudation-induced AKT inhibition, indicating that caudatin inhibited U251 cells growth in an AKT-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	64-67
25869596-5	2015	Moreover, GB-induced reduction in expression of RTP801 was blocked by application of LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	119-148
26310574-9	2015	Folic acid also promoted the activation of the Akt pathway, and this effect was inhibited by treatment of the C2C12 cells with LY294002 (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	thymoma viral proto-oncogene 1	Mus musculus	47-50
26310574-9	2015	Folic acid also promoted the activation of the Akt pathway, and this effect was inhibited by treatment of the C2C12 cells with LY294002 (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	thymoma viral proto-oncogene 1	Mus musculus	137-140
26256949-8	2015	Inhibition of endogenous Akt by LY294002 resulted in decreased expression of Sox2, ALDH1, and CD133, leading to enhancement of cobalt chloride-mediated apoptotic events due to altered ratio of bcl-2 to bax expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	SRY-box transcription factor 2	Homo sapiens	77-81
26256949-8	2015	Inhibition of endogenous Akt by LY294002 resulted in decreased expression of Sox2, ALDH1, and CD133, leading to enhancement of cobalt chloride-mediated apoptotic events due to altered ratio of bcl-2 to bax expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	aldehyde dehydrogenase 1 family member A1	Homo sapiens	83-88
26256949-8	2015	Inhibition of endogenous Akt by LY294002 resulted in decreased expression of Sox2, ALDH1, and CD133, leading to enhancement of cobalt chloride-mediated apoptotic events due to altered ratio of bcl-2 to bax expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	prominin 1	Homo sapiens	94-99
26256949-8	2015	Inhibition of endogenous Akt by LY294002 resulted in decreased expression of Sox2, ALDH1, and CD133, leading to enhancement of cobalt chloride-mediated apoptotic events due to altered ratio of bcl-2 to bax expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	BCL2 apoptosis regulator	Homo sapiens	193-198
26256949-8	2015	Inhibition of endogenous Akt by LY294002 resulted in decreased expression of Sox2, ALDH1, and CD133, leading to enhancement of cobalt chloride-mediated apoptotic events due to altered ratio of bcl-2 to bax expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	BCL2 associated X, apoptosis regulator	Homo sapiens	202-205
26422672-5	2015	Am80-induced increase in nNOS protein expression was attenuated by LY294002, SP600125 and SB203580, whereas increase in nNOS mRNA expression was attenuated only by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	nitric oxide synthase 1	Homo sapiens	25-29
26422672-5	2015	Am80-induced increase in nNOS protein expression was attenuated by LY294002, SP600125 and SB203580, whereas increase in nNOS mRNA expression was attenuated only by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	nitric oxide synthase 1	Homo sapiens	120-124
26422672-6	2015	Am80-induced activation of JNK and p38 MAPK was blocked by LY294002, suggesting that these kinases acted downstream of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	mitogen-activated protein kinase 8	Homo sapiens	27-30
26422672-6	2015	Am80-induced activation of JNK and p38 MAPK was blocked by LY294002, suggesting that these kinases acted downstream of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	mitogen-activated protein kinase 14	Homo sapiens	35-43
26092426-8	2015	Furthermore, LY294002, the phosphoinositide 3-kinase (PI3-K) inhibitor, reversed the effects of GW7647 on the BACE-1 activity and the levels of sAPPbeta and Abeta42.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	27-52
26092426-8	2015	Furthermore, LY294002, the phosphoinositide 3-kinase (PI3-K) inhibitor, reversed the effects of GW7647 on the BACE-1 activity and the levels of sAPPbeta and Abeta42.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	beta-secretase 1	Homo sapiens	110-116
26259977-7	2015	The HGF-mediated LCN2 protein level was decreased with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	hepatocyte growth factor	Homo sapiens	4-7
26259977-7	2015	The HGF-mediated LCN2 protein level was decreased with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	lipocalin 2	Homo sapiens	17-21
26259977-8	2015	Also, the HGF-mediated MMP9 was decreased with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	hepatocyte growth factor	Homo sapiens	10-13
26259977-8	2015	Also, the HGF-mediated MMP9 was decreased with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	matrix metallopeptidase 9	Homo sapiens	23-27
26374481-7	2015	RESULTS: n-3 PUFAs reduced brain tissue loss at 7 days after H/I and improved neurological outcomes, whereas inhibition of PI3K/Akt signaling by LY294002 partially abrogated this neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	AKT serine/threonine kinase 1	Rattus norvegicus	128-131
26420965-15	2015	Moreover, Akt inhibition by Ly294002 could not prevent but led to enhanced G0/G1 arrest and apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	10-13
26623104-5	2015	In the HCC827 cells, the effect of PI3K pathway inhibitor LY294002 on the expressions of PI3K/Akt/mTOR pathway components under the effect of PEBP4 was determined using Western blotting, and the effects of LY294002 on the cell viability, proliferation, and migration capabilities under the overexpression of PEBP4 were determined using MTT method, flow cytometry, and Transwell migration assay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Homo sapiens	94-97
26623104-5	2015	In the HCC827 cells, the effect of PI3K pathway inhibitor LY294002 on the expressions of PI3K/Akt/mTOR pathway components under the effect of PEBP4 was determined using Western blotting, and the effects of LY294002 on the cell viability, proliferation, and migration capabilities under the overexpression of PEBP4 were determined using MTT method, flow cytometry, and Transwell migration assay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	mechanistic target of rapamycin kinase	Homo sapiens	98-102
26623104-5	2015	In the HCC827 cells, the effect of PI3K pathway inhibitor LY294002 on the expressions of PI3K/Akt/mTOR pathway components under the effect of PEBP4 was determined using Western blotting, and the effects of LY294002 on the cell viability, proliferation, and migration capabilities under the overexpression of PEBP4 were determined using MTT method, flow cytometry, and Transwell migration assay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	phosphatidylethanolamine binding protein 4	Homo sapiens	142-147
26623104-5	2015	In the HCC827 cells, the effect of PI3K pathway inhibitor LY294002 on the expressions of PI3K/Akt/mTOR pathway components under the effect of PEBP4 was determined using Western blotting, and the effects of LY294002 on the cell viability, proliferation, and migration capabilities under the overexpression of PEBP4 were determined using MTT method, flow cytometry, and Transwell migration assay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	phosphatidylethanolamine binding protein 4	Homo sapiens	308-313
26623104-8	2015	Treatment with LY294002 significantly inhibited the protein expressions of p-Akt and p-mTOR in HCC827 cells (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	77-80
26623104-8	2015	Treatment with LY294002 significantly inhibited the protein expressions of p-Akt and p-mTOR in HCC827 cells (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mechanistic target of rapamycin kinase	Homo sapiens	87-91
26623104-10	2015	As shown by MTT, flow cytometry, and Transwell migration assay, both LY294002 and RAPA could significantly lower the viability of HCC827 cells and inhibit their proliferation and invasion (P&lt;0.05); meanwhile, they could reverse the effect of PEBP4 in promoting the proliferation and migration of HCC827 cells (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	phosphatidylethanolamine binding protein 4	Homo sapiens	245-250
26411419-8	2015	And the PI3K/Akt inhibitor, LY294002, markedly deteriorated the cisplatin-mediated viability reduction of Hela or Caski cells, indicating the involvement of PI3K/Akt pathway in the cisplatin resistance in cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	13-16
26411419-8	2015	And the PI3K/Akt inhibitor, LY294002, markedly deteriorated the cisplatin-mediated viability reduction of Hela or Caski cells, indicating the involvement of PI3K/Akt pathway in the cisplatin resistance in cervical cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	162-165
25917210-10	2015	However, inhibitors of PI3K/AKT and ERK1/2 (LY294002 or U0126) not only suppressed geraniin-induced nuclear translocation of Nrf2 but also abolished the expression of HO-1, NQO1 and GSH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	28-31
26271595-9	2015	Furthermore, Li showed obvious protective effects against MA toxicity and LY294002 (Akt inhibitor) suppressed the protective effects of Li.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Rattus norvegicus	84-87
26211446-13	2015	However, the beneficial effects of betaE2 were markedly suppressed by pretreatment with LY294002 or ICI182780, specific inhibitors of the phosphatidylinositol 3-kinase-Akt (PI3K/AKT), and estrogen receptor (ER) signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Rattus norvegicus	168-171
26211446-13	2015	However, the beneficial effects of betaE2 were markedly suppressed by pretreatment with LY294002 or ICI182780, specific inhibitors of the phosphatidylinositol 3-kinase-Akt (PI3K/AKT), and estrogen receptor (ER) signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	173-181
26211446-13	2015	However, the beneficial effects of betaE2 were markedly suppressed by pretreatment with LY294002 or ICI182780, specific inhibitors of the phosphatidylinositol 3-kinase-Akt (PI3K/AKT), and estrogen receptor (ER) signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	estrogen receptor 1	Rattus norvegicus	188-205
26211446-13	2015	However, the beneficial effects of betaE2 were markedly suppressed by pretreatment with LY294002 or ICI182780, specific inhibitors of the phosphatidylinositol 3-kinase-Akt (PI3K/AKT), and estrogen receptor (ER) signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	estrogen receptor 1	Rattus norvegicus	207-209
26398523-7	2015	In contrast, both the PI3-kinase (PI3K) inhibitor (LY294002) and AKT inhibitor (perifosine) obviously inhibited the restoration of Rev-4F on EPCs impaired by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	tumor necrosis factor	Mus musculus	158-167
26366999-5	2015	In contrast, LY294002, a specific inhibitor of PI3K/AKT, reduced the level of AKT phosphorylation and GAP-43 expression, increased active caspase-3 expression and thus significantly weakened IL-10-mediated protective effect in the OGD-induced injury model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	52-55
26366999-5	2015	In contrast, LY294002, a specific inhibitor of PI3K/AKT, reduced the level of AKT phosphorylation and GAP-43 expression, increased active caspase-3 expression and thus significantly weakened IL-10-mediated protective effect in the OGD-induced injury model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	78-81
26366999-5	2015	In contrast, LY294002, a specific inhibitor of PI3K/AKT, reduced the level of AKT phosphorylation and GAP-43 expression, increased active caspase-3 expression and thus significantly weakened IL-10-mediated protective effect in the OGD-induced injury model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	growth associated protein 43	Homo sapiens	102-108
26366999-5	2015	In contrast, LY294002, a specific inhibitor of PI3K/AKT, reduced the level of AKT phosphorylation and GAP-43 expression, increased active caspase-3 expression and thus significantly weakened IL-10-mediated protective effect in the OGD-induced injury model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	caspase 3	Homo sapiens	138-147
26366999-5	2015	In contrast, LY294002, a specific inhibitor of PI3K/AKT, reduced the level of AKT phosphorylation and GAP-43 expression, increased active caspase-3 expression and thus significantly weakened IL-10-mediated protective effect in the OGD-induced injury model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	interleukin 10	Homo sapiens	191-196
26356837-7	2015	Inhibition of MEK1/2/ERK1/2 (1 muM U0126) and PI-3K/Akt (10 muM LY294002) signaling showed that the MEK1/2/ERK1/2 pathway via GSK-3beta exclusively was responsible for cardioprotection as an addition of U0126 prevented estrogen-induced GSK-3beta increased phosphorylation, resistance to mitochondrial Ca2+-overload, functional recovery and protection against infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	thymoma viral proto-oncogene 1	Mus musculus	52-55
26356837-7	2015	Inhibition of MEK1/2/ERK1/2 (1 muM U0126) and PI-3K/Akt (10 muM LY294002) signaling showed that the MEK1/2/ERK1/2 pathway via GSK-3beta exclusively was responsible for cardioprotection as an addition of U0126 prevented estrogen-induced GSK-3beta increased phosphorylation, resistance to mitochondrial Ca2+-overload, functional recovery and protection against infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	mitogen-activated protein kinase kinase 1	Mus musculus	100-106
26356837-7	2015	Inhibition of MEK1/2/ERK1/2 (1 muM U0126) and PI-3K/Akt (10 muM LY294002) signaling showed that the MEK1/2/ERK1/2 pathway via GSK-3beta exclusively was responsible for cardioprotection as an addition of U0126 prevented estrogen-induced GSK-3beta increased phosphorylation, resistance to mitochondrial Ca2+-overload, functional recovery and protection against infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	mitogen-activated protein kinase 3	Mus musculus	107-113
26356837-7	2015	Inhibition of MEK1/2/ERK1/2 (1 muM U0126) and PI-3K/Akt (10 muM LY294002) signaling showed that the MEK1/2/ERK1/2 pathway via GSK-3beta exclusively was responsible for cardioprotection as an addition of U0126 prevented estrogen-induced GSK-3beta increased phosphorylation, resistance to mitochondrial Ca2+-overload, functional recovery and protection against infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	glycogen synthase kinase 3 beta	Mus musculus	126-135
26356837-7	2015	Inhibition of MEK1/2/ERK1/2 (1 muM U0126) and PI-3K/Akt (10 muM LY294002) signaling showed that the MEK1/2/ERK1/2 pathway via GSK-3beta exclusively was responsible for cardioprotection as an addition of U0126 prevented estrogen-induced GSK-3beta increased phosphorylation, resistance to mitochondrial Ca2+-overload, functional recovery and protection against infarction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	glycogen synthase kinase 3 beta	Mus musculus	236-245
26027660-9	2015	Treatment with rapamycin or RAD001 significantly increased the phosphorylation of AKT in both LKB1 wild-type and LKB1 mutant NSCLC cells, which was attenuated by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	AKT serine/threonine kinase 1	Homo sapiens	82-85
26027660-9	2015	Treatment with rapamycin or RAD001 significantly increased the phosphorylation of AKT in both LKB1 wild-type and LKB1 mutant NSCLC cells, which was attenuated by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	serine/threonine kinase 11	Homo sapiens	94-98
26027660-9	2015	Treatment with rapamycin or RAD001 significantly increased the phosphorylation of AKT in both LKB1 wild-type and LKB1 mutant NSCLC cells, which was attenuated by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	serine/threonine kinase 11	Homo sapiens	113-117
26027660-10	2015	Furthermore, RAD001 combined with LY294002 markedly enhanced the growth inhibition on LKB1 wild-type H1792 cells and LKB1 mutant A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	serine/threonine kinase 11	Homo sapiens	86-90
26027660-10	2015	Furthermore, RAD001 combined with LY294002 markedly enhanced the growth inhibition on LKB1 wild-type H1792 cells and LKB1 mutant A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	serine/threonine kinase 11	Homo sapiens	117-121
25989537-6	2015	RESULTS: SLE serum promoted senescence of MSCs, which was reversed by the phosphatidylinositol 3-kinase (PI3K)/Akt signaling inhibitor LY294002 but not by the JAK/STAT inhibitor AG490 and not by the MEK/ERK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	74-103
25989537-6	2015	RESULTS: SLE serum promoted senescence of MSCs, which was reversed by the phosphatidylinositol 3-kinase (PI3K)/Akt signaling inhibitor LY294002 but not by the JAK/STAT inhibitor AG490 and not by the MEK/ERK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Homo sapiens	111-114
25989537-9	2015	Inhibition of PI3K/Akt signaling with LY294002 reduced leptin- and NAP-2-induced senescence in MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	19-22
25989537-9	2015	Inhibition of PI3K/Akt signaling with LY294002 reduced leptin- and NAP-2-induced senescence in MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	leptin	Homo sapiens	55-61
25989537-9	2015	Inhibition of PI3K/Akt signaling with LY294002 reduced leptin- and NAP-2-induced senescence in MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	pro-platelet basic protein	Homo sapiens	67-72
26391229-7	2015	Furthermore, ApoJ overexpression increased phosphorylation of Akt, and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 diminished the antioxidant effects of ApoJ, and prevented the protective effect of ApoJ against the cytotoxicity of AngII.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	clusterin	Rattus norvegicus	169-173
26391229-7	2015	Furthermore, ApoJ overexpression increased phosphorylation of Akt, and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 diminished the antioxidant effects of ApoJ, and prevented the protective effect of ApoJ against the cytotoxicity of AngII.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	clusterin	Rattus norvegicus	169-173
26391229-7	2015	Furthermore, ApoJ overexpression increased phosphorylation of Akt, and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 diminished the antioxidant effects of ApoJ, and prevented the protective effect of ApoJ against the cytotoxicity of AngII.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	angiotensinogen	Rattus norvegicus	247-252
26379195-11	2015	Especially, by using selective LY294002 inhibitor, we demonstrated that the most involved pathway in the SGK-1 mediated process of protection was PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	serum/glucocorticoid regulated kinase 1	Homo sapiens	105-110
25917210-10	2015	However, inhibitors of PI3K/AKT and ERK1/2 (LY294002 or U0126) not only suppressed geraniin-induced nuclear translocation of Nrf2 but also abolished the expression of HO-1, NQO1 and GSH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	mitogen-activated protein kinase 3	Homo sapiens	36-42
25917210-10	2015	However, inhibitors of PI3K/AKT and ERK1/2 (LY294002 or U0126) not only suppressed geraniin-induced nuclear translocation of Nrf2 but also abolished the expression of HO-1, NQO1 and GSH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	NFE2 like bZIP transcription factor 2	Homo sapiens	125-129
25917210-10	2015	However, inhibitors of PI3K/AKT and ERK1/2 (LY294002 or U0126) not only suppressed geraniin-induced nuclear translocation of Nrf2 but also abolished the expression of HO-1, NQO1 and GSH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	heme oxygenase 1	Homo sapiens	167-171
25917210-10	2015	However, inhibitors of PI3K/AKT and ERK1/2 (LY294002 or U0126) not only suppressed geraniin-induced nuclear translocation of Nrf2 but also abolished the expression of HO-1, NQO1 and GSH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	NAD(P)H quinone dehydrogenase 1	Homo sapiens	173-177
25882870-19	2015	However, the inhibition of Erk/Akt signaling pathways by U0126, a MEK-Erk inhibitor and LY294002, a PI3Kinase-Akt inhibitor, augmented TGF-beta1-induced apoptosis in OBA9 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Homo sapiens	110-113
25724443-4	2015	Moreover, our results showed that icariin postconditioning exerts cardioprotective effect against myocardial I/R injury through activating PI3K/Akt using PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	AKT serine/threonine kinase 1	Rattus norvegicus	144-147
25724443-4	2015	Moreover, our results showed that icariin postconditioning exerts cardioprotective effect against myocardial I/R injury through activating PI3K/Akt using PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
26459480-4	2015	In the presence of PI3K inhibitor LY294002 preventing protein kinase Akt activation, the protective effect of GM1 significantly decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Rattus norvegicus	69-72
25882870-19	2015	However, the inhibition of Erk/Akt signaling pathways by U0126, a MEK-Erk inhibitor and LY294002, a PI3Kinase-Akt inhibitor, augmented TGF-beta1-induced apoptosis in OBA9 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	transforming growth factor beta 1	Homo sapiens	135-144
25487790-7	2015	Tumor migration and GDNF-RET-AKT activation was inhibited by the RET small-molecule inhibitor pyrazolopyrimidine-1 (PP1) and by the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	glial cell line derived neurotrophic factor	Mus musculus	20-24
26021820-11	2015	This phenomenon was confirmed with suppressed nuclear Nrf2 activation, and consequently diminished antioxidant genes in cells treated with respective pharmacological inhibitors (LY294002, GF109203X, and N-acetylcysteine).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	NFE2 like bZIP transcription factor 2	Homo sapiens	54-58
25487790-7	2015	Tumor migration and GDNF-RET-AKT activation was inhibited by the RET small-molecule inhibitor pyrazolopyrimidine-1 (PP1) and by the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	ret proto-oncogene	Mus musculus	25-28
25487790-7	2015	Tumor migration and GDNF-RET-AKT activation was inhibited by the RET small-molecule inhibitor pyrazolopyrimidine-1 (PP1) and by the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	thymoma viral proto-oncogene 1	Mus musculus	29-32
25487790-7	2015	Tumor migration and GDNF-RET-AKT activation was inhibited by the RET small-molecule inhibitor pyrazolopyrimidine-1 (PP1) and by the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	thymoma viral proto-oncogene 1	Mus musculus	132-135
26099282-10	2015	Finally, the regulation of VEGF was inhibited by LY294002 and PD98059, and their combination exhibited a synergistic effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	vascular endothelial growth factor A	Rattus norvegicus	27-31
26178664-7	2015	Of note, we also found that the activation of the PI3K/AKT signaling pathway was mediated by hTERT and that blocking this pathway using LY294002 inhibited hTERT expression, induced senescence and decreased the proliferation of MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	telomerase reverse transcriptase	Homo sapiens	93-98
26178664-7	2015	Of note, we also found that the activation of the PI3K/AKT signaling pathway was mediated by hTERT and that blocking this pathway using LY294002 inhibited hTERT expression, induced senescence and decreased the proliferation of MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	telomerase reverse transcriptase	Homo sapiens	155-160
26163884-12	2015	Importantly, the above effects of apelin were abolished by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	apelin	Mus musculus	34-40
25655569-12	2015	Moreover, the treatment of HepG2 cells with the PI3K inhibitor LY294002 led to reduced insulin promoter-activating ability accompanied by a decrease in PNPLA3 and SREBP-1c protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	insulin	Homo sapiens	87-94
25655569-12	2015	Moreover, the treatment of HepG2 cells with the PI3K inhibitor LY294002 led to reduced insulin promoter-activating ability accompanied by a decrease in PNPLA3 and SREBP-1c protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	patatin like phospholipase domain containing 3	Homo sapiens	152-158
25655569-12	2015	Moreover, the treatment of HepG2 cells with the PI3K inhibitor LY294002 led to reduced insulin promoter-activating ability accompanied by a decrease in PNPLA3 and SREBP-1c protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	sterol regulatory element binding transcription factor 1	Homo sapiens	163-171
26062523-7	2015	Notably, interruption of the AKT pathway by treatment with LY294002, a specific PI3K inhibitor, attenuated IRX2-induced cell proliferation and invasive ability, and the upregulation of MMP2 and VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	29-32
26062523-7	2015	Notably, interruption of the AKT pathway by treatment with LY294002, a specific PI3K inhibitor, attenuated IRX2-induced cell proliferation and invasive ability, and the upregulation of MMP2 and VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	iroquois homeobox 2	Homo sapiens	107-111
26062523-7	2015	Notably, interruption of the AKT pathway by treatment with LY294002, a specific PI3K inhibitor, attenuated IRX2-induced cell proliferation and invasive ability, and the upregulation of MMP2 and VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	matrix metallopeptidase 2	Homo sapiens	185-189
26062523-7	2015	Notably, interruption of the AKT pathway by treatment with LY294002, a specific PI3K inhibitor, attenuated IRX2-induced cell proliferation and invasive ability, and the upregulation of MMP2 and VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	vascular endothelial growth factor A	Homo sapiens	194-198
26617788-8	2015	Furthermore, the expression of AK056155 was reduced with treatment of PI3K inhibitor (LY294002) or AKT inhibitor (GDC-0068) in combination with TGF-beta1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	transforming growth factor beta 1	Homo sapiens	144-153
25644787-7	2015	Furthermore, exposure to PCB118 was associated with a significant increase of the protein levels of p-Akt and p-FoxO3a, and these effects were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Homo sapiens	102-105
25644787-7	2015	Furthermore, exposure to PCB118 was associated with a significant increase of the protein levels of p-Akt and p-FoxO3a, and these effects were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	forkhead box O3	Homo sapiens	112-118
25925728-13	2015	Pretreatment with PI3K inhibitors, LY294002 and wortmannin, as well as Akt siRNA, decreased ghrelin-induced Akt phosphorylation, Snail promoter binding activity and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	108-111
25925728-13	2015	Pretreatment with PI3K inhibitors, LY294002 and wortmannin, as well as Akt siRNA, decreased ghrelin-induced Akt phosphorylation, Snail promoter binding activity and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	snail family transcriptional repressor 1	Homo sapiens	129-134
26255195-6	2015	Moreover, rutin activated both the protein Akt/mTOR and the extracellular signal-regulated kinase (ERK1/2) signaling pathways and the neuroprotective effects of rutin were blocked by either the specific PI3K inhibitor LY294002 or the MAPK pathway inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	mitogen activated protein kinase 3	Rattus norvegicus	99-105
26492644-11	2015	Western blot analysis also showed that BE increased the phosphorylation of Akt and eNOS in H9c2 cells, and the protective effects of BE were partially inhibited by the phosphatidylinositol 3"-kinase (PI3K) specific inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	225-233	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	168-198
26187353-11	2015	In contrast, LY294002, the PI3k/Akt pathway inhibitor, abolished SAL-induced phosphorylation and expression of eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	thymoma viral proto-oncogene 1	Mus musculus	32-35
26008990-7	2015	NO production and eNOS phosphorylation in response to Pts were significantly abolished by the phosphoinositide 3-kinase (PI3K)/Akt inhibitor LY294002, but not by the ERalpha antagonist ICI182780.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Homo sapiens	127-130
26324256-8	2015	Furthermore, PTX and LY-294002 (PI3K inhibitor) prevented S1PR2/3-mediated BMM migration, and Rac1 activation by S1P was inhibited by JTE-013, CAY-10444 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-30	sphingosine-1-phosphate receptor 2	Mus musculus	58-63
26324256-8	2015	Furthermore, PTX and LY-294002 (PI3K inhibitor) prevented S1PR2/3-mediated BMM migration, and Rac1 activation by S1P was inhibited by JTE-013, CAY-10444 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-30	sphingosine-1-phosphate receptor 1	Mus musculus	58-61
26324256-8	2015	Furthermore, PTX and LY-294002 (PI3K inhibitor) prevented S1PR2/3-mediated BMM migration, and Rac1 activation by S1P was inhibited by JTE-013, CAY-10444 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	Rac family small GTPase 1	Mus musculus	94-98
26324256-8	2015	Furthermore, PTX and LY-294002 (PI3K inhibitor) prevented S1PR2/3-mediated BMM migration, and Rac1 activation by S1P was inhibited by JTE-013, CAY-10444 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	sphingosine-1-phosphate receptor 1	Mus musculus	58-61
25935536-8	2015	Additionally, LY294002 (Akt pathway inhibitor) or U0126 (ERK pathway inhibitor) significantly suppressed SOX-2-overexpression-induced migration and invasion in SiHa cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	24-27
25935536-8	2015	Additionally, LY294002 (Akt pathway inhibitor) or U0126 (ERK pathway inhibitor) significantly suppressed SOX-2-overexpression-induced migration and invasion in SiHa cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	SRY-box transcription factor 2	Homo sapiens	105-110
26089345-8	2015	Treatment with LY294002 rescued the distribution of E-cadherin and beta-catenin at cell-cell membranes, restored total beta-catenin pool, but had no effect on protein level of E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cadherin 1	Mus musculus	52-62
26089345-8	2015	Treatment with LY294002 rescued the distribution of E-cadherin and beta-catenin at cell-cell membranes, restored total beta-catenin pool, but had no effect on protein level of E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	catenin (cadherin associated protein), beta 1	Mus musculus	67-79
26089345-8	2015	Treatment with LY294002 rescued the distribution of E-cadherin and beta-catenin at cell-cell membranes, restored total beta-catenin pool, but had no effect on protein level of E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	catenin (cadherin associated protein), beta 1	Mus musculus	119-131
26089345-9	2015	At the same time, LY294002 also inhibited phosphorylation of ERK, glycogen synthase kinase3beta and tyrosine 654 of beta-catenin induced by TDI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	glycogen synthase kinase 3 beta	Mus musculus	66-95
26089345-9	2015	At the same time, LY294002 also inhibited phosphorylation of ERK, glycogen synthase kinase3beta and tyrosine 654 of beta-catenin induced by TDI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	catenin (cadherin associated protein), beta 1	Mus musculus	116-128
26187353-11	2015	In contrast, LY294002, the PI3k/Akt pathway inhibitor, abolished SAL-induced phosphorylation and expression of eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	nitric oxide synthase 3, endothelial cell	Mus musculus	111-115
26289587-11	2015	In spinal cord culture, the inhibitors to PLC (U73122), PKC (bisindolylmaleimide I), and PI3K (LY294002), but not MEK (PD98059) blocked BDNF-induced NR1 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	brain-derived neurotrophic factor	Rattus norvegicus	136-140
26408613-7	2015	The effect of OST on p-Akt phosphorylation in HT22 cells was attenuated in the presence of PI3K specific inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	thymoma viral proto-oncogene 1	Mus musculus	23-26
26317415-9	2015	The increased ABCA1 expression and cholesterol efflux by R5-6- and R5-6C-conditioned media were diminished by Sp1 or PI3K inhibitors mithramycin A and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	ATP binding cassette subfamily A member 1	Homo sapiens	14-19
25979858-10	2015	CSE inhibitor PAG and Akt inhibitor LY294002 could reverse the protective effects of SPRC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
25934572-8	2015	Treatment with LY294002, a specific Akt inhibitor, restored baicalin-induced melanogenesis inhibition and abolished MITF and tyrosinase downregulation by baicalin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	thymoma viral proto-oncogene 1	Mus musculus	36-39
25934572-8	2015	Treatment with LY294002, a specific Akt inhibitor, restored baicalin-induced melanogenesis inhibition and abolished MITF and tyrosinase downregulation by baicalin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	melanogenesis associated transcription factor	Mus musculus	116-120
25934572-8	2015	Treatment with LY294002, a specific Akt inhibitor, restored baicalin-induced melanogenesis inhibition and abolished MITF and tyrosinase downregulation by baicalin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	tyrosinase	Mus musculus	125-135
26278786-8	2015	Chemical inhibitors for AKT (LY294002) and PKR (C16) disrupted their angiogenic potentials, suggesting that RNF213 and its upstream pathways cooperatively organize the process of angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	24-27
26278786-8	2015	Chemical inhibitors for AKT (LY294002) and PKR (C16) disrupted their angiogenic potentials, suggesting that RNF213 and its upstream pathways cooperatively organize the process of angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	ring finger protein 213	Homo sapiens	108-114
26116534-4	2015	The Netrin-1-induced RSC96 cells migration was significantly attenuated by inhibition of p38 and PI3K through pretreatment with SB203580 and LY294002 respectively, but not inhibition of MEK1/2 and JNK by U0126-EtOH and SP600125 individually.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	netrin 1	Rattus norvegicus	4-12
26005169-12	2015	Exogenous CT-1 induced nuclear translocation of endogenous CT-1, which was inhibited by BAPTA, the NOS inhibitor L-N(G)-Nitroarginine methyl ester (l-NAME), the radical scavenger N-(2-mercaptopropionyl)-glycine (NMPG) as well as the janus kinase 2 (JAK2) inhibitor AG490 and the PI3 kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	307-315	cardiotrophin 1	Mus musculus	10-14
26005169-12	2015	Exogenous CT-1 induced nuclear translocation of endogenous CT-1, which was inhibited by BAPTA, the NOS inhibitor L-N(G)-Nitroarginine methyl ester (l-NAME), the radical scavenger N-(2-mercaptopropionyl)-glycine (NMPG) as well as the janus kinase 2 (JAK2) inhibitor AG490 and the PI3 kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	307-315	cardiotrophin 1	Homo sapiens	59-63
26550160-12	2015	IL-8 induced cell proliferation, phosphorylation of Akt and GSK-3beta(ser9), inhibited apoptosis and Caspase3 expression in HUVECs, which were attenuated by anti-IL-8 or the Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	interleukin-8	Oryctolagus cuniculus	0-4
26550160-12	2015	IL-8 induced cell proliferation, phosphorylation of Akt and GSK-3beta(ser9), inhibited apoptosis and Caspase3 expression in HUVECs, which were attenuated by anti-IL-8 or the Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	interleukin-8	Oryctolagus cuniculus	162-166
26116534-4	2015	The Netrin-1-induced RSC96 cells migration was significantly attenuated by inhibition of p38 and PI3K through pretreatment with SB203580 and LY294002 respectively, but not inhibition of MEK1/2 and JNK by U0126-EtOH and SP600125 individually.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	mitogen activated protein kinase 14	Rattus norvegicus	89-92
26032505-0	2015	Sub-chronic administration of LY294002 sensitizes cervical cancer cells to chemotherapy by enhancing mitochondrial JNK signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	mitogen-activated protein kinase 8	Homo sapiens	115-118
25894538-10	2015	The effect of sRAGE reduction on TUNEL-positive myocytes and caspase-3 activity were abolished by PI3K inhibitor LY294002, but not ERK 1/2 inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	caspase 3	Mus musculus	61-70
25957836-7	2015	The increase of TH was also inhibited by SQ22536 (adenylyl cyclase inhibitor), H-89(PKA inhibitor) and LY294002 (phosphatidylinositol 3 kinase inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	tyrosine hydroxylase	Rattus norvegicus	16-18
26043797-8	2015	Pretreatment with the autophagy inhibitors LY294002, 3-methyladenine, chloroquine, and bafilomycin A1 enhanced the induction of apoptosis by MHY218, and this was accompanied by an increase in PARP cleavage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	poly(ADP-ribose) polymerase 1	Homo sapiens	192-196
26066464-6	2015	In addition, the blockage of PI3K/Akt by Ly294002 or knockdown of Akt by siRNA reduced the level of p-MDM2 and increased the level of p53.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	34-37
26031366-5	2015	The phosphatidylinositol 3-kinase inhibitor LY294002 was used to inhibit phosphorylation of Akt, to verify whether miR-20a affects HCC cell radioresistance through activating the PTEN/PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	92-95
26031366-10	2015	Additionally, the kinase inhibitor LY294002 could reverse the effect of miR-20a-induced radioresistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	microRNA 20a	Homo sapiens	72-79
26367737-8	2015	Interestingly, NO production and eNOS phosphorylation in response to Pic were significantly abolished by the phosphoinositide 3-kinase (PI3K)/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	AKT serine/threonine kinase 1	Homo sapiens	142-145
26052821-3	2015	Here, we propose a novel mechanism by which the PI3K/AKT pathway regulates NOTCH1 in T-ALL, starting from the evidence that the inhibition of PI3K/AKT signaling induced by treatment with LY294002 or transient transfection with a dominant negative AKT mutant downregulates NOTCH1 protein levels and activity, without affecting NOTCH1 transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	AKT serine/threonine kinase 1	Homo sapiens	53-56
26052821-3	2015	Here, we propose a novel mechanism by which the PI3K/AKT pathway regulates NOTCH1 in T-ALL, starting from the evidence that the inhibition of PI3K/AKT signaling induced by treatment with LY294002 or transient transfection with a dominant negative AKT mutant downregulates NOTCH1 protein levels and activity, without affecting NOTCH1 transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	notch receptor 1	Homo sapiens	75-81
26052821-3	2015	Here, we propose a novel mechanism by which the PI3K/AKT pathway regulates NOTCH1 in T-ALL, starting from the evidence that the inhibition of PI3K/AKT signaling induced by treatment with LY294002 or transient transfection with a dominant negative AKT mutant downregulates NOTCH1 protein levels and activity, without affecting NOTCH1 transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	AKT serine/threonine kinase 1	Homo sapiens	147-150
26052821-3	2015	Here, we propose a novel mechanism by which the PI3K/AKT pathway regulates NOTCH1 in T-ALL, starting from the evidence that the inhibition of PI3K/AKT signaling induced by treatment with LY294002 or transient transfection with a dominant negative AKT mutant downregulates NOTCH1 protein levels and activity, without affecting NOTCH1 transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	AKT serine/threonine kinase 1	Homo sapiens	147-150
25736988-5	2015	Inhibition of PI3K/Akt pathway by chemical LY294002 or Phosphase and tensin homology deleted on chromosome ten (PTEN) prevented the phenotypic transition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	19-22
26101183-5	2015	Furthermore, the Akt inhibitor, LY294002, partly eliminated the protective effect of puerarin on DEX-induced apoptosis, and puerarin combined with the JNK inhibitor, SP600125, suppressed DEX-induced apoptosis to a lesser extent than in the cells treated with SP600125 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	17-20
25754021-5	2015	The PI3K/AKT inhibitor LY294002 or the MEK/ERK inhibitor U0126 attenuated the effect of morroniside on human OA chondrocytes, indicating that the activation of AKT and ERK contributed to the regulation of morroniside in human OA chondrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	160-163
26006021-8	2015	In parallel with a decline in Akt expression and phosphorylation by MI, LY294002 injection resulted in significant suppression of connexin 43 and proangiogenic factor expression, and a reduction of angiogenesis and collateral circulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Sus scrofa	30-33
26039631-9	2015	IGF-1-mediated and TPO-mediated, but not epinephrine-mediated, enhancements in the presence of antiplatelet drugs were blocked by the PI3K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	insulin like growth factor 1	Homo sapiens	0-5
26039631-9	2015	IGF-1-mediated and TPO-mediated, but not epinephrine-mediated, enhancements in the presence of antiplatelet drugs were blocked by the PI3K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	thrombopoietin	Homo sapiens	19-22
26006021-8	2015	In parallel with a decline in Akt expression and phosphorylation by MI, LY294002 injection resulted in significant suppression of connexin 43 and proangiogenic factor expression, and a reduction of angiogenesis and collateral circulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	gap junction protein alpha 1	Sus scrofa	130-141
25955216-7	2015	LY294002, a specific inhibitor of PI3K, prevented the decline in Bcl-2 production and the increase in levels of beclin-1, class III PI3K and autophagy following Cd treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2, apoptosis regulator	Rattus norvegicus	65-70
25955216-7	2015	LY294002, a specific inhibitor of PI3K, prevented the decline in Bcl-2 production and the increase in levels of beclin-1, class III PI3K and autophagy following Cd treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	beclin 1	Rattus norvegicus	112-120
25957503-7	2015	Moreover, the inhibition of the activation of AKT with LY294002 significantly promoted the apoptosis and metastasis induced by baicalein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	46-49
26403728-5	2015	BrdU fluorescent labeling and scratch assay were performed to observe the proliferation and migration of CMECs following liraglutide treatment, and PI3K/Akt and MAPK/ERK pathway inhibitors LY294002 and PD98059, respectively, were used to further confirm the role of these signaling pathways in regulating the proliferation and migration of CMECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	Eph receptor B1	Rattus norvegicus	166-169
25903972-6	2015	Evodiamine reduced expression of phosphorylated AKT, and LY294002 potentiated evodiamine-induced apoptosis by regulating Mcl-1 protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	121-126
25906449-5	2015	Wortmannin and LY294002 blocked INGAP-PP effect on insulin secretion and glucokinase protein levels in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	glucokinase	Rattus norvegicus	73-84
25725335-8	2015	Furthermore, the neuroprotective effect of N2 was associated with the PI3K/Akt pathway which was proved by the use of PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	AKT serine/threonine kinase 1	Rattus norvegicus	75-78
26622553-7	2015	Furthermore, the proliferation and migration abilities of cells were attenuated following inhibition of the PI3K/AKT/mTOR pathway by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	AKT serine/threonine kinase 1	Homo sapiens	113-116
26622553-7	2015	Furthermore, the proliferation and migration abilities of cells were attenuated following inhibition of the PI3K/AKT/mTOR pathway by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	mechanistic target of rapamycin kinase	Homo sapiens	117-121
26223322-8	2015	Inhibition of integrin beta4 and Akt signalling using blocking antibody and the inhibitor LY294002, respectively, significantly attenuated p53(R248)-mediated ovarian cancer-mesothelial adhesion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	integrin subunit beta 4	Homo sapiens	14-28
26677708-7	2015	Both LY294002 and Pue can inhibit hypoxia-induced Bcl-2, up-regulation of P-AKT expression and down-regulation of Bax expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	BCL2, apoptosis regulator	Rattus norvegicus	50-55
26677708-7	2015	Both LY294002 and Pue can inhibit hypoxia-induced Bcl-2, up-regulation of P-AKT expression and down-regulation of Bax expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	AKT serine/threonine kinase 1	Rattus norvegicus	76-79
26677708-7	2015	Both LY294002 and Pue can inhibit hypoxia-induced Bcl-2, up-regulation of P-AKT expression and down-regulation of Bax expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	BCL2 associated X, apoptosis regulator	Rattus norvegicus	114-117
26677708-8	2015	Compared with the hypoxia + Pue group or the hypoxia + LY294002 group, the hypoxia + Pue + LY294002 group showed more significantly changes in Bcl-2, Bax, P-AKT expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	BCL2, apoptosis regulator	Rattus norvegicus	143-148
26677708-8	2015	Compared with the hypoxia + Pue group or the hypoxia + LY294002 group, the hypoxia + Pue + LY294002 group showed more significantly changes in Bcl-2, Bax, P-AKT expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	BCL2 associated X, apoptosis regulator	Rattus norvegicus	150-153
26677708-8	2015	Compared with the hypoxia + Pue group or the hypoxia + LY294002 group, the hypoxia + Pue + LY294002 group showed more significantly changes in Bcl-2, Bax, P-AKT expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	AKT serine/threonine kinase 1	Rattus norvegicus	157-160
26347199-9	2015	The employment of specific chemical inhibitors, SB203580, LY294002, PD98059, and AG490, demonstrated the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in the regulatory effect of UA on NOX4 activity and expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	Eph receptor B1	Rattus norvegicus	120-123
26347199-9	2015	The employment of specific chemical inhibitors, SB203580, LY294002, PD98059, and AG490, demonstrated the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in the regulatory effect of UA on NOX4 activity and expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	mitogen-activated protein kinase 1	Homo sapiens	143-147
26223322-8	2015	Inhibition of integrin beta4 and Akt signalling using blocking antibody and the inhibitor LY294002, respectively, significantly attenuated p53(R248)-mediated ovarian cancer-mesothelial adhesion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 1	Homo sapiens	33-36
26223322-8	2015	Inhibition of integrin beta4 and Akt signalling using blocking antibody and the inhibitor LY294002, respectively, significantly attenuated p53(R248)-mediated ovarian cancer-mesothelial adhesion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	tumor protein p53	Homo sapiens	139-142
25968579-7	2015	Incubation with parthenolide abolished LIF-induced glucose uptake and STAT3 Tyr(705) P, whereas incubation with LY-294002 and wortmannin suppressed both basal and LIF-induced glucose uptake and Akt Ser(473) P, indicating that JAK and PI 3-kinase signaling is required for LIF-stimulated glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-121	leukemia inhibitory factor	Mus musculus	163-166
25735397-12	2015	SB203580, GF109203, and LY294002 reduced fluvastatin-induced TFPI upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	tissue factor pathway inhibitor	Homo sapiens	61-65
25986738-6	2015	The PI3K inhibitor LY-294002 inhibited phosphorylation of Akt and GSK-3beta as well as blocking EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	AKT serine/threonine kinase 1	Rattus norvegicus	58-61
25986738-6	2015	The PI3K inhibitor LY-294002 inhibited phosphorylation of Akt and GSK-3beta as well as blocking EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	glycogen synthase kinase 3 beta	Rattus norvegicus	66-75
25968579-7	2015	Incubation with parthenolide abolished LIF-induced glucose uptake and STAT3 Tyr(705) P, whereas incubation with LY-294002 and wortmannin suppressed both basal and LIF-induced glucose uptake and Akt Ser(473) P, indicating that JAK and PI 3-kinase signaling is required for LIF-stimulated glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-121	thymoma viral proto-oncogene 1	Mus musculus	194-197
25968579-7	2015	Incubation with parthenolide abolished LIF-induced glucose uptake and STAT3 Tyr(705) P, whereas incubation with LY-294002 and wortmannin suppressed both basal and LIF-induced glucose uptake and Akt Ser(473) P, indicating that JAK and PI 3-kinase signaling is required for LIF-stimulated glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-121	leukemia inhibitory factor	Mus musculus	163-166
25212570-6	2015	LY294002 (PI3K inhibitor) decreased p-Akt and Akt, resulting in enhancing MEIB-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	38-41
25857968-2	2015	We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	387-395	tumor necrosis factor	Homo sapiens	203-212
26893923-6	2015	Ang II also increased ER stress markers, such as phospho-PERK, phospho-eIF2alpha, and ATF4 proteins of podocyte, significantly in a dose-dependent manner at 24 h. Increased phospho-PERK and ATF4 proteins were further augmented by phosphoinositide 3 (PI3)-kinase inhibitor, LY294002, which suggested that Ang II could induce podocyte ER stress of PERK-eIF2alpha-ATF4 axis via PI3-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	273-281	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
26893923-6	2015	Ang II also increased ER stress markers, such as phospho-PERK, phospho-eIF2alpha, and ATF4 proteins of podocyte, significantly in a dose-dependent manner at 24 h. Increased phospho-PERK and ATF4 proteins were further augmented by phosphoinositide 3 (PI3)-kinase inhibitor, LY294002, which suggested that Ang II could induce podocyte ER stress of PERK-eIF2alpha-ATF4 axis via PI3-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	273-281	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	181-185
26893923-6	2015	Ang II also increased ER stress markers, such as phospho-PERK, phospho-eIF2alpha, and ATF4 proteins of podocyte, significantly in a dose-dependent manner at 24 h. Increased phospho-PERK and ATF4 proteins were further augmented by phosphoinositide 3 (PI3)-kinase inhibitor, LY294002, which suggested that Ang II could induce podocyte ER stress of PERK-eIF2alpha-ATF4 axis via PI3-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	273-281	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	181-185
26096047-8	2015	PI3K-specific inhibitor LY294002 only blocked the late phase of mTOR activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	mechanistic target of rapamycin kinase	Homo sapiens	64-68
25604781-7	2015	Hyperbaric oxygen preconditioning increased expression of HO-1, which was suppressed by PI3K inhibitor LY294002, Nrf2 knockout, and Akt inhibitor triciribine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	heme oxygenase 1	Mus musculus	58-62
25604781-8	2015	The expression of Nrf2 was enhanced by hyperbaric oxygen preconditioning, but decreased by LY294002 and triciribine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
25604781-9	2015	The Akt was also activated by hyperbaric oxygen preconditioning but suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	thymoma viral proto-oncogene 1	Mus musculus	4-7
25640606-6	2015	Inactivating these pathways using the PI3K/Akt pathway inhibitor LY294002 or the MAP kinase pathway inhibitor PD98059 renders the DU145-TxR cells more sensitive to paclitaxel.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	43-46
25738331-7	2015	LY294002, an Akt-inhibitor, was able to increase the inhibition of p-Akt through MeoTR and combination treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	13-16
25738331-7	2015	LY294002, an Akt-inhibitor, was able to increase the inhibition of p-Akt through MeoTR and combination treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	69-72
26328006-10	2015	The effects of BK-PC were abrogated by HOE140 (B2R antagonist) and LY294002 (Akt antagonist).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Homo sapiens	77-80
25912236-10	2015	The PI3K inhibitor, LY294002, also suppressed the IR-induced neurite outgrowth, the activation of p53, the expression of GAP-43 and Rab13, and the increase of Tuj-1 positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	transformation related protein 53	Mus musculus	98-101
25912236-10	2015	The PI3K inhibitor, LY294002, also suppressed the IR-induced neurite outgrowth, the activation of p53, the expression of GAP-43 and Rab13, and the increase of Tuj-1 positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	growth associated protein 43	Mus musculus	121-127
25912236-10	2015	The PI3K inhibitor, LY294002, also suppressed the IR-induced neurite outgrowth, the activation of p53, the expression of GAP-43 and Rab13, and the increase of Tuj-1 positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	RAB13, member RAS oncogene family	Mus musculus	132-137
25806690-9	2015	When they were treated with LY-294002, a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, cardioprotection by RvD1 was abrogated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-37	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	41-66
25806690-9	2015	When they were treated with LY-294002, a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, cardioprotection by RvD1 was abrogated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-37	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
26026718-8	2015	SDF-1 promoted F5M2 cell migration by activating the AKT and Wnt/beta-catenin signaling pathway, which was abrogated by preincubation with AMD3100 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	C-X-C motif chemokine ligand 12	Homo sapiens	0-5
26026718-8	2015	SDF-1 promoted F5M2 cell migration by activating the AKT and Wnt/beta-catenin signaling pathway, which was abrogated by preincubation with AMD3100 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	AKT serine/threonine kinase 1	Homo sapiens	53-56
26026718-8	2015	SDF-1 promoted F5M2 cell migration by activating the AKT and Wnt/beta-catenin signaling pathway, which was abrogated by preincubation with AMD3100 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	catenin beta 1	Homo sapiens	65-77
25212570-6	2015	LY294002 (PI3K inhibitor) decreased p-Akt and Akt, resulting in enhancing MEIB-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	46-49
25212570-8	2015	MEIB and LY294002 significantly increased Bax, thereby inducing the conformational change, mitochondrial translocation, and oligomerization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	BCL2 associated X, apoptosis regulator	Homo sapiens	42-45
26002630-8	2015	In addition, AM treatment increased the phosphorylation level of Akt in OPC cultures, and correspondingly, the PI3K/Akt inhibitor LY294002 blocked the AM-induced OPC differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
25912158-9	2015	The additions of pharmacological agents LY294002, SP600125, and CAY10585 were found to inhibit arecoline-induced S100A4 expression in OE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	S100 calcium binding protein A4	Homo sapiens	113-119
25912158-10	2015	CONCLUSION: Arecoline-induced S100A4 expression was down-regulated by LY294002, SP600125, or CAY10585 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	S100 calcium binding protein A4	Homo sapiens	30-36
26480649-8	2015	APP protein started to increase at 2 h, remained at a high level at 4, 8, 24 h, and then progressively increased at 48 and 72 h. In wortmannin and LY294002 group, CRMP-2 protein was not obviously changed at 4 h and 24 h after HI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	dihydropyrimidinase-like 2	Rattus norvegicus	163-169
26002630-8	2015	In addition, AM treatment increased the phosphorylation level of Akt in OPC cultures, and correspondingly, the PI3K/Akt inhibitor LY294002 blocked the AM-induced OPC differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
32262676-8	2015	Furthermore, the activation of the AKT signaling pathway was observed in BMSCs upon treatment with icariin, and these enhancement effects could be blocked by LY294002, which suggested that the AKT signaling pathway was involved in the osteogenic differentiation and angiogenic factor expression of BMSCs induced by icariin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	AKT serine/threonine kinase 1	Rattus norvegicus	35-38
26133970-9	2015	It also instigated phosphorylation of Akt and eNOS in cultured HUVECs in a concentration-dependent manner and this was markedly suppressed by PP2, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	AKT serine/threonine kinase 1	Rattus norvegicus	38-41
26133970-9	2015	It also instigated phosphorylation of Akt and eNOS in cultured HUVECs in a concentration-dependent manner and this was markedly suppressed by PP2, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	nitric oxide synthase 3	Rattus norvegicus	46-50
32262676-8	2015	Furthermore, the activation of the AKT signaling pathway was observed in BMSCs upon treatment with icariin, and these enhancement effects could be blocked by LY294002, which suggested that the AKT signaling pathway was involved in the osteogenic differentiation and angiogenic factor expression of BMSCs induced by icariin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	AKT serine/threonine kinase 1	Rattus norvegicus	193-196
26279749-10	2015	The effects of BK-PC were abrogated by HOE140 (B2R antagonist) and LY294002 (Akt antagonist).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Homo sapiens	77-80
26093674-8	2015	Intrathecal administration of a potent PI3-kinase inhibitor (LY294002), a known GSK-3beta activator, significantly decreased GSK-3beta(P) expression levels in the dorsal horn.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	glycogen synthase kinase 3 beta	Homo sapiens	80-89
26093674-8	2015	Intrathecal administration of a potent PI3-kinase inhibitor (LY294002), a known GSK-3beta activator, significantly decreased GSK-3beta(P) expression levels in the dorsal horn.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	glycogen synthase kinase 3 beta	Homo sapiens	125-134
25388642-5	2015	In ex vivo tissue cultures p-AKT(Ser473) levels were increased upon irradiation and treatment with the PI3K inhibitor LY294002 inhibited both basal and irradiation induced AKT(Ser473) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	AKT serine/threonine kinase 1	Homo sapiens	29-32
25388642-5	2015	In ex vivo tissue cultures p-AKT(Ser473) levels were increased upon irradiation and treatment with the PI3K inhibitor LY294002 inhibited both basal and irradiation induced AKT(Ser473) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	AKT serine/threonine kinase 1	Homo sapiens	172-175
25896849-6	2015	The PI3 kinase inhibitor, LY294002, inhibited HO-1 induction by AscA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	heme oxygenase 1	Mus musculus	46-50
26061016-7	2015	Claudin-2 expression was decreased by LY-294002, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, and U0126, a MEK inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-47	claudin 2	Homo sapiens	0-9
26061016-7	2015	Claudin-2 expression was decreased by LY-294002, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, and U0126, a MEK inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-47	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	51-80
26061016-10	2015	Both LY-294002 and U0126 inhibited promoter activity of claudin-2, but quercetin did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-14	claudin 2	Homo sapiens	56-65
25644394-9	2015	The apoptosis rate decreased significantly in human neutrophils stimulated with anti-LAMP-2 antibody, and this effect was attenuated by the inhibitors of autophagy 3-methyladenine (3MA) and 2-morpholin-4-yl-8-phenylchromen-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-228	lysosomal associated membrane protein 2	Homo sapiens	85-91
25824534-8	2015	However, the anti-apoptotic effect conferred by BBR was blocked by Notch1 siRNA, Hes1 siRNA or LY294002 (the specific inhibitor of Akt signaling) in the cultured cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Rattus norvegicus	131-134
25821107-9	2015	Treatment of cervical cancer-derived cell lines with the PI3K inhibitor LY294002 resulted in a reduced AKT1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	103-107
25821107-11	2015	Treatment of the cells with LY294002 resulted in a G1 cell cycle arrest, a nuclear expression of p27(Kip1), and a cytoplasmic p27(Kip1) accumulation after subsequent treatment with MG132.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	zinc ribbon domain containing 2	Homo sapiens	97-100
25821107-11	2015	Treatment of the cells with LY294002 resulted in a G1 cell cycle arrest, a nuclear expression of p27(Kip1), and a cytoplasmic p27(Kip1) accumulation after subsequent treatment with MG132.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin dependent kinase inhibitor 1B	Homo sapiens	101-105
25821107-11	2015	Treatment of the cells with LY294002 resulted in a G1 cell cycle arrest, a nuclear expression of p27(Kip1), and a cytoplasmic p27(Kip1) accumulation after subsequent treatment with MG132.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	zinc ribbon domain containing 2	Homo sapiens	126-129
25821107-11	2015	Treatment of the cells with LY294002 resulted in a G1 cell cycle arrest, a nuclear expression of p27(Kip1), and a cytoplasmic p27(Kip1) accumulation after subsequent treatment with MG132.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin dependent kinase inhibitor 1B	Homo sapiens	130-134
25821107-12	2015	Additionally, we found that the synergistic effect of MG132 and LY294002 resulted in a sub-G1 cell cycle arrest and apoptosis induction through poly (ADP-ribose) polymerase (PARP) cleavage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	poly(ADP-ribose) polymerase 1	Homo sapiens	144-172
25821107-12	2015	Additionally, we found that the synergistic effect of MG132 and LY294002 resulted in a sub-G1 cell cycle arrest and apoptosis induction through poly (ADP-ribose) polymerase (PARP) cleavage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	poly(ADP-ribose) polymerase 1	Homo sapiens	174-178
25644394-9	2015	The apoptosis rate decreased significantly in human neutrophils stimulated with anti-LAMP-2 antibody, and this effect was attenuated by the inhibitors of autophagy 3-methyladenine (3MA) and 2-morpholin-4-yl-8-phenylchromen-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	230-238	lysosomal associated membrane protein 2	Homo sapiens	85-91
25614086-11	2015	Finally, LY294002, a phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, abolished the suppressive effect of TIP27 overexpression on PEPCK and G6Pase expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	JAZF zinc finger 1	Mus musculus	111-116
25773677-7	2015	Furthermore, activation of PAR-2 induced the activation of PI3K and AKT, and PI3K/AKT inhibitor LY294002 attenuated the invasion and migration of RCC cells stimulated by PAR-2 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	AKT serine/threonine kinase 1	Homo sapiens	82-85
25773677-7	2015	Furthermore, activation of PAR-2 induced the activation of PI3K and AKT, and PI3K/AKT inhibitor LY294002 attenuated the invasion and migration of RCC cells stimulated by PAR-2 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	F2R like trypsin receptor 1	Homo sapiens	170-175
26261538-3	2015	RESULTS: Stably transfected LNCaP cells that over expressed E6-AP had higher expression levels of PI3K, Akt, and mTOR than control LNCaP cells; MTT assay showed that E6-AP-LNCaP cells were more responsive to the inhibitory effect of LY294002; Matrigel invasion chamber assay revealed increased cell crawling and adhesiveness of E6-AP-LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	ubiquitin protein ligase E3A	Homo sapiens	60-65
26261538-3	2015	RESULTS: Stably transfected LNCaP cells that over expressed E6-AP had higher expression levels of PI3K, Akt, and mTOR than control LNCaP cells; MTT assay showed that E6-AP-LNCaP cells were more responsive to the inhibitory effect of LY294002; Matrigel invasion chamber assay revealed increased cell crawling and adhesiveness of E6-AP-LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	ubiquitin protein ligase E3A	Homo sapiens	166-171
26261538-3	2015	RESULTS: Stably transfected LNCaP cells that over expressed E6-AP had higher expression levels of PI3K, Akt, and mTOR than control LNCaP cells; MTT assay showed that E6-AP-LNCaP cells were more responsive to the inhibitory effect of LY294002; Matrigel invasion chamber assay revealed increased cell crawling and adhesiveness of E6-AP-LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	ubiquitin protein ligase E3A	Homo sapiens	166-171
25770350-9	2015	In addition, the effect of RGC-32 on the cell cycle and IL-2 expression was inhibited by pretreatment of the samples with LY294002, indicating a role for phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	regulator of cell cycle	Mus musculus	27-33
25770350-9	2015	In addition, the effect of RGC-32 on the cell cycle and IL-2 expression was inhibited by pretreatment of the samples with LY294002, indicating a role for phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	interleukin 2	Mus musculus	56-60
25900365-9	2015	Incubation with the PI3K inhibitors LY294002 and wortmannin decreased IGFBP-2 mRNA and protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	insulin like growth factor binding protein 2	Homo sapiens	70-77
25614086-11	2015	Finally, LY294002, a phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, abolished the suppressive effect of TIP27 overexpression on PEPCK and G6Pase expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	135-140
25614086-11	2015	Finally, LY294002, a phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, abolished the suppressive effect of TIP27 overexpression on PEPCK and G6Pase expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	glucose-6-phosphatase, catalytic	Mus musculus	145-151
25640278-10	2015	The PI3K/Akt inhibitor LY294002 potentiated BMP9"s viability and migration suppression, and apoptosis induction, which was associated with reduced expression of snail and VEGF and increased expression of E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	9-12
26039236-7	2015	Nf1(+/-) MSPCs also showed hyperactivation of phosphoinositide 3-kinase (PI3-K) and mitogen activated protein kinase (MAPK) signaling pathways when compared to WT MSPCs, which were both significantly reduced in the presence of their pharmacologic inhibitors, LY294002 and PD0325901, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	259-267	neurofibromin 1	Homo sapiens	0-3
25640278-10	2015	The PI3K/Akt inhibitor LY294002 potentiated BMP9"s viability and migration suppression, and apoptosis induction, which was associated with reduced expression of snail and VEGF and increased expression of E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	growth differentiation factor 2	Homo sapiens	44-48
25640278-10	2015	The PI3K/Akt inhibitor LY294002 potentiated BMP9"s viability and migration suppression, and apoptosis induction, which was associated with reduced expression of snail and VEGF and increased expression of E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	vascular endothelial growth factor A	Homo sapiens	171-175
25817898-6	2015	SP600125, LY294002 and AG490 attenuated S100B-induced Steap4 protein expression or gene transcriptional activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	S100 protein, beta polypeptide, neural	Mus musculus	40-45
25640278-10	2015	The PI3K/Akt inhibitor LY294002 potentiated BMP9"s viability and migration suppression, and apoptosis induction, which was associated with reduced expression of snail and VEGF and increased expression of E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	cadherin 1	Homo sapiens	204-214
25817898-6	2015	SP600125, LY294002 and AG490 attenuated S100B-induced Steap4 protein expression or gene transcriptional activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	STEAP family member 4	Mus musculus	54-60
25997735-5	2015	We also showed that odorant stimulation activated Akt, and that Akt activation was completely blocked by incubation with both a PI3K inhibitor (LY294002) and Akt1 small interfering RNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	AKT serine/threonine kinase 1	Homo sapiens	50-53
25900077-6	2015	We show that phosphorylation of Akt and mTOR is required for OPC proliferation stimulated by growth factors (PDGF-AA and bFGF) or by CB1/CB2 agonists (ACEA/JWH133), since it was strongly decreased after LY294002 or rapamycin treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	AKT serine/threonine kinase 1	Homo sapiens	32-35
25900077-6	2015	We show that phosphorylation of Akt and mTOR is required for OPC proliferation stimulated by growth factors (PDGF-AA and bFGF) or by CB1/CB2 agonists (ACEA/JWH133), since it was strongly decreased after LY294002 or rapamycin treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	mechanistic target of rapamycin kinase	Homo sapiens	40-44
25650742-7	2015	Rottlerin, a protein kinase C (PKC)delta inhibitor and LY294002, a phosphatidylinositide 3-kinase (PI3K) inhibitor, reduced the PMA-mediated expression of MMP-9 and cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	67-97
25650742-7	2015	Rottlerin, a protein kinase C (PKC)delta inhibitor and LY294002, a phosphatidylinositide 3-kinase (PI3K) inhibitor, reduced the PMA-mediated expression of MMP-9 and cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	matrix metallopeptidase 9	Homo sapiens	155-160
25625935-11	2015	However, the alterations to the SDF-1alpha/CXCR4 cascade in the cells were abrogated following pretreatment with LY-294002, a phosphoinositide 3-kinase(PI3K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-122	C-X-C motif chemokine receptor 4	Rattus norvegicus	43-48
25997735-5	2015	We also showed that odorant stimulation activated Akt, and that Akt activation was completely blocked by incubation with both a PI3K inhibitor (LY294002) and Akt1 small interfering RNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	AKT serine/threonine kinase 1	Homo sapiens	64-67
25744447-8	2015	Furthermore, AKT activation was shown to play a critical role in regulating Bcl-2-mediated autophagy, as an AKT inhibitor (LY294002, AKTi) administered 30 min prior to ischemia significantly suppressed Bcl-2 phosphorylation and Bcl-2/Beclin1 complex dissociation, thereby reducing autophagy in RIC rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
25663277-9	2015	Increased Akt and ERK phosphorylation was observed in UTP-treated cultures, effect that was inhibited by SRC inhibitor 1 and PI3K blocker LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	AKT serine/threonine kinase 1	Homo sapiens	10-13
25663277-9	2015	Increased Akt and ERK phosphorylation was observed in UTP-treated cultures, effect that was inhibited by SRC inhibitor 1 and PI3K blocker LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	mitogen-activated protein kinase 1	Homo sapiens	18-21
25951933-7	2015	LY294002 and U0126 inhibited activation of p-PI-3K/Akt and p-Erk expression by Western blot and attenuated the expression of inflammation factors in BV2 cells by fluorescence staining.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	51-54
25951933-7	2015	LY294002 and U0126 inhibited activation of p-PI-3K/Akt and p-Erk expression by Western blot and attenuated the expression of inflammation factors in BV2 cells by fluorescence staining.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	59-64
25744447-8	2015	Furthermore, AKT activation was shown to play a critical role in regulating Bcl-2-mediated autophagy, as an AKT inhibitor (LY294002, AKTi) administered 30 min prior to ischemia significantly suppressed Bcl-2 phosphorylation and Bcl-2/Beclin1 complex dissociation, thereby reducing autophagy in RIC rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	beclin 1	Rattus norvegicus	234-241
25744447-8	2015	Furthermore, AKT activation was shown to play a critical role in regulating Bcl-2-mediated autophagy, as an AKT inhibitor (LY294002, AKTi) administered 30 min prior to ischemia significantly suppressed Bcl-2 phosphorylation and Bcl-2/Beclin1 complex dissociation, thereby reducing autophagy in RIC rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	BCL2, apoptosis regulator	Rattus norvegicus	76-81
25744447-8	2015	Furthermore, AKT activation was shown to play a critical role in regulating Bcl-2-mediated autophagy, as an AKT inhibitor (LY294002, AKTi) administered 30 min prior to ischemia significantly suppressed Bcl-2 phosphorylation and Bcl-2/Beclin1 complex dissociation, thereby reducing autophagy in RIC rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	AKT serine/threonine kinase 1	Rattus norvegicus	108-111
25744447-8	2015	Furthermore, AKT activation was shown to play a critical role in regulating Bcl-2-mediated autophagy, as an AKT inhibitor (LY294002, AKTi) administered 30 min prior to ischemia significantly suppressed Bcl-2 phosphorylation and Bcl-2/Beclin1 complex dissociation, thereby reducing autophagy in RIC rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	BCL2, apoptosis regulator	Rattus norvegicus	202-207
25964092-9	2015	In addition, ACh stimulated the activation of PI3K and AKT via EGFR activity, and blocking of PI3K/AKT pathway by special inhibitor LY294002 suppressed the ACh-mediated proliferation, invasion, and migration of NSCLC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	AKT serine/threonine kinase 1	Homo sapiens	55-58
25744447-8	2015	Furthermore, AKT activation was shown to play a critical role in regulating Bcl-2-mediated autophagy, as an AKT inhibitor (LY294002, AKTi) administered 30 min prior to ischemia significantly suppressed Bcl-2 phosphorylation and Bcl-2/Beclin1 complex dissociation, thereby reducing autophagy in RIC rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	BCL2, apoptosis regulator	Rattus norvegicus	202-207
25964092-9	2015	In addition, ACh stimulated the activation of PI3K and AKT via EGFR activity, and blocking of PI3K/AKT pathway by special inhibitor LY294002 suppressed the ACh-mediated proliferation, invasion, and migration of NSCLC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	AKT serine/threonine kinase 1	Homo sapiens	99-102
26021873-10	2015	These effects could be interrupted by the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	47-50
26000878-10	2015	Correspondingly, treatment with LY294002, a phosphatidylinositol-3-kinase inhibitor, mimicked PTEN overexpression effect in KYSE-150/RR cells, further suggesting a role for the Akt/GSK-3beta/Snail signaling in effects mediated through PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	phosphatase and tensin homolog	Homo sapiens	94-98
26146542-7	2015	In C2C12 myogenic cells, blocking the IGF1/PI3K/Akt pathway using LY294002 inhibitor reduced MSY3 phosphorylation levels resulting in its accumulation in the nuclei.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	insulin-like growth factor 1	Mus musculus	38-42
26146542-7	2015	In C2C12 myogenic cells, blocking the IGF1/PI3K/Akt pathway using LY294002 inhibitor reduced MSY3 phosphorylation levels resulting in its accumulation in the nuclei.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	thymoma viral proto-oncogene 1	Mus musculus	48-51
26146542-7	2015	In C2C12 myogenic cells, blocking the IGF1/PI3K/Akt pathway using LY294002 inhibitor reduced MSY3 phosphorylation levels resulting in its accumulation in the nuclei.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	Y box protein 3	Mus musculus	93-97
26020972-4	2015	AICAR increased phosphorylation of Akt, but the inhibition of PI3K/Akt activity using LY294002 did not affect the AICAR-induced changes in efferocytosis in macrophages.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	thymoma viral proto-oncogene 1	Mus musculus	67-70
26000878-10	2015	Correspondingly, treatment with LY294002, a phosphatidylinositol-3-kinase inhibitor, mimicked PTEN overexpression effect in KYSE-150/RR cells, further suggesting a role for the Akt/GSK-3beta/Snail signaling in effects mediated through PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	177-180
26000878-10	2015	Correspondingly, treatment with LY294002, a phosphatidylinositol-3-kinase inhibitor, mimicked PTEN overexpression effect in KYSE-150/RR cells, further suggesting a role for the Akt/GSK-3beta/Snail signaling in effects mediated through PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	glycogen synthase kinase 3 beta	Homo sapiens	181-190
26000878-10	2015	Correspondingly, treatment with LY294002, a phosphatidylinositol-3-kinase inhibitor, mimicked PTEN overexpression effect in KYSE-150/RR cells, further suggesting a role for the Akt/GSK-3beta/Snail signaling in effects mediated through PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	snail family transcriptional repressor 1	Homo sapiens	191-196
26000878-10	2015	Correspondingly, treatment with LY294002, a phosphatidylinositol-3-kinase inhibitor, mimicked PTEN overexpression effect in KYSE-150/RR cells, further suggesting a role for the Akt/GSK-3beta/Snail signaling in effects mediated through PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	phosphatase and tensin homolog	Homo sapiens	235-239
25943101-7	2015	The results also indicated that phosphatidylinositol 3-kinase(PI3K) inhibitors Ly294002 and GDC0941 effectively suppress AFPR mediated up-regulation expression of Src in AFPR positive HCC lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	163-166
25903737-7	2015	Pre-treatment with inhibitors of the pathway, LY294002 and rapamycin, decreased the expression of p-Akt and p70S6K and alleviated the morphological changes induced by IL-1beta in hippocampal neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	100-103
25903737-7	2015	Pre-treatment with inhibitors of the pathway, LY294002 and rapamycin, decreased the expression of p-Akt and p70S6K and alleviated the morphological changes induced by IL-1beta in hippocampal neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	ribosomal protein S6 kinase B1	Homo sapiens	108-114
25903737-7	2015	Pre-treatment with inhibitors of the pathway, LY294002 and rapamycin, decreased the expression of p-Akt and p70S6K and alleviated the morphological changes induced by IL-1beta in hippocampal neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	interleukin 1 beta	Homo sapiens	167-175
24372557-9	2015	Additionally, periostin overexpression increased the expression of survivin and the phosphorylation of Akt, which was reversed by pretreatment with the phosphatidylinositol 3-kinase (PI3K)-specific inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	periostin	Homo sapiens	14-23
25938237-9	2015	Furthermore, co-treatment with PI3K inhibitor LY294002 inhibited HYS-32-induced GSK3beta-pS9 and partially restored EB1 distribution from the microtubule lattice to plus ends.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	glycogen synthase kinase 3 beta	Rattus norvegicus	80-92
25938237-9	2015	Furthermore, co-treatment with PI3K inhibitor LY294002 inhibited HYS-32-induced GSK3beta-pS9 and partially restored EB1 distribution from the microtubule lattice to plus ends.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	microtubule-associated protein, RP/EB family, member 1	Rattus norvegicus	116-119
25576887-9	2015	An inhibitor of phosphoinositide 3-kinases (PI3K), LY294002 (0.2mg/mouse), abolished all observed effects of hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	16-42
24372557-9	2015	Additionally, periostin overexpression increased the expression of survivin and the phosphorylation of Akt, which was reversed by pretreatment with the phosphatidylinositol 3-kinase (PI3K)-specific inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	AKT serine/threonine kinase 1	Homo sapiens	103-106
25471227-8	2015	Furthermore, the protective effects of resveratrol were abolished by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
25738334-6	2015	The pharmacological inhibition of ERK (using U0126) or Akt (using LY294002) suppressed the 20GPPD-induced expression of HAS2, whereas treatment with an epidermal growth factor receptor (EGFR) inhibitor (AG1478) or an intracellular Ca2+ chelator (BAPTA/AM) did not exert any observable effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	55-58
25547390-8	2015	Blocking Akt activation using the selective inhibitor LY294002 partially reversed the CDPPB-induced protection against SO2-induced neurotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	thymoma viral proto-oncogene 1	Mus musculus	9-12
25749575-8	2015	Moreover, GB prevented cisplatin-induced reduction of Akt phosphorylation and LY294002, an inhibitor of PI3 K/Akt signaling, blocked the anti-apoptotic effect of GB in cisplatin-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	AKT serine/threonine kinase 1	Rattus norvegicus	110-113
25712031-7	2015	MMP-2 production and activity enhanced by 18% stretch were inhibited by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	matrix metallopeptidase 2	Homo sapiens	0-5
25712031-7	2015	MMP-2 production and activity enhanced by 18% stretch were inhibited by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	81-84
25738334-6	2015	The pharmacological inhibition of ERK (using U0126) or Akt (using LY294002) suppressed the 20GPPD-induced expression of HAS2, whereas treatment with an epidermal growth factor receptor (EGFR) inhibitor (AG1478) or an intracellular Ca2+ chelator (BAPTA/AM) did not exert any observable effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	hyaluronan synthase 2	Homo sapiens	120-124
25725259-5	2015	Both Akt1 and Akt2 phosphorylated the wild-type tomosyn, but not the mutant tomosyn in which Ser-783 was replaced with Ala. Phosphorylation of tomosyn at Ser-783 was also observed in the intact cells by insulin stimulation, which was blocked by PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	261-269	RAC-alpha serine/threonine-protein kinase	Cricetulus griseus	5-9
25725259-5	2015	Both Akt1 and Akt2 phosphorylated the wild-type tomosyn, but not the mutant tomosyn in which Ser-783 was replaced with Ala. Phosphorylation of tomosyn at Ser-783 was also observed in the intact cells by insulin stimulation, which was blocked by PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	261-269	RAC-beta serine/threonine-protein kinase	Cricetulus griseus	14-18
25776934-6	2015	These effects were prevented by treatment with EGFR inhibitor (AG1478) and phosphatidylinostol-3-kinase (PI3K) inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	75-103
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	mitogen-activated protein kinase 3	Homo sapiens	112-118
25748730-4	2015	Concanavalin A (ConA) at 20 mug/mL produced a 5.2-fold increase in IL-8 mRNA by 8h, and a 14.2-fold rise in IL-8 levels by 16 h. Inhibition of MEK (ERK kinase) and extracellular signal-regulated kinase (ERK) by PD98059 and U0126, or inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002 blocked both ConA-induced IL-8 mRNA expression and IL-8 secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	287-295	mitogen-activated protein kinase kinase 7	Homo sapiens	143-146
25748730-4	2015	Concanavalin A (ConA) at 20 mug/mL produced a 5.2-fold increase in IL-8 mRNA by 8h, and a 14.2-fold rise in IL-8 levels by 16 h. Inhibition of MEK (ERK kinase) and extracellular signal-regulated kinase (ERK) by PD98059 and U0126, or inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002 blocked both ConA-induced IL-8 mRNA expression and IL-8 secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	287-295	mitogen-activated protein kinase 1	Homo sapiens	148-151
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	131-134
26124933-4	2015	Therefore, we evaluated the effects of novel approaches including siRNA directed against BCRP and targeted therapy against PI3K/Akt signaling pathway using LY294002 (LY) to re-sensitize breast cancer MCF7 cell line to mitoxantrone (MTX) chemotherapy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	AKT serine/threonine kinase 1	Homo sapiens	128-131
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
25748730-6	2015	Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
25999679-8	2015	PTP1B signaling mechanism was determined by use of PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	0-5
25573060-1	2015	In the present study, it was demonstrated that the protein level of the apoptosis inhibitor Aven is regulated by the Akt signaling pathway, evidenced by the observation that Aven levels were significantly increased in MCF7 constitutively active (CA)-Akt cells and significantly inhibited following treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	313-321	apoptosis and caspase activation inhibitor	Homo sapiens	92-96
25573060-1	2015	In the present study, it was demonstrated that the protein level of the apoptosis inhibitor Aven is regulated by the Akt signaling pathway, evidenced by the observation that Aven levels were significantly increased in MCF7 constitutively active (CA)-Akt cells and significantly inhibited following treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	313-321	apoptosis and caspase activation inhibitor	Homo sapiens	174-178
25683371-7	2015	Moreover, small molecules embelin, LY294002 and resveratrol improved the cytotoxicity of ZD55-TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	94-99
25712622-5	2015	PI3K/AKT pathway was activated by MCD and triggered gene deregulation causing either activation or inhibition of all studied genes as demonstrated through cell incubation with the PI3K-inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	thymoma viral proto-oncogene 1	Mus musculus	5-8
25999679-15	2015	Pretreatment with PD98059 and LY294002 abolished TCS-401-induced activation of Erk, Akt, cell proliferation, and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	Eph receptor B1	Rattus norvegicus	79-82
25999679-15	2015	Pretreatment with PD98059 and LY294002 abolished TCS-401-induced activation of Erk, Akt, cell proliferation, and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Rattus norvegicus	84-87
25871290-8	2015	Additionally, ATX administration increased Akt and Bad phosphorylation and further down-regulated the expression of other downstream pro-apoptotic proteins (cytochrome c and caspase-3/9); these effects were reversed by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	238-246	caspase 3	Rattus norvegicus	174-185
25724180-9	2015	Akt inhibitor LY294002 reversed the role of TRIM24 on chemoresistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	0-3
25724180-9	2015	Akt inhibitor LY294002 reversed the role of TRIM24 on chemoresistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	tripartite motif containing 24	Homo sapiens	44-50
25913171-13	2015	P-eNOS and P-Akt expression can be unregulated by RNH-6270 treatment and blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Homo sapiens	13-16
25807175-3	2015	In the present study, we focused on the mechanism of its neurotrophic effect; the results showed that MDHB-induced upregulation of neuronal survival and neurite outgrowth in cultured primary cortical neurons could be blocked by the adenosine A2a receptor inhibitor (ZM241385) and the phosphoinositide 3-kinase (PI3K) inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	328-336	adenosine A2a receptor	Rattus norvegicus	232-254
26062301-0	2015	The synergistic killing of AML cells co-cultured with HS-5 bone marrow stromal cells by As2O3 and the PI3K/Akt signaling pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Homo sapiens	107-110
26062301-1	2015	We aimed to investigate whether a combination of resistance to arsenic trioxide (As2O3) and the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway inhibitor LY294002 can inhibit the proliferation of AML cells in the bone marrow microenvironment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	96-121
26062301-1	2015	We aimed to investigate whether a combination of resistance to arsenic trioxide (As2O3) and the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway inhibitor LY294002 can inhibit the proliferation of AML cells in the bone marrow microenvironment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	AKT serine/threonine kinase 1	Homo sapiens	129-132
26062301-4	2015	The PI3K/Akt signaling pathway was detected by Western Blot in co-cultured AML cells cultured alone or treated with As2O3 alone or in combination with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	AKT serine/threonine kinase 1	Homo sapiens	9-12
25784556-8	2015	A direct correlation between Ser(P)(473)-AKT and Ser(P)(401)-GATA2 was evident, and inhibition of AKT phosphorylation by the PI3K inhibitor LY294002 blocked Ser(401)-GATA2 phosphorylation and the increase in GRB10 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	AKT serine/threonine kinase 1	Homo sapiens	41-44
25784556-8	2015	A direct correlation between Ser(P)(473)-AKT and Ser(P)(401)-GATA2 was evident, and inhibition of AKT phosphorylation by the PI3K inhibitor LY294002 blocked Ser(401)-GATA2 phosphorylation and the increase in GRB10 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	GATA binding protein 2	Homo sapiens	61-66
25784556-8	2015	A direct correlation between Ser(P)(473)-AKT and Ser(P)(401)-GATA2 was evident, and inhibition of AKT phosphorylation by the PI3K inhibitor LY294002 blocked Ser(401)-GATA2 phosphorylation and the increase in GRB10 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	AKT serine/threonine kinase 1	Homo sapiens	98-101
25784556-8	2015	A direct correlation between Ser(P)(473)-AKT and Ser(P)(401)-GATA2 was evident, and inhibition of AKT phosphorylation by the PI3K inhibitor LY294002 blocked Ser(401)-GATA2 phosphorylation and the increase in GRB10 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	GATA binding protein 2	Homo sapiens	166-171
25784556-8	2015	A direct correlation between Ser(P)(473)-AKT and Ser(P)(401)-GATA2 was evident, and inhibition of AKT phosphorylation by the PI3K inhibitor LY294002 blocked Ser(401)-GATA2 phosphorylation and the increase in GRB10 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	growth factor receptor bound protein 10	Homo sapiens	208-213
25945059-3	2015	Here, we sought to investigate the regulation of the Hh pathway transcription factor Gli1 by arsenic trioxide and phosphoinositide 3-kinase (PI3K) inhibitor LY294002 in colon carcinoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	GLI family zinc finger 1	Homo sapiens	85-89
25945059-7	2015	To elucidate the regulation of Gli1 expression, we found that both Gli inhibitor arsenic trioxide and PI3K inhibitor LY294002 significantly reduced Gli1 protein expression and colon carcinoma cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	GLI family zinc finger 1	Homo sapiens	31-35
25945059-7	2015	To elucidate the regulation of Gli1 expression, we found that both Gli inhibitor arsenic trioxide and PI3K inhibitor LY294002 significantly reduced Gli1 protein expression and colon carcinoma cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	GLI family zinc finger 1	Homo sapiens	31-34
25945059-7	2015	To elucidate the regulation of Gli1 expression, we found that both Gli inhibitor arsenic trioxide and PI3K inhibitor LY294002 significantly reduced Gli1 protein expression and colon carcinoma cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	GLI family zinc finger 1	Homo sapiens	148-152
25945059-9	2015	More importantly, the inhibition of Hedgehog-Gli1 by arsenic trioxide showed synergistic anticancer effect with the PI3K inhibitor LY294002 in colon carcinoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	GLI family zinc finger 1	Homo sapiens	45-49
25960232-6	2015	Pre-treatment of PI3K inhibitor LY294002 enhanced curcumin-induced cell death, apoptosis, and autophagy via modulating the expression of Bcl-2 family members and autophagosome formation in MCF-7 breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	BCL2 apoptosis regulator	Homo sapiens	137-142
25875646-12	2015	LY294002 could block the PI3K/Akt signaling pathway and rescue the promotion caused by suppressing miR-223 in mast cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	30-33
25875646-12	2015	LY294002 could block the PI3K/Akt signaling pathway and rescue the promotion caused by suppressing miR-223 in mast cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	microRNA 223	Homo sapiens	99-106
25832422-10	2015	Furthermore, treatment with Rd dose-dependently increased the phosphorylation of Akt and ERK, and significantly decreased PC12 cell apoptosis, which were blocked by co-application of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	AKT serine/threonine kinase 1	Rattus norvegicus	81-84
25832422-10	2015	Furthermore, treatment with Rd dose-dependently increased the phosphorylation of Akt and ERK, and significantly decreased PC12 cell apoptosis, which were blocked by co-application of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	Eph receptor B1	Rattus norvegicus	89-92
25338292-5	2015	LY294002 or (and) PD98059 were injected intracerebroventricularly to selectively inhibit the activation of PI3K/Akt or ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	112-115
25672876-9	2015	Moreover, we found that the growth inhibitory effects of resveratrol were enhanced by treatment with LY294002 [a phosphatidylinositol 3-kinase (PI3-K) inhibitor] more so than by treatment with PD98059 (a MEK inhibitor), which indicates that resveratrol exerts its inhibitory effects on sebocyte proliferation through the inhibition of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	113-142
25672876-9	2015	Moreover, we found that the growth inhibitory effects of resveratrol were enhanced by treatment with LY294002 [a phosphatidylinositol 3-kinase (PI3-K) inhibitor] more so than by treatment with PD98059 (a MEK inhibitor), which indicates that resveratrol exerts its inhibitory effects on sebocyte proliferation through the inhibition of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	mitogen-activated protein kinase kinase 7	Homo sapiens	204-207
25672876-9	2015	Moreover, we found that the growth inhibitory effects of resveratrol were enhanced by treatment with LY294002 [a phosphatidylinositol 3-kinase (PI3-K) inhibitor] more so than by treatment with PD98059 (a MEK inhibitor), which indicates that resveratrol exerts its inhibitory effects on sebocyte proliferation through the inhibition of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Homo sapiens	335-338
25201632-9	2015	In addition, LY294002, a phosphatidylinositol-3-kinase (PI3K) inhibitor, displayed the similar trends as AG1478, suggesting that PI3K/Akt signaling may be the downstream of EGFR in ACh-elicited anti-apoptotic property.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	25-54
25201632-9	2015	In addition, LY294002, a phosphatidylinositol-3-kinase (PI3K) inhibitor, displayed the similar trends as AG1478, suggesting that PI3K/Akt signaling may be the downstream of EGFR in ACh-elicited anti-apoptotic property.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	134-137
25201632-9	2015	In addition, LY294002, a phosphatidylinositol-3-kinase (PI3K) inhibitor, displayed the similar trends as AG1478, suggesting that PI3K/Akt signaling may be the downstream of EGFR in ACh-elicited anti-apoptotic property.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	epidermal growth factor receptor	Rattus norvegicus	173-177
25338292-5	2015	LY294002 or (and) PD98059 were injected intracerebroventricularly to selectively inhibit the activation of PI3K/Akt or ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen activated protein kinase 3	Rattus norvegicus	119-125
25338292-11	2015	IPC2 x 5 min significantly reduces cerebral infarct volume, neurological deficit scores, and MPO activity; all of which were diminished by LY294002 or (and) PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	myeloperoxidase	Rattus norvegicus	93-96
25338292-12	2015	IPC2 x 5 min significantly upregulates the expressions of p-Akt and p-ERK1/2, which were inhibited by LY294002 or (and) PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
25338292-12	2015	IPC2 x 5 min significantly upregulates the expressions of p-Akt and p-ERK1/2, which were inhibited by LY294002 or (and) PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	mitogen activated protein kinase 3	Rattus norvegicus	70-76
25338292-13	2015	IPC2 x 5 min significantly downregulates the expressions of NF-kappaB p65 and COX-2 and attenuates the release of TNF-alpha; all of which were abolished by LY294002 or (and) PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	synaptotagmin 1	Rattus norvegicus	70-73
25338292-13	2015	IPC2 x 5 min significantly downregulates the expressions of NF-kappaB p65 and COX-2 and attenuates the release of TNF-alpha; all of which were abolished by LY294002 or (and) PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	78-83
25338292-13	2015	IPC2 x 5 min significantly downregulates the expressions of NF-kappaB p65 and COX-2 and attenuates the release of TNF-alpha; all of which were abolished by LY294002 or (and) PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	tumor necrosis factor	Rattus norvegicus	114-123
25734900-12	2015	S1P-induced c-Jun activation was reduced by PP1, AG1478, AG1296, U0126, SP600125, SB202190, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	12-17
26101705-6	2015	Interestingly, LY294002, a special inhibitor to PI3K/AKT signaling which was determined as a downstream pathway of netrin-1, restored the reduction in BVES caused by netrin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	53-56
26101705-6	2015	Interestingly, LY294002, a special inhibitor to PI3K/AKT signaling which was determined as a downstream pathway of netrin-1, restored the reduction in BVES caused by netrin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	netrin 1	Homo sapiens	115-123
26101705-6	2015	Interestingly, LY294002, a special inhibitor to PI3K/AKT signaling which was determined as a downstream pathway of netrin-1, restored the reduction in BVES caused by netrin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	blood vessel epicardial substance	Homo sapiens	151-155
26101705-6	2015	Interestingly, LY294002, a special inhibitor to PI3K/AKT signaling which was determined as a downstream pathway of netrin-1, restored the reduction in BVES caused by netrin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	netrin 1	Homo sapiens	166-174
25498712-5	2015	Additionally, pretreatment with the PI3K inhibitor (LY294002) completely abolished the protective effects of PS-WNP against Abeta(25-35)-induced neuronal cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	amyloid beta precursor protein	Rattus norvegicus	124-129
25885904-6	2015	These changes were reversed with the treatment of a PI3K/Akt inhibitor LY294002 in vivo or in cells transfected with Akt dominant-negative (Akt-DN) plasmids in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	thymoma viral proto-oncogene 1	Mus musculus	57-60
24777577-5	2015	By contrast, The PI3K/Akt inhibitor LY294002 inhibited phosphorylation of Akt and differentiation of NSCs in the SGZ and SVZ, resulting in no change in the proliferation of NSCs and ERK1/2 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	thymoma viral proto-oncogene 1	Mus musculus	22-25
24777577-5	2015	By contrast, The PI3K/Akt inhibitor LY294002 inhibited phosphorylation of Akt and differentiation of NSCs in the SGZ and SVZ, resulting in no change in the proliferation of NSCs and ERK1/2 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	thymoma viral proto-oncogene 1	Mus musculus	74-77
25581901-6	2015	EGCG-induced NO production was diminished by pretreatment with LY294002 (an Akt inhibitor), KN62 (a CaMKII inhibitor), and compound C (an AMPK inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	AKT serine/threonine kinase 1	Homo sapiens	76-79
25387407-5	2015	PI3K inhibitor LY294002 activated FOXO1A and induced formation of CD31(+) hESC-EC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	forkhead box O1	Homo sapiens	34-40
25387407-5	2015	PI3K inhibitor LY294002 activated FOXO1A and induced formation of CD31(+) hESC-EC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	platelet and endothelial cell adhesion molecule 1	Homo sapiens	66-70
25693787-3	2015	Among these compounds, compound 25 exhibited the most potent and selective activity for PI3Kalpha, with the IC50 value of 0.016muM, an approximately 30-fold increase in comparison with LY294002, it also has an increased potency of approximately 11-fold for PI3Kbeta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	88-97
25680461-9	2015	LY294002 and MK-2206, two established Akt inhibitors, alleviated K6PC-5- or S1P-mediated osteoblast protection against Dex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	38-41
25680461-9	2015	LY294002 and MK-2206, two established Akt inhibitors, alleviated K6PC-5- or S1P-mediated osteoblast protection against Dex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	76-79
25620135-11	2015	LY294002 (10muM), a PI3K/Akt pathway inhibitor, significantly inhibited the endostatin-induced proliferation and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	25-28
25555372-5	2015	Furthermore, the intrathecal administration of an anti-MCP-1 neutralizing antibody or PI3K inhibitor LY294002 reduced the expression of p-Akt or OX-42, and LY294002 attenuated the mechanical allodynia of BCP rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Rattus norvegicus	138-141
25555372-5	2015	Furthermore, the intrathecal administration of an anti-MCP-1 neutralizing antibody or PI3K inhibitor LY294002 reduced the expression of p-Akt or OX-42, and LY294002 attenuated the mechanical allodynia of BCP rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	C-C motif chemokine ligand 2	Rattus norvegicus	55-60
25931349-10	2015	Of the studied compounds, a combination of RX + LY294002 induced the greatest cytotoxicity in both SET-2 and HEL cell lines, and rapamycin the least.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	99-104
25630653-9	2015	The Akt inhibitor, LY294002, inhibited the effect of atorvastatin on inducing Akt phosphorylation and on suppressing H2O2-mediated caspase up-regulation and cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	4-7
25630653-9	2015	The Akt inhibitor, LY294002, inhibited the effect of atorvastatin on inducing Akt phosphorylation and on suppressing H2O2-mediated caspase up-regulation and cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	78-81
25578563-8	2015	Furthermore, the PI3K inhibitors LY294002, BKM120 and MEK inhibitors U0126, PD0325901 blocked the enhanced S6K1 activity induced by Kb.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	ribosomal protein S6 kinase B1	Homo sapiens	107-111
25308861-5	2015	After Protein Kinase B (PKB/Akt) signal pathway was inhibited by the p-Akt inhibitor (LY294002) and the expression of MRP1 was restrained by siRNA of MRP1, CCK-8 was used to examine the cell proliferation after treatment with cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	protein tyrosine kinase 2 beta	Homo sapiens	6-22
25308861-5	2015	After Protein Kinase B (PKB/Akt) signal pathway was inhibited by the p-Akt inhibitor (LY294002) and the expression of MRP1 was restrained by siRNA of MRP1, CCK-8 was used to examine the cell proliferation after treatment with cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	AKT serine/threonine kinase 1	Homo sapiens	24-31
25533999-6	2015	Inhibition of these PI3K/Akt and ERK1/2 pathways by specific inhibitors, LY294002 and PD98059, partially reduces the protective effect of bFGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Rattus norvegicus	25-28
26045735-6	2015	In addition, LY294002 (a PI3K inhibitor), sc-221226 (an Akt inhibitor), and L-NAME (an NOS inhibitor) abolished Ad-SIRT1-induced migration and proliferation of EPCs, and prevented nitric oxide (NO) production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	sirtuin 1	Mus musculus	115-120
26045735-7	2015	Phosphorylation of Akt, PI3K, and endothelial nitricoxide synthase (eNOS) were up-regulated by Ad-SIRT1, which was attenuated by LY294002, sc-221226, and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	thymoma viral proto-oncogene 1	Mus musculus	19-22
26045735-7	2015	Phosphorylation of Akt, PI3K, and endothelial nitricoxide synthase (eNOS) were up-regulated by Ad-SIRT1, which was attenuated by LY294002, sc-221226, and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	nitric oxide synthase 3, endothelial cell	Mus musculus	34-66
26045735-7	2015	Phosphorylation of Akt, PI3K, and endothelial nitricoxide synthase (eNOS) were up-regulated by Ad-SIRT1, which was attenuated by LY294002, sc-221226, and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	nitric oxide synthase 3, endothelial cell	Mus musculus	68-72
26045735-7	2015	Phosphorylation of Akt, PI3K, and endothelial nitricoxide synthase (eNOS) were up-regulated by Ad-SIRT1, which was attenuated by LY294002, sc-221226, and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	sirtuin 1	Mus musculus	95-103
26045756-8	2015	The ERK1/2 inhibitor U0126 and the Akt inhibitor LY294002 also inhibited hypoxia-induced HIF-1alpha and VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	35-38
26045756-8	2015	The ERK1/2 inhibitor U0126 and the Akt inhibitor LY294002 also inhibited hypoxia-induced HIF-1alpha and VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	vascular endothelial growth factor A	Homo sapiens	104-108
25572822-6	2015	We demonstrated that chloroquine (CQ) and 2-(4-morpholinyl)-8-phenylchromone (LY294002) could effectively reduce TRAIL-refractory breast cancer cell viability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	TNF superfamily member 10	Homo sapiens	113-118
25533999-6	2015	Inhibition of these PI3K/Akt and ERK1/2 pathways by specific inhibitors, LY294002 and PD98059, partially reduces the protective effect of bFGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	mitogen activated protein kinase 3	Rattus norvegicus	33-39
25533999-6	2015	Inhibition of these PI3K/Akt and ERK1/2 pathways by specific inhibitors, LY294002 and PD98059, partially reduces the protective effect of bFGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	fibroblast growth factor 2	Rattus norvegicus	138-142
25394413-8	2015	Additionally, treatment with LY294002 (10 microM), a specific inhibitor of phosphatidylinositol 3-kinase/Akt signaling, eliminated the omentin-induced increase in neurosphere size and cell viability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	thymoma viral proto-oncogene 1	Mus musculus	105-108
25638063-8	2015	Blocking the activation of Akt and Erk with their potent inhibitors LY294002 and PD98059, respectively, markedly attenuated the octacosanol-induced proliferation and migration of HUVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	27-30
25638063-8	2015	Blocking the activation of Akt and Erk with their potent inhibitors LY294002 and PD98059, respectively, markedly attenuated the octacosanol-induced proliferation and migration of HUVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	mitogen-activated protein kinase 1	Homo sapiens	35-38
25378227-9	2015	In addition, the phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 abrogated the enhancing effects of TWIST on mRNA levels of c-Myc and c-Jun, soluble beta-catenin levels, MMP-2 expression, cell invasion and GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	twist family bHLH transcription factor 1	Homo sapiens	109-114
25378227-9	2015	In addition, the phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 abrogated the enhancing effects of TWIST on mRNA levels of c-Myc and c-Jun, soluble beta-catenin levels, MMP-2 expression, cell invasion and GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	133-138
25378227-9	2015	In addition, the phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 abrogated the enhancing effects of TWIST on mRNA levels of c-Myc and c-Jun, soluble beta-catenin levels, MMP-2 expression, cell invasion and GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-148
25378227-9	2015	In addition, the phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 abrogated the enhancing effects of TWIST on mRNA levels of c-Myc and c-Jun, soluble beta-catenin levels, MMP-2 expression, cell invasion and GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	catenin beta 1	Homo sapiens	158-170
25938832-7	2015	Moreover, Pretreatment with LY294002 inhibited the palmitate sodium induced-phosphorylation of PI3K and Akt, and promoted upregulation of CHOP and Bax induced by palmitate sodium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	104-107
25378227-9	2015	In addition, the phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 abrogated the enhancing effects of TWIST on mRNA levels of c-Myc and c-Jun, soluble beta-catenin levels, MMP-2 expression, cell invasion and GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	matrix metallopeptidase 2	Homo sapiens	179-184
25378227-9	2015	In addition, the phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 abrogated the enhancing effects of TWIST on mRNA levels of c-Myc and c-Jun, soluble beta-catenin levels, MMP-2 expression, cell invasion and GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	glycogen synthase kinase 3 beta	Homo sapiens	215-224
25908029-9	2015	The PI3K/Akt inhibitor LY294002 completely blocked BDE-99-induced Snail and invasion of HCT-116 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	9-12
25908029-9	2015	The PI3K/Akt inhibitor LY294002 completely blocked BDE-99-induced Snail and invasion of HCT-116 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	homeobox D13	Homo sapiens	51-54
25908029-9	2015	The PI3K/Akt inhibitor LY294002 completely blocked BDE-99-induced Snail and invasion of HCT-116 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	snail family transcriptional repressor 1	Homo sapiens	66-71
25738356-5	2015	Moreover, blocking autophagy using pharmacological inhibitors LY294002, chloroquine (CQ) and quinacrine (QN) enhanced asparaginase-induced cell death and apoptosis, indicating the cytoprotective role of autophagy in asparaginase-treated K562 and KU812 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	asparaginase	Homo sapiens	118-130
25938832-7	2015	Moreover, Pretreatment with LY294002 inhibited the palmitate sodium induced-phosphorylation of PI3K and Akt, and promoted upregulation of CHOP and Bax induced by palmitate sodium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	DNA damage inducible transcript 3	Homo sapiens	138-142
25938832-7	2015	Moreover, Pretreatment with LY294002 inhibited the palmitate sodium induced-phosphorylation of PI3K and Akt, and promoted upregulation of CHOP and Bax induced by palmitate sodium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	BCL2 associated X, apoptosis regulator	Homo sapiens	147-150
25689721-8	2015	Ursolic acid and LY294002 inhibited HG-induced mesangial cell hypertrophy and proliferation, down-regulated p85PI3K, pAkt, pmTOR, p62/SQSTMI, and collagen I expression and up-regulated LC3II expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	130-133
25643147-6	2015	In parallel, the phosphorylation level of Akt kinase was markedly increased by the oil treatment, which was partially attenuated by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	AKT serine/threonine kinase 1	Homo sapiens	42-45
24531716-9	2015	Blocking the PI3K/Akt pathway by its specific inhibitor LY294002 or by Akt small interfering RNA resulted in the reduced chemosensitivity of HL60/ADR cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	18-21
25643147-6	2015	In parallel, the phosphorylation level of Akt kinase was markedly increased by the oil treatment, which was partially attenuated by PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	AKT serine/threonine kinase 1	Homo sapiens	137-140
24840719-11	2015	Chemerin can increase eNOS and Akt levels in HUVECs, and these results could be partly blocked by LY294002 and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	retinoic acid receptor responder 2	Homo sapiens	0-8
25488290-0	2015	Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junin virus infection in Vero cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	23-26
25488290-4	2015	Treatment of infected cultures with Ly294002, an inhibitor of the PI3K/Akt pathway, produced an apoptotic response similar to that observed for uninfected cells treated with the drug.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	71-74
25661377-9	2015	In addition, the AKR1C3 mediated DOX resistance can be conquered by the Akt inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	aldo-keto reductase family 1 member C3	Homo sapiens	17-23
25661377-9	2015	In addition, the AKR1C3 mediated DOX resistance can be conquered by the Akt inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	72-75
24840719-11	2015	Chemerin can increase eNOS and Akt levels in HUVECs, and these results could be partly blocked by LY294002 and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	nitric oxide synthase 3	Homo sapiens	22-26
25158146-6	2015	Our results show that Sendai virus infection, which is recognized by RIG-I, led to IRF3 activation and IFN-beta expression and these responses were attenuated by the PI3K inhibitor (LY294002) and an Akt dominant-negative mutant in the macrophage cell line(RAW264.7).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	DExD/H-box helicase 58	Homo sapiens	69-74
24840719-12	2015	Chemerin significantly decreased TNF-alpha-induced NF-kappaB and VCAM-1 in HUVECs, and these changes were partly inhibited by LY294002 and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	retinoic acid receptor responder 2	Homo sapiens	0-8
24840719-12	2015	Chemerin significantly decreased TNF-alpha-induced NF-kappaB and VCAM-1 in HUVECs, and these changes were partly inhibited by LY294002 and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	tumor necrosis factor	Homo sapiens	33-42
24840719-12	2015	Chemerin significantly decreased TNF-alpha-induced NF-kappaB and VCAM-1 in HUVECs, and these changes were partly inhibited by LY294002 and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	vascular cell adhesion molecule 1	Homo sapiens	65-71
25372512-10	2015	When osteoblasts transfected with pEGFP-N1-IRS1 were exposed to a PI3K inhibitor (LY294002), the effects of IRS1 overexpression were reversed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	insulin receptor substrate 1	Homo sapiens	34-47
25372512-10	2015	When osteoblasts transfected with pEGFP-N1-IRS1 were exposed to a PI3K inhibitor (LY294002), the effects of IRS1 overexpression were reversed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	insulin receptor substrate 1	Homo sapiens	43-47
25432925-13	2015	IGF1 treatment resulted in distinct apical fibronectin staining on blastocysts, which was reduced by the PI3 kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	insulin like growth factor 1	Homo sapiens	0-4
25432925-13	2015	IGF1 treatment resulted in distinct apical fibronectin staining on blastocysts, which was reduced by the PI3 kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	fibronectin 1	Homo sapiens	43-54
25432925-14	2015	This coincided with a significant increase in blastocyst outgrowth in the presence of IGF1 (P &lt; 0.01) or fibronectin (P &lt; 0.001), which was abolished by LY294002 (P &lt; 0.001).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	insulin like growth factor 1	Homo sapiens	86-90
25158146-6	2015	Our results show that Sendai virus infection, which is recognized by RIG-I, led to IRF3 activation and IFN-beta expression and these responses were attenuated by the PI3K inhibitor (LY294002) and an Akt dominant-negative mutant in the macrophage cell line(RAW264.7).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	interferon regulatory factor 3	Homo sapiens	83-87
25432925-14	2015	This coincided with a significant increase in blastocyst outgrowth in the presence of IGF1 (P &lt; 0.01) or fibronectin (P &lt; 0.001), which was abolished by LY294002 (P &lt; 0.001).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	fibronectin 1	Homo sapiens	108-119
25158146-6	2015	Our results show that Sendai virus infection, which is recognized by RIG-I, led to IRF3 activation and IFN-beta expression and these responses were attenuated by the PI3K inhibitor (LY294002) and an Akt dominant-negative mutant in the macrophage cell line(RAW264.7).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	interferon beta 1	Homo sapiens	103-111
25621554-6	2015	Furthermore, these effects were significantly inhibited by PI3K/Akt inhibitor LY294002 at a glucose concentration of 15.5 mM, which was the optimum.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	thymoma viral proto-oncogene 1	Mus musculus	64-67
25158146-7	2015	IRF3 phosphorylation and dimerization as well as IFN-beta expression induced by a synthetic RIG-I agonist, short poly(I:C), were suppressed by LY294002 or siRNA-Akt in bone marrow-derived macrophages.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	interferon regulatory factor 3	Homo sapiens	0-4
25158146-7	2015	IRF3 phosphorylation and dimerization as well as IFN-beta expression induced by a synthetic RIG-I agonist, short poly(I:C), were suppressed by LY294002 or siRNA-Akt in bone marrow-derived macrophages.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	interferon beta 1	Homo sapiens	49-57
25158146-7	2015	IRF3 phosphorylation and dimerization as well as IFN-beta expression induced by a synthetic RIG-I agonist, short poly(I:C), were suppressed by LY294002 or siRNA-Akt in bone marrow-derived macrophages.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	DExD/H-box helicase 58	Homo sapiens	92-97
25855199-6	2015	Targeting the PI3K/Akt pathway by its specific inhibitor LY294002, or by Akt RNA interfering reversed the MDR phenotype of K562/ADR cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	19-22
25569743-10	2015	Treatment of cells with specific inhibitors (PD98059/LY294002/rapamycin) of growth signaling pathways (MEK/PI3K/mTOR) demonstrated that in HCEC-1CT, PAK1 expression is regulated by MEK, PI3K, and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	p21 (RAC1) activated kinase 1	Homo sapiens	149-153
25467375-5	2015	We found that Genistein (PTK inhibitor) could inhibit protein kinase C (PKC), phosphatidylinositol-3 kinase (PI3K)/protein kinase B (Akt or PKB) MAPK signaling pathway with different degrees, LY294002 (PI3K inhibitor) could not only inhibit phospho-PI3K/Akt expression, but also inhibit p38 and c-Jun NH2-terminal kinases (JNK) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	192-200	AKT serine/threonine kinase 1	Rattus norvegicus	133-136
25638174-14	2015	Blocking Akt and/or ERK with the PI3K inhibitor, LY294002, or the ERK inhibitor, PD98059, induced down-regulation of MMP9 and up-regulation of cleaved caspase-3 and PARP-1, resembling the effects of luteolin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	9-12
25638174-14	2015	Blocking Akt and/or ERK with the PI3K inhibitor, LY294002, or the ERK inhibitor, PD98059, induced down-regulation of MMP9 and up-regulation of cleaved caspase-3 and PARP-1, resembling the effects of luteolin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mitogen-activated protein kinase 1	Homo sapiens	20-23
25638174-14	2015	Blocking Akt and/or ERK with the PI3K inhibitor, LY294002, or the ERK inhibitor, PD98059, induced down-regulation of MMP9 and up-regulation of cleaved caspase-3 and PARP-1, resembling the effects of luteolin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	matrix metallopeptidase 9	Homo sapiens	117-121
25638174-14	2015	Blocking Akt and/or ERK with the PI3K inhibitor, LY294002, or the ERK inhibitor, PD98059, induced down-regulation of MMP9 and up-regulation of cleaved caspase-3 and PARP-1, resembling the effects of luteolin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	caspase 3	Homo sapiens	151-160
25638174-14	2015	Blocking Akt and/or ERK with the PI3K inhibitor, LY294002, or the ERK inhibitor, PD98059, induced down-regulation of MMP9 and up-regulation of cleaved caspase-3 and PARP-1, resembling the effects of luteolin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	poly(ADP-ribose) polymerase 1	Homo sapiens	165-171
25556164-9	2015	Furthermore, Slug signaling modulated E- to N-cadherin switch, which was influenced by the kinase inhibitor PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	snail family transcriptional repressor 2	Homo sapiens	13-17
25556164-9	2015	Furthermore, Slug signaling modulated E- to N-cadherin switch, which was influenced by the kinase inhibitor PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	cadherin 2	Homo sapiens	44-54
25373458-6	2015	The phosphorylation of HSP27 induced by HG was blocked by the specific phosphoinositide 3-kinase (PI3K) inhibitor LY294002 and the specific extracellular signal-regulated kinase (ERK) 1/2 inhibitor U0126 in a concentration-dependent manner, with peak inhibition rates of 62.6 and 56.1%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	heat shock protein family B (small) member 1	Homo sapiens	23-28
25373458-6	2015	The phosphorylation of HSP27 induced by HG was blocked by the specific phosphoinositide 3-kinase (PI3K) inhibitor LY294002 and the specific extracellular signal-regulated kinase (ERK) 1/2 inhibitor U0126 in a concentration-dependent manner, with peak inhibition rates of 62.6 and 56.1%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	71-96
24962218-5	2015	The role of the PI3 kinase-AKT signalling and splicing regulatory protein SRp40 in the production of EDA+Fn was studied by using the chemical inhibitor LY294002 and siRNA targeted to SRp40 respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	ectodysplasin A	Homo sapiens	101-104
25048007-4	2015	LY294002, the PI3K inhibitor, blocked the protection as well as the up-regulation of Akt phosphorylation of BBR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	85-88
25355053-9	2015	Notably, treatment with the PI3K inhibitor, LY294002, decreased the levels of phosphorylated (p)-PI3K, p-Akt and p-mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	105-108
25355053-9	2015	Notably, treatment with the PI3K inhibitor, LY294002, decreased the levels of phosphorylated (p)-PI3K, p-Akt and p-mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	mechanistic target of rapamycin kinase	Homo sapiens	115-119
25476740-8	2015	In addition, inhibition of PI3K/AKT pathway by specific inhibitor LY294002 suppressed the CXCL13-mediated growth, migration, and invasion of colon cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	32-35
25476740-8	2015	In addition, inhibition of PI3K/AKT pathway by specific inhibitor LY294002 suppressed the CXCL13-mediated growth, migration, and invasion of colon cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	C-X-C motif chemokine ligand 13	Homo sapiens	90-96
25516570-8	2015	In contrast, treatment with LY294002, which impairs the PI3K activity, did not exert such an inhibitory effect on the sequestration of GFP-CESA3, but caused a predominant accumulation of GFP-CESA3 at the ring-shaped periphery of the Golgi apparatus, resulting in the removal of GFP-CESA3 from the PM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	Cellulose synthase family protein	Arabidopsis thaliana	191-196
25516570-8	2015	In contrast, treatment with LY294002, which impairs the PI3K activity, did not exert such an inhibitory effect on the sequestration of GFP-CESA3, but caused a predominant accumulation of GFP-CESA3 at the ring-shaped periphery of the Golgi apparatus, resulting in the removal of GFP-CESA3 from the PM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	Cellulose synthase family protein	Arabidopsis thaliana	191-196
25652862-8	2015	Leptin promoted the expression of p-AKT in HFL-1, and this effect was blocked by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	leptin	Homo sapiens	0-6
25652862-8	2015	Leptin promoted the expression of p-AKT in HFL-1, and this effect was blocked by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	AKT serine/threonine kinase 1	Homo sapiens	36-39
25652862-8	2015	Leptin promoted the expression of p-AKT in HFL-1, and this effect was blocked by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	complement factor H related 1	Homo sapiens	43-48
24975165-7	2015	LY294002 and IC87114 prevented Akt phosphorylation as expected and down-regulated the expression of inflammatory factors IL-6, MCP-1,TNFalpha and iNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	31-34
24469053-7	2015	The pan-PI3K inhibitor LY294002 and small interfering RNA targeting PIK3CA both abrogate the growth-promoting effect of TRIM24.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	tripartite motif containing 24	Homo sapiens	120-126
25310956-5	2015	The involvement of these signaling systems in the mechanism of the nucleoside action was strengthened by a reduction of the protective effect when glial cells were pretreated with U0126 or LY294002, the specific inhibitors of MEK1/2 and PI3K, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	mitogen activated protein kinase kinase 1	Rattus norvegicus	226-232
25339702-7	2015	Inhibition of PI3-kinase (PI3-K) with LY294002 (20 muM) abrogates activation of ClC-K2 by IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	14-24
25339702-7	2015	Inhibition of PI3-kinase (PI3-K) with LY294002 (20 muM) abrogates activation of ClC-K2 by IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	chloride channel, voltage-sensitive Kb	Mus musculus	80-86
25339702-7	2015	Inhibition of PI3-kinase (PI3-K) with LY294002 (20 muM) abrogates activation of ClC-K2 by IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	insulin-like growth factor 1	Mus musculus	90-95
25463525-9	2015	infusions of LY294002 (10 nmol/side), a specific phosphatidylinositol 3-kinase (PI3K) inhibitor, significantly prevented the antidepressant-like effect of ALC (100mg/kg, i.p.).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	49-78
25555490-9	2015	However, LY294002, a selective PI3K inhibitor, not only eliminated the neuroprotection of sevoflurane, as indicated by an increased infarct size and a larger number of TUNEL-positive cells, but also reversed the elevation of p-Akt and p-GSK-3beta expression in the mitochondria induced by sevoflurane post-conditioning.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Rattus norvegicus	227-230
25555490-9	2015	However, LY294002, a selective PI3K inhibitor, not only eliminated the neuroprotection of sevoflurane, as indicated by an increased infarct size and a larger number of TUNEL-positive cells, but also reversed the elevation of p-Akt and p-GSK-3beta expression in the mitochondria induced by sevoflurane post-conditioning.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	glycogen synthase kinase 3 beta	Rattus norvegicus	237-246
25490383-6	2015	The combination treatment with PI3K inhibitors (LY294002 or wortmannin) or knockdown AKT expression by specific small interfering RNA could decrease tamoxifen-induced MSH2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	mutS homolog 2	Homo sapiens	167-171
24975165-7	2015	LY294002 and IC87114 prevented Akt phosphorylation as expected and down-regulated the expression of inflammatory factors IL-6, MCP-1,TNFalpha and iNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 6	Mus musculus	121-125
24975165-7	2015	LY294002 and IC87114 prevented Akt phosphorylation as expected and down-regulated the expression of inflammatory factors IL-6, MCP-1,TNFalpha and iNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mast cell protease 1	Mus musculus	127-132
24975165-7	2015	LY294002 and IC87114 prevented Akt phosphorylation as expected and down-regulated the expression of inflammatory factors IL-6, MCP-1,TNFalpha and iNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Mus musculus	133-141
24975165-7	2015	LY294002 and IC87114 prevented Akt phosphorylation as expected and down-regulated the expression of inflammatory factors IL-6, MCP-1,TNFalpha and iNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 2, inducible	Mus musculus	146-150
26075254-5	2015	LY294002-mediated inhibition of phosphatidylinositol-3 kinase, which is an upstream effector for Akt activation, increased cleavage of poly(ADP-ribosyl) polymerase (PARP) but ERK inhibition by U0126 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	97-100
26424017-0	2015	PI3-Kinase Inhibitor LY294002 Repressed the Expression of Thrombin-Activatable Fibrinolysis Inhibitor in Human Hepatoma HepG2 Cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	carboxypeptidase B2	Homo sapiens	58-101
26424017-8	2015	The half-life of the CPB2 transcript was shortened by treatment with LY294002 compared with control.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	carboxypeptidase B2	Homo sapiens	21-25
26424017-9	2015	The present results suggest that the PI3K inhibitor LY294002 suppresses expression of TAFI, a prothrombotic factor, by decreasing the stability of CPB2 transcripts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	carboxypeptidase B2	Homo sapiens	147-151
26770978-8	2015	The expression of P-AKT(Ser473) further decreased following pretreatment with LY294002 and the expression of P-GSK-3beta(Ser9) increased following pretreatment with LiCl.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	AKT serine/threonine kinase 1	Rattus norvegicus	20-23
25308520-8	2015	In addition, the aforementioned promotive effects afforded by CTI were abolished by blocking PI3K/AKT pathway with addition of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	98-101
25866755-1	2015	The purpose of this paper is to explore the change of NF-kappaB signaling pathway in intestinal epithelial cell induced by fission neutron irradiation and the influence of the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	AKT serine/threonine kinase 1	Rattus norvegicus	181-184
26075254-5	2015	LY294002-mediated inhibition of phosphatidylinositol-3 kinase, which is an upstream effector for Akt activation, increased cleavage of poly(ADP-ribosyl) polymerase (PARP) but ERK inhibition by U0126 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	135-163
26075254-5	2015	LY294002-mediated inhibition of phosphatidylinositol-3 kinase, which is an upstream effector for Akt activation, increased cleavage of poly(ADP-ribosyl) polymerase (PARP) but ERK inhibition by U0126 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	165-169
26075254-5	2015	LY294002-mediated inhibition of phosphatidylinositol-3 kinase, which is an upstream effector for Akt activation, increased cleavage of poly(ADP-ribosyl) polymerase (PARP) but ERK inhibition by U0126 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 1	Homo sapiens	175-178
25701261-5	2015	Treatment with ERK or Akt specific inhibitors, U0126 or LY294002, respectively, suppressed estradiol-induced growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	mitogen-activated protein kinase 1	Homo sapiens	15-18
25701261-5	2015	Treatment with ERK or Akt specific inhibitors, U0126 or LY294002, respectively, suppressed estradiol-induced growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	22-25
26207671-8	2015	Treatment of Snail-overexpressing 22Rv1 cells with LY294002, PI3K/AKT inhibitor or U0126, MEK inhibitor, decreased cell migration significantly, but only LY294002 significantly reduced Rac1 activity, suggesting that Snail promotes Rac1 activation via the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	snail family transcriptional repressor 1	Homo sapiens	13-18
26121010-5	2015	The effect of leptin on IL-8 could visibly abolished by the inhibitor of PI3K LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
26207671-8	2015	Treatment of Snail-overexpressing 22Rv1 cells with LY294002, PI3K/AKT inhibitor or U0126, MEK inhibitor, decreased cell migration significantly, but only LY294002 significantly reduced Rac1 activity, suggesting that Snail promotes Rac1 activation via the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	snail family transcriptional repressor 1	Homo sapiens	216-221
26207671-8	2015	Treatment of Snail-overexpressing 22Rv1 cells with LY294002, PI3K/AKT inhibitor or U0126, MEK inhibitor, decreased cell migration significantly, but only LY294002 significantly reduced Rac1 activity, suggesting that Snail promotes Rac1 activation via the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	snail family transcriptional repressor 1	Homo sapiens	13-18
26517864-9	2015	Moreover, the NO synthase antagonist L-NAME and PI3K inhibitor LY294002 dramatically abolished the inhibitory effects of bradykinin on tissue factor expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	coagulation factor III	Mus musculus	135-148
26207671-8	2015	Treatment of Snail-overexpressing 22Rv1 cells with LY294002, PI3K/AKT inhibitor or U0126, MEK inhibitor, decreased cell migration significantly, but only LY294002 significantly reduced Rac1 activity, suggesting that Snail promotes Rac1 activation via the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	Rac family small GTPase 1	Homo sapiens	185-189
25802931-6	2015	Blocking PI3K/Akt signaling with LY-294002 enhanced DLK kinase activity dramatically.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-42	thymoma viral proto-oncogene 1	Mus musculus	14-17
25802931-6	2015	Blocking PI3K/Akt signaling with LY-294002 enhanced DLK kinase activity dramatically.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-42	mitogen-activated protein kinase kinase kinase 12	Mus musculus	52-55
26488172-10	2015	This enhancement was also markedly abolished by co-incubation with LY294002, paralleled with suppressed Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Homo sapiens	104-107
25173778-5	2015	The PI3K inhibitor LY294002 was used to investigate the possible mechanism relating the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	93-96
25714853-7	2015	Treatment with Dovitinib in combination with PI3K/Akt/mTOR signaling inhibitors Ly294002 or RAD001 resulted in additive inhibition of cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	50-53
25714853-7	2015	Treatment with Dovitinib in combination with PI3K/Akt/mTOR signaling inhibitors Ly294002 or RAD001 resulted in additive inhibition of cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	mechanistic target of rapamycin kinase	Homo sapiens	54-58
26517864-9	2015	Moreover, the NO synthase antagonist L-NAME and PI3K inhibitor LY294002 dramatically abolished the inhibitory effects of bradykinin on tissue factor expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	kininogen 1	Homo sapiens	121-131
25591759-7	2015	TSLP increased Akt phosphorylation, an effect that was abrogated by the PI3K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	thymic stromal lymphopoietin	Mus musculus	0-4
25506687-7	2015	In vitro, DFO significantly increased the tube formation and expression of angiogenic factors in CD34-positive cells, which were blocked by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	CD34 antigen	Mus musculus	97-101
25824462-12	2015	The effect of Lenti-PIK3R2 shRNA was reduced by LY294002, a specific inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	phosphoinositide-3-kinase regulatory subunit 2	Rattus norvegicus	20-26
26138882-7	2015	Our data also showed that the mineralcorticoid receptor (MR) antagonist spironolactone, ERK1/2 inhibitor PD98059 and PKC inhibitor GF109203X could attenuate the down-regulation of Cx43 expression in Aldo-induced MC proliferation; however, the PI3K inhibitor LY294002 could block MC proliferation without affecting Cx43 expression at either the mRNA or protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	258-266	mitogen-activated protein kinase 3	Homo sapiens	88-94
26138882-7	2015	Our data also showed that the mineralcorticoid receptor (MR) antagonist spironolactone, ERK1/2 inhibitor PD98059 and PKC inhibitor GF109203X could attenuate the down-regulation of Cx43 expression in Aldo-induced MC proliferation; however, the PI3K inhibitor LY294002 could block MC proliferation without affecting Cx43 expression at either the mRNA or protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	258-266	gap junction protein alpha 1	Homo sapiens	180-184
26159150-6	2015	In addition, ZY-1A4 concentration- and time-dependently induced HO-1 expression associated with degradation of Kelch-like ECH-associated protein 1 (Keap1) and nuclear translocation of Nrf2, while the effect of ZY-1A4 was abolished by a phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	279-287	heme oxygenase 1	Homo sapiens	64-68
26159150-8	2015	Furthermore, the inhibitory effect of ZY-1A4 on LPS-induced iNOS expression and NO release was abolished by HO-1 siRNA or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	nitric oxide synthase 2	Homo sapiens	60-64
26202364-10	2015	PI3K inhibitor LY294002 abrogated miR-497 inhibitors induced cisplatin resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	microRNA 497	Homo sapiens	34-41
25766527-7	2015	Furthermore, in both the IS and RS models with Gas6 treatment, the levels of PI3K, p-Akt, and p-FoxO3a decreased following Axl inhibition by R428; similarly, the levels of p-Akt and p-FoxO3a also decreased following PI3K inhibition by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	235-243	growth arrest specific 6	Homo sapiens	47-51
25833462-8	2015	VEGFR2 inhibitor SU-1498, AKT inhibitor LY294002 and FAK inhibitor 14 (FAK inhibitor) blocked the Robo4 knockdown-mediated alteration in glioma angiogenesis in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	26-29
25833462-8	2015	VEGFR2 inhibitor SU-1498, AKT inhibitor LY294002 and FAK inhibitor 14 (FAK inhibitor) blocked the Robo4 knockdown-mediated alteration in glioma angiogenesis in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	roundabout guidance receptor 4	Homo sapiens	98-103
25591759-7	2015	TSLP increased Akt phosphorylation, an effect that was abrogated by the PI3K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	thymoma viral proto-oncogene 1	Mus musculus	15-18
26642720-8	2015	LY294002 blocked the increase in phospho-AKT evoked by Cbx and abolished the associated protective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
24846128-9	2015	In addition, LY294002, a phosphoinositide 3-kinase inhibitor, prevented the quantitative and distributional changes of CD2AP induced by high glucose and AGE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	CD2-associated protein	Rattus norvegicus	119-124
24647791-15	2015	LY294002 and U0126 attenuated IL-1beta-induced ICAM-1 expression and sICAM-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 beta	Homo sapiens	30-38
24647791-15	2015	LY294002 and U0126 attenuated IL-1beta-induced ICAM-1 expression and sICAM-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	intercellular adhesion molecule 1	Homo sapiens	47-53
25544681-6	2015	The current study revealed that LY294002 (an inhibitor for phosphatidyl inositol 3-kinase, PI3K), PP1 (inhibitor for c-Src), GW9662 (antagonist for peroxisome proliferator-activated receptor gamma, PPARgamma), H89 (an inhibitor for protein kinase A, PKA) and AG1478 (an antagonist for epidermal growth factor receptor, EGFR) prohibited the up-regulation of IDE induced by geniposide in primary cortical neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	148-196
25360842-9	2015	The specific PI3 kinase inhibitor LY294002 blocked ET-1-induced Akt and ERK1/2 phosphorylation, and protein synthesis in CMs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	endothelin 1	Rattus norvegicus	51-55
25360842-9	2015	The specific PI3 kinase inhibitor LY294002 blocked ET-1-induced Akt and ERK1/2 phosphorylation, and protein synthesis in CMs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	mitogen activated protein kinase 3	Rattus norvegicus	72-78
25705234-4	2015	Results of western blot analysis revealed that the selective phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 suppressed icariin-induced Akt phosphorylation, suggesting that the protective effects of icariin are associated with activation of the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	61-90
25531265-10	2015	Only PI3K/AKT inhibitor (LY294002), but not ERK inhibitor (PD98059), completely blocked the 6-OH-BDE-47 induced up regulation of Snail and down regulation of E-Cad, suggesting that PI3K/AKT pathway is important for 6-OH-BDE-47-mediated Snail stabilization and EMT in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	10-13
25531265-10	2015	Only PI3K/AKT inhibitor (LY294002), but not ERK inhibitor (PD98059), completely blocked the 6-OH-BDE-47 induced up regulation of Snail and down regulation of E-Cad, suggesting that PI3K/AKT pathway is important for 6-OH-BDE-47-mediated Snail stabilization and EMT in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	snail family transcriptional repressor 1	Homo sapiens	129-134
25531265-10	2015	Only PI3K/AKT inhibitor (LY294002), but not ERK inhibitor (PD98059), completely blocked the 6-OH-BDE-47 induced up regulation of Snail and down regulation of E-Cad, suggesting that PI3K/AKT pathway is important for 6-OH-BDE-47-mediated Snail stabilization and EMT in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	cadherin 1	Homo sapiens	158-163
25705234-4	2015	Results of western blot analysis revealed that the selective phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 suppressed icariin-induced Akt phosphorylation, suggesting that the protective effects of icariin are associated with activation of the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Rattus norvegicus	144-147
25705234-4	2015	Results of western blot analysis revealed that the selective phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 suppressed icariin-induced Akt phosphorylation, suggesting that the protective effects of icariin are associated with activation of the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Rattus norvegicus	258-261
25705234-5	2015	LY294002 also blocked the icariin-induced downregulation of proapoptotic factors Bax and caspase-3 and upregulation of antiapoptotic factor Bcl-2 in Abeta 25-35-treated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	81-84
25705234-5	2015	LY294002 also blocked the icariin-induced downregulation of proapoptotic factors Bax and caspase-3 and upregulation of antiapoptotic factor Bcl-2 in Abeta 25-35-treated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Rattus norvegicus	89-98
25705234-5	2015	LY294002 also blocked the icariin-induced downregulation of proapoptotic factors Bax and caspase-3 and upregulation of antiapoptotic factor Bcl-2 in Abeta 25-35-treated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2, apoptosis regulator	Rattus norvegicus	140-145
25446723-7	2015	In addition, we show that neurocan, aggrecan, and brevican levels are significantly reduced when TGFbeta is administered in the presence of either the PI3K inhibitor LY294002 or the mTOR inhibitor rapamycin, but not the MEK1/2 inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	transforming growth factor beta 1	Homo sapiens	97-104
25446723-7	2015	In addition, we show that neurocan, aggrecan, and brevican levels are significantly reduced when TGFbeta is administered in the presence of either the PI3K inhibitor LY294002 or the mTOR inhibitor rapamycin, but not the MEK1/2 inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	mitogen-activated protein kinase kinase 1	Homo sapiens	220-226
25352364-5	2015	The acetylation of p300 and the phosphorylation of activating transcription factor 2 (ATF-2) induced by LPS were downregulated following treatment with veratric acid; similar effects were observed following treatment with LY294002, a specific inhibitor of PI3K/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	222-230	E1A binding protein p300	Mus musculus	19-23
25968948-11	2015	Inhibition of the PI3K/Akt pathway by the Akt inhibitor LY294002 was associated with a decrease in miR-210 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
25968948-11	2015	Inhibition of the PI3K/Akt pathway by the Akt inhibitor LY294002 was associated with a decrease in miR-210 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Rattus norvegicus	42-45
25968948-11	2015	Inhibition of the PI3K/Akt pathway by the Akt inhibitor LY294002 was associated with a decrease in miR-210 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	microRNA 210	Rattus norvegicus	99-106
26653825-0	2015	LY294002 induces in vitro apoptosis and overexpression of p75NTR in human uterine leiomyosarcoma HTB 114 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nerve growth factor receptor	Homo sapiens	58-64
26653825-5	2015	According to the type of exposure, LY294002 not only induced a relevant increase in apoptosis, but also produced a novel and unexpected phenotypic modulation of the NGF receptors with a downregulation of TrKA and an upregulation of p75NTR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	neurotrophic receptor tyrosine kinase 1	Homo sapiens	204-208
26653825-5	2015	According to the type of exposure, LY294002 not only induced a relevant increase in apoptosis, but also produced a novel and unexpected phenotypic modulation of the NGF receptors with a downregulation of TrKA and an upregulation of p75NTR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	nerve growth factor receptor	Homo sapiens	232-238
25434308-8	2015	Meanwhile, FZD treatment inhibited both the activation and expression of Akt, and PI3K/Akt inhibitor LY294002 promoted FZD-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Homo sapiens	87-90
25552923-15	2015	The improvement of NGF on recovery of cardiac function and alleviation of myocardial injury were completely abolished by K252a or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	nerve growth factor	Rattus norvegicus	19-22
25552923-18	2015	When the activation of PI3K/Akt pathway is blocked by LY294002, the NGF induced suppression of the apoptosis-related proteins expression was reversed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
25352364-5	2015	The acetylation of p300 and the phosphorylation of activating transcription factor 2 (ATF-2) induced by LPS were downregulated following treatment with veratric acid; similar effects were observed following treatment with LY294002, a specific inhibitor of PI3K/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	222-230	activating transcription factor 2	Mus musculus	51-84
25352364-5	2015	The acetylation of p300 and the phosphorylation of activating transcription factor 2 (ATF-2) induced by LPS were downregulated following treatment with veratric acid; similar effects were observed following treatment with LY294002, a specific inhibitor of PI3K/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	222-230	activating transcription factor 2	Mus musculus	86-91
25552923-18	2015	When the activation of PI3K/Akt pathway is blocked by LY294002, the NGF induced suppression of the apoptosis-related proteins expression was reversed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	nerve growth factor	Rattus norvegicus	68-71
25352364-5	2015	The acetylation of p300 and the phosphorylation of activating transcription factor 2 (ATF-2) induced by LPS were downregulated following treatment with veratric acid; similar effects were observed following treatment with LY294002, a specific inhibitor of PI3K/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	222-230	thymoma viral proto-oncogene 1	Mus musculus	261-264
25352364-7	2015	In the measurement of histone acetylation levels, the LPS-stimulated acetylation of histone H4 was significantly attenuated by veratric acid, and was also reduced following the inhibition of PI3K/Akt with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	thymoma viral proto-oncogene 1	Mus musculus	196-199
25695094-6	2015	We also found that pretreatment with LY294002 (an inhibitor of phosphatidylinositol 3-kinase) abolished high glucose-induced expression of fibronectin, collagen IV, and laminin in RPE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	fibronectin 1	Homo sapiens	139-150
24958127-7	2015	Furthermore, the treatment with LY294002 (50 mumol/L) and Wortmannin (10nmol/L), inhibitors of phosphatidylinositol 3-kinase (PI3K), significantly decreased the amplified VEGF(120) secretion by 29% (p &lt; 0.01) and 28% (p &lt; 0.01) relative to the cells stimulated by ghrelin alone, respectively, whereas these inhibitors had no effects on increased MCP-1 release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	C-C motif chemokine ligand 2	Homo sapiens	352-357
25303486-11	2015	WNT5a overexpression also enhanced the expression of inflammation-related genes and increased intracellular reactive oxygen species, whereas both BAY-117082 and LY-294002 (phosphatidylinositol 3-kinase inhibitor) significantly inhibited WNT5a-induced inflammation and oxidative stress.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-170	Wnt family member 5A	Homo sapiens	237-242
25313909-13	2015	Treatment with GnRH induces AKT phosphorylation and Phosphoinositide3-kinase inhibitor LY294002 attenuates the effects of GnRH on TWIST and N-cadherin expression and trophoblastic cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	gonadotropin releasing hormone 1	Homo sapiens	15-19
25313909-13	2015	Treatment with GnRH induces AKT phosphorylation and Phosphoinositide3-kinase inhibitor LY294002 attenuates the effects of GnRH on TWIST and N-cadherin expression and trophoblastic cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	gonadotropin releasing hormone 1	Homo sapiens	122-126
25313909-13	2015	Treatment with GnRH induces AKT phosphorylation and Phosphoinositide3-kinase inhibitor LY294002 attenuates the effects of GnRH on TWIST and N-cadherin expression and trophoblastic cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	twist family bHLH transcription factor 1	Homo sapiens	130-135
25313909-13	2015	Treatment with GnRH induces AKT phosphorylation and Phosphoinositide3-kinase inhibitor LY294002 attenuates the effects of GnRH on TWIST and N-cadherin expression and trophoblastic cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	cadherin 2	Homo sapiens	140-150
25510413-6	2015	In parallel, the interaction between the level of BCL2, BAX and PTEN with the specific PI3K/AKT inhibitor-LY294002 was highly significant for BCL2 and nearly significant for PTEN and BAX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	BCL2 apoptosis regulator	Homo sapiens	50-54
25510413-6	2015	In parallel, the interaction between the level of BCL2, BAX and PTEN with the specific PI3K/AKT inhibitor-LY294002 was highly significant for BCL2 and nearly significant for PTEN and BAX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	BCL2 associated X, apoptosis regulator	Homo sapiens	56-59
25510413-6	2015	In parallel, the interaction between the level of BCL2, BAX and PTEN with the specific PI3K/AKT inhibitor-LY294002 was highly significant for BCL2 and nearly significant for PTEN and BAX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	phosphatase and tensin homolog	Homo sapiens	64-68
26390889-5	2015	It suggested that, the blockade of PI3K activation by LY294002, a specific inhibitor of the PI3K/Akt signaling pathway in osteoblasts, heavily inhibited cell proliferation, ALP activity, calcium accumulation, and mRNA expression of OCN, Osterix and Runx2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
26390889-5	2015	It suggested that, the blockade of PI3K activation by LY294002, a specific inhibitor of the PI3K/Akt signaling pathway in osteoblasts, heavily inhibited cell proliferation, ALP activity, calcium accumulation, and mRNA expression of OCN, Osterix and Runx2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	bone gamma-carboxyglutamate protein	Rattus norvegicus	232-235
25510413-6	2015	In parallel, the interaction between the level of BCL2, BAX and PTEN with the specific PI3K/AKT inhibitor-LY294002 was highly significant for BCL2 and nearly significant for PTEN and BAX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	AKT serine/threonine kinase 1	Homo sapiens	92-95
26390889-5	2015	It suggested that, the blockade of PI3K activation by LY294002, a specific inhibitor of the PI3K/Akt signaling pathway in osteoblasts, heavily inhibited cell proliferation, ALP activity, calcium accumulation, and mRNA expression of OCN, Osterix and Runx2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	Sp7 transcription factor	Rattus norvegicus	237-244
26390889-5	2015	It suggested that, the blockade of PI3K activation by LY294002, a specific inhibitor of the PI3K/Akt signaling pathway in osteoblasts, heavily inhibited cell proliferation, ALP activity, calcium accumulation, and mRNA expression of OCN, Osterix and Runx2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	RUNX family transcription factor 2	Rattus norvegicus	249-254
25510413-6	2015	In parallel, the interaction between the level of BCL2, BAX and PTEN with the specific PI3K/AKT inhibitor-LY294002 was highly significant for BCL2 and nearly significant for PTEN and BAX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	BCL2 apoptosis regulator	Homo sapiens	142-146
25510413-6	2015	In parallel, the interaction between the level of BCL2, BAX and PTEN with the specific PI3K/AKT inhibitor-LY294002 was highly significant for BCL2 and nearly significant for PTEN and BAX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	phosphatase and tensin homolog	Homo sapiens	174-178
25510413-6	2015	In parallel, the interaction between the level of BCL2, BAX and PTEN with the specific PI3K/AKT inhibitor-LY294002 was highly significant for BCL2 and nearly significant for PTEN and BAX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	BCL2 associated X, apoptosis regulator	Homo sapiens	183-186
25969626-10	2015	Here, LY294002, a specific PI3K/Akt inhibitor, suppressed PUN-induced HO-1 expression and led to ROS accumulation in macrophages.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	AKT serine/threonine kinase 1	Homo sapiens	32-35
26078825-7	2015	The specific PTEN and PI3K inhibitors, BPV(pic) and LY294002, influence ENaC activity in AGEs-pretreated A6 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	phosphatase and tensin homolog	Homo sapiens	13-17
25148875-10	2015	Interestingly, the effects of miR-181b on the activation of HSCs were blocked down by Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	AKT serine/threonine kinase 1	Rattus norvegicus	86-89
25590369-10	2015	We also found that the phosphatidylinositol 3-kinase inhibitor LY294002 could block LC3-I/LC3-II conversion and increase B-cell lymphoma 2 while decreasing hVps34 and Beclin-1 expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	annexin A3	Rattus norvegicus	84-87
26273426-7	2015	But the ERK inhibitor U0126 or PI3K/Akt inhibitor LY294002 produced no obvious effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	36-39
26448817-5	2015	Inactivation of FoxO3a triggered by PI3K inhibitor LY294002 prevented the myostatin-induced increase of expression of MuRF1, MAFbx, and LC3-II protein in C2C12 myotubes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	forkhead box O3	Rattus norvegicus	16-22
26448817-5	2015	Inactivation of FoxO3a triggered by PI3K inhibitor LY294002 prevented the myostatin-induced increase of expression of MuRF1, MAFbx, and LC3-II protein in C2C12 myotubes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	myostatin	Rattus norvegicus	74-83
26448817-5	2015	Inactivation of FoxO3a triggered by PI3K inhibitor LY294002 prevented the myostatin-induced increase of expression of MuRF1, MAFbx, and LC3-II protein in C2C12 myotubes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	tripartite motif containing 63	Rattus norvegicus	118-123
26448817-5	2015	Inactivation of FoxO3a triggered by PI3K inhibitor LY294002 prevented the myostatin-induced increase of expression of MuRF1, MAFbx, and LC3-II protein in C2C12 myotubes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	F-box protein 32	Rattus norvegicus	125-130
25590369-10	2015	We also found that the phosphatidylinositol 3-kinase inhibitor LY294002 could block LC3-I/LC3-II conversion and increase B-cell lymphoma 2 while decreasing hVps34 and Beclin-1 expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	annexin A3	Rattus norvegicus	90-93
25590369-10	2015	We also found that the phosphatidylinositol 3-kinase inhibitor LY294002 could block LC3-I/LC3-II conversion and increase B-cell lymphoma 2 while decreasing hVps34 and Beclin-1 expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	156-162
25590369-10	2015	We also found that the phosphatidylinositol 3-kinase inhibitor LY294002 could block LC3-I/LC3-II conversion and increase B-cell lymphoma 2 while decreasing hVps34 and Beclin-1 expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	beclin 1	Rattus norvegicus	167-175
25542689-7	2014	Moreover, we also demonstrated the effects of intra-hippocampus infusion of LY294002 (10 nmol/side), a specific phosphatidylinositol 3-kinase inhibitor prior to the treatment of GLYX-13 in the forced swim test.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	112-141
25266803-7	2015	The blockade of the PI3K/Akt pathway by LY294002 resulted in abolishment of the effects of RhoGDI2 shRNA in Akt phosphorylation and MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	25-28
25266803-7	2015	The blockade of the PI3K/Akt pathway by LY294002 resulted in abolishment of the effects of RhoGDI2 shRNA in Akt phosphorylation and MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	Rho GDP dissociation inhibitor beta	Homo sapiens	91-98
25266803-7	2015	The blockade of the PI3K/Akt pathway by LY294002 resulted in abolishment of the effects of RhoGDI2 shRNA in Akt phosphorylation and MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	108-111
25266803-7	2015	The blockade of the PI3K/Akt pathway by LY294002 resulted in abolishment of the effects of RhoGDI2 shRNA in Akt phosphorylation and MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	matrix metallopeptidase 9	Homo sapiens	132-137
25993800-10	2015	These effects were inhibited by LY294002, a blocker of PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
25529839-11	2015	Interestingly, LY294002, an inhibitor of phosphatidylinositol 3-kinase, abolished the EPS-stimulated GSH synthesis, suggesting that the kinase is associated with Nrf2 activation induced by EPS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	162-166
25542689-12	2014	Moreover, intra-hippocampus infusion of LY294002 significantly abolished the antidepressant-like effects and upregulation on phosphatidylinositol 3-kinase/AKT/mTOR/VGF signaling of GLYX-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	125-154
25542689-12	2014	Moreover, intra-hippocampus infusion of LY294002 significantly abolished the antidepressant-like effects and upregulation on phosphatidylinositol 3-kinase/AKT/mTOR/VGF signaling of GLYX-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	thymoma viral proto-oncogene 1	Mus musculus	155-158
25542689-12	2014	Moreover, intra-hippocampus infusion of LY294002 significantly abolished the antidepressant-like effects and upregulation on phosphatidylinositol 3-kinase/AKT/mTOR/VGF signaling of GLYX-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	mechanistic target of rapamycin kinase	Mus musculus	159-163
25542689-12	2014	Moreover, intra-hippocampus infusion of LY294002 significantly abolished the antidepressant-like effects and upregulation on phosphatidylinositol 3-kinase/AKT/mTOR/VGF signaling of GLYX-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	VGF nerve growth factor inducible	Mus musculus	164-167
25445040-3	2014	Specific inhibitors of growth-related signal transducers, such as AG1478, LY294002, PD98059, and rapamycin, completely abolished IL-1beta-stimulated hepatocyte DNA synthesis and proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	interleukin 1 beta	Homo sapiens	129-137
25450674-10	2014	In the migrating preadipocytes, ARF6 activation was inhibited with SecinH3 (cytohesin inhibitor) and LY294002 (PI3K inhibitor) whereas the ERK1/2 phosphorylation was inhibited with SecinH3, LY294002, PBP10 (a PIP2 sequester peptide) and PD98059 (MAPKK inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	ADP ribosylation factor 6	Homo sapiens	32-36
25450674-10	2014	In the migrating preadipocytes, ARF6 activation was inhibited with SecinH3 (cytohesin inhibitor) and LY294002 (PI3K inhibitor) whereas the ERK1/2 phosphorylation was inhibited with SecinH3, LY294002, PBP10 (a PIP2 sequester peptide) and PD98059 (MAPKK inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	ADP ribosylation factor 6	Homo sapiens	32-36
25296388-3	2014	Among these compounds, compound 4l exhibited the most potent and selective activity for PI3Kalpha, with the value of 0.014 muM, an approximately 30-fold increase in comparison with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	88-97
25446117-5	2014	The COMP-Ang1-mediated increases were inhibited by Tie-2 knockdown and by treating inhibitors of phosphoinositide 3-kinase (PI3K), LY294002, or p38 mitogen-activated protein kinase (MAPK), SB203580.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	cartilage oligomeric matrix protein	Homo sapiens	4-8
25446117-5	2014	The COMP-Ang1-mediated increases were inhibited by Tie-2 knockdown and by treating inhibitors of phosphoinositide 3-kinase (PI3K), LY294002, or p38 mitogen-activated protein kinase (MAPK), SB203580.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	angiopoietin 1	Homo sapiens	9-13
25486532-5	2014	Overexpression of a rapamycin-resistant mutant of S6K1 further enhanced the inhibitory effect of LY294002 on the SP600125-induced polyploidization of Dami and CMK cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	ribosomal protein S6 kinase B1	Homo sapiens	50-54
25450677-6	2014	The enhanced myoblast differentiation by THP treatment can be blocked by inhibition of p38MAPK or Akt by SB203580 or LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	mitogen-activated protein kinase 14	Mus musculus	87-94
25450677-6	2014	The enhanced myoblast differentiation by THP treatment can be blocked by inhibition of p38MAPK or Akt by SB203580 or LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	thymoma viral proto-oncogene 1	Mus musculus	98-101
25173817-7	2014	Moreover, gefitinib, and LY294002 and MK2206 compounds inhibited IRES-mediated Sp1 translation, implying that activation of the epithelial growth factor receptor (EGFR) pathway via Akt activation triggers the IRES pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	epidermal growth factor receptor	Homo sapiens	128-161
25474202-6	2014	The promotion effects were blocked by PI3K-specific inhibitor (LY294002), but not MAPK inhibitor (PD98059); levels of phospho-Akt were increased by IGF-1 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	insulin-like growth factor 1	Rattus norvegicus	148-153
25173817-7	2014	Moreover, gefitinib, and LY294002 and MK2206 compounds inhibited IRES-mediated Sp1 translation, implying that activation of the epithelial growth factor receptor (EGFR) pathway via Akt activation triggers the IRES pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	epidermal growth factor receptor	Homo sapiens	163-167
25263523-8	2014	LY294002 inhibited the effects of HG or IGF-1 on Cbfa1 activity, indicating that HG and IGF-1 could increase Cbfa1 activity via PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 1	Homo sapiens	40-45
25263523-8	2014	LY294002 inhibited the effects of HG or IGF-1 on Cbfa1 activity, indicating that HG and IGF-1 could increase Cbfa1 activity via PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	RUNX family transcription factor 2	Homo sapiens	49-54
25263523-8	2014	LY294002 inhibited the effects of HG or IGF-1 on Cbfa1 activity, indicating that HG and IGF-1 could increase Cbfa1 activity via PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 1	Homo sapiens	88-93
25263523-8	2014	LY294002 inhibited the effects of HG or IGF-1 on Cbfa1 activity, indicating that HG and IGF-1 could increase Cbfa1 activity via PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	RUNX family transcription factor 2	Homo sapiens	109-114
25027991-13	2014	Additionally, treatment of phosphatidylinositol 3-kinase inhibitor LY294002 could arrest cells growth and diminish SGTA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	small glutamine rich tetratricopeptide repeat co-chaperone alpha	Homo sapiens	115-119
25310590-3	2014	LY294002 is a commonly used pharmacologic inhibitor, which selectively inhibits the phosphoinositide 3-kinase-AKT nexus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	110-113
25385842-8	2014	Insulin-induced TFR1 expression was blocked by IRP2, but not by IRP1 interference, and disappeared when HL-7702 cells were pretreated with LY294002, triciribine hydrate, or rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	transferrin receptor	Rattus norvegicus	16-20
25598661-7	2014	In addition, treatment with LY294002, SB202190, or SP600125 resulted in significantly attenuated secretion of IL-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	interleukin 1 alpha	Homo sapiens	110-119
23147834-5	2014	We demonstrate that pharmacological inhibition via LY294002 results in abrogation of CNTF-mediated viability, suggesting that the CNTF-mediated MPC viability benefit occurs via the PI3-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	ciliary neurotrophic factor	Mus musculus	85-89
23147834-5	2014	We demonstrate that pharmacological inhibition via LY294002 results in abrogation of CNTF-mediated viability, suggesting that the CNTF-mediated MPC viability benefit occurs via the PI3-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	ciliary neurotrophic factor	Mus musculus	130-134
23147834-5	2014	We demonstrate that pharmacological inhibition via LY294002 results in abrogation of CNTF-mediated viability, suggesting that the CNTF-mediated MPC viability benefit occurs via the PI3-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	181-184
23147834-5	2014	We demonstrate that pharmacological inhibition via LY294002 results in abrogation of CNTF-mediated viability, suggesting that the CNTF-mediated MPC viability benefit occurs via the PI3-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	thymoma viral proto-oncogene 1	Mus musculus	185-188
25344912-5	2014	Inhibition of the PI3K/AKT pathway with specific inhibitors, wortmannin and LY294002, significantly reduced Bcl-xL expression, induced caspase-3-dependent apoptosis, and repressed cell proliferation and tumor growth in vitro and in vivo without obvious toxic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	23-26
25454762-9	2014	The functional aspects of the PI3K/Akt signaling pathway were analyzed with LY294002, which is a specific PI3K/Akt inhibitor that attenuated LPS-induced iNOS and COX-2 expression by suppressing NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	thymoma viral proto-oncogene 1	Mus musculus	35-38
25454762-9	2014	The functional aspects of the PI3K/Akt signaling pathway were analyzed with LY294002, which is a specific PI3K/Akt inhibitor that attenuated LPS-induced iNOS and COX-2 expression by suppressing NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	thymoma viral proto-oncogene 1	Mus musculus	111-114
25454762-9	2014	The functional aspects of the PI3K/Akt signaling pathway were analyzed with LY294002, which is a specific PI3K/Akt inhibitor that attenuated LPS-induced iNOS and COX-2 expression by suppressing NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	nitric oxide synthase 2, inducible	Mus musculus	153-157
25454762-9	2014	The functional aspects of the PI3K/Akt signaling pathway were analyzed with LY294002, which is a specific PI3K/Akt inhibitor that attenuated LPS-induced iNOS and COX-2 expression by suppressing NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	prostaglandin-endoperoxide synthase 2	Mus musculus	162-167
25230779-12	2014	Notably, Akt inhibition by LY294002 restored the 5-FU cytotoxicity suppressed by CD133 overexpression, while Akt activation by epidermal growth factor reversed the 5-FU cytotoxicity enhanced by CD133 silencing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	9-12
25149157-5	2014	Moreover, treatment of A549 cells with LicA-inhibited activation of the phosphorylation of Akt and inhibition of Akt by LY294002 (PI3K inhibitor) or transfection with the constitutive active-Akt (CA-Akt) expression vector significantly abolished the LicA-inhibited migration and invasion through activation of the Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	113-116
25149157-5	2014	Moreover, treatment of A549 cells with LicA-inhibited activation of the phosphorylation of Akt and inhibition of Akt by LY294002 (PI3K inhibitor) or transfection with the constitutive active-Akt (CA-Akt) expression vector significantly abolished the LicA-inhibited migration and invasion through activation of the Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	113-116
25149157-5	2014	Moreover, treatment of A549 cells with LicA-inhibited activation of the phosphorylation of Akt and inhibition of Akt by LY294002 (PI3K inhibitor) or transfection with the constitutive active-Akt (CA-Akt) expression vector significantly abolished the LicA-inhibited migration and invasion through activation of the Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	113-116
25149157-5	2014	Moreover, treatment of A549 cells with LicA-inhibited activation of the phosphorylation of Akt and inhibition of Akt by LY294002 (PI3K inhibitor) or transfection with the constitutive active-Akt (CA-Akt) expression vector significantly abolished the LicA-inhibited migration and invasion through activation of the Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	113-116
25449069-5	2014	LY294002 could reduce the phosphorylation of Akt and GSK3beta (P&lt; 0.01, P&lt; 0.05), and also decrease the DRD2 mRNA (P&lt;0 .05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	45-48
25449069-5	2014	LY294002 could reduce the phosphorylation of Akt and GSK3beta (P&lt; 0.01, P&lt; 0.05), and also decrease the DRD2 mRNA (P&lt;0 .05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Homo sapiens	53-61
25449069-5	2014	LY294002 could reduce the phosphorylation of Akt and GSK3beta (P&lt; 0.01, P&lt; 0.05), and also decrease the DRD2 mRNA (P&lt;0 .05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	dopamine receptor D2	Homo sapiens	110-114
25344912-5	2014	Inhibition of the PI3K/AKT pathway with specific inhibitors, wortmannin and LY294002, significantly reduced Bcl-xL expression, induced caspase-3-dependent apoptosis, and repressed cell proliferation and tumor growth in vitro and in vivo without obvious toxic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	BCL2 like 1	Homo sapiens	108-114
25344912-5	2014	Inhibition of the PI3K/AKT pathway with specific inhibitors, wortmannin and LY294002, significantly reduced Bcl-xL expression, induced caspase-3-dependent apoptosis, and repressed cell proliferation and tumor growth in vitro and in vivo without obvious toxic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	caspase 3	Homo sapiens	135-144
25403445-10	2014	On the other hand, the PI3K inhibitor, LY294002, and mTOR inhibitor, rapamycin, inhibited the leptin-induced expression of GRP78.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	leptin	Homo sapiens	94-100
25628782-6	2014	However, IMA and LY294002 significantly inhibited the expression of PDGFR-beta and p-PI3K (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	platelet derived growth factor receptor beta	Rattus norvegicus	68-78
25685660-12	2015	Importantly, combination of TAM with inhibitors to PI3K inhibitor (LY294002) or PKCzeta resulted in secretion of Par-4 and cell death in MCS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	pro-apoptotic WT1 regulator	Homo sapiens	113-118
25271104-7	2014	Pretreatment with LY294002 (a PI3K/Akt inhibitor) suppressed the CA-induced phosphorylation of IkappaB kinase (IKK) and IkappaBalpha, p65 nuclear translocation, and nuclear factor-kappa B (NF-kappaB)-DNA binding activity as well as GSTP protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	glutathione S-transferase pi 1	Rattus norvegicus	232-236
25403445-10	2014	On the other hand, the PI3K inhibitor, LY294002, and mTOR inhibitor, rapamycin, inhibited the leptin-induced expression of GRP78.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	heat shock protein family A (Hsp70) member 5	Homo sapiens	123-128
25257463-10	2014	BBR can increase the level of PI3K/Akt/eNOS mRNA and the protein level of PI3K, p-Akt, eNOS and p-eNOS, which can be blocked by PI3K inhibitor (LY294002) and eNOS inhibitor (l-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	AKT serine/threonine kinase 1	Homo sapiens	35-38
25257463-10	2014	BBR can increase the level of PI3K/Akt/eNOS mRNA and the protein level of PI3K, p-Akt, eNOS and p-eNOS, which can be blocked by PI3K inhibitor (LY294002) and eNOS inhibitor (l-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	nitric oxide synthase 3	Homo sapiens	39-43
25257463-10	2014	BBR can increase the level of PI3K/Akt/eNOS mRNA and the protein level of PI3K, p-Akt, eNOS and p-eNOS, which can be blocked by PI3K inhibitor (LY294002) and eNOS inhibitor (l-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	AKT serine/threonine kinase 1	Homo sapiens	82-85
25257463-10	2014	BBR can increase the level of PI3K/Akt/eNOS mRNA and the protein level of PI3K, p-Akt, eNOS and p-eNOS, which can be blocked by PI3K inhibitor (LY294002) and eNOS inhibitor (l-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	nitric oxide synthase 3	Homo sapiens	87-91
25257463-10	2014	BBR can increase the level of PI3K/Akt/eNOS mRNA and the protein level of PI3K, p-Akt, eNOS and p-eNOS, which can be blocked by PI3K inhibitor (LY294002) and eNOS inhibitor (l-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	nitric oxide synthase 3	Homo sapiens	87-91
25257463-10	2014	BBR can increase the level of PI3K/Akt/eNOS mRNA and the protein level of PI3K, p-Akt, eNOS and p-eNOS, which can be blocked by PI3K inhibitor (LY294002) and eNOS inhibitor (l-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	nitric oxide synthase 3	Homo sapiens	87-91
25398131-8	2014	We further observed that LY294002, a PI3K inhibitor, could reverse CEACAM6-induced EMT via mesenchymal-epithelial transition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	CEA cell adhesion molecule 6	Homo sapiens	67-74
25391146-7	2014	Down-regulation of PI3K P85 levels by treatment with LY294002 (a PI3K inhibitor) led to suppression of P-eNOS and P-AKT expression levels, which in turn resulted in inhibition of RUNX2, OCN and ALP mRNA expression in osteoblasts induced by glimepiride at both glucose concentrations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	nitric oxide synthase 3	Rattus norvegicus	105-109
25391146-8	2014	ALP activity was partially inhibited by 10 microM LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	PDZ and LIM domain 3	Rattus norvegicus	0-3
25425962-5	2014	RESULTS: Our results demonstrate that treatment of LacZ+, GFAP + and PCNA + (12) V-Ras Tg transformed astrocytes with SF1126 and LY294002 blocked the activation of AKT as well as EGF-induced phospho-ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	glial fibrillary acidic protein	Mus musculus	58-62
25425962-5	2014	RESULTS: Our results demonstrate that treatment of LacZ+, GFAP + and PCNA + (12) V-Ras Tg transformed astrocytes with SF1126 and LY294002 blocked the activation of AKT as well as EGF-induced phospho-ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	thymoma viral proto-oncogene 1	Mus musculus	164-167
25386685-10	2014	The increased phosphorylation levels of PI3-K, Akt and JNK in 4% HCM were blocked by LY294002 and SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Rattus norvegicus	47-50
25386685-10	2014	The increased phosphorylation levels of PI3-K, Akt and JNK in 4% HCM were blocked by LY294002 and SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	mitogen-activated protein kinase 8	Rattus norvegicus	55-58
25391146-7	2014	Down-regulation of PI3K P85 levels by treatment with LY294002 (a PI3K inhibitor) led to suppression of P-eNOS and P-AKT expression levels, which in turn resulted in inhibition of RUNX2, OCN and ALP mRNA expression in osteoblasts induced by glimepiride at both glucose concentrations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
25391146-7	2014	Down-regulation of PI3K P85 levels by treatment with LY294002 (a PI3K inhibitor) led to suppression of P-eNOS and P-AKT expression levels, which in turn resulted in inhibition of RUNX2, OCN and ALP mRNA expression in osteoblasts induced by glimepiride at both glucose concentrations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	RUNX family transcription factor 2	Rattus norvegicus	179-184
25391146-7	2014	Down-regulation of PI3K P85 levels by treatment with LY294002 (a PI3K inhibitor) led to suppression of P-eNOS and P-AKT expression levels, which in turn resulted in inhibition of RUNX2, OCN and ALP mRNA expression in osteoblasts induced by glimepiride at both glucose concentrations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	PDZ and LIM domain 3	Rattus norvegicus	194-197
25489416-7	2014	Treatment of cells with a PI3K-specific inhibitor, LY294002, suppressed the HO-1 expression, Nrf2 DNA binding and ARE-mediated transcriptional activities in arctigenin-treated astrocyte cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	NFE2 like bZIP transcription factor 2	Rattus norvegicus	93-97
25382615-9	2014	Additionally, the PI3K/Akt inhibitor, LY294002, in treating MGC-803 cells potently suppressed cell invasion and migration as well as expression of MMP-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	23-26
25382615-9	2014	Additionally, the PI3K/Akt inhibitor, LY294002, in treating MGC-803 cells potently suppressed cell invasion and migration as well as expression of MMP-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	matrix metallopeptidase 9	Homo sapiens	147-152
25289059-4	2014	Hsp90 expression was increased 3.31-fold in VEGF-C treated HeLa cells, and this increase was attenuated in the treatment groups (2.17-, 1.69-, 1.82-fold in VEGF-C + KDR-Ab, VEGF-C + PD98059 and VEGF-C + LY294002, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
25289059-4	2014	Hsp90 expression was increased 3.31-fold in VEGF-C treated HeLa cells, and this increase was attenuated in the treatment groups (2.17-, 1.69-, 1.82-fold in VEGF-C + KDR-Ab, VEGF-C + PD98059 and VEGF-C + LY294002, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	vascular endothelial growth factor C	Homo sapiens	44-50
25289059-4	2014	Hsp90 expression was increased 3.31-fold in VEGF-C treated HeLa cells, and this increase was attenuated in the treatment groups (2.17-, 1.69-, 1.82-fold in VEGF-C + KDR-Ab, VEGF-C + PD98059 and VEGF-C + LY294002, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	vascular endothelial growth factor C	Homo sapiens	156-162
25172557-8	2014	Importantly, E2-induced Nrf2 activation was completely suppressed by the PI3K inhibitors LY294002 and Wortmannin while the GSK3beta inhibitor CT99021 upregulated Nrf2 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
25289059-4	2014	Hsp90 expression was increased 3.31-fold in VEGF-C treated HeLa cells, and this increase was attenuated in the treatment groups (2.17-, 1.69-, 1.82-fold in VEGF-C + KDR-Ab, VEGF-C + PD98059 and VEGF-C + LY294002, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	vascular endothelial growth factor C	Homo sapiens	156-162
25289059-4	2014	Hsp90 expression was increased 3.31-fold in VEGF-C treated HeLa cells, and this increase was attenuated in the treatment groups (2.17-, 1.69-, 1.82-fold in VEGF-C + KDR-Ab, VEGF-C + PD98059 and VEGF-C + LY294002, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	vascular endothelial growth factor C	Homo sapiens	156-162
25161157-10	2014	Administration of the inhibitors LY294002, perifosine, BAY11-7082, and SC-514 confirmed the roles of PI3K/Akt and NF-kappaB on the production of GM-CSF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	colony stimulating factor 2	Homo sapiens	145-151
25119993-8	2014	Moreover, IK inhibited the phosphorylation of AKT/mTOR protein and cell proliferation induced by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	46-49
25340291-6	2014	Moreover, LY294002, a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinases (PI3K), was selected to pretreat ovarian cancer cells to confirm whether PI3K/Akt signaling is involved in this event.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	179-182
25447788-7	2014	Furthermore, LY294002, the phosphoinositide 3-kinase (PI3-K) inhibitor, suppressed the effects of fenofibrate on BACE-1, sAPPbeta, and Abeta42, but not PPAR-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	27-52
25447788-7	2014	Furthermore, LY294002, the phosphoinositide 3-kinase (PI3-K) inhibitor, suppressed the effects of fenofibrate on BACE-1, sAPPbeta, and Abeta42, but not PPAR-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	beta-site APP cleaving enzyme 1	Mus musculus	113-119
25179784-7	2014	The elevated Akt/mTOR signaling was likely responsible for increased production of TNF-alpha protein at the translational level, as suppression of this pathway by LY294002, an inhibitor of the upstream phosphatidylinositol 3-kinase (PI3K), abrogated such an enhancement of TNF-alpha protein expression even though its mRNA levels were conversely increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	thymoma viral proto-oncogene 1	Mus musculus	13-16
25179784-7	2014	The elevated Akt/mTOR signaling was likely responsible for increased production of TNF-alpha protein at the translational level, as suppression of this pathway by LY294002, an inhibitor of the upstream phosphatidylinositol 3-kinase (PI3K), abrogated such an enhancement of TNF-alpha protein expression even though its mRNA levels were conversely increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	mechanistic target of rapamycin kinase	Mus musculus	17-21
25179784-7	2014	The elevated Akt/mTOR signaling was likely responsible for increased production of TNF-alpha protein at the translational level, as suppression of this pathway by LY294002, an inhibitor of the upstream phosphatidylinositol 3-kinase (PI3K), abrogated such an enhancement of TNF-alpha protein expression even though its mRNA levels were conversely increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	tumor necrosis factor	Mus musculus	83-92
25179784-7	2014	The elevated Akt/mTOR signaling was likely responsible for increased production of TNF-alpha protein at the translational level, as suppression of this pathway by LY294002, an inhibitor of the upstream phosphatidylinositol 3-kinase (PI3K), abrogated such an enhancement of TNF-alpha protein expression even though its mRNA levels were conversely increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	202-231
25179784-7	2014	The elevated Akt/mTOR signaling was likely responsible for increased production of TNF-alpha protein at the translational level, as suppression of this pathway by LY294002, an inhibitor of the upstream phosphatidylinositol 3-kinase (PI3K), abrogated such an enhancement of TNF-alpha protein expression even though its mRNA levels were conversely increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	tumor necrosis factor	Mus musculus	273-282
25119993-8	2014	Moreover, IK inhibited the phosphorylation of AKT/mTOR protein and cell proliferation induced by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	mechanistic target of rapamycin kinase	Homo sapiens	50-54
24939171-7	2014	H2 S-treated astrocytes increased VEGF and Ang-1 expression, and the inhibition of phosphatidylinositide 3-kinase (PI3K)/AKT signaling by LY294002 significantly reduced H2 S-induced VEGF and Ang-1 expression in astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	83-113
24939171-7	2014	H2 S-treated astrocytes increased VEGF and Ang-1 expression, and the inhibition of phosphatidylinositide 3-kinase (PI3K)/AKT signaling by LY294002 significantly reduced H2 S-induced VEGF and Ang-1 expression in astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	AKT serine/threonine kinase 1	Rattus norvegicus	121-124
25039425-6	2014	The increase in GM1 expression induced by leptin was inhibited after pre-treatment with inhibitors of phosphatidylinositol 3-kinase (LY294002), Akt (triciribine) and the mammalian target of rapamycin (i.e. rapamycin), but not by an inhibitor of extracellular signal-regulated kinase (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	leptin	Homo sapiens	42-48
24939171-7	2014	H2 S-treated astrocytes increased VEGF and Ang-1 expression, and the inhibition of phosphatidylinositide 3-kinase (PI3K)/AKT signaling by LY294002 significantly reduced H2 S-induced VEGF and Ang-1 expression in astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	vascular endothelial growth factor A	Rattus norvegicus	182-186
24939171-7	2014	H2 S-treated astrocytes increased VEGF and Ang-1 expression, and the inhibition of phosphatidylinositide 3-kinase (PI3K)/AKT signaling by LY294002 significantly reduced H2 S-induced VEGF and Ang-1 expression in astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	angiopoietin 1	Rattus norvegicus	191-196
25173404-7	2014	Interestingly, these effects of puerarin against Abeta insult were abolished by LY294002, an inhibitor of PI3K phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	amyloid beta (A4) precursor protein	Mus musculus	49-54
25216292-3	2014	The effects of estrogen and LY294002, a PI3K inhibitor, on the invasion of shRNA ER alpha/beta SKOV3 cells were evaluated in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	estrogen receptor 1	Homo sapiens	81-89
25216292-5	2014	When the PI3K/AKT pathway was suppressed by LY294002, the effect of estrogen was attenuated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	14-17
24977346-8	2014	Incubation with LY294002 or Akt inhibitor reduced PDE5 activity in porcine pulmonary arteries.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	phosphodiesterase 5A	Homo sapiens	50-54
25195717-7	2014	The effects of puerarin could be partially blocked by pharmacologic inhibition of PI3K and the glycogen synthase kinase 3beta (GSK-3beta) pathways with LY294002 and LiCl, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	glycogen synthase kinase 3 beta	Rattus norvegicus	95-125
25195717-7	2014	The effects of puerarin could be partially blocked by pharmacologic inhibition of PI3K and the glycogen synthase kinase 3beta (GSK-3beta) pathways with LY294002 and LiCl, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	glycogen synthase kinase 3 beta	Rattus norvegicus	127-136
25531381-5	2014	PTEN and AFP co-localized in the cytoplasm, and co-IP indicated that AFP interacts with PTEN in BEL-7402 cells.RNAi knockdown of AFP expression led to reduced growth of BEL-7402 cells.BEL-7402 cells transfected with AFP-short interfering (si)RNA vectors showed enhanced sensitivity to ATRA and reduced expression of pAKT(Ser473) and Src; Ly294002 reduced the role of AFP in stimulating expression of pAKT(Ser473) and Src.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	338-346	alpha fetoprotein	Homo sapiens	69-72
24989178-8	2014	Radiation-induced VEGF-C expression was down-regulated by LY294002 and rapamycin (both p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	vascular endothelial growth factor C	Homo sapiens	18-24
25374071-2	2014	METHODS: The HEK293 cells transfected stably with B7-H4, named B7-H4/HEK293, were treated with the PI3K/AKT specific inhibitor LY294002 and/or the nuclear export inhibitor leptomycin B (LMB).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	104-107
25374071-6	2014	Western blotting demonstrated that after the PI3K/AKT signal pathway was inhibited by LY294002 for 24 hours, the levels of B7-H4 in cell membrane and cytoplasm decreased significantly (P&lt;0.05), while the expression in nuclear increased significantly (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	thymoma viral proto-oncogene 1	Mus musculus	50-53
25228694-11	2014	More importantly, the palmitic acid-stimulated proliferation was further enhanced in the Akt-overexpressed melanoma cells and was reduced by LY294002 or knockdown of endogenous Akt or overexpression of Akt mutants.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	thymoma viral proto-oncogene 1	Mus musculus	89-92
25345853-10	2014	Furthermore, PI3K/Akt inhibitor LY294002 enhanced anti-metastatic potential of EEOS to attenuate the expression of uPA and MMP-9 in OPN treated NCI-H 460 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	18-21
25345853-10	2014	Furthermore, PI3K/Akt inhibitor LY294002 enhanced anti-metastatic potential of EEOS to attenuate the expression of uPA and MMP-9 in OPN treated NCI-H 460 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	plasminogen activator, urokinase	Homo sapiens	115-118
25345853-10	2014	Furthermore, PI3K/Akt inhibitor LY294002 enhanced anti-metastatic potential of EEOS to attenuate the expression of uPA and MMP-9 in OPN treated NCI-H 460 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	matrix metallopeptidase 9	Homo sapiens	123-128
25345853-10	2014	Furthermore, PI3K/Akt inhibitor LY294002 enhanced anti-metastatic potential of EEOS to attenuate the expression of uPA and MMP-9 in OPN treated NCI-H 460 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	secreted phosphoprotein 1	Homo sapiens	132-135
25142024-14	2014	LY294002, an Akt activation inhibitor, attenuated the isoflurane effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	13-16
25531381-5	2014	PTEN and AFP co-localized in the cytoplasm, and co-IP indicated that AFP interacts with PTEN in BEL-7402 cells.RNAi knockdown of AFP expression led to reduced growth of BEL-7402 cells.BEL-7402 cells transfected with AFP-short interfering (si)RNA vectors showed enhanced sensitivity to ATRA and reduced expression of pAKT(Ser473) and Src; Ly294002 reduced the role of AFP in stimulating expression of pAKT(Ser473) and Src.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	338-346	phosphatase and tensin homolog	Homo sapiens	88-92
25531381-5	2014	PTEN and AFP co-localized in the cytoplasm, and co-IP indicated that AFP interacts with PTEN in BEL-7402 cells.RNAi knockdown of AFP expression led to reduced growth of BEL-7402 cells.BEL-7402 cells transfected with AFP-short interfering (si)RNA vectors showed enhanced sensitivity to ATRA and reduced expression of pAKT(Ser473) and Src; Ly294002 reduced the role of AFP in stimulating expression of pAKT(Ser473) and Src.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	338-346	alpha fetoprotein	Homo sapiens	69-72
25531381-5	2014	PTEN and AFP co-localized in the cytoplasm, and co-IP indicated that AFP interacts with PTEN in BEL-7402 cells.RNAi knockdown of AFP expression led to reduced growth of BEL-7402 cells.BEL-7402 cells transfected with AFP-short interfering (si)RNA vectors showed enhanced sensitivity to ATRA and reduced expression of pAKT(Ser473) and Src; Ly294002 reduced the role of AFP in stimulating expression of pAKT(Ser473) and Src.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	338-346	alpha fetoprotein	Homo sapiens	69-72
25531381-5	2014	PTEN and AFP co-localized in the cytoplasm, and co-IP indicated that AFP interacts with PTEN in BEL-7402 cells.RNAi knockdown of AFP expression led to reduced growth of BEL-7402 cells.BEL-7402 cells transfected with AFP-short interfering (si)RNA vectors showed enhanced sensitivity to ATRA and reduced expression of pAKT(Ser473) and Src; Ly294002 reduced the role of AFP in stimulating expression of pAKT(Ser473) and Src.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	338-346	alpha fetoprotein	Homo sapiens	69-72
25419430-4	2014	These results indicated that IRS-4 was very likely to be involved in PI3K/Akt path way, which was further confirmed by the fact that the PI3K/Akt blocker LY294002 attenuated the proliferation and migration of the hepatoblastoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	insulin receptor substrate 4	Homo sapiens	29-34
25106857-3	2014	Through LY294002 suppressing targeted gene, the LY294002 treatment specifically and significantly knocked down the expressions of tumor TLR3 and PI3K proteins in cervical cancer mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	toll-like receptor 3	Mus musculus	136-140
25106857-3	2014	Through LY294002 suppressing targeted gene, the LY294002 treatment specifically and significantly knocked down the expressions of tumor TLR3 and PI3K proteins in cervical cancer mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	toll-like receptor 3	Mus musculus	136-140
25550859-4	2014	The effect of rhACE2 on phosphorylation eNOS level was also observed in the presence of LY294002 (10 mumol/L) (PI3K/AKT inhibitors).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	nitric oxide synthase 3	Homo sapiens	40-44
25550859-8	2014	After HUVEC was intervened by PI3K/AKT pathway inhibitor LY294002, the expression level of phosphorylated eNOS was significantly lower than that in the rhACE2 30 min treatment group (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	35-38
25419430-4	2014	These results indicated that IRS-4 was very likely to be involved in PI3K/Akt path way, which was further confirmed by the fact that the PI3K/Akt blocker LY294002 attenuated the proliferation and migration of the hepatoblastoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Homo sapiens	74-77
25550859-8	2014	After HUVEC was intervened by PI3K/AKT pathway inhibitor LY294002, the expression level of phosphorylated eNOS was significantly lower than that in the rhACE2 30 min treatment group (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	nitric oxide synthase 3	Homo sapiens	106-110
25419430-4	2014	These results indicated that IRS-4 was very likely to be involved in PI3K/Akt path way, which was further confirmed by the fact that the PI3K/Akt blocker LY294002 attenuated the proliferation and migration of the hepatoblastoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Homo sapiens	142-145
25550859-9	2014	rhACE2 may reduce the activity of Ang II inhibited endothelial cell eNOS, which can be blocked by PI3K/AKT pathway inhibitor LY294002, suggesting PI3K/AKT signaling pathway plays an important role in rhACE2"s promotion of the activity of endothelial cell eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	angiogenin	Homo sapiens	34-37
25550859-9	2014	rhACE2 may reduce the activity of Ang II inhibited endothelial cell eNOS, which can be blocked by PI3K/AKT pathway inhibitor LY294002, suggesting PI3K/AKT signaling pathway plays an important role in rhACE2"s promotion of the activity of endothelial cell eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	nitric oxide synthase 3	Homo sapiens	68-72
25550859-9	2014	rhACE2 may reduce the activity of Ang II inhibited endothelial cell eNOS, which can be blocked by PI3K/AKT pathway inhibitor LY294002, suggesting PI3K/AKT signaling pathway plays an important role in rhACE2"s promotion of the activity of endothelial cell eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	AKT serine/threonine kinase 1	Homo sapiens	103-106
25550859-9	2014	rhACE2 may reduce the activity of Ang II inhibited endothelial cell eNOS, which can be blocked by PI3K/AKT pathway inhibitor LY294002, suggesting PI3K/AKT signaling pathway plays an important role in rhACE2"s promotion of the activity of endothelial cell eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	AKT serine/threonine kinase 1	Homo sapiens	151-154
25550859-9	2014	rhACE2 may reduce the activity of Ang II inhibited endothelial cell eNOS, which can be blocked by PI3K/AKT pathway inhibitor LY294002, suggesting PI3K/AKT signaling pathway plays an important role in rhACE2"s promotion of the activity of endothelial cell eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	nitric oxide synthase 3	Homo sapiens	255-259
25036402-8	2014	Treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 could diminish Jab1 expression but increase BRSK1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	13-42
24939823-5	2014	Jaceosidin-induced proliferation and migration of human umbilical vascular endothelial cells were strongly inhibited by the phosphatidylinositol 3-kinase inhibitor LY294002 and NF-kappaB inhibitor BAY11-7082, indicating that the PI3K/AKT/NF-kappaB signaling pathway is involved in jaceosidin-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	AKT serine/threonine kinase 1	Homo sapiens	234-237
24939823-5	2014	Jaceosidin-induced proliferation and migration of human umbilical vascular endothelial cells were strongly inhibited by the phosphatidylinositol 3-kinase inhibitor LY294002 and NF-kappaB inhibitor BAY11-7082, indicating that the PI3K/AKT/NF-kappaB signaling pathway is involved in jaceosidin-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	nuclear factor kappa B subunit 1	Homo sapiens	238-247
25171655-9	2014	Moreover, pretreatment of bone marrow-derived macrophages with PI3K inhibitor (LY294002) activated Foxo1 signaling, which in turn enhanced TLR4-driven innate responses in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	forkhead box O1	Mus musculus	99-104
25171655-9	2014	Moreover, pretreatment of bone marrow-derived macrophages with PI3K inhibitor (LY294002) activated Foxo1 signaling, which in turn enhanced TLR4-driven innate responses in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	toll-like receptor 4	Mus musculus	139-143
24972386-7	2014	The pharmacological blockade of PI3K/Akt survival pathway by LY294002 fully inhibited in vitro and in vivo angiogenesis induced by mCRP/Notch-3/Fc combination while blocking Notch signalling by gamma-secretase inhibitor (DAPT) partially inhibited mCRP/Notch-3/Fc-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Bos taurus	37-40
24972386-7	2014	The pharmacological blockade of PI3K/Akt survival pathway by LY294002 fully inhibited in vitro and in vivo angiogenesis induced by mCRP/Notch-3/Fc combination while blocking Notch signalling by gamma-secretase inhibitor (DAPT) partially inhibited mCRP/Notch-3/Fc-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	C-reactive protein, pentraxin-related	Mus musculus	131-135
24972386-7	2014	The pharmacological blockade of PI3K/Akt survival pathway by LY294002 fully inhibited in vitro and in vivo angiogenesis induced by mCRP/Notch-3/Fc combination while blocking Notch signalling by gamma-secretase inhibitor (DAPT) partially inhibited mCRP/Notch-3/Fc-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	notch receptor 3	Bos taurus	136-143
24972386-7	2014	The pharmacological blockade of PI3K/Akt survival pathway by LY294002 fully inhibited in vitro and in vivo angiogenesis induced by mCRP/Notch-3/Fc combination while blocking Notch signalling by gamma-secretase inhibitor (DAPT) partially inhibited mCRP/Notch-3/Fc-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	notch receptor 3	Bos taurus	136-141
24972386-7	2014	The pharmacological blockade of PI3K/Akt survival pathway by LY294002 fully inhibited in vitro and in vivo angiogenesis induced by mCRP/Notch-3/Fc combination while blocking Notch signalling by gamma-secretase inhibitor (DAPT) partially inhibited mCRP/Notch-3/Fc-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	C-reactive protein, pentraxin-related	Mus musculus	247-251
24972386-7	2014	The pharmacological blockade of PI3K/Akt survival pathway by LY294002 fully inhibited in vitro and in vivo angiogenesis induced by mCRP/Notch-3/Fc combination while blocking Notch signalling by gamma-secretase inhibitor (DAPT) partially inhibited mCRP/Notch-3/Fc-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	notch receptor 3	Bos taurus	252-259
25128810-6	2014	The effects of hispidin on Akt and ERK phosphorylation were abrogated by LY294002 (a PI3K/Akt inhibitor) and U0126 (an ERK1/2 inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Rattus norvegicus	27-30
25128810-6	2014	The effects of hispidin on Akt and ERK phosphorylation were abrogated by LY294002 (a PI3K/Akt inhibitor) and U0126 (an ERK1/2 inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Rattus norvegicus	90-93
25036402-8	2014	Treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 could diminish Jab1 expression but increase BRSK1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	COP9 signalosome subunit 5	Homo sapiens	84-88
25128810-7	2014	The effect of hispidin on GSK-3b activities was also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	glycogen synthase kinase 3 beta	Rattus norvegicus	26-32
25036402-8	2014	Treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 could diminish Jab1 expression but increase BRSK1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	BR serine/threonine kinase 1	Homo sapiens	113-118
25066549-2	2014	Treatment of RAW264.7 cells with DL increased HO-1 expression in a time- and concentration-dependent manner, and this up-regulation of HO-1 by DL was significantly inhibited by silencing either Nrf2 and p38 or treating cells with SB203580 (a p38MAPK inhibitor), but it was not inhibited in the presence of SP600125 (an ERK inhibitor), PD98059 (a JNK inhibitor), or LY294002 (PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	365-373	nuclear factor, erythroid derived 2, like 2	Mus musculus	194-198
24770666-6	2014	Inhibition of PI3K/Akt pathway by LY294002 reversed the EMT transition in breast cancer cell lines MCF-7 and BT-20 induced by IL-7delta5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	19-22
24771072-12	2014	Administration of LY294002 abolished the effects of BNP postconditioning on myocardial I/R injury and the expressions of phospho-Akt and HMGB1 (all p&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	natriuretic peptide B	Rattus norvegicus	52-55
24771072-12	2014	Administration of LY294002 abolished the effects of BNP postconditioning on myocardial I/R injury and the expressions of phospho-Akt and HMGB1 (all p&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	129-132
24771072-12	2014	Administration of LY294002 abolished the effects of BNP postconditioning on myocardial I/R injury and the expressions of phospho-Akt and HMGB1 (all p&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	high mobility group box 1	Rattus norvegicus	137-142
25066549-2	2014	Treatment of RAW264.7 cells with DL increased HO-1 expression in a time- and concentration-dependent manner, and this up-regulation of HO-1 by DL was significantly inhibited by silencing either Nrf2 and p38 or treating cells with SB203580 (a p38MAPK inhibitor), but it was not inhibited in the presence of SP600125 (an ERK inhibitor), PD98059 (a JNK inhibitor), or LY294002 (PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	365-373	mitogen-activated protein kinase 14	Mus musculus	203-206
25192050-7	2014	LY294002 and SB203580 decreased the expression of HIF-1alpha and VEGF after HPC, whereas U0126 increased HIF-1alpha and VEGF after tGCI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	50-60
25192050-7	2014	LY294002 and SB203580 decreased the expression of HIF-1alpha and VEGF after HPC, whereas U0126 increased HIF-1alpha and VEGF after tGCI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	vascular endothelial growth factor A	Rattus norvegicus	65-69
25078983-5	2014	LY294002 was applied to inhibit PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	37-40
25078983-8	2014	LY294002 pre-treatment significantly alleviated Ang II-induced HUVEC senescence, and partly reversed the elevation of TERT, UCP2, p-Akt, c-myc and p53 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	angiotensinogen	Homo sapiens	48-54
25078983-8	2014	LY294002 pre-treatment significantly alleviated Ang II-induced HUVEC senescence, and partly reversed the elevation of TERT, UCP2, p-Akt, c-myc and p53 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	telomerase reverse transcriptase	Homo sapiens	118-122
25109283-9	2014	Blockade of the PIK3/Akt channel by LY294002 eliminated the protective effects of proanthocyanidins and induced a significant decrease in p-Akt protein and p-GSK-3beta expression levels as compared with the PC group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Rattus norvegicus	21-24
25078983-8	2014	LY294002 pre-treatment significantly alleviated Ang II-induced HUVEC senescence, and partly reversed the elevation of TERT, UCP2, p-Akt, c-myc and p53 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	uncoupling protein 2	Homo sapiens	124-128
25109283-9	2014	Blockade of the PIK3/Akt channel by LY294002 eliminated the protective effects of proanthocyanidins and induced a significant decrease in p-Akt protein and p-GSK-3beta expression levels as compared with the PC group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Rattus norvegicus	140-143
25109283-9	2014	Blockade of the PIK3/Akt channel by LY294002 eliminated the protective effects of proanthocyanidins and induced a significant decrease in p-Akt protein and p-GSK-3beta expression levels as compared with the PC group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	glycogen synthase kinase 3 beta	Rattus norvegicus	158-167
25078983-8	2014	LY294002 pre-treatment significantly alleviated Ang II-induced HUVEC senescence, and partly reversed the elevation of TERT, UCP2, p-Akt, c-myc and p53 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	132-135
25078983-8	2014	LY294002 pre-treatment significantly alleviated Ang II-induced HUVEC senescence, and partly reversed the elevation of TERT, UCP2, p-Akt, c-myc and p53 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	137-142
25078983-8	2014	LY294002 pre-treatment significantly alleviated Ang II-induced HUVEC senescence, and partly reversed the elevation of TERT, UCP2, p-Akt, c-myc and p53 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor protein p53	Homo sapiens	147-150
25237049-5	2014	In cultured EPCs, kallistatin significantly reduced tumor necrosis factor-alpha-induced apoptosis and caspase-3 activity, but kallistatin"s effects were blocked by phosphoinositide 3-kinase inhibitor (LY294002) and nitric oxide (NO) synthase inhibitor (l-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	serine (or cysteine) proteinase inhibitor, clade A, member 3C	Rattus norvegicus	18-29
25027404-8	2014	By using the PI3K/Akt inhibitor LY294002, we further demonstrated that NC-induced apoptosis might be Akt-specific or dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	18-21
25027404-8	2014	By using the PI3K/Akt inhibitor LY294002, we further demonstrated that NC-induced apoptosis might be Akt-specific or dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	101-104
25268131-12	2014	The inhibitory effect of U-II on DOX-increased apoptosis was attenuated by inhibitors of ERK (U0126) and PI3K/Akt (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	urotensin 2	Homo sapiens	25-29
25345931-4	2014	The changes in the expressions of p-Akt in the cells were analyzed by Western blotting and qPCR in response to exendin-4 (10 nm/L) with or without exposure to PI3K/Akt inhibitor LY-294002 (50 nm/L); bFGF, VEGF, HGF, and IGF-1 production in the cells were detected using ELISA kits.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-187	AKT serine/threonine kinase 1	Rattus norvegicus	164-167
25146167-8	2014	Treatment of the human meningioma cell line HBL-52 with the PI3K inhibitor LY294002 resulted in reduction of p-AKT, p-p70S6K and p-ERK1/2 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	AKT serine/threonine kinase 1	Homo sapiens	111-114
25146167-8	2014	Treatment of the human meningioma cell line HBL-52 with the PI3K inhibitor LY294002 resulted in reduction of p-AKT, p-p70S6K and p-ERK1/2 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	ribosomal protein S6 kinase B1	Homo sapiens	118-124
25146167-8	2014	Treatment of the human meningioma cell line HBL-52 with the PI3K inhibitor LY294002 resulted in reduction of p-AKT, p-p70S6K and p-ERK1/2 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	mitogen-activated protein kinase 3	Homo sapiens	131-137
25237049-5	2014	In cultured EPCs, kallistatin significantly reduced tumor necrosis factor-alpha-induced apoptosis and caspase-3 activity, but kallistatin"s effects were blocked by phosphoinositide 3-kinase inhibitor (LY294002) and nitric oxide (NO) synthase inhibitor (l-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	tumor necrosis factor	Rattus norvegicus	52-79
25237049-5	2014	In cultured EPCs, kallistatin significantly reduced tumor necrosis factor-alpha-induced apoptosis and caspase-3 activity, but kallistatin"s effects were blocked by phosphoinositide 3-kinase inhibitor (LY294002) and nitric oxide (NO) synthase inhibitor (l-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	caspase 3	Rattus norvegicus	102-111
25223735-5	2014	The undifferentiated cell phenotype could be reversed by LY294002, which is an inhibitor of the PI3K/AKT signaling pathway, and this reversal was accompanied by a significant reduction in CSC phenotypic markers and functional properties.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	101-104
25237049-5	2014	In cultured EPCs, kallistatin significantly reduced tumor necrosis factor-alpha-induced apoptosis and caspase-3 activity, but kallistatin"s effects were blocked by phosphoinositide 3-kinase inhibitor (LY294002) and nitric oxide (NO) synthase inhibitor (l-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	serine (or cysteine) proteinase inhibitor, clade A, member 3C	Rattus norvegicus	126-137
25237049-6	2014	Kallistatin stimulated the proliferation, migration, adhesion and tube formation of EPCs; however, kallistatin"s actions were abolished by LY294002, l-NAME, endothelial NO synthase-small interfering RNA, constitutively active glycogen synthase kinase-3beta, or vascular endothelial growth factor antibody.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	serine (or cysteine) proteinase inhibitor, clade A, member 3C	Rattus norvegicus	99-110
25237049-8	2014	Kallistatin"s actions on phosphoinositide 3-kinase-Akt signaling were blocked by LY294002, l-NAME, and anti-vascular endothelial growth factor antibody.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	serine (or cysteine) proteinase inhibitor, clade A, member 3C	Rattus norvegicus	0-11
25237049-8	2014	Kallistatin"s actions on phosphoinositide 3-kinase-Akt signaling were blocked by LY294002, l-NAME, and anti-vascular endothelial growth factor antibody.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Rattus norvegicus	51-54
24995704-7	2014	Immunoblotting and immunohistochemical analysis showed that the microinjection of LY294002 (0.6 pmol) or PD98059 (3.0 pmol) into the NTS attenuated the IGF-1-induced depressor effects and Akt or ERK phosphorylation in WKY rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	insulin-like growth factor 1	Rattus norvegicus	152-157
25212780-12	2014	Specificity of PEDF"s activity was confirmed using the pharmacological inhibitors LY294002, SH6, and U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	serpin family F member 1	Homo sapiens	15-19
25152024-9	2014	Furthermore, pretreatment with JNK inhibitor SP600125 and p38 inhibitor SB203580, or with AKT inhibitor LY294002 abolished the effects of mig-2 on cisplaxtin-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	AKT serine/threonine kinase 1	Homo sapiens	90-93
25374590-8	2014	LY294002 resulted in an elevated expression of phosphorylated type I microtubule-associated protein 1B, whereas U0126 caused a reduction in expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	microtubule-associated protein 1B	Oryctolagus cuniculus	69-102
25181477-4	2014	Interestingly, the CCC treatment of the 3T3-L1 adipocytes suppressed the insulin-stimulated Akt and GSK3beta phosphorylation, and these effects were stronger in the presence of an inhibitor of Akt phosphorylation, LY294002, suggesting that CCC inhibited adipocyte differentiation through the down-regulation of Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	thymoma viral proto-oncogene 1	Mus musculus	193-196
25181477-4	2014	Interestingly, the CCC treatment of the 3T3-L1 adipocytes suppressed the insulin-stimulated Akt and GSK3beta phosphorylation, and these effects were stronger in the presence of an inhibitor of Akt phosphorylation, LY294002, suggesting that CCC inhibited adipocyte differentiation through the down-regulation of Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	thymoma viral proto-oncogene 1	Mus musculus	193-196
25183503-4	2014	Our studies showed that exposure to PD98059, TPCA-1 and LY294002 resulted in a dose-dependent reduction in the expression of mature miR-146a while the primary miR-146a expression was not changed by any inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	microRNA 146a	Homo sapiens	132-140
25183503-4	2014	Our studies showed that exposure to PD98059, TPCA-1 and LY294002 resulted in a dose-dependent reduction in the expression of mature miR-146a while the primary miR-146a expression was not changed by any inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	microRNA 146a	Homo sapiens	159-167
24995704-7	2014	Immunoblotting and immunohistochemical analysis showed that the microinjection of LY294002 (0.6 pmol) or PD98059 (3.0 pmol) into the NTS attenuated the IGF-1-induced depressor effects and Akt or ERK phosphorylation in WKY rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Rattus norvegicus	188-191
24995704-7	2014	Immunoblotting and immunohistochemical analysis showed that the microinjection of LY294002 (0.6 pmol) or PD98059 (3.0 pmol) into the NTS attenuated the IGF-1-induced depressor effects and Akt or ERK phosphorylation in WKY rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	Eph receptor B1	Rattus norvegicus	195-198
25068805-11	2014	Inhibition of AKT in Ishikawa cells with LY294002 resulted in a significant reduction in the levels of phospho-ERK1/2, whereas inhibition of ERK1/2 with PD98059 exerted no effects on AKT activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	14-17
24953795-6	2014	Blocking the PI3K/Akt pathway by its specific inhibitor LY294002 or Akt short hairpin RNA (shRNA) resulted in the reduced MDR of HL60/ADR cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	18-21
25212816-7	2014	When LY294002 was applied along with RA, collinear expression induced by RA was delayed, suggesting that the PI3K/Akt signaling pathway somehow regulates RA-induced collinear expression of Hox genes in F9 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	thymoma viral proto-oncogene 1	Mus musculus	114-117
25168152-7	2014	TSS also downregulated TNF-alpha-induced phosphorylation of phosphatidyl-inositol 3 kinase (PI3K) and Akt, and a selective PI3K/Akt inhibitor, LY294002, diminished TNF-alpha-induced NF-kappaB activation followed by levels of MMP-9, suggesting that TSS also reduces MMP-9 expression by inhibiting the PI3K/Akt-mediated NF-kappaB pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	tumor necrosis factor	Homo sapiens	23-32
25152024-9	2014	Furthermore, pretreatment with JNK inhibitor SP600125 and p38 inhibitor SB203580, or with AKT inhibitor LY294002 abolished the effects of mig-2 on cisplaxtin-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	FERM domain containing kindlin 2	Homo sapiens	138-143
24956021-7	2014	The addition of LY294002 decreased the p-AKT level, NOS activity, eNOS expression and NO production significantly, but had no significant effect on iNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
25068805-11	2014	Inhibition of AKT in Ishikawa cells with LY294002 resulted in a significant reduction in the levels of phospho-ERK1/2, whereas inhibition of ERK1/2 with PD98059 exerted no effects on AKT activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	mitogen-activated protein kinase 3	Homo sapiens	111-117
24132578-8	2014	APN neutralization antibody and LY294002 blocked the APN-mediated effects via inhibition of activated AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	adiponectin, C1Q and collagen domain containing	Homo sapiens	53-56
25257523-9	2014	LY294002 not only mitigated the up-regulated protein level of phosphor Akt at Ser473 caused by GRb1, but also reversed the inhibitory effect of GRb1 on OGD and transient ischemia-induced elevation in protein levels of LC3II and Beclin1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	71-74
25257523-9	2014	LY294002 not only mitigated the up-regulated protein level of phosphor Akt at Ser473 caused by GRb1, but also reversed the inhibitory effect of GRb1 on OGD and transient ischemia-induced elevation in protein levels of LC3II and Beclin1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	beclin 1	Homo sapiens	228-235
24132578-8	2014	APN neutralization antibody and LY294002 blocked the APN-mediated effects via inhibition of activated AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	102-105
24563226-6	2014	Moreover, infusion (5 mM) of GSK3beta activator LY294002 into DG abolished the antidepressant-like actions of butyrolactone and roscovitine, suggesting that inhibition of GSK3beta might be involved in the antidepressant effect of Cdk5 inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	glycogen synthase kinase 3 beta	Rattus norvegicus	29-37
24563226-6	2014	Moreover, infusion (5 mM) of GSK3beta activator LY294002 into DG abolished the antidepressant-like actions of butyrolactone and roscovitine, suggesting that inhibition of GSK3beta might be involved in the antidepressant effect of Cdk5 inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	glycogen synthase kinase 3 beta	Rattus norvegicus	171-179
24563226-6	2014	Moreover, infusion (5 mM) of GSK3beta activator LY294002 into DG abolished the antidepressant-like actions of butyrolactone and roscovitine, suggesting that inhibition of GSK3beta might be involved in the antidepressant effect of Cdk5 inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	cyclin-dependent kinase 5	Rattus norvegicus	230-234
24563226-9	2014	In contrast, pretreatment of LY294002 prevented the inhibitory effects of butyrolactone and roscovitine on GSK3beta activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	glycogen synthase kinase 3 beta	Rattus norvegicus	107-115
24951966-12	2014	Both PI3K inhibitor LY294002 (10 muM) and Akt inhibitor perifosine (10muM) were able to reverse the increases of CSE mRNA and H2S production in fluvastatin-stimulated macrophages.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	latexin	Homo sapiens	33-36
25245523-6	2014	Interestingly, ectopic overexpression of MTA1-induced CSCs properties and CDDP resistance were reversed in CNE1 cells after inhibition of PI3K/Akt by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	metastasis associated 1	Homo sapiens	41-45
25245523-6	2014	Interestingly, ectopic overexpression of MTA1-induced CSCs properties and CDDP resistance were reversed in CNE1 cells after inhibition of PI3K/Akt by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	AKT serine/threonine kinase 1	Homo sapiens	143-146
24878511-7	2014	Medulla infusion of the PI3K inhibitor, LY294002, prevents the SCI-induced Akt and FKHR phosphorylations and activates one of its death-promoting downstream targets, Fas ligand.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Rattus norvegicus	75-78
24878511-7	2014	Medulla infusion of the PI3K inhibitor, LY294002, prevents the SCI-induced Akt and FKHR phosphorylations and activates one of its death-promoting downstream targets, Fas ligand.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	forkhead box O1	Rattus norvegicus	83-87
24878511-7	2014	Medulla infusion of the PI3K inhibitor, LY294002, prevents the SCI-induced Akt and FKHR phosphorylations and activates one of its death-promoting downstream targets, Fas ligand.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	Fas ligand	Rattus norvegicus	166-176
24167160-12	2014	Hypoxic induction of CAT, AKT inhibition (LY294002), or addition of PEG-catalase partly ameliorated the H(2)O(2) -mediated loss of nuclear FoxO1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	forkhead box O1	Homo sapiens	139-144
24951966-12	2014	Both PI3K inhibitor LY294002 (10 muM) and Akt inhibitor perifosine (10muM) were able to reverse the increases of CSE mRNA and H2S production in fluvastatin-stimulated macrophages.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	cystathionine gamma-lyase	Homo sapiens	113-116
25086360-7	2014	LY294002 significantly abolished the effects of exogenous CCL19.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-C motif chemokine ligand 19	Homo sapiens	58-63
25118938-5	2014	Inhibition of p53 activity with pifithrin-alpha or inhibition of PI3K with LY294002 suppressed CdCl2-induced cellular damage and elevation of Notch1-NICD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	notch receptor 1	Homo sapiens	142-148
25157276-6	2014	Inhibition of PI3K by LY294002 decreased the level of p-AKT1 and activated FOXO1 transcription factor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Homo sapiens	56-60
25157276-6	2014	Inhibition of PI3K by LY294002 decreased the level of p-AKT1 and activated FOXO1 transcription factor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	forkhead box O1	Homo sapiens	75-80
25118938-9	2014	Furthermore, treatment with SB216763, an inhibitor of glycogen synthase kinase-3, suppressed the potency of LY294002 treatment to reduce Snail expression in HK-2 cells exposed to CdCl2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	snail family transcriptional repressor 1	Homo sapiens	137-142
24966188-6	2014	APJ shRNA pGPU6/Neo-rat-399, PI3K inhibitor LY294002, Akt inhibitor 1701-1 blocked the up-regulation of APJ, PI3K phosphorylation, Akt phosphorylation, LC3-II/I and beclin-1 expression, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	apelin receptor	Rattus norvegicus	0-3
25063033-6	2014	Significantly, Nrf2 shRNA knockdown or Akt inhibitors (LY 294002 and wortmannin) not only prevented salidroside-induced HO-1/NQO-1 transcription, but also alleviated salidroside-mediated cytoprotective effect against OGD/re-oxygenation in H9c2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-64	AKT serine/threonine kinase 1	Rattus norvegicus	39-42
25063033-6	2014	Significantly, Nrf2 shRNA knockdown or Akt inhibitors (LY 294002 and wortmannin) not only prevented salidroside-induced HO-1/NQO-1 transcription, but also alleviated salidroside-mediated cytoprotective effect against OGD/re-oxygenation in H9c2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-64	heme oxygenase 1	Rattus norvegicus	120-124
25063033-6	2014	Significantly, Nrf2 shRNA knockdown or Akt inhibitors (LY 294002 and wortmannin) not only prevented salidroside-induced HO-1/NQO-1 transcription, but also alleviated salidroside-mediated cytoprotective effect against OGD/re-oxygenation in H9c2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-64	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	125-130
25110865-9	2014	These effects were reversed by PI3K/AKT inhibitors (LY294002 and wortmannin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Rattus norvegicus	36-39
24953974-4	2014	Pharmacological inhibition of AMPK by Compound C suppressed the glabridin-induced glucose uptake, whereas phosphoinositide 3-kinase and Akt inhibition by LY294002 and Akt1/2 inhibitor, respectively, did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	thymoma viral proto-oncogene 1	Mus musculus	136-139
24966188-6	2014	APJ shRNA pGPU6/Neo-rat-399, PI3K inhibitor LY294002, Akt inhibitor 1701-1 blocked the up-regulation of APJ, PI3K phosphorylation, Akt phosphorylation, LC3-II/I and beclin-1 expression, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	apelin receptor	Rattus norvegicus	104-107
24966188-6	2014	APJ shRNA pGPU6/Neo-rat-399, PI3K inhibitor LY294002, Akt inhibitor 1701-1 blocked the up-regulation of APJ, PI3K phosphorylation, Akt phosphorylation, LC3-II/I and beclin-1 expression, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Rattus norvegicus	131-134
24966188-6	2014	APJ shRNA pGPU6/Neo-rat-399, PI3K inhibitor LY294002, Akt inhibitor 1701-1 blocked the up-regulation of APJ, PI3K phosphorylation, Akt phosphorylation, LC3-II/I and beclin-1 expression, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	beclin 1	Rattus norvegicus	165-173
24506791-6	2014	In addition, we established that thrombin stimulated the phosphorylation of c-Src, PDGFR, Akt and p65, which were inhibited by pre-treatment with their respective inhibitors PP1, AG1296, LY294002 or Bay11-7082.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	AKT serine/threonine kinase 1	Homo sapiens	90-93
24768640-10	2014	After an intracerebroventricular injection of LY294002 (inhibitor of PI3K/Akt, 10 muL, 100 nmol in 25% DMSO in PBS), the above effects of NaHS were attenuated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
25051885-7	2014	In addition, inhibitors of ERK1/2 (PD98059), p38 MAPK (SB203580), and PI3Kinase (LY294002) reversed PTHrP response in Caco-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	parathyroid hormone like hormone	Homo sapiens	100-105
25085593-7	2014	Moreover, both ZJW and a PI3K specific inhibitor (LY294002) suppressed phosphorylation of Akt (Ser473) and NF-kappaB, which is necessary in the activation of the PI3K/Akt/NF-kappaB pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	90-93
25085593-7	2014	Moreover, both ZJW and a PI3K specific inhibitor (LY294002) suppressed phosphorylation of Akt (Ser473) and NF-kappaB, which is necessary in the activation of the PI3K/Akt/NF-kappaB pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	nuclear factor kappa B subunit 1	Homo sapiens	107-116
25085593-7	2014	Moreover, both ZJW and a PI3K specific inhibitor (LY294002) suppressed phosphorylation of Akt (Ser473) and NF-kappaB, which is necessary in the activation of the PI3K/Akt/NF-kappaB pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	167-170
25085593-7	2014	Moreover, both ZJW and a PI3K specific inhibitor (LY294002) suppressed phosphorylation of Akt (Ser473) and NF-kappaB, which is necessary in the activation of the PI3K/Akt/NF-kappaB pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	nuclear factor kappa B subunit 1	Homo sapiens	171-180
24974736-7	2014	Sunitinib or LY294002, but not erlotinib, significantly inhibited the platelet-induced proliferation of osteosarcoma cells, indicating that PDGF released from platelets plays an important role in the proliferation of osteosarcomas by activating the PDGFR and then Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	platelet derived growth factor receptor beta	Homo sapiens	249-254
24974736-7	2014	Sunitinib or LY294002, but not erlotinib, significantly inhibited the platelet-induced proliferation of osteosarcoma cells, indicating that PDGF released from platelets plays an important role in the proliferation of osteosarcomas by activating the PDGFR and then Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	264-267
24506791-6	2014	In addition, we established that thrombin stimulated the phosphorylation of c-Src, PDGFR, Akt and p65, which were inhibited by pre-treatment with their respective inhibitors PP1, AG1296, LY294002 or Bay11-7082.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	coagulation factor II, thrombin	Homo sapiens	33-41
24506791-6	2014	In addition, we established that thrombin stimulated the phosphorylation of c-Src, PDGFR, Akt and p65, which were inhibited by pre-treatment with their respective inhibitors PP1, AG1296, LY294002 or Bay11-7082.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	76-81
24506791-6	2014	In addition, we established that thrombin stimulated the phosphorylation of c-Src, PDGFR, Akt and p65, which were inhibited by pre-treatment with their respective inhibitors PP1, AG1296, LY294002 or Bay11-7082.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	platelet derived growth factor receptor beta	Homo sapiens	83-88
24779362-9	2014	Functional expression of TRPV4 channels caused a sustained increase of [Ca(2+) ]i , inhibited by HC067047, bafetinib and wortmannin; but not by thapsigargin, UBO-QIC, dasatinib or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	transient receptor potential cation channel subfamily V member 4	Homo sapiens	25-30
24506791-6	2014	In addition, we established that thrombin stimulated the phosphorylation of c-Src, PDGFR, Akt and p65, which were inhibited by pre-treatment with their respective inhibitors PP1, AG1296, LY294002 or Bay11-7082.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	RELA proto-oncogene, NF-kB subunit	Homo sapiens	98-101
24506791-7	2014	In addition, thrombin also enhanced Akt and NF-kappaB translocation from the cytosol to the nucleus, which was reduced by PP1, AG1296 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	coagulation factor II, thrombin	Homo sapiens	13-21
24506791-7	2014	In addition, thrombin also enhanced Akt and NF-kappaB translocation from the cytosol to the nucleus, which was reduced by PP1, AG1296 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	AKT serine/threonine kinase 1	Homo sapiens	36-39
24506791-7	2014	In addition, thrombin also enhanced Akt and NF-kappaB translocation from the cytosol to the nucleus, which was reduced by PP1, AG1296 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	nuclear factor kappa B subunit 1	Homo sapiens	44-53
24506791-8	2014	Thrombin induced NF-kappaB promoter activity and the formation of the p65-Akt-p300 complex, which were inhibited by AG1296, LY294002 or PP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	coagulation factor II, thrombin	Homo sapiens	0-8
24506791-8	2014	Thrombin induced NF-kappaB promoter activity and the formation of the p65-Akt-p300 complex, which were inhibited by AG1296, LY294002 or PP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	nuclear factor kappa B subunit 1	Homo sapiens	17-26
24506791-8	2014	Thrombin induced NF-kappaB promoter activity and the formation of the p65-Akt-p300 complex, which were inhibited by AG1296, LY294002 or PP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	RELA proto-oncogene, NF-kB subunit	Homo sapiens	70-73
24506791-8	2014	Thrombin induced NF-kappaB promoter activity and the formation of the p65-Akt-p300 complex, which were inhibited by AG1296, LY294002 or PP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	AKT serine/threonine kinase 1	Homo sapiens	74-77
24506791-8	2014	Thrombin induced NF-kappaB promoter activity and the formation of the p65-Akt-p300 complex, which were inhibited by AG1296, LY294002 or PP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	E1A binding protein p300	Homo sapiens	78-82
24748323-7	2014	The observed promoting effect was significantly inhibited by the administration of the PI3K/AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	thymoma viral proto-oncogene 1	Mus musculus	92-95
23837575-7	2014	Blocking the PI3K/Akt cascade with a PI3K inhibitor LY294002 (10 muM) increased the cytotoxic effect of vincristine and doxorubicin on SK-OV-3 cell line.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	18-21
24488601-6	2014	Pharmacological inhibition of mitogen-activated protein kinase 1 (ERK1/2), CaMKII, and Trk (with U0126, KN93, or K252a, respectively) partially attenuated the stimulatory effect of DISS on phospho-CREB and BDNF expression; however, it was not inhibited by pharmacological inhibition of PKA or PI3K (with H89 and LY294002, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	312-320	mitogen-activated protein kinase 3	Homo sapiens	66-72
24488601-6	2014	Pharmacological inhibition of mitogen-activated protein kinase 1 (ERK1/2), CaMKII, and Trk (with U0126, KN93, or K252a, respectively) partially attenuated the stimulatory effect of DISS on phospho-CREB and BDNF expression; however, it was not inhibited by pharmacological inhibition of PKA or PI3K (with H89 and LY294002, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	312-320	neurotrophic receptor tyrosine kinase 1	Homo sapiens	87-90
24347388-7	2014	After treated with LY294002, high glucose-induced HKC cells showed decreased phospho-PRAS40-Thr246, phospho-Akt-Ser473, and SREBP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT1 substrate 1	Rattus norvegicus	85-91
24347388-7	2014	After treated with LY294002, high glucose-induced HKC cells showed decreased phospho-PRAS40-Thr246, phospho-Akt-Ser473, and SREBP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Rattus norvegicus	108-111
24347388-7	2014	After treated with LY294002, high glucose-induced HKC cells showed decreased phospho-PRAS40-Thr246, phospho-Akt-Ser473, and SREBP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	sterol regulatory element binding transcription factor 1	Rattus norvegicus	124-131
24816639-7	2014	Similarly, treatment with LY294002, an inhibitor of the PI3K/AKT pathway, inhibited the migration and invasion of RA-FLS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	61-64
24816639-9	2014	In addition, knockdown of SPHK1 or treatment with LY294002 inhibited the secretion of MMP-2 and MMP-9, and both synergistically reduced the production of MMP-2 and MMP-9 in RA-FLS in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	matrix metallopeptidase 2	Homo sapiens	86-91
25058399-10	2014	LY294002, a PI3K inhibitor, inhibited HPV-16 oncoprotein-induced activation of Akt, P70S6K, and P85S6K, expression of HIF-1alpha, VEGF, and IL-8, and in vitro angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	79-82
24816639-9	2014	In addition, knockdown of SPHK1 or treatment with LY294002 inhibited the secretion of MMP-2 and MMP-9, and both synergistically reduced the production of MMP-2 and MMP-9 in RA-FLS in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	matrix metallopeptidase 9	Homo sapiens	96-101
24816639-9	2014	In addition, knockdown of SPHK1 or treatment with LY294002 inhibited the secretion of MMP-2 and MMP-9, and both synergistically reduced the production of MMP-2 and MMP-9 in RA-FLS in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	matrix metallopeptidase 2	Homo sapiens	154-159
24816639-9	2014	In addition, knockdown of SPHK1 or treatment with LY294002 inhibited the secretion of MMP-2 and MMP-9, and both synergistically reduced the production of MMP-2 and MMP-9 in RA-FLS in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	matrix metallopeptidase 9	Homo sapiens	164-169
24838617-7	2014	Using the potent PI3K/Akt inhibitor, LY294002, we explored the likely mechanism of HMGB1-induced NS/PC proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	22-25
24838617-7	2014	Using the potent PI3K/Akt inhibitor, LY294002, we explored the likely mechanism of HMGB1-induced NS/PC proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	high mobility group box 1	Homo sapiens	83-88
24838617-10	2014	LY294002 effectively reduced phospho-Akt levels and reduced NS/PC proliferation induced by HMGB1 in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	37-40
24838617-10	2014	LY294002 effectively reduced phospho-Akt levels and reduced NS/PC proliferation induced by HMGB1 in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	high mobility group box 1	Homo sapiens	91-96
24769160-10	2014	The addition of the PKA inhibitor KT5720, the MAP kinase inhibitor U0126, and the PI3 kinase inhibitor LY294002 abrogated the GPR3-mediated antiapoptotic effect in a potassium-deprivation model of apoptosis, whereas the PKC inhibitor Go6976 did not affect the antiapoptotic function of GPR3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	G-protein coupled receptor 3	Mus musculus	126-130
24769160-10	2014	The addition of the PKA inhibitor KT5720, the MAP kinase inhibitor U0126, and the PI3 kinase inhibitor LY294002 abrogated the GPR3-mediated antiapoptotic effect in a potassium-deprivation model of apoptosis, whereas the PKC inhibitor Go6976 did not affect the antiapoptotic function of GPR3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	G-protein coupled receptor 3	Mus musculus	286-290
24889918-10	2014	Treating CNE2Z cells with LY294002 inhibited p-Akt (Ser473), vimentin and alpha-SMA expression but upregulated E-cadherin expression, leading to significantly attenuated cell invasion and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	47-50
24889918-10	2014	Treating CNE2Z cells with LY294002 inhibited p-Akt (Ser473), vimentin and alpha-SMA expression but upregulated E-cadherin expression, leading to significantly attenuated cell invasion and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	vimentin	Homo sapiens	61-69
24889918-10	2014	Treating CNE2Z cells with LY294002 inhibited p-Akt (Ser473), vimentin and alpha-SMA expression but upregulated E-cadherin expression, leading to significantly attenuated cell invasion and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	actin alpha 2, smooth muscle, aorta	Mus musculus	74-83
24889918-10	2014	Treating CNE2Z cells with LY294002 inhibited p-Akt (Ser473), vimentin and alpha-SMA expression but upregulated E-cadherin expression, leading to significantly attenuated cell invasion and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	cadherin 1	Homo sapiens	111-121
24889918-11	2014	Administration of mice with LY294002 resulted in upregulation of membrane E-cadherin, and downregulation of vimentin and alpha-SMA in CNE2Z xenografts, with reduced pulmonary metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cadherin 1	Mus musculus	74-84
24889918-11	2014	Administration of mice with LY294002 resulted in upregulation of membrane E-cadherin, and downregulation of vimentin and alpha-SMA in CNE2Z xenografts, with reduced pulmonary metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	vimentin	Homo sapiens	108-116
24889918-11	2014	Administration of mice with LY294002 resulted in upregulation of membrane E-cadherin, and downregulation of vimentin and alpha-SMA in CNE2Z xenografts, with reduced pulmonary metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	actin alpha 2, smooth muscle, aorta	Mus musculus	121-130
24889918-12	2014	Our findings suggest that inhibiting the PI3K/Akt pathway using LY294002 attenuated NPC metastasis via induction of EMrT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Homo sapiens	46-49
24613819-7	2014	Furthermore, phosphorylation of TNF-alpha-induced phosphatidyl-inositol 3 kinase (PI3K)/Akt was significantly downregulated in the presence of GA accompanying with the inhibition of NF-kappaB activity, and as presumed, the specific PI3K/Akt inhibitor LY294002 significantly decreased MMP-9 and VEGF expression as well as activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	tumor necrosis factor	Homo sapiens	32-41
24613819-7	2014	Furthermore, phosphorylation of TNF-alpha-induced phosphatidyl-inositol 3 kinase (PI3K)/Akt was significantly downregulated in the presence of GA accompanying with the inhibition of NF-kappaB activity, and as presumed, the specific PI3K/Akt inhibitor LY294002 significantly decreased MMP-9 and VEGF expression as well as activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	AKT serine/threonine kinase 1	Homo sapiens	88-91
25077631-10	2014	Btk, c-Src and PI3K were also involved in MALP-2-induced HO-1 expression, as revealed by specific inhibitors LFM-A13, PP1 and LY294002, or by transfection with siRNA of c-Src.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	Bruton tyrosine kinase	Homo sapiens	0-3
25077631-12	2014	Furthermore, MALP-2 stimulated the translocation of Nrf2 from the cytosol to the nucleus and Nrf2 binding to the ARE site in the HO-1 promoter, which could also be inhibited by pretreatment with a PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
25072152-7	2014	In contrast, the PI3K/Akt inhibitor, LY294002, could partially reverse the neuroprotection of ATX in the early period after SAH by downregulating ATX-induced activation of Akt/Bad and upregulating cleaved caspase-3 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
25072152-7	2014	In contrast, the PI3K/Akt inhibitor, LY294002, could partially reverse the neuroprotection of ATX in the early period after SAH by downregulating ATX-induced activation of Akt/Bad and upregulating cleaved caspase-3 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Rattus norvegicus	172-175
24887581-3	2014	Furthermore, when the Akt signaling pathway was blocked by LY294002, an inhibitor of Phosphatidyl Inositol 3-kinase (PI3K), the protective effects of THSG against STS-induced neurotoxicity were abrogated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
24887581-3	2014	Furthermore, when the Akt signaling pathway was blocked by LY294002, an inhibitor of Phosphatidyl Inositol 3-kinase (PI3K), the protective effects of THSG against STS-induced neurotoxicity were abrogated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	85-115
25058399-10	2014	LY294002, a PI3K inhibitor, inhibited HPV-16 oncoprotein-induced activation of Akt, P70S6K, and P85S6K, expression of HIF-1alpha, VEGF, and IL-8, and in vitro angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-128
25058399-10	2014	LY294002, a PI3K inhibitor, inhibited HPV-16 oncoprotein-induced activation of Akt, P70S6K, and P85S6K, expression of HIF-1alpha, VEGF, and IL-8, and in vitro angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	vascular endothelial growth factor A	Homo sapiens	130-134
25058399-10	2014	LY294002, a PI3K inhibitor, inhibited HPV-16 oncoprotein-induced activation of Akt, P70S6K, and P85S6K, expression of HIF-1alpha, VEGF, and IL-8, and in vitro angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
24946212-6	2014	TGF-beta induced AKT activation in mouse PSCs, while the PI3K/AKT inhibitor (LY294002) and the AKT specific inhibitors (perifosine and MK-2206) largely suppressed TGF-beta-induced collagen II, Sox 9, and aggrecan mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	thymoma viral proto-oncogene 1	Mus musculus	62-65
24946212-6	2014	TGF-beta induced AKT activation in mouse PSCs, while the PI3K/AKT inhibitor (LY294002) and the AKT specific inhibitors (perifosine and MK-2206) largely suppressed TGF-beta-induced collagen II, Sox 9, and aggrecan mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	thymoma viral proto-oncogene 1	Mus musculus	62-65
24944017-5	2014	Exposure to GDF5 not only promoted the phosphorylation of both Smad1/5/8 and Akt in cultured brown pre-adipocytes, but also up-regulated Pgc1a and uncoupling protein-1 expression in a manner sensitive to the PI3K/Akt inhibitor Ly294002 as well as retroviral infection with DN-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	227-235	growth differentiation factor 5	Mus musculus	12-16
24946212-6	2014	TGF-beta induced AKT activation in mouse PSCs, while the PI3K/AKT inhibitor (LY294002) and the AKT specific inhibitors (perifosine and MK-2206) largely suppressed TGF-beta-induced collagen II, Sox 9, and aggrecan mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	transforming growth factor, beta 1	Mus musculus	163-171
24944017-6	2014	GDF5 drastically promoted BMP-responsive luciferase reporter activity in a Ly294002-sensitive fashion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	growth differentiation factor 5	Mus musculus	0-4
24946212-6	2014	TGF-beta induced AKT activation in mouse PSCs, while the PI3K/AKT inhibitor (LY294002) and the AKT specific inhibitors (perifosine and MK-2206) largely suppressed TGF-beta-induced collagen II, Sox 9, and aggrecan mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	SRY (sex determining region Y)-box 9	Mus musculus	193-198
24944017-7	2014	Both Ly294002 and DN-Akt markedly inhibited phosphorylation of Smad5 in the nuclei of brown pre-adipocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	SMAD family member 5	Mus musculus	63-68
24769323-14	2014	Blockade of PI3K activity by LY294002, dramatically abolished its anti-apoptotic effect and lowered Akt phosphorylation level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Rattus norvegicus	100-103
24970817-6	2014	Treatment with LY294002, a PI3K inhibitor, resulted in cell cycle arrest without apoptosis and a concomitant down-regulation of cap-dependent translation by the suppression of the PI3K/AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	185-188
24970817-6	2014	Treatment with LY294002, a PI3K inhibitor, resulted in cell cycle arrest without apoptosis and a concomitant down-regulation of cap-dependent translation by the suppression of the PI3K/AKT/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mechanistic target of rapamycin kinase	Homo sapiens	189-193
24632945-6	2014	This effect was mediated by the NO/PI3K/Akt pathway since it was blocked by the following: (a) the NOS inhibitors L-NAME and 7-Nitroindazole, (b) the IP3K/Akt inhibitors LY294002, wortmannin and the Akt-negative dominant, (c) the NCX1 and NCX3 siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Homo sapiens	40-43
25028796-6	2014	Fucoxanthin treatment increased phosphorylation of Akt (active form), an up-regulator of Nrf2 and exposure to LY294002, a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, suppressed the fucoxanthin-induced activation of Akt, Nrf2, resulting in decreased GCLC and GSS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Homo sapiens	51-54
25028796-6	2014	Fucoxanthin treatment increased phosphorylation of Akt (active form), an up-regulator of Nrf2 and exposure to LY294002, a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, suppressed the fucoxanthin-induced activation of Akt, Nrf2, resulting in decreased GCLC and GSS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	122-147
25028796-6	2014	Fucoxanthin treatment increased phosphorylation of Akt (active form), an up-regulator of Nrf2 and exposure to LY294002, a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, suppressed the fucoxanthin-induced activation of Akt, Nrf2, resulting in decreased GCLC and GSS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Homo sapiens	155-158
25028796-6	2014	Fucoxanthin treatment increased phosphorylation of Akt (active form), an up-regulator of Nrf2 and exposure to LY294002, a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, suppressed the fucoxanthin-induced activation of Akt, Nrf2, resulting in decreased GCLC and GSS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Homo sapiens	155-158
25028796-6	2014	Fucoxanthin treatment increased phosphorylation of Akt (active form), an up-regulator of Nrf2 and exposure to LY294002, a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, suppressed the fucoxanthin-induced activation of Akt, Nrf2, resulting in decreased GCLC and GSS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	NFE2 like bZIP transcription factor 2	Homo sapiens	224-228
25028796-6	2014	Fucoxanthin treatment increased phosphorylation of Akt (active form), an up-regulator of Nrf2 and exposure to LY294002, a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, suppressed the fucoxanthin-induced activation of Akt, Nrf2, resulting in decreased GCLC and GSS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	glutamate-cysteine ligase catalytic subunit	Homo sapiens	253-257
24632945-6	2014	This effect was mediated by the NO/PI3K/Akt pathway since it was blocked by the following: (a) the NOS inhibitors L-NAME and 7-Nitroindazole, (b) the IP3K/Akt inhibitors LY294002, wortmannin and the Akt-negative dominant, (c) the NCX1 and NCX3 siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	inositol-trisphosphate 3-kinase B	Homo sapiens	150-154
24632945-6	2014	This effect was mediated by the NO/PI3K/Akt pathway since it was blocked by the following: (a) the NOS inhibitors L-NAME and 7-Nitroindazole, (b) the IP3K/Akt inhibitors LY294002, wortmannin and the Akt-negative dominant, (c) the NCX1 and NCX3 siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Homo sapiens	155-158
24632945-6	2014	This effect was mediated by the NO/PI3K/Akt pathway since it was blocked by the following: (a) the NOS inhibitors L-NAME and 7-Nitroindazole, (b) the IP3K/Akt inhibitors LY294002, wortmannin and the Akt-negative dominant, (c) the NCX1 and NCX3 siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Homo sapiens	155-158
24632945-6	2014	This effect was mediated by the NO/PI3K/Akt pathway since it was blocked by the following: (a) the NOS inhibitors L-NAME and 7-Nitroindazole, (b) the IP3K/Akt inhibitors LY294002, wortmannin and the Akt-negative dominant, (c) the NCX1 and NCX3 siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	solute carrier family 8 member A1	Homo sapiens	230-234
24632945-6	2014	This effect was mediated by the NO/PI3K/Akt pathway since it was blocked by the following: (a) the NOS inhibitors L-NAME and 7-Nitroindazole, (b) the IP3K/Akt inhibitors LY294002, wortmannin and the Akt-negative dominant, (c) the NCX1 and NCX3 siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	solute carrier family 8 member A3	Homo sapiens	239-243
24720662-12	2014	Pretreatment with ICI-182780, LY294002, or Snpp abolished NGR1-mediated neuroprotection against oxidative stress and apoptosis in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	reticulon 4 receptor	Rattus norvegicus	58-62
24452839-12	2014	The PI3K inhibitor LY294002 suppressed the positive effect of IL-11 on cell growth, and antagonized the protective effect of IL-11 against cell death after neutron IR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	interleukin 11	Mus musculus	62-67
24452839-12	2014	The PI3K inhibitor LY294002 suppressed the positive effect of IL-11 on cell growth, and antagonized the protective effect of IL-11 against cell death after neutron IR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	interleukin 11	Mus musculus	125-130
24795232-7	2014	The induction of HO-1 by R-scy was inhibited by pretreatment with an antioxidant, N-acetyl-cysteine (NAC), as well as SB203580 and LY294002, inhibitors for p38 MAPK and PI3K/Akt, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	heme oxygenase 1	Mus musculus	17-21
24804928-4	2014	Stem cell factor (SCF) induced CSC migration in a concentration-dependent manner, which could be blocked with an SCF antibody as well as a PI3K/AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	AKT serine/threonine kinase 1	Rattus norvegicus	144-147
24758182-9	2014	RESULTS: Unlike AS-605240, both LY294002 (10 muM) and PI-103 (5 muM) significantly decreased HAS2 transcripts/HA accumulation and adipogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	hyaluronan synthase 2	Homo sapiens	93-97
24804928-4	2014	Stem cell factor (SCF) induced CSC migration in a concentration-dependent manner, which could be blocked with an SCF antibody as well as a PI3K/AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	KIT ligand	Rattus norvegicus	0-16
24804928-4	2014	Stem cell factor (SCF) induced CSC migration in a concentration-dependent manner, which could be blocked with an SCF antibody as well as a PI3K/AKT inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	KIT ligand	Rattus norvegicus	18-21
24792734-9	2014	Moreover, we found that LY294002, an antagonist for phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway, abolished the inhibitory effect of Rd on GSK-3beta activity and tau phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	52-81
23475563-7	2014	The PI3K inhibitor LY294002 suppressed Akt activation similar to AMR-Me and potentiated AMR-Me induced apoptosis in MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	39-42
24952510-6	2014	While LY294002 reduced the protein level of pAKT, the over-expression of miR-29c can further decrease its level in T24 cells pretreated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	microRNA 29c	Homo sapiens	73-80
24792734-9	2014	Moreover, we found that LY294002, an antagonist for phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway, abolished the inhibitory effect of Rd on GSK-3beta activity and tau phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Rattus norvegicus	89-92
24792734-9	2014	Moreover, we found that LY294002, an antagonist for phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway, abolished the inhibitory effect of Rd on GSK-3beta activity and tau phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	glycogen synthase kinase 3 beta	Rattus norvegicus	153-162
24819473-6	2014	Using PD98059 and LY294002, specific inhibitors of MEK and PI-3K, respectively, we were able to identify the signal transduction pathways involved in peptide-induced STAT3 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	signal transducer and activator of transcription 3	Mus musculus	166-171
24959678-7	2014	LY294002 (a PI3K inhibitor) could reverse this effect, which suggested the endothelial PI3K/Akt pathway involved in the mechanism underlying DA-induced relaxation of pulmonary artery.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	92-95
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	RELA proto-oncogene, NF-kB subunit	Homo sapiens	30-33
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	MIR7-3 host gene	Homo sapiens	66-71
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	AKT serine/threonine kinase 1	Homo sapiens	113-116
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	nuclear factor kappa B subunit 1	Homo sapiens	192-201
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	prostaglandin E receptor 4	Homo sapiens	274-278
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	snail family transcriptional repressor 1	Homo sapiens	295-300
24760275-17	2014	The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	MIR7-3 host gene	Homo sapiens	317-322
24949720-3	2014	Based on the previous finding that PI3K inhibitor LY294002 abolishes H2S-induced Akt phosphorylation and cardioprotection, it is accepted that PI3K is the mediator of H2S-induced Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Rattus norvegicus	81-84
24949720-3	2014	Based on the previous finding that PI3K inhibitor LY294002 abolishes H2S-induced Akt phosphorylation and cardioprotection, it is accepted that PI3K is the mediator of H2S-induced Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
24949720-4	2014	However, LY294002 inhibits both PI3K and mTOR, and PI3K only recruits Akt to the membrane where Akt is phosphorylated by Akt kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	mechanistic target of rapamycin kinase	Rattus norvegicus	41-45
24941119-8	2014	The PI3K inhibitor LY294002 reverses the AEG-1 dependent effects on Akt phosphorylation, Bcl-2 expression and anoikis resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	metadherin	Homo sapiens	41-46
24967183-10	2014	In the presence of the LY294002, the potent PI3K inhibitor, the p-Akt was significantly attenuated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	66-69
25003810-7	2014	Our data demonstrate that LY294002, SB431542, LDN193189, and Noggin pretreatment inhibit Snail-induced Nanog expression during EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	snail family transcriptional repressor 1	Homo sapiens	89-94
24955034-6	2014	The induction of lamellipodia was demonstrated to occur via the Akt pathway because the addition of the Akt inhibitor LY294002 inhibited lamellipodia in both Cav-1-overexpressing and H23 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	AKT serine/threonine kinase 1	Homo sapiens	64-67
24955034-6	2014	The induction of lamellipodia was demonstrated to occur via the Akt pathway because the addition of the Akt inhibitor LY294002 inhibited lamellipodia in both Cav-1-overexpressing and H23 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	AKT serine/threonine kinase 1	Homo sapiens	104-107
24955034-6	2014	The induction of lamellipodia was demonstrated to occur via the Akt pathway because the addition of the Akt inhibitor LY294002 inhibited lamellipodia in both Cav-1-overexpressing and H23 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	caveolin 1	Homo sapiens	158-163
24690261-10	2014	The PI3K inhibitors (wortmannin and LY294002) decreased the EAAT3 response, although there were no differences among the groups comprising ondansetron, PI3K inhibitors, and PI3K inhibitors plus ondansetron.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	solute carrier family 1 member 1	Rattus norvegicus	60-65
25003810-7	2014	Our data demonstrate that LY294002, SB431542, LDN193189, and Noggin pretreatment inhibit Snail-induced Nanog expression during EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	Nanog homeobox	Homo sapiens	103-108
25003810-10	2014	Moreover, LY294002 pretreatment prevented Akt hyperactivation and reactivated GSK3beta without altering Smad1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	42-45
25003810-10	2014	Moreover, LY294002 pretreatment prevented Akt hyperactivation and reactivated GSK3beta without altering Smad1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	glycogen synthase kinase 3 beta	Homo sapiens	78-86
24941119-8	2014	The PI3K inhibitor LY294002 reverses the AEG-1 dependent effects on Akt phosphorylation, Bcl-2 expression and anoikis resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	68-71
24941119-8	2014	The PI3K inhibitor LY294002 reverses the AEG-1 dependent effects on Akt phosphorylation, Bcl-2 expression and anoikis resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	BCL2 apoptosis regulator	Homo sapiens	89-94
24563318-7	2014	TGF-beta1-induced alpha-SMA expression was significantly decreased by LY294002 and Akt siRNA indicating that these changes are mediated by the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	transforming growth factor beta 1	Homo sapiens	0-9
24841907-4	2014	In addition, the PI3K/Akt inhibitor LY294002 enhanced Beclin-1, LC3-II, and poly(ADP-ribose) polymerase (PARP) cleavage levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	22-25
24841907-4	2014	In addition, the PI3K/Akt inhibitor LY294002 enhanced Beclin-1, LC3-II, and poly(ADP-ribose) polymerase (PARP) cleavage levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	beclin 1	Homo sapiens	54-62
24841907-4	2014	In addition, the PI3K/Akt inhibitor LY294002 enhanced Beclin-1, LC3-II, and poly(ADP-ribose) polymerase (PARP) cleavage levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	poly(ADP-ribose) polymerase 1	Homo sapiens	76-103
24841907-4	2014	In addition, the PI3K/Akt inhibitor LY294002 enhanced Beclin-1, LC3-II, and poly(ADP-ribose) polymerase (PARP) cleavage levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	poly(ADP-ribose) polymerase 1	Homo sapiens	105-109
24936148-7	2014	These effects of S100A4 were abolished by treatment with either the specific PI3K/Akt inhibitor LY294002, or the specific mTOR/p70S6K inhibitor rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	AKT serine/threonine kinase 1	Homo sapiens	82-85
24936148-8	2014	Furthermore, overexpression of S100A4 resulted in upregulation of VEGF and downregulation of E-cadherin, which were strongly reversed by either LY294002 or rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	vascular endothelial growth factor A	Homo sapiens	66-70
24936148-8	2014	Furthermore, overexpression of S100A4 resulted in upregulation of VEGF and downregulation of E-cadherin, which were strongly reversed by either LY294002 or rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	cadherin 1	Homo sapiens	93-103
24892425-10	2014	Investigation into the mechanism of Tie2 receptor upregulation on CD14+ monocytes by CSF1 revealed a synergistic contribution from the PI3 kinase and HIF pathways as the PI3 kinase inhibitor LY294002, as well as HIF-1alpha-deficient macrophages differentiated from the bone marrow of HIF-1alphafl/fl/LysMcre mice, diminished CSF1-stimulated Tie2 receptor expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	191-199	TEK receptor tyrosine kinase	Mus musculus	36-40
24563318-7	2014	TGF-beta1-induced alpha-SMA expression was significantly decreased by LY294002 and Akt siRNA indicating that these changes are mediated by the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Homo sapiens	148-151
24896346-6	2014	Administration of VEGF neutralizing antibody or PI3K/Akt pharmacological inhibitor LY294002 blocked the vasculogenesis in CREG over-expressing EB, while supplement of VEGF rescued vasculogenesis deficiency in CREG knocked down EB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	thymoma viral proto-oncogene 1	Mus musculus	53-56
22859221-9	2014	Inhibition of PI3K/Akt which negatively regulates GSK3 activity by LY294002 resulted in a decrease in arsenite-mediated beta-catenin nuclear accumulation, and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Homo sapiens	19-22
22859221-9	2014	Inhibition of PI3K/Akt which negatively regulates GSK3 activity by LY294002 resulted in a decrease in arsenite-mediated beta-catenin nuclear accumulation, and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	catenin beta 1	Homo sapiens	120-132
22859221-9	2014	Inhibition of PI3K/Akt which negatively regulates GSK3 activity by LY294002 resulted in a decrease in arsenite-mediated beta-catenin nuclear accumulation, and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	vascular endothelial growth factor A	Homo sapiens	159-163
24632067-5	2014	Role of MEK/ERK and PI3K/Akt signaling pathway in the melanogenesis was confirmed by using specific inhibitors, PD98059 (for MEK/ERK) and LY294002 (for PI3K/Akt), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	midkine	Mus musculus	8-11
24632067-5	2014	Role of MEK/ERK and PI3K/Akt signaling pathway in the melanogenesis was confirmed by using specific inhibitors, PD98059 (for MEK/ERK) and LY294002 (for PI3K/Akt), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	thymoma viral proto-oncogene 1	Mus musculus	25-28
24896346-6	2014	Administration of VEGF neutralizing antibody or PI3K/Akt pharmacological inhibitor LY294002 blocked the vasculogenesis in CREG over-expressing EB, while supplement of VEGF rescued vasculogenesis deficiency in CREG knocked down EB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	cellular repressor of E1A-stimulated genes 1	Mus musculus	122-126
24446161-5	2014	Pretreatments with LY294002, wortmannin, and staurosporine completely blocked the induction effect, suggesting the involvement of both phosphoinositide 3-kinase (PI 3-K) and protein kinase C (PKC) pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	135-160
23280703-5	2014	Knockdown of TWIST in MG-63 cells significantly increased the soluble beta-catenin level, phosphorylation of GSK-3beta at serine 9, the mRNA level of beta-catenin signaling target genes, and cell survival against cisplatin, which was reversed by knocking down beta-catenin or phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	323-331	twist family bHLH transcription factor 1	Homo sapiens	13-18
24442713-5	2014	In addition, PD98059 and LY294002 pretreatment attenuated Ang II-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	angiotensinogen	Homo sapiens	58-64
24442713-5	2014	In addition, PD98059 and LY294002 pretreatment attenuated Ang II-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	heme oxygenase 1	Homo sapiens	73-77
24602480-9	2014	The antiapoptotic effect of resveratrol in SAH rats could be partially abrogated by the PI3K/Akt signaling inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
24356998-7	2014	In A549 cells, stable knockdown of HtrA1 expression promoted cancer stem cell-like properties and CDDP insensitivity, however, these effects were blocked by inhibition of PI3K/Akt pathway using LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	HtrA serine peptidase 1	Homo sapiens	35-40
24356998-7	2014	In A549 cells, stable knockdown of HtrA1 expression promoted cancer stem cell-like properties and CDDP insensitivity, however, these effects were blocked by inhibition of PI3K/Akt pathway using LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	AKT serine/threonine kinase 1	Homo sapiens	176-179
24356998-9	2014	In vivo studies, HtrA1 knockdown promoted tumorigenesis and conferred CDDP resistance in xenograft A549 tumors, which were reversed by intraperitoneal injection of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	HtrA serine peptidase 1	Homo sapiens	17-22
23604952-6	2014	PRPr led to the phosphorylation of Erk1/2 and Akt in HUVECs, and the induction of proliferation and migration by PRPr was suppressed by PRPr inhibitors PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	mitogen-activated protein kinase 3	Homo sapiens	35-41
23604952-6	2014	PRPr led to the phosphorylation of Erk1/2 and Akt in HUVECs, and the induction of proliferation and migration by PRPr was suppressed by PRPr inhibitors PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	AKT serine/threonine kinase 1	Homo sapiens	46-49
24691522-6	2014	Inhibition of the PI3K/Akt pathway by LY294002 partly eliminates the protective effects of Sevo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
24598112-8	2014	The IGF-I dose dependently increased the HIF-2alpha expression levels in AP(+)GSCs; and, the inhibition of IGF-IR by RNA interference (shIGF-IR) or LY294002 (PI3K inhibitor)/Rapamycin (mTOR inhibitor) effectively suppressed the IGF-I- and/or hypoxia-induced HIF-2alpha and Oct-4 expression, suggesting that the IGF-IR and its downstream Akt/mTOR signaling are involved in the IGF-I/hypoxia effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	insulin-like growth factor 1	Mus musculus	4-9
24336673-5	2014	Progesterone induces secretin expression in ovariectomized mice and cultured stromal cells, which is abrogated by specific LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	secretin	Mus musculus	21-29
24700142-7	2014	Finally, LY294002, an inhibitor of PI3K, also markedly abolished SOX2-induced activation of the Akt/mTOR pathway and increased cell invasion and MMP-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	SRY-box transcription factor 2	Homo sapiens	65-69
24700142-7	2014	Finally, LY294002, an inhibitor of PI3K, also markedly abolished SOX2-induced activation of the Akt/mTOR pathway and increased cell invasion and MMP-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	96-99
24700142-7	2014	Finally, LY294002, an inhibitor of PI3K, also markedly abolished SOX2-induced activation of the Akt/mTOR pathway and increased cell invasion and MMP-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	mechanistic target of rapamycin kinase	Homo sapiens	100-104
24700142-7	2014	Finally, LY294002, an inhibitor of PI3K, also markedly abolished SOX2-induced activation of the Akt/mTOR pathway and increased cell invasion and MMP-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	matrix metallopeptidase 2	Homo sapiens	145-150
24851866-7	2014	Application of either LY294002 or wortmannin inhibited the activation of both S6K1 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	ribosomal protein S6 kinase B1	Homo sapiens	78-90
24909280-1	2014	OBJECTIVE: To investigate the effect of phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002 combined with mitogen activated protein kinase kinase (MEK) inhibitor AZD6244 on the proliferation of cisplatin-resistant SKOV3/DDP ovarian cancer cell line.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	40-69
24878845-11	2014	In addition, LY294002 blocked AKT and STAT phosphorylation, and also up-regulated expression levels of type I and type III collagen (Col 1 and Col 3) and alpha-smooth muscle actin (alpha-SMA) in IL-10-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	30-33
24878845-11	2014	In addition, LY294002 blocked AKT and STAT phosphorylation, and also up-regulated expression levels of type I and type III collagen (Col 1 and Col 3) and alpha-smooth muscle actin (alpha-SMA) in IL-10-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	interleukin 10	Homo sapiens	195-200
24805814-6	2014	When the phosphorylation of ERK1/2 and PI3K/AKT was inhibited by PD98059 and LY294002, respectively, the decreased proliferation and invasion induced by BMP9 knock down were eliminated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	mitogen-activated protein kinase 3	Homo sapiens	28-34
24708926-8	2014	Either Janus kinase 2 (JAK2) inhibitor AG490 or phosphatidyl inositol-3"-phosphate-kinase (PI3K) inhibitor LY294002 blocked the effects of CNTF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	48-89
24708926-8	2014	Either Janus kinase 2 (JAK2) inhibitor AG490 or phosphatidyl inositol-3"-phosphate-kinase (PI3K) inhibitor LY294002 blocked the effects of CNTF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	ciliary neurotrophic factor	Homo sapiens	139-143
24686182-10	2014	While, the effect of Apelin-13 on Bax, Bcl-2, caspase-3 and cleaved caspase-3 was attenuated by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	BCL2-associated X protein	Mus musculus	34-37
24686182-10	2014	While, the effect of Apelin-13 on Bax, Bcl-2, caspase-3 and cleaved caspase-3 was attenuated by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	caspase 3	Mus musculus	46-55
24686182-10	2014	While, the effect of Apelin-13 on Bax, Bcl-2, caspase-3 and cleaved caspase-3 was attenuated by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	caspase 3	Mus musculus	68-77
24634221-5	2014	LY294002, an inhibitor of PI3k, abolished HGF-induced PI3k (Tyr-458), and Akt (Thr-308 and Ser-473) phosphorylation and suppressed lamellipodia formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hepatocyte growth factor	Homo sapiens	42-45
24634221-5	2014	LY294002, an inhibitor of PI3k, abolished HGF-induced PI3k (Tyr-458), and Akt (Thr-308 and Ser-473) phosphorylation and suppressed lamellipodia formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	74-77
24805814-6	2014	When the phosphorylation of ERK1/2 and PI3K/AKT was inhibited by PD98059 and LY294002, respectively, the decreased proliferation and invasion induced by BMP9 knock down were eliminated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	44-47
24805814-6	2014	When the phosphorylation of ERK1/2 and PI3K/AKT was inhibited by PD98059 and LY294002, respectively, the decreased proliferation and invasion induced by BMP9 knock down were eliminated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	growth differentiation factor 2	Homo sapiens	153-157
24303786-5	2014	Nuclear translocation of Nrf2 in macrophages was inhibited by the phosphatidylinositol 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	nuclear factor, erythroid derived 2, like 2	Mus musculus	25-29
24667703-9	2014	The MSC-CM-mediated induction of beta cell proliferation was completely blocked by the PI3K/Akt inhibitor LY294002 but not by the MEK/Erk inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	thymoma viral proto-oncogene 1	Mus musculus	92-95
24412919-10	2014	Conversely, LY294002, a highly selective inhibitor of PI3K, could block phosphorylation of Akt and effect of miR-200b.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Homo sapiens	91-94
24375569-5	2014	Inhibition of PI3K/Akt with LY294002 or ERK1/2 with PD98059 significantly attenuated IL-6 upregulation, and IL-6 expression was abolished by inhibiting both pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	thymoma viral proto-oncogene 1	Mus musculus	19-22
24375611-7	2014	Western blot assay showed that, after treatment with simvastatin, the phosphorylation of Akt/mTOR/p70 S6K and FoxO3a were up-regulated in rapamycin-induced CMECs, which was significantly reversed by pretreatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	AKT serine/threonine kinase 1	Rattus norvegicus	89-92
24375611-7	2014	Western blot assay showed that, after treatment with simvastatin, the phosphorylation of Akt/mTOR/p70 S6K and FoxO3a were up-regulated in rapamycin-induced CMECs, which was significantly reversed by pretreatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	mechanistic target of rapamycin kinase	Rattus norvegicus	93-97
24375611-7	2014	Western blot assay showed that, after treatment with simvastatin, the phosphorylation of Akt/mTOR/p70 S6K and FoxO3a were up-regulated in rapamycin-induced CMECs, which was significantly reversed by pretreatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	ribosomal protein S6 kinase B1	Rattus norvegicus	98-105
24375611-7	2014	Western blot assay showed that, after treatment with simvastatin, the phosphorylation of Akt/mTOR/p70 S6K and FoxO3a were up-regulated in rapamycin-induced CMECs, which was significantly reversed by pretreatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	forkhead box O3	Rattus norvegicus	110-116
24458982-9	2014	VEGF-induced EphA2 expression was suppressed in the brain endothelium following treatments with the PI3K inhibitor LY294002, Akt inhibitor or transfection with the dominant-negative PI3K mutants (Deltap110).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	vascular endothelial growth factor A	Homo sapiens	0-4
24458982-9	2014	VEGF-induced EphA2 expression was suppressed in the brain endothelium following treatments with the PI3K inhibitor LY294002, Akt inhibitor or transfection with the dominant-negative PI3K mutants (Deltap110).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	EPH receptor A2	Homo sapiens	13-18
24412919-10	2014	Conversely, LY294002, a highly selective inhibitor of PI3K, could block phosphorylation of Akt and effect of miR-200b.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	microRNA 200b	Homo sapiens	109-117
24599886-7	2014	We then showed that the DAF gene expression was up-regulated and the Dr(+) E. coli adhesion increased after the suppression of PI3K/Akt pathway in Ishikawa cells using inhibitor LY294002, and a plasmid which allowed the expression of PI3K/Akt regulatory protein PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	CD55 molecule (Cromer blood group)	Homo sapiens	24-27
24528157-8	2014	Intercepting Akt signaling by specific inhibitor LY294002 blocked the protective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	13-16
24631288-7	2014	However, inhibition of AKT by siRNA or LY294002 treatment decreased p-beta-catenin and survivin levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	catenin beta 1	Homo sapiens	70-82
24940423-7	2014	Intratracheal administration of LY294002 and Akt inhibitor IV to the asthmatic mice was capable of reducing airway inflammation, downregulating the expression of alpha-SMA, type I collagen and fibronectin-1 and increasing the expression of E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	actin alpha 2, smooth muscle, aorta	Mus musculus	162-171
24940423-7	2014	Intratracheal administration of LY294002 and Akt inhibitor IV to the asthmatic mice was capable of reducing airway inflammation, downregulating the expression of alpha-SMA, type I collagen and fibronectin-1 and increasing the expression of E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	cadherin 1	Mus musculus	240-250
24594219-6	2014	Pre-treatment with PI3K inhibitors, wortmannin or LY294002 prevented the activation of Akt brought on by plantar incision in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	thymoma viral proto-oncogene 1	Mus musculus	87-90
24599886-7	2014	We then showed that the DAF gene expression was up-regulated and the Dr(+) E. coli adhesion increased after the suppression of PI3K/Akt pathway in Ishikawa cells using inhibitor LY294002, and a plasmid which allowed the expression of PI3K/Akt regulatory protein PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	AKT serine/threonine kinase 1	Homo sapiens	132-135
24390959-9	2014	Meanwhile, the EPO-dependent neuroprotection was notably reversed by pretreatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	erythropoietin	Homo sapiens	15-18
24122208-11	2014	In addition, the PI3K/Akt signaling pathway was activated in iMSCs(Fn14) which allowed higher Akt phosphorylation (p-Akt) levels and SMA levels, whereas, it was attenuated by LY294002 (PI3K/Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	AKT serine/threonine kinase 1	Homo sapiens	22-25
24122208-11	2014	In addition, the PI3K/Akt signaling pathway was activated in iMSCs(Fn14) which allowed higher Akt phosphorylation (p-Akt) levels and SMA levels, whereas, it was attenuated by LY294002 (PI3K/Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	TNF receptor superfamily member 12A	Homo sapiens	67-71
24638941-5	2014	The expression levels of the above genes in the pseudopregnant group and in the group injected with the PI3K/Akt inhibitor, LY294002, were markedly lower than those in the pregnant group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	thymoma viral proto-oncogene 1	Mus musculus	109-112
24390959-9	2014	Meanwhile, the EPO-dependent neuroprotection was notably reversed by pretreatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	121-150
24573187-5	2014	The treatment with the AMPK (compound C) and protein kinase Akt/protein kinase B (Akt; LY294002) inhibitor significantly suppressed the apelin-13-induced AMPK, Akt and eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	60-63
24573187-5	2014	The treatment with the AMPK (compound C) and protein kinase Akt/protein kinase B (Akt; LY294002) inhibitor significantly suppressed the apelin-13-induced AMPK, Akt and eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	protein tyrosine kinase 2 beta	Homo sapiens	64-80
24573187-5	2014	The treatment with the AMPK (compound C) and protein kinase Akt/protein kinase B (Akt; LY294002) inhibitor significantly suppressed the apelin-13-induced AMPK, Akt and eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	82-85
24573187-5	2014	The treatment with the AMPK (compound C) and protein kinase Akt/protein kinase B (Akt; LY294002) inhibitor significantly suppressed the apelin-13-induced AMPK, Akt and eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	apelin	Homo sapiens	136-142
24573187-5	2014	The treatment with the AMPK (compound C) and protein kinase Akt/protein kinase B (Akt; LY294002) inhibitor significantly suppressed the apelin-13-induced AMPK, Akt and eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	154-158
24573187-5	2014	The treatment with the AMPK (compound C) and protein kinase Akt/protein kinase B (Akt; LY294002) inhibitor significantly suppressed the apelin-13-induced AMPK, Akt and eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	82-85
24685819-8	2014	The sustained hypoxic contraction was associated with altered phosphorylation of MLC and Akt, which was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	modulator of VRAC current 1	Homo sapiens	81-84
24765145-4	2014	The human SGC-7901 GC cells under hypoxic conditions were pretreated with the PI3K inhibitor, LY294002 (40 muM), and paclitaxel (0.1 muM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	latexin	Homo sapiens	107-110
24425104-9	2014	After intervention by use of AFP monoclonal antibodies or LY294002 inhibitor, the PIK and Akt protein expression in HepG2 cell was significantly decreased (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Homo sapiens	90-93
24685819-8	2014	The sustained hypoxic contraction was associated with altered phosphorylation of MLC and Akt, which was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	89-92
24685819-9	2014	The sustained hypoxic contraction was also accompanied with increased phosphorylation of MYPT1, which was inhibited by LY294002 and Y27632.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	89-94
25030585-7	2014	The expression of mTOR and Beclin1 mRNA and protein was significantly different among the five groups: the (Saquinavair+DDP) group of, Saquinavair group, LY294002 group, DDP group and control group (P &lt; 0.001) .	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	mechanistic target of rapamycin kinase	Homo sapiens	18-22
24854554-6	2014	Exogenous Tbeta10 can promote the expression of VEGF-C mRNA and protein in lung cancer cell lines A549 and LK2 (P&lt;0.05), and this effect can be inhibited by use AKT inhibitor LY294002 (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	vascular endothelial growth factor C	Homo sapiens	48-54
24854554-6	2014	Exogenous Tbeta10 can promote the expression of VEGF-C mRNA and protein in lung cancer cell lines A549 and LK2 (P&lt;0.05), and this effect can be inhibited by use AKT inhibitor LY294002 (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	AKT serine/threonine kinase 1	Homo sapiens	164-167
24632336-8	2014	The expression of phosphorylated Akt (p-Akt) and the number of mature oligodendrocytes were also markedly increased by catalpol treatment, and these effects were reversed by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
24632336-8	2014	The expression of phosphorylated Akt (p-Akt) and the number of mature oligodendrocytes were also markedly increased by catalpol treatment, and these effects were reversed by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	AKT serine/threonine kinase 1	Rattus norvegicus	40-43
24632018-12	2014	The treatment of LY294002, an Akt inhibitor, significantly inhibited the volatile oil-mediated ARE transcriptional activity, as well as the cell protective effect of NRR oil.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	AKT serine/threonine kinase 1	Rattus norvegicus	30-33
24941851-7	2014	Results The proliferation of HMCs induced by high insulin could be significantly lowered, and the protein expression of IRS-1 and PI-3K could be down-regulated in the JTYSR group and the LY294002 group (P &lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	molybdenum cofactor sulfurase	Homo sapiens	29-33
24941851-7	2014	Results The proliferation of HMCs induced by high insulin could be significantly lowered, and the protein expression of IRS-1 and PI-3K could be down-regulated in the JTYSR group and the LY294002 group (P &lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	insulin receptor substrate 1	Homo sapiens	120-125
24941851-8	2014	Compared with the LY294002 group, the protein expression of IRS-1 and PI-3K could be slightly down-regulated in the JTYSR group (P &lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	insulin receptor substrate 1	Homo sapiens	60-65
24613761-14	2014	The 3-min OGD-induced neuroprotection was inhibited by LY294002, an Akt activation inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	68-71
24582967-7	2014	Akt inhibition by LY294002 abrogated the preventive effect of rTM on FK506-induced Akt inactivation and the suppressive effect of rTM on FK506-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	0-3
24582967-7	2014	Akt inhibition by LY294002 abrogated the preventive effect of rTM on FK506-induced Akt inactivation and the suppressive effect of rTM on FK506-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	83-86
24646745-8	2014	However, the RvD1 receptor (formyl-peptide receptor type 2 [FPR2], also called ALX [the lipoxin A4 receptor]) inhibitor (BOC-2), cAMP inhibitor (Rp-cAMP), and PI3K inhibitor (LY294002) not only blocked RvD1"s effects on the expression of ENaC alpha in vitro, but also inhibited the AFC in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	formyl peptide receptor 2	Rattus norvegicus	60-64
23604117-10	2014	LY294002, a specific inhibitor of phosphatidylinositol-3-kinase (PI3K), significantly impaired the ability of Nef to promote vIL-6-induced tumorigenesis in an allograft model of nude mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	TNFAIP3 interacting protein 1	Mus musculus	110-113
23604117-10	2014	LY294002, a specific inhibitor of phosphatidylinositol-3-kinase (PI3K), significantly impaired the ability of Nef to promote vIL-6-induced tumorigenesis in an allograft model of nude mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	K2	Human gammaherpesvirus 8	125-130
24569994-7	2014	Moreover, treatment of fibroblasts over-expressing tTG with PP2, or with inhibitors that inactivate components of the PI3-kinase pathway, including PI3-kinase (LY294002) and mTORC1 (rapamycin), ablated the tTG-promoted survival of the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	transglutaminase 2	Homo sapiens	51-54
24582811-11	2014	Specific inhibition of ERK1/2 by U0126 or PI3K by LY294002 reduced the IGF1-induced differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	mitogen-activated protein kinase 3	Mus musculus	23-29
24582811-11	2014	Specific inhibition of ERK1/2 by U0126 or PI3K by LY294002 reduced the IGF1-induced differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	insulin-like growth factor 1	Mus musculus	71-75
24774073-4	2014	beta-Hydroxy-beta-methylbutyrate up-regulated phosphorylation of Akt and mTOR, and these effects were completely abolished in the presence of PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	AKT serine/threonine kinase 1	Homo sapiens	65-68
24296153-8	2014	Specific inhibitors of calcium/calmodulin kinase II (CaMKII), KN-93, protein kinase A (PKA), H-89, or phosphatidylinositol 3-kinase (PI3K), LY294002, significantly decreased the effects of antidepressant drugs on dendritic outgrowth, whereas this effect was observed only with tianeptine for the PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	102-131
24535016-0	2014	PI3K inhibitor LY294002 inhibits activation of the Akt/mTOR pathway induced by an oncolytic adenovirus expressing TRAIL and sensitizes multiple myeloma cells to the oncolytic virus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	51-54
24535016-0	2014	PI3K inhibitor LY294002 inhibits activation of the Akt/mTOR pathway induced by an oncolytic adenovirus expressing TRAIL and sensitizes multiple myeloma cells to the oncolytic virus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mechanistic target of rapamycin kinase	Homo sapiens	55-59
24535016-0	2014	PI3K inhibitor LY294002 inhibits activation of the Akt/mTOR pathway induced by an oncolytic adenovirus expressing TRAIL and sensitizes multiple myeloma cells to the oncolytic virus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	TNF superfamily member 10	Homo sapiens	114-119
24535016-9	2014	Combination of ZD55-TRAIL with the PI3K inhibitor LY294002 in RPMI-8226 cells inhibited the virus-mediated activation of mTOR and AKT, thus, promoting cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	mechanistic target of rapamycin kinase	Homo sapiens	121-125
24535016-9	2014	Combination of ZD55-TRAIL with the PI3K inhibitor LY294002 in RPMI-8226 cells inhibited the virus-mediated activation of mTOR and AKT, thus, promoting cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	130-133
24407176-7	2014	The INSM1-enhanced AKT phosphorylation can be inhibited by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	INSM transcriptional repressor 1	Rattus norvegicus	4-9
24407176-7	2014	The INSM1-enhanced AKT phosphorylation can be inhibited by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
24503054-9	2014	The pro-endocrine effect of T3 in the pancreatic explants and in the acinar cell line, was abrogated by the Akt inhibitor Ly294002 indicating the involvement of Akt signaling in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Homo sapiens	108-111
24503054-9	2014	The pro-endocrine effect of T3 in the pancreatic explants and in the acinar cell line, was abrogated by the Akt inhibitor Ly294002 indicating the involvement of Akt signaling in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Homo sapiens	161-164
24580070-5	2014	PI3 inhibitors LY294002 and Wortmannin abolished the effect of IGF-1 on FoxO3a phosphorylation indicating that FoxO3a phosphorylation is mediated by PI3/Akt-1 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	0-3
24580070-5	2014	PI3 inhibitors LY294002 and Wortmannin abolished the effect of IGF-1 on FoxO3a phosphorylation indicating that FoxO3a phosphorylation is mediated by PI3/Akt-1 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	insulin-like growth factor 1	Mus musculus	63-68
24580070-5	2014	PI3 inhibitors LY294002 and Wortmannin abolished the effect of IGF-1 on FoxO3a phosphorylation indicating that FoxO3a phosphorylation is mediated by PI3/Akt-1 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	forkhead box O3	Mus musculus	72-78
24580070-5	2014	PI3 inhibitors LY294002 and Wortmannin abolished the effect of IGF-1 on FoxO3a phosphorylation indicating that FoxO3a phosphorylation is mediated by PI3/Akt-1 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	forkhead box O3	Mus musculus	111-117
24580070-5	2014	PI3 inhibitors LY294002 and Wortmannin abolished the effect of IGF-1 on FoxO3a phosphorylation indicating that FoxO3a phosphorylation is mediated by PI3/Akt-1 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	149-152
24580070-5	2014	PI3 inhibitors LY294002 and Wortmannin abolished the effect of IGF-1 on FoxO3a phosphorylation indicating that FoxO3a phosphorylation is mediated by PI3/Akt-1 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	thymoma viral proto-oncogene 1	Mus musculus	153-158
24530412-9	2014	It is noteworthy that a tyrosine kinase receptor inhibitor, K252a, an MEK-ERK inhibitor (U0126), and a PI3Kinase-Akt inhibitor (LY294002) remarkably attenuated TrkB, ERK, and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	AKT serine/threonine kinase 1	Homo sapiens	113-116
24530412-9	2014	It is noteworthy that a tyrosine kinase receptor inhibitor, K252a, an MEK-ERK inhibitor (U0126), and a PI3Kinase-Akt inhibitor (LY294002) remarkably attenuated TrkB, ERK, and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	neurotrophic receptor tyrosine kinase 2	Homo sapiens	160-164
24530412-9	2014	It is noteworthy that a tyrosine kinase receptor inhibitor, K252a, an MEK-ERK inhibitor (U0126), and a PI3Kinase-Akt inhibitor (LY294002) remarkably attenuated TrkB, ERK, and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	EPH receptor B2	Homo sapiens	166-169
24530412-9	2014	It is noteworthy that a tyrosine kinase receptor inhibitor, K252a, an MEK-ERK inhibitor (U0126), and a PI3Kinase-Akt inhibitor (LY294002) remarkably attenuated TrkB, ERK, and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	AKT serine/threonine kinase 1	Homo sapiens	175-178
24530412-9	2014	It is noteworthy that a tyrosine kinase receptor inhibitor, K252a, an MEK-ERK inhibitor (U0126), and a PI3Kinase-Akt inhibitor (LY294002) remarkably attenuated TrkB, ERK, and Akt phosphorylation as well as increase of OPN mRNA expression in the HCEM cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	secreted phosphoprotein 1	Homo sapiens	218-221
24574497-5	2014	PlGF-mediated chemotaxis was inhibited by PI3K inhibitor (LY294002) and p38 MAPK inhibitor (SB203580), but not by ERK1/2 inhibitor (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	placental growth factor	Homo sapiens	0-4
23958920-0	2014	Chemical genomic screening identifies LY294002 as a modulator of glucocorticoid resistance in MLL-rearranged infant ALL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	lysine methyltransferase 2A	Homo sapiens	94-97
23958920-7	2014	Subsequent validation experiments demonstrated that indeed LY294002, and other known PI3K inhibitors, markedly sensitized otherwise resistant MLL-rearranged ALL cells to prednisolone in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	lysine methyltransferase 2A	Homo sapiens	142-145
24018979-8	2014	We further observed that thrombin markedly stimulated ATF2 or IkappaBalpha phosphorylation and NF-kappaB p65 translocation which were inhibited by Rottlerin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	coagulation factor II	Rattus norvegicus	25-33
24018979-8	2014	We further observed that thrombin markedly stimulated ATF2 or IkappaBalpha phosphorylation and NF-kappaB p65 translocation which were inhibited by Rottlerin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	activating transcription factor 2	Rattus norvegicus	54-58
24018979-8	2014	We further observed that thrombin markedly stimulated ATF2 or IkappaBalpha phosphorylation and NF-kappaB p65 translocation which were inhibited by Rottlerin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	NFKB inhibitor alpha	Rattus norvegicus	62-74
24018979-8	2014	We further observed that thrombin markedly stimulated ATF2 or IkappaBalpha phosphorylation and NF-kappaB p65 translocation which were inhibited by Rottlerin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	synaptotagmin 1	Rattus norvegicus	105-108
24018979-9	2014	Finally, thrombin stimulated in vivo binding of p65 to the MMP-9 promoter, which was reduced by pretreatment with Rottlerin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	coagulation factor II	Rattus norvegicus	9-17
24018979-9	2014	Finally, thrombin stimulated in vivo binding of p65 to the MMP-9 promoter, which was reduced by pretreatment with Rottlerin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	synaptotagmin 1	Rattus norvegicus	48-51
24018979-9	2014	Finally, thrombin stimulated in vivo binding of p65 to the MMP-9 promoter, which was reduced by pretreatment with Rottlerin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	matrix metallopeptidase 9	Rattus norvegicus	59-64
24022164-5	2014	In terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, the anti-apoptotic effect of GM-CSF (apoptotic population of approximately 8.17 %) on staurosporine-induced apoptosis of NPCs (31.09 %) was significantly blocked by LY294002, an inhibitor of PI3K signal (24.04 %).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	244-252	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	108-114
24529326-9	2014	The neuroprotective effects of neuregulin-1ss were prevented by treatment with Ly294002, an inhibitor of the phosphatidylinositol-3-kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	139-142
24774073-4	2014	beta-Hydroxy-beta-methylbutyrate up-regulated phosphorylation of Akt and mTOR, and these effects were completely abolished in the presence of PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	mechanistic target of rapamycin kinase	Homo sapiens	73-77
24774073-5	2014	beta-Hydroxy-beta-methylbutyrate also up-regulated FoxO1 and FoxO3a phosphorylation, and these changes were inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	forkhead box O1	Homo sapiens	51-56
24774073-5	2014	beta-Hydroxy-beta-methylbutyrate also up-regulated FoxO1 and FoxO3a phosphorylation, and these changes were inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	forkhead box O3	Homo sapiens	61-67
24449419-4	2014	LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked Cd2+-evoked Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CD2 antigen	Mus musculus	80-83
24347489-7	2014	Interestingly, blocking PI3K/Akt signaling pathway by LY294002 or Akt siRNA could remarkably inhibit the PAK1 activation and cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	29-32
24347489-7	2014	Interestingly, blocking PI3K/Akt signaling pathway by LY294002 or Akt siRNA could remarkably inhibit the PAK1 activation and cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	p21 (RAC1) activated kinase 1	Homo sapiens	105-109
24449419-4	2014	LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked Cd2+-evoked Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	34-63
24449419-4	2014	LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked Cd2+-evoked Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	92-95
24449419-5	2014	Correspondingly, LY294002 significantly repressed Cd2+-induced upregulation of MIP-2 and COX-2 in RAW264.7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	CD2 antigen	Mus musculus	50-53
24449419-5	2014	Correspondingly, LY294002 significantly repressed Cd2+-induced upregulation of MIP-2 and COX-2 in RAW264.7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	chemokine (C-X-C motif) ligand 2	Mus musculus	79-84
24449419-5	2014	Correspondingly, LY294002 significantly repressed Cd2+-induced upregulation of MIP-2 and COX-2 in RAW264.7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	cytochrome c oxidase II, mitochondrial	Mus musculus	89-94
24913674-2	2014	The DNA interstrand cross-linking agent BO-1509, a derivative of 3a-aza-cyclopenta[alpha]indene, was synthesized and combined with the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 to treat human lung cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	135-160
24763028-9	2014	Meanwhile, when LY294002, a specific AKT inhibitor, was added into the culture medium, the up-regulation of c-MYC expression was reduced, accompanied by the low rate of MSC growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	108-113
24913674-4	2014	We also found that LY294002 suppressed the induction of several DNA repair proteins by BO-1509 and inhibited the nuclear translocation of Rad51.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	RAD51 recombinase	Homo sapiens	138-143
24583134-4	2014	Furthermore, both Cyclosporin A (CsA, a specific NFAT inhibitor) and LY294002 (a Phosphoinositide 3-kinase (PI3K) inhibitor) significantly blocked IL-13-induced MUC5AC mRNA and protein production through the inhibition of NFAT3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	interleukin 13	Mus musculus	147-152
24583134-4	2014	Furthermore, both Cyclosporin A (CsA, a specific NFAT inhibitor) and LY294002 (a Phosphoinositide 3-kinase (PI3K) inhibitor) significantly blocked IL-13-induced MUC5AC mRNA and protein production through the inhibition of NFAT3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	161-167
24583134-4	2014	Furthermore, both Cyclosporin A (CsA, a specific NFAT inhibitor) and LY294002 (a Phosphoinositide 3-kinase (PI3K) inhibitor) significantly blocked IL-13-induced MUC5AC mRNA and protein production through the inhibition of NFAT3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4	Mus musculus	222-227
24508636-10	2014	Furthermore, IGF-I significantly stimulated both proliferation and migration of pTr cells, but these effects were blocked by P38 inhibitor (SB203580), U0126, MTOR inhibitor (rapamycin) and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	insulin like growth factor 1	Sus scrofa	13-18
24508636-9	2014	In the presence of the ERK1/2 MAPK inhibitor (U0126), IGF-I-induced AKT1 phosphorylation was not affected, whereas the PI3K inhibitor (LY294002) decreased IGF-I-induced phosphorylation of ERK1/2 and AKT1 proteins, and both the PI3K-AKT1 and ERK1/2 MAPK pathways were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	insulin like growth factor 1	Sus scrofa	155-160
24508636-9	2014	In the presence of the ERK1/2 MAPK inhibitor (U0126), IGF-I-induced AKT1 phosphorylation was not affected, whereas the PI3K inhibitor (LY294002) decreased IGF-I-induced phosphorylation of ERK1/2 and AKT1 proteins, and both the PI3K-AKT1 and ERK1/2 MAPK pathways were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	mitogen-activated protein kinase 3	Sus scrofa	188-194
24508636-9	2014	In the presence of the ERK1/2 MAPK inhibitor (U0126), IGF-I-induced AKT1 phosphorylation was not affected, whereas the PI3K inhibitor (LY294002) decreased IGF-I-induced phosphorylation of ERK1/2 and AKT1 proteins, and both the PI3K-AKT1 and ERK1/2 MAPK pathways were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Sus scrofa	199-203
24508636-9	2014	In the presence of the ERK1/2 MAPK inhibitor (U0126), IGF-I-induced AKT1 phosphorylation was not affected, whereas the PI3K inhibitor (LY294002) decreased IGF-I-induced phosphorylation of ERK1/2 and AKT1 proteins, and both the PI3K-AKT1 and ERK1/2 MAPK pathways were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Sus scrofa	199-203
24508636-9	2014	In the presence of the ERK1/2 MAPK inhibitor (U0126), IGF-I-induced AKT1 phosphorylation was not affected, whereas the PI3K inhibitor (LY294002) decreased IGF-I-induced phosphorylation of ERK1/2 and AKT1 proteins, and both the PI3K-AKT1 and ERK1/2 MAPK pathways were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	mitogen-activated protein kinase 3	Sus scrofa	188-194
24667766-6	2014	Treatment with NSC23766 or LY294002 significantly decreases LPS-induced TLR4 protein and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	toll-like receptor 4	Rattus norvegicus	72-76
24508636-9	2014	In the presence of the ERK1/2 MAPK inhibitor (U0126), IGF-I-induced AKT1 phosphorylation was not affected, whereas the PI3K inhibitor (LY294002) decreased IGF-I-induced phosphorylation of ERK1/2 and AKT1 proteins, and both the PI3K-AKT1 and ERK1/2 MAPK pathways were blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	278-286	mitogen-activated protein kinase 3	Sus scrofa	23-29
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	interleukin 1 beta	Homo sapiens	18-26
24647338-7	2014	Expression of p85beta was significantly more decreased under treatment with melatonin and thapsigargin or tunicamycin plus the PI3K inhibitors LY294002 or wortmannin than under treatment with only melatonin or a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	phosphoinositide-3-kinase regulatory subunit 2	Mus musculus	14-21
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	interleukin 6	Homo sapiens	28-32
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	tumor necrosis factor	Homo sapiens	54-63
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	AKT serine/threonine kinase 1	Homo sapiens	165-168
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	interleukin 1 beta	Homo sapiens	194-202
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	interleukin 6	Homo sapiens	204-208
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
24669186-10	2014	The production of IL-1beta, IL-6, and IL-8 induced by TNF-alpha was decreased by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6, and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	tumor necrosis factor	Homo sapiens	241-250
24757411-9	2014	The changes in cell proliferation and apoptosis were obvious in cells overexpressing FHIT which parallels that of treatment with LY294002, a potent inhibitor of phosphoinositide 3-kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	fragile histidine triad diadenosine triphosphatase	Homo sapiens	85-89
24757411-10	2014	Treatment with LY294002 further decreased the expression of survivin and Bcl-2 and increased caspase-3 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	BCL2 apoptosis regulator	Homo sapiens	73-78
24757411-10	2014	Treatment with LY294002 further decreased the expression of survivin and Bcl-2 and increased caspase-3 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	caspase 3	Homo sapiens	93-102
24569077-6	2014	The phosphorylation of Akt induced by clusterin was blocked by pretreatment with gallein or LY294002 but not with U73122, indicating that Gbetagamma released from the PTX-sensitive Gi protein complex activated PLC and PI3K/Akt signaling pathways separately.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	thymoma viral proto-oncogene 1	Mus musculus	23-26
24569077-6	2014	The phosphorylation of Akt induced by clusterin was blocked by pretreatment with gallein or LY294002 but not with U73122, indicating that Gbetagamma released from the PTX-sensitive Gi protein complex activated PLC and PI3K/Akt signaling pathways separately.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	clusterin	Mus musculus	38-47
24618279-6	2014	When the PI3K inhibitor LY294002 was injected (1 mg/25 g body weight) 1 h prior to the administration of LPS, the overall survival of the Tlr4-/- mice was 30%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	toll-like receptor 4	Mus musculus	138-142
24441870-7	2014	In addition, TNF-alpha-induced p42/p44 MAPK phosphorylation was reduced by AG1296 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	tumor necrosis factor	Homo sapiens	13-22
24441870-7	2014	In addition, TNF-alpha-induced p42/p44 MAPK phosphorylation was reduced by AG1296 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	cyclin dependent kinase 20	Homo sapiens	31-34
24441870-7	2014	In addition, TNF-alpha-induced p42/p44 MAPK phosphorylation was reduced by AG1296 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	interferon induced protein 44	Homo sapiens	35-38
24441870-7	2014	In addition, TNF-alpha-induced p42/p44 MAPK phosphorylation was reduced by AG1296 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	mitogen-activated protein kinase 3	Homo sapiens	39-43
24441870-8	2014	On the other hand, TNF-alpha could induce Akt and p42/p44 MAPK translocation from the cytosol into the nucleus, which was inhibited by AG490, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	tumor necrosis factor	Homo sapiens	19-28
24441870-8	2014	On the other hand, TNF-alpha could induce Akt and p42/p44 MAPK translocation from the cytosol into the nucleus, which was inhibited by AG490, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	AKT serine/threonine kinase 1	Homo sapiens	42-45
24441870-8	2014	On the other hand, TNF-alpha could induce Akt and p42/p44 MAPK translocation from the cytosol into the nucleus, which was inhibited by AG490, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	cyclin dependent kinase 20	Homo sapiens	50-53
24441870-8	2014	On the other hand, TNF-alpha could induce Akt and p42/p44 MAPK translocation from the cytosol into the nucleus, which was inhibited by AG490, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	interferon induced protein 44	Homo sapiens	54-57
24441870-8	2014	On the other hand, TNF-alpha could induce Akt and p42/p44 MAPK translocation from the cytosol into the nucleus, which was inhibited by AG490, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	mitogen-activated protein kinase 3	Homo sapiens	58-62
24441870-9	2014	Finally, we showed that TNF-alpha stimulated Elk-1 phosphorylation, which was reduced by LY294002 or PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	tumor necrosis factor	Homo sapiens	24-33
24441870-9	2014	Finally, we showed that TNF-alpha stimulated Elk-1 phosphorylation, which was reduced by LY294002 or PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	ETS transcription factor ELK1	Homo sapiens	45-50
24441870-10	2014	We also observed that TNF-alpha time dependently induced p300/Elk-1 and p300/Akt complex formation in HPAEpiCs, which was reduced by AG490, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	tumor necrosis factor	Homo sapiens	22-31
24441870-10	2014	We also observed that TNF-alpha time dependently induced p300/Elk-1 and p300/Akt complex formation in HPAEpiCs, which was reduced by AG490, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	E1A binding protein p300	Homo sapiens	57-61
24441870-10	2014	We also observed that TNF-alpha time dependently induced p300/Elk-1 and p300/Akt complex formation in HPAEpiCs, which was reduced by AG490, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	ETS transcription factor ELK1	Homo sapiens	62-67
24441870-10	2014	We also observed that TNF-alpha time dependently induced p300/Elk-1 and p300/Akt complex formation in HPAEpiCs, which was reduced by AG490, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	E1A binding protein p300	Homo sapiens	72-76
24618279-9	2014	Addition of LY294002 only significantly increased the O2- level in the lung and liver of the Tlr4-/- mice but not in the C57BL/6 mice following 500-mug LPS injection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	toll-like receptor 4	Mus musculus	93-97
24618279-11	2014	Notably, IL-1beta and IL-2 were significantly increased in Tlr4-/- mice but not in the C57BL/6 mice when the PI3K pathway was inhibited by LY294002 prior to LPS injection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	interleukin 1 beta	Mus musculus	9-17
24618279-11	2014	Notably, IL-1beta and IL-2 were significantly increased in Tlr4-/- mice but not in the C57BL/6 mice when the PI3K pathway was inhibited by LY294002 prior to LPS injection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	interleukin 2	Mus musculus	22-26
24441870-10	2014	We also observed that TNF-alpha time dependently induced p300/Elk-1 and p300/Akt complex formation in HPAEpiCs, which was reduced by AG490, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	AKT serine/threonine kinase 1	Homo sapiens	77-80
24441870-11	2014	The activity of cPLA2 protein upregulated by TNF-alpha was reflected on the PGE2 release, which was reduced by AG490, AG1296, LY294002, or PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	phospholipase A2 group IVA	Homo sapiens	16-21
24441870-11	2014	The activity of cPLA2 protein upregulated by TNF-alpha was reflected on the PGE2 release, which was reduced by AG490, AG1296, LY294002, or PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	tumor necrosis factor	Homo sapiens	45-54
24603487-6	2014	PTEN and p-Akt downregulation could be abrogated by both the PI3K inhibitor LY294002 and the mTOR inhibitor rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	phosphatase and tensin homolog	Homo sapiens	0-4
24451985-8	2014	The addition of LY294002, a PI3K inhibitor, decreased VEGF-induced phosphorylation of ERK1/2 and AKT1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	vascular endothelial growth factor A	Homo sapiens	54-58
24451985-8	2014	The addition of LY294002, a PI3K inhibitor, decreased VEGF-induced phosphorylation of ERK1/2 and AKT1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	mitogen-activated protein kinase 3	Homo sapiens	86-92
24451985-8	2014	The addition of LY294002, a PI3K inhibitor, decreased VEGF-induced phosphorylation of ERK1/2 and AKT1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	97-101
24451985-9	2014	Furthermore, VEGF significantly stimulated proliferation and migration of pTr cells, but these effects were blocked by SB203580, U0126, rapamycin, and LY294002, which inhibit p38 MAPK, ERK1/2, mTOR, and PI3K, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	vascular endothelial growth factor A	Homo sapiens	13-17
24451985-9	2014	Furthermore, VEGF significantly stimulated proliferation and migration of pTr cells, but these effects were blocked by SB203580, U0126, rapamycin, and LY294002, which inhibit p38 MAPK, ERK1/2, mTOR, and PI3K, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	mitogen-activated protein kinase 3	Homo sapiens	185-191
24451985-9	2014	Furthermore, VEGF significantly stimulated proliferation and migration of pTr cells, but these effects were blocked by SB203580, U0126, rapamycin, and LY294002, which inhibit p38 MAPK, ERK1/2, mTOR, and PI3K, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	mechanistic target of rapamycin kinase	Homo sapiens	193-197
24603487-6	2014	PTEN and p-Akt downregulation could be abrogated by both the PI3K inhibitor LY294002 and the mTOR inhibitor rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	11-14
24594691-7	2014	The radioresistance effect of hPEBP4 was reversed after given LY-294002 to inhibit Akt activation or antioxidant to abolish the ROS production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-71	phosphatidylethanolamine binding protein 4	Homo sapiens	30-36
24603539-7	2014	Additionally, the increase in proliferation and cyclin D1 expression induced by miR-21 overexpression was almost completely blocked by Ly294002, an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	cyclin D1	Homo sapiens	48-57
24603539-7	2014	Additionally, the increase in proliferation and cyclin D1 expression induced by miR-21 overexpression was almost completely blocked by Ly294002, an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	microRNA 21	Homo sapiens	80-86
24603539-7	2014	Additionally, the increase in proliferation and cyclin D1 expression induced by miR-21 overexpression was almost completely blocked by Ly294002, an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Homo sapiens	148-151
24594691-7	2014	The radioresistance effect of hPEBP4 was reversed after given LY-294002 to inhibit Akt activation or antioxidant to abolish the ROS production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-71	AKT serine/threonine kinase 1	Homo sapiens	83-86
24318646-10	2014	We further showed that PI3K inhibitor (LY294002), but not MEK inhibitor (U0126), could synergize with acrylamide (0.5 mM) to reduce the cell viability and neurite outgrowth in NGF- or FGF1-stimulated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	nerve growth factor	Rattus norvegicus	176-179
24487964-11	2014	TNF-alpha (5 ng/mL) caused activation of JNK, p38 MAPK, PI3K and Akt, whereas pretreatment with JNK inhibitor (SP600125), p38 MAPK inhibitor (SB202190) or PI-3K inhibitor (LY294002) significantly suppressed TNF-alpha-induced CXCL1 release from the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	tumor necrosis factor	Homo sapiens	0-9
24318646-10	2014	We further showed that PI3K inhibitor (LY294002), but not MEK inhibitor (U0126), could synergize with acrylamide (0.5 mM) to reduce the cell viability and neurite outgrowth in NGF- or FGF1-stimulated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	fibroblast growth factor 1	Rattus norvegicus	184-188
24649094-5	2014	LY294002 was used to inhibit PI3K-Akt signaling to determine the mechanism involved.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	34-37
24361597-6	2014	TNF-alpha-stimulated Akt phosphorylation was inhibited by genistein, PP1, AG1296, LY294002, or SH5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	tumor necrosis factor	Mus musculus	0-9
24361597-6	2014	TNF-alpha-stimulated Akt phosphorylation was inhibited by genistein, PP1, AG1296, LY294002, or SH5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	thymoma viral proto-oncogene 1	Mus musculus	21-24
24447935-7	2014	In contrast, combination treatment with PI3K inhibitors (LY294002 or wortmannin) and tamoxifen further decreased the TP expression and cell viability of NSCLC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	thymidine phosphorylase	Homo sapiens	117-119
24649094-7	2014	Moreover, blocking the PI3K/Akt pathway by LY294002 effectively eliminated 2-DG-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	28-31
24471974-14	2014	Moreover, PI3-K inhibitor-LY294002 (20 mg/kg) treatment partly attenuated AIT-elicited increases in Nrf2 levels and AMPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	100-104
24198040-8	2014	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (10 mumol/L) blocked the effects of IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	insulin like growth factor 1	Homo sapiens	96-101
24176823-11	2014	Pre-treating MDA-MB-231 cells with the specific PI3K inhibitor of LY294002 abolished the shear stress induced-Akt activation, and the expression of MMP-2, MMP-9, vascular endothelial growth factor (VEGF) and alphavbeta3 integrin were also down-regulated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	110-113
24176823-11	2014	Pre-treating MDA-MB-231 cells with the specific PI3K inhibitor of LY294002 abolished the shear stress induced-Akt activation, and the expression of MMP-2, MMP-9, vascular endothelial growth factor (VEGF) and alphavbeta3 integrin were also down-regulated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	matrix metallopeptidase 2	Homo sapiens	148-153
24176823-11	2014	Pre-treating MDA-MB-231 cells with the specific PI3K inhibitor of LY294002 abolished the shear stress induced-Akt activation, and the expression of MMP-2, MMP-9, vascular endothelial growth factor (VEGF) and alphavbeta3 integrin were also down-regulated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	matrix metallopeptidase 9	Homo sapiens	155-160
24176823-11	2014	Pre-treating MDA-MB-231 cells with the specific PI3K inhibitor of LY294002 abolished the shear stress induced-Akt activation, and the expression of MMP-2, MMP-9, vascular endothelial growth factor (VEGF) and alphavbeta3 integrin were also down-regulated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	vascular endothelial growth factor A	Homo sapiens	162-196
24176823-11	2014	Pre-treating MDA-MB-231 cells with the specific PI3K inhibitor of LY294002 abolished the shear stress induced-Akt activation, and the expression of MMP-2, MMP-9, vascular endothelial growth factor (VEGF) and alphavbeta3 integrin were also down-regulated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	vascular endothelial growth factor A	Homo sapiens	198-202
24293123-8	2014	In contrast, downregulation of Rap2a promoted glioma migration and invasion, and raised the phosphorylation level of AKT, whereas these effects were inhibited by PI3K-specific inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	RAP2A, member of RAS oncogene family	Homo sapiens	31-36
24293123-8	2014	In contrast, downregulation of Rap2a promoted glioma migration and invasion, and raised the phosphorylation level of AKT, whereas these effects were inhibited by PI3K-specific inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	AKT serine/threonine kinase 1	Homo sapiens	117-120
24289538-7	2014	SV-induced neuroprotection was attenuated by MLA or phosphatidylinositol-3-kinase (PI3K) antagonist LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	52-81
24424051-5	2014	I(-) stimulated Akt phosphorylation in a PI3K-dependent manner, because the use of PI3K inhibitors (wortmannin or 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one) abrogated the induction of I(-) effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-162	AKT serine/threonine kinase 1	Rattus norvegicus	16-19
24412598-7	2014	Interestingly, a high Ep-induced TLR5 expression was observed on the Caco2 cell surface, which was inhibited by an inhibitor of phosphoinositide3-kinase (PI3K), Ly294002, as well as a beta-adrenergic blocker, propranolol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	toll like receptor 5	Homo sapiens	33-37
24520260-8	2014	The inhibition of ERK, p38 kinase, phosphoinositide 3-kinase (PI3K) and Akt with PD98059, SB203580, LY294002 and triciribine, respectively, suppressed resveratrol-induced type II collagen and COX-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	cytochrome c oxidase subunit II	Oryctolagus cuniculus	192-197
25076559-7	2014	[3H]thymidine incorporation was blocked by lisuride, a 5-HT(2B) receptor antagonist, and also by LY-294002, a specific inhibitor of PI3K and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-106	AKT serine/threonine kinase 1	Homo sapiens	141-144
24476894-11	2014	The addition of LY294002 enabled to suppress Bcl-2 expression and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	BCL2 apoptosis regulator	Homo sapiens	45-50
24399305-4	2014	The combination of amrubicin and LY294002 enhanced Annexin V binding to cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	annexin A5	Mus musculus	51-60
25337568-8	2014	In addition, PEAL suppressed Akt activity and PEAL-induced apoptosis were significantly accentuated with Akt inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	105-108
24530793-7	2014	Blocking Akt/eNOS pathway activation by specific inhibitor LY294002 (10muL, 10mmol/L) or L-NIO (0.5mg/kg) partly reversed the protective effects of allicin and its anti-inflammatory activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Rattus norvegicus	9-12
24492281-8	2014	Thus, inhibition of the PI3K pathway by LY294002 attenuated LXRalpha upregulation and HCV replication mediated by lipid accumulation, showing an additive effect when combined with quercetin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	nuclear receptor subfamily 1 group H member 3	Homo sapiens	60-68
24533473-0	2014	The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	delta/notch like EGF repeat containing	Homo sapiens	63-66
24577313-10	2014	Furthermore, the HBx-induced increases in cyclin D1 expression and oval cell proliferation were completely abolished by treatment with either MEK inhibitor PD184352 or PI-3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	X protein	Hepatitis B virus	17-20
24577313-10	2014	Furthermore, the HBx-induced increases in cyclin D1 expression and oval cell proliferation were completely abolished by treatment with either MEK inhibitor PD184352 or PI-3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	cyclin D1	Homo sapiens	42-51
24472538-5	2014	Furthermore, inhibition of Stat3 led to enhancement of cell death induced by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	signal transducer and activator of transcription 3	Homo sapiens	27-32
24581171-5	2014	LY294002 (100 mg/kg), a potent inhibitor of Akt which reduced the levels of pAkt in HCCLM3 cell lines, was injected intraperitoneally into one group thrice weekly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	44-47
24361488-11	2014	Pretreatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), suppressed the phosphorylation of AKT and inhibited PCB29-pQ induced Nrf2/HO-1 activation, meanwhile, GSK-3beta expression was increased accordingly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	124-127
24361488-11	2014	Pretreatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), suppressed the phosphorylation of AKT and inhibited PCB29-pQ induced Nrf2/HO-1 activation, meanwhile, GSK-3beta expression was increased accordingly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	NFE2 like bZIP transcription factor 2	Homo sapiens	159-163
24361488-11	2014	Pretreatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), suppressed the phosphorylation of AKT and inhibited PCB29-pQ induced Nrf2/HO-1 activation, meanwhile, GSK-3beta expression was increased accordingly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	heme oxygenase 1	Homo sapiens	164-168
24361488-11	2014	Pretreatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), suppressed the phosphorylation of AKT and inhibited PCB29-pQ induced Nrf2/HO-1 activation, meanwhile, GSK-3beta expression was increased accordingly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	glycogen synthase kinase 3 beta	Homo sapiens	192-201
24533473-2	2014	Quantitative chemoproteomic profiling shows that LY294002 and LY303511, a close analogue devoid of PI3K activity, inhibit the BET bromodomain proteins BRD2, BRD3, and BRD4 that comprise a family of targets structurally unrelated to PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	delta/notch like EGF repeat containing	Homo sapiens	126-129
24533473-2	2014	Quantitative chemoproteomic profiling shows that LY294002 and LY303511, a close analogue devoid of PI3K activity, inhibit the BET bromodomain proteins BRD2, BRD3, and BRD4 that comprise a family of targets structurally unrelated to PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	bromodomain containing 2	Homo sapiens	151-155
24533473-2	2014	Quantitative chemoproteomic profiling shows that LY294002 and LY303511, a close analogue devoid of PI3K activity, inhibit the BET bromodomain proteins BRD2, BRD3, and BRD4 that comprise a family of targets structurally unrelated to PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	bromodomain containing 3	Homo sapiens	157-161
24533473-2	2014	Quantitative chemoproteomic profiling shows that LY294002 and LY303511, a close analogue devoid of PI3K activity, inhibit the BET bromodomain proteins BRD2, BRD3, and BRD4 that comprise a family of targets structurally unrelated to PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	bromodomain containing 4	Homo sapiens	167-171
24533473-4	2014	X-ray crystallography shows that the chromen-4-one scaffold represents a new bromodomain pharmacophore and establishes LY294002 as a dual kinase and BET-bromodomain inhibitor, whereas LY303511 exhibits anti-inflammatory and antiproliferative effects similar to the recently discovered BET inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	delta/notch like EGF repeat containing	Homo sapiens	149-152
24533473-4	2014	X-ray crystallography shows that the chromen-4-one scaffold represents a new bromodomain pharmacophore and establishes LY294002 as a dual kinase and BET-bromodomain inhibitor, whereas LY303511 exhibits anti-inflammatory and antiproliferative effects similar to the recently discovered BET inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	delta/notch like EGF repeat containing	Homo sapiens	285-288
24067903-10	2014	Furthermore, binding of FoxO3a with p27/Kip1 was markedly increased after 10 and 20 muM apigenin treatment resulting in G0/G1-phase cell cycle arrest, which was consistent with the effects elicited by PI3K/Akt inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	221-229	forkhead box O3	Mus musculus	24-30
24525337-5	2014	Inhibitors (LY294002, wortmannin, and deguelin) of phosphatidylinositol 3-kinases (PI3K) and AKT, but not inhibitors of MEK1/2, JNK, and p38-MAPK abolished the ActD-induced p53 expression in diverse cell types.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Homo sapiens	93-96
24520418-8	2014	Also, the PI3K specific inhibitor (LY294002) abolished CSF2-induced increases in p-ERK1/2 and p-MTOR proteins, as well as CSF2-induced phosphorylation of AKT1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	colony stimulating factor 2	Homo sapiens	55-59
24520418-8	2014	Also, the PI3K specific inhibitor (LY294002) abolished CSF2-induced increases in p-ERK1/2 and p-MTOR proteins, as well as CSF2-induced phosphorylation of AKT1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	mitogen-activated protein kinase 3	Homo sapiens	83-89
24520418-8	2014	Also, the PI3K specific inhibitor (LY294002) abolished CSF2-induced increases in p-ERK1/2 and p-MTOR proteins, as well as CSF2-induced phosphorylation of AKT1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	mechanistic target of rapamycin kinase	Sus scrofa	96-100
24520418-8	2014	Also, the PI3K specific inhibitor (LY294002) abolished CSF2-induced increases in p-ERK1/2 and p-MTOR proteins, as well as CSF2-induced phosphorylation of AKT1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	colony stimulating factor 2	Homo sapiens	122-126
24520418-8	2014	Also, the PI3K specific inhibitor (LY294002) abolished CSF2-induced increases in p-ERK1/2 and p-MTOR proteins, as well as CSF2-induced phosphorylation of AKT1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	154-158
24520418-10	2014	CSF2 significantly stimulated pTr cell proliferation and, U0126, rapamycin and LY294002 blocked this CSF2-induced proliferation of pTr cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	colony stimulating factor 2	Homo sapiens	101-105
24057571-4	2014	Treatment with LY294002, a PI3K inhibitor, suppressed CdCl2-induced ATF4 expression and Akt phosphorylation at Thr308 with little effect on phosphorylation of eukaryotic translation initiation factor 2 subunit alpha at Ser51.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	activating transcription factor 4	Homo sapiens	68-72
24057571-4	2014	Treatment with LY294002, a PI3K inhibitor, suppressed CdCl2-induced ATF4 expression and Akt phosphorylation at Thr308 with little effect on phosphorylation of eukaryotic translation initiation factor 2 subunit alpha at Ser51.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	88-91
24057571-6	2014	Suppression of CdCl2-induced ATF4 expression by LY294002 treatment was markedly blocked by cycloheximide, a translation inhibitor, but not by MG-132, a proteasome inhibitor, or actinomycin D, a transcription inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	activating transcription factor 4	Homo sapiens	29-33
24057571-9	2014	Conversely, SB216763, a GSK-3 inhibitor, markedly inhibited the potency of LY294002 to suppress CdCl2-induced ATF4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	activating transcription factor 4	Homo sapiens	110-114
24556678-8	2014	In contrast, although other phosphatidylinositol-3-kinase/Akt inhibitors (LY294002 and wortmannin) sensitized TRAIL-mediated apoptosis, c-FLIP(L) and Mcl-1 expressions were not altered.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	58-61
24556678-8	2014	In contrast, although other phosphatidylinositol-3-kinase/Akt inhibitors (LY294002 and wortmannin) sensitized TRAIL-mediated apoptosis, c-FLIP(L) and Mcl-1 expressions were not altered.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	TNF superfamily member 10	Homo sapiens	110-115
24556678-8	2014	In contrast, although other phosphatidylinositol-3-kinase/Akt inhibitors (LY294002 and wortmannin) sensitized TRAIL-mediated apoptosis, c-FLIP(L) and Mcl-1 expressions were not altered.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	CASP8 and FADD like apoptosis regulator	Homo sapiens	136-145
24556678-8	2014	In contrast, although other phosphatidylinositol-3-kinase/Akt inhibitors (LY294002 and wortmannin) sensitized TRAIL-mediated apoptosis, c-FLIP(L) and Mcl-1 expressions were not altered.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	150-155
24384683-8	2014	Suppression of phosphatidylinositol-3-kinase (PI3K)/Akt pathway by LY294002 restored chemosensitivity of Smad4-deficient cells to 5-FU.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Homo sapiens	52-55
24384683-8	2014	Suppression of phosphatidylinositol-3-kinase (PI3K)/Akt pathway by LY294002 restored chemosensitivity of Smad4-deficient cells to 5-FU.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	SMAD family member 4	Homo sapiens	105-110
24600206-7	2014	The role of the PI3K/Akt pathway in the insulin-triggered drug resistance was examined using the PI3K inhibitor LY294002 and the PI3K and mammalian target of rapamycin dual inhibitor BEZ-235.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	insulin	Homo sapiens	40-47
24600206-10	2014	Nevertheless, the protective effect of insulin was abolished by the PI3K and mTOR dual inhibitor BEZ-235 or the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	insulin	Homo sapiens	39-46
24524196-5	2014	Pharmaceutical inhibition of PI3K with LY294002 significantly blocked the Wnt5a-induced activation of Akt (p-Ser473) and decreased Wnt5a-induced cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	Wnt family member 5A	Homo sapiens	74-79
24524196-5	2014	Pharmaceutical inhibition of PI3K with LY294002 significantly blocked the Wnt5a-induced activation of Akt (p-Ser473) and decreased Wnt5a-induced cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	102-105
24524196-5	2014	Pharmaceutical inhibition of PI3K with LY294002 significantly blocked the Wnt5a-induced activation of Akt (p-Ser473) and decreased Wnt5a-induced cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	Wnt family member 5A	Homo sapiens	131-136
24067903-10	2014	Furthermore, binding of FoxO3a with p27/Kip1 was markedly increased after 10 and 20 muM apigenin treatment resulting in G0/G1-phase cell cycle arrest, which was consistent with the effects elicited by PI3K/Akt inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	221-229	cyclin-dependent kinase inhibitor 1B	Mus musculus	36-39
24067903-10	2014	Furthermore, binding of FoxO3a with p27/Kip1 was markedly increased after 10 and 20 muM apigenin treatment resulting in G0/G1-phase cell cycle arrest, which was consistent with the effects elicited by PI3K/Akt inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	221-229	cyclin-dependent kinase inhibitor 1B	Mus musculus	40-44
24248461-8	2014	Furthermore, pretreatment with the ERK inhibitor PD98059 and the PI3K inhibitor LY294002 abolished leptin-induced RANKL expression and blocked the promotion of ALP activity of CVSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	leptin	Mus musculus	99-105
23910058-0	2014	In vitro regulation of hepatocellular carcinoma cell viability, apoptosis, invasion, and AEG-1 expression by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	metadherin	Homo sapiens	89-94
23910058-2	2014	SUBJECTS AND METHODS: This study investigated the effects of PI3K inhibitor, LY294002, on suppression of astrocyte elevated gene-1 (AEG-1) and regulation of HCC cell viability, apoptosis, and invasion in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	metadherin	Homo sapiens	105-130
23910058-2	2014	SUBJECTS AND METHODS: This study investigated the effects of PI3K inhibitor, LY294002, on suppression of astrocyte elevated gene-1 (AEG-1) and regulation of HCC cell viability, apoptosis, and invasion in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	metadherin	Homo sapiens	132-137
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	metadherin	Homo sapiens	47-52
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	65-68
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	glycogen synthase kinase 3 beta	Homo sapiens	73-81
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cyclin D1	Homo sapiens	117-125
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cyclin dependent kinase 4	Homo sapiens	127-131
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	vascular endothelial growth factor A	Homo sapiens	133-137
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	BCL2 apoptosis regulator	Homo sapiens	142-146
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	165-168
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	173-178
24248461-8	2014	Furthermore, pretreatment with the ERK inhibitor PD98059 and the PI3K inhibitor LY294002 abolished leptin-induced RANKL expression and blocked the promotion of ALP activity of CVSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	114-119
24283667-12	2014	The PI3K inhibitor LY294002 reduced epinephrine-induced release of VWF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	von Willebrand factor	Homo sapiens	67-70
24296130-5	2014	Phosphatidylinositol-3-kinase/Akt and MAPKs were also significantly activated by genipin, and Akt and MAPKs inhibitors (PD98059, SB20358, SP600125, and LY294002) inhibited genipin-induced COX-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	thymoma viral proto-oncogene 1	Mus musculus	30-33
24296130-5	2014	Phosphatidylinositol-3-kinase/Akt and MAPKs were also significantly activated by genipin, and Akt and MAPKs inhibitors (PD98059, SB20358, SP600125, and LY294002) inhibited genipin-induced COX-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	thymoma viral proto-oncogene 1	Mus musculus	94-97
24296130-5	2014	Phosphatidylinositol-3-kinase/Akt and MAPKs were also significantly activated by genipin, and Akt and MAPKs inhibitors (PD98059, SB20358, SP600125, and LY294002) inhibited genipin-induced COX-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	prostaglandin-endoperoxide synthase 2	Mus musculus	188-193
24248991-8	2014	In addition, C. pneumoniae infection-induced Rac1 activation in the VSMCs was blocked by LY294002 (25 microM), an inhibitor of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	Rac family small GTPase 1	Rattus norvegicus	45-49
24333105-8	2014	Furthermore, inhibition of PI3K/AKT signaling by LY294002 partially prevents ICT-induced nuclear translocation of Nrf2 and GCL transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	32-35
24333105-8	2014	Furthermore, inhibition of PI3K/AKT signaling by LY294002 partially prevents ICT-induced nuclear translocation of Nrf2 and GCL transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
24333105-8	2014	Furthermore, inhibition of PI3K/AKT signaling by LY294002 partially prevents ICT-induced nuclear translocation of Nrf2 and GCL transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	germ cell-less 2, spermatogenesis associated	Homo sapiens	123-126
23818293-5	2014	Overexpression of ETAR in SW480 cells significantly increased cell survival against cisplatin, cell invasion, and matrix metalloproteinase (MMP)-2 expression, which was strengthened by exogenous ET-1 and abolished by selective ETAR antagonist BQ123 and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	300-308	endothelin receptor type A	Homo sapiens	18-22
23818293-5	2014	Overexpression of ETAR in SW480 cells significantly increased cell survival against cisplatin, cell invasion, and matrix metalloproteinase (MMP)-2 expression, which was strengthened by exogenous ET-1 and abolished by selective ETAR antagonist BQ123 and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	300-308	endothelin receptor type A	Homo sapiens	227-231
24378649-12	2014	Blockade of the PI3K/Akt signaling pathway by LY294002 abrogates the protection caused by thrombin treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	21-24
24197118-6	2014	Ccr5 signaling was dependent on the mitogen-activated protein kinase kinase (Map2k) but not the phosphoinositide 3-kinase (Pi3k) pathway because treatment with U0126 inhibited upregulation of Erdr1, but treatment with LY294002 increased the expression by 3.44 +- 0.92-fold (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	chemokine (C-C motif) receptor 5	Mus musculus	0-4
24378649-12	2014	Blockade of the PI3K/Akt signaling pathway by LY294002 abrogates the protection caused by thrombin treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	coagulation factor II, thrombin	Homo sapiens	90-98
24486459-3	2014	Further, the PI3K/Akt inhibitor, LY294002 diminished the expression of LPS-stimulated iNOS and COX-2 genes by suppressing NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	thymoma viral proto-oncogene 1	Mus musculus	18-21
24337632-7	2014	LY294002 induced cell cycle arrest at G0/G1 in SNU-449 and Mahlavu cells by decreasing expression of CDK2, CDK4, CycD1, CycD3, CycE, CycA and increasing expression of p21 and p27 as well; it also caused a decrease in the E2F1 transcriptional activity through declining phosphorylated Rb.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin dependent kinase 2	Homo sapiens	101-105
24486459-3	2014	Further, the PI3K/Akt inhibitor, LY294002 diminished the expression of LPS-stimulated iNOS and COX-2 genes by suppressing NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	nitric oxide synthase 2, inducible	Mus musculus	86-90
24486459-3	2014	Further, the PI3K/Akt inhibitor, LY294002 diminished the expression of LPS-stimulated iNOS and COX-2 genes by suppressing NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	prostaglandin-endoperoxide synthase 2	Mus musculus	95-100
24486459-3	2014	Further, the PI3K/Akt inhibitor, LY294002 diminished the expression of LPS-stimulated iNOS and COX-2 genes by suppressing NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	122-131
24231000-8	2014	Further, blockage of phosphoinositide 3-kinase/Akt kinase with their specific inhibitors, LY294002 and Akt 1/2 kinase inhibitor, significantly reduced TCDD-enhanced proliferation of HAPI microglial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 1	Rattus norvegicus	47-50
24337632-7	2014	LY294002 induced cell cycle arrest at G0/G1 in SNU-449 and Mahlavu cells by decreasing expression of CDK2, CDK4, CycD1, CycD3, CycE, CycA and increasing expression of p21 and p27 as well; it also caused a decrease in the E2F1 transcriptional activity through declining phosphorylated Rb.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin dependent kinase 4	Homo sapiens	107-111
24337632-7	2014	LY294002 induced cell cycle arrest at G0/G1 in SNU-449 and Mahlavu cells by decreasing expression of CDK2, CDK4, CycD1, CycD3, CycE, CycA and increasing expression of p21 and p27 as well; it also caused a decrease in the E2F1 transcriptional activity through declining phosphorylated Rb.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	H3 histone pseudogene 16	Homo sapiens	167-170
24337632-7	2014	LY294002 induced cell cycle arrest at G0/G1 in SNU-449 and Mahlavu cells by decreasing expression of CDK2, CDK4, CycD1, CycD3, CycE, CycA and increasing expression of p21 and p27 as well; it also caused a decrease in the E2F1 transcriptional activity through declining phosphorylated Rb.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	dynactin subunit 6	Homo sapiens	175-178
24337632-7	2014	LY294002 induced cell cycle arrest at G0/G1 in SNU-449 and Mahlavu cells by decreasing expression of CDK2, CDK4, CycD1, CycD3, CycE, CycA and increasing expression of p21 and p27 as well; it also caused a decrease in the E2F1 transcriptional activity through declining phosphorylated Rb.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	E2F transcription factor 1	Homo sapiens	221-225
24311782-9	2014	Thus, the PI3K inhibitor LY294002 or knockdown of Akt or Fyn expression abrogated the impact of IER3 deficiency on Nrf2 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
24316214-8	2014	alpha-MSH-mediated S6K1 activation and pro-survival effect against H2O2 was inhibited by Akt inhibitors (perifosine, MK-2206 and LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	proopiomelanocortin	Homo sapiens	0-9
24157854-7	2014	The selective PI3K inhibitor LY294002 compromised EA-induced neuroprotective effects and reduced the elevation of p-Akt, p-Bad and Bcl-2 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
24157854-7	2014	The selective PI3K inhibitor LY294002 compromised EA-induced neuroprotective effects and reduced the elevation of p-Akt, p-Bad and Bcl-2 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	BCL2, apoptosis regulator	Rattus norvegicus	131-136
24316214-8	2014	alpha-MSH-mediated S6K1 activation and pro-survival effect against H2O2 was inhibited by Akt inhibitors (perifosine, MK-2206 and LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	AKT serine/threonine kinase 1	Homo sapiens	89-92
24269237-9	2014	To explore the potential mechanism, we investigated the effect of DT-13 on Akt and MAPK pathways and found that DT-13 was involved in Akt signaling confirmed by using PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	AKT serine/threonine kinase 1	Homo sapiens	134-137
24398984-6	2014	However, the enhancement of migration of fibroblasts accelerated by AF-MSC-hypoCM was inhibited by SB505124 and LY294002, inhibitors of TGF-beta/SMAD2 and PI3K/AKT, suggesting that AF-MSC-hypoCM-enhanced wound healing is mediated by the activation of TGF-beta/SMAD2 and PI3K/AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	transforming growth factor beta 1	Homo sapiens	136-144
24398984-6	2014	However, the enhancement of migration of fibroblasts accelerated by AF-MSC-hypoCM was inhibited by SB505124 and LY294002, inhibitors of TGF-beta/SMAD2 and PI3K/AKT, suggesting that AF-MSC-hypoCM-enhanced wound healing is mediated by the activation of TGF-beta/SMAD2 and PI3K/AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	SMAD family member 2	Homo sapiens	145-150
24398984-6	2014	However, the enhancement of migration of fibroblasts accelerated by AF-MSC-hypoCM was inhibited by SB505124 and LY294002, inhibitors of TGF-beta/SMAD2 and PI3K/AKT, suggesting that AF-MSC-hypoCM-enhanced wound healing is mediated by the activation of TGF-beta/SMAD2 and PI3K/AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Homo sapiens	160-163
24398984-6	2014	However, the enhancement of migration of fibroblasts accelerated by AF-MSC-hypoCM was inhibited by SB505124 and LY294002, inhibitors of TGF-beta/SMAD2 and PI3K/AKT, suggesting that AF-MSC-hypoCM-enhanced wound healing is mediated by the activation of TGF-beta/SMAD2 and PI3K/AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	transforming growth factor beta 1	Homo sapiens	251-259
24398984-6	2014	However, the enhancement of migration of fibroblasts accelerated by AF-MSC-hypoCM was inhibited by SB505124 and LY294002, inhibitors of TGF-beta/SMAD2 and PI3K/AKT, suggesting that AF-MSC-hypoCM-enhanced wound healing is mediated by the activation of TGF-beta/SMAD2 and PI3K/AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	SMAD family member 2	Homo sapiens	260-265
24398984-6	2014	However, the enhancement of migration of fibroblasts accelerated by AF-MSC-hypoCM was inhibited by SB505124 and LY294002, inhibitors of TGF-beta/SMAD2 and PI3K/AKT, suggesting that AF-MSC-hypoCM-enhanced wound healing is mediated by the activation of TGF-beta/SMAD2 and PI3K/AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Homo sapiens	275-278
24574749-7	2014	There were significant reductions in the protein levels of Skp2/Cks1 and p27(kip1) (from nuclear lysate) after the treatment of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	S-phase kinase associated protein 2	Homo sapiens	59-63
24574749-7	2014	There were significant reductions in the protein levels of Skp2/Cks1 and p27(kip1) (from nuclear lysate) after the treatment of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	CDC28 protein kinase regulatory subunit 1B pseudogene 7	Homo sapiens	64-68
24574749-7	2014	There were significant reductions in the protein levels of Skp2/Cks1 and p27(kip1) (from nuclear lysate) after the treatment of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	dynactin subunit 6	Homo sapiens	73-76
24574749-7	2014	There were significant reductions in the protein levels of Skp2/Cks1 and p27(kip1) (from nuclear lysate) after the treatment of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	cyclin dependent kinase inhibitor 1B	Homo sapiens	77-81
24269237-9	2014	To explore the potential mechanism, we investigated the effect of DT-13 on Akt and MAPK pathways and found that DT-13 was involved in Akt signaling confirmed by using PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	AKT serine/threonine kinase 1	Homo sapiens	134-137
24144893-7	2014	In BXPC-3 cells, knockdown of Par-4 expression induces EMT and CDDP insensitivity, however, these effects were blocked by inhibition of PI3K/Akt pathway using LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	pro-apoptotic WT1 regulator	Homo sapiens	30-35
24144893-7	2014	In BXPC-3 cells, knockdown of Par-4 expression induces EMT and CDDP insensitivity, however, these effects were blocked by inhibition of PI3K/Akt pathway using LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	AKT serine/threonine kinase 1	Homo sapiens	141-144
24144893-11	2014	Inhibition of PI3K/Akt pathway using LY294002 reversed CDDP resistance in Par-4 siRNA-transfected BXPC-3 tumors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	19-22
24144893-11	2014	Inhibition of PI3K/Akt pathway using LY294002 reversed CDDP resistance in Par-4 siRNA-transfected BXPC-3 tumors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	pro-apoptotic WT1 regulator	Homo sapiens	74-79
24982891-5	2014	Reduced c-FLIPL expression was observed in LNCaP cells treated with LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-77	CASP8 and FADD like apoptosis regulator	Homo sapiens	8-15
24332015-3	2014	Elastase-treated Raw cells produced increased p308 and significant amounts of matrix metalloproteinase 9 (MMP-9), and these effects were suppressed by LY294002 treatment, a known AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	matrix metallopeptidase 9	Mus musculus	78-104
24332015-3	2014	Elastase-treated Raw cells produced increased p308 and significant amounts of matrix metalloproteinase 9 (MMP-9), and these effects were suppressed by LY294002 treatment, a known AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	matrix metallopeptidase 9	Mus musculus	106-111
24332015-3	2014	Elastase-treated Raw cells produced increased p308 and significant amounts of matrix metalloproteinase 9 (MMP-9), and these effects were suppressed by LY294002 treatment, a known AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	thymoma viral proto-oncogene 1	Mus musculus	179-182
24332015-6	2014	LY294002 also inhibited elastase-induced p308 formation more in female smooth muscle cells than in males, and the corresponding cell media had less pro-MMP-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	matrix metallopeptidase 9	Mus musculus	148-157
25478604-8	2014	A PI3K-antagonist treatment with LY294002 or CGRP1-37/Ad.Akt(K179M) co-treatment alleviated the CGRP-increased caspase activity and -decrements in SOD-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	superoxide dismutase 3	Homo sapiens	147-152
24942858-7	2014	Inhibition studies using LY294002 revealed the requirement of PI3K/Akt pathway for CB12-II-stimulated NF-kappaB activation in association with MMP-13 production.Pretreatment with anti-CD44 antibody reversed the inhibitory effects of HA on CB12-II-induced production of MMP-13 and activation of Akt and NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	CD44 molecule (Indian blood group)	Homo sapiens	184-188
24030871-7	2014	RAPA markedly inhibited cell proliferation, induced G1 cell cycle arrest, and reduced phosphorylation of p70 S6 protein kinase (p70S6K) and 4E-BP1 in GC cells, particularly when used in combination with LY294002 or TSA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	ribosomal protein S6 kinase B1	Homo sapiens	128-134
24184006-8	2014	The Akt inhibitor LY294002 attenuated the allicin-induced increase in eNOS expression and phosphorylation, whereas the ERK inhibitor PD98059 had opposite effects on the expression of iNOS and eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	4-7
24063814-9	2014	Both total MCP-1 levels and secreted MCP-1 levels were attenuated during the response to Cyr61 stimulation by pretreatment with integrin alphanubeta3-blocking antibodies, a FAK inhibitor (PF573228), a PI3K inhibitor (LY294002), and an Akt inhibitor (A6730).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	chemokine (C-C motif) ligand 2	Mus musculus	37-42
24063814-9	2014	Both total MCP-1 levels and secreted MCP-1 levels were attenuated during the response to Cyr61 stimulation by pretreatment with integrin alphanubeta3-blocking antibodies, a FAK inhibitor (PF573228), a PI3K inhibitor (LY294002), and an Akt inhibitor (A6730).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	cellular communication network factor 1	Mus musculus	89-94
25059120-11	2014	Knockdown of Akt2 using siRNAs or the PI3K inhibitor Ly294002 inhibited TGF-beta1-induced phosphorylation of GSK3beta and expression of Snail1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	transforming growth factor beta 1	Homo sapiens	72-81
25059120-11	2014	Knockdown of Akt2 using siRNAs or the PI3K inhibitor Ly294002 inhibited TGF-beta1-induced phosphorylation of GSK3beta and expression of Snail1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	glycogen synthase kinase 3 beta	Homo sapiens	109-117
25034177-5	2014	Finally we examined the involvement of PI3K/Akt/GSK3beta signaling by treating the cells (untransfected or transfected with expression vector encoding SGK1) with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	AKT serine/threonine kinase 1	Rattus norvegicus	44-47
25059120-11	2014	Knockdown of Akt2 using siRNAs or the PI3K inhibitor Ly294002 inhibited TGF-beta1-induced phosphorylation of GSK3beta and expression of Snail1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	snail family transcriptional repressor 1	Homo sapiens	136-142
25034177-5	2014	Finally we examined the involvement of PI3K/Akt/GSK3beta signaling by treating the cells (untransfected or transfected with expression vector encoding SGK1) with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	glycogen synthase kinase 3 beta	Rattus norvegicus	48-56
24571890-2	2014	Here, we investigated whether PSMA serves as a novel regulator of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling by employing PSMA knockdown model and PI3K pharmacological inhibitor (LY294002) in LNCaP prostate cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	191-199	folate hydrolase 1	Homo sapiens	30-34
25034177-5	2014	Finally we examined the involvement of PI3K/Akt/GSK3beta signaling by treating the cells (untransfected or transfected with expression vector encoding SGK1) with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	151-155
25034177-10	2014	Addition of LY294002 revealed that the action of SGK1 in suppressing apoptosis was mediated by the PI3K/Akt/GSK3beta pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	49-53
25059120-8	2014	Importantly, TGF-beta1 treatment decreased zona occludins 1 (ZO-1) and E-cadherin (epithelial markers) expression, increased fibronectin and vimentin (mesenchymal makers) expression, which were prevented by Ly294002 (the inhibitor of PI3K) or small interfering RNA (siAkt2), suggesting that Akt2 mediated TGF-beta1-induced EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	transforming growth factor beta 1	Homo sapiens	13-22
24484591-6	2014	Additionally, LY294002, a PI3K-Akt inhibitor, could block the differentiation of U937 cells induced by UA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	31-34
24571890-10	2014	However, LY294002 administration significantly reduced the expression of p-Akt (Ser473) in all the three groups.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	73-78
24571890-11	2014	The results of immunocytochemistry further confirmed that PSMA knockdown or LY294002 treatment was associated with p-Akt (Ser473) down-regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	115-120
24867506-8	2014	Furthermore, geniposide also inhibited the phosphorylation of downstream target GSK3beta, and this effect was counteracted by preincubation with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	glycogen synthase kinase 3 beta	Rattus norvegicus	80-88
24295494-9	2014	Inhibition of Akt by RNAi or LY294002 treatment may overcome miR-221/222 induced radioresistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	microRNA 221	Mus musculus	61-68
24206109-8	2014	Furthermore, blocking ERK, PI3K and NFkappaB signaling pathways with U0126, LY294002 and pyrrolidine dithiocarbamate, respectively, significantly inhibited the mGluR2/3-mediated restorative effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	mitogen-activated protein kinase 1	Homo sapiens	22-25
24206109-8	2014	Furthermore, blocking ERK, PI3K and NFkappaB signaling pathways with U0126, LY294002 and pyrrolidine dithiocarbamate, respectively, significantly inhibited the mGluR2/3-mediated restorative effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	nuclear factor kappa B subunit 1	Homo sapiens	36-44
24206109-8	2014	Furthermore, blocking ERK, PI3K and NFkappaB signaling pathways with U0126, LY294002 and pyrrolidine dithiocarbamate, respectively, significantly inhibited the mGluR2/3-mediated restorative effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	160-166
25479544-7	2014	We further found that the PI3K/Akt inhibitor LY294002 down-regulated BCRP expression, hence showing that the Akt pathway is involved in the regulation of BCRP expression but not in its localization in these lung cancer cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	31-34
25479544-7	2014	We further found that the PI3K/Akt inhibitor LY294002 down-regulated BCRP expression, hence showing that the Akt pathway is involved in the regulation of BCRP expression but not in its localization in these lung cancer cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	69-73
25479544-7	2014	We further found that the PI3K/Akt inhibitor LY294002 down-regulated BCRP expression, hence showing that the Akt pathway is involved in the regulation of BCRP expression but not in its localization in these lung cancer cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	109-112
25479544-7	2014	We further found that the PI3K/Akt inhibitor LY294002 down-regulated BCRP expression, hence showing that the Akt pathway is involved in the regulation of BCRP expression but not in its localization in these lung cancer cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	154-158
24283363-8	2014	The decrease in SM22alpha and alpha-SM actin mRNA levels induced by PDGF-BB was markedly and reproducibly blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	transgelin	Rattus norvegicus	16-25
24202965-11	2014	Furthermore, Akt inhibition by LY294002 treatment restored the CDDP cytotoxicity that was suppressed by FOXO1 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	13-16
24817900-12	2014	Both Gfr alpha 1 siRNAs and LY294002 treatments held back YC extract"s stimulation effects on mRNA and protein expression of Oct-4 and Plzf and consequently inhibited the proliferation of GC-1 spg cells induced by YC extract.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	125-130
24817900-12	2014	Both Gfr alpha 1 siRNAs and LY294002 treatments held back YC extract"s stimulation effects on mRNA and protein expression of Oct-4 and Plzf and consequently inhibited the proliferation of GC-1 spg cells induced by YC extract.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	zinc finger and BTB domain containing 16	Mus musculus	135-139
24202965-11	2014	Furthermore, Akt inhibition by LY294002 treatment restored the CDDP cytotoxicity that was suppressed by FOXO1 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	forkhead box O1	Homo sapiens	104-109
25530759-4	2014	These effects disappeared when AKT expression was downregulated with PI3K/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Rattus norvegicus	31-34
24291391-5	2014	In addition, we demonstrated that a specific NF-kappaB inhibitor PDTC and a selective PI3K/Akt inhibitor, LY294002 effectively attenuated the expression of LPS-stimulated iNOS and COX-2 mRNA, while LY294002 suppressed LPS-induced NF-kappaB activity, suggesting that TIA attenuates the expression of these proinflammatory genes by suppressing PI3K/Akt-mediated NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	thymoma viral proto-oncogene 1	Mus musculus	91-94
24291391-5	2014	In addition, we demonstrated that a specific NF-kappaB inhibitor PDTC and a selective PI3K/Akt inhibitor, LY294002 effectively attenuated the expression of LPS-stimulated iNOS and COX-2 mRNA, while LY294002 suppressed LPS-induced NF-kappaB activity, suggesting that TIA attenuates the expression of these proinflammatory genes by suppressing PI3K/Akt-mediated NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	nitric oxide synthase 2, inducible	Mus musculus	171-175
24291391-5	2014	In addition, we demonstrated that a specific NF-kappaB inhibitor PDTC and a selective PI3K/Akt inhibitor, LY294002 effectively attenuated the expression of LPS-stimulated iNOS and COX-2 mRNA, while LY294002 suppressed LPS-induced NF-kappaB activity, suggesting that TIA attenuates the expression of these proinflammatory genes by suppressing PI3K/Akt-mediated NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	prostaglandin-endoperoxide synthase 2	Mus musculus	180-185
24291391-5	2014	In addition, we demonstrated that a specific NF-kappaB inhibitor PDTC and a selective PI3K/Akt inhibitor, LY294002 effectively attenuated the expression of LPS-stimulated iNOS and COX-2 mRNA, while LY294002 suppressed LPS-induced NF-kappaB activity, suggesting that TIA attenuates the expression of these proinflammatory genes by suppressing PI3K/Akt-mediated NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	thymoma viral proto-oncogene 1	Mus musculus	347-350
24291391-5	2014	In addition, we demonstrated that a specific NF-kappaB inhibitor PDTC and a selective PI3K/Akt inhibitor, LY294002 effectively attenuated the expression of LPS-stimulated iNOS and COX-2 mRNA, while LY294002 suppressed LPS-induced NF-kappaB activity, suggesting that TIA attenuates the expression of these proinflammatory genes by suppressing PI3K/Akt-mediated NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	198-206	nitric oxide synthase 2, inducible	Mus musculus	171-175
25530759-4	2014	These effects disappeared when AKT expression was downregulated with PI3K/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
24057122-5	2014	We also found that rhEPO increased the expression of phosphorylated AKT, and the antiapoptotic role of rhEPO could be abolished by phosphoinositide 3-kinase (PI3K)/AKT inhibitor LY294002 or SH-5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	AKT serine/threonine kinase 1	Homo sapiens	68-71
24646622-6	2014	To further confirm this finding, the autophagy pathway was activated by lentiviral mediated beclin-1 delivery and the PI3K/Akt pathway was inhibited by a pharmacological inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	AKT serine/threonine kinase 1	Rattus norvegicus	123-126
24212403-13	2014	The anti-apoptotic effects of CTRP3 were blocked by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt signaling pathway with the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	81-106
24212403-13	2014	The anti-apoptotic effects of CTRP3 were blocked by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt signaling pathway with the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
24808633-6	2014	Moreover, MT-III-induced COX-2 protein expression and PGE2 release were attenuated by pretreatment of macrophages with SB202190, and Ly294002, and H-7-dihydro compounds, indicating the involvement of p38MAPK, PI3K, and PKC pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	metallothionein 3	Homo sapiens	10-16
24808633-6	2014	Moreover, MT-III-induced COX-2 protein expression and PGE2 release were attenuated by pretreatment of macrophages with SB202190, and Ly294002, and H-7-dihydro compounds, indicating the involvement of p38MAPK, PI3K, and PKC pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	prostaglandin-endoperoxide synthase 2	Homo sapiens	25-30
24057122-5	2014	We also found that rhEPO increased the expression of phosphorylated AKT, and the antiapoptotic role of rhEPO could be abolished by phosphoinositide 3-kinase (PI3K)/AKT inhibitor LY294002 or SH-5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	AKT serine/threonine kinase 1	Homo sapiens	164-167
24072614-0	2014	LY294002 and Rapamycin promote coxsackievirus-induced cytopathic effect and apoptosis via inhibition of PI3K/AKT/mTOR signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	109-112
24218165-3	2014	In the present work, we aimed to study whether glioblastoma cells can be sensitized by cisplatin combined with LY294002 (LY), which is an inhibitor of PI3K-related family (ATM, ATR, DNA-PK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	ATM serine/threonine kinase	Homo sapiens	172-175
24072614-0	2014	LY294002 and Rapamycin promote coxsackievirus-induced cytopathic effect and apoptosis via inhibition of PI3K/AKT/mTOR signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	113-117
24072614-6	2014	We further show that LY294002 and Rapamycin, the inhibitor of PI3K and mTOR respectively, promote CVB3-induced CPE and apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	mechanistic target of rapamycin kinase	Homo sapiens	71-75
24218165-3	2014	In the present work, we aimed to study whether glioblastoma cells can be sensitized by cisplatin combined with LY294002 (LY), which is an inhibitor of PI3K-related family (ATM, ATR, DNA-PK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	ATR serine/threonine kinase	Homo sapiens	177-180
24218165-3	2014	In the present work, we aimed to study whether glioblastoma cells can be sensitized by cisplatin combined with LY294002 (LY), which is an inhibitor of PI3K-related family (ATM, ATR, DNA-PK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	182-188
24218165-3	2014	In the present work, we aimed to study whether glioblastoma cells can be sensitized by cisplatin combined with LY294002 (LY), which is an inhibitor of PI3K-related family (ATM, ATR, DNA-PK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-113	ATM serine/threonine kinase	Homo sapiens	172-175
24218165-3	2014	In the present work, we aimed to study whether glioblastoma cells can be sensitized by cisplatin combined with LY294002 (LY), which is an inhibitor of PI3K-related family (ATM, ATR, DNA-PK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-113	ATR serine/threonine kinase	Homo sapiens	177-180
24218165-3	2014	In the present work, we aimed to study whether glioblastoma cells can be sensitized by cisplatin combined with LY294002 (LY), which is an inhibitor of PI3K-related family (ATM, ATR, DNA-PK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-113	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	182-188
25110549-6	2014	Atorvastatin activated Nrf 2 via the PI3K/Akt pathway and thereby promoted Nrf 2 translocation from the cytoplasm to the nucleus in bone marrow-derived dendritic cells (BMDCs), a process that was reversed by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	227-235	NFE2 like bZIP transcription factor 2	Homo sapiens	75-80
26168133-9	2014	Inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt with LY294002 (LY) and p38 kinase with SB203580 (SB), respectively, decreased berberine-induced p53 and p21 expression and restored cell proliferation and expression of cyclin B1, cdc2, cdc25c, and pRb cell cycle progression proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	51-54
24247826-5	2014	Insulin promoted the proliferation of MG63 cells in a time- and dose-dependent manner, however, this insulin induced proliferation was significantly inhibited by transfection of shRNA targeted to the LIMK1 gene, as well as by the PI3K inhibitor LY294002, but not by the mitogen-activated protein kinase (MAPK) inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	insulin	Homo sapiens	0-7
24247826-5	2014	Insulin promoted the proliferation of MG63 cells in a time- and dose-dependent manner, however, this insulin induced proliferation was significantly inhibited by transfection of shRNA targeted to the LIMK1 gene, as well as by the PI3K inhibitor LY294002, but not by the mitogen-activated protein kinase (MAPK) inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	insulin	Homo sapiens	101-108
24376781-8	2013	Moreover, addition of the PI3K inhibitor, LY-294002, significantly (p&lt;0.05) decreases upregulation of IL-10 and arginase-1, suggesting involvement of the PI3K pathway in M2 macrophage polarization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-51	interleukin 10	Homo sapiens	105-110
24364919-7	2013	While LY294002 treatment markedly abolished miR-494-inducing Akt activation, HIF-1alpha and HO-1 increase under both normoxic and hypoxic conditions (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	microRNA 494	Homo sapiens	44-51
24364919-7	2013	While LY294002 treatment markedly abolished miR-494-inducing Akt activation, HIF-1alpha and HO-1 increase under both normoxic and hypoxic conditions (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	AKT serine/threonine kinase 1	Homo sapiens	61-64
24364919-7	2013	While LY294002 treatment markedly abolished miR-494-inducing Akt activation, HIF-1alpha and HO-1 increase under both normoxic and hypoxic conditions (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
24339862-5	2013	Interestingly, both PTEN rescue and phosphoinositide 3-kinase (PI3K) inhibitor LY294002 treatment increase the PLZF expression in prostate cancer cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	zinc finger and BTB domain containing 16	Homo sapiens	111-115
24393155-6	2014	Selected cultures were pretreated with phosphatidylinositol 3-kinase/protein kinase B (AKT) inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	AKT serine/threonine kinase 1	Rattus norvegicus	87-90
24393155-13	2014	LY294002 decreased cytoplasmic AKT phosphorylation and inhibited the protection effects of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	31-34
24351811-9	2013	The mitogen-activated kinase/ERK kinase (MEK) inhibitor U0126 and the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 significantly decreased neurite outgrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	70-99
24376419-9	2013	Moreover, the effect of Rd on GLT-1 expression and glutamate uptake can be abolished by PI3K/AKT agonist LY294002 or ERK1/2 inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	solute carrier family 1 member 2	Rattus norvegicus	30-35
24376419-9	2013	Moreover, the effect of Rd on GLT-1 expression and glutamate uptake can be abolished by PI3K/AKT agonist LY294002 or ERK1/2 inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
24376781-8	2013	Moreover, addition of the PI3K inhibitor, LY-294002, significantly (p&lt;0.05) decreases upregulation of IL-10 and arginase-1, suggesting involvement of the PI3K pathway in M2 macrophage polarization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-51	arginase 1	Homo sapiens	115-125
24312554-12	2013	The effects of BK PC were abrogated by the B2 receptor antagonist HOE140, the Akt and eNOS antagonists LY294002 and L-NAME, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	AKT serine/threonine kinase 1	Homo sapiens	78-81
24304619-11	2013	PI3K inhibitor LY294002 was used to explore the signal pathways of integrin alpha6 in HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	integrin subunit alpha 6	Homo sapiens	67-82
24304619-14	2013	P-ERK and p-AKT were reduced by shRNA targeting integrin alpha6 and PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	0-5
23948751-0	2013	Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	caspase 8	Homo sapiens	48-55
23948751-2	2013	Therefore, PI3K inhibitor LY294002 (LY) and MEK1/2 inhibitor PD98059 (PD) are used to sensitize many types of cancer cell lines to chemotherapeutic agents, where AKT and ERK pathways are over activated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	162-165
23948751-2	2013	Therefore, PI3K inhibitor LY294002 (LY) and MEK1/2 inhibitor PD98059 (PD) are used to sensitize many types of cancer cell lines to chemotherapeutic agents, where AKT and ERK pathways are over activated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	mitogen-activated protein kinase 1	Homo sapiens	170-173
24219292-5	2013	LY294002, an inhibitor of PI3K-Akt pathway, and rapamycin, inhibitor of mammalian target of rapamycin (mTOR), significantly reversed the effect of 15(S)-HETE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	31-34
24077806-7	2013	Decreasing the ATG7 protein level using specific small interference RNA (siRNA) and pretreating with phosphatidylinositol 3-phosphate kinase blockers, wortmannin and LY294002, inhibited puncta formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	autophagy related 7	Rattus norvegicus	15-19
24184018-5	2013	Consistently we found that CGRP-triggered CREB activation can be blocked by both PI3K inhibitor LY294002 and NMDAR antagonists MK801 and D-AP5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	calcitonin-related polypeptide alpha	Rattus norvegicus	27-31
24012499-9	2013	This effect was attenuated by treatment with the pharmacological inhibitors U0126, LY294002 and rapamycin, which selectively block the activation of ERK1/2, Akt and mTOR, respectively, and siRNAs directed against ERK1/2, Akt and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	mitogen-activated protein kinase 3	Homo sapiens	149-155
24012499-9	2013	This effect was attenuated by treatment with the pharmacological inhibitors U0126, LY294002 and rapamycin, which selectively block the activation of ERK1/2, Akt and mTOR, respectively, and siRNAs directed against ERK1/2, Akt and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	AKT serine/threonine kinase 1	Homo sapiens	157-160
24012499-9	2013	This effect was attenuated by treatment with the pharmacological inhibitors U0126, LY294002 and rapamycin, which selectively block the activation of ERK1/2, Akt and mTOR, respectively, and siRNAs directed against ERK1/2, Akt and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	mechanistic target of rapamycin kinase	Homo sapiens	165-169
24012499-9	2013	This effect was attenuated by treatment with the pharmacological inhibitors U0126, LY294002 and rapamycin, which selectively block the activation of ERK1/2, Akt and mTOR, respectively, and siRNAs directed against ERK1/2, Akt and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	mitogen-activated protein kinase 3	Homo sapiens	213-219
24012499-9	2013	This effect was attenuated by treatment with the pharmacological inhibitors U0126, LY294002 and rapamycin, which selectively block the activation of ERK1/2, Akt and mTOR, respectively, and siRNAs directed against ERK1/2, Akt and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	AKT serine/threonine kinase 1	Homo sapiens	221-224
24012499-9	2013	This effect was attenuated by treatment with the pharmacological inhibitors U0126, LY294002 and rapamycin, which selectively block the activation of ERK1/2, Akt and mTOR, respectively, and siRNAs directed against ERK1/2, Akt and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	mechanistic target of rapamycin kinase	Homo sapiens	229-233
24001613-7	2013	In support of these observations, Nir1 binding to CCL18 promoted lung metastasis and LY294002 could inhibit it in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	PITPNM family member 3	Homo sapiens	34-38
24001613-7	2013	In support of these observations, Nir1 binding to CCL18 promoted lung metastasis and LY294002 could inhibit it in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	C-C motif chemokine ligand 18	Homo sapiens	50-55
24184018-3	2013	We demonstrate that suppression of endogenous PI3K/Akt activity with a potent PI3K inhibitor LY294002 reverses CYP-induced phosphorylation of CREB, however, it has no effect on CYP-induced phosphorylation of NR1 at Ser(897) and Ser(896); conversely, inhibition of NMDAR in vivo with MK801 fails to block CYP-induced Akt activation but significantly attenuates CYP-induced CREB phosphorylation in lumbosacral spinal cord.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Rattus norvegicus	51-54
24184018-3	2013	We demonstrate that suppression of endogenous PI3K/Akt activity with a potent PI3K inhibitor LY294002 reverses CYP-induced phosphorylation of CREB, however, it has no effect on CYP-induced phosphorylation of NR1 at Ser(897) and Ser(896); conversely, inhibition of NMDAR in vivo with MK801 fails to block CYP-induced Akt activation but significantly attenuates CYP-induced CREB phosphorylation in lumbosacral spinal cord.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	cAMP responsive element binding protein 1	Rattus norvegicus	142-146
24184018-3	2013	We demonstrate that suppression of endogenous PI3K/Akt activity with a potent PI3K inhibitor LY294002 reverses CYP-induced phosphorylation of CREB, however, it has no effect on CYP-induced phosphorylation of NR1 at Ser(897) and Ser(896); conversely, inhibition of NMDAR in vivo with MK801 fails to block CYP-induced Akt activation but significantly attenuates CYP-induced CREB phosphorylation in lumbosacral spinal cord.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	208-211
24184018-5	2013	Consistently we found that CGRP-triggered CREB activation can be blocked by both PI3K inhibitor LY294002 and NMDAR antagonists MK801 and D-AP5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	cAMP responsive element binding protein 1	Rattus norvegicus	42-46
24184018-6	2013	However, CGRP-triggered Akt activation cannot be blocked by MK801 or D-AP5; vice versa, LY294002 pretreatment that suppresses the Akt activity fails to reverse CGRP-elicited NR1 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Rattus norvegicus	130-133
23735482-9	2013	Moreover, quercetin arrested Src, PI3K, PDK1 and Akt activation in a time- and dose-dependent manner, which was comparable to PP2 and LY294002 inhibition of Src, PI3K/Akt and iNOS expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	Rous sarcoma oncogene	Mus musculus	157-160
24184018-3	2013	We demonstrate that suppression of endogenous PI3K/Akt activity with a potent PI3K inhibitor LY294002 reverses CYP-induced phosphorylation of CREB, however, it has no effect on CYP-induced phosphorylation of NR1 at Ser(897) and Ser(896); conversely, inhibition of NMDAR in vivo with MK801 fails to block CYP-induced Akt activation but significantly attenuates CYP-induced CREB phosphorylation in lumbosacral spinal cord.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Rattus norvegicus	316-319
24184018-3	2013	We demonstrate that suppression of endogenous PI3K/Akt activity with a potent PI3K inhibitor LY294002 reverses CYP-induced phosphorylation of CREB, however, it has no effect on CYP-induced phosphorylation of NR1 at Ser(897) and Ser(896); conversely, inhibition of NMDAR in vivo with MK801 fails to block CYP-induced Akt activation but significantly attenuates CYP-induced CREB phosphorylation in lumbosacral spinal cord.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	cAMP responsive element binding protein 1	Rattus norvegicus	372-376
23812937-6	2013	Inhibition of the PI3K/Akt pathway with wortmannin and Ly294002 caused a significant reduction in the expression of cytoplasmic wild-type survivin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	23-26
23735482-9	2013	Moreover, quercetin arrested Src, PI3K, PDK1 and Akt activation in a time- and dose-dependent manner, which was comparable to PP2 and LY294002 inhibition of Src, PI3K/Akt and iNOS expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	thymoma viral proto-oncogene 1	Mus musculus	167-170
24100802-10	2013	Additionally, PDGFBB stimulation increased VCAM-1 expression of BM-MSCs, which could be inhibited by LY294002, SB203580 and BAY11-7082.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	vascular cell adhesion molecule 1	Rattus norvegicus	43-49
24142192-8	2013	A further increase in LC3-II levels was observed in cells treated with both palmitate and 50 microM PI3K/Akt inhibitor LY294002 compared with cells treated with palmitate alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	thymoma viral proto-oncogene 1	Mus musculus	105-108
24277465-8	2013	Treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 could arrest cells growth and diminish Emi1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	13-42
24277465-8	2013	Treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 could arrest cells growth and diminish Emi1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	F-box protein 5	Homo sapiens	108-112
23973310-6	2013	In addition, the significant increases in RhoA activity and PKB phosphorylation after MS administration were observed, which were partly inhibited by N-2-mercaptopropionyl glycine (MPG) or C3 exoenzyme or LY294002 pretreatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	ras homolog family member A	Rattus norvegicus	42-46
23867319-7	2013	Pretreatment of liver donors with PI3K inhibitor (LY294002) disrupted Akt/HIF-1A signaling and recreated hepatocellular damage in otherwise IR-resistant Keap1 HKO transplants.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	thymoma viral proto-oncogene 1	Mus musculus	70-73
23867319-7	2013	Pretreatment of liver donors with PI3K inhibitor (LY294002) disrupted Akt/HIF-1A signaling and recreated hepatocellular damage in otherwise IR-resistant Keap1 HKO transplants.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	hypoxia inducible factor 1, alpha subunit	Mus musculus	74-80
23867319-7	2013	Pretreatment of liver donors with PI3K inhibitor (LY294002) disrupted Akt/HIF-1A signaling and recreated hepatocellular damage in otherwise IR-resistant Keap1 HKO transplants.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	kelch-like ECH-associated protein 1	Mus musculus	153-158
24002703-5	2013	Doxycycline (10 mug/mL), an inhibitor of MMP, markedly attenuated the hypoxia-induced downregulation of Cx43 protein expression at 6 h. The hypoxia-induced decrease in Cx43 protein expression was significantly reversed by U0126 (10 muM), a MEK/ERK1/2 inhibitor, at 6 and 12 h; LY294002 (30 muM), a PI3K inhibitor, downregulated Cx43 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	matrix metallopeptidase 9	Homo sapiens	41-44
24002703-5	2013	Doxycycline (10 mug/mL), an inhibitor of MMP, markedly attenuated the hypoxia-induced downregulation of Cx43 protein expression at 6 h. The hypoxia-induced decrease in Cx43 protein expression was significantly reversed by U0126 (10 muM), a MEK/ERK1/2 inhibitor, at 6 and 12 h; LY294002 (30 muM), a PI3K inhibitor, downregulated Cx43 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	gap junction protein alpha 1	Homo sapiens	104-108
24002703-5	2013	Doxycycline (10 mug/mL), an inhibitor of MMP, markedly attenuated the hypoxia-induced downregulation of Cx43 protein expression at 6 h. The hypoxia-induced decrease in Cx43 protein expression was significantly reversed by U0126 (10 muM), a MEK/ERK1/2 inhibitor, at 6 and 12 h; LY294002 (30 muM), a PI3K inhibitor, downregulated Cx43 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	gap junction protein alpha 1	Homo sapiens	168-172
24002703-5	2013	Doxycycline (10 mug/mL), an inhibitor of MMP, markedly attenuated the hypoxia-induced downregulation of Cx43 protein expression at 6 h. The hypoxia-induced decrease in Cx43 protein expression was significantly reversed by U0126 (10 muM), a MEK/ERK1/2 inhibitor, at 6 and 12 h; LY294002 (30 muM), a PI3K inhibitor, downregulated Cx43 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	gap junction protein alpha 1	Homo sapiens	168-172
24002703-6	2013	Hypoxia-induced MMP-9 activation was inhibited by treatment with LY294002, U0126, and, most especially, U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	matrix metallopeptidase 9	Homo sapiens	16-21
24321071-9	2013	Further, leptin promoted migration and invasion of MCF-7 cells, which were attenuated by the JAK/STAT inhibitor AG490 (50 mumol/L), and the PI3K/AKT inhibitor LY294002 (10 mumol/L) (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	leptin	Homo sapiens	9-15
24321071-9	2013	Further, leptin promoted migration and invasion of MCF-7 cells, which were attenuated by the JAK/STAT inhibitor AG490 (50 mumol/L), and the PI3K/AKT inhibitor LY294002 (10 mumol/L) (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	AKT serine/threonine kinase 1	Homo sapiens	145-148
24225433-11	2013	Pre-treatment with NF-kappaB (SC514) and PI3K/Akt (LY294002) inhibitor partially abrogated CCL5 mRNA and protein expression levels as opposed to untreated controls after HIV-1 Vpr transfection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	46-49
24312381-9	2013	Pretreatment with LY-294002 (5 microM) and PD98059 (10 microM) blocked the FABP4-induced proliferation and migration of HCASMCs, suggesting the activation of a kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-27	fatty acid binding protein 4	Homo sapiens	75-80
24303055-6	2013	Further study showed that application of NGF to the nerve terminals of the ganglion-nerve two-compartmented preparation enhanced BDNF expression in the DRG neuronal soma; which was reduced by pre-treatment of the ganglia with the PI3K inhibitor LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	brain-derived neurotrophic factor	Rattus norvegicus	129-133
24260155-7	2013	The pretreatment of cells with specific ER inhibitors or PI3K/Akt (ICI182,780 and LY294002) increased Nrf2, HO-1, and NQO1 protein, impaired nuclear translocation of HA-Nrf2, and decreased ARE-luciferase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	62-65
24260155-7	2013	The pretreatment of cells with specific ER inhibitors or PI3K/Akt (ICI182,780 and LY294002) increased Nrf2, HO-1, and NQO1 protein, impaired nuclear translocation of HA-Nrf2, and decreased ARE-luciferase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
24260155-7	2013	The pretreatment of cells with specific ER inhibitors or PI3K/Akt (ICI182,780 and LY294002) increased Nrf2, HO-1, and NQO1 protein, impaired nuclear translocation of HA-Nrf2, and decreased ARE-luciferase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	heme oxygenase 1	Homo sapiens	108-112
24260155-7	2013	The pretreatment of cells with specific ER inhibitors or PI3K/Akt (ICI182,780 and LY294002) increased Nrf2, HO-1, and NQO1 protein, impaired nuclear translocation of HA-Nrf2, and decreased ARE-luciferase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	NAD(P)H quinone dehydrogenase 1	Homo sapiens	118-122
24260155-7	2013	The pretreatment of cells with specific ER inhibitors or PI3K/Akt (ICI182,780 and LY294002) increased Nrf2, HO-1, and NQO1 protein, impaired nuclear translocation of HA-Nrf2, and decreased ARE-luciferase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173
23973924-10	2013	The TLR4/PRL and PRL/NF-kappaB co-localization was also corroborated by immunofluorescence and the involvement of PI3K/Akt signaling in lactotroph proliferation and IL-6 release was revealed through the PI3K inhibitor Ly-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-227	toll like receptor 4	Homo sapiens	4-8
23973924-10	2013	The TLR4/PRL and PRL/NF-kappaB co-localization was also corroborated by immunofluorescence and the involvement of PI3K/Akt signaling in lactotroph proliferation and IL-6 release was revealed through the PI3K inhibitor Ly-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-227	prolactin	Homo sapiens	9-12
23973924-10	2013	The TLR4/PRL and PRL/NF-kappaB co-localization was also corroborated by immunofluorescence and the involvement of PI3K/Akt signaling in lactotroph proliferation and IL-6 release was revealed through the PI3K inhibitor Ly-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-227	prolactin	Homo sapiens	17-20
24228711-6	2013	Further analysis by using siRNA targeting the AKT-1 and the PI3K pathway inhibitor Ly294002 revealed that the AKT-1 siRNA reduced the WT1 expression effectively in A549 cells, and the same result was observed in Ly294002 treated cells, indicating that DDP treatment could down regulate WT1 expression through the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	AKT serine/threonine kinase 1	Homo sapiens	110-115
24228711-6	2013	Further analysis by using siRNA targeting the AKT-1 and the PI3K pathway inhibitor Ly294002 revealed that the AKT-1 siRNA reduced the WT1 expression effectively in A549 cells, and the same result was observed in Ly294002 treated cells, indicating that DDP treatment could down regulate WT1 expression through the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	WT1 transcription factor	Homo sapiens	134-137
24228711-6	2013	Further analysis by using siRNA targeting the AKT-1 and the PI3K pathway inhibitor Ly294002 revealed that the AKT-1 siRNA reduced the WT1 expression effectively in A549 cells, and the same result was observed in Ly294002 treated cells, indicating that DDP treatment could down regulate WT1 expression through the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	WT1 transcription factor	Homo sapiens	286-289
24228711-6	2013	Further analysis by using siRNA targeting the AKT-1 and the PI3K pathway inhibitor Ly294002 revealed that the AKT-1 siRNA reduced the WT1 expression effectively in A549 cells, and the same result was observed in Ly294002 treated cells, indicating that DDP treatment could down regulate WT1 expression through the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	AKT serine/threonine kinase 1	Homo sapiens	46-51
24228711-6	2013	Further analysis by using siRNA targeting the AKT-1 and the PI3K pathway inhibitor Ly294002 revealed that the AKT-1 siRNA reduced the WT1 expression effectively in A549 cells, and the same result was observed in Ly294002 treated cells, indicating that DDP treatment could down regulate WT1 expression through the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	AKT serine/threonine kinase 1	Homo sapiens	110-115
24228711-6	2013	Further analysis by using siRNA targeting the AKT-1 and the PI3K pathway inhibitor Ly294002 revealed that the AKT-1 siRNA reduced the WT1 expression effectively in A549 cells, and the same result was observed in Ly294002 treated cells, indicating that DDP treatment could down regulate WT1 expression through the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	WT1 transcription factor	Homo sapiens	134-137
24228711-6	2013	Further analysis by using siRNA targeting the AKT-1 and the PI3K pathway inhibitor Ly294002 revealed that the AKT-1 siRNA reduced the WT1 expression effectively in A549 cells, and the same result was observed in Ly294002 treated cells, indicating that DDP treatment could down regulate WT1 expression through the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	WT1 transcription factor	Homo sapiens	286-289
24228711-6	2013	Further analysis by using siRNA targeting the AKT-1 and the PI3K pathway inhibitor Ly294002 revealed that the AKT-1 siRNA reduced the WT1 expression effectively in A549 cells, and the same result was observed in Ly294002 treated cells, indicating that DDP treatment could down regulate WT1 expression through the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	AKT serine/threonine kinase 1	Homo sapiens	46-49
24055520-7	2013	When the cells were treated with IGF-II and PI3-kinase/Akt inhibitors, such as LY294002, wortmannin, or Akt inhibitor IV, STS expression induced by IGF-II was significantly blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	insulin like growth factor 2	Homo sapiens	33-39
24055520-7	2013	When the cells were treated with IGF-II and PI3-kinase/Akt inhibitors, such as LY294002, wortmannin, or Akt inhibitor IV, STS expression induced by IGF-II was significantly blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	55-58
24055520-7	2013	When the cells were treated with IGF-II and PI3-kinase/Akt inhibitors, such as LY294002, wortmannin, or Akt inhibitor IV, STS expression induced by IGF-II was significantly blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	insulin like growth factor 2	Homo sapiens	148-154
24225433-11	2013	Pre-treatment with NF-kappaB (SC514) and PI3K/Akt (LY294002) inhibitor partially abrogated CCL5 mRNA and protein expression levels as opposed to untreated controls after HIV-1 Vpr transfection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	C-C motif chemokine ligand 5	Homo sapiens	91-95
24265694-7	2013	During the process, we further identified whether PI3K/AKT signaling pathway is involved through the adjunction of LY294002 (a specific phosphatidylinositide-3-kinase (PI3K) inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	AKT serine/threonine kinase 1	Rattus norvegicus	55-58
24227918-10	2013	Pretreatment with LY294002 and PD98059 abolished apelin-induced activation of Akt and Erk, proliferation, and collagen I expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	apelin	Homo sapiens	49-55
24244375-8	2013	Pre-treatment with SC514 (NF-kappaB inhibitor), LY294002 (PI3K inhibitor), AG490 (JAK2 inhibitor) and Janex-1 (JAK3 inhibitor) showed partial reduction of the Tat-mediated induction of CCL5 suggesting involvement of JAK, PI3K/Akt and NF-kappaB in CCL5 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	C-C motif chemokine ligand 5	Homo sapiens	185-189
24244375-8	2013	Pre-treatment with SC514 (NF-kappaB inhibitor), LY294002 (PI3K inhibitor), AG490 (JAK2 inhibitor) and Janex-1 (JAK3 inhibitor) showed partial reduction of the Tat-mediated induction of CCL5 suggesting involvement of JAK, PI3K/Akt and NF-kappaB in CCL5 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	226-229
24244375-8	2013	Pre-treatment with SC514 (NF-kappaB inhibitor), LY294002 (PI3K inhibitor), AG490 (JAK2 inhibitor) and Janex-1 (JAK3 inhibitor) showed partial reduction of the Tat-mediated induction of CCL5 suggesting involvement of JAK, PI3K/Akt and NF-kappaB in CCL5 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	nuclear factor kappa B subunit 1	Homo sapiens	234-243
24244375-8	2013	Pre-treatment with SC514 (NF-kappaB inhibitor), LY294002 (PI3K inhibitor), AG490 (JAK2 inhibitor) and Janex-1 (JAK3 inhibitor) showed partial reduction of the Tat-mediated induction of CCL5 suggesting involvement of JAK, PI3K/Akt and NF-kappaB in CCL5 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	C-C motif chemokine ligand 5	Homo sapiens	247-251
24227918-10	2013	Pretreatment with LY294002 and PD98059 abolished apelin-induced activation of Akt and Erk, proliferation, and collagen I expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	78-81
24227918-10	2013	Pretreatment with LY294002 and PD98059 abolished apelin-induced activation of Akt and Erk, proliferation, and collagen I expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	mitogen-activated protein kinase 1	Homo sapiens	86-89
24227918-11	2013	Apelin-induced migration was partially blocked by pretreatment with LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	apelin	Homo sapiens	0-6
23921150-9	2013	Pretreatment of cells with the ERK inhibitor PD98059, PI3K inhibitor LY294002, and GHSR-siRNA blocked the ghrelin-induced activation of ERK and AKT, respectively; however, ghrelin did not stimulate the phosphorylation of p38 or JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	ghrelin	Mus musculus	106-113
24029593-5	2013	The reduction of iNOS/NO and HMGB1 expression by THI-28 was significantly reversed by silencing HO-1 RNA or treatment with SB203580, a p38 MAPK inhibitor, or LY294002, a PI3K inhibitor in LPS-activated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	nitric oxide synthase 2, inducible	Mus musculus	17-21
23836025-5	2013	The heat stimulation led to a significant amplification in the phosphorylation of AMP-activated protein kinase (AMPK) and Akt, and treatment with compound C, wortmannin, or LY294002 partially blocked the thermal effect on muscle glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	AKT serine/threonine kinase 1	Rattus norvegicus	122-125
24200059-9	2013	Western blotting showed that the expressions of ZO-1, occludin and claudin-5 were significantly reduced after 2.5 mumol/L lead treatment (P&lt;0.05); the phosphorylation levels of ERK1/2, JNK, p38, AKT473 and AKT308 were elevated significantly (P&lt;0.05); ERK1/2 inhibitor PD98059 and PI3K inhibitor LY294002 reversed the lead effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	301-309	tight junction protein 1	Homo sapiens	48-52
24200059-9	2013	Western blotting showed that the expressions of ZO-1, occludin and claudin-5 were significantly reduced after 2.5 mumol/L lead treatment (P&lt;0.05); the phosphorylation levels of ERK1/2, JNK, p38, AKT473 and AKT308 were elevated significantly (P&lt;0.05); ERK1/2 inhibitor PD98059 and PI3K inhibitor LY294002 reversed the lead effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	301-309	mitogen-activated protein kinase 3	Homo sapiens	180-186
24168056-12	2013	LY294002 and PD98059 inhibited the EMT of SMMC7721-H and Huh7-H cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	MIR7-3 host gene	Homo sapiens	57-61
24229686-11	2013	LY294002, a specific inhibitor of PI3K, could effectively inhibit the increase of Akt and GSK3beta after preconditioning treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	82-85
24229686-11	2013	LY294002, a specific inhibitor of PI3K, could effectively inhibit the increase of Akt and GSK3beta after preconditioning treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	90-98
23757055-6	2013	In contrast, NAC and a PI3K inhibitor, LY-294002, reversed the down-regulation of osteogenic markers and the up-regulation of adipogenic markers as well as the activation of Akt under high glucose.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	AKT serine/threonine kinase 1	Rattus norvegicus	174-177
23907017-6	2013	Conversely, cholesterol induced hypertrophic characteristic features such as increase in cellular surface area, and the expression of beta-MHC mRNA is markedly inhibited by LY294002, a PI3K kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	myosin heavy chain 7	Rattus norvegicus	134-142
24083989-9	2013	Since apelin-36 increased the level of phosphorylated Akt after H/I injury, we treated neonates with a specific PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	54-57
24083989-10	2013	We found that LY294002 decreased the phosphorylated Akt level and attenuated protective effects of apelin-36 on apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	52-55
24055799-8	2013	Additionally, PDGF-induced up-regulation of KCa3.1 and down-regulation of BSM contractile marker proteins were regulated by the ERK inhibitor U0126 and the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	potassium calcium-activated channel subfamily N member 4	Homo sapiens	44-50
24055799-8	2013	Additionally, PDGF-induced up-regulation of KCa3.1 and down-regulation of BSM contractile marker proteins were regulated by the ERK inhibitor U0126 and the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Homo sapiens	156-159
24624877-11	2013	And, the expression of ILK in LY294002 group was slightly lower than that of black control group, but there was no statistical difference.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	integrin linked kinase	Homo sapiens	23-26
24176848-2	2013	We report here a novel mechanism underlying the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitizing activity of the small molecule LY303511, an inactive analog of the phosphoinositide 3-kinase inhibitor inhibitor LY294002, in HeLa cells that are refractory to TRAIL-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	237-245	TNF superfamily member 10	Homo sapiens	48-103
24176848-2	2013	We report here a novel mechanism underlying the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitizing activity of the small molecule LY303511, an inactive analog of the phosphoinositide 3-kinase inhibitor inhibitor LY294002, in HeLa cells that are refractory to TRAIL-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	237-245	TNF superfamily member 10	Homo sapiens	105-110
24176848-3	2013	On the basis of the fact that LY303511 is derived from LY294002, itself derived from quercetin, and earlier findings indicating that quercetin and LY294002 affected Hsp27 expression, we investigated whether LY303511 sensitized cancer cells to TRAIL via a conserved inhibitory effect on Hsp27.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	heat shock protein family B (small) member 1	Homo sapiens	165-170
24205274-6	2013	Ly294002 (a phosphatidylinositol-3-kinase [PI3K] inhibitor) or rapamycin (an mTOR inhibitor) blocked the induction of cellular senescence markers suggesting roles for PI3K and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	176-180
24152443-4	2013	In this study, using two NGF-responsive rodent cell model systems, PC12h cells and F11 cells, we found the delta opioid neuropeptide [D-Ala2, D-Leu5] enkephalin (DADLE)-mediated neuroprotective effect could be blocked by pharmacological reagents: the delta opioid antagonist naltrindole, PI3K inhibitor LY294002, MAPK inhibitor PD98059, and Trk inhibitor K252a, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	303-311	nerve growth factor	Rattus norvegicus	25-28
24152443-4	2013	In this study, using two NGF-responsive rodent cell model systems, PC12h cells and F11 cells, we found the delta opioid neuropeptide [D-Ala2, D-Leu5] enkephalin (DADLE)-mediated neuroprotective effect could be blocked by pharmacological reagents: the delta opioid antagonist naltrindole, PI3K inhibitor LY294002, MAPK inhibitor PD98059, and Trk inhibitor K252a, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	303-311	proenkephalin	Rattus norvegicus	150-160
23921150-9	2013	Pretreatment of cells with the ERK inhibitor PD98059, PI3K inhibitor LY294002, and GHSR-siRNA blocked the ghrelin-induced activation of ERK and AKT, respectively; however, ghrelin did not stimulate the phosphorylation of p38 or JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	mitogen-activated protein kinase 1	Mus musculus	136-139
23921150-10	2013	PD90859, LY294002 and GHSR-siRNA attenuated the anti-apoptosis effect of ghrelin in MC3T3-E1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	ghrelin	Mus musculus	73-80
24143235-6	2013	Genetic or pharmacological attenuation of beta-catenin by SiRNA or WP modulators (XAV939 and sulindac sulfide) and pharmacological mimicking of PTEN following LY294002 treatment downregulated MMP7 levels as well as enzymatic function of the secreted MMP7 in MMP7 positive PTEN-null TNBC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	matrix metallopeptidase 7	Homo sapiens	192-196
24143235-6	2013	Genetic or pharmacological attenuation of beta-catenin by SiRNA or WP modulators (XAV939 and sulindac sulfide) and pharmacological mimicking of PTEN following LY294002 treatment downregulated MMP7 levels as well as enzymatic function of the secreted MMP7 in MMP7 positive PTEN-null TNBC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	matrix metallopeptidase 7	Homo sapiens	250-254
24143235-6	2013	Genetic or pharmacological attenuation of beta-catenin by SiRNA or WP modulators (XAV939 and sulindac sulfide) and pharmacological mimicking of PTEN following LY294002 treatment downregulated MMP7 levels as well as enzymatic function of the secreted MMP7 in MMP7 positive PTEN-null TNBC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	matrix metallopeptidase 7	Homo sapiens	250-254
24143235-6	2013	Genetic or pharmacological attenuation of beta-catenin by SiRNA or WP modulators (XAV939 and sulindac sulfide) and pharmacological mimicking of PTEN following LY294002 treatment downregulated MMP7 levels as well as enzymatic function of the secreted MMP7 in MMP7 positive PTEN-null TNBC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	phosphatase and tensin homolog	Homo sapiens	272-276
24129178-6	2013	Using inhibitors against PI3K/Akt (LY294002) or MEK/ERK-specific (PD98059), the hypopigmentation effect was suppressed, and the gallic acid-initiated activation of MEK/ERK and PI3K/Akt was also revoked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	thymoma viral proto-oncogene 1	Mus musculus	30-33
23680593-6	2013	Furthermore, these cardioprotective effects in the hSCF/tTA mice were abrogated by doxycycline, which turned off hSCF overexpression, and by a PI3 kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	KIT ligand	Homo sapiens	51-55
24005670-6	2013	Of clinical significance, systemic administration of the AKT inhibitor LY294002 blocked the formation of tumor tissues in the bone marrow cavity and essentially abolished the MM-induced osteoclast formation and osteolysis in SCID mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	thymoma viral proto-oncogene 1	Mus musculus	57-60
24103747-6	2013	The combination of 1 muM ACR and 5 muM LY294002, in which the concentrations used are less than the IC50 values of these agents, synergistically inhibited the growth of HLF, Hep3B, and Huh7 human HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	MIR7-3 host gene	Homo sapiens	185-189
24103747-8	2013	The phosphorylation of RXRalpha, Akt, and ERK proteins in HLF cells were markedly inhibited by treatment with ACR plus LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	retinoid X receptor alpha	Homo sapiens	23-31
24103747-8	2013	The phosphorylation of RXRalpha, Akt, and ERK proteins in HLF cells were markedly inhibited by treatment with ACR plus LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Homo sapiens	33-36
24103747-10	2013	CONCLUSION: ACR and LY294002 cooperatively increase the expression of RARbeta, while inhibiting the phosphorylation of RXRalpha, and that these effects are associated with the induction of apoptosis and the inhibition of cell growth in human HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	retinoic acid receptor beta	Homo sapiens	70-77
24103747-10	2013	CONCLUSION: ACR and LY294002 cooperatively increase the expression of RARbeta, while inhibiting the phosphorylation of RXRalpha, and that these effects are associated with the induction of apoptosis and the inhibition of cell growth in human HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	retinoid X receptor alpha	Homo sapiens	119-127
23931732-1	2013	LY294002 is a synthetic quercetin-like compound, which, unlike wortmannin, is more specific inhibitor of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	vacuolar protein sorting 34	Arabidopsis thaliana	105-134
23931732-6	2013	Among proteins involved in vesicular trafficking, a small GTPase ARFA1f was more abundant, indicating its possible contribution to the aggregation and fusion of late endosomes triggered by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	ADP-ribosylation factor A1F	Arabidopsis thaliana	65-71
24098402-7	2013	Furthermore, we confirmed that miR-21 plays a protective role in myocardial apoptosis through PTEN/Akt signaling pathway, which was abrogated by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	microRNA 21a	Mus musculus	31-37
24098402-7	2013	Furthermore, we confirmed that miR-21 plays a protective role in myocardial apoptosis through PTEN/Akt signaling pathway, which was abrogated by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	phosphatase and tensin homolog	Mus musculus	94-98
24098402-7	2013	Furthermore, we confirmed that miR-21 plays a protective role in myocardial apoptosis through PTEN/Akt signaling pathway, which was abrogated by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	thymoma viral proto-oncogene 1	Mus musculus	99-102
23738793-9	2013	VEGF expression was increasing by protocatechuic acid and counteracted by VEGF antagonist sFlt-1, LY294002 and L-NAME in HBMEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	vascular endothelial growth factor A	Homo sapiens	0-4
23742826-7	2013	The use of the phosphatidylinositol 3 kinase (PI3K) inhibitor, Ly294002, and/or of siRNA to reduce the expression of the serine/threonine kinase Akt showed that these effects are mediated by the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	AKT serine/threonine kinase 1	Homo sapiens	145-148
23889671-9	2013	Likewise, administration of Akt and ERK1/2 signalling inhibitors, LY294002 and PD98059, attenuated the reduction in BP evoked by simvastatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
23889671-9	2013	Likewise, administration of Akt and ERK1/2 signalling inhibitors, LY294002 and PD98059, attenuated the reduction in BP evoked by simvastatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	mitogen activated protein kinase 3	Rattus norvegicus	36-42
23932581-5	2013	Inhibition of the PI3K/Akt pathway by a specific inhibitor of PI3K, LY294002, resulted in the restoration of the normal acinar phenotype.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Bos taurus	23-26
23911800-6	2013	Furthermore, a specific AKT inhibitor, LY294002, could enhance the anti-metastasis effects of NC, which indicated that NC suppressed metastasis of renal cancer cells partly via inhibition of AKT activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	24-27
23911800-6	2013	Furthermore, a specific AKT inhibitor, LY294002, could enhance the anti-metastasis effects of NC, which indicated that NC suppressed metastasis of renal cancer cells partly via inhibition of AKT activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	191-194
23900601-0	2013	A novel HDAC inhibitor OBP-801 and a PI3K inhibitor LY294002 synergistically induce apoptosis via the suppression of survivin and XIAP in renal cell carcinoma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	X-linked inhibitor of apoptosis	Homo sapiens	130-134
23900601-4	2013	We report that the combination of the novel histone deacetylase (HDAC) inhibitor OBP-801, also known as YM753 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 synergistically inhibits cell growth and induces apoptosis in RCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	118-147
23900601-5	2013	This combination activated caspase-3, -8 and -9 and the pan-caspase inhibitor zVAD-fmk significantly reduced the apoptotic response to the treatment with OBP-801 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	caspase 3	Homo sapiens	27-47
23900601-6	2013	Moreover, the combined treatment induced intracellular reactive oxygen species (ROS) and the radical scavenger N-acetyl-L-cysteine (NAC) blocked the intracellular ROS and apoptosis induced by OBP-801 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	204-212	X-linked Kx blood group	Homo sapiens	132-135
23900601-6	2013	Moreover, the combined treatment induced intracellular reactive oxygen species (ROS) and the radical scavenger N-acetyl-L-cysteine (NAC) blocked the intracellular ROS and apoptosis induced by OBP-801 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	204-212	odorant binding protein 2A	Homo sapiens	192-195
23900601-7	2013	The co-treatment with OBP-801 and LY294002 markedly decreased survivin and the X-linked inhibitor of apoptosis protein (XIAP) protein levels, but Bcl-2 family members were not altered by the OBP-801/LY294002 co-treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	X-linked inhibitor of apoptosis	Homo sapiens	79-118
23900601-7	2013	The co-treatment with OBP-801 and LY294002 markedly decreased survivin and the X-linked inhibitor of apoptosis protein (XIAP) protein levels, but Bcl-2 family members were not altered by the OBP-801/LY294002 co-treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	X-linked inhibitor of apoptosis	Homo sapiens	120-124
23900601-7	2013	The co-treatment with OBP-801 and LY294002 markedly decreased survivin and the X-linked inhibitor of apoptosis protein (XIAP) protein levels, but Bcl-2 family members were not altered by the OBP-801/LY294002 co-treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-207	odorant binding protein 2A	Homo sapiens	22-25
23900601-10	2013	Additionally, OBP-801 was significantly more effective than SAHA, another HDAC inhibitor, in the combination with LY294002 against 786-O cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	odorant binding protein 2A	Homo sapiens	14-17
23266287-8	2013	The inhibition of GSK-3beta phosphorylation and mTOR was achieved with LY294002 and rapamycin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	glycogen synthase kinase 3 beta	Homo sapiens	18-27
23266287-8	2013	The inhibition of GSK-3beta phosphorylation and mTOR was achieved with LY294002 and rapamycin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	mechanistic target of rapamycin kinase	Homo sapiens	48-52
23997215-9	2013	Inhibitors against PI3K (LY294002) and MEK1/2 (UO126) efficiently blocked IL-33-induced proliferation in all model systems used.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	interleukin 33	Homo sapiens	74-79
23640537-6	2013	This effect was blocked by phosphoinositide 3-kinase (PI3K) inhibitor LY294002 and Akt inhibitor triciribine, thus indicating the neuroprotective effects of MLB are most likely mediated by the PI3K/Akt/GSK-3beta pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	thymoma viral proto-oncogene 1	Mus musculus	198-201
23640537-6	2013	This effect was blocked by phosphoinositide 3-kinase (PI3K) inhibitor LY294002 and Akt inhibitor triciribine, thus indicating the neuroprotective effects of MLB are most likely mediated by the PI3K/Akt/GSK-3beta pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	glycogen synthase kinase 3 beta	Mus musculus	202-211
23695964-6	2013	The two isomers also enhanced phosphorylation of AKT and its downstream element glycogen synthase kinase-3beta, and this effect was abrogated by the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	AKT serine/threonine kinase 1	Rattus norvegicus	49-52
23695964-6	2013	The two isomers also enhanced phosphorylation of AKT and its downstream element glycogen synthase kinase-3beta, and this effect was abrogated by the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	glycogen synthase kinase 3 beta	Rattus norvegicus	80-110
23695964-6	2013	The two isomers also enhanced phosphorylation of AKT and its downstream element glycogen synthase kinase-3beta, and this effect was abrogated by the AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	AKT serine/threonine kinase 1	Rattus norvegicus	149-152
23859404-4	2013	LY294002 was seen to abolish phosphorylation of both ERK1/2 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 3	Mus musculus	53-59
23859404-4	2013	LY294002 was seen to abolish phosphorylation of both ERK1/2 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	64-67
23173828-8	2013	The addition of PD98059, LY294002, NAC, curcumin, EGCG, and SB203580 markedly inhibited TGM-2 expression induced by CsA (P &lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	transglutaminase 2	Homo sapiens	88-93
23173828-10	2013	In addition, TGM-2 induced by CsA is downregulated by PD98059, LY294002, NAC, curcumin, EGCG, and SB203580.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	transglutaminase 2	Homo sapiens	13-18
23814023-6	2013	Moreover, LY294002 suppressed the activity of the PI3K/AKT/mTOR axis and mitigated the p-Ser473-AKT activation feedback loop in both cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	55-58
23814023-6	2013	Moreover, LY294002 suppressed the activity of the PI3K/AKT/mTOR axis and mitigated the p-Ser473-AKT activation feedback loop in both cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	mechanistic target of rapamycin kinase	Homo sapiens	59-63
23814023-6	2013	Moreover, LY294002 suppressed the activity of the PI3K/AKT/mTOR axis and mitigated the p-Ser473-AKT activation feedback loop in both cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	96-99
23928058-12	2013	Inhibition of the PI3K/Akt/mTOR pathway by LY294002 induced nSR100 expression, whereas the specific MEK/ERK inhibitor U0126 inhibited nSR100 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	23-26
23928058-12	2013	Inhibition of the PI3K/Akt/mTOR pathway by LY294002 induced nSR100 expression, whereas the specific MEK/ERK inhibitor U0126 inhibited nSR100 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	mechanistic target of rapamycin kinase	Homo sapiens	27-31
23928058-12	2013	Inhibition of the PI3K/Akt/mTOR pathway by LY294002 induced nSR100 expression, whereas the specific MEK/ERK inhibitor U0126 inhibited nSR100 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	serine/arginine repetitive matrix 4	Homo sapiens	60-66
23916685-7	2013	Treatment with PI3K inhibitor LY294002 attenuated the pressure or inflammatory cytokine induction increases of cadherin-11, VEGF-D, and FGF-2 both in mRNA and protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	cadherin 11	Rattus norvegicus	111-122
23916685-7	2013	Treatment with PI3K inhibitor LY294002 attenuated the pressure or inflammatory cytokine induction increases of cadherin-11, VEGF-D, and FGF-2 both in mRNA and protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	vascular endothelial growth factor D	Rattus norvegicus	124-130
23916685-7	2013	Treatment with PI3K inhibitor LY294002 attenuated the pressure or inflammatory cytokine induction increases of cadherin-11, VEGF-D, and FGF-2 both in mRNA and protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	fibroblast growth factor 2	Rattus norvegicus	136-141
23172826-7	2013	GW5074, a Raf inhibitor, and LY294002, a PI3K inhibitor, inhibited MMP-2 and -9 activities and invasion in CT-26 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	matrix metallopeptidase 2	Mus musculus	67-79
23453443-8	2013	Inhibition of PI3K/Akt signaling by LY294002 (PI3K inhibitor) or PI3K-specific siRNA not only decreased the level of DATS-induced Nrf2-mediated HO-1 expression, but also diminished the protective effects of DATS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
23672191-6	2013	The inhibition of Akt, using LY294002, abolished the accumulation and nuclear translocation of beta-catenin induced by AIMP1, leading to a decrease in c-myc and cyclin D1 expression, which decreased the proliferation of BMMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	18-21
23672191-6	2013	The inhibition of Akt, using LY294002, abolished the accumulation and nuclear translocation of beta-catenin induced by AIMP1, leading to a decrease in c-myc and cyclin D1 expression, which decreased the proliferation of BMMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	catenin beta 1	Homo sapiens	95-107
23672191-6	2013	The inhibition of Akt, using LY294002, abolished the accumulation and nuclear translocation of beta-catenin induced by AIMP1, leading to a decrease in c-myc and cyclin D1 expression, which decreased the proliferation of BMMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	119-124
23672191-6	2013	The inhibition of Akt, using LY294002, abolished the accumulation and nuclear translocation of beta-catenin induced by AIMP1, leading to a decrease in c-myc and cyclin D1 expression, which decreased the proliferation of BMMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	151-156
23672191-6	2013	The inhibition of Akt, using LY294002, abolished the accumulation and nuclear translocation of beta-catenin induced by AIMP1, leading to a decrease in c-myc and cyclin D1 expression, which decreased the proliferation of BMMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	cyclin D1	Homo sapiens	161-170
24377895-12	2013	Further more, the expression of p-Akt and Bcl-2 were significantly decreased and the activity of caspase-3 was increased in both serum deprivation+SDF-1alpha+AMD3100 group and serum deprivation+SDF-1alpha+LY294002 group compared to serum deprivation+SDF-1alpha group (P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	caspase 3	Mus musculus	97-106
23617625-9	2013	Following AKT2 knockdown and treatment with the PI3K/AKT pathway inhibitor LY294002, the expression of OCN in MC3T3-E1 cells was decreased (p&lt;0.05), as was the calcification area (p&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	thymoma viral proto-oncogene 2	Mus musculus	10-14
23617625-9	2013	Following AKT2 knockdown and treatment with the PI3K/AKT pathway inhibitor LY294002, the expression of OCN in MC3T3-E1 cells was decreased (p&lt;0.05), as was the calcification area (p&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	thymoma viral proto-oncogene 1	Mus musculus	10-13
23617625-9	2013	Following AKT2 knockdown and treatment with the PI3K/AKT pathway inhibitor LY294002, the expression of OCN in MC3T3-E1 cells was decreased (p&lt;0.05), as was the calcification area (p&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	bone gamma-carboxyglutamate protein 2	Mus musculus	103-106
24156430-0	2013	[Antiproliferative effects of LY294002 on MCL Jeko-1 cell line and its mechanism].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	C-type lectin domain family 4 member D	Homo sapiens	42-45
24156430-1	2013	This study was aimed to investigate the effects of LY294002, a specific inhibitor of phosphatidylinositol 3-kinase, on growth and apoptosis of MCL Jeko-1 cell line and its mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	C-type lectin domain family 4 member D	Homo sapiens	143-146
23453443-8	2013	Inhibition of PI3K/Akt signaling by LY294002 (PI3K inhibitor) or PI3K-specific siRNA not only decreased the level of DATS-induced Nrf2-mediated HO-1 expression, but also diminished the protective effects of DATS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	130-134
23843241-7	2013	This inhibitory action of GDF9 was prevented by the addition of a phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	growth differentiation factor 9	Mus musculus	26-30
24156430-5	2013	Phosphorylation levels of PI3K/Akt signaling pathway protein p-Akt, p-mTOR, p-P70S6K decreased, the expression of apoptosis-related protein cyclin D1, Bcl-2, procaspase-3 was down-regulated.It is concluded that the LY294002 can inhibit Jeko-1 cell proliferation, which may be realized through down-regulating the phosphorylation level of p-Akt, p-mTOR, p-P70S6K, inhibiting the P13k/Akt signaling pathway, and promoting the cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	AKT serine/threonine kinase 1	Homo sapiens	31-34
23973711-10	2013	The Akt inhibitor, LY294002, augmented the effect of simvastatin on PTEN wild-type TNBC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	4-7
23973711-10	2013	The Akt inhibitor, LY294002, augmented the effect of simvastatin on PTEN wild-type TNBC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	phosphatase and tensin homolog	Homo sapiens	68-72
23912452-7	2013	Moreover, p-AKT expression was increased in miR-17-knockdown cells that led to enhanced cell invasion, which was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	microRNA 17	Homo sapiens	44-50
24040255-6	2013	The specific inhibitor of phosphatidylinositol 3-kinase (PI3K), LY294002, significantly down-regulated ephrin-A1-induced expression of phosphorylated Akt(Ser473) as well as phosphorylation of eNOS(Ser1177).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	ephrin A1	Homo sapiens	103-112
24069351-6	2013	Blocking these pathways by specific inhibitor LY294002 or U0126 abrogated HMW-HA-regulated DSc proliferation and apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	desmocollin 3	Homo sapiens	91-94
24040255-6	2013	The specific inhibitor of phosphatidylinositol 3-kinase (PI3K), LY294002, significantly down-regulated ephrin-A1-induced expression of phosphorylated Akt(Ser473) as well as phosphorylation of eNOS(Ser1177).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Homo sapiens	150-153
23045284-11	2013	However, it resulted from the activation of a phosphatidylinositol 3-kinases-like mitogen-activated protein kinase pathway, as assessed by the fact that LY294002 and U0126 restored high Cdx2 expression in hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	caudal type homeobox 2	Homo sapiens	186-190
23774231-9	2013	These effects were abrogated when cells were pretreated with the Akt inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	65-68
24049436-9	2013	Interestingly, pretreatment of RGCs with AG1024 (an IGF-1 inhibitor), U0126 (an Erk-1/2 inhibitor), and LY294002 (an Akt inhibitor) markedly attenuated the effects of IGF-1 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	AKT serine/threonine kinase 1	Rattus norvegicus	117-120
24049436-9	2013	Interestingly, pretreatment of RGCs with AG1024 (an IGF-1 inhibitor), U0126 (an Erk-1/2 inhibitor), and LY294002 (an Akt inhibitor) markedly attenuated the effects of IGF-1 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	insulin-like growth factor 1	Rattus norvegicus	167-172
24023933-5	2013	By the inhibition of LY294002 and PD184352, we confirm that hydronephrotic urine promotes urothelial carcinoma cell (T24) and immortalized normal urothelial cells (E6) proliferation, migration and invasion in a dose-dependent manner through the activation of the mTORC2-AKT and ERK signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	CREB regulated transcription coactivator 2	Mus musculus	263-269
24023933-5	2013	By the inhibition of LY294002 and PD184352, we confirm that hydronephrotic urine promotes urothelial carcinoma cell (T24) and immortalized normal urothelial cells (E6) proliferation, migration and invasion in a dose-dependent manner through the activation of the mTORC2-AKT and ERK signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Rattus norvegicus	270-273
23625292-6	2013	Actinomycin D (1 mg/ml), losartan (50 muM), and phosphatidylinositol-3 kinase inhibitor LY294002 (50 muM) abolished the promoting effect of Ang-II on ET-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	latexin	Homo sapiens	101-104
23744557-8	2013	P-gp expression was augmented in response to activation of the PI3K/Akt pathway, which could be modified by PI3K inhibitor LY294002 or multidrug resistance siRNA transfection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
23744557-8	2013	P-gp expression was augmented in response to activation of the PI3K/Akt pathway, which could be modified by PI3K inhibitor LY294002 or multidrug resistance siRNA transfection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	AKT serine/threonine kinase 1	Homo sapiens	68-71
23707520-8	2013	Furthermore, Akt inhibition by LY294002 or ERK1/2 inhibition by PD98059 induced tube breakdown and cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	13-16
23720233-7	2013	Elevated vegfaa expression in mutant embryos lacking functional Pten was suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	vascular endothelial growth factor Aa	Danio rerio	9-15
23720233-9	2013	Combined treatment with suboptimal concentrations of sunitinib and LY294002 rescued enhanced angiogenesis in pten mutant embryos without the dramatic increase in vegfaa expression, suggesting a new approach for therapeutic intervention in VEGFR-signaling-dependent tumors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	phosphatase and tensin homolog B	Danio rerio	109-113
23625292-6	2013	Actinomycin D (1 mg/ml), losartan (50 muM), and phosphatidylinositol-3 kinase inhibitor LY294002 (50 muM) abolished the promoting effect of Ang-II on ET-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	endothelin 1	Homo sapiens	150-154
23986222-10	2013	LY294002, not SB431542 attenuated the promotional effect of rapamycin on CTGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cellular communication network factor 2	Homo sapiens	73-77
23720233-7	2013	Elevated vegfaa expression in mutant embryos lacking functional Pten was suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	phosphatase and tensin homolog B	Danio rerio	64-68
23793038-3	2013	However, after 24 h co-exposure to DEHP at indicated concentrations plus 50.0 muM LY294002 (PI3K inhibitor), cell viability was significantly decreased compared to the corresponding DEHP treated groups.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	latexin	Homo sapiens	78-81
23793038-6	2013	The findings showed that LY294002 attenuated DEHP-induced up-regulation of the selected genes (pi3k, akt, mtor and p70s6k) involved in PI3K-AKT-mTOR signaling pathway at both mRNA and protein levels thus inhibited the cell abnormal proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	101-104
23793038-6	2013	The findings showed that LY294002 attenuated DEHP-induced up-regulation of the selected genes (pi3k, akt, mtor and p70s6k) involved in PI3K-AKT-mTOR signaling pathway at both mRNA and protein levels thus inhibited the cell abnormal proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	mechanistic target of rapamycin kinase	Homo sapiens	106-110
23793038-6	2013	The findings showed that LY294002 attenuated DEHP-induced up-regulation of the selected genes (pi3k, akt, mtor and p70s6k) involved in PI3K-AKT-mTOR signaling pathway at both mRNA and protein levels thus inhibited the cell abnormal proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	ribosomal protein S6 kinase B1	Homo sapiens	115-121
23793038-6	2013	The findings showed that LY294002 attenuated DEHP-induced up-regulation of the selected genes (pi3k, akt, mtor and p70s6k) involved in PI3K-AKT-mTOR signaling pathway at both mRNA and protein levels thus inhibited the cell abnormal proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	140-143
23793038-6	2013	The findings showed that LY294002 attenuated DEHP-induced up-regulation of the selected genes (pi3k, akt, mtor and p70s6k) involved in PI3K-AKT-mTOR signaling pathway at both mRNA and protein levels thus inhibited the cell abnormal proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	mechanistic target of rapamycin kinase	Homo sapiens	144-148
23820591-6	2013	The recombinant RTB-induced production of NO, TNF-alpha and IL-6 was inhibited in the macrophages treated with the pharmacological inhibitors genistein, LY294002, staurosporine, AG490, SB203580 and BAY 11-7082, indicating the possible involvement of protein tyrosine kinases, PI3K, PKC, JAK2, p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB in the above processes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	tumor necrosis factor	Mus musculus	46-55
22965839-7	2013	The addition of NAC, LY294002, herbimycin A, NS398, and PD98059 markedly inhibited the arecoline-induced PAR-1 expression (p &lt; .05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	coagulation factor II thrombin receptor	Homo sapiens	105-110
22965839-9	2013	Arecoline-induced PAR-1 expression was downregulated by NAC, LY294002, herbimycin A, NS398, and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	coagulation factor II thrombin receptor	Homo sapiens	18-23
23686005-10	2013	LY294002, a specific Akt inhibitor, attenuated LPS-induced pro-inflammatory gene expression via suppression of NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	21-24
23820591-6	2013	The recombinant RTB-induced production of NO, TNF-alpha and IL-6 was inhibited in the macrophages treated with the pharmacological inhibitors genistein, LY294002, staurosporine, AG490, SB203580 and BAY 11-7082, indicating the possible involvement of protein tyrosine kinases, PI3K, PKC, JAK2, p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB in the above processes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	interleukin 6	Mus musculus	60-64
23307774-7	2013	Pretreatment with the PI3K inhibitor LY294002 inhibited adiponectin secretion and mRNA levels, and significantly potentiated the inhibitory effect of LA on adiponectin secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	adiponectin, C1Q and collagen domain containing	Homo sapiens	56-67
23460471-5	2013	Snail expression induced by PDGF-BB in MSCs is inhibited by LY294002 and PD98059, which are inhibitors of the PI3K/AKT and MAPK1/2/ERK1/2 signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Rattus norvegicus	115-118
23460471-5	2013	Snail expression induced by PDGF-BB in MSCs is inhibited by LY294002 and PD98059, which are inhibitors of the PI3K/AKT and MAPK1/2/ERK1/2 signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	mitogen-activated protein kinase 12	Rattus norvegicus	123-130
23460471-5	2013	Snail expression induced by PDGF-BB in MSCs is inhibited by LY294002 and PD98059, which are inhibitors of the PI3K/AKT and MAPK1/2/ERK1/2 signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	mitogen activated protein kinase 3	Rattus norvegicus	131-137
23682582-9	2013	Interestingly, pretreatment of mitogen-activated protein kinase kinases/extracellular signal-regulated kinase (MEK/ERK) signaling inhibitor U0126 had a similar effect as that of sorafenib pretreatment in hepatocellular carcinoma cells, whereas pretreatment of phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling inhibitor LY294002 in the same cells had no effect on radiosensitization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	334-342	mitogen-activated protein kinase kinase 7	Homo sapiens	111-114
23307774-7	2013	Pretreatment with the PI3K inhibitor LY294002 inhibited adiponectin secretion and mRNA levels, and significantly potentiated the inhibitory effect of LA on adiponectin secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	adiponectin, C1Q and collagen domain containing	Homo sapiens	156-167
23679681-9	2013	Inhibition of COX-2 activity with the selective inhibitor, NS398, and inhibition of AKT activation using the PI3K inhibitor, LY294002, in tumor cells confirmed that melatonin-induced apoptosis was COX-2/PI3K/AKT-dependent, suggesting that the COX-2/PI3K/AKT pathway plays a role in melatonin inhibition of IAPs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	AKT serine/threonine kinase 1	Homo sapiens	84-87
23611177-7	2013	Activation of GSK3beta by LY294002 completely blocked the antidepressant-like effects of 7-CTKA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	glycogen synthase kinase 3 beta	Rattus norvegicus	14-22
23836295-10	2013	Furthermore, the anti-apoptotic function of FAM9C could be prevented when the PI3K-Akt pathway was in a loss-of-function caused by RNA interference against Akt or PI3K inhibitor LY294002 in HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	family with sequence similarity 9 member C	Homo sapiens	44-49
23711089-9	2013	Furthermore, consistent with inhibition of AKT activation by using the PI3K inhibitor LY294002, melatonin elevated the levels of CHOP (C/EBP-homologous protein) and reduced the levels of Survivin (a member of the inhibitor of apoptosis protein family)suggesting that inhibition of the PI3K/AKT pathway by melatonin-reversed ER stress-induced resistance to doxorubicin in human hepatocellular carcinoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	AKT serine/threonine kinase 1	Homo sapiens	43-46
23749166-10	2013	MEK inhibitor (PD98059) and PI3K inhibitor (LY294002) decreased ERK and Akt activity, respectively, and reduced VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	vascular endothelial growth factor A	Macaca mulatta	112-116
23836295-10	2013	Furthermore, the anti-apoptotic function of FAM9C could be prevented when the PI3K-Akt pathway was in a loss-of-function caused by RNA interference against Akt or PI3K inhibitor LY294002 in HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	AKT serine/threonine kinase 1	Homo sapiens	83-86
23850990-9	2013	NO production following incubation with PLC was abolished in endothelial cells coincubated with L-NAME, PD173955, LY294002, MK-2206 and compound C. In conclusion, PLC, via AMPK/Src-mediated signaling that leads to activation of PI3 kinase and Akt, stimulates eNOS, leading to increased production of NO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	177-180
23765731-10	2013	Consistently the PI3K/AKT inhibitor LY294002 mimicked the effects of DKK3 knockdown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	22-25
23765731-10	2013	Consistently the PI3K/AKT inhibitor LY294002 mimicked the effects of DKK3 knockdown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	69-73
23707761-9	2013	LY294002, an inhibitor of PI3K/Akt signaling, significantly decreased Akt phosphorylation in the hippocampus of DA/UA mice, which weakened UA actions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	31-34
23707761-9	2013	LY294002, an inhibitor of PI3K/Akt signaling, significantly decreased Akt phosphorylation in the hippocampus of DA/UA mice, which weakened UA actions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	70-73
23977357-4	2013	In this report, we detected a marked increase in HEXIM1 protein levels in the differentiated human pluripotent stem cells (hPSCs) induced by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	HEXIM P-TEFb complex subunit 1	Homo sapiens	49-55
23990921-4	2013	We show that SopB-mediated Akt activation is only partially sensitive to PI3-kinase inhibitors LY294002 and wortmannin in HeLa cells, suggesting that Class I PI3-kinases play only a minor role in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	27-30
23975168-6	2013	The Akt activation appeared to require the PI3K pathway as its activation was abolished by the PI3K inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Homo sapiens	4-7
23648570-9	2013	LY294002, an inhibitor of phosphatidylinositol-3-kinase, prevented the regulatory effect of insulin on the expression levels of miR-124 and Dlx5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	distal-less homeobox 5	Mus musculus	140-144
23843462-6	2013	The AKT phosphorylation/activation was mediated mainly through the PI3K pathway because it was blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	AKT serine/threonine kinase 1	Homo sapiens	4-7
23603434-3	2013	This study revealed that over-expression of ABCG2 in Jurkat and HL60 cells led to an increased SP fraction, up-regulated levels of phosphorylated-PI3K and phosphorylated-Akt, and enhanced drug resistance, all of which could be attenuated by treatment with either the PI3K inhibitor LY294002 or the mTOR inhibitor rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	282-290	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	44-49
23937725-12	2013	The HRG-beta1-induced expressions of Snail, vimentin, and fibronectin, and nuclear colocalization of phospho-Smad2 and Snail were inhibited by pretreatment with a PI3k inhibitor, LY294002, or two phospho-Smad2 inhibitors, PD169316 or SB203580 and cancer cell migration by HRG-beta1 was inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	8-13
23937725-12	2013	The HRG-beta1-induced expressions of Snail, vimentin, and fibronectin, and nuclear colocalization of phospho-Smad2 and Snail were inhibited by pretreatment with a PI3k inhibitor, LY294002, or two phospho-Smad2 inhibitors, PD169316 or SB203580 and cancer cell migration by HRG-beta1 was inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	fibronectin 1	Homo sapiens	58-69
23937725-12	2013	The HRG-beta1-induced expressions of Snail, vimentin, and fibronectin, and nuclear colocalization of phospho-Smad2 and Snail were inhibited by pretreatment with a PI3k inhibitor, LY294002, or two phospho-Smad2 inhibitors, PD169316 or SB203580 and cancer cell migration by HRG-beta1 was inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	snail family transcriptional repressor 1	Homo sapiens	119-124
23937725-12	2013	The HRG-beta1-induced expressions of Snail, vimentin, and fibronectin, and nuclear colocalization of phospho-Smad2 and Snail were inhibited by pretreatment with a PI3k inhibitor, LY294002, or two phospho-Smad2 inhibitors, PD169316 or SB203580 and cancer cell migration by HRG-beta1 was inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	SMAD family member 2	Homo sapiens	204-209
23937725-12	2013	The HRG-beta1-induced expressions of Snail, vimentin, and fibronectin, and nuclear colocalization of phospho-Smad2 and Snail were inhibited by pretreatment with a PI3k inhibitor, LY294002, or two phospho-Smad2 inhibitors, PD169316 or SB203580 and cancer cell migration by HRG-beta1 was inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	276-281
23711961-9	2013	And PI3K inhibitor, LY294002, effectively prevented LPA-induced miR-23a expression in cardiomyocytes, suggesting that LPA might induce miR-23a elevation by activating LPA3 and PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	microRNA 23a	Rattus norvegicus	64-71
22964642-9	2013	Pre-treatment of Keap1(-/-) MEFs or A549 cells with the LY294002 PI3K inhibitor or the MK-2206 PKB/Akt inhibitor increased their sensitivity to acrolein, chlorambucil and cisplatin between 1.9-fold and 3.1-fold, and this was substantially attenuated by simultaneous pre-treatment with the GSK-3 inhibitor CT99021.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	kelch-like ECH-associated protein 1	Mus musculus	17-22
23951091-9	2013	Addition of the PI3K-inhibitor LY294002 and the MEK-inhibitor U0126 to the HMEC-1 inhibited this effect, suggesting that both Akt and ERK pathways are involved in hDPSC-mediated HMEC-1 migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	126-129
23951091-9	2013	Addition of the PI3K-inhibitor LY294002 and the MEK-inhibitor U0126 to the HMEC-1 inhibited this effect, suggesting that both Akt and ERK pathways are involved in hDPSC-mediated HMEC-1 migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	mitogen-activated protein kinase 1	Homo sapiens	134-137
23698119-6	2013	Those responses were inhibited by gap junction blockade with 18 beta-glycyrrhetinic acid (100 muM) or phosphoinositide 3 kinase inhibition with 2-morpholin-4-yl-8-phenylchromen-4-one (50 muM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-182	latexin	Homo sapiens	187-190
23951036-10	2013	Inhibition of Akt activation by treating with phosphoinositide 3-kinase (PI3K) inhibitor LY294002 decreased IR cell invasion, whereas inhibition of Erk1/2 activation by mitogen-activated protein kinase kinase (MEK) inhibitor U0126 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	AKT serine/threonine kinase 1	Homo sapiens	14-17
23924390-8	2013	In addition, treatment of cells with LY294002, an inhibitor of PI 3-kinase, or mutation of the PX domain reduces tyrosine phosphorylation and membrane translocation of Tks5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	SH3 and PX domains 2A	Homo sapiens	168-172
23831464-7	2013	Treatment with cholesterol, LY294002, Akt inhibitor IV, U0126, and SP6001250 resulted in abrogation or significant attenuation of nystatin-induced CCL2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	C-C motif chemokine ligand 2	Homo sapiens	147-151
23765166-8	2013	The luciferase reporter gene assay showed that the activity of the MRP1 promoter was markedly increased by VEGF stimulation, while LY294002, an inhibitor of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway, reduced this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	161-190
23765166-8	2013	The luciferase reporter gene assay showed that the activity of the MRP1 promoter was markedly increased by VEGF stimulation, while LY294002, an inhibitor of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway, reduced this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	216-219
23668972-6	2013	We treated Hela cells with GA to observe Akt degradation and found that LY294002 delayed Akt degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	89-92
23562764-9	2013	Inhibition of phosphoinositide-dependent kinase-1 (PDK1) by Ly294002 or knockdown of PDK1 also led to downregulation of basal PKCeta but had no effect on PKC activator-induced upregulation of PKCeta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	pyruvate dehydrogenase kinase 1	Homo sapiens	14-49
23562764-9	2013	Inhibition of phosphoinositide-dependent kinase-1 (PDK1) by Ly294002 or knockdown of PDK1 also led to downregulation of basal PKCeta but had no effect on PKC activator-induced upregulation of PKCeta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	pyruvate dehydrogenase kinase 1	Homo sapiens	51-55
23562764-9	2013	Inhibition of phosphoinositide-dependent kinase-1 (PDK1) by Ly294002 or knockdown of PDK1 also led to downregulation of basal PKCeta but had no effect on PKC activator-induced upregulation of PKCeta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	protein kinase C epsilon	Homo sapiens	126-129
23859018-6	2013	Moreover, the activation of insulin signaling mediated by knockdown RBP4 in porcine preadipocytes was recovered in the suppression of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	insulin	Homo sapiens	28-35
23859018-6	2013	Moreover, the activation of insulin signaling mediated by knockdown RBP4 in porcine preadipocytes was recovered in the suppression of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	retinol binding protein 4	Homo sapiens	68-72
23711961-9	2013	And PI3K inhibitor, LY294002, effectively prevented LPA-induced miR-23a expression in cardiomyocytes, suggesting that LPA might induce miR-23a elevation by activating LPA3 and PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	microRNA 23a	Rattus norvegicus	135-142
23711961-9	2013	And PI3K inhibitor, LY294002, effectively prevented LPA-induced miR-23a expression in cardiomyocytes, suggesting that LPA might induce miR-23a elevation by activating LPA3 and PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	lysophosphatidic acid receptor 3	Rattus norvegicus	167-171
23711961-9	2013	And PI3K inhibitor, LY294002, effectively prevented LPA-induced miR-23a expression in cardiomyocytes, suggesting that LPA might induce miR-23a elevation by activating LPA3 and PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Rattus norvegicus	181-184
23702325-9	2013	VEGF expression was increasing by Cornin and counteracted by VEGF antagonist sFlt-1, LY294002 and L-NAME in HMBEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	vascular endothelial growth factor A	Homo sapiens	0-4
23707969-6	2013	Both the ALP activity and ALP and BMP-4 mRNA increments induced by ATP and UTP are inhibited by Ly294002, a PI3K inhibitor, suggesting the involvement of PI3K/AKT signaling pathway in purinergic modulation of osteoblast differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	bone morphogenetic protein 4	Rattus norvegicus	34-39
23707969-6	2013	Both the ALP activity and ALP and BMP-4 mRNA increments induced by ATP and UTP are inhibited by Ly294002, a PI3K inhibitor, suggesting the involvement of PI3K/AKT signaling pathway in purinergic modulation of osteoblast differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
23869765-8	2013	Finally, PI3K/AKT pathway inhibitor LY294002 reduced expressions of mesenchymal markers and stem-cell gene activity in spheroid cells, enhancing sensitivity of spheroid cells to paclitaxel treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	14-17
23702325-9	2013	VEGF expression was increasing by Cornin and counteracted by VEGF antagonist sFlt-1, LY294002 and L-NAME in HMBEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	vascular endothelial growth factor A	Homo sapiens	61-65
23702325-10	2013	Tube formation was increased by Cornin and counteracted by VEGF receptor blocker-SU1498, LY294002 and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	vascular endothelial growth factor A	Homo sapiens	59-63
23519142-5	2013	These effects were blocked by the phosphatidylinositol 3-kinase inhibitor LY294002, pointing to the involvement of the Akt pathway in mediating the process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Rattus norvegicus	119-122
23615713-9	2013	In addition, alphavbeta6 integrin induced the phosphorylation of p38 MAPK and PI3 K/Akt, contributing to the up-regulation of uPA, as treatment with the specific inhibitor for p38 mitogen-activated protein kinases (MAPK) (SB203580) or phosphatidylinositol 3-kinase (PI3 K)/Akt (LY294002) strikingly abrogated uPA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	278-286	plasminogen activator, urokinase	Homo sapiens	126-129
23625205-9	2013	Pretreatment with EGFR inhibitor AG1478 or phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 rescued ADAM17-mediated cisplatin resistance of HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	43-72
23625205-9	2013	Pretreatment with EGFR inhibitor AG1478 or phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 rescued ADAM17-mediated cisplatin resistance of HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	ADAM metallopeptidase domain 17	Homo sapiens	107-113
23743572-2	2013	LY294002 is a commonly used pharmacological inhibitor that acts at the ATP-binding site of the PI3K enzyme, selectively inhibiting the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	140-143
23538947-12	2013	By using a specific Phosphoinositide 3-kinase (PI3K) inhibitor (LY294002), we found that basal activity of PI3K was required for secretion but was independent of S1P/S1PR2 axis activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	20-45
23621784-6	2013	We next report that removal of LY294002 from LY294002-treated OK cells induced a spectacular burst of recycling tubules and restoration of megalin surface pool.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	low density lipoprotein receptor-related protein 2	Mus musculus	139-146
23621784-6	2013	We next report that removal of LY294002 from LY294002-treated OK cells induced a spectacular burst of recycling tubules and restoration of megalin surface pool.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	low density lipoprotein receptor-related protein 2	Mus musculus	139-146
24187831-5	2013	The expression of ERK1/2 and NSE was detected when the ERK1/2 and PI3K/AKT/ mTOR signal pathway was blocked by PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	mitogen-activated protein kinase 3	Mus musculus	18-24
23743572-8	2013	We found that gastric cancer cells treated with LY294002 showed a significant inhibition of PI3K/Akt activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	97-100
24187831-5	2013	The expression of ERK1/2 and NSE was detected when the ERK1/2 and PI3K/AKT/ mTOR signal pathway was blocked by PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	enolase 2, gamma neuronal	Mus musculus	29-32
23743572-11	2013	Finally, LY294002 was able to decrease the expression of MDR1/P-gp, Bcl-2 and XIAP, and upregulate expression of Bax and caspase-3, thereby enhancing chemosensitivity to VCR by inhibiting a drug pump and inducing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	ATP binding cassette subfamily B member 1	Homo sapiens	57-61
24187831-5	2013	The expression of ERK1/2 and NSE was detected when the ERK1/2 and PI3K/AKT/ mTOR signal pathway was blocked by PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	mitogen-activated protein kinase 3	Mus musculus	55-61
24187831-5	2013	The expression of ERK1/2 and NSE was detected when the ERK1/2 and PI3K/AKT/ mTOR signal pathway was blocked by PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	thymoma viral proto-oncogene 1	Mus musculus	71-74
24187831-5	2013	The expression of ERK1/2 and NSE was detected when the ERK1/2 and PI3K/AKT/ mTOR signal pathway was blocked by PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	mechanistic target of rapamycin kinase	Mus musculus	76-80
23743572-11	2013	Finally, LY294002 was able to decrease the expression of MDR1/P-gp, Bcl-2 and XIAP, and upregulate expression of Bax and caspase-3, thereby enhancing chemosensitivity to VCR by inhibiting a drug pump and inducing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	ATP binding cassette subfamily B member 1	Homo sapiens	62-66
23743572-11	2013	Finally, LY294002 was able to decrease the expression of MDR1/P-gp, Bcl-2 and XIAP, and upregulate expression of Bax and caspase-3, thereby enhancing chemosensitivity to VCR by inhibiting a drug pump and inducing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	BCL2 apoptosis regulator	Homo sapiens	68-73
23743572-11	2013	Finally, LY294002 was able to decrease the expression of MDR1/P-gp, Bcl-2 and XIAP, and upregulate expression of Bax and caspase-3, thereby enhancing chemosensitivity to VCR by inhibiting a drug pump and inducing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	X-linked inhibitor of apoptosis	Homo sapiens	78-82
23743572-11	2013	Finally, LY294002 was able to decrease the expression of MDR1/P-gp, Bcl-2 and XIAP, and upregulate expression of Bax and caspase-3, thereby enhancing chemosensitivity to VCR by inhibiting a drug pump and inducing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	BCL2 associated X, apoptosis regulator	Homo sapiens	113-116
23743572-11	2013	Finally, LY294002 was able to decrease the expression of MDR1/P-gp, Bcl-2 and XIAP, and upregulate expression of Bax and caspase-3, thereby enhancing chemosensitivity to VCR by inhibiting a drug pump and inducing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	caspase 3	Homo sapiens	121-130
23743572-12	2013	These results suggested that the PI3K/Akt inhibitor LY294002 can enhance chemosensitivity of human gastric cancer to VCR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	38-41
23922669-8	2013	Treatment with specific inhibitors LY294002 and U0126 reversed the CAFs-mediated cell proliferation (P&lt;0.0001), suggesting for a role of these pathways in modulating endometrial cancer cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	T-box transcription factor 1	Homo sapiens	67-71
23623869-6	2013	PI3K inhibitors, wortmannin and LY294002 blocked insulin, but not 17alpha, 20beta-DHP-induced GVBD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	preproinsulin	Danio rerio	49-56
23791833-9	2013	An AKT inhibitor LY294002 effectively suppressed IKK/IkappaB/NF-kappaB signaling and PON1 gene expression induced by IL-6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	AKT serine/threonine kinase 1	Homo sapiens	3-6
23791833-9	2013	An AKT inhibitor LY294002 effectively suppressed IKK/IkappaB/NF-kappaB signaling and PON1 gene expression induced by IL-6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	nuclear factor kappa B subunit 1	Homo sapiens	61-70
23791833-9	2013	An AKT inhibitor LY294002 effectively suppressed IKK/IkappaB/NF-kappaB signaling and PON1 gene expression induced by IL-6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	paraoxonase 1	Homo sapiens	85-89
23791833-9	2013	An AKT inhibitor LY294002 effectively suppressed IKK/IkappaB/NF-kappaB signaling and PON1 gene expression induced by IL-6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	interleukin 6	Homo sapiens	117-121
23500140-6	2013	High glucose also increased UCHL5 protein expression, which was attenuated by LY294002, the dominant-negative p85 and the dominant-negative CREB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	ubiquitin carboxyl-terminal esterase L5	Mus musculus	28-33
23567184-7	2013	SDF-1alpha inhibited the elevated FN mRNA expression induced by TGF-beta1 and high glucose through CXCR4 and PI3K/Akt signaling pathway, as the effect of SDF-1alpha was reversed by CXCR4 antagonist AMD3100 and PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	225-233	fibronectin 1	Rattus norvegicus	34-36
23567184-7	2013	SDF-1alpha inhibited the elevated FN mRNA expression induced by TGF-beta1 and high glucose through CXCR4 and PI3K/Akt signaling pathway, as the effect of SDF-1alpha was reversed by CXCR4 antagonist AMD3100 and PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	225-233	transforming growth factor, beta 1	Rattus norvegicus	64-73
23403077-8	2013	The growth of the tumor spheres could also be reduced by the CXCR2 specific inhibitor SB225002 or the PI3K/AKT inhibitor LY294002, indicating that the endogenously produced CXCL8 plays an autocrine role in the growth of the tumor spheres.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	AKT serine/threonine kinase 1	Homo sapiens	107-110
23567184-7	2013	SDF-1alpha inhibited the elevated FN mRNA expression induced by TGF-beta1 and high glucose through CXCR4 and PI3K/Akt signaling pathway, as the effect of SDF-1alpha was reversed by CXCR4 antagonist AMD3100 and PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	225-233	C-X-C motif chemokine receptor 4	Rattus norvegicus	181-186
23403077-8	2013	The growth of the tumor spheres could also be reduced by the CXCR2 specific inhibitor SB225002 or the PI3K/AKT inhibitor LY294002, indicating that the endogenously produced CXCL8 plays an autocrine role in the growth of the tumor spheres.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	173-178
23815774-12	2013	In addition, the MAPK-specific inhibitors, PD98059 and LY294002, blocked the Foxc2-induced regulation of BMSC differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	forkhead box C2	Rattus norvegicus	77-82
23935944-12	2013	However, the PI-3 kinase inhibitor LY294002, which abolished the effect of PUGNAc+glucosamine on Akt phosphorylation, did not impair the protective effects of PUGNAc+glucosamine against tamoxifen-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	97-100
23624822-7	2013	Importantly, the protective effect of CLCE on Dex-induced cytotoxicity in INS-1 cells was attenuated by LY294002, an inhibitor of PI3K/PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	insulin 1	Rattus norvegicus	74-79
23510069-5	2013	LY294002, an inhibitor of phosphatidylinositol 3-kinase, and rapamycin, an inhibitor of mTORC1, suppressed the ability of SOX2 to enhance proliferation of ESCC cells in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	SRY-box transcription factor 2	Homo sapiens	122-126
23510069-8	2013	LY294002 suppressed the ability of SOX2 to enhance tumor growth of ESCC by reducing cell proliferation, but not by enhancing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	SRY-box transcription factor 2	Homo sapiens	35-39
23376468-2	2013	PI3K/AKT signaling was manipulated using the activator (IGF-1) and the inhibitor (LY 294002) of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-91	AKT serine/threonine kinase 1	Homo sapiens	5-8
23376468-2	2013	PI3K/AKT signaling was manipulated using the activator (IGF-1) and the inhibitor (LY 294002) of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-91	AKT serine/threonine kinase 1	Homo sapiens	105-108
23615915-10	2013	Moreover, treatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 reduced the phosphorylation of FOXO1 and increased the cytotoxicity of docetaxel in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	forkhead box O1	Homo sapiens	116-121
23742697-8	2013	LY294002 (Akt/PI3-K inhibitor) or SB203580 (p38 MAPK inhibitor) abolished the effects of H2 S on eNOS phosphorylation, NO production, cell proliferation and tube formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	10-13
23255067-4	2013	This response was completely blocked when myoblasts were incubated with LY294002 or transfected with the dominant-negative p110 gamma, suggesting a fundamental role of phosphatidylinositol 3-kinase (PI3K) in PLCgamma activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	123-133
23742697-8	2013	LY294002 (Akt/PI3-K inhibitor) or SB203580 (p38 MAPK inhibitor) abolished the effects of H2 S on eNOS phosphorylation, NO production, cell proliferation and tube formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 3	Homo sapiens	97-101
23815230-4	2013	Using the scratch wound assay and a modified Boyden chamber, we found that LY294002, a selective phosphatidylinositol 3-kinase inhibitor, and LiCl, a selective GSK3beta inhibitor, abolished LGI3-induced cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	leucine rich repeat LGI family member 3	Homo sapiens	190-194
23266915-6	2013	Furthermore, 17beta-estradiol also prolonged the up-regulation of GSK-3beta pS9 for at least 8 h. However, this action of 17beta-estradiol was abrogated by PKA inhibitor H-89, AKT inhibitor LY294002, and MAPK inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	glycogen synthase kinase 3 beta	Rattus norvegicus	66-75
23266915-6	2013	Furthermore, 17beta-estradiol also prolonged the up-regulation of GSK-3beta pS9 for at least 8 h. However, this action of 17beta-estradiol was abrogated by PKA inhibitor H-89, AKT inhibitor LY294002, and MAPK inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	AKT serine/threonine kinase 1	Rattus norvegicus	176-179
23660824-10	2013	However, LY294002, a PI3K inhibitor, attenuated the anti-apoptotic effect of salidroside and blocked the increase of Akt and mTOR; however, did not affect the antioxidative effect of salidroside.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	117-120
23660824-10	2013	However, LY294002, a PI3K inhibitor, attenuated the anti-apoptotic effect of salidroside and blocked the increase of Akt and mTOR; however, did not affect the antioxidative effect of salidroside.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	mechanistic target of rapamycin kinase	Homo sapiens	125-129
23686980-11	2013	LY294002, but not PD98059, abolished the postconditioning-induced decreases in the assembly of glutamatergic kainate receptor subunit 2-postsynaptic density protein-95-mixed lineage kinase 3 complex and in the mixed lineage kinase 3-c-Jun N-terminal kinase 3 signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase kinase kinase 11	Rattus norvegicus	168-190
23686980-11	2013	LY294002, but not PD98059, abolished the postconditioning-induced decreases in the assembly of glutamatergic kainate receptor subunit 2-postsynaptic density protein-95-mixed lineage kinase 3 complex and in the mixed lineage kinase 3-c-Jun N-terminal kinase 3 signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase kinase kinase 11	Rattus norvegicus	210-232
23686980-11	2013	LY294002, but not PD98059, abolished the postconditioning-induced decreases in the assembly of glutamatergic kainate receptor subunit 2-postsynaptic density protein-95-mixed lineage kinase 3 complex and in the mixed lineage kinase 3-c-Jun N-terminal kinase 3 signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen activated protein kinase 10	Rattus norvegicus	233-258
23686980-12	2013	Akt inhibitor IV, a specific Akt inhibitor, showed the same effects as LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Rattus norvegicus	0-3
23361188-11	2013	Moreover, LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, could sharply block the effect of E2 in reducing the percentage of apoptotic cells resistance to H(2)O(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	22-51
23361188-12	2013	And the attenuation of Bax, the reduced activities of caspases 9/3 and the impeded release of mitochondrial cytochrome c mediated by E2 resistance to H(2)O(2) damage were significantly retrieved by LY294002 administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	198-206	BCL2 associated X, apoptosis regulator	Homo sapiens	23-26
23361188-12	2013	And the attenuation of Bax, the reduced activities of caspases 9/3 and the impeded release of mitochondrial cytochrome c mediated by E2 resistance to H(2)O(2) damage were significantly retrieved by LY294002 administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	198-206	caspase 9	Homo sapiens	54-66
23361188-12	2013	And the attenuation of Bax, the reduced activities of caspases 9/3 and the impeded release of mitochondrial cytochrome c mediated by E2 resistance to H(2)O(2) damage were significantly retrieved by LY294002 administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	198-206	cytochrome c, somatic	Homo sapiens	108-120
23624876-7	2013	Interestingly, LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, blocked the increase in phosphorylation of Akt and abolished the neuroprotection associated with 4-HBA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	118-121
23328930-8	2013	Activation of PI3K/Akt signaling pathway exists in TNF-alpha-induced production of IL-1beta and MMP3 on RA FLS, which is hampered by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Homo sapiens	19-22
23328930-8	2013	Activation of PI3K/Akt signaling pathway exists in TNF-alpha-induced production of IL-1beta and MMP3 on RA FLS, which is hampered by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	tumor necrosis factor	Homo sapiens	51-60
23328930-8	2013	Activation of PI3K/Akt signaling pathway exists in TNF-alpha-induced production of IL-1beta and MMP3 on RA FLS, which is hampered by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	interleukin 1 beta	Homo sapiens	83-91
23328930-8	2013	Activation of PI3K/Akt signaling pathway exists in TNF-alpha-induced production of IL-1beta and MMP3 on RA FLS, which is hampered by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	matrix metallopeptidase 3	Homo sapiens	96-100
23328930-9	2013	Immunofluorescence staining showed that TNF-alpha alone increased the production of P-Akt, whereas LY294002 and 50 muM resveratrol suppressed the TNF-alpha-stimulated expression of P-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	tumor necrosis factor	Homo sapiens	146-155
23328930-9	2013	Immunofluorescence staining showed that TNF-alpha alone increased the production of P-Akt, whereas LY294002 and 50 muM resveratrol suppressed the TNF-alpha-stimulated expression of P-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	AKT serine/threonine kinase 1	Homo sapiens	183-186
23815230-6	2013	LGI3 treatment increased beta-catenin protein and nuclear localization, whereas LY294002 prevented LGI3-induced focal adhesion kinase and Akt activation as well as beta-catenin accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	138-141
23815230-6	2013	LGI3 treatment increased beta-catenin protein and nuclear localization, whereas LY294002 prevented LGI3-induced focal adhesion kinase and Akt activation as well as beta-catenin accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	catenin beta 1	Homo sapiens	164-176
23815230-6	2013	LGI3 treatment increased beta-catenin protein and nuclear localization, whereas LY294002 prevented LGI3-induced focal adhesion kinase and Akt activation as well as beta-catenin accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	leucine rich repeat LGI family member 3	Homo sapiens	99-103
23685155-8	2013	The increase of Orai1 protein abundance is insensitive to inhibition of transcription with actinomycin (4 mug/ml), but is significantly blunted by inhibition of translation with puromycin (100 nM) and by inhibition of PI3K with wortmannin (100 nM) or LY294002 (25 muM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	ORAI calcium release-activated calcium modulator 1	Homo sapiens	16-21
23806079-11	2013	Moreover, the migration and invasion promoted by L1cam overexpression in gastric cancer cells could be abolished by either application of LY294002 (a phosphoinositide-3-kinase inhibitor) or knockdown of endogenous Akt by small interfering RNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	L1 cell adhesion molecule	Homo sapiens	49-54
23799989-7	2013	When LY294002, a specific inhibitor of phospholipids phthalocyanine inositol 3-kinase, was added to the EPO treated rats, the injury changes of renal cell were becoming more pronounced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	erythropoietin	Rattus norvegicus	104-107
24499047-11	2013	LY294002 attenuated glutamine-mediated increases in fibronectin and in HSP70 expression after hyperthermia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	fibronectin 1	Homo sapiens	52-63
24499047-11	2013	LY294002 attenuated glutamine-mediated increases in fibronectin and in HSP70 expression after hyperthermia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	71-76
23485815-7	2013	Selective inhibition of PI3K using LY294002 abolished PF-mediated phosphorylation of Akt-1 and NPC protection upon oxidative stress.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	85-90
23643356-9	2013	Inhibition of Akt signaling by specific inhibitor LY 294002 blocked miR-21-induced fibrogenic effects in LX-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	AKT serine/threonine kinase 1	Homo sapiens	14-17
23764850-7	2013	siRNA gene silencing of ephrin B2 (EFNB2), and inhibition of Akt phosphorylation using LY294002, demonstrated that their sequential activation was responsible for the increases observed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
23524143-7	2013	Knockdown of mGluR5 or inhibition of PI3K by LY294002 blocked ICA induced cardiomyogenesis via repressing mGluR5 pathway, reducing ROS and NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	glutamate receptor, ionotropic, kainate 1	Mus musculus	106-112
23381397-4	2013	Analysis with the PI3K-specific inhibitor LY294002 confirmed that PI3K acted as the upstream activator for the virus-induced activation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	AKT serine/threonine kinase 1	Homo sapiens	139-142
23381397-7	2013	Moreover, the suppression of phosphorylated Akt with LY294002 significantly inhibited the virus-induced cytopathic effect (CPE) on MARC-145 cells, but it had a negligible effect on virus propagation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	44-47
23643356-9	2013	Inhibition of Akt signaling by specific inhibitor LY 294002 blocked miR-21-induced fibrogenic effects in LX-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	microRNA 21	Homo sapiens	68-74
23054210-7	2013	Wortmannin and LY294002, two PI3 kinase inhibitors, inhibited Akt but not JNK phosphorylation in ras-transformed cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	62-65
23317035-9	2013	A PI3K specific inhibitor (LY294002), Akt inhibitor VIII (Akti) and NF-kappaB inhibitors (Bay-11-7082 and MG-132) attenuated the induction of ICAM-1 by PGE2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	intercellular adhesion molecule 1	Mus musculus	142-148
23524337-10	2013	Further, Livin-induced migration and invasion could be abolished by either the application of the phosphoinositide-3-kinase inhibitor LY294002 or knockdown of AKT expression using small-interfering RNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	baculoviral IAP repeat containing 7	Homo sapiens	9-14
23588932-6	2013	The normal HKC cells and HKC-SOEV cells were treated with TGF-beta1 (5 microg/l) or/and LY294002 (20 micromol/l) for 24 and 48 h (LY294002 blocks the effect of VEGF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	transforming growth factor beta 1	Homo sapiens	58-67
23588932-6	2013	The normal HKC cells and HKC-SOEV cells were treated with TGF-beta1 (5 microg/l) or/and LY294002 (20 micromol/l) for 24 and 48 h (LY294002 blocks the effect of VEGF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	vascular endothelial growth factor A	Homo sapiens	160-164
23588932-14	2013	Importantly, treatment with LY294002 significantly diminished the effect of VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	vascular endothelial growth factor A	Homo sapiens	76-80
23438367-8	2013	LY294002 induced p27 expression in HCT15 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	dynactin subunit 6	Homo sapiens	17-20
23386415-7	2013	Regarding FRO ATC cells, the decrement of cell viability, the increment of cleaved PARP-1 protein levels, and the decrement of phospho-Src protein levels were shown in p21 siRNA- or LY294002-pretreated cells compared to SU6656-treated control cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	poly(ADP-ribose) polymerase 1	Homo sapiens	83-89
23386415-7	2013	Regarding FRO ATC cells, the decrement of cell viability, the increment of cleaved PARP-1 protein levels, and the decrement of phospho-Src protein levels were shown in p21 siRNA- or LY294002-pretreated cells compared to SU6656-treated control cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	135-138
23200321-10	2013	In resistant cell lines harboring PIK3CA mutations, a PI3K inhibitor, LY294002, or AKT siRNA reduced cell viability with an additive effect demonstrated in combination with gefitinib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	34-40
23246160-12	2013	Furthermore, a PI3-kinase inhibitor (LY294002) and a p38 MAPK inhibitor (SB203580) both significantly diminished PKC activation and p38 MAPK and Akt phosphorylation; in contrast, a PKC inhibitor (RO318220) did not diminish p38 MAPK or Akt phosphorylation stimulated by collagen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	thymoma viral proto-oncogene 1	Mus musculus	235-238
23246160-12	2013	Furthermore, a PI3-kinase inhibitor (LY294002) and a p38 MAPK inhibitor (SB203580) both significantly diminished PKC activation and p38 MAPK and Akt phosphorylation; in contrast, a PKC inhibitor (RO318220) did not diminish p38 MAPK or Akt phosphorylation stimulated by collagen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	thymoma viral proto-oncogene 1	Mus musculus	145-148
23246160-12	2013	Furthermore, a PI3-kinase inhibitor (LY294002) and a p38 MAPK inhibitor (SB203580) both significantly diminished PKC activation and p38 MAPK and Akt phosphorylation; in contrast, a PKC inhibitor (RO318220) did not diminish p38 MAPK or Akt phosphorylation stimulated by collagen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	mitogen-activated protein kinase 14	Mus musculus	132-135
23595342-9	2013	Furthermore, inhibition of the PI3K/AKT pathway by the inhibitor LY294002 led to attenuated differentiation, while differentiation remained stable with the inhibition of the MAPK/ERK pathway by PD0325901.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	36-39
23200321-11	2013	Additionally, LY294002 alone and in combination with gefitinib, was effective at treating PIK3CA mutated tumors xenografted into nude mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	90-96
23595988-7	2013	The inhibition of p85alpha expression by siRNA or the inhibition of PI3K by LY294002 prevents the expression of Pdx1, Ngn3, and MafA and the reprogramming to insulin-producing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	pancreatic and duodenal homeobox 1	Mus musculus	112-116
23595988-7	2013	The inhibition of p85alpha expression by siRNA or the inhibition of PI3K by LY294002 prevents the expression of Pdx1, Ngn3, and MafA and the reprogramming to insulin-producing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	neurogenin 3	Mus musculus	118-122
23595988-7	2013	The inhibition of p85alpha expression by siRNA or the inhibition of PI3K by LY294002 prevents the expression of Pdx1, Ngn3, and MafA and the reprogramming to insulin-producing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	Mus musculus	128-132
23708104-10	2013	In addition, the inhibitor of PI3K/Akt signaling pathway, LY294002, dramatically inhibited the growth of Ubc9 overexpressing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Homo sapiens	35-38
23714001-12	2013	Blockage of both pathways by specific inhibitors (LY294002 and PDTC, respectively) abrogated Id1-enhanced EPC angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	inhibitor of DNA binding 1, HLH protein	Homo sapiens	93-96
23624506-7	2013	Suppression of Akt phosphorylation and telomerase activity was also observed with PI3K inhibitor LY294002 further supporting the hypothesis that Akt signaling is involved in suppression of AR42-induced inhibition of telomerase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	15-18
23624506-7	2013	Suppression of Akt phosphorylation and telomerase activity was also observed with PI3K inhibitor LY294002 further supporting the hypothesis that Akt signaling is involved in suppression of AR42-induced inhibition of telomerase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	145-148
23708104-10	2013	In addition, the inhibitor of PI3K/Akt signaling pathway, LY294002, dramatically inhibited the growth of Ubc9 overexpressing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	ubiquitin conjugating enzyme E2 I	Homo sapiens	105-109
22884970-8	2013	The food intake enhancing effects of VHPC ghrelin were blocked by co-administration of a phosphoinositide 3-kinase (PI3K) inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	ghrelin and obestatin prepropeptide	Rattus norvegicus	42-49
23357110-5	2013	LY294002, a phosphatidylinositol 3-kinase inhibitor, inhibited the expression of insulin-induced increases in SIRT1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin	Homo sapiens	81-88
23357110-5	2013	LY294002, a phosphatidylinositol 3-kinase inhibitor, inhibited the expression of insulin-induced increases in SIRT1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	sirtuin 1	Homo sapiens	110-115
22751110-9	2013	Inhibition of MEK 1/2 with UO126 completely restored ERbeta growth-inhibitory effects, whereas inhibition of PI3K by LY294002 inhibited ERbeta-induced proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	estrogen receptor 2 (beta)	Mus musculus	136-142
23557855-3	2013	We further observed the effect of specific inhibitor of PI3K(LY294002) and specific inhibitor of Notch(DAPT) on the proliferation of such CD4(+) T lymphocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	CD4 antigen	Mus musculus	138-141
23557855-5	2013	Both LY294002 and DAPT inhibit the proliferation of CD4(+) T lymphocytes in a time- and dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	CD4 antigen	Mus musculus	52-55
23557855-6	2013	Furthermore, LY294002 and DAPT have additive effect in down-regulation of cyclinD1 and upregulation of p27kip1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cyclin D1	Mus musculus	74-82
23557855-6	2013	Furthermore, LY294002 and DAPT have additive effect in down-regulation of cyclinD1 and upregulation of p27kip1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cyclin-dependent kinase inhibitor 1B	Mus musculus	103-110
23562854-8	2013	Glucose deprivation induced activation of PI3K-Akt-GSK3beta, p38 and AMPK, and inhibition of these pathways using LY294002, SB203580 and compound C significantly inhibited glucose deprivation-induced tPA down-regulation, demonstrating the essential role of these pathways in tPA regulation in glucose-deprived astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	69-73
23562854-8	2013	Glucose deprivation induced activation of PI3K-Akt-GSK3beta, p38 and AMPK, and inhibition of these pathways using LY294002, SB203580 and compound C significantly inhibited glucose deprivation-induced tPA down-regulation, demonstrating the essential role of these pathways in tPA regulation in glucose-deprived astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	plasminogen activator, tissue type	Rattus norvegicus	200-203
23562854-8	2013	Glucose deprivation induced activation of PI3K-Akt-GSK3beta, p38 and AMPK, and inhibition of these pathways using LY294002, SB203580 and compound C significantly inhibited glucose deprivation-induced tPA down-regulation, demonstrating the essential role of these pathways in tPA regulation in glucose-deprived astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	plasminogen activator, tissue type	Rattus norvegicus	275-278
23500546-5	2013	It was found that mRNA, protein, and current density of K(Ca)3.1 channels were greatly enhanced in cultured cardiac fibroblasts treated with 1 muM Ang II, and the effects were countered by the angiotensin type 1 receptor (AT1R) blocker losartan, the p38-MAPK inhibitor SB203580, the ERK1/2 inhibitor PD98059, and the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	336-344	angiotensinogen	Rattus norvegicus	147-153
23500546-5	2013	It was found that mRNA, protein, and current density of K(Ca)3.1 channels were greatly enhanced in cultured cardiac fibroblasts treated with 1 muM Ang II, and the effects were countered by the angiotensin type 1 receptor (AT1R) blocker losartan, the p38-MAPK inhibitor SB203580, the ERK1/2 inhibitor PD98059, and the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	336-344	angiotensin II receptor, type 1a	Rattus norvegicus	193-220
23500546-5	2013	It was found that mRNA, protein, and current density of K(Ca)3.1 channels were greatly enhanced in cultured cardiac fibroblasts treated with 1 muM Ang II, and the effects were countered by the angiotensin type 1 receptor (AT1R) blocker losartan, the p38-MAPK inhibitor SB203580, the ERK1/2 inhibitor PD98059, and the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	336-344	angiotensin II receptor, type 1a	Rattus norvegicus	222-226
23353591-6	2013	Furthermore, a phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 significantly suppressed LPS-induced NF-kappaB p65 nuclear translocation, iNOS expression, and NO production, which was also mimicked by pretreatment with DSC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	108-117
23353591-6	2013	Furthermore, a phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 significantly suppressed LPS-induced NF-kappaB p65 nuclear translocation, iNOS expression, and NO production, which was also mimicked by pretreatment with DSC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	118-121
23353591-6	2013	Furthermore, a phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 significantly suppressed LPS-induced NF-kappaB p65 nuclear translocation, iNOS expression, and NO production, which was also mimicked by pretreatment with DSC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	nitric oxide synthase 2, inducible	Mus musculus	145-149
23691130-8	2013	Furthermore, inhibiting AKT phosphorylation by LY294002 rescued the phenotype induced by SENP2 deficiency in MEFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	24-27
23671658-4	2013	PTTH-inhibited AMPK phosphorylation appeared to be partially reversed by treatment with LY294002, indicating involvement of phosphatidylinositol 3-kinase (PI3K) signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	prothoracicotropic hormone	Bombyx mori	0-4
23582786-6	2013	Then, LY294002, an inhibitor of PI3K, was added into the culture medium of pCDNA3.1(+)-Rack1-Hca-P cells and their biological behaviors observed further.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	receptor for activated C kinase 1	Mus musculus	87-92
23582786-9	2013	In addition, the expression of Gsn, Rac1 and Jnk1 of pCDNA3.1(+)-Rack1-Hca-P cells also decreased after pretreated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	Rac family small GTPase 1	Mus musculus	36-40
23582786-7	2013	Moreover, the expression of Jnk1, Rac1 and Gsn of pCDNA3.1(+)-Rack1-Hca-P cells were detected by western blot after pretreated with various doses of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	mitogen-activated protein kinase 8	Mus musculus	28-32
23582786-9	2013	In addition, the expression of Gsn, Rac1 and Jnk1 of pCDNA3.1(+)-Rack1-Hca-P cells also decreased after pretreated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	mitogen-activated protein kinase 8	Mus musculus	45-49
23582786-7	2013	Moreover, the expression of Jnk1, Rac1 and Gsn of pCDNA3.1(+)-Rack1-Hca-P cells were detected by western blot after pretreated with various doses of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	Rac family small GTPase 1	Mus musculus	34-38
23582786-9	2013	In addition, the expression of Gsn, Rac1 and Jnk1 of pCDNA3.1(+)-Rack1-Hca-P cells also decreased after pretreated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	receptor for activated C kinase 1	Mus musculus	65-70
23582786-7	2013	Moreover, the expression of Jnk1, Rac1 and Gsn of pCDNA3.1(+)-Rack1-Hca-P cells were detected by western blot after pretreated with various doses of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	gelsolin	Mus musculus	43-46
23582786-7	2013	Moreover, the expression of Jnk1, Rac1 and Gsn of pCDNA3.1(+)-Rack1-Hca-P cells were detected by western blot after pretreated with various doses of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	receptor for activated C kinase 1	Mus musculus	62-67
23582786-8	2013	As a result, the proliferation, migration and invasion of pCDNA3.1(+)-Rack1-Hca-P cells were significantly enhanced and could be inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	receptor for activated C kinase 1	Mus musculus	70-75
23582786-9	2013	In addition, the expression of Gsn, Rac1 and Jnk1 of pCDNA3.1(+)-Rack1-Hca-P cells also decreased after pretreated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	gelsolin	Mus musculus	31-34
23564227-7	2013	Treatment with the PI3K inhibitor LY294002 abolished Der f 2-induced activation of Akt and NF-kappaB and the expression of IL-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	83-86
23515290-13	2013	Pretreatment with L161982 or AH23848 blocked the stimulatory effects of PGE2 and TGF-beta on cell migration, whereas LY294002 or rapamycin completely eliminated PGE2, TGF-beta, and epidermal growth factor-induced migration in PC3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	transforming growth factor beta 1	Homo sapiens	167-175
23515290-12	2013	PGE2 and TGF-beta induced phosphorylation of AKT, which was blocked by antagonists of PGE2 (EP4) receptors (L161982, AH23848) and PI3K inhibitor (LY294002) in PC3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	transforming growth factor beta 1	Homo sapiens	9-17
23515290-12	2013	PGE2 and TGF-beta induced phosphorylation of AKT, which was blocked by antagonists of PGE2 (EP4) receptors (L161982, AH23848) and PI3K inhibitor (LY294002) in PC3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	AKT serine/threonine kinase 1	Homo sapiens	45-48
23515290-12	2013	PGE2 and TGF-beta induced phosphorylation of AKT, which was blocked by antagonists of PGE2 (EP4) receptors (L161982, AH23848) and PI3K inhibitor (LY294002) in PC3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	prostaglandin E receptor 4	Homo sapiens	92-95
23403163-0	2013	Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	BCL2 like 11	Homo sapiens	172-175
23403163-8	2013	RESULTS: The combination of OBP-801/YM753 and LY294002 significantly inhibited the cell growth on comparison with each agent alone and synergistically increased apoptosis with the induction of Bim, a well-known apoptosis inducer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	BCL2 like 11	Homo sapiens	193-196
23403163-10	2013	Moreover, the apoptosis-inducing effect of OBP-801/YM753 with LY294002 was more potent than that of SAHA with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	odorant binding protein 2A	Homo sapiens	43-46
23564227-7	2013	Treatment with the PI3K inhibitor LY294002 abolished Der f 2-induced activation of Akt and NF-kappaB and the expression of IL-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	nuclear factor kappa B subunit 1	Homo sapiens	91-100
23564227-7	2013	Treatment with the PI3K inhibitor LY294002 abolished Der f 2-induced activation of Akt and NF-kappaB and the expression of IL-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	interleukin 13	Homo sapiens	123-128
23435959-5	2013	LY294002 (PI3-kinase inhibitor) and L-NAME (NOS inhibitor) significantly inhibited reverse D-4F mediated improvement of EPCs biological functions, and LY294002 significantly decreased reverse D-4F stimulated activation of phospho-AKT (473) and phospho-eNOS (1177).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	230-233
23364610-6	2013	The action of bLF on eNOS phosphorylation was abolished by both LY294002, a phosphatidylinositol 3-kinase inhibitor, and 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo [3,4-d]pyrimidine (PP2), an Src inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	nitric oxide synthase 3, endothelial cell	Mus musculus	21-25
23364610-6	2013	The action of bLF on eNOS phosphorylation was abolished by both LY294002, a phosphatidylinositol 3-kinase inhibitor, and 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo [3,4-d]pyrimidine (PP2), an Src inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	neuropeptide Y receptor Y6	Mus musculus	193-196
23364610-6	2013	The action of bLF on eNOS phosphorylation was abolished by both LY294002, a phosphatidylinositol 3-kinase inhibitor, and 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo [3,4-d]pyrimidine (PP2), an Src inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	Rous sarcoma oncogene	Mus musculus	202-205
23218924-7	2013	PI3K inhibitor LY294002 attenuated ghrelin-induced EPC migration, phosphorylation of Akt and eNOS, and NO production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
23218924-7	2013	PI3K inhibitor LY294002 attenuated ghrelin-induced EPC migration, phosphorylation of Akt and eNOS, and NO production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	nitric oxide synthase 3	Rattus norvegicus	93-97
23435959-5	2013	LY294002 (PI3-kinase inhibitor) and L-NAME (NOS inhibitor) significantly inhibited reverse D-4F mediated improvement of EPCs biological functions, and LY294002 significantly decreased reverse D-4F stimulated activation of phospho-AKT (473) and phospho-eNOS (1177).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 3, endothelial cell	Mus musculus	252-256
23435959-5	2013	LY294002 (PI3-kinase inhibitor) and L-NAME (NOS inhibitor) significantly inhibited reverse D-4F mediated improvement of EPCs biological functions, and LY294002 significantly decreased reverse D-4F stimulated activation of phospho-AKT (473) and phospho-eNOS (1177).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	thymoma viral proto-oncogene 1	Mus musculus	230-233
23435959-5	2013	LY294002 (PI3-kinase inhibitor) and L-NAME (NOS inhibitor) significantly inhibited reverse D-4F mediated improvement of EPCs biological functions, and LY294002 significantly decreased reverse D-4F stimulated activation of phospho-AKT (473) and phospho-eNOS (1177).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	nitric oxide synthase 3, endothelial cell	Mus musculus	252-256
23590596-9	2013	Targeting PI3K/Akt signaling by the inhibitor LY294002 (30 muM) significantly decreased the protein expression as well as DNA binding activity of HIF-1alpha and restored the apoptosis-inducing ability of cells in hypoxia Additionally, pretreatment with LY294002 sensitized A204 and A673 cells to TRAIL or doxorubicin induced apoptosis under hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	15-18
23546450-8	2013	Results of the present study also demonstrated that Akt signaling is involved in the ADR resistance of breast cancer cells since LY294002, an inhibitor of Akt signaling, partially restored the sensitivity of MCF-7/ADR cells to ADR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	AKT serine/threonine kinase 1	Homo sapiens	52-55
23546450-8	2013	Results of the present study also demonstrated that Akt signaling is involved in the ADR resistance of breast cancer cells since LY294002, an inhibitor of Akt signaling, partially restored the sensitivity of MCF-7/ADR cells to ADR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	AKT serine/threonine kinase 1	Homo sapiens	155-158
23379699-9	2013	NO generation, the increase in FGF-2 expression, and the stimulation of vasculogenesis/angiogenesis by alpha2M were blunted by the NO synthase inhibitor L-NAME, the ERK1/2 inhibitor PD98059, and the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	alpha-2-macroglobulin	Mus musculus	103-110
23595747-8	2013	Axonal application of LY294002, a phosphoinositide3-kinase inhibitor, or rapamycin, an mTOR inhibitor, abolished axonal outgrowth enhanced by overexpression of the miR-17-92 cluster.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	miR-17-92a-1 cluster host gene	Homo sapiens	164-173
23518641-8	2013	Further, EPO activates the PI3K and ERK1/2 pathways in cultured hippocampal neurons, and the PI3K/Akt inhibitor LY294002 and ERK1/2 inhibitor U0126 both blocked, at least in part, the suppressive effect of exogenous EPO on KA-induced calcium currents.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	erythropoietin	Rattus norvegicus	9-12
23518641-8	2013	Further, EPO activates the PI3K and ERK1/2 pathways in cultured hippocampal neurons, and the PI3K/Akt inhibitor LY294002 and ERK1/2 inhibitor U0126 both blocked, at least in part, the suppressive effect of exogenous EPO on KA-induced calcium currents.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
23518641-8	2013	Further, EPO activates the PI3K and ERK1/2 pathways in cultured hippocampal neurons, and the PI3K/Akt inhibitor LY294002 and ERK1/2 inhibitor U0126 both blocked, at least in part, the suppressive effect of exogenous EPO on KA-induced calcium currents.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	erythropoietin	Rattus norvegicus	216-219
23590596-9	2013	Targeting PI3K/Akt signaling by the inhibitor LY294002 (30 muM) significantly decreased the protein expression as well as DNA binding activity of HIF-1alpha and restored the apoptosis-inducing ability of cells in hypoxia Additionally, pretreatment with LY294002 sensitized A204 and A673 cells to TRAIL or doxorubicin induced apoptosis under hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	latexin	Homo sapiens	59-62
23590596-9	2013	Targeting PI3K/Akt signaling by the inhibitor LY294002 (30 muM) significantly decreased the protein expression as well as DNA binding activity of HIF-1alpha and restored the apoptosis-inducing ability of cells in hypoxia Additionally, pretreatment with LY294002 sensitized A204 and A673 cells to TRAIL or doxorubicin induced apoptosis under hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-156
23590596-9	2013	Targeting PI3K/Akt signaling by the inhibitor LY294002 (30 muM) significantly decreased the protein expression as well as DNA binding activity of HIF-1alpha and restored the apoptosis-inducing ability of cells in hypoxia Additionally, pretreatment with LY294002 sensitized A204 and A673 cells to TRAIL or doxorubicin induced apoptosis under hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	TNF superfamily member 10	Homo sapiens	296-301
23590596-9	2013	Targeting PI3K/Akt signaling by the inhibitor LY294002 (30 muM) significantly decreased the protein expression as well as DNA binding activity of HIF-1alpha and restored the apoptosis-inducing ability of cells in hypoxia Additionally, pretreatment with LY294002 sensitized A204 and A673 cells to TRAIL or doxorubicin induced apoptosis under hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	253-261	AKT serine/threonine kinase 1	Homo sapiens	15-18
23590596-9	2013	Targeting PI3K/Akt signaling by the inhibitor LY294002 (30 muM) significantly decreased the protein expression as well as DNA binding activity of HIF-1alpha and restored the apoptosis-inducing ability of cells in hypoxia Additionally, pretreatment with LY294002 sensitized A204 and A673 cells to TRAIL or doxorubicin induced apoptosis under hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	253-261	latexin	Homo sapiens	59-62
23590596-9	2013	Targeting PI3K/Akt signaling by the inhibitor LY294002 (30 muM) significantly decreased the protein expression as well as DNA binding activity of HIF-1alpha and restored the apoptosis-inducing ability of cells in hypoxia Additionally, pretreatment with LY294002 sensitized A204 and A673 cells to TRAIL or doxorubicin induced apoptosis under hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	253-261	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-156
23466500-8	2013	Inhibition of Akt using PI3K inhibitor LY 294002 could abrogate miR-21 induced cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	AKT serine/threonine kinase 1	Homo sapiens	14-17
23353699-7	2013	In addition, TNF-alpha-stimulated Akt phosphorylation was inhibited by PP1, AG1478, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	tumor necrosis factor	Rattus norvegicus	13-22
23353699-7	2013	In addition, TNF-alpha-stimulated Akt phosphorylation was inhibited by PP1, AG1478, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Rattus norvegicus	34-37
23353699-9	2013	Finally, we showed that, in H9c2 cells, TNF-alpha-stimulated AP-1 promoter activity, c-Jun mRNA expression, and c-Jun phosphorylation were attenuated by PP1, AG1478, AG1296, LY294002, SB202190, SP600125, or U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	tumor necrosis factor	Rattus norvegicus	40-49
23353699-9	2013	Finally, we showed that, in H9c2 cells, TNF-alpha-stimulated AP-1 promoter activity, c-Jun mRNA expression, and c-Jun phosphorylation were attenuated by PP1, AG1478, AG1296, LY294002, SB202190, SP600125, or U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	neuropeptide Y receptor Y4	Rattus norvegicus	153-156
23328306-8	2013	In addition, inhibiting the PI3K/Akt pathway by LY294002 significantly enhanced the suppression of PCNA expression and Akt activation by CPT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
23328306-8	2013	In addition, inhibiting the PI3K/Akt pathway by LY294002 significantly enhanced the suppression of PCNA expression and Akt activation by CPT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	proliferating cell nuclear antigen	Rattus norvegicus	99-103
23328306-8	2013	In addition, inhibiting the PI3K/Akt pathway by LY294002 significantly enhanced the suppression of PCNA expression and Akt activation by CPT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Rattus norvegicus	119-122
23466500-8	2013	Inhibition of Akt using PI3K inhibitor LY 294002 could abrogate miR-21 induced cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	microRNA 21	Homo sapiens	64-70
23239345-5	2013	An increase in phosphorylated cAMP response element-binding protein (CREB) was also observed after exposure of PC12 cells to METH, which was inhibited by a PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	cAMP responsive element binding protein 1	Rattus norvegicus	30-67
23375756-7	2013	RESULTS: TRAIL + LY294002, but not TRAIL alone, induced monolayer hyperpermeability (P &lt; .05), and caspase-3 activity (P &lt; .05), and disrupted the adherens junctions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	caspase 3	Homo sapiens	102-111
23021350-10	2013	Treatment with the PI3K inhibitor, LY294002, and the NF-kappaB inhibitor, Bay11-7082, suppressed ZnCl2-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	heme oxygenase 1	Mus musculus	111-115
23328493-6	2013	In addition, DSC concentration-dependently induced HO-1 expression associated with nuclear translocation of nuclear factor-erythroid 2 related factor 2 (Nrf-2), while the effect of DSC was inhibited by a phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	247-255	desmocollin 3	Homo sapiens	13-16
23328493-6	2013	In addition, DSC concentration-dependently induced HO-1 expression associated with nuclear translocation of nuclear factor-erythroid 2 related factor 2 (Nrf-2), while the effect of DSC was inhibited by a phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	247-255	heme oxygenase 1	Homo sapiens	51-55
23328493-6	2013	In addition, DSC concentration-dependently induced HO-1 expression associated with nuclear translocation of nuclear factor-erythroid 2 related factor 2 (Nrf-2), while the effect of DSC was inhibited by a phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	247-255	NFE2 like bZIP transcription factor 2	Homo sapiens	153-158
23328493-6	2013	In addition, DSC concentration-dependently induced HO-1 expression associated with nuclear translocation of nuclear factor-erythroid 2 related factor 2 (Nrf-2), while the effect of DSC was inhibited by a phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	247-255	desmocollin 3	Homo sapiens	181-184
23524565-7	2013	RESULTS: Treatment of the cells with HG, H2O2, or TGF-beta1 (5 ng/mL) significantly increased the NO level that was substantially inhibited by co-treatment with the NADPH oxidase inhibitor diphenylene iodonium (DPI), TGF-beta1 inhibitor SB431542, or PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	265-273	transforming growth factor, beta 1	Rattus norvegicus	50-59
23524565-9	2013	Furthermore, the treatment with HG or H2O2 significantly increased the expression of phosphorylated Akt and iNOS and cell proliferation rate, which was blocked by co-treatment with DPI, SB431542, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-207	AKT serine/threonine kinase 1	Rattus norvegicus	100-103
23524565-9	2013	Furthermore, the treatment with HG or H2O2 significantly increased the expression of phosphorylated Akt and iNOS and cell proliferation rate, which was blocked by co-treatment with DPI, SB431542, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-207	nitric oxide synthase 2	Rattus norvegicus	108-112
23524565-10	2013	Moreover, the treatment with HG or H2O2 significantly inhibited Bim protein and mRNA expression, which was reversed by co-treatment with DPI, SB431542, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	Bcl2-like 11	Rattus norvegicus	64-67
23239345-5	2013	An increase in phosphorylated cAMP response element-binding protein (CREB) was also observed after exposure of PC12 cells to METH, which was inhibited by a PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	cAMP responsive element binding protein 1	Rattus norvegicus	69-73
23188122-6	2013	The decrease in caspase-3 activity and caused by CCE were blocked by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase, the upstream kinase of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	caspase 3	Homo sapiens	16-25
23596468-4	2013	PODXL overexpression in SW1783 cells significantly increased cell invasion, matrix metalloproteinase-9 (MMP-9) expression, cell survival against temozolomide-induced apoptotic stress, and phosphorylation of Akt at serine 473 (ser473), which was abolished by the selective phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (LY).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	319-327	podocalyxin like	Homo sapiens	0-5
23188122-6	2013	The decrease in caspase-3 activity and caused by CCE were blocked by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase, the upstream kinase of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	157-160
23299243-8	2013	After leptin injection, ATP, leptin, and p-Akt levels were significantly increased, LDH levels and lactic acid/pyruvate ratio were noticeably reduced, and histopathologic injuries were alleviated, which were all reversed by the PI(3)K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	leptin	Homo sapiens	6-12
23626478-9	2013	Concurrent treatment with the MEK1/2 inhibitors, PD98059 or U0126 completely inhibited recombinant IGFBP-5-induced VSMC proliferation in WKY, while concurrent treatment with the phosphatidylinositol-3 kinase inhibitor, LY294002, had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	mitogen activated protein kinase kinase 1	Rattus norvegicus	30-36
23626478-9	2013	Concurrent treatment with the MEK1/2 inhibitors, PD98059 or U0126 completely inhibited recombinant IGFBP-5-induced VSMC proliferation in WKY, while concurrent treatment with the phosphatidylinositol-3 kinase inhibitor, LY294002, had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	insulin-like growth factor binding protein 5	Rattus norvegicus	99-106
23302722-9	2013	In cultured macrophages, adiponectin directly promoted macrophage migration: a process blocked by the PI3 kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	adiponectin, C1Q and collagen domain containing	Mus musculus	25-36
23376356-4	2013	LY294002, a specific PI3K/AKT inhibitor, selectively activated the p38 MAPK kinase pathway and enhanced c-Jun phosphorylation, but did not activate JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	26-29
23376356-4	2013	LY294002, a specific PI3K/AKT inhibitor, selectively activated the p38 MAPK kinase pathway and enhanced c-Jun phosphorylation, but did not activate JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen activated protein kinase 14	Rattus norvegicus	67-70
23376356-5	2013	The pharmacological inhibitors SB203580 (p38 inhibitor) and SP600125 (a JNK inhibitor) protected primary cultures of rat CGCs from LY294002-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	mitogen activated protein kinase 14	Rattus norvegicus	41-44
23376356-5	2013	The pharmacological inhibitors SB203580 (p38 inhibitor) and SP600125 (a JNK inhibitor) protected primary cultures of rat CGCs from LY294002-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	mitogen-activated protein kinase 8	Rattus norvegicus	72-75
23391508-6	2013	However, an addition of the PI3K/Akt inhibitor LY294002 inhibited these Ghr-mediated effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	33-36
23262029-5	2013	MVNP expression in NIH3T3 cells also elevated Il-6 transcription and impaired the expression of Sirt1 mRNA both under basal conditions and upon activation of the Sirt1 upstream regulator FoxO3 by LY294002 (a PI3K/AKT inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	sirtuin 1	Mus musculus	162-167
23355370-7	2013	Interestingly, a short treatment with LY294002, an inhibitor of the PI3K/AKT pathway, specifically reverts a subset of Rh123(high) cells to the Rh123(low) phenotype, whereas treatment with inhibitors of mammalian target of rapamycin, phosphatase and tensin homolog or mitogen-activated protein kinase signaling does not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	73-76
23355370-7	2013	Interestingly, a short treatment with LY294002, an inhibitor of the PI3K/AKT pathway, specifically reverts a subset of Rh123(high) cells to the Rh123(low) phenotype, whereas treatment with inhibitors of mammalian target of rapamycin, phosphatase and tensin homolog or mitogen-activated protein kinase signaling does not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	mechanistic target of rapamycin kinase	Homo sapiens	203-232
23188704-9	2013	The PI3K inhibitor LY294002 inhibited both the phosphorylation of mTOR and upregulation of Livin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	mechanistic target of rapamycin kinase	Homo sapiens	66-70
23188704-9	2013	The PI3K inhibitor LY294002 inhibited both the phosphorylation of mTOR and upregulation of Livin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	baculoviral IAP repeat containing 7	Homo sapiens	91-96
23789097-7	2013	The inhibition of PI3K or Akt activities, by the specific kinase inhibitors (wortmannin, LY294002 or SH6), stimulates Ostf1 expression, while a reduction of GSK3beta activity by LiCl reduces Ostf1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	osteoclast stimulating factor 1	Equus caballus	118-123
23789097-7	2013	The inhibition of PI3K or Akt activities, by the specific kinase inhibitors (wortmannin, LY294002 or SH6), stimulates Ostf1 expression, while a reduction of GSK3beta activity by LiCl reduces Ostf1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	osteoclast stimulating factor 1	Equus caballus	191-196
23755818-9	2013	Upon the addition of LY294002, 5C11-mediated up-regulation of p-AKT was inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	64-67
23373904-0	2013	LY294002 enhances expression of proteins encoded by recombinant replication-defective adenoviruses via mTOR- and non-mTOR-dependent mechanisms.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	103-107
23373904-0	2013	LY294002 enhances expression of proteins encoded by recombinant replication-defective adenoviruses via mTOR- and non-mTOR-dependent mechanisms.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	117-121
23373904-5	2013	LY294002-induced upregulation of adenovirally delivered transgene is mediated in part by direct inhibition of mTOR protein kinase in mTORC2 signaling complex thus suggesting that anticancer drugs targeting mTOR will also enhance expression of transgenes delivered with adenoviral vectors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	110-114
23373904-5	2013	LY294002-induced upregulation of adenovirally delivered transgene is mediated in part by direct inhibition of mTOR protein kinase in mTORC2 signaling complex thus suggesting that anticancer drugs targeting mTOR will also enhance expression of transgenes delivered with adenoviral vectors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CREB regulated transcription coactivator 2	Mus musculus	133-139
23373904-5	2013	LY294002-induced upregulation of adenovirally delivered transgene is mediated in part by direct inhibition of mTOR protein kinase in mTORC2 signaling complex thus suggesting that anticancer drugs targeting mTOR will also enhance expression of transgenes delivered with adenoviral vectors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	133-137
23291213-10	2013	PI3K blockade with Ly294002 resulted in loss of MOR-mediated cytoprotective function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	opioid receptor, mu 1	Mus musculus	48-51
23352507-6	2013	In addition, inhibiting the Akt/GSK-3beta pathway by LY294002 significantly attenuated the 5-AIQ-mediated decrease in cleaved caspase-3 and Bax activation and H9c2 cell apoptosis induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
23352507-6	2013	In addition, inhibiting the Akt/GSK-3beta pathway by LY294002 significantly attenuated the 5-AIQ-mediated decrease in cleaved caspase-3 and Bax activation and H9c2 cell apoptosis induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	glycogen synthase kinase 3 beta	Rattus norvegicus	32-41
23352507-6	2013	In addition, inhibiting the Akt/GSK-3beta pathway by LY294002 significantly attenuated the 5-AIQ-mediated decrease in cleaved caspase-3 and Bax activation and H9c2 cell apoptosis induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	caspase 3	Rattus norvegicus	126-135
23352507-6	2013	In addition, inhibiting the Akt/GSK-3beta pathway by LY294002 significantly attenuated the 5-AIQ-mediated decrease in cleaved caspase-3 and Bax activation and H9c2 cell apoptosis induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	BCL2 associated X, apoptosis regulator	Rattus norvegicus	140-143
23313788-11	2013	rHuEPO increased the expression of EPOR, and upregulated the expression of pAKT/AKT and pSTAT5/STAT5 in 3T3L1 adipocytes (p&lt;0.05), which was blocked by siEPOR, the phosphatidylinositol-3-kinase (PI3K) inhibitor, LY294002, and a STAT5 inhibitor, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	AKT serine/threonine kinase 1	Homo sapiens	76-79
23330804-9	2013	The result showed that LY294002 could suppress the RNA and protein expression of TNF-alpha in RAW264.7 cells after stimulation of different particles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	tumor necrosis factor	Mus musculus	81-90
23262029-5	2013	MVNP expression in NIH3T3 cells also elevated Il-6 transcription and impaired the expression of Sirt1 mRNA both under basal conditions and upon activation of the Sirt1 upstream regulator FoxO3 by LY294002 (a PI3K/AKT inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	forkhead box O3	Mus musculus	187-192
23279934-9	2013	Furthermore, the PI3K inhibitor LY294002 pronouncedly abolished the simvastatin-mediated attenuation in caspase 3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	caspase 3	Rattus norvegicus	104-113
23161148-8	2013	AG490, PD98059, or LY294002, inhibitors specific for the intracellular signals, JAK, MAPK, and PI3K, respectively, partially blocked these IL-6 neuroprotective effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	interleukin 6	Homo sapiens	139-143
23161148-10	2013	The enhanced activation of STAT3, ERK1/2, and AKT by IL-6 was abolished by AG490, PD98059, and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	signal transducer and activator of transcription 3	Homo sapiens	27-32
23161148-10	2013	The enhanced activation of STAT3, ERK1/2, and AKT by IL-6 was abolished by AG490, PD98059, and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	mitogen-activated protein kinase 3	Homo sapiens	34-40
23161148-10	2013	The enhanced activation of STAT3, ERK1/2, and AKT by IL-6 was abolished by AG490, PD98059, and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	46-49
23161148-10	2013	The enhanced activation of STAT3, ERK1/2, and AKT by IL-6 was abolished by AG490, PD98059, and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	interleukin 6	Homo sapiens	53-57
23208610-5	2013	CCN2-stimulated phosphorylation of Akt and GSK-3beta was sensitive to inhibition of PI3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	cellular communication network factor 2	Homo sapiens	0-4
23585721-6	2013	In further experiments, an inhibitor of PI3K (LY294002) upstream of Akt increased expression of pro-inflammatory cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	68-71
22941963-8	2013	Osteoblast proliferation, as well as the level of p-Akt, was significantly inhibited by LY294002 in all three Ti surfaces.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	thymoma viral proto-oncogene 1	Mus musculus	52-55
22941963-10	2013	The expression levels of OPN and OCN were upregulated by the effect of surface roughness and hydrophilicity, which were further enhanced by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	secreted phosphoprotein 1	Mus musculus	25-28
22941963-10	2013	The expression levels of OPN and OCN were upregulated by the effect of surface roughness and hydrophilicity, which were further enhanced by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	bone gamma-carboxyglutamate protein 2	Mus musculus	33-36
23180656-5	2013	Results show that specific inhibitors of Mitogen-Activated Protein Kinase Kinase (MEK) (PD98059) and phosphatidylinositol 3-kinase [PI3-K (LY294002)] markedly downregulated gene transcription and expression of BZLF1 and BMRF1 indicating that the MEK/ERK1/2 and PI3-K/Akt pathways are involved in the EBV spontaneous lytic cycle cascade.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	protein Zta	Human gammaherpesvirus 4	210-215
23180656-5	2013	Results show that specific inhibitors of Mitogen-Activated Protein Kinase Kinase (MEK) (PD98059) and phosphatidylinositol 3-kinase [PI3-K (LY294002)] markedly downregulated gene transcription and expression of BZLF1 and BMRF1 indicating that the MEK/ERK1/2 and PI3-K/Akt pathways are involved in the EBV spontaneous lytic cycle cascade.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	BMRF1	Human gammaherpesvirus 4	220-225
23208610-5	2013	CCN2-stimulated phosphorylation of Akt and GSK-3beta was sensitive to inhibition of PI3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	AKT serine/threonine kinase 1	Homo sapiens	35-38
23208610-5	2013	CCN2-stimulated phosphorylation of Akt and GSK-3beta was sensitive to inhibition of PI3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	glycogen synthase kinase 3 beta	Homo sapiens	43-52
23449446-6	2013	In this study, we investigated beta-catenin and NF-kappaB signaling through regulation of glycogen synthase kinase 3beta activity (GSK-3beta, which modulates beta-catenin and NF-kappaB signaling) using a specific inhibitor LiCl and a phosphatidylinositol 3-kinase (PI3K) inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	281-290	catenin beta 1	Homo sapiens	31-43
23212450-8	2013	Conversely, cell exposure to the PI3K inhibitor LY294002 increases HER2 phosphorylation, suggesting the involvement of PI3K/AKT in HER2 regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-71
23212450-8	2013	Conversely, cell exposure to the PI3K inhibitor LY294002 increases HER2 phosphorylation, suggesting the involvement of PI3K/AKT in HER2 regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	124-127
23212450-8	2013	Conversely, cell exposure to the PI3K inhibitor LY294002 increases HER2 phosphorylation, suggesting the involvement of PI3K/AKT in HER2 regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	erb-b2 receptor tyrosine kinase 2	Homo sapiens	131-135
23879997-12	2013	When the AKT signaling was blocked by 10 micromol/L LY294002, the 0.001 and 0.01 micromol/L paclitaxel-induced early apoptosis rate in A375 cells was increased by 2.02- and 1.46-fold, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	9-12
23357479-4	2013	Furthermore, the neuroprotection of B3C was abolished by phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	57-86
23449446-6	2013	In this study, we investigated beta-catenin and NF-kappaB signaling through regulation of glycogen synthase kinase 3beta activity (GSK-3beta, which modulates beta-catenin and NF-kappaB signaling) using a specific inhibitor LiCl and a phosphatidylinositol 3-kinase (PI3K) inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	281-290	nuclear factor kappa B subunit 1	Homo sapiens	48-57
23449446-6	2013	In this study, we investigated beta-catenin and NF-kappaB signaling through regulation of glycogen synthase kinase 3beta activity (GSK-3beta, which modulates beta-catenin and NF-kappaB signaling) using a specific inhibitor LiCl and a phosphatidylinositol 3-kinase (PI3K) inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	281-290	glycogen synthase kinase 3 beta	Homo sapiens	90-120
23449446-6	2013	In this study, we investigated beta-catenin and NF-kappaB signaling through regulation of glycogen synthase kinase 3beta activity (GSK-3beta, which modulates beta-catenin and NF-kappaB signaling) using a specific inhibitor LiCl and a phosphatidylinositol 3-kinase (PI3K) inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	281-290	glycogen synthase kinase 3 beta	Homo sapiens	131-140
23174757-10	2013	Moreover, A779, LY294002 and AG490 attenuated Ang-(1-7)-inhibited TGF-beta1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	angiogenin	Rattus norvegicus	46-54
23426781-4	2013	In Saos-2 cells, overexpression of TWIST significantly decreased ET-1 mRNA and protein expression levels, cell survival against cisplatin and phosphorylation of Akt at serine 473 (ser473), which was abolished by the selective phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, or the selective ETAR inhibitor, BQ123.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	274-282	twist family bHLH transcription factor 1	Homo sapiens	35-40
23426781-4	2013	In Saos-2 cells, overexpression of TWIST significantly decreased ET-1 mRNA and protein expression levels, cell survival against cisplatin and phosphorylation of Akt at serine 473 (ser473), which was abolished by the selective phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, or the selective ETAR inhibitor, BQ123.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	274-282	endothelin 1	Homo sapiens	65-69
23426781-4	2013	In Saos-2 cells, overexpression of TWIST significantly decreased ET-1 mRNA and protein expression levels, cell survival against cisplatin and phosphorylation of Akt at serine 473 (ser473), which was abolished by the selective phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, or the selective ETAR inhibitor, BQ123.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	274-282	AKT serine/threonine kinase 1	Homo sapiens	161-164
23426781-6	2013	However, exogenous ET-1 only partially rescued cell survival against cisplatin-induced apoptosis in the cells in which TWIST had been knocked down in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	endothelin 1	Homo sapiens	19-23
23194750-6	2013	Analysis of phospho-Akt (ser 473) in lysates from rat arteries (by immunoblot) revealed that thiazolidinediones, LY294002 and 10-DEBC, at the same concentration and kinetics inhibiting vasoconstriction, produced a similar decrease of Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Rattus norvegicus	234-237
23429283-8	2013	Furthermore, PI3K inhibitor LY294002 and Erk1/2 inhibitor U0126 suppressed the induction of HO-1 and translocation of Nrf-2 by xyloketal B, whereas P38 inhibitor SB203580 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	heme oxygenase 1a	Danio rerio	92-96
23429283-8	2013	Furthermore, PI3K inhibitor LY294002 and Erk1/2 inhibitor U0126 suppressed the induction of HO-1 and translocation of Nrf-2 by xyloketal B, whereas P38 inhibitor SB203580 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	nfe2 like bZIP transcription factor 2a	Danio rerio	118-123
23219579-9	2013	The Dex-induced increment of neuron survival in the ischemic CA1 and cortex was diminished by the PI3K inhibitor LY294002 and the MEK inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	carbonic anhydrase 1	Rattus norvegicus	61-64
23219579-10	2013	The increasing expressions of p-Akt and p-ERK1/2 induced by Dex in the ischemic hemisphere were markedly inhibited by LY294002 (or wortmannin) and U0126 (or PD98059), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	AKT serine/threonine kinase 1	Rattus norvegicus	32-35
23442498-12	2013	LY294002 (PI3k/AKT inhibitor) inhibited AGEs-induced macrophage migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	15-18
23363008-7	2013	The employment of protein kinase inhibitors LY294002, SB203580, SP600125, and U0126 revealed that PI3K/Akt signaling pathway interplayed with MAPK signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	103-106
23363008-7	2013	The employment of protein kinase inhibitors LY294002, SB203580, SP600125, and U0126 revealed that PI3K/Akt signaling pathway interplayed with MAPK signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	mitogen-activated protein kinase 3	Homo sapiens	142-146
22821817-6	2013	RESULTS: In these cell lines, AR-V7 transcriptional activity was inhibited by LY294002, Wortmanin, and AKT inhibitor II.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	androgen receptor	Homo sapiens	30-32
23201927-7	2013	Conversely, blocking Akt activation with the PI3K inhibitor LY294002 effectively suppressed the protective effect of Sal B against ATO-induced cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	21-24
23174757-10	2013	Moreover, A779, LY294002 and AG490 attenuated Ang-(1-7)-inhibited TGF-beta1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	transforming growth factor, beta 1	Rattus norvegicus	66-75
23219871-8	2013	Moreover, the expression of phosphorylated Akt (p-Akt) protein in TAO cells was up-regulated by IGF-1, while a specific PI3K inhibitor (LY294002) or an antibody of IGF-1R blocked this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	AKT serine/threonine kinase 1	Homo sapiens	43-46
23219579-10	2013	The increasing expressions of p-Akt and p-ERK1/2 induced by Dex in the ischemic hemisphere were markedly inhibited by LY294002 (or wortmannin) and U0126 (or PD98059), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	mitogen activated protein kinase 3	Rattus norvegicus	42-48
23219579-11	2013	The up-regulation of p-GSK-3beta by Dex in the ischemic hemisphere was significantly decreased by both LY294002 (or wortmannin) and U0126 (or PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	glycogen synthase kinase 3 beta	Rattus norvegicus	23-32
23218741-8	2013	Administration of IL-29 blocking antibody, AG490 or LY294002 abolished IL-29-induced IL-4 release from P815 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	interleukin 4	Mus musculus	85-89
23219871-8	2013	Moreover, the expression of phosphorylated Akt (p-Akt) protein in TAO cells was up-regulated by IGF-1, while a specific PI3K inhibitor (LY294002) or an antibody of IGF-1R blocked this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	AKT serine/threonine kinase 1	Homo sapiens	50-53
23233163-8	2013	In vitro, VEGF expression, which was induced by HGF, was inhibited by anti-HGF antibody, NK4 and by kinase inhibitors (PI3K, LY294002; MAPK, PD98059; and STAT3, Stattic).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	vascular endothelial growth factor A	Mus musculus	10-14
23146690-6	2013	The inhibition of phosphoinositide 3-kinase using Ly294002 augmented a decrease in the p21 level induced by their combination, but it showed no significant effects on expression of Sp1 and cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	H3 histone pseudogene 16	Homo sapiens	87-90
23208603-4	2013	When the TLR2 downstream signaling molecule phosphatidylinositol 3-kinase (PI3K) was blocked using wortmannin or LY294002, the difference in disruption of the intestinal epithelium and bacterial translocation was no longer observed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	toll-like receptor 2	Mus musculus	9-13
23254481-7	2013	Markedly, pharmacological inhibition studies             showed that pretreatment with LY294002 (a PI3K/PKB inhibitor) or GF109203X (a             pan-PKC inhibitor) suppressed the PDGF-D-induced expression of COX-2 protein and             mRNA, while pretreatment with PD98059 (an ERK-1/2 inhibitor) or PP1 (an Src inhibitor)             had no effect on it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	platelet derived growth factor D	Rattus norvegicus	181-187
23254481-7	2013	Markedly, pharmacological inhibition studies             showed that pretreatment with LY294002 (a PI3K/PKB inhibitor) or GF109203X (a             pan-PKC inhibitor) suppressed the PDGF-D-induced expression of COX-2 protein and             mRNA, while pretreatment with PD98059 (an ERK-1/2 inhibitor) or PP1 (an Src inhibitor)             had no effect on it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	210-215
23254481-7	2013	Markedly, pharmacological inhibition studies             showed that pretreatment with LY294002 (a PI3K/PKB inhibitor) or GF109203X (a             pan-PKC inhibitor) suppressed the PDGF-D-induced expression of COX-2 protein and             mRNA, while pretreatment with PD98059 (an ERK-1/2 inhibitor) or PP1 (an Src inhibitor)             had no effect on it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	mitogen activated protein kinase 3	Rattus norvegicus	282-289
23118130-7	2013	Hcy-increased CTLA4 endocytosis and secretion of inflammatory cytokines in T cells were blocked by CTLA4-IgG and the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	14-19
23261760-5	2013	TGF-beta1 enhanced glioma-induced angiogenesis, which was inhibited by JNK inhibitor SP600125 but not p38 MAPK inhibitor SB202190, ERK inhibitor PD98059, or PI3K inhibitor LY294002, indicating the important role of TGF-beta1 and JNK pathways in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	mitogen-activated protein kinase 8b	Danio rerio	71-74
23233163-10	2013	Real-time RT-PCR demonstrated that HGF-induced HIF-1alpha mRNA expression was not inhibited by LY294002 and PD98059, but was inhibited by Stattic.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	hepatocyte growth factor	Mus musculus	35-38
23254481-7	2013	Markedly, pharmacological inhibition studies             showed that pretreatment with LY294002 (a PI3K/PKB inhibitor) or GF109203X (a             pan-PKC inhibitor) suppressed the PDGF-D-induced expression of COX-2 protein and             mRNA, while pretreatment with PD98059 (an ERK-1/2 inhibitor) or PP1 (an Src inhibitor)             had no effect on it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	neuropeptide Y receptor Y4	Rattus norvegicus	304-307
23254481-7	2013	Markedly, pharmacological inhibition studies             showed that pretreatment with LY294002 (a PI3K/PKB inhibitor) or GF109203X (a             pan-PKC inhibitor) suppressed the PDGF-D-induced expression of COX-2 protein and             mRNA, while pretreatment with PD98059 (an ERK-1/2 inhibitor) or PP1 (an Src inhibitor)             had no effect on it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	312-315
23255002-7	2013	The PI3K inhibitor LY294002 also suppressed rapamycin-induced phosphorylation of Akt and combined treatment showed synergistic growth inhibition of MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	81-84
23233163-10	2013	Real-time RT-PCR demonstrated that HGF-induced HIF-1alpha mRNA expression was not inhibited by LY294002 and PD98059, but was inhibited by Stattic.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	hypoxia inducible factor 1, alpha subunit	Mus musculus	47-57
22887215-8	2013	Notably, disruption of the PI3K/Akt pathway by LY294002, a PI3K/Akt inhibitor potentiated apoptosis in A549 cells by BAI at a subcytotoxic concentration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	32-35
22926956-6	2013	Notably, the activation of CB peptide-induced osteogenic differentiation was completely blocked to the basal level by the specific inhibitors for ERK1/2 (U0126) and Akt (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Homo sapiens	165-168
22887215-8	2013	Notably, disruption of the PI3K/Akt pathway by LY294002, a PI3K/Akt inhibitor potentiated apoptosis in A549 cells by BAI at a subcytotoxic concentration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	64-67
22930444-8	2013	Administration of the PI3K pharmacological inhibitor LY294002 abrogated this effect by regulating FOXO3a and p27(kip1) expression and subcellular localization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	forkhead box O3	Rattus norvegicus	98-104
22930444-8	2013	Administration of the PI3K pharmacological inhibitor LY294002 abrogated this effect by regulating FOXO3a and p27(kip1) expression and subcellular localization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	109-112
22930444-8	2013	Administration of the PI3K pharmacological inhibitor LY294002 abrogated this effect by regulating FOXO3a and p27(kip1) expression and subcellular localization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	113-117
23192871-9	2013	Inhibition of Akt activity with LY294002 reduced the G(1) and M phase differences observed in cells infected with wild-type and ORF12 mutant viruses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	14-17
22998445-10	2013	PI3K inhibitor LY294002 (30 mg/kg) attenuated in vivo stretch-induced COX-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	prostaglandin-endoperoxide synthase 2	Mus musculus	70-75
22998445-11	2013	LY294002 or RNA-interference also attenuated (HUC) stretch-induced COX-2 expression in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	67-72
22998445-12	2013	Furthermore, the results also show that LY294002 inhibits stretch-induced protein kinase C (PKCzeta) activation previously identified upstream of stretch-induced COX-2 expression in HUCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	prostaglandin-endoperoxide synthase 2	Mus musculus	162-167
22674052-5	2013	Besides, expression of phosphorylated-AKT and phosphorylated-ERK1/2 in fluoxetine-treated NSCs was effectively blocked (P&lt;0.05) by both PI3-K inhibitor (LY294002) and MEK inhibitor (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	AKT serine/threonine kinase 1	Rattus norvegicus	38-41
22674052-5	2013	Besides, expression of phosphorylated-AKT and phosphorylated-ERK1/2 in fluoxetine-treated NSCs was effectively blocked (P&lt;0.05) by both PI3-K inhibitor (LY294002) and MEK inhibitor (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	mitogen activated protein kinase 3	Rattus norvegicus	61-67
23392708-7	2013	Furthermore, Western blotting revealed that LY294002 combined with gemcitabine reduced the protein levels of p-Akt and MRP, which contributed to the inhibition of proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	111-114
23392708-7	2013	Furthermore, Western blotting revealed that LY294002 combined with gemcitabine reduced the protein levels of p-Akt and MRP, which contributed to the inhibition of proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	ATP binding cassette subfamily C member 1	Homo sapiens	119-122
23340048-4	2013	The GDNF-induced neurite outgrowth and GAL-1 upregulation were attenuated by anti-GDNF family receptor (RET) antibody and phosphatidyl inositol-3"-phosphate-kinase (PI3K) inhibitor LY294002, suggesting that the neurite-outgrowth promoting activity of GDNF may be attributable, at least partially, to the upregulation of GAL-1 through RET-PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	glial cell derived neurotrophic factor	Rattus norvegicus	4-8
23340048-4	2013	The GDNF-induced neurite outgrowth and GAL-1 upregulation were attenuated by anti-GDNF family receptor (RET) antibody and phosphatidyl inositol-3"-phosphate-kinase (PI3K) inhibitor LY294002, suggesting that the neurite-outgrowth promoting activity of GDNF may be attributable, at least partially, to the upregulation of GAL-1 through RET-PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	glial cell derived neurotrophic factor	Rattus norvegicus	82-86
23340048-4	2013	The GDNF-induced neurite outgrowth and GAL-1 upregulation were attenuated by anti-GDNF family receptor (RET) antibody and phosphatidyl inositol-3"-phosphate-kinase (PI3K) inhibitor LY294002, suggesting that the neurite-outgrowth promoting activity of GDNF may be attributable, at least partially, to the upregulation of GAL-1 through RET-PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	ret proto-oncogene	Rattus norvegicus	104-107
23165320-6	2013	Overexpression of AQP3 induced by hEGF was inhibited by a PI3K/AKT inhibitor, LY294002, but the ERK inhibitor U0126 had a minor effect on the hEGF-induced AQP3 upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	aquaporin 3 (Gill blood group)	Homo sapiens	18-22
23165320-6	2013	Overexpression of AQP3 induced by hEGF was inhibited by a PI3K/AKT inhibitor, LY294002, but the ERK inhibitor U0126 had a minor effect on the hEGF-induced AQP3 upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	epidermal growth factor	Homo sapiens	34-38
23229346-10	2013	Additionally, treatment             with the PI3K inhibitor LY294002 dramatically inhibited activation of NF-kappaB in             HER2-overexpressing breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	nuclear factor kappa B subunit 1	Homo sapiens	106-115
23229346-10	2013	Additionally, treatment             with the PI3K inhibitor LY294002 dramatically inhibited activation of NF-kappaB in             HER2-overexpressing breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	131-135
23340048-4	2013	The GDNF-induced neurite outgrowth and GAL-1 upregulation were attenuated by anti-GDNF family receptor (RET) antibody and phosphatidyl inositol-3"-phosphate-kinase (PI3K) inhibitor LY294002, suggesting that the neurite-outgrowth promoting activity of GDNF may be attributable, at least partially, to the upregulation of GAL-1 through RET-PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	122-163
23229346-11	2013	Moreover, LY294002 inhibited phosphorylation             of Akt and IkappaB-alpha in SKBR3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	60-63
23229346-11	2013	Moreover, LY294002 inhibited phosphorylation             of Akt and IkappaB-alpha in SKBR3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	NFKB inhibitor alpha	Homo sapiens	68-81
23340048-4	2013	The GDNF-induced neurite outgrowth and GAL-1 upregulation were attenuated by anti-GDNF family receptor (RET) antibody and phosphatidyl inositol-3"-phosphate-kinase (PI3K) inhibitor LY294002, suggesting that the neurite-outgrowth promoting activity of GDNF may be attributable, at least partially, to the upregulation of GAL-1 through RET-PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	glial cell derived neurotrophic factor	Rattus norvegicus	82-86
23710748-8	2013	(3) The expression of Akt, GSK-3beta and FOXO3a were significantly upregulated in I/R + DPQ group compared to I/R group (P &lt; 0.05) which were significantly attenuated in I/R + DPQ + LY294002 group compared to I/R + DPQ group (all P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
23229870-9	2013	The inhibition of p38 and Akt kinases with SB203580 and LY294002 further             increased resveratrol-induced MMP-9 as well as cell migration in the HT1080 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	mitogen-activated protein kinase 14	Homo sapiens	18-21
23229870-9	2013	The inhibition of p38 and Akt kinases with SB203580 and LY294002 further             increased resveratrol-induced MMP-9 as well as cell migration in the HT1080 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	26-29
23229870-9	2013	The inhibition of p38 and Akt kinases with SB203580 and LY294002 further             increased resveratrol-induced MMP-9 as well as cell migration in the HT1080 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	matrix metallopeptidase 9	Homo sapiens	115-120
23469688-6	2013	Indeed, the specific inhibitors (LY294002 and U0126) of PI3K/PDK1/Akt and ERK showed similar anti-cancer properties to 8-TQ.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	pyruvate dehydrogenase kinase 1	Homo sapiens	61-65
23469688-6	2013	Indeed, the specific inhibitors (LY294002 and U0126) of PI3K/PDK1/Akt and ERK showed similar anti-cancer properties to 8-TQ.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Homo sapiens	66-69
23469688-6	2013	Indeed, the specific inhibitors (LY294002 and U0126) of PI3K/PDK1/Akt and ERK showed similar anti-cancer properties to 8-TQ.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	mitogen-activated protein kinase 1	Homo sapiens	74-77
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	forkhead box O3	Mus musculus	94-100
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	forkhead box O3	Mus musculus	94-100
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	chemokine (C-X-C motif) ligand 15	Mus musculus	192-196
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	thymoma viral proto-oncogene 1	Mus musculus	220-223
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	epidermal growth factor receptor	Mus musculus	225-229
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	forkhead box O3	Mus musculus	94-100
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	forkhead box O3	Mus musculus	94-100
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	epidermal growth factor receptor	Mus musculus	225-229
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	thymoma viral proto-oncogene 1	Mus musculus	220-223
23233127-4	2013	Enhanced proliferation in             integrin alpha3-silenced cells is mediated by upregulation and nuclear localization             of cyclin-dependent kinases, and these effects require the activation of Akt and             ERK as evidenced by treatment with LY294002 and PD98059, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	262-270	integrin subunit alpha 3	Homo sapiens	38-53
23233127-4	2013	Enhanced proliferation in             integrin alpha3-silenced cells is mediated by upregulation and nuclear localization             of cyclin-dependent kinases, and these effects require the activation of Akt and             ERK as evidenced by treatment with LY294002 and PD98059, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	262-270	AKT serine/threonine kinase 1	Homo sapiens	207-210
23233127-4	2013	Enhanced proliferation in             integrin alpha3-silenced cells is mediated by upregulation and nuclear localization             of cyclin-dependent kinases, and these effects require the activation of Akt and             ERK as evidenced by treatment with LY294002 and PD98059, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	262-270	mitogen-activated protein kinase 1	Homo sapiens	227-230
23420812-7	2013	Exogenous ET-1 restored cell invasion and MMP-2 expression levels in MG-63 cells, in which AEG-1 had been knocked down, in the presence of LY294002, but not in the presence of BQ123.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	endothelin 1	Homo sapiens	10-14
23420812-7	2013	Exogenous ET-1 restored cell invasion and MMP-2 expression levels in MG-63 cells, in which AEG-1 had been knocked down, in the presence of LY294002, but not in the presence of BQ123.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	metadherin	Homo sapiens	91-96
23420812-8	2013	However, exogenous ET-1 only partially rescued cell survival against cisplatin-induced apoptosis in the presence of LY294002, in cells in which AEG-1 had been knocked down.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	endothelin 1	Homo sapiens	19-23
22457005-9	2013	Furthermore, poly (I:C)-induced caspase 3 cleavage in SGECs was also inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	caspase 3	Homo sapiens	32-41
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	forkhead box O3	Mus musculus	10-16
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	epidermal growth factor receptor	Mus musculus	80-84
23650795-11	2013	These results suggested an elimination of the acupuncture effect after blocking the PI 3 K/Akt signaling pathway by lateral ventricular injection of LY 294002 in epilepsy rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-158	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
23073341-3	2013	IGF-I and b-insulin induced testosterone and 17beta-estradiol production in carp ovarian theca and granulosa cells in short-term coincubation and this induction was significantly inhibited by Wortmannin and LY294002, two mechanistically different specific inhibitors of PI3 kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	insulin like growth factor 1	Homo sapiens	0-5
22716951-6	2013	The levels of phospho-Akt and phospho-extracellular signal-related kinase (ERK) were reduced in cells treated with maslinic acid, and the phosphoinositide 3-kinase inhibitor LY294002 and the mitogen-activated protein kinase kinase inhibitor PD98059 reduced HIF-1alpha levels and VEGF secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	AKT serine/threonine kinase 1	Homo sapiens	22-25
22716951-6	2013	The levels of phospho-Akt and phospho-extracellular signal-related kinase (ERK) were reduced in cells treated with maslinic acid, and the phosphoinositide 3-kinase inhibitor LY294002 and the mitogen-activated protein kinase kinase inhibitor PD98059 reduced HIF-1alpha levels and VEGF secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	mitogen-activated protein kinase 1	Homo sapiens	30-73
22716951-6	2013	The levels of phospho-Akt and phospho-extracellular signal-related kinase (ERK) were reduced in cells treated with maslinic acid, and the phosphoinositide 3-kinase inhibitor LY294002 and the mitogen-activated protein kinase kinase inhibitor PD98059 reduced HIF-1alpha levels and VEGF secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	mitogen-activated protein kinase 1	Homo sapiens	75-78
22716951-6	2013	The levels of phospho-Akt and phospho-extracellular signal-related kinase (ERK) were reduced in cells treated with maslinic acid, and the phosphoinositide 3-kinase inhibitor LY294002 and the mitogen-activated protein kinase kinase inhibitor PD98059 reduced HIF-1alpha levels and VEGF secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	hypoxia inducible factor 1 subunit alpha	Homo sapiens	257-267
22716951-6	2013	The levels of phospho-Akt and phospho-extracellular signal-related kinase (ERK) were reduced in cells treated with maslinic acid, and the phosphoinositide 3-kinase inhibitor LY294002 and the mitogen-activated protein kinase kinase inhibitor PD98059 reduced HIF-1alpha levels and VEGF secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	vascular endothelial growth factor A	Homo sapiens	279-283
23343403-14	2013	CCN4-mediated IL-6 production was attenuated by PI3K inhibitor (LY294002 and Wortmannin), Akt inhibitor (Akti), and NF-kappaB inhibitor (PDTC and TPCK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	cellular communication network factor 4	Homo sapiens	0-4
23343403-14	2013	CCN4-mediated IL-6 production was attenuated by PI3K inhibitor (LY294002 and Wortmannin), Akt inhibitor (Akti), and NF-kappaB inhibitor (PDTC and TPCK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	interleukin 6	Homo sapiens	14-18
23069715-7	2013	The inductions were abolished by the addition of phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	49-78
23246833-6	2013	Treatment with TO-901317, pertussis toxin, PP2, and LY294002 resulted not only in attenuated transcription of TNF-alpha induced by 27OHChol and 7alphaOHChol, but also secretion of TNF-alpha enhanced by 27OHChol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	tumor necrosis factor	Homo sapiens	110-119
23246833-6	2013	Treatment with TO-901317, pertussis toxin, PP2, and LY294002 resulted not only in attenuated transcription of TNF-alpha induced by 27OHChol and 7alphaOHChol, but also secretion of TNF-alpha enhanced by 27OHChol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	tumor necrosis factor	Homo sapiens	180-189
23069760-6	2013	The phosphoinositide 3-kinase (PI3K)-specific inhibitor LY294002 was used to elucidate whether the PI3K/Akt signaling pathway was activated by 17beta-estradiol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	4-29
23069760-6	2013	The phosphoinositide 3-kinase (PI3K)-specific inhibitor LY294002 was used to elucidate whether the PI3K/Akt signaling pathway was activated by 17beta-estradiol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Rattus norvegicus	104-107
23069760-11	2013	Moreover, the inhibition of Akt activation by LY294002 increased retinal neuronal apoptosis, demonstrating that the PI3K/Akt signaling pathway is involved.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
23069760-11	2013	Moreover, the inhibition of Akt activation by LY294002 increased retinal neuronal apoptosis, demonstrating that the PI3K/Akt signaling pathway is involved.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Rattus norvegicus	121-124
24009857-7	2013	Abrogation or significant attenuation of nystatin-induced expression of MIP-1alpha and MIP-1beta was observed by treatment with Akt inhibitor IV, LY294002, and SP6001250.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	C-C motif chemokine ligand 3	Homo sapiens	72-82
23710442-8	2013	The PI3K inhibitor LY294002 blocked p-Akt and p-GSK3 beta expressions in podocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	38-41
23710442-8	2013	The PI3K inhibitor LY294002 blocked p-Akt and p-GSK3 beta expressions in podocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	glycogen synthase kinase 3 beta	Homo sapiens	48-57
24009857-7	2013	Abrogation or significant attenuation of nystatin-induced expression of MIP-1alpha and MIP-1beta was observed by treatment with Akt inhibitor IV, LY294002, and SP6001250.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	C-C motif chemokine ligand 4	Homo sapiens	87-96
24335179-8	2013	On the other hand, TPA-induced VEGF and FN expression was suppressed by LY294002, a PI-3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	vascular endothelial growth factor A	Homo sapiens	31-35
23351384-7	2013	The protective effect of Hsp90beta against apoptosis was negated by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	heat shock protein 90 alpha family class B member 1	Homo sapiens	25-34
23351384-7	2013	The protective effect of Hsp90beta against apoptosis was negated by LY294002, an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	81-84
23420486-3	2013	The activation of Akt in ovarian cancer cells, as marked by its phosphorylation on Ser473, was not modified by cytostatic concentrations of mifepristone, but it was blocked upon treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	AKT serine/threonine kinase 1	Homo sapiens	18-21
23420486-4	2013	The combination mifepristone/LY294002, but not the individual drugs, killed ovarian cancer cells via apoptosis, as attested by genomic DNA fragmentation and cleavage of caspase-3, and the concomitant down-regulation of anti-apoptotic proteins Bcl-2 and XIAP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	caspase 3	Homo sapiens	169-178
23420486-4	2013	The combination mifepristone/LY294002, but not the individual drugs, killed ovarian cancer cells via apoptosis, as attested by genomic DNA fragmentation and cleavage of caspase-3, and the concomitant down-regulation of anti-apoptotic proteins Bcl-2 and XIAP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	BCL2 apoptosis regulator	Homo sapiens	243-248
23420486-4	2013	The combination mifepristone/LY294002, but not the individual drugs, killed ovarian cancer cells via apoptosis, as attested by genomic DNA fragmentation and cleavage of caspase-3, and the concomitant down-regulation of anti-apoptotic proteins Bcl-2 and XIAP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	X-linked inhibitor of apoptosis	Homo sapiens	253-257
23635649-8	2013	Both LY 294002 and wortmannin inhibited phospho-Akt, phospho-mTOR, phospho-GSK 3beta and HIF-1alpha expression after isoflurane exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-14	AKT serine/threonine kinase 1	Rattus norvegicus	48-51
23635649-8	2013	Both LY 294002 and wortmannin inhibited phospho-Akt, phospho-mTOR, phospho-GSK 3beta and HIF-1alpha expression after isoflurane exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-14	mechanistic target of rapamycin kinase	Rattus norvegicus	61-65
23635649-8	2013	Both LY 294002 and wortmannin inhibited phospho-Akt, phospho-mTOR, phospho-GSK 3beta and HIF-1alpha expression after isoflurane exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-14	glycogen synthase kinase 3 beta	Rattus norvegicus	75-84
23635649-8	2013	Both LY 294002 and wortmannin inhibited phospho-Akt, phospho-mTOR, phospho-GSK 3beta and HIF-1alpha expression after isoflurane exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-14	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	89-99
24335166-12	2013	AZA"s effects were significantly reduced by Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	thymoma viral proto-oncogene 1	Mus musculus	44-47
24335179-8	2013	On the other hand, TPA-induced VEGF and FN expression was suppressed by LY294002, a PI-3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	fibronectin 1	Homo sapiens	40-42
24592124-4	2013	CONCLUSIONS: Akt protein phosphorylation of trastuzumab drug-resistance cells is activated; LY294002, a PI3K/Akt inhibitor, can obviously inhibit Akt protein phosphorylation of trastuzumab drug-resistance cells and there is a clear association between the PI3K/Akt signal transduction pathway and trastuzumab resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	13-16
22678424-8	2013	TGFbeta3 caused a significant increase in pAKT(ser473) in PC3 cells and PI3-kinase inhibitor LY294002 blocked TGFbeta3 induced migration, invasion and phosphorylation of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	transforming growth factor beta 3	Homo sapiens	0-8
22678424-8	2013	TGFbeta3 caused a significant increase in pAKT(ser473) in PC3 cells and PI3-kinase inhibitor LY294002 blocked TGFbeta3 induced migration, invasion and phosphorylation of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	transforming growth factor beta 3	Homo sapiens	110-118
24592124-4	2013	CONCLUSIONS: Akt protein phosphorylation of trastuzumab drug-resistance cells is activated; LY294002, a PI3K/Akt inhibitor, can obviously inhibit Akt protein phosphorylation of trastuzumab drug-resistance cells and there is a clear association between the PI3K/Akt signal transduction pathway and trastuzumab resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	109-112
22954322-7	2013	Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	interleukin 6	Homo sapiens	43-47
24592124-4	2013	CONCLUSIONS: Akt protein phosphorylation of trastuzumab drug-resistance cells is activated; LY294002, a PI3K/Akt inhibitor, can obviously inhibit Akt protein phosphorylation of trastuzumab drug-resistance cells and there is a clear association between the PI3K/Akt signal transduction pathway and trastuzumab resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	109-112
22954322-7	2013	Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	C-X-C motif chemokine ligand 10	Homo sapiens	49-54
24592124-4	2013	CONCLUSIONS: Akt protein phosphorylation of trastuzumab drug-resistance cells is activated; LY294002, a PI3K/Akt inhibitor, can obviously inhibit Akt protein phosphorylation of trastuzumab drug-resistance cells and there is a clear association between the PI3K/Akt signal transduction pathway and trastuzumab resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	109-112
22954322-7	2013	Whereas the poly(I:C)-induced secretion of IL-6, IP-10, and RANTES was inhibited by both IKK-2 inhibitor and LY294002, that of IL-8 was blocked only by IKK-2 inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	C-C motif chemokine ligand 5	Homo sapiens	60-66
23992306-5	2013	In addition, the levels of phospho-Akt and phospho- NF-kappaB in BxPC-3 and Panc-1 cells were reduced by both resveratrol and LY294002 (a PI3-K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	AKT serine/threonine kinase 1	Homo sapiens	35-38
24094245-4	2013	The relationship between PI3K/Akt pathway and Nrf2/HO-1 axis was demonstrated by the finding that pretreatment with PI3K inhibitors (wortmannin, LY294002) attenuated the upregulation of Nrf2 expression induced by HBCDs exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	AKT serine/threonine kinase 1	Homo sapiens	30-33
23992306-5	2013	In addition, the levels of phospho-Akt and phospho- NF-kappaB in BxPC-3 and Panc-1 cells were reduced by both resveratrol and LY294002 (a PI3-K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	nuclear factor kappa B subunit 1	Homo sapiens	52-61
23337518-7	2013	Importantly, addition of phosphoinositide-3 kinase (PI3K) inhibitor LY294002 led to a marked inhibition of Ang II induced SMC specific markers, phosphoAkt and NF-kappaB p50 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	107-113
23337518-7	2013	Importantly, addition of phosphoinositide-3 kinase (PI3K) inhibitor LY294002 led to a marked inhibition of Ang II induced SMC specific markers, phosphoAkt and NF-kappaB p50 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	159-172
24094245-4	2013	The relationship between PI3K/Akt pathway and Nrf2/HO-1 axis was demonstrated by the finding that pretreatment with PI3K inhibitors (wortmannin, LY294002) attenuated the upregulation of Nrf2 expression induced by HBCDs exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
24094245-4	2013	The relationship between PI3K/Akt pathway and Nrf2/HO-1 axis was demonstrated by the finding that pretreatment with PI3K inhibitors (wortmannin, LY294002) attenuated the upregulation of Nrf2 expression induced by HBCDs exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	heme oxygenase 1	Homo sapiens	51-55
24094245-4	2013	The relationship between PI3K/Akt pathway and Nrf2/HO-1 axis was demonstrated by the finding that pretreatment with PI3K inhibitors (wortmannin, LY294002) attenuated the upregulation of Nrf2 expression induced by HBCDs exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	NFE2 like bZIP transcription factor 2	Homo sapiens	186-190
23043959-13	2013	Overexpression of DN-Akt or constitutively active GSK-3beta or pretreatment of LY294002 inhibited rhHsp70-induced iHsp70 up-regulation, which was similar to the mechanism of HS-mediated induction of Hsp70.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	heat shock protein family A (Hsp70) member 4	Homo sapiens	100-105
23762109-5	2013	Western blot analysis findings further indicated that TSD medicated serum upregulated p-Akt and p-eNOS expressions, which were significantly inhibited by LY294002 or L-NAME and completely inhibited by both LY294002 and L-NAME; these results indicated that TSD medicated serum induced HUVECs VEGF expression via PI3K/Akt-eNOS signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Homo sapiens	88-91
23762109-5	2013	Western blot analysis findings further indicated that TSD medicated serum upregulated p-Akt and p-eNOS expressions, which were significantly inhibited by LY294002 or L-NAME and completely inhibited by both LY294002 and L-NAME; these results indicated that TSD medicated serum induced HUVECs VEGF expression via PI3K/Akt-eNOS signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	206-214	AKT serine/threonine kinase 1	Homo sapiens	88-91
23762109-5	2013	Western blot analysis findings further indicated that TSD medicated serum upregulated p-Akt and p-eNOS expressions, which were significantly inhibited by LY294002 or L-NAME and completely inhibited by both LY294002 and L-NAME; these results indicated that TSD medicated serum induced HUVECs VEGF expression via PI3K/Akt-eNOS signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	206-214	vascular endothelial growth factor A	Homo sapiens	291-295
23762109-5	2013	Western blot analysis findings further indicated that TSD medicated serum upregulated p-Akt and p-eNOS expressions, which were significantly inhibited by LY294002 or L-NAME and completely inhibited by both LY294002 and L-NAME; these results indicated that TSD medicated serum induced HUVECs VEGF expression via PI3K/Akt-eNOS signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	206-214	AKT serine/threonine kinase 1	Homo sapiens	316-319
23781261-6	2013	The results showed that XXMD improved neurological function, decreased cerebral infarct area and neuronal damage, and attenuated cellular apoptosis in neurovascular unit, while these effects were abolished by inhibition of PI3K/Akt with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	237-245	AKT serine/threonine kinase 1	Rattus norvegicus	228-231
23781261-7	2013	We also found that XXMD upregulated p-PDKl, p-Akt, and p-GSK3 beta expression levels, which were partly reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Rattus norvegicus	46-49
23781261-8	2013	In addition, the increases of p-PTEN and p-c-Raf expression levels on which LY294002 had no effect were also observed in response to XXMD treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	43-48
23278900-5	2013	The treatment with LY294002, SP600125 or U0126 hindered the tension-induced TGFbeta2 upregulation, although the increase in NGF was regulated only by SP600125 or U0126, indicating the involvement of three signalling kinase pathways in the upregulation of TGFbeta2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	transforming growth factor beta 2	Homo sapiens	76-84
22902327-7	2013	Consistent with Akt inhibition as the basis of piperine"s action on HUVECs, inhibition of the phosphoinositide-3 kinase/Akt signaling pathway with LY-294002 also inhibited HUVEC proliferation and collagen-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-156	AKT serine/threonine kinase 1	Homo sapiens	120-123
24455422-7	2013	We then showed that the neuroprotective effect of CE was blocked by adding the AKT inhibitor, Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	AKT serine/threonine kinase 1	Rattus norvegicus	79-82
23063593-7	2013	Additionally, HER effectively inhibited the phosphorylation of Akt and the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 increased the inhibition effect of HER on Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	75-104
23063593-7	2013	Additionally, HER effectively inhibited the phosphorylation of Akt and the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 increased the inhibition effect of HER on Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Homo sapiens	173-176
22975582-6	2013	More importantly, PI3K/AKT signaling pathway inhibitor, LY294002, also reduced tumor cell proliferation, which is similar to the result with or without sCLU siRNA treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	23-26
23603894-4	2013	We further demonstrated that the blockage of radiation-induced activation of the PI3K/AKT pathway and its downstream regulator NF-kappaB by either curcumin or specific PI3/AKT inhibitors (LY294002 for PI3K or SH-5 for AKT) enhance apoptosis in three human Burkitt"s lymphoma cell lines (Namalwa, Ramos, and Raji) that were treated with ionizing radiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	AKT serine/threonine kinase 1	Homo sapiens	86-89
23603894-4	2013	We further demonstrated that the blockage of radiation-induced activation of the PI3K/AKT pathway and its downstream regulator NF-kappaB by either curcumin or specific PI3/AKT inhibitors (LY294002 for PI3K or SH-5 for AKT) enhance apoptosis in three human Burkitt"s lymphoma cell lines (Namalwa, Ramos, and Raji) that were treated with ionizing radiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	nuclear factor kappa B subunit 1	Homo sapiens	127-136
23603894-4	2013	We further demonstrated that the blockage of radiation-induced activation of the PI3K/AKT pathway and its downstream regulator NF-kappaB by either curcumin or specific PI3/AKT inhibitors (LY294002 for PI3K or SH-5 for AKT) enhance apoptosis in three human Burkitt"s lymphoma cell lines (Namalwa, Ramos, and Raji) that were treated with ionizing radiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	AKT serine/threonine kinase 1	Homo sapiens	172-175
23603894-4	2013	We further demonstrated that the blockage of radiation-induced activation of the PI3K/AKT pathway and its downstream regulator NF-kappaB by either curcumin or specific PI3/AKT inhibitors (LY294002 for PI3K or SH-5 for AKT) enhance apoptosis in three human Burkitt"s lymphoma cell lines (Namalwa, Ramos, and Raji) that were treated with ionizing radiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	AKT serine/threonine kinase 1	Homo sapiens	172-175
23001846-8	2013	HBx-induced increase in the autophagic level was increased by mTOR inhibitor rapamycin and was blocked by treatment with the PI3K-Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	X protein	Hepatitis B virus	0-3
23818741-5	2013	PI3K/AKT inhibitor LY294002 reversed the effect of tryptase on IL-6 production, whereas inhibitors specific for p38, JNK, and ERK1/2 abolished the effect of tryptase on TNF- alpha production, suggesting that different signaling pathways are involved.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	interleukin 6	Homo sapiens	63-67
23001846-8	2013	HBx-induced increase in the autophagic level was increased by mTOR inhibitor rapamycin and was blocked by treatment with the PI3K-Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	AKT serine/threonine kinase 1	Homo sapiens	130-133
23001847-7	2013	HIF-1alpha could be blocked by phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1alpha activation was regulated by the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10
23124851-0	2013	Chronic treatment with LY294002, an inhibitor of phosphatidylinositol 3-kinase, attenuates ischemia/reperfusion-induced cardiac dysfunction in normotensive and hypertensive diabetic animals.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	49-78
23001847-7	2013	HIF-1alpha could be blocked by phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1alpha activation was regulated by the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	105-115
23001847-7	2013	HIF-1alpha could be blocked by phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1alpha activation was regulated by the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Rattus norvegicus	153-156
23401656-10	2013	VEGF secretion was also diminished after phosphatidylinositol 3 kinase was inhibited by LY294002 for 48 h. Coapplication of the substances did not show an additive effect, suggesting that they use the same pathway in an autocrine-positive VEGF regulation loop.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	vascular endothelial growth factor A	Homo sapiens	0-4
22948038-11	2013	E2-induced Nrf2 activation was attenuated by the PI3K inhibitor LY294002 and the estrogen receptor antagonist ICI 182,780.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	NFE2 like bZIP transcription factor 2	Homo sapiens	11-15
23353163-5	2013	RESULTS: At the optimal concentration of 0.3 ng/ml, MCP-3 treatment for 24 h caused significantly increased ICAM-1, VCAM-1, and TF expressions with lowered expression of TFPI in HUVECs (P&lt;0.05), and such effects were significantly inhibited by the application of MCP-3 antibody, PI3K inhibitor, or LY-294002 (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	301-310	C-C motif chemokine ligand 7	Homo sapiens	52-57
23147408-9	2013	EGF itself also protected the cells from MG-induced apoptosis and induced phosphorylation of Akt, which was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
23063465-9	2013	Treatment of both U0126 (an inhibitor of MEK) and LY294002 (an inhibitor of PI3 K), hampered the neuronal differentiation induced by Rg1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	protein phosphatase 1, regulatory subunit 3A	Mus musculus	133-136
23142153-8	2013	In addition, although RA activates both the AKT and ERK phosphorylation signaling pathways, only pretreatment with LY294002, an inhibitor of PI3-kinase in the AKT pathway, removed the protective effect of RA from the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	AKT serine/threonine kinase 1	Homo sapiens	44-47
23142153-8	2013	In addition, although RA activates both the AKT and ERK phosphorylation signaling pathways, only pretreatment with LY294002, an inhibitor of PI3-kinase in the AKT pathway, removed the protective effect of RA from the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	mitogen-activated protein kinase 1	Homo sapiens	52-55
23142153-8	2013	In addition, although RA activates both the AKT and ERK phosphorylation signaling pathways, only pretreatment with LY294002, an inhibitor of PI3-kinase in the AKT pathway, removed the protective effect of RA from the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	AKT serine/threonine kinase 1	Homo sapiens	159-162
22610785-9	2013	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, suppressed alpha-Syn-induced Abeta1-40 elevation, as well as Abeta1-42-induced alpha-Syn elevation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	synuclein alpha	Rattus norvegicus	72-81
23909734-6	2013	Moreover LY294002 not only downregulated the level of phospho-Akt but also enhanced the inhibition of Mcl-1 expression when combined with Triticuside A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	62-65
23132328-8	2013	Notably, the p-AKT inhibitor LY294002 attenuated the impact of Scriptaid, providing mechanistic evidence that Scriptaid functions partly by modulating the prosurvival AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	15-18
23132328-8	2013	Notably, the p-AKT inhibitor LY294002 attenuated the impact of Scriptaid, providing mechanistic evidence that Scriptaid functions partly by modulating the prosurvival AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	167-170
23909734-6	2013	Moreover LY294002 not only downregulated the level of phospho-Akt but also enhanced the inhibition of Mcl-1 expression when combined with Triticuside A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	102-107
24406042-5	2013	Inhibition of the PI3K-AKT pathway by LY294002, but not the MEK-ERK pathway by PD98509, reversed the above effects in these cells induced by Ran overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	RAN, member RAS oncogene family	Homo sapiens	141-144
24454979-7	2013	Furthermore, administration of LY294002, an inhibitor of PI3K, compromised the protective effect of CO and decreased the level of phospho-GSK3beta after I/R injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	glycogen synthase kinase 3 beta	Mus musculus	138-146
23590603-8	2013	It was then further demonstrated that the effects of rhNRG-1 could be blocked by the phosphoinositole-3-kinase inhibitor LY294002, indicating the involvement of the Akt process in mediating the process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	AKT serine/threonine kinase 1	Homo sapiens	165-168
23555802-7	2013	LY294002 blocked the increase in phospho-Akt evoked by curcumin and abolished the associated protective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
23255946-13	2013	The Akt inhibitor LY294002 caused a significant decrease in TNF-alpha-induced NF-kappaB activity and MMP-9 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	4-7
23255946-13	2013	The Akt inhibitor LY294002 caused a significant decrease in TNF-alpha-induced NF-kappaB activity and MMP-9 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	tumor necrosis factor	Homo sapiens	60-69
23255946-13	2013	The Akt inhibitor LY294002 caused a significant decrease in TNF-alpha-induced NF-kappaB activity and MMP-9 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	nuclear factor kappa B subunit 1	Homo sapiens	78-87
23255946-13	2013	The Akt inhibitor LY294002 caused a significant decrease in TNF-alpha-induced NF-kappaB activity and MMP-9 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	matrix metallopeptidase 9	Homo sapiens	101-106
23468877-10	2013	Fibroblast growth factor receptor (FGFR) kinase inhibitor PD173074, PI3K inhibitor LY294002, and MEK1/2 inhibitor PD98059 were used to dissect the molecular mechanism of FGF-2 induced AQP3 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	fibroblast growth factor 2	Homo sapiens	170-175
23536783-7	2013	Cholesterol accumulation was inhibited approximately 50% in wild-type and LDLR-/- mice treated with LY294002 or wortmannin, inhibitors of all classes of phosphoinositide 3-kinases (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	low density lipoprotein receptor	Mus musculus	74-78
23472139-6	2013	The AGEs-stimulated Akt activation was blocked by a PI3-kinase inhibitor LY 294002, Src inhibitor PP2, an antioxidant NAC, superoxide scavenger Tiron, or nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase inhibitor DPI, suggesting the involvement of Src and NAD(P)H oxidase in the activation of PI3-kinase-Akt pathway by AGEs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-82	thymoma viral proto-oncogene 1	Mus musculus	20-23
23468877-15	2013	The PI3K inhibitor LY294002 and MEK1/2 inhibitor PD98059 inhibited, but not fully blocked, FGF-2-induced AQP3 expression and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	fibroblast growth factor 2	Homo sapiens	91-96
23468877-15	2013	The PI3K inhibitor LY294002 and MEK1/2 inhibitor PD98059 inhibited, but not fully blocked, FGF-2-induced AQP3 expression and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	aquaporin 3 (Gill blood group)	Homo sapiens	105-109
23555904-11	2013	Similarly, CD107a expression significantly decreased following PMA-I stimulation with the addition of LY294002, PD98059 and Rottlerin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	lysosomal associated membrane protein 1	Homo sapiens	11-17
23472139-13	2013	AGEs treatment promoted the differentiation of 3T3-L1 preadipocytes and addition of AG1024, LY 294002 or Akt inhibitor attenuated the promoting effect of AGEs on adipogenesis, suggesting that IGF-1 receptor, PI3-Kinase and Akt are involved in the facilitation of adipogenesis by AGEs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-101	insulin-like growth factor 1	Mus musculus	192-197
23437382-7	2013	Further analysis showed that inhibition of PI3K/Akt pathway with specific inhibitor (LY294002) attenuated the promotive effects on cancer growth following interfering with klotho shRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Homo sapiens	48-51
23437382-7	2013	Further analysis showed that inhibition of PI3K/Akt pathway with specific inhibitor (LY294002) attenuated the promotive effects on cancer growth following interfering with klotho shRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	klotho	Homo sapiens	172-178
23143065-7	2013	A specific PI3K inhibitor, LY294002, attenuated the inhibition of nitrite production and iNOS expression produced by overexpressing a liver-specific Epac2 (LEpac2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	nitric oxide synthase 2	Homo sapiens	89-93
23301033-9	2013	LY294002, a specific inhibitor of PI3K, effectively impaired Tat"s promotion of vIL-6-induced tumorigenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	villin 1	Homo sapiens	80-83
23383347-6	2013	The involvement of Akt and NF-kappaB signaling pathways in the EGF-induced IL-1beta gene expression was confirmed by knockdown of RelA and Akt in cells or treating cells with Akt and NF-kappaB inhibitors, LY294002 and parthenolide, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	AKT serine/threonine kinase 1	Homo sapiens	19-22
23383347-6	2013	The involvement of Akt and NF-kappaB signaling pathways in the EGF-induced IL-1beta gene expression was confirmed by knockdown of RelA and Akt in cells or treating cells with Akt and NF-kappaB inhibitors, LY294002 and parthenolide, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	nuclear factor kappa B subunit 1	Homo sapiens	27-36
23383347-6	2013	The involvement of Akt and NF-kappaB signaling pathways in the EGF-induced IL-1beta gene expression was confirmed by knockdown of RelA and Akt in cells or treating cells with Akt and NF-kappaB inhibitors, LY294002 and parthenolide, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	epidermal growth factor	Homo sapiens	63-66
23383347-6	2013	The involvement of Akt and NF-kappaB signaling pathways in the EGF-induced IL-1beta gene expression was confirmed by knockdown of RelA and Akt in cells or treating cells with Akt and NF-kappaB inhibitors, LY294002 and parthenolide, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	interleukin 1 beta	Homo sapiens	75-83
23383347-8	2013	Using immunofluorescence staining assay, the EGF-stimulated nuclear translocation of NF-kappaB (p65) was inhibited by pre-treating cells with LY294002 and parthenolide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	epidermal growth factor	Homo sapiens	45-48
23383347-8	2013	Using immunofluorescence staining assay, the EGF-stimulated nuclear translocation of NF-kappaB (p65) was inhibited by pre-treating cells with LY294002 and parthenolide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	nuclear factor kappa B subunit 1	Homo sapiens	85-94
23383347-8	2013	Using immunofluorescence staining assay, the EGF-stimulated nuclear translocation of NF-kappaB (p65) was inhibited by pre-treating cells with LY294002 and parthenolide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	RELA proto-oncogene, NF-kB subunit	Homo sapiens	96-99
23372675-12	2013	Furthermore, introduction of PTEN cDNA lacking 3"-UTR or PI3K inhibitor LY294002 abrogated miR-221-induced cisplatin resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	phosphatase and tensin homolog	Homo sapiens	29-33
23372675-12	2013	Furthermore, introduction of PTEN cDNA lacking 3"-UTR or PI3K inhibitor LY294002 abrogated miR-221-induced cisplatin resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	microRNA 221	Homo sapiens	91-98
23143065-7	2013	A specific PI3K inhibitor, LY294002, attenuated the inhibition of nitrite production and iNOS expression produced by overexpressing a liver-specific Epac2 (LEpac2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	Rap guanine nucleotide exchange factor 4	Homo sapiens	149-154
23000625-8	2012	This effect was changed by both the protein kinase A (PKA) inhibitor H89 (P&lt;0.01, P&lt;0.05, respectively, vs. Ex-4 group) and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (P&lt;0.01, P&lt;0.01, respectively, vs. Ex-4 group) but not by the mitogen-activated protein kinase (MAPK) inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	134-163
22980246-7	2013	However, XJP-1 alone upregulation of Akt and eNOS phosphorylation were blocked by LY294002 and SH-6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	37-40
23326131-11	2012	Furthermore, p-Akt and MMP9 was down-regulated in response to the inhibitor LY294002 (p-Akt 100.00% +- 8.87% vs 58.27% +- 5.01%, P &lt; 0.05; MMP9 100.00% +- 9.17% vs 50.03% +- 4.88%, P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	15-18
23326131-11	2012	Furthermore, p-Akt and MMP9 was down-regulated in response to the inhibitor LY294002 (p-Akt 100.00% +- 8.87% vs 58.27% +- 5.01%, P &lt; 0.05; MMP9 100.00% +- 9.17% vs 50.03% +- 4.88%, P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	matrix metallopeptidase 9	Homo sapiens	23-27
23326131-11	2012	Furthermore, p-Akt and MMP9 was down-regulated in response to the inhibitor LY294002 (p-Akt 100.00% +- 8.87% vs 58.27% +- 5.01%, P &lt; 0.05; MMP9 100.00% +- 9.17% vs 50.03% +- 4.88%, P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	88-91
23326131-11	2012	Furthermore, p-Akt and MMP9 was down-regulated in response to the inhibitor LY294002 (p-Akt 100.00% +- 8.87% vs 58.27% +- 5.01%, P &lt; 0.05; MMP9 100.00% +- 9.17% vs 50.03% +- 4.88%, P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	matrix metallopeptidase 9	Homo sapiens	142-146
23129756-8	2012	The PI3K/AKT inhibitor Ly294002 inhibited S1P-directed migration by Th1 cells, whereas the ERK inhibitor U0126 inhibited Th2 cell S1P-directed migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	thymoma viral proto-oncogene 1	Mus musculus	9-12
23129756-8	2012	The PI3K/AKT inhibitor Ly294002 inhibited S1P-directed migration by Th1 cells, whereas the ERK inhibitor U0126 inhibited Th2 cell S1P-directed migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	negative elongation factor complex member C/D, Th1l	Mus musculus	68-71
22998497-13	2013	While expression of a constitutively active Akt in BCPAP and TPC1 cells rendered them resistant to TRAIL, pretreating KTC1 and FTC133 cells with LY294002 rendered them TRAIL-sensitive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	TNF superfamily member 10	Homo sapiens	168-173
23157418-8	2012	For example, the predicted RESP and QPLD free energies of -9.5 and -9.3 kcal/mol for LY294002 binding to PI3Kgamma and -10.9 and -11.7 kcal/mol for wortmannin binding to PI3Kalpha are in good agreement with experimental values.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	105-114
23157418-8	2012	For example, the predicted RESP and QPLD free energies of -9.5 and -9.3 kcal/mol for LY294002 binding to PI3Kgamma and -10.9 and -11.7 kcal/mol for wortmannin binding to PI3Kalpha are in good agreement with experimental values.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	170-179
23063715-10	2012	Interestingly, Tan IIA significantly increased the phosphorylation of AKT in primary cortical neuronal culture exposed to OGD, which was abolished by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	AKT serine/threonine kinase 1	Rattus norvegicus	70-73
23208416-8	2012	Inhibition of GIP expression by the PI3/AKT inhibitor, LY294002, was abrogated in STC-1 cells with reduced menin levels, whereas the MAPK inhibitor, UO126, inhibited the expression of GIP independent of menin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	gastric inhibitory polypeptide	Mus musculus	14-17
23142719-9	2012	LY294002 abrogated the ability of alpha-crystallin to phosphorylate Akt and mTOR, and decreased the percentage of cells in S and G2/M stage which were treated with alpha-crystallin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	68-71
23142719-9	2012	LY294002 abrogated the ability of alpha-crystallin to phosphorylate Akt and mTOR, and decreased the percentage of cells in S and G2/M stage which were treated with alpha-crystallin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	76-80
23208416-8	2012	Inhibition of GIP expression by the PI3/AKT inhibitor, LY294002, was abrogated in STC-1 cells with reduced menin levels, whereas the MAPK inhibitor, UO126, inhibited the expression of GIP independent of menin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	36-39
23208416-8	2012	Inhibition of GIP expression by the PI3/AKT inhibitor, LY294002, was abrogated in STC-1 cells with reduced menin levels, whereas the MAPK inhibitor, UO126, inhibited the expression of GIP independent of menin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	thymoma viral proto-oncogene 1	Mus musculus	40-43
23208416-8	2012	Inhibition of GIP expression by the PI3/AKT inhibitor, LY294002, was abrogated in STC-1 cells with reduced menin levels, whereas the MAPK inhibitor, UO126, inhibited the expression of GIP independent of menin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	multiple endocrine neoplasia 1	Mus musculus	107-112
23027625-7	2012	Moreover, tectorigenin-paclitaxel-induced cell growth inhibition was enhanced by pretreatment with the Akt inhibitor LY294002 or overexpression of the dominant negative Akt (Akt-DN), but reduced by overexpression of constitutively activated Akt (Akt-Myr).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	103-106
22957647-4	2012	We report here that chemopreventive agent flavone, phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, and histone deacetylase (HDAC) inhibitor trichostatin A (TSA) also induce G(1)  phase arrest in malignant tumor cells with mutated RB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	51-80
22957647-6	2012	LY294002 also dephosphorylated p107 and p130 proteins, whereas TSA dephosphorylated p130, but not p107.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	RB transcriptional corepressor like 1	Homo sapiens	31-35
22957647-6	2012	LY294002 also dephosphorylated p107 and p130 proteins, whereas TSA dephosphorylated p130, but not p107.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	RB transcriptional corepressor like 2	Homo sapiens	40-44
23167467-8	2012	Enamel matrix derivative-induced VEGF production was significantly attenuated by SB203580, U0126, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	vascular endothelial growth factor A	Homo sapiens	33-37
23191937-6	2012	Blocking the AKT/GSK3beta pathway via the AKT inhibitor LY294002 prior to limb RIPostC suppressed the RIPostC-induced autophagy and resulted in the activation of caspase-3 in RIPostC rats, suggesting a critical role for AKT/GSK3beta-dependent autophagy in reducing cell death after cerebral ischemia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
23191937-6	2012	Blocking the AKT/GSK3beta pathway via the AKT inhibitor LY294002 prior to limb RIPostC suppressed the RIPostC-induced autophagy and resulted in the activation of caspase-3 in RIPostC rats, suggesting a critical role for AKT/GSK3beta-dependent autophagy in reducing cell death after cerebral ischemia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	glycogen synthase kinase 3 beta	Rattus norvegicus	17-25
23191937-6	2012	Blocking the AKT/GSK3beta pathway via the AKT inhibitor LY294002 prior to limb RIPostC suppressed the RIPostC-induced autophagy and resulted in the activation of caspase-3 in RIPostC rats, suggesting a critical role for AKT/GSK3beta-dependent autophagy in reducing cell death after cerebral ischemia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Rattus norvegicus	42-45
23191937-6	2012	Blocking the AKT/GSK3beta pathway via the AKT inhibitor LY294002 prior to limb RIPostC suppressed the RIPostC-induced autophagy and resulted in the activation of caspase-3 in RIPostC rats, suggesting a critical role for AKT/GSK3beta-dependent autophagy in reducing cell death after cerebral ischemia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	caspase 3	Rattus norvegicus	162-171
23191937-6	2012	Blocking the AKT/GSK3beta pathway via the AKT inhibitor LY294002 prior to limb RIPostC suppressed the RIPostC-induced autophagy and resulted in the activation of caspase-3 in RIPostC rats, suggesting a critical role for AKT/GSK3beta-dependent autophagy in reducing cell death after cerebral ischemia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Rattus norvegicus	42-45
23191937-6	2012	Blocking the AKT/GSK3beta pathway via the AKT inhibitor LY294002 prior to limb RIPostC suppressed the RIPostC-induced autophagy and resulted in the activation of caspase-3 in RIPostC rats, suggesting a critical role for AKT/GSK3beta-dependent autophagy in reducing cell death after cerebral ischemia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	glycogen synthase kinase 3 beta	Rattus norvegicus	224-232
22729368-3	2012	We aimed to study whether Ly294002, an inhibitor of PI3K, could enhance the cytotoxicity of AG1478, an inhibitor of EGFR, on breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	epidermal growth factor receptor	Homo sapiens	116-120
22981793-7	2012	The PI3K inhibitor LY294002 inhibited basal CCL17 release from BAL cells and IL-4-stimulated release from MDMs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	interleukin 4	Homo sapiens	77-81
23226762-5	2012	The data also revealed that LY294002, an inhibitor of phosphoinositide-3-kinase (PI3K), decreased the VEGF-induced migration and VCAM-1 expression of BMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	vascular endothelial growth factor A	Rattus norvegicus	102-106
23226762-5	2012	The data also revealed that LY294002, an inhibitor of phosphoinositide-3-kinase (PI3K), decreased the VEGF-induced migration and VCAM-1 expression of BMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	vascular cell adhesion molecule 1	Rattus norvegicus	129-135
22981793-7	2012	The PI3K inhibitor LY294002 inhibited basal CCL17 release from BAL cells and IL-4-stimulated release from MDMs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	C-C motif chemokine ligand 17	Homo sapiens	44-49
23271286-7	2012	LY294002 (20 mumol/L) were used to pre-treat the neurons 30 min before H(2)O(2) treatment and selectively inhibit the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	118-147
23271286-7	2012	LY294002 (20 mumol/L) were used to pre-treat the neurons 30 min before H(2)O(2) treatment and selectively inhibit the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	155-158
23271286-12	2012	Blockade of PI3K/Akt pathway by LY294002 decreased the cell viability by 17% and increased the cell apoptosis rate by 2-fold.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	17-20
23271286-13	2012	LY294002 treatment could up-regulate the expression of the pro-apoptotic gene Bax by 12% and down-regulate the expression of the anti-apoptotic gene Bcl-2 by 54%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	78-81
23271286-13	2012	LY294002 treatment could up-regulate the expression of the pro-apoptotic gene Bax by 12% and down-regulate the expression of the anti-apoptotic gene Bcl-2 by 54%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2, apoptosis regulator	Rattus norvegicus	149-154
23271927-6	2012	Treatment with FSL-1 resulted in enhanced phosphorylation of Akt and mitogen-activated protein kinases and activation of protein kinase C. Treatment with pharmacological inhibitors, including SB202190, SP6001250, U0126, Akt inhibitor IV, LY294002, GF109203X, and RO318220 resulted in significantly attenuated FSL-1-mediated upregulation of CCL2 and IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	238-246	follistatin like 1	Homo sapiens	15-20
22729368-5	2012	Simultaneous inhibition of EGFR and PI3K in MDA-MB-468 cells with combined Ly294002 and AG1478 treatment had a greater anti-proliferative effect and increased mitotic death than either treatment alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	epidermal growth factor receptor	Homo sapiens	27-31
22729368-7	2012	Phosphor-EGFR and its downstream signal transducer, phosphor-Akt, were fully attenuated only by simultaneous treatment with Ly294002 and AG1478.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	epidermal growth factor receptor	Homo sapiens	9-13
22729368-7	2012	Phosphor-EGFR and its downstream signal transducer, phosphor-Akt, were fully attenuated only by simultaneous treatment with Ly294002 and AG1478.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	AKT serine/threonine kinase 1	Homo sapiens	61-64
23027183-6	2012	Using chemical inhibitors of insulin downstream pathways, we demonstrated that the insulin-induced Zbtb7A gene expression was completely blocked by LY294002, a PI3K/AKT inhibitor, and partially attenuated by the MAPK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	insulin	Homo sapiens	29-36
23027183-6	2012	Using chemical inhibitors of insulin downstream pathways, we demonstrated that the insulin-induced Zbtb7A gene expression was completely blocked by LY294002, a PI3K/AKT inhibitor, and partially attenuated by the MAPK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	insulin	Homo sapiens	83-90
23027183-6	2012	Using chemical inhibitors of insulin downstream pathways, we demonstrated that the insulin-induced Zbtb7A gene expression was completely blocked by LY294002, a PI3K/AKT inhibitor, and partially attenuated by the MAPK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	zinc finger and BTB domain containing 7A	Homo sapiens	99-105
23027183-6	2012	Using chemical inhibitors of insulin downstream pathways, we demonstrated that the insulin-induced Zbtb7A gene expression was completely blocked by LY294002, a PI3K/AKT inhibitor, and partially attenuated by the MAPK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Homo sapiens	165-168
22936120-8	2012	However, treatment with LY294002 or K252a reversed the quercetin-induced increase of BDNF and p-Akt proteins and decrease of cleaved caspase-3 protein in focal cerebral ischemia rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	brain-derived neurotrophic factor	Rattus norvegicus	85-89
23249714-5	2012	METHODS: Using real-time RT-PCR to analyze the EGFR mRNA expression level in EGFR wild-type non-small cell lung cancer (NSCLC) cells; MTT analysis detected the cytotoxicity for NSCLC cells to Erlotinib; Western blot analysis examined the mutant situations and the downstream signaling protein phosphorylation level in EGFR-mutant NSCLC cells with the treatment of Erlotinib or/and PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	397-405	epidermal growth factor receptor	Homo sapiens	47-51
23053478-3	2012	K(Ca)3.1 channel mRNA and protein levels were greatly enhanced in cardiac fibroblasts treated with 200 mug/ml AGE-BSA, and the effects were countered by anti-RAGE antibody or the ERK1/2 inhibitor PD98059, the p38-MAPK inhibitor SB203580, and the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	265-273	advanced glycosylation end product-specific receptor	Rattus norvegicus	158-162
23051850-9	2012	Luteolin also activated Akt and ERK, whereas the addition of LY294002 and U0126, the pharmacologic inhibitors of PI3K and ERK, attenuated luteolin-induced HO-1 expression and cytoprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	Eph receptor B1	Rattus norvegicus	122-125
23051850-9	2012	Luteolin also activated Akt and ERK, whereas the addition of LY294002 and U0126, the pharmacologic inhibitors of PI3K and ERK, attenuated luteolin-induced HO-1 expression and cytoprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	heme oxygenase 1	Rattus norvegicus	155-159
23290651-6	2012	RESULTS: HBE cell line exposed to silica can induce Akt phosphorylation, in which expressions of p-Akt were up regulated 1 times at 48 and the highest at 72 h. The expressions of TGFbeta increased remarkably at 12 h and the peak at 48 h after silica exposure, while the expressions of alpha-SMA increased at 24 h and the highest at 72 h. However, the PI3K inhibitor (Ly294002) significantly down regulated alpha-SMA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	367-375	AKT serine/threonine kinase 1	Homo sapiens	52-55
22975711-8	2012	ANP-induced GSK-3beta phosphorylation was also abolished by the PI3K inhibitor LY294002 [2-(4-morpholinyl-4H-1-benzopyran-4-one hydrochloride)] and ANP could not prevent H(2)O(2)-induced loss of DeltaPsi(m) in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	natriuretic peptide A	Rattus norvegicus	0-3
23290651-6	2012	RESULTS: HBE cell line exposed to silica can induce Akt phosphorylation, in which expressions of p-Akt were up regulated 1 times at 48 and the highest at 72 h. The expressions of TGFbeta increased remarkably at 12 h and the peak at 48 h after silica exposure, while the expressions of alpha-SMA increased at 24 h and the highest at 72 h. However, the PI3K inhibitor (Ly294002) significantly down regulated alpha-SMA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	367-375	AKT serine/threonine kinase 1	Homo sapiens	99-102
23290651-6	2012	RESULTS: HBE cell line exposed to silica can induce Akt phosphorylation, in which expressions of p-Akt were up regulated 1 times at 48 and the highest at 72 h. The expressions of TGFbeta increased remarkably at 12 h and the peak at 48 h after silica exposure, while the expressions of alpha-SMA increased at 24 h and the highest at 72 h. However, the PI3K inhibitor (Ly294002) significantly down regulated alpha-SMA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	367-375	transforming growth factor beta 1	Homo sapiens	179-186
22975711-8	2012	ANP-induced GSK-3beta phosphorylation was also abolished by the PI3K inhibitor LY294002 [2-(4-morpholinyl-4H-1-benzopyran-4-one hydrochloride)] and ANP could not prevent H(2)O(2)-induced loss of DeltaPsi(m) in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	glycogen synthase kinase 3 beta	Rattus norvegicus	12-21
22975711-8	2012	ANP-induced GSK-3beta phosphorylation was also abolished by the PI3K inhibitor LY294002 [2-(4-morpholinyl-4H-1-benzopyran-4-one hydrochloride)] and ANP could not prevent H(2)O(2)-induced loss of DeltaPsi(m) in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	natriuretic peptide A	Rattus norvegicus	148-151
22975711-8	2012	ANP-induced GSK-3beta phosphorylation was also abolished by the PI3K inhibitor LY294002 [2-(4-morpholinyl-4H-1-benzopyran-4-one hydrochloride)] and ANP could not prevent H(2)O(2)-induced loss of DeltaPsi(m) in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	226-234	natriuretic peptide A	Rattus norvegicus	0-3
22975711-8	2012	ANP-induced GSK-3beta phosphorylation was also abolished by the PI3K inhibitor LY294002 [2-(4-morpholinyl-4H-1-benzopyran-4-one hydrochloride)] and ANP could not prevent H(2)O(2)-induced loss of DeltaPsi(m) in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	226-234	glycogen synthase kinase 3 beta	Rattus norvegicus	12-21
23187004-5	2012	Pretreatment with Ly294002, a PI3K inhibitor, augmented the decrease in HO-1 level by their combination, whereas no obvious changes were observed in Nrf2 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	heme oxygenase 1	Homo sapiens	72-76
23026832-7	2012	The PI3K/Akt inhibitor LY294002 enhanced the apoptosis-inducing effect of ISO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	9-12
23026832-8	2012	However, LY294002 markedly quenched ROS and NO generation and diminished the protein expression of heme peroxidase enzyme (HO-1) and inducible nitric oxide synthase (iNOS).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	heme oxygenase 1	Homo sapiens	123-127
23026832-8	2012	However, LY294002 markedly quenched ROS and NO generation and diminished the protein expression of heme peroxidase enzyme (HO-1) and inducible nitric oxide synthase (iNOS).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	nitric oxide synthase 2	Homo sapiens	133-164
23026832-8	2012	However, LY294002 markedly quenched ROS and NO generation and diminished the protein expression of heme peroxidase enzyme (HO-1) and inducible nitric oxide synthase (iNOS).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	nitric oxide synthase 2	Homo sapiens	166-170
22995516-6	2012	Interestingly, GPIb-induced activation of Rac1 and the guanine nucleotide exchange factor for Rac1, Vav, was abolished in both Lyn(-/-) and SFK inhibitor-treated platelets but was unaffected by the PI3K inhibitor LY294002, indicating that Lyn mediates activation of Vav and Rac1 independently of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	Rac family small GTPase 1	Mus musculus	42-46
22995516-6	2012	Interestingly, GPIb-induced activation of Rac1 and the guanine nucleotide exchange factor for Rac1, Vav, was abolished in both Lyn(-/-) and SFK inhibitor-treated platelets but was unaffected by the PI3K inhibitor LY294002, indicating that Lyn mediates activation of Vav and Rac1 independently of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	Rac family small GTPase 1	Mus musculus	94-98
22995516-6	2012	Interestingly, GPIb-induced activation of Rac1 and the guanine nucleotide exchange factor for Rac1, Vav, was abolished in both Lyn(-/-) and SFK inhibitor-treated platelets but was unaffected by the PI3K inhibitor LY294002, indicating that Lyn mediates activation of Vav and Rac1 independently of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	vav 1 oncogene	Mus musculus	100-103
22995516-6	2012	Interestingly, GPIb-induced activation of Rac1 and the guanine nucleotide exchange factor for Rac1, Vav, was abolished in both Lyn(-/-) and SFK inhibitor-treated platelets but was unaffected by the PI3K inhibitor LY294002, indicating that Lyn mediates activation of Vav and Rac1 independently of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	Rac family small GTPase 1	Mus musculus	94-98
22909461-6	2012	PCA enhanced the phosphorylation of Akt, which could be blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Homo sapiens	36-39
23106660-11	2012	The PI3K-specific inhibitor LY294002 also completely attenuated IL-25-induced bFGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	interleukin 25	Homo sapiens	64-69
23106660-11	2012	The PI3K-specific inhibitor LY294002 also completely attenuated IL-25-induced bFGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	fibroblast growth factor 2	Homo sapiens	78-82
22828749-13	2012	Finally, intra-BLA infusions of LY294002 (5 mM/side), a specific phosphatidylinositol 3-kinase (PI3K) inhibitor, significantly blocked the antidepressant-like effect of TFF3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	65-94
22941773-4	2012	In contrast, the PI3K/Akt inhibitor LY294002 and the PDE3B antagonist cilostamide enhanced LA-induced lipolysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	22-25
23050643-6	2012	Blockade of Akt phosphorylation with the PI3-kinase inhibitor LY294002 negated this vascular neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	AKT serine/threonine kinase 1	Homo sapiens	12-15
22949725-4	2012	Both FSH- and AREG-induced cumulus expansion was incompletely inhibited by H89 and completely inhibited by SB203580, U0126, AG1478, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	amphiregulin	Sus scrofa	14-18
22249269-7	2012	Blocking the phosphoinoside 3-kinase (PI3K)/Akt pathway with LY294002 or si-Akt also suppressed the self-renewal of sphere-cultured glioma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	13-36
22249269-7	2012	Blocking the phosphoinoside 3-kinase (PI3K)/Akt pathway with LY294002 or si-Akt also suppressed the self-renewal of sphere-cultured glioma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Homo sapiens	44-47
22949725-3	2012	Amphiregulin (AREG)-induced maturation of oocytes was efficiently blocked in GV by U0126, AG1478, and low concentrations of LY294002; H89, SB203580, and high concentrations of LY294002 allowed the oocytes to undergo breakdown of GV and blocked maturation in MI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	amphiregulin	Sus scrofa	0-12
22949725-3	2012	Amphiregulin (AREG)-induced maturation of oocytes was efficiently blocked in GV by U0126, AG1478, and low concentrations of LY294002; H89, SB203580, and high concentrations of LY294002 allowed the oocytes to undergo breakdown of GV and blocked maturation in MI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	amphiregulin	Sus scrofa	14-18
22949725-3	2012	Amphiregulin (AREG)-induced maturation of oocytes was efficiently blocked in GV by U0126, AG1478, and low concentrations of LY294002; H89, SB203580, and high concentrations of LY294002 allowed the oocytes to undergo breakdown of GV and blocked maturation in MI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	amphiregulin	Sus scrofa	0-12
22828749-13	2012	Finally, intra-BLA infusions of LY294002 (5 mM/side), a specific phosphatidylinositol 3-kinase (PI3K) inhibitor, significantly blocked the antidepressant-like effect of TFF3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	trefoil factor 3	Rattus norvegicus	169-173
22884465-7	2012	The neuroprotection of PREGS, PRE084 or DMXB was blocked by the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002, whereas only the effect of PREGS or PRE084 was sensitive to the MAPK/ERK kinase (MEK) inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	mitogen-activated protein kinase 1	Mus musculus	185-189
22956516-8	2012	However, western blot analyses coupled with pretreatment of cells with the PI3K inhibitor LY294002 indicated that the synergistic effect of cAMP and IGF1 on transcript levels was due in part to cooperative increases in Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	insulin-like growth factor 1	Mus musculus	149-153
22949725-3	2012	Amphiregulin (AREG)-induced maturation of oocytes was efficiently blocked in GV by U0126, AG1478, and low concentrations of LY294002; H89, SB203580, and high concentrations of LY294002 allowed the oocytes to undergo breakdown of GV and blocked maturation in MI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	amphiregulin	Sus scrofa	14-18
22956516-8	2012	However, western blot analyses coupled with pretreatment of cells with the PI3K inhibitor LY294002 indicated that the synergistic effect of cAMP and IGF1 on transcript levels was due in part to cooperative increases in Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	thymoma viral proto-oncogene 1	Mus musculus	219-222
22942286-6	2012	Both SARA and PI3K have been shown to be associated with endosomes, and either LY294002 or p85alpha knockdown enlarged SARA-containing endocytic vesicles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	zinc finger FYVE-type containing 9	Homo sapiens	119-123
22972933-2	2012	In this article, we show that inhibition of autophagy, either with the PI3K inhibitors 3-methyladenine, wortmannin, and LY294002 or with small interfering RNA against autophagy proteins augmented the secretion of IL-23 by human and mouse macrophages and dendritic cells in response to specific TLR agonists.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	interleukin 23 subunit alpha	Homo sapiens	213-218
23050488-10	2012	In line with these results, the protective effect of adiponectin can be blocked by PI3K/Akt inhibitor LY294002, and palmitate-induced apoptosis can be attenuated by ERK1/2 inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	53-64
23050488-10	2012	In line with these results, the protective effect of adiponectin can be blocked by PI3K/Akt inhibitor LY294002, and palmitate-induced apoptosis can be attenuated by ERK1/2 inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	AKT serine/threonine kinase 1	Rattus norvegicus	88-91
22927331-5	2012	CXCL16 increased Akt phosphorylation (Thr(308)/Ser(473)), an effect abrogated by phosphatidylinositide 3-kinase inhibitors wortmannin (100 nmol/L) and LY294002 (25 micromol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	C-X-C motif chemokine ligand 16	Homo sapiens	0-6
22927331-5	2012	CXCL16 increased Akt phosphorylation (Thr(308)/Ser(473)), an effect abrogated by phosphatidylinositide 3-kinase inhibitors wortmannin (100 nmol/L) and LY294002 (25 micromol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	AKT serine/threonine kinase 1	Homo sapiens	17-20
23369170-0	2012	Versatile inhibitory effects of the flavonoid-derived PI3K/Akt inhibitor, LY294002, on ATP-binding cassette transporters that characterize stem cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	59-62
23369170-9	2012	On the other hand, a PI3K inhibitor, LY294002, reversed multidrug resistance in cancer cells that overexpress BCRP not by affecting BCRP translocation but putatively as a competitive inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	110-114
23369170-9	2012	On the other hand, a PI3K inhibitor, LY294002, reversed multidrug resistance in cancer cells that overexpress BCRP not by affecting BCRP translocation but putatively as a competitive inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	132-136
23369170-13	2012	LY294002 has also been reported to exert inhibitory effects on multidrug resistance-associated protein 1 (MRP1) function via dual mechanisms, competitive block of substrate transport and modulation of expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ATP binding cassette subfamily C member 1	Homo sapiens	63-104
23369170-13	2012	LY294002 has also been reported to exert inhibitory effects on multidrug resistance-associated protein 1 (MRP1) function via dual mechanisms, competitive block of substrate transport and modulation of expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ATP binding cassette subfamily C member 1	Homo sapiens	106-110
23369170-15	2012	Taken together, LY294002 can inhibit all BCRP, P-glycoprotein, and MRP1, which are three major ABC transporters that are highly expressed in stem cells and cause multidrug resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	41-45
23369170-15	2012	Taken together, LY294002 can inhibit all BCRP, P-glycoprotein, and MRP1, which are three major ABC transporters that are highly expressed in stem cells and cause multidrug resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	ATP binding cassette subfamily C member 1	Homo sapiens	67-71
22841670-7	2012	It was also found that the inhibition of Akt expression and phosphorylation was involved in apoptosis induction, and specific Akt inhibitor LY294002 or siRNA targeting Akt can synergistically enhanced bufotalin-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	AKT serine/threonine kinase 1	Homo sapiens	41-44
22841670-7	2012	It was also found that the inhibition of Akt expression and phosphorylation was involved in apoptosis induction, and specific Akt inhibitor LY294002 or siRNA targeting Akt can synergistically enhanced bufotalin-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	AKT serine/threonine kinase 1	Homo sapiens	126-129
22841670-7	2012	It was also found that the inhibition of Akt expression and phosphorylation was involved in apoptosis induction, and specific Akt inhibitor LY294002 or siRNA targeting Akt can synergistically enhanced bufotalin-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	AKT serine/threonine kinase 1	Homo sapiens	126-129
23043709-9	2012	When podocytes were pretreated with anti-RAGE antibody (50 microg/ml) or the phosphoinositide 3-kinase (PI3-K) inhibitor, LY294002 (10 microM), the AGEs-induced increases in AGT and AT1R expression were reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	77-102
23043709-9	2012	When podocytes were pretreated with anti-RAGE antibody (50 microg/ml) or the phosphoinositide 3-kinase (PI3-K) inhibitor, LY294002 (10 microM), the AGEs-induced increases in AGT and AT1R expression were reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	174-177
23043709-9	2012	When podocytes were pretreated with anti-RAGE antibody (50 microg/ml) or the phosphoinositide 3-kinase (PI3-K) inhibitor, LY294002 (10 microM), the AGEs-induced increases in AGT and AT1R expression were reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	angiotensin II, type I receptor-associated protein	Mus musculus	182-186
22817531-9	2012	Furthermore, administration of LY294002, an inhibitor of PI3-K, compromised the neuroprotective effect of resveratrol and decreased the level of p-Akt, p-GSK-3beta and p-CREB after ischemic injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Rattus norvegicus	147-150
25538739-5	2012	In addition, the high levels of telencephalin, phosphorylated ezrin/radixin/moesin and phosphatidylinositol-3-kinase/protein kinase B expression in PAJU cells transfected with a telencephalin expression plasmid could be suppressed by the phosphatidylinositol-3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	278-286	intercellular adhesion molecule 5	Homo sapiens	178-191
22556157-8	2012	LY294002 and wortmannin inhibited TNF-alpha-induced Akt activation, whereas only LY294002 inhibited CD38 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Homo sapiens	34-43
22556157-8	2012	LY294002 and wortmannin inhibited TNF-alpha-induced Akt activation, whereas only LY294002 inhibited CD38 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	52-55
22556157-8	2012	LY294002 and wortmannin inhibited TNF-alpha-induced Akt activation, whereas only LY294002 inhibited CD38 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	CD38 molecule	Homo sapiens	100-104
22841831-9	2012	Protein kinase A (PKA) inhibitor H89 promoted nuclear export of Id1, and phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 reduced the nuclear export of Id1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	inhibitor of DNA binding 1, HLH protein	Homo sapiens	159-162
22791810-6	2012	Thereby, Ruk(l)/CIN85 led to a more rapid and prolonged epidermal growth factor-dependent activation of Src, Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk(l)/CIN85-dependent changes in cell motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	SH3 domain containing kinase binding protein 1	Homo sapiens	16-21
22791810-6	2012	Thereby, Ruk(l)/CIN85 led to a more rapid and prolonged epidermal growth factor-dependent activation of Src, Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk(l)/CIN85-dependent changes in cell motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	epidermal growth factor	Homo sapiens	56-79
22791810-6	2012	Thereby, Ruk(l)/CIN85 led to a more rapid and prolonged epidermal growth factor-dependent activation of Src, Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk(l)/CIN85-dependent changes in cell motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	104-107
22817531-9	2012	Furthermore, administration of LY294002, an inhibitor of PI3-K, compromised the neuroprotective effect of resveratrol and decreased the level of p-Akt, p-GSK-3beta and p-CREB after ischemic injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	glycogen synthase kinase 3 beta	Rattus norvegicus	154-163
22817531-9	2012	Furthermore, administration of LY294002, an inhibitor of PI3-K, compromised the neuroprotective effect of resveratrol and decreased the level of p-Akt, p-GSK-3beta and p-CREB after ischemic injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	cAMP responsive element binding protein 1	Rattus norvegicus	170-174
23054633-7	2012	Moreover, LY294002 inhibited the phosphorylated-Akt expression evoked by SFN, decreased Bcl-2 expression and increased cleaved caspase-3 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	48-51
22644804-4	2012	Furthermore, we confirmed that the inhibition of phosphotidyl inositol 3-kinase (PI3K)/Akt pathway with LY294002 or Akt shRNA vector blocked the effect of high glucose on XBP-1 splicing and cellular triglyceride.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	49-79
22644804-4	2012	Furthermore, we confirmed that the inhibition of phosphotidyl inositol 3-kinase (PI3K)/Akt pathway with LY294002 or Akt shRNA vector blocked the effect of high glucose on XBP-1 splicing and cellular triglyceride.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	AKT serine/threonine kinase 1	Homo sapiens	87-90
22644804-4	2012	Furthermore, we confirmed that the inhibition of phosphotidyl inositol 3-kinase (PI3K)/Akt pathway with LY294002 or Akt shRNA vector blocked the effect of high glucose on XBP-1 splicing and cellular triglyceride.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	X-box binding protein 1	Homo sapiens	171-176
22806319-8	2012	To further investigate the effect of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in miR-1-induced injury, H9c2 cells were pretreated with LY294002 (10 muM LY, a specific inhibitor of PI3K) with or without insulin (100 nM) and subjected to H(2)O(2) treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	microRNA 1	Rattus norvegicus	93-98
22749925-8	2012	Inhibiting phosphorylation of Akt and FoxOs with LY294002 suppressed the postconditioning-induced neuroprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Rattus norvegicus	30-33
22695936-5	2012	RESULTS: Insulin or (and) high glucose significantly increased intracellular ROS production in BRECs, and pretreatment of the cells with apocynin and LY294002 decreased insulin-induced superoxide anion production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	insulin	Bos taurus	9-16
22695936-5	2012	RESULTS: Insulin or (and) high glucose significantly increased intracellular ROS production in BRECs, and pretreatment of the cells with apocynin and LY294002 decreased insulin-induced superoxide anion production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	insulin	Bos taurus	169-176
22817682-7	2012	This up-regulated FMRP expression was abolished by pre-treatment with PI3K and Protein Kinase B (Akt) inhibitors: LY294002, Akt inhibitor IV, and VIII.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	fragile X messenger ribonucleoprotein 1	Rattus norvegicus	18-22
22817682-7	2012	This up-regulated FMRP expression was abolished by pre-treatment with PI3K and Protein Kinase B (Akt) inhibitors: LY294002, Akt inhibitor IV, and VIII.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
23054633-7	2012	Moreover, LY294002 inhibited the phosphorylated-Akt expression evoked by SFN, decreased Bcl-2 expression and increased cleaved caspase-3 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	BCL2, apoptosis regulator	Rattus norvegicus	88-93
22744337-11	2012	In addition, LY294002 (a phosphoinositide-3-kinase inhibitor), which has been shown to inhibit cAMP-induced NTCP translocation, also inhibited cAMP-induced PKCdelta translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	solute carrier family 10 member 1	Homo sapiens	108-112
22925659-6	2012	LY294002 and U0126, inhibitors of PI3K and ERK1/2, respectively, reduced H2O2 generation in concentration-dependent manners.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 3	Homo sapiens	43-49
22581584-8	2012	Most interestingly, the pretreatment with the PI3-K inhibitor LY294002 significantly enhanced doxorubicin-induced apoptosis and diminished the Mcl-1 expression in ADAM10-overexpressing Huh7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	143-148
22581584-8	2012	Most interestingly, the pretreatment with the PI3-K inhibitor LY294002 significantly enhanced doxorubicin-induced apoptosis and diminished the Mcl-1 expression in ADAM10-overexpressing Huh7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	ADAM metallopeptidase domain 10	Homo sapiens	163-169
22581584-8	2012	Most interestingly, the pretreatment with the PI3-K inhibitor LY294002 significantly enhanced doxorubicin-induced apoptosis and diminished the Mcl-1 expression in ADAM10-overexpressing Huh7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	MIR7-3 host gene	Homo sapiens	185-189
22924393-3	2012	To selectively target advanced prostate tumors with a constitutive activated PI3K/Akt pathway, a prostate cancer-specific PI3K inhibitor was generated by coupling the chemically modified form of the quercetin analogue LY294002 (HO-CH(2)-LY294002, compound 8) with the peptide Mu-LEHSSKLQL, in which the internal sequence HSSKLQ is a substrate for the prostate-specific antigen (PSA) protease.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	AKT serine/threonine kinase 1	Homo sapiens	82-85
22771629-6	2012	Pharmacological inhibition with LY294002, wortmanin or PD98059 reduces Ft1-induced angiogenesis, indicating the important role played by these pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT interacting protein	Homo sapiens	71-74
22829589-6	2012	In addition, treatment of cells with LY294002, an inhibitor of PI 3-kinase, or mutations of the PX domain reduces tyrosine phosphorylation and membrane translocation of Tks4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	SH3 and PX domains 2B	Homo sapiens	169-173
22744337-11	2012	In addition, LY294002 (a phosphoinositide-3-kinase inhibitor), which has been shown to inhibit cAMP-induced NTCP translocation, also inhibited cAMP-induced PKCdelta translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	protein kinase C delta	Homo sapiens	156-164
22728329-8	2012	AS or Ly294002, but not H-89, decreased PKB/Akt activation as well as the nuclear localization of beta-catenin and cyclin D1 and increased the plasma membrane localization of beta-catenin with E-cadherin, suggesting that these processes are regulated by the PKB pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	catenin beta 1	Homo sapiens	175-187
22824823-5	2012	Simultaneously, the apoptosis induced by MATP was reversed by SP600125 (a JNK inhibitor) whereas it was aggravated by LY294002 (an Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	AKT serine/threonine kinase 1	Homo sapiens	131-134
22728329-8	2012	AS or Ly294002, but not H-89, decreased PKB/Akt activation as well as the nuclear localization of beta-catenin and cyclin D1 and increased the plasma membrane localization of beta-catenin with E-cadherin, suggesting that these processes are regulated by the PKB pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	catenin beta 1	Homo sapiens	98-110
22728329-8	2012	AS or Ly294002, but not H-89, decreased PKB/Akt activation as well as the nuclear localization of beta-catenin and cyclin D1 and increased the plasma membrane localization of beta-catenin with E-cadherin, suggesting that these processes are regulated by the PKB pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	cadherin 1	Homo sapiens	193-203
22728329-8	2012	AS or Ly294002, but not H-89, decreased PKB/Akt activation as well as the nuclear localization of beta-catenin and cyclin D1 and increased the plasma membrane localization of beta-catenin with E-cadherin, suggesting that these processes are regulated by the PKB pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	cyclin D1	Homo sapiens	115-124
22511233-7	2012	In contrast, LY294002 (a PI3K inhibitor) blocked Mal-C-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	heme oxygenase 1	Rattus norvegicus	63-67
22895065-2	2012	BEZ235 was more potent than either the mTOR inhibitor rapamycin or the PI3K inhibitor LY294002 in blocking HIF-1alpha induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	hypoxia-inducible factor 1-alpha	Ovis aries	107-117
22511233-9	2012	Treatment of RASMCs with Mal-C increased nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2), which is a key regulator of HO-1 expression, and this translocation was also inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-207	NFE2 like bZIP transcription factor 2	Rattus norvegicus	102-106
22511233-9	2012	Treatment of RASMCs with Mal-C increased nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2), which is a key regulator of HO-1 expression, and this translocation was also inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-207	heme oxygenase 1	Rattus norvegicus	137-141
22562815-8	2012	The results also demonstrated that LY294002, an inhibitor of phosphoinositide-3-kinase (PI3K), significantly inhibited the glioma-induced upregulation of VCAM-1 on BMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	61-86
22562815-8	2012	The results also demonstrated that LY294002, an inhibitor of phosphoinositide-3-kinase (PI3K), significantly inhibited the glioma-induced upregulation of VCAM-1 on BMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	vascular cell adhesion molecule 1	Homo sapiens	154-160
22985566-3	2012	RESULTS: Blocking PI3K/AKT/mTOR pathway with rapamycin and LY294002 significantly reduced drug resistance of both A549 and A549/CDDP cells to cisplatin and obviously decreased the expression of CA916798 gene mRNA (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	23-26
22580375-10	2012	Finally, pharmacological experiments showed that administration of inhibitors of either MAPK/ERK (U0126) or PI3K (LY294002) blocked VEGF-stimulation of hippocampal cell proliferation in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	vascular endothelial growth factor A	Rattus norvegicus	132-136
23156673-3	2012	Also, MAP-2 expression and neurite outgrowth were much increased with activation of serine/threonine protein kinase (Akt) and blocked by addition of an Akt inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	microtubule associated protein 2	Homo sapiens	6-11
23156673-3	2012	Also, MAP-2 expression and neurite outgrowth were much increased with activation of serine/threonine protein kinase (Akt) and blocked by addition of an Akt inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	AKT serine/threonine kinase 1	Homo sapiens	117-120
23156673-3	2012	Also, MAP-2 expression and neurite outgrowth were much increased with activation of serine/threonine protein kinase (Akt) and blocked by addition of an Akt inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	AKT serine/threonine kinase 1	Homo sapiens	152-155
22710837-5	2012	Herein,             we show that AD-PTEN significantly enhanced the sensitization of breast cancer             cells to LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	phosphatase and tensin homolog	Homo sapiens	33-40
22710837-7	2012	In addition, treatment of AD-PTEN-transfected cells with LY294002 resulted             in significantly reduced cell viability and invasion ability compared to single             LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	phosphatase and tensin homolog	Homo sapiens	26-33
22710837-7	2012	In addition, treatment of AD-PTEN-transfected cells with LY294002 resulted             in significantly reduced cell viability and invasion ability compared to single             LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	phosphatase and tensin homolog	Homo sapiens	26-33
22710837-10	2012	Our results indicate             that AD-PTEN sensitization of breast cancer to LY294002 is achieved by increased             GSK-3beta activity, thus resulting in inhibition of the beta-catenin signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	phosphatase and tensin homolog	Homo sapiens	38-45
22710837-10	2012	Our results indicate             that AD-PTEN sensitization of breast cancer to LY294002 is achieved by increased             GSK-3beta activity, thus resulting in inhibition of the beta-catenin signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	glycogen synthase kinase 3 beta	Homo sapiens	126-135
22710837-10	2012	Our results indicate             that AD-PTEN sensitization of breast cancer to LY294002 is achieved by increased             GSK-3beta activity, thus resulting in inhibition of the beta-catenin signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	catenin beta 1	Homo sapiens	182-194
22339667-5	2012	The inhibition of phosphoinositide 3 kinase (PI3K) (via LY294002), an early second messenger of the insulin receptor, blocked this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	18-43
22985566-3	2012	RESULTS: Blocking PI3K/AKT/mTOR pathway with rapamycin and LY294002 significantly reduced drug resistance of both A549 and A549/CDDP cells to cisplatin and obviously decreased the expression of CA916798 gene mRNA (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	mechanistic target of rapamycin kinase	Homo sapiens	27-31
22809514-10	2012	The increase of SGK1 protein abundance is blunted by inhibition of PI3K with wortmannin (100 nM) or LY294002 (25 muM), and by disruption of the cytoskeleton with cytochalasin B (1 muM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	serum/glucocorticoid regulated kinase 1	Homo sapiens	16-20
22828512-12	2012	Accordingly, inhibition of MEK/ERK-signaling by UO126 or inhibition of PI3K/Akt-signaling by LY294002 abolished the anti-apoptotic effects of ATP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Homo sapiens	76-79
22819846-6	2012	Application of LY294002, a PI3K inhibitor, attenuated the HDGF-induced migration, dorsal ruffles and podosome rosettes formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	heparin binding growth factor	Mus musculus	58-62
22819846-7	2012	Consistently, the HDGF-overexpressing NIH/3T3 transfectants exhibited significantly increased motility and elevated PI3K/Akt activities, which were repressed by LY294002 or adenovirus-mediated overexpression of endogenous PI3K antagonist, PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	heparin binding growth factor	Mus musculus	18-22
22819846-7	2012	Consistently, the HDGF-overexpressing NIH/3T3 transfectants exhibited significantly increased motility and elevated PI3K/Akt activities, which were repressed by LY294002 or adenovirus-mediated overexpression of endogenous PI3K antagonist, PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	thymoma viral proto-oncogene 1	Mus musculus	121-124
22819846-7	2012	Consistently, the HDGF-overexpressing NIH/3T3 transfectants exhibited significantly increased motility and elevated PI3K/Akt activities, which were repressed by LY294002 or adenovirus-mediated overexpression of endogenous PI3K antagonist, PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	phosphatase and tensin homolog	Mus musculus	239-243
22820188-5	2012	Suppression Akt/mTOR complex 1(mTORC1) activation by LY 294002 and rapamycin inhibited TNF-alpha-mediated MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-62	AKT serine/threonine kinase 1	Homo sapiens	12-15
22820188-5	2012	Suppression Akt/mTOR complex 1(mTORC1) activation by LY 294002 and rapamycin inhibited TNF-alpha-mediated MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-62	CREB regulated transcription coactivator 1	Mus musculus	31-37
22820188-5	2012	Suppression Akt/mTOR complex 1(mTORC1) activation by LY 294002 and rapamycin inhibited TNF-alpha-mediated MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-62	tumor necrosis factor	Homo sapiens	87-96
22371121-9	2012	However, pretreatment with LY294002 significantly diminished IL-1beta-induced proliferation, migration, adhesion, and VEGF-A production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	interleukin 1 beta	Homo sapiens	61-69
22820188-5	2012	Suppression Akt/mTOR complex 1(mTORC1) activation by LY 294002 and rapamycin inhibited TNF-alpha-mediated MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-62	matrix metallopeptidase 9	Homo sapiens	106-111
22897902-15	2012	The upregulation of LASP-1 was inhibited after treatment with LY294002, PI3-K pathway inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	LIM and SH3 protein 1	Homo sapiens	20-26
22809065-6	2012	This response was strongly inhibited by pretreatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, indicating that eriodictyol increased Akt phosphorylation by activating the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	AKT serine/threonine kinase 1	Homo sapiens	157-160
22809065-6	2012	This response was strongly inhibited by pretreatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, indicating that eriodictyol increased Akt phosphorylation by activating the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	AKT serine/threonine kinase 1	Homo sapiens	200-203
22369073-9	2012	Hypoxia induced IL-1beta expression in C2C12 myoblast cells, which was inhibited by pre-incubation with ACh (acetylcholine) or LY294002, a PI3K (phosphoinositide 3-kinase) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	interleukin 1 beta	Mus musculus	16-24
22414022-5	2012	CaMKII blockage and Akt inhibition were performed by KN-93/CaMKIIalpha siRNA and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	0-6
22435954-9	2012	The beneficial effects of TK were blocked by pretreatment with icatibant and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	kallikrein 1	Homo sapiens	26-28
22469516-3	2012	BBR (0.1-10 nM) led to increasing insulin receptor expression, Akt phosphorylation and enhanced oxidant-sensitive Nrf2/HO-1 induction, which were blocked by a PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	insulin receptor	Mus musculus	34-50
22469516-3	2012	BBR (0.1-10 nM) led to increasing insulin receptor expression, Akt phosphorylation and enhanced oxidant-sensitive Nrf2/HO-1 induction, which were blocked by a PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	thymoma viral proto-oncogene 1	Mus musculus	63-66
22469516-3	2012	BBR (0.1-10 nM) led to increasing insulin receptor expression, Akt phosphorylation and enhanced oxidant-sensitive Nrf2/HO-1 induction, which were blocked by a PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
22469516-3	2012	BBR (0.1-10 nM) led to increasing insulin receptor expression, Akt phosphorylation and enhanced oxidant-sensitive Nrf2/HO-1 induction, which were blocked by a PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	heme oxygenase 1	Mus musculus	119-123
22224457-5	2012	EXPERIMENTAL APPROACH: Depressor responses to renin microinjected into the NTS of Wistar-Kyoto rats were elicited in the absence and presence of the endothelial nitric oxide synthase (eNOS)-specific inhibitor, N(5)-(-iminoethyl)-L-ornithine, Akt inhibitor IV and LY294002, a PI3K inhibitor and GP antagonist-2A [G(q) inhibitor].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	263-271	renin	Rattus norvegicus	46-51
22537549-7	2012	PD98059 and LY294002 neutralize the preventive effects of IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	insulin-like growth factor 1	Rattus norvegicus	58-63
22664423-6	2012	SAL enhanced Akt phosphorylation in PC12 cells, and the protective effects of SAL against MPP(+)-induced apoptosis were abolished by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
22611165-14	2012	Furthermore, while the phosphoinositide-3-kinase (PI3K)/AKT signaling pathway did not alter GJA1 phosphorylation, treatment with PI3K/AKT inhibitor LY294002 significantly (P=0.024) inhibited the EGF-stimulated increase in GJA1 total protein levels at 24 h. Immunolocalization indicated that loss of PI3K/AKT signaling was associated with increased cytosolic localization of Cx43 in this cell line.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Homo sapiens	134-137
22611165-14	2012	Furthermore, while the phosphoinositide-3-kinase (PI3K)/AKT signaling pathway did not alter GJA1 phosphorylation, treatment with PI3K/AKT inhibitor LY294002 significantly (P=0.024) inhibited the EGF-stimulated increase in GJA1 total protein levels at 24 h. Immunolocalization indicated that loss of PI3K/AKT signaling was associated with increased cytosolic localization of Cx43 in this cell line.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	epidermal growth factor	Homo sapiens	195-198
22611165-14	2012	Furthermore, while the phosphoinositide-3-kinase (PI3K)/AKT signaling pathway did not alter GJA1 phosphorylation, treatment with PI3K/AKT inhibitor LY294002 significantly (P=0.024) inhibited the EGF-stimulated increase in GJA1 total protein levels at 24 h. Immunolocalization indicated that loss of PI3K/AKT signaling was associated with increased cytosolic localization of Cx43 in this cell line.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	gap junction protein alpha 1	Homo sapiens	222-226
22611165-14	2012	Furthermore, while the phosphoinositide-3-kinase (PI3K)/AKT signaling pathway did not alter GJA1 phosphorylation, treatment with PI3K/AKT inhibitor LY294002 significantly (P=0.024) inhibited the EGF-stimulated increase in GJA1 total protein levels at 24 h. Immunolocalization indicated that loss of PI3K/AKT signaling was associated with increased cytosolic localization of Cx43 in this cell line.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Homo sapiens	134-137
22611165-14	2012	Furthermore, while the phosphoinositide-3-kinase (PI3K)/AKT signaling pathway did not alter GJA1 phosphorylation, treatment with PI3K/AKT inhibitor LY294002 significantly (P=0.024) inhibited the EGF-stimulated increase in GJA1 total protein levels at 24 h. Immunolocalization indicated that loss of PI3K/AKT signaling was associated with increased cytosolic localization of Cx43 in this cell line.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	gap junction protein alpha 1	Homo sapiens	374-378
22371121-9	2012	However, pretreatment with LY294002 significantly diminished IL-1beta-induced proliferation, migration, adhesion, and VEGF-A production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	vascular endothelial growth factor A	Homo sapiens	118-124
22591694-4	2012	Stimulation of DCs with CCR7 ligands induced phosphorylation of MAPK family members and of Akt, but only a specific PI3K inhibitor, LY294002, not inhibitors of ERK, JNK, or p38, decreased IL-23p19 transcription and IL-23 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	chemokine (C-C motif) receptor 7	Mus musculus	24-28
22707636-6	2012	Inhibition of PI3K/AKT by LY294002 reactivated GSK-3beta and suppressed the TNF-alpha-induced EMT of RCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	19-22
22015454-7	2012	However, TGFbeta1 increased calponin and alpha-SMA expression was inhibited by IC87114 and LY294002 in all three groups.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	transforming growth factor beta 1	Homo sapiens	9-17
22015454-8	2012	IC87114, TGX221, and LY294002 reduced TGFbeta1 induced IL-6 release in a dose related manner in all groups of ASM cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	transforming growth factor beta 1	Homo sapiens	38-46
22015454-8	2012	IC87114, TGX221, and LY294002 reduced TGFbeta1 induced IL-6 release in a dose related manner in all groups of ASM cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	interleukin 6	Homo sapiens	55-59
22614123-6	2012	Treatment with 25 microM LY294002, a selective inhibitor of PI3K, for 20 min before H2O2 preconditioning blocked not only H2O2 preconditioning-induced HO-1 induction, but also the protective effect of H2O2 preconditioning against cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	heme oxygenase 1	Rattus norvegicus	151-155
22843181-9	2012	However, the PI3K/Akt pathway inhibitor, LY294002, abrogated the protective effect of Ang1 preconditioning.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	18-21
22843181-9	2012	However, the PI3K/Akt pathway inhibitor, LY294002, abrogated the protective effect of Ang1 preconditioning.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	angiopoietin 1	Homo sapiens	86-90
22707636-6	2012	Inhibition of PI3K/AKT by LY294002 reactivated GSK-3beta and suppressed the TNF-alpha-induced EMT of RCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	glycogen synthase kinase 3 beta	Homo sapiens	47-56
22707636-6	2012	Inhibition of PI3K/AKT by LY294002 reactivated GSK-3beta and suppressed the TNF-alpha-induced EMT of RCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	tumor necrosis factor	Homo sapiens	76-85
22954111-7	2012	CONCLUSION: LY294002 could reverse the adriamycin-induced epithelial-mesenchymal transition in human breast carcinoma cells by regulating the expressions of Snail and E-cadherin through suppressing PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	snail family transcriptional repressor 1	Homo sapiens	157-162
22683349-7	2012	However, when blocking the PI3K/Akt pathway with LY294002, the neuroprotective effect of guanosine was abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	32-35
22641480-10	2012	The Akt inhibitor             LY294002 did not mimic the effect of UA on caspase-8 and -9, but inhibited the             viability of MIA PaCa-2 cells to some extent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	4-7
22954111-7	2012	CONCLUSION: LY294002 could reverse the adriamycin-induced epithelial-mesenchymal transition in human breast carcinoma cells by regulating the expressions of Snail and E-cadherin through suppressing PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	cadherin 1	Homo sapiens	167-177
22954111-7	2012	CONCLUSION: LY294002 could reverse the adriamycin-induced epithelial-mesenchymal transition in human breast carcinoma cells by regulating the expressions of Snail and E-cadherin through suppressing PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Homo sapiens	203-206
22609091-6	2012	Inhibition of the PI3K/Akt and ERK1/2 pathways by specific inhibitors, LY294002 and U0126, respectively, partially reduce the protective effect of bFGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
22165914-6	2012	Importantly, the protective effects of HPC were abolished by a neutralizing antibody against VEGF-A and the phosphoinositol 3-kinase inhibitor LY294002, demonstrating the importance of VEGF-A and Akt in hypoxia-induced ASC survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	vascular endothelial growth factor A	Homo sapiens	185-191
22609091-6	2012	Inhibition of the PI3K/Akt and ERK1/2 pathways by specific inhibitors, LY294002 and U0126, respectively, partially reduce the protective effect of bFGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	mitogen activated protein kinase 3	Rattus norvegicus	31-37
22609091-6	2012	Inhibition of the PI3K/Akt and ERK1/2 pathways by specific inhibitors, LY294002 and U0126, respectively, partially reduce the protective effect of bFGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	fibroblast growth factor 2	Rattus norvegicus	147-151
22799881-6	2012	RESULTS: The activation of the ER by E2 is unable to induce the cell cycle progression when the phosphatidyl inositol-3 kinase (PI3K)/Akt signaling is blocked by a chemical inhibitor (LY 294002) or by shRNA targeting Akt1 and Akt2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-193	AKT serine/threonine kinase 1	Homo sapiens	134-137
22430940-9	2012	Inhibition of phosphatidylinositol 3-kinase using LY294002 did not affect ALDH2-conferred protection against ER stress, although LY294002 reversed the antiapoptotic action of ALDH2 associated with p47(phox) NADPH oxidase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	175-180
22430940-9	2012	Inhibition of phosphatidylinositol 3-kinase using LY294002 did not affect ALDH2-conferred protection against ER stress, although LY294002 reversed the antiapoptotic action of ALDH2 associated with p47(phox) NADPH oxidase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	197-200
22534171-8	2012	RESULTS: We show that PI3K inhibitors LY294002, wortmannin and A6730 significantly inhibited TF promoter activity, and reduced TF mRNA and protein levels due to the inhibition of Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	coagulation factor III, tissue factor	Homo sapiens	93-95
22525723-9	2012	Simultaneously targeting the two pathways by using U0126 and LY294002 inhibitors or using CCX733, a selective CXCR7 antagonist drastically reduced CXCR7-induced EMT process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	atypical chemokine receptor 3	Homo sapiens	147-152
22534171-8	2012	RESULTS: We show that PI3K inhibitors LY294002, wortmannin and A6730 significantly inhibited TF promoter activity, and reduced TF mRNA and protein levels due to the inhibition of Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	coagulation factor III, tissue factor	Homo sapiens	127-129
22534171-8	2012	RESULTS: We show that PI3K inhibitors LY294002, wortmannin and A6730 significantly inhibited TF promoter activity, and reduced TF mRNA and protein levels due to the inhibition of Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	179-182
22763741-7	2012	Moreover, the GEE8080-induced expressions of Nrf2 and HO-1 were attenuated by treatments of SB202190 (a p38 specific inhibitor) and LY294002 (an Akt specific inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
22619175-8	2012	In addition, the blockade of PI3K signaling by a small molecule inhibitor, LY294002, increased cytoplasmic phospho-Mst1-Thr-183 without having a significant effect on nuclear phospho-Mst1-Thr-120.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	macrophage stimulating 1	Homo sapiens	115-119
22561298-6	2012	Furthermore, the VCAM-1 induction was significantly prevented by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002, whereas it was accelerated by the ERK inhibitor, U-0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-125	vascular cell adhesion molecule 1	Mus musculus	17-23
22517768-10	2012	However, inhibition of either Src tyrosine kinase signaling by PP2, Rho kinase signaling by Y27632, or phosphatidylinositol 3 (PI3) kinase signaling by LY294002 prevented 2fLI-induced COX-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
22705730-10	2012	Atorvastatin (10 mumol/L) significantly increased the levels of phosphorylated PDK1, Akt and mTOR in the cortical neurons, which were prevented by LY294002 (30 mumol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	pyruvate dehydrogenase kinase 1	Homo sapiens	79-83
22705730-10	2012	Atorvastatin (10 mumol/L) significantly increased the levels of phosphorylated PDK1, Akt and mTOR in the cortical neurons, which were prevented by LY294002 (30 mumol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	AKT serine/threonine kinase 1	Homo sapiens	85-88
22705730-10	2012	Atorvastatin (10 mumol/L) significantly increased the levels of phosphorylated PDK1, Akt and mTOR in the cortical neurons, which were prevented by LY294002 (30 mumol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	mechanistic target of rapamycin kinase	Homo sapiens	93-97
22705730-12	2012	In addition, atorvastatin (10 mumol/L) significantly increased the phosphorylated GSK-3beta level in the cortical neurons, which was prevented by both LY294002 and tricribine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	glycogen synthase kinase 3 beta	Homo sapiens	82-91
22716253-4	2012	LY294002 (PI3K inhibitor) can reverse alpha-NF-induced ERK, Akt, Smad-3 activation, pro-collagen synthesis and alpha-NF-suppressed AP-1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 1	Homo sapiens	55-58
22575459-7	2012	Moreover, inhibition of PI3K with LY294002 abolished the effect of IGF-1 on the phosphorylation of PDK and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	insulin-like growth factor 1	Rattus norvegicus	67-72
22575459-7	2012	Moreover, inhibition of PI3K with LY294002 abolished the effect of IGF-1 on the phosphorylation of PDK and AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
22610073-11	2012	Further, IL-8-promoted migration and invasion could be abolished by either the application of the phosphoinositide-3-kinase inhibitor LY294002 or the knock down of AKT expression by using small-interfering RNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
22716253-4	2012	LY294002 (PI3K inhibitor) can reverse alpha-NF-induced ERK, Akt, Smad-3 activation, pro-collagen synthesis and alpha-NF-suppressed AP-1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	60-63
22716253-4	2012	LY294002 (PI3K inhibitor) can reverse alpha-NF-induced ERK, Akt, Smad-3 activation, pro-collagen synthesis and alpha-NF-suppressed AP-1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	SMAD family member 3	Homo sapiens	65-71
22561121-6	2012	SP600125, PD98059, and LY294002 inhibited the induction of at least CCL2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	C-C motif chemokine ligand 2	Homo sapiens	68-72
22318920-8	2012	This retained expression of Bcl-xL is inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	BCL2-like 1	Mus musculus	28-34
22318920-8	2012	This retained expression of Bcl-xL is inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	55-84
22441145-3	2012	The effect of Ras/MEK/ERK pathway on TGF-beta-mediated Lefty up-regulation was tested by adding K-ras small interfering RNA, MEK inhibitor U0126, or extracellular signal-regulated kinase (ERK) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	transforming growth factor beta 1	Homo sapiens	37-45
22665040-6	2012	LY294002 but not wortmannin, which are phosphatidylinositol 3-kinase inhibitors, also diminished the expression of progranulin in both cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	granulin precursor	Homo sapiens	115-126
22016349-5	2012	Inhibition of Akt phosphorylation  by the phosphatidylinositol 3-kinase inhibitor LY294002 resulted in reduction  of PSA expression in LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	14-17
22016349-5	2012	Inhibition of Akt phosphorylation  by the phosphatidylinositol 3-kinase inhibitor LY294002 resulted in reduction  of PSA expression in LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	kallikrein related peptidase 3	Homo sapiens	117-120
22441145-3	2012	The effect of Ras/MEK/ERK pathway on TGF-beta-mediated Lefty up-regulation was tested by adding K-ras small interfering RNA, MEK inhibitor U0126, or extracellular signal-regulated kinase (ERK) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	mitogen-activated protein kinase 1	Homo sapiens	188-191
22552808-6	2012	FoxO1 and FoxO3 phosphorylation were prevented by the PI3 kinase (PI3K) inhibitor LY294002 while inhibitors of ERK1/2 (PD98059) or p38MAPK (SB203580) were ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	forkhead box O1	Homo sapiens	0-5
22459175-5	2012	However, MMP-9 expression at both transcriptional and translational levels was attenuated by treatment with SP600125, LY294002, or SH-5, not by U0126 and SB202190, suggesting that JNK1/2 and PI3-K/Akt participate in MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	matrix metallopeptidase 9	Homo sapiens	9-14
22459175-6	2012	Moreover, NF-kappaB phosphorylation and nuclear translocation was especially noted at the leading edge, which was attenuated by treatment with SP600125 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	nuclear factor kappa B subunit 1	Homo sapiens	10-19
22552808-6	2012	FoxO1 and FoxO3 phosphorylation were prevented by the PI3 kinase (PI3K) inhibitor LY294002 while inhibitors of ERK1/2 (PD98059) or p38MAPK (SB203580) were ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	forkhead box O3	Homo sapiens	10-15
22561873-7	2012	These changes, which occur only after CSE stimulation, were prevented and reversed by anisodamine, and CSE-induced cyclin D1 expression was significantly inhibited by anisodamine and the specific inhibitor U0126, BAY11-7082 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	228-236	cyclin D1	Rattus norvegicus	115-124
22552808-7	2012	LY294002 moreover prevented thrombin-stimulated SMC mitogenesis and proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	coagulation factor II, thrombin	Homo sapiens	28-36
22552808-11	2012	LY294002 restored p21CIP1 and p27kip1 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	18-25
22552808-11	2012	LY294002 restored p21CIP1 and p27kip1 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	30-37
22575563-10	2012	Wortmannin or LY294002, which attenuated FGF-2-induced phosphorylation of Akt and GSK3beta, had no effect on FGF-2-induced phosphorylation of p44/p42 MAP kinase or SAPK/JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	fibroblast growth factor 2	Rattus norvegicus	41-46
22575563-10	2012	Wortmannin or LY294002, which attenuated FGF-2-induced phosphorylation of Akt and GSK3beta, had no effect on FGF-2-induced phosphorylation of p44/p42 MAP kinase or SAPK/JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
22575563-7	2012	FGF-2-stimulated release of GDNF was suppressed by wortmannin (a phosphatidylinositol 3 (PI3)-kinase inhibitor) or LY294002 (another PI3-kinase inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	fibroblast growth factor 2	Rattus norvegicus	0-5
22575563-10	2012	Wortmannin or LY294002, which attenuated FGF-2-induced phosphorylation of Akt and GSK3beta, had no effect on FGF-2-induced phosphorylation of p44/p42 MAP kinase or SAPK/JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	glycogen synthase kinase 3 beta	Rattus norvegicus	82-90
22575563-7	2012	FGF-2-stimulated release of GDNF was suppressed by wortmannin (a phosphatidylinositol 3 (PI3)-kinase inhibitor) or LY294002 (another PI3-kinase inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	glial cell derived neurotrophic factor	Rattus norvegicus	28-32
22742729-8	2012	NGF-evoked CGRP up-regulation is also blocked by inhibition of the MEK/ERK pathway with specific MEK inhibitors U0126 and PD98059, but not by inhibition of the PI3K/Akt pathway with inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	192-200	calcitonin-related polypeptide alpha	Rattus norvegicus	11-15
22263786-4	2012	Moreover, the synergetic effects were observed when genistein was replaced by PI3K/Akt-pathway inhibitor (LY-294002) or NF-kappaB inhibitor (BAY11-7082).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-115	AKT serine/threonine kinase 1	Homo sapiens	83-86
22634009-6	2012	This dissociation was prevented by treatment with LY294002, a PI3K inhibitor, indicating that insulin activation of the PI3K pathway leads to dissociation of IRS-2 from USP7 and IRS-2 degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	insulin	Cricetulus griseus	94-101
22634009-6	2012	This dissociation was prevented by treatment with LY294002, a PI3K inhibitor, indicating that insulin activation of the PI3K pathway leads to dissociation of IRS-2 from USP7 and IRS-2 degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	insulin receptor substrate 2	Cricetulus griseus	158-163
22634009-6	2012	This dissociation was prevented by treatment with LY294002, a PI3K inhibitor, indicating that insulin activation of the PI3K pathway leads to dissociation of IRS-2 from USP7 and IRS-2 degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	ubiquitin carboxyl-terminal hydrolase 7	Cricetulus griseus	169-173
22634009-6	2012	This dissociation was prevented by treatment with LY294002, a PI3K inhibitor, indicating that insulin activation of the PI3K pathway leads to dissociation of IRS-2 from USP7 and IRS-2 degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	insulin receptor substrate 2	Cricetulus griseus	178-183
22618230-7	2012	Inhibition of PI3K/Akt pathway by LY294002 reversed the proliferation and cell cycle progression of MDA-MB-231 and MCF-7 cells induced by IL-7delta5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	19-22
22510476-6	2012	However, LY294002, an inhibitor of the PI3K/Akt signaling pathway, diminished this effect, suggesting that enhanced expression of miR-126 increased the sensitivity of NSCLC cells to anticancer agents through negative regulation of a VEGF/PI3K/Akt/MRP1 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	44-47
22510476-6	2012	However, LY294002, an inhibitor of the PI3K/Akt signaling pathway, diminished this effect, suggesting that enhanced expression of miR-126 increased the sensitivity of NSCLC cells to anticancer agents through negative regulation of a VEGF/PI3K/Akt/MRP1 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	microRNA 126	Homo sapiens	130-137
22510476-6	2012	However, LY294002, an inhibitor of the PI3K/Akt signaling pathway, diminished this effect, suggesting that enhanced expression of miR-126 increased the sensitivity of NSCLC cells to anticancer agents through negative regulation of a VEGF/PI3K/Akt/MRP1 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	vascular endothelial growth factor A	Homo sapiens	233-237
22510476-6	2012	However, LY294002, an inhibitor of the PI3K/Akt signaling pathway, diminished this effect, suggesting that enhanced expression of miR-126 increased the sensitivity of NSCLC cells to anticancer agents through negative regulation of a VEGF/PI3K/Akt/MRP1 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	243-246
22510476-6	2012	However, LY294002, an inhibitor of the PI3K/Akt signaling pathway, diminished this effect, suggesting that enhanced expression of miR-126 increased the sensitivity of NSCLC cells to anticancer agents through negative regulation of a VEGF/PI3K/Akt/MRP1 signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	ATP binding cassette subfamily C member 1	Homo sapiens	247-251
22461520-2	2012	In this study, we report that the treatment of LNCaP cells with epidermal growth factor (EGF) in the presence of LY294002, an inhibitor of the phosphoinositol 3"-kinase (PI3K)-AKT pathway, induced an increase of levels and activity of ErbB2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Homo sapiens	176-179
22694815-10	2012	LY294002 could abolish the AKT1 activation and attenuate the protective effect of H 2S on hepatocytes A/R and hepatic I/R injuries.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	27-31
22461520-0	2012	EGF promotes neuroendocrine-like differentiation of prostate cancer cells in the presence of LY294002 through increased ErbB2 expression independent of the phosphatidylinositol 3-kinase-AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	epidermal growth factor	Homo sapiens	0-3
22461520-2	2012	In this study, we report that the treatment of LNCaP cells with epidermal growth factor (EGF) in the presence of LY294002, an inhibitor of the phosphoinositol 3"-kinase (PI3K)-AKT pathway, induced an increase of levels and activity of ErbB2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	erb-b2 receptor tyrosine kinase 2	Homo sapiens	235-240
22461520-0	2012	EGF promotes neuroendocrine-like differentiation of prostate cancer cells in the presence of LY294002 through increased ErbB2 expression independent of the phosphatidylinositol 3-kinase-AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	erb-b2 receptor tyrosine kinase 2	Homo sapiens	120-125
22461520-4	2012	When we treated with wortmannin, another PI3K inhibitor, or we knocked down PI3K or AKT isoforms in the presence of EGF, ErbB2 up-regulation was not observed, suggesting that the increase of ErbB2 induced by EGF plus LY294002 is not mediated by the PI3K-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	AKT serine/threonine kinase 1	Homo sapiens	84-87
22461520-2	2012	In this study, we report that the treatment of LNCaP cells with epidermal growth factor (EGF) in the presence of LY294002, an inhibitor of the phosphoinositol 3"-kinase (PI3K)-AKT pathway, induced an increase of levels and activity of ErbB2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	epidermal growth factor	Homo sapiens	64-87
22461520-2	2012	In this study, we report that the treatment of LNCaP cells with epidermal growth factor (EGF) in the presence of LY294002, an inhibitor of the phosphoinositol 3"-kinase (PI3K)-AKT pathway, induced an increase of levels and activity of ErbB2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	epidermal growth factor	Homo sapiens	89-92
22461520-4	2012	When we treated with wortmannin, another PI3K inhibitor, or we knocked down PI3K or AKT isoforms in the presence of EGF, ErbB2 up-regulation was not observed, suggesting that the increase of ErbB2 induced by EGF plus LY294002 is not mediated by the PI3K-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	erb-b2 receptor tyrosine kinase 2	Homo sapiens	191-196
22426850-10	2012	In addition, LY294002, a PI3K/Akt inhibitor,             sensitized ZR-75-1 breast cancer cells to cerulenin-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	30-33
22620683-10	2012	However, inhibition of Akt by PI3K/AKT antagonist LY294002 only slightly reversed the anti-apoptosis effect of LA and mildly decreased the gene expression level of Pdx1 (P &gt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	pancreas/duodenum homeobox protein 1	Mesocricetus auratus	164-168
22394107-13	2012	LY294002 treatment abolished the preferential survival of CD133(high) cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	prominin 1	Homo sapiens	58-63
22249904-6	2012	The IGF-1-induced osteoblast proliferation was mediated via both MAPK and Akt pathways because the IGF-1-mediated cell proliferation was blocked by U0126, an MEK/MAPK inhibitor, or LY294002, a PI3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	insulin-like growth factor 1	Mus musculus	4-9
22249904-6	2012	The IGF-1-induced osteoblast proliferation was mediated via both MAPK and Akt pathways because the IGF-1-mediated cell proliferation was blocked by U0126, an MEK/MAPK inhibitor, or LY294002, a PI3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	thymoma viral proto-oncogene 1	Mus musculus	74-77
22249904-6	2012	The IGF-1-induced osteoblast proliferation was mediated via both MAPK and Akt pathways because the IGF-1-mediated cell proliferation was blocked by U0126, an MEK/MAPK inhibitor, or LY294002, a PI3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	insulin-like growth factor 1	Mus musculus	99-104
22426488-9	2012	The insulin-induced mitogenic and anti-apoptotic effects in EC cells were blocked when cells were pre-incubated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	insulin	Homo sapiens	4-11
22426488-11	2012	The insulin-induced Akt activation was inhibited by LY294002 in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	insulin	Homo sapiens	4-11
22426488-11	2012	The insulin-induced Akt activation was inhibited by LY294002 in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	20-23
22943759-9	2012	LY294002, the specific inhibitor of PI3K, could suppress the activation of PI3K/Akt and the induced expression of HO-1 in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	80-83
21826653-6	2012	Modulation of SREBP-1 protein level by T(3) was dependent on MAPK/ERK, PI3K/Akt/mTOR-C1 pathway activation since the MEK inhibitor PD98059 or the PI3K inhibitor LY294002 abolished the stimulatory effect of T(3) .	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	sterol regulatory element binding transcription factor 1	Homo sapiens	14-21
22350758-6	2012	In particular, the combination of LY294002 or PP2 with SB431542 blocked NRG1-mediated CTGF expression in HTSF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	neuregulin 1	Homo sapiens	72-76
22350758-6	2012	In particular, the combination of LY294002 or PP2 with SB431542 blocked NRG1-mediated CTGF expression in HTSF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	cellular communication network factor 2	Homo sapiens	86-90
22426819-0	2012	The PI3K/Akt inhibitor LY294002 reverses BCRP-mediated drug resistance             without affecting BCRP translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	9-12
22426819-0	2012	The PI3K/Akt inhibitor LY294002 reverses BCRP-mediated drug resistance             without affecting BCRP translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	41-45
22426819-5	2012	In this study, we assessed the effects of PI3K inhibitors,             LY294002 and wortmannin, on BCRP-mediated anticancer drug resistance of human             cancer MCF-7 and A431 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	99-103
22426819-6	2012	LY294002, but not wortmannin, reversed the BCRP-mediated             SN-38 and topotecan resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	43-47
22426819-7	2012	LY294002 treatment did not affect total or cell             surface BCRP levels as determined by western blotting and flow cytometry but blocked             BCRP-mediated topotecan efflux in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	157-161
22426819-11	2012	Taken together, these results suggest that LY294002 inhibits             BCRP-mediated drug transport not by BCRP translocation through the PI3K/Akt signal             but putatively as a competitive inhibitor in a major subset of cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	73-77
22426819-11	2012	Taken together, these results suggest that LY294002 inhibits             BCRP-mediated drug transport not by BCRP translocation through the PI3K/Akt signal             but putatively as a competitive inhibitor in a major subset of cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	145-148
22528394-6	2012	Importantly, the enhanced glucose uptake induced by NYGGF4 silencing could be abrogated by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	phosphotyrosine interaction domain containing 1	Mus musculus	52-58
22465692-9	2012	Changes in the Ca transient amplitude and tau were prevented by the PI3K inhibitors Wortmannin (100nmol/L) and LY294002 (10mumol/L) and the Akt inhibitor V (20mumol/L) indicating regulation through PI3K signal transduction and Akt activation which was confirmed by western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	thymoma viral proto-oncogene 1	Mus musculus	227-230
22822374-5	2012	Inhibition of PI3K/Akt/eNOS by LY294002 or L-NAME suppressed X-13-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	19-22
22943759-9	2012	LY294002, the specific inhibitor of PI3K, could suppress the activation of PI3K/Akt and the induced expression of HO-1 in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heme oxygenase 1	Homo sapiens	114-118
21996746-10	2012	LY294002 and GDC-0941, inhibitors of PI3K, or Rapamycin, an inhibitor of PI3K downstream target mTOR, can reverse the effects of Gab2 on migration and invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GRB2 associated binding protein 2	Homo sapiens	129-133
22182447-9	2012	However, LY294002 substantially restored or increased cell surface E-cadherin and beta-catenin in all EGF-treated cell lines, in concordance with the inhibition of cell morphological changes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	cadherin 1	Homo sapiens	67-77
22182447-9	2012	However, LY294002 substantially restored or increased cell surface E-cadherin and beta-catenin in all EGF-treated cell lines, in concordance with the inhibition of cell morphological changes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	catenin beta 1	Homo sapiens	82-94
22182447-10	2012	Moreover, LY294002 significantly blocked EGF-driven cell invasion, correlating with the elevation of membranous E-cadherin and beta-catenin levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	cadherin 1	Homo sapiens	112-122
22182447-10	2012	Moreover, LY294002 significantly blocked EGF-driven cell invasion, correlating with the elevation of membranous E-cadherin and beta-catenin levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	catenin beta 1	Homo sapiens	127-139
22493444-5	2012	The inhibition of PI3K by PIK-93, LY294002, or wortmannin decreased carbachol-induced translocation of TRPC6 to the plasma membrane and carbachol-induced net Ca(2+) entry into T6.11 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	103-108
22490886-7	2012	The phosphorylation of Akt and PRAS40 induced by IGF-1 (100ng/ml) was inhibited by the phosphatidylinositide 3-kinase (PI3K) specific inhibitor LY294002 (50muM), while no inhibitory effect was observed for a MAPK kinase pathway specific inhibitor PD98059 nor a p38 MAPK inhibitor PD169316, suggesting that the phosphorylation of PRAS40 induced by IGF-1 is mediated by the PI3K pathway in PC12 cells and primary cultured neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
22490886-7	2012	The phosphorylation of Akt and PRAS40 induced by IGF-1 (100ng/ml) was inhibited by the phosphatidylinositide 3-kinase (PI3K) specific inhibitor LY294002 (50muM), while no inhibitory effect was observed for a MAPK kinase pathway specific inhibitor PD98059 nor a p38 MAPK inhibitor PD169316, suggesting that the phosphorylation of PRAS40 induced by IGF-1 is mediated by the PI3K pathway in PC12 cells and primary cultured neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	AKT1 substrate 1	Rattus norvegicus	31-37
22490886-7	2012	The phosphorylation of Akt and PRAS40 induced by IGF-1 (100ng/ml) was inhibited by the phosphatidylinositide 3-kinase (PI3K) specific inhibitor LY294002 (50muM), while no inhibitory effect was observed for a MAPK kinase pathway specific inhibitor PD98059 nor a p38 MAPK inhibitor PD169316, suggesting that the phosphorylation of PRAS40 induced by IGF-1 is mediated by the PI3K pathway in PC12 cells and primary cultured neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	insulin-like growth factor 1	Rattus norvegicus	49-54
22490886-7	2012	The phosphorylation of Akt and PRAS40 induced by IGF-1 (100ng/ml) was inhibited by the phosphatidylinositide 3-kinase (PI3K) specific inhibitor LY294002 (50muM), while no inhibitory effect was observed for a MAPK kinase pathway specific inhibitor PD98059 nor a p38 MAPK inhibitor PD169316, suggesting that the phosphorylation of PRAS40 induced by IGF-1 is mediated by the PI3K pathway in PC12 cells and primary cultured neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	87-117
22490886-7	2012	The phosphorylation of Akt and PRAS40 induced by IGF-1 (100ng/ml) was inhibited by the phosphatidylinositide 3-kinase (PI3K) specific inhibitor LY294002 (50muM), while no inhibitory effect was observed for a MAPK kinase pathway specific inhibitor PD98059 nor a p38 MAPK inhibitor PD169316, suggesting that the phosphorylation of PRAS40 induced by IGF-1 is mediated by the PI3K pathway in PC12 cells and primary cultured neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	AKT1 substrate 1	Rattus norvegicus	329-335
22490886-7	2012	The phosphorylation of Akt and PRAS40 induced by IGF-1 (100ng/ml) was inhibited by the phosphatidylinositide 3-kinase (PI3K) specific inhibitor LY294002 (50muM), while no inhibitory effect was observed for a MAPK kinase pathway specific inhibitor PD98059 nor a p38 MAPK inhibitor PD169316, suggesting that the phosphorylation of PRAS40 induced by IGF-1 is mediated by the PI3K pathway in PC12 cells and primary cultured neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	insulin-like growth factor 1	Rattus norvegicus	347-352
22354782-5	2012	The PI3K inhibitors LY-294002 and wortmannin partially inhibited the PRL release induced by E(2)-BSA, TRH, and E(2)/TRH and totally inhibited the PRL levels stimulated by E(2)-BSA/TRH, suggesting that the mER mediated the cooperative effect of E(2) on TRH-induced PRL release through the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	prolactin	Rattus norvegicus	69-72
22387113-7	2012	The FKN-induced depressor and bradycardic responses were inhibited by pretreatment with a phosphoinositide 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	C-X3-C motif chemokine ligand 1	Rattus norvegicus	4-7
22402346-9	2012	Blocking Shh or phosphoinositide 3-kinases (PI3-K)/AKT signaling pathway with cyclopamine or LY294002 decreased the survival rate of astrocytes, induced cell apoptosis, upregulated the expression of Bax, and downregulated the expression of Bcl-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	sonic hedgehog signaling molecule	Rattus norvegicus	9-12
22402346-9	2012	Blocking Shh or phosphoinositide 3-kinases (PI3-K)/AKT signaling pathway with cyclopamine or LY294002 decreased the survival rate of astrocytes, induced cell apoptosis, upregulated the expression of Bax, and downregulated the expression of Bcl-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	16-42
22402346-9	2012	Blocking Shh or phosphoinositide 3-kinases (PI3-K)/AKT signaling pathway with cyclopamine or LY294002 decreased the survival rate of astrocytes, induced cell apoptosis, upregulated the expression of Bax, and downregulated the expression of Bcl-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Rattus norvegicus	51-54
22237406-7	2012	The ALX/FPR2 receptor signals via modulation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways since, in our study, blocking PI3K activation with LY294002, a potent and selective PI3K inhibitor, prevented RvD1-induced cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	formyl peptide receptor 2-like	Rattus norvegicus	4-7
22237406-7	2012	The ALX/FPR2 receptor signals via modulation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways since, in our study, blocking PI3K activation with LY294002, a potent and selective PI3K inhibitor, prevented RvD1-induced cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	formyl peptide receptor 2	Rattus norvegicus	8-12
22237406-7	2012	The ALX/FPR2 receptor signals via modulation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways since, in our study, blocking PI3K activation with LY294002, a potent and selective PI3K inhibitor, prevented RvD1-induced cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	AKT serine/threonine kinase 1	Rattus norvegicus	89-92
22354782-5	2012	The PI3K inhibitors LY-294002 and wortmannin partially inhibited the PRL release induced by E(2)-BSA, TRH, and E(2)/TRH and totally inhibited the PRL levels stimulated by E(2)-BSA/TRH, suggesting that the mER mediated the cooperative effect of E(2) on TRH-induced PRL release through the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	thyrotropin releasing hormone	Rattus norvegicus	102-105
22354782-5	2012	The PI3K inhibitors LY-294002 and wortmannin partially inhibited the PRL release induced by E(2)-BSA, TRH, and E(2)/TRH and totally inhibited the PRL levels stimulated by E(2)-BSA/TRH, suggesting that the mER mediated the cooperative effect of E(2) on TRH-induced PRL release through the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	thyrotropin releasing hormone	Rattus norvegicus	116-119
22354782-5	2012	The PI3K inhibitors LY-294002 and wortmannin partially inhibited the PRL release induced by E(2)-BSA, TRH, and E(2)/TRH and totally inhibited the PRL levels stimulated by E(2)-BSA/TRH, suggesting that the mER mediated the cooperative effect of E(2) on TRH-induced PRL release through the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	prolactin	Rattus norvegicus	146-149
22354782-5	2012	The PI3K inhibitors LY-294002 and wortmannin partially inhibited the PRL release induced by E(2)-BSA, TRH, and E(2)/TRH and totally inhibited the PRL levels stimulated by E(2)-BSA/TRH, suggesting that the mER mediated the cooperative effect of E(2) on TRH-induced PRL release through the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	thyrotropin releasing hormone	Rattus norvegicus	116-119
22354782-5	2012	The PI3K inhibitors LY-294002 and wortmannin partially inhibited the PRL release induced by E(2)-BSA, TRH, and E(2)/TRH and totally inhibited the PRL levels stimulated by E(2)-BSA/TRH, suggesting that the mER mediated the cooperative effect of E(2) on TRH-induced PRL release through the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	thyrotropin releasing hormone	Rattus norvegicus	116-119
22354782-5	2012	The PI3K inhibitors LY-294002 and wortmannin partially inhibited the PRL release induced by E(2)-BSA, TRH, and E(2)/TRH and totally inhibited the PRL levels stimulated by E(2)-BSA/TRH, suggesting that the mER mediated the cooperative effect of E(2) on TRH-induced PRL release through the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	prolactin	Rattus norvegicus	146-149
22173835-11	2012	Pretreatment of these cells with the PI 3-Kinase inhibitor LY294002 significantly suppressed 8-CPT-2Me-cAMP-dependent p-Akt(S473) and p-Akt(S473) kinase activities, and both effects were rapamycin insensitive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	120-123
22183510-6	2012	Consistent with this, LY 294002, a PI3K inhibitor, inhibited HO-1 induction by higenamine and apoptosis induced by glucose/GOX in C6 cells was prevented by higenamine, which effect was reversed by LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-31	heme oxygenase 1	Rattus norvegicus	61-65
22183510-6	2012	Consistent with this, LY 294002, a PI3K inhibitor, inhibited HO-1 induction by higenamine and apoptosis induced by glucose/GOX in C6 cells was prevented by higenamine, which effect was reversed by LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-206	heme oxygenase 1	Rattus norvegicus	61-65
22617452-6	2012	Chemical inhibition of FGFR, NFkB, and PI3K activity by PD173074, pyrrolidine dithiocarbamate, and LY294002 respectively abrogated the FGF-2-mediated induction of Bcl2-A1 and Bcl-xL expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	fibroblast growth factor 2	Mus musculus	135-140
22617452-6	2012	Chemical inhibition of FGFR, NFkB, and PI3K activity by PD173074, pyrrolidine dithiocarbamate, and LY294002 respectively abrogated the FGF-2-mediated induction of Bcl2-A1 and Bcl-xL expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	B cell leukemia/lymphoma 2 related protein A1a	Mus musculus	163-170
22222440-6	2012	However, the protection of fucoidan on cell survival, p-Akt, the Bcl-2/Bax ratio and caspase-3 activity were abolished by pretreating with phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	139-168
22537485-7	2012	In the presence of chelerythrine (an inhibitor of PKC, 1 mg/kg) or LY294002 (an inhibitor of PI3K-Akt, 0.3 mg/kg), the protective effect of urantide was almost completely abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
22537485-8	2012	Urantide (30 microg/kg) markedly enhanced the expression of p-Akt protein during myocardial ischemia-reperfusion injury, and this enhancement was significantly attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	AKT serine/threonine kinase 1	Rattus norvegicus	62-65
22173988-2	2012	We report here that LY294002, a small molecule inhibitor of PI3K/AKT signal pathway, can inhibit proliferation and promote neuronal differentiation of MSCs after MSCs incubated with LY294002 for 6 and 12 h. RT-PCR results indicated that mRNA expression of alpha5beta1 integrin significantly increased in neuron-like cell from MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	65-68
22173988-2	2012	We report here that LY294002, a small molecule inhibitor of PI3K/AKT signal pathway, can inhibit proliferation and promote neuronal differentiation of MSCs after MSCs incubated with LY294002 for 6 and 12 h. RT-PCR results indicated that mRNA expression of alpha5beta1 integrin significantly increased in neuron-like cell from MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	AKT serine/threonine kinase 1	Homo sapiens	65-68
22577264-2	2012	Specific inhibitors of phosphatidylinositol 3-kinase (PI3K), such as wortmannin and LY294002, stimulate melanin production in mouse and in human melanoma cells, suggesting that PI3K and mammalian target of rapamycin (mTOR) might be involved in the regulation of melanogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	23-52
22577264-2	2012	Specific inhibitors of phosphatidylinositol 3-kinase (PI3K), such as wortmannin and LY294002, stimulate melanin production in mouse and in human melanoma cells, suggesting that PI3K and mammalian target of rapamycin (mTOR) might be involved in the regulation of melanogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	mechanistic target of rapamycin kinase	Homo sapiens	186-215
22577264-2	2012	Specific inhibitors of phosphatidylinositol 3-kinase (PI3K), such as wortmannin and LY294002, stimulate melanin production in mouse and in human melanoma cells, suggesting that PI3K and mammalian target of rapamycin (mTOR) might be involved in the regulation of melanogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	mechanistic target of rapamycin kinase	Homo sapiens	217-221
22426621-9	2012	Finally, cell treatment with wortmannin or LY294002 revealed that both PRL and EGF positively regulate ADRP and beta-casein synthesis through PI3-kinase signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	prolactin	Mus musculus	71-74
22426621-9	2012	Finally, cell treatment with wortmannin or LY294002 revealed that both PRL and EGF positively regulate ADRP and beta-casein synthesis through PI3-kinase signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	perilipin 2	Mus musculus	103-107
22408172-9	2012	Insulin-stimulated glucose uptake in cumulus cells is mediated through phosphatidylinositol 3-kinase signaling as shown by inhibition of insulin-stimulated glucose uptake and Akt phosphorylation with the specific phosphatidylinositol 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	254-262	insulin	Homo sapiens	0-7
22408172-9	2012	Insulin-stimulated glucose uptake in cumulus cells is mediated through phosphatidylinositol 3-kinase signaling as shown by inhibition of insulin-stimulated glucose uptake and Akt phosphorylation with the specific phosphatidylinositol 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	254-262	insulin	Homo sapiens	137-144
21780115-7	2012	Although inactivation of the PI3K/AKT pathway with LY294002 inhibited RPTC dedifferentiation, blocking the ERK1/2 pathway with U0126 did not show such an effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	34-37
22173835-11	2012	Pretreatment of these cells with the PI 3-Kinase inhibitor LY294002 significantly suppressed 8-CPT-2Me-cAMP-dependent p-Akt(S473) and p-Akt(S473) kinase activities, and both effects were rapamycin insensitive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	136-139
22147269-8	2012	Acteoside activated both ERK and PI3 K/Akt, and treatments with the specific ERK inhibitor PD98059, the PI3 K inhibitor LY294002, and the specific Nrf2 siRNA suppressed the acteoside-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	heme oxygenase 1	Rattus norvegicus	191-195
22260232-5	2012	The treatments of insulin receptor (IR)-knockdown and a phosphatidylinositol 3-kinase inhibitor (LY294002), but not an extracellular signal-regulated kinase inhibitor, induced an increase in GM1 ganglioside (GM1) levels in detergent-resistant membrane microdomains of the neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	coenzyme Q10A	Mus musculus	191-194
22260232-5	2012	The treatments of insulin receptor (IR)-knockdown and a phosphatidylinositol 3-kinase inhibitor (LY294002), but not an extracellular signal-regulated kinase inhibitor, induced an increase in GM1 ganglioside (GM1) levels in detergent-resistant membrane microdomains of the neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	coenzyme Q10A	Mus musculus	208-211
22437887-6	2012	Consistently, treatment of endothelial cells with LY294002 enhanced TNF-alpha induced TF expression to a similar extent as caffeine, and adenoviral expression of the active PI3K mutant (p110) reversed the effect of both caffeine and LY294002 on TF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	tumor necrosis factor	Homo sapiens	68-77
22437887-6	2012	Consistently, treatment of endothelial cells with LY294002 enhanced TNF-alpha induced TF expression to a similar extent as caffeine, and adenoviral expression of the active PI3K mutant (p110) reversed the effect of both caffeine and LY294002 on TF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	coagulation factor III, tissue factor	Homo sapiens	86-88
22437887-6	2012	Consistently, treatment of endothelial cells with LY294002 enhanced TNF-alpha induced TF expression to a similar extent as caffeine, and adenoviral expression of the active PI3K mutant (p110) reversed the effect of both caffeine and LY294002 on TF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	endogenous retrovirus group K member 15	Homo sapiens	186-190
22437887-6	2012	Consistently, treatment of endothelial cells with LY294002 enhanced TNF-alpha induced TF expression to a similar extent as caffeine, and adenoviral expression of the active PI3K mutant (p110) reversed the effect of both caffeine and LY294002 on TF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	endogenous retrovirus group K member 15	Homo sapiens	186-190
22437887-6	2012	Consistently, treatment of endothelial cells with LY294002 enhanced TNF-alpha induced TF expression to a similar extent as caffeine, and adenoviral expression of the active PI3K mutant (p110) reversed the effect of both caffeine and LY294002 on TF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	coagulation factor III, tissue factor	Homo sapiens	245-247
22329895-12	2012	These protective effects of urotensin II were abolished by prior inhibition of phosphatidylinositol 3-kinase/Akt by LY294002 (2-[4-morpholinyl]-8-phenyl-4H-1-benzopyran-4-one), and ERK by U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	urotensin 2	Rattus norvegicus	28-40
22422881-9	2012	The upregulation of Tim-3 could be blocked by the addition of a PI3K inhibitor, LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-89	hepatitis A virus cellular receptor 2	Homo sapiens	20-25
22487193-8	2012	Analysis of RAF-1 S259 phosphorylation, being a major mediator of the negative regulation of RAF-1 by AKT, showed decreased pRAF-1 S259 levels in LY294002 treated M13MDA435-1 hybrid cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	12-17
22487193-8	2012	Analysis of RAF-1 S259 phosphorylation, being a major mediator of the negative regulation of RAF-1 by AKT, showed decreased pRAF-1 S259 levels in LY294002 treated M13MDA435-1 hybrid cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	93-98
22487193-8	2012	Analysis of RAF-1 S259 phosphorylation, being a major mediator of the negative regulation of RAF-1 by AKT, showed decreased pRAF-1 S259 levels in LY294002 treated M13MDA435-1 hybrid cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	AKT serine/threonine kinase 1	Homo sapiens	102-105
22487193-8	2012	Analysis of RAF-1 S259 phosphorylation, being a major mediator of the negative regulation of RAF-1 by AKT, showed decreased pRAF-1 S259 levels in LY294002 treated M13MDA435-1 hybrid cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	Rab acceptor 1	Homo sapiens	124-130
22487193-10	2012	Inhibition of PI3K/AKT signalling by Ly294002 relieves the AKT mediated phosphorylation of RAF-1, thereby restoring MAPK signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	19-22
22487193-10	2012	Inhibition of PI3K/AKT signalling by Ly294002 relieves the AKT mediated phosphorylation of RAF-1, thereby restoring MAPK signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	59-62
22487193-10	2012	Inhibition of PI3K/AKT signalling by Ly294002 relieves the AKT mediated phosphorylation of RAF-1, thereby restoring MAPK signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	91-96
22564643-7	2012	Furthermore, the PI3 kinase inhibitor LY294002 was used to examine the effect of inhibiting insulin signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	insulin	Homo sapiens	92-99
22449574-4	2012	Here we demonstrate that besides inhibiting their respective target kinases, the pharmacological PI3-kinase inhibitor LY294002 and the downstream mTOR kinase inhibitor rapamycin also directly inhibit ABCG2 function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	200-205
22405892-4	2012	Furthermore, we found that testosterone significantly increased the phosphorylation level of V-akt murine thymoma viral oncogene (Akt), a key effector of the phosphoinositide 3-kinase (PI3-K)/Akt signaling pathway, while a specific PI3-K inhibitor LY294002 obviously prevented the activation of Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	248-256	thymoma viral proto-oncogene 1	Mus musculus	95-98
22405892-4	2012	Furthermore, we found that testosterone significantly increased the phosphorylation level of V-akt murine thymoma viral oncogene (Akt), a key effector of the phosphoinositide 3-kinase (PI3-K)/Akt signaling pathway, while a specific PI3-K inhibitor LY294002 obviously prevented the activation of Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	248-256	thymoma viral proto-oncogene 1	Mus musculus	130-133
22405892-5	2012	In addition, the PI3-K inhibitor LY294002 also markedly blocked the up-regulation expression of seladin-1 gene induced by testosterone at the protein and mRNA levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	24-dehydrocholesterol reductase	Mus musculus	96-105
22329895-12	2012	These protective effects of urotensin II were abolished by prior inhibition of phosphatidylinositol 3-kinase/Akt by LY294002 (2-[4-morpholinyl]-8-phenyl-4H-1-benzopyran-4-one), and ERK by U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Rattus norvegicus	109-112
22329895-12	2012	These protective effects of urotensin II were abolished by prior inhibition of phosphatidylinositol 3-kinase/Akt by LY294002 (2-[4-morpholinyl]-8-phenyl-4H-1-benzopyran-4-one), and ERK by U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-174	urotensin 2	Rattus norvegicus	28-40
22269094-5	2012	The proliferative effect of C-peptide is prevented by Src-kinase inhibitor-PP2, PI-3 kinase inhibitor-LY294002, and the ERK1/2 inhibitor-U126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	insulin	Homo sapiens	28-37
22289388-9	2012	Inhibitors of p38 alpha/beta (SB203580) and PI3K/Akt pathway (LY294002), but not that of JNK (SP600125), reduced LPS-induced LD accumulation and eliminated the activating effect of LPS on perilipin-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	AKT serine/threonine kinase 1	Homo sapiens	49-52
22245015-8	2012	Furthermore, in IL-6(-/-) mice, rIL-6 provided significant protection against TMT-induced neuronal degeneration; this effect of rIL-6 was counteracted by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	interleukin 6	Mus musculus	16-20
22354538-10	2012	Interestingly, a combination of an EGFR inhibitor with the PI3K/Akt inhibitor LY294002 led to a significant reduction of ABCG2 expression at low concentrations of the drugs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	epidermal growth factor receptor	Canis lupus familiaris	35-39
22354538-10	2012	Interestingly, a combination of an EGFR inhibitor with the PI3K/Akt inhibitor LY294002 led to a significant reduction of ABCG2 expression at low concentrations of the drugs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	ATP binding cassette subfamily G member 2	Canis lupus familiaris	121-126
22245015-8	2012	Furthermore, in IL-6(-/-) mice, rIL-6 provided significant protection against TMT-induced neuronal degeneration; this effect of rIL-6 was counteracted by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	interleukin 6	Rattus norvegicus	32-37
22309289-4	2012	The Akt-dependent phosphorylation of HBx was abrogated in the presence of the phosphatidylinositol 3-kinase inhibitor LY294002 or Akt1 gene silencing by specific siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	AKT serine/threonine kinase 1	Homo sapiens	4-7
22309289-4	2012	The Akt-dependent phosphorylation of HBx was abrogated in the presence of the phosphatidylinositol 3-kinase inhibitor LY294002 or Akt1 gene silencing by specific siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	X protein	Hepatitis B virus	37-40
22245015-8	2012	Furthermore, in IL-6(-/-) mice, rIL-6 provided significant protection against TMT-induced neuronal degeneration; this effect of rIL-6 was counteracted by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	interleukin 6	Rattus norvegicus	128-133
22526207-9	2012	The addition of PD98059, NAC, herbimycin-A, SB203580, and LY294002 markedly inhibited the arecoline-induced beta-catenin expression (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	catenin beta 1	Homo sapiens	108-120
22211238-6	2012	Furthermore, treatment with either the ERK inhibitor PD98059 or Akt inhibitor LY294002 partially reversed the CHPG"s neuroprotective effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	AKT serine/threonine kinase 1	Rattus norvegicus	64-67
21544845-9	2012	Furthermore, pretreatment with gefitinib and the pharmacological inhibitors of PI3K (LY294002) and ERK1/2 (PD98059) prevented cigarette smoke-mediated Akt and ERK1/2 phosphorylation responses, HIF-1alpha production, HIF-1 activity and MUC5AC expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Homo sapiens	151-154
21544845-9	2012	Furthermore, pretreatment with gefitinib and the pharmacological inhibitors of PI3K (LY294002) and ERK1/2 (PD98059) prevented cigarette smoke-mediated Akt and ERK1/2 phosphorylation responses, HIF-1alpha production, HIF-1 activity and MUC5AC expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	mitogen-activated protein kinase 3	Homo sapiens	159-165
21544845-9	2012	Furthermore, pretreatment with gefitinib and the pharmacological inhibitors of PI3K (LY294002) and ERK1/2 (PD98059) prevented cigarette smoke-mediated Akt and ERK1/2 phosphorylation responses, HIF-1alpha production, HIF-1 activity and MUC5AC expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	193-203
21544845-9	2012	Furthermore, pretreatment with gefitinib and the pharmacological inhibitors of PI3K (LY294002) and ERK1/2 (PD98059) prevented cigarette smoke-mediated Akt and ERK1/2 phosphorylation responses, HIF-1alpha production, HIF-1 activity and MUC5AC expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	193-198
21544845-9	2012	Furthermore, pretreatment with gefitinib and the pharmacological inhibitors of PI3K (LY294002) and ERK1/2 (PD98059) prevented cigarette smoke-mediated Akt and ERK1/2 phosphorylation responses, HIF-1alpha production, HIF-1 activity and MUC5AC expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	235-241
22227406-7	2012	PTTH-stimulated 4E-BP phosphorylation was blocked by both LY294002 and wortmannin, indicating the involvement of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	prothoracicotropic hormone	Bombyx mori	0-4
22286127-7	2012	NBP increased the phosphorylation of Akt and eNOS at serine 1177, which was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	0-3
22286127-7	2012	NBP increased the phosphorylation of Akt and eNOS at serine 1177, which was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	37-40
22286127-8	2012	NBP-stimulated nitric oxide production, which was reduced by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	0-3
22526207-12	2012	In addition, beta-catenin expression induced by arecoline is downregulated by PD98059, NAC, herbimycin-A, SB203580, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	catenin beta 1	Homo sapiens	13-25
21769475-6	2012	Furthermore, the high expression of IL-15 induced by IL-6 was down-regulated while MAPKs-ERK1/2 and PI3K-AKT signaling pathways were, respectively, blocked by PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	interleukin 15	Homo sapiens	36-41
21713404-6	2012	In addition, EMT was reversed by PI3K inhibitor LY294002 and MEK1/2 inhibitor U0126, which suggested that A549 cells under stimulation of TGF-beta1 undergo a switch into mesenchymal cells and PI3K/Akt and MAPK/Erk1/2 signaling pathways serve to regulate TGF-beta1-induced EMT of A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	transforming growth factor beta 1	Homo sapiens	138-147
21769475-6	2012	Furthermore, the high expression of IL-15 induced by IL-6 was down-regulated while MAPKs-ERK1/2 and PI3K-AKT signaling pathways were, respectively, blocked by PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	mitogen-activated protein kinase 3	Homo sapiens	89-95
22159760-9	2012	LY294002, a PI3K-Akt inhibitor, blocked the CpG ODN effect of TRAIL expression             and the sub-G1 population in serum starved cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	17-20
22466127-9	2012	Pre-incubation with PD98059, SB203580, SP600125 or LY294002, but not BIM, inhibited the formaldehyde-induced increase of TRPV1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	121-126
22139302-9	2012	In addition, blockade by the PI3K-specific inhibitor LY294002, Akt inhibitor, the NFkappaB inhibitor BAY 11-7082, the survivin inhibitor Curcumin, or the survivin inhibitor YM155 reduced the effects of Id1 transfection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	inhibitor of DNA binding 1, HLH protein	Homo sapiens	202-205
22218715-8	2012	While the inactivation of Akt by LY294002 suppressed TLR2-mediated MCP-1 induction, the inactivation of GSK3beta by LiCl potentiated TLR2-mediated MCP-1 induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	thymoma viral proto-oncogene 1	Mus musculus	26-29
22159760-9	2012	LY294002, a PI3K-Akt inhibitor, blocked the CpG ODN effect of TRAIL expression             and the sub-G1 population in serum starved cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	62-67
21971692-6	2012	It was found that EEPV increased HO-1 protein expression in RAW 264.7 cells, which was significantly inhibited by LY294002, but not PD98059, SB203580 or SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	heme oxygenase 1	Homo sapiens	33-37
21971692-7	2012	In addition, EEPV activated NF-E2-related factor (Nrf2) to move from the cytosol to the nucleus, and EEPV-induced HO-1 and activation of ARE-luciferase activity were significantly reduced by siNrf2 transfection and LY294002 but not SB203508.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	heme oxygenase 1	Homo sapiens	114-118
22390933-6	2012	Consistently, the declines of p-p38MAPK, p-CREB, COX-2 and PGI(2) were also observed after incubation with LY294002 (25mumol/L; PI3K special inhibitor) or L-NAME (50mumol/L; eNOS special inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	cAMP responsive element binding protein 1	Homo sapiens	43-47
22390933-6	2012	Consistently, the declines of p-p38MAPK, p-CREB, COX-2 and PGI(2) were also observed after incubation with LY294002 (25mumol/L; PI3K special inhibitor) or L-NAME (50mumol/L; eNOS special inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
22285490-0	2012	LY294002 inhibits TLR3/4-mediated IFN-beta production via inhibition of IRF3 activation with a PI3K-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	toll like receptor 3	Homo sapiens	18-22
22801313-7	2012	The effect of genistein on phosphorylation eNOS(Ser(1179)) level was also observed in the presence of LY294002 or NSC154020 (PI3K and AKT inhibitors).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	nitric oxide synthase 3	Homo sapiens	43-47
22801313-9	2012	Furthermore, the expression level of phosphorylation eNOS(Ser(1179)) was significantly lower in PIK3/AKT inhibitors LY294002 and NSC154020 treated cells compared with ox-LDL + genistein treated cells (all P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	nitric oxide synthase 3	Homo sapiens	53-57
22801313-9	2012	Furthermore, the expression level of phosphorylation eNOS(Ser(1179)) was significantly lower in PIK3/AKT inhibitors LY294002 and NSC154020 treated cells compared with ox-LDL + genistein treated cells (all P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	96-100
22801313-9	2012	Furthermore, the expression level of phosphorylation eNOS(Ser(1179)) was significantly lower in PIK3/AKT inhibitors LY294002 and NSC154020 treated cells compared with ox-LDL + genistein treated cells (all P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	101-104
22235114-8	2012	The role of the PI3K/Akt pathway in the regulation of repression was clarified by the use of the PI3K inhibitor, LY294002, and by transfection with Akt siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Homo sapiens	21-24
22285490-0	2012	LY294002 inhibits TLR3/4-mediated IFN-beta production via inhibition of IRF3 activation with a PI3K-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interferon beta 1	Homo sapiens	34-42
22235114-10	2012	Also, FSH abolished FoxO3a nuclear accumulation in response to LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	forkhead box O3	Homo sapiens	20-26
22285490-0	2012	LY294002 inhibits TLR3/4-mediated IFN-beta production via inhibition of IRF3 activation with a PI3K-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interferon regulatory factor 3	Homo sapiens	72-76
22285490-2	2012	In this report, we analyzed the effect of two known phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 and wortmannin on LPS- and poly(I:C)-induced IFN-beta production in peritoneal macrophages.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	interferon beta 1	Homo sapiens	154-162
22285490-3	2012	LY294002 inhibited LPS- and poly(I:C)-induced IFN-beta transcription and secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interferon beta 1	Homo sapiens	46-54
22285490-5	2012	Furthermore, IRF3 transcriptional activation and binding to IFN-beta promoter were found to be inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	interferon regulatory factor 3	Homo sapiens	13-17
22285490-5	2012	Furthermore, IRF3 transcriptional activation and binding to IFN-beta promoter were found to be inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	interferon beta 1	Homo sapiens	60-68
22285490-6	2012	Therefore, our findings demonstrate LY294002 negatively regulates LPS- and poly(I:C)-induced IFN-beta production through inhibition of IRF3 activation in a PI3K-independent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	interferon beta 1	Homo sapiens	93-101
22285490-6	2012	Therefore, our findings demonstrate LY294002 negatively regulates LPS- and poly(I:C)-induced IFN-beta production through inhibition of IRF3 activation in a PI3K-independent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	interferon regulatory factor 3	Homo sapiens	135-139
22323467-7	2012	The induction of FGF-2 by IL-1beta was completely blocked by inhibitors to NF-kappaB activation (sulfasalazine) or PI 3-kinase (LY294002), and both inhibitors greatly blocked cell proliferation of CECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	fibroblast growth factor 2	Homo sapiens	17-22
22464569-2	2012	METHODS: Burn-serum challenged cardiocytes were pretreated with insulin and inhibitors to pathway SB203580 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	insulin	Homo sapiens	64-71
22464569-8	2012	Further blocking experiments showed that LY294002, phosphatidylinositol-3-kinase (PI3K)/Akt activation inhibitor, could mitigate the protective effects of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	88-91
22464569-8	2012	Further blocking experiments showed that LY294002, phosphatidylinositol-3-kinase (PI3K)/Akt activation inhibitor, could mitigate the protective effects of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	insulin	Homo sapiens	155-162
22323467-7	2012	The induction of FGF-2 by IL-1beta was completely blocked by inhibitors to NF-kappaB activation (sulfasalazine) or PI 3-kinase (LY294002), and both inhibitors greatly blocked cell proliferation of CECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	interleukin 1 beta	Homo sapiens	26-34
22285928-5	2012	Furthermore, in BLZ-211 cells, cell cycle progression was greatly reduced after PI3-K pathway was blocked by LY294002, indicating that UCA1 affected cell cycle progression through CREB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	urothelial cancer associated 1	Homo sapiens	135-139
22424098-7	2012	A PI3K inhibitor (LY294002) attenuated CoCl(2)-induced nuclear accumulation and transcriptional activation of HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-120
22424098-8	2012	In addition, HIF-1alpha-mediated upregulation of TLR4 expression was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
22424098-8	2012	In addition, HIF-1alpha-mediated upregulation of TLR4 expression was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	toll like receptor 4	Homo sapiens	49-53
22420994-10	2012	Also, LY294002, an inhibitor of the Akt/PI3K pathway, abrogated the MA-mediated induction of IL-6 and IL-8 by 77.9 +- 6.6% and 81.4 +- 2.6%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	AKT serine/threonine kinase 1	Homo sapiens	36-39
22420994-10	2012	Also, LY294002, an inhibitor of the Akt/PI3K pathway, abrogated the MA-mediated induction of IL-6 and IL-8 by 77.9 +- 6.6% and 81.4 +- 2.6%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	interleukin 6	Homo sapiens	93-97
22420994-10	2012	Also, LY294002, an inhibitor of the Akt/PI3K pathway, abrogated the MA-mediated induction of IL-6 and IL-8 by 77.9 +- 6.6% and 81.4 +- 2.6%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
22326785-10	2012	Moreover, U0126, a mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, also inhibited LM8 cell migration, invasion, adhesion, and metastasis, as well as the mRNA expression and protein activities of MMP-1, MMP-2, MMP-9, and MT1-MMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	96-125
22326785-10	2012	Moreover, U0126, a mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, also inhibited LM8 cell migration, invasion, adhesion, and metastasis, as well as the mRNA expression and protein activities of MMP-1, MMP-2, MMP-9, and MT1-MMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	matrix metallopeptidase 13	Mus musculus	272-277
22326785-10	2012	Moreover, U0126, a mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, also inhibited LM8 cell migration, invasion, adhesion, and metastasis, as well as the mRNA expression and protein activities of MMP-1, MMP-2, MMP-9, and MT1-MMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	matrix metallopeptidase 2	Mus musculus	279-284
22326785-10	2012	Moreover, U0126, a mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, also inhibited LM8 cell migration, invasion, adhesion, and metastasis, as well as the mRNA expression and protein activities of MMP-1, MMP-2, MMP-9, and MT1-MMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	matrix metallopeptidase 9	Mus musculus	286-291
22326785-10	2012	Moreover, U0126, a mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, also inhibited LM8 cell migration, invasion, adhesion, and metastasis, as well as the mRNA expression and protein activities of MMP-1, MMP-2, MMP-9, and MT1-MMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	297-304
22155408-4	2012	Knockdown of HN1 expression by siRNA silencing leads to an increase in Akt((S473)) phosphorylation, resulting in the translocation of androgen receptor (AR) to the nucleus; these effects can be abrogated by the non-specific Akt inhibitor LY294002 but not by the ERK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	238-246	Jupiter microtubule associated homolog 1	Homo sapiens	13-16
22226932-7	2012	Ly294002, a DNA-PKcs inhibitor, boosted the capsaicin-induced cleavage of PARP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	12-20
22226932-7	2012	Ly294002, a DNA-PKcs inhibitor, boosted the capsaicin-induced cleavage of PARP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	74-80
22330806-10	2012	Enhanced VEGF(120) secretion with either DNP or AICAR was markedly suppressed by PI3K inhibitor LY294002 (p&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	vascular endothelial growth factor A	Homo sapiens	9-13
22155408-4	2012	Knockdown of HN1 expression by siRNA silencing leads to an increase in Akt((S473)) phosphorylation, resulting in the translocation of androgen receptor (AR) to the nucleus; these effects can be abrogated by the non-specific Akt inhibitor LY294002 but not by the ERK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	238-246	AKT serine/threonine kinase 1	Homo sapiens	71-74
22155408-4	2012	Knockdown of HN1 expression by siRNA silencing leads to an increase in Akt((S473)) phosphorylation, resulting in the translocation of androgen receptor (AR) to the nucleus; these effects can be abrogated by the non-specific Akt inhibitor LY294002 but not by the ERK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	238-246	androgen receptor	Homo sapiens	134-151
22155408-4	2012	Knockdown of HN1 expression by siRNA silencing leads to an increase in Akt((S473)) phosphorylation, resulting in the translocation of androgen receptor (AR) to the nucleus; these effects can be abrogated by the non-specific Akt inhibitor LY294002 but not by the ERK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	238-246	androgen receptor	Homo sapiens	153-155
22198171-5	2012	The enhanced chronotropic effect of ANG II was attenuated by a phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, LY 294002 (10 muM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-126	angiotensinogen	Rattus norvegicus	36-42
22023263-11	2012	LY294002, but not U0126, significantly reduced this promotion effect of CYR61 on dNK cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cellular communication network factor 1	Homo sapiens	72-77
22023263-11	2012	LY294002, but not U0126, significantly reduced this promotion effect of CYR61 on dNK cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	deoxyribonucleoside kinase	Drosophila melanogaster	81-84
22315058-7	2012	LY294002, but not U0126, suppressed foetal bovine serum or heregulin-beta1-induced phosphorylation of Akt/GSK-3beta and snail expression together with the inhibition of 81B-Fb cell motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	102-105
22315058-7	2012	LY294002, but not U0126, suppressed foetal bovine serum or heregulin-beta1-induced phosphorylation of Akt/GSK-3beta and snail expression together with the inhibition of 81B-Fb cell motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Homo sapiens	106-115
22315058-7	2012	LY294002, but not U0126, suppressed foetal bovine serum or heregulin-beta1-induced phosphorylation of Akt/GSK-3beta and snail expression together with the inhibition of 81B-Fb cell motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	snail family transcriptional repressor 1	Homo sapiens	120-125
22245726-8	2012	A VEGFR kinase inhibitor, Ki8751, and a phosphatidylinositol 3-kinase-Akt inhibitor, LY294002, blocked tumor CM-induced MDR1 up-regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Homo sapiens	70-73
22245726-8	2012	A VEGFR kinase inhibitor, Ki8751, and a phosphatidylinositol 3-kinase-Akt inhibitor, LY294002, blocked tumor CM-induced MDR1 up-regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	ATP binding cassette subfamily B member 1	Homo sapiens	120-124
22235101-14	2012	The phosphoinositide 3-kinase (PI3K) inhibitor LY294002 inhibited FDG uptake in vitro in cervical cancer cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-29
22100392-5	2012	Interfering with Mek1/2 or PI3K using the inhibitors CI-1040 and LY-294002, respectively, inhibited PDGF-BB-induced MKP3 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-74	mitogen-activated protein kinase kinase 1	Mus musculus	17-23
22100392-5	2012	Interfering with Mek1/2 or PI3K using the inhibitors CI-1040 and LY-294002, respectively, inhibited PDGF-BB-induced MKP3 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-74	dual specificity phosphatase 6	Mus musculus	116-120
22240122-0	2012	Differential effects of LY294002 and wortmannin on inducible nitric oxide synthase expression in glomerular mesangial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	nitric oxide synthase 2, inducible	Mus musculus	51-82
22240122-3	2012	In the present study, we demonstrated the differential effects of two phosphatidylinositol 3-kinase (PI3K) inhibitors, LY294002 and wortmannin, on lipopolysaccharide- (LPS) and interferon (IFN)-gamma-induced NO production in a glomerular mesangial cell line, MES-13 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	toll-like receptor 4	Mus musculus	168-171
22240122-3	2012	In the present study, we demonstrated the differential effects of two phosphatidylinositol 3-kinase (PI3K) inhibitors, LY294002 and wortmannin, on lipopolysaccharide- (LPS) and interferon (IFN)-gamma-induced NO production in a glomerular mesangial cell line, MES-13 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	interferon gamma	Mus musculus	177-199
22240122-4	2012	At dosages without affecting cell viability of MES-13 cells, 5muM LY294002 showed a more-significant inhibitory effect on LPS/IFN-gamma-induced NO production, and iNOS protein and gene expressions than did 1muM wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	toll-like receptor 4	Mus musculus	122-125
22240122-4	2012	At dosages without affecting cell viability of MES-13 cells, 5muM LY294002 showed a more-significant inhibitory effect on LPS/IFN-gamma-induced NO production, and iNOS protein and gene expressions than did 1muM wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	interferon gamma	Mus musculus	126-135
22240122-4	2012	At dosages without affecting cell viability of MES-13 cells, 5muM LY294002 showed a more-significant inhibitory effect on LPS/IFN-gamma-induced NO production, and iNOS protein and gene expressions than did 1muM wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	nitric oxide synthase 2, inducible	Mus musculus	163-167
22240122-8	2012	LY294002 exhibited a more-significant inhibitory effect on NF-kappaB luciferase activities than wortmannin in LPS/IFN-gamma-stimulated MES-13 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	toll-like receptor 4	Mus musculus	110-113
22240122-8	2012	LY294002 exhibited a more-significant inhibitory effect on NF-kappaB luciferase activities than wortmannin in LPS/IFN-gamma-stimulated MES-13 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interferon gamma	Mus musculus	114-123
22240122-9	2012	Moreover, LY294002, but not wortmannin, accelerated iNOS protein degradation and reduced the iNOS dimer/monomer ratio in MES-13 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	nitric oxide synthase 2, inducible	Mus musculus	52-56
22240122-9	2012	Moreover, LY294002, but not wortmannin, accelerated iNOS protein degradation and reduced the iNOS dimer/monomer ratio in MES-13 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	nitric oxide synthase 2, inducible	Mus musculus	93-97
22357207-8	2012	Ly294002 (a PI3K inhibitor) and rapamycin (an mTOR inhibitor) could prevent the regulatory effects of leptin on the proliferation and apoptosis of HCT-116 cells via abrogating leptin-mediated PI3K/Akt/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	leptin	Homo sapiens	102-108
21545687-5	2012	Tumour necrosis factor-alpha (TNF-alpha) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 (p38 MAPK inhibitor), PD98059 (ERK inhibitor), LY294002 and Wortmannin (PI3K inhibitor) and SB328437 (CCR3 inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	tumor necrosis factor	Homo sapiens	30-39
21545687-5	2012	Tumour necrosis factor-alpha (TNF-alpha) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 (p38 MAPK inhibitor), PD98059 (ERK inhibitor), LY294002 and Wortmannin (PI3K inhibitor) and SB328437 (CCR3 inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
22357207-8	2012	Ly294002 (a PI3K inhibitor) and rapamycin (an mTOR inhibitor) could prevent the regulatory effects of leptin on the proliferation and apoptosis of HCT-116 cells via abrogating leptin-mediated PI3K/Akt/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	leptin	Homo sapiens	176-182
22357207-8	2012	Ly294002 (a PI3K inhibitor) and rapamycin (an mTOR inhibitor) could prevent the regulatory effects of leptin on the proliferation and apoptosis of HCT-116 cells via abrogating leptin-mediated PI3K/Akt/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	197-200
22357207-8	2012	Ly294002 (a PI3K inhibitor) and rapamycin (an mTOR inhibitor) could prevent the regulatory effects of leptin on the proliferation and apoptosis of HCT-116 cells via abrogating leptin-mediated PI3K/Akt/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	201-205
22145570-5	2012	Cocaine effects on morphology and ERK/Akt phosphorylation were inhibited by pre-incubation with the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	mitogen-activated protein kinase 1	Mus musculus	34-37
22240122-10	2012	Although both LY294002 and wortmannin are known as PI3K inhibitors, their differential effects on iNOS expression in MES-13 cells indicate that the effects of LY294002 on inhibiting NF-kappaB activation and accelerating iNOS protein degradation are through a mechanism independent of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	nitric oxide synthase 2, inducible	Mus musculus	220-224
22145570-5	2012	Cocaine effects on morphology and ERK/Akt phosphorylation were inhibited by pre-incubation with the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	thymoma viral proto-oncogene 1	Mus musculus	38-41
22301781-9	2012	The decrease of miR-16 and miR-195 expression by TSH was reproduced by forskolin and N(6),2"-O-dibutyryladenosine cAMP and reversed by the protein kinase A inhibitor H89 and the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	glycerophosphodiester phosphodiesterase 1	Homo sapiens	16-22
21698364-8	2012	We also found pretreated cells with TLR4 siRNA or the PI3 K inhibitor LY294002 could markedly block PI3K/Akt pathway activation and VSMCs migration mediated by HMGB1 (P both &lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Rattus norvegicus	105-108
21698364-8	2012	We also found pretreated cells with TLR4 siRNA or the PI3 K inhibitor LY294002 could markedly block PI3K/Akt pathway activation and VSMCs migration mediated by HMGB1 (P both &lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	high mobility group box 1	Rattus norvegicus	160-165
22083546-8	2012	Phosphorylation of Akt and MMP-2 production stimulated by oxLDL were attenuated by LY294002 (a specific inhibitor of PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
22083546-8	2012	Phosphorylation of Akt and MMP-2 production stimulated by oxLDL were attenuated by LY294002 (a specific inhibitor of PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	matrix metallopeptidase 2	Rattus norvegicus	27-32
22301781-9	2012	The decrease of miR-16 and miR-195 expression by TSH was reproduced by forskolin and N(6),2"-O-dibutyryladenosine cAMP and reversed by the protein kinase A inhibitor H89 and the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	microRNA 195	Homo sapiens	27-34
25774181-3	2012	These effects of curcumin on PI3K, Akt and Nrf2 were blocked by LY294002 (PI3k inhibitor) and NF-E2-related factor-2 siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Homo sapiens	35-38
23211059-9	2012	Furthermore, the protective effect of Epo could be blocked by PI3K inhibitor LY294002 (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	erythropoietin	Rattus norvegicus	38-41
27350769-0	2012	LY294002 induces differentiation and inhibits invasion of glioblastoma cells by targeting GSK-3beta and MMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Homo sapiens	90-99
27350769-5	2012	LY294002 also inhibits MMP-9 expression and invasion of C6 cells, assembling the role of metalloprotease (MMP) inhibitor AG3340.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	matrix metallopeptidase 9	Homo sapiens	23-28
27350769-6	2012	Taken together, these findings suggest differentiation-inducing and invasion-inhibitory effectiveness of LY294002 in glioblastomas, most likely involving inhibition of GSK-3beta and MMP respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	glycogen synthase kinase 3 beta	Homo sapiens	168-177
22265823-3	2012	The presence of PI3K inhibitor LY294002 completely blocked puerarin-induced activation of Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	90-93
22265823-4	2012	Moreover, puerarin decreased MPP(+)-induced cell death, which was blocked by phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	77-102
25774181-3	2012	These effects of curcumin on PI3K, Akt and Nrf2 were blocked by LY294002 (PI3k inhibitor) and NF-E2-related factor-2 siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
22287731-3	2012	MATERIALS AND METHODS: Inhibition of PI3K/Akt pathway signaling via LY294002 and Akti-1/2 was demonstrated by immunoblotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	42-45
21445974-10	2012	Moreover, LY294002, a PI3K inhibitor, sensitized melanoma cells to Bortezomib treatment, suggesting that downregulation of phospho-Akt by Sunitinib mediates the synergy obtained by Bortezomib + Sunitinib cotreatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	131-134
22187427-6	2012	HPIP overexpression in both CD34(+) and K562 cells was associated with increased activation of the PI3K/AKT pathway, and corresponding treatment with a PI3K-specific inhibitor, LY-294002, caused a reduction in clonogenic progenitor number in HPIP-expressing CD34(+) cells and decreased K562 cell differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-186	PBX homeobox interacting protein 1	Homo sapiens	0-4
22187427-6	2012	HPIP overexpression in both CD34(+) and K562 cells was associated with increased activation of the PI3K/AKT pathway, and corresponding treatment with a PI3K-specific inhibitor, LY-294002, caused a reduction in clonogenic progenitor number in HPIP-expressing CD34(+) cells and decreased K562 cell differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-186	AKT serine/threonine kinase 1	Homo sapiens	104-107
22187427-6	2012	HPIP overexpression in both CD34(+) and K562 cells was associated with increased activation of the PI3K/AKT pathway, and corresponding treatment with a PI3K-specific inhibitor, LY-294002, caused a reduction in clonogenic progenitor number in HPIP-expressing CD34(+) cells and decreased K562 cell differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-186	PBX homeobox interacting protein 1	Homo sapiens	242-246
22187427-6	2012	HPIP overexpression in both CD34(+) and K562 cells was associated with increased activation of the PI3K/AKT pathway, and corresponding treatment with a PI3K-specific inhibitor, LY-294002, caused a reduction in clonogenic progenitor number in HPIP-expressing CD34(+) cells and decreased K562 cell differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-186	CD34 molecule	Homo sapiens	258-262
22172953-7	2012	LY294002 increased cytosolic p53 with a concomitant decrease in nuclear p53, suggesting transfer of p53 to the cytosol where apoptosis might be initiated via the intrinsic mitochondrial pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor protein p53	Homo sapiens	29-32
22172953-7	2012	LY294002 increased cytosolic p53 with a concomitant decrease in nuclear p53, suggesting transfer of p53 to the cytosol where apoptosis might be initiated via the intrinsic mitochondrial pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor protein p53	Homo sapiens	72-75
22172953-7	2012	LY294002 increased cytosolic p53 with a concomitant decrease in nuclear p53, suggesting transfer of p53 to the cytosol where apoptosis might be initiated via the intrinsic mitochondrial pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor protein p53	Homo sapiens	72-75
22172953-8	2012	Protein changes described here suggest that the anti-angiogenic effects of LY294002 may be related to p53; the mutational status of p53 in CRC may be an important determinant of the efficacy of PI3K inhibitors for treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	tumor protein p53	Homo sapiens	102-105
22081709-7	2012	When the endogenous Akt was abolished by LY294002, the antiapoptotic actions of mitochondrial Akt remained effective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	20-23
22081709-7	2012	When the endogenous Akt was abolished by LY294002, the antiapoptotic actions of mitochondrial Akt remained effective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	94-97
22298254-5	2012	The enhancement of HKII levels and lactate production in MM cells by OCs were mostly abrogated by the PI3K inhibitor LY294002, suggesting activation of glycolysis in MM cells by OCs via the PI3K-Akt-HKII pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	hexokinase 2	Homo sapiens	19-23
22252008-5	2012	Here we show that in the mouse breast cancer cell lines, 67NR and 4T1, autophagy is induced by the DNA damaging agent cisplatin or by drugs that selectively target autophagy regulation, the PtdIns3K inhibitor LY294002, and the mTOR inhibitor rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	209-217	mechanistic target of rapamycin kinase	Mus musculus	227-231
22019695-7	2012	Activation of the Nrf2/HO-1 system after sulforaphane treatment was suppressed by pretreatment with NAC or Ly294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
22019695-7	2012	Activation of the Nrf2/HO-1 system after sulforaphane treatment was suppressed by pretreatment with NAC or Ly294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	heme oxygenase 1	Homo sapiens	23-27
21922131-5	2012	HIF-1alpha could be blocked by             PI3K inhibitor LY294002, indicating HIF-1alpha activation was regulated by PI3K/Akt             pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
21922131-5	2012	HIF-1alpha could be blocked by             PI3K inhibitor LY294002, indicating HIF-1alpha activation was regulated by PI3K/Akt             pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
21922131-5	2012	HIF-1alpha could be blocked by             PI3K inhibitor LY294002, indicating HIF-1alpha activation was regulated by PI3K/Akt             pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Homo sapiens	123-126
22298254-5	2012	The enhancement of HKII levels and lactate production in MM cells by OCs were mostly abrogated by the PI3K inhibitor LY294002, suggesting activation of glycolysis in MM cells by OCs via the PI3K-Akt-HKII pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	195-198
22298254-5	2012	The enhancement of HKII levels and lactate production in MM cells by OCs were mostly abrogated by the PI3K inhibitor LY294002, suggesting activation of glycolysis in MM cells by OCs via the PI3K-Akt-HKII pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	hexokinase 2	Homo sapiens	199-203
21800153-3	2012	In addition, NaHS up-regulated the expression of Bcl-2 and blocked MPP(+)-induced down-regulation of Bcl-2, and this augmentation of Bcl-2 expression was prevented by both glybenclamide and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	BCL2, apoptosis regulator	Rattus norvegicus	49-54
22282239-10	2012	Our data showed that LY294002 and wortmannin, phosphatidylinositol 3-kinase (PI3K) and PI3K-like kinase inhibitors, increased Pim mRNA expression in ECs without altering the mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	126-129
21480393-7	2012	For study of mechanism, the ADAM17 inhibitor TAPI-2 and the PI3K-AKT inhibitor LY294002 were used to counteract high-ADAM17 expression and the activated PI3K-AKT pathway, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	65-68
22379573-9	2012	On western blots, Akt-phosphorylation was induced during pretreatment with midazolam; it was diminished during co-treatment with LY-294002, an inhibitor of Akt-phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-138	AKT serine/threonine kinase 1	Homo sapiens	18-21
22379573-9	2012	On western blots, Akt-phosphorylation was induced during pretreatment with midazolam; it was diminished during co-treatment with LY-294002, an inhibitor of Akt-phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-138	AKT serine/threonine kinase 1	Homo sapiens	156-159
21480393-7	2012	For study of mechanism, the ADAM17 inhibitor TAPI-2 and the PI3K-AKT inhibitor LY294002 were used to counteract high-ADAM17 expression and the activated PI3K-AKT pathway, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	ADAM metallopeptidase domain 17	Homo sapiens	117-123
21480393-7	2012	For study of mechanism, the ADAM17 inhibitor TAPI-2 and the PI3K-AKT inhibitor LY294002 were used to counteract high-ADAM17 expression and the activated PI3K-AKT pathway, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	158-161
21480393-15	2012	ADAM17 activated, whereas ADAM17 siRNA, TAPI-2, and LY294002 deactivated the EGFR-PI3K-AKT signal pathway, which correlated with U87 cell malignant phenotype changes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	87-90
21967732-10	2012	Treatment with a PI3-kinase inhibitor (LY-294002) or a MEK/ERK inhibitor (U0126) for 1 h prior to and during the FGF-2 treatment, each partially blocked the increased cystine uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	fibroblast growth factor 2	Homo sapiens	113-118
22086271-0	2012	LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation             of the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	100-103
22086271-9	2012	In addition, p-Akt and Bcl-2, which can promote TMZ resistance, were markedly decreased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	AKT serine/threonine kinase 1	Homo sapiens	15-18
22086271-9	2012	In addition, p-Akt and Bcl-2, which can promote TMZ resistance, were markedly decreased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	BCL2 apoptosis regulator	Homo sapiens	23-28
22086271-10	2012	These findings suggest that LY294002 enhances the cytotoxicity of TMZ by down-regulation of the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	101-104
22101248-5	2012	Transwell migration assay showed that RANKL-induced MDA-MB-231 cell migration was significantly blocked by the decoy receptor osteoprotegerin (OPG), and was also inhibited by the PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	TNF superfamily member 11	Homo sapiens	38-43
22740919-6	2012	The sRANKL-induced migration was blocked with RANKL inhibitor osteoprotegerin (OPG), MEK inhibitor PD98059, PI3K inhibitor LY294002 and Src inhibitor PP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	TNF superfamily member 11	Homo sapiens	5-10
21617941-5	2012	Furthermore, the inhibitory effect of bufalin on pERK was blocked by the PI3kinase inhibitor LY294002, suggesting that the reduction in pERK induced by bufalin might be mediated by AKT in these two HCC cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	49-53
21617941-5	2012	Furthermore, the inhibitory effect of bufalin on pERK was blocked by the PI3kinase inhibitor LY294002, suggesting that the reduction in pERK induced by bufalin might be mediated by AKT in these two HCC cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	136-140
22138155-8	2012	Using LY294002 to block phosphoinositide 3-kinases (PI3K)/Akt signaling pathway prevented the phosphorylation of mTOR and attenuated the neuroprotection of FLZ in MN9D cells challenged by MPP(+).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	thymoma viral proto-oncogene 1	Mus musculus	58-61
21617941-5	2012	Furthermore, the inhibitory effect of bufalin on pERK was blocked by the PI3kinase inhibitor LY294002, suggesting that the reduction in pERK induced by bufalin might be mediated by AKT in these two HCC cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Homo sapiens	181-184
22166375-7	2012	GSK3beta inhibition was achieved with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	glycogen synthase kinase-3 beta	Cavia porcellus	0-8
22455747-19	2012	LY294002 reversed the effects of FSH on increasing the expression of p-Akt and the ratio of NF-kappaB p65 in the nucleus versus cytoplasm, there were significant differences among LY294002 group, FSH + LY294002 group and FSH group (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	71-74
22455747-19	2012	LY294002 reversed the effects of FSH on increasing the expression of p-Akt and the ratio of NF-kappaB p65 in the nucleus versus cytoplasm, there were significant differences among LY294002 group, FSH + LY294002 group and FSH group (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nuclear factor kappa B subunit 1	Homo sapiens	92-101
22455747-19	2012	LY294002 reversed the effects of FSH on increasing the expression of p-Akt and the ratio of NF-kappaB p65 in the nucleus versus cytoplasm, there were significant differences among LY294002 group, FSH + LY294002 group and FSH group (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	102-105
22172327-5	2012	Furthermore, LY294002 (Akt inhibitor) or PD98059 (ERK1/2 inhibitor) significantly enhanced active lipids of Ganoderma lucidum spores-induced apoptosis in THP-1 cells, whereas caspase inhibitors or SP600125 (JNK inhibitor), decreased apoptosis in THP-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	23-26
22172327-5	2012	Furthermore, LY294002 (Akt inhibitor) or PD98059 (ERK1/2 inhibitor) significantly enhanced active lipids of Ganoderma lucidum spores-induced apoptosis in THP-1 cells, whereas caspase inhibitors or SP600125 (JNK inhibitor), decreased apoptosis in THP-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	GLI family zinc finger 2	Homo sapiens	154-159
22172327-5	2012	Furthermore, LY294002 (Akt inhibitor) or PD98059 (ERK1/2 inhibitor) significantly enhanced active lipids of Ganoderma lucidum spores-induced apoptosis in THP-1 cells, whereas caspase inhibitors or SP600125 (JNK inhibitor), decreased apoptosis in THP-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	mitogen-activated protein kinase 8	Homo sapiens	207-210
22172327-5	2012	Furthermore, LY294002 (Akt inhibitor) or PD98059 (ERK1/2 inhibitor) significantly enhanced active lipids of Ganoderma lucidum spores-induced apoptosis in THP-1 cells, whereas caspase inhibitors or SP600125 (JNK inhibitor), decreased apoptosis in THP-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	GLI family zinc finger 2	Homo sapiens	246-251
22138155-8	2012	Using LY294002 to block phosphoinositide 3-kinases (PI3K)/Akt signaling pathway prevented the phosphorylation of mTOR and attenuated the neuroprotection of FLZ in MN9D cells challenged by MPP(+).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	mechanistic target of rapamycin kinase	Mus musculus	113-117
21861235-11	2012	LY294002 inhibitor could abrogate the activation of PI3K/Akt pathway in those cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	57-60
22251375-7	2012	JEV-induced MMP-9 expression and promoter activity were inhibited by pretreatment with inhibitors of AP-1 (tanshinone), c-Src (PP1), PDGFR (AG1296), and PI3K (LY294002), and by transfection with siRNAs of c-Jun, c-Fos, PDGFR, and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	101-105
21749866-4	2012	In addition, PI-3Kinase Inhibitor (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, LY294002) could suppress the Chlorogenic acid-induced: (1) the cellular protective role, (2) the increase of the FOXO family genes expression, (3) increased expression of Bcl-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-83	BCL2 apoptosis regulator	Homo sapiens	256-261
21749866-4	2012	In addition, PI-3Kinase Inhibitor (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, LY294002) could suppress the Chlorogenic acid-induced: (1) the cellular protective role, (2) the increase of the FOXO family genes expression, (3) increased expression of Bcl-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	BCL2 apoptosis regulator	Homo sapiens	256-261
22038823-8	2012	Inhibition of Akt signaling with LY294002 or a dominant negative Akt plasmid increased cytokine-stimulated nitrite production and iNOS protein expression and blocked the inhibitory effects of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
22038823-8	2012	Inhibition of Akt signaling with LY294002 or a dominant negative Akt plasmid increased cytokine-stimulated nitrite production and iNOS protein expression and blocked the inhibitory effects of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	nitric oxide synthase 2	Rattus norvegicus	130-134
22209843-2	2012	LY294002 (PI3K inhibitor) or UCN-01 (PDK-1 inhibitor) increased the percentage of apoptotic cells in the granulosa cells treated with BMP-4 or BMP-7.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	bone morphogenetic protein 4	Homo sapiens	134-139
22209843-2	2012	LY294002 (PI3K inhibitor) or UCN-01 (PDK-1 inhibitor) increased the percentage of apoptotic cells in the granulosa cells treated with BMP-4 or BMP-7.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	bone morphogenetic protein 7	Homo sapiens	143-148
22081609-7	2012	Inhibition of Akt signaling by treatment with dominant-negative Akt or LY294002 blocked the stimulatory effects of omentin on differentiation and survival of HUVECs and reversed omentin-stimulated eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	thymoma viral proto-oncogene 1	Mus musculus	14-17
22081609-7	2012	Inhibition of Akt signaling by treatment with dominant-negative Akt or LY294002 blocked the stimulatory effects of omentin on differentiation and survival of HUVECs and reversed omentin-stimulated eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	intelectin 1	Homo sapiens	115-122
22081609-7	2012	Inhibition of Akt signaling by treatment with dominant-negative Akt or LY294002 blocked the stimulatory effects of omentin on differentiation and survival of HUVECs and reversed omentin-stimulated eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	intelectin 1	Homo sapiens	178-185
22419429-8	2012	Pharmacological inhibition of AKT by LY294002 effectively suppressed NF-kappaB activation and PON1 gene expression, suggesting that AKT was an upstream regulator of GP50E-mediated biological events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	30-33
22419429-8	2012	Pharmacological inhibition of AKT by LY294002 effectively suppressed NF-kappaB activation and PON1 gene expression, suggesting that AKT was an upstream regulator of GP50E-mediated biological events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	nuclear factor kappa B subunit 1	Homo sapiens	69-78
22419429-8	2012	Pharmacological inhibition of AKT by LY294002 effectively suppressed NF-kappaB activation and PON1 gene expression, suggesting that AKT was an upstream regulator of GP50E-mediated biological events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	paraoxonase 1	Homo sapiens	94-98
22419429-8	2012	Pharmacological inhibition of AKT by LY294002 effectively suppressed NF-kappaB activation and PON1 gene expression, suggesting that AKT was an upstream regulator of GP50E-mediated biological events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	132-135
21932108-7	2012	The additions of siRNA c-Met to block HGF or LY294002 to inhibit p-AKT could downregulate beta-catenin and inhibit the proliferation promotion caused by HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	67-70
21932108-7	2012	The additions of siRNA c-Met to block HGF or LY294002 to inhibit p-AKT could downregulate beta-catenin and inhibit the proliferation promotion caused by HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	catenin beta 1	Homo sapiens	90-102
21932108-7	2012	The additions of siRNA c-Met to block HGF or LY294002 to inhibit p-AKT could downregulate beta-catenin and inhibit the proliferation promotion caused by HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	hepatocyte growth factor	Homo sapiens	153-156
22994717-5	2012	LY294002 prevented phosphorylation of protein kinase B (PKB/Akt) by inhibition of PI3K phosphorylation activity, thereby inducing G0/G1 cell cycle arrest and apoptosis in osteosarcoma CSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	56-63
22994717-6	2012	Further studies also demonstrated that apoptosis induction by LY294002 is accompanied by activation of caspase-9, caspase-3 and PARP, which are involved in the mitochondrial apoptosis pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	caspase 9	Homo sapiens	103-112
22938480-9	2012	Phosphorylation of JNK and Akt were abolished by the specific inhibitors SP600125 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	mitogen-activated protein kinase 8	Homo sapiens	19-22
22994717-6	2012	Further studies also demonstrated that apoptosis induction by LY294002 is accompanied by activation of caspase-9, caspase-3 and PARP, which are involved in the mitochondrial apoptosis pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	caspase 3	Homo sapiens	114-123
22938480-9	2012	Phosphorylation of JNK and Akt were abolished by the specific inhibitors SP600125 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	AKT serine/threonine kinase 1	Homo sapiens	27-30
22994717-6	2012	Further studies also demonstrated that apoptosis induction by LY294002 is accompanied by activation of caspase-9, caspase-3 and PARP, which are involved in the mitochondrial apoptosis pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	collagen type XI alpha 2 chain	Homo sapiens	128-132
21946431-6	2012	The effect of 8-OH-DPAT was accompanied by an increase in the active phosphorylation of Akt, and was blocked by LY294002, an inhibitor of phosphoinositide 3-kinases (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	thymoma viral proto-oncogene 1	Mus musculus	88-91
22005520-8	2012	The effects of LY2 and LY3 on p50 translocation and on cytokine production in LPS-stimulated macrophages are thus consistent with specific PI3K-independent inhibition of p50 NFkappaB homodimer activity by LY2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-18	nuclear factor kappa B subunit 1	Homo sapiens	30-33
22005520-8	2012	The effects of LY2 and LY3 on p50 translocation and on cytokine production in LPS-stimulated macrophages are thus consistent with specific PI3K-independent inhibition of p50 NFkappaB homodimer activity by LY2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-18	nuclear factor kappa B subunit 1	Homo sapiens	170-173
22005520-8	2012	The effects of LY2 and LY3 on p50 translocation and on cytokine production in LPS-stimulated macrophages are thus consistent with specific PI3K-independent inhibition of p50 NFkappaB homodimer activity by LY2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-18	nuclear factor kappa B subunit 1	Homo sapiens	174-182
22975513-6	2012	This induction was completely inhibited by treatment with phosphatidylinositol (PI) 3-kinase inhibitors such as LY294002 or wortmannin, and by the nuclear factor-kappa B (NF-kappaB) inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	nuclear factor kappa B subunit 1	Homo sapiens	171-180
22012952-6	2012	P13K inhibitor LY294002 and Akt1/2 kinase inhibitor but not the ERK1/2 kinase (MEK) inhibitors PD98059 and U0126 blocked the insulin-induced reduction in AdipoR1 expression and AMPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	adiponectin receptor 1	Rattus norvegicus	154-161
22012952-7	2012	Insulin induced forkhead/winged helix box gene group O-1 (FoxO1) phosphorylation and translocation from the nucleus to the cytosol, and this was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	forkhead box O1	Rattus norvegicus	58-63
22012952-9	2012	In electrophoretic mobility shift assay and chromatin immunoprecipitation, FoxO1 bound to the putative site from -167 to -157 bp of the AdipoR1 promoter both in vitro and in living cells; insulin suppressed this binding, which was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	forkhead box O1	Rattus norvegicus	75-80
22012952-9	2012	In electrophoretic mobility shift assay and chromatin immunoprecipitation, FoxO1 bound to the putative site from -167 to -157 bp of the AdipoR1 promoter both in vitro and in living cells; insulin suppressed this binding, which was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	adiponectin receptor 1	Rattus norvegicus	136-143
22005520-0	2012	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappaB inhibition, in a PI3K-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	nuclear factor kappa B subunit 1	Homo sapiens	109-112
22005520-0	2012	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappaB inhibition, in a PI3K-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	nuclear factor kappa B subunit 1	Homo sapiens	113-134
22005520-1	2012	The Phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 (LY2), has been previously reported to inhibit nuclear factor kappaB (NFkappaB) activity, in a PI3K-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	nuclear factor kappa B subunit 1	Homo sapiens	108-129
22005520-1	2012	The Phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 (LY2), has been previously reported to inhibit nuclear factor kappaB (NFkappaB) activity, in a PI3K-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	nuclear factor kappa B subunit 1	Homo sapiens	131-139
22005520-1	2012	The Phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 (LY2), has been previously reported to inhibit nuclear factor kappaB (NFkappaB) activity, in a PI3K-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-55	nuclear factor kappa B subunit 1	Homo sapiens	108-129
22005520-1	2012	The Phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 (LY2), has been previously reported to inhibit nuclear factor kappaB (NFkappaB) activity, in a PI3K-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-55	nuclear factor kappa B subunit 1	Homo sapiens	131-139
22005520-3	2012	We found that LY2 specifically diminished the level of p50, but not p65, NFkappaB in the nucleus of LPS-stimulated mouse RAW264.7 macrophages and human THP-1 monocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	55-58
22005520-3	2012	We found that LY2 specifically diminished the level of p50, but not p65, NFkappaB in the nucleus of LPS-stimulated mouse RAW264.7 macrophages and human THP-1 monocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-81
22005520-3	2012	We found that LY2 specifically diminished the level of p50, but not p65, NFkappaB in the nucleus of LPS-stimulated mouse RAW264.7 macrophages and human THP-1 monocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-17	GLI family zinc finger 2	Homo sapiens	152-157
22005520-5	2012	We further show that LY2 inhibited LPS-induced IL-10 expression by RAW264.7 macrophages, in a PI3K-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-24	interleukin 10	Homo sapiens	47-52
23123465-4	2012	LY294002 and wortmannin, two PI3-K inhibitors, significantly prevented gemcitabine-induced cytotoxicity in INS-1 cells, indicating that the PI3-K/Akt pathway is involved in gemcitabine-induced cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin 1	Rattus norvegicus	107-112
23123465-4	2012	LY294002 and wortmannin, two PI3-K inhibitors, significantly prevented gemcitabine-induced cytotoxicity in INS-1 cells, indicating that the PI3-K/Akt pathway is involved in gemcitabine-induced cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	146-149
23123465-5	2012	Gemcitabine-induced Akt phosphorylation in INS-1 cells was prevented by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Rattus norvegicus	20-23
23123465-5	2012	Gemcitabine-induced Akt phosphorylation in INS-1 cells was prevented by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	insulin 1	Rattus norvegicus	43-48
21964322-7	2012	Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	thymoma viral proto-oncogene 1	Mus musculus	161-164
21964322-7	2012	Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	glycogen synthase kinase 3 beta	Mus musculus	169-173
21964322-7	2012	Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	Sp7 transcription factor 7	Mus musculus	192-199
21964322-7	2012	Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	osteomodulin	Mus musculus	201-213
21964322-7	2012	Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	osteoglycin	Mus musculus	218-229
21981022-8	2012	The effect of Irgm3 on ER stress and CVB3 infection was diminished by the PI3K inhibitor, LY294002, while inhibitors of ERK, JNK and p38 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	interferon gamma induced GTPase	Mus musculus	14-19
22508044-4	2012	Moreover, LY294002, an Akt phosphorylation inhibitor, was used to determine whether the suppression of metastatic behavior of colon carcinoma cells was mediated by Akt phosphorylation that was confirmed by EMSA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	thymoma viral proto-oncogene 1	Mus musculus	23-26
22508044-8	2012	However, no additional changes were noted following inhibition of PI3K/Akt pathway by LY294002 in the PARG-shRNA cells; these cells displayed reduced number of liver metastases when characterized in the murine in vivo model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	thymoma viral proto-oncogene 1	Mus musculus	71-74
21946431-6	2012	The effect of 8-OH-DPAT was accompanied by an increase in the active phosphorylation of Akt, and was blocked by LY294002, an inhibitor of phosphoinositide 3-kinases (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	138-164
22122966-8	2012	Incubation with LY294002 or Akt-I decreased the activity of PI3K and Akt but augmented the elevation of cGMP caused by NO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	69-72
22508063-9	2012	When PD98059, U0126 and LY294002 were pre-incubated with the cells for 30 min they diminished rPer a 7 induced reduction of TLR9 expression and IL-12 release, indicating these events are via activation of ERK and PI3K/Akt signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	toll-like receptor 9	Mus musculus	124-128
22100227-6	2012	In addition, berberine-induced HO-1 expression was attenuated by PI 3-kinase (phosphatidylinositol 3-kinase) inhibitors LY294002 and wortmannin, and an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	heme oxygenase 1	Rattus norvegicus	31-35
22064360-8	2012	Addition of pharmacological kinase inhibitors, U0126, SP600125, and LY294002, caused cytotoxicity and the last significantly attenuated NOB- and DTF-mediated antiapoptotic actions, indicating the involvement of PI3K/Akt signaling in their cytoprotective effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Rattus norvegicus	216-219
22137120-13	2012	Inhibition of PI3K with LY294002 prevented IFNgamma-mediated actin polymerization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	interferon gamma	Homo sapiens	43-51
22370167-6	2012	bFGF promoted apoptosis of the myofibroblasts but not of the fibroblasts, even in the presence of two different inhibitors, either LY294002 or an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	fibroblast growth factor 2	Homo sapiens	0-4
22312287-8	2012	In addition, the procyanidin-mediated Nrf2 expression was partly attenuated by PI3K inhibitor LY294002, and almost completely by p38 inhibitor SB202190, but neither by JNK inhibitor SP600125 nor by MEK1/2 inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
22193240-6	2012	A pharmacological inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt pathway, LY294002, abrogated IKK/IkappaB/NF-kappaB-mediated iNOS gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	68-71
22193240-6	2012	A pharmacological inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt pathway, LY294002, abrogated IKK/IkappaB/NF-kappaB-mediated iNOS gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	nuclear factor kappa B subunit 1	Homo sapiens	113-122
22193240-6	2012	A pharmacological inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt pathway, LY294002, abrogated IKK/IkappaB/NF-kappaB-mediated iNOS gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	nitric oxide synthase 2	Homo sapiens	132-136
22761619-6	2012	Ad.BD110 and Ad.Akt decreased I(K) and these decrements were attenuated by LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-84	AKT serine/threonine kinase 1	Rattus norvegicus	16-19
22761619-7	2012	The IGF-1 treatments decreased both I(K) and I(K1) but only the I(K) decrement was attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	insulin-like growth factor 1	Rattus norvegicus	4-9
23094196-11	2012	Addition of LY294002 suppressed TNF production by macrophages by 20%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	tumor necrosis factor	Mus musculus	32-35
23094196-13	2012	Induction of TNF was abolished when LY294002 was added and the suppression became uniform.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	tumor necrosis factor	Mus musculus	13-16
22408435-5	2012	In addition, A549 cells were treated by Akt inhibitor LY294002 in combination with bufalin and the activation of Akt and Caspase-3 as well as the expression levels of Bax, Bcl-2 and livin were examined by Western blot analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	40-43
22155101-10	2012	Pretreatment with Ly294002 a PI3 MAPK inhibitor significantly attenuated FP/SAL induced SOCS-3 expression in BAEpCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	suppressor of cytokine signaling 3	Homo sapiens	88-94
22080879-2	2012	LY294002 (PI3K inhibitor) and metformin (5"-adenosine monophosphate [AMP]-activated protein kinase [AMPK] activator) are 2 drugs that were known to inhibit mTOR expression through the AKT-dependent and AKT-independent pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	156-160
22080879-2	2012	LY294002 (PI3K inhibitor) and metformin (5"-adenosine monophosphate [AMP]-activated protein kinase [AMPK] activator) are 2 drugs that were known to inhibit mTOR expression through the AKT-dependent and AKT-independent pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	184-187
22080879-2	2012	LY294002 (PI3K inhibitor) and metformin (5"-adenosine monophosphate [AMP]-activated protein kinase [AMPK] activator) are 2 drugs that were known to inhibit mTOR expression through the AKT-dependent and AKT-independent pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	202-205
22080879-7	2012	RESULTS: Our study showed that LY294002 and metformin in combination could simultaneously enhance the repression of the PI3K/AKT/mTOR pathway and the activation of the AMPK/ACC pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	125-128
22080879-7	2012	RESULTS: Our study showed that LY294002 and metformin in combination could simultaneously enhance the repression of the PI3K/AKT/mTOR pathway and the activation of the AMPK/ACC pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	mechanistic target of rapamycin kinase	Homo sapiens	129-133
22312289-5	2012	Anti-Lewis y antibody, ERK and PI3K pathway inhibitors PD98059 and LY294002 reduced the difference in cyclin and CKI expression caused by Lewis y overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	choline kinase alpha	Homo sapiens	113-116
22312289-5	2012	Anti-Lewis y antibody, ERK and PI3K pathway inhibitors PD98059 and LY294002 reduced the difference in cyclin and CKI expression caused by Lewis y overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	proliferating cell nuclear antigen	Homo sapiens	102-108
22072736-9	2012	AKT was highly phosphorylated in OsisSC compared with HSC and inhibition of phosphatidylinositol 3-kinase, with LY294002, increased levels of FOXO1 protein as well as IGFBP1 mRNA in the presence of M+A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Homo sapiens	0-3
21972215-8	2012	The migration distance of BAEC on PU-Au 43.5 ppm was greater than that of HSF, and was significantly reduced by LY294002 or Y-27632 but not SU-1498.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	interleukin 6	Homo sapiens	74-77
23275900-7	2012	Both RAPA and LY294002 reduced levels of phospho-AKT, phospho-mTOR, phospho-p70S6k and phospho-4EBP1 expression (P &lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	49-52
23275900-7	2012	Both RAPA and LY294002 reduced levels of phospho-AKT, phospho-mTOR, phospho-p70S6k and phospho-4EBP1 expression (P &lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	mechanistic target of rapamycin kinase	Homo sapiens	62-66
23275900-7	2012	Both RAPA and LY294002 reduced levels of phospho-AKT, phospho-mTOR, phospho-p70S6k and phospho-4EBP1 expression (P &lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	ribosomal protein S6 kinase B1	Homo sapiens	76-82
23275900-10	2012	The inhibitors of PI3K/AKT/mTOR signaling pathway, RAPA and LY294002, could inhibited the PI3K/AKT/mTOR signaling pathway by reducing the levels of phosphorylation of mTOR pathway components.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	23-26
23275900-10	2012	The inhibitors of PI3K/AKT/mTOR signaling pathway, RAPA and LY294002, could inhibited the PI3K/AKT/mTOR signaling pathway by reducing the levels of phosphorylation of mTOR pathway components.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	mechanistic target of rapamycin kinase	Homo sapiens	27-31
23275900-10	2012	The inhibitors of PI3K/AKT/mTOR signaling pathway, RAPA and LY294002, could inhibited the PI3K/AKT/mTOR signaling pathway by reducing the levels of phosphorylation of mTOR pathway components.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	95-98
23275900-10	2012	The inhibitors of PI3K/AKT/mTOR signaling pathway, RAPA and LY294002, could inhibited the PI3K/AKT/mTOR signaling pathway by reducing the levels of phosphorylation of mTOR pathway components.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	mechanistic target of rapamycin kinase	Homo sapiens	99-103
23275900-10	2012	The inhibitors of PI3K/AKT/mTOR signaling pathway, RAPA and LY294002, could inhibited the PI3K/AKT/mTOR signaling pathway by reducing the levels of phosphorylation of mTOR pathway components.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	mechanistic target of rapamycin kinase	Homo sapiens	99-103
22863784-6	2012	Pretreatment either with anti-RAGE antibody or LY294002 prior to AGE-BSA decreases LOX-1 and p-mTOR expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	oxidized low density lipoprotein receptor 1	Homo sapiens	83-88
22863784-6	2012	Pretreatment either with anti-RAGE antibody or LY294002 prior to AGE-BSA decreases LOX-1 and p-mTOR expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	mechanistic target of rapamycin kinase	Homo sapiens	95-99
22900166-5	2012	Contraction-induced iNOS expression required FAK and phosphatidylinositol 3-kinase (PI(3)K), as both PF573228 and LY294002 (10 muM, 24 h) eliminated contraction-induced iNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	nitric oxide synthase 2	Rattus norvegicus	20-24
22131333-5	2012	Inhibition of the PI3K by LY294002 reduces formation of osteoclasts and attenuates the expression of NFATc1, but not that of c-Fos.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	101-107
21879332-5	2012	Furthermore, the combined treatment with LY294002, a specific inhibitor of the PI3K/Akt kinase pathway, and GNA showed a synergistic or additive effect on the growth of U251 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	84-87
22900166-5	2012	Contraction-induced iNOS expression required FAK and phosphatidylinositol 3-kinase (PI(3)K), as both PF573228 and LY294002 (10 muM, 24 h) eliminated contraction-induced iNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	protein tyrosine kinase 2	Rattus norvegicus	45-48
22900166-5	2012	Contraction-induced iNOS expression required FAK and phosphatidylinositol 3-kinase (PI(3)K), as both PF573228 and LY294002 (10 muM, 24 h) eliminated contraction-induced iNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	nitric oxide synthase 2	Rattus norvegicus	169-173
23112573-16	2012	Insulin also increased the ratio of phospho-ERK/total-ERK in animals with normal visual exposure and in animals wearing positive lenses, compared to U0126- and Ly294002-injected eyes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	insulin	Gallus gallus	0-7
22249107-6	2012	The presence of either the mitogen-activated protein kinase (MAPK) inhibitor (PD98059), or PI-3K inhibitor (LY294002), reduced the effect of adiponectin in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	adiponectin, C1Q and collagen domain containing	Homo sapiens	141-152
21964769-10	2012	Moreover, LY294002, a phosphatidylinositol 3-kinase (PI-3K) inhibitor, significantly abrogated liraglutide-induced effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	22-51
21892609-9	2012	LY294002, a specific Akt inhibitor, reduced both basal and HGF-induced uPA secretion and migration of MDA-MB-231 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	21-24
21892609-9	2012	LY294002, a specific Akt inhibitor, reduced both basal and HGF-induced uPA secretion and migration of MDA-MB-231 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hepatocyte growth factor	Homo sapiens	59-62
21892609-9	2012	LY294002, a specific Akt inhibitor, reduced both basal and HGF-induced uPA secretion and migration of MDA-MB-231 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	plasminogen activator, urokinase	Homo sapiens	71-74
22509106-10	2012	Furthermore, NGF affected cell cycle progression of HCECs by regulating cyclin D through Akt and Erk activation upon treatment with the pathway inhibitors, LY294002 for Akt or PD98059 for Erk pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	mitogen-activated protein kinase 1	Homo sapiens	97-100
22509106-10	2012	Furthermore, NGF affected cell cycle progression of HCECs by regulating cyclin D through Akt and Erk activation upon treatment with the pathway inhibitors, LY294002 for Akt or PD98059 for Erk pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	AKT serine/threonine kinase 1	Homo sapiens	169-172
21875668-4	2012	Thus, the increased activity of GSK3beta induced by LY294002 and detected by dephosphorylation at Ser9 was prevented by both compounds.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	glycogen synthase kinase 3 beta	Homo sapiens	32-40
23461061-5	2012	Treatment of MEK inhibitor PD98059 or PI3K inhibitor LY294002 decreased cell invasion along with downregulation of MMP-2 and MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	matrix metallopeptidase 2	Homo sapiens	115-120
23461061-5	2012	Treatment of MEK inhibitor PD98059 or PI3K inhibitor LY294002 decreased cell invasion along with downregulation of MMP-2 and MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	matrix metallopeptidase 9	Homo sapiens	125-130
22519916-6	2012	Furthermore, the treatment of inhibitors specific for Akt (LY294002) and ERK1/2 (U0126) to A549 cells resulted in reduced activity of proMMP-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	54-57
22100225-7	2012	PI3K inhibitor LY294002 abolished ghrelin-induced phosphorylation of Akt, but had no effect on ERK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	ghrelin and obestatin prepropeptide	Rattus norvegicus	34-41
22100225-7	2012	PI3K inhibitor LY294002 abolished ghrelin-induced phosphorylation of Akt, but had no effect on ERK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Rattus norvegicus	69-72
23272133-9	2012	PC-3M-MM2 cells also exhibited high levels of phospho-Akt (pAkt), which were reduced by both resveratrol and LY294002 (a PI3-kinase inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	AKT serine/threonine kinase 1	Homo sapiens	54-57
23285096-9	2012	GTP-induced apoptosis was attenuated with JNK inhibitor, SP600125 in both cell lines; whereas PI3K-Akt inhibitor, LY294002 resulted in increased cell death prominently in LNCaPshp53 cells, establishing the role of two distinct pathways of GTP-mediated apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Homo sapiens	99-102
23308088-4	2012	Additionally, increased levels of nuclear beta-catenin phosphorylated at Serine-552 in cultured primary hepatoblasts, Mat1a(-/-) cells, and also in ex vivo embryonic liver explants indicate AKT-dependent activation of beta-catenin downstream of FGFR activation; conversely, the addition of AKT inhibitor Ly294002 completely abrogated beta-catenin activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	304-312	catenin (cadherin associated protein), beta 1	Mus musculus	42-54
23095677-6	2012	Transcription inhibitor actinomycin D and PI3K inhibitor LY294002 abrogated the augmenting effect of propofol on the mRNA level of ACE2 in HPAECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	angiotensin converting enzyme 2	Homo sapiens	131-135
23272152-9	2012	mTORC1 activity was sensitive to LY294002 and rapamycin or transfection of cells with GRP78 dsRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	CREB regulated transcription coactivator 1	Mus musculus	0-6
23272133-10	2012	MiR-21 expression in these cells appeared to be dependent on Akt, as LY294002 reduced the levels of miR-21 along with a concurrent increase in PDCD4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	microRNA 21	Homo sapiens	0-6
23272152-12	2012	mTORC2 activity was sensitive to LY294002 and transfection of cells with GRP78 dsRNA, but insensitive to rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	CREB regulated transcription coactivator 2	Mus musculus	0-6
23272133-10	2012	MiR-21 expression in these cells appeared to be dependent on Akt, as LY294002 reduced the levels of miR-21 along with a concurrent increase in PDCD4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	61-64
23272133-10	2012	MiR-21 expression in these cells appeared to be dependent on Akt, as LY294002 reduced the levels of miR-21 along with a concurrent increase in PDCD4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	microRNA 21	Homo sapiens	100-106
22438954-9	2012	Finally, our data indicated that CAR treatment increased the level of phosphorylated Akt and the neuroprotection of CAR was reversed by a PI3K inhibitor LY-294002, demonstrating the involvement of the PI3K/Akt pathway in the anti-apoptotic mechanisms of CAR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-162	thymoma viral proto-oncogene 1	Mus musculus	85-88
23185517-8	2012	Using MK-2206 in combination with rapamycin (mTORC1 inhibitor), LY294002 (PI3K inhibitor), or U0126 (MEK1/2 inhibitor), we show that Erk- mediated downstream activation of PI3K/Akt pathway results in resistance to Akt inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	mitogen-activated protein kinase 1	Homo sapiens	133-136
23144836-7	2012	Treatment with CSC increased the concentration of phosphorylated Akt, while addition of the PI3K inhibitor LY294002 blocked doxorubicin extrusion, suggesting that Akt activation is required for CSC-induced drug efflux.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	AKT serine/threonine kinase 1	Homo sapiens	163-166
23049865-5	2012	Using LY294002 (a PI3K inhibitor) and Akt inhibitor IV, we showed that the regulation of enzyme activities and protein expressions of the RCs was dependent on PI3K/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	thymoma viral proto-oncogene 1	Mus musculus	164-167
22879882-5	2012	Pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented activation of spinal AKT induced by ephrinB1-Fc.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	88-91
22879882-5	2012	Pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented activation of spinal AKT induced by ephrinB1-Fc.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	ephrin B1	Homo sapiens	103-111
22879882-8	2012	Furthermore, pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented ephrinB1-Fc-induced ERK activation in spinal.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	ephrin B1	Homo sapiens	80-88
22879882-8	2012	Furthermore, pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented ephrinB1-Fc-induced ERK activation in spinal.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	mitogen-activated protein kinase 1	Homo sapiens	100-103
22675553-6	2012	Pretreatment of osteoblasts with PI3K inhibitor (Ly294002), Akt inhibitor, c-Src inhibitor (PP2), or AP-1 inhibitor (curcumin) blocked the potentiating action of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	hepatocyte growth factor	Homo sapiens	162-165
22675553-9	2012	HGF-mediated AP-1-luciferase activity and c-Jun binding to the AP-1 element was reduced by c-Met inhibitor, Ly294002, Akt inhibitor, and PP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	hepatocyte growth factor	Homo sapiens	0-3
22675553-9	2012	HGF-mediated AP-1-luciferase activity and c-Jun binding to the AP-1 element was reduced by c-Met inhibitor, Ly294002, Akt inhibitor, and PP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-47
23209838-5	2012	Pretreatment with PI3K inhibitor (Ly294002), Akt inhibitor, or mTORC1 inhibitor (rapamycin) blocked the HGF-induced VEGF-A production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	hepatocyte growth factor	Homo sapiens	104-107
23209838-5	2012	Pretreatment with PI3K inhibitor (Ly294002), Akt inhibitor, or mTORC1 inhibitor (rapamycin) blocked the HGF-induced VEGF-A production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	vascular endothelial growth factor A	Homo sapiens	116-122
22911870-11	2012	Furthermore, recombinant mouse periostin directly induced Col1alpha1 expression in vitro, and this effect was inhibited by blocking the alphav integrin-mediated PI3K/Akt signaling either with anti-alphav functional blocking antibody or with the PI3K/Akt kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	271-279	periostin, osteoblast specific factor	Mus musculus	31-40
22792172-11	2012	Phosphatidylinositol 3-kinase (PI3K) activity and Akt-Ser(473) phosphorylation were both increased by IGFBP-3 and selectively blocked by the SRB1-Ab or PI3K blocker LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	insulin-like growth factor binding protein 3	Mus musculus	102-109
22792172-11	2012	Phosphatidylinositol 3-kinase (PI3K) activity and Akt-Ser(473) phosphorylation were both increased by IGFBP-3 and selectively blocked by the SRB1-Ab or PI3K blocker LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	scavenger receptor class B, member 1	Mus musculus	141-145
22761812-7	2012	The inhibitors of PI3K-AKT and ERK1/2 pathways, LY294002 and U0126, both significantly suppressed EMT and CSC phenotype, indicating that AKT and ERK1/2 pathways are required for miR-21 mediating EMT and CSC phenotype.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	137-140
22761812-7	2012	The inhibitors of PI3K-AKT and ERK1/2 pathways, LY294002 and U0126, both significantly suppressed EMT and CSC phenotype, indicating that AKT and ERK1/2 pathways are required for miR-21 mediating EMT and CSC phenotype.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	microRNA 21	Homo sapiens	178-184
22545124-8	2012	Western Blotting results showed that stimulation of NSPCs with Sal B enhanced the phosphorylation of Akt, and Ly294002 abolished this effect, confirming the role of Akt in Sal B mediated proliferation of NSPCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Rattus norvegicus	165-168
22438954-9	2012	Finally, our data indicated that CAR treatment increased the level of phosphorylated Akt and the neuroprotection of CAR was reversed by a PI3K inhibitor LY-294002, demonstrating the involvement of the PI3K/Akt pathway in the anti-apoptotic mechanisms of CAR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-162	thymoma viral proto-oncogene 1	Mus musculus	206-209
22355314-5	2012	Using AG1295 (a PDGFR kinase inhibitor), LY294002 (a PI3K inhibitor), and sc-221226 (an Akt inhibitor), we further showed that the PI3K/Akt signaling pathway participates in the PDGF-BB-induced proliferation, migration, and angiogenesis of EPCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	136-139
22281081-6	2012	Inhibition of PI3-K with LY294002 significantly decreased the expression of HK-I, PFK-1, GAPDH, GSK-3A/B and GLUT-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	hexokinase 1	Bos taurus	76-80
22242160-9	2012	The HGF-induced, LY294002-sensitive translocation of PKCzeta from cytosol to plasma membrane indicated that HGF was capable of activating PKCzeta, probably via phosphoinositide (PI) 3-kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	hepatocyte growth factor	Homo sapiens	4-7
22242160-9	2012	The HGF-induced, LY294002-sensitive translocation of PKCzeta from cytosol to plasma membrane indicated that HGF was capable of activating PKCzeta, probably via phosphoinositide (PI) 3-kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	protein kinase C zeta	Homo sapiens	53-60
22242160-9	2012	The HGF-induced, LY294002-sensitive translocation of PKCzeta from cytosol to plasma membrane indicated that HGF was capable of activating PKCzeta, probably via phosphoinositide (PI) 3-kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	hepatocyte growth factor	Homo sapiens	108-111
22242160-9	2012	The HGF-induced, LY294002-sensitive translocation of PKCzeta from cytosol to plasma membrane indicated that HGF was capable of activating PKCzeta, probably via phosphoinositide (PI) 3-kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	protein kinase C zeta	Homo sapiens	138-145
22272284-4	2012	Protection against ischemia/reperfusion injury was assessed using isolated perfused hearts where alpha-MHC-tTA mice had robust protection against ischemia/reperfusion injury which was not blocked by pharmacological inhibition of PI3Ks with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	240-248	myosin, heavy polypeptide 6, cardiac muscle, alpha	Mus musculus	97-106
22281081-6	2012	Inhibition of PI3-K with LY294002 significantly decreased the expression of HK-I, PFK-1, GAPDH, GSK-3A/B and GLUT-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	glyceraldehyde-3-phosphate dehydrogenase	Bos taurus	89-94
22281081-6	2012	Inhibition of PI3-K with LY294002 significantly decreased the expression of HK-I, PFK-1, GAPDH, GSK-3A/B and GLUT-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	glycogen synthase kinase 3 alpha	Bos taurus	96-104
22281081-6	2012	Inhibition of PI3-K with LY294002 significantly decreased the expression of HK-I, PFK-1, GAPDH, GSK-3A/B and GLUT-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	solute carrier family 2 member 1	Bos taurus	109-115
22040798-13	2011	The isoflurane postconditioning-induced protection in the neuronal cultures was decreased by the Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
22208359-9	2011	Furthermore, Ad-IRF3 activated Akt, and LY294002 reversed the effects of Ad-IRF3 on microglial inflammatory gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	interferon regulatory factor 3	Homo sapiens	76-80
22040922-8	2011	Moreover, treatment of LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, had similar effects than that of tangeretin on the expression of p27(kip1) and cyclin D1, as well as cell migration in PDFG-BB-stimulated RASMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	35-60
22040922-8	2011	Moreover, treatment of LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, had similar effects than that of tangeretin on the expression of p27(kip1) and cyclin D1, as well as cell migration in PDFG-BB-stimulated RASMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	144-147
22040922-8	2011	Moreover, treatment of LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, had similar effects than that of tangeretin on the expression of p27(kip1) and cyclin D1, as well as cell migration in PDFG-BB-stimulated RASMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	148-152
22040922-8	2011	Moreover, treatment of LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, had similar effects than that of tangeretin on the expression of p27(kip1) and cyclin D1, as well as cell migration in PDFG-BB-stimulated RASMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	cyclin D1	Rattus norvegicus	158-167
22185378-8	2011	Matuzumab exhibited a synergic effect with LY294002, leading to a reduction of Akt phosphorylation that was followed by a decrease in A431 and Caski cells survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	79-82
22019741-6	2011	The phosphorylation of extracellular regulating protein kinase (Erk) and Akt can be induced by the administration of 50muM deprenyl in PC12 cells, and the ability of deprenyl to enhance NQO1 expression and Nrf2 nuclear translocation is partly attenuated by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 and is almost completely attenuated by the phosphatidyl-inositol 3 kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	416-424	Eph receptor B1	Rattus norvegicus	23-62
22019741-6	2011	The phosphorylation of extracellular regulating protein kinase (Erk) and Akt can be induced by the administration of 50muM deprenyl in PC12 cells, and the ability of deprenyl to enhance NQO1 expression and Nrf2 nuclear translocation is partly attenuated by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 and is almost completely attenuated by the phosphatidyl-inositol 3 kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	416-424	Eph receptor B1	Rattus norvegicus	64-67
22019741-6	2011	The phosphorylation of extracellular regulating protein kinase (Erk) and Akt can be induced by the administration of 50muM deprenyl in PC12 cells, and the ability of deprenyl to enhance NQO1 expression and Nrf2 nuclear translocation is partly attenuated by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 and is almost completely attenuated by the phosphatidyl-inositol 3 kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	416-424	AKT serine/threonine kinase 1	Rattus norvegicus	73-76
21964931-9	2011	The use of small molecule inhibitors LY294002 or rapamycin to inhibit PI3K/Akt and p70(S6K) activities, respectively, resulted in diminished HIF-1alpha activation and subsequent VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	75-78
22139028-11	2011	Pretreatment with the specific PI3K inhibitor LY294002 (10 mumol/L) blocked NGF-stimulated Akt phosphorylation, tube formation and angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
22146375-9	2011	By contrast, the enhancing effect of BDNF on EGF-induced proliferation and migration of NSPCs were abolished by an inhibitor of PI3K, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	brain derived neurotrophic factor	Homo sapiens	37-41
21964931-9	2011	The use of small molecule inhibitors LY294002 or rapamycin to inhibit PI3K/Akt and p70(S6K) activities, respectively, resulted in diminished HIF-1alpha activation and subsequent VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	ribosomal protein S6 kinase B1	Homo sapiens	83-86
21964931-9	2011	The use of small molecule inhibitors LY294002 or rapamycin to inhibit PI3K/Akt and p70(S6K) activities, respectively, resulted in diminished HIF-1alpha activation and subsequent VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-151
21964931-9	2011	The use of small molecule inhibitors LY294002 or rapamycin to inhibit PI3K/Akt and p70(S6K) activities, respectively, resulted in diminished HIF-1alpha activation and subsequent VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	vascular endothelial growth factor A	Homo sapiens	178-182
21889928-8	2011	Importantly, co-treatment with MEK/ERK inhibitor (U0126) and PI3K/Akt (LY294002) or mTOR (rapamycin) inhibitors, instead of ATO, also potentiates lonidamine-provoked apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Homo sapiens	66-69
21922126-7	2011	The p38 MAPK inhibitor SB203580 and the PI3K inhibitor LY294002 significantly reduced the IL-beta-induced IL-24 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	interleukin 24	Homo sapiens	106-111
21948177-6	2011	Pretreatment with a phosphatidylinositol 3" kinase (PI3K) inhibitor, LY294002, partly reversed adiponectin"s anti-apoptotic effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	adiponectin, C1Q and collagen domain containing	Homo sapiens	95-106
21885991-9	2011	Up4A also increased the phosphorylation of Akt, which was blocked by the PI3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	43-46
20628892-7	2011	Akt signaling was inhibited by the upstream kinase inhibitors, LY294002, Wortmannin, as well as by the specific Akt Inhibitor VIII in all three hepatoma cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	AKT serine/threonine kinase 1	Homo sapiens	0-3
21885991-10	2011	Up4A-stimulated activation of S6K, but not Erk1/2, was also prevented by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	ribosomal protein S6 kinase B1	Homo sapiens	30-33
21990425-9	2011	Autophagy inhibition by 3"-methyladenine, LY294002, wortmannin or by knockdown of Beclin-1 or Atg 7 inhibited MCPIP-induced expression of OC markers.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	zinc finger CCCH-type containing 12A	Homo sapiens	110-115
21909975-5	2011	These inhibitory effects of IMD(1-53) were abolished by the IMD receptor antagonist IMD(17-47) (10(-6) mol/l) and phosphoinositide 3-kinase inhibitor LY294002 (10 mumol/l).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	adrenomedullin 2	Rattus norvegicus	28-31
21822619-10	2011	Furthermore, a PI3 kinase inhibitor (LY294002) but not a PKC inhibitor (Ro318220) significantly diminished p38 MAPK phosphorylation; nevertheless, a p38 MAPK inhibitor (SB203580) and LY294002 diminished PKC activity stimulated by collagen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	mitogen-activated protein kinase 14	Mus musculus	107-110
21822619-10	2011	Furthermore, a PI3 kinase inhibitor (LY294002) but not a PKC inhibitor (Ro318220) significantly diminished p38 MAPK phosphorylation; nevertheless, a p38 MAPK inhibitor (SB203580) and LY294002 diminished PKC activity stimulated by collagen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	mitogen-activated protein kinase 14	Mus musculus	107-115
21989390-7	2011	Further experiments revealed that all types of LAs activated cell survival-associated kinase Akt, and an inhibitor of PI3K, LY294002, suppressed both LA-induced upregulation of NQO1 and cell protection against BSO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	NAD(P)H quinone dehydrogenase 1	Homo sapiens	177-181
21874266-4	2011	This downregulation             was blocked by the proteasome inhibitor MG132 and the Akt-specific inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	AKT serine/threonine kinase 1	Rattus norvegicus	86-89
21683736-10	2011	Pretreatment with LY294002, a phosphatidylinositol 3-kinase inhibitor, prior to combined treatment with EPO and L-DOPA almost completely blocked the protective effects of EPO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	erythropoietin	Rattus norvegicus	104-107
21683736-10	2011	Pretreatment with LY294002, a phosphatidylinositol 3-kinase inhibitor, prior to combined treatment with EPO and L-DOPA almost completely blocked the protective effects of EPO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	erythropoietin	Rattus norvegicus	171-174
21850380-10	2011	Inhibition of Akt with LY294002 completely prevented the LMP1-induced FLIP             expression and TRAIL resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	14-17
22509540-6	2011	RESULTS: Cells in EGF group had significantly stronger migration ability than in control group (P = 0.0361), inhibitor AG1478 + EGF group (P = 0.0113), inhibitor LY294002 + EGF group (P = 0.0169), and inhibitor U0126 + EGF group (P = 0.0293).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	epidermal growth factor	Homo sapiens	18-21
21850380-10	2011	Inhibition of Akt with LY294002 completely prevented the LMP1-induced FLIP             expression and TRAIL resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	PDZ and LIM domain 7	Homo sapiens	57-61
21850380-10	2011	Inhibition of Akt with LY294002 completely prevented the LMP1-induced FLIP             expression and TRAIL resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	TNF superfamily member 10	Homo sapiens	102-107
21993263-3	2011	Selective 5-HT(2A) receptor agonist, DOI, induced JEG-3 cell growth was inhibited by the inhibitor of JAK2 (AG490), MEK1/2 (U0126), phospholipase C-beta (PLC-beta; U73122) and protein kinase C-beta (PKC-beta; Go6976)), whereas the selective phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	289-297	5-hydroxytryptamine receptor 2A	Homo sapiens	10-27
21993263-3	2011	Selective 5-HT(2A) receptor agonist, DOI, induced JEG-3 cell growth was inhibited by the inhibitor of JAK2 (AG490), MEK1/2 (U0126), phospholipase C-beta (PLC-beta; U73122) and protein kinase C-beta (PKC-beta; Go6976)), whereas the selective phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	289-297	Janus kinase 2	Homo sapiens	102-106
21782929-4	2011	Luteolin significantly increased the viability of MC3T3-E1 cells in the presence of AMA and the effect of luteolin in increasing cell viability was completely prevented by the presence of LY294002, Akt inhibitor, or auranofin, suggesting that the effect of luteolin might be partly mediated from PI3K, Akt, and thioredoxin reductase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	thymoma viral proto-oncogene 1	Mus musculus	302-305
21536059-4	2011	Specifically, apoE induced the phosphorylation of Akt, peaking at 30 min, and the increased phosphorylation of Akt was significantly attenuated after pretreatment with LY294002 (50 muM), an inhibitor of the PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	apolipoprotein E	Rattus norvegicus	14-18
22509540-8	2011	However, the increased expressions of P-AKT and P-ERK could be suppressed by AG1478 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Homo sapiens	40-43
21536059-4	2011	Specifically, apoE induced the phosphorylation of Akt, peaking at 30 min, and the increased phosphorylation of Akt was significantly attenuated after pretreatment with LY294002 (50 muM), an inhibitor of the PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	AKT serine/threonine kinase 1	Rattus norvegicus	50-53
21536059-4	2011	Specifically, apoE induced the phosphorylation of Akt, peaking at 30 min, and the increased phosphorylation of Akt was significantly attenuated after pretreatment with LY294002 (50 muM), an inhibitor of the PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	AKT serine/threonine kinase 1	Rattus norvegicus	111-114
21536059-7	2011	Pretreatment with LY294002 significantly attenuated the potency of exogenous apoE to induce satiation, while the same dose of PI3K inhibitor by itself caused only a slight non-significant decrease of food intake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	apolipoprotein E	Rattus norvegicus	77-81
21904110-6	2011	Treatment with TNF-alpha resulted in a strong increase in the phosphorylation of Akt on Ser-473 and when cells were treated with phosphatidylinositol (PI) 3-kinase inhibitors such as LY294002 or wortmannin, or Akt inhibitor (Akt inhibitor IV), induction of STS mRNA expression by TNF-alpha was significantly prevented.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	tumor necrosis factor	Homo sapiens	15-24
21904110-6	2011	Treatment with TNF-alpha resulted in a strong increase in the phosphorylation of Akt on Ser-473 and when cells were treated with phosphatidylinositol (PI) 3-kinase inhibitors such as LY294002 or wortmannin, or Akt inhibitor (Akt inhibitor IV), induction of STS mRNA expression by TNF-alpha was significantly prevented.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	AKT serine/threonine kinase 1	Homo sapiens	81-84
22509540-8	2011	However, the increased expressions of P-AKT and P-ERK could be suppressed by AG1478 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	mitogen-activated protein kinase 1	Homo sapiens	50-53
22156391-9	2011	Also, NAC, LY294002, U0126, GSK733, which all indirectly inhibit mTOR and have been shown to suppress the senescent phenotype in traditional models of mammalian cell senescence, also decreased lactate production and decelerated CS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	mechanistic target of rapamycin kinase	Homo sapiens	65-69
22026410-4	2011	In addition, 1 and LY294002 blocked TNF-alpha-induced IkappaB-alpha degradation and nuclear p65 protein accumulation, as well as the DNA-binding activity of NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	tumor necrosis factor	Homo sapiens	36-45
22026410-4	2011	In addition, 1 and LY294002 blocked TNF-alpha-induced IkappaB-alpha degradation and nuclear p65 protein accumulation, as well as the DNA-binding activity of NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	NFKB inhibitor alpha	Homo sapiens	54-67
22026410-4	2011	In addition, 1 and LY294002 blocked TNF-alpha-induced IkappaB-alpha degradation and nuclear p65 protein accumulation, as well as the DNA-binding activity of NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	RELA proto-oncogene, NF-kB subunit	Homo sapiens	92-95
21906719-7	2011	LY294002 inhibited TSP-1-induced and E3T3C1-induced (P &lt; .05) but not NH(2)-induced or 3TSR-induced (P &gt; .05) chemotaxis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thrombospondin 1	Homo sapiens	19-24
21832246-4	2011	Abrogation of basal IGF-I signaling, using LY294002, resulted in a prominent induction of atrogin-1 and MuRF1 mRNA and was accompanied by a loss of myosin heavy chain fast (MyHC-f) and myosin light chains 1 (MyLC-1) and -3 (MyLC-3).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	insulin like growth factor 1	Homo sapiens	20-25
21832246-4	2011	Abrogation of basal IGF-I signaling, using LY294002, resulted in a prominent induction of atrogin-1 and MuRF1 mRNA and was accompanied by a loss of myosin heavy chain fast (MyHC-f) and myosin light chains 1 (MyLC-1) and -3 (MyLC-3).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	F-box protein 32	Homo sapiens	90-99
21832246-4	2011	Abrogation of basal IGF-I signaling, using LY294002, resulted in a prominent induction of atrogin-1 and MuRF1 mRNA and was accompanied by a loss of myosin heavy chain fast (MyHC-f) and myosin light chains 1 (MyLC-1) and -3 (MyLC-3).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	tripartite motif containing 63	Homo sapiens	104-109
21832246-7	2011	Interestingly, loss of endogenous GSK-3beta suppressed both basal and atrophy stimulus-induced atrogin-1 and MuRF1 expression, whereas pharmacological GSK-3beta inhibition, using CHIR99021 or LiCl, only reduced atrogin-1 mRNA levels in response to LY294002 or Dex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	248-256	glycogen synthase kinase 3 beta	Homo sapiens	34-43
21948550-6	2011	RESULTS: FGF-2 stimulated cell proliferation in hCECs; the FGF-2 action was completely blocked by pathway-specific inhibitors for PI 3-kinase (LY294002) and MEK1/2 (U0126), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	fibroblast growth factor 2	Homo sapiens	9-14
21841492-6	2011	LY294002 reversed insulin-mediated downregulation of tumor necrosis factor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor-like	Rattus norvegicus	53-74
21904903-5	2011	Signaling transduction inhibitors, LY294002 and PD98059, were used to block PI3K/Akt and MAPK/ERK1/2 signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	81-84
21904903-5	2011	Signaling transduction inhibitors, LY294002 and PD98059, were used to block PI3K/Akt and MAPK/ERK1/2 signaling pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	mitogen-activated protein kinase 3	Homo sapiens	94-100
21878657-8	2011	IGF1R-induced gefitinib resistance was unaffected by MAP/Erk kinase inhibition with U0126 but was partially impaired by inhibition of phosphoinositide-3-kinase with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	insulin like growth factor 1 receptor	Homo sapiens	0-5
21854819-5	2011	The insulin-induced increase of tau protein level was abolished by LY294002 [an inhibitor of phosphoinositide 3-kinase (PI3K)] and rapamycin [an inhibitor of mammalian target of rapamycin (mTOR)], but not by PD98059 and U0126 [two inhibitors of mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK)].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	insulin	Homo sapiens	4-11
21854819-5	2011	The insulin-induced increase of tau protein level was abolished by LY294002 [an inhibitor of phosphoinositide 3-kinase (PI3K)] and rapamycin [an inhibitor of mammalian target of rapamycin (mTOR)], but not by PD98059 and U0126 [two inhibitors of mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK)].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	93-118
21807062-7	2011	Furthermore, the p38 inhibitor SB203580 and the Akt inhibitor LY294002 also decreased the effect of retinol on RAGE levels, suggesting the involvement of these protein kinases in such effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	AKT serine/threonine kinase 1	Homo sapiens	48-51
21807062-7	2011	Furthermore, the p38 inhibitor SB203580 and the Akt inhibitor LY294002 also decreased the effect of retinol on RAGE levels, suggesting the involvement of these protein kinases in such effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	advanced glycosylation end-product specific receptor	Homo sapiens	111-115
22340244-4	2011	LY294002 and AMD3100 were used to interfere with the signaling of VEGF and SDF-1alpha/CXCR4 axis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	vascular endothelial growth factor A	Rattus norvegicus	66-70
22340244-4	2011	LY294002 and AMD3100 were used to interfere with the signaling of VEGF and SDF-1alpha/CXCR4 axis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine receptor 4	Rattus norvegicus	86-91
22340244-8	2011	The phosphoinositol-3-kinase (PI3K) inhibitor, LY294002 and Flk-1 antibody abolished the beneficial effects of VEGF on H2O2 induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	vascular endothelial growth factor A	Rattus norvegicus	111-115
22340244-10	2011	Interestingly, SDF-1alpha also promoted production of VEGF in cultured cardiac myocytes and LY294002 reversed the up-regulation of VEGF induced by SDF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	vascular endothelial growth factor A	Rattus norvegicus	131-135
21641013-10	2011	LY294002 and RAD001 significantly reduced AKT activity and cell viability and induced a G(1) cell cycle arrest.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	42-45
21904903-8	2011	Remarkably, inhibition of Akt phosphorylation by LY294002 completely blocked the effects on IGF-1-induced VEGF-C up-regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	26-29
21904903-8	2011	Remarkably, inhibition of Akt phosphorylation by LY294002 completely blocked the effects on IGF-1-induced VEGF-C up-regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	insulin like growth factor 1	Homo sapiens	92-97
21904903-8	2011	Remarkably, inhibition of Akt phosphorylation by LY294002 completely blocked the effects on IGF-1-induced VEGF-C up-regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	vascular endothelial growth factor C	Homo sapiens	106-112
21935931-7	2011	Our results also demonstrate that the AKT signaling pathway is involved in the regulation of Jab1 by Bcr-Abl because the AKT inhibitor LY294002 but not the ERK inhibitor PD98059 reduces Jab1 promoter activity and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Homo sapiens	38-41
21935931-7	2011	Our results also demonstrate that the AKT signaling pathway is involved in the regulation of Jab1 by Bcr-Abl because the AKT inhibitor LY294002 but not the ERK inhibitor PD98059 reduces Jab1 promoter activity and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	COP9 signalosome subunit 5	Homo sapiens	93-97
21935931-7	2011	Our results also demonstrate that the AKT signaling pathway is involved in the regulation of Jab1 by Bcr-Abl because the AKT inhibitor LY294002 but not the ERK inhibitor PD98059 reduces Jab1 promoter activity and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	101-108
21935931-7	2011	Our results also demonstrate that the AKT signaling pathway is involved in the regulation of Jab1 by Bcr-Abl because the AKT inhibitor LY294002 but not the ERK inhibitor PD98059 reduces Jab1 promoter activity and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Homo sapiens	121-124
21935931-7	2011	Our results also demonstrate that the AKT signaling pathway is involved in the regulation of Jab1 by Bcr-Abl because the AKT inhibitor LY294002 but not the ERK inhibitor PD98059 reduces Jab1 promoter activity and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	COP9 signalosome subunit 5	Homo sapiens	186-190
21854819-5	2011	The insulin-induced increase of tau protein level was abolished by LY294002 [an inhibitor of phosphoinositide 3-kinase (PI3K)] and rapamycin [an inhibitor of mammalian target of rapamycin (mTOR)], but not by PD98059 and U0126 [two inhibitors of mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK)].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	mechanistic target of rapamycin kinase	Homo sapiens	189-193
21854819-5	2011	The insulin-induced increase of tau protein level was abolished by LY294002 [an inhibitor of phosphoinositide 3-kinase (PI3K)] and rapamycin [an inhibitor of mammalian target of rapamycin (mTOR)], but not by PD98059 and U0126 [two inhibitors of mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK)].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	mitogen-activated protein kinase kinase 7	Homo sapiens	317-320
21867737-5	2011	Pre-treatment of the PI3K inhibitor LY294002, 20min prior to Post C, significantly attenuated Post C-induced elevation of p-Akt and p-GSK3beta, as well as prevented Post C enhancement of mitochondrial integrity and Post C neuroprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	124-127
21867737-5	2011	Pre-treatment of the PI3K inhibitor LY294002, 20min prior to Post C, significantly attenuated Post C-induced elevation of p-Akt and p-GSK3beta, as well as prevented Post C enhancement of mitochondrial integrity and Post C neuroprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	glycogen synthase kinase 3 beta	Homo sapiens	134-142
21948550-6	2011	RESULTS: FGF-2 stimulated cell proliferation in hCECs; the FGF-2 action was completely blocked by pathway-specific inhibitors for PI 3-kinase (LY294002) and MEK1/2 (U0126), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	fibroblast growth factor 2	Homo sapiens	59-64
21948550-9	2011	The authors then determined cross-talk between PI 3-kinase and extracellular signal-regulated kinase (ERK)1/2; blocking of ERK1/2 activation by LY294002 indicated that in hCECs ERK1/2 works as a downstream effector to PI 3-kinase for cell proliferation induced by FGF-2, whereas the ERK1/2 pathway in rCECs is parallel to the PI 3-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	mitogen-activated protein kinase 3	Homo sapiens	123-129
21948550-9	2011	The authors then determined cross-talk between PI 3-kinase and extracellular signal-regulated kinase (ERK)1/2; blocking of ERK1/2 activation by LY294002 indicated that in hCECs ERK1/2 works as a downstream effector to PI 3-kinase for cell proliferation induced by FGF-2, whereas the ERK1/2 pathway in rCECs is parallel to the PI 3-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	mitogen-activated protein kinase 3	Homo sapiens	177-183
21948550-9	2011	The authors then determined cross-talk between PI 3-kinase and extracellular signal-regulated kinase (ERK)1/2; blocking of ERK1/2 activation by LY294002 indicated that in hCECs ERK1/2 works as a downstream effector to PI 3-kinase for cell proliferation induced by FGF-2, whereas the ERK1/2 pathway in rCECs is parallel to the PI 3-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	mitogen-activated protein kinase 3	Homo sapiens	177-183
21816215-8	2011	The specific MEK/ERK inhibitor PD98059 and PI3K/Akt inhibitor LY294002, block the PPNC-induced hypopigmentation effect, and abrogate the PPNC-suppressed expression of melanogenic proteins such as MITF, tyrosinase, TRP-1, and Dct.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	thymoma viral proto-oncogene 1	Mus musculus	48-51
21816215-8	2011	The specific MEK/ERK inhibitor PD98059 and PI3K/Akt inhibitor LY294002, block the PPNC-induced hypopigmentation effect, and abrogate the PPNC-suppressed expression of melanogenic proteins such as MITF, tyrosinase, TRP-1, and Dct.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	melanogenesis associated transcription factor	Mus musculus	196-200
21803945-12	2011	Supplementation with the phosphoinositide 3-kinase/Akt inhibitor LY-294002 during the late stage of differentiation was found to partially restore myofibrillogenesis while suppressing the increase in size of individual mature cardiomyocytes derived from the SHP2-Q510E mutants.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-74	thymoma viral proto-oncogene 1	Mus musculus	51-54
21712532-9	2011	Akt Thr(308) and Ser(473) phosphorylation were enhanced following OGT shRNA expression in high-glucose-exposed mesangial cells, but high-glucose-induced p38 phosphorylation was not attenuated by OGT shRNA in cells pretreated with the phosphatidylinositol 3-kinase inhibitor LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	274-283	AKT serine/threonine kinase 1	Rattus norvegicus	0-3
21803945-12	2011	Supplementation with the phosphoinositide 3-kinase/Akt inhibitor LY-294002 during the late stage of differentiation was found to partially restore myofibrillogenesis while suppressing the increase in size of individual mature cardiomyocytes derived from the SHP2-Q510E mutants.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-74	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	258-262
21872252-7	2011	Blocking assays using the neutralizing antibody for vascular endothelial growth factor (VEGF) and the specific inhibitor of phosphoinositide 3-kinase (PI3K), such as LY294002 or wortmannin, demonstrated that the protective effect of CREG on ECs apoptosis was mainly mediated by activation of the VEGF/PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	vascular endothelial growth factor A	Mus musculus	52-86
21872252-7	2011	Blocking assays using the neutralizing antibody for vascular endothelial growth factor (VEGF) and the specific inhibitor of phosphoinositide 3-kinase (PI3K), such as LY294002 or wortmannin, demonstrated that the protective effect of CREG on ECs apoptosis was mainly mediated by activation of the VEGF/PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	124-149
21872252-7	2011	Blocking assays using the neutralizing antibody for vascular endothelial growth factor (VEGF) and the specific inhibitor of phosphoinositide 3-kinase (PI3K), such as LY294002 or wortmannin, demonstrated that the protective effect of CREG on ECs apoptosis was mainly mediated by activation of the VEGF/PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	vascular endothelial growth factor A	Mus musculus	296-300
21872252-7	2011	Blocking assays using the neutralizing antibody for vascular endothelial growth factor (VEGF) and the specific inhibitor of phosphoinositide 3-kinase (PI3K), such as LY294002 or wortmannin, demonstrated that the protective effect of CREG on ECs apoptosis was mainly mediated by activation of the VEGF/PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	thymoma viral proto-oncogene 1	Mus musculus	306-309
21620963-10	2011	The protective effect of Epo on RPE barrier function was completely blocked by AG490 and almost completely abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	erythropoietin	Homo sapiens	25-28
21763292-9	2011	In addition, LY294002, a PI3K inhibitor, and SB203580, a p38 MAPK inhibitor, significantly inhibited not only HO-1 induction but also HMGB1 release by ISO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	heme oxygenase 1	Mus musculus	110-114
21763292-9	2011	In addition, LY294002, a PI3K inhibitor, and SB203580, a p38 MAPK inhibitor, significantly inhibited not only HO-1 induction but also HMGB1 release by ISO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	high mobility group box 1	Mus musculus	134-139
21553247-8	2011	In addition, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, LY294002, attenuated the antiapoptotic effect of BDNF on BIT/SHPS-1(WT)-, and BIT/SHPS-1(4F)-expressing cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	15-44
21553247-8	2011	In addition, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, LY294002, attenuated the antiapoptotic effect of BDNF on BIT/SHPS-1(WT)-, and BIT/SHPS-1(4F)-expressing cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	brain-derived neurotrophic factor	Rattus norvegicus	113-117
21770712-5	2011	Furthermore, we demonstrated for the first time that the brain-specific blockade of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, by intranasal administration of LY294002, a specific inhibitor of PI3K/Akt signaling pathway, significantly blocked acupuncture-induced dopaminergic neuron protection and motor function improvement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	84-113
21553247-8	2011	In addition, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, LY294002, attenuated the antiapoptotic effect of BDNF on BIT/SHPS-1(WT)-, and BIT/SHPS-1(4F)-expressing cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	signal-regulatory protein alpha	Rattus norvegicus	121-124
21553247-8	2011	In addition, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, LY294002, attenuated the antiapoptotic effect of BDNF on BIT/SHPS-1(WT)-, and BIT/SHPS-1(4F)-expressing cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	signal-regulatory protein alpha	Rattus norvegicus	125-135
21553247-8	2011	In addition, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, LY294002, attenuated the antiapoptotic effect of BDNF on BIT/SHPS-1(WT)-, and BIT/SHPS-1(4F)-expressing cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	signal-regulatory protein alpha	Rattus norvegicus	142-145
21553247-8	2011	In addition, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, LY294002, attenuated the antiapoptotic effect of BDNF on BIT/SHPS-1(WT)-, and BIT/SHPS-1(4F)-expressing cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	signal-regulatory protein alpha	Rattus norvegicus	125-131
21770712-5	2011	Furthermore, we demonstrated for the first time that the brain-specific blockade of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, by intranasal administration of LY294002, a specific inhibitor of PI3K/Akt signaling pathway, significantly blocked acupuncture-induced dopaminergic neuron protection and motor function improvement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	thymoma viral proto-oncogene 1	Mus musculus	121-124
21770712-5	2011	Furthermore, we demonstrated for the first time that the brain-specific blockade of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, by intranasal administration of LY294002, a specific inhibitor of PI3K/Akt signaling pathway, significantly blocked acupuncture-induced dopaminergic neuron protection and motor function improvement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	thymoma viral proto-oncogene 1	Mus musculus	215-218
21697727-7	2011	In mRen2.Lewis, but not in control Lewis rats, LY294002 (50 mumole/L) reduced MAP and increased BRS and HRV similar to wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	renin 2 tandem duplication of Ren1	Mus musculus	3-8
20464445-7	2011	The combination of simvastatin and 10 muM LY294002 (non-toxic dose) augmented apoptosis significantly, as evidenced by cleavage of PARP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	collagen type XI alpha 2 chain	Homo sapiens	131-135
21757005-7	2011	Inhibitors of GSK3beta (lithium) and p38 MAPK (SB203580) signaling pathways restored the depressed histone acetylation and Nrf2-related transcription whereas an inhibitor of Akt (Ly294002) caused a further decrease in Nrf2-related transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	AKT serine/threonine kinase 1	Homo sapiens	174-177
21904878-8	2011	Lowering the phospho-Akt level by HNMPA or LY294002, a PI3K inhibitor, further augmented exe-4-induced cAMP formation and Erk phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	21-24
21904878-8	2011	Lowering the phospho-Akt level by HNMPA or LY294002, a PI3K inhibitor, further augmented exe-4-induced cAMP formation and Erk phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	EPH receptor B2	Homo sapiens	122-125
21757005-7	2011	Inhibitors of GSK3beta (lithium) and p38 MAPK (SB203580) signaling pathways restored the depressed histone acetylation and Nrf2-related transcription whereas an inhibitor of Akt (Ly294002) caused a further decrease in Nrf2-related transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	NFE2 like bZIP transcription factor 2	Homo sapiens	218-222
21512969-6	2011	In BV-2 cells, OGD induced ROS and nitric oxide production by upregulating NOX2 and iNOS via the phosphatidylinositol-3-kinase (PI3K)/AKT-dependent NF- kappaB and HIF-1 alpha pathways, and these changes were suppressed by andrographolide and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	cytochrome b-245, beta polypeptide	Mus musculus	75-79
22026163-12	2011	Furthermore, the PI3K inhibitor LY294002 significantly abolished the anti-apoptotic effect of ibrolipim, and decreased Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	119-122
21512969-6	2011	In BV-2 cells, OGD induced ROS and nitric oxide production by upregulating NOX2 and iNOS via the phosphatidylinositol-3-kinase (PI3K)/AKT-dependent NF- kappaB and HIF-1 alpha pathways, and these changes were suppressed by andrographolide and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	nitric oxide synthase 2, inducible	Mus musculus	84-88
21512969-6	2011	In BV-2 cells, OGD induced ROS and nitric oxide production by upregulating NOX2 and iNOS via the phosphatidylinositol-3-kinase (PI3K)/AKT-dependent NF- kappaB and HIF-1 alpha pathways, and these changes were suppressed by andrographolide and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	97-126
21512969-6	2011	In BV-2 cells, OGD induced ROS and nitric oxide production by upregulating NOX2 and iNOS via the phosphatidylinositol-3-kinase (PI3K)/AKT-dependent NF- kappaB and HIF-1 alpha pathways, and these changes were suppressed by andrographolide and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	thymoma viral proto-oncogene 1	Mus musculus	134-137
21512969-6	2011	In BV-2 cells, OGD induced ROS and nitric oxide production by upregulating NOX2 and iNOS via the phosphatidylinositol-3-kinase (PI3K)/AKT-dependent NF- kappaB and HIF-1 alpha pathways, and these changes were suppressed by andrographolide and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	148-158
22321426-2	2011	METHODS: With cell growth assay, flow cytometric analysis and Western blotting, the effects of TRAIL and PI3-K-Akt special inhibitor (LY294002) on cell growth, apoptosis and related proteins expressions in CNE-2 cell lines were studied.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	AKT serine/threonine kinase 1	Homo sapiens	111-114
21321983-9	2011	Treatment with LY294002 at the same dose reduced the viability of C4-2AT6 more effectively than that of C4-2, reflecting the dependency of cancer cells on PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	thymoma viral proto-oncogene 1	Mus musculus	160-163
21321983-10	2011	The up-regulated AT1R expression in C4-2AT6 cells was reduced by LY294002 in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	angiotensin II, type I receptor-associated protein	Mus musculus	17-21
22000441-9	2011	CONCLUSIONS: PI3K inhibitor LY294002 can inhibit the differentiation of mouse 3T3-LI preadipocytes and the expression of C/EBPalpha and PPARgamma in the differentiation of 3T3-LI preadipoeytes, suggesting that IRSs/PI3K signal pathway may play an important role in the differentiation of 3T3-L1 preadipocytes by regulating the expression of C/EBPalpha and PPARgamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	121-131
22000441-9	2011	CONCLUSIONS: PI3K inhibitor LY294002 can inhibit the differentiation of mouse 3T3-LI preadipocytes and the expression of C/EBPalpha and PPARgamma in the differentiation of 3T3-LI preadipoeytes, suggesting that IRSs/PI3K signal pathway may play an important role in the differentiation of 3T3-L1 preadipocytes by regulating the expression of C/EBPalpha and PPARgamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	peroxisome proliferator activated receptor gamma	Mus musculus	136-145
22000441-9	2011	CONCLUSIONS: PI3K inhibitor LY294002 can inhibit the differentiation of mouse 3T3-LI preadipocytes and the expression of C/EBPalpha and PPARgamma in the differentiation of 3T3-LI preadipoeytes, suggesting that IRSs/PI3K signal pathway may play an important role in the differentiation of 3T3-L1 preadipocytes by regulating the expression of C/EBPalpha and PPARgamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	341-351
22000441-9	2011	CONCLUSIONS: PI3K inhibitor LY294002 can inhibit the differentiation of mouse 3T3-LI preadipocytes and the expression of C/EBPalpha and PPARgamma in the differentiation of 3T3-LI preadipoeytes, suggesting that IRSs/PI3K signal pathway may play an important role in the differentiation of 3T3-L1 preadipocytes by regulating the expression of C/EBPalpha and PPARgamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	peroxisome proliferator activated receptor gamma	Mus musculus	356-365
22000441-0	2011	[Effects of PI3K inhibitor LY294002 on the differentiation of mouse preadipocytes and the expression of C/EBPalpha and PPARgamma].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	peroxisome proliferator activated receptor gamma	Mus musculus	119-128
22321426-3	2011	RESULTS: When concentrate of TRAIL&gt;1 ng/ml, viability rate of cells in combinative treatment group with TRAIL and LY294002 was higher than that in the single treatment group with TRAIL (all P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	TNF superfamily member 10	Homo sapiens	29-34
21757754-11	2011	In contrast, inhibition of PI3K activity with 10 muM LY294002 decreased estrogen-stimulated hSlo1 transcription by ~40%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	92-97
21128229-7	2011	The data demonstrated that Akt activity inhibitor LY294002 synergistically promoted tetrandrine-induced apoptosis of HCC, whereas ectopic expression of Akt contrastly abrogated partial of the tetrandrine-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	27-30
22025881-8	2011	Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	74-103
22082269-4	2011	This effect was found to depend on Akt kinase activity: the Akt activity inhibitor Ly 294002 increased the amount of MRP1 mRNA in KB 8-5 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-92	AKT serine/threonine kinase 1	Homo sapiens	35-38
21765100-7	2011	Pretreatment with phosphatidylinositide 3-kinase/Akt inhibitor (LY-294002) prior to Ucn2 led to downregulation of CREB phosphorylation and hence reduced Bcl-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	AKT serine/threonine kinase 1	Homo sapiens	49-52
21765100-7	2011	Pretreatment with phosphatidylinositide 3-kinase/Akt inhibitor (LY-294002) prior to Ucn2 led to downregulation of CREB phosphorylation and hence reduced Bcl-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	cAMP responsive element binding protein 1	Homo sapiens	114-118
21765100-7	2011	Pretreatment with phosphatidylinositide 3-kinase/Akt inhibitor (LY-294002) prior to Ucn2 led to downregulation of CREB phosphorylation and hence reduced Bcl-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	BCL2 apoptosis regulator	Homo sapiens	153-158
21693693-5	2011	Insulin-mediated decrease in menin expression was abrogated by the PI3K/Akt inhibitor LY-294002 at early time points, from 2 to 7 h. Furthermore, exposure to insulin resulted in the cytoplasmic localization of menin and increased interaction with FOXO1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-95	insulin	Homo sapiens	0-7
21693693-5	2011	Insulin-mediated decrease in menin expression was abrogated by the PI3K/Akt inhibitor LY-294002 at early time points, from 2 to 7 h. Furthermore, exposure to insulin resulted in the cytoplasmic localization of menin and increased interaction with FOXO1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-95	menin 1	Homo sapiens	29-34
21693693-5	2011	Insulin-mediated decrease in menin expression was abrogated by the PI3K/Akt inhibitor LY-294002 at early time points, from 2 to 7 h. Furthermore, exposure to insulin resulted in the cytoplasmic localization of menin and increased interaction with FOXO1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-95	AKT serine/threonine kinase 1	Homo sapiens	72-75
21693693-5	2011	Insulin-mediated decrease in menin expression was abrogated by the PI3K/Akt inhibitor LY-294002 at early time points, from 2 to 7 h. Furthermore, exposure to insulin resulted in the cytoplasmic localization of menin and increased interaction with FOXO1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-95	insulin	Homo sapiens	158-165
21693693-5	2011	Insulin-mediated decrease in menin expression was abrogated by the PI3K/Akt inhibitor LY-294002 at early time points, from 2 to 7 h. Furthermore, exposure to insulin resulted in the cytoplasmic localization of menin and increased interaction with FOXO1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-95	menin 1	Homo sapiens	210-215
21693693-5	2011	Insulin-mediated decrease in menin expression was abrogated by the PI3K/Akt inhibitor LY-294002 at early time points, from 2 to 7 h. Furthermore, exposure to insulin resulted in the cytoplasmic localization of menin and increased interaction with FOXO1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-95	forkhead box O1	Homo sapiens	247-252
22082269-4	2011	This effect was found to depend on Akt kinase activity: the Akt activity inhibitor Ly 294002 increased the amount of MRP1 mRNA in KB 8-5 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-92	AKT serine/threonine kinase 1	Homo sapiens	60-63
22082269-4	2011	This effect was found to depend on Akt kinase activity: the Akt activity inhibitor Ly 294002 increased the amount of MRP1 mRNA in KB 8-5 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-92	ATP binding cassette subfamily C member 1	Homo sapiens	117-121
21620964-6	2011	In addition, PI3K/Akt inhibitor (LY294002) blocked Bay-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Homo sapiens	18-21
21449895-7	2011	When the PI3K-Akt pathway was inhibited by LY294002, the adhesion and migration of BM-MSCs from ICR mice were suppressed as well.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	thymoma viral proto-oncogene 1	Mus musculus	14-17
21620964-6	2011	In addition, PI3K/Akt inhibitor (LY294002) blocked Bay-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	heme oxygenase 1	Homo sapiens	63-67
21513816-6	2011	Treatment with PI3K inhibitors, wortmannin and LY294002, inhibited LTA-induced phosphorylation of AKT and GSK-3, demonstrating that these events require PI3K activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	98-101
21617882-8	2011	Furthermore, transduction with constitutively active Akt protected against the quercetin-induced dephosphorylation of Akt and Bad as well as poly(ADP-ribose)polymerase (PARP) degradation, while combined treatment with quercetin and LY294002 enhanced the dephosphorylation of Akt, Bad and PARP cleavage in U2-OS/MTX300 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	232-240	AKT serine/threonine kinase 1	Homo sapiens	53-56
21544859-5	2011	And pretreatment of cells with either PI3-kinase inhibitor (LY294002) or cholesterol depleting agent (methyl-beta-cyclodextrin, MbetaCD) abolished the inhibitory activity of thrombin against sPLA(2)-IIA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	peptidase inhibitor 3	Homo sapiens	38-41
21544859-5	2011	And pretreatment of cells with either PI3-kinase inhibitor (LY294002) or cholesterol depleting agent (methyl-beta-cyclodextrin, MbetaCD) abolished the inhibitory activity of thrombin against sPLA(2)-IIA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	coagulation factor II, thrombin	Homo sapiens	174-182
21671255-9	2011	LY294002 (30 muM), a PI3K inhibitor, attenuated guanosine-induced neuroprotection, guanosine prevention of glutamate release, and guanosine-induced GSK3beta(Ser9) phosphorylation but not guanosine reduction of glutamate-induced iNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	148-156
21671255-9	2011	LY294002 (30 muM), a PI3K inhibitor, attenuated guanosine-induced neuroprotection, guanosine prevention of glutamate release, and guanosine-induced GSK3beta(Ser9) phosphorylation but not guanosine reduction of glutamate-induced iNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 2	Rattus norvegicus	228-232
21567071-6	2011	The effect of IGF-1 was abolished by pre-treatment for 1 h with 30 microM LY294002 (a specific PI3-K inhibitor), and significantly inhibited by 30 microM SB202190 (a specific p38MAPK inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	insulin like growth factor 1	Homo sapiens	14-19
21712253-5	2011	Treatment of MCF/HER2 cells with the PI3K inhibitor LY294002, the IkappaB phosphorylation inhibitor Bay11-7082, and the dominant negative mutant of IkappaBalpha inhibited HER2-induced BCRP promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-21
21336564-4	2011	Rapamycin potentiated differentiation of ATRA-treated NB4 cells, but the combination of rapamycin and LY 294002 inhibited the expression of CD11b in both ATRA- and phorbol myristate acetate (PMA)-stimulated cells more than PI3K inhibitor alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-111	integrin subunit alpha M	Homo sapiens	140-145
21336564-5	2011	These results demonstrate that, although the combination of PI3K inhibitor and rapamycin is more effective in inhibiting proliferation of AML, the concomitant inhibition of PI3K and mTOR by LY 294002 and rapamycin has more inhibitory effects on ATRA-mediated differentiation than the presence of PI3K-inhibitor alone, and diminishes positive effects of rapamycin on leukemia cell differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-199	mechanistic target of rapamycin kinase	Homo sapiens	182-186
21821001-3	2011	Galectin-3 expression was time- and transcription-dependently deregulated in K562 chronic myeloid leukemia cells stimulated for apoptosis by cisplatin (a platinum-based chemotherapy drug), sphingolipid ceramide analog C(2)-ceramide, and LY294002 (a phosphatidylinositol 3-kinase inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	237-245	galectin 3	Homo sapiens	0-10
21864408-8	2011	We used the inhibitors LY294002, Akti-1/2, and rapamycin, to show that p21 induction is dependent upon PI3-kinase and AKT activity, and partially dependent on mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	H3 histone pseudogene 16	Homo sapiens	71-74
21864408-12	2011	We found that a combined treatment of LY294002 and SB-216763 improved the cytotoxic effect against UMUC-3 and UMUC-14 carcinoma cells over LY294002 alone, suggesting potential therapeutic uses for GSK-3beta inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	glycogen synthase kinase 3 beta	Homo sapiens	197-206
21802413-6	2011	Under inhibition of PI3 kinase by LY294002, the suppressive effect of miR-491 on HCV replication was abolished, indicating that suppression of HCV replication by miR-491 was dependent on the PI3 kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	microRNA 491	Homo sapiens	70-77
21802413-6	2011	Under inhibition of PI3 kinase by LY294002, the suppressive effect of miR-491 on HCV replication was abolished, indicating that suppression of HCV replication by miR-491 was dependent on the PI3 kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	microRNA 491	Homo sapiens	162-169
21802413-6	2011	Under inhibition of PI3 kinase by LY294002, the suppressive effect of miR-491 on HCV replication was abolished, indicating that suppression of HCV replication by miR-491 was dependent on the PI3 kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	202-205
24843496-10	2011	VEGF significantly increased the proliferation and suppressed the apoptosis of EPC, both of which were abolished by PI 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	vascular endothelial growth factor A	Homo sapiens	0-4
21861059-11	2011	However, compared with the high glucose + GLP-1 group, LY294002, an inhibitor of PI3K-Akt signal path, attenuated the protective effect of GLP-1 in the high glucose + GLP-1 + LY294002 group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Rattus norvegicus	86-89
21861059-11	2011	However, compared with the high glucose + GLP-1 group, LY294002, an inhibitor of PI3K-Akt signal path, attenuated the protective effect of GLP-1 in the high glucose + GLP-1 + LY294002 group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	glucagon	Rattus norvegicus	139-144
21861059-11	2011	However, compared with the high glucose + GLP-1 group, LY294002, an inhibitor of PI3K-Akt signal path, attenuated the protective effect of GLP-1 in the high glucose + GLP-1 + LY294002 group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	glucagon	Rattus norvegicus	139-144
21861059-11	2011	However, compared with the high glucose + GLP-1 group, LY294002, an inhibitor of PI3K-Akt signal path, attenuated the protective effect of GLP-1 in the high glucose + GLP-1 + LY294002 group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	glucagon	Rattus norvegicus	139-144
21861059-11	2011	However, compared with the high glucose + GLP-1 group, LY294002, an inhibitor of PI3K-Akt signal path, attenuated the protective effect of GLP-1 in the high glucose + GLP-1 + LY294002 group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	glucagon	Rattus norvegicus	139-144
21838918-10	2011	Furthermore, we found that the Akt inhibitor LY294002 restored SPC-mediated downregulation of LC3 II and inhibited the activation of mTOR by SPC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	thymoma viral proto-oncogene 1	Mus musculus	31-34
21838918-10	2011	Furthermore, we found that the Akt inhibitor LY294002 restored SPC-mediated downregulation of LC3 II and inhibited the activation of mTOR by SPC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	mechanistic target of rapamycin kinase	Mus musculus	133-137
21712253-5	2011	Treatment of MCF/HER2 cells with the PI3K inhibitor LY294002, the IkappaB phosphorylation inhibitor Bay11-7082, and the dominant negative mutant of IkappaBalpha inhibited HER2-induced BCRP promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	erb-b2 receptor tyrosine kinase 2	Homo sapiens	171-175
21518140-5	2011	GM3 signals regulating Ly-GDI expression was inhibited by LY294002, siRNA against Akt1 and Akt2 and rapamycin, showing that GM3 signals are transduced via the PI3K/Akt/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	Rho GDP dissociation inhibitor beta	Homo sapiens	23-29
20972874-1	2011	PURPOSE: Studies of SF1126, an RGDS targeted, water-soluble prodrug of LY294002, are currently nearing completion in two adult Phase I trials.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	ral guanine nucleotide dissociation stimulator	Homo sapiens	31-35
21765447-8	2011	AA inhibited Akt activation, which was attenuated by pretreatment of the cells with LY294002 (20 mumol/L) or wortmannin (50 nmol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Homo sapiens	13-16
21480865-8	2011	ACEA, JWH133 and HU210 induced a time-dependent phosphorylation of Akt and mTOR, whereas the inhibitors of PI3K/Akt (LY294002) or of mTOR (rapamycin) reversed the effects of HU-210 on oligodendrocyte differentiation and kinase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	67-70
21518140-5	2011	GM3 signals regulating Ly-GDI expression was inhibited by LY294002, siRNA against Akt1 and Akt2 and rapamycin, showing that GM3 signals are transduced via the PI3K/Akt/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	Megator	Drosophila melanogaster	168-172
21561530-8	2011	In a mouse tumor model, we found the phosphorylation of Akt obviously increased following anti-angiogenic therapy using plasmids encoding soluble vascular endothelial growth factor receptor-2, but significantly reduced after treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	240-248	thymoma viral proto-oncogene 1	Mus musculus	56-59
21616556-7	2011	Moreover, the avbeta3 antibody, the PI3-K inhibitor LY294002 and the eNOS inhibitor NMA suppressed the OPN-mediated increase in NO production and angiogenesis in EPCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	secreted phosphoprotein 1	Homo sapiens	103-106
21693679-9	2011	Inhibition of the Akt signaling pathway by the phosphatidylinositol 3 kinase inhibitor LY294002 counteracted the antiapoptotic effect of ApoCIII on cytokine-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
21693679-9	2011	Inhibition of the Akt signaling pathway by the phosphatidylinositol 3 kinase inhibitor LY294002 counteracted the antiapoptotic effect of ApoCIII on cytokine-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	apolipoprotein C3	Rattus norvegicus	137-144
21573502-4	2011	HeLa in the absence of Ku80 and pretreated with LY294002, a chemically specific PI 3-kinase inhibitor, resulted in cells that were even more sensitive to X-rays than HeLa/Ku80-siRNA transfected with DNA- PKcs-siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	X-ray repair cross complementing 5	Homo sapiens	171-175
21569124-4	2011	Our data show that cytochalasin B, LY294002, wortmannin, nocodazole, MG132 and XVA143 inhibitors reduced LVS uptake by &gt;50% in these assays without having significant cytotoxic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	lacking vigorous sperm	Mus musculus	105-108
21550417-11	2011	LY294002 that suppressed phosphorylated Akt but not phosphorylated focal adhesion kinase inhibited cell proliferation but had no effect on cell adhesion or migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	40-43
21352962-6	2011	alphavbeta5 monoclonal antibody (mAb), phosphatidylinositol 3-kinase inhibitor (PI3K; Ly294002 and wortmannin) and Akt inhibitor reversed the CTGF-inhibited the migration and COX-2 down-regulation of oral cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	39-78
21352962-6	2011	alphavbeta5 monoclonal antibody (mAb), phosphatidylinositol 3-kinase inhibitor (PI3K; Ly294002 and wortmannin) and Akt inhibitor reversed the CTGF-inhibited the migration and COX-2 down-regulation of oral cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	cellular communication network factor 2	Homo sapiens	142-146
21303966-12	2011	In the presence of the PI-3 kinase inhibitor LY294002, the ability of CRP to suppress caspase-3 activity was significantly reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	C-reactive protein	Homo sapiens	70-73
21616916-3	2011	Our data here show that hyperactive AKT leads to the decrease of IGF1R at the transcriptional level, which could be partly restored by phosphatidylinositol-3 kinase (PI3K) inhibitors including wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	AKT serine/threonine kinase 1	Homo sapiens	36-39
21616916-3	2011	Our data here show that hyperactive AKT leads to the decrease of IGF1R at the transcriptional level, which could be partly restored by phosphatidylinositol-3 kinase (PI3K) inhibitors including wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	insulin like growth factor 1 receptor	Homo sapiens	65-70
21730021-7	2011	The PI3K-Akt inhibitor, LY294002, completely blocked adipocyte differentiation of MSCs, unveiling that the reduced adipogenic potential of Ncam(-/-) MSCs is due to insulin resistance as a result of loss of NCAM function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	thymoma viral proto-oncogene 1	Mus musculus	9-12
21730021-7	2011	The PI3K-Akt inhibitor, LY294002, completely blocked adipocyte differentiation of MSCs, unveiling that the reduced adipogenic potential of Ncam(-/-) MSCs is due to insulin resistance as a result of loss of NCAM function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	neural cell adhesion molecule 1	Mus musculus	139-143
21730021-7	2011	The PI3K-Akt inhibitor, LY294002, completely blocked adipocyte differentiation of MSCs, unveiling that the reduced adipogenic potential of Ncam(-/-) MSCs is due to insulin resistance as a result of loss of NCAM function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	neural cell adhesion molecule 1	Mus musculus	206-210
21520056-5	2011	The addition of serum might block the Abeta(25-35)-induced cytotoxic effect via elevated telomerase activity in according with stimulating phospho-AKT protein expression, which was blocked by adding AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	AKT serine/threonine kinase 1	Homo sapiens	147-150
21520056-5	2011	The addition of serum might block the Abeta(25-35)-induced cytotoxic effect via elevated telomerase activity in according with stimulating phospho-AKT protein expression, which was blocked by adding AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	AKT serine/threonine kinase 1	Homo sapiens	199-202
21303966-12	2011	In the presence of the PI-3 kinase inhibitor LY294002, the ability of CRP to suppress caspase-3 activity was significantly reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	caspase 3	Homo sapiens	86-95
21471274-8	2011	Visfatin also activated the ERK1/2 and the phosphoinositide 3-kinase (PI3K)/AKT signaling pathways in a time- and concentration-dependent manner, and the effect of visfatin on apoptosis was blocked by the specific ERK1/2 and PI3K/AKT inhibitors, PD098059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	259-267	nicotinamide phosphoribosyltransferase	Mus musculus	0-8
21683105-2	2011	Here we show that inhibition of PI3K/Akt by means of LY294002 induces apoptosis via a caspase-dependent and calpain-independent pathway in cerebellar granule neurons (CGNs).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	37-40
21683105-11	2011	Although previous reports suggest that apoptosis induced in CGNs by LY294002 and S/K deprivation causes PI3K inhibition and increases GSK3beta activity and c-Jun phosphorylation activation, our results demonstrate substantial differences between them and point to a key role of GSK3beta in the apoptosis induced in CGNs in the two models tested.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	glycogen synthase kinase 3 beta	Homo sapiens	134-142
21683105-11	2011	Although previous reports suggest that apoptosis induced in CGNs by LY294002 and S/K deprivation causes PI3K inhibition and increases GSK3beta activity and c-Jun phosphorylation activation, our results demonstrate substantial differences between them and point to a key role of GSK3beta in the apoptosis induced in CGNs in the two models tested.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	156-161
21683105-11	2011	Although previous reports suggest that apoptosis induced in CGNs by LY294002 and S/K deprivation causes PI3K inhibition and increases GSK3beta activity and c-Jun phosphorylation activation, our results demonstrate substantial differences between them and point to a key role of GSK3beta in the apoptosis induced in CGNs in the two models tested.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	glycogen synthase kinase 3 beta	Homo sapiens	278-286
21429662-7	2011	Although LY294002 alone did not affect the cell viability, it suppressed the Akt and S6K activities and induced the sub-G1 arrest/apoptosis when paclitaxel was co-administered, as well as the Akt siRNA and rapamycin did.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	77-80
21406596-9	2011	The PI3K/Akt signalling pathway activation by hemin was related to heme oxygenase-1 activation and an increase in biliverdin reductase, and its inhibition by LY294002 reversed the effects of hemin on collagen I and caspase-3 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	AKT serine/threonine kinase 1	Rattus norvegicus	9-12
21471274-8	2011	Visfatin also activated the ERK1/2 and the phosphoinositide 3-kinase (PI3K)/AKT signaling pathways in a time- and concentration-dependent manner, and the effect of visfatin on apoptosis was blocked by the specific ERK1/2 and PI3K/AKT inhibitors, PD098059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	259-267	nicotinamide phosphoribosyltransferase	Mus musculus	164-172
21389278-8	2011	Furthermore, the PTH-stimulated HCO3-secretion was markedly reduced by protein kinase A (PKA) inhibitor (PKI 14-22 amide) and phosphoinositide 3-kinase (PI3K) inhibitors (wortmannin and LY-294002), but not by intracellular Ca2+ chelator (BAPTA-AM) or protein kinase C inhibitor (GF-109203X).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-195	parathyroid hormone	Homo sapiens	17-20
21511697-5	2011	Conversely, the phosphoinositide 3-kinase (PI3K) inhibitor LY 294002 diminished phosphorylation of Akt (S473) and AS160.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	thymoma viral proto-oncogene 1	Mus musculus	99-102
21511697-5	2011	Conversely, the phosphoinositide 3-kinase (PI3K) inhibitor LY 294002 diminished phosphorylation of Akt (S473) and AS160.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	TBC1 domain family, member 4	Mus musculus	114-119
21490369-7	2011	GH stimulated hepatic expression of IGF-1 mRNA as well as the secretion of IGF-1, effects that were partially or completely blocked by U0126, LY294002, and Hex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	insulin-like growth factor I	Oncorhynchus mykiss	36-41
21490369-7	2011	GH stimulated hepatic expression of IGF-1 mRNA as well as the secretion of IGF-1, effects that were partially or completely blocked by U0126, LY294002, and Hex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	insulin-like growth factor I	Oncorhynchus mykiss	75-80
21536288-7	2011	The mitogenic effect of MCP-3 appeared to be dependent on ERK1/2 MAPK and PI3K signaling pathway activation, as demonstrated by the reduction of MCP-3-induced CASMC proliferation observed after the treatment of cells with U0126 (1 muM) and LY-294002 (5muM), selective inhibitors of ERK 1/2 and PI3K activation, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	240-249	C-C motif chemokine ligand 7	Homo sapiens	24-29
21536288-7	2011	The mitogenic effect of MCP-3 appeared to be dependent on ERK1/2 MAPK and PI3K signaling pathway activation, as demonstrated by the reduction of MCP-3-induced CASMC proliferation observed after the treatment of cells with U0126 (1 muM) and LY-294002 (5muM), selective inhibitors of ERK 1/2 and PI3K activation, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	240-249	C-C motif chemokine ligand 7	Homo sapiens	145-150
21477582-7	2011	The induction of UBE2M and reduction of p27(Kip1) by Gem were prevented by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	ubiquitin conjugating enzyme E2 M	Homo sapiens	17-22
21477582-7	2011	The induction of UBE2M and reduction of p27(Kip1) by Gem were prevented by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	interferon alpha inducible protein 27	Homo sapiens	40-43
21477582-7	2011	The induction of UBE2M and reduction of p27(Kip1) by Gem were prevented by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	cyclin dependent kinase inhibitor 1B	Homo sapiens	44-48
21050358-10	2011	LY294002, a pharmacological inhibitor of phosphatidylinositol 3-kinase (PI3K), significantly inhibited PC-3 and DU-145 cell proliferation after resistin treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	chromobox 8	Homo sapiens	103-107
21050358-10	2011	LY294002, a pharmacological inhibitor of phosphatidylinositol 3-kinase (PI3K), significantly inhibited PC-3 and DU-145 cell proliferation after resistin treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	resistin	Homo sapiens	144-152
21536288-7	2011	The mitogenic effect of MCP-3 appeared to be dependent on ERK1/2 MAPK and PI3K signaling pathway activation, as demonstrated by the reduction of MCP-3-induced CASMC proliferation observed after the treatment of cells with U0126 (1 muM) and LY-294002 (5muM), selective inhibitors of ERK 1/2 and PI3K activation, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	240-249	mitogen-activated protein kinase 3	Homo sapiens	58-64
21530509-9	2011	The effect of ghrelin on motoneuron survival was blocked by the MEK inhibitor PD98059 and the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	94-123
23554696-5	2011	Blocking PI3K/Akt signalling with LY294002 or Akt siRNA remarkably inhibited both EGF-induced PAK1 activation and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	14-17
23554696-5	2011	Blocking PI3K/Akt signalling with LY294002 or Akt siRNA remarkably inhibited both EGF-induced PAK1 activation and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	epidermal growth factor	Homo sapiens	82-85
23554696-5	2011	Blocking PI3K/Akt signalling with LY294002 or Akt siRNA remarkably inhibited both EGF-induced PAK1 activation and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	p21 (RAC1) activated kinase 1	Homo sapiens	94-98
21561856-6	2011	In addition, similar to the effect of the PI3K inhibitor LY294002, caffeine also inhibited phosphorylation of AKT and up-regulation of COX-2, two critical oncogenic pathways in skin tumorigenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
21666495-5	2011	Administration of the tyrosine kinase receptor B inhibitor K-252a, the mitogen-activated protein kinase 1 inhibitor PD98059, and the phosphatidylinositol-3-OH kinase inhibitor LY294002 abolished BDNF-induced upregulation of these transcription factors and telomerase expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	brain-derived neurotrophic factor	Rattus norvegicus	195-199
21338617-6	2011	Inhibition of phosphatidylinositol 3-kinase or Akt with LY 294002 or Akti-1/2 stimulates HSP27 phosphorylation while rapamycin, which inhibits mTORC1, does not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-65	AKT serine/threonine kinase 1	Homo sapiens	47-50
21545837-9	2011	Clues as to the mechanism for this protective effect come from (a) increased AKT phosphorylation observed in IGF-1-protected cells, vs. cells exposed to Epoxomicin without IGF-1, and (b) reduction of IGF-1 protection by pretreatment of the cells with LY294002 (an inhibitor of PI3-kinase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	insulin like growth factor 1	Homo sapiens	109-114
21351249-9	2011	Treatment with the PI3K inhibitor LY294002 mimicked LA actions, dramatically inhibiting both leptin secretion and gene expression and stimulating Sp1 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	leptin	Rattus norvegicus	93-99
21338617-6	2011	Inhibition of phosphatidylinositol 3-kinase or Akt with LY 294002 or Akti-1/2 stimulates HSP27 phosphorylation while rapamycin, which inhibits mTORC1, does not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-65	heat shock protein family B (small) member 1	Homo sapiens	89-94
21501655-5	2011	Insulin suppressed Angptl2 mRNA expression in dose-dependent manners, which could be attenuated by a phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	insulin	Homo sapiens	0-7
21501655-5	2011	Insulin suppressed Angptl2 mRNA expression in dose-dependent manners, which could be attenuated by a phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	angiopoietin like 2	Homo sapiens	19-26
21501655-5	2011	Insulin suppressed Angptl2 mRNA expression in dose-dependent manners, which could be attenuated by a phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	101-126
21357506-6	2011	We showed that LY-294002, a PI3K inhibitor, suppressed HIF-1alpha and VEGF induction under hypoxic conditions by up to 50%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65
21308383-5	2011	The effects of SPRC were abolished by cystathionine gamma-lyase [CSE-an enzyme that synthesizes hydrogen sulfide (H(2)S)] inhibitor, DL: -propargylglycine (PAG), SPRC-induced Akt phosphorylation and TNF-alpha release was also abolished by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	286-294	cystathionine gamma-lyase	Rattus norvegicus	38-63
21357506-6	2011	We showed that LY-294002, a PI3K inhibitor, suppressed HIF-1alpha and VEGF induction under hypoxic conditions by up to 50%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	vascular endothelial growth factor A	Homo sapiens	70-74
21073857-4	2011	Rapamycin and LY-294002, an inhibitor of phosphatidilinositol-3 kinase (PI3K) located upstream of mTOR, inhibited epidermal growth factor (EGF)-induced expression of the TRPM6 protein without affecting TRPM7 expression in rat renal NRK-52E epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-23	mechanistic target of rapamycin kinase	Rattus norvegicus	98-102
21073857-8	2011	EGF increased p-Akt level, an effect inhibited by LY-294002 and 1L-6-hydroxymethyl-chiro-inositol2-[(R)-2-O-methyl-3-O-octadecylcarbonate] (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	epidermal growth factor	Homo sapiens	0-3
21073857-8	2011	EGF increased p-Akt level, an effect inhibited by LY-294002 and 1L-6-hydroxymethyl-chiro-inositol2-[(R)-2-O-methyl-3-O-octadecylcarbonate] (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	AKT serine/threonine kinase 1	Homo sapiens	16-19
21073857-4	2011	Rapamycin and LY-294002, an inhibitor of phosphatidilinositol-3 kinase (PI3K) located upstream of mTOR, inhibited epidermal growth factor (EGF)-induced expression of the TRPM6 protein without affecting TRPM7 expression in rat renal NRK-52E epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-23	epidermal growth factor like 1	Rattus norvegicus	114-137
21073857-4	2011	Rapamycin and LY-294002, an inhibitor of phosphatidilinositol-3 kinase (PI3K) located upstream of mTOR, inhibited epidermal growth factor (EGF)-induced expression of the TRPM6 protein without affecting TRPM7 expression in rat renal NRK-52E epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-23	epidermal growth factor like 1	Rattus norvegicus	139-142
21073857-4	2011	Rapamycin and LY-294002, an inhibitor of phosphatidilinositol-3 kinase (PI3K) located upstream of mTOR, inhibited epidermal growth factor (EGF)-induced expression of the TRPM6 protein without affecting TRPM7 expression in rat renal NRK-52E epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-23	transient receptor potential cation channel, subfamily M, member 6	Rattus norvegicus	170-175
21073857-4	2011	Rapamycin and LY-294002, an inhibitor of phosphatidilinositol-3 kinase (PI3K) located upstream of mTOR, inhibited epidermal growth factor (EGF)-induced expression of the TRPM6 protein without affecting TRPM7 expression in rat renal NRK-52E epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-23	transient receptor potential cation channel, subfamily M, member 7	Rattus norvegicus	202-207
21514778-16	2011	Preincubation with CXCR4-Ab, AMD3100, or LY294002 significantly attenuated the enhanced in vitro and in vivo effects of Foxc2-EPCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	forkhead box C2	Mus musculus	120-125
21673451-6	2011	Inhibition studies using LY294002 revealed the requirement of PI3K/Akt pathway for NO production and NF-kappaB activation by HBFN-f. Anti-CD44 treatment with anti-CD44 antibody and hyaluronan resulted in significant inhibition of HBFN-f actions on NO, NF-kappaB, and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	CD44 molecule (Indian blood group)	Homo sapiens	138-142
21684102-6	2011	Furthermore, the TIMP-1-induced attenuation of the effect of epirubicin and paclitaxel was reversed by the PI3K/Akt chemical inhibitor LY294002 and the NF-kB inhibitor pyrrolidine dithiocarbamate (PDTC), showing that the PI3K/Akt and NF-kB signaling pathway was involved in the TIMP-1-induced effect on chemoresistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	TIMP metallopeptidase inhibitor 1	Homo sapiens	17-23
21684102-6	2011	Furthermore, the TIMP-1-induced attenuation of the effect of epirubicin and paclitaxel was reversed by the PI3K/Akt chemical inhibitor LY294002 and the NF-kB inhibitor pyrrolidine dithiocarbamate (PDTC), showing that the PI3K/Akt and NF-kB signaling pathway was involved in the TIMP-1-induced effect on chemoresistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Homo sapiens	112-115
21538027-7	2011	The effects of the PI3K inhibitor LY294002 on TRAIL-induced apoptosis were similar to those of NVP-AEW541, further supporting a role for IGF-1R-mediated activation of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	TNF superfamily member 10	Homo sapiens	46-51
21296696-6	2011	Moreover, cotreatment of ICI182780 or LY294002 inhibited costunolide-mediated upregulation of mineralization, suggesting that the induction of mineralization by costunolide is associated with increased activation of ER and PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	estrogen receptor 1 (alpha)	Mus musculus	216-218
24048786-10	2011	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and a dominant-negative protein kinase C (AKT) construct prevented the induction of MUC5AC by conjugated bile acids.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-33
24048786-10	2011	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and a dominant-negative protein kinase C (AKT) construct prevented the induction of MUC5AC by conjugated bile acids.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	144-150
21513489-5	2011	This effect can be inhibited by the PI3K/Akt inhibitor Ly294002, indicating the important role of this pathway in the insulin-induced inefficacy of chemotherapy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	41-44
21513489-5	2011	This effect can be inhibited by the PI3K/Akt inhibitor Ly294002, indicating the important role of this pathway in the insulin-induced inefficacy of chemotherapy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	insulin	Homo sapiens	118-125
21590646-8	2011	After LY294002 administration in non-TN-treated cells, cell viability was reduced, and CHOP and Bax protein levels were elevated, and Bcl-2 protein levels were reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	DNA-damage inducible transcript 3	Rattus norvegicus	87-91
21590646-8	2011	After LY294002 administration in non-TN-treated cells, cell viability was reduced, and CHOP and Bax protein levels were elevated, and Bcl-2 protein levels were reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	BCL2 associated X, apoptosis regulator	Rattus norvegicus	96-99
21590646-8	2011	After LY294002 administration in non-TN-treated cells, cell viability was reduced, and CHOP and Bax protein levels were elevated, and Bcl-2 protein levels were reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	BCL2, apoptosis regulator	Rattus norvegicus	134-139
21590646-10	2011	LY294002 and wortmannin decreased cell viability, and increased CHOP and Bax protein levels, and decreased Bcl-2 protein levels in ALA-pretreated and TN-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	DNA-damage inducible transcript 3	Rattus norvegicus	64-68
21590646-10	2011	LY294002 and wortmannin decreased cell viability, and increased CHOP and Bax protein levels, and decreased Bcl-2 protein levels in ALA-pretreated and TN-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	73-76
21590646-10	2011	LY294002 and wortmannin decreased cell viability, and increased CHOP and Bax protein levels, and decreased Bcl-2 protein levels in ALA-pretreated and TN-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2, apoptosis regulator	Rattus norvegicus	107-112
21318349-5	2011	Five minutes treatment with leptin (3.1 nM) resulted in activation of RhoA and Rac1 (by 330 and 160%, respectively, P &lt; 0.05) which was significantly attenuated by AG-490 (50 muM) and LY294002 (10 muM), specific inhibitors of JAK2 and PI3K, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	Rac family small GTPase 1	Homo sapiens	79-83
21318349-5	2011	Five minutes treatment with leptin (3.1 nM) resulted in activation of RhoA and Rac1 (by 330 and 160%, respectively, P &lt; 0.05) which was significantly attenuated by AG-490 (50 muM) and LY294002 (10 muM), specific inhibitors of JAK2 and PI3K, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	latexin	Homo sapiens	178-181
21318349-5	2011	Five minutes treatment with leptin (3.1 nM) resulted in activation of RhoA and Rac1 (by 330 and 160%, respectively, P &lt; 0.05) which was significantly attenuated by AG-490 (50 muM) and LY294002 (10 muM), specific inhibitors of JAK2 and PI3K, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	latexin	Homo sapiens	200-203
21318349-5	2011	Five minutes treatment with leptin (3.1 nM) resulted in activation of RhoA and Rac1 (by 330 and 160%, respectively, P &lt; 0.05) which was significantly attenuated by AG-490 (50 muM) and LY294002 (10 muM), specific inhibitors of JAK2 and PI3K, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	Janus kinase 2	Homo sapiens	229-233
20848249-7	2011	Then pretreatment of Panc-1 cells with LY294002, an inhibitor of the PI3K/AKT pathway, significantly inhibited BMP-2-induced EMT and invasiveness.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	74-77
21468550-11	2011	Furthermore, the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	microRNA 21	Homo sapiens	17-23
21468550-11	2011	Furthermore, the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	BCL2 apoptosis regulator	Homo sapiens	32-37
20848249-7	2011	Then pretreatment of Panc-1 cells with LY294002, an inhibitor of the PI3K/AKT pathway, significantly inhibited BMP-2-induced EMT and invasiveness.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	bone morphogenetic protein 2	Homo sapiens	111-116
21438539-5	2011	Nrf2 expression was attenuated by LY294002 and U0126, inhibitors of phosphatidylinositol-3-kinase and MEK1/2, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
21823424-13	2011	The effects of electroacupuncture reversed the abnormally increased NO levels of the hippocampus and the cerebral cortex and expressions of nNOS and iNOS after LY294002 oppressed anti-PI3K to block the TrkA acceptor circuit.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	nitric oxide synthase 1	Rattus norvegicus	140-144
21823424-13	2011	The effects of electroacupuncture reversed the abnormally increased NO levels of the hippocampus and the cerebral cortex and expressions of nNOS and iNOS after LY294002 oppressed anti-PI3K to block the TrkA acceptor circuit.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	nitric oxide synthase 2	Rattus norvegicus	149-153
21823424-13	2011	The effects of electroacupuncture reversed the abnormally increased NO levels of the hippocampus and the cerebral cortex and expressions of nNOS and iNOS after LY294002 oppressed anti-PI3K to block the TrkA acceptor circuit.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	202-206
21406184-6	2011	In addition, FTI-induced Akt activation was attenuated by the PI3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Rattus norvegicus	25-28
21349267-8	2011	Co-administration with the delta-opioid receptor antagonist naltrindole or pretreatment with the Akt antagonist LY294002 completely abolished the DADLE postconditioning effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
21438539-5	2011	Nrf2 expression was attenuated by LY294002 and U0126, inhibitors of phosphatidylinositol-3-kinase and MEK1/2, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	mitogen-activated protein kinase kinase 1	Homo sapiens	102-108
21273548-5	2011	beta3 Integrin signaling involvement was determined using a PI3-kinase (LY294002) or Rac1 (NSC23766) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	0-5
21454688-4	2011	Treatment with a potent PI3K inhibitor (LY294002) blocked the prosurvival and promotility effects of TGFbeta, indicating that TGFbeta-mediated promotion of cell survival and motility is dependent upon activation of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	transforming growth factor beta 1	Homo sapiens	101-108
21454688-4	2011	Treatment with a potent PI3K inhibitor (LY294002) blocked the prosurvival and promotility effects of TGFbeta, indicating that TGFbeta-mediated promotion of cell survival and motility is dependent upon activation of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	transforming growth factor beta 1	Homo sapiens	126-133
21454688-4	2011	Treatment with a potent PI3K inhibitor (LY294002) blocked the prosurvival and promotility effects of TGFbeta, indicating that TGFbeta-mediated promotion of cell survival and motility is dependent upon activation of the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	224-227
21276823-10	2011	We demonstrate that CsA and LY294002 reduced MMP transcription partly via modulation of IkappaB phosphorylation and NFkappaB transcriptional activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	matrix metallopeptidase 2	Homo sapiens	45-48
21257786-12	2011	LY294002 reduced COPD neutrophil migratory speed while increasing chemotactic accuracy, returning values to normal.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	COPD	Homo sapiens	17-21
21282571-6	2011	The contribution of non-Smad signaling pathways to TGF-beta-induced alpha-SMA and PAI-1 expression was assessed using the small molecule inhibitors U0126 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	transforming growth factor beta 1	Homo sapiens	51-59
21276823-10	2011	We demonstrate that CsA and LY294002 reduced MMP transcription partly via modulation of IkappaB phosphorylation and NFkappaB transcriptional activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	nuclear factor kappa B subunit 1	Homo sapiens	116-124
21538894-5	2011	Furthermore, phosphorylation of Akt and antioxidant response element-mediated reporter gene expression were enhanced by glyceollins but suppressed by LY294002, an inhibitor of phosphoinositide 3-kinases (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	thymoma viral proto-oncogene 1	Mus musculus	32-35
21447487-9	2011	Subsequent activation of MMPs resulted in increased cell migration, invasion, and wound-healing activity under hypoxia-reoxygenation, which was decreased by LY294002 (AKT inhibitor) and U0126 (ERK inhibitor) in rat cardiac fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	matrix metallopeptidase 2	Rattus norvegicus	25-29
21255641-3	2011	LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, inhibited Akt activation and induced apoptotic cell death in cells expressing JAK2 V617F mutant and EpoR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	12-37
21447487-9	2011	Subsequent activation of MMPs resulted in increased cell migration, invasion, and wound-healing activity under hypoxia-reoxygenation, which was decreased by LY294002 (AKT inhibitor) and U0126 (ERK inhibitor) in rat cardiac fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	AKT serine/threonine kinase 1	Rattus norvegicus	167-170
21255641-3	2011	LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, inhibited Akt activation and induced apoptotic cell death in cells expressing JAK2 V617F mutant and EpoR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	66-69
21255641-3	2011	LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, inhibited Akt activation and induced apoptotic cell death in cells expressing JAK2 V617F mutant and EpoR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Janus kinase 2	Mus musculus	134-138
21255641-3	2011	LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, inhibited Akt activation and induced apoptotic cell death in cells expressing JAK2 V617F mutant and EpoR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	erythropoietin receptor	Mus musculus	156-160
21354814-10	2011	Furthermore, LY-294002, PI3K inhibitor, reduced the TNF-alpha production enhanced by Cl-IB-MECA, although the phosphorylation status of Akt did not change in cells treated with LPS+Cl-IB-MECA than LPS alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-22	tumor necrosis factor	Homo sapiens	52-61
21376708-7	2011	Epo at 0.4 and 4 u/ml significantly decreased the fluorescence ratio in this condition, and this effect was attenuated by the phosphoinositide 3-kinase (PI3K) inhibitors, LY 294002 and wortmannin, and the Ca-activated K channel blocker, iberiotoxin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-180	erythropoietin	Rattus norvegicus	0-3
20518848-7	2011	Treatment with LY294002 decreased Rac1 activity as well as TNF-alpha expression stimulated by LPS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	Rac family small GTPase 1	Mus musculus	34-38
20518848-7	2011	Treatment with LY294002 decreased Rac1 activity as well as TNF-alpha expression stimulated by LPS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	tumor necrosis factor	Mus musculus	59-68
21614693-7	2011	In comparison with the other two groups, LY294002+SN50 group exhibited more severe apoptosis, with expression of Bcl-2 decreased and that of P53 and Bax increased more significantly(P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	B cell leukemia/lymphoma 2	Mus musculus	113-118
21614693-7	2011	In comparison with the other two groups, LY294002+SN50 group exhibited more severe apoptosis, with expression of Bcl-2 decreased and that of P53 and Bax increased more significantly(P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	transformation related protein 53, pseudogene	Mus musculus	141-144
21614693-7	2011	In comparison with the other two groups, LY294002+SN50 group exhibited more severe apoptosis, with expression of Bcl-2 decreased and that of P53 and Bax increased more significantly(P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	BCL2-associated X protein	Mus musculus	149-152
21787718-6	2011	The cadmium-induced increase in AKR1C3 protein levels was suppressed by N-acetylcysteine (NAC) and, to a lesser extent, PI3K inhibitor (Ly294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	aldo-keto reductase family 1 member C3	Homo sapiens	32-38
21198874-11	2011	The addition of NAC, PD98059, LY294002, NS398, and herbimycin A markedly inhibited the arecoline-induced HSP47 expression (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	serpin family H member 1	Homo sapiens	105-110
21198874-14	2011	In addition, arecoline-induced HSP47 expression was downregulated by NAC, PD98059, LY294002, NS398, and herbimycin A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	serpin family H member 1	Homo sapiens	31-36
21544242-8	2011	The AKT and ERK inhibitors, LY294002 and U0126, suppressed HIF-1alpha and VEGF expression and angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	4-7
21440529-10	2011	Inhibition of the Akt pathway with LY294002 paradoxically augmented MMP1 expression by reciprocal activation of ERK1/2 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	matrix metallopeptidase 1	Homo sapiens	68-72
21544242-8	2011	The AKT and ERK inhibitors, LY294002 and U0126, suppressed HIF-1alpha and VEGF expression and angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	mitogen-activated protein kinase 1	Homo sapiens	12-15
21544242-8	2011	The AKT and ERK inhibitors, LY294002 and U0126, suppressed HIF-1alpha and VEGF expression and angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-69
21544242-8	2011	The AKT and ERK inhibitors, LY294002 and U0126, suppressed HIF-1alpha and VEGF expression and angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	vascular endothelial growth factor A	Homo sapiens	74-78
21402888-5	2011	Accordingly, silencing of SHIP-1 led to loss of microvilli and ezrin/radixin/moesin phosphorylation, which could not be rescued by the PI3K inhibitor Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	inositol polyphosphate-5-phosphatase D	Homo sapiens	26-32
21300060-6	2011	Selective inhibition of PI3K/Akt using LY294002 or wortmannin in these cells increases serum starvation-induced HEK293 cell apoptosis with a concomitant decrease in cell proliferation and higher caspase-3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	29-32
21300060-6	2011	Selective inhibition of PI3K/Akt using LY294002 or wortmannin in these cells increases serum starvation-induced HEK293 cell apoptosis with a concomitant decrease in cell proliferation and higher caspase-3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	caspase 3	Homo sapiens	195-204
21472003-4	2011	Inhibition of PI3K/Akt by LY294002 significantly enhanced PEITC-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	19-22
21492439-5	2011	Biphasic activation of both pathways was suppressed by the selective inhibitor, Ly294002 for PI3K and U0126 for MAPK kinase (MEK1/2), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	mitogen-activated protein kinase kinase 1	Homo sapiens	125-131
21494560-4	2011	The ptenb MO-induced convergence defect could be rescued by a PI3-kinase inhibitor, LY294002 and by overexpressing dominant negative Cdc42.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	phosphatase and tensin homolog B	Danio rerio	4-9
21468084-7	2011	Further, the over-expression of LPS-induced IL-8 mRNA in HUVECs was suppressed by a p38 MAPK inhibitor (SB203580, 25 mumol/L) or a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002, 50 mumol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
21295016-7	2011	Inactivation of Akt pathway by the PI3K inhibitor LY294002 blocked the expression of HSP27 and HSP70 induced by FLZ.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	16-19
21295016-7	2011	Inactivation of Akt pathway by the PI3K inhibitor LY294002 blocked the expression of HSP27 and HSP70 induced by FLZ.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	heat shock protein family B (small) member 1	Homo sapiens	85-90
21295016-7	2011	Inactivation of Akt pathway by the PI3K inhibitor LY294002 blocked the expression of HSP27 and HSP70 induced by FLZ.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	heat shock protein family A (Hsp70) member 4	Homo sapiens	95-100
21166654-2	2011	PI3K inhibitor, LY294002 significantly reduced IL-1beta-induced IL-6 production in A549 cells but not in RASF, indicating that IL-1beta-induced IL-6 production was partially mediated by PI3Kin A549 cells but not in RASF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	interleukin 1 beta	Homo sapiens	127-135
20525806-12	2011	The phosphatidylinositol 3-kinase inhibitor LY294002 diminished the acrolein-induced increased CLDN5 transcript.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	claudin 5	Homo sapiens	95-100
21352809-8	2011	The phosphorylation of Akt, PI3K and eNOS were up-regulated by oxLDL, which was attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	AKT serine/threonine kinase 1	Homo sapiens	23-26
21352809-8	2011	The phosphorylation of Akt, PI3K and eNOS were up-regulated by oxLDL, which was attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	nitric oxide synthase 3	Homo sapiens	37-41
21166654-2	2011	PI3K inhibitor, LY294002 significantly reduced IL-1beta-induced IL-6 production in A549 cells but not in RASF, indicating that IL-1beta-induced IL-6 production was partially mediated by PI3Kin A549 cells but not in RASF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	interleukin 1 beta	Homo sapiens	47-55
21106690-6	2011	The ability of insulin to regulate ENaC function is dependent on the enzyme phosphoinositide 3-kinase since treatment with the inhibitor LY294002 (10 muM) abolished insulin-induced changes in ENaC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	insulin	Homo sapiens	15-22
21106690-6	2011	The ability of insulin to regulate ENaC function is dependent on the enzyme phosphoinositide 3-kinase since treatment with the inhibitor LY294002 (10 muM) abolished insulin-induced changes in ENaC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	35-39
21106690-6	2011	The ability of insulin to regulate ENaC function is dependent on the enzyme phosphoinositide 3-kinase since treatment with the inhibitor LY294002 (10 muM) abolished insulin-induced changes in ENaC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	insulin	Homo sapiens	165-172
21106690-6	2011	The ability of insulin to regulate ENaC function is dependent on the enzyme phosphoinositide 3-kinase since treatment with the inhibitor LY294002 (10 muM) abolished insulin-induced changes in ENaC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	192-196
21166654-2	2011	PI3K inhibitor, LY294002 significantly reduced IL-1beta-induced IL-6 production in A549 cells but not in RASF, indicating that IL-1beta-induced IL-6 production was partially mediated by PI3Kin A549 cells but not in RASF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	interleukin 6	Homo sapiens	64-68
21166654-2	2011	PI3K inhibitor, LY294002 significantly reduced IL-1beta-induced IL-6 production in A549 cells but not in RASF, indicating that IL-1beta-induced IL-6 production was partially mediated by PI3Kin A549 cells but not in RASF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	interleukin 6	Homo sapiens	144-148
21215800-6	2011	ERK1/2 activation was unaffected by the phosphatidylinositol 3-kinase inhibitor LY-294002, but was sensitive to inhibitors of Src kinase, phospholipase C and Gbetagamma subunit signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-89	mitogen-activated protein kinase 3	Homo sapiens	0-6
21166654-5	2011	Furthermore, the combination of IRAK4 siRNA and LY294002 treatment decreased protein induction level of IL-6 in A549 cells compared with that of IRAK4 siRNA or LY294002 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	interleukin 6	Homo sapiens	104-108
21166654-5	2011	Furthermore, the combination of IRAK4 siRNA and LY294002 treatment decreased protein induction level of IL-6 in A549 cells compared with that of IRAK4 siRNA or LY294002 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	interleukin 1 receptor associated kinase 4	Homo sapiens	32-37
21166654-5	2011	Furthermore, the combination of IRAK4 siRNA and LY294002 treatment decreased protein induction level of IL-6 in A549 cells compared with that of IRAK4 siRNA or LY294002 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	interleukin 6	Homo sapiens	104-108
21270124-8	2011	Leptin/CCK-8 synergistically stimulated a 7.7-fold increase in phosphorylated STAT3 (pSTAT3), which was inhibited by AG490, C3 transferase, PP2, LY294002, and wortmannin, but not PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	leptin	Rattus norvegicus	0-6
21496122-5	2011	LY294002, an inhibitor of phosphatidylinositol 3-kinase that initiates Akt-catalysed phosphorylation of eNOS on Ser1179, was administered 1 h before the induction of SCI; 24 h after SCI sections were taken for histological examination and for biochemical studies.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	71-74
21496122-6	2011	In this study we clearly demonstrated that pre-treatment with LY294002 reversed the increased activation of eNOS and Akt observed following SCI, and developed a severe trauma characterized by oedema, tissue damage and apoptosis (measured by TUNEL staining, Bax, Bcl-2 and Fas-L expression).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	thymoma viral proto-oncogene 1	Mus musculus	117-120
21496122-6	2011	In this study we clearly demonstrated that pre-treatment with LY294002 reversed the increased activation of eNOS and Akt observed following SCI, and developed a severe trauma characterized by oedema, tissue damage and apoptosis (measured by TUNEL staining, Bax, Bcl-2 and Fas-L expression).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	BCL2-associated X protein	Mus musculus	257-260
21496122-6	2011	In this study we clearly demonstrated that pre-treatment with LY294002 reversed the increased activation of eNOS and Akt observed following SCI, and developed a severe trauma characterized by oedema, tissue damage and apoptosis (measured by TUNEL staining, Bax, Bcl-2 and Fas-L expression).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	B cell leukemia/lymphoma 2	Mus musculus	262-267
21496122-6	2011	In this study we clearly demonstrated that pre-treatment with LY294002 reversed the increased activation of eNOS and Akt observed following SCI, and developed a severe trauma characterized by oedema, tissue damage and apoptosis (measured by TUNEL staining, Bax, Bcl-2 and Fas-L expression).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	Fas ligand (TNF superfamily, member 6)	Mus musculus	272-277
21187157-2	2011	R1881 blocked LY294002-induced apoptosis through the inhibition of Bak activation via an increase in Bcl-xL transcription and protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	BCL2 like 1	Homo sapiens	101-107
21187157-4	2011	Pharmacological inhibition of the Pim-1 kinase activity with quercetagetin, a highly selective Pim-1 inhibitor, prevented R1881-mediated increase in Bad phosphorylation and restored cell sensitivity to LY294002-induced apoptosis despite the increase in Bcl-xL expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
21187157-4	2011	Pharmacological inhibition of the Pim-1 kinase activity with quercetagetin, a highly selective Pim-1 inhibitor, prevented R1881-mediated increase in Bad phosphorylation and restored cell sensitivity to LY294002-induced apoptosis despite the increase in Bcl-xL expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	95-100
21187157-5	2011	These results demonstrate for the first time that the inhibition of LY294002-induced apoptosis by androgen is a function of an androgen receptor-dependent genomic signaling pathway leading to an increase in Bcl-xL expression as well as a non-genomic, Pim-1-dependent, signaling pathway mediated via phosphorylation of Bad at ser75.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	BCL2 like 1	Homo sapiens	207-213
21187157-5	2011	These results demonstrate for the first time that the inhibition of LY294002-induced apoptosis by androgen is a function of an androgen receptor-dependent genomic signaling pathway leading to an increase in Bcl-xL expression as well as a non-genomic, Pim-1-dependent, signaling pathway mediated via phosphorylation of Bad at ser75.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	251-256
21310961-5	2011	In HEK293T cells, insulin and constitutively active mutants of small GTPase H-Ras and PI3K could induce HM phosphorylation of both AKT mutants, which was blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	insulin	Homo sapiens	18-25
21310961-5	2011	In HEK293T cells, insulin and constitutively active mutants of small GTPase H-Ras and PI3K could induce HM phosphorylation of both AKT mutants, which was blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	HRas proto-oncogene, GTPase	Homo sapiens	76-81
21310961-5	2011	In HEK293T cells, insulin and constitutively active mutants of small GTPase H-Ras and PI3K could induce HM phosphorylation of both AKT mutants, which was blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	AKT serine/threonine kinase 1	Homo sapiens	131-134
21270124-8	2011	Leptin/CCK-8 synergistically stimulated a 7.7-fold increase in phosphorylated STAT3 (pSTAT3), which was inhibited by AG490, C3 transferase, PP2, LY294002, and wortmannin, but not PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	cholecystokinin	Rattus norvegicus	7-10
21270124-8	2011	Leptin/CCK-8 synergistically stimulated a 7.7-fold increase in phosphorylated STAT3 (pSTAT3), which was inhibited by AG490, C3 transferase, PP2, LY294002, and wortmannin, but not PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	signal transducer and activator of transcription 3	Rattus norvegicus	78-83
21327539-7	2011	PI3K inhibitor LY294002 significantly attenuated Rg1-enhanced VEGF expression and capillary density.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	vascular endothelial growth factor A	Rattus norvegicus	62-66
20857409-7	2011	Also, inhibitors of KIT downstream effectors, U0126 that blocks MEK1/2 as well as wortmannin and LY294002 that inhibit phosphatidylinositol 3-kinase-dependent AKT phosphorylation, inhibited the proliferation of MCC-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	20-23
20857409-7	2011	Also, inhibitors of KIT downstream effectors, U0126 that blocks MEK1/2 as well as wortmannin and LY294002 that inhibit phosphatidylinositol 3-kinase-dependent AKT phosphorylation, inhibited the proliferation of MCC-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	159-162
20857409-7	2011	Also, inhibitors of KIT downstream effectors, U0126 that blocks MEK1/2 as well as wortmannin and LY294002 that inhibit phosphatidylinositol 3-kinase-dependent AKT phosphorylation, inhibited the proliferation of MCC-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	MCC regulator of WNT signaling pathway	Homo sapiens	211-216
20857402-5	2011	Furthermore, treatment with extracellular signal-related kinase (ERK) inhibitor (PD98059) and dominant negative Ras (RasN17) abolished homocysteine-induced cyclin A expression; and treatment with phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) and mammalian target of rapamycin (mTOR) inhibitor (rapamycin) attenuated the homocysteine-induced cyclin D1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	244-252	mitogen-activated protein kinase 1	Homo sapiens	28-63
20857402-5	2011	Furthermore, treatment with extracellular signal-related kinase (ERK) inhibitor (PD98059) and dominant negative Ras (RasN17) abolished homocysteine-induced cyclin A expression; and treatment with phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) and mammalian target of rapamycin (mTOR) inhibitor (rapamycin) attenuated the homocysteine-induced cyclin D1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	244-252	mitogen-activated protein kinase 1	Homo sapiens	65-68
20857402-5	2011	Furthermore, treatment with extracellular signal-related kinase (ERK) inhibitor (PD98059) and dominant negative Ras (RasN17) abolished homocysteine-induced cyclin A expression; and treatment with phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) and mammalian target of rapamycin (mTOR) inhibitor (rapamycin) attenuated the homocysteine-induced cyclin D1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	244-252	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	196-225
21138475-5	2011	Treatment with Akt inhibitors (LY 294002, wortmannin) plus melatonin reduced p-Akt expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-40	thymoma viral proto-oncogene 1	Mus musculus	15-18
21282198-7	2011	Sal B and Tan IIA mediated vasodilatation in mice coronaries ex vivo, the effect of which was decreased with either L-NAME or PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	ATPase, class II, type 9A	Mus musculus	14-17
21138475-5	2011	Treatment with Akt inhibitors (LY 294002, wortmannin) plus melatonin reduced p-Akt expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-40	thymoma viral proto-oncogene 1	Mus musculus	79-82
20717763-12	2011	IL-6 up-regulated the levels of phosphorylated STAT3 and Akt, and this was blocked by AG490 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	interleukin 6	Homo sapiens	0-4
20717763-12	2011	IL-6 up-regulated the levels of phosphorylated STAT3 and Akt, and this was blocked by AG490 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	signal transducer and activator of transcription 3	Homo sapiens	47-52
20717763-12	2011	IL-6 up-regulated the levels of phosphorylated STAT3 and Akt, and this was blocked by AG490 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	AKT serine/threonine kinase 1	Homo sapiens	57-60
21320517-5	2011	And inhibition of phosphatidylinositol-3-kinase (PI3K)/Akt cascade by LY294002 and wortmannin significantly blocked the protective effects of PQQ, and alleviated the increase in Bcl-2/Bax ratio.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Homo sapiens	55-58
21282198-9	2011	Sal B and Tan IIA also stimulated eNOS phosphorylation in a concentration- and time-dependent manner in the HUVEC culture, which was diminished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	ATPase, class II, type 9A	Mus musculus	14-17
21320517-5	2011	And inhibition of phosphatidylinositol-3-kinase (PI3K)/Akt cascade by LY294002 and wortmannin significantly blocked the protective effects of PQQ, and alleviated the increase in Bcl-2/Bax ratio.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	BCL2 apoptosis regulator	Homo sapiens	178-183
21282198-9	2011	Sal B and Tan IIA also stimulated eNOS phosphorylation in a concentration- and time-dependent manner in the HUVEC culture, which was diminished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	nitric oxide synthase 3, endothelial cell	Mus musculus	34-38
21320517-5	2011	And inhibition of phosphatidylinositol-3-kinase (PI3K)/Akt cascade by LY294002 and wortmannin significantly blocked the protective effects of PQQ, and alleviated the increase in Bcl-2/Bax ratio.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	BCL2 associated X, apoptosis regulator	Homo sapiens	184-187
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	coagulation factor II, thrombin	Homo sapiens	0-8
21284537-9	2011	Akt phosphorylation was inhibited by the PI3K inhibitor, LY294002, but not by the specific estrogen receptor antagonist, fulvestrant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	0-3
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	22-27
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
21266580-3	2011	Thrombin-induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor (LY294002), an Akt inhibitor (1-L-6-hydroxymethyl-chiro-inositol-2-((R)-2-O-methyl-3-O-octadecylcarbonate)), and the dominant negative mutants of Rac1 (RacN17) and Akt (AktDN).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	C-X-C motif chemokine ligand 8	Homo sapiens	45-50
21266580-5	2011	The thrombin-induced increase in Akt activation was inhibited by RacN17 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	coagulation factor II, thrombin	Homo sapiens	4-12
21266580-6	2011	Stimulation of cells with thrombin resulted in increases in IKKalpha/beta activation and kappaB-luciferase activity; these effects were inhibited by RacN17, LY294002, an Akt inhibitor, and AktDN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	coagulation factor II, thrombin	Homo sapiens	26-34
21266580-6	2011	Stimulation of cells with thrombin resulted in increases in IKKalpha/beta activation and kappaB-luciferase activity; these effects were inhibited by RacN17, LY294002, an Akt inhibitor, and AktDN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	60-68
21073657-9	2011	PD98059 (a MEK1 inhibitor) or LY294002 (a PI3K inhibitors) decreased the up-regulation of PCNA expression and the increase of the cell proliferation index induced by hypoxia and GdCl(3) in PASMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	proliferating cell nuclear antigen	Rattus norvegicus	90-94
21406404-8	2011	EZH2-induced BRCA1 nuclear export, aneuploidy, and mitotic defects were prevented by treatment with the PI3K inhibitors LY294002 or wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
21406404-8	2011	EZH2-induced BRCA1 nuclear export, aneuploidy, and mitotic defects were prevented by treatment with the PI3K inhibitors LY294002 or wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	BRCA1 DNA repair associated	Homo sapiens	13-18
21193390-7	2011	The increase in FBLN5 mRNA levels observed in hypoxic cells was blocked by inhibitors of the PI3K/Akt/mTOR pathway (LY294002 and rapamycin) and mimicked by dimethyl oxal glycine, which prevents proline hydroxylase-mediated degradation of HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	fibulin 5	Homo sapiens	16-21
21193390-7	2011	The increase in FBLN5 mRNA levels observed in hypoxic cells was blocked by inhibitors of the PI3K/Akt/mTOR pathway (LY294002 and rapamycin) and mimicked by dimethyl oxal glycine, which prevents proline hydroxylase-mediated degradation of HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	98-101
21193390-7	2011	The increase in FBLN5 mRNA levels observed in hypoxic cells was blocked by inhibitors of the PI3K/Akt/mTOR pathway (LY294002 and rapamycin) and mimicked by dimethyl oxal glycine, which prevents proline hydroxylase-mediated degradation of HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	mechanistic target of rapamycin kinase	Homo sapiens	102-106
21199670-4	2011	The results showed that PTTH-stimulated ecdysteroidogenesis was partially blocked by LY294002 and wortmannin, indicating that PI3K is involved in PTTH-stimulated ecdysteroidogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	prothoracicotropic hormone	Bombyx mori	24-28
21070853-5	2011	The expression of ApoE and ABCA1 induced by synthetic or natural LXR ligands [TO901317, GW3965, and 22-(R)-hydroxycholesterol (22-(R)-HC), respectively] was attenuated by inhibitors of c-Jun N-terminal kinase (JNK) (curcumin and SP600125) and phosphoinositide 3-kinase (PI3K) (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	apolipoprotein E	Homo sapiens	18-22
21070853-5	2011	The expression of ApoE and ABCA1 induced by synthetic or natural LXR ligands [TO901317, GW3965, and 22-(R)-hydroxycholesterol (22-(R)-HC), respectively] was attenuated by inhibitors of c-Jun N-terminal kinase (JNK) (curcumin and SP600125) and phosphoinositide 3-kinase (PI3K) (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	ATP binding cassette subfamily A member 1	Homo sapiens	27-32
21239435-3	2011	The phosphatidylinositol 3 kinase (PI3K)/Akt pathway is involved in beta-catenin-dependent signaling, and pretreatment of these human ovarian cancer cells with a PI3K/Akt inhibitor, LY294002, attenuated GnRH-II-stimulated phosphorylation of GSK3beta and inhibited GnRH-II-induced invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	AKT serine/threonine kinase 1	Homo sapiens	41-44
21239435-3	2011	The phosphatidylinositol 3 kinase (PI3K)/Akt pathway is involved in beta-catenin-dependent signaling, and pretreatment of these human ovarian cancer cells with a PI3K/Akt inhibitor, LY294002, attenuated GnRH-II-stimulated phosphorylation of GSK3beta and inhibited GnRH-II-induced invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	catenin beta 1	Homo sapiens	68-80
21239435-6	2011	When OVCAR-3 and CaOV-3 cells were treated with GnRH-II, MT1-MMP levels increased approximately 3-fold, whereas siRNA-mediated depletion of GnRH receptor or pretreatment with LY294002 abrogated this.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	gonadotropin releasing hormone 2	Homo sapiens	48-55
20927568-7	2011	Although LA activated the phosphatidylinositol-3-kinase (PI3-kinase)/Akt pathway in HUVECs, inhibition of Akt by LY294002 did not affect inhibition of TNFalpha-induced IkappaBalpha degradation by LA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Homo sapiens	106-109
21215400-8	2011	The PI3 kinase inhibitor LY294002, but not the Src kinase inhibitor PP1 or the Galphai/o inhibitor pertussis toxin, inhibited modified LDL uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	peptidase inhibitor 3	Homo sapiens	4-7
21215400-10	2011	The AcLDL-induced IL-8 production was inhibited by LY294002 and filipin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
21205080-3	2011	Both medoxyprogesterone acetate (MPA) and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, were assayed for their effects on the proliferation of progestin-sensitive and progestin-resistant cancer cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	54-83
21205080-5	2011	Inhibiting the PI3K/Akt pathway by LY294002 upregulated PR expression and diminished cell growth, especially in progestin-resistant endometrial cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	20-23
21370247-7	2011	The inhibitory effect of ghrelin on caspase-3 activity was attenuated by inhibitors of ERK1/2 (PD98059), PI3K/Akt (LY294002) and growth hormone secretagogue receptor (GHSR)-1a (D-Lys(3) -growth hormone releasing peptide-6).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	caspase 3	Homo sapiens	36-45
21074412-5	2011	In both cell lines stimulated with endogenous or exogenous ligand, inhibition of MEK1/2 (with U0126 or PD98059) or PI3K (with PI-103 or LY294002) resulted in a marked reduction of EGFR-induced VEGF-A expression, whereas exogenous EGF-induced VEGF-C upregulation was blocked by inhibitors of MEK but not PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	mitogen-activated protein kinase kinase 1	Homo sapiens	81-87
21195590-7	2011	LY294002 (3mM) treatment showed delayed learning and decrease in Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
21199670-4	2011	The results showed that PTTH-stimulated ecdysteroidogenesis was partially blocked by LY294002 and wortmannin, indicating that PI3K is involved in PTTH-stimulated ecdysteroidogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	prothoracicotropic hormone	Bombyx mori	146-150
21199670-6	2011	PTTH-stimulated Akt phosphorylation was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	prothoracicotropic hormone	Bombyx mori	0-4
21199670-6	2011	PTTH-stimulated Akt phosphorylation was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	RAC serine/threonine-protein kinase	Bombyx mori	16-19
22811824-6	2011	PI3K specific inhibitor Ly294002 abolished such an effect of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	insulin	Homo sapiens	61-68
20857427-4	2011	The P13K inhibitors, Wortmannin and LY294002, suppressed both cell migration and akt activation in MPDL22, suggesting that the PI3K/akt pathway is involved in FGF-2-stimulated migration of MPDL22 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	fibroblast growth factor 2	Mus musculus	159-164
22811824-7	2011	pAkt were highly activated by insulin plus oxaliplatin and inhibited by addition of Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	insulin	Homo sapiens	30-37
21198637-7	2011	The transcriptional activator Sox18 was recruited to the MOR promoter in CHX-treated cells and this recruitment was also inhibited by the PI3-K and p38 MAPK inhibitors, Ly294002 and SB203580, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	SRY-box transcription factor 18	Homo sapiens	30-35
21198637-7	2011	The transcriptional activator Sox18 was recruited to the MOR promoter in CHX-treated cells and this recruitment was also inhibited by the PI3-K and p38 MAPK inhibitors, Ly294002 and SB203580, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	opioid receptor mu 1	Homo sapiens	57-60
21198637-7	2011	The transcriptional activator Sox18 was recruited to the MOR promoter in CHX-treated cells and this recruitment was also inhibited by the PI3-K and p38 MAPK inhibitors, Ly294002 and SB203580, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	mitogen-activated protein kinase 14	Homo sapiens	148-151
21163530-4	2011	Telomerase activity induced by EPO was significantly inhibited by AG490, PD98059, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	erythropoietin	Homo sapiens	31-34
21163530-7	2011	However, LY294002 did not inhibit c-myc or hTERT mRNA expression despite inhibiting STAT5 and AKT phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	signal transducer and activator of transcription 5A	Homo sapiens	84-89
21163530-7	2011	However, LY294002 did not inhibit c-myc or hTERT mRNA expression despite inhibiting STAT5 and AKT phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	94-97
21130731-6	2011	Inhibition of AKT activation by phosphoinocitide 3-kinase (PI3K) inhibitor LY294002 resulted in reduced Bcl-2 expression and enhanced Bax expression and thus induced apoptosis in the resistant cells, whereas inhibition of ERK1/2 activation by mitogen-activated protein kinase (MEK) inhibitor U0126 did not induce apoptosis without affecting the expression of Bcl-2 and Bax but decreased cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	AKT serine/threonine kinase 1	Homo sapiens	14-17
20108172-8	2011	While in vitro, treatment of LY294002 and transduction of mutant p27 (T157A) could diminish the expression of p-p27 Thr157 protein and arrest cells growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	zinc ribbon domain containing 2	Homo sapiens	65-68
20108172-8	2011	While in vitro, treatment of LY294002 and transduction of mutant p27 (T157A) could diminish the expression of p-p27 Thr157 protein and arrest cells growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	zinc ribbon domain containing 2	Homo sapiens	112-115
21184749-14	2011	We observed that H89, PD0998059, KN62 and LY294002 diminished BDNF-induced SS mRNA suggesting that BDNF-induced SS mRNA is mediated by the activation of cAMP/PKA, MAPK/ERKs, CaMK and PI3K pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	brain-derived neurotrophic factor	Rattus norvegicus	62-66
21184749-14	2011	We observed that H89, PD0998059, KN62 and LY294002 diminished BDNF-induced SS mRNA suggesting that BDNF-induced SS mRNA is mediated by the activation of cAMP/PKA, MAPK/ERKs, CaMK and PI3K pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	somatostatin	Rattus norvegicus	75-77
21184749-14	2011	We observed that H89, PD0998059, KN62 and LY294002 diminished BDNF-induced SS mRNA suggesting that BDNF-induced SS mRNA is mediated by the activation of cAMP/PKA, MAPK/ERKs, CaMK and PI3K pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	brain-derived neurotrophic factor	Rattus norvegicus	99-103
21350939-8	2011	The PI3-K inhibitor LY294002 abolished the TIMP-1-induced effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	TIMP metallopeptidase inhibitor 1	Homo sapiens	43-49
21426646-4	2011	VEGF concentrations in the SY5Y cell culture supernatants were measured using ELISA after the treatment with ATRA, BDNF, tyrosine kinase inhibitor K252a and PI3k inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	vascular endothelial growth factor A	Homo sapiens	0-4
21426646-10	2011	VEGF concentrations in the LY294002 treatment group (ATRA+LY294002+BDNF group) were also significantly lower than those in the group treated with ATRA+BDNF (P&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	vascular endothelial growth factor A	Homo sapiens	0-4
21426646-10	2011	VEGF concentrations in the LY294002 treatment group (ATRA+LY294002+BDNF group) were also significantly lower than those in the group treated with ATRA+BDNF (P&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	brain derived neurotrophic factor	Homo sapiens	67-71
21426646-10	2011	VEGF concentrations in the LY294002 treatment group (ATRA+LY294002+BDNF group) were also significantly lower than those in the group treated with ATRA+BDNF (P&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	vascular endothelial growth factor A	Homo sapiens	0-4
21426646-12	2011	The synthesis and secretion of VEGF can be inhibited by blocking TrkB-BDNF signal pathway with K252a or blocking the TrkB-BDNF downstream signal pathway PI3K/Akt with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	vascular endothelial growth factor A	Homo sapiens	31-35
21426646-12	2011	The synthesis and secretion of VEGF can be inhibited by blocking TrkB-BDNF signal pathway with K252a or blocking the TrkB-BDNF downstream signal pathway PI3K/Akt with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	AKT serine/threonine kinase 1	Homo sapiens	158-161
20956948-6	2011	Inhibition of Akt activity by small interfering RNA or LY294002 efficiently downregulated the Mre11 expression in CNE2 cells, and transfection with myr-Akt plasmid in HeLa cells upregulated the Mre11 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	14-17
20956948-6	2011	Inhibition of Akt activity by small interfering RNA or LY294002 efficiently downregulated the Mre11 expression in CNE2 cells, and transfection with myr-Akt plasmid in HeLa cells upregulated the Mre11 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	MRE11 homolog, double strand break repair nuclease	Homo sapiens	94-99
20956948-7	2011	In addition, luciferase reporter analysis revealed that Mre11 reporter activity increased after transfection with myr-Akt1 plasmids, and this myr-Akt1-induced transcriptional activity was blocked in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	MRE11 homolog, double strand break repair nuclease	Homo sapiens	56-61
20956948-7	2011	In addition, luciferase reporter analysis revealed that Mre11 reporter activity increased after transfection with myr-Akt1 plasmids, and this myr-Akt1-induced transcriptional activity was blocked in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	AKT serine/threonine kinase 1	Homo sapiens	118-122
20956948-7	2011	In addition, luciferase reporter analysis revealed that Mre11 reporter activity increased after transfection with myr-Akt1 plasmids, and this myr-Akt1-induced transcriptional activity was blocked in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	AKT serine/threonine kinase 1	Homo sapiens	146-150
21130731-6	2011	Inhibition of AKT activation by phosphoinocitide 3-kinase (PI3K) inhibitor LY294002 resulted in reduced Bcl-2 expression and enhanced Bax expression and thus induced apoptosis in the resistant cells, whereas inhibition of ERK1/2 activation by mitogen-activated protein kinase (MEK) inhibitor U0126 did not induce apoptosis without affecting the expression of Bcl-2 and Bax but decreased cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	BCL2 apoptosis regulator	Homo sapiens	104-109
21130731-6	2011	Inhibition of AKT activation by phosphoinocitide 3-kinase (PI3K) inhibitor LY294002 resulted in reduced Bcl-2 expression and enhanced Bax expression and thus induced apoptosis in the resistant cells, whereas inhibition of ERK1/2 activation by mitogen-activated protein kinase (MEK) inhibitor U0126 did not induce apoptosis without affecting the expression of Bcl-2 and Bax but decreased cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	BCL2 associated X, apoptosis regulator	Homo sapiens	134-137
21130731-6	2011	Inhibition of AKT activation by phosphoinocitide 3-kinase (PI3K) inhibitor LY294002 resulted in reduced Bcl-2 expression and enhanced Bax expression and thus induced apoptosis in the resistant cells, whereas inhibition of ERK1/2 activation by mitogen-activated protein kinase (MEK) inhibitor U0126 did not induce apoptosis without affecting the expression of Bcl-2 and Bax but decreased cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	mitogen-activated protein kinase kinase 7	Homo sapiens	243-275
21130731-6	2011	Inhibition of AKT activation by phosphoinocitide 3-kinase (PI3K) inhibitor LY294002 resulted in reduced Bcl-2 expression and enhanced Bax expression and thus induced apoptosis in the resistant cells, whereas inhibition of ERK1/2 activation by mitogen-activated protein kinase (MEK) inhibitor U0126 did not induce apoptosis without affecting the expression of Bcl-2 and Bax but decreased cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	mitogen-activated protein kinase kinase 7	Homo sapiens	277-280
21130731-6	2011	Inhibition of AKT activation by phosphoinocitide 3-kinase (PI3K) inhibitor LY294002 resulted in reduced Bcl-2 expression and enhanced Bax expression and thus induced apoptosis in the resistant cells, whereas inhibition of ERK1/2 activation by mitogen-activated protein kinase (MEK) inhibitor U0126 did not induce apoptosis without affecting the expression of Bcl-2 and Bax but decreased cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	BCL2 apoptosis regulator	Homo sapiens	359-364
21130731-6	2011	Inhibition of AKT activation by phosphoinocitide 3-kinase (PI3K) inhibitor LY294002 resulted in reduced Bcl-2 expression and enhanced Bax expression and thus induced apoptosis in the resistant cells, whereas inhibition of ERK1/2 activation by mitogen-activated protein kinase (MEK) inhibitor U0126 did not induce apoptosis without affecting the expression of Bcl-2 and Bax but decreased cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	BCL2 associated X, apoptosis regulator	Homo sapiens	369-372
21056559-5	2011	Inhibition of the upstream regulators of Akt or ERK1/2, i.e. phosphoinositide 3-kinase (PI3K; using wortmannin or LY294002) or MEK1/2 (using UO126 or PD98509), abrogated the respective phosphorylation responses, and significantly impaired pro-survival activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Homo sapiens	41-44
21180886-7	2011	The PI3K/Akt inhibitor, LY294002, significantly increased ATO-induced apoptosis (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Rattus norvegicus	9-12
21347252-7	2011	LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, blocked the protective effect of NK-4, and NK-4 caused activation of Akt/protein kinase B, a downstream effector of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	12-41
21347252-7	2011	LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, blocked the protective effect of NK-4, and NK-4 caused activation of Akt/protein kinase B, a downstream effector of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	129-132
21304902-11	2011	Akt knockdown, and inhibition of Akt signaling by LY294002 and mTOR inhibitor rapamycin reduced leptin expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	33-36
21304902-12	2011	Furthermore, treatment of LY294002 or rapamycin significantly suppressed AA-induced C/EBP alpha DNA-binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	CCAAT enhancer binding protein alpha	Homo sapiens	84-95
21368889-5	2011	When downstream signaling from IL-3 was blocked by LY294002 and/or dn-Stat5, Xbp1 expression was downregulated and IRE1 phosphorylation was suppressed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	interleukin 3	Mus musculus	31-35
21368889-5	2011	When downstream signaling from IL-3 was blocked by LY294002 and/or dn-Stat5, Xbp1 expression was downregulated and IRE1 phosphorylation was suppressed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	X-box binding protein 1	Mus musculus	77-81
21368889-5	2011	When downstream signaling from IL-3 was blocked by LY294002 and/or dn-Stat5, Xbp1 expression was downregulated and IRE1 phosphorylation was suppressed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	endoplasmic reticulum (ER) to nucleus signalling 2	Mus musculus	115-119
21350711-7	2011	AMD3100 and LY294002 inhibited the phosphorylation of PI3K/AKT and beta-catenin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Homo sapiens	59-62
21350711-7	2011	AMD3100 and LY294002 inhibited the phosphorylation of PI3K/AKT and beta-catenin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	catenin beta 1	Homo sapiens	67-79
21127289-4	2011	PAR1-induced formation of TxA(2) was inhibited by the phosphatidylinositol kinase inhibitor LY294002, whereas this inhibitor did not block 12-HETE biosynthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	coagulation factor II thrombin receptor	Homo sapiens	0-4
21054343-7	2011	Specifically, LY294002 and PI103 suppressed the mRNA expression levels of mitochondrial regulators nuclear respiratory factors 1 and 2 (NRF1 and NRF2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	nuclear respiratory factor 1	Homo sapiens	136-140
21054343-7	2011	Specifically, LY294002 and PI103 suppressed the mRNA expression levels of mitochondrial regulators nuclear respiratory factors 1 and 2 (NRF1 and NRF2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
21054343-11	2011	Finally, we partially blunted the LY294002-mediated growth suppression by using an antioxidant or over-expressing PGC-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	PPARG coactivator 1 beta	Homo sapiens	114-123
21180886-13	2011	The PI3K/Akt inhibitor, LY294002, re-sensitized Cbl-b (DN) overexpressing cells to ATO and reversed G2/M arrest (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Rattus norvegicus	9-12
21180886-13	2011	The PI3K/Akt inhibitor, LY294002, re-sensitized Cbl-b (DN) overexpressing cells to ATO and reversed G2/M arrest (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	Cbl proto-oncogene B	Rattus norvegicus	48-53
21129803-6	2011	However, in the presence of LY294002, cell growth was still promoted by insulin and glargine relative to LY294002-treated group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	insulin	Homo sapiens	72-79
20843299-8	2011	Protein expression of AKT and phosphorylated AKT in CMECs was measured by Western blot after exposure to various concentrations of ghrelin and the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
20843299-8	2011	Protein expression of AKT and phosphorylated AKT in CMECs was measured by Western blot after exposure to various concentrations of ghrelin and the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	AKT serine/threonine kinase 1	Rattus norvegicus	45-48
20843299-10	2011	However, addition of the PI3K/AKT inhibitor LY294002 inhibited the ghrelin-mediated enhancement in cell proliferation (0.227+-0.042 compared with 0.199+-0.021, P = 0.15).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Rattus norvegicus	30-33
21129803-7	2011	Accordingly, LY294002 profoundly reduced protein levels of pAkt, while insulin and glargine increased pAkt in T24 cells pretreated with LY294002 as compared with cells treated with LY294002 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	insulin	Homo sapiens	71-78
21129803-7	2011	Accordingly, LY294002 profoundly reduced protein levels of pAkt, while insulin and glargine increased pAkt in T24 cells pretreated with LY294002 as compared with cells treated with LY294002 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	insulin	Homo sapiens	71-78
21270272-6	2011	Moreover, insulin increased Nrf2 transcriptional activity, which was blocked by LY294002 but enhanced by U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	nuclear factor, erythroid derived 2, like 2	Mus musculus	28-32
21147878-8	2011	Insulin caused a significant increase in HO-1 expression that was time- and dose-dependent, and this effect was blocked by inhibition of phosphatidylinositol 3 (PI3)-kinase activation using LY294002 (50 muM) or of protein kinase C activation using Ro-318220 (2 muM), but not by an Akt inhibitor, triciribine (10 muM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	heme oxygenase 1	Rattus norvegicus	41-45
21147878-8	2011	Insulin caused a significant increase in HO-1 expression that was time- and dose-dependent, and this effect was blocked by inhibition of phosphatidylinositol 3 (PI3)-kinase activation using LY294002 (50 muM) or of protein kinase C activation using Ro-318220 (2 muM), but not by an Akt inhibitor, triciribine (10 muM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	AKT serine/threonine kinase 1	Rattus norvegicus	281-284
21159855-8	2011	Furthermore, pretreatment of ISEMF cells with the phosphatidylinositol 3 kinase (PI3K) inhibitors, LY294002 and wortmannin, abrogated the IGF-I mRNA response to GLP-2, as did overexpression of kinase-dead Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	insulin-like growth factor 1	Mus musculus	138-143
21147878-9	2011	Furthermore, incubation of 3T3-L1 adipocytes with 100 nm insulin resulted in a significant decrease in levels of the miRNAs mir-155, mir-183, and mir-872, and this effect was also blocked by pretreatment with LY294002 or Ro-318220, but not triciribine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	209-217	microRNA 155	Rattus norvegicus	124-131
21159855-8	2011	Furthermore, pretreatment of ISEMF cells with the phosphatidylinositol 3 kinase (PI3K) inhibitors, LY294002 and wortmannin, abrogated the IGF-I mRNA response to GLP-2, as did overexpression of kinase-dead Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	glucagon-like peptide 2 receptor	Mus musculus	161-166
21147878-9	2011	Furthermore, incubation of 3T3-L1 adipocytes with 100 nm insulin resulted in a significant decrease in levels of the miRNAs mir-155, mir-183, and mir-872, and this effect was also blocked by pretreatment with LY294002 or Ro-318220, but not triciribine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	209-217	microRNA 872	Rattus norvegicus	146-153
21159855-8	2011	Furthermore, pretreatment of ISEMF cells with the phosphatidylinositol 3 kinase (PI3K) inhibitors, LY294002 and wortmannin, abrogated the IGF-I mRNA response to GLP-2, as did overexpression of kinase-dead Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	thymoma viral proto-oncogene 1	Mus musculus	205-208
21075101-8	2011	The effect of TNF-alpha was blocked by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	tumor necrosis factor	Homo sapiens	14-23
20930115-6	2011	Increases in cyclin D1 protein induced by FCS or LXA(4) were blocked by the PI3 kinase inhibitor, LY294002, and attenuated by FPR2 antagonism using Boc2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	cyclin D1	Homo sapiens	13-22
20473866-6	2011	The inhibition of PI3K signaling by LY 294002 was simultaneously reversed by transfection, accompanied by diminution of all trans-retinoic acid-induced upregulation of PTEN and enhancement of cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-45	phosphatase and tensin homolog	Homo sapiens	168-172
21240525-3	2011	Inhibition of PI3K/Akt pathway by chemical LY294002 or specific short hairpin RNA (shRNA) vector prevented SREBP-1 and TGF-beta1 up-regulation, as well as ameliorated HKC cells lipogenesis and extracellular matrix accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	19-22
21240525-3	2011	Inhibition of PI3K/Akt pathway by chemical LY294002 or specific short hairpin RNA (shRNA) vector prevented SREBP-1 and TGF-beta1 up-regulation, as well as ameliorated HKC cells lipogenesis and extracellular matrix accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	sterol regulatory element binding transcription factor 1	Homo sapiens	107-114
21240525-3	2011	Inhibition of PI3K/Akt pathway by chemical LY294002 or specific short hairpin RNA (shRNA) vector prevented SREBP-1 and TGF-beta1 up-regulation, as well as ameliorated HKC cells lipogenesis and extracellular matrix accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	transforming growth factor beta 1	Homo sapiens	119-128
21361663-4	2011	LY294002 loaded microspheres and 5-Aza-2-deoxycytidine are applied to MCF-10A cells for combinatory PI3K/AKT inhibition and deoxyribonucleic acid (DNA) demethylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	105-108
21136025-9	2011	In addition, the Cur3-induced increase in cell viability was attenuated by the treatment with wortmannin or LY294002, the upstream inhibitors of Akt, and was enhanced by the treatment with 2-[2"-amino-3"-methoxyphenyl]-oxanaphthalen-4-one (PD98059), an upstream inhibitor of ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Homo sapiens	145-148
21152864-8	2011	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed IL-1ss- and TNF-alpha-induced IL-32alpha mRNA expression, although MAPK inhibitors had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	tumor necrosis factor	Homo sapiens	82-103
21152864-8	2011	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed IL-1ss- and TNF-alpha-induced IL-32alpha mRNA expression, although MAPK inhibitors had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	interleukin 32	Homo sapiens	112-122
20672289-9	2011	Additionally, thrombin-induced MLC phosphorylation was blocked by the inhibitory PKCzeta pseudosubstrate, wortmannin, and LY294002, indicating IP(3)/PKCzeta involvement in the control of MLC phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	coagulation factor II	Rattus norvegicus	14-22
21461238-6	2011	NAD(+)- and NADP(+)-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	C-C motif chemokine ligand 2	Homo sapiens	29-33
20975661-15	2011	Inhibition of PI3K/Akt signaling by LY294002 and wortmannin partially blocked the glucose-mediated rescue of cell apoptosis and barrier damage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
21560358-10	2011	p-Akt inhibitor LY294002 and RO813220 + LY294002 decreased p-aPKC(iotazeta) protein, p-Akt protein and positive cells, gamma-GCS protein and mRNA and activity expression, increased Nrf2 protein of cytoplasm expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Rattus norvegicus	2-5
21560358-10	2011	p-Akt inhibitor LY294002 and RO813220 + LY294002 decreased p-aPKC(iotazeta) protein, p-Akt protein and positive cells, gamma-GCS protein and mRNA and activity expression, increased Nrf2 protein of cytoplasm expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Rattus norvegicus	87-90
21560358-10	2011	p-Akt inhibitor LY294002 and RO813220 + LY294002 decreased p-aPKC(iotazeta) protein, p-Akt protein and positive cells, gamma-GCS protein and mRNA and activity expression, increased Nrf2 protein of cytoplasm expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Rattus norvegicus	87-90
21560358-10	2011	p-Akt inhibitor LY294002 and RO813220 + LY294002 decreased p-aPKC(iotazeta) protein, p-Akt protein and positive cells, gamma-GCS protein and mRNA and activity expression, increased Nrf2 protein of cytoplasm expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	119-128
21560358-10	2011	p-Akt inhibitor LY294002 and RO813220 + LY294002 decreased p-aPKC(iotazeta) protein, p-Akt protein and positive cells, gamma-GCS protein and mRNA and activity expression, increased Nrf2 protein of cytoplasm expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	119-128
21560358-10	2011	p-Akt inhibitor LY294002 and RO813220 + LY294002 decreased p-aPKC(iotazeta) protein, p-Akt protein and positive cells, gamma-GCS protein and mRNA and activity expression, increased Nrf2 protein of cytoplasm expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	NFE2 like bZIP transcription factor 2	Rattus norvegicus	181-185
21560358-10	2011	p-Akt inhibitor LY294002 and RO813220 + LY294002 decreased p-aPKC(iotazeta) protein, p-Akt protein and positive cells, gamma-GCS protein and mRNA and activity expression, increased Nrf2 protein of cytoplasm expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	181-185
21205894-12	2011	VEGF blockade, the PI3K-specific inhibitor LY294002, and the MAPK/ERK1/2 (MEK1/2)-specific inhibitor U0126 all markedly attenuated IL-25-induced angiogenesis, and the inhibitors also reduced IL-25-induced proliferation and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	interleukin 25	Homo sapiens	131-136
21270507-5	2011	The protective effect of clusterin on H2O2-induced apoptosis is impaired by PI3K inhibitor LY294002, which effectively suppresses clusterin-induced activation of Akt and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	clusterin	Rattus norvegicus	25-34
21270507-5	2011	The protective effect of clusterin on H2O2-induced apoptosis is impaired by PI3K inhibitor LY294002, which effectively suppresses clusterin-induced activation of Akt and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	clusterin	Rattus norvegicus	130-139
21270507-5	2011	The protective effect of clusterin on H2O2-induced apoptosis is impaired by PI3K inhibitor LY294002, which effectively suppresses clusterin-induced activation of Akt and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	AKT serine/threonine kinase 1	Rattus norvegicus	162-165
21270507-5	2011	The protective effect of clusterin on H2O2-induced apoptosis is impaired by PI3K inhibitor LY294002, which effectively suppresses clusterin-induced activation of Akt and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	glycogen synthase kinase 3 beta	Rattus norvegicus	170-179
21114978-8	2011	On the other hand, metformin induced Akt activation in cisplatin-treated cells and Akt inhibitor 10-DEBC hydrochloride or phosphoinositide 3-kinase/Akt inhibitor LY294002 abolished metformin-mediated antioxidant and antiapoptotic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	AKT serine/threonine kinase 1	Homo sapiens	37-40
21040800-10	2011	Inhibition of phosphatidylinositol 3-kinase (PI3K) with LY294002 attenuated the 14,15-EETs-induced activating phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	129-132
21114978-8	2011	On the other hand, metformin induced Akt activation in cisplatin-treated cells and Akt inhibitor 10-DEBC hydrochloride or phosphoinositide 3-kinase/Akt inhibitor LY294002 abolished metformin-mediated antioxidant and antiapoptotic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	AKT serine/threonine kinase 1	Homo sapiens	83-86
21224998-9	2011	The data analysis showed that eIF5A, MMP9, and PCNA expression decreased as a result of the inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	eukaryotic translation initiation factor 5A	Homo sapiens	30-35
21114978-8	2011	On the other hand, metformin induced Akt activation in cisplatin-treated cells and Akt inhibitor 10-DEBC hydrochloride or phosphoinositide 3-kinase/Akt inhibitor LY294002 abolished metformin-mediated antioxidant and antiapoptotic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	AKT serine/threonine kinase 1	Homo sapiens	83-86
20940001-11	2011	In addition, LY294002 diminished the effect of Postcond on the activation of CHOP, caspase-12 and GRP78.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	DNA-damage inducible transcript 3	Rattus norvegicus	77-81
20940001-11	2011	In addition, LY294002 diminished the effect of Postcond on the activation of CHOP, caspase-12 and GRP78.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	caspase 12	Rattus norvegicus	83-93
20940001-11	2011	In addition, LY294002 diminished the effect of Postcond on the activation of CHOP, caspase-12 and GRP78.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	98-103
21059898-6	2011	Akt was phosphorylated in HRECs by G-CSF addition, and LY294002, a PI3K inhibitor, significantly attenuated the antiapoptotic effect of G-CSF (by 44.1%, P &lt; .05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	colony stimulating factor 3	Homo sapiens	136-141
21245990-8	2011	In MKN45 and AGS cells, oxaliplatin treatment promoted both protein kinase B (Akt) and NFkappaB activation, while pretreatment with LY294002 significantly attenuated oxaliplatin-induced Akt activity and NFkappaB binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	protein tyrosine kinase 2 beta	Homo sapiens	60-76
21245990-8	2011	In MKN45 and AGS cells, oxaliplatin treatment promoted both protein kinase B (Akt) and NFkappaB activation, while pretreatment with LY294002 significantly attenuated oxaliplatin-induced Akt activity and NFkappaB binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	nuclear factor kappa B subunit 1	Homo sapiens	87-95
21245990-8	2011	In MKN45 and AGS cells, oxaliplatin treatment promoted both protein kinase B (Akt) and NFkappaB activation, while pretreatment with LY294002 significantly attenuated oxaliplatin-induced Akt activity and NFkappaB binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	AKT serine/threonine kinase 1	Homo sapiens	186-189
21245990-8	2011	In MKN45 and AGS cells, oxaliplatin treatment promoted both protein kinase B (Akt) and NFkappaB activation, while pretreatment with LY294002 significantly attenuated oxaliplatin-induced Akt activity and NFkappaB binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	nuclear factor kappa B subunit 1	Homo sapiens	203-211
21245990-9	2011	LY294002 promoted oxaliplatin-induced Fas ligand (FasL) expression, Fas-associated death domain protein recruitment, caspase-8, Bid, and caspase-3 activation, and the short form of cellular caspase-8/FLICE-inhibitory protein (c-FLIP(S)) inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Fas ligand	Homo sapiens	38-48
21245990-9	2011	LY294002 promoted oxaliplatin-induced Fas ligand (FasL) expression, Fas-associated death domain protein recruitment, caspase-8, Bid, and caspase-3 activation, and the short form of cellular caspase-8/FLICE-inhibitory protein (c-FLIP(S)) inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Fas ligand	Homo sapiens	50-54
21245990-9	2011	LY294002 promoted oxaliplatin-induced Fas ligand (FasL) expression, Fas-associated death domain protein recruitment, caspase-8, Bid, and caspase-3 activation, and the short form of cellular caspase-8/FLICE-inhibitory protein (c-FLIP(S)) inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Fas associated via death domain	Homo sapiens	68-103
21245990-9	2011	LY294002 promoted oxaliplatin-induced Fas ligand (FasL) expression, Fas-associated death domain protein recruitment, caspase-8, Bid, and caspase-3 activation, and the short form of cellular caspase-8/FLICE-inhibitory protein (c-FLIP(S)) inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 8	Homo sapiens	117-126
21245990-9	2011	LY294002 promoted oxaliplatin-induced Fas ligand (FasL) expression, Fas-associated death domain protein recruitment, caspase-8, Bid, and caspase-3 activation, and the short form of cellular caspase-8/FLICE-inhibitory protein (c-FLIP(S)) inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BH3 interacting domain death agonist	Homo sapiens	128-131
21245990-9	2011	LY294002 promoted oxaliplatin-induced Fas ligand (FasL) expression, Fas-associated death domain protein recruitment, caspase-8, Bid, and caspase-3 activation, and the short form of cellular caspase-8/FLICE-inhibitory protein (c-FLIP(S)) inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Homo sapiens	137-146
21245990-9	2011	LY294002 promoted oxaliplatin-induced Fas ligand (FasL) expression, Fas-associated death domain protein recruitment, caspase-8, Bid, and caspase-3 activation, and the short form of cellular caspase-8/FLICE-inhibitory protein (c-FLIP(S)) inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 8	Homo sapiens	190-199
21245990-9	2011	LY294002 promoted oxaliplatin-induced Fas ligand (FasL) expression, Fas-associated death domain protein recruitment, caspase-8, Bid, and caspase-3 activation, and the short form of cellular caspase-8/FLICE-inhibitory protein (c-FLIP(S)) inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CASP8 and FADD like apoptosis regulator	Homo sapiens	226-232
21245990-10	2011	In vivo, LY294002 inhibited oxaliplatin-induced activation of Akt and NFkappaB, and increased oxaliplatin-induced expression of FasL, inhibition of c-FLIP(S), and activation of caspase-8, Bid, and caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	62-65
21245990-10	2011	In vivo, LY294002 inhibited oxaliplatin-induced activation of Akt and NFkappaB, and increased oxaliplatin-induced expression of FasL, inhibition of c-FLIP(S), and activation of caspase-8, Bid, and caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	nuclear factor kappa B subunit 1	Homo sapiens	70-78
21245990-10	2011	In vivo, LY294002 inhibited oxaliplatin-induced activation of Akt and NFkappaB, and increased oxaliplatin-induced expression of FasL, inhibition of c-FLIP(S), and activation of caspase-8, Bid, and caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	Fas ligand	Homo sapiens	128-132
21245990-10	2011	In vivo, LY294002 inhibited oxaliplatin-induced activation of Akt and NFkappaB, and increased oxaliplatin-induced expression of FasL, inhibition of c-FLIP(S), and activation of caspase-8, Bid, and caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	CASP8 and FADD like apoptosis regulator	Homo sapiens	148-154
21245990-10	2011	In vivo, LY294002 inhibited oxaliplatin-induced activation of Akt and NFkappaB, and increased oxaliplatin-induced expression of FasL, inhibition of c-FLIP(S), and activation of caspase-8, Bid, and caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	caspase 8	Homo sapiens	177-186
21245990-10	2011	In vivo, LY294002 inhibited oxaliplatin-induced activation of Akt and NFkappaB, and increased oxaliplatin-induced expression of FasL, inhibition of c-FLIP(S), and activation of caspase-8, Bid, and caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	BH3 interacting domain death agonist	Homo sapiens	188-191
21245990-10	2011	In vivo, LY294002 inhibited oxaliplatin-induced activation of Akt and NFkappaB, and increased oxaliplatin-induced expression of FasL, inhibition of c-FLIP(S), and activation of caspase-8, Bid, and caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	caspase 3	Homo sapiens	197-206
21253589-5	2011	The PI3K inhibitor LY294002 and a dominant-negative inactive kinase-domain mutant of Akt both inhibited TGFbeta-stimulated myofibroblast differentiation, as determined by Western blotting for alpha-smooth muscle actin and calponin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	transforming growth factor beta 1	Homo sapiens	104-111
21224998-9	2011	The data analysis showed that eIF5A, MMP9, and PCNA expression decreased as a result of the inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	matrix metallopeptidase 9	Homo sapiens	37-41
21224998-9	2011	The data analysis showed that eIF5A, MMP9, and PCNA expression decreased as a result of the inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	proliferating cell nuclear antigen	Homo sapiens	47-51
20958264-6	2011	Glucose uptake and lipogenesis were severely blocked by knocking-down of PFKFB2 using siRNA (small interfering RNA) or by inhibition of PFK-2 activity with LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	136-141
21224070-9	2011	Furthermore, the antitumoral effect obtained after treatment with a combination of rapamycin and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 was more significant than with rapamycin alone in both cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	97-126
20934465-6	2011	Akt phosphorylation was inhibited by the PI3K inhibitor LY294002 (10muM), farnyltranferase inhibitor FTI-276, or transfection with a dominant negative Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	0-3
20934465-7	2011	The cyclic AMP-induced suppression of cytokine-stimulated iNOS was partially reversed by LY294002 and FTI-276.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	nitric oxide synthase 2	Homo sapiens	58-62
20934465-9	2011	Cyclic AMP increased phosphorylation of Raf1 at serine 259 which was blocked by LY294002 and associated with decreased MAPK P44/42 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	40-44
21720001-5	2011	The PDGF-induced ERK activation was abolished by AG1296 (10(-7) M) or LY294002 (10(-7) M) treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	Eph receptor B1	Rattus norvegicus	17-20
21126261-13	2011	The cardioprotective effect of rapamycin was blocked by the phosphatidylinositol 3-kinase (Akt) inhibitor LY294002 (15 nmol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
21691080-5	2011	Pharmacological inhibition of MEK or PI3-K using PD98059 (20muM) or LY294002 (5mum), resulted in significant reduction of overall cell migration distances of 38% (p&lt;0.001) and 39.5% (p&lt;0.0004), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	midkine	Mus musculus	30-33
21691080-5	2011	Pharmacological inhibition of MEK or PI3-K using PD98059 (20muM) or LY294002 (5mum), resulted in significant reduction of overall cell migration distances of 38% (p&lt;0.001) and 39.5% (p&lt;0.0004), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	37-40
21239735-7	2011	LY294002, a specific inhibitor of PI3K, blocked HBXIP-stimulated Akt phosphorylation and suppressed the cell cycle promotion induced by HBXIP in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	48-53
21566342-11	2011	The cell growth promoted by CYP3A4 was inhibited by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	28-34
21490406-5	2011	An analysis using a specific inhibitor of phosphatidylinositol-3-kinase (PI3K), LY294002, showed that ghrelin prevented apoptosis via the activation of PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	42-71
21490406-5	2011	An analysis using a specific inhibitor of phosphatidylinositol-3-kinase (PI3K), LY294002, showed that ghrelin prevented apoptosis via the activation of PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	ghrelin and obestatin prepropeptide	Rattus norvegicus	102-109
21490406-11	2011	In addition, phospho-Akt was translocated to the nucleus in response to ghrelin and PI3K inhibition by LY294002 prevented ghrelin-induced effect on phospho-Akt localization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	AKT serine/threonine kinase 1	Rattus norvegicus	21-24
21490406-11	2011	In addition, phospho-Akt was translocated to the nucleus in response to ghrelin and PI3K inhibition by LY294002 prevented ghrelin-induced effect on phospho-Akt localization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	ghrelin and obestatin prepropeptide	Rattus norvegicus	122-129
21490406-11	2011	In addition, phospho-Akt was translocated to the nucleus in response to ghrelin and PI3K inhibition by LY294002 prevented ghrelin-induced effect on phospho-Akt localization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	AKT serine/threonine kinase 1	Rattus norvegicus	156-159
21239735-7	2011	LY294002, a specific inhibitor of PI3K, blocked HBXIP-stimulated Akt phosphorylation and suppressed the cell cycle promotion induced by HBXIP in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	65-68
21239735-7	2011	LY294002, a specific inhibitor of PI3K, blocked HBXIP-stimulated Akt phosphorylation and suppressed the cell cycle promotion induced by HBXIP in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	136-141
21239735-8	2011	The increase in cyclinD(1) protein levels induced by HBXIP was inhibited when cells were incubated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	53-58
20809699-10	2011	The PI3K inhibitor, Ly294002, blocked ERK, NF-kappaB, and PKC theta activation and G-CSF mRNA expression in PBMC induced by PGM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	phosphoglycerate mutase-like protein	Glycine max	124-127
20430472-5	2011	The IL-32 expression was attenuated by PP2 (a Src-family kinase [SFK] inhibitor), rottlerin (a protein kinase [PK] Cdelta inhibitor), and LY294002 (a phosphatidylinositol 3-kinase [PI3K] inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	interleukin 32	Homo sapiens	4-9
20430472-5	2011	The IL-32 expression was attenuated by PP2 (a Src-family kinase [SFK] inhibitor), rottlerin (a protein kinase [PK] Cdelta inhibitor), and LY294002 (a phosphatidylinositol 3-kinase [PI3K] inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	150-179
21541882-9	2011	The phosphoinositol 3-kinase (PI3K)-specific inhibitor LY294002 abolished the cytoprotective effects induced by triphlorethol-A, suggesting that OGG1 restoration by triphlorethol-A is involved in the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	8-oxoguanine DNA glycosylase	Homo sapiens	145-149
21330835-7	2011	RESULTS: The combination of LY294002 and radiation resulted in significant and synergistic suppression of cervical cancer cells in a dose-dependent manner in clonogenic assays (P &lt; 0.05), higher ratio of apoptosis cells, and more remarkable reduction of Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	257-260
21330835-10	2011	CONCLUSIONS: Phosphoinositide-3-kinase inhibition by LY294002 can synergistically enhance radiation efficacy via dephosphorylation of Akt in cervical cancer, and PI3K inhibition alone can also suppress tumor regrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	13-38
21330835-10	2011	CONCLUSIONS: Phosphoinositide-3-kinase inhibition by LY294002 can synergistically enhance radiation efficacy via dephosphorylation of Akt in cervical cancer, and PI3K inhibition alone can also suppress tumor regrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	134-137
20947540-4	2011	The growth inhibitor LY294002 (2-10 muM) inhibited growth of both oestrogen-maintained and oestrogen-deprived cells with similar dose-responses, implying continued similar dependence on phosphoinositide 3-kinase (PI3K) pathways with no alteration after adaptation to oestrogen independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	latexin	Homo sapiens	36-39
21422731-6	2011	Inhibition studies using LY294002 (20 microM) revealed the requirement of the PI3K/Akt pathway for LPS-stimulated IL-6 production and NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	83-86
21422731-6	2011	Inhibition studies using LY294002 (20 microM) revealed the requirement of the PI3K/Akt pathway for LPS-stimulated IL-6 production and NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	interleukin 6	Homo sapiens	114-118
21422731-6	2011	Inhibition studies using LY294002 (20 microM) revealed the requirement of the PI3K/Akt pathway for LPS-stimulated IL-6 production and NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	nuclear factor kappa B subunit 1	Homo sapiens	134-143
21046563-9	2011	Blocking the PI3 kinase/Akt pathway using LY294002 reversed the neuroprotective effect of 3-BrPA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	AKT serine/threonine kinase 1	Rattus norvegicus	24-27
21541882-9	2011	The phosphoinositol 3-kinase (PI3K)-specific inhibitor LY294002 abolished the cytoprotective effects induced by triphlorethol-A, suggesting that OGG1 restoration by triphlorethol-A is involved in the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	205-208
21430412-5	2011	Further studies showed that PI3K inhibition using LY294002 leads to a decrease in PI3K substrate Akt and mitogen-activated protein kinase extracellular signal-regulated kinase and p38 phosphorylation/activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	97-100
21850177-5	2011	After the pretreatment with 30 muM of LY294002, a PI3-K/Akt pathway inhibitor, apoptosis was assessed by flow cytometry, protein levels of phospho-Akt and Akt were quantified by western blot, and cell localization of phospho-Akt was determined by immunofluorescence staining.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	56-59
21850177-5	2011	After the pretreatment with 30 muM of LY294002, a PI3-K/Akt pathway inhibitor, apoptosis was assessed by flow cytometry, protein levels of phospho-Akt and Akt were quantified by western blot, and cell localization of phospho-Akt was determined by immunofluorescence staining.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	147-150
21850177-5	2011	After the pretreatment with 30 muM of LY294002, a PI3-K/Akt pathway inhibitor, apoptosis was assessed by flow cytometry, protein levels of phospho-Akt and Akt were quantified by western blot, and cell localization of phospho-Akt was determined by immunofluorescence staining.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	147-150
21850177-5	2011	After the pretreatment with 30 muM of LY294002, a PI3-K/Akt pathway inhibitor, apoptosis was assessed by flow cytometry, protein levels of phospho-Akt and Akt were quantified by western blot, and cell localization of phospho-Akt was determined by immunofluorescence staining.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	147-150
21850177-7	2011	Moreover, effect of LY294002 on HSP70 expression was also examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	heat shock protein family A (Hsp70) member 4	Homo sapiens	32-37
21850177-9	2011	Furthermore, pretreatment of LY294002 inhibited the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	71-74
20153001-5	2011	In addition, phosphatidylinositol-3 kinase and Akt protein expressions were increased when C2C12 myotubes were exposed to IH-901 for up to 3 hours; and these effects including glucose uptake were attenuated by pretreatment with LY294002, a selective phosphatidylinositol-3 kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	228-236	thymoma viral proto-oncogene 1	Mus musculus	47-50
20309637-5	2011	Furthermore, MxA, 2",5"-OAS and PKR expression were down-regulated while PI3K-AKT signal pathway was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	MX dynamin like GTPase 1	Homo sapiens	13-16
20309637-5	2011	Furthermore, MxA, 2",5"-OAS and PKR expression were down-regulated while PI3K-AKT signal pathway was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	SPARC related modular calcium binding 1	Homo sapiens	24-27
20875857-8	2011	Co-treatment with the specific PI3K inhibitor LY294002 reversed the restoration of Akt activity and attenuation of hippocampal apoptosis, while it had no significant effect on these parameters on its own.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	83-86
20821260-6	2011	The presence of the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 and the mitogen-activated protein kinase kinases (MEK) inhibitor PD98059 blocked the effect of IGF-1 on BACE-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	20-49
20821260-6	2011	The presence of the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 and the mitogen-activated protein kinase kinases (MEK) inhibitor PD98059 blocked the effect of IGF-1 on BACE-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	insulin-like growth factor 1	Rattus norvegicus	172-177
20821260-6	2011	The presence of the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 and the mitogen-activated protein kinase kinases (MEK) inhibitor PD98059 blocked the effect of IGF-1 on BACE-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	beta-secretase 1	Rattus norvegicus	181-187
21109975-6	2011	With the combined application of LY294002 (specific inhibitor of AKT signaling) and IFN-gamma, tumor cell apoptosis was induced and the expression of TAP-1 and tapasin was still up-regulated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	150-155
21109975-6	2011	With the combined application of LY294002 (specific inhibitor of AKT signaling) and IFN-gamma, tumor cell apoptosis was induced and the expression of TAP-1 and tapasin was still up-regulated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	TAP binding protein	Homo sapiens	160-167
21430412-5	2011	Further studies showed that PI3K inhibition using LY294002 leads to a decrease in PI3K substrate Akt and mitogen-activated protein kinase extracellular signal-regulated kinase and p38 phosphorylation/activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	mitogen-activated protein kinase 14	Homo sapiens	180-183
22056597-8	2011	In high glucose-induced, insulin-resistant HepG2 cells, aromadendrin reversed the inhibition of Akt/PKB phosphorylation in response to insulin, which could be abrogated by pretreatment with LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	AKT serine/threonine kinase 1	Homo sapiens	100-103
22110694-8	2011	Protection from cell death was dependent on TNFR2 activation of the PI3K-PKB/Akt pathway, evident from restoration of H(2)O(2) sensitivity in the presence of PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	TNF receptor superfamily member 1B	Homo sapiens	44-49
22056597-8	2011	In high glucose-induced, insulin-resistant HepG2 cells, aromadendrin reversed the inhibition of Akt/PKB phosphorylation in response to insulin, which could be abrogated by pretreatment with LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	insulin	Homo sapiens	135-142
22056597-8	2011	In high glucose-induced, insulin-resistant HepG2 cells, aromadendrin reversed the inhibition of Akt/PKB phosphorylation in response to insulin, which could be abrogated by pretreatment with LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	insulin	Homo sapiens	25-32
22039465-13	2011	Blocking PI3K/Akt signaling with Ly294002 prevented wound-induced GSK3ss(Ser9) phosphorylation as well as ss-catenin nuclear translocation and significantly attenuated restitution.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
22028792-7	2011	Indeed, inhibition of Rho by C3 toxin and Akt by LY294002 blocked Sema4D-mediated endothelial cell migration and tubulogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	thymoma viral proto-oncogene 1	Mus musculus	42-45
22028792-7	2011	Indeed, inhibition of Rho by C3 toxin and Akt by LY294002 blocked Sema4D-mediated endothelial cell migration and tubulogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	Mus musculus	66-72
22046442-6	2011	By Western blotting, we found that combination treatment showed lower levels of phosphorylated Akt(Ser473) and GSK-3beta(Ser9) than a single treatment of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Homo sapiens	95-98
22046442-6	2011	By Western blotting, we found that combination treatment showed lower levels of phosphorylated Akt(Ser473) and GSK-3beta(Ser9) than a single treatment of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	glycogen synthase kinase 3 beta	Homo sapiens	111-125
22046442-4	2011	Activation of PI3K signaling pathway by IGF-1 protected U251 cells from apoptosis induced by combination treatment of LY294002 and tamoxifen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	insulin like growth factor 1	Homo sapiens	40-45
22046442-9	2011	Our results indicated that the synergistic cytotoxic effect of LY294002 and tamoxifen is achieved by the inhibition of GSK-3beta/beta-catenin signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	glycogen synthase kinase 3 beta	Homo sapiens	119-128
22046442-9	2011	Our results indicated that the synergistic cytotoxic effect of LY294002 and tamoxifen is achieved by the inhibition of GSK-3beta/beta-catenin signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	catenin beta 1	Homo sapiens	129-141
21984893-5	2011	Here we show that the pan-inhibitor of PI3Ks LY294002 is able to abrogate the TGF-beta-induced increase in cell proliferation, in alpha- smooth muscle actin expression and in collagen production besides inhibiting Akt phosphorylation, thus demonstrating the centrality of the PI3K/Akt pathway in lung fibroblast proliferation and differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	214-217
21980400-6	2011	Both PI3K inhibitor LY294002 and ERK inhibitor U0126 suppressed hypoxia-induced Rac1 activation as well as HIF-1alpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	Rac family small GTPase 1	Homo sapiens	80-84
21980400-6	2011	Both PI3K inhibitor LY294002 and ERK inhibitor U0126 suppressed hypoxia-induced Rac1 activation as well as HIF-1alpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
21984893-5	2011	Here we show that the pan-inhibitor of PI3Ks LY294002 is able to abrogate the TGF-beta-induced increase in cell proliferation, in alpha- smooth muscle actin expression and in collagen production besides inhibiting Akt phosphorylation, thus demonstrating the centrality of the PI3K/Akt pathway in lung fibroblast proliferation and differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	281-284
20926971-4	2010	Bromodeoxyuridine (BrdU) incorporation into the neurosphere cells induced by leptin was suppressed by LY294002, a PI3 K inhibitor, but not by U0126, a MEK1/2 inhibitor, which activates ERK1/2, although U0126 decreased phosphorylated extracellular signal regulated kinase levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	leptin	Homo sapiens	77-83
21909387-6	2011	In addition, Ly294002, a PI3K inhibitor, decreased the insulin effect on SPAK and NCC phosphorylation, indicating that insulin induces phosphorylation of SPAK and NCC through PI3K and WNK4 in mpkDCT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	insulin	Homo sapiens	55-62
21909387-6	2011	In addition, Ly294002, a PI3K inhibitor, decreased the insulin effect on SPAK and NCC phosphorylation, indicating that insulin induces phosphorylation of SPAK and NCC through PI3K and WNK4 in mpkDCT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	serine/threonine kinase 39	Homo sapiens	73-77
21909387-6	2011	In addition, Ly294002, a PI3K inhibitor, decreased the insulin effect on SPAK and NCC phosphorylation, indicating that insulin induces phosphorylation of SPAK and NCC through PI3K and WNK4 in mpkDCT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	insulin	Homo sapiens	119-126
21909387-6	2011	In addition, Ly294002, a PI3K inhibitor, decreased the insulin effect on SPAK and NCC phosphorylation, indicating that insulin induces phosphorylation of SPAK and NCC through PI3K and WNK4 in mpkDCT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	serine/threonine kinase 39	Homo sapiens	154-158
21909387-6	2011	In addition, Ly294002, a PI3K inhibitor, decreased the insulin effect on SPAK and NCC phosphorylation, indicating that insulin induces phosphorylation of SPAK and NCC through PI3K and WNK4 in mpkDCT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	WNK lysine deficient protein kinase 4	Homo sapiens	184-188
21738655-7	2011	Combination treatment of ERK pathway inhibitor PD98059 or AKT pathway inhibitor LY294002 and berberine could result in a synergistic reduction on MMP-9 expression along with an inhibition of cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	58-61
21738655-7	2011	Combination treatment of ERK pathway inhibitor PD98059 or AKT pathway inhibitor LY294002 and berberine could result in a synergistic reduction on MMP-9 expression along with an inhibition of cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	matrix metallopeptidase 9	Homo sapiens	146-151
19859713-10	2011	TNFalpha- or hypoxia-induced secretion of VEGF and IL-8 and expression of HIF-1alpha were hampered by treatment with the PI3 kinase inhibitor LY294002, suggesting that inhibition of PI3 kinase/Akt activation might inhibit VEGF and IL-8 secretion and HIF-1alpha expression induced by TNFalpha or hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	tumor necrosis factor	Homo sapiens	0-8
19859713-10	2011	TNFalpha- or hypoxia-induced secretion of VEGF and IL-8 and expression of HIF-1alpha were hampered by treatment with the PI3 kinase inhibitor LY294002, suggesting that inhibition of PI3 kinase/Akt activation might inhibit VEGF and IL-8 secretion and HIF-1alpha expression induced by TNFalpha or hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	vascular endothelial growth factor A	Homo sapiens	42-46
19859713-10	2011	TNFalpha- or hypoxia-induced secretion of VEGF and IL-8 and expression of HIF-1alpha were hampered by treatment with the PI3 kinase inhibitor LY294002, suggesting that inhibition of PI3 kinase/Akt activation might inhibit VEGF and IL-8 secretion and HIF-1alpha expression induced by TNFalpha or hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-84
19859713-10	2011	TNFalpha- or hypoxia-induced secretion of VEGF and IL-8 and expression of HIF-1alpha were hampered by treatment with the PI3 kinase inhibitor LY294002, suggesting that inhibition of PI3 kinase/Akt activation might inhibit VEGF and IL-8 secretion and HIF-1alpha expression induced by TNFalpha or hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	AKT serine/threonine kinase 1	Homo sapiens	193-196
19859713-10	2011	TNFalpha- or hypoxia-induced secretion of VEGF and IL-8 and expression of HIF-1alpha were hampered by treatment with the PI3 kinase inhibitor LY294002, suggesting that inhibition of PI3 kinase/Akt activation might inhibit VEGF and IL-8 secretion and HIF-1alpha expression induced by TNFalpha or hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	vascular endothelial growth factor A	Homo sapiens	222-226
19859713-10	2011	TNFalpha- or hypoxia-induced secretion of VEGF and IL-8 and expression of HIF-1alpha were hampered by treatment with the PI3 kinase inhibitor LY294002, suggesting that inhibition of PI3 kinase/Akt activation might inhibit VEGF and IL-8 secretion and HIF-1alpha expression induced by TNFalpha or hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	hypoxia inducible factor 1 subunit alpha	Homo sapiens	250-260
19859713-10	2011	TNFalpha- or hypoxia-induced secretion of VEGF and IL-8 and expression of HIF-1alpha were hampered by treatment with the PI3 kinase inhibitor LY294002, suggesting that inhibition of PI3 kinase/Akt activation might inhibit VEGF and IL-8 secretion and HIF-1alpha expression induced by TNFalpha or hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	tumor necrosis factor	Homo sapiens	283-291
21273759-0	2011	Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-29
21311135-7	2011	The protective effects of IGF-1 were attenuated in the presence of LY294002 but not PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	insulin-like growth factor 1	Rattus norvegicus	26-31
21311135-8	2011	The result of Western blot showed IGF-1 upregulated the expression of p-Akt, which was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	insulin-like growth factor 1	Rattus norvegicus	34-39
21311135-8	2011	The result of Western blot showed IGF-1 upregulated the expression of p-Akt, which was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
21625476-6	2011	Disruption of the PI3K/Akt pathway using the pharmacological inhibitor LY294002, siRNA targeting the p85 regulatory subunit of phosphatidylinositol-3 kinase, or by PTEN over-expression, partially restored TRAIL-mediated apoptosis in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Homo sapiens	23-26
21625476-7	2011	Moreover, the Akt inhibitor, LY294002, restituted normal cell proliferation index in HeLa cells expressing TRAIL-R4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	14-17
21625476-7	2011	Moreover, the Akt inhibitor, LY294002, restituted normal cell proliferation index in HeLa cells expressing TRAIL-R4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	TNF receptor superfamily member 10d	Homo sapiens	107-115
21597260-0	2011	Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-29
20926971-4	2010	Bromodeoxyuridine (BrdU) incorporation into the neurosphere cells induced by leptin was suppressed by LY294002, a PI3 K inhibitor, but not by U0126, a MEK1/2 inhibitor, which activates ERK1/2, although U0126 decreased phosphorylated extracellular signal regulated kinase levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	mitogen-activated protein kinase 1	Homo sapiens	233-270
21209852-7	2010	Furthermore, LPA increased PI3K activity, and the PI3K inhibitor LY294002 inhibited both LPA-induced PAK1/ERK activation and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	p21 (RAC1) activated kinase 1	Homo sapiens	101-105
21209852-7	2010	Furthermore, LPA increased PI3K activity, and the PI3K inhibitor LY294002 inhibited both LPA-induced PAK1/ERK activation and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	mitogen-activated protein kinase 1	Homo sapiens	106-109
20959443-6	2010	The MerTK (Mer receptor tyrosine kinase) and PI3K/Akt pathways played a key role in this immunomodulatory effect as shown using specific MerTK-blocking antibodies and PI3K inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	MER proto-oncogene, tyrosine kinase	Homo sapiens	4-9
20888802-5	2010	Downregulation impacted beta-catenin-mediated transcription, as LY294002 decreased beta-catenin/TCF transcriptional activity, determined by the reporter assay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	catenin beta 1	Homo sapiens	24-36
20888802-5	2010	Downregulation impacted beta-catenin-mediated transcription, as LY294002 decreased beta-catenin/TCF transcriptional activity, determined by the reporter assay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	catenin beta 1	Homo sapiens	83-95
20888802-5	2010	Downregulation impacted beta-catenin-mediated transcription, as LY294002 decreased beta-catenin/TCF transcriptional activity, determined by the reporter assay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	hepatocyte nuclear factor 4 alpha	Homo sapiens	96-99
20959443-6	2010	The MerTK (Mer receptor tyrosine kinase) and PI3K/Akt pathways played a key role in this immunomodulatory effect as shown using specific MerTK-blocking antibodies and PI3K inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	MER proto-oncogene, tyrosine kinase	Homo sapiens	11-39
20888802-6	2010	Similar results were observed in vivo, as intratumoral injection of LY294002 downregulated the expression of the components of the beta-catenin pathway and delayed tumor growth in nude mice harboring subcutaneous LN229 xenografts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	catenin (cadherin associated protein), beta 1	Mus musculus	131-143
20959443-6	2010	The MerTK (Mer receptor tyrosine kinase) and PI3K/Akt pathways played a key role in this immunomodulatory effect as shown using specific MerTK-blocking antibodies and PI3K inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	AKT serine/threonine kinase 1	Homo sapiens	50-53
21098227-5	2010	In this study, we demonstrate that the induction of TNF and IL-6 expression by LVS in mouse bone marrow-derived macrophages was markedly enhanced when PI3K activity was inhibited by either of the well-known chemical inhibitors, wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	tumor necrosis factor	Mus musculus	52-55
21215240-6	2010	A blocker of PI3K, LY294002, significantly attenuated H2O2 (10 muM, 24 hr) - induced cytoprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	latexin	Homo sapiens	63-66
21215240-7	2010	In addition, pretreatment with LY294002 reduced H2O2 (10 muM, 10 min)-induced phosphorylation of Akt at Ser473.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	latexin	Homo sapiens	57-60
21215240-7	2010	In addition, pretreatment with LY294002 reduced H2O2 (10 muM, 10 min)-induced phosphorylation of Akt at Ser473.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	97-100
21068409-5	2010	We also found that expression of miR-101 is induced by multiple TLR ligands, including LPS, peptidoglycan, or polyinosinic-polycytidylic acid, and that inhibition of PI3K/Akt by LY294002 or Akt RNA interference blocks the induction of miR-101 by LPS in RAW264.7 macrophage cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	microRNA 101a	Mus musculus	33-40
21068409-5	2010	We also found that expression of miR-101 is induced by multiple TLR ligands, including LPS, peptidoglycan, or polyinosinic-polycytidylic acid, and that inhibition of PI3K/Akt by LY294002 or Akt RNA interference blocks the induction of miR-101 by LPS in RAW264.7 macrophage cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	thymoma viral proto-oncogene 1	Mus musculus	171-174
20854808-9	2010	Meanwhile leonurine significantly increased Akt phosphorylation in a concentration-dependent manner in H9c2 cardiac myocyte induced by oxidative stress in vitro, which was abolished by a phosphoinositide 3-kinase (PI3K) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	231-239	AKT serine/threonine kinase 1	Rattus norvegicus	44-47
21098227-5	2010	In this study, we demonstrate that the induction of TNF and IL-6 expression by LVS in mouse bone marrow-derived macrophages was markedly enhanced when PI3K activity was inhibited by either of the well-known chemical inhibitors, wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	interleukin 6	Mus musculus	60-64
20850432-5	2010	This protective effect of HGF on CSE-induced apoptosis was abolished by PI3K inhibitors, wortmannin and LY294002, and by introduction of the dominant negative AKT into the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	hepatocyte growth factor	Homo sapiens	26-29
20654639-11	2010	Pretreating oocytes with wortmannin or LY294002, PI3K inhibitors, also significantly reduced EAAC1 activity, but no difference was observed between oocytes treated with wortmannin, corticosterone, or wortmannin plus corticosterone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	solute carrier family 1 member 1	Rattus norvegicus	93-98
21102479-9	2010	Interestingly, tanshione IIA significantly increased the phosphorylated Akt level, which was countered by the PI3K antagonist wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
20813109-7	2010	The SDF-1-mediated migration of the CST-expressing CPCs was attenuated by PI3 kinase inhibitor LY294002 but not by mitogen-activated protein/ERK kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	stromal cell-derived factor 1	Canis lupus familiaris	4-9
20813109-7	2010	The SDF-1-mediated migration of the CST-expressing CPCs was attenuated by PI3 kinase inhibitor LY294002 but not by mitogen-activated protein/ERK kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	clusterin	Canis lupus familiaris	36-39
20813109-7	2010	The SDF-1-mediated migration of the CST-expressing CPCs was attenuated by PI3 kinase inhibitor LY294002 but not by mitogen-activated protein/ERK kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	peptidase inhibitor 3	Canis lupus familiaris	74-77
20971737-8	2010	ErbB-2-enhanced matriptase activation was suppressed by a phosphatidylinositol 3-kinase inhibitor (ie, LY294002) but not by a MEK inhibitor (ie, PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-6
20698845-9	2010	In addition, TGF-beta enhanced MMP-2 production and activity, which could be abrogated by pretreatment with an AKT inhibitor (LY294002) but not with rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	transforming growth factor alpha	Homo sapiens	13-21
20870746-8	2010	Treatment with LY-294002, an inhibitor of the PI3-kinase pathway, prevented the SP-A-induced PM enrichment of P63.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	surfactant protein A1	Homo sapiens	80-84
20870746-8	2010	Treatment with LY-294002, an inhibitor of the PI3-kinase pathway, prevented the SP-A-induced PM enrichment of P63.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	cytoskeleton associated protein 4	Homo sapiens	110-113
20698845-9	2010	In addition, TGF-beta enhanced MMP-2 production and activity, which could be abrogated by pretreatment with an AKT inhibitor (LY294002) but not with rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	matrix metallopeptidase 2	Homo sapiens	31-36
20698845-9	2010	In addition, TGF-beta enhanced MMP-2 production and activity, which could be abrogated by pretreatment with an AKT inhibitor (LY294002) but not with rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	AKT serine/threonine kinase 1	Homo sapiens	111-114
21086135-7	2010	In addition, in cells induced to differentiate by ATRA or VD3, Nitroblue-tetrazolium (NBT) reduction and esterase activity, were blocked either by LY294002, a PI3K inhibitor, or by BIM, a PKC inhibitor, without affecting cell surface markers such as CD11b or CD14.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	protein kinase C alpha	Homo sapiens	188-191
20828639-7	2010	The PI3K and MEK/ERK pathway inhibitors Ly294002 and U0126 reduced RANKL expression levels in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	midkine	Mus musculus	13-16
20828639-7	2010	The PI3K and MEK/ERK pathway inhibitors Ly294002 and U0126 reduced RANKL expression levels in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	mitogen-activated protein kinase 1	Mus musculus	17-20
20828639-7	2010	The PI3K and MEK/ERK pathway inhibitors Ly294002 and U0126 reduced RANKL expression levels in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	67-72
22166638-15	2010	Furthermore, the cardioprotective effect limiting the infarct size that was induced by NRG-1 was abolished by co-administration of the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	neuregulin 1	Rattus norvegicus	87-92
20875851-8	2010	Furthermore, PNU282987 increased the expression of heme oxygenase-1 (HO-1), a critical cell defense enzyme against oxidative stress; this increase was prevented by AG490 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	heme oxygenase 1	Homo sapiens	51-67
20875851-8	2010	Furthermore, PNU282987 increased the expression of heme oxygenase-1 (HO-1), a critical cell defense enzyme against oxidative stress; this increase was prevented by AG490 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	heme oxygenase 1	Homo sapiens	69-73
20872216-4	2010	Inactivation of PI 3-kinase by the pharmacologic inhibitor Ly294002 or by dominant negative (DN) enzyme significantly blocked BMP-2-induced Osx protein and mRNA expression and Osx transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	bone morphogenetic protein 2	Homo sapiens	126-131
20872216-4	2010	Inactivation of PI 3-kinase by the pharmacologic inhibitor Ly294002 or by dominant negative (DN) enzyme significantly blocked BMP-2-induced Osx protein and mRNA expression and Osx transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	Sp7 transcription factor	Homo sapiens	140-143
20872216-4	2010	Inactivation of PI 3-kinase by the pharmacologic inhibitor Ly294002 or by dominant negative (DN) enzyme significantly blocked BMP-2-induced Osx protein and mRNA expression and Osx transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	Sp7 transcription factor	Homo sapiens	176-179
21098703-6	2010	Treatment of cells with the well-known PI3K inhibitor LY294002, and its structural analogue LY303511, which does not inhibit PI3K, increased homotypic GJIC; however, we found the effect to be independent of PI3K/AKT inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	212-215
21086135-7	2010	In addition, in cells induced to differentiate by ATRA or VD3, Nitroblue-tetrazolium (NBT) reduction and esterase activity, were blocked either by LY294002, a PI3K inhibitor, or by BIM, a PKC inhibitor, without affecting cell surface markers such as CD11b or CD14.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	integrin subunit alpha M	Homo sapiens	250-255
21086135-7	2010	In addition, in cells induced to differentiate by ATRA or VD3, Nitroblue-tetrazolium (NBT) reduction and esterase activity, were blocked either by LY294002, a PI3K inhibitor, or by BIM, a PKC inhibitor, without affecting cell surface markers such as CD11b or CD14.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	CD14 molecule	Homo sapiens	259-263
21042767-6	2010	In addition, we found that the protein level of p27Kip1 was up-regulated and the protein level of cyclin D1 was down-regulated following LY294002 treatment in those MM cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	cyclin dependent kinase inhibitor 1B	Homo sapiens	48-55
21119572-13	2010	Phosphatidyl inositol 3-kinase (PI3K) inhibitor, LY294002, extenuated the antiapoptotic effect of ghrelin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	ghrelin and obestatin prepropeptide	Rattus norvegicus	98-105
20869113-5	2010	The neuroprotective effects of TRH (10 muM) and RGH-2202 (10 muM) on St-induced cell death was attenuated by inhibitors of PI3-K pathway (wortmannin and LY294002), but not MAPK/ERK1/2 (PD98059 and U0126).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	thyrotropin releasing hormone	Homo sapiens	31-34
20869113-5	2010	The neuroprotective effects of TRH (10 muM) and RGH-2202 (10 muM) on St-induced cell death was attenuated by inhibitors of PI3-K pathway (wortmannin and LY294002), but not MAPK/ERK1/2 (PD98059 and U0126).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	latexin	Homo sapiens	61-64
20577844-8	2010	Addition of either IGF-1 receptor-blocking antibodies or LY294002 in order to inhibit phosphatidylinositol 3-kinase, a downstream effector of the IGF-1 receptor, inhibited the hypertrophic response indicating that IGF-1 signalling is required.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	insulin like growth factor 1	Homo sapiens	146-151
20577844-8	2010	Addition of either IGF-1 receptor-blocking antibodies or LY294002 in order to inhibit phosphatidylinositol 3-kinase, a downstream effector of the IGF-1 receptor, inhibited the hypertrophic response indicating that IGF-1 signalling is required.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	insulin like growth factor 1	Homo sapiens	146-151
20855443-6	2010	Blockage of ERK1/2 or AKT activation by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126; MKK1/2 inhibitor) or 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002; phosphatidyl inositol 3-kinase inhibitor), respectively, decreased the gemcitabine-induced Rad51 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-170	AKT serine/threonine kinase 1	Homo sapiens	22-25
20855443-6	2010	Blockage of ERK1/2 or AKT activation by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126; MKK1/2 inhibitor) or 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002; phosphatidyl inositol 3-kinase inhibitor), respectively, decreased the gemcitabine-induced Rad51 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	mitogen-activated protein kinase 3	Homo sapiens	12-18
20855443-6	2010	Blockage of ERK1/2 or AKT activation by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126; MKK1/2 inhibitor) or 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002; phosphatidyl inositol 3-kinase inhibitor), respectively, decreased the gemcitabine-induced Rad51 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	AKT serine/threonine kinase 1	Homo sapiens	22-25
20861085-5	2010	Interestingly, combination treatment with rapamycin and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, not only reduced the expression of NSC/progenitor markers more efficiently than single-agent treatment, but also increased the expression of betaIII-tubulin, a neuronal differentiation marker.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	68-97
21042767-6	2010	In addition, we found that the protein level of p27Kip1 was up-regulated and the protein level of cyclin D1 was down-regulated following LY294002 treatment in those MM cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	cyclin D1	Homo sapiens	98-107
21205476-2	2010	METHODS: PI3K inhibitor LY294002 and MEK inhibitor U0126 were used to block the PI3K/Akt and MEK/ERK pathways respectively, and constitutively activated Akt mutant construct was used to activate the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	85-88
20554189-10	2010	In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	cyclin B1	Homo sapiens	44-53
20554189-10	2010	In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	cyclin B1	Homo sapiens	44-53
20554189-10	2010	In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	H3 histone pseudogene 16	Homo sapiens	109-112
20554189-10	2010	In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	H3 histone pseudogene 16	Homo sapiens	150-153
21205476-5	2010	RESULTS: LY294002 not only blocked Akt activation efficiently but also increased ERK phosphorylation markedly under endoplasmic reticulum stress in SMMC-7721 and Hep3B cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	35-38
21205476-5	2010	RESULTS: LY294002 not only blocked Akt activation efficiently but also increased ERK phosphorylation markedly under endoplasmic reticulum stress in SMMC-7721 and Hep3B cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	mitogen-activated protein kinase 1	Homo sapiens	81-84
21055793-9	2010	Preincubation of platelets with the PI 3-kinase inhibitor, wortmannin or LY294002, impaired PAR1-AP-induced aggregation of platelets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	microtubule affinity regulating kinase 2	Homo sapiens	92-96
21215189-8	2010	And then, the effects of P38MAPK, PI-3K and ERK1/2 pathway inhibitors (SB203580, LY294002, U0126) and DMSO on CD59 and Crry expression were respectively detected by flow cytometry.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	CD59 molecule (CD59 blood group)	Homo sapiens	110-114
21348195-4	2010	The LY294002 groups were treated with the PI3K/AKT signaling pathway inhibitor LY294002 at 50 and 100 mg/kg every other day for 30 days.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	AKT serine/threonine kinase 1	Rattus norvegicus	47-50
21348195-4	2010	The LY294002 groups were treated with the PI3K/AKT signaling pathway inhibitor LY294002 at 50 and 100 mg/kg every other day for 30 days.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Rattus norvegicus	47-50
20399244-11	2010	Moreover, U0126 and LY294002, pharmacological inhibitors of MEK1/2 and phosphatidylinositol 3-kinase which are upstream of ERK1/2 and Akt/protein kinase B, respectively attenuated HO-1 and GCLC expression as well as the ARE-driven transcriptional activation of Nrf2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mitogen activated protein kinase kinase 1	Rattus norvegicus	60-66
20399244-11	2010	Moreover, U0126 and LY294002, pharmacological inhibitors of MEK1/2 and phosphatidylinositol 3-kinase which are upstream of ERK1/2 and Akt/protein kinase B, respectively attenuated HO-1 and GCLC expression as well as the ARE-driven transcriptional activation of Nrf2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mitogen activated protein kinase 3	Rattus norvegicus	123-129
20399244-11	2010	Moreover, U0126 and LY294002, pharmacological inhibitors of MEK1/2 and phosphatidylinositol 3-kinase which are upstream of ERK1/2 and Akt/protein kinase B, respectively attenuated HO-1 and GCLC expression as well as the ARE-driven transcriptional activation of Nrf2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Rattus norvegicus	134-137
20399244-11	2010	Moreover, U0126 and LY294002, pharmacological inhibitors of MEK1/2 and phosphatidylinositol 3-kinase which are upstream of ERK1/2 and Akt/protein kinase B, respectively attenuated HO-1 and GCLC expression as well as the ARE-driven transcriptional activation of Nrf2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	heme oxygenase 1	Rattus norvegicus	180-184
20399244-11	2010	Moreover, U0126 and LY294002, pharmacological inhibitors of MEK1/2 and phosphatidylinositol 3-kinase which are upstream of ERK1/2 and Akt/protein kinase B, respectively attenuated HO-1 and GCLC expression as well as the ARE-driven transcriptional activation of Nrf2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	189-193
20399244-11	2010	Moreover, U0126 and LY294002, pharmacological inhibitors of MEK1/2 and phosphatidylinositol 3-kinase which are upstream of ERK1/2 and Akt/protein kinase B, respectively attenuated HO-1 and GCLC expression as well as the ARE-driven transcriptional activation of Nrf2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	261-265
20876581-7	2010	We show that TGF-beta1 induced autophagy through TAK1 and Akt activation, and inhibition of PI3K-Akt pathway by LY294002 or dominant-negative Akt suppressed LC3 levels and enhanced caspase 3 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	thymoma viral proto-oncogene 1	Mus musculus	97-100
20876581-7	2010	We show that TGF-beta1 induced autophagy through TAK1 and Akt activation, and inhibition of PI3K-Akt pathway by LY294002 or dominant-negative Akt suppressed LC3 levels and enhanced caspase 3 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	thymoma viral proto-oncogene 1	Mus musculus	97-100
20876581-7	2010	We show that TGF-beta1 induced autophagy through TAK1 and Akt activation, and inhibition of PI3K-Akt pathway by LY294002 or dominant-negative Akt suppressed LC3 levels and enhanced caspase 3 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	157-160
20876581-7	2010	We show that TGF-beta1 induced autophagy through TAK1 and Akt activation, and inhibition of PI3K-Akt pathway by LY294002 or dominant-negative Akt suppressed LC3 levels and enhanced caspase 3 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	caspase 3	Mus musculus	181-190
21080918-11	2010	PC3 and LNCaP prostate cancer cells were also sensitive to treatment with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	chromobox 8	Homo sapiens	0-3
20826199-9	2010	More importantly, microinjection of PI3K inhibitor (LY294002) or mTOR inhibitor (Rapamycin) into the CA3 prevented the acquisition of CPP and inhibited the activation of PI3K-Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	carbonic anhydrase 3	Homo sapiens	101-104
20826199-9	2010	More importantly, microinjection of PI3K inhibitor (LY294002) or mTOR inhibitor (Rapamycin) into the CA3 prevented the acquisition of CPP and inhibited the activation of PI3K-Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	175-178
21080918-12	2010	However, the ErPC3-sensitive PC3-cells were less susceptible to LY294002 than the ErPC3-refractory LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	chromobox 8	Homo sapiens	15-18
21080918-14	2010	CONCLUSIONS: Our data suggest that constitutive Akt activation and survival are controlled by different different molecular mechanisms in the two prostate cancer cell lines - one which is sensitive to the Akt-inhibitor ErPC3 and one which is more sensitive to the PI3K-inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	279-287	AKT serine/threonine kinase 1	Homo sapiens	48-51
20512574-8	2010	Moreover, Tan I treatment remarkably downregulated the phosphorylation of both P85/PI3K and Akt in a time-dependent manner, and the PI3K/AKT-specific inhibitor (LY294002) mimicked the apoptosis-inducing effects of Tan I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	AKT serine/threonine kinase 1	Homo sapiens	92-95
20736003-6	2010	Inhibition of PI3K signaling also resulted in higher levels of the cyclin-dependent kinase inhibitors p21(Waf1/Cip1) and p27(Kip1); and knockdown of p27(kip1) with siRNA attenuated resistance to doxorubicin in cells treated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	zinc ribbon domain containing 2	Homo sapiens	149-152
20736003-6	2010	Inhibition of PI3K signaling also resulted in higher levels of the cyclin-dependent kinase inhibitors p21(Waf1/Cip1) and p27(Kip1); and knockdown of p27(kip1) with siRNA attenuated resistance to doxorubicin in cells treated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	cyclin dependent kinase inhibitor 1B	Homo sapiens	153-157
20890991-7	2010	Treatment with LY294002, a phosphatidylinositol-3-OH kinase (Pi3K) inhibitor, reduced the cathodal bias of protrusions in EFs and the frequency of changes in direction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	27-59
20974998-8	2010	The 3 HPIs and the phosphatidylinositol 3-kinase inhibitor LY294002 inhibited platelet-derived growth factor-induced phosphorylation of Akt and GSK3 in cultured pulmonary artery smooth muscle cells and blocked cell proliferation; this last effect was abolished by the GSK3 inhibitor SB216763.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Rattus norvegicus	136-139
20512574-8	2010	Moreover, Tan I treatment remarkably downregulated the phosphorylation of both P85/PI3K and Akt in a time-dependent manner, and the PI3K/AKT-specific inhibitor (LY294002) mimicked the apoptosis-inducing effects of Tan I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	AKT serine/threonine kinase 1	Homo sapiens	137-140
20544350-10	2010	Pharmacological inhibition of Akt by LY294002 restored sensitivity of activated B-CLL cells to fludarabine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	30-33
20705918-7	2010	Treatment with LY294002 or Akt short interfering RNA decreased the eNOS activation, SIRT1 expression, and antisenescent property of atorvastatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	sirtuin 1	Mus musculus	84-89
20495838-12	2010	LY294002 (a PI3-K inhibitor) blocked apelin-induced activation of Akt and abolished the apelin-induced antiapoptotic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	apelin	Homo sapiens	37-43
20495838-12	2010	LY294002 (a PI3-K inhibitor) blocked apelin-induced activation of Akt and abolished the apelin-induced antiapoptotic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	66-69
20495838-12	2010	LY294002 (a PI3-K inhibitor) blocked apelin-induced activation of Akt and abolished the apelin-induced antiapoptotic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	apelin	Homo sapiens	88-94
20877127-8	2010	The PI3K inhibitor, LY294002, prevented the phosphorylation of Akt, decreased the recovery of ATP and restoration of sarcolemmal dystrophin, and blocked the anti-oncotic and anti-apoptotic effects of IPost.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Rattus norvegicus	63-66
20947290-4	2010	Our work demonstrates that blocking PI3K/Akt by LY294002 inhibits the NF-kappaB activity with significantly increased apoptosis in gastric cancer cell.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	41-44
20947290-4	2010	Our work demonstrates that blocking PI3K/Akt by LY294002 inhibits the NF-kappaB activity with significantly increased apoptosis in gastric cancer cell.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	nuclear factor kappa B subunit 1	Homo sapiens	70-79
20599609-7	2010	The classical and novel protein kinase C (PKC) antagonist calphostin C, as well as phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, abolished NMU responses, whereas the classical PKC antagonist Go6976 had no such effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	neuromedin U	Mus musculus	150-153
20980837-6	2010	Blocking PI3K with LY294002 inhibits LrECM-dependent Rac1 activation, attenuates sustained STAT5 phosphorylation and blocks beta-casein gene transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	Rac family small GTPase 1	Homo sapiens	53-57
20980837-6	2010	Blocking PI3K with LY294002 inhibits LrECM-dependent Rac1 activation, attenuates sustained STAT5 phosphorylation and blocks beta-casein gene transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	signal transducer and activator of transcription 5A	Homo sapiens	91-96
20877127-8	2010	The PI3K inhibitor, LY294002, prevented the phosphorylation of Akt, decreased the recovery of ATP and restoration of sarcolemmal dystrophin, and blocked the anti-oncotic and anti-apoptotic effects of IPost.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	dystrophin	Rattus norvegicus	129-139
20198432-13	2010	Compared with genistein group, Western blots also demonstrated decreased Akt phosphorylation in LY294002 group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	AKT serine/threonine kinase 1	Rattus norvegicus	73-76
21776468-7	2010	Wortmannin and LY294002, inhibitors for phosphatidylinositol 3"-kinase (PI3K), decreased EC- and EGC-induced glucose uptake activity in the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	40-70
20696207-8	2010	Caspases were inhibited with zVAD-FMK and zDEVD-FMK; autophagy with 3-methyladenine, LY294002, and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	caspase 8	Homo sapiens	0-8
20499340-11	2010	PI3-kinase (PI3K) inhibitor LY294002 abolishes the IGF-2 potentiation effect on BMP-9-mediated osteogenic signaling and can directly inhibit BMP-9 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-10
20574012-9	2010	The poly(I:C)-induced expression of VCAM-1 and ICAM-1 was attenuated by both IKK2 inhibitor and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	vascular cell adhesion molecule 1	Homo sapiens	36-42
20574012-9	2010	The poly(I:C)-induced expression of VCAM-1 and ICAM-1 was attenuated by both IKK2 inhibitor and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	intercellular adhesion molecule 1	Homo sapiens	47-53
20506505-7	2010	Inhibitors of PI3K (LY294002 and Wortmannin) prevented the phosphorylation of ERK1/2, p38 MAPK, and Akt PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mitogen-activated protein kinase 3	Homo sapiens	78-84
20539001-13	2010	IGF-1 also increased whole-cell current with a corresponding increase in [Ca(2+)](i), which was blocked by the PI3-kinase blocker LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	insulin like growth factor 1	Homo sapiens	0-5
20204404-8	2010	LY294002 treatment was able to recruit E-cadherin, beta-catenin, claudin-3, and ZO-1 to the cell-cell contact region, and this effect was essential for AJC assembly and association of these proteins to the cytoskeleton.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cadherin 1	Homo sapiens	39-49
20204404-8	2010	LY294002 treatment was able to recruit E-cadherin, beta-catenin, claudin-3, and ZO-1 to the cell-cell contact region, and this effect was essential for AJC assembly and association of these proteins to the cytoskeleton.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	catenin beta 1	Homo sapiens	51-63
20506505-7	2010	Inhibitors of PI3K (LY294002 and Wortmannin) prevented the phosphorylation of ERK1/2, p38 MAPK, and Akt PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	100-103
20499340-11	2010	PI3-kinase (PI3K) inhibitor LY294002 abolishes the IGF-2 potentiation effect on BMP-9-mediated osteogenic signaling and can directly inhibit BMP-9 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	insulin like growth factor 2	Homo sapiens	51-56
20204404-8	2010	LY294002 treatment was able to recruit E-cadherin, beta-catenin, claudin-3, and ZO-1 to the cell-cell contact region, and this effect was essential for AJC assembly and association of these proteins to the cytoskeleton.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	claudin 3	Homo sapiens	65-74
20499340-11	2010	PI3-kinase (PI3K) inhibitor LY294002 abolishes the IGF-2 potentiation effect on BMP-9-mediated osteogenic signaling and can directly inhibit BMP-9 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	growth differentiation factor 2	Homo sapiens	80-85
20499340-11	2010	PI3-kinase (PI3K) inhibitor LY294002 abolishes the IGF-2 potentiation effect on BMP-9-mediated osteogenic signaling and can directly inhibit BMP-9 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	growth differentiation factor 2	Homo sapiens	141-146
20956467-13	2010	Immunoblots displayed rapid phosphorylation of PI3K and Akt within minutes of E(2) treatment, and the specific PI3K inhibitors wortmannin and LY294002 abolished the ability of E(2) to elevate (18)F-FDG uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	AKT serine/threonine kinase 1	Homo sapiens	56-59
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	243-251	AKT serine/threonine kinase 1	Homo sapiens	6-9
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	243-251	AKT serine/threonine kinase 1	Homo sapiens	100-103
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	243-251	AKT serine/threonine kinase 1	Homo sapiens	100-103
20836715-5	2010	Since Akt is a critical downstream regulator of PI3K, we investigated the phosphorylation status of Akt in M-SMCs after treatment with poly I:C for 1 h and found that Akt was phosphorylated, but the phosphorylated Akt band was undetectable in LY294002 plus poly I:C-treated cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	243-251	AKT serine/threonine kinase 1	Homo sapiens	100-103
20665543-8	2010	Furthermore, we demonstrated that phosphorylation of Akt was elevated by LPS treatment and reduced by TLR2 blockers, TLR4 blockers, and LY294002 (PI(3)K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	AKT serine/threonine kinase 1	Rattus norvegicus	53-56
21126656-7	2010	LBT-induced MMP-2 secretion was not inhibited by PD98059 (up to 50 muM) when ERK was effectively blocked, but was attenuated by LY294002 (0-10 muM) in a concentration-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	matrix metallopeptidase 2	Homo sapiens	12-17
20956467-13	2010	Immunoblots displayed rapid phosphorylation of PI3K and Akt within minutes of E(2) treatment, and the specific PI3K inhibitors wortmannin and LY294002 abolished the ability of E(2) to elevate (18)F-FDG uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	cystatin 12, pseudogene	Homo sapiens	78-82
20956467-13	2010	Immunoblots displayed rapid phosphorylation of PI3K and Akt within minutes of E(2) treatment, and the specific PI3K inhibitors wortmannin and LY294002 abolished the ability of E(2) to elevate (18)F-FDG uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	cystatin 12, pseudogene	Homo sapiens	176-180
20694540-7	2010	The VIP-induced vasorelaxation was markedly reduced by the inhibition of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway with wortmannin and LY294002, respectively, which was seen in EI rings, but not in ED rings.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	vasoactive intestinal peptide	Rattus norvegicus	4-7
20694540-7	2010	The VIP-induced vasorelaxation was markedly reduced by the inhibition of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway with wortmannin and LY294002, respectively, which was seen in EI rings, but not in ED rings.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	AKT serine/threonine kinase 1	Rattus norvegicus	130-133
21138632-12	2010	The HCCR-2 protein was up-regulated in a dose-dependent manner in the cells cultured with different concentrations of EGF for 24 h. Treatment of SMMC 7721 cells with specific inhibitor of PI3K (LY294002) suppressed EGF-induced HCCR-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	LETM1 domain containing 1	Homo sapiens	4-10
21040406-0	2010	Sulfatase 2 protects hepatocellular carcinoma cells against apoptosis induced by the PI3K inhibitor LY294002 and ERK and JNK kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	sulfatase 2	Homo sapiens	0-11
21040406-5	2010	Treatment with inhibitors of MEK, JNK and PI3 kinases decreased the viability of SULF2-negative Hep3B HCC cells and induced apoptotic caspase 3 and 7 activity, which was most strongly induced by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	mitogen-activated protein kinase 8	Homo sapiens	34-37
21040406-6	2010	Forced expression of SULF2 in Hep3B cells significantly decreased activity of the apoptotic caspases 3 and 7 and induced resistance to LY294002-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	sulfatase 2	Homo sapiens	21-26
21040406-7	2010	As expected, LY294002 inhibited activation of Akt kinase by PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	46-49
20658310-8	2010	Further, treatment with PI3K inhibitor (LY294002) and quercetin showed decreased p-Akt levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	83-86
21138632-12	2010	The HCCR-2 protein was up-regulated in a dose-dependent manner in the cells cultured with different concentrations of EGF for 24 h. Treatment of SMMC 7721 cells with specific inhibitor of PI3K (LY294002) suppressed EGF-induced HCCR-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	LETM1 domain containing 1	Homo sapiens	227-233
20554973-4	2010	In contrast, LY294002 (a PI3K inhibitor) prevented the aggregation of PTEN(+/+), but not PTEN(-/-), platelets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	phosphatase and tensin homolog	Mus musculus	70-74
20869949-8	2010	Contrarily, blockade of HIF-1alpha by siRNA and inhibition of Akt by either wortmannin or LY294002 abrogated upregulation of HP-induced CXCR4 and CXCR7 in MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 1	Homo sapiens	62-65
20869949-8	2010	Contrarily, blockade of HIF-1alpha by siRNA and inhibition of Akt by either wortmannin or LY294002 abrogated upregulation of HP-induced CXCR4 and CXCR7 in MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	C-X-C motif chemokine receptor 4	Homo sapiens	136-141
20705061-10	2010	Meanwhile, we found that thalidomide induced p-Akt expression, which could be inhibited by PI3K specific inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Rattus norvegicus	47-50
20661217-7	2010	Although the fact that TRAIL-induced caspase-8 activation was observed in both sensitive and resistant cell lines, Bid cleavage occurred only in sensitive cells or in SKOV3ip1 cells treated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	TNF superfamily member 10	Homo sapiens	23-28
20661217-7	2010	Although the fact that TRAIL-induced caspase-8 activation was observed in both sensitive and resistant cell lines, Bid cleavage occurred only in sensitive cells or in SKOV3ip1 cells treated with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	BH3 interacting domain death agonist	Homo sapiens	115-118
20224070-7	2010	Corticosteroid insensitivity and reduced histone deacetylase-2 activity after oxidative stress were reversed by a non-selective PI3K inhibitor (LY294002) and low concentrations of theophylline.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	histone deacetylase 2	Homo sapiens	41-62
20596034-7	2010	The likelihood of such a mechanism of action is further strengthened by the fact that inhibition of phosphoinositide 3-kinase with wortmannin or LY 294002, and Akt inhibition, were shown to lead to a decrease in P-AKT and to a consequent increase in Mn-SOD mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-154	superoxide dismutase 2	Rattus norvegicus	250-256
20542106-9	2010	An increase in cyclin D1 expression, that could be inhibited by 10 microM LY 294002 or 20 microM U0126, was observed when cells were incubated with 500 microM ADP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-83	cyclin D1	Gallus gallus	15-24
20639353-8	2010	Finally, we found that activation of equine neutrophils with IL-4 involved STAT6 phosphorylation and p38 MAPK and phosphatidylinositol 3-kinase (PI3K); the pharmacological inhibitors, SB-203580 and LY-294002, respectively, significantly reversed IL-4-induced gene modulation in PBN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	198-207	interleukin 4	Equus caballus	61-65
20580365-6	2010	Migration induced by LTB4 was inhibited in the presence of pertussis toxin, CP-105696, a BLT1 receptor antagonist, and by LY294002 or PD98059, two inhibitors of PI3K and MEK1/2, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	mitogen activated protein kinase kinase 1	Rattus norvegicus	170-176
20813965-8	2010	SOGA decreased in response to AICAR, an activator of AMPK, and LY294002, an inhibitor of the insulin signaling intermediate, PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	suppressor of glucose, autophagy associated 1	Homo sapiens	0-4
20813965-8	2010	SOGA decreased in response to AICAR, an activator of AMPK, and LY294002, an inhibitor of the insulin signaling intermediate, PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	insulin	Homo sapiens	93-100
20876744-7	2010	Activators of mTOR increased SCD1 protein expression, whereas rapamycin, LY294002, and BEZ235 decreased SCD1 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	stearoyl-CoA desaturase	Homo sapiens	104-108
20458733-5	2010	Moreover, Ang II could significantly accelerate S-phase progression, which was inhibited by losartan (10(-5) M) or LY294002 (50 microM, a PI3-kinase inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	angiotensinogen	Homo sapiens	10-16
20458733-9	2010	Pretreatment with losartan (10(-5) M) or LY294002 (50 microM) could significantly suppress these effects of Ang II.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	angiotensinogen	Homo sapiens	108-114
20503249-5	2010	The SAA cytotoxicity was blocked by co-incubation with catalase, whereas the SBA cytotoxicity and its subsequent growth arrest were abolished by N-acetyl-L-cysteine (NAC), but was not affected by PI3K phosphorylation inhibitor LY294002, or catalase, suggesting two separated oxidative stress pathways were mediated by these two ascorbates.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	227-235	X-linked Kx blood group	Homo sapiens	166-169
20876358-3	2010	This activation was largely suppressed by mutation of the Walker A lysines in the nucleotide-binding domains of SUR1: the remaining small (~10%), slowly developing component of MgATP activation was fully inhibited by the lipid kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	244-252	ATP binding cassette subfamily C member 8	Homo sapiens	112-116
20885962-3	2010	During normal adipogenic induction as well as adipogenic inhibition by Ly294002, we confirmed that the intensity of green fluorescence protein corresponded well to the expression level of aP2 gene.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	fatty acid binding protein 4	Homo sapiens	188-191
20638445-5	2010	A phosphatidylinositol 3 kinase (PI3 kinase) inhibitor (LY294002) blocked attachment of neurosphere, astrocytic differentiation, migration, and N-cadherin upregulation of neurosphre NSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	cadherin 2	Homo sapiens	144-154
20875097-8	2010	The bradykinin effect on resensitization was similar in the absence of extracellular Ca2+ or in the presence of the PKC activator PMA, but was inhibited by the protein phosphatase inhibitor okadaic acid and the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	226-234	kininogen 1	Homo sapiens	4-14
20558128-8	2010	In addition, piceatannol-induced activation of Nrf2 and/or HO-1 expression was abrogated by the pharmacological inhibitor (LY294002) as well as the kinase-dead form of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
20367258-6	2010	Pharmacological inhibitors directed toward PI3K (wortmannin and LY294002), or the mito-K(ATP) channel (glybenclamide) inhibited the H(2)O(2)-mediated increase in ATP in cells overexpressing human Ngb and consequently cell viability decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	neuroglobin	Homo sapiens	196-199
20633529-9	2010	Last, inhibition of PI3-kinase activity with LY 294002 or wortmannin blocked AP-ICAM GSH induction and ROS production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-54	peptidase inhibitor 3	Homo sapiens	20-23
20633628-6	2010	This process increased the protein expressions of phosphorylated Akt, and an inhibitor of phosphatidylinositol 3-kinase (PI3K)/Akt, LY294002, significantly decreased this protective effect of Yi-Gan San.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	90-119
20633628-6	2010	This process increased the protein expressions of phosphorylated Akt, and an inhibitor of phosphatidylinositol 3-kinase (PI3K)/Akt, LY294002, significantly decreased this protective effect of Yi-Gan San.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	AKT serine/threonine kinase 1	Homo sapiens	127-130
20836878-9	2010	The use of PI3K inhibitor LY294002 or Akt siRNA abrogated the t-DARPP-mediated phosphorylation of AKT(ser473) and led to a significant reduction in cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	98-101
20836895-8	2010	LY294002 blocked TNF-alpha-induced phosphorylation of Akt and reduced the phosphorylation of both IkappaB-alpha and NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Rattus norvegicus	17-26
20836895-8	2010	LY294002 blocked TNF-alpha-induced phosphorylation of Akt and reduced the phosphorylation of both IkappaB-alpha and NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
20836895-8	2010	LY294002 blocked TNF-alpha-induced phosphorylation of Akt and reduced the phosphorylation of both IkappaB-alpha and NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	NFKB inhibitor alpha	Rattus norvegicus	98-111
20558128-8	2010	In addition, piceatannol-induced activation of Nrf2 and/or HO-1 expression was abrogated by the pharmacological inhibitor (LY294002) as well as the kinase-dead form of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	heme oxygenase 1	Homo sapiens	59-63
20506537-3	2010	In present study, we found that DNMT3B mRNA and protein levels were decreased in a dose- and time-dependent manner in HCC cell lines with LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	DNA methyltransferase 3 beta	Homo sapiens	32-38
20336745-4	2010	Coating with collagen I induced activation of ERK and Akt but not FAK, and treatment with PD98059 and LY294002 blocked the activation of ERK and Akt, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	mitogen-activated protein kinase 1	Homo sapiens	137-140
20336745-4	2010	Coating with collagen I induced activation of ERK and Akt but not FAK, and treatment with PD98059 and LY294002 blocked the activation of ERK and Akt, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	AKT serine/threonine kinase 1	Homo sapiens	145-148
20336745-5	2010	Interestingly, LY294002 also blocked ERK activation, indicating the activation of PI3K/ERK pathway upon contact with collagen I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mitogen-activated protein kinase 1	Homo sapiens	37-40
20336745-5	2010	Interestingly, LY294002 also blocked ERK activation, indicating the activation of PI3K/ERK pathway upon contact with collagen I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mitogen-activated protein kinase 1	Homo sapiens	87-90
20506537-7	2010	And DNMT3B mRNA decay analysis suggested that down-regulation of DNMT3B by LY294002 is also post-transcriptional control.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	DNA methyltransferase 3 beta	Homo sapiens	4-10
20506537-7	2010	And DNMT3B mRNA decay analysis suggested that down-regulation of DNMT3B by LY294002 is also post-transcriptional control.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	DNA methyltransferase 3 beta	Homo sapiens	65-71
20506537-8	2010	Furthermore, we demonstrated that LY294002 down-regulated HuR expression in a time-dependent manner in BEL-7404.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	ELAV like RNA binding protein 1	Homo sapiens	58-61
19653139-6	2010	hnRNPK expression levels in K562 cell line and imatinib-resistant leukemic cell line K562R, following the treatments with the inhibitors of Ras-MAPK (PD98059), PI3K/AKT (LY294002), JAK/STAT (AG490) signaling pathways, and BCR-ABL [imatinib mesylate (IM)], were also determined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	0-6
20629536-4	2010	Treating Z12 cells with either the PI3 kinase inhibitor LY294002 or the p38 MAPK inhibitor SB203580 significantly inhibited both the phosphorylation of CREB and expression of TGFbeta2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	cAMP responsive element binding protein 1	Homo sapiens	152-156
20629536-4	2010	Treating Z12 cells with either the PI3 kinase inhibitor LY294002 or the p38 MAPK inhibitor SB203580 significantly inhibited both the phosphorylation of CREB and expression of TGFbeta2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	transforming growth factor beta 2	Homo sapiens	175-183
20536682-9	2010	The neuroprotective effect was prevented by chelerythrine, LY294002, and Sn (IV) protoporphyrin IX dichloride (SnPP), indicating the participation of the PKC/PI3K/Akt activation and induction of the antioxidant enzyme heme oxygenase-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	163-166
20536682-9	2010	The neuroprotective effect was prevented by chelerythrine, LY294002, and Sn (IV) protoporphyrin IX dichloride (SnPP), indicating the participation of the PKC/PI3K/Akt activation and induction of the antioxidant enzyme heme oxygenase-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	heme oxygenase 1	Homo sapiens	218-234
20664988-4	2010	When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a &gt;60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	14-17
20229527-8	2010	LY294002, a specific inhibitor of phosphoinositide-3-kinase, suppressed Akt and IFN-gamma mRNA expression up-regulated by LPS, whereas PEITC exhibited a similar inhibition profile.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	72-75
20229527-8	2010	LY294002, a specific inhibitor of phosphoinositide-3-kinase, suppressed Akt and IFN-gamma mRNA expression up-regulated by LPS, whereas PEITC exhibited a similar inhibition profile.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interferon gamma	Mus musculus	80-89
20664988-4	2010	When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a &gt;60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	AKT serine/threonine kinase 1	Homo sapiens	14-17
20664988-4	2010	When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a &gt;60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	phosphatase and tensin homolog	Homo sapiens	153-157
20664988-4	2010	When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a &gt;60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	mitogen-activated protein kinase kinase 7	Homo sapiens	55-58
20664988-4	2010	When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a &gt;60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	phosphatase and tensin homolog	Homo sapiens	238-242
20664988-4	2010	When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a &gt;60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	mitogen-activated protein kinase 1	Homo sapiens	59-62
20664988-4	2010	When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a &gt;60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	phosphatase and tensin homolog	Homo sapiens	153-157
20664988-4	2010	When the PI3K/Akt signaling inhibitor LY294002 and the MEK/Erk signaling inhibitor U0126 were applied, LY294002 reduced cell proliferation in MDA-MB-468 PTEN and MDA-MB-468 vec by 20%, while U0126 led to a &gt;60% reduction in MDA-MB-468 PTEN and a 20% reduction in MDA-MB-468 vec cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	phosphatase and tensin homolog	Homo sapiens	238-242
20679550-7	2010	All of these effects were diminished by LY294002, an inhibitor of phosphatidylinositol 3-kinase; enhanced by deferoxamine, an HIF-1 alpha stabilizer; and impaired by knockout of MMP-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	matrix metallopeptidase 2	Mus musculus	178-183
20600219-10	2010	The protein kinase inhibitors had minimal or no effects on Ni/MALP-2-induced accumulation of HIF-1alpha protein, however, COX-2 expression and, more markedly PGE(2) production, were suppressed by LY294002, SB203580, and U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
20667453-3	2010	Insulin also significantly increased activating transcription factor-4 (ATF4) protein in the nucleus, which was inhibited by LY294002, a phosphatidylinositol 3-kinase (PI-3 kinase) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	insulin	Homo sapiens	0-7
20667453-3	2010	Insulin also significantly increased activating transcription factor-4 (ATF4) protein in the nucleus, which was inhibited by LY294002, a phosphatidylinositol 3-kinase (PI-3 kinase) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	activating transcription factor 4	Homo sapiens	37-70
20667453-3	2010	Insulin also significantly increased activating transcription factor-4 (ATF4) protein in the nucleus, which was inhibited by LY294002, a phosphatidylinositol 3-kinase (PI-3 kinase) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	activating transcription factor 4	Homo sapiens	72-76
21137347-7	2010	Pretreated with PD98059 and LY294002, cell proliferation induced by phosphatidic acid (PA) was inhibited, and the mRNA expression of mTOR, Raptor and Rictor was significantly decreased by CAR in the mimic IR medium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	mechanistic target of rapamycin kinase	Homo sapiens	133-137
21137347-7	2010	Pretreated with PD98059 and LY294002, cell proliferation induced by phosphatidic acid (PA) was inhibited, and the mRNA expression of mTOR, Raptor and Rictor was significantly decreased by CAR in the mimic IR medium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	regulatory associated protein of MTOR complex 1	Homo sapiens	139-145
21137347-7	2010	Pretreated with PD98059 and LY294002, cell proliferation induced by phosphatidic acid (PA) was inhibited, and the mRNA expression of mTOR, Raptor and Rictor was significantly decreased by CAR in the mimic IR medium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	RPTOR independent companion of MTOR complex 2	Homo sapiens	150-156
20623542-6	2010	LY294002 and amyloid peptide, known activators of GSK-3beta signaling, reduced delta-catenin expression levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	50-59
20678486-5	2010	However, mock-transfected cells, and Tensin2 cells harbouring a putative phosphatase-inactivating mutation, exhibited significant PtdIns(3,4,5)P(3) levels, which decreased upon phosphatidylinositol 3-kinase inhibition with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	223-231	tensin 2	Homo sapiens	37-44
20712893-11	2010	Although each TGF-beta isoform decreased PTEN content in a XIAP- and a Smad-dependent manner, decrease of PTEN levels in response to only one isoform, TGF-beta3, was blocked by PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	transforming growth factor beta 1	Homo sapiens	14-22
20712893-11	2010	Although each TGF-beta isoform decreased PTEN content in a XIAP- and a Smad-dependent manner, decrease of PTEN levels in response to only one isoform, TGF-beta3, was blocked by PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	phosphatase and tensin homolog	Homo sapiens	41-45
20712893-11	2010	Although each TGF-beta isoform decreased PTEN content in a XIAP- and a Smad-dependent manner, decrease of PTEN levels in response to only one isoform, TGF-beta3, was blocked by PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	phosphatase and tensin homolog	Homo sapiens	106-110
20712893-11	2010	Although each TGF-beta isoform decreased PTEN content in a XIAP- and a Smad-dependent manner, decrease of PTEN levels in response to only one isoform, TGF-beta3, was blocked by PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	transforming growth factor beta 3	Homo sapiens	151-160
20704765-0	2010	LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	73-76
20561929-7	2010	As well, JP05 blocked the inhibition of PI3K/Akt and ERK activities by LY294002 (PI3K/Akt inhibitor) and PD98059 (mitogen-activated protein kinase inhibitor), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	thymoma viral proto-oncogene 1	Mus musculus	45-48
20561929-7	2010	As well, JP05 blocked the inhibition of PI3K/Akt and ERK activities by LY294002 (PI3K/Akt inhibitor) and PD98059 (mitogen-activated protein kinase inhibitor), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	mitogen-activated protein kinase 1	Mus musculus	53-56
20561929-7	2010	As well, JP05 blocked the inhibition of PI3K/Akt and ERK activities by LY294002 (PI3K/Akt inhibitor) and PD98059 (mitogen-activated protein kinase inhibitor), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	thymoma viral proto-oncogene 1	Mus musculus	86-89
20651836-8	2010	Our results showed that recombinant human NRG-1(3.0 ng.kg-1) significantly increased the expression of p-Akt protein, Bcl-2 mRNA, and the level of p-Bad, respectively, whereas administration of LY294002, a specific inhibitor of PI3K, significantly decreased the expression of p-Akt, p-Bad, and Bcl-2 induced by NRG-1 after a 60 min ischemic insult, followed by 24 h of reperfusion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	neuregulin 1	Homo sapiens	42-47
20473571-6	2010	The activation was reproduced upon C5a-C5aR interaction by a simultaneous suppression of PI3K and phospholipase C with LY294002 and U73122 at low concentrations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	complement C5a receptor 1	Homo sapiens	35-38
20473571-6	2010	The activation was reproduced upon C5a-C5aR interaction by a simultaneous suppression of PI3K and phospholipase C with LY294002 and U73122 at low concentrations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	complement C5a receptor 1	Homo sapiens	39-43
20553273-7	2010	By using MEK1/2 inhibitor U0126, PI3K inhibitor LY294002, and STAT3 or STAT5 siRNAs, JAK2 V617F was found to specifically use the STAT3 pathway to enhance LAP expression, while STAT5, Ras/MEK/ERK and PI3K/Akt, but not STAT3 pathways, were able to stimulate cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	Janus kinase 2	Homo sapiens	85-89
20649564-11	2010	IL-1beta-stimulated activation and translocation of Akt and NF-kappaB (p65); the recruitment of activated NF-kappaB (p65) to the MMP-9 promoter region was attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	interleukin 1 beta	Homo sapiens	0-8
20649564-11	2010	IL-1beta-stimulated activation and translocation of Akt and NF-kappaB (p65); the recruitment of activated NF-kappaB (p65) to the MMP-9 promoter region was attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Homo sapiens	52-55
20649564-11	2010	IL-1beta-stimulated activation and translocation of Akt and NF-kappaB (p65); the recruitment of activated NF-kappaB (p65) to the MMP-9 promoter region was attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	nuclear factor kappa B subunit 1	Homo sapiens	60-69
20432459-6	2010	The activation of SSH-1 by Sorafenib is probably regulated by the PI3K pathway, since Sorafenib can induce PI3K and its substrate Akt phosphorylation, and both PI3K inhibitors Ly294002 and wortmannin antagonized Sorafenib-mediated cofilin dephosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	slingshot protein phosphatase 1	Homo sapiens	18-23
20649564-11	2010	IL-1beta-stimulated activation and translocation of Akt and NF-kappaB (p65); the recruitment of activated NF-kappaB (p65) to the MMP-9 promoter region was attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	RELA proto-oncogene, NF-kB subunit	Homo sapiens	71-74
20649564-11	2010	IL-1beta-stimulated activation and translocation of Akt and NF-kappaB (p65); the recruitment of activated NF-kappaB (p65) to the MMP-9 promoter region was attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	nuclear factor kappa B subunit 1	Homo sapiens	106-115
20649564-11	2010	IL-1beta-stimulated activation and translocation of Akt and NF-kappaB (p65); the recruitment of activated NF-kappaB (p65) to the MMP-9 promoter region was attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	RELA proto-oncogene, NF-kB subunit	Homo sapiens	117-120
20649564-11	2010	IL-1beta-stimulated activation and translocation of Akt and NF-kappaB (p65); the recruitment of activated NF-kappaB (p65) to the MMP-9 promoter region was attenuated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	matrix metallopeptidase 9	Homo sapiens	129-134
20370577-7	2010	Rapamycin and LY294002 induce a decline in Sp1 nuclear abundance and IGFBP-2 mRNA and protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	insulin like growth factor binding protein 2	Homo sapiens	69-76
20370578-4	2010	Inhibition of FGF receptors or of MEK1/2 and PI3K with specific inhibitors (PD173074, U0126 or LY294002, respectively) restored TSP-1 mRNA expression in the presence of FGF-8 in S115 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	mitogen-activated protein kinase kinase 1	Homo sapiens	34-40
20370578-4	2010	Inhibition of FGF receptors or of MEK1/2 and PI3K with specific inhibitors (PD173074, U0126 or LY294002, respectively) restored TSP-1 mRNA expression in the presence of FGF-8 in S115 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	thrombospondin 1	Homo sapiens	128-133
20370578-4	2010	Inhibition of FGF receptors or of MEK1/2 and PI3K with specific inhibitors (PD173074, U0126 or LY294002, respectively) restored TSP-1 mRNA expression in the presence of FGF-8 in S115 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	fibroblast growth factor 8	Homo sapiens	169-174
20370578-5	2010	Furthermore, U0126 and LY294002 increased TSP-1 mRNA expression in S115 cells over-expressing FGF-8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	thrombospondin 1	Homo sapiens	42-47
20370578-5	2010	Furthermore, U0126 and LY294002 increased TSP-1 mRNA expression in S115 cells over-expressing FGF-8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	fibroblast growth factor 8	Homo sapiens	94-99
20333651-6	2010	In addition, TNF-alpha-induced MMP-9 expression was also reduced by pretreatment with the inhibitor of PKCalpha (Go6983), c-Src (PP1), EGFR (AG1478), or PI3K (LY294002) or transfection with siRNAs of PKCalpha, Src, EGFR, Akt, p65, p300, and c-Jun.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	tumor necrosis factor	Homo sapiens	13-22
20333651-6	2010	In addition, TNF-alpha-induced MMP-9 expression was also reduced by pretreatment with the inhibitor of PKCalpha (Go6983), c-Src (PP1), EGFR (AG1478), or PI3K (LY294002) or transfection with siRNAs of PKCalpha, Src, EGFR, Akt, p65, p300, and c-Jun.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	matrix metallopeptidase 9	Homo sapiens	31-36
20333651-6	2010	In addition, TNF-alpha-induced MMP-9 expression was also reduced by pretreatment with the inhibitor of PKCalpha (Go6983), c-Src (PP1), EGFR (AG1478), or PI3K (LY294002) or transfection with siRNAs of PKCalpha, Src, EGFR, Akt, p65, p300, and c-Jun.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	protein kinase C alpha	Homo sapiens	103-111
20607860-8	2010	In SKOV3 cells, cisplatin alone and in combination with LY294002 resulted in a 6.3 and 7.1-fold reduction in the total amount of activated MMP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	matrix metallopeptidase 2	Homo sapiens	139-143
20607860-9	2010	TIMP1 expression decreased by 5.0, 6.6 and 28.4-fold with cisplatin, LY294002 and the combination respectively (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	TIMP metallopeptidase inhibitor 1	Homo sapiens	0-5
19650866-7	2010	Pretreatment of EpiDerm tissue constructs with LY294002, [an inhibitor of phosphatidylinositol-3 kinase and PI-3 kinase like kinases (PIKK)] completely abolished IR-induced 53BP1 foci formation and increased the apoptotic death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	tumor protein p53 binding protein 1	Homo sapiens	173-178
20451669-6	2010	On the other hand, PGN-induced iNOS and COX-2 up-regulation were attenuated by PI3-kinase inhibitors (LY294002 and wortmannin), and an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	nitric oxide synthase 2	Homo sapiens	31-35
20451669-6	2010	On the other hand, PGN-induced iNOS and COX-2 up-regulation were attenuated by PI3-kinase inhibitors (LY294002 and wortmannin), and an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	prostaglandin-endoperoxide synthase 2	Homo sapiens	40-45
20492357-8	2010	Lateral ventricular infusion of LY294002 before HPC blocked the increase in phosphorylated Akt and FoxOs and increased neuronal damage in HPC animals.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
20661471-8	2010	These results were further confirmed with the increased expression of p27(Kip1) and FOXO3a when treated with Ly294002 (10 microM) and increased luciferase expression with the siRNA and Ly294002 treatments when the FOXO binding promoter region of p27(Kip1) was used.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	interferon alpha inducible protein 27	Homo sapiens	70-73
20412823-5	2010	Furthermore, we showed that migration toward SDF-1 was attenuated by AMD3100 (specific inhibitor of CXCR4) and Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	C-X-C motif chemokine ligand 12	Homo sapiens	45-50
20412823-5	2010	Furthermore, we showed that migration toward SDF-1 was attenuated by AMD3100 (specific inhibitor of CXCR4) and Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	111-140
20382513-11	2010	However, HG-down-regulated MT-1 MMP expression was independent of activation of ERK1/2 and Akt when using their inhibitors of DB98059 (ERK1/2) and LY294002 (Akt) alone or in combination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	matrix metallopeptidase 14	Homo sapiens	27-35
20382513-11	2010	However, HG-down-regulated MT-1 MMP expression was independent of activation of ERK1/2 and Akt when using their inhibitors of DB98059 (ERK1/2) and LY294002 (Akt) alone or in combination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	AKT serine/threonine kinase 1	Homo sapiens	157-160
21038670-9	2010	(2) TNF-alpha increased the amplitude of the spontaneous Ca2+ transients in cultured ventricular myocytes from the neonatal rat; PI3-kinase inhibitor LY294002 could suppress the elevation induced by TNF-alpha, but calcium antagonist verapamil took the minor effects of TNF-alpha on [Ca2+]i metabolism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	tumor necrosis factor	Rattus norvegicus	4-13
21038670-9	2010	(2) TNF-alpha increased the amplitude of the spontaneous Ca2+ transients in cultured ventricular myocytes from the neonatal rat; PI3-kinase inhibitor LY294002 could suppress the elevation induced by TNF-alpha, but calcium antagonist verapamil took the minor effects of TNF-alpha on [Ca2+]i metabolism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	tumor necrosis factor	Rattus norvegicus	199-208
21038670-9	2010	(2) TNF-alpha increased the amplitude of the spontaneous Ca2+ transients in cultured ventricular myocytes from the neonatal rat; PI3-kinase inhibitor LY294002 could suppress the elevation induced by TNF-alpha, but calcium antagonist verapamil took the minor effects of TNF-alpha on [Ca2+]i metabolism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	tumor necrosis factor	Rattus norvegicus	199-208
20599723-12	2010	These results show that compared to the HGF-treated group, the differentiation rate of insulin-positive cells was significantly decreased in the HGF/LY294002 (PI3K inhibitor) group (13.47+/-1.57% vs. 33.47+/-1.34%, p&lt;0.05); however, the differentiation rate of insulin-positive cells was not significantly different in the HGF/PD98059 (MEK1/2 inhibitor) group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	hepatocyte growth factor	Rattus norvegicus	145-148
20599723-12	2010	These results show that compared to the HGF-treated group, the differentiation rate of insulin-positive cells was significantly decreased in the HGF/LY294002 (PI3K inhibitor) group (13.47+/-1.57% vs. 33.47+/-1.34%, p&lt;0.05); however, the differentiation rate of insulin-positive cells was not significantly different in the HGF/PD98059 (MEK1/2 inhibitor) group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	hepatocyte growth factor	Rattus norvegicus	145-148
20599723-12	2010	These results show that compared to the HGF-treated group, the differentiation rate of insulin-positive cells was significantly decreased in the HGF/LY294002 (PI3K inhibitor) group (13.47+/-1.57% vs. 33.47+/-1.34%, p&lt;0.05); however, the differentiation rate of insulin-positive cells was not significantly different in the HGF/PD98059 (MEK1/2 inhibitor) group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	mitogen activated protein kinase kinase 1	Rattus norvegicus	339-345
20661471-8	2010	These results were further confirmed with the increased expression of p27(Kip1) and FOXO3a when treated with Ly294002 (10 microM) and increased luciferase expression with the siRNA and Ly294002 treatments when the FOXO binding promoter region of p27(Kip1) was used.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	cyclin dependent kinase inhibitor 1B	Homo sapiens	74-78
20452332-6	2010	The neuroprotective effect of meloxicam on MPP(+)-induced apoptosis was abolished by a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, but not by a MEK inhibitor, PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	87-116
20661471-8	2010	These results were further confirmed with the increased expression of p27(Kip1) and FOXO3a when treated with Ly294002 (10 microM) and increased luciferase expression with the siRNA and Ly294002 treatments when the FOXO binding promoter region of p27(Kip1) was used.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	forkhead box O3	Homo sapiens	84-90
20661471-8	2010	These results were further confirmed with the increased expression of p27(Kip1) and FOXO3a when treated with Ly294002 (10 microM) and increased luciferase expression with the siRNA and Ly294002 treatments when the FOXO binding promoter region of p27(Kip1) was used.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	interferon alpha inducible protein 27	Homo sapiens	246-249
20661471-8	2010	These results were further confirmed with the increased expression of p27(Kip1) and FOXO3a when treated with Ly294002 (10 microM) and increased luciferase expression with the siRNA and Ly294002 treatments when the FOXO binding promoter region of p27(Kip1) was used.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	cyclin dependent kinase inhibitor 1B	Homo sapiens	250-254
20587517-5	2010	Knockdown of STAMP1 expression in LNCaP cells also induced significant apoptosis under basal conditions as well as in response to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) alone, or TRAIL + AKT inhibitor LY294002, previously established apoptotic agents in LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	226-234	STEAP2 metalloreductase	Homo sapiens	13-19
20578063-10	2010	Addition of specific inhibitors of MAPK (PD98059) and/or PI3K (LY294002) activation abolished or reduced EGF-induced effects in all experiments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	LOC521832	Bos taurus	105-108
20562903-10	2010	Compared with individual drug treatment, Akt phosphorylation and the ratio of p-eNOS/eNOS were up-regulated in the combination group, and this effect was inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	AKT serine/threonine kinase 1	Homo sapiens	41-44
20562903-10	2010	Compared with individual drug treatment, Akt phosphorylation and the ratio of p-eNOS/eNOS were up-regulated in the combination group, and this effect was inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	nitric oxide synthase 3	Homo sapiens	80-84
20562903-10	2010	Compared with individual drug treatment, Akt phosphorylation and the ratio of p-eNOS/eNOS were up-regulated in the combination group, and this effect was inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	nitric oxide synthase 3	Homo sapiens	85-89
20661723-6	2010	Nanog expression was diminished in the early stage by LY294002, a PI3K inhibitor, but was not affected in the late stage despite considerable inhibition of Akt phosphorylation and endoderm marker expression by the inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	Nanog homeobox	Mus musculus	0-5
20514428-6	2010	The suppressive activity of curcumin on alpha-MSH-induced melanogenesis was down-regulated by PD98059 and by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	pro-opiomelanocortin-alpha	Mus musculus	40-49
20564190-5	2010	Furthermore, the F-actin redistribution and assembly mediated by ligation with E-selectin were blocked by LY294002, a PI3K specific inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	selectin E	Homo sapiens	79-89
19757167-7	2010	Moreover LY294002 (a PI3K inhibitor) partially attenuated (P &lt; 0.05) ES-induced cell migration in wound healing assay while completely inhibited (P &lt; 0.05) ES-induced AKT1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	173-177
20439463-6	2010	Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 treatment in NS5A-Huh7 showed that the mTOR activation was independent of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-29
20439463-6	2010	Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 treatment in NS5A-Huh7 showed that the mTOR activation was independent of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	MIR7-3 host gene	Homo sapiens	74-78
20439463-6	2010	Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 treatment in NS5A-Huh7 showed that the mTOR activation was independent of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	mechanistic target of rapamycin kinase	Homo sapiens	95-99
20444901-6	2010	In HTLV-1-infected cell lines, cytoplasmic CDKN1A did not inhibit the cell cycle after UV irradiation; however, following treatment with LY294002, a PI3K inhibitor, CDKN1A was dephosphorylated and relocalized to the nucleus, resulting in suppression of the cell cycle.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	cyclin dependent kinase inhibitor 1A	Homo sapiens	43-49
20444901-6	2010	In HTLV-1-infected cell lines, cytoplasmic CDKN1A did not inhibit the cell cycle after UV irradiation; however, following treatment with LY294002, a PI3K inhibitor, CDKN1A was dephosphorylated and relocalized to the nucleus, resulting in suppression of the cell cycle.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	cyclin dependent kinase inhibitor 1A	Homo sapiens	165-171
20177740-9	2010	TGF-beta1-induced down-regulation of E-cadherin was recovered by a PI3K/Akt inhibitor, LY294002, without affecting the expression of FAK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	transforming growth factor beta 1	Homo sapiens	0-9
20177740-9	2010	TGF-beta1-induced down-regulation of E-cadherin was recovered by a PI3K/Akt inhibitor, LY294002, without affecting the expression of FAK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	cadherin 1	Homo sapiens	37-47
20177740-9	2010	TGF-beta1-induced down-regulation of E-cadherin was recovered by a PI3K/Akt inhibitor, LY294002, without affecting the expression of FAK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	72-75
20488538-9	2010	Inhibition of the PI3K-Akt pathway with the PI3K-specific inhibitor LY294002 leads to decreased sFlt1 levels and unchanged or increased VEGF and PlGF levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	23-26
20416349-11	2010	All of these effects of UII were prevented by LY294002, and urantide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	urotensin 2	Rattus norvegicus	24-27
20488538-9	2010	Inhibition of the PI3K-Akt pathway with the PI3K-specific inhibitor LY294002 leads to decreased sFlt1 levels and unchanged or increased VEGF and PlGF levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	vascular endothelial growth factor A	Homo sapiens	136-140
20488538-9	2010	Inhibition of the PI3K-Akt pathway with the PI3K-specific inhibitor LY294002 leads to decreased sFlt1 levels and unchanged or increased VEGF and PlGF levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	placental growth factor	Homo sapiens	145-149
20539939-4	2010	PI3K inhibitor LY294002 significantly decreased the expression of phospho-PI3K, phospho-Akt, phospho-ERK1/2, and cyclin D1 induced by apelin-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Rattus norvegicus	88-91
20547836-7	2010	Using the PI3K inhibitor, LY294002, cIAP2 up-regulation was suppressed and resistance to Smac mimetics-induced apoptosis was also overcome.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	baculoviral IAP repeat containing 3	Homo sapiens	36-41
20547836-7	2010	Using the PI3K inhibitor, LY294002, cIAP2 up-regulation was suppressed and resistance to Smac mimetics-induced apoptosis was also overcome.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	diablo IAP-binding mitochondrial protein	Homo sapiens	89-93
20228268-5	2010	ERK1/2 or Akt phosphorylation is blocked upstream by PD98059 or Wortmannin or LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	mitogen-activated protein kinase 3	Mus musculus	0-6
20228268-5	2010	ERK1/2 or Akt phosphorylation is blocked upstream by PD98059 or Wortmannin or LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	thymoma viral proto-oncogene 1	Mus musculus	10-13
20338993-7	2010	Both the SP 600125 (JNK inhibitor) and LY 294002 (PI-3K/Akt inhibitor) can inhibit chloramphenicol-induced c-Jun phosphorylation, MMP-13 expression, and cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	AKT serine/threonine kinase 1	Homo sapiens	56-59
20338993-7	2010	Both the SP 600125 (JNK inhibitor) and LY 294002 (PI-3K/Akt inhibitor) can inhibit chloramphenicol-induced c-Jun phosphorylation, MMP-13 expression, and cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-112
20338993-7	2010	Both the SP 600125 (JNK inhibitor) and LY 294002 (PI-3K/Akt inhibitor) can inhibit chloramphenicol-induced c-Jun phosphorylation, MMP-13 expression, and cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	matrix metallopeptidase 13	Homo sapiens	130-136
20418912-4	2010	LY294002 (PI3-kinase inhibitor) pre-treatment altered the post-translational modifications and the sub-cellular localization of p53.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor protein p53	Homo sapiens	128-131
20418912-5	2010	Although LY294002 increased the chemosensitivity of cells to low concentrations of adriamycin (adriamycin-low), it protected the cells from cytotoxicity induced by high concentrations of adriamycin (adriamycin-high) in a p53-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	tumor protein p53	Homo sapiens	221-224
20418912-6	2010	Further, we found that LY294002 completely abolished the activation of p53 target genes (particularly pro-apoptotic) under adriamycin-high conditions, whereas it only marginally repressed the p53 target genes under adriamycin-low conditions; in fact, it further activated the transcription of NOXA, HRK, APAF1 and CASP5 genes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	tumor protein p53	Homo sapiens	71-74
20418912-6	2010	Further, we found that LY294002 completely abolished the activation of p53 target genes (particularly pro-apoptotic) under adriamycin-high conditions, whereas it only marginally repressed the p53 target genes under adriamycin-low conditions; in fact, it further activated the transcription of NOXA, HRK, APAF1 and CASP5 genes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	293-297
20418912-6	2010	Further, we found that LY294002 completely abolished the activation of p53 target genes (particularly pro-apoptotic) under adriamycin-high conditions, whereas it only marginally repressed the p53 target genes under adriamycin-low conditions; in fact, it further activated the transcription of NOXA, HRK, APAF1 and CASP5 genes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	harakiri, BCL2 interacting protein	Homo sapiens	299-302
20418912-6	2010	Further, we found that LY294002 completely abolished the activation of p53 target genes (particularly pro-apoptotic) under adriamycin-high conditions, whereas it only marginally repressed the p53 target genes under adriamycin-low conditions; in fact, it further activated the transcription of NOXA, HRK, APAF1 and CASP5 genes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	apoptotic peptidase activating factor 1	Homo sapiens	304-309
20418912-6	2010	Further, we found that LY294002 completely abolished the activation of p53 target genes (particularly pro-apoptotic) under adriamycin-high conditions, whereas it only marginally repressed the p53 target genes under adriamycin-low conditions; in fact, it further activated the transcription of NOXA, HRK, APAF1 and CASP5 genes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	caspase 5	Homo sapiens	314-319
20383191-3	2010	This stimulatory effect depends on a functional phosphatidylinositol-3 kinase (PI3K) pathway because treatment of cells with the PI3K inhibitor, LY294002, abrogates CNK1-induced proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	connector enhancer of kinase suppressor of Ras 1	Homo sapiens	165-169
20539939-4	2010	PI3K inhibitor LY294002 significantly decreased the expression of phospho-PI3K, phospho-Akt, phospho-ERK1/2, and cyclin D1 induced by apelin-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mitogen activated protein kinase 3	Rattus norvegicus	101-107
20539939-4	2010	PI3K inhibitor LY294002 significantly decreased the expression of phospho-PI3K, phospho-Akt, phospho-ERK1/2, and cyclin D1 induced by apelin-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cyclin D1	Rattus norvegicus	113-122
20395448-6	2010	Addition of the phosphatidylinositol 3-kinase inhibitor LY294002 completely inhibits bromodeoxyuridine incorporation and cyclinD1 expression, confirming that in vitro growth of endometrial glands depends on phosphatidylinositol 3-kinase/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	cyclin D1	Mus musculus	121-129
20380832-4	2010	While the ER antagonist ICI182780 was able to abolish these effects, AKT phosphorylation induced by E2 was also inhibited by the PI3K inhibitor LY294002 and the SRC family inhibitor PP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	thymoma viral proto-oncogene 1	Mus musculus	69-72
20171992-6	2010	Interestingly, the pharmacological inhibition of PI3K (obtained with LY294002), hindered the capacity of U-II to induce a proangiogenic effect on HUVEC, suggesting that PI3K-dependent pathways also play a role in regulating the process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	urotensin 2	Homo sapiens	105-109
20451499-4	2010	Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	coagulation factor II, thrombin	Homo sapiens	0-8
20451499-4	2010	Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	coagulation factor II, thrombin	Homo sapiens	52-60
20451499-4	2010	Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	interleukin 6	Homo sapiens	84-88
20451499-4	2010	Thrombin activated Akt, PKC and MAPK in HAoSMC, and thrombin-mediated expression of IL-6 and CXCL8 was significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	C-X-C motif chemokine ligand 8	Homo sapiens	93-98
20299603-8	2010	We have demonstrated that exposure of HIMEC to low levels of irradiation induced Akt and mTOR phosphorylation, which was attenuated by curcumin, rapamycin, LY294002, and mTOR small interference RNA (siRNA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	AKT serine/threonine kinase 1	Homo sapiens	81-84
20299603-8	2010	We have demonstrated that exposure of HIMEC to low levels of irradiation induced Akt and mTOR phosphorylation, which was attenuated by curcumin, rapamycin, LY294002, and mTOR small interference RNA (siRNA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	mechanistic target of rapamycin kinase	Homo sapiens	89-93
20395448-6	2010	Addition of the phosphatidylinositol 3-kinase inhibitor LY294002 completely inhibits bromodeoxyuridine incorporation and cyclinD1 expression, confirming that in vitro growth of endometrial glands depends on phosphatidylinositol 3-kinase/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	thymoma viral proto-oncogene 1	Mus musculus	237-240
20351091-7	2010	Overexpression of EPS8 induced expression of the chemokine ligands CXCL5 and CXCL12 in a FOXM1-dependent manner, which was blocked by LY294002 or a dominant-negative form of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	epidermal growth factor receptor pathway substrate 8	Homo sapiens	18-22
20333467-9	2010	In addition, application of PI3K/Akt inhibitor LY294002 could abrogate both the protective effects of bilobalide against Abeta 1-42-, H(2)O(2)- and serum deprivation-induced apoptotic cell damage and bilobalide-induced increase in PI3K activity and levels of p-Akt (Ser473 and Thr308).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	33-36
20333467-9	2010	In addition, application of PI3K/Akt inhibitor LY294002 could abrogate both the protective effects of bilobalide against Abeta 1-42-, H(2)O(2)- and serum deprivation-induced apoptotic cell damage and bilobalide-induced increase in PI3K activity and levels of p-Akt (Ser473 and Thr308).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	261-264
20351091-7	2010	Overexpression of EPS8 induced expression of the chemokine ligands CXCL5 and CXCL12 in a FOXM1-dependent manner, which was blocked by LY294002 or a dominant-negative form of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	C-X-C motif chemokine ligand 5	Homo sapiens	67-72
20351091-7	2010	Overexpression of EPS8 induced expression of the chemokine ligands CXCL5 and CXCL12 in a FOXM1-dependent manner, which was blocked by LY294002 or a dominant-negative form of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	C-X-C motif chemokine ligand 12	Homo sapiens	77-83
20351091-7	2010	Overexpression of EPS8 induced expression of the chemokine ligands CXCL5 and CXCL12 in a FOXM1-dependent manner, which was blocked by LY294002 or a dominant-negative form of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	forkhead box M1	Homo sapiens	89-94
20232301-9	2010	Whereas these effects of SDF-1alpha on telomerase activity and expression of hTERT mRNA were significantly attenuated by CXCR4-specific peptide antagonist (AMD3100) and phosphoinositide 3-kinase (PI3K) inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	telomerase reverse transcriptase	Homo sapiens	77-82
20298690-7	2010	Inhibitor assay was carried out using LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	Phosphatidylinositol 3-kinase 92E	Drosophila melanogaster	50-79
20517899-6	2010	However, treatment with PI3-K inhibitor LY294002 significantly reversed the down-regulation of Runx2 expression and treatment with ERK inhibitor PD98059 remarkably decreased up-regulation of Osx and IGF-1 expression after insulin treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	RUNX family transcription factor 2	Homo sapiens	95-100
20378617-9	2010	The inhibitory effect of DHT on AQP-9 mRNA was attenuated by LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor (P = 0.0013).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	aquaporin 9	Homo sapiens	32-37
20385969-7	2010	Furthermore, TDGF-1 mediated a 3.8+/-0.4-fold increase in aldosterone secretion (n=4) that was specifically blocked by the phosphatidylinositol 3-kinase inhibitors wortmannin (50 nmol/L) and LY294002 (20 micromol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	191-199	teratocarcinoma-derived growth factor 1	Homo sapiens	13-19
20385969-8	2010	Finally, TDGF-1 protected H295R cells from apoptosis induced by staurosporine, causing a decrease in caspase-3 activity, a reduction in the inactivation of poly(ADP-ribose) polymerase, and an inhibition of DNA fragmentation, detected by the TUNEL reaction and fluorescence microscopy that was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	304-312	teratocarcinoma-derived growth factor 1	Homo sapiens	9-15
20232301-9	2010	Whereas these effects of SDF-1alpha on telomerase activity and expression of hTERT mRNA were significantly attenuated by CXCR4-specific peptide antagonist (AMD3100) and phosphoinositide 3-kinase (PI3K) inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	C-X-C motif chemokine receptor 4	Homo sapiens	121-126
19853610-9	2010	In contrast, NCAM mimetic peptide P2d activated AKT and significantly reduced oligomycin-induced cardiomyocyte death, which was abolished by treatment with the PI3K inhibitor LY-294002 as well as overexpression of the dominant-negative AKT mutant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-184	neural cell adhesion molecule 1	Rattus norvegicus	13-17
20556582-10	2010	The Dq, D0 and SF2 in LY294002-contained groups were lower than those in docetaxel or cisplatin+RT group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	serine and arginine rich splicing factor 1	Homo sapiens	15-18
19853610-9	2010	In contrast, NCAM mimetic peptide P2d activated AKT and significantly reduced oligomycin-induced cardiomyocyte death, which was abolished by treatment with the PI3K inhibitor LY-294002 as well as overexpression of the dominant-negative AKT mutant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-184	AKT serine/threonine kinase 1	Rattus norvegicus	48-51
19767100-5	2010	Tax-induced OPN activation was abrogated by treatment with LY294002 (PI3K inhibitor) or co-transfection with AKT siRNA, suggesting PI3K/AKT pathway is involved in Tax-mediated transactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	secreted phosphoprotein 1	Homo sapiens	12-15
20345719-7	2010	Western blot analysis showed that SAA, like the phosphoinositide 3-kinase (PI3K) inhibitors LY294002 and TGX-221, potently inhibited PI3K, as shown by reduced Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	serum amyloid A cluster	Mus musculus	34-37
20345719-7	2010	Western blot analysis showed that SAA, like the phosphoinositide 3-kinase (PI3K) inhibitors LY294002 and TGX-221, potently inhibited PI3K, as shown by reduced Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	48-73
20144629-2	2010	IGF-I-induced IGF-I receptor decrease was abolished by LY294002 (phosphoinositide 3-kinase inhibitor) and partially attenuated by rapamycin (an inhibitor of mammalian target of rapamycin [mTOR]).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	insulin like growth factor 1	Homo sapiens	0-5
20144629-2	2010	IGF-I-induced IGF-I receptor decrease was abolished by LY294002 (phosphoinositide 3-kinase inhibitor) and partially attenuated by rapamycin (an inhibitor of mammalian target of rapamycin [mTOR]).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	insulin like growth factor 1 receptor	Homo sapiens	14-28
20307544-8	2010	We confirmed the anti-apoptotic effect of PDGF-BB in monolayer cultures and observed that PI3-kinase inhibition with LY294002 attenuated PDGF-BB-mediated cardiomyocyte protection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	WAP four-disulfide core domain 15B	Rattus norvegicus	90-93
19685158-8	2010	Blockade of phosphoinositide-3 kinase (PI3K) by Ly294002 attenuates the effect of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	12-37
19685158-8	2010	Blockade of phosphoinositide-3 kinase (PI3K) by Ly294002 attenuates the effect of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	hepatocyte growth factor	Mus musculus	82-85
20560677-10	2010	Inhibition of Akt by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 induced PDCD4 activity and enhanced TRAIL sensitivity in TRAIL-resistant gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	14-17
20560677-10	2010	Inhibition of Akt by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 induced PDCD4 activity and enhanced TRAIL sensitivity in TRAIL-resistant gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	25-50
20560677-10	2010	Inhibition of Akt by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 induced PDCD4 activity and enhanced TRAIL sensitivity in TRAIL-resistant gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	programmed cell death 4	Homo sapiens	85-90
20560677-10	2010	Inhibition of Akt by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 induced PDCD4 activity and enhanced TRAIL sensitivity in TRAIL-resistant gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	TNF superfamily member 10	Homo sapiens	113-118
20560677-10	2010	Inhibition of Akt by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 induced PDCD4 activity and enhanced TRAIL sensitivity in TRAIL-resistant gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	TNF superfamily member 10	Homo sapiens	134-139
20428814-10	2010	Similarly, treatment of HepG2 cells with the PI3K/Akt pharmacological inhibitor, LY294002, potently suppressed cell migration and invasion as well as expression of MMPs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	50-53
20428814-10	2010	Similarly, treatment of HepG2 cells with the PI3K/Akt pharmacological inhibitor, LY294002, potently suppressed cell migration and invasion as well as expression of MMPs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	matrix metallopeptidase 2	Homo sapiens	164-168
19767100-5	2010	Tax-induced OPN activation was abrogated by treatment with LY294002 (PI3K inhibitor) or co-transfection with AKT siRNA, suggesting PI3K/AKT pathway is involved in Tax-mediated transactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	136-139
20587318-0	2010	[Effects of insulin and LY294002 inhibitors of PI3K on the regulations and expression of aquaporin 9 in normal liver cells].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	aquaporin 9	Homo sapiens	89-100
20484843-10	2010	Moreover, NaHS increased Akt phosphorylation, which was prevented with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (5 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Homo sapiens	25-28
20520761-10	2010	PRINCIPAL FINDINGS: LY294002, a PI3K/AKT pathway inhibitor, decreased both tumor growth in vivo and cell survival in Matrigel in MPA-independent tumors with higher AKT activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	thymoma viral proto-oncogene 1	Mus musculus	37-40
20520761-10	2010	PRINCIPAL FINDINGS: LY294002, a PI3K/AKT pathway inhibitor, decreased both tumor growth in vivo and cell survival in Matrigel in MPA-independent tumors with higher AKT activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	thymoma viral proto-oncogene 1	Mus musculus	164-167
20424113-5	2010	In addition, the combined treatment of DSF and LY294002 significantly inhibited the growth of the breast tumor xenograft in nude mice induced by MDA-MB-231 cells expressing mutant PIK3CA-H1047R and PIK3CA-E545K, whereas neither DSF nor LY294002 alone could significantly retard tumor growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	180-186
20424113-5	2010	In addition, the combined treatment of DSF and LY294002 significantly inhibited the growth of the breast tumor xenograft in nude mice induced by MDA-MB-231 cells expressing mutant PIK3CA-H1047R and PIK3CA-E545K, whereas neither DSF nor LY294002 alone could significantly retard tumor growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	198-204
20186967-9	2010	However, LY294002-induced apoptosis was considerably attenuated by incubation with R-568, indicating that other pathways might be major contributors to the survival mediated by CaR agonists.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	extracellular calcium-sensing receptor	Coturnix japonica	177-180
20377179-9	2010	Moreover, LY294002 (a PI3K inhibitor) significantly attenuated COX-2 expression and PGE(2) production in arsenite-treated RLE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	63-68
20139176-5	2010	The activation of HIF-1alpha by TNFalpha/IL-4 was countered by the phosphoinositol 3-kinase (PI3K) inhibitor LY-294002 and rapamycin, an antagonist of mammalian target of rapamycin (mTOR), but not by inhibition of the MAPK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
20139176-5	2010	The activation of HIF-1alpha by TNFalpha/IL-4 was countered by the phosphoinositol 3-kinase (PI3K) inhibitor LY-294002 and rapamycin, an antagonist of mammalian target of rapamycin (mTOR), but not by inhibition of the MAPK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-118	tumor necrosis factor	Homo sapiens	32-40
20139176-5	2010	The activation of HIF-1alpha by TNFalpha/IL-4 was countered by the phosphoinositol 3-kinase (PI3K) inhibitor LY-294002 and rapamycin, an antagonist of mammalian target of rapamycin (mTOR), but not by inhibition of the MAPK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-118	interleukin 4	Homo sapiens	41-45
20139176-5	2010	The activation of HIF-1alpha by TNFalpha/IL-4 was countered by the phosphoinositol 3-kinase (PI3K) inhibitor LY-294002 and rapamycin, an antagonist of mammalian target of rapamycin (mTOR), but not by inhibition of the MAPK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-118	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	67-91
20139176-5	2010	The activation of HIF-1alpha by TNFalpha/IL-4 was countered by the phosphoinositol 3-kinase (PI3K) inhibitor LY-294002 and rapamycin, an antagonist of mammalian target of rapamycin (mTOR), but not by inhibition of the MAPK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-118	mechanistic target of rapamycin kinase	Homo sapiens	182-186
20154257-5	2010	Pretreatment of MSCs and MSC(HO-1) with phosphatidylinositol 3-kinase (PI 3-kinase)/protein kinase B (Akt) pathway inhibitors such as LY-294002 (50 muM) or wortmannin (100 nM) significantly decreased VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-143	heme oxygenase 1	Rattus norvegicus	29-33
20154257-5	2010	Pretreatment of MSCs and MSC(HO-1) with phosphatidylinositol 3-kinase (PI 3-kinase)/protein kinase B (Akt) pathway inhibitors such as LY-294002 (50 muM) or wortmannin (100 nM) significantly decreased VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-143	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
19941984-4	2010	Both SP600125, an inhibitor of JNK, and LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), dose-dependently decreased LPS-induced Prx I mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	66-91
19941984-4	2010	Both SP600125, an inhibitor of JNK, and LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), dose-dependently decreased LPS-induced Prx I mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	toll-like receptor 4	Mus musculus	127-130
19941984-4	2010	Both SP600125, an inhibitor of JNK, and LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), dose-dependently decreased LPS-induced Prx I mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	peroxiredoxin 1	Mus musculus	139-144
20082630-8	2010	Inhibition of the PI3-K-Akt pathway with 1.4 mg/kg LY294002 caused a significant increase in the myocardial apoptotic index compared with hypoxia alone in the in vivo model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Rattus norvegicus	24-27
20144610-11	2010	Decreased TUNEL staining and the up-regulations of p-AKT signaling in retinas of ON-crushed, G-CSF-treated rats were blocked by intravitreal injections of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	AKT serine/threonine kinase 1	Rattus norvegicus	53-56
20089415-5	2010	Pre-incubation with the PI3-kinase inhibitor LY294002 or Wortmanin reversed the poly(I:C)-induced production and expression of BLyS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	peptidase inhibitor 3	Homo sapiens	24-27
20089415-5	2010	Pre-incubation with the PI3-kinase inhibitor LY294002 or Wortmanin reversed the poly(I:C)-induced production and expression of BLyS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	TNF superfamily member 13b	Homo sapiens	127-131
20144610-11	2010	Decreased TUNEL staining and the up-regulations of p-AKT signaling in retinas of ON-crushed, G-CSF-treated rats were blocked by intravitreal injections of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	colony stimulating factor 3	Rattus norvegicus	93-98
20411591-8	2010	Bradykinin-mediated migration was attenuated by phosphoinositide 3-kinase (PI-3 kinase)/AKT inhibitors LY 294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-112	kininogen 1	Homo sapiens	0-10
20225234-7	2010	The inhibition of the PI3K/Akt pathway by Ly294002 abrogated the protective effects induced by either Epo or atRA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	AKT serine/threonine kinase 1	Homo sapiens	27-30
20225234-7	2010	The inhibition of the PI3K/Akt pathway by Ly294002 abrogated the protective effects induced by either Epo or atRA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	erythropoietin	Homo sapiens	102-105
20200966-7	2010	T(3)-mediated Wnt-4 expression, beta-catenin activation, cell proliferation, and terminal differentiation of growth plate chondrocytes are partially prevented by the IGF1R inhibitor picropodophyllin as well as by the PI3K/Akt signaling inhibitors LY294002 and Akti1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	247-255	Wnt family member 4	Homo sapiens	14-19
20200966-7	2010	T(3)-mediated Wnt-4 expression, beta-catenin activation, cell proliferation, and terminal differentiation of growth plate chondrocytes are partially prevented by the IGF1R inhibitor picropodophyllin as well as by the PI3K/Akt signaling inhibitors LY294002 and Akti1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	247-255	insulin like growth factor 1 receptor	Homo sapiens	166-171
20411591-8	2010	Bradykinin-mediated migration was attenuated by phosphoinositide 3-kinase (PI-3 kinase)/AKT inhibitors LY 294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-112	AKT serine/threonine kinase 1	Homo sapiens	88-91
20184888-6	2010	This insulin-dependent titin-isoform shift was blocked by PI3K-inhibitor, LY294002, suggesting that insulin controls the cardiac titin-isoform pattern by activating PI3K/AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	titin	Rattus norvegicus	23-28
20082310-9	2010	TNF-alpha mediated an increase of kappaB-luciferase activity which was inhibited by Ly294002, wortmannin, Akt inhibitor, PDTC and TPCK or FAK, PI3K, and Akt mutant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	tumor necrosis factor	Homo sapiens	0-9
20184888-6	2010	This insulin-dependent titin-isoform shift was blocked by PI3K-inhibitor, LY294002, suggesting that insulin controls the cardiac titin-isoform pattern by activating PI3K/AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	titin	Rattus norvegicus	129-134
20184888-6	2010	This insulin-dependent titin-isoform shift was blocked by PI3K-inhibitor, LY294002, suggesting that insulin controls the cardiac titin-isoform pattern by activating PI3K/AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Rattus norvegicus	170-173
20212046-11	2010	LY294002 counteracted the PPAR-gamma silencing induced proliferation and migration in SHR-derived VSMCs, whereas active PI3K mutant had the opposite effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	26-36
19911116-8	2010	Administration of the PI3K pharmacological inhibitor LY294002 abrogated this effect by regulating FOXO3a expression and subcellular localization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	forkhead box O3	Homo sapiens	98-104
22966331-4	2010	BQ123, LY294002, SC203580 and AG1478 prevented the expression of COX-2 in the PC3 cells (P&lt;0.05), while BQ788 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	7-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
20177148-10	2010	LPA-induced VEGF secretion was inhibited by LY294002, whereas LPA-induced SDF-1 secretion was markedly attenuated by U0126, U73122, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	vascular endothelial growth factor A	Homo sapiens	12-16
20177148-10	2010	LPA-induced VEGF secretion was inhibited by LY294002, whereas LPA-induced SDF-1 secretion was markedly attenuated by U0126, U73122, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	C-X-C motif chemokine ligand 12	Homo sapiens	74-79
20352620-6	2010	Moreover, treatment with the PI3K inhibitor LY294002 completely blocked EPA-stimulatory action on apelin mRNA gene expression (p&lt;0.001), but not modified the stimulatory effect of EPA on basal apelin secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	apelin	Mus musculus	98-104
20372866-8	2010	LY294002, specific inhibitor of PI3K could suppress survivin and P-gp expression, decreased survivin promoter activity and enhanced cell sensitivity to drugs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	65-69
20170671-5	2010	Pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented activation of peripheral AKT by ephrinB1-Fc.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	thymoma viral proto-oncogene 1	Mus musculus	92-95
20170671-5	2010	Pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented activation of peripheral AKT by ephrinB1-Fc.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	ephrin B1	Mus musculus	99-107
20170671-8	2010	Furthermore, pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented ephrinB1-Fc-induced ERK activation in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	ephrin B1	Mus musculus	80-88
20170671-8	2010	Furthermore, pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented ephrinB1-Fc-induced ERK activation in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	mitogen-activated protein kinase 1	Mus musculus	100-103
20212046-12	2010	In contrast, reduced proliferation and migration by PPAR-gamma overexpression were reversed by the active PI3K mutant, and further inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	52-62
20423485-14	2010	However, application of LY294002 and rapamycin caused a dramatic reduction of epidermal growth factor-induced HCCR expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	epidermal growth factor	Homo sapiens	78-101
20361940-10	2010	The knockdown of survivin mRNA expression by its specific siRNA induced apoptosis of cancer cells when the cells were treated with LY294002 or taxol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	baculoviral IAP repeat containing 5	Gallus gallus	17-25
20064577-6	2010	The anti-apoptotic effect of IGF-1 was abrogated by LY294002, which indirectly inhibits phosphorylation of GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	insulin like growth factor 1	Homo sapiens	29-34
20064577-6	2010	The anti-apoptotic effect of IGF-1 was abrogated by LY294002, which indirectly inhibits phosphorylation of GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	glycogen synthase kinase 3 alpha	Homo sapiens	107-116
20412566-4	2010	However, our experiment results also demonstrated that apoptosis-induced LY294002 was directly regulated by caspase-9 activation pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	caspase 9	Homo sapiens	108-117
20412566-5	2010	CONCLUSION: These data suggested that PI3K inhibitor, LY294002, induced apoptosis by caspase-9 activation pathway and might be as a potentially useful target for therapeutic intervention in nasopharyngeal carcinoma patients.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	caspase 9	Homo sapiens	85-94
20412566-2	2010	METHODS: The activation of the PI3K/Akt and its effect on CNE-2Z cells in vivo and in vitro was investigated by MTT assay, flow cytometry, western blot, ELISA, terminal deoxyribonucleotide transferase-mediated nick-end labeling assays (TUNEL), and immunohistochemical analyses, using PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	300-308	AKT serine/threonine kinase 1	Homo sapiens	36-39
20412566-3	2010	RESULTS: The results showed that LY294002 inhibited the phosphorylating of Akt (S473), cell proliferation, and induced apoptosis in CNE-2Z cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Homo sapiens	75-78
20419107-3	2010	Specifically, we found that TRAIL treatment activates the Akt survival pathway and that inhibition of this pathway by the PI3K inhibitor LY294002 or knockdown of Akt sensitizes resistant cancer cells to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	TNF superfamily member 10	Homo sapiens	28-33
20397262-9	2010	LY294002 significantly suppressed proliferation of MIA-Paca2, NOR-P1, PANC-1, PK-45H, PK-1, PK-59 and KP-4 cells to 44.4% +/- 7.6%, 32.9% +/- 8.2%, 53.9% +/- 8.0%, 52.8% +/- 4.0%, 32.3% +/- 4.2%, 51.8% +/- 4.5%, and 30.6% +/- 9.4%, at 50 micromol/L, respectively (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	pyruvate kinase L/R	Homo sapiens	86-97
20397262-12	2010	LY294002 at 50 micromol/L suppressed motility of MIA-Paca2, NOR-P1, PANC-1, PK-45H, PK-1, PK-59 and KP-4 to 3.0% +/- 0.2%, 0%, 3.0% +/- 0.2%, 0%, 0%, 0% and 3% +/- 0.1%, respectively (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	pyruvate kinase L/R	Homo sapiens	84-95
20419107-3	2010	Specifically, we found that TRAIL treatment activates the Akt survival pathway and that inhibition of this pathway by the PI3K inhibitor LY294002 or knockdown of Akt sensitizes resistant cancer cells to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	AKT serine/threonine kinase 1	Homo sapiens	58-61
20419107-3	2010	Specifically, we found that TRAIL treatment activates the Akt survival pathway and that inhibition of this pathway by the PI3K inhibitor LY294002 or knockdown of Akt sensitizes resistant cancer cells to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	TNF superfamily member 10	Homo sapiens	203-208
20398401-10	2010	Finally, pretreatment with LY294002, a phosphoinositide 3-kinase (PI3K/AKT) inhibitor, disrupted cell-cell contacts and decreased cell number, but this was not the case in cells treated with the extracellular signal-regulated kinase (ERK) inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	mitogen-activated protein kinase 1	Homo sapiens	195-232
20398401-10	2010	Finally, pretreatment with LY294002, a phosphoinositide 3-kinase (PI3K/AKT) inhibitor, disrupted cell-cell contacts and decreased cell number, but this was not the case in cells treated with the extracellular signal-regulated kinase (ERK) inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	mitogen-activated protein kinase 1	Homo sapiens	234-237
20395207-8	2010	Growth factor-independent cell survival was stunted in CCN6 KD cells when treated with either human recombinant CCN6 protein or the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	cellular communication network factor 6	Homo sapiens	55-59
20108254-2	2010	Physcion-Glu-induced BMP-2 expression and mineralization were attenuated by LY294002, an inhibitor of PI3K that lies upstream of Akt and MAP kinases, suggesting that physcion-Glu induces osteoblast differentiation via PI3K-Akt/MAP kinase signaling pathways, which play important roles in inducing BMP-2 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	bone morphogenetic protein 2	Mus musculus	21-26
20108254-2	2010	Physcion-Glu-induced BMP-2 expression and mineralization were attenuated by LY294002, an inhibitor of PI3K that lies upstream of Akt and MAP kinases, suggesting that physcion-Glu induces osteoblast differentiation via PI3K-Akt/MAP kinase signaling pathways, which play important roles in inducing BMP-2 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	thymoma viral proto-oncogene 1	Mus musculus	129-132
20108254-2	2010	Physcion-Glu-induced BMP-2 expression and mineralization were attenuated by LY294002, an inhibitor of PI3K that lies upstream of Akt and MAP kinases, suggesting that physcion-Glu induces osteoblast differentiation via PI3K-Akt/MAP kinase signaling pathways, which play important roles in inducing BMP-2 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	thymoma viral proto-oncogene 1	Mus musculus	223-226
20108254-2	2010	Physcion-Glu-induced BMP-2 expression and mineralization were attenuated by LY294002, an inhibitor of PI3K that lies upstream of Akt and MAP kinases, suggesting that physcion-Glu induces osteoblast differentiation via PI3K-Akt/MAP kinase signaling pathways, which play important roles in inducing BMP-2 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	bone morphogenetic protein 2	Mus musculus	297-302
20079380-9	2010	Furthermore, LY294002, a PI3K inhibitor, abolished the anti-lipotoxic effect of ghrelin, as well as ghrelin-induced inhibition of JNK, while JNK inhibitor, SP600125 enhanced protective effect of ghrelin on MIN6 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	ghrelin	Mus musculus	80-87
20214883-3	2010	Specifically, we found that cisplatin treatment activates the Akt/mTOR survival pathway and that inhibition of this pathway by the PI3K inhibitor LY294002 or knockdown of Akt sensitizes ovarian cancer cells to cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	AKT serine/threonine kinase 1	Homo sapiens	62-65
20214883-3	2010	Specifically, we found that cisplatin treatment activates the Akt/mTOR survival pathway and that inhibition of this pathway by the PI3K inhibitor LY294002 or knockdown of Akt sensitizes ovarian cancer cells to cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	mechanistic target of rapamycin kinase	Homo sapiens	66-70
20079766-4	2010	Phosphatydilinositol-3 kinase (PI3-K) inhibitors Wortmanin or LY294002 reduced Ang II effect on tyr-phosphorylation of IRS-4 to a level comparable to that of Ins alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-29
20079766-4	2010	Phosphatydilinositol-3 kinase (PI3-K) inhibitors Wortmanin or LY294002 reduced Ang II effect on tyr-phosphorylation of IRS-4 to a level comparable to that of Ins alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	angiotensinogen	Homo sapiens	79-85
20079766-4	2010	Phosphatydilinositol-3 kinase (PI3-K) inhibitors Wortmanin or LY294002 reduced Ang II effect on tyr-phosphorylation of IRS-4 to a level comparable to that of Ins alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	insulin receptor substrate 4	Homo sapiens	119-124
20167866-6	2010	LTA-stimulated NF-kappaB translocation or cPLA(2) phosphorylation was attenuated by pretreatment with LY294002, SB202190, U0126, or SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	15-24
20150439-7	2010	LY294002, an inhibitor of phosphatidyl-inositol 3-kinase, caused a decrease in IGFBP-2 levels and enhanced apoptosis in combination with camptothecin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor binding protein 2	Homo sapiens	79-86
20167866-6	2010	LTA-stimulated NF-kappaB translocation or cPLA(2) phosphorylation was attenuated by pretreatment with LY294002, SB202190, U0126, or SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	42-49
20198331-4	2010	We showed that the killing efficacy of roscovitine and 16 other purines and potentiation of roscovitine-induced apoptosis by the PI3K inhibitor, LY294002, decreased with increasing corruption of the Rb and p53 pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	tumor protein p53	Homo sapiens	206-209
19997978-11	2010	The PI3K/Akt inhibitor LY294002 significantly increased the amount of p53 protein and attenuated the anti-apoptotic effects of CREG on MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Rattus norvegicus	9-12
19997978-11	2010	The PI3K/Akt inhibitor LY294002 significantly increased the amount of p53 protein and attenuated the anti-apoptotic effects of CREG on MSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	70-73
20213282-3	2010	Inhibition of PI3K/Akt by treatment with a PI3K-specific inhibitor (LY294002) prior to PRRSV infection reduced virus replication.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	19-22
20213282-4	2010	Furthermore, inhibition of PI3K/Akt by LY294002 at 90 min and 8 h after virus infection still significantly reduced virus production, suggesting that virus replication may be dependent on the activation of PI3K/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	32-35
20213282-4	2010	Furthermore, inhibition of PI3K/Akt by LY294002 at 90 min and 8 h after virus infection still significantly reduced virus production, suggesting that virus replication may be dependent on the activation of PI3K/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	211-214
20506627-5	2010	Blocking the activation of the PI3K/Akt pathway using LY294002 abolished Akt activation in response to cobalt chloride, suggesting that Akt phosphorylation by cobalt chloride is dependent on PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	36-39
20506627-5	2010	Blocking the activation of the PI3K/Akt pathway using LY294002 abolished Akt activation in response to cobalt chloride, suggesting that Akt phosphorylation by cobalt chloride is dependent on PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	73-76
20506627-5	2010	Blocking the activation of the PI3K/Akt pathway using LY294002 abolished Akt activation in response to cobalt chloride, suggesting that Akt phosphorylation by cobalt chloride is dependent on PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	73-76
20416175-10	2010	Interestingly, LY294002, not SB203580 and U0126, inhibited the up-regulation of fMLP-R and IL-1beta by IL-27.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 1 beta	Homo sapiens	91-99
20049896-8	2010	Inhibition of PI3-kinase with LY294002 abolished acute effect of EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	epidermal growth factor	Mus musculus	65-68
20054520-7	2010	In addition, LY294002, a PI3-K inhibitor, could prevent the quantitative and distributional changes of ZO-1 and RAGE and the increased permeability induced by HG and AGE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	tight junction protein 1	Rattus norvegicus	103-107
20054520-7	2010	In addition, LY294002, a PI3-K inhibitor, could prevent the quantitative and distributional changes of ZO-1 and RAGE and the increased permeability induced by HG and AGE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	advanced glycosylation end product-specific receptor	Rattus norvegicus	112-116
20085809-14	2010	The promotion of gliogenesis by FGF-2 was not only inhibited by U0126 but also by LY294002 and rapamycin, inhibitors of the Akt pathway, and by Akt-1 siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	fibroblast growth factor 2	Mus musculus	32-37
20177944-14	2010	LY294002 and PD98059 abolished the effect of POST on caspase 3 and 9 immunoreactivity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase-3	Cavia porcellus	53-68
20089132-8	2010	The insulin-induced decrease of phosphatase activities were PI3K-dependent as pre-treatment of ex vivo retinal cultures with LY294002 significantly reversed the insulin-induced inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	insulin	Homo sapiens	4-11
20089132-8	2010	The insulin-induced decrease of phosphatase activities were PI3K-dependent as pre-treatment of ex vivo retinal cultures with LY294002 significantly reversed the insulin-induced inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	insulin	Homo sapiens	161-168
20416175-10	2010	Interestingly, LY294002, not SB203580 and U0126, inhibited the up-regulation of fMLP-R and IL-1beta by IL-27.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 27	Homo sapiens	103-108
20361045-8	2010	The PDK1-IFPC::IFPN-AKT1 complex was sufficient for phosphorylation of known AKT substrates, and conferred resistance to inhibitors of PI3K (LY294002, PI103, GDC0941 and TGX286) but not inhibitors of the downstream TORC1 complex (rapamycin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	pyruvate dehydrogenase kinase 1	Homo sapiens	4-8
20361045-8	2010	The PDK1-IFPC::IFPN-AKT1 complex was sufficient for phosphorylation of known AKT substrates, and conferred resistance to inhibitors of PI3K (LY294002, PI103, GDC0941 and TGX286) but not inhibitors of the downstream TORC1 complex (rapamycin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Homo sapiens	20-24
20361045-8	2010	The PDK1-IFPC::IFPN-AKT1 complex was sufficient for phosphorylation of known AKT substrates, and conferred resistance to inhibitors of PI3K (LY294002, PI103, GDC0941 and TGX286) but not inhibitors of the downstream TORC1 complex (rapamycin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Homo sapiens	20-23
20361045-8	2010	The PDK1-IFPC::IFPN-AKT1 complex was sufficient for phosphorylation of known AKT substrates, and conferred resistance to inhibitors of PI3K (LY294002, PI103, GDC0941 and TGX286) but not inhibitors of the downstream TORC1 complex (rapamycin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	CREB regulated transcription coactivator 1	Homo sapiens	215-220
20154203-5	2010	This immature phenotype of SHIP(-/-) DCs could be reversed with the PI3K inhibitors LY294002 and wortmannin, suggesting that SHIP promotes DC maturation by reducing the levels of the PI3K second messenger phosphatidylinositol-3,4,5-trisphosphate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	inositol polyphosphate-5-phosphatase D	Mus musculus	27-31
20171952-4	2010	First, we treated mESCs with a combination of small molecules (Janus-associated tyrosine kinase inhibitor 1, LY294002, and CCG1423) and differentiated them into BMP7-positive cells, BMP7 being the presumed inducing factor for IM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	bone morphogenetic protein 7	Mus musculus	182-186
20154203-5	2010	This immature phenotype of SHIP(-/-) DCs could be reversed with the PI3K inhibitors LY294002 and wortmannin, suggesting that SHIP promotes DC maturation by reducing the levels of the PI3K second messenger phosphatidylinositol-3,4,5-trisphosphate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	inositol polyphosphate-5-phosphatase D	Mus musculus	125-129
20156043-7	2010	The stimulatory effect of EPO on hSR-BI/CLA-1 promoter activity was abrogated by LY294002, specific inhibitor of phosphatidylinositol-3 kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	erythropoietin	Homo sapiens	26-29
20338106-9	2010	Furthermore, nicotine induced activation of AKT and MAPK pathways, while inhibition of MAPK using U0126 and AKT by phosphatidylinositol 3-kinase inhibitor, LY294002, in part, blocked the antiapoptotic effects of nicotine against cisplatin and etoposide-induced apoptosis in NC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	AKT serine/threonine kinase 1	Homo sapiens	44-47
20338106-9	2010	Furthermore, nicotine induced activation of AKT and MAPK pathways, while inhibition of MAPK using U0126 and AKT by phosphatidylinositol 3-kinase inhibitor, LY294002, in part, blocked the antiapoptotic effects of nicotine against cisplatin and etoposide-induced apoptosis in NC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	AKT serine/threonine kinase 1	Homo sapiens	108-111
20156043-7	2010	The stimulatory effect of EPO on hSR-BI/CLA-1 promoter activity was abrogated by LY294002, specific inhibitor of phosphatidylinositol-3 kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	scavenger receptor class B member 1	Homo sapiens	33-39
20156043-7	2010	The stimulatory effect of EPO on hSR-BI/CLA-1 promoter activity was abrogated by LY294002, specific inhibitor of phosphatidylinositol-3 kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	scavenger receptor class B member 1	Homo sapiens	40-45
20404059-8	2010	Whereas the treatment with LY-294002 decreased the phosphorylation of Akt only, the treatment with UO-126 decreased ERK1/2, and that with PD-98059 decreased both Akt and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-36	AKT serine/threonine kinase 1	Rattus norvegicus	70-73
20179211-6	2010	Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA-treated mouse skin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	mitogen-activated protein kinase 8	Mus musculus	28-31
20179211-6	2010	Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA-treated mouse skin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	thymoma viral proto-oncogene 1	Mus musculus	35-38
20179211-6	2010	Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA-treated mouse skin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	jun proto-oncogene	Mus musculus	101-105
20179211-6	2010	Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA-treated mouse skin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	jun proto-oncogene	Mus musculus	137-142
20179211-6	2010	Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA-treated mouse skin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	FBJ osteosarcoma oncogene	Mus musculus	147-152
20080869-8	2010	Inhibitors of c-Src (PP2, 10 microm) and PI3K (LY294002, 25 microm) produced a significant decrease in OT-induced PGF(2 alpha) production and reduced COX2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	prostaglandin-endoperoxide synthase 2	Bos taurus	150-154
20080869-10	2010	Because LY294002 did not affect ERK1/2 phosphorylation, but inhibited PGF(2 alpha) production and down-regulated COX2 expression, it is likely that the Akt pathway is also involved in PGF(2 alpha) production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	prostaglandin-endoperoxide synthase 2	Bos taurus	113-117
20080869-10	2010	Because LY294002 did not affect ERK1/2 phosphorylation, but inhibited PGF(2 alpha) production and down-regulated COX2 expression, it is likely that the Akt pathway is also involved in PGF(2 alpha) production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	AKT serine/threonine kinase 1	Bos taurus	152-155
19866475-10	2010	The addition of a PI3K/AKT inhibitor Ly294002 reversed the CCL2 protection and was additive to docetaxel-induced toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	23-26
19815837-7	2010	Unexpectedly, treatment with thalidomide elicited an increase in fibronectin-induced Akt phosphorylation through phosphoinositide 3-kinase-independent pathways since thalidomide decreased fibronectin-induced phosphoinositide 3-kinase phosphorylation and reversed the inhibition of Akt phosphorylation achieved by the phosphoinositide 3-kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	369-377	fibronectin 1	Homo sapiens	65-76
19815837-7	2010	Unexpectedly, treatment with thalidomide elicited an increase in fibronectin-induced Akt phosphorylation through phosphoinositide 3-kinase-independent pathways since thalidomide decreased fibronectin-induced phosphoinositide 3-kinase phosphorylation and reversed the inhibition of Akt phosphorylation achieved by the phosphoinositide 3-kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	369-377	AKT serine/threonine kinase 1	Homo sapiens	85-88
19815837-7	2010	Unexpectedly, treatment with thalidomide elicited an increase in fibronectin-induced Akt phosphorylation through phosphoinositide 3-kinase-independent pathways since thalidomide decreased fibronectin-induced phosphoinositide 3-kinase phosphorylation and reversed the inhibition of Akt phosphorylation achieved by the phosphoinositide 3-kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	369-377	fibronectin 1	Homo sapiens	188-199
20126983-7	2010	PI3K inhibitor LY294002 blocks colocalization of Vav3 with P-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	vav guanine nucleotide exchange factor 3	Homo sapiens	49-53
20118282-3	2010	This effect of insulin to attenuate PAR(2)-mediated inflammation was reversed when cells were preincubated with LY294002 (a PI3K inhibitor) and GF 109203X (a pan-protein kinase C inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	insulin	Homo sapiens	15-22
20118282-3	2010	This effect of insulin to attenuate PAR(2)-mediated inflammation was reversed when cells were preincubated with LY294002 (a PI3K inhibitor) and GF 109203X (a pan-protein kinase C inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	coagulation factor II (thrombin) receptor-like 1	Mus musculus	36-42
19798745-6	2010	Furthermore, inhibitors of the MAPK and PI3K-Akt signaling pathways, U0126 and LY294002, attenuated the effects of PA6CM, significantly increasing the number of apoptotic cells and decreasing the number of viable cells among the ES cell-derived NS/PCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	mitogen-activated protein kinase 1	Mus musculus	31-35
19830833-8	2010	Blockade of ERK or Akt signaling with U0126 or LY294002 cancelled the OPC-protective effects of astrocyte-conditioned media.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	Eph receptor B1	Rattus norvegicus	12-15
19830833-8	2010	Blockade of ERK or Akt signaling with U0126 or LY294002 cancelled the OPC-protective effects of astrocyte-conditioned media.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
19874928-9	2010	Wortmannin and LY294002 also blocked HA oligosaccharide-induced serine and threonine Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	85-88
20080299-9	2010	The PI3K/AKT and p38 MAPK pathway inhibitors (LY294002 and SB202190, respectively) decreased dNK-CM-stimulated ICAM-1 induction, HTR8/SVneo migration, and reversed tube and network formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	9-12
20080299-9	2010	The PI3K/AKT and p38 MAPK pathway inhibitors (LY294002 and SB202190, respectively) decreased dNK-CM-stimulated ICAM-1 induction, HTR8/SVneo migration, and reversed tube and network formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	mitogen-activated protein kinase 14	Homo sapiens	17-20
20080299-9	2010	The PI3K/AKT and p38 MAPK pathway inhibitors (LY294002 and SB202190, respectively) decreased dNK-CM-stimulated ICAM-1 induction, HTR8/SVneo migration, and reversed tube and network formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	deoxyribonucleoside kinase	Drosophila melanogaster	93-96
20107192-9	2010	The phosphoinositide-3-kinase inhibitor LY294002 and dominant-negative Akt inhibited antiapoptotic action of BFT-induced and Pim-1 upregulation in high glucose-challenged cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	proviral integration site 1	Mus musculus	125-130
23675176-6	2010	An AKT specific inhibitor-AKTi-X (5 muM) and a PI3 K inhibitor-LY294002 (5 muM) were able to reverse AKT phosphorylation and PI3 K expression induced by Prox1, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	prospero homeobox protein 1	Cricetulus griseus	153-158
19950214-8	2010	Instead, phospho-Akt(ser473) was decreased during the phase coinciding with HIF1A degradation, and inhibition of PKB/Akt phosphorylation using PI3K inhibitor (LY294002) upregulated HIF1A ubiquitination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	181-186
20050973-11	2010	LY294002 blocked the increase in phospho-AKT evoked by Bai and abolished the associated protective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
20096933-6	2010	Moreover, inhibition of ERK1/2 and PI3/AKT kinase pathways with PD985009 and LY294002, respectively, suppresses the phosphorylation of ERK2 and AKT leading to the production of decreased amounts of IFN-gamma, IL-6 and NO mRNAs in CpG ODN(2007) stimulated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	peptidase inhibitor 3	Gallus gallus	35-38
20096933-6	2010	Moreover, inhibition of ERK1/2 and PI3/AKT kinase pathways with PD985009 and LY294002, respectively, suppresses the phosphorylation of ERK2 and AKT leading to the production of decreased amounts of IFN-gamma, IL-6 and NO mRNAs in CpG ODN(2007) stimulated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	interferon gamma	Gallus gallus	198-207
20096933-6	2010	Moreover, inhibition of ERK1/2 and PI3/AKT kinase pathways with PD985009 and LY294002, respectively, suppresses the phosphorylation of ERK2 and AKT leading to the production of decreased amounts of IFN-gamma, IL-6 and NO mRNAs in CpG ODN(2007) stimulated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	interleukin 6	Gallus gallus	209-213
19866475-10	2010	The addition of a PI3K/AKT inhibitor Ly294002 reversed the CCL2 protection and was additive to docetaxel-induced toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	C-C motif chemokine ligand 2	Homo sapiens	59-63
19070520-9	2010	Even if Akt activation is sufficient in promoting invasion, its inactivation by LY294002 (PI-3 kinase inhibitor) is less efficient on invasion than inhibition of N-cadherin and phospho-EGFR by GC-4 (monoclonal antibody) and gefitinib (anti-tyrosine kinase), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	8-11
20080299-9	2010	The PI3K/AKT and p38 MAPK pathway inhibitors (LY294002 and SB202190, respectively) decreased dNK-CM-stimulated ICAM-1 induction, HTR8/SVneo migration, and reversed tube and network formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	intercellular adhesion molecule 1	Homo sapiens	111-117
20510108-6	2010	PI3K inhibitor Wortmannin or Ly294002 inhibited the thrombin induced platelet aggregation and the above mentioned mDia1 translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	coagulation factor II, thrombin	Homo sapiens	52-60
20008098-8	2010	Inhibition of PI3K activity by its inhibitor LY294002 abrogated leptin-mediated PI3K/AKT signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	leptin	Homo sapiens	64-70
20008098-8	2010	Inhibition of PI3K activity by its inhibitor LY294002 abrogated leptin-mediated PI3K/AKT signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	85-88
19995565-11	2010	In addition, the phosphorylation induced by FLV and BDNF was blocked by LY294002, a selective inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	brain-derived neurotrophic factor	Rattus norvegicus	52-56
20510108-6	2010	PI3K inhibitor Wortmannin or Ly294002 inhibited the thrombin induced platelet aggregation and the above mentioned mDia1 translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	diaphanous related formin 1	Mus musculus	114-119
20163671-3	2010	In this study the effect of a PI3K inhibitor, LY294002, on the MAPK and p34(cdc2) kinase activities of matured porcine oocytes was examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	leucine rich repeat containing 59	Homo sapiens	72-75
19633047-7	2010	Growth of most HER2-amplified cells was inhibited by LY294002, regardless of PIK3CA genotype.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	erb-b2 receptor tyrosine kinase 2	Homo sapiens	15-19
20004186-5	2010	Neuron production was also attenuated in the chick neural tube following exposure to small molecule inhibitors of PI3-kinase (LY294002) or TOR (Rapamycin) activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	Pi3K21B	Drosophila melanogaster	114-124
20135719-9	2010	Inhibition of the phosphoinositide 3-kinase (PI3K)/Akt pathway by the PI3K inhibitor, LY294002, markedly suppressed HGF-stimulated invasion of both CCA cell lines, and inhibition of the ERK pathway by U0126 suppressed HGF-induced invasion of the KKU-M213 cell line but had a moderate effect on HuCCA-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	18-43
20135719-9	2010	Inhibition of the phosphoinositide 3-kinase (PI3K)/Akt pathway by the PI3K inhibitor, LY294002, markedly suppressed HGF-stimulated invasion of both CCA cell lines, and inhibition of the ERK pathway by U0126 suppressed HGF-induced invasion of the KKU-M213 cell line but had a moderate effect on HuCCA-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	AKT serine/threonine kinase 1	Homo sapiens	51-54
20135719-9	2010	Inhibition of the phosphoinositide 3-kinase (PI3K)/Akt pathway by the PI3K inhibitor, LY294002, markedly suppressed HGF-stimulated invasion of both CCA cell lines, and inhibition of the ERK pathway by U0126 suppressed HGF-induced invasion of the KKU-M213 cell line but had a moderate effect on HuCCA-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	hepatocyte growth factor	Homo sapiens	116-119
20135719-9	2010	Inhibition of the phosphoinositide 3-kinase (PI3K)/Akt pathway by the PI3K inhibitor, LY294002, markedly suppressed HGF-stimulated invasion of both CCA cell lines, and inhibition of the ERK pathway by U0126 suppressed HGF-induced invasion of the KKU-M213 cell line but had a moderate effect on HuCCA-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	mitogen-activated protein kinase 3	Homo sapiens	186-189
20135719-9	2010	Inhibition of the phosphoinositide 3-kinase (PI3K)/Akt pathway by the PI3K inhibitor, LY294002, markedly suppressed HGF-stimulated invasion of both CCA cell lines, and inhibition of the ERK pathway by U0126 suppressed HGF-induced invasion of the KKU-M213 cell line but had a moderate effect on HuCCA-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	hepatocyte growth factor	Homo sapiens	218-221
20157617-10	2010	The mTOR inhibitor, rapamycin, along with the SiRNA targeted to akt and the PI3K inhibitor, LY294002, decreased hVEGF secretion from RPE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	vascular endothelial growth factor A	Homo sapiens	112-117
20163671-7	2010	By additional treatment with LY294002 after Ca(2+) ionophore, both the MAPK and p34(cdc2) kinase activities were decreased in a time-dependent manner, concomitantly with improvement of pronuclear formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	leucine rich repeat containing 59	Homo sapiens	80-83
20163671-7	2010	By additional treatment with LY294002 after Ca(2+) ionophore, both the MAPK and p34(cdc2) kinase activities were decreased in a time-dependent manner, concomitantly with improvement of pronuclear formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	cyclin dependent kinase 1	Homo sapiens	84-88
20163671-3	2010	In this study the effect of a PI3K inhibitor, LY294002, on the MAPK and p34(cdc2) kinase activities of matured porcine oocytes was examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	cyclin dependent kinase 1	Homo sapiens	76-80
20163671-5	2010	Although 25 micromol/L LY294002 did not affect either the MAPK or p34(cdc2) kinase activities, 50 micromol/L LY294002 suppressed the PKB phosphorylation and slightly decreased MAPK activity, but not the p34(cdc2) kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	leucine rich repeat containing 59	Homo sapiens	203-206
20163671-5	2010	Although 25 micromol/L LY294002 did not affect either the MAPK or p34(cdc2) kinase activities, 50 micromol/L LY294002 suppressed the PKB phosphorylation and slightly decreased MAPK activity, but not the p34(cdc2) kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	cyclin dependent kinase 1	Homo sapiens	207-211
20163671-6	2010	Therefore the effect of 10 micromol/L Ca(2+) ionophore which was reported as inducing a transient decrease of p34(cdc2) kinase but not MAPK activities, was also examined in LY294002-treated oocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	leucine rich repeat containing 59	Homo sapiens	110-113
20163671-6	2010	Therefore the effect of 10 micromol/L Ca(2+) ionophore which was reported as inducing a transient decrease of p34(cdc2) kinase but not MAPK activities, was also examined in LY294002-treated oocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	cyclin dependent kinase 1	Homo sapiens	114-118
19809465-6	2010	Intraventricular administration of the ERK-1/-2 inhibitor, U0126, or the Akt inhibitor, LY294002, before injury showed that ERK was required for brain edema formation, and that rhEPO-induced reduction of edema could involve the ERK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	Eph receptor B1	Rattus norvegicus	124-127
20103665-10	2010	Inhibition of MAP/ERK kinase/ERK signaling with U0126 had no effect on radiosensitization, whereas inhibition of activated Akt with LY294002 (enhancement ratio, 1.2-1.8) or nelfinavir (enhancement ratio, 1.2-1.4) radiosensitized cells regardless of K-ras mutation status.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	AKT serine/threonine kinase 1	Homo sapiens	123-126
20404042-7	2010	Selective inhibitors of PDE3 (cilostazol) or PI3K (LY294002) rescued these effects of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	insulin	Homo sapiens	86-93
19906781-7	2010	However, the phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY-294002) inhibited the endothelium-dependent relaxant responses induced by both PPAR-beta agonists.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-134	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	13-42
19373754-8	2010	The PI3 kinase inhibitor LY 294002 blocked the increase in VEGF-A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-34	vascular endothelial growth factor A	Mus musculus	59-65
19887077-7	2010	Western blot analysis revealed that the PI-3K inhibitor LY294002 prevented the stimulating effect of BDNF on the PI-3K/Akt pathway, but had no effect on the ERK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	brain-derived neurotrophic factor	Rattus norvegicus	101-105
20487197-7	2010	Moreover, the specific Akt pathway inhibitor LY294002 blocked the hypopigmenting effect of sphingosylphosphorylcholine and abrogated the sphingosylphosphorylcholine-mediated down-regulation of microphthalmia-associated transcription factor (MITF), showing that the Akt pathway is involved in sphingosylphosphorylcholine-mediated melanin inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	thymoma viral proto-oncogene 1	Mus musculus	23-26
20487197-7	2010	Moreover, the specific Akt pathway inhibitor LY294002 blocked the hypopigmenting effect of sphingosylphosphorylcholine and abrogated the sphingosylphosphorylcholine-mediated down-regulation of microphthalmia-associated transcription factor (MITF), showing that the Akt pathway is involved in sphingosylphosphorylcholine-mediated melanin inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	melanogenesis associated transcription factor	Mus musculus	193-239
20487197-7	2010	Moreover, the specific Akt pathway inhibitor LY294002 blocked the hypopigmenting effect of sphingosylphosphorylcholine and abrogated the sphingosylphosphorylcholine-mediated down-regulation of microphthalmia-associated transcription factor (MITF), showing that the Akt pathway is involved in sphingosylphosphorylcholine-mediated melanin inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	melanogenesis associated transcription factor	Mus musculus	241-245
20487197-7	2010	Moreover, the specific Akt pathway inhibitor LY294002 blocked the hypopigmenting effect of sphingosylphosphorylcholine and abrogated the sphingosylphosphorylcholine-mediated down-regulation of microphthalmia-associated transcription factor (MITF), showing that the Akt pathway is involved in sphingosylphosphorylcholine-mediated melanin inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	thymoma viral proto-oncogene 1	Mus musculus	265-268
20010439-0	2010	Cytochalasin D, LY294002 and olomoucine synergize in promoting death of melanoma cells through activation of caspase-3 and apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	caspase 3	Homo sapiens	109-118
20010439-4	2010	We tested cell viability, terminal dUTP nick-end labeling and activation of caspase-3 upon exposure to cytochalasin D, LY294002 and olomoucine, added either alone or in various combinations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	caspase 3	Homo sapiens	76-85
20010439-8	2010	In particular, the triple combination of cytochalasin D+LY294002+olomoucine was almost as effective as staurosporine in inducing caspase-3 activity and apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	caspase 3	Homo sapiens	129-138
19962414-6	2010	Treatment with several signaling pathway-specific inhibitors revealed that the PI3 kinase inhibitor, LY294002, suppressed 6-OHDA- and MPP(+)-induced MMP-9 promoter activities, whereas the p38 MAPK inhibitor, SB203580, inhibited 6-OHDA-, but not MPP(+)-induced promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	M-phase phosphoprotein 6	Homo sapiens	134-137
19962414-6	2010	Treatment with several signaling pathway-specific inhibitors revealed that the PI3 kinase inhibitor, LY294002, suppressed 6-OHDA- and MPP(+)-induced MMP-9 promoter activities, whereas the p38 MAPK inhibitor, SB203580, inhibited 6-OHDA-, but not MPP(+)-induced promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	matrix metallopeptidase 9	Mus musculus	149-154
19962414-6	2010	Treatment with several signaling pathway-specific inhibitors revealed that the PI3 kinase inhibitor, LY294002, suppressed 6-OHDA- and MPP(+)-induced MMP-9 promoter activities, whereas the p38 MAPK inhibitor, SB203580, inhibited 6-OHDA-, but not MPP(+)-induced promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	M-phase phosphoprotein 6	Homo sapiens	245-248
20159686-6	2010	The protein expression of VEGF significantly increased after 50 micromol/L H(2)O(2) treatment (P&lt;0.05), but significantly decreased with pretreatment with the PI3K inhibitor Ly294002 (P&gt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	vascular endothelial growth factor A	Homo sapiens	26-30
19887077-7	2010	Western blot analysis revealed that the PI-3K inhibitor LY294002 prevented the stimulating effect of BDNF on the PI-3K/Akt pathway, but had no effect on the ERK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Rattus norvegicus	119-122
19887077-10	2010	However, concurrent exposure to PD98059 and LY294002 caused much greater inhibition of BDNF-evoked phosphorylation of GSK-3beta at serine 9 than did LY294002 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	brain-derived neurotrophic factor	Rattus norvegicus	87-91
19887077-10	2010	However, concurrent exposure to PD98059 and LY294002 caused much greater inhibition of BDNF-evoked phosphorylation of GSK-3beta at serine 9 than did LY294002 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	glycogen synthase kinase 3 beta	Rattus norvegicus	118-127
19887077-10	2010	However, concurrent exposure to PD98059 and LY294002 caused much greater inhibition of BDNF-evoked phosphorylation of GSK-3beta at serine 9 than did LY294002 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	brain-derived neurotrophic factor	Rattus norvegicus	87-91
19887077-10	2010	However, concurrent exposure to PD98059 and LY294002 caused much greater inhibition of BDNF-evoked phosphorylation of GSK-3beta at serine 9 than did LY294002 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	glycogen synthase kinase 3 beta	Rattus norvegicus	118-127
20798517-7	2010	LY294002, an inhibitor PI3K abolished TNF induced IL-4 release and phosphorylation of Akt in P815 cells, indicating Akt cell signalling pathway is involved in the event.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Mus musculus	38-41
20015475-8	2010	To investigate the involvement of additional signaling pathways, U87-MG cells were pretreated with wortmannin or LY294002 to inhibit the PI3-kinase/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Homo sapiens	148-151
19808899-9	2010	Similarly, pharmacological inhibition of the phosphoinositide 3-kinase (PI3K) pathway using LY294002 inhibited HIF-1 alpha and HIF-1 alpha targets in all cell lines, including those with B-RAF mutations (BcPAP and 8505c).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	45-70
19808899-9	2010	Similarly, pharmacological inhibition of the phosphoinositide 3-kinase (PI3K) pathway using LY294002 inhibited HIF-1 alpha and HIF-1 alpha targets in all cell lines, including those with B-RAF mutations (BcPAP and 8505c).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-122
19808899-9	2010	Similarly, pharmacological inhibition of the phosphoinositide 3-kinase (PI3K) pathway using LY294002 inhibited HIF-1 alpha and HIF-1 alpha targets in all cell lines, including those with B-RAF mutations (BcPAP and 8505c).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-138
19808899-9	2010	Similarly, pharmacological inhibition of the phosphoinositide 3-kinase (PI3K) pathway using LY294002 inhibited HIF-1 alpha and HIF-1 alpha targets in all cell lines, including those with B-RAF mutations (BcPAP and 8505c).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	187-192
19411121-9	2010	LY294002 abrogated all of the beneficial effects of MC transplantation with IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin-like growth factor 1	Rattus norvegicus	76-81
20978316-7	2010	The effects of the PI3K inhibitor LY294002 on TRAIL-induced apoptosis were similar to those of NVP-AEW541, further supporting a role for IGF-1R-mediated activation of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	TNF superfamily member 10	Homo sapiens	46-51
19951699-7	2010	Tg increased kinase activity of Akt to the same level as TSH, insulin and 5% serum, while LY294002 abolished Tg-induced growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	thyroglobulin	Rattus norvegicus	109-111
20823563-5	2010	Moreover, 7-O-MA stimulated the reactivation of insulin-mediated phosphorylation of phosphatidylinositol 3-kinase (PI3K)-linked protein kinase B (Akt/PKB) and adenosine 5"-monophosphate-activated protein kinase (AMPK) in high glucose-induced, insulin-resistant HepG2 cells, and this effect was blocked by either LY294002, a PI3K inhibitor, or compound C, an AMPK inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	312-320	insulin	Homo sapiens	48-55
20823563-5	2010	Moreover, 7-O-MA stimulated the reactivation of insulin-mediated phosphorylation of phosphatidylinositol 3-kinase (PI3K)-linked protein kinase B (Akt/PKB) and adenosine 5"-monophosphate-activated protein kinase (AMPK) in high glucose-induced, insulin-resistant HepG2 cells, and this effect was blocked by either LY294002, a PI3K inhibitor, or compound C, an AMPK inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	312-320	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	84-113
21364639-7	2010	Downregulation of PI3K by the expression of a dominant-negative mutant or inhibition by LY294002 abrogated the ability of alphaA-crystallin to phosphorylate Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Homo sapiens	157-160
20004734-5	2010	Treatment of these cells with PD98059 or LY294002 blocked ATL-1 effects, indicating the involvement of ERK-2 and PI3-K, both pathways associated with cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	atlastin GTPase 1	Homo sapiens	58-63
19882665-5	2010	Moreover, the effect of Sox2 on NPC self-renewal is completely inhibited by AG1478, a specific inhibitor for Egfr; it is also inhibited by LY294002 and U0126, selective antagonists for phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated kinase (Erk1/2), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	SRY-box transcription factor 2	Homo sapiens	24-28
19882665-5	2010	Moreover, the effect of Sox2 on NPC self-renewal is completely inhibited by AG1478, a specific inhibitor for Egfr; it is also inhibited by LY294002 and U0126, selective antagonists for phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated kinase (Erk1/2), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	mitogen-activated protein kinase 3	Homo sapiens	265-271
19962417-7	2010	The phosphorylation of Akt and CREB induced by KMUP-1 was inhibited by tyrosine kinase (TrK) inhibitor K252a and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	AKT serine/threonine kinase 1	Homo sapiens	23-26
19962417-7	2010	The phosphorylation of Akt and CREB induced by KMUP-1 was inhibited by tyrosine kinase (TrK) inhibitor K252a and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	cAMP responsive element binding protein 1	Homo sapiens	31-35
19962417-7	2010	The phosphorylation of Akt and CREB induced by KMUP-1 was inhibited by tyrosine kinase (TrK) inhibitor K252a and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	TXK tyrosine kinase	Homo sapiens	88-91
19726550-11	2010	In addition, blockade of the phosphatidylinositol-3 kinase/Akt pathway with LY294002 and silencing of Akt expression with Akt small interfering RNA induced p38 MAPK phosphorylation in the absence of HG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	59-62
19913504-6	2010	The PFF-induced stabilization of beta-catenin and activation of the beta-catenin signaling pathway was abolished by adding focal kinase inhibitor FAK inhibitor-14 (50 microM), or phosphatidyl inositol-3 kinase inhibitor LY-294002 (50 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-229	catenin beta 1	Homo sapiens	33-45
19913504-6	2010	The PFF-induced stabilization of beta-catenin and activation of the beta-catenin signaling pathway was abolished by adding focal kinase inhibitor FAK inhibitor-14 (50 microM), or phosphatidyl inositol-3 kinase inhibitor LY-294002 (50 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-229	catenin beta 1	Homo sapiens	68-80
21048307-8	2010	Moreover, the combination of Tan IIA and LY294002, a specific PI3K inhibitor, enhanced PARP cleavage of LNCaP and PC-3, but not in MDA-MB-231 breast cancer cells which do not contain detectable active AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	poly(ADP-ribose) polymerase 1	Homo sapiens	87-91
21048307-8	2010	Moreover, the combination of Tan IIA and LY294002, a specific PI3K inhibitor, enhanced PARP cleavage of LNCaP and PC-3, but not in MDA-MB-231 breast cancer cells which do not contain detectable active AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	chromobox 8	Homo sapiens	114-118
21048307-8	2010	Moreover, the combination of Tan IIA and LY294002, a specific PI3K inhibitor, enhanced PARP cleavage of LNCaP and PC-3, but not in MDA-MB-231 breast cancer cells which do not contain detectable active AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	201-204
21048308-8	2010	Consistently, LY294002, a specific PI3K inhibitor, enhanced the inactivation of HIF-1alpha and AKT by PGG in LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
21048308-8	2010	Consistently, LY294002, a specific PI3K inhibitor, enhanced the inactivation of HIF-1alpha and AKT by PGG in LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	95-98
20798517-7	2010	LY294002, an inhibitor PI3K abolished TNF induced IL-4 release and phosphorylation of Akt in P815 cells, indicating Akt cell signalling pathway is involved in the event.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 4	Mus musculus	50-54
20798517-7	2010	LY294002, an inhibitor PI3K abolished TNF induced IL-4 release and phosphorylation of Akt in P815 cells, indicating Akt cell signalling pathway is involved in the event.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	86-89
20798517-7	2010	LY294002, an inhibitor PI3K abolished TNF induced IL-4 release and phosphorylation of Akt in P815 cells, indicating Akt cell signalling pathway is involved in the event.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	116-119
20028744-7	2010	Blockage of both pathways by specific inhibitors (LY294002 and IkappaBalphaM, respectively) abrogated Id1-induced cell survival of keratinocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	inhibitor of DNA binding 1, HLH protein	Homo sapiens	102-105
19835871-9	2010	Pretreatment of gastric cancer cells with PI-3 kinase/Akt kinase inhibitor (kinase-dead Akt [DN-Akt], Akt siRNA, or LY294002) significantly inhibited BMP-2-induced EMT and invasiveness.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	54-57
19835871-9	2010	Pretreatment of gastric cancer cells with PI-3 kinase/Akt kinase inhibitor (kinase-dead Akt [DN-Akt], Akt siRNA, or LY294002) significantly inhibited BMP-2-induced EMT and invasiveness.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	bone morphogenetic protein 2	Homo sapiens	150-155
19769973-8	2010	Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by TLR ligands and the TLR3-specific induction of TRAIL and type 1 IFNs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	CD274 molecule	Homo sapiens	83-88
19769973-8	2010	Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by TLR ligands and the TLR3-specific induction of TRAIL and type 1 IFNs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	toll like receptor 3	Homo sapiens	112-116
19769973-8	2010	Inhibition of phosphoinositide 3 kinase with LY294002 blocked the up-regulation of PD-L1 by TLR ligands and the TLR3-specific induction of TRAIL and type 1 IFNs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	TNF superfamily member 10	Homo sapiens	139-144
19956899-10	2010	The activity of Akt was also inhibited in PCC-treated cells, and phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, LY294002, sensitized the cells to PCC-induced apoptosis indicating that the down-regulation of the Akt signaling pathway plays a key role in PCC-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	16-19
19956899-10	2010	The activity of Akt was also inhibited in PCC-treated cells, and phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, LY294002, sensitized the cells to PCC-induced apoptosis indicating that the down-regulation of the Akt signaling pathway plays a key role in PCC-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	65-94
19956899-10	2010	The activity of Akt was also inhibited in PCC-treated cells, and phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, LY294002, sensitized the cells to PCC-induced apoptosis indicating that the down-regulation of the Akt signaling pathway plays a key role in PCC-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	102-105
19956899-10	2010	The activity of Akt was also inhibited in PCC-treated cells, and phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, LY294002, sensitized the cells to PCC-induced apoptosis indicating that the down-regulation of the Akt signaling pathway plays a key role in PCC-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	102-105
19889638-6	2010	OSS also induced sustained activation of ERK, which was inhibited by the specific PI3K inhibitor LY294002 and was required for OSS-induced activation of mTOR/p70S6K and proliferation in MG63 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	mitogen-activated protein kinase 1	Homo sapiens	41-44
19889638-6	2010	OSS also induced sustained activation of ERK, which was inhibited by the specific PI3K inhibitor LY294002 and was required for OSS-induced activation of mTOR/p70S6K and proliferation in MG63 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	mechanistic target of rapamycin kinase	Homo sapiens	153-157
19889638-6	2010	OSS also induced sustained activation of ERK, which was inhibited by the specific PI3K inhibitor LY294002 and was required for OSS-induced activation of mTOR/p70S6K and proliferation in MG63 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	ribosomal protein S6 kinase B1	Homo sapiens	158-164
19618119-6	2010	In the glioma cell line U251HF, we further determined that blocking the PI3K/Akt signaling pathway with either adenoviral-mediated PTEN expression or LY294002 enhanced PAX6-mediated suppression of VEGFA in an additive manner; thus, PAX6-mediated suppression of VEGFA is not via the canonical pathway through HIF1A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	paired box 6	Homo sapiens	168-172
19724285-8	2010	TO901317 also significantly increased neurite outgrowth, and inhibition of the PI3K/Akt pathway by LY294002 decreased neurite outgrowth in both controls and TO901317-treated groups in cultured hypoxic PCN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	thymoma viral proto-oncogene 1	Mus musculus	84-87
19618119-6	2010	In the glioma cell line U251HF, we further determined that blocking the PI3K/Akt signaling pathway with either adenoviral-mediated PTEN expression or LY294002 enhanced PAX6-mediated suppression of VEGFA in an additive manner; thus, PAX6-mediated suppression of VEGFA is not via the canonical pathway through HIF1A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	vascular endothelial growth factor A	Homo sapiens	197-202
20389030-6	2010	By Western blotting analysis, we observed decreased intracellular levels of VEGF and HIF-1alpha under octreotide, rapamycin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	vascular endothelial growth factor A	Rattus norvegicus	76-80
20562516-6	2010	An Akt inhibitor, LY294002, and an NF-kappaB inhibitor, pyrrolidine dithiocarbamate, inhibited TNF-induced VCAM-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	tumor necrosis factor	Rattus norvegicus	95-98
20562516-6	2010	An Akt inhibitor, LY294002, and an NF-kappaB inhibitor, pyrrolidine dithiocarbamate, inhibited TNF-induced VCAM-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	vascular cell adhesion molecule 1	Rattus norvegicus	107-113
19961928-11	2010	Ang II-induced UB branching was abrogated by LY294002 (24+/-2.6 vs. 37+/-3.0, p&lt;0.05) or PD98059 (33+/-2.0 vs. 48+/-2.2, p&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
19766678-7	2010	When a specific inhibitor of phosphatidylinositol 3-kinase (PI3-K), LY294002, was added to 2DG plus NGF-treated cells, both the effects of NGF on 2DG-induced apoptosis and GRP78 expression were significantly diminished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	29-58
19766678-7	2010	When a specific inhibitor of phosphatidylinositol 3-kinase (PI3-K), LY294002, was added to 2DG plus NGF-treated cells, both the effects of NGF on 2DG-induced apoptosis and GRP78 expression were significantly diminished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	nerve growth factor	Rattus norvegicus	100-103
19911376-7	2010	The PI3K inhibitor LY294002 increases both spermatozoa motility parameters and the basal GSK3A phosphorylation, but does not affect either TCM- or 8Br-cAMP-stimulated GSK3A phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	glycogen synthase kinase 3 alpha	Homo sapiens	89-94
19893317-9	2010	TP508- and VEGF-induced NO production was decreased by inhibitors of PI-3K (LY294002) and Src (PP2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	vascular endothelial growth factor A	Homo sapiens	11-15
20117987-6	2010	LY294002 treatment prior to rHuEPO injection significantly abolished the effects of rHuEPO on caspase-9 and p-Akt immunohistochemical positivity and caspase-9 mRNA and p-Akt protein expressions (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 9	Rattus norvegicus	94-103
20117987-6	2010	LY294002 treatment prior to rHuEPO injection significantly abolished the effects of rHuEPO on caspase-9 and p-Akt immunohistochemical positivity and caspase-9 mRNA and p-Akt protein expressions (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	110-113
20117987-6	2010	LY294002 treatment prior to rHuEPO injection significantly abolished the effects of rHuEPO on caspase-9 and p-Akt immunohistochemical positivity and caspase-9 mRNA and p-Akt protein expressions (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 9	Rattus norvegicus	149-158
20117987-6	2010	LY294002 treatment prior to rHuEPO injection significantly abolished the effects of rHuEPO on caspase-9 and p-Akt immunohistochemical positivity and caspase-9 mRNA and p-Akt protein expressions (P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	170-173
20389030-4	2010	Octreotide and rapamycin induced a significant decrease in VEGF production by all three cell lines; LY294002 significantly inhibited VEGF production by STC-1 and INS-r3 only.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	vascular endothelial growth factor A	Rattus norvegicus	133-137
20389030-4	2010	Octreotide and rapamycin induced a significant decrease in VEGF production by all three cell lines; LY294002 significantly inhibited VEGF production by STC-1 and INS-r3 only.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	stanniocalcin 1	Rattus norvegicus	152-157
20389030-6	2010	By Western blotting analysis, we observed decreased intracellular levels of VEGF and HIF-1alpha under octreotide, rapamycin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	85-95
20389030-7	2010	For rapamycin and LY294002, this effect was likely mediated by the inhibition of the mTOR/HIF-1/VEGF pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	mechanistic target of rapamycin kinase	Rattus norvegicus	85-89
19766678-7	2010	When a specific inhibitor of phosphatidylinositol 3-kinase (PI3-K), LY294002, was added to 2DG plus NGF-treated cells, both the effects of NGF on 2DG-induced apoptosis and GRP78 expression were significantly diminished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	nerve growth factor	Rattus norvegicus	139-142
19766678-7	2010	When a specific inhibitor of phosphatidylinositol 3-kinase (PI3-K), LY294002, was added to 2DG plus NGF-treated cells, both the effects of NGF on 2DG-induced apoptosis and GRP78 expression were significantly diminished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	172-177
20389030-7	2010	For rapamycin and LY294002, this effect was likely mediated by the inhibition of the mTOR/HIF-1/VEGF pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	vascular endothelial growth factor A	Rattus norvegicus	96-100
19956887-12	2010	Moreover, inhibition of Akt by LY294002, a specific PI3K inhibitor, down-regulated c-FLIP expression in MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	24-27
19956885-8	2010	LY294002 and PD98059 inhibited SCF-induced Akt and Erk activation in H209 cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	KIT ligand	Homo sapiens	31-34
19956885-8	2010	LY294002 and PD98059 inhibited SCF-induced Akt and Erk activation in H209 cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	43-46
19956873-10	2010	Importantly, both ER antagonist ICI182,780 and phosphoinositide 3-kinase (PI3K) specific inhibitor LY294002 significantly inhibited the DEHP, BPA, or E2-induced cell migration and invasion, as well as the disregulation of MMP-2, MMP-9 and TIMP-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	matrix metallopeptidase 2	Homo sapiens	222-227
19956873-10	2010	Importantly, both ER antagonist ICI182,780 and phosphoinositide 3-kinase (PI3K) specific inhibitor LY294002 significantly inhibited the DEHP, BPA, or E2-induced cell migration and invasion, as well as the disregulation of MMP-2, MMP-9 and TIMP-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	matrix metallopeptidase 9	Homo sapiens	229-234
19956873-10	2010	Importantly, both ER antagonist ICI182,780 and phosphoinositide 3-kinase (PI3K) specific inhibitor LY294002 significantly inhibited the DEHP, BPA, or E2-induced cell migration and invasion, as well as the disregulation of MMP-2, MMP-9 and TIMP-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	TIMP metallopeptidase inhibitor 2	Homo sapiens	239-245
19956885-8	2010	LY294002 and PD98059 inhibited SCF-induced Akt and Erk activation in H209 cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 1	Homo sapiens	51-54
19956887-12	2010	Moreover, inhibition of Akt by LY294002, a specific PI3K inhibitor, down-regulated c-FLIP expression in MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	CASP8 and FADD like apoptosis regulator	Homo sapiens	83-89
19956885-12	2010	LY294002 but not PD98059 restored or enhanced AMR-sensitivity in SCF-treated H209 or untreated H69 cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	KIT ligand	Homo sapiens	65-68
21071999-6	2010	PFT-alpha-induced COX-2 expression was significantly decreased by UO126 and LY294002 in MDA-MB231 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
19820417-7	2010	Administration of LY294002 resulted in complete abrogation of CXCL12-induced proliferation in PanIN, 5143LM, and PANC-1 cells but not 5143PDA cells, whereas UO126 resulted in complete abrogation of CXCR4-enhanced proliferation in all cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	C-X-C motif chemokine ligand 12	Homo sapiens	62-68
20188023-5	2010	Experiments using the specific phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 revealed that PI3-K is strongly involved in FSH-induced aromatase expression in Sertoli cells from both 20- and 30-day-old rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	31-60
20369463-11	2010	And the protein expression of p-Akt (0.23 +/- 0.01) and p-mTOR (0.32 +/- 0.06) in LY294002 group was lower than p-Akt (0.63 +/- 0.02) and p-mTOR (0.71 +/- 0.02) in control group (P&lt;0.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	mechanistic target of rapamycin kinase	Homo sapiens	58-62
20369463-11	2010	And the protein expression of p-Akt (0.23 +/- 0.01) and p-mTOR (0.32 +/- 0.06) in LY294002 group was lower than p-Akt (0.63 +/- 0.02) and p-mTOR (0.71 +/- 0.02) in control group (P&lt;0.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	mechanistic target of rapamycin kinase	Homo sapiens	140-144
20369463-13	2010	CONCLUSION: LY294002 can inhibit the growth of HT1080 cells through PI3K-mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	mechanistic target of rapamycin kinase	Homo sapiens	73-77
19683795-5	2010	MATERIALS AND METHODS: The expression level of sPLA(2)-IIA was quantitatively measured by an enzyme-linked-immunosorbent-assay following stimulation of HUVECs with either thrombin or TNF-alpha in the absence and presence of the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor LY294002 and the cholesterol-depleting drug methyl-beta-cyclodextrin (MbetaCD).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	281-289	tumor necrosis factor	Homo sapiens	183-192
19683795-10	2010	Pretreatment of cells with either LY294002 or MbetaCD abolished the inhibitory activity of both APC and thrombin against sPLA(2)-IIA expression, suggesting that the protein C occupancy of EPCR confers a PI3-kinase dependent protective activity for thrombin such that its cleavage of the lipid-raft localized PAR-1 inhibits the TNF-alpha-mediated expression of sPLA(2)-IIA in HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	coagulation factor II, thrombin	Homo sapiens	104-112
19683795-10	2010	Pretreatment of cells with either LY294002 or MbetaCD abolished the inhibitory activity of both APC and thrombin against sPLA(2)-IIA expression, suggesting that the protein C occupancy of EPCR confers a PI3-kinase dependent protective activity for thrombin such that its cleavage of the lipid-raft localized PAR-1 inhibits the TNF-alpha-mediated expression of sPLA(2)-IIA in HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	protein C receptor	Homo sapiens	188-192
19683795-10	2010	Pretreatment of cells with either LY294002 or MbetaCD abolished the inhibitory activity of both APC and thrombin against sPLA(2)-IIA expression, suggesting that the protein C occupancy of EPCR confers a PI3-kinase dependent protective activity for thrombin such that its cleavage of the lipid-raft localized PAR-1 inhibits the TNF-alpha-mediated expression of sPLA(2)-IIA in HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	coagulation factor II, thrombin	Homo sapiens	248-256
19683795-10	2010	Pretreatment of cells with either LY294002 or MbetaCD abolished the inhibitory activity of both APC and thrombin against sPLA(2)-IIA expression, suggesting that the protein C occupancy of EPCR confers a PI3-kinase dependent protective activity for thrombin such that its cleavage of the lipid-raft localized PAR-1 inhibits the TNF-alpha-mediated expression of sPLA(2)-IIA in HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	coagulation factor II thrombin receptor	Homo sapiens	308-313
19683795-10	2010	Pretreatment of cells with either LY294002 or MbetaCD abolished the inhibitory activity of both APC and thrombin against sPLA(2)-IIA expression, suggesting that the protein C occupancy of EPCR confers a PI3-kinase dependent protective activity for thrombin such that its cleavage of the lipid-raft localized PAR-1 inhibits the TNF-alpha-mediated expression of sPLA(2)-IIA in HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	tumor necrosis factor	Homo sapiens	327-336
19819918-8	2010	Addition of the PI3K pathway inhibitor LY294002 (but not the MAPK pathway inhibitor PD98059) abrogated the increased expression of genes induced by IGF1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	insulin like growth factor 1	Bos taurus	148-152
20188023-5	2010	Experiments using the specific phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 revealed that PI3-K is strongly involved in FSH-induced aromatase expression in Sertoli cells from both 20- and 30-day-old rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	144-153
20398495-5	2010	However, compared with H/R group, these changes were significantly attenuated in GLP-1 + H/R group [the activity of LDH (128.47 +/- 7.96) U/L vs. (223.96 +/- 22.10) U/L, P &lt; 0.01, and cardiomyocyte apoptosis rate (2.84 +/- 2.56)% vs. (12.58 +/- 6.69)%, P &lt; 0.01, and Caspase-3 activity (36,809 +/- 4750) RLU vs. (57,602 +/- 9161) RLU, P &lt; 0.01], while LY294002 (PI3K inhibitor) and UO126 (MAPK inhibitor) could block the effects of GLP-1 in cardiomyocytes underwent H/R injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	361-369	glucagon	Rattus norvegicus	81-86
19553005-9	2009	MKP1-siRNA expression enhanced the chemosensitization effect of LY294002 and BAY11-7082 on H727 and H460 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	dual specificity phosphatase 1	Homo sapiens	0-4
20015408-3	2009	RESULTS: Here we show that in Xenopus eggs, a potent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase), LY294002 inhibits sperm-induced activation of the tyrosine kinase Src and a transient increase in the intracellular concentration of Ca2+ at fertilization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	66-95
20015408-3	2009	RESULTS: Here we show that in Xenopus eggs, a potent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase), LY294002 inhibits sperm-induced activation of the tyrosine kinase Src and a transient increase in the intracellular concentration of Ca2+ at fertilization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	97-108
20015408-3	2009	RESULTS: Here we show that in Xenopus eggs, a potent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase), LY294002 inhibits sperm-induced activation of the tyrosine kinase Src and a transient increase in the intracellular concentration of Ca2+ at fertilization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	SRC proto-oncogene, non-receptor tyrosine kinase L homeolog	Xenopus laevis	177-180
20015408-4	2009	LY294002 also inhibits sperm-induced dephosphorylation of mitogen-activated protein kinase, breakdown of cyclin B2 and Mos, and first embryonic cleavage, all of which are events of Ca2+-dependent egg activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin B2 S homeolog	Xenopus laevis	105-114
20015408-4	2009	LY294002 also inhibits sperm-induced dephosphorylation of mitogen-activated protein kinase, breakdown of cyclin B2 and Mos, and first embryonic cleavage, all of which are events of Ca2+-dependent egg activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	119-122
19843011-6	2009	Treatment of HeLa cells with inhibitors of PI3K (phosphatidylinositol 3-kinase) and PI4K (phosphatidylinositol 4-kinase) (wortmannin and LY294002) partially inhibited formation of STIM1 puncta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	stromal interaction molecule 1	Homo sapiens	180-185
20003467-10	2009	The phosphorylation level of Akt was apparently elevated in Lewis y-overexpressing cells and the inhibitor of PI3K, LY294002, dramatically inhibited the growth of Lewis y-overexpressing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	29-32
20003467-11	2009	In addition, the phosphorylation intensity and difference in phosphorylation intensity between cells with different expression of alpha1,2-FT were attenuated significantly by the monoantibody to Lewis y and by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	fucosyltransferase 2	Homo sapiens	130-141
20014456-8	2009	Apoptosis resistance towards TRAIL could be considerably reduced by adding the chemotherapeutic drugs 5-fluorouracil and doxorubicin as well as the kinase inhibitors LY294002 [inhibition of phosphoinositol-3-kinase (PI3K)], AG1478 (epidermal growth factor receptor kinase), PD98059 (MEK1), rapamycin (mammalian target of rapamycin) and the multi-kinase inhibitor Sorafenib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	TNF superfamily member 10	Homo sapiens	29-34
20014456-8	2009	Apoptosis resistance towards TRAIL could be considerably reduced by adding the chemotherapeutic drugs 5-fluorouracil and doxorubicin as well as the kinase inhibitors LY294002 [inhibition of phosphoinositol-3-kinase (PI3K)], AG1478 (epidermal growth factor receptor kinase), PD98059 (MEK1), rapamycin (mammalian target of rapamycin) and the multi-kinase inhibitor Sorafenib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	mitogen-activated protein kinase kinase 1	Homo sapiens	283-287
20014456-8	2009	Apoptosis resistance towards TRAIL could be considerably reduced by adding the chemotherapeutic drugs 5-fluorouracil and doxorubicin as well as the kinase inhibitors LY294002 [inhibition of phosphoinositol-3-kinase (PI3K)], AG1478 (epidermal growth factor receptor kinase), PD98059 (MEK1), rapamycin (mammalian target of rapamycin) and the multi-kinase inhibitor Sorafenib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	mechanistic target of rapamycin kinase	Homo sapiens	301-330
19700402-7	2009	In addition, GPVI-induced Akt phosphorylation in the presence of ADP antagonists was completely inhibited by PI3K inhibitor LY294002 and PI3Kbeta inhibitor TGX-221 indicating an essential role of PI3Kbeta in Akt activation directly downstream of GPVI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	glycoprotein 6 (platelet)	Mus musculus	13-17
19700402-7	2009	In addition, GPVI-induced Akt phosphorylation in the presence of ADP antagonists was completely inhibited by PI3K inhibitor LY294002 and PI3Kbeta inhibitor TGX-221 indicating an essential role of PI3Kbeta in Akt activation directly downstream of GPVI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	thymoma viral proto-oncogene 1	Mus musculus	26-29
19624598-9	2009	Furthermore, fibronectin-mediated protection of T24 cells was dependent on the activity of the PI3-K/Akt signalling pathway, and the protection could be abolished by the PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	fibronectin 1	Homo sapiens	13-24
20050188-10	2009	BK-induced IL-8 release was attenuated by inhibitors of phospholipase C (U73122), p38 (SB203580), JNK (SP600125), ERK 1/2 (PD98059) MAPKs, phosphoinositide 3-kinase (LY294002), NF-kappaB (BAY-117085) and by the glucocorticoid dexamethasone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	kininogen 1	Homo sapiens	0-2
20050188-10	2009	BK-induced IL-8 release was attenuated by inhibitors of phospholipase C (U73122), p38 (SB203580), JNK (SP600125), ERK 1/2 (PD98059) MAPKs, phosphoinositide 3-kinase (LY294002), NF-kappaB (BAY-117085) and by the glucocorticoid dexamethasone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
19923913-5	2009	Selective inhibition of the PI3K-AKT-mTOR pathway using pharmacologic inhibitors (LY294002, AKT inhibitor VIII, Rapamycin) significantly attenuated expression of p-AKT and p-70S6K, respectively and radiosensitized SKBR3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	33-36
19923913-5	2009	Selective inhibition of the PI3K-AKT-mTOR pathway using pharmacologic inhibitors (LY294002, AKT inhibitor VIII, Rapamycin) significantly attenuated expression of p-AKT and p-70S6K, respectively and radiosensitized SKBR3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	mechanistic target of rapamycin kinase	Homo sapiens	37-41
19923913-5	2009	Selective inhibition of the PI3K-AKT-mTOR pathway using pharmacologic inhibitors (LY294002, AKT inhibitor VIII, Rapamycin) significantly attenuated expression of p-AKT and p-70S6K, respectively and radiosensitized SKBR3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	ribosomal protein S6 kinase B1	Homo sapiens	172-179
19665053-6	2009	LY294002 inhibited EPO-induced tyrosine phosphorylation of Gab1 and its association with Grb2 in human primary EPO-sensitive erythroid cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	erythropoietin	Homo sapiens	19-22
19665053-6	2009	LY294002 inhibited EPO-induced tyrosine phosphorylation of Gab1 and its association with Grb2 in human primary EPO-sensitive erythroid cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GRB2 associated binding protein 1	Homo sapiens	59-63
19665053-6	2009	LY294002 inhibited EPO-induced tyrosine phosphorylation of Gab1 and its association with Grb2 in human primary EPO-sensitive erythroid cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	growth factor receptor bound protein 2	Homo sapiens	89-93
19665053-6	2009	LY294002 inhibited EPO-induced tyrosine phosphorylation of Gab1 and its association with Grb2 in human primary EPO-sensitive erythroid cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	erythropoietin	Homo sapiens	111-114
19622194-7	2009	Adding the PI3-kinase inhibitors wortmannin (10- 7 mol/l) or LY294002 (25 micromol/l) to 50 microm-oleate plus 300 microm-palmitate significantly reduced the beneficial effect of oleate against palmitate-induced insulin resistance, indicating that activation of PI3-kinase is involved in the protective effect of oleate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	insulin	Homo sapiens	212-219
19624598-9	2009	Furthermore, fibronectin-mediated protection of T24 cells was dependent on the activity of the PI3-K/Akt signalling pathway, and the protection could be abolished by the PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	AKT serine/threonine kinase 1	Homo sapiens	101-104
19837876-6	2009	An indicator of cell cycle progression, cyclin D2 mRNA was increased by 2- to 3-fold in ANP- or 8-Br-cGMP-treated INS-1E cells and islets, and these responses were inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	cyclin D2	Rattus norvegicus	40-49
19720143-4	2009	In this study, we found that Reck expression was up-regulated at high cell density, low serum, or after treatment with some kinase inhibitors, such as PP2 (Src inhibitor), LY294002 (PI3-kinase inhibitor), and PF573228 (FAK inhibitor), in mouse embryo fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	reversion-inducing-cysteine-rich protein with kazal motifs	Mus musculus	29-33
20120770-7	2009	The inhibition of phosphorylated Akt by LY294002 led to the inhibition of NF-kappaB in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	33-36
20120770-7	2009	The inhibition of phosphorylated Akt by LY294002 led to the inhibition of NF-kappaB in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	nuclear factor kappa B subunit 1	Homo sapiens	74-83
20120770-8	2009	Inhibition of Akt with LY294002 caused further increase in apoptosis of U937 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	14-17
19711359-5	2009	In addition, LY294002, a PI3-kinase inhibitor; SH-6, an Akt inhibitor; and PDTC, a nuclear factor kappa B (NF-kappaB) inhibitor, but not PD98059, an ERK1/2 inhibitor, abolished the protective effect of BDNF against cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	mitogen-activated protein kinase 3	Homo sapiens	149-155
19667121-9	2009	LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3-K) activity, inhibited culture- and IL-1beta-induced LN-332 expression in islets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	26-55
19667121-9	2009	LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3-K) activity, inhibited culture- and IL-1beta-induced LN-332 expression in islets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 beta	Homo sapiens	97-105
19643963-11	2009	LY294002 decreased beta1 integrin-mediated CLAN formation by 42%, and PP2 completely blocked it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	integrin subunit beta 1	Homo sapiens	19-33
19711359-7	2009	The blocking of BDNF"s actions by treatment with siRNA in all cases for TRKB and Bcl-2, LY294002, SH-6, and PDTC suppressed the enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	brain derived neurotrophic factor	Homo sapiens	16-20
20019838-7	2009	Involvement of the PI3K/Akt pathway was assessed using LY294002, a selective PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	thymoma viral proto-oncogene 1	Mus musculus	24-27
19795384-10	2009	The PI3K inhibitor LY294002 blocked IGF-I but not Dex induced REDD1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	insulin like growth factor 1	Homo sapiens	36-41
19551863-5	2009	Treatment with the PI3K inhibitor LY294002 attenuated the tumor promotion effects of Id-1, indicating that the effects were mediated by the PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	inhibitor of DNA binding 1, HLH protein	Homo sapiens	85-89
19551863-5	2009	Treatment with the PI3K inhibitor LY294002 attenuated the tumor promotion effects of Id-1, indicating that the effects were mediated by the PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	145-148
19892399-7	2009	PD98059 (a MEK1/2 inhibitor) at 20microM and LY294002 (a PI3K inhibitor) at 5microM attenuated FGF2- and VEGF-induced phosphorylation of ERK1/2 and AKT1, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	fibroblast growth factor 2	Homo sapiens	95-99
19892399-7	2009	PD98059 (a MEK1/2 inhibitor) at 20microM and LY294002 (a PI3K inhibitor) at 5microM attenuated FGF2- and VEGF-induced phosphorylation of ERK1/2 and AKT1, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	vascular endothelial growth factor A	Homo sapiens	105-109
19892399-7	2009	PD98059 (a MEK1/2 inhibitor) at 20microM and LY294002 (a PI3K inhibitor) at 5microM attenuated FGF2- and VEGF-induced phosphorylation of ERK1/2 and AKT1, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	mitogen-activated protein kinase 3	Homo sapiens	137-143
19892399-7	2009	PD98059 (a MEK1/2 inhibitor) at 20microM and LY294002 (a PI3K inhibitor) at 5microM attenuated FGF2- and VEGF-induced phosphorylation of ERK1/2 and AKT1, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	148-152
19892399-10	2009	Conversely, LY294002 dose-dependently inhibited FGF2-, but not VEGF-stimulated cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	fibroblast growth factor 2	Homo sapiens	48-52
19855934-4	2009	Inhibition of the PI3K/Akt pathway with LY294002 or Wortmannin led to a significant decrease in IGF-I-induced AR phosphorylation and total AR protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	thymoma viral proto-oncogene 1	Mus musculus	23-26
19855934-4	2009	Inhibition of the PI3K/Akt pathway with LY294002 or Wortmannin led to a significant decrease in IGF-I-induced AR phosphorylation and total AR protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	insulin-like growth factor 1	Mus musculus	96-101
19855934-4	2009	Inhibition of the PI3K/Akt pathway with LY294002 or Wortmannin led to a significant decrease in IGF-I-induced AR phosphorylation and total AR protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	androgen receptor	Mus musculus	110-112
19855934-4	2009	Inhibition of the PI3K/Akt pathway with LY294002 or Wortmannin led to a significant decrease in IGF-I-induced AR phosphorylation and total AR protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	androgen receptor	Mus musculus	139-141
19855934-5	2009	Furthermore, IGF-I-induced AR mRNA and skeletal alpha-actin mRNA were blocked by LY294002 or Wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	insulin-like growth factor 1	Mus musculus	13-18
19855934-5	2009	Furthermore, IGF-I-induced AR mRNA and skeletal alpha-actin mRNA were blocked by LY294002 or Wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	androgen receptor	Mus musculus	27-29
19855934-6	2009	Confocal images showed that IGF-I-induced AR translocation from cytosol to nucleus was inhibited significantly in response to treatment with LY294002 or Wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	insulin-like growth factor 1	Mus musculus	28-33
19855934-6	2009	Confocal images showed that IGF-I-induced AR translocation from cytosol to nucleus was inhibited significantly in response to treatment with LY294002 or Wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	androgen receptor	Mus musculus	42-44
20847591-3	2009	We have now shown that the insulin-induced increase in the abundance of SREBP1c mRNA in cultured AML12 mouse hepatocytes was largely abolished by LY294002, an inhibitor of phosphoinositide 3-kinase, but was reduced only slightly by rapamycin, an inhibitor of mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	insulin	Homo sapiens	27-34
19930596-6	2009	Treatment of Tregs with the mammalian target of rapamycin (mTOR) inhibitor, rapamycin or the PI3 kinase (PI3K) inhibitor LY294002 markedly suppressed granzyme B expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	granzyme B	Homo sapiens	150-160
20847591-3	2009	We have now shown that the insulin-induced increase in the abundance of SREBP1c mRNA in cultured AML12 mouse hepatocytes was largely abolished by LY294002, an inhibitor of phosphoinositide 3-kinase, but was reduced only slightly by rapamycin, an inhibitor of mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	sterol regulatory element binding transcription factor 1	Mus musculus	72-79
20847591-3	2009	We have now shown that the insulin-induced increase in the abundance of SREBP1c mRNA in cultured AML12 mouse hepatocytes was largely abolished by LY294002, an inhibitor of phosphoinositide 3-kinase, but was reduced only slightly by rapamycin, an inhibitor of mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	mechanistic target of rapamycin kinase	Mus musculus	259-263
19917087-12	2009	LH significantly increased CYP17A1 mRNA level in theca cells, whereas addition of LY294002 significantly decreased LH-induced CYP17A1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	steroid 17-alpha-hydroxylase/17,20 lyase	Bos taurus	126-133
19936256-8	2009	LY294002 blocked exercise-induced phosphorylation of Akt and downstream target proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	53-56
19769965-7	2009	Furthermore, the effect of CREG knockdown on SMC migration was abrogated in a dose-dependent manner by the addition of either IGF-II neutralizing antibody or the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	cellular repressor of E1A stimulated genes 1	Homo sapiens	27-31
19924283-8	2009	Hepcidin expression was also markedly and rapidly decreased by serum deprivation, independent of transferrin-bound iron, and by the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, indicating that growth factors are required for hepcidin expression in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	hepcidin antimicrobial peptide	Mus musculus	0-8
19887603-4	2009	Insulin-like growth factor I (IGF-I) and epidermal growth factor (EGF) stimulate KCC4 recruitment from a presumably inactive cytoplasmic pool of endoplasmic reticulum and Golgi to plasma membrane along actin cytoskeleton that is significantly inhibited by LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	256-264	insulin like growth factor 1	Homo sapiens	0-28
19887603-4	2009	Insulin-like growth factor I (IGF-I) and epidermal growth factor (EGF) stimulate KCC4 recruitment from a presumably inactive cytoplasmic pool of endoplasmic reticulum and Golgi to plasma membrane along actin cytoskeleton that is significantly inhibited by LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	256-264	insulin like growth factor 1	Homo sapiens	30-35
19887603-4	2009	Insulin-like growth factor I (IGF-I) and epidermal growth factor (EGF) stimulate KCC4 recruitment from a presumably inactive cytoplasmic pool of endoplasmic reticulum and Golgi to plasma membrane along actin cytoskeleton that is significantly inhibited by LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	256-264	solute carrier family 12 member 7	Homo sapiens	81-85
19679110-6	2009	Insulin stimulated phosphorylation of Akt and translocation of GLUT4 were blocked by pretreatment with the PI3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	insulin	Homo sapiens	0-7
19679110-6	2009	Insulin stimulated phosphorylation of Akt and translocation of GLUT4 were blocked by pretreatment with the PI3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	AKT serine/threonine kinase 1	Rattus norvegicus	38-41
19679110-6	2009	Insulin stimulated phosphorylation of Akt and translocation of GLUT4 were blocked by pretreatment with the PI3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	solute carrier family 2 member 4	Rattus norvegicus	63-68
19432589-11	2009	Infarct-sparing effect and post-ischaemic functional improvement induced by PAF pre-treatment were abolished by post-ischaemic infusion of either chelerythrine, LY294002 or atractyloside.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	PCNA clamp associated factor	Rattus norvegicus	76-79
19883517-8	2009	However, when LY294002 was used, p-Akt and p-Bad proteins inK562 cells showed a significant reduction, while no distinct variation was seen in the nonphosphorylated Akt and Bad protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	35-38
19726546-7	2009	Furthermore, the PI3K antagonist, LY294002, reduced TGF-beta1-stimulated COL1A2 promoter activity and Rac1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	transforming growth factor beta 1	Homo sapiens	52-61
19717552-4	2009	CSE stimulated the phosphorylation of c-Src, EGFR, PDGFR, and Akt, which were inhibited by pretreatment with the inhibitor of PKCalpha (Go6976 or Go6983), c-Src (PP1), EGFR (AG1478), PDGFR (AG1296), or PI3K (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	38-43
19717552-4	2009	CSE stimulated the phosphorylation of c-Src, EGFR, PDGFR, and Akt, which were inhibited by pretreatment with the inhibitor of PKCalpha (Go6976 or Go6983), c-Src (PP1), EGFR (AG1478), PDGFR (AG1296), or PI3K (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	platelet derived growth factor receptor beta	Homo sapiens	51-56
19717552-4	2009	CSE stimulated the phosphorylation of c-Src, EGFR, PDGFR, and Akt, which were inhibited by pretreatment with the inhibitor of PKCalpha (Go6976 or Go6983), c-Src (PP1), EGFR (AG1478), PDGFR (AG1296), or PI3K (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	AKT serine/threonine kinase 1	Homo sapiens	62-65
19717552-4	2009	CSE stimulated the phosphorylation of c-Src, EGFR, PDGFR, and Akt, which were inhibited by pretreatment with the inhibitor of PKCalpha (Go6976 or Go6983), c-Src (PP1), EGFR (AG1478), PDGFR (AG1296), or PI3K (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	protein kinase C alpha	Homo sapiens	126-134
19717552-6	2009	Furthermore, CSE-stimulated NF-kappaB p65 phosphorylation and translocation were also attenuated by pretreatment with Go6976, PP1, AG1478, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	nuclear factor kappa B subunit 1	Homo sapiens	28-37
19717552-6	2009	Furthermore, CSE-stimulated NF-kappaB p65 phosphorylation and translocation were also attenuated by pretreatment with Go6976, PP1, AG1478, AG1296, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	RELA proto-oncogene, NF-kB subunit	Homo sapiens	38-41
19657064-7	2009	For both cell types, p-Akt was higher in the ZD than in the ZN cells and was normalized to that of the ZN cells by treatment with a PI3K inhibitor, LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-157	AKT serine/threonine kinase 1	Homo sapiens	23-26
19726546-7	2009	Furthermore, the PI3K antagonist, LY294002, reduced TGF-beta1-stimulated COL1A2 promoter activity and Rac1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	collagen type I alpha 2 chain	Homo sapiens	73-79
19726546-7	2009	Furthermore, the PI3K antagonist, LY294002, reduced TGF-beta1-stimulated COL1A2 promoter activity and Rac1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	Rac family small GTPase 1	Homo sapiens	102-106
20032392-8	2009	Apoptosis induced by the combined treatment was markedly increased by the phosphatidylinositol-3"-kinase inhibitor, LY294002 (Akt-upstream inhibitor), through the mitochondrial amplification step and caspase activation, suggesting that interactions of the synergistic effect were at least partially mediated through the Akt-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	126-129
19757065-9	2009	The cytoprotection of IMD(1-53) was abolished with LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	adrenomedullin 2	Rattus norvegicus	22-25
20032392-8	2009	Apoptosis induced by the combined treatment was markedly increased by the phosphatidylinositol-3"-kinase inhibitor, LY294002 (Akt-upstream inhibitor), through the mitochondrial amplification step and caspase activation, suggesting that interactions of the synergistic effect were at least partially mediated through the Akt-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	320-323
19631775-12	2009	In addition, NARS-induced protection against apoptosis was abolished by the treatment of PI3K inhibitors, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	asparaginyl-tRNA synthetase	Mus musculus	13-17
19881297-7	2009	However, these protective effects were abolished in the presence of either LY294002 or PD98059, which was accompanied by the prevention of PKB/Akt and ERK 1/2 phosphorylation, and reduction of myocardial nicotinamide adenine dinucleotide (NAD+) content.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	mitogen activated protein kinase 3	Rattus norvegicus	151-158
19588183-6	2009	The cardiomyocytes treated with T3 demonstrated a rapid activation of Akt/GSK-3beta/mTOR signaling pathway, which was completely inhibited by the use of PI3K inhibitors (LY294002, 10 microM and Wortmannin, 200 nM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Homo sapiens	70-73
19588183-6	2009	The cardiomyocytes treated with T3 demonstrated a rapid activation of Akt/GSK-3beta/mTOR signaling pathway, which was completely inhibited by the use of PI3K inhibitors (LY294002, 10 microM and Wortmannin, 200 nM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	glycogen synthase kinase 3 beta	Homo sapiens	74-83
19588183-6	2009	The cardiomyocytes treated with T3 demonstrated a rapid activation of Akt/GSK-3beta/mTOR signaling pathway, which was completely inhibited by the use of PI3K inhibitors (LY294002, 10 microM and Wortmannin, 200 nM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	mechanistic target of rapamycin kinase	Homo sapiens	84-88
18941890-11	2009	Inhibition of Erk1/2 by U0126 (10 microM) decreased p-ser118-ERalpha by 51.7 +/- 8.5% and decreased p-ser167-ERalpha by 41.9 +/- 16.9% whereas inhibition of Akt by LY294002 (20 microM) and wortmannin (500 nM) or by siRNA knock-down, had no effect on p-ser167-ERalpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	mitogen-activated protein kinase 3	Homo sapiens	14-20
19843849-8	2009	However, the rate of HIF-1alpha protein synthesis was higher in cells with a KRAS mutation, and this was suppressed by the phosphoinositide 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	KRAS proto-oncogene, GTPase	Homo sapiens	77-81
19826044-6	2009	However, pretreatment of C4-2 cells with the phosphoinositide 3-kinase inhibitor LY294002 restored paclitaxel inhibition of the AR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	androgen receptor	Homo sapiens	128-130
19457607-7	2009	The PI3K/Akt inhibitor LY294002 significantly increased the amount of p53 protein and ATO-induced apoptosis in both cell lines and decreased G2/M phase arrest of MGC803 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	9-12
19457607-7	2009	The PI3K/Akt inhibitor LY294002 significantly increased the amount of p53 protein and ATO-induced apoptosis in both cell lines and decreased G2/M phase arrest of MGC803 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	tumor protein p53	Homo sapiens	70-73
19843849-8	2009	However, the rate of HIF-1alpha protein synthesis was higher in cells with a KRAS mutation, and this was suppressed by the phosphoinositide 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
19632318-8	2009	Pretreatment with the phosphatidylinositol 3-kinase inhibitor Ly294002 and mTOR inhibitor rapamycin restored the ability of PDBu to downregulate PKC delta in HeLa/CP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	protein kinase C delta	Homo sapiens	145-154
19814765-7	2009	Moreover, increases in the phosphorylation of glycogen synthase kinase 3beta, accumulation/activation of beta-catenin, and collagen synthesis induced by alpha-defensin-1 and alpha-defensin-2 were prevented by p38 mitogen-activated protein kinase inhibitor SB203580 and phosphoinositide 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	glycogen synthase kinase 3 beta	Homo sapiens	46-76
19814765-7	2009	Moreover, increases in the phosphorylation of glycogen synthase kinase 3beta, accumulation/activation of beta-catenin, and collagen synthesis induced by alpha-defensin-1 and alpha-defensin-2 were prevented by p38 mitogen-activated protein kinase inhibitor SB203580 and phosphoinositide 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	catenin beta 1	Homo sapiens	105-117
19814765-7	2009	Moreover, increases in the phosphorylation of glycogen synthase kinase 3beta, accumulation/activation of beta-catenin, and collagen synthesis induced by alpha-defensin-1 and alpha-defensin-2 were prevented by p38 mitogen-activated protein kinase inhibitor SB203580 and phosphoinositide 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	305-313	mitogen-activated protein kinase 14	Homo sapiens	209-212
19585524-10	2009	On the other hand, the PI3K/Akt inhibitor LY 294002 potentiated apoptosis induced by PFAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-51	thymoma viral proto-oncogene 1	Mus musculus	28-31
20009893-3	2009	After exposure to 17beta-estradiol and/or to the mitogen-activated protein kinase (MAPK) inhibitor U0126 and to the PI3K inhibitor LY294002, the expression of KLK4 in the endometrial cancer cell lines KLE and RL95-2 was detected with quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and Western blot.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	kallikrein related peptidase 4	Homo sapiens	159-163
20009893-7	2009	Quantitative reverse transcriptase PCR and Western blot analysis showed that estrogen can up-regulate the expression of KLK4 in endometrial cancer cell lines KLE and RL95-2, and the up-regulation effect of 17beta-estradiol on KLK4 can be inhibited by U0126 in the 2 endometrial cancer cell lines but not by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	307-315	kallikrein related peptidase 4	Homo sapiens	120-124
19602048-5	2009	Moreover, LY294002 that is a specific inhibitor of phosphatidylinositol 3-kinase (PI3K) significantly reduced the enhanced expression of HIF-1alpha, EPO and 136p-Bad induced by GB and IP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	hypoxia inducible factor 1, alpha subunit	Mus musculus	137-147
19602048-5	2009	Moreover, LY294002 that is a specific inhibitor of phosphatidylinositol 3-kinase (PI3K) significantly reduced the enhanced expression of HIF-1alpha, EPO and 136p-Bad induced by GB and IP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	erythropoietin	Mus musculus	149-152
19669229-8	2009	LY294002 significantly inhibited the PI3K-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	42-45
19737348-7	2009	Additionally, Akt, p70 ribosomal protein S6 kinase, and S6 ribosomal protein were also phosphorylated upon sPLA(2)-IIA treatment, effect that was abrogated by N-acetylcysteine or LY294002 treatment indicating that ROS and phosphatidylinositol 3 kinase are upstream signaling regulators.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	AKT serine/threonine kinase 1	Homo sapiens	14-17
19329185-2	2009	Treatment of Imatinib or LY294002 reduced Skp2 mRNA in BCR-ABL-positive K562 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	S-phase kinase associated protein 2	Homo sapiens	42-46
19329185-2	2009	Treatment of Imatinib or LY294002 reduced Skp2 mRNA in BCR-ABL-positive K562 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	55-62
19669229-12	2009	LY294002 effectively inhibits the PI3K-Akt pathway, suppresses NE tumor markers, and decreases cellular proliferation via apoptosis in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	39-42
19482057-3	2009	IGF-I- and b-insulin-induced oocyte maturation was significantly inhibited by Wortmannin and LY294002, two mechanistically different specific inhibitors of PI3 kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	insulin like growth factor 1	Homo sapiens	0-5
19631197-8	2009	A PI3K-specific inhibitor, LY294002, abolished the phosphorylated Akt and OGG1 expressions induced by butin, suggesting that OGG1 induction by butin involves the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	66-69
19631197-8	2009	A PI3K-specific inhibitor, LY294002, abolished the phosphorylated Akt and OGG1 expressions induced by butin, suggesting that OGG1 induction by butin involves the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	8-oxoguanine DNA glycosylase	Homo sapiens	74-78
19631197-8	2009	A PI3K-specific inhibitor, LY294002, abolished the phosphorylated Akt and OGG1 expressions induced by butin, suggesting that OGG1 induction by butin involves the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	8-oxoguanine DNA glycosylase	Homo sapiens	125-129
19631197-8	2009	A PI3K-specific inhibitor, LY294002, abolished the phosphorylated Akt and OGG1 expressions induced by butin, suggesting that OGG1 induction by butin involves the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	167-170
19859997-8	2009	CONCLUSION: The class I PI3K inhibitor LY294002 could inhibit the invasiveness of gastric cancer cells by downregulating the expression of MMP-2, MMP-9, and VEGF, and reducing MVD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	matrix metallopeptidase 2	Homo sapiens	139-144
19648963-8	2009	Treatment of lung tumor-bearing mice with the phosphoinositol-3 kinase inhibitor LY294002 induced a rapid decrease in phosphorylated Akt and phosphorylated p27, concomitant with an increase in nuclear p27.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	cyclin-dependent kinase inhibitor 1B	Mus musculus	201-204
19859997-8	2009	CONCLUSION: The class I PI3K inhibitor LY294002 could inhibit the invasiveness of gastric cancer cells by downregulating the expression of MMP-2, MMP-9, and VEGF, and reducing MVD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	matrix metallopeptidase 9	Homo sapiens	146-151
19859997-8	2009	CONCLUSION: The class I PI3K inhibitor LY294002 could inhibit the invasiveness of gastric cancer cells by downregulating the expression of MMP-2, MMP-9, and VEGF, and reducing MVD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	vascular endothelial growth factor A	Homo sapiens	157-161
19648963-8	2009	Treatment of lung tumor-bearing mice with the phosphoinositol-3 kinase inhibitor LY294002 induced a rapid decrease in phosphorylated Akt and phosphorylated p27, concomitant with an increase in nuclear p27.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	thymoma viral proto-oncogene 1	Mus musculus	133-136
19648963-8	2009	Treatment of lung tumor-bearing mice with the phosphoinositol-3 kinase inhibitor LY294002 induced a rapid decrease in phosphorylated Akt and phosphorylated p27, concomitant with an increase in nuclear p27.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	cyclin-dependent kinase inhibitor 1B	Mus musculus	156-159
19625607-4	2009	The activating effect of H-rasQ61L on both MHC promoters after 4 days of differentiation was significantly reduced by LY-294002, a specific inhibitor of the phosphoinositol-3-kinase (PI3K), a downstream target of Ras.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-127	PBV1SPCR2	Oryctolagus cuniculus	43-46
19653997-6	2009	PDGF-induced Muller cell proliferation was significantly reduced by pre-treatment with SP600125 and LY294002, inhibitors of c-JNK and Akt phosphorylation, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	AKT serine/threonine kinase 1	Homo sapiens	134-137
20079140-12	2009	The anti-apoptotic effect of apelin-13 was blocked by LY294002 (P &lt; 0.01) but not by rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	apelin	Rattus norvegicus	29-35
19625610-4	2009	Especially, phosphorylation of caveolin-1 is attenuated by AG1478, herbimycin A (tyrosine kinase inhibitors), and pyrazolopyrimidine 2 (PP2, Src inhibitor) and EGF-induced ERK activation was blocked by PP2, methyl-beta-cyclodextrin (MbetaCD), caveolin-1 small interfering RNA (siRNA), LY-294002 [phosphoinositol-3 kinase inhibitor (PI3K)], and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	285-294	caveolin 1, caveolae protein	Mus musculus	31-41
19657059-6	2009	To identify potential IGF-I signaling molecules, the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY-294002 were both found to markedly attenuate IGF-I activation of the 1.3-kb type IIb MyHC promoter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-125	insulin-like growth factor 1	Mus musculus	22-27
19625610-4	2009	Especially, phosphorylation of caveolin-1 is attenuated by AG1478, herbimycin A (tyrosine kinase inhibitors), and pyrazolopyrimidine 2 (PP2, Src inhibitor) and EGF-induced ERK activation was blocked by PP2, methyl-beta-cyclodextrin (MbetaCD), caveolin-1 small interfering RNA (siRNA), LY-294002 [phosphoinositol-3 kinase inhibitor (PI3K)], and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	285-294	epidermal growth factor	Mus musculus	160-163
19625610-5	2009	In addition, EGF promoted the cell migration, which was attenuated by PP2, caveolin-1 siRNA, FAK siRNA, LY-294002, Akt inhibitor, and PD-98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-113	epidermal growth factor	Mus musculus	13-16
19625610-6	2009	EGF also increased matrix metalloproteinase (MMP-2) expression levels and EGF-induced MMP2 expression was inhibited by caveolin-1 siRNA, FAK siRNA, LY-294002, Akt inhibitor, and PD-98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-157	epidermal growth factor	Mus musculus	0-3
19625610-6	2009	EGF also increased matrix metalloproteinase (MMP-2) expression levels and EGF-induced MMP2 expression was inhibited by caveolin-1 siRNA, FAK siRNA, LY-294002, Akt inhibitor, and PD-98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-157	epidermal growth factor	Mus musculus	74-77
19625610-6	2009	EGF also increased matrix metalloproteinase (MMP-2) expression levels and EGF-induced MMP2 expression was inhibited by caveolin-1 siRNA, FAK siRNA, LY-294002, Akt inhibitor, and PD-98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-157	matrix metallopeptidase 2	Mus musculus	86-90
19625610-8	2009	EGF also significantly increases [(3)H]thymidine incorporation and cell number, which were significantly blocked by AG 1478, PP2, MbetaCD, caveolin-1 siRNA, FAK siRNA, LY-294002, and PD-98059 (ERK inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-177	epidermal growth factor	Mus musculus	0-3
19588205-10	2009	Levels of active, phosphorylated Akt and the NE tumor markers, ASCL1 and CgA, were diminished with both LY294002 and Akt1 siRNA treatments proportional to the degree of Akt inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	AKT serine/threonine kinase 1	Homo sapiens	33-36
19588205-10	2009	Levels of active, phosphorylated Akt and the NE tumor markers, ASCL1 and CgA, were diminished with both LY294002 and Akt1 siRNA treatments proportional to the degree of Akt inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	achaete-scute family bHLH transcription factor 1	Homo sapiens	63-68
19588205-10	2009	Levels of active, phosphorylated Akt and the NE tumor markers, ASCL1 and CgA, were diminished with both LY294002 and Akt1 siRNA treatments proportional to the degree of Akt inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	chromogranin A	Homo sapiens	73-76
19641096-8	2009	Both LY-294002 (100 microM), an inhibitor of PI3 kinases, and its inactive analog LY-303511 (100 microM) rapidly and reversibly inhibited Kir current, suggesting that these compounds act as direct channel blockers.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-14	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	138-141
19644051-11	2009	Inhibition of Akt phosphorylation with LY294002 abolished hypoxia-induced GSK-3beta inactivation, beta-catenin activation, and MMP-7 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	14-17
19644051-11	2009	Inhibition of Akt phosphorylation with LY294002 abolished hypoxia-induced GSK-3beta inactivation, beta-catenin activation, and MMP-7 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	glycogen synthase kinase 3 beta	Homo sapiens	74-83
19644051-11	2009	Inhibition of Akt phosphorylation with LY294002 abolished hypoxia-induced GSK-3beta inactivation, beta-catenin activation, and MMP-7 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	catenin beta 1	Homo sapiens	98-110
19644051-11	2009	Inhibition of Akt phosphorylation with LY294002 abolished hypoxia-induced GSK-3beta inactivation, beta-catenin activation, and MMP-7 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	matrix metallopeptidase 7	Homo sapiens	127-132
19657059-6	2009	To identify potential IGF-I signaling molecules, the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY-294002 were both found to markedly attenuate IGF-I activation of the 1.3-kb type IIb MyHC promoter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-125	insulin-like growth factor 1	Mus musculus	164-169
19657059-6	2009	To identify potential IGF-I signaling molecules, the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY-294002 were both found to markedly attenuate IGF-I activation of the 1.3-kb type IIb MyHC promoter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-125	myosin heavy chain, cardiac muscle complex	Mus musculus	204-208
19638627-6	2009	Further, a PI3-kinase inhibitor, LY294002, and cytosine arabinoside synergized in antileukemia effects on Meg-01 and primary pediatric AMkL cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	106-109
19785652-9	2009	The mTOR inhibitor LY294002, like rapamycin, decreased IP(3)-evoked Ca(2+) release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	mechanistic target of rapamycin kinase	Homo sapiens	4-8
19443725-7	2009	In contrast, blocking PI3-K activation with LY294002 (50 microM) eliminated EGF-induced GSK-3 inhibition and Erk1/2 phosphorylation as well as increases in proliferation and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	peptidase inhibitor 3	Homo sapiens	22-25
19443725-7	2009	In contrast, blocking PI3-K activation with LY294002 (50 microM) eliminated EGF-induced GSK-3 inhibition and Erk1/2 phosphorylation as well as increases in proliferation and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	epidermal growth factor	Homo sapiens	76-79
19443725-7	2009	In contrast, blocking PI3-K activation with LY294002 (50 microM) eliminated EGF-induced GSK-3 inhibition and Erk1/2 phosphorylation as well as increases in proliferation and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	mitogen-activated protein kinase 3	Homo sapiens	109-115
19443725-9	2009	Inhibition of EGF-induced increases in proliferation and migration by LY294002 was associated with sustained MKP-1 phosphorylation induced by GSK-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	epidermal growth factor	Homo sapiens	14-17
19443725-9	2009	Inhibition of EGF-induced increases in proliferation and migration by LY294002 was associated with sustained MKP-1 phosphorylation induced by GSK-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	dual specificity phosphatase 1	Homo sapiens	109-114
19443725-10	2009	Prolonging MKP-1 phosphorylation by LY294002 increased p27Kip1, whereas cyclin D1 levels fell.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	dual specificity phosphatase 1	Homo sapiens	11-16
19443725-10	2009	Prolonging MKP-1 phosphorylation by LY294002 increased p27Kip1, whereas cyclin D1 levels fell.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	cyclin dependent kinase inhibitor 1B	Homo sapiens	55-62
19656856-8	2009	The phosphoinositide 3-kinase inhibitors, LY294002 and the mammalian target of rapamycin inhibitor rapamycin, abolished the IL-1Ra induction by 9E,11E-CLA, whereas other kinase inhibitors did not affect this response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	interleukin 1 receptor antagonist	Homo sapiens	124-130
19717011-5	2009	YC-1-mediated Raf-1 activation was inhibited by an sGC inhibitor (ODQ), a PKG inhibitor (KT-5823), a Ras inhibitor (manumycin A), a dominant negative Ras mutant (RasN17), a protein kinase C-alpha (PKC-alpha) inhibitor (Ro 32-0432), and a phosphoinositide-3-OH-kinase (PI3K) inhibitor (LY 294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	285-294	RNA binding motif single stranded interacting protein 1	Homo sapiens	0-4
19717011-5	2009	YC-1-mediated Raf-1 activation was inhibited by an sGC inhibitor (ODQ), a PKG inhibitor (KT-5823), a Ras inhibitor (manumycin A), a dominant negative Ras mutant (RasN17), a protein kinase C-alpha (PKC-alpha) inhibitor (Ro 32-0432), and a phosphoinositide-3-OH-kinase (PI3K) inhibitor (LY 294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	285-294	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-19
19492417-4	2009	All these EGF effects were significantly blocked when HT-29 cells were treated with an inhibitor of the phosphoinositide 3-kinase (PI3K) pathway, LY294002, or with small interfering RNA (siRNA) targeting STAT3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	epidermal growth factor	Homo sapiens	10-13
19507191-6	2009	PKR inhibition augmented levels of p-S473 AKT and p-S21/9 GSK-3alpha/beta in the presence of the PI3K inhibitor, LY294002, but was unable to augment GSK-3alpha or beta phosphorylation in the presence of the AKT inhibitor, A443654.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	0-3
19507191-6	2009	PKR inhibition augmented levels of p-S473 AKT and p-S21/9 GSK-3alpha/beta in the presence of the PI3K inhibitor, LY294002, but was unable to augment GSK-3alpha or beta phosphorylation in the presence of the AKT inhibitor, A443654.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Homo sapiens	42-45
19507191-6	2009	PKR inhibition augmented levels of p-S473 AKT and p-S21/9 GSK-3alpha/beta in the presence of the PI3K inhibitor, LY294002, but was unable to augment GSK-3alpha or beta phosphorylation in the presence of the AKT inhibitor, A443654.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	protein S	Homo sapiens	50-57
19507191-6	2009	PKR inhibition augmented levels of p-S473 AKT and p-S21/9 GSK-3alpha/beta in the presence of the PI3K inhibitor, LY294002, but was unable to augment GSK-3alpha or beta phosphorylation in the presence of the AKT inhibitor, A443654.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	glycogen synthase kinase 3 alpha	Homo sapiens	58-68
19507191-7	2009	Pre-treatment with the PKR inhibitor blocked the ability of A443654 and LY294002 to promote phosphorylation of eIF2alpha, indicating the mechanism leading to AKT phosphorylation and activation did not require eIF2alpha phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	23-26
19507191-7	2009	Pre-treatment with the PKR inhibitor blocked the ability of A443654 and LY294002 to promote phosphorylation of eIF2alpha, indicating the mechanism leading to AKT phosphorylation and activation did not require eIF2alpha phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	eukaryotic translation initiation factor 2A	Homo sapiens	111-120
19507191-7	2009	Pre-treatment with the PKR inhibitor blocked the ability of A443654 and LY294002 to promote phosphorylation of eIF2alpha, indicating the mechanism leading to AKT phosphorylation and activation did not require eIF2alpha phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	158-161
19595723-2	2009	Phosphorylation of Akt occurs early during JUNV infection of Vero cells and is blocked by the PI3K inhibitor, Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Homo sapiens	19-22
19595723-5	2009	Inhibition of Akt phosphorylation by Ly294002 impaired viral protein synthesis and expression leading to a reduced infectious virus yield without blocking the onset of persistent stage of infection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	14-17
19775474-9	2009	Testosterone induced ERK and Akt phosphorylation, which could be abrogated by ER-alpha 36 shRNA knockdown or the kinase inhibitors, U0126 and LY294002, and the aromatase inhibitor letrozole.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	mitogen-activated protein kinase 1	Homo sapiens	21-24
19775474-9	2009	Testosterone induced ERK and Akt phosphorylation, which could be abrogated by ER-alpha 36 shRNA knockdown or the kinase inhibitors, U0126 and LY294002, and the aromatase inhibitor letrozole.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	AKT serine/threonine kinase 1	Homo sapiens	29-32
19535511-6	2009	Forskolin and 8-Br-cGMP induced CFTR phosphorylation and shifted CFTR proteins to the plasma membrane of duodenal epithelial cells, which were inhibited by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	cystic fibrosis transmembrane conductance regulator	Mus musculus	32-36
19764090-11	2009	However, the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	heme oxygenase 1	Mus musculus	109-113
19764090-12	2009	CONCLUSION: Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	heme oxygenase 1	Mus musculus	26-30
19738051-9	2009	Pharmacologic inhibition of Akt with LY294002 abrogated insulin- or serum-induced eEF1A2 expression and increased the caspase-3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	28-31
19738051-9	2009	Pharmacologic inhibition of Akt with LY294002 abrogated insulin- or serum-induced eEF1A2 expression and increased the caspase-3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	insulin	Homo sapiens	56-64
19738051-9	2009	Pharmacologic inhibition of Akt with LY294002 abrogated insulin- or serum-induced eEF1A2 expression and increased the caspase-3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	82-88
19738051-9	2009	Pharmacologic inhibition of Akt with LY294002 abrogated insulin- or serum-induced eEF1A2 expression and increased the caspase-3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	caspase 3	Homo sapiens	118-127
19577623-5	2009	Both GA-induced NO production and eNOS activation were attenuated by pretreatment of the cells with EGTA, an extracellular Ca(2+) chelator, and BAPTA-AM, an intracellular Ca(2+) chelator, but not by LY 294002, a PI3-kinase/Akt inhibitor, suggesting involvement of Ca(2+).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-208	nitric oxide synthase 3	Homo sapiens	34-38
19946410-5	2009	The PI3K/Akt signaling pathway is necessary for mesenchyme outgrowth, as sprouting was inhibited in AVC explant cultures treated with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	AKT serine/threonine kinase 1	Homo sapiens	9-12
19463904-10	2009	Inhibitors of PI3K (LY294002), Akt (Akt-I), and mTOR (rapamycin) reduced the GLP-1-induced GCLc upregulation and its protection against MG-induced PC12 apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	glucagon	Rattus norvegicus	77-82
19463904-10	2009	Inhibitors of PI3K (LY294002), Akt (Akt-I), and mTOR (rapamycin) reduced the GLP-1-induced GCLc upregulation and its protection against MG-induced PC12 apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	91-95
19617352-6	2009	Dexamethasone-activated DeltaF508-CFTR rescue is blocked either by the glucocorticoid receptor antagonist RU38486 or by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	CF transmembrane conductance regulator	Homo sapiens	34-38
19535511-6	2009	Forskolin and 8-Br-cGMP induced CFTR phosphorylation and shifted CFTR proteins to the plasma membrane of duodenal epithelial cells, which were inhibited by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	cystic fibrosis transmembrane conductance regulator	Mus musculus	65-69
19535511-7	2009	Forskolin and 8-Br-cGMP not only increased the activity of PI3K but also induced the phosphorylation of Akt, a signaling molecule downstream of PI3K, which were again inhibited by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	thymoma viral proto-oncogene 1	Mus musculus	104-107
19634012-9	2009	The cytoprotection of IMD(1-53) was abolished with LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	adrenomedullin 2	Rattus norvegicus	22-25
19661440-7	2009	Finally, in the presence of either the phosphatidylinositol 3 kinase inhibitor LY294002 or the inflammatory cytokine interferon-gamma, LPS activates both caspase- and Cat B-dependent death pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	cathepsin B	Homo sapiens	167-172
19676073-7	2009	The latter was blocked by PP2, rapamycin or LY294002, but not by Wortmannin, whereas phosphorylation of Akt was blocked by LY294002 or Wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	thymoma viral proto-oncogene 1	Mus musculus	104-107
19656152-3	2009	The PI-3K pathway promoted differentiation of interleukin-3 (IL-3)-stimulated myelopoiesis via Akt, because inhibition of the PI-3K/Akt pathway with LY294002 or SH-5 increased proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	interleukin 3	Homo sapiens	46-59
19656152-3	2009	The PI-3K pathway promoted differentiation of interleukin-3 (IL-3)-stimulated myelopoiesis via Akt, because inhibition of the PI-3K/Akt pathway with LY294002 or SH-5 increased proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	interleukin 3	Homo sapiens	61-65
19656152-3	2009	The PI-3K pathway promoted differentiation of interleukin-3 (IL-3)-stimulated myelopoiesis via Akt, because inhibition of the PI-3K/Akt pathway with LY294002 or SH-5 increased proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	AKT serine/threonine kinase 1	Homo sapiens	132-135
19656152-7	2009	Surprisingly, the addition of Dkk-1 to LY294002 or SH-5 blocked their proliferative effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	30-35
19475567-5	2009	On the other hand, the phosphoinositide 3-kinase inhibitor, LY294002, abolished IGF-I-induced dephosphorylation, translocation of MARCKS to lipid rafts, and lamellipodia formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	insulin like growth factor 1	Homo sapiens	80-85
19475567-5	2009	On the other hand, the phosphoinositide 3-kinase inhibitor, LY294002, abolished IGF-I-induced dephosphorylation, translocation of MARCKS to lipid rafts, and lamellipodia formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	myristoylated alanine rich protein kinase C substrate	Homo sapiens	130-136
20196785-5	2009	However, the cardioprotective properties of E(2), BSA-E(2) and ERalpha overexpression to inhibit LPS-induced apoptosis and promote cell survival were attenuated by applying LY294002 (PI3K inhibitor) and PI3K siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	estrogen receptor 1	Homo sapiens	63-70
19520771-9	2009	Finally, we demonstrated that the PI3K inhibitor LY294002 blocked the induction of PACE4 mRNA, a result not observed when another myogenic differentiation inhibitor, SB203580 (p38 MAP kinase inhibitor), was employed, indicating the presence of a positive feedback loop regulating PACE4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	proprotein convertase subtilisin/kexin type 6	Mus musculus	83-88
19520771-9	2009	Finally, we demonstrated that the PI3K inhibitor LY294002 blocked the induction of PACE4 mRNA, a result not observed when another myogenic differentiation inhibitor, SB203580 (p38 MAP kinase inhibitor), was employed, indicating the presence of a positive feedback loop regulating PACE4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mitogen-activated protein kinase 14	Mus musculus	176-179
19520771-9	2009	Finally, we demonstrated that the PI3K inhibitor LY294002 blocked the induction of PACE4 mRNA, a result not observed when another myogenic differentiation inhibitor, SB203580 (p38 MAP kinase inhibitor), was employed, indicating the presence of a positive feedback loop regulating PACE4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	proprotein convertase subtilisin/kexin type 6	Mus musculus	280-285
19723872-7	2009	Interestingly, inhibition of PI3K with LY294002 or by small interfering RNA-mediated knockdown of PI3K p85 or p110 subunits also clearly attenuated JNK activation and cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	mitogen-activated protein kinase 8	Homo sapiens	148-151
19735104-6	2009	While one phosphoinositide 3-kinases (PI-3) kinase inhibitor, LY294002, completely blocked the effect of TGF-beta1 on SHARP-2 mRNA expression in LLC-PK1 cells at a low concentration, other inhibitors, including PD98059, staurosporine, AG490, wortmannin, okadaic acid and rapamycin, had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	transforming growth factor beta 1	Sus scrofa	105-114
19559571-10	2009	The HB-EGF-induced eNOS activation was significantly blocked by the p42/p44 MAPK inhibitor U0126 and the phosphatidylinositol 3-kinase (P13K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	heparin binding EGF like growth factor	Homo sapiens	4-10
19559571-12	2009	The HB-EGF-induced VEGF production was blocked by U0126 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	heparin binding EGF like growth factor	Homo sapiens	4-10
19559571-12	2009	The HB-EGF-induced VEGF production was blocked by U0126 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	vascular endothelial growth factor A	Homo sapiens	19-23
19639199-8	2009	Moreover, LY294002 treatment of BMP2-sensitive SW480 cells blocked cell growth and enhanced motility and invasiveness.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	bone morphogenetic protein 2	Homo sapiens	32-36
19381068-7	2009	Finally, pretreatment of rat aortic ring with LY294002 and nifedipine significantly reduced AngII-induced constriction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	angiotensinogen	Rattus norvegicus	92-97
19497060-9	2009	PLTs incubated for 7 days with the PI3-kinase inhibitor LY294002 showed diminished Rap1 activation as well as a moderate reduction in integrin alphaIIbbeta3 activation and release of alpha-granules.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	peptidase inhibitor 3	Homo sapiens	35-38
19497060-9	2009	PLTs incubated for 7 days with the PI3-kinase inhibitor LY294002 showed diminished Rap1 activation as well as a moderate reduction in integrin alphaIIbbeta3 activation and release of alpha-granules.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	RAP1A, member of RAS oncogene family	Homo sapiens	83-87
19381068-4	2009	AngII-induced collagen gel contraction was blocked by pretreatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) whereas ERK inhibitor (PD98059) was not effective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	angiotensinogen	Rattus norvegicus	0-5
19427341-4	2009	HCMV-infected monocytes treated with Bay11-7802 (an inhibitor of NF-kappaB activity) or LY294002 [an inhibitor of PI(3)K activity] prior to infection exhibited a small, round and monocyte-like undifferentiated morphology and the lack of CD68 upregulation (a macrophage differentiation marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	CD68 molecule	Homo sapiens	237-241
19515017-6	2009	Low phospho-Akt and corresponding low phospho-GSK-3 (glycogen synthase kinase-3) and high phospho-Pten levels accompany wortmannin or LY294002 treatment, which inhibit PI3K activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	glycogen synthase kinase 3 beta, genome duplicate a	Danio rerio	46-51
19381068-4	2009	AngII-induced collagen gel contraction was blocked by pretreatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) whereas ERK inhibitor (PD98059) was not effective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	74-103
19515017-6	2009	Low phospho-Akt and corresponding low phospho-GSK-3 (glycogen synthase kinase-3) and high phospho-Pten levels accompany wortmannin or LY294002 treatment, which inhibit PI3K activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	phosphatase and tensin homolog B	Danio rerio	98-102
19469902-5	2009	The suppressive activity of PPC on alpha-MSH-induced melanogenesis was abrogated by selective inhibition of MEK/ERK (PD98059) and PI3K (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	pro-opiomelanocortin-alpha	Mus musculus	35-44
19654299-3	2009	Here, we explore the potential link between nicotine and PPARbeta/delta and report that nicotine increases the expression of PPARbeta/delta protein; this effect was blocked by an alpha7 nAChR antagonist (alpha-bungarotoxin), by alpha7 nAChR short interfering RNA, and by inhibitors of phosphatidylinositol 3-kinase (PI3K; wortmannin and LY294002) and mammalian target of rapamycin (mTOR; rapamycin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	337-345	peroxisome proliferator activated receptor delta	Homo sapiens	125-133
19635908-8	2009	PGN mediated an increase in the accumulation of phosphorylated c-Jun in the nucleus, AP-1-luciferase activity, and c-Jun binding to AP-1 element was inhibited by Ly294002, Akt inhibitor, and FAK mutant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-68
19635908-8	2009	PGN mediated an increase in the accumulation of phosphorylated c-Jun in the nucleus, AP-1-luciferase activity, and c-Jun binding to AP-1 element was inhibited by Ly294002, Akt inhibitor, and FAK mutant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	115-120
19635908-8	2009	PGN mediated an increase in the accumulation of phosphorylated c-Jun in the nucleus, AP-1-luciferase activity, and c-Jun binding to AP-1 element was inhibited by Ly294002, Akt inhibitor, and FAK mutant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	protein tyrosine kinase 2	Homo sapiens	191-194
19531636-8	2009	The phosphatidylinositol 3-kinase inhibitor LY-294002 significantly blunted the increase of NOS activity and NO level induced by SHH treatment in human umbilican vein endothelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-53	sonic hedgehog signaling molecule	Homo sapiens	129-132
19661304-6	2009	Interestingly, single cell migration was stimulated upon blocking phosphatidylinositol 3-kinase (PI3K) and also p38-MAPK by treatment with LY294002 and SB203580 respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	mitogen-activated protein kinase 14	Homo sapiens	112-115
19556857-5	2009	Next, we demonstrated that insulin acts on the PI3K-Akt-mTOR pathway to promote necrosis as the suppression of the above pathway by either chemical inhibitors (LY294002 and rapamycin) or mTOR knockdown is able to mitigate the pro-death function of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	mechanistic target of rapamycin kinase	Mus musculus	56-60
19406941-5	2009	Using selective inhibitors of ERK1/2 (UO126) or Akt phosphorylation (LY294002), we show that the ERK1/2 and Akt cascades are both involved in the hCG- and EGF-dependent proliferation of Leydig cells, but only the ERK1/2 cascade is involved in their antiapoptotic actions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	48-51
19406941-5	2009	Using selective inhibitors of ERK1/2 (UO126) or Akt phosphorylation (LY294002), we show that the ERK1/2 and Akt cascades are both involved in the hCG- and EGF-dependent proliferation of Leydig cells, but only the ERK1/2 cascade is involved in their antiapoptotic actions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	mitogen-activated protein kinase 3	Homo sapiens	97-103
19406941-5	2009	Using selective inhibitors of ERK1/2 (UO126) or Akt phosphorylation (LY294002), we show that the ERK1/2 and Akt cascades are both involved in the hCG- and EGF-dependent proliferation of Leydig cells, but only the ERK1/2 cascade is involved in their antiapoptotic actions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	108-111
19406941-5	2009	Using selective inhibitors of ERK1/2 (UO126) or Akt phosphorylation (LY294002), we show that the ERK1/2 and Akt cascades are both involved in the hCG- and EGF-dependent proliferation of Leydig cells, but only the ERK1/2 cascade is involved in their antiapoptotic actions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	epidermal growth factor	Homo sapiens	155-158
19406941-5	2009	Using selective inhibitors of ERK1/2 (UO126) or Akt phosphorylation (LY294002), we show that the ERK1/2 and Akt cascades are both involved in the hCG- and EGF-dependent proliferation of Leydig cells, but only the ERK1/2 cascade is involved in their antiapoptotic actions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	mitogen-activated protein kinase 3	Homo sapiens	97-103
19139893-12	2009	In addition, we found that PI3K/AKT pathway was activated; Ly294002, a PI3K/AKT specific inhibitor, can enhance the anti-leukemic effect of casticin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	76-79
19207715-12	2009	LY294002 abolished the IPoC-induced phosphorylation of Akt and GSK-3beta, as well as the infarct-limiting effect of IPoC in adult and aged rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	55-58
19207715-12	2009	LY294002 abolished the IPoC-induced phosphorylation of Akt and GSK-3beta, as well as the infarct-limiting effect of IPoC in adult and aged rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	63-72
19472407-7	2009	Cells with single activation of ERBB2, PTEN, or MET signaling showed greater sensitivity to cell-growth inhibition induced by erlotinib, LY294002, and PHA665752, respectively, than did cells featuring simultaneous activation of these pathways, underlining the need for combined therapeutic strategies in targeted cancer treatments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	erb-b2 receptor tyrosine kinase 2	Homo sapiens	32-37
19472407-7	2009	Cells with single activation of ERBB2, PTEN, or MET signaling showed greater sensitivity to cell-growth inhibition induced by erlotinib, LY294002, and PHA665752, respectively, than did cells featuring simultaneous activation of these pathways, underlining the need for combined therapeutic strategies in targeted cancer treatments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	phosphatase and tensin homolog	Homo sapiens	39-43
18829283-9	2009	In contrast, inhibition of phosphatidylinositol 3-kinase (PI3K) with LY294002 resulted in a 1.6-fold significant increase in the nVDR activity in the ras cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	27-56
19415692-3	2009	The CHIT-1 induction PRL-mediated was reduced by wortmannin and LY-294002, inhibitors of phosphatidylinositol 3-kinase (PI3-K) and by genistein an inhibitor of protein tyrosine kinase (PTK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	chitinase 1	Homo sapiens	4-10
19415692-3	2009	The CHIT-1 induction PRL-mediated was reduced by wortmannin and LY-294002, inhibitors of phosphatidylinositol 3-kinase (PI3-K) and by genistein an inhibitor of protein tyrosine kinase (PTK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	prolactin	Homo sapiens	21-24
19415692-3	2009	The CHIT-1 induction PRL-mediated was reduced by wortmannin and LY-294002, inhibitors of phosphatidylinositol 3-kinase (PI3-K) and by genistein an inhibitor of protein tyrosine kinase (PTK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	protein tyrosine kinase 2 beta	Homo sapiens	185-188
19393774-10	2009	Application of PI3K inhibitors, wortmannin and LY294002 attenuated the depression of TNF-alpha and iNOS expression by amlodipine in LPS-induced cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	tumor necrosis factor	Rattus norvegicus	85-94
19393774-10	2009	Application of PI3K inhibitors, wortmannin and LY294002 attenuated the depression of TNF-alpha and iNOS expression by amlodipine in LPS-induced cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	nitric oxide synthase 2	Rattus norvegicus	99-103
19415692-6	2009	In addition, PRL induced a phosphorylation of AKT that was prevented both by the two MAPK inhibitors SB203580 and U0126 and by the PI3-K inhibitors wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-172	prolactin	Homo sapiens	13-16
19415692-6	2009	In addition, PRL induced a phosphorylation of AKT that was prevented both by the two MAPK inhibitors SB203580 and U0126 and by the PI3-K inhibitors wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-172	AKT serine/threonine kinase 1	Homo sapiens	46-49
19454653-6	2009	We show that anti-sIgM antibody and PI3K inhibitor LY294002-induced apoptosis are reduced significantly in CEACAM1 knock-down clones compared with WT Daudi cells and that anti-sIgM treatment induced CEACAM1 tyrosine phosphorylation and association with SHP-1 in WT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	CEA cell adhesion molecule 1	Homo sapiens	107-114
19454653-6	2009	We show that anti-sIgM antibody and PI3K inhibitor LY294002-induced apoptosis are reduced significantly in CEACAM1 knock-down clones compared with WT Daudi cells and that anti-sIgM treatment induced CEACAM1 tyrosine phosphorylation and association with SHP-1 in WT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	CEA cell adhesion molecule 1	Homo sapiens	199-206
19454653-6	2009	We show that anti-sIgM antibody and PI3K inhibitor LY294002-induced apoptosis are reduced significantly in CEACAM1 knock-down clones compared with WT Daudi cells and that anti-sIgM treatment induced CEACAM1 tyrosine phosphorylation and association with SHP-1 in WT cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	nuclear receptor subfamily 0 group B member 2	Homo sapiens	253-258
19533041-7	2009	LY294002 treatment abrogated Lf(Fe(3+))-induced Akt activation, and prevented the cytoplasmic localization of p27(kip1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	48-51
19625496-11	2009	The protective effect of Hsp27 against HTI-286 was suppressed by LY294002, a phosphatidylinositol 3-kinase inhibitor, indicating that Hsp27-Akt interactions are key mechanisms to enhance chemosensitivity via OGX427.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	heat shock protein family B (small) member 1	Homo sapiens	25-30
19483102-6	2009	The putative phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 was found to reduce basal and PAR-stimulated PIP(2) levels by mass spectrometry and to inhibit PAR1-mediated stable platelet aggregation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	prolactin induced protein	Homo sapiens	114-117
19483102-6	2009	The putative phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 was found to reduce basal and PAR-stimulated PIP(2) levels by mass spectrometry and to inhibit PAR1-mediated stable platelet aggregation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	coagulation factor II thrombin receptor	Homo sapiens	164-168
19533041-7	2009	LY294002 treatment abrogated Lf(Fe(3+))-induced Akt activation, and prevented the cytoplasmic localization of p27(kip1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	dynactin subunit 6	Homo sapiens	110-113
19533041-7	2009	LY294002 treatment abrogated Lf(Fe(3+))-induced Akt activation, and prevented the cytoplasmic localization of p27(kip1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	114-118
19568240-11	2009	The PI3K inhibitor, LY294002, further blocked the expression of MMP9 and RhoA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	matrix metallopeptidase 9	Homo sapiens	64-68
19711039-6	2009	This bFGF-induced [Mg(2+)](i) increase was blocked by tyrosine kinase inhibitors (tyrphostin A-23 and genistein), phosphatidylinositol 3-kinase (PI3K) inhibitors (wortmannin and LY294002) and a phospholipase Cgamma (PLCgamma) inhibitor (U73122).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	fibroblast growth factor 2	Homo sapiens	5-9
19568240-11	2009	The PI3K inhibitor, LY294002, further blocked the expression of MMP9 and RhoA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	ras homolog family member A	Homo sapiens	73-77
19610136-8	2009	Inhibition of PI3K with LY294002 suppressed extracellular signal-regulated kinase-1 and -2 (ERK1/2) activation in BxPC-3, but enhanced ERK1/2 activation in PANC-1 cells that express IGFBP-5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	mitogen-activated protein kinase 1	Homo sapiens	44-90
19610136-8	2009	Inhibition of PI3K with LY294002 suppressed extracellular signal-regulated kinase-1 and -2 (ERK1/2) activation in BxPC-3, but enhanced ERK1/2 activation in PANC-1 cells that express IGFBP-5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	mitogen-activated protein kinase 3	Homo sapiens	92-98
19269083-4	2009	Inhibition of Akt kinase activation by a PI3K inhibitor LY294002, or exogenous expression of a kinase-dead mutant of Akt abrogated the increase of Snail expression induced by HRG-beta1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	14-17
19473970-7	2009	Hypoxia leads to FOXO3a phosphorylation at an Akt/protein kinase B target site and subsequent nuclear export; these processes are reversed by reoxygenation and blocked by LY294002, a phosphatidylinositol 3-kinase inhibitor that blocks Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	forkhead box O3	Homo sapiens	17-23
19473970-7	2009	Hypoxia leads to FOXO3a phosphorylation at an Akt/protein kinase B target site and subsequent nuclear export; these processes are reversed by reoxygenation and blocked by LY294002, a phosphatidylinositol 3-kinase inhibitor that blocks Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	protein tyrosine kinase 2 beta	Homo sapiens	50-66
19473970-7	2009	Hypoxia leads to FOXO3a phosphorylation at an Akt/protein kinase B target site and subsequent nuclear export; these processes are reversed by reoxygenation and blocked by LY294002, a phosphatidylinositol 3-kinase inhibitor that blocks Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	AKT serine/threonine kinase 1	Homo sapiens	235-238
19473970-8	2009	LY294002 also prevents the hypoxia-mediated decrease in TNFR2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	TNF receptor superfamily member 1B	Homo sapiens	56-61
19420107-3	2009	Only transforming growth factor-beta (TGF-beta) significantly increased MCP-1 production, which was prevented by SB431542 and LY294002, indicating that signaling proceeded through the TGF-beta type I receptor kinase and the phosphatidylinositol 3-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	chemokine (C-C motif) ligand 2	Mus musculus	72-77
19362548-5	2009	Further studies with Wortmannin and LY294002 revealed that phophoinositol-3-kinase (PI3K) plays a central role in opioid-induced Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	59-82
19362548-5	2009	Further studies with Wortmannin and LY294002 revealed that phophoinositol-3-kinase (PI3K) plays a central role in opioid-induced Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	thymoma viral proto-oncogene 1	Mus musculus	129-132
19571375-8	2009	The Akt inhibitor LY294002 synergistically potentiated paeonol-induced inactivation of Akt and vascular endothelial growth factor in bFGF-treated HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	4-7
19435852-5	2009	Moreover, the effect of intra-VTA leptin administration to reduce 4- and 20-h food intake and 20-h body weight was blocked by an inhibitor of Jak-2, at a dose that had no effect on food intake or body weight by itself, but not by local inhibition of either PI 3-kinase (LY-294002) or mTOR (rapamycin) in this timeframe.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	270-279	leptin	Homo sapiens	34-40
19435852-5	2009	Moreover, the effect of intra-VTA leptin administration to reduce 4- and 20-h food intake and 20-h body weight was blocked by an inhibitor of Jak-2, at a dose that had no effect on food intake or body weight by itself, but not by local inhibition of either PI 3-kinase (LY-294002) or mTOR (rapamycin) in this timeframe.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	270-279	Janus kinase 2	Homo sapiens	142-147
19166999-6	2009	We also studied the involvement of PI3Kinase, MAPKinase and NF-kappaB pathways in visfatin induced MCP-1/CCR2 levels by employing LY294002, U0126 and BAY11-7085, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	nicotinamide phosphoribosyltransferase	Homo sapiens	82-90
19166999-7	2009	We found the increase in MCP-1 and CCR2 levels by visfatin were negated by LY294002 and BAY11-7085, but not with U0126, suggesting the crucial role of PI3Kinase and NF-kappaB pathways in visfatin induced MCP-1 and its autocrine regulation via the CCR2 receptor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	C-C motif chemokine ligand 2	Homo sapiens	25-30
19166999-7	2009	We found the increase in MCP-1 and CCR2 levels by visfatin were negated by LY294002 and BAY11-7085, but not with U0126, suggesting the crucial role of PI3Kinase and NF-kappaB pathways in visfatin induced MCP-1 and its autocrine regulation via the CCR2 receptor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	C-C motif chemokine receptor 2	Homo sapiens	35-39
19166999-7	2009	We found the increase in MCP-1 and CCR2 levels by visfatin were negated by LY294002 and BAY11-7085, but not with U0126, suggesting the crucial role of PI3Kinase and NF-kappaB pathways in visfatin induced MCP-1 and its autocrine regulation via the CCR2 receptor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	nicotinamide phosphoribosyltransferase	Homo sapiens	50-58
19108833-6	2009	The activation of mTOR signaling by oxLDL, requires the upstream activation of PI3K and Akt, as assessed by the inhibitory effect of the PI3K inhibitor Ly294002 on mTOR activation and DNA synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	mechanistic target of rapamycin kinase	Homo sapiens	18-22
19108833-6	2009	The activation of mTOR signaling by oxLDL, requires the upstream activation of PI3K and Akt, as assessed by the inhibitory effect of the PI3K inhibitor Ly294002 on mTOR activation and DNA synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	AKT serine/threonine kinase 1	Homo sapiens	88-91
19108833-6	2009	The activation of mTOR signaling by oxLDL, requires the upstream activation of PI3K and Akt, as assessed by the inhibitory effect of the PI3K inhibitor Ly294002 on mTOR activation and DNA synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	mechanistic target of rapamycin kinase	Homo sapiens	164-168
19571375-8	2009	The Akt inhibitor LY294002 synergistically potentiated paeonol-induced inactivation of Akt and vascular endothelial growth factor in bFGF-treated HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	87-90
19571375-8	2009	The Akt inhibitor LY294002 synergistically potentiated paeonol-induced inactivation of Akt and vascular endothelial growth factor in bFGF-treated HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	vascular endothelial growth factor A	Homo sapiens	95-129
19571375-8	2009	The Akt inhibitor LY294002 synergistically potentiated paeonol-induced inactivation of Akt and vascular endothelial growth factor in bFGF-treated HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	fibroblast growth factor 2	Homo sapiens	133-137
19219548-10	2009	Mechanistic studies revealed that the use of LY294002, a PI3 kinase inhibitor, mitigated VEGF-induced expression of platelet-endothelial cell adhesion molecule (PECAM-1/CD31); the trans-endothelial migration of a monocyte cell line (U-937) and angiogenesis in HAEC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	vascular endothelial growth factor A	Homo sapiens	89-93
19246485-8	2009	The blockage of IGF-1 receptor phosphorylation and its downstream PI3K pathway by PPP or LY294002 dramatically reduced their AP activity and expression of pluripotent genes, such as Oct-4, Blimp1, and Nanog.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	insulin-like growth factor 1	Mus musculus	16-21
19246485-8	2009	The blockage of IGF-1 receptor phosphorylation and its downstream PI3K pathway by PPP or LY294002 dramatically reduced their AP activity and expression of pluripotent genes, such as Oct-4, Blimp1, and Nanog.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	182-187
19246485-8	2009	The blockage of IGF-1 receptor phosphorylation and its downstream PI3K pathway by PPP or LY294002 dramatically reduced their AP activity and expression of pluripotent genes, such as Oct-4, Blimp1, and Nanog.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	PR domain containing 1, with ZNF domain	Mus musculus	189-195
19246485-8	2009	The blockage of IGF-1 receptor phosphorylation and its downstream PI3K pathway by PPP or LY294002 dramatically reduced their AP activity and expression of pluripotent genes, such as Oct-4, Blimp1, and Nanog.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	Nanog homeobox	Mus musculus	201-206
19219548-10	2009	Mechanistic studies revealed that the use of LY294002, a PI3 kinase inhibitor, mitigated VEGF-induced expression of platelet-endothelial cell adhesion molecule (PECAM-1/CD31); the trans-endothelial migration of a monocyte cell line (U-937) and angiogenesis in HAEC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	platelet and endothelial cell adhesion molecule 1	Homo sapiens	116-159
19219548-10	2009	Mechanistic studies revealed that the use of LY294002, a PI3 kinase inhibitor, mitigated VEGF-induced expression of platelet-endothelial cell adhesion molecule (PECAM-1/CD31); the trans-endothelial migration of a monocyte cell line (U-937) and angiogenesis in HAEC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	platelet and endothelial cell adhesion molecule 1	Homo sapiens	161-168
19219548-10	2009	Mechanistic studies revealed that the use of LY294002, a PI3 kinase inhibitor, mitigated VEGF-induced expression of platelet-endothelial cell adhesion molecule (PECAM-1/CD31); the trans-endothelial migration of a monocyte cell line (U-937) and angiogenesis in HAEC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	platelet and endothelial cell adhesion molecule 1	Homo sapiens	169-173
19513559-7	2009	Moreover, the activity of Akt was downregulated in WEPN-treated cells and the phosphatidylinositol-3 kinase (PI3K)/Akt inhibitor LY294002 sensitized the cells to WEPN-induced apoptosis through enhancing the activation of caspase-3 and loss of MMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	AKT serine/threonine kinase 1	Homo sapiens	26-29
19513559-7	2009	Moreover, the activity of Akt was downregulated in WEPN-treated cells and the phosphatidylinositol-3 kinase (PI3K)/Akt inhibitor LY294002 sensitized the cells to WEPN-induced apoptosis through enhancing the activation of caspase-3 and loss of MMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	AKT serine/threonine kinase 1	Homo sapiens	115-118
19513559-7	2009	Moreover, the activity of Akt was downregulated in WEPN-treated cells and the phosphatidylinositol-3 kinase (PI3K)/Akt inhibitor LY294002 sensitized the cells to WEPN-induced apoptosis through enhancing the activation of caspase-3 and loss of MMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	caspase 3	Homo sapiens	221-230
19428794-4	2009	LY294002 (but not Go6976) abrogated veratridine-induced Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Bos taurus	56-59
19477492-12	2009	Notably, LTB4-induced migration and proliferation of ASM cells were inhibited by the BLT1 specific antagonist, U75302, and by inhibitors of p42/p44 MAPK phosphorylation (U1026), and PI3 kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	erythrocyte membrane protein band 4.2	Homo sapiens	140-143
21475874-11	2009	This is in sharp contrast to LY294002, which is an inhibitor of phosphatidylinositol 3-kinase, an upstream activator for Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	121-124
19386722-8	2009	Furthermore, the cleavage of both caspase-3 and poly(ADP-ribose) polymerase and terminal deoxynucleotidyl transferase-mediated deoxyuridine nick end labeling assays confirmed that permissive, spontaneously immortalized cells such as A31 cells and mouse embryonic fibroblasts (MEFs) underwent apoptosis upon orthopoxvirus infection plus LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	336-344	deoxynucleotidyltransferase, terminal	Mus musculus	80-117
19428794-5	2009	In contrast, either LY294002 or Go6976 alone attenuated veratridine-induced glycogen synthase kinase-3beta phosphorylation by 65 or 42%; however, LY294002 plus Go6976 completely blocked it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	glycogen synthase kinase 3 beta	Bos taurus	76-106
19301309-11	2009	LY294002 mimicked RES effects on NF kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nuclear factor kappa B subunit 1	Homo sapiens	33-42
19614922-9	2009	HGF-induced in vitro scratch-wound healing was inhibited by PI3K inhibitors, wortmannin and LY294002, while LY303511, an inactive structural analogue of LY294002, had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	hepatocyte growth factor	Homo sapiens	0-3
19614922-9	2009	HGF-induced in vitro scratch-wound healing was inhibited by PI3K inhibitors, wortmannin and LY294002, while LY303511, an inactive structural analogue of LY294002, had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	hepatocyte growth factor	Homo sapiens	0-3
19371940-7	2009	In 786-O cells, the phosphorylation of both extracellular signal-regulated kinase and Akt was inhibited by gefitinib used in combination with either LY294002 or the knockdown of Akt expression, and the viability of 786-O cells was suppressed significantly by gefitinib used in combination with LY294002 (P &lt; .0001) or Akt small interfering RNA (P = .0044).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	AKT serine/threonine kinase 1	Homo sapiens	86-89
19386602-10	2009	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed the IL-1beta-, IFN-gamma- and TNF-alpha-induced IL-32 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	interleukin 1 beta	Homo sapiens	86-94
19371940-7	2009	In 786-O cells, the phosphorylation of both extracellular signal-regulated kinase and Akt was inhibited by gefitinib used in combination with either LY294002 or the knockdown of Akt expression, and the viability of 786-O cells was suppressed significantly by gefitinib used in combination with LY294002 (P &lt; .0001) or Akt small interfering RNA (P = .0044).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	294-302	AKT serine/threonine kinase 1	Homo sapiens	86-89
19386602-10	2009	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed the IL-1beta-, IFN-gamma- and TNF-alpha-induced IL-32 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	interleukin 32	Homo sapiens	130-135
19386602-10	2009	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed the IL-1beta-, IFN-gamma- and TNF-alpha-induced IL-32 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	interferon gamma	Homo sapiens	97-106
19386602-10	2009	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed the IL-1beta-, IFN-gamma- and TNF-alpha-induced IL-32 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	tumor necrosis factor	Homo sapiens	112-121
19429264-4	2009	GSK3beta is known to be a key downstream target of Akt, and LY294002, the PI3K (phosphatidylinositol 3-kinase)/Akt inhibitor, which promoted the dephosphorylation of GSK3beta, significantly attenuated BLM-induced NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	111-114
19409874-4	2009	Treatment of nuclei with a PKC agonist increased ROS while the PKC inhibitor GF109203X or PI3 kinase inhibitor LY294002 abolished Ang II stimulation of ROS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	angiogenin	Homo sapiens	130-133
19429264-4	2009	GSK3beta is known to be a key downstream target of Akt, and LY294002, the PI3K (phosphatidylinositol 3-kinase)/Akt inhibitor, which promoted the dephosphorylation of GSK3beta, significantly attenuated BLM-induced NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	glycogen synthase kinase 3 beta	Homo sapiens	166-174
19217919-8	2009	Similarly, CNP and the inhibitors of ERK1/2 (PD098059) and PI3K (LY294002) attenuated PAI-1 expression induced by TNFalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	11-14
19349275-7	2009	The phosphatidylinositol 3-kinase inhibitor LY294002 dose-dependently inhibited the increase of ADAMTS1 mRNA expression in hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	ADAM metallopeptidase with thrombospondin type 1 motif 1	Homo sapiens	96-103
19217919-8	2009	Similarly, CNP and the inhibitors of ERK1/2 (PD098059) and PI3K (LY294002) attenuated PAI-1 expression induced by TNFalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	serpin family E member 1	Homo sapiens	86-91
19217919-8	2009	Similarly, CNP and the inhibitors of ERK1/2 (PD098059) and PI3K (LY294002) attenuated PAI-1 expression induced by TNFalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	tumor necrosis factor	Homo sapiens	114-122
19297452-12	2009	This TGF-alpha- or EGF-induced increase in sodium current is abolished by a phosphatidylinositol 3-kinase (PI-3 kinase) inhibitor, LY294002, suggesting that PI-3 kinase is involved in the activation of sodium transport.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	transforming growth factor alpha L homeolog	Xenopus laevis	5-14
19297452-12	2009	This TGF-alpha- or EGF-induced increase in sodium current is abolished by a phosphatidylinositol 3-kinase (PI-3 kinase) inhibitor, LY294002, suggesting that PI-3 kinase is involved in the activation of sodium transport.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	107-118
19297452-12	2009	This TGF-alpha- or EGF-induced increase in sodium current is abolished by a phosphatidylinositol 3-kinase (PI-3 kinase) inhibitor, LY294002, suggesting that PI-3 kinase is involved in the activation of sodium transport.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	157-168
19297452-12	2009	This TGF-alpha- or EGF-induced increase in sodium current is abolished by a phosphatidylinositol 3-kinase (PI-3 kinase) inhibitor, LY294002, suggesting that PI-3 kinase is involved in the activation of sodium transport.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	76-105
19416266-8	2009	LY294002 significantly attenuated Asc 2-P-inducible IGF-1 expression and proliferation of follicular keratinocytes in cultured hair follicles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	pyrin domain containing 1	Homo sapiens	34-39
18563306-6	2009	Western blots analysis showed that simvastatin increased the phosphorylation of eNOS and FKHRL1, which can be blocked by the PI3K/AKT pathway blocker LY294002 .	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	forkhead box O3	Rattus norvegicus	89-95
18563306-6	2009	Western blots analysis showed that simvastatin increased the phosphorylation of eNOS and FKHRL1, which can be blocked by the PI3K/AKT pathway blocker LY294002 .	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	AKT serine/threonine kinase 1	Rattus norvegicus	130-133
19416266-8	2009	LY294002 significantly attenuated Asc 2-P-inducible IGF-1 expression and proliferation of follicular keratinocytes in cultured hair follicles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 1	Homo sapiens	52-57
19395875-7	2009	For study of mechanism, the ADAM17 inhibitor TAPI-2 and the PI3K-AKT inhibitor LY294002 were used to counteract high ADAM17 expression or the activated PI3K-AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	65-68
19395875-7	2009	For study of mechanism, the ADAM17 inhibitor TAPI-2 and the PI3K-AKT inhibitor LY294002 were used to counteract high ADAM17 expression or the activated PI3K-AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	ADAM metallopeptidase domain 17	Homo sapiens	117-123
19385062-5	2009	The forskolin-induced Akt/eNOS/NO pathway was completely inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, but not significantly suppressed by PKI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	AKT serine/threonine kinase 1	Homo sapiens	22-25
19369446-7	2009	In contrast, LY-294002 (a PI3K inhibitor) augmented, whereas GSK3beta inhibitors inhibited, IL-1beta-induced RGS4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-22	interleukin-1 beta	Oryctolagus cuniculus	92-100
19395875-7	2009	For study of mechanism, the ADAM17 inhibitor TAPI-2 and the PI3K-AKT inhibitor LY294002 were used to counteract high ADAM17 expression or the activated PI3K-AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	157-160
19385062-5	2009	The forskolin-induced Akt/eNOS/NO pathway was completely inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, but not significantly suppressed by PKI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	nitric oxide synthase 3	Homo sapiens	26-30
19395875-14	2009	ADAM17 activated, whereas ADAM17 siRNA, TAPI-2 and LY294002 deactivated the EGFR-PI3K-AKT signal pathway, which correlated with MDA-MB-231 cell malignant phenotype changes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	86-89
19385062-5	2009	The forskolin-induced Akt/eNOS/NO pathway was completely inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, but not significantly suppressed by PKI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	74-103
19369446-7	2009	In contrast, LY-294002 (a PI3K inhibitor) augmented, whereas GSK3beta inhibitors inhibited, IL-1beta-induced RGS4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-22	regulator of G-protein signaling 4	Oryctolagus cuniculus	109-113
19173293-10	2009	This effect of DeltaNp73alpha resulted in increased thyroid cancer cell proliferation and reduced apoptosis and was reverted by the PI3-kinase inhibitor LY294002, indicating the role of Akt pathway in this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	AKT serine/threonine kinase 1	Homo sapiens	186-189
19277909-5	2009	This protective effect against cytokine-induced beta cell death was, however, not dependent on albumins free sulfhydryl group, but was inhibited by the phosphoinositide 3-kinase (PI3K) inhibitors LY294002 (25 micromol/l) and wortmannin (1 micromol/l), suggesting that albumin may rescue beta cells from cytokine-induced cell death by activation of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	152-177
19398659-10	2009	The presence of the phosphoinositide 3-kinase inhibitor LY294002 blunted Akt phosphorylation and eNOS phosphorylation and the decrease in the response to phenylephrine caused by blockers of ENaC, indicating that the phosphoinositide 3-kinase/Akt pathway was activated after ENaC inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Rattus norvegicus	73-76
19398659-10	2009	The presence of the phosphoinositide 3-kinase inhibitor LY294002 blunted Akt phosphorylation and eNOS phosphorylation and the decrease in the response to phenylephrine caused by blockers of ENaC, indicating that the phosphoinositide 3-kinase/Akt pathway was activated after ENaC inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	190-194
19398659-10	2009	The presence of the phosphoinositide 3-kinase inhibitor LY294002 blunted Akt phosphorylation and eNOS phosphorylation and the decrease in the response to phenylephrine caused by blockers of ENaC, indicating that the phosphoinositide 3-kinase/Akt pathway was activated after ENaC inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Rattus norvegicus	242-245
19398659-10	2009	The presence of the phosphoinositide 3-kinase inhibitor LY294002 blunted Akt phosphorylation and eNOS phosphorylation and the decrease in the response to phenylephrine caused by blockers of ENaC, indicating that the phosphoinositide 3-kinase/Akt pathway was activated after ENaC inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	274-278
19567200-6	2009	The up-regulations of Bcl-xL and IAP by CpG DNA were not inhibited when blocking PI3K by specific inhibitor Ly294002, while the inhibition of p53 by CpG DNA could be blocked by Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	BCL2 like 1	Homo sapiens	22-28
19567200-6	2009	The up-regulations of Bcl-xL and IAP by CpG DNA were not inhibited when blocking PI3K by specific inhibitor Ly294002, while the inhibition of p53 by CpG DNA could be blocked by Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	BCL2 like 1	Homo sapiens	22-28
19567200-6	2009	The up-regulations of Bcl-xL and IAP by CpG DNA were not inhibited when blocking PI3K by specific inhibitor Ly294002, while the inhibition of p53 by CpG DNA could be blocked by Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	alkaline phosphatase, intestinal	Homo sapiens	33-36
19567200-6	2009	The up-regulations of Bcl-xL and IAP by CpG DNA were not inhibited when blocking PI3K by specific inhibitor Ly294002, while the inhibition of p53 by CpG DNA could be blocked by Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	tumor protein p53	Homo sapiens	142-145
19243022-4	2009	TGF-beta-induced MT1-MMP expression was blocked by the specific extracellular regulated kinase-1/2 (ERK1/2) inhibitor PD98059 and the specific phosphoinositide 3-OH kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	transforming growth factor beta 1	Homo sapiens	0-8
19243022-4	2009	TGF-beta-induced MT1-MMP expression was blocked by the specific extracellular regulated kinase-1/2 (ERK1/2) inhibitor PD98059 and the specific phosphoinositide 3-OH kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	matrix metallopeptidase 14	Homo sapiens	17-24
19318457-9	2009	A phosphatidylinositol 3-kinase inhibitor, LY294002, inhibited the IGF-I-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	insulin like growth factor 1	Homo sapiens	67-72
19243022-4	2009	TGF-beta-induced MT1-MMP expression was blocked by the specific extracellular regulated kinase-1/2 (ERK1/2) inhibitor PD98059 and the specific phosphoinositide 3-OH kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	143-171
19472186-7	2009	The effect of reduced insulin was prevented by Go6976 and LY294002, a specific PI 3-kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	insulin	Homo sapiens	22-29
19347904-8	2009	Although LY294002 and similar inhibitors are effective at blocking prostate cancer cell growth, they act upstream of AKT and PTEN and cancer cells can find a way to bypass this inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	117-120
19424594-5	2009	Importantly, both PI3K inhibitor LY294002 and dominant-negative Akt construct promoted tunicamycin- and thapsigargin-induced ERK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	mitogen-activated protein kinase 1	Homo sapiens	125-128
19254925-10	2009	Treatment with phosphatidylinositol 3-kinase (PI3K) inhibitors, LY294002 and wortmannin, reduced leptin expression in 3T3-L1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	leptin	Mus musculus	97-103
19318234-7	2009	ET-1-induced phosphorylation of GSK-3beta(Ser9) was attenuated by inhibitors of phosphatidylinositol 3-kinase (LY294002), Akt (Akt inhibitor VIII), ERK1/2 (PD98059) and by the AMPK agonist 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	glycogen synthase kinase 3 beta	Rattus norvegicus	32-41
19454725-6	2009	Moreover, a PI3K inhibitor (LY294002) suppressed activation of caspases and combined treatment with both SP600125 and LY294002 completely inhibited the activation of caspases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	caspase 6	Homo sapiens	63-71
19454725-6	2009	Moreover, a PI3K inhibitor (LY294002) suppressed activation of caspases and combined treatment with both SP600125 and LY294002 completely inhibited the activation of caspases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	caspase 6	Homo sapiens	166-174
19454725-6	2009	Moreover, a PI3K inhibitor (LY294002) suppressed activation of caspases and combined treatment with both SP600125 and LY294002 completely inhibited the activation of caspases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	caspase 6	Homo sapiens	63-71
19454725-6	2009	Moreover, a PI3K inhibitor (LY294002) suppressed activation of caspases and combined treatment with both SP600125 and LY294002 completely inhibited the activation of caspases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	caspase 6	Homo sapiens	166-174
19347904-8	2009	Although LY294002 and similar inhibitors are effective at blocking prostate cancer cell growth, they act upstream of AKT and PTEN and cancer cells can find a way to bypass this inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	phosphatase and tensin homolog	Homo sapiens	125-129
19307451-5	2009	Cotreatment with the phosphatidylinositol 3 (PI3)-kinase inhibitor, LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], or treatment of cardiomyocytes infected with a dominant negative adenovirus targeted to Akt1 (ADV-dnAkt1) blocked the effects of EPO on nNOS expression, suggesting that EPO regulates nNOS expression via PI3-kinase and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	erythropoietin	Mus musculus	273-276
19258518-10	2009	The PI3K inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride] abolished the H(2)S-mediated activation of AKT and increases tumor necrosis factor alpha and interleukin 1beta levels in caerulein-treated acinar cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	thymoma viral proto-oncogene 1	Mus musculus	137-140
19258518-10	2009	The PI3K inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride] abolished the H(2)S-mediated activation of AKT and increases tumor necrosis factor alpha and interleukin 1beta levels in caerulein-treated acinar cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	tumor necrosis factor	Mus musculus	155-182
19258518-10	2009	The PI3K inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride] abolished the H(2)S-mediated activation of AKT and increases tumor necrosis factor alpha and interleukin 1beta levels in caerulein-treated acinar cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	interleukin 1 beta	Mus musculus	187-204
18996613-5	2009	Phosphatidylinositol 3-kinase inhibitor (PI3K; Ly294002), Akt inhibitor or ERK inhibitor (PD98059) inhibited the OPN-induced increase in the migration of lung cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	secreted phosphoprotein 1	Homo sapiens	113-116
19726366-9	2009	CONCLUSION: EPO at the dose of 1000 mg/kg decreases the incidence of reperfusion arrhythmias in rats, and this effect can be attenuated by LY294002 pretreatment, suggesting that the cardioprotective effect of EPO involves antioxidation mediated by the phosphoinositide 3-kinase (PI3K) pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	erythropoietin	Rattus norvegicus	12-15
19726366-9	2009	CONCLUSION: EPO at the dose of 1000 mg/kg decreases the incidence of reperfusion arrhythmias in rats, and this effect can be attenuated by LY294002 pretreatment, suggesting that the cardioprotective effect of EPO involves antioxidation mediated by the phosphoinositide 3-kinase (PI3K) pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	erythropoietin	Rattus norvegicus	209-212
19274672-7	2009	Treatment of SGC7901/ADR cells with the PI3K inhibitor LY294002 reduced the expression of both p-Akt and P-gp.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	aldo-keto reductase family 1 member B	Homo sapiens	21-24
19274672-7	2009	Treatment of SGC7901/ADR cells with the PI3K inhibitor LY294002 reduced the expression of both p-Akt and P-gp.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	95-100
19274672-7	2009	Treatment of SGC7901/ADR cells with the PI3K inhibitor LY294002 reduced the expression of both p-Akt and P-gp.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	ATP binding cassette subfamily B member 1	Homo sapiens	105-109
18996613-9	2009	The OPN-mediated increases in IKK alpha/beta, IkappaBalpha and p65 Ser(536) phosphorylation were inhibited by Ly294002, Akt inhibitor and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	secreted phosphoprotein 1	Homo sapiens	4-7
18996613-9	2009	The OPN-mediated increases in IKK alpha/beta, IkappaBalpha and p65 Ser(536) phosphorylation were inhibited by Ly294002, Akt inhibitor and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	30-39
18996613-9	2009	The OPN-mediated increases in IKK alpha/beta, IkappaBalpha and p65 Ser(536) phosphorylation were inhibited by Ly294002, Akt inhibitor and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	NFKB inhibitor alpha	Homo sapiens	46-58
18996613-9	2009	The OPN-mediated increases in IKK alpha/beta, IkappaBalpha and p65 Ser(536) phosphorylation were inhibited by Ly294002, Akt inhibitor and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	RELA proto-oncogene, NF-kB subunit	Homo sapiens	63-66
19307451-5	2009	Cotreatment with the phosphatidylinositol 3 (PI3)-kinase inhibitor, LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], or treatment of cardiomyocytes infected with a dominant negative adenovirus targeted to Akt1 (ADV-dnAkt1) blocked the effects of EPO on nNOS expression, suggesting that EPO regulates nNOS expression via PI3-kinase and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	nitric oxide synthase 1, neuronal	Mus musculus	280-284
19307451-5	2009	Cotreatment with the phosphatidylinositol 3 (PI3)-kinase inhibitor, LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], or treatment of cardiomyocytes infected with a dominant negative adenovirus targeted to Akt1 (ADV-dnAkt1) blocked the effects of EPO on nNOS expression, suggesting that EPO regulates nNOS expression via PI3-kinase and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	erythropoietin	Mus musculus	313-316
19307451-5	2009	Cotreatment with the phosphatidylinositol 3 (PI3)-kinase inhibitor, LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], or treatment of cardiomyocytes infected with a dominant negative adenovirus targeted to Akt1 (ADV-dnAkt1) blocked the effects of EPO on nNOS expression, suggesting that EPO regulates nNOS expression via PI3-kinase and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	nitric oxide synthase 1, neuronal	Mus musculus	327-331
19307451-5	2009	Cotreatment with the phosphatidylinositol 3 (PI3)-kinase inhibitor, LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], or treatment of cardiomyocytes infected with a dominant negative adenovirus targeted to Akt1 (ADV-dnAkt1) blocked the effects of EPO on nNOS expression, suggesting that EPO regulates nNOS expression via PI3-kinase and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	thymoma viral proto-oncogene 1	Mus musculus	232-235
19463755-5	2009	Male Wistar rats received bilateral infusions of the GRPR agonist bombesin (BB) or the PI3K inhibitor LY294002 into the CA1 region of the dorsal hippocampus immediately after inhibitory avoidance (IA) conditioning.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	carbonic anhydrase 1	Rattus norvegicus	120-123
19278624-7	2009	LY294002 prevented Bax phosphorylation and resulted in Bax translocation to the mitochondria, cytochrome c release, caspase-3 activation, and cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	19-22
19435898-5	2009	The EGFR inhibitor gefitinib (Iressa) and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 attenuate the rate of DSB repair.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	46-75
19409199-6	2009	Ang1 reversed the above changes concomitantly with significant rising of survival rates of NPCs under OGD, but all these effects of Ang1 could be blocked by either soluble extracellular domain of Tie2 Fc fusion protein (sTie2Fc) or the phosphoinositide 3-kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	330-338	angiopoietin 1	Mus musculus	0-4
19409199-6	2009	Ang1 reversed the above changes concomitantly with significant rising of survival rates of NPCs under OGD, but all these effects of Ang1 could be blocked by either soluble extracellular domain of Tie2 Fc fusion protein (sTie2Fc) or the phosphoinositide 3-kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	330-338	angiopoietin 1	Mus musculus	132-136
19409199-6	2009	Ang1 reversed the above changes concomitantly with significant rising of survival rates of NPCs under OGD, but all these effects of Ang1 could be blocked by either soluble extracellular domain of Tie2 Fc fusion protein (sTie2Fc) or the phosphoinositide 3-kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	330-338	TEK receptor tyrosine kinase	Mus musculus	196-200
19328186-15	2009	Intraventricular injection of LY294002,which is a phosphoinositide 3-kinase (PI3K), vanished the neuroprotective effect in Trx-1 transgenic mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	thioredoxin 1	Mus musculus	123-128
19336408-8	2009	Insulin-induced changes in mtDNA, mitochondrial mass, intracellular ATP content, and transcripts of mitochondrion-associated genes were prevented by blockade of Akt activation with the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	225-233	thymoma viral proto-oncogene 1	Mus musculus	161-164
19401448-9	2009	Pharmacologic inhibition of heregulin-induced phosphoinositide-3-kinase/Akt (with LY294002) and ERK (with U0126) signaling, as well as short interfering RNA-mediated mitogen-activated protein kinase-1 down-regulation, showed ERK signaling as the primary transducer of heregulin signaling to PRL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	72-75
19428994-8	2009	However, alpha-MSH-induced ERK1/2 activation is abolished by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	proopiomelanocortin	Homo sapiens	9-18
19428994-8	2009	However, alpha-MSH-induced ERK1/2 activation is abolished by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	mitogen-activated protein kinase 3	Homo sapiens	27-33
19285956-4	2009	It was found that the specific PI3K inhibitor LY294002 significantly decreased the steady-state expression levels of Cx43 mRNA and protein in osteoblastic cell line, MC3T3-E1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	gap junction protein, alpha 1	Mus musculus	117-121
19278624-7	2009	LY294002 prevented Bax phosphorylation and resulted in Bax translocation to the mitochondria, cytochrome c release, caspase-3 activation, and cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	55-58
19278624-7	2009	LY294002 prevented Bax phosphorylation and resulted in Bax translocation to the mitochondria, cytochrome c release, caspase-3 activation, and cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cytochrome c, somatic	Homo sapiens	94-106
19278624-7	2009	LY294002 prevented Bax phosphorylation and resulted in Bax translocation to the mitochondria, cytochrome c release, caspase-3 activation, and cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Homo sapiens	116-125
19303661-8	2009	Inclusion of the PI-3K kinase inhibitor Ly294002 significantly reduced osteogenic gene expression and ALP activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	alkaline phosphatase, placental	Homo sapiens	102-105
19120326-0	2009	Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	mechanistic target of rapamycin kinase	Homo sapiens	15-19
19120326-0	2009	Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Homo sapiens	40-43
19120326-7	2009	Combined PI3K/mTOR inhibition with LY294002 had pronounced effects on viability but also led to increased AKT phosphorylation after prolonged treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	106-109
19120326-8	2009	In contrast, combination of rapamycin plus LY294002 suppressed AKT phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	63-66
19120326-11	2009	CONCLUSIONS: mTORC1 inhibition with rapamycin and with LY294002 can lead to AKT phosphorylation in melanoma cells via mTORC2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	CREB regulated transcription coactivator 1	Mus musculus	13-19
19120326-11	2009	CONCLUSIONS: mTORC1 inhibition with rapamycin and with LY294002 can lead to AKT phosphorylation in melanoma cells via mTORC2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	76-79
19120326-11	2009	CONCLUSIONS: mTORC1 inhibition with rapamycin and with LY294002 can lead to AKT phosphorylation in melanoma cells via mTORC2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	CREB regulated transcription coactivator 2	Mus musculus	118-124
19120326-12	2009	Combination of rapamycin and LY294002 suppresses AKT phosphorylation but without significant effect on treatment efficacy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	49-52
19309363-4	2009	Beta-catenin expression in Epstein-Barr virus-immortalized B-cell line decreased following treatment with LY294002, an inhibitor of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	catenin beta 1	Homo sapiens	0-12
19383818-6	2009	Although phospho-Akt (pAkt) levels decreased in all cell lines treated with LY294002, sensitivity was variable.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	17-20
19383818-9	2009	Pretreatment pS6 levels correlated with sensitivity to the PI3K inhibitor, LY294002, whereas PI3K and pAkt did not, suggesting that full activation of the PI3K pathway is needed for sensitivity to PI3K inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	taste 2 receptor member 63 pseudogene	Homo sapiens	13-16
19360341-4	2009	Pharmacological inhibition with HER-2 inhibitor AG825, PI3K inhibitor LY294002, MEK1/2 inhibitor PD98095, and p38MAPK inhibitor SB203580 confirmed that PP2A phosphorylation was modulated by the complicated, HER-2/neu-driven downstream signal network, with the PI3K and MEK1/2 positively, while the p38MAPK negatively regulating its tyrosine phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	protein phosphatase 2 phosphatase activator	Homo sapiens	152-156
19235132-4	2009	Pretreatment for 15 min with 10 muM of PI3K/Akt inhibitor LY294002 or with 20 muM PD98059, inhibitor of ERK 1/2, significantly reduced INS-stimulated Akt and ERK 1/2 phosphorylation by 76 and 75%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Rattus norvegicus	44-47
19235132-4	2009	Pretreatment for 15 min with 10 muM of PI3K/Akt inhibitor LY294002 or with 20 muM PD98059, inhibitor of ERK 1/2, significantly reduced INS-stimulated Akt and ERK 1/2 phosphorylation by 76 and 75%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Rattus norvegicus	150-153
19235132-4	2009	Pretreatment for 15 min with 10 muM of PI3K/Akt inhibitor LY294002 or with 20 muM PD98059, inhibitor of ERK 1/2, significantly reduced INS-stimulated Akt and ERK 1/2 phosphorylation by 76 and 75%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	mitogen activated protein kinase 3	Rattus norvegicus	158-165
19130609-6	2009	Induction of survivin involves activation of the phosphatidylinositol-3-kinase/Akt (PI3K/Akt) pathway, which was antagonized by the PI3K-inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	AKT serine/threonine kinase 1	Homo sapiens	79-82
19130609-6	2009	Induction of survivin involves activation of the phosphatidylinositol-3-kinase/Akt (PI3K/Akt) pathway, which was antagonized by the PI3K-inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	84-92
19225041-7	2009	We also demonstrate that a PI3K inhibitor, LY294002, not a MEK inhibitor, PD98059, inhibited IGF1-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	insulin like growth factor 1	Homo sapiens	93-97
19048345-5	2009	RESULTS: The PI-3K inhibitor LY294002 and Akt kinase inhibitor perifosine led to temporal- and dose-dependent increases in complemented FL activities in 293T human kidney cancer cells stably expressing AST (293T/AST) but not in 293T/ASA cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	solute carrier family 17 member 5	Homo sapiens	202-205
19048345-5	2009	RESULTS: The PI-3K inhibitor LY294002 and Akt kinase inhibitor perifosine led to temporal- and dose-dependent increases in complemented FL activities in 293T human kidney cancer cells stably expressing AST (293T/AST) but not in 293T/ASA cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	solute carrier family 17 member 5	Homo sapiens	212-215
19380828-5	2009	For this study, RAW264.7 cells and human peripheral blood monocytes were treated with PI3K inhibitors wortmannin, LY294002, and ZSTK474, resulting in inhibition of LPS-stimulated HMGB1 secretion, whereas inhibitors of NF-kappaB and MAPKs p38 and ERK showed no inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	high mobility group box 1	Homo sapiens	179-184
19380828-5	2009	For this study, RAW264.7 cells and human peripheral blood monocytes were treated with PI3K inhibitors wortmannin, LY294002, and ZSTK474, resulting in inhibition of LPS-stimulated HMGB1 secretion, whereas inhibitors of NF-kappaB and MAPKs p38 and ERK showed no inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	mitogen-activated protein kinase 14	Homo sapiens	238-241
19380828-5	2009	For this study, RAW264.7 cells and human peripheral blood monocytes were treated with PI3K inhibitors wortmannin, LY294002, and ZSTK474, resulting in inhibition of LPS-stimulated HMGB1 secretion, whereas inhibitors of NF-kappaB and MAPKs p38 and ERK showed no inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	mitogen-activated protein kinase 1	Homo sapiens	246-249
19302476-6	2009	The CXCR4 antagonist (T140) or inhibitors for G proteins (Pertussis toxin) and phosphoinositide 3-kinase (PI3K) (LY294002) abolished CXCL12-mediated NPC proliferation and phosphorylation of Akt-1 and FOXO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	C-X-C motif chemokine receptor 4	Homo sapiens	4-9
19302476-6	2009	The CXCR4 antagonist (T140) or inhibitors for G proteins (Pertussis toxin) and phosphoinositide 3-kinase (PI3K) (LY294002) abolished CXCL12-mediated NPC proliferation and phosphorylation of Akt-1 and FOXO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	C-X-C motif chemokine ligand 12	Homo sapiens	133-139
19302476-6	2009	The CXCR4 antagonist (T140) or inhibitors for G proteins (Pertussis toxin) and phosphoinositide 3-kinase (PI3K) (LY294002) abolished CXCL12-mediated NPC proliferation and phosphorylation of Akt-1 and FOXO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Homo sapiens	190-195
19302476-6	2009	The CXCR4 antagonist (T140) or inhibitors for G proteins (Pertussis toxin) and phosphoinositide 3-kinase (PI3K) (LY294002) abolished CXCL12-mediated NPC proliferation and phosphorylation of Akt-1 and FOXO3a.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	forkhead box O3	Homo sapiens	200-206
19268480-5	2009	Treatment of PC12 cells with PI3K inhibitors LY294002 abolished the protective effects of EPO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	erythropoietin	Rattus norvegicus	90-93
19233141-3	2009	Both retain the ability to autophosphorylate Ser608 of p85alpha and are also inhibited by a range of PI 3-kinase inhibitors (Wortmannin, LY294002, PI-103 and PIK-75) to a similar extent as WT p110alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	55-63
19261616-8	2009	Second, LY294002, a PI3K inhibitor, also sensitized resistant HCC cells to TRAIL-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	TNF superfamily member 10	Homo sapiens	75-80
19428936-10	2009	The suppressive effect of quercetin on GRP78 mRNA induction was reproduced by PI3K inhibitors (LY294002 and wortmannin), but not by vitamin C and E. LY294002 failed to suppress the GRP78 mRNA induction in combination with quercetin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	heat shock protein family A (Hsp70) member 5	Homo sapiens	39-44
19426671-7	2009	Treatment of SKOV3 cells with PKI-166 (EGFR1/2 inhibitor), LY294002 (AKT inhibitor), and PD98059 (ERK inhibitor) decreased c-FLIP(L) expression and co-treatment with TRAIL further reduced the level of c-FLIP(L,) respectively, as did TSA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	69-72
19258007-8	2009	The specific PI3K/Akt inhibitor, LY 294002, abolished the phosphorylation of FOXO3a and the anti-apoptotic action of SCF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-42	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
19258007-8	2009	The specific PI3K/Akt inhibitor, LY 294002, abolished the phosphorylation of FOXO3a and the anti-apoptotic action of SCF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-42	forkhead box O3	Rattus norvegicus	77-83
19258007-8	2009	The specific PI3K/Akt inhibitor, LY 294002, abolished the phosphorylation of FOXO3a and the anti-apoptotic action of SCF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-42	KIT ligand	Rattus norvegicus	117-120
19258007-10	2009	SCF up-regulated the expression of MnSOD, which was also inhibited by LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-79	KIT ligand	Rattus norvegicus	0-3
19258007-10	2009	SCF up-regulated the expression of MnSOD, which was also inhibited by LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-79	superoxide dismutase 2	Rattus norvegicus	35-40
19426673-6	2009	When activation of the PI-3-kinase-Akt pathway was prevented by LY-294002 or Akt Inhibitor IV, the cytoprotective effect of PARP inhibition was significantly diminished showing that the activation of PI-3-kinase-Akt cascade had significantly contributed to the cytostatic resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	AKT serine/threonine kinase 1	Homo sapiens	35-38
19292987-3	2009	Treating VSMCs with LY294002, the PI3K/Akt inhibitor, abrogated Am80-induced KLF5 dephosphorylation and reversed Am80-induced suppression of interaction between KLF5 and RAR alpha, whereas treating vascular smooth muscle cells (VSMCs) with SB203580, the p38 kinase inhibitor, attenuated the interaction between KLF5 and RAR alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	39-42
19292987-3	2009	Treating VSMCs with LY294002, the PI3K/Akt inhibitor, abrogated Am80-induced KLF5 dephosphorylation and reversed Am80-induced suppression of interaction between KLF5 and RAR alpha, whereas treating vascular smooth muscle cells (VSMCs) with SB203580, the p38 kinase inhibitor, attenuated the interaction between KLF5 and RAR alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	Kruppel like factor 5	Homo sapiens	77-81
19292987-3	2009	Treating VSMCs with LY294002, the PI3K/Akt inhibitor, abrogated Am80-induced KLF5 dephosphorylation and reversed Am80-induced suppression of interaction between KLF5 and RAR alpha, whereas treating vascular smooth muscle cells (VSMCs) with SB203580, the p38 kinase inhibitor, attenuated the interaction between KLF5 and RAR alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	Kruppel like factor 5	Homo sapiens	161-165
19292987-3	2009	Treating VSMCs with LY294002, the PI3K/Akt inhibitor, abrogated Am80-induced KLF5 dephosphorylation and reversed Am80-induced suppression of interaction between KLF5 and RAR alpha, whereas treating vascular smooth muscle cells (VSMCs) with SB203580, the p38 kinase inhibitor, attenuated the interaction between KLF5 and RAR alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	retinoic acid receptor alpha	Homo sapiens	170-179
19292987-3	2009	Treating VSMCs with LY294002, the PI3K/Akt inhibitor, abrogated Am80-induced KLF5 dephosphorylation and reversed Am80-induced suppression of interaction between KLF5 and RAR alpha, whereas treating vascular smooth muscle cells (VSMCs) with SB203580, the p38 kinase inhibitor, attenuated the interaction between KLF5 and RAR alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mitogen-activated protein kinase 14	Homo sapiens	254-257
19292987-3	2009	Treating VSMCs with LY294002, the PI3K/Akt inhibitor, abrogated Am80-induced KLF5 dephosphorylation and reversed Am80-induced suppression of interaction between KLF5 and RAR alpha, whereas treating vascular smooth muscle cells (VSMCs) with SB203580, the p38 kinase inhibitor, attenuated the interaction between KLF5 and RAR alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	Kruppel like factor 5	Homo sapiens	161-165
19292987-3	2009	Treating VSMCs with LY294002, the PI3K/Akt inhibitor, abrogated Am80-induced KLF5 dephosphorylation and reversed Am80-induced suppression of interaction between KLF5 and RAR alpha, whereas treating vascular smooth muscle cells (VSMCs) with SB203580, the p38 kinase inhibitor, attenuated the interaction between KLF5 and RAR alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	retinoic acid receptor alpha	Homo sapiens	320-329
19426673-6	2009	When activation of the PI-3-kinase-Akt pathway was prevented by LY-294002 or Akt Inhibitor IV, the cytoprotective effect of PARP inhibition was significantly diminished showing that the activation of PI-3-kinase-Akt cascade had significantly contributed to the cytostatic resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	poly(ADP-ribose) polymerase 1	Homo sapiens	124-128
19426671-7	2009	Treatment of SKOV3 cells with PKI-166 (EGFR1/2 inhibitor), LY294002 (AKT inhibitor), and PD98059 (ERK inhibitor) decreased c-FLIP(L) expression and co-treatment with TRAIL further reduced the level of c-FLIP(L,) respectively, as did TSA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	CASP8 and FADD like apoptosis regulator	Homo sapiens	123-129
19229869-6	2009	With LY294002 treatment, both of them lost their ES features even in the presence of LIF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	leukemia inhibitory factor	Mus musculus	85-88
19426671-7	2009	Treatment of SKOV3 cells with PKI-166 (EGFR1/2 inhibitor), LY294002 (AKT inhibitor), and PD98059 (ERK inhibitor) decreased c-FLIP(L) expression and co-treatment with TRAIL further reduced the level of c-FLIP(L,) respectively, as did TSA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	TNF superfamily member 10	Homo sapiens	166-171
19426671-7	2009	Treatment of SKOV3 cells with PKI-166 (EGFR1/2 inhibitor), LY294002 (AKT inhibitor), and PD98059 (ERK inhibitor) decreased c-FLIP(L) expression and co-treatment with TRAIL further reduced the level of c-FLIP(L,) respectively, as did TSA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	CASP8 and FADD like apoptosis regulator	Homo sapiens	201-207
19229869-7	2009	But the differentiation induced by LY294002 on Ex-Nanog J1 cells was slighter lower than that on wild-type J1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	Nanog homeobox	Mus musculus	50-55
19266163-7	2009	Furthermore, mTOR phosphorylation was decreased by LY294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	mechanistic target of rapamycin kinase	Mus musculus	13-17
19229869-9	2009	Exogenous Nanog sustains mouse ES cells pluripotency independent of LIF, and alleviates the differentiation induced by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	Nanog homeobox	Mus musculus	10-15
19357281-6	2009	This result was corroborated by the observation that the selective PI3K inhibitor LY294002 blocked the CB2R stimulation effects on neuronal survival as well as Akt and JNK phosphorylation levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	160-163
19174695-8	2009	Inactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway was also involved, as inhibition of PI3K by LY294002 significantly increased UA-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	20-49
19174695-8	2009	Inactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway was also involved, as inhibition of PI3K by LY294002 significantly increased UA-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	AKT serine/threonine kinase 1	Homo sapiens	57-60
19330341-7	2009	PI3K-specific inhibitor LY294002 reduced EGF- and HGF-stimulated chemokinesis and chemotaxis on collagen I and fibronectin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	epidermal growth factor	Homo sapiens	41-44
19330341-7	2009	PI3K-specific inhibitor LY294002 reduced EGF- and HGF-stimulated chemokinesis and chemotaxis on collagen I and fibronectin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	hepatocyte growth factor	Homo sapiens	50-53
19330341-7	2009	PI3K-specific inhibitor LY294002 reduced EGF- and HGF-stimulated chemokinesis and chemotaxis on collagen I and fibronectin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	fibronectin 1	Homo sapiens	111-122
19136654-9	2009	Incubation of muscles from AMPK kinase dead (KD) and wild-type littermates with the PI3-kinase inhibitor LY-294002 demonstrated that PI3-kinase, but not AMPK, was essential for CNTF-stimulated glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-114	ciliary neurotrophic factor	Mus musculus	177-181
19098317-8	2009	PI3K inhibitor (Ly294002) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro, whereas MEK inhibitor (PD98059) reduced ERK phosphorylation and the expression of VEGF but had no effect on HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	68-78
19098317-8	2009	PI3K inhibitor (Ly294002) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro, whereas MEK inhibitor (PD98059) reduced ERK phosphorylation and the expression of VEGF but had no effect on HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	vascular endothelial growth factor A	Rattus norvegicus	83-87
19098317-8	2009	PI3K inhibitor (Ly294002) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro, whereas MEK inhibitor (PD98059) reduced ERK phosphorylation and the expression of VEGF but had no effect on HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	vascular endothelial growth factor A	Rattus norvegicus	203-207
19098317-8	2009	PI3K inhibitor (Ly294002) significantly decreased pAkt activity and HIF-1alpha and VEGF expression in vivo and in vitro, whereas MEK inhibitor (PD98059) reduced ERK phosphorylation and the expression of VEGF but had no effect on HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	229-239
19353747-3	2009	LY294002, the specific inhibitor of phosphatidylinositol 3-kinase (PI3K), was used to enhance the responses of OSNs to odorants.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	36-65
19130504-9	2009	In addition, LY294002, a specific inhibitor of phosphoinositide 3-kinase (PI3K) inhibited both the Nef-induced p47(phox) phosphorylation and the superoxide anion release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	S100 calcium binding protein B	Homo sapiens	99-102
19130504-9	2009	In addition, LY294002, a specific inhibitor of phosphoinositide 3-kinase (PI3K) inhibited both the Nef-induced p47(phox) phosphorylation and the superoxide anion release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	pleckstrin	Homo sapiens	111-114
19139269-14	2009	Capsaicin and DHC induced Akt phosphorylation, and the phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], induced autophagy via ERK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	mitogen-activated protein kinase 1	Homo sapiens	210-213
18771813-8	2009	Furthermore, the TGF-beta1-mediated increases in IKKalpha/beta, IkappaBalpha phosphorylation and p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	NFKB inhibitor alpha	Homo sapiens	64-76
18771813-5	2009	Besides, we performed that PI3K inhibitor (Ly294002) or Akt inhibitor suppressed the TGF-beta1-induced migration activities of A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	transforming growth factor beta 1	Homo sapiens	85-94
19162061-2	2009	Our in vitro findings, using cerebellar granule neurons, demonstrate that lithium (1-10mM) exerts neuroprotective effects in young cultures (7-8 days) against LY294002-induced Akt inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	thymoma viral proto-oncogene 1	Mus musculus	176-179
18771813-8	2009	Furthermore, the TGF-beta1-mediated increases in IKKalpha/beta, IkappaBalpha phosphorylation and p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	transforming growth factor beta 1	Homo sapiens	17-26
18771813-8	2009	Furthermore, the TGF-beta1-mediated increases in IKKalpha/beta, IkappaBalpha phosphorylation and p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	49-62
18771813-8	2009	Furthermore, the TGF-beta1-mediated increases in IKKalpha/beta, IkappaBalpha phosphorylation and p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	RELA proto-oncogene, NF-kB subunit	Homo sapiens	97-100
19372586-7	2009	Both cisplatin-induced loss of nucleolar SSRP1 and DNA-PK activation are suppressed by pretreatment of the cells with wortmannin or the DNA-PK inhibitor NU7026 but not by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	structure specific recognition protein 1	Homo sapiens	41-46
19372586-7	2009	Both cisplatin-induced loss of nucleolar SSRP1 and DNA-PK activation are suppressed by pretreatment of the cells with wortmannin or the DNA-PK inhibitor NU7026 but not by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	51-57
19372586-7	2009	Both cisplatin-induced loss of nucleolar SSRP1 and DNA-PK activation are suppressed by pretreatment of the cells with wortmannin or the DNA-PK inhibitor NU7026 but not by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	136-142
18787837-4	2009	Although G (Na) is negligible in hormone-deprived cells, these cells displayed basal SGK1 activity that was sensitive to LY294002, an inhibitor of 3-phosphatidylinositol phosphate kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	serum/glucocorticoid regulated kinase 1	Homo sapiens	85-89
19429543-5	2009	The induced eNOS and p-Akt expression was inhibited by LY294002, indicating that the effect of nanocomposites could be attributed to the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	nitric oxide synthase 3	Homo sapiens	12-16
19429543-5	2009	The induced eNOS and p-Akt expression was inhibited by LY294002, indicating that the effect of nanocomposites could be attributed to the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	23-26
19287985-6	2009	The 17beta-estradiol increased HIF-1alpha expression in ovarian cancer cells, and this upregulatory effect was abrogated by Akt inhibitor LY294002 (P&lt;0.05) and Akt siRNA interference (P&lt;0.05), but not affected by MAPK inhibitor PD980059 (P&gt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-41
19287985-6	2009	The 17beta-estradiol increased HIF-1alpha expression in ovarian cancer cells, and this upregulatory effect was abrogated by Akt inhibitor LY294002 (P&lt;0.05) and Akt siRNA interference (P&lt;0.05), but not affected by MAPK inhibitor PD980059 (P&gt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	AKT serine/threonine kinase 1	Homo sapiens	124-127
18787837-8	2009	Forskolin and insulin both stimulated this current and the response to insulin, but not forskolin, was LY294002-sensitive and associated with the activation of SGK1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	serum/glucocorticoid regulated kinase 1	Homo sapiens	160-164
19073151-6	2009	In addition, Western blot analysis of Akt showed that, while the total Akt level remained unchanged, the phosphorylated Akt level was increased by UDCA, and this increase was also prevented by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	AKT serine/threonine kinase 1	Homo sapiens	38-41
19356694-7	2009	In addition, the specific PI3K/Akt inhibitor LY294002 greatly diminished the antiapoptotic effects of SP600125 upon S/K withdrawal, confirming that Akt is involved in the neuroprotection achieved by SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Rattus norvegicus	31-34
19356694-7	2009	In addition, the specific PI3K/Akt inhibitor LY294002 greatly diminished the antiapoptotic effects of SP600125 upon S/K withdrawal, confirming that Akt is involved in the neuroprotection achieved by SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Rattus norvegicus	148-151
19338750-3	2009	The effect of Ang II was markedly attenuated in cells pretreated with wortmannin and LY294002, two selective inhibitors of phosphatidylinositol-3-kinase (PI3K), indicating that PI3K plays a key role in regulating MMP 2 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	angiotensinogen	Homo sapiens	14-20
19338750-3	2009	The effect of Ang II was markedly attenuated in cells pretreated with wortmannin and LY294002, two selective inhibitors of phosphatidylinositol-3-kinase (PI3K), indicating that PI3K plays a key role in regulating MMP 2 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	123-152
19338750-3	2009	The effect of Ang II was markedly attenuated in cells pretreated with wortmannin and LY294002, two selective inhibitors of phosphatidylinositol-3-kinase (PI3K), indicating that PI3K plays a key role in regulating MMP 2 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	matrix metallopeptidase 2	Homo sapiens	213-218
19036873-9	2009	Smad inhibition does not but the phosphatidylinositol 3-kinase (PI3K) signaling pathway inhibitor LY-294002 does inhibit NOX4 and IGFBP-3 gene expression, IGFBP-3 secretion, and cellular proliferation resulting from hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-107	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	33-62
19036873-9	2009	Smad inhibition does not but the phosphatidylinositol 3-kinase (PI3K) signaling pathway inhibitor LY-294002 does inhibit NOX4 and IGFBP-3 gene expression, IGFBP-3 secretion, and cellular proliferation resulting from hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-107	NADPH oxidase 4	Homo sapiens	121-125
19036873-9	2009	Smad inhibition does not but the phosphatidylinositol 3-kinase (PI3K) signaling pathway inhibitor LY-294002 does inhibit NOX4 and IGFBP-3 gene expression, IGFBP-3 secretion, and cellular proliferation resulting from hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-107	insulin like growth factor binding protein 3	Homo sapiens	130-137
19036873-9	2009	Smad inhibition does not but the phosphatidylinositol 3-kinase (PI3K) signaling pathway inhibitor LY-294002 does inhibit NOX4 and IGFBP-3 gene expression, IGFBP-3 secretion, and cellular proliferation resulting from hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-107	insulin like growth factor binding protein 3	Homo sapiens	155-162
19118895-5	2009	The inductions of both eNOS and p-Akt on PU-Au were abolished by the addition of LY294002 (PI3K inhibitor), suggesting that these cellular events may be regulated through the PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	34-37
19331685-8	2009	Finally, the secretion could be attenuated by LY 294002, a specific phosphatidylinositol-3-kinase (PI3K) inhibitor and by SH-5, a selective Akt inhibitor, suggesting that activation of PI3K by AA leads to augmented and sustained MMP-9 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-55	matrix metallopeptidase 9	Homo sapiens	229-234
19428548-7	2009	Treatment with LY294002 (PI3K inhibitor) and SP600125 (JNK inhibitor) suppressed NF-kappaB inhibitor induced MIF mRNA expression and MIF secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mitogen-activated protein kinase 8	Homo sapiens	55-58
19428548-7	2009	Treatment with LY294002 (PI3K inhibitor) and SP600125 (JNK inhibitor) suppressed NF-kappaB inhibitor induced MIF mRNA expression and MIF secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	nuclear factor kappa B subunit 1	Homo sapiens	81-90
19428548-7	2009	Treatment with LY294002 (PI3K inhibitor) and SP600125 (JNK inhibitor) suppressed NF-kappaB inhibitor induced MIF mRNA expression and MIF secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	macrophage migration inhibitory factor	Homo sapiens	109-112
19428548-7	2009	Treatment with LY294002 (PI3K inhibitor) and SP600125 (JNK inhibitor) suppressed NF-kappaB inhibitor induced MIF mRNA expression and MIF secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	macrophage migration inhibitory factor	Homo sapiens	133-136
19428548-8	2009	LY294002 and SP600125 inhibited the parthenolide-induced phosphorylation of c-Jun.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
19073147-5	2009	Also, we found that PI3K inhibitor (Ly294002) or Akt inhibitor suppressed CCL5-induced migration activities and integrin expression of A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	C-C motif chemokine ligand 5	Homo sapiens	74-78
19073147-8	2009	Furthermore, the CCL5-mediated increases in p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	C-C motif chemokine ligand 5	Homo sapiens	17-21
19073147-8	2009	Furthermore, the CCL5-mediated increases in p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	RELA proto-oncogene, NF-kB subunit	Homo sapiens	44-47
19073151-5	2009	We further investigated the effect of UDCA on the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, and obtained results showing that UDCA-induced increase in the GSH level was prevented by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	50-79
19073151-5	2009	We further investigated the effect of UDCA on the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, and obtained results showing that UDCA-induced increase in the GSH level was prevented by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	AKT serine/threonine kinase 1	Homo sapiens	87-90
19073151-6	2009	In addition, Western blot analysis of Akt showed that, while the total Akt level remained unchanged, the phosphorylated Akt level was increased by UDCA, and this increase was also prevented by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	AKT serine/threonine kinase 1	Homo sapiens	71-74
19073151-6	2009	In addition, Western blot analysis of Akt showed that, while the total Akt level remained unchanged, the phosphorylated Akt level was increased by UDCA, and this increase was also prevented by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	AKT serine/threonine kinase 1	Homo sapiens	71-74
19073151-7	2009	Moreover, UDCA promoted the translocation of a transcription factor, nuclear factor-E2-related factor-2 (Nrf2), into the nucleus, and this action was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
19223550-7	2009	These data show that JNK and ERK are two crucial players involved in H(2)O(2)-mediated increase in TRAIL sensitization of tumor cells upon exposure to LY30 and underscore a novel mode of action of this inactive analogue of LY29.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	223-227	mitogen-activated protein kinase 8	Homo sapiens	21-24
19223550-7	2009	These data show that JNK and ERK are two crucial players involved in H(2)O(2)-mediated increase in TRAIL sensitization of tumor cells upon exposure to LY30 and underscore a novel mode of action of this inactive analogue of LY29.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	223-227	mitogen-activated protein kinase 1	Homo sapiens	29-32
19223550-7	2009	These data show that JNK and ERK are two crucial players involved in H(2)O(2)-mediated increase in TRAIL sensitization of tumor cells upon exposure to LY30 and underscore a novel mode of action of this inactive analogue of LY29.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	223-227	TNF superfamily member 10	Homo sapiens	99-104
18654850-7	2009	Inactivation of Akt by treatment with the PI3K chemical inhibitor LY294002 or by overexpression of the dominant negative mutant of Akt (DNMAkt) prevented the protective effect of S1P on apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	16-19
19071214-7	2009	Treatment with LY294002, a PI3 kinase inhibitor, but not with other signal inhibitors, resulted in the loss of delayed STAT3 phosphorylation by HGF/SF, showing the involvement of PI3 kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	signal transducer and activator of transcription 3	Mus musculus	119-124
19071214-7	2009	Treatment with LY294002, a PI3 kinase inhibitor, but not with other signal inhibitors, resulted in the loss of delayed STAT3 phosphorylation by HGF/SF, showing the involvement of PI3 kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	hepatocyte growth factor	Mus musculus	144-150
19385036-6	2009	Similarly, the PI3K inhibitor LY294002 (10 microM; 15 min) and ERK1/2 inhibitor PD98059 (20 microM; 15 min) abolished the INS-mediated increase in cPLA2 phosphorylation by 59% (p &lt; 0.001), and by 75% ( p &lt; 0.001), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	phospholipase A2 group IVA	Rattus norvegicus	147-152
18694845-6	2009	LY 294002 (a PI3K inhibitor) or PD 98059 (an ERK1/2 inhibitor) prevented E(2)-induced increase in caveolin-1 expression and the accompanying [(3)H]-thymidine incorporation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	caveolin 1, caveolae protein	Mus musculus	98-108
19049871-5	2009	Insulin-stimulated ecdysteroidogenesis was blocked by either LY294002 or wortmannin, indicating involvement of the phosphatidylinositol 3-kinase (PI3K) signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	insulin	Bos taurus	0-7
19247195-5	2009	Functional analysis showed that thymosin beta4-induced EPC migration was blocked by phosphatidylinositol 3-kinase inhibitors (LY294002 or wortmannin) or eNOS inhibitor (Nomega-nitro-L-arginine methyl ester) but was not significantly attenuated by mitogen-activated protein kinase (MAPK)/ERK inhibitor (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	thymosin beta 4 X-linked	Homo sapiens	32-46
18708158-2	2009	Toward this goal, we show apoptosis and impaired long-term survival of androgen-independent prostate cancer cells (PC3 and PC3 derivatives) co-treated with the cyclin-dependent kinase (CDK) inhibitor roscovitine and an AKT inhibitor (LY294002 or API-2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	chromobox 8	Homo sapiens	115-118
19158375-5	2009	Chromatin immunoprecipitation assays revealed that p300/CREB-binding protein (CBP) histone acetyltransferases and Nrf2 recruitment to the ARE and Bach1 release were blocked by the PI3K inhibitor LY294002, along with the partial inhibition of Nrf2 nuclear accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	E1A binding protein p300	Homo sapiens	51-55
19255520-6	2009	The inhibition of ERK using PD98059 synergistically enhanced the TET-induced apoptosis of A549 cells whereas the inhibition of Akt using LY294002 had a less significant effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	AKT serine/threonine kinase 1	Homo sapiens	127-130
19103208-6	2009	Inhibitors of STAT1, mitogen activated protein kinase kinase (MEK) (PD98059), and phosphatidyl inositol 3 kinase (PI3K) (LY294002), blocked gp120-induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120-induced monocyte adhesion and migration across in vitro BBB models.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	140-145
19103208-6	2009	Inhibitors of STAT1, mitogen activated protein kinase kinase (MEK) (PD98059), and phosphatidyl inositol 3 kinase (PI3K) (LY294002), blocked gp120-induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120-induced monocyte adhesion and migration across in vitro BBB models.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	signal transducer and activator of transcription 1	Homo sapiens	154-159
19103208-6	2009	Inhibitors of STAT1, mitogen activated protein kinase kinase (MEK) (PD98059), and phosphatidyl inositol 3 kinase (PI3K) (LY294002), blocked gp120-induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120-induced monocyte adhesion and migration across in vitro BBB models.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
19103208-6	2009	Inhibitors of STAT1, mitogen activated protein kinase kinase (MEK) (PD98059), and phosphatidyl inositol 3 kinase (PI3K) (LY294002), blocked gp120-induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120-induced monocyte adhesion and migration across in vitro BBB models.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	interleukin 6	Homo sapiens	207-211
19158375-5	2009	Chromatin immunoprecipitation assays revealed that p300/CREB-binding protein (CBP) histone acetyltransferases and Nrf2 recruitment to the ARE and Bach1 release were blocked by the PI3K inhibitor LY294002, along with the partial inhibition of Nrf2 nuclear accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	CREB binding protein	Homo sapiens	56-76
19158375-5	2009	Chromatin immunoprecipitation assays revealed that p300/CREB-binding protein (CBP) histone acetyltransferases and Nrf2 recruitment to the ARE and Bach1 release were blocked by the PI3K inhibitor LY294002, along with the partial inhibition of Nrf2 nuclear accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	CREB binding protein	Homo sapiens	78-81
19158375-5	2009	Chromatin immunoprecipitation assays revealed that p300/CREB-binding protein (CBP) histone acetyltransferases and Nrf2 recruitment to the ARE and Bach1 release were blocked by the PI3K inhibitor LY294002, along with the partial inhibition of Nrf2 nuclear accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
19158375-5	2009	Chromatin immunoprecipitation assays revealed that p300/CREB-binding protein (CBP) histone acetyltransferases and Nrf2 recruitment to the ARE and Bach1 release were blocked by the PI3K inhibitor LY294002, along with the partial inhibition of Nrf2 nuclear accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	BTB domain and CNC homolog 1	Homo sapiens	146-151
19158375-5	2009	Chromatin immunoprecipitation assays revealed that p300/CREB-binding protein (CBP) histone acetyltransferases and Nrf2 recruitment to the ARE and Bach1 release were blocked by the PI3K inhibitor LY294002, along with the partial inhibition of Nrf2 nuclear accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	NFE2 like bZIP transcription factor 2	Homo sapiens	242-246
19190323-10	2009	Ly294002, an inhibitor of phosphatidylinositol 3-kinase, and dominant-negative AKT, suppressed TCF4 transcriptional activity induced by galectin-3 whereas LiCl, a GSK-3beta inhibitor, increased TCF4 activity, mimicking the effects of galectin-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transcription factor 4	Homo sapiens	95-99
19103208-6	2009	Inhibitors of STAT1, mitogen activated protein kinase kinase (MEK) (PD98059), and phosphatidyl inositol 3 kinase (PI3K) (LY294002), blocked gp120-induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120-induced monocyte adhesion and migration across in vitro BBB models.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	218-223
19041930-7	2009	These effects of VEGF were mediated through the phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) signal transduction pathway, as they were blocked in the presence of the PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	vascular endothelial growth factor A	Rattus norvegicus	17-21
19041930-7	2009	These effects of VEGF were mediated through the phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) signal transduction pathway, as they were blocked in the presence of the PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
19041930-7	2009	These effects of VEGF were mediated through the phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) signal transduction pathway, as they were blocked in the presence of the PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	AKT serine/threonine kinase 1	Rattus norvegicus	89-92
18974235-9	2009	Treatment with the phosphatidylinositol 3-kinase inhibitors wortmannin (100 nmol/L) and LY294002 (10 micromol/L) attenuated insulin-induced Akt phosphorylation, indicating that insulin phosphorylates Akt via a phosphatidylinositol 3-kinase-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Rattus norvegicus	140-143
18974235-9	2009	Treatment with the phosphatidylinositol 3-kinase inhibitors wortmannin (100 nmol/L) and LY294002 (10 micromol/L) attenuated insulin-induced Akt phosphorylation, indicating that insulin phosphorylates Akt via a phosphatidylinositol 3-kinase-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Rattus norvegicus	200-203
19079341-5	2009	Stable overexpression of either PHLPP isoform in colon cancer cells decreased the rate of cell proliferation and sensitized the cells to growth inhibition induced by the phosphoinositide-3 kinase inhibitor, LY294002, whereas knockdown of either PHLPP isoform by shRNA promoted the proliferation of DLD1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	PH domain and leucine rich repeat protein phosphatase 1	Homo sapiens	32-37
19190323-10	2009	Ly294002, an inhibitor of phosphatidylinositol 3-kinase, and dominant-negative AKT, suppressed TCF4 transcriptional activity induced by galectin-3 whereas LiCl, a GSK-3beta inhibitor, increased TCF4 activity, mimicking the effects of galectin-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	galectin 3	Homo sapiens	136-146
19190323-10	2009	Ly294002, an inhibitor of phosphatidylinositol 3-kinase, and dominant-negative AKT, suppressed TCF4 transcriptional activity induced by galectin-3 whereas LiCl, a GSK-3beta inhibitor, increased TCF4 activity, mimicking the effects of galectin-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Homo sapiens	163-172
19190323-10	2009	Ly294002, an inhibitor of phosphatidylinositol 3-kinase, and dominant-negative AKT, suppressed TCF4 transcriptional activity induced by galectin-3 whereas LiCl, a GSK-3beta inhibitor, increased TCF4 activity, mimicking the effects of galectin-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transcription factor 4	Homo sapiens	194-198
19190323-10	2009	Ly294002, an inhibitor of phosphatidylinositol 3-kinase, and dominant-negative AKT, suppressed TCF4 transcriptional activity induced by galectin-3 whereas LiCl, a GSK-3beta inhibitor, increased TCF4 activity, mimicking the effects of galectin-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	galectin 3	Homo sapiens	234-244
19236815-16	2009	When eNOS was blocked by L-NAME or PI3K was blocked by LY294002, the basal level of NO production and the increment of NO caused by VEGF could be significantly decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	vascular endothelial growth factor A	Bos taurus	132-136
19550116-0	2009	Reversal effect of PI3-K inhibitor LY294002 on P-glycoprotein-mediated multidrug resistance of human leukemia cell line K562/DNR and gastric cancer cell line SGC7901/ADR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	ATP binding cassette subfamily B member 1	Homo sapiens	47-61
19550116-2	2009	This study was to explore the reversal effect of PI3-K inhibitor LY294002 on p-glycoprotein (P-gp)-mediated multidrug resistance in human leukemia cell line K562/DNR and gastric cancer cell line SGC7901/ADR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	ATP binding cassette subfamily B member 1	Homo sapiens	77-91
19550116-2	2009	This study was to explore the reversal effect of PI3-K inhibitor LY294002 on p-glycoprotein (P-gp)-mediated multidrug resistance in human leukemia cell line K562/DNR and gastric cancer cell line SGC7901/ADR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
19550116-7	2009	RESULTS: LY294002 pretreatment significantly decreased the 50% inhibition concentration (IC(50)) of DNR, ADR, VCR and VP-16 for K562/DNR cells, with reverse efficiencies of 72.4%, 64.9%, 60.4% and 52.8%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	host cell factor C1	Homo sapiens	118-123
19550116-9	2009	LY294002 pretreatment partially inhibited the expression of p-Akt and P-gp, and promoted the intracellular accumulation of DNR and ADR in K562/DNR and SGC7901/ADR cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	62-65
19550116-9	2009	LY294002 pretreatment partially inhibited the expression of p-Akt and P-gp, and promoted the intracellular accumulation of DNR and ADR in K562/DNR and SGC7901/ADR cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	70-74
19550116-10	2009	CONCLUSION: LY294002 could partially reverse multidrug resistance in K562/DNR and SGC7901/ADR cells in vitro via inhibiting PI3-K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Homo sapiens	130-133
19074484-6	2009	The PI3K inhibitor Ly294002 abolished Akt and p70S6K phosphorylation and reversed the dedifferentiated phenotype via induction of sm-calponin, sm-alpha-actin, SM22alpha, and myosin light chain kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	ribosomal protein S6 kinase B1	Homo sapiens	46-52
19074484-6	2009	The PI3K inhibitor Ly294002 abolished Akt and p70S6K phosphorylation and reversed the dedifferentiated phenotype via induction of sm-calponin, sm-alpha-actin, SM22alpha, and myosin light chain kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	38-41
19074484-6	2009	The PI3K inhibitor Ly294002 abolished Akt and p70S6K phosphorylation and reversed the dedifferentiated phenotype via induction of sm-calponin, sm-alpha-actin, SM22alpha, and myosin light chain kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	transgelin	Homo sapiens	159-168
19074484-6	2009	The PI3K inhibitor Ly294002 abolished Akt and p70S6K phosphorylation and reversed the dedifferentiated phenotype via induction of sm-calponin, sm-alpha-actin, SM22alpha, and myosin light chain kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	myosin light chain kinase	Homo sapiens	174-199
19038372-6	2009	Furthermore, phosphatidylinositol 3-kinase inhibitor (PI3K; Ly294002) or Akt inhibitor suppressed BMP-2-induced MMP-13 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	bone morphogenetic protein 2	Homo sapiens	98-103
19151742-8	2009	RESULTS: Geniposide induced the expression of the antiapoptotic protein Bcl-2, which inhibited apoptosis in PC12 cells induced by H(2)O(2), and this effect could be inhibited by preincubation with LY294002, a selective inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	BCL2, apoptosis regulator	Rattus norvegicus	72-77
19038372-6	2009	Furthermore, phosphatidylinositol 3-kinase inhibitor (PI3K; Ly294002) or Akt inhibitor suppressed BMP-2-induced MMP-13 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	matrix metallopeptidase 13	Homo sapiens	112-118
18983912-5	2009	Lithium and valproate promote but wortmannin and LY294002 attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2, whereas MEK inhibitor PD98059 inhibits nerve growth factor- but not PACAP-induced phosphorylation of GSK3beta, suggesting that GSK3beta operates downstream of Rapt 1 but upstream of ERK1/2 in PACAP signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	adenylate cyclase activating polypeptide 1	Rattus norvegicus	68-73
18983912-5	2009	Lithium and valproate promote but wortmannin and LY294002 attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2, whereas MEK inhibitor PD98059 inhibits nerve growth factor- but not PACAP-induced phosphorylation of GSK3beta, suggesting that GSK3beta operates downstream of Rapt 1 but upstream of ERK1/2 in PACAP signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	glycogen synthase kinase 3 beta	Rattus norvegicus	106-114
18983912-5	2009	Lithium and valproate promote but wortmannin and LY294002 attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2, whereas MEK inhibitor PD98059 inhibits nerve growth factor- but not PACAP-induced phosphorylation of GSK3beta, suggesting that GSK3beta operates downstream of Rapt 1 but upstream of ERK1/2 in PACAP signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mitogen activated protein kinase 3	Rattus norvegicus	119-125
18983912-5	2009	Lithium and valproate promote but wortmannin and LY294002 attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2, whereas MEK inhibitor PD98059 inhibits nerve growth factor- but not PACAP-induced phosphorylation of GSK3beta, suggesting that GSK3beta operates downstream of Rapt 1 but upstream of ERK1/2 in PACAP signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	adenylate cyclase activating polypeptide 1	Rattus norvegicus	195-200
18983912-5	2009	Lithium and valproate promote but wortmannin and LY294002 attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2, whereas MEK inhibitor PD98059 inhibits nerve growth factor- but not PACAP-induced phosphorylation of GSK3beta, suggesting that GSK3beta operates downstream of Rapt 1 but upstream of ERK1/2 in PACAP signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	glycogen synthase kinase 3 beta	Rattus norvegicus	228-236
18983912-5	2009	Lithium and valproate promote but wortmannin and LY294002 attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2, whereas MEK inhibitor PD98059 inhibits nerve growth factor- but not PACAP-induced phosphorylation of GSK3beta, suggesting that GSK3beta operates downstream of Rapt 1 but upstream of ERK1/2 in PACAP signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	glycogen synthase kinase 3 beta	Rattus norvegicus	228-236
18983912-5	2009	Lithium and valproate promote but wortmannin and LY294002 attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2, whereas MEK inhibitor PD98059 inhibits nerve growth factor- but not PACAP-induced phosphorylation of GSK3beta, suggesting that GSK3beta operates downstream of Rapt 1 but upstream of ERK1/2 in PACAP signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mechanistic target of rapamycin kinase	Rattus norvegicus	286-292
19143758-10	2009	However, TGFbeta and LY294002, a potent inhibitor of PI3-kinase, significantly inhibited phosphorylation of both p85 and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	113-116
18983912-5	2009	Lithium and valproate promote but wortmannin and LY294002 attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2, whereas MEK inhibitor PD98059 inhibits nerve growth factor- but not PACAP-induced phosphorylation of GSK3beta, suggesting that GSK3beta operates downstream of Rapt 1 but upstream of ERK1/2 in PACAP signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mitogen activated protein kinase 3	Rattus norvegicus	309-315
19143758-10	2009	However, TGFbeta and LY294002, a potent inhibitor of PI3-kinase, significantly inhibited phosphorylation of both p85 and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	mitogen-activated protein kinase 3	Homo sapiens	121-127
18983912-5	2009	Lithium and valproate promote but wortmannin and LY294002 attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2, whereas MEK inhibitor PD98059 inhibits nerve growth factor- but not PACAP-induced phosphorylation of GSK3beta, suggesting that GSK3beta operates downstream of Rapt 1 but upstream of ERK1/2 in PACAP signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	adenylate cyclase activating polypeptide 1	Rattus norvegicus	195-200
18726116-0	2009	Loss of PTEN function may account for reduced proliferation pathway sensitivity to LY294002 in human prostate and bladder cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	phosphatase and tensin homolog	Homo sapiens	8-12
19143835-7	2009	Inhibition of the PI3K/Akt pathway by one of its specific inhibitors, LY294002, or by Akt small interfering RNA (siRNA) resulted in decreased multidrug resistance of SGC7901 cells, partly through downregulation of P-gp induced by PrP(C).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Homo sapiens	23-26
19143835-7	2009	Inhibition of the PI3K/Akt pathway by one of its specific inhibitors, LY294002, or by Akt small interfering RNA (siRNA) resulted in decreased multidrug resistance of SGC7901 cells, partly through downregulation of P-gp induced by PrP(C).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	ATP binding cassette subfamily B member 1	Homo sapiens	214-218
19143835-7	2009	Inhibition of the PI3K/Akt pathway by one of its specific inhibitors, LY294002, or by Akt small interfering RNA (siRNA) resulted in decreased multidrug resistance of SGC7901 cells, partly through downregulation of P-gp induced by PrP(C).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	prion protein	Homo sapiens	230-236
18726116-6	2009	RESULTS: After 6 weeks, proliferation pathway sensitivity to LY294002 was reduced in cells expressing PTEN, but not in PTEN-null cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	phosphatase and tensin homolog	Homo sapiens	102-106
18844239-5	2009	Interestingly, Egr-1 induction depends on integrin-dependent PI3K/Akt activation, as indicated by the decrease in Egr-1 levels in presence of the pharmacological inhibitor LY294002, the kinase-defective Akt mutant and Akt1/2 shRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	early growth response 1	Homo sapiens	15-20
18844239-5	2009	Interestingly, Egr-1 induction depends on integrin-dependent PI3K/Akt activation, as indicated by the decrease in Egr-1 levels in presence of the pharmacological inhibitor LY294002, the kinase-defective Akt mutant and Akt1/2 shRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	AKT serine/threonine kinase 1	Homo sapiens	66-69
18844239-5	2009	Interestingly, Egr-1 induction depends on integrin-dependent PI3K/Akt activation, as indicated by the decrease in Egr-1 levels in presence of the pharmacological inhibitor LY294002, the kinase-defective Akt mutant and Akt1/2 shRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	early growth response 1	Homo sapiens	114-119
18818290-9	2009	Whereas inhibition of phosphatidylinositol 3 kinase with LY294002 potentiated insulin-induced GLP-1 release, secretion was abrogated by inhibiting the MEK-ERK1/2 pathway with PD98059 or by overexpression of a kinase-dead MEK1-ERK2 fusion protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	glucagon	Mus musculus	94-99
18726116-8	2009	Stable PTEN expression in PTEN-null UM-UC-3 cells increased serum-induced ERK activation and sensitivity to PD98059-treatment, and reduced sensitivity to LY294002 after 6 weeks of exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	phosphatase and tensin homolog	Homo sapiens	7-11
18726116-8	2009	Stable PTEN expression in PTEN-null UM-UC-3 cells increased serum-induced ERK activation and sensitivity to PD98059-treatment, and reduced sensitivity to LY294002 after 6 weeks of exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	phosphatase and tensin homolog	Homo sapiens	26-30
19047197-4	2009	SOCs stimulated by CPA, BAPTA-AM and the phorbol ester phorbol 12,13-dibutyrate (PDBu) were reduced by anti-PIP(2) antibodies and by depletion of tissue PIP(2) levels by pre-treatment of preparations with wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	prolactin-inducible protein homolog	Oryctolagus cuniculus	108-111
19064616-8	2009	Western blots revealed that compared with -LMN myocytes, +LMN myocytes showed a significant increase in Akt phosphorylation at Ser-473, which was prevented by LY.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-161	AKT serine/threonine kinase 1	Homo sapiens	104-107
19047197-4	2009	SOCs stimulated by CPA, BAPTA-AM and the phorbol ester phorbol 12,13-dibutyrate (PDBu) were reduced by anti-PIP(2) antibodies and by depletion of tissue PIP(2) levels by pre-treatment of preparations with wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	prolactin-inducible protein homolog	Oryctolagus cuniculus	153-156
19047197-6	2009	Co-immunoprecipitation techniques demonstrated association between TRPC1 and PIP(2) at rest, which was greatly decreased by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	short transient receptor potential channel 1	Oryctolagus cuniculus	67-72
19047197-6	2009	Co-immunoprecipitation techniques demonstrated association between TRPC1 and PIP(2) at rest, which was greatly decreased by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	prolactin-inducible protein homolog	Oryctolagus cuniculus	77-80
19183465-9	2009	These effects were PI-3k dependent since selective inhibitors of this molecule, wortmannin and LY294002, inhibited both Akt and Bad phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	120-123
18640717-3	2009	PI3K/Akt activity, analyzed by phosphatidylinositol trisphosphate production and phosphorylated Akt (p-Akt) expression, was higher in the resistant cell lines than in the sensitive one and inhibition with wortmannin or LY294002 improved apoptosis in the resistant cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	thymoma viral proto-oncogene 1	Mus musculus	5-8
18640717-5	2009	Wortmannin and LY294002 inhibited P-glycoprotein (Pgp) function and also increased NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	phosphoglycolate phosphatase	Mus musculus	34-48
18640717-5	2009	Wortmannin and LY294002 inhibited P-glycoprotein (Pgp) function and also increased NF-kappaB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	phosphoglycolate phosphatase	Mus musculus	50-53
18978810-8	2009	Moreover, silibinin reduced hypoxia-induced vascular endothelial growth factor (VEGF) release by HeLa and Hep3B cells, and this effect was potentiated by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	vascular endothelial growth factor A	Homo sapiens	44-78
19059380-9	2009	In addition, treatment of a PI3K inhibitor, LY294002, inhibited Akt phosphorylation by calcium-mediated cell-cell adhesion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	64-67
18978810-8	2009	Moreover, silibinin reduced hypoxia-induced vascular endothelial growth factor (VEGF) release by HeLa and Hep3B cells, and this effect was potentiated by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	vascular endothelial growth factor A	Homo sapiens	80-84
18978810-8	2009	Moreover, silibinin reduced hypoxia-induced vascular endothelial growth factor (VEGF) release by HeLa and Hep3B cells, and this effect was potentiated by the PI3K/Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	AKT serine/threonine kinase 1	Homo sapiens	163-166
19033378-7	2009	The effect of ethanol on GSK-3beta activity was reversed by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and ethanol could enhance Akt phosphorylation, implying that the PI3K/Akt pathway accounts for the action of ethanol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	glycogen synthase kinase 3 beta	Rattus norvegicus	25-34
19028450-6	2009	The results show that ectopic expression of Ang1 promotes neuronal differentiation and neurite outgrowth in NPCs, while this effect was blocked by the presence of anti-Tie2 receptor antibody or the PI3-K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	angiopoietin 1	Homo sapiens	44-48
19116273-4	2009	APC also induced phosphorylation of Ser-9 in glycogen synthase kinase 3beta (GSK3beta), which was blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	APC regulator of WNT signaling pathway	Homo sapiens	0-3
19116273-4	2009	APC also induced phosphorylation of Ser-9 in glycogen synthase kinase 3beta (GSK3beta), which was blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	glycogen synthase kinase 3 beta	Homo sapiens	45-75
19116273-4	2009	APC also induced phosphorylation of Ser-9 in glycogen synthase kinase 3beta (GSK3beta), which was blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	glycogen synthase kinase 3 beta	Homo sapiens	77-85
19655410-5	2009	Only LY294002 inhibited Akt activation induced by EGCG, implying that EGCG-induced Akt activation is PI3K dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	AKT serine/threonine kinase 1	Homo sapiens	24-27
19084589-7	2009	Importantly, the manganese-induced COX-2 expression was suppressed by treatment with the inhibitor of p38 MAPK (SB203580), PI3K/PKB (LY294002), PKCs (GO6983, GF109203X, Rottlerin), Src (PP1), or the thiol-containing compound (NAC).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
19027714-3	2009	PI3K inhibitor LY294002, which is known to inhibit NGF-induced PC12 differentiation, blocked up-regulation of Tyro3 and Axl.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	nerve growth factor	Rattus norvegicus	51-54
19027714-3	2009	PI3K inhibitor LY294002, which is known to inhibit NGF-induced PC12 differentiation, blocked up-regulation of Tyro3 and Axl.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	TYRO3 protein tyrosine kinase	Rattus norvegicus	110-115
19027714-3	2009	PI3K inhibitor LY294002, which is known to inhibit NGF-induced PC12 differentiation, blocked up-regulation of Tyro3 and Axl.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	Axl receptor tyrosine kinase	Rattus norvegicus	120-123
19060913-11	2009	Treatment with IGF-1 could accelerate cell cycle progression from G(0)/G(1) to S phase, whereas this progression was inhibited by the presence of LY294002 or BAY11-7082.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	insulin-like growth factor 1	Rattus norvegicus	15-20
19709444-12	2009	When cells were treated with LY294002, a potent phosphoinositide 3-kinase inhibitor, Akt phosphorylation and Bcl-2 levels were reduced and Hsp70 downregulation no longer had a cytoprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	85-88
19709444-12	2009	When cells were treated with LY294002, a potent phosphoinositide 3-kinase inhibitor, Akt phosphorylation and Bcl-2 levels were reduced and Hsp70 downregulation no longer had a cytoprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	BCL2 apoptosis regulator	Homo sapiens	109-114
19709444-12	2009	When cells were treated with LY294002, a potent phosphoinositide 3-kinase inhibitor, Akt phosphorylation and Bcl-2 levels were reduced and Hsp70 downregulation no longer had a cytoprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	heat shock protein family A (Hsp70) member 4	Homo sapiens	139-144
19033378-7	2009	The effect of ethanol on GSK-3beta activity was reversed by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and ethanol could enhance Akt phosphorylation, implying that the PI3K/Akt pathway accounts for the action of ethanol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Rattus norvegicus	146-149
19033378-7	2009	The effect of ethanol on GSK-3beta activity was reversed by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and ethanol could enhance Akt phosphorylation, implying that the PI3K/Akt pathway accounts for the action of ethanol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Rattus norvegicus	190-193
19033378-8	2009	Ethanol prevented oxidant (H(2)O(2))-induced loss DeltaPsi(m), an effect that was reversed by LY294002, indicating that ethanol can modulate the mPTP opening caused by oxidant stress through the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	AKT serine/threonine kinase 1	Rattus norvegicus	200-203
18799305-4	2009	The enhancive effect of LY294002 to the responses of OSNs is also investigated, which is the specific inhibitor of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	115-144
19494504-11	2009	Eotaxin-induced production of IL-1beta, IL-6, and MIP-1beta was significantly reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	C-C motif chemokine ligand 11	Homo sapiens	0-7
19154427-0	2009	Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	potassium voltage-gated channel subfamily A member 5	Homo sapiens	88-93
19255500-7	2009	U73122 (PLC inhibitor), staurosporine (PKC inhibitor), LY294002 (PI3K inhibitor), and Akt inhibitor blocked the phosphorylation of p44/42 MAPKs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	mitogen-activated protein kinase 3	Mus musculus	131-134
19255500-9	2009	LA-induced increases in the cell cycle regulatory proteins, cyclin D1, cyclin E, cyclin-dependent kinase (CDK) 2, and CDK 4, were blocked by U73122, staurosporine, LY294002, Akt inhibitor, PD98059, and metformin (gluconeogenesis inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	cyclin-dependent kinase 4	Mus musculus	118-123
19118035-10	2009	Treatment with the PI3K inhibitors LY294002 or wortmannin resulted in nuclear relocalization of p27, whereas mTOR inhibition by rapamycin did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	dynactin subunit 6	Homo sapiens	96-99
18973754-7	2009	The addition of either the extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor U0126 or Akt inhibitor LY294002 also led to a marked inhibition of the AngII-induced VEGF mRNA and protein production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Homo sapiens	97-100
18973754-7	2009	The addition of either the extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor U0126 or Akt inhibitor LY294002 also led to a marked inhibition of the AngII-induced VEGF mRNA and protein production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	angiotensinogen	Homo sapiens	159-164
18973754-7	2009	The addition of either the extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor U0126 or Akt inhibitor LY294002 also led to a marked inhibition of the AngII-induced VEGF mRNA and protein production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	vascular endothelial growth factor A	Homo sapiens	173-177
19154427-3	2009	Here we examined blockade of hKv1.5 channels by LY294002, a well-known inhibitor of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	potassium voltage-gated channel subfamily A member 5	Homo sapiens	29-35
19154427-6	2009	KEY RESULTS: LY294002 rapidly and reversibly inhibited hKv1.5 current in a concentration-dependent manner (IC(50) of 7.9 micromol.L(-1)).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	potassium voltage-gated channel subfamily A member 5	Homo sapiens	55-61
19154427-8	2009	LY294002 block of hKv1.5 current developed with time during depolarizing voltage-clamp steps, and this blockade was also voltage-dependent with a steep increase over the voltage range for channel openings.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	potassium voltage-gated channel subfamily A member 5	Homo sapiens	18-24
19154427-10	2009	Inhibition by LY294002 was significantly reduced in several hKv1.5 mutant channels: T480A, R487V, I502A, I508A, L510A and V516A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	potassium voltage-gated channel subfamily A member 5	Homo sapiens	60-66
19154427-11	2009	CONCLUSIONS AND IMPLICATIONS: LY294002 acts directly on hKv1.5 currents as an open channel blocker, independently of its effects on PI3K activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	potassium voltage-gated channel subfamily A member 5	Homo sapiens	56-62
19328461-8	2009	Three or 24h after exposure to the inhibitors, all the inhibitors downregulated the level of the phosphorylated ERK1/2, of which the inhibitory roles of PD98059, LY294002 and AG490 were more significant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	mitogen-activated protein kinase 3	Homo sapiens	112-118
19361784-7	2009	LY294002, a specific inhibitor of PI3K, markedly inhibited the DC production of IL-10.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 10	Mus musculus	80-85
19082492-9	2009	Ectopic expression of HA myr-Akt was found to be associated with an increase in pERK, and treatment with LY294002 was shown to block the phosphorylation of Akt and ERK with the restoration of c-JUN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	29-32
19082492-9	2009	Ectopic expression of HA myr-Akt was found to be associated with an increase in pERK, and treatment with LY294002 was shown to block the phosphorylation of Akt and ERK with the restoration of c-JUN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	80-84
19082492-9	2009	Ectopic expression of HA myr-Akt was found to be associated with an increase in pERK, and treatment with LY294002 was shown to block the phosphorylation of Akt and ERK with the restoration of c-JUN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	156-159
19082492-9	2009	Ectopic expression of HA myr-Akt was found to be associated with an increase in pERK, and treatment with LY294002 was shown to block the phosphorylation of Akt and ERK with the restoration of c-JUN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	mitogen-activated protein kinase 1	Homo sapiens	81-84
19082492-9	2009	Ectopic expression of HA myr-Akt was found to be associated with an increase in pERK, and treatment with LY294002 was shown to block the phosphorylation of Akt and ERK with the restoration of c-JUN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	192-197
19363269-5	2009	Furthermore, lovastatin-mediated neuroprotection was shown to be dependent on protein kinase B (PKB)/Akt signaling since treatment with the PKB/Akt inhibitor LY294002 blocked the lovastatin-induced neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	thymoma viral proto-oncogene 1	Mus musculus	78-94
19363269-5	2009	Furthermore, lovastatin-mediated neuroprotection was shown to be dependent on protein kinase B (PKB)/Akt signaling since treatment with the PKB/Akt inhibitor LY294002 blocked the lovastatin-induced neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	thymoma viral proto-oncogene 1	Mus musculus	96-99
19363269-5	2009	Furthermore, lovastatin-mediated neuroprotection was shown to be dependent on protein kinase B (PKB)/Akt signaling since treatment with the PKB/Akt inhibitor LY294002 blocked the lovastatin-induced neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	thymoma viral proto-oncogene 1	Mus musculus	101-104
19363269-5	2009	Furthermore, lovastatin-mediated neuroprotection was shown to be dependent on protein kinase B (PKB)/Akt signaling since treatment with the PKB/Akt inhibitor LY294002 blocked the lovastatin-induced neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	thymoma viral proto-oncogene 1	Mus musculus	140-143
19363269-5	2009	Furthermore, lovastatin-mediated neuroprotection was shown to be dependent on protein kinase B (PKB)/Akt signaling since treatment with the PKB/Akt inhibitor LY294002 blocked the lovastatin-induced neuroprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	thymoma viral proto-oncogene 1	Mus musculus	144-147
19009553-5	2009	Pretreatment of osteoblasts with phosphatidylinositol 3-kinase (PI3K) inhibitor (Ly294002) and Akt inhibitor inhibited the potentiating action of US; these results were further substantiated by transfecting with the dominant negative mutants of p85 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	33-62
19009553-5	2009	Pretreatment of osteoblasts with phosphatidylinositol 3-kinase (PI3K) inhibitor (Ly294002) and Akt inhibitor inhibited the potentiating action of US; these results were further substantiated by transfecting with the dominant negative mutants of p85 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	245-248
19009553-5	2009	Pretreatment of osteoblasts with phosphatidylinositol 3-kinase (PI3K) inhibitor (Ly294002) and Akt inhibitor inhibited the potentiating action of US; these results were further substantiated by transfecting with the dominant negative mutants of p85 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	253-256
19009553-8	2009	US-increased the binding of c-Fos and c-Jun to the AP-1 element on the BMP-2 promoter and the enhancement of AP-1 luciferase activity was inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
19009553-8	2009	US-increased the binding of c-Fos and c-Jun to the AP-1 element on the BMP-2 promoter and the enhancement of AP-1 luciferase activity was inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
19009553-8	2009	US-increased the binding of c-Fos and c-Jun to the AP-1 element on the BMP-2 promoter and the enhancement of AP-1 luciferase activity was inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	51-55
19009553-8	2009	US-increased the binding of c-Fos and c-Jun to the AP-1 element on the BMP-2 promoter and the enhancement of AP-1 luciferase activity was inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	bone morphogenetic protein 2	Homo sapiens	71-76
19009553-8	2009	US-increased the binding of c-Fos and c-Jun to the AP-1 element on the BMP-2 promoter and the enhancement of AP-1 luciferase activity was inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-113
19494504-11	2009	Eotaxin-induced production of IL-1beta, IL-6, and MIP-1beta was significantly reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	interleukin 1 beta	Homo sapiens	30-38
19494504-11	2009	Eotaxin-induced production of IL-1beta, IL-6, and MIP-1beta was significantly reduced by the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, or PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	C-C motif chemokine ligand 4	Homo sapiens	50-59
18975057-7	2009	Physiological significance of these kinase activations was established by demonstrating that inhibition of Akt by LY294002 and ERK1/2 by PD98059 compromised the cardioprotective effect of all the substances studied.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
18840672-7	2009	Blocking the pathway of phosphatidylinositol 3-kinase (PI3K)/Akt with the specific inhibitor LY294002 decreased the proliferation and elevated RHOB protein level, indicating that PI3K/Akt signal plays its role of proliferation modulation upstream of RHOB protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	24-53
18840672-7	2009	Blocking the pathway of phosphatidylinositol 3-kinase (PI3K)/Akt with the specific inhibitor LY294002 decreased the proliferation and elevated RHOB protein level, indicating that PI3K/Akt signal plays its role of proliferation modulation upstream of RHOB protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	thymoma viral proto-oncogene 1	Mus musculus	61-64
18840672-7	2009	Blocking the pathway of phosphatidylinositol 3-kinase (PI3K)/Akt with the specific inhibitor LY294002 decreased the proliferation and elevated RHOB protein level, indicating that PI3K/Akt signal plays its role of proliferation modulation upstream of RHOB protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	ras homolog family member B	Mus musculus	143-147
18840672-7	2009	Blocking the pathway of phosphatidylinositol 3-kinase (PI3K)/Akt with the specific inhibitor LY294002 decreased the proliferation and elevated RHOB protein level, indicating that PI3K/Akt signal plays its role of proliferation modulation upstream of RHOB protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	thymoma viral proto-oncogene 1	Mus musculus	184-187
18840672-7	2009	Blocking the pathway of phosphatidylinositol 3-kinase (PI3K)/Akt with the specific inhibitor LY294002 decreased the proliferation and elevated RHOB protein level, indicating that PI3K/Akt signal plays its role of proliferation modulation upstream of RHOB protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	ras homolog family member B	Mus musculus	250-254
19827268-5	2009	Inhibitors of PI3K (LY294002) and Akt (SH-6) enhanced resveratrol-induced LDH release and caspase-3 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	caspase 3	Homo sapiens	90-99
19155632-7	2009	It also caused phosphorylation of Akt and eNOS, which were prevented by MnTMPyP, polyethyleneglycol catalase, PP2, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	AKT serine/threonine kinase 1	Homo sapiens	34-37
19155632-7	2009	It also caused phosphorylation of Akt and eNOS, which were prevented by MnTMPyP, polyethyleneglycol catalase, PP2, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	nitric oxide synthase 3	Homo sapiens	42-46
19325702-9	2009	Although the PH/G domain deletion by itself did not result in embryonic defect, addition of PI3K inhibitor LY294002 did give a defective phenotype in the PH/G deletion morphants, indicating that the PH/G domain was essential for Mtmr8"s function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	myotubularin related protein 8	Danio rerio	229-234
19147533-10	2009	Treatment of cells with phosphoinositidyl 3-kinase inhibitor (LY294002) and constitutively activator (insulin-like growth factor I) had significant effects on the anoikis of SKP2 RNA interference cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	S-phase kinase associated protein 2	Homo sapiens	174-178
18923065-5	2009	However, the YC-1-mediated induction of HO-1 was inhibited by the phosphatidylinositol-3-kinase (PI3K) inhibitors wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	RNA binding motif single stranded interacting protein 1	Homo sapiens	13-17
18923065-5	2009	However, the YC-1-mediated induction of HO-1 was inhibited by the phosphatidylinositol-3-kinase (PI3K) inhibitors wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	heme oxygenase 1	Homo sapiens	40-44
19408575-0	2009	Suppression of prometastatic phenotype of highly metastatic androgen-independent rat prostate cancer MLL cell line by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	lysine methyltransferase 2A	Rattus norvegicus	101-104
19408575-3	2009	Moreover, LY294002 attenuated expression of urokinase plasminogen activator (uPA) without any significant effect on that of matrix metalloproteinase 2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	plasminogen activator, urokinase	Rattus norvegicus	44-75
19408575-3	2009	Moreover, LY294002 attenuated expression of urokinase plasminogen activator (uPA) without any significant effect on that of matrix metalloproteinase 2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	plasminogen activator, urokinase	Rattus norvegicus	77-80
19139118-4	2009	We found that cells that overexpress Bcl-xL are resistant to LY294002-induced apoptosis, whereas cells that express little Bcl-xL readily are not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	BCL2 like 1	Homo sapiens	37-43
19139118-5	2009	Restoring Bcl-xL expression in cells that express low level of Bcl-xL conferred resistance to apoptosis in response to LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	BCL2 like 1	Homo sapiens	10-16
19139118-5	2009	Restoring Bcl-xL expression in cells that express low level of Bcl-xL conferred resistance to apoptosis in response to LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	BCL2 like 1	Homo sapiens	63-69
19139118-6	2009	The simultaneous inhibition of the PI3K/Akt pathway by LY294002 or Akt1 small interfering RNA and Bcl-xL function by ABT-737 or Bcl-xL small interfering RNA greatly enhanced the apoptotic response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	40-43
19325702-10	2009	Moreover, we investigated the cooperation of Mtmr8 with PI3K in actin filament modeling and muscle development, and found that both Mtmr8-MO1 and Mtmr8-MO2+LY294002 led to the disorganization of the actin cytoskeleton.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	myotubularin related protein 8	Danio rerio	45-50
19347742-10	2009	EPO enhanced Akt activation and eNOS protein expression, whereas LY294002 or L-NAME partially abolished the anti-hypertrophic effect of EPO, accompanied by a decrease in Akt activation, eNOS protein expression and/or a reduction of NO production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	erythropoietin	Rattus norvegicus	136-139
19190753-8	2009	In contrast, inhibitors for PI3-kinase (LY294002 and wortmannin) or the MAPK cascade (PD98059 and U0126) significantly attenuated this CP-AMPAR-dependent LTP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	28-31
19347742-10	2009	EPO enhanced Akt activation and eNOS protein expression, whereas LY294002 or L-NAME partially abolished the anti-hypertrophic effect of EPO, accompanied by a decrease in Akt activation, eNOS protein expression and/or a reduction of NO production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Rattus norvegicus	170-173
20641681-8	2004	For example, PAI-2 (triciribine) and perifosine are potent and selective inhibitors of Akt, rapamycin is an inhibitor for downstream mTOR, and LY294002 is an inhibitor for upstream PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	serpin family B member 2	Homo sapiens	13-18
18992713-5	2008	We also found that PGE(2) increased the phosphorylation of Akt, which was significantly inhibited by the PI3 kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	AKT serine/threonine kinase 1	Rattus norvegicus	59-62
19077250-10	2008	Experiments using PD98059 and LY294002, inhibitors of the Erk and phosphatidylinositol 3-kinase (PI3K) pathways, respectively, showed that PI3K is not necessary for TPA-induced migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	mitogen-activated protein kinase 1	Homo sapiens	58-61
19018257-6	2008	TAM67 increased dephosphorylation of Akt induced by LY294002 and reduced the TPA response element DNA-binding of phosphorylated c-Jun.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	37-40
18854312-10	2008	The pathway by which RhoA mediates cardiomyocyte Akt activation is demonstrated to require Rho kinase, FAK and PI3K, but not Src, based on studies with pharmacological inhibitors (Y-27632, LY294002, PF271 and PP2) and inhibitory protein expression (FAK-related nonkinase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	ras homolog family member A	Homo sapiens	21-25
18854312-10	2008	The pathway by which RhoA mediates cardiomyocyte Akt activation is demonstrated to require Rho kinase, FAK and PI3K, but not Src, based on studies with pharmacological inhibitors (Y-27632, LY294002, PF271 and PP2) and inhibitory protein expression (FAK-related nonkinase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	AKT serine/threonine kinase 1	Homo sapiens	49-52
18854173-4	2008	The PAR2-triggered IL-8 release was suppressed by inhibitors of MEK (U0126) or PI3-kinase (LY294002), and PAR2 stimulation indeed activated the downstream kinases, ERK and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	F2R like trypsin receptor 1	Homo sapiens	4-8
18854173-4	2008	The PAR2-triggered IL-8 release was suppressed by inhibitors of MEK (U0126) or PI3-kinase (LY294002), and PAR2 stimulation indeed activated the downstream kinases, ERK and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
18854173-5	2008	U0126 blocked the phosphorylation of ERK, but not Akt, and LY294002 blocked the phosphorylation of Akt, but not ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	99-102
18831964-1	2008	LY294002 (LY29) is a commonly used pharmacologic inhibitor of the phosphatidylinositol 3-kinase (PI3K) and has shown antitumorigenic effect both in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	66-95
18831964-1	2008	LY294002 (LY29) is a commonly used pharmacologic inhibitor of the phosphatidylinositol 3-kinase (PI3K) and has shown antitumorigenic effect both in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-4	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	66-95
18831964-2	2008	Both LY29 and its inactive analogue, LY303511 (LY30), significantly up-regulated early growth response gene 1 (Egr-1) expression in HL-60 leukemic cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-9	early growth response 1	Homo sapiens	111-116
18831964-6	2008	Our results indicated for the first time that LY29 could suppress leukemia cell invasion and migration at least in part through up-regulation of Egr-1, independent of its PI3K-Akt inhibitory activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-50	early growth response 1	Homo sapiens	145-150
18948121-6	2008	Furthermore, the BK-induced increase in COX-2 expression was blocked by the PI-3 kinase inhibitors wortmannin and LY294002, Akt inhibitor, and the protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I, suggesting the role of PI-3 kinase and PKC in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	kininogen 1	Homo sapiens	17-19
18948121-6	2008	Furthermore, the BK-induced increase in COX-2 expression was blocked by the PI-3 kinase inhibitors wortmannin and LY294002, Akt inhibitor, and the protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I, suggesting the role of PI-3 kinase and PKC in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19356108-8	2008	The adiponectin mediated increase in peNOS and pAKT was prevented by the phosphatidylinositol-3 kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	4-15
18815209-11	2008	Presence of PI3K inhibitor (LY294002) or MC3/4R antagonist (SHU9119) significantly attenuated the renal SNA response to leptin in DIO and agouti obese mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	leptin	Mus musculus	120-126
19029977-8	2008	LY294002 (phosphatidylinositol 3-kinase inhibitor) and/or PD98059 (MEK inhibitor) diminished the enhanced contractile response to endothelin-1 in aortae from insulin-treated diabetic rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	endothelin 1	Rattus norvegicus	130-142
19026161-7	2008	The inhibition of the PI3K/Akt pathway using the LY294002 inhibitor prevented hypoxia-inhibited apoptosis in EPC and altered the phosphorylation state of glycogen synthase kinase-3beta, an effector protein involved in regulation of EPC apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Homo sapiens	27-30
19026161-7	2008	The inhibition of the PI3K/Akt pathway using the LY294002 inhibitor prevented hypoxia-inhibited apoptosis in EPC and altered the phosphorylation state of glycogen synthase kinase-3beta, an effector protein involved in regulation of EPC apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	glycogen synthase kinase 3 beta	Homo sapiens	154-184
18931031-5	2008	HCMVEC exposed to 500 microM H2O2 had increased Akt phosphorylation within 10 min at both Ser-473 and Thr-308 sites, an effect blocked by the phosphatidylinositol 3-kinase inhibitor LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-191	AKT serine/threonine kinase 1	Homo sapiens	48-51
18931031-6	2008	H2O2 also induced NO generation that was associated with NOS3 Ser-1177 site phosphorylation and Thr-495 dephosphorylation, with Ser-1177 effects attenuated by LY-294002 and an Akt inhibitor, Akt/PKB signaling inhibitor-2 (API-2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-168	baculoviral IAP repeat containing 3	Homo sapiens	191-220
18931031-6	2008	H2O2 also induced NO generation that was associated with NOS3 Ser-1177 site phosphorylation and Thr-495 dephosphorylation, with Ser-1177 effects attenuated by LY-294002 and an Akt inhibitor, Akt/PKB signaling inhibitor-2 (API-2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-168	baculoviral IAP repeat containing 3	Homo sapiens	222-227
18814278-6	2008	LY294002, an inhibitor of PI3 kinase, abolished PIP(3) waves in stalled cells and stopped keratocyte-like cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	prolactin induced protein	Homo sapiens	48-51
18615584-5	2008	Inhibition of PI3-K with either LY294002 or dominant negative PI3-K reduced DbcAMP-stimulated SGK1 protein and mRNA levels, attenuated the phosphorylation of CREB (a cAMP-activated transcription factor) and decreased alpha-ENaC protein levels and Na(+) transport.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	WAP four-disulfide core domain 15B	Rattus norvegicus	14-17
18849546-4	2008	Furthermore, PI3-K inhibitor LY294002 attenuated OPN-mediated Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	secreted phosphoprotein 1	Homo sapiens	49-52
18849546-4	2008	Furthermore, PI3-K inhibitor LY294002 attenuated OPN-mediated Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	62-65
18266951-6	2008	NGF-mediated protection was dependent on phosphatidylinositol-3 kinase (PI3K) signalling since all above apoptotic events, including expression and phosphorylation status of BimEL protein, could be reverted by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	nerve growth factor	Rattus norvegicus	0-3
18266963-11	2008	Pre-treatment of C-pc-stimulated cells with pharmacological inhibitor of PI-3K (LY294002) annulled the expression of GTPases implying that Rac 1 and Cdc 42 were induced through PI-3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	Rac family small GTPase 1	Mus musculus	139-144
18615584-5	2008	Inhibition of PI3-K with either LY294002 or dominant negative PI3-K reduced DbcAMP-stimulated SGK1 protein and mRNA levels, attenuated the phosphorylation of CREB (a cAMP-activated transcription factor) and decreased alpha-ENaC protein levels and Na(+) transport.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	94-98
18266963-11	2008	Pre-treatment of C-pc-stimulated cells with pharmacological inhibitor of PI-3K (LY294002) annulled the expression of GTPases implying that Rac 1 and Cdc 42 were induced through PI-3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	cell division cycle 42	Mus musculus	149-155
18672053-5	2008	Under the stimulation of such 5-HT application the phosphorylation of Akt and p42/p44 mitogen-activated protein (MAP) kinase is activated and specifically blocked by inhibitors of phosphatidylinositol 3-kinase (PI3-K) (LY294002) or the p42/p44 MAP kinase (PD98059 and U0126) pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	AKT serine/threonine kinase 1	Rattus norvegicus	70-73
18672053-5	2008	Under the stimulation of such 5-HT application the phosphorylation of Akt and p42/p44 mitogen-activated protein (MAP) kinase is activated and specifically blocked by inhibitors of phosphatidylinositol 3-kinase (PI3-K) (LY294002) or the p42/p44 MAP kinase (PD98059 and U0126) pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	180-209
18817526-7	2008	Furthermore, the inhibitors LY294002 and wortmannin, which inhibit direct recycling of Tf from SEs to the plasma membrane, also block its appearance in G-clathrin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	transferrin	Homo sapiens	87-89
18672053-6	2008	Moreover, LY294002, or PD98059, or U0126 partially inhibit 5-HT-stimulated increases in GAD67 or GAD65 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	glutamate decarboxylase 1	Rattus norvegicus	88-93
18672053-6	2008	Moreover, LY294002, or PD98059, or U0126 partially inhibit 5-HT-stimulated increases in GAD67 or GAD65 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	glutamate decarboxylase 2	Rattus norvegicus	97-102
18672053-7	2008	Further, 5-HT application has no effect on the number of GAD65/GAD67-immunopositive neuronal cells; but it can induce an increase in the total area, process length and number of primary neurites of GAD65/67-positive neurons, an increase that appears to involve LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	261-269	glutamate decarboxylase 2	Rattus norvegicus	198-203
18520705-5	2008	However, pretreatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 increased apoptosis more effectively in IL-18- than in LPS-stimulated cells, whereas the ERK inhibitor PD98059 had the same effect in both.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	31-60
18520705-5	2008	However, pretreatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 increased apoptosis more effectively in IL-18- than in LPS-stimulated cells, whereas the ERK inhibitor PD98059 had the same effect in both.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	interleukin 18	Homo sapiens	127-132
18520705-5	2008	However, pretreatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 increased apoptosis more effectively in IL-18- than in LPS-stimulated cells, whereas the ERK inhibitor PD98059 had the same effect in both.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	mitogen-activated protein kinase 1	Homo sapiens	176-179
18720410-4	2008	Pretreated of JJ012 cells with phosphatidylinositol 3-kinase inhibitor (PI3K; Ly294002) or Akt inhibitor inhibited the BMP-2-mediated migration and integrin expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	31-70
18720410-4	2008	Pretreated of JJ012 cells with phosphatidylinositol 3-kinase inhibitor (PI3K; Ly294002) or Akt inhibitor inhibited the BMP-2-mediated migration and integrin expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	bone morphogenetic protein 2	Homo sapiens	119-124
18720410-8	2008	Furthermore, the BMP-2-mediated increasing of IKKalpha/beta phosphorylation, IkappaB phosphorylation, and p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	bone morphogenetic protein 2	Homo sapiens	17-22
18720410-8	2008	Furthermore, the BMP-2-mediated increasing of IKKalpha/beta phosphorylation, IkappaB phosphorylation, and p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	46-54
18720410-8	2008	Furthermore, the BMP-2-mediated increasing of IKKalpha/beta phosphorylation, IkappaB phosphorylation, and p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	RELA proto-oncogene, NF-kB subunit	Homo sapiens	106-109
19017959-6	2008	The FcepsilonRI-dependent activation of Btk and eicosanoid and ROS generation in bone marrow-derived mast cells and human mast cells were similarly blocked by the PI3K inhibitors, Wortmannin and LY294002, indicating that Btk-regulated eicosanoid and ROS production occurs downstream of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	Fc epsilon receptor Ia	Homo sapiens	4-15
19017959-6	2008	The FcepsilonRI-dependent activation of Btk and eicosanoid and ROS generation in bone marrow-derived mast cells and human mast cells were similarly blocked by the PI3K inhibitors, Wortmannin and LY294002, indicating that Btk-regulated eicosanoid and ROS production occurs downstream of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	Bruton tyrosine kinase	Homo sapiens	40-43
19017959-6	2008	The FcepsilonRI-dependent activation of Btk and eicosanoid and ROS generation in bone marrow-derived mast cells and human mast cells were similarly blocked by the PI3K inhibitors, Wortmannin and LY294002, indicating that Btk-regulated eicosanoid and ROS production occurs downstream of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	Bruton tyrosine kinase	Homo sapiens	221-224
19131705-6	2008	AECM-induced apoptosis was associated with the inhibition of Akt activation in a time-dependent manner, and pretreatment with LY294002, a PI3K/Akt inhibitor, significantly increased AECM-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	AKT serine/threonine kinase 1	Homo sapiens	61-64
19131705-6	2008	AECM-induced apoptosis was associated with the inhibition of Akt activation in a time-dependent manner, and pretreatment with LY294002, a PI3K/Akt inhibitor, significantly increased AECM-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	AKT serine/threonine kinase 1	Homo sapiens	143-146
18695355-8	2008	Cytochrome c release during osteoclast apoptosis was inhibited by AG490 treatment, but this effect was inhibited in the presence of LY294002 or U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	cytochrome c, somatic	Homo sapiens	0-12
19133826-4	2008	We find that LY294002 enhances the migration defect of kit(ts), implicating the phosphatidylinositol-3-kinase kinase pathway in promoting kit-dependent melanocyte migration, but not survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	KIT proto-oncogene, receptor tyrosine kinase a	Danio rerio	55-58
18789886-3	2008	Furthermore, inhibition of Src tyrosine kinases, or phosphoinositide 3-kinase with PP1 or LY294002, respectively, blocked beta2 integrin-induced degranulation and the redistribution of Rap1 and Rap2 to a membrane-enriched fraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	122-127
18789886-3	2008	Furthermore, inhibition of Src tyrosine kinases, or phosphoinositide 3-kinase with PP1 or LY294002, respectively, blocked beta2 integrin-induced degranulation and the redistribution of Rap1 and Rap2 to a membrane-enriched fraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	RAP1A, member of RAS oncogene family	Homo sapiens	185-189
19032736-2	2008	We examined the potential of the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002 to enhance the anti-tumor effect of cisplatin and investigated the mechanism of chemoresistance in pancreatic cancer cells using a combination therapy of cisplatin and LY294002, both in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	33-62
19032736-2	2008	We examined the potential of the phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002 to enhance the anti-tumor effect of cisplatin and investigated the mechanism of chemoresistance in pancreatic cancer cells using a combination therapy of cisplatin and LY294002, both in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Homo sapiens	70-73
19032736-9	2008	In the in vivo study, blocking the PI3K/Akt cascade with LY294002 increased the efficacy of cisplatin-induced inhibition of tumor growth in nude mice, suppressing half the tumor growth with cisplatin alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	thymoma viral proto-oncogene 1	Mus musculus	40-43
18804099-7	2008	Activation of Akt in A172 cells could be reversed by pre-treatment of the cells with the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002, indicating involvement of PI3K activity in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	AKT serine/threonine kinase 1	Homo sapiens	14-17
18718903-8	2008	Conversely, transduction with dominant-negative Akt or LY294002 blocked Fstl1-stimulated eNOS phosphorylation and inhibited Fstl1-stimulated cellular responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	follistatin-like 1	Mus musculus	72-77
18718903-8	2008	Conversely, transduction with dominant-negative Akt or LY294002 blocked Fstl1-stimulated eNOS phosphorylation and inhibited Fstl1-stimulated cellular responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	follistatin-like 1	Mus musculus	124-129
18948104-6	2008	In cultured skeletal muscle cells, FGF21 expression and secretion was regulated by insulin, Akt transduction and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	fibroblast growth factor 21	Mus musculus	35-40
18805481-4	2008	The increased NF-kappaB activity with subsequent MMP-2 production by HNE was significantly attenuated by transfection with Akt siRNA as well as by pretreatment with the PI3K/Akt inhibitors LY294002 (10 microM) and SH-5 (1.0 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	matrix metallopeptidase 2	Homo sapiens	49-54
18805481-4	2008	The increased NF-kappaB activity with subsequent MMP-2 production by HNE was significantly attenuated by transfection with Akt siRNA as well as by pretreatment with the PI3K/Akt inhibitors LY294002 (10 microM) and SH-5 (1.0 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	AKT serine/threonine kinase 1	Homo sapiens	174-177
18814920-6	2008	PI3K inhibition by inhibitors wortmannin or LY294002 abrogated protection of stress-induced immune suppression in TLR4-deficient mice compared with TLR4-deficient mice that did not receive the inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	toll-like receptor 4	Mus musculus	114-118
18786922-7	2008	Blockade of Akt activation by LY294002, FoxO1 translocation by constitutively nuclear FoxO1 mutant, or c-Src activation by the chemical inhibitor PP2, respectively, blunted SDF-1 suppression of gluconeogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	12-15
18819004-4	2008	While IL6-mediated JAK/STAT3 and PI3K/AKT signaling was important for proliferation of both cell lines, as shown in proliferation assays using the respective pathway inhibitors, AG490 and LY294002, the resistant cells were insensitive to induction of apoptosis using the same.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	interleukin 6	Mus musculus	6-9
19080172-7	2008	However, the changes of LDH activity, apoptosis rate, and caspase-3 activity were inhibited by LY294002 and UO126 respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	caspase 3	Rattus norvegicus	58-67
18791828-5	2008	Fas-mediated apoptosis and activation of caspase 3/8 were induced in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	caspase 3	Homo sapiens	41-50
19011674-5	2008	The phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (10 micromol/L) prevented any capsaicin-induced survival effect in hippocampal neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	4-29
18718566-9	2008	The phosphatidyl inositol 3 kinase (PI3K) inhibitor LY294002 inhibited IGF-I-induced cell migration and wound healing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	insulin-like growth factor 1	Mus musculus	71-76
18949384-11	2008	The PI3-kinase inhibitor LY294002 significantly inhibited VEGF production in HMGB1-stimulated macrophages, while other kinase inhibitors did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	vascular endothelial growth factor A	Homo sapiens	58-62
19330070-4	2008	The crucial role of lipid second messengers in PKB activation has been dissected through the use of the PI3K-specific inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	AKT serine/threonine kinase 1	Homo sapiens	47-50
18949356-7	2008	The PI3K inhibitor (LY294002) and the AKT inhibitor (AKT inhibitor IV) also partially decreased uPA expression, whereas SP600125, a JNK inhibitor, did not affect uPA levels in either radiated or non-radiated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	plasminogen activator, urokinase	Homo sapiens	96-99
18949358-11	2008	PIK3 kinase inhibitor LY294002 antagonized the effect of estrogen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	0-4
18949384-11	2008	The PI3-kinase inhibitor LY294002 significantly inhibited VEGF production in HMGB1-stimulated macrophages, while other kinase inhibitors did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	high mobility group box 1	Homo sapiens	77-82
19193202-7	2008	Pretreatment with the PI3K inhibitor LY294002 suppressed the increase in TNF-alpha mRNA expression and the phosphorylation of Akt in response to CA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	tumor necrosis factor	Rattus norvegicus	73-82
18767116-5	2008	The increased XIAP protein stability was lessened by PI3K inhibitor LY294002 treatment in cFLIPs overexpressing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	X-linked inhibitor of apoptosis	Homo sapiens	14-18
18767116-5	2008	The increased XIAP protein stability was lessened by PI3K inhibitor LY294002 treatment in cFLIPs overexpressing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	CASP8 and FADD like apoptosis regulator	Homo sapiens	90-96
18762555-6	2008	Expression of the transcription factor, Pax8, which stimulates NIS expression, was significantly increased in PCCL3 cells after LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	paired box 8	Rattus norvegicus	40-44
18762555-10	2008	Pharmacological inhibition of Akt, a factor stimulated by the PI3K pathway, increased exogenous NIS expression in BHP 2-7 as was seen with LY294002, but not increase the endogenous NIS expression in FRTL-5 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Rattus norvegicus	30-33
18773906-11	2008	Inhibition of the PI3-kinase/Akt/mTOR/p70S6kinase signaling pathway negated the biological functions of cultured EPCs, either migration (by LY294002 for PI3-kinase and Rapamycin for mTOR) or survival and tubulogenesis (by Rapamycin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	mechanistic target of rapamycin kinase	Homo sapiens	33-37
18790053-4	2008	Treatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), abolished ER-mediated up-regulation of a CYP7B1 promoter-luciferase reporter in HepG2 cells, whereas overexpression of PI3K or Akt significantly increased estrogenic up-regulation of CYP7B1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	49-78
18790053-4	2008	Treatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), abolished ER-mediated up-regulation of a CYP7B1 promoter-luciferase reporter in HepG2 cells, whereas overexpression of PI3K or Akt significantly increased estrogenic up-regulation of CYP7B1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	estrogen receptor 1	Homo sapiens	97-99
18790053-4	2008	Treatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), abolished ER-mediated up-regulation of a CYP7B1 promoter-luciferase reporter in HepG2 cells, whereas overexpression of PI3K or Akt significantly increased estrogenic up-regulation of CYP7B1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	128-134
18790053-4	2008	Treatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), abolished ER-mediated up-regulation of a CYP7B1 promoter-luciferase reporter in HepG2 cells, whereas overexpression of PI3K or Akt significantly increased estrogenic up-regulation of CYP7B1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	214-217
18790053-4	2008	Treatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), abolished ER-mediated up-regulation of a CYP7B1 promoter-luciferase reporter in HepG2 cells, whereas overexpression of PI3K or Akt significantly increased estrogenic up-regulation of CYP7B1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	270-276
18641171-13	2008	Administration of IGF-I, a PI3K/Akt activator, in ASB15+ was able to partially override the previously observed phenotype of delayed differentiation, whereas administration of the PI3K/ Akt inhibitor, LY294002, decreased phosphorylation of Akt and differentiation of all cell lines similar to the untreated ASB15+ myoblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	thymoma viral proto-oncogene 1	Mus musculus	186-189
18641171-13	2008	Administration of IGF-I, a PI3K/Akt activator, in ASB15+ was able to partially override the previously observed phenotype of delayed differentiation, whereas administration of the PI3K/ Akt inhibitor, LY294002, decreased phosphorylation of Akt and differentiation of all cell lines similar to the untreated ASB15+ myoblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	thymoma viral proto-oncogene 1	Mus musculus	186-189
18773906-11	2008	Inhibition of the PI3-kinase/Akt/mTOR/p70S6kinase signaling pathway negated the biological functions of cultured EPCs, either migration (by LY294002 for PI3-kinase and Rapamycin for mTOR) or survival and tubulogenesis (by Rapamycin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	AKT serine/threonine kinase 1	Homo sapiens	29-32
19034873-9	2008	LY294002, NH4Cl, CAPE, PD098059 and SB202190 all reduced albumin-mediated IL-6 release, but neither PDTC nor MG132 had any effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	albumin	Homo sapiens	57-64
19034873-9	2008	LY294002, NH4Cl, CAPE, PD098059 and SB202190 all reduced albumin-mediated IL-6 release, but neither PDTC nor MG132 had any effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 6	Homo sapiens	74-78
19193202-7	2008	Pretreatment with the PI3K inhibitor LY294002 suppressed the increase in TNF-alpha mRNA expression and the phosphorylation of Akt in response to CA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Rattus norvegicus	126-129
18667481-6	2008	Akt activation was blocked by an inhibitor of PI3K, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Rattus norvegicus	0-3
18812223-10	2008	However, inhibition of Akt activity through PI3 kinase inhibitor LY294002 did not result in obstruction of p38MAPK phosphorylation by H(2)O(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	23-26
19173824-8	2008	LY294002 may significantly elevate the sensitivity of PC9/G cells to cisplatin (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	proprotein convertase subtilisin/kexin type 9	Homo sapiens	54-57
18671941-4	2008	However, inhibition of K(ATP) currents by IGF-I was abolished by the tyrosine kinase inhibitor genistein or the phosphoinositide 3-kinase inhibitors, LY 294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-159	insulin-like growth factor 1	Rattus norvegicus	42-47
18832563-4	2008	Infusion of PI3K inhibitors (wortmannin and LY294002) and an mTOR inhibitor (rapamycin) into the mPFC in vivo suppressed HFS-induced LTP as well as the phosphorylation of PI3K/Akt-mTOR signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	176-179
18832563-4	2008	Infusion of PI3K inhibitors (wortmannin and LY294002) and an mTOR inhibitor (rapamycin) into the mPFC in vivo suppressed HFS-induced LTP as well as the phosphorylation of PI3K/Akt-mTOR signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	mechanistic target of rapamycin kinase	Homo sapiens	180-184
18632801-8	2008	TNF-alpha also caused PI3-kinase/Akt activation, which was further increased by PDTC and prevented by the PI3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	tumor necrosis factor	Homo sapiens	0-9
18632801-8	2008	TNF-alpha also caused PI3-kinase/Akt activation, which was further increased by PDTC and prevented by the PI3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	AKT serine/threonine kinase 1	Homo sapiens	33-36
18632801-10	2008	LY294002 treatment resulted in the appearance of increased apoptosis, compatible with the known anti-apoptotic properties of PI3-kinase/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	136-139
18675921-6	2008	LY294002 (selective inhibitor of PI3K) blocked Akt phosphorylation and abolished IGF2-driven elevation of the mRNA levels of the proteoglycans, Aggrecan and Versican.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	47-50
18628489-8	2008	Inhibition of AKT by LY294002 (a PI3K inhibitor) blocked BCL10 nuclear translocation, NF-kappaB transactivity, and BAFF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	14-17
18628489-8	2008	Inhibition of AKT by LY294002 (a PI3K inhibitor) blocked BCL10 nuclear translocation, NF-kappaB transactivity, and BAFF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	BCL10 immune signaling adaptor	Homo sapiens	57-62
18628489-8	2008	Inhibition of AKT by LY294002 (a PI3K inhibitor) blocked BCL10 nuclear translocation, NF-kappaB transactivity, and BAFF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	nuclear factor kappa B subunit 1	Homo sapiens	86-95
18798061-5	2008	LY294002 could reduce COX-2 induce cells viability, migration and proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
18829558-6	2008	Treatment of cells with the PI3K inhibitor LY294002 before release from stress resulted in a concentration-dependent loss of EGFR activation, whereas treatment with the MAPK inhibitor PD98059 did not block EGFR activation, indicating that EGFR activation was downstream of the IGF1R/PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	epidermal growth factor receptor	Homo sapiens	125-129
18829558-6	2008	Treatment of cells with the PI3K inhibitor LY294002 before release from stress resulted in a concentration-dependent loss of EGFR activation, whereas treatment with the MAPK inhibitor PD98059 did not block EGFR activation, indicating that EGFR activation was downstream of the IGF1R/PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	insulin like growth factor 1 receptor	Homo sapiens	277-282
18675921-6	2008	LY294002 (selective inhibitor of PI3K) blocked Akt phosphorylation and abolished IGF2-driven elevation of the mRNA levels of the proteoglycans, Aggrecan and Versican.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 2	Homo sapiens	81-85
18675921-6	2008	LY294002 (selective inhibitor of PI3K) blocked Akt phosphorylation and abolished IGF2-driven elevation of the mRNA levels of the proteoglycans, Aggrecan and Versican.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	versican	Homo sapiens	157-165
18700866-4	2008	RESULTS: Inhibition of NF-kappaB transcriptional activity by transient transfection with mutant plasmids encoding Akt1 and glycogen synthase kinase-3beta (GSK-3beta), or by treatment with chemical inhibitors, wortmannin and LY294002, showed little effect on the survival of Chang/HBx cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	nuclear factor kappa B subunit 1	Homo sapiens	23-32
18599181-14	2008	When resistant cells were treated with LY 294002 (a PI3K inhibitor), the expression level of phosphorylated Akt was distinctly downregulated, and there was induction of apoptosis when these cells were treated with a combination of TRAIL and LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	AKT serine/threonine kinase 1	Homo sapiens	108-111
18973551-9	2008	Inhibition of the D2/D3 receptor signalling pathway to ERK was obtained with PD98059, GF109203 or LY294002, resulting in blockade of neurotrophic effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	mitogen-activated protein kinase 1	Mus musculus	55-58
18679704-5	2008	Furthermore, the neurite outgrowth-promoting activity of CNTF was diminished by co-treatment with Janus kinase (JAK) 2 inhibitor, AG490; STAT3 inhibitor, STA-21; phosphatidyl inositol-3"-phosphate-kinase (PI3K) inhibitor, LY294002; and mitogen-activated protein kinase kinase (MEK) inhibitor, PD98059, in a concentration-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	222-230	ciliary neurotrophic factor	Rattus norvegicus	57-61
18462913-8	2008	Further study revealed that LY294002, an inhibitor of PI3-kinase (a molecule upstream of Akt), enhanced 6-OHDA-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	89-92
18599181-14	2008	When resistant cells were treated with LY 294002 (a PI3K inhibitor), the expression level of phosphorylated Akt was distinctly downregulated, and there was induction of apoptosis when these cells were treated with a combination of TRAIL and LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	TNF superfamily member 10	Homo sapiens	231-236
18599181-14	2008	When resistant cells were treated with LY 294002 (a PI3K inhibitor), the expression level of phosphorylated Akt was distinctly downregulated, and there was induction of apoptosis when these cells were treated with a combination of TRAIL and LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	241-250	AKT serine/threonine kinase 1	Homo sapiens	108-111
18599181-14	2008	When resistant cells were treated with LY 294002 (a PI3K inhibitor), the expression level of phosphorylated Akt was distinctly downregulated, and there was induction of apoptosis when these cells were treated with a combination of TRAIL and LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	241-250	TNF superfamily member 10	Homo sapiens	231-236
18981661-7	2008	Similar to I3C, modulation of Akt activation through the phosphoinositide-3 kinase inhibitor, LY294002, could also prevent H(2)O(2)-induced inhibition of GJIC and phosphorylation of Cx43.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	AKT serine/threonine kinase 1	Rattus norvegicus	30-33
18565131-9	2008	The phosphatidylinositol 3"-kinase (PI3K) inhibitor, LY294002, and the mammalian target of rapamycin (mTOR) inhibitor, rapamycin, exerted an inhibitory effect on the thrombin-induced OPG synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	coagulation factor II, thrombin	Homo sapiens	166-174
18565131-9	2008	The phosphatidylinositol 3"-kinase (PI3K) inhibitor, LY294002, and the mammalian target of rapamycin (mTOR) inhibitor, rapamycin, exerted an inhibitory effect on the thrombin-induced OPG synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	TNF receptor superfamily member 11b	Homo sapiens	183-186
18565131-11	2008	Activation of phospho-Akt (p-Akt) was observed and the effect was abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	22-25
18565131-11	2008	Activation of phospho-Akt (p-Akt) was observed and the effect was abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	29-32
18981661-7	2008	Similar to I3C, modulation of Akt activation through the phosphoinositide-3 kinase inhibitor, LY294002, could also prevent H(2)O(2)-induced inhibition of GJIC and phosphorylation of Cx43.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	gap junction protein, alpha 1	Rattus norvegicus	182-186
18652836-5	2008	We also show that the PI3K pathway, but not the MAPK pathway, mediates the increases in levels of Ser(1412) phosphorylation and NO production induced by ERbeta activation, as the selective PI3K inhibitor, LY294002 (10microM), blocked the effects of ERbeta activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	estrogen receptor 2	Homo sapiens	153-159
18852117-9	2008	Targeted inhibition of the phosphatidylinositol 3-kinase/AKT pathway with LY294002, in combination with docetaxel, resulted in a synergistic effect in previously docetaxel-resistant cell lines but not with cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	57-60
18581203-6	2008	AVP-induced increase in DNA synthesis could be attenuated by the specific inhibitors of ERK1/2 (PD98059), PI3K (LY294002), and AKT (1L-6-hydroxymethyl-chiro-inositol 2-(R)-2-O-methyl-3-O-octadecylcarbonate, HIMO).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	arginine vasopressin	Rattus norvegicus	0-3
18657281-0	2008	LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
18657281-0	2008	LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	91-120
18657281-2	2008	While investigating whether phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone (CT)-induced COX-2, we found that LY294002 (LY29) but not wortmannin (WM) attenuates CT from inducing COX-2 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	28-57
18657281-2	2008	While investigating whether phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone (CT)-induced COX-2, we found that LY294002 (LY29) but not wortmannin (WM) attenuates CT from inducing COX-2 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
18657281-2	2008	While investigating whether phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone (CT)-induced COX-2, we found that LY294002 (LY29) but not wortmannin (WM) attenuates CT from inducing COX-2 gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-134	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	28-57
18483465-6	2008	Furthermore, pretreatment of cells with the PI3-kinase (PI3K)/Akt inhibitor, LY294002, markedly enhanced TNF alpha-induced down-regulation of the ER alpha protein, suggesting that the PI3K/Akt pathway might be involved in control of the ER alpha level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	44-54
18483465-6	2008	Furthermore, pretreatment of cells with the PI3-kinase (PI3K)/Akt inhibitor, LY294002, markedly enhanced TNF alpha-induced down-regulation of the ER alpha protein, suggesting that the PI3K/Akt pathway might be involved in control of the ER alpha level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	62-65
18483465-6	2008	Furthermore, pretreatment of cells with the PI3-kinase (PI3K)/Akt inhibitor, LY294002, markedly enhanced TNF alpha-induced down-regulation of the ER alpha protein, suggesting that the PI3K/Akt pathway might be involved in control of the ER alpha level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	tumor necrosis factor	Homo sapiens	105-114
18483465-6	2008	Furthermore, pretreatment of cells with the PI3-kinase (PI3K)/Akt inhibitor, LY294002, markedly enhanced TNF alpha-induced down-regulation of the ER alpha protein, suggesting that the PI3K/Akt pathway might be involved in control of the ER alpha level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	estrogen receptor 1	Homo sapiens	146-154
18483465-6	2008	Furthermore, pretreatment of cells with the PI3-kinase (PI3K)/Akt inhibitor, LY294002, markedly enhanced TNF alpha-induced down-regulation of the ER alpha protein, suggesting that the PI3K/Akt pathway might be involved in control of the ER alpha level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	189-192
18483465-6	2008	Furthermore, pretreatment of cells with the PI3-kinase (PI3K)/Akt inhibitor, LY294002, markedly enhanced TNF alpha-induced down-regulation of the ER alpha protein, suggesting that the PI3K/Akt pathway might be involved in control of the ER alpha level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	estrogen receptor 1	Homo sapiens	237-245
18483465-8	2008	In contrast, the effect of the PI3K/Akt inhibitor on ER alpha was blocked in cells that were treated with LY294002 in the presence of the proteasome inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	AKT serine/threonine kinase 1	Homo sapiens	36-39
18483465-8	2008	In contrast, the effect of the PI3K/Akt inhibitor on ER alpha was blocked in cells that were treated with LY294002 in the presence of the proteasome inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	estrogen receptor 1	Homo sapiens	53-61
18515365-5	2008	IL-1 induces phosphorylation of IKKalpha on the NFkappaB inducing kinase (NIK) phosphorylation sites Ser(176)/Ser(180) and on the Thr(23) site, and although phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, phosphorylation of Ser(176)/Ser(180) is not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	209-217	interleukin 1 beta	Homo sapiens	0-4
18515365-5	2008	IL-1 induces phosphorylation of IKKalpha on the NFkappaB inducing kinase (NIK) phosphorylation sites Ser(176)/Ser(180) and on the Thr(23) site, and although phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, phosphorylation of Ser(176)/Ser(180) is not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	209-217	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	32-40
18611860-5	2008	Both cell survival and survivin expression were stunted in CCL2-stimulated PC3 cells when treated either with the phosphatidylinositol 3-kinase inhibitor LY294002 (2 microm) or the Akt-specific inhibitor-X (Akti-X; 2.5 microm).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	C-C motif chemokine ligand 2	Homo sapiens	59-63
18468786-4	2008	Treatment of C19 with LY294002, which inhibits PI-3 kinase and inhibits AKT, significantly increased apoptosis induction by TNF plus cycloheximide and eliminated phosphorylation of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Homo sapiens	72-75
18468786-4	2008	Treatment of C19 with LY294002, which inhibits PI-3 kinase and inhibits AKT, significantly increased apoptosis induction by TNF plus cycloheximide and eliminated phosphorylation of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	tumor necrosis factor	Homo sapiens	124-127
18468786-4	2008	Treatment of C19 with LY294002, which inhibits PI-3 kinase and inhibits AKT, significantly increased apoptosis induction by TNF plus cycloheximide and eliminated phosphorylation of AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	AKT serine/threonine kinase 1	Homo sapiens	181-184
18611860-6	2008	Furthermore, CCL2 significantly reduced light chain 3-II (LC3-II) in serum-starved PC3; in contrast, treatment with LY294002 or Akti-X reversed the effect of CCL2 on LC3-II levels, suggesting that CCL2 signaling limits autophagy in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	C-C motif chemokine ligand 2	Homo sapiens	158-162
18611860-5	2008	Both cell survival and survivin expression were stunted in CCL2-stimulated PC3 cells when treated either with the phosphatidylinositol 3-kinase inhibitor LY294002 (2 microm) or the Akt-specific inhibitor-X (Akti-X; 2.5 microm).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	keratin 6A	Homo sapiens	75-78
18611860-6	2008	Furthermore, CCL2 significantly reduced light chain 3-II (LC3-II) in serum-starved PC3; in contrast, treatment with LY294002 or Akti-X reversed the effect of CCL2 on LC3-II levels, suggesting that CCL2 signaling limits autophagy in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	166-169
18611860-6	2008	Furthermore, CCL2 significantly reduced light chain 3-II (LC3-II) in serum-starved PC3; in contrast, treatment with LY294002 or Akti-X reversed the effect of CCL2 on LC3-II levels, suggesting that CCL2 signaling limits autophagy in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	C-C motif chemokine ligand 2	Homo sapiens	158-162
18785877-8	2008	Administration of LY294002, an inhibitor of PI3K/Akt, decreased the level of pCREB after SCI, whereas PD98059, an inhibitor of ERK, showed no significant effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	49-52
18653476-2	2008	Notably, both are inhibited by wortmannin and LY294002 and signal through phosphatidylinositol-3-kinase (PI3K)-dependent kinases SGK1 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	serum/glucocorticoid regulated kinase 1	Homo sapiens	129-133
18653476-2	2008	Notably, both are inhibited by wortmannin and LY294002 and signal through phosphatidylinositol-3-kinase (PI3K)-dependent kinases SGK1 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	138-141
18660440-3	2008	The effect of zinc on GSK-3beta activity was blocked by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002 but not by the mammalian target of rapamycin (mTOR) inhibitor rapamycin or the PKC inhibitor chelerythrine, implying that PI3K but not mTOR or PKC accounts for the action of zinc.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-116	glycogen synthase kinase 3 beta	Homo sapiens	22-31
18660440-3	2008	The effect of zinc on GSK-3beta activity was blocked by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002 but not by the mammalian target of rapamycin (mTOR) inhibitor rapamycin or the PKC inhibitor chelerythrine, implying that PI3K but not mTOR or PKC accounts for the action of zinc.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-116	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	60-89
18695939-6	2008	Wortmannin and LY294002, specific phosphatidylinositol kinase (PI3K) inhibitors, reversed the effect of HAb18G/CD147 on the regulation of intracellular Ca(2+) mobilization, significantly reducing cell adhesion, invasion and MMPs secretion potential (p&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	basigin (Ok blood group)	Homo sapiens	111-116
18729215-6	2008	With EGF-induced activation of EGFR, we demonstrated phosphorylation in PI3K/Akt, MEK/ERK, and p38 MAPK pathways; with pathway inhibitors (LY294002, U0126, SB203580) the EGF-mediated decrease in papillae was reversed, and synergistic actions were shown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	epidermal growth factor	Homo sapiens	5-8
18729215-6	2008	With EGF-induced activation of EGFR, we demonstrated phosphorylation in PI3K/Akt, MEK/ERK, and p38 MAPK pathways; with pathway inhibitors (LY294002, U0126, SB203580) the EGF-mediated decrease in papillae was reversed, and synergistic actions were shown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	epidermal growth factor receptor	Homo sapiens	31-35
18729215-6	2008	With EGF-induced activation of EGFR, we demonstrated phosphorylation in PI3K/Akt, MEK/ERK, and p38 MAPK pathways; with pathway inhibitors (LY294002, U0126, SB203580) the EGF-mediated decrease in papillae was reversed, and synergistic actions were shown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Homo sapiens	77-80
18729215-6	2008	With EGF-induced activation of EGFR, we demonstrated phosphorylation in PI3K/Akt, MEK/ERK, and p38 MAPK pathways; with pathway inhibitors (LY294002, U0126, SB203580) the EGF-mediated decrease in papillae was reversed, and synergistic actions were shown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	mitogen-activated protein kinase 1	Homo sapiens	99-103
18729215-6	2008	With EGF-induced activation of EGFR, we demonstrated phosphorylation in PI3K/Akt, MEK/ERK, and p38 MAPK pathways; with pathway inhibitors (LY294002, U0126, SB203580) the EGF-mediated decrease in papillae was reversed, and synergistic actions were shown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	epidermal growth factor	Homo sapiens	31-34
19051078-4	2008	However, myotubes became increasingly susceptible to menadione when phosphoinositide 3-kinase (PI3-K) was blocked by pre-incubation with LY294002, a PI3-K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	68-93
19051078-7	2008	Both LY294002 and API-2, an Akt inhibitor, decreased the Bcl-2/Bax ratio in menadione-exposed myotubes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	AKT serine/threonine kinase 1	Homo sapiens	28-31
19051078-7	2008	Both LY294002 and API-2, an Akt inhibitor, decreased the Bcl-2/Bax ratio in menadione-exposed myotubes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	BCL2 apoptosis regulator	Homo sapiens	57-62
19051078-7	2008	Both LY294002 and API-2, an Akt inhibitor, decreased the Bcl-2/Bax ratio in menadione-exposed myotubes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	BCL2 associated X, apoptosis regulator	Homo sapiens	63-66
18660450-8	2008	The blockade of Akt with LY-294002 (15 microM) or PKC with chelerythrine (10 microM) abolished the cardioprotection induced by H2S postconditioning.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-34	AKT serine/threonine kinase 1	Rattus norvegicus	16-19
18556224-5	2008	However, the alkaline phosphatase activity was decreased in a dose-response manner within 24 h. The effect of PRL on alkaline phosphatase was abolished by LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	prolactin	Homo sapiens	110-113
18691227-5	2008	Furthermore, the enhanced Akt phosphorylation induced by U0126 is inhibited by the PI3-kinase inhibitor LY294002, and is accompanied by the up-regulation of Ras activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	AKT serine/threonine kinase 1	Homo sapiens	26-29
18366089-9	2008	Furthermore, the PI3 kinase/AKT inhibitor, LY294002, and p38 inhibitor, SB 203580, prevented the hypoxia-mediated stabilisation of HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	131-141
18785877-9	2008	Also, treatment with LY294002 significantly inhibited expression of Bcl-2, but PD98059 showed no significant effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	BCL2, apoptosis regulator	Rattus norvegicus	68-73
18495839-7	2008	By contrast, U1026 had no effect on SS-14 inhibition of GH-stimulated IGF-I mRNA expression, whereas LY294002 partially blocked the inhibition of GH-stimulated IGF-I mRNA expression by SS-14.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	insulin-like growth factor I	Oncorhynchus mykiss	160-165
17403556-5	2008	Tau phosphorylation was blocked by the Src family tyrosine kinase inhibitor, 4-amino-5-(4-chlorophenyl)-7(t-butyl)pyrazol(3,4-D)pyramide (PP1), and by the phosphatidylinositol-3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	microtubule associated protein tau	Homo sapiens	0-3
19069650-6	2008	Pretreatment of BEAS-2B cells with the EGFR inhibitor PD153035 and the PI3K inhibitor LY294002 significantly blocked zinc sulfate-induced ICAM-1 expression, CONCLUSION: Zinc sulfate stimulation could activate the EGFR and the PI3K/Akt signaling pathway, further leading to upregulation of ICAM-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	intercellular adhesion molecule 1	Homo sapiens	138-144
19069650-6	2008	Pretreatment of BEAS-2B cells with the EGFR inhibitor PD153035 and the PI3K inhibitor LY294002 significantly blocked zinc sulfate-induced ICAM-1 expression, CONCLUSION: Zinc sulfate stimulation could activate the EGFR and the PI3K/Akt signaling pathway, further leading to upregulation of ICAM-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	epidermal growth factor receptor	Homo sapiens	213-217
19069650-6	2008	Pretreatment of BEAS-2B cells with the EGFR inhibitor PD153035 and the PI3K inhibitor LY294002 significantly blocked zinc sulfate-induced ICAM-1 expression, CONCLUSION: Zinc sulfate stimulation could activate the EGFR and the PI3K/Akt signaling pathway, further leading to upregulation of ICAM-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	AKT serine/threonine kinase 1	Homo sapiens	231-234
19069650-6	2008	Pretreatment of BEAS-2B cells with the EGFR inhibitor PD153035 and the PI3K inhibitor LY294002 significantly blocked zinc sulfate-induced ICAM-1 expression, CONCLUSION: Zinc sulfate stimulation could activate the EGFR and the PI3K/Akt signaling pathway, further leading to upregulation of ICAM-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	intercellular adhesion molecule 1	Homo sapiens	289-295
18621031-7	2008	LY 294002, a PI3 kinase inhibitor, blocked the GlyT1-mediated glycine uptake with an IC50 value of 81+/-2 microM, whereas another inhibitor wortmannin did not show any effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	solute carrier family 6 member 9	Homo sapiens	47-52
18621031-10	2008	These results suggest that the commonly used PI3 kinase blocker LY 294002 may modulate GlyT1 function independent of PI3 kinase inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	solute carrier family 6 member 9	Homo sapiens	87-92
18953090-5	2008	It was also shown that protective effects of DHEA, DHEAS and PGL against staurosporine-induced LDH release were attenuated by extracellular signal-regulated kinase (ERK)--mitogen-activated protein kinase (MAPK) inhibitor--PD 98059 (5 microM) but not by phosphatidylinositol-3-kinase (PI3-K) inhibitors such as LY 294002 (1 microM) or wortmannin (10 nM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	310-319	mitogen-activated protein kinase 1	Homo sapiens	126-163
18953090-5	2008	It was also shown that protective effects of DHEA, DHEAS and PGL against staurosporine-induced LDH release were attenuated by extracellular signal-regulated kinase (ERK)--mitogen-activated protein kinase (MAPK) inhibitor--PD 98059 (5 microM) but not by phosphatidylinositol-3-kinase (PI3-K) inhibitors such as LY 294002 (1 microM) or wortmannin (10 nM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	310-319	mitogen-activated protein kinase 1	Homo sapiens	165-168
18621031-0	2008	The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-53	solute carrier family 6 member 9	Homo sapiens	63-68
18676851-3	2008	Here, we report that inhibition of PI3K by LY294002 broadly sensitizes wild-type and mutant PTEN glioblastoma cells to both death receptor- and chemotherapy-induced apoptosis, whereas mammalian target of rapamycin (mTOR) inhibition is not sufficient to restore apoptosis sensitivity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	phosphatase and tensin homolog	Homo sapiens	92-96
18341625-3	2008	Also, the phosphorylation of ERK1/2 and Akt was detected by Western blotting, and specific inhibitors of mitogen-activated protein kinase (MAPK) (PD98059; 40 microm) and phosphatidylinositol 3-kinase (PI3-K, LY294002; 40 microm) were used to evaluate the role of these signalling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	mitogen-activated protein kinase 3	Homo sapiens	29-35
18341625-3	2008	Also, the phosphorylation of ERK1/2 and Akt was detected by Western blotting, and specific inhibitors of mitogen-activated protein kinase (MAPK) (PD98059; 40 microm) and phosphatidylinositol 3-kinase (PI3-K, LY294002; 40 microm) were used to evaluate the role of these signalling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	AKT serine/threonine kinase 1	Homo sapiens	40-43
18676830-9	2008	PTEN loss rendered cells significantly more sensitive to growth inhibition by the PI3K inhibitor LY294002 than did PIK3CA mutations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	phosphatase and tensin homolog	Homo sapiens	0-4
18677115-7	2008	Inhibitor studies using Roscovitine (CDK1 inhibitor), LY-294002 (PI3K inhibitor) and SH-6 (PKB inhibitor) reveal that activation of AURKA localized on MTOCs is independent on PI3K-PKB and CDK1 signaling pathways and MOTC amplification is observed in roscovitine- and SH-6-treated oocytes that fail to undergo nuclear envelope breakdown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-63	aurora kinase A	Mus musculus	132-137
18676851-3	2008	Here, we report that inhibition of PI3K by LY294002 broadly sensitizes wild-type and mutant PTEN glioblastoma cells to both death receptor- and chemotherapy-induced apoptosis, whereas mammalian target of rapamycin (mTOR) inhibition is not sufficient to restore apoptosis sensitivity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	mechanistic target of rapamycin kinase	Homo sapiens	215-219
18676851-4	2008	LY294002 significantly enhances apoptosis triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), agonistic anti-CD95 antibodies, or several anticancer drugs (i.e., doxorubicin, etoposide, and vincristine) in a highly synergistic manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	TNF superfamily member 10	Homo sapiens	55-110
18676851-4	2008	LY294002 significantly enhances apoptosis triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), agonistic anti-CD95 antibodies, or several anticancer drugs (i.e., doxorubicin, etoposide, and vincristine) in a highly synergistic manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	TNF superfamily member 10	Homo sapiens	112-117
18676851-4	2008	LY294002 significantly enhances apoptosis triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), agonistic anti-CD95 antibodies, or several anticancer drugs (i.e., doxorubicin, etoposide, and vincristine) in a highly synergistic manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Fas cell surface death receptor	Homo sapiens	135-139
18676851-5	2008	In addition, LY294002 cooperates with TRAIL or doxorubicin to suppress colony formation, thus also showing a strong effect on long-term survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	TNF superfamily member 10	Homo sapiens	38-43
18676851-9	2008	Most importantly, PI3K inhibition by LY294002 sensitizes primary cultured glioblastoma cells obtained from surgical specimens to TRAIL- or chemotherapy-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	TNF superfamily member 10	Homo sapiens	129-134
18797142-5	2008	When phosphatidylinositol 3-kinase (PI3K) pathway was inhibited by LY294002, the increase in collagen induced by ELF-EMF exposure was accelerated, however, the increase in collagen observed by IGF-I addition was suppressed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	insulin-like growth factor 1	Mus musculus	193-198
18691077-7	2008	Both endpoints were significantly reduced by the CK2 inhibitors 4,5,6,7-tetrabromobenzotriazole (TBB) and 2-dimethyl-amino-4,5,6,7-tetrabromo-1H-benzimidazole (DMAT), and by the PKC inhibitor GF109203X; the PI3K inhibitors LY294002 and wortmannin had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	223-231	casein kinase 2, alpha prime polypeptide	Mus musculus	49-52
18395956-10	2008	These pharmacological roles of LY294002 might be played through the PI3K/Akt/mTOR signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	73-76
18395956-10	2008	These pharmacological roles of LY294002 might be played through the PI3K/Akt/mTOR signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	mechanistic target of rapamycin kinase	Homo sapiens	77-81
18269934-12	2008	SNP and LY294002, a PI3-K inhibitor, both caused a significant rise in caspase 3 release from NOKs which was reduced in the presence of IGFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	caspase 3	Homo sapiens	71-80
18288489-6	2008	RESULTS: Co-treatment of NB4 cells with either LY294002 to inhibit PI3Ks or PD98059 in order to suppress MEK activity led to significant reduction of CD11b surface expression during ATRA, 9cisRA or the RAR alpha agonist Ro40-6055 dependent NB4 cells granulocyte differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	mitogen-activated protein kinase kinase 7	Homo sapiens	105-108
18288489-6	2008	RESULTS: Co-treatment of NB4 cells with either LY294002 to inhibit PI3Ks or PD98059 in order to suppress MEK activity led to significant reduction of CD11b surface expression during ATRA, 9cisRA or the RAR alpha agonist Ro40-6055 dependent NB4 cells granulocyte differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	integrin subunit alpha M	Homo sapiens	150-155
18288489-6	2008	RESULTS: Co-treatment of NB4 cells with either LY294002 to inhibit PI3Ks or PD98059 in order to suppress MEK activity led to significant reduction of CD11b surface expression during ATRA, 9cisRA or the RAR alpha agonist Ro40-6055 dependent NB4 cells granulocyte differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	retinoic acid receptor alpha	Homo sapiens	202-211
18366086-5	2008	Using the small molecule inhibitor LY-294002 that inhibits both mTOR and PI 3-kinase, we demonstrated that kinase activity was required for epithelial remodeling, disruption of cell junctions and subsequent modulation of tubule formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-44	mechanistic target of rapamycin kinase	Canis lupus familiaris	64-68
19383336-3	2008	In both immortalized normal (TIOSE) and ovarian carcinoma cell lines (OVCA), SnoN RNA levels were increased by TGFbeta stimulation and altered by LY294002 and JNK II inhibitor treatment suggesting that the PI3K and JNK signaling pathways may regulate TGFbeta-induced increases in SnoN RNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	SKI like proto-oncogene	Homo sapiens	77-81
18586515-5	2008	EPO stimulated the phosphorylation of Akt at serine-473 and co-incubation of the Akt/PI-3 kinase pathway inhibitor LY294002 with EPO abolished its effects on Akt phosphorylation and axonal growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	erythropoietin	Homo sapiens	0-3
18586515-5	2008	EPO stimulated the phosphorylation of Akt at serine-473 and co-incubation of the Akt/PI-3 kinase pathway inhibitor LY294002 with EPO abolished its effects on Akt phosphorylation and axonal growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	AKT serine/threonine kinase 1	Homo sapiens	38-41
18586515-5	2008	EPO stimulated the phosphorylation of Akt at serine-473 and co-incubation of the Akt/PI-3 kinase pathway inhibitor LY294002 with EPO abolished its effects on Akt phosphorylation and axonal growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	AKT serine/threonine kinase 1	Homo sapiens	81-84
18586515-5	2008	EPO stimulated the phosphorylation of Akt at serine-473 and co-incubation of the Akt/PI-3 kinase pathway inhibitor LY294002 with EPO abolished its effects on Akt phosphorylation and axonal growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	erythropoietin	Homo sapiens	129-132
18586515-5	2008	EPO stimulated the phosphorylation of Akt at serine-473 and co-incubation of the Akt/PI-3 kinase pathway inhibitor LY294002 with EPO abolished its effects on Akt phosphorylation and axonal growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	AKT serine/threonine kinase 1	Homo sapiens	81-84
18788932-8	2008	Moreover, the pERK1/2 and pAkt upregulation induced by FGF-2 and -4 were completely abolished by treatment with the MEK1/2 inhibitor, U0126 and the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	fibroblast growth factor 2	Homo sapiens	55-67
18788932-8	2008	Moreover, the pERK1/2 and pAkt upregulation induced by FGF-2 and -4 were completely abolished by treatment with the MEK1/2 inhibitor, U0126 and the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	mitogen-activated protein kinase kinase 1	Homo sapiens	116-122
18690350-14	2008	The inhibitory effect of Adp on TNF-alpha-induced TF synthesis was abrogated in part by pretreatment with the PI3kinase inhibitor LY294002, suggesting that Akt activation might inhibit TF expression induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	adiponectin, C1Q and collagen domain containing	Homo sapiens	25-28
18766138-7	2008	RESULTS: Treatment of alphaT3-1 cells with PI3-kinase inhibitor, LY 294002, significantly increased alpha-subunit gene expression up to 6.89 +/- 0.26-fold, and showed additive effect with gonadotropin-releasing hormone (GnRH).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-74	gonadotropin releasing hormone 1	Mus musculus	188-218
18766138-7	2008	RESULTS: Treatment of alphaT3-1 cells with PI3-kinase inhibitor, LY 294002, significantly increased alpha-subunit gene expression up to 6.89 +/- 0.26-fold, and showed additive effect with gonadotropin-releasing hormone (GnRH).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-74	gonadotropin releasing hormone 1	Mus musculus	220-224
18766138-11	2008	Western blotting analysis using phosphorylated form specific antibody for ERK demonstrated that both LY 294002 and wortmannin increased ERK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-110	mitogen-activated protein kinase 1	Mus musculus	74-77
18766138-11	2008	Western blotting analysis using phosphorylated form specific antibody for ERK demonstrated that both LY 294002 and wortmannin increased ERK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-110	mitogen-activated protein kinase 1	Mus musculus	136-139
18766138-12	2008	CONCLUSION: These results suggested that PI3-kinase inhibitor, LY 294002 and wortmannin increased gonadotropin alpha-subunit gene expression related with ERK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-72	mitogen-activated protein kinase 1	Mus musculus	154-157
18670641-4	2008	On the basis of gene expression array studies, we identified Aurora A as one of the genes regulated transcriptionally by Akt inhibitors including Compound A. Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, either by PI3K inhibitor LY294002 or by Compound A, dramatically inhibits the promoter activity of Aurora A, whereas the mammalian target of rapamycin inhibitor has little effect, suggesting that Akt might be responsible for up-regulating Aurora A for mitotic progression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	aurora kinase A	Homo sapiens	61-69
18670641-4	2008	On the basis of gene expression array studies, we identified Aurora A as one of the genes regulated transcriptionally by Akt inhibitors including Compound A. Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, either by PI3K inhibitor LY294002 or by Compound A, dramatically inhibits the promoter activity of Aurora A, whereas the mammalian target of rapamycin inhibitor has little effect, suggesting that Akt might be responsible for up-regulating Aurora A for mitotic progression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	AKT serine/threonine kinase 1	Homo sapiens	121-124
18670641-4	2008	On the basis of gene expression array studies, we identified Aurora A as one of the genes regulated transcriptionally by Akt inhibitors including Compound A. Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, either by PI3K inhibitor LY294002 or by Compound A, dramatically inhibits the promoter activity of Aurora A, whereas the mammalian target of rapamycin inhibitor has little effect, suggesting that Akt might be responsible for up-regulating Aurora A for mitotic progression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	176-205
18670641-4	2008	On the basis of gene expression array studies, we identified Aurora A as one of the genes regulated transcriptionally by Akt inhibitors including Compound A. Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, either by PI3K inhibitor LY294002 or by Compound A, dramatically inhibits the promoter activity of Aurora A, whereas the mammalian target of rapamycin inhibitor has little effect, suggesting that Akt might be responsible for up-regulating Aurora A for mitotic progression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	AKT serine/threonine kinase 1	Homo sapiens	213-216
18670641-4	2008	On the basis of gene expression array studies, we identified Aurora A as one of the genes regulated transcriptionally by Akt inhibitors including Compound A. Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, either by PI3K inhibitor LY294002 or by Compound A, dramatically inhibits the promoter activity of Aurora A, whereas the mammalian target of rapamycin inhibitor has little effect, suggesting that Akt might be responsible for up-regulating Aurora A for mitotic progression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	AKT serine/threonine kinase 1	Homo sapiens	213-216
18690350-14	2008	The inhibitory effect of Adp on TNF-alpha-induced TF synthesis was abrogated in part by pretreatment with the PI3kinase inhibitor LY294002, suggesting that Akt activation might inhibit TF expression induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	tumor necrosis factor	Homo sapiens	32-41
18690350-14	2008	The inhibitory effect of Adp on TNF-alpha-induced TF synthesis was abrogated in part by pretreatment with the PI3kinase inhibitor LY294002, suggesting that Akt activation might inhibit TF expression induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	AKT serine/threonine kinase 1	Homo sapiens	156-159
18690350-14	2008	The inhibitory effect of Adp on TNF-alpha-induced TF synthesis was abrogated in part by pretreatment with the PI3kinase inhibitor LY294002, suggesting that Akt activation might inhibit TF expression induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	tumor necrosis factor	Homo sapiens	210-219
19102980-11	2008	(3) Low level of p38 induced by burn serum was increased after treatment of LY294002, which neutralized the protection of insulin (P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	mitogen-activated protein kinase 14	Mus musculus	17-20
18391984-8	2008	Finally, LNCaP cells are sensitized to TRAIL-induced apoptosis by PTEN or LY294002, and rescued by androgens.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	TNF superfamily member 10	Homo sapiens	39-44
19080430-11	2008	The proliferation and IL-6 and IL-10 secretion of the T cells from SLE patients cultured with LY294002 were inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	interleukin 6	Homo sapiens	22-26
19080430-11	2008	The proliferation and IL-6 and IL-10 secretion of the T cells from SLE patients cultured with LY294002 were inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	interleukin 10	Homo sapiens	31-36
18652687-5	2008	These profiles were further correlated with gene expression alterations caused by inhibition of PI3K/mTOR pathway with PI3K inhibitor Ly294002 or mTOR inhibitor rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	mechanistic target of rapamycin kinase	Homo sapiens	101-105
18466761-6	2008	IGF-1"s effect on beta-catenin expression was abolished by the presence of PI3-kinase inhibitor LY294002 or in ASCs transfected with Sfrp2 siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	insulin like growth factor 1	Homo sapiens	0-5
18468510-5	2008	The preincubation of NK cells with an ERK inhibitor (PD98059) or phosphoinositide-3-kinase (PI3K) inhibitors (wortmannin and LY294002) completely inhibited LPG-induced chemotactic migration, suggesting the essential role of ERK and PI3K in the process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	mitogen-activated protein kinase 1	Homo sapiens	224-227
18466761-6	2008	IGF-1"s effect on beta-catenin expression was abolished by the presence of PI3-kinase inhibitor LY294002 or in ASCs transfected with Sfrp2 siRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	catenin beta 1	Homo sapiens	18-30
18497334-12	2008	Furthermore, CO-induced NF-kappaB activation is reversed by phosphatidylinositol 3-kinase (PI3-K) inhibitor (LY294002) or antioxidants.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	60-89
18480058-9	2008	Moreover, the phosphatidyl inositide 3-kinase inhibitor LY294002 antagonized the effect of epinephrine combined with thrombin or AYPGKF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	coagulation factor II, thrombin	Homo sapiens	117-125
18492769-7	2008	Elevations in glycolytic flux produced by either glucagon (10(-10) M) or insulin (4 x 10(-10) M) were abolished by the phosphoinositide 3-kinase (PI3K) inhibitor LY-294002 (10 microM) but not significantly affected by NKY80.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-171	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	119-144
18456663-4	2008	Inactivation of Hsp90 by geldanamycin led to decreased SGK-1 phosphorylation independently of increased proteasomal protein degradation, and inhibition of PI3K activity by LY294002 appeared to eliminate SGK-1 phosphorylation at the same residues as those affected by geldanamycin treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	serum/glucocorticoid regulated kinase 1	Homo sapiens	203-208
18560380-7	2008	Moreover, both LY294002 and wortmannin abolished the anti-apoptotic effect of AngII.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	angiotensinogen	Rattus norvegicus	78-83
18491231-7	2008	Furthermore, DAP5/p97 expression was upregulated by inhibition of the PI3K/Akt/mammalian target of rapamycin (mTOR) pathway via LY294002 and via rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	eukaryotic translation initiation factor 4 gamma 2	Homo sapiens	13-17
18491231-7	2008	Furthermore, DAP5/p97 expression was upregulated by inhibition of the PI3K/Akt/mammalian target of rapamycin (mTOR) pathway via LY294002 and via rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	eukaryotic translation initiation factor 4 gamma 2	Homo sapiens	18-21
18491231-7	2008	Furthermore, DAP5/p97 expression was upregulated by inhibition of the PI3K/Akt/mammalian target of rapamycin (mTOR) pathway via LY294002 and via rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	AKT serine/threonine kinase 1	Homo sapiens	75-78
18491231-7	2008	Furthermore, DAP5/p97 expression was upregulated by inhibition of the PI3K/Akt/mammalian target of rapamycin (mTOR) pathway via LY294002 and via rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	mechanistic target of rapamycin kinase	Homo sapiens	79-108
18491231-7	2008	Furthermore, DAP5/p97 expression was upregulated by inhibition of the PI3K/Akt/mammalian target of rapamycin (mTOR) pathway via LY294002 and via rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	mechanistic target of rapamycin kinase	Homo sapiens	110-114
18434090-9	2008	In contrast, TGF-beta1-induced type I procollagen expression was decreased by Akt siRNA transfection and the PI3-kinase inhibitor, LY294002, inhibited the TGF-beta1-induced type I procollagen expression and also inhibited the cav-1-induced expression of type I procollagen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	transforming growth factor beta 1	Homo sapiens	13-22
18434090-9	2008	In contrast, TGF-beta1-induced type I procollagen expression was decreased by Akt siRNA transfection and the PI3-kinase inhibitor, LY294002, inhibited the TGF-beta1-induced type I procollagen expression and also inhibited the cav-1-induced expression of type I procollagen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	transforming growth factor beta 1	Homo sapiens	155-164
18434090-9	2008	In contrast, TGF-beta1-induced type I procollagen expression was decreased by Akt siRNA transfection and the PI3-kinase inhibitor, LY294002, inhibited the TGF-beta1-induced type I procollagen expression and also inhibited the cav-1-induced expression of type I procollagen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	collagen type I alpha 2 chain	Homo sapiens	173-191
18434090-9	2008	In contrast, TGF-beta1-induced type I procollagen expression was decreased by Akt siRNA transfection and the PI3-kinase inhibitor, LY294002, inhibited the TGF-beta1-induced type I procollagen expression and also inhibited the cav-1-induced expression of type I procollagen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	caveolin 1	Homo sapiens	226-231
18434090-9	2008	In contrast, TGF-beta1-induced type I procollagen expression was decreased by Akt siRNA transfection and the PI3-kinase inhibitor, LY294002, inhibited the TGF-beta1-induced type I procollagen expression and also inhibited the cav-1-induced expression of type I procollagen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	collagen type I alpha 2 chain	Homo sapiens	173-191
18574502-6	2008	Pretreatment with LY294002, a phosphoinositide 3-kinase (PI3K)/AKT inhibitor, neutralized the enhanced expression of survivin induced by FSH, but treatment with U0126, a mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor, had no such effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	30-55
18346168-6	2008	The protection afforded by Epo pretreatment was abolished by coinfusion of 5 micromol/L LY294002, a phosphatidylinositol 3-kinase (PI3-K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	erythropoietin	Rattus norvegicus	27-30
18346168-6	2008	The protection afforded by Epo pretreatment was abolished by coinfusion of 5 micromol/L LY294002, a phosphatidylinositol 3-kinase (PI3-K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	100-129
18574502-6	2008	Pretreatment with LY294002, a phosphoinositide 3-kinase (PI3K)/AKT inhibitor, neutralized the enhanced expression of survivin induced by FSH, but treatment with U0126, a mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor, had no such effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	63-66
18379876-4	2008	Akt1 activation promoted cell survival, because the phosphatidylinositol 3-kinase(PI3K) inhibitor LY294002 inhibited Akt1 phosphorylation and inhibited cell growth, especially in cells with active Akt1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	AKT serine/threonine kinase 1	Homo sapiens	0-4
18707587-5	2008	Inhibition of activity of these kinases by treatment of cells with PI-3K/Akt-specific inhibitor LY294002 or Erk-specific inhibitor PD98059 resulted in inhibition of MMP-2 expression and the decrease of invasion in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	AKT serine/threonine kinase 1	Homo sapiens	73-76
18707587-5	2008	Inhibition of activity of these kinases by treatment of cells with PI-3K/Akt-specific inhibitor LY294002 or Erk-specific inhibitor PD98059 resulted in inhibition of MMP-2 expression and the decrease of invasion in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	matrix metallopeptidase 2	Homo sapiens	165-170
18379876-4	2008	Akt1 activation promoted cell survival, because the phosphatidylinositol 3-kinase(PI3K) inhibitor LY294002 inhibited Akt1 phosphorylation and inhibited cell growth, especially in cells with active Akt1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	AKT serine/threonine kinase 1	Homo sapiens	117-121
18379876-4	2008	Akt1 activation promoted cell survival, because the phosphatidylinositol 3-kinase(PI3K) inhibitor LY294002 inhibited Akt1 phosphorylation and inhibited cell growth, especially in cells with active Akt1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	AKT serine/threonine kinase 1	Homo sapiens	117-121
18578689-5	2008	The phosphorylation of eNOS is Akt-dependent and completely reverted by the phosphatidylinositol-3 kinase (PI-3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	nitric oxide synthase 3	Homo sapiens	23-27
18356276-9	2008	Indeed, TRbeta(PV/PV) mice treated with a PI3K-specific inhibitor, LY294002, showed a significant decrease in pituitary growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	thyroid hormone receptor beta	Mus musculus	8-14
18356276-10	2008	The progrowth signaling via AKT-mammalian target rapamycin-p70(S6K) and cyclin D1/cyclin-dependent kinase were inhibited, and proapoptotic activity of Bcl-2-associated death promoter was increased by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	thymoma viral proto-oncogene 1	Mus musculus	28-31
18356276-10	2008	The progrowth signaling via AKT-mammalian target rapamycin-p70(S6K) and cyclin D1/cyclin-dependent kinase were inhibited, and proapoptotic activity of Bcl-2-associated death promoter was increased by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	ribosomal protein S6 kinase B1	Homo sapiens	49-52
18356276-10	2008	The progrowth signaling via AKT-mammalian target rapamycin-p70(S6K) and cyclin D1/cyclin-dependent kinase were inhibited, and proapoptotic activity of Bcl-2-associated death promoter was increased by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	cyclin D1	Homo sapiens	72-81
18356276-10	2008	The progrowth signaling via AKT-mammalian target rapamycin-p70(S6K) and cyclin D1/cyclin-dependent kinase were inhibited, and proapoptotic activity of Bcl-2-associated death promoter was increased by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	BCL2 apoptosis regulator	Homo sapiens	151-156
18578689-5	2008	The phosphorylation of eNOS is Akt-dependent and completely reverted by the phosphatidylinositol-3 kinase (PI-3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	76-105
17868340-6	2008	Phosphatidylinositol 3-kinase inhibition by LY294002 also enhanced TRAIL-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	TNF superfamily member 10	Homo sapiens	67-72
18589211-11	2008	Protein expressions of ATM and ATR downstream effectors showed no differences among the treated groups, however, DNA-PK activity was significantly inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	ATM serine/threonine kinase	Homo sapiens	23-26
18589211-11	2008	Protein expressions of ATM and ATR downstream effectors showed no differences among the treated groups, however, DNA-PK activity was significantly inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	ATR serine/threonine kinase	Homo sapiens	31-34
18589211-11	2008	Protein expressions of ATM and ATR downstream effectors showed no differences among the treated groups, however, DNA-PK activity was significantly inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	113-119
18589211-12	2008	CONCLUSIONS: These results lead us to conclude that the central mechanism by which LY294002 radiosensitizes is via DNA-PK inhibition which induces DNA double-strand break repair inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	115-121
17868340-7	2008	Further decreased Akt activity by LY294002 in detached cells translated to increased cell death after TRAIL treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	18-21
17868340-7	2008	Further decreased Akt activity by LY294002 in detached cells translated to increased cell death after TRAIL treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	TNF superfamily member 10	Homo sapiens	102-107
18419760-10	2008	MAPK (PD98059) and PI3K (LY294002) inhibitors fully prevented activation of GFAP gene promoter by all treatments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	glial fibrillary acidic protein	Mus musculus	76-80
18467363-5	2008	Depleters of tissue PIP(2) wortmannin and LY294002 stimulated TRPC6 activity, as did the polycation PIP(2) scavenger poly-L-lysine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	short transient receptor potential channel 6	Oryctolagus cuniculus	62-67
18622747-10	2008	Phosphorylation of Akt, p70S6K and 4E-BP1 were significantly reduced in the cells treated with LY294002 or RAPA (P&lt;0.01), but we failed to find that 5-aza-dC enhance these effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	19-22
18161870-9	2008	The OBCM-mediated increases in IKK alpha/beta phosphorylation, p65 Ser(536) phosphorylation, and kappaB-luciferase activity were inhibited by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	31-40
18161870-9	2008	The OBCM-mediated increases in IKK alpha/beta phosphorylation, p65 Ser(536) phosphorylation, and kappaB-luciferase activity were inhibited by LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	RELA proto-oncogene, NF-kB subunit	Homo sapiens	63-66
18622747-10	2008	Phosphorylation of Akt, p70S6K and 4E-BP1 were significantly reduced in the cells treated with LY294002 or RAPA (P&lt;0.01), but we failed to find that 5-aza-dC enhance these effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	ribosomal protein S6 kinase B1	Homo sapiens	24-41
18332867-5	2008	In mechanistic studies identifying AR degradation, isosilybin B caused increased phosphorylation of Akt (Ser-473 and Thr-308) and Mdm2 (Ser-166), which was linked with AR degradation as pretreatment with PI3K inhibitor (LY294002)-restored AR level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	AKT serine/threonine kinase 1	Homo sapiens	100-103
18598766-6	2008	PI3K inhibitor LY294002 could block the elevation of HO-1 protein expression and reverse the protective effect of alpha-Gal silencing and GS-IB4 against CDC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	heme oxygenase 1	Homo sapiens	53-57
19100095-9	2008	The effects of EPO on eNOS and NO could be blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	erythropoietin	Rattus norvegicus	15-18
19100095-11	2008	The suppression effects on expressions of TGF-beta1 and collagen by Ang II in CFs were blocked by both LY294002 and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	transforming growth factor, beta 1	Rattus norvegicus	42-51
19100095-11	2008	The suppression effects on expressions of TGF-beta1 and collagen by Ang II in CFs were blocked by both LY294002 and L-NAME.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	angiotensinogen	Rattus norvegicus	68-74
18633459-5	2008	Consistently, Akt activation was completely abolished in an SS cell line assay when stimulated by PDGF-AA and treated with the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	AKT serine/threonine kinase 1	Homo sapiens	14-17
18307411-9	2008	Nedd4 expression was also decreased by a PI3K (phosphoinositide 3-kinase) inhibitor, LY294002, suggesting that the regulation is dependent on the phosphatase-kinase activity of the PTEN-PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	0-5
18340006-4	2008	This effect and the activation of the EphB4 promoter were mediated by the phosphatidylinositol-3-kinase (P13-K)/Akt pathway and sensitive to the P13-K inhibitor LY 294002 as well as to simultaneous transfection with dominant-negative Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-170	Eph receptor B4	Mus musculus	38-43
18535744-8	2008	LY294002, a phosphatidylinositol-3 kinase inhibitor, could prevent the increase of permeability of GEnCs induced by Angptl3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	angiopoietin like 3	Homo sapiens	116-123
18340006-4	2008	This effect and the activation of the EphB4 promoter were mediated by the phosphatidylinositol-3-kinase (P13-K)/Akt pathway and sensitive to the P13-K inhibitor LY 294002 as well as to simultaneous transfection with dominant-negative Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-170	thymoma viral proto-oncogene 1	Mus musculus	234-237
18307411-9	2008	Nedd4 expression was also decreased by a PI3K (phosphoinositide 3-kinase) inhibitor, LY294002, suggesting that the regulation is dependent on the phosphatase-kinase activity of the PTEN-PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	phosphatase and tensin homolog	Homo sapiens	181-185
18307411-9	2008	Nedd4 expression was also decreased by a PI3K (phosphoinositide 3-kinase) inhibitor, LY294002, suggesting that the regulation is dependent on the phosphatase-kinase activity of the PTEN-PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Homo sapiens	191-194
18499442-7	2008	The combination of dexamethasone (Dex) and LY294002, wortmannin, triciribine, or AKT inhibitor VIII dramatically up regulated GILZ levels and enhanced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	TSC22 domain family member 3	Homo sapiens	126-130
18372159-7	2008	Both LY294002 and PD98059 attenuated mOSM-induced phosphorylation of ERK1/2 MAP kinase and also reduced binding of an AP-1 responsive promoter element, a transcriptional complex known to be MAPK-sensitive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	mitogen-activated protein kinase 3	Mus musculus	69-75
18372159-7	2008	Both LY294002 and PD98059 attenuated mOSM-induced phosphorylation of ERK1/2 MAP kinase and also reduced binding of an AP-1 responsive promoter element, a transcriptional complex known to be MAPK-sensitive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	mitogen-activated protein kinase 1	Mus musculus	190-194
18372159-8	2008	Further, LY294002 pretreatment reduced mOSM-stimulated expression of the downstream AP-1 co-factor JunB, while PD98059 reduced levels of JunB as well as c-Fos.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	jun B proto-oncogene	Mus musculus	99-103
18383341-9	2008	The LPS-induced increase of mPGES-1 was inhibited by different signaling pathway inhibitors, such as SP600125, LY294002, GF109203X, and SC-514, suggesting the involvement of c-Jun N-terminal kinase (JNK), phosphatidylinositol 3-kinase (PI-3K)/Akt, protein kinase C (PKC) pathways, and the nuclear factor (NF)-kappaB, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	prostaglandin E synthase	Mus musculus	28-35
18383341-9	2008	The LPS-induced increase of mPGES-1 was inhibited by different signaling pathway inhibitors, such as SP600125, LY294002, GF109203X, and SC-514, suggesting the involvement of c-Jun N-terminal kinase (JNK), phosphatidylinositol 3-kinase (PI-3K)/Akt, protein kinase C (PKC) pathways, and the nuclear factor (NF)-kappaB, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	mitogen-activated protein kinase 8	Rattus norvegicus	174-197
18383341-10	2008	In contrast to other reports, LPS-induced mPGES-1 synthesis was not invariably coupled to the synthesis of COX-2, since inhibition of PI-3K with LY294002 decreased mPGES-1 but increased COX-2 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	prostaglandin E synthase	Mus musculus	164-171
18383341-10	2008	In contrast to other reports, LPS-induced mPGES-1 synthesis was not invariably coupled to the synthesis of COX-2, since inhibition of PI-3K with LY294002 decreased mPGES-1 but increased COX-2 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	186-191
18064631-7	2008	Investigation of signaling intermediates revealed that IL-18 stimulated PI3 kinase activity (blocked by wortmannin, LY294002, or Ad.dnPI3Kp85), and Akt phosphorylation and kinase activity (blocked by SH-5 or Ad.dnAkt).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	interleukin 18	Homo sapiens	55-60
18343694-5	2008	Furthermore, in detached A549 cells, increased FAK phosphorylations (Tyr397, Tyr861, Tyr925) were detected in a time-dependent manner, and the specific inhibitors of MEK1, PI3K, and Src (PD98059, LY294002, and PP2) partly abolished the resistance to the anoikis characteristic of cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	protein tyrosine kinase 2	Homo sapiens	47-50
18343694-5	2008	Furthermore, in detached A549 cells, increased FAK phosphorylations (Tyr397, Tyr861, Tyr925) were detected in a time-dependent manner, and the specific inhibitors of MEK1, PI3K, and Src (PD98059, LY294002, and PP2) partly abolished the resistance to the anoikis characteristic of cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	mitogen-activated protein kinase kinase 1	Homo sapiens	166-170
18343694-5	2008	Furthermore, in detached A549 cells, increased FAK phosphorylations (Tyr397, Tyr861, Tyr925) were detected in a time-dependent manner, and the specific inhibitors of MEK1, PI3K, and Src (PD98059, LY294002, and PP2) partly abolished the resistance to the anoikis characteristic of cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	182-185
18163394-7	2008	PI3K inhibitor (LY294002) and ERK inhibitor (PD98059) significantly reversed the protective effects of Bcl-x(L) on staurosporine-induced hepatocyte death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	Bcl2-like 1	Rattus norvegicus	103-111
18498889-9	2008	Selective inhibitors of the ERK (PD98059) and AKT (LY294002) pathways amplified HPC cell damage after HEMA exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	46-49
18190961-7	2008	The Abl kinase inhibitors and PI3K inhibitor, LY294002, induced the expression of HOXA10, and it enhanced apoptosis in CML cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	homeobox A10	Homo sapiens	82-88
18190961-8	2008	Moreover, the reduction of HOXA10 expression by siRNA in CML cells inhibited apoptosis by treatment with the Abl kinase inhibitors and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	homeobox A10	Homo sapiens	27-33
18190961-11	2008	This study shows for the first time that the Abl kinase inhibitor and LY294002 induced HOXA10, and HOXA10 had an important role in apoptosis or cell growth inhibition in CML cells in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	homeobox A10	Homo sapiens	87-93
18190961-11	2008	This study shows for the first time that the Abl kinase inhibitor and LY294002 induced HOXA10, and HOXA10 had an important role in apoptosis or cell growth inhibition in CML cells in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	homeobox A10	Homo sapiens	99-105
18295594-8	2008	However, pretreatment with PD98059 and LY294002 (ERK1/2 and Akt inhibitors) inhibited MT-III-induced stimulation of HIF-1alpha protein expression and VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	hypoxia inducible factor 1, alpha subunit	Mus musculus	116-126
18041768-6	2008	Pretreatment of cells with LY294002, a PI3K inhibitor, significantly inhibited MMP-9 protein expression in FGF-1-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	matrix metallopeptidase 9	Rattus norvegicus	79-84
18041768-6	2008	Pretreatment of cells with LY294002, a PI3K inhibitor, significantly inhibited MMP-9 protein expression in FGF-1-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	fibroblast growth factor 1	Rattus norvegicus	107-112
18058806-2	2008	We investigated the expression of activated Akt (p-Akt) and mTOR (p-mTOR) in patients with adenocarcinoma of the cervix and the involvement of the p-Akt/p-mTOR pathway in response to combination of inhibitor agents, rapamycin and LY294002, with conventional therapy, cisplatin, in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	230-238	AKT serine/threonine kinase 1	Homo sapiens	44-47
18349105-6	2008	We observe here that treatment with LY294002 reduces migration of HRG-stimulated cells but not EGF-stimulated cells, despite comparable levels of reduction of Akt phosphorylation under both conditions, demonstrating that the target inhibition effect is not unilaterally predictive of efficacy against cell phenotypic response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	159-162
18410948-6	2008	PI-3K inhibitor LY294002 reversed the increasing Akt activation and ASK1 (S83) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Rattus norvegicus	49-52
18410948-6	2008	PI-3K inhibitor LY294002 reversed the increasing Akt activation and ASK1 (S83) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	68-72
18332139-3	2008	Inhibition of PI3-kinase by LY294002 prevents spheroid formation by degrading E-cadherin and beta-catenin, blocking transdifferentiation into insulin-secreting cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cadherin 1	Homo sapiens	78-88
18332139-3	2008	Inhibition of PI3-kinase by LY294002 prevents spheroid formation by degrading E-cadherin and beta-catenin, blocking transdifferentiation into insulin-secreting cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	catenin beta 1	Homo sapiens	93-105
18214988-4	2008	After OGD incubation, OLG cultures were divided into the following groups: 1) OGD alone, 2) OLG cocultured with BMSCs, 3) treatment with the phosphoinostide 3-kinase (PI3k) inhibitor LY294002, 4) LY294002-treated OLGs with BMSC cocultured, and 5) anti-p75 antibody-treated OLGs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	141-165
18418254-5	2008	Exogenous HGF-induced proliferation was inhibited by U0126, whereas migration was completely blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	hepatocyte growth factor	Homo sapiens	10-13
18295594-8	2008	However, pretreatment with PD98059 and LY294002 (ERK1/2 and Akt inhibitors) inhibited MT-III-induced stimulation of HIF-1alpha protein expression and VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	mitogen-activated protein kinase 3	Mus musculus	49-55
18295594-8	2008	However, pretreatment with PD98059 and LY294002 (ERK1/2 and Akt inhibitors) inhibited MT-III-induced stimulation of HIF-1alpha protein expression and VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	thymoma viral proto-oncogene 1	Mus musculus	60-63
18295594-8	2008	However, pretreatment with PD98059 and LY294002 (ERK1/2 and Akt inhibitors) inhibited MT-III-induced stimulation of HIF-1alpha protein expression and VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	metallothionein 3	Mus musculus	86-92
18332138-5	2008	Inhibition of PI3K signaling using LY294002 blocked IL-1+OSM-mediated Akt phosphorylation, induction of MMP-1 and MMP-13, and cartilage collagenolysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	interleukin 1 alpha	Homo sapiens	52-60
18332138-5	2008	Inhibition of PI3K signaling using LY294002 blocked IL-1+OSM-mediated Akt phosphorylation, induction of MMP-1 and MMP-13, and cartilage collagenolysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	70-73
18332138-5	2008	Inhibition of PI3K signaling using LY294002 blocked IL-1+OSM-mediated Akt phosphorylation, induction of MMP-1 and MMP-13, and cartilage collagenolysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	matrix metallopeptidase 1	Homo sapiens	104-109
18332138-5	2008	Inhibition of PI3K signaling using LY294002 blocked IL-1+OSM-mediated Akt phosphorylation, induction of MMP-1 and MMP-13, and cartilage collagenolysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	matrix metallopeptidase 13	Homo sapiens	114-120
18353772-5	2008	KLF8 promoter activity and mRNA levels are induced by expression of constitutively active (CA) phosphatidylinositol 3-kinase (PI3K) or CA-Akt but are repressed by dominant negative Akt or the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	Kruppel like factor 8	Homo sapiens	0-4
18295594-8	2008	However, pretreatment with PD98059 and LY294002 (ERK1/2 and Akt inhibitors) inhibited MT-III-induced stimulation of HIF-1alpha protein expression and VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	vascular endothelial growth factor A	Mus musculus	150-154
18375256-9	2008	AKT and eNOS inhibitor, LY294002 and L-NAME, respectively, augmented palmitic and linoleic acids inhibitory effects on EPCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	0-3
18326492-6	2008	The Arf6-GTP decrease in convulxin-stimulated platelets showed similar requirements and was also sensitive to piceatannol, wortmannin, and LY294002, indicating additional requirements for Syk and phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	ADP ribosylation factor 6	Homo sapiens	4-8
18367589-8	2008	The data illustrated that PD-98059, a MEK (MAPK kinase) inhibitor, LY-294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, and H-89, a protein kinase A (PKA) inhibitor, substantially decreased the induction of ODC catalytic activity and ODC mRNA expression induced by IL-4 and IL-13, suggesting positive regulation of the ODC gene by ERK, PI3K, and PKA pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-76	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	80-109
18080832-6	2008	We found that administration of various apoptosis inducing agents and conditions (serum starvation, anisomycin, LY294002, etoposide, and cisplatin) led to the proteolytic cleavage of PKR in PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	eukaryotic translation initiation factor 2-alpha kinase 2	Rattus norvegicus	183-186
18385910-10	2008	Extracellular regulated kinase (ERK) 1/2 inhibitor (U0126) or phosphoinositide kinase-3 (PI3K) inhibitor (LY294002) could partially block the response of Hsp105 and Hsp70 induced by heat treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	heat shock protein family H (Hsp110) member 1	Homo sapiens	154-160
18385910-10	2008	Extracellular regulated kinase (ERK) 1/2 inhibitor (U0126) or phosphoinositide kinase-3 (PI3K) inhibitor (LY294002) could partially block the response of Hsp105 and Hsp70 induced by heat treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	heat shock protein family A (Hsp70) member 4	Homo sapiens	165-170
18276108-11	2008	PI3K/Akt inhibitor LY294002 blocked roflumilast-induced Akt phosphorylation and protective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Rattus norvegicus	5-8
18080084-9	2008	LY294002 abolished the metformin-induced Akt phosphorylation and the infarct-limiting effect of metformin in Wistar (61 +/- 6.7% metformin + LY294002 vs. 35 +/- 2.7% metformin: P &lt; 0.05) and GK rats (56 +/- 5.7% metformin + LY294002 vs. 43 +/- 4.7% metformin: P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
18262389-8	2008	Inhibiting Akt activity with the phosphoinositide-3-kinase inhibitor LY294002 or Akt inhibitor X suppressed HGF-induced phosphorylation of GSK-3beta, increased MAP2 phosphorylation, and blocked the ability of HGF to enhance dendritic length.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	11-14
18276108-11	2008	PI3K/Akt inhibitor LY294002 blocked roflumilast-induced Akt phosphorylation and protective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Rattus norvegicus	56-59
18080832-10	2008	The activation of caspase-3 preceded the cleavage of PKR after serum withdrawal, anisomycin and etoposide treatment, while coincided with it in cells treated with LY294002 or cisplatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	caspase 3	Rattus norvegicus	18-27
18262389-8	2008	Inhibiting Akt activity with the phosphoinositide-3-kinase inhibitor LY294002 or Akt inhibitor X suppressed HGF-induced phosphorylation of GSK-3beta, increased MAP2 phosphorylation, and blocked the ability of HGF to enhance dendritic length.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	hepatocyte growth factor	Homo sapiens	108-111
18262389-8	2008	Inhibiting Akt activity with the phosphoinositide-3-kinase inhibitor LY294002 or Akt inhibitor X suppressed HGF-induced phosphorylation of GSK-3beta, increased MAP2 phosphorylation, and blocked the ability of HGF to enhance dendritic length.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	glycogen synthase kinase 3 beta	Homo sapiens	139-148
18451215-8	2008	In PTEN-null and LKB1-null endometrial carcinoma cell lines with functional inactivation of TSC2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 were able to inhibit AKT and mTOR signaling and reverse TSC2 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	98-127
18262389-8	2008	Inhibiting Akt activity with the phosphoinositide-3-kinase inhibitor LY294002 or Akt inhibitor X suppressed HGF-induced phosphorylation of GSK-3beta, increased MAP2 phosphorylation, and blocked the ability of HGF to enhance dendritic length.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	microtubule associated protein 2	Homo sapiens	160-164
18262389-8	2008	Inhibiting Akt activity with the phosphoinositide-3-kinase inhibitor LY294002 or Akt inhibitor X suppressed HGF-induced phosphorylation of GSK-3beta, increased MAP2 phosphorylation, and blocked the ability of HGF to enhance dendritic length.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	hepatocyte growth factor	Homo sapiens	209-212
18451140-6	2008	Treatment of FET DNRII cells with a PI3K inhibitor (LY294002) inhibited Akt phosphorylation and reduced survivin expression resulting in increased apoptosis in FET/DNRII cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	72-75
18355352-11	2008	Both extracellular regulated kinase (ERK) inhibitor (PD98059) and protein kinase B (Akt) inhibitor (LY294002) almost completely blocked the inhibitory effect of MIF on apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	AKT serine/threonine kinase 1	Homo sapiens	84-87
18355352-11	2008	Both extracellular regulated kinase (ERK) inhibitor (PD98059) and protein kinase B (Akt) inhibitor (LY294002) almost completely blocked the inhibitory effect of MIF on apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	macrophage migration inhibitory factor	Homo sapiens	161-164
18307528-8	2008	After the addition of TGF-alpha, AG1478 and an inhibitor of phosphatidylinositol 3 kinase/Akt (LY294002), but not PD98059, induced a marked apoptotic response, which was prevented by the caspase inhibitor Z-VAD fmk.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	transforming growth factor alpha	Rattus norvegicus	22-31
18307528-8	2008	After the addition of TGF-alpha, AG1478 and an inhibitor of phosphatidylinositol 3 kinase/Akt (LY294002), but not PD98059, induced a marked apoptotic response, which was prevented by the caspase inhibitor Z-VAD fmk.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Rattus norvegicus	90-93
18473825-6	2008	The BB-induced stimulatory effect on cell proliferation was prevented by either RC-3095 or the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	gastrin releasing peptide	Homo sapiens	4-6
18473825-6	2008	The BB-induced stimulatory effect on cell proliferation was prevented by either RC-3095 or the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	95-124
18023131-9	2008	Notably, we found that LY294002, a specific inhibitor of PI3-kinase, effectively inhibited EGF-induced MAPK activation as well as subsequent oocyte meiotic resumption and this inhibition could not be reversed by adding additional EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	epidermal growth factor	Homo sapiens	91-94
18389481-6	2008	The results obtained by mutating specific tyrosine residues within the CD28 cytoplasmic tail as well as by using LY294002 inhibitory drug evidenced that the recruitment and activation of the phosphatidylinositol 3-kinase/Akt signalling pathway is crucial in mediating CD28-induced HIV transcription through RelA/NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	CD28 molecule	Homo sapiens	268-272
18023131-9	2008	Notably, we found that LY294002, a specific inhibitor of PI3-kinase, effectively inhibited EGF-induced MAPK activation as well as subsequent oocyte meiotic resumption and this inhibition could not be reversed by adding additional EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	epidermal growth factor	Homo sapiens	230-233
18054196-6	2008	Using the phosphatidylinositol 3-kinase inhibitor (PI3K inhibitor, LY 294002), we found that insulin inhibited the expression of AdipoR2 through the PI3K pathway and this inhibition was blocked by addition of rosiglitazone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-76	insulin	Homo sapiens	93-100
18054196-6	2008	Using the phosphatidylinositol 3-kinase inhibitor (PI3K inhibitor, LY 294002), we found that insulin inhibited the expression of AdipoR2 through the PI3K pathway and this inhibition was blocked by addition of rosiglitazone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-76	adiponectin receptor 2	Homo sapiens	129-136
18389481-6	2008	The results obtained by mutating specific tyrosine residues within the CD28 cytoplasmic tail as well as by using LY294002 inhibitory drug evidenced that the recruitment and activation of the phosphatidylinositol 3-kinase/Akt signalling pathway is crucial in mediating CD28-induced HIV transcription through RelA/NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	RELA proto-oncogene, NF-kB subunit	Homo sapiens	307-311
18389481-6	2008	The results obtained by mutating specific tyrosine residues within the CD28 cytoplasmic tail as well as by using LY294002 inhibitory drug evidenced that the recruitment and activation of the phosphatidylinositol 3-kinase/Akt signalling pathway is crucial in mediating CD28-induced HIV transcription through RelA/NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	nuclear factor kappa B subunit 1	Homo sapiens	312-321
18425342-7	2008	The phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 alone induced PARP cleavage and further augmented cisplatin-induced PARP cleavage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	poly(ADP-ribose) polymerase 1	Homo sapiens	70-74
18358474-5	2008	CD9 promoted cell motility was significantly blocked by phosphatidylinositol-3 kinase (PI-3K) inhibitors, wortmannin and LY294002, whereas inhibitors targeting protein kinase C or mitogen-activated protein kinase had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	CD9 antigen	Cricetulus griseus	0-3
18425342-9	2008	Both rapamycin and Ly294002 enhanced cisplatin-induced acti-vation of ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	mitogen-activated protein kinase 3	Homo sapiens	70-76
18425342-7	2008	The phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 alone induced PARP cleavage and further augmented cisplatin-induced PARP cleavage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	poly(ADP-ribose) polymerase 1	Homo sapiens	124-128
18251703-12	2008	Pathway inhibitors, U0126 or LY294002, strongly increased both Bim mRNA and protein, confirming that both kinases regulate Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	BCL2-like 11 (apoptosis facilitator)	Mus musculus	63-66
18251703-12	2008	Pathway inhibitors, U0126 or LY294002, strongly increased both Bim mRNA and protein, confirming that both kinases regulate Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	BCL2-like 11 (apoptosis facilitator)	Mus musculus	123-126
18702304-6	2008	PI3K and MAPK inhibitor, LY294002 and U0126 could inhibit hypoxia-induced HIF-1 and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	vascular endothelial growth factor A	Homo sapiens	84-88
18182045-7	2008	VEGF activated the phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) signal transduction pathway in the spinal cord cultures, and the effect on motoneuron survival was fully reversed by the specific PI3-K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	vascular endothelial growth factor A	Rattus norvegicus	0-4
18182045-7	2008	VEGF activated the phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) signal transduction pathway in the spinal cord cultures, and the effect on motoneuron survival was fully reversed by the specific PI3-K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	AKT serine/threonine kinase 1	Rattus norvegicus	49-52
18182045-7	2008	VEGF activated the phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) signal transduction pathway in the spinal cord cultures, and the effect on motoneuron survival was fully reversed by the specific PI3-K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
18182053-5	2008	Inhibiting Akt activity by a phosphoinositide 3-kinase inhibitor, LY294002, enlarged infarct in postconditioned rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Rattus norvegicus	11-14
18276798-4	2008	Recombinant Akt dose-dependently increased telomerase activity, and telomerase was inhibited at the transcriptional and post-translational levels by LY294002, suggesting that PI-3K/Akt is one of the key signaling proteins involved in telomerase regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	AKT serine/threonine kinase 1	Homo sapiens	12-15
18276798-4	2008	Recombinant Akt dose-dependently increased telomerase activity, and telomerase was inhibited at the transcriptional and post-translational levels by LY294002, suggesting that PI-3K/Akt is one of the key signaling proteins involved in telomerase regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	AKT serine/threonine kinase 1	Homo sapiens	181-184
18483299-3	2008	We report that inhibition of PI3K/Akt, either by the PI3K inhibitor Ly294002 or by expression of PTEN, synergized the ability of the MDM2 antagonist nutlin-3 to induce apoptosis in acute lymphoblastic leukemia (ALL).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	34-37
17940890-5	2008	The effect of 25 ng/ml FGF2 was blocked by 10 microM genistein, a tyrosine kinase inhibitor and by 25 microM LY294002, a PI3 kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	fibroblast growth factor 2	Rattus norvegicus	23-27
17940890-6	2008	The concomitant treatment with 0.3 microM chelerythrine chloride, a protein kinase C inhibitor, and 6.25 microM LY294002 also inhibited the effect of FGF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	fibroblast growth factor 2	Rattus norvegicus	150-154
18423117-0	2008	[Reversal effect of PI-3K/Akt pathway inhibitor LY294002 on multidrug resistance of ovarian cancer cell line A2780/Taxol].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	26-29
18358617-7	2008	Here we showed that PI3K/akt inhibitors 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002) and KY12420 at low concentrations (2 microM or 20 microM) did not influence RGC survival but caused RGC loss at high concentration (200 muM) in retinal explants derived from intact rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Rattus norvegicus	25-28
18182168-3	2008	Here, we reported that LPS-induced up-regulation of VCAM-1 enhanced the adhesion of neutrophils onto HTSMC monolayer, which was inhibited by LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	vascular cell adhesion molecule 1	Homo sapiens	52-58
18182168-5	2008	LPS-stimulated Src, PYK2, EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src (PP1), EGFR (AG1478), PI3-K (LY294002 and wortmannin), and Akt (SH-5), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	15-18
18182168-5	2008	LPS-stimulated Src, PYK2, EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src (PP1), EGFR (AG1478), PI3-K (LY294002 and wortmannin), and Akt (SH-5), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	protein tyrosine kinase 2 beta	Homo sapiens	20-24
18182168-5	2008	LPS-stimulated Src, PYK2, EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src (PP1), EGFR (AG1478), PI3-K (LY294002 and wortmannin), and Akt (SH-5), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Homo sapiens	36-39
18182168-5	2008	LPS-stimulated Src, PYK2, EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src (PP1), EGFR (AG1478), PI3-K (LY294002 and wortmannin), and Akt (SH-5), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-118
18182168-5	2008	LPS-stimulated Src, PYK2, EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src (PP1), EGFR (AG1478), PI3-K (LY294002 and wortmannin), and Akt (SH-5), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	neuropeptide Y receptor Y4	Homo sapiens	120-123
18182168-5	2008	LPS-stimulated Src, PYK2, EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src (PP1), EGFR (AG1478), PI3-K (LY294002 and wortmannin), and Akt (SH-5), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	epidermal growth factor receptor	Homo sapiens	126-130
18182168-5	2008	LPS-stimulated Src, PYK2, EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src (PP1), EGFR (AG1478), PI3-K (LY294002 and wortmannin), and Akt (SH-5), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-118
18358096-0	2008	LY294002 induces p53-dependent apoptosis of SGC7901 gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor protein p53	Homo sapiens	17-20
18358096-0	2008	LY294002 induces p53-dependent apoptosis of SGC7901 gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	sarcoglycan beta	Homo sapiens	44-47
18358096-1	2008	AIM: To study the effects of LY294002, an inhibitor of class I phosphatidylinositol 3-kinase (PI3K), on proliferation and apoptosis of SGC7901 gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	sarcoglycan beta	Homo sapiens	135-138
18358096-7	2008	Expression of p53 and PUMA was induced, and mitochondrial membrane potential collapsed after treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	tumor protein p53	Homo sapiens	14-17
18358096-9	2008	CONCLUSION: Activation of the p53 pathway is involved in LY294002-induced SGC7901 cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	tumor protein p53	Homo sapiens	30-33
18297688-10	2008	Cells pretreated with LY294002 (PI3K inhibitor) almost completely inhibited (88.3% inhibition) HGF-mediated ANXA1 nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	hepatocyte growth factor	Homo sapiens	95-98
18297688-10	2008	Cells pretreated with LY294002 (PI3K inhibitor) almost completely inhibited (88.3% inhibition) HGF-mediated ANXA1 nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	annexin A1	Homo sapiens	108-113
18956651-1	2008	OBJECTIVE: To investigate the telomerase activity and to document biological behaviors of HeLa cells upon treatment with specific PI3K/AKT signaling pathway inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	AKT serine/threonine kinase 1	Homo sapiens	135-138
18956651-8	2008	Western blot showed that LY294002 enabled to decrease P-AKT activity in the presence of same total AKT protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	56-59
18956651-8	2008	Western blot showed that LY294002 enabled to decrease P-AKT activity in the presence of same total AKT protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	99-102
18956651-14	2008	CONCLUSION: LY294002 inhibition of PI3K/AKT signaling pathway leads to alteration of telomerase activity along with changes of the biological behaviors of the HeLa cells suggesting that regulation of telomerase activity may be closely related to PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Homo sapiens	40-43
18956651-14	2008	CONCLUSION: LY294002 inhibition of PI3K/AKT signaling pathway leads to alteration of telomerase activity along with changes of the biological behaviors of the HeLa cells suggesting that regulation of telomerase activity may be closely related to PI3K/AKT signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Homo sapiens	251-254
18397796-5	2008	Inhibitors of phosphatidylinositol-3-OH kinase (PI-3 kinase), LY294002 and wortmannin, decreased TNFalpha-induced MCP-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	tumor necrosis factor	Bos taurus	97-105
18397796-5	2008	Inhibitors of phosphatidylinositol-3-OH kinase (PI-3 kinase), LY294002 and wortmannin, decreased TNFalpha-induced MCP-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	C-C motif chemokine 2	Bos taurus	114-119
20731895-7	2008	RESULTS: The tumor-inhibiting rate of paclitaxel plus LY294002 (92.47%) was significantly higher than the paclitaxel alone (65.59%)(P &lt;0.05).The protein expression of bcl-2 in paclitaxel plus LY294002 group were significantly higher, while bax was significantly lower than that in the other two groups (P &lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	B cell leukemia/lymphoma 2	Mus musculus	170-175
20731895-7	2008	RESULTS: The tumor-inhibiting rate of paclitaxel plus LY294002 (92.47%) was significantly higher than the paclitaxel alone (65.59%)(P &lt;0.05).The protein expression of bcl-2 in paclitaxel plus LY294002 group were significantly higher, while bax was significantly lower than that in the other two groups (P &lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	BCL2-associated X protein	Mus musculus	243-246
18423117-3	2008	This study was to investigate the reversal effect of LY294002, a PI-3K/Akt inhibitor, on paclitaxel-resistance of ovarian carcinoma cell line A2780/Taxol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	71-74
18048804-7	2008	The HO-1 induction was also decreased by phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	heme oxygenase 1	Homo sapiens	4-8
18423117-12	2008	PI-3K/Akt inhibitor, LY294002 has a reversal effect on the paclitaxel-resistance of A2780/Taxol cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	6-9
18048804-7	2008	The HO-1 induction was also decreased by phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	41-70
18258814-8	2008	The glucose-induced TRPC6 expression was significantly attenuated in the presence of wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	transient receptor potential cation channel subfamily C member 6	Homo sapiens	20-25
18256309-7	2008	Autophagy inhibitors LY294002 or 3-methyladenine or wortmannin inhibited the formation of autophagosomes but induced apoptosis after 2-4 h of cisplatin treatment as indicated by caspase-3/7 and -6 activation, nuclear fragmentation, and cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	caspase 3	Homo sapiens	178-196
18245559-10	2008	Pharmacological blockade of PI3-kinase-Akt pathway with LY-294002 inhibited FMD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-65	thymoma viral proto-oncogene 1	Mus musculus	39-42
17971154-9	2008	The expression level of pIgR by TNF-alpha was decreased by LY294002, an inhibitor of phosphatidylinositol-3-kinase (PI3K), at the transcriptional level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	polymeric immunoglobulin receptor	Homo sapiens	24-28
18278798-6	2008	Motor behavior tests and tyrosine hydroxylase immunoreactivity revealed that the inhibitor of the PI3K/Akt pathway (LY294002) blocked the survival effects of both estrogen and IGF-1, while an inhibitor of the MAPK/ERK signaling (PD98059) was ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Rattus norvegicus	103-106
18278798-6	2008	Motor behavior tests and tyrosine hydroxylase immunoreactivity revealed that the inhibitor of the PI3K/Akt pathway (LY294002) blocked the survival effects of both estrogen and IGF-1, while an inhibitor of the MAPK/ERK signaling (PD98059) was ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	insulin-like growth factor 1	Rattus norvegicus	176-181
18278798-6	2008	Motor behavior tests and tyrosine hydroxylase immunoreactivity revealed that the inhibitor of the PI3K/Akt pathway (LY294002) blocked the survival effects of both estrogen and IGF-1, while an inhibitor of the MAPK/ERK signaling (PD98059) was ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	Eph receptor B1	Rattus norvegicus	214-217
18243161-4	2008	In addition, the pharmacological inhibitors of PI3K (wortmannin and LY294002) enhance phosphorylation of NF-kappaB p65 on Ser529 and Ser536 residues, which result in enhanced p65 transactivation activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	RELA proto-oncogene, NF-kB subunit	Homo sapiens	115-118
18243161-4	2008	In addition, the pharmacological inhibitors of PI3K (wortmannin and LY294002) enhance phosphorylation of NF-kappaB p65 on Ser529 and Ser536 residues, which result in enhanced p65 transactivation activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	RELA proto-oncogene, NF-kB subunit	Homo sapiens	175-178
18336469-12	2008	In addition, hypoxia-induced increase of cell-cycle regulatory protein expression and [(3)H]-thymidine incorporation were attenuated by LY294002 (PI3K inhibitor, 10(-6) M), Akt inhibitor (10(-6) M), rapamycin (mTOR inhibitor, 10(-9) M), PD98059 (p44/42 inhibitor, 10(-5) M), and SB203580 (p38 MAPK inhibitor, 10(-6) M).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	mechanistic target of rapamycin kinase	Mus musculus	210-214
18336469-12	2008	In addition, hypoxia-induced increase of cell-cycle regulatory protein expression and [(3)H]-thymidine incorporation were attenuated by LY294002 (PI3K inhibitor, 10(-6) M), Akt inhibitor (10(-6) M), rapamycin (mTOR inhibitor, 10(-9) M), PD98059 (p44/42 inhibitor, 10(-5) M), and SB203580 (p38 MAPK inhibitor, 10(-6) M).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	mitogen-activated protein kinase 14	Mus musculus	289-297
18093681-7	2008	On the other hand, wortmannin and LY294002 markedly increased p-cofilin and p-LIMK1 without influencing on the level of SSH1 protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	cofilin-1	Sus scrofa	64-71
18093681-7	2008	On the other hand, wortmannin and LY294002 markedly increased p-cofilin and p-LIMK1 without influencing on the level of SSH1 protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	LIM domain kinase 1	Sus scrofa	78-83
17971154-9	2008	The expression level of pIgR by TNF-alpha was decreased by LY294002, an inhibitor of phosphatidylinositol-3-kinase (PI3K), at the transcriptional level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	tumor necrosis factor	Homo sapiens	32-41
17971154-9	2008	The expression level of pIgR by TNF-alpha was decreased by LY294002, an inhibitor of phosphatidylinositol-3-kinase (PI3K), at the transcriptional level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	85-114
18385090-9	2008	RESULTS: PI3K inhibitors wortmannin and LY294002 caused dose-dependent cellular and mitochondrial GSH depletion and downregulation of the modulatory subunit of GCL in cultured RPE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	glutamate-cysteine ligase catalytic subunit	Homo sapiens	160-163
18385090-10	2008	Both the basal and the induced Nrf2 activities were inhibited by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
18385090-12	2008	LY294002 also inhibited sulforaphane-induced Nrf2 nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
18005231-6	2008	Inhibition of the PI3K/Akt pathway by LY294002, impeded the short-term effect of H2O2 on nuclear translocation of Nrf2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	23-26
18358890-4	2008	LPS-stimulated translocation of nuclear factor kappa B (NF-kappaB) into the nucleus, which was blocked by inhibitors of amino kinase terminal (AKT, LY294002), extracellular signal regulated kinase 1/2 (ERK 1/2, PD98059), p38 (SB203580), and c-jun NH2-terminal kinase (JNK, SP600125) or terrein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	nuclear factor kappa B subunit 1	Homo sapiens	32-54
18358890-4	2008	LPS-stimulated translocation of nuclear factor kappa B (NF-kappaB) into the nucleus, which was blocked by inhibitors of amino kinase terminal (AKT, LY294002), extracellular signal regulated kinase 1/2 (ERK 1/2, PD98059), p38 (SB203580), and c-jun NH2-terminal kinase (JNK, SP600125) or terrein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	nuclear factor kappa B subunit 1	Homo sapiens	56-65
18005231-6	2008	Inhibition of the PI3K/Akt pathway by LY294002, impeded the short-term effect of H2O2 on nuclear translocation of Nrf2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
18262558-10	2008	PI3K inhibitor (LY294002) inhibited the growth of an esophageal cancer cell line with a PIK3CA mutation (E545K) in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	88-94
18303854-3	2008	The effect of 1 on glucose uptake was completely nullified by pretreatment with LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and RO318220, an inhibitor of protein kinase C (PKC).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	106-131
18191107-4	2008	Phosphatidylinositol 3-kinase inhibitor (PI3K; Ly294002) or Akt inhibitor inhibited the TGF-beta1-induced increase the migration of chondrosarcoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	transforming growth factor beta 1	Homo sapiens	88-97
18756950-13	2008	The number of apoptotic neurons of the 10 micromol/L ketamine group was significantly higher than that pf the control group, the number of apoptotic neurons of the 10 micromol/L ketamine + 10 U/ml EPO group was significantly lower than that of the 10 micromol/L ketamine, and the number of apoptotic neurons of the ketamine + EPO + LY294002 group was (130 +/- 30)%, remarkably lower than that of the ketamine group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	332-340	erythropoietin	Rattus norvegicus	197-200
18756950-15	2008	The relative activity of caspase-3 of the ketamine + EPO + LY294002 group was (220 +/- 34)%, significantly higher than that of the ketamine + EPO (P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	caspase 3	Rattus norvegicus	25-34
18756950-15	2008	The relative activity of caspase-3 of the ketamine + EPO + LY294002 group was (220 +/- 34)%, significantly higher than that of the ketamine + EPO (P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	erythropoietin	Rattus norvegicus	53-56
18206982-10	2008	Secretion of IL-5 from KU-812 basophils co-cultured with epithelial cells was significantly inhibited by LY294002, an inhibitor of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	interleukin 5	Homo sapiens	13-17
18191107-8	2008	The TGF-beta1-mediated increases in IKKalpha/beta phosphorylation and p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	transforming growth factor beta 1	Homo sapiens	4-13
18191107-8	2008	The TGF-beta1-mediated increases in IKKalpha/beta phosphorylation and p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	36-44
18191107-8	2008	The TGF-beta1-mediated increases in IKKalpha/beta phosphorylation and p65 Ser(536) phosphorylation were inhibited by Ly294002 and Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	RELA proto-oncogene, NF-kB subunit	Homo sapiens	70-73
18409050-7	2008	Pretreatment with phosphatidylinositol 3" kinase (Pl3K) inhibitor LY294002 or eNOS inhibitor NG-nitro-arginine methyl ester (LN or L-NAME) inhibited crocetin effect on p-Akt or eNOS, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	170-173
18239058-7	2008	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed IL-1beta-, IFN-gamma-, and TNF-alpha-induced IL-32alpha mRNA expression, although MAPK inhibitors had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	interleukin 1 beta	Homo sapiens	82-90
18239058-7	2008	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed IL-1beta-, IFN-gamma-, and TNF-alpha-induced IL-32alpha mRNA expression, although MAPK inhibitors had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	interferon gamma	Homo sapiens	93-102
18239058-7	2008	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed IL-1beta-, IFN-gamma-, and TNF-alpha-induced IL-32alpha mRNA expression, although MAPK inhibitors had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	tumor necrosis factor	Homo sapiens	109-118
18239058-7	2008	An inhibitor of phosphatidylinositol 3-kinase (LY294002) significantly suppressed IL-1beta-, IFN-gamma-, and TNF-alpha-induced IL-32alpha mRNA expression, although MAPK inhibitors had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	interleukin 32	Homo sapiens	127-137
18239058-9	2008	Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha-induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma-induced activated protein-1 (AP-1) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	interleukin 1 beta	Homo sapiens	38-46
18239058-9	2008	Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha-induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma-induced activated protein-1 (AP-1) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	tumor necrosis factor	Homo sapiens	52-61
18239058-9	2008	Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha-induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma-induced activated protein-1 (AP-1) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	interleukin 1 beta	Homo sapiens	95-103
18239058-9	2008	Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha-induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma-induced activated protein-1 (AP-1) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	tumor necrosis factor	Homo sapiens	106-115
18239058-9	2008	Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha-induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma-induced activated protein-1 (AP-1) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	interferon gamma	Homo sapiens	122-131
18330473-0	2008	Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	8-37
18330473-0	2008	Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	tumor protein p53	Homo sapiens	107-110
18330473-1	2008	We aimed to study the effects of LY294002, an inhibitor of class I phosphatidylinositol 3-kinase (PI3K), on proliferation, apoptosis, and autophagy in gastric cancer cell line SGC7901.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	67-96
18330473-3	2008	We also showed that LY294002 increased the expression of microtubule-associated protein 1 light chain 3 (LC3), and increased monodansylcadaverine (MDC)-labeled vesicles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	105-108
18330473-4	2008	LY294002 activated autophagy by activating p53 and caspase-3, and induced apoptosis by up-regulating p53 and p53-up-regulated modulator of apoptosis (PUMA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor protein p53	Homo sapiens	43-46
18330473-4	2008	LY294002 activated autophagy by activating p53 and caspase-3, and induced apoptosis by up-regulating p53 and p53-up-regulated modulator of apoptosis (PUMA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor protein p53	Homo sapiens	101-104
18330473-4	2008	LY294002 activated autophagy by activating p53 and caspase-3, and induced apoptosis by up-regulating p53 and p53-up-regulated modulator of apoptosis (PUMA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor protein p53	Homo sapiens	101-104
18330473-5	2008	Therefore, LY294002 might induce cytotoxicity in SGC7901 cells through activation of p53 and the downstream point PUMA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	tumor protein p53	Homo sapiens	85-88
18278556-5	2008	Sodium orthovanadate, a general pharmacological phosphatase blocker and LY294002, an inhibitor of PI3-kinase/Akt pathway, were respectively used to inhibit PTP-1B and Akt activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Rattus norvegicus	109-112
18278556-5	2008	Sodium orthovanadate, a general pharmacological phosphatase blocker and LY294002, an inhibitor of PI3-kinase/Akt pathway, were respectively used to inhibit PTP-1B and Akt activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	156-162
18278556-5	2008	Sodium orthovanadate, a general pharmacological phosphatase blocker and LY294002, an inhibitor of PI3-kinase/Akt pathway, were respectively used to inhibit PTP-1B and Akt activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Rattus norvegicus	167-170
18164268-7	2008	Ectopic expression of constitutively active Akt (Myc-Akt(Myr)) rendered MCF-7 cells resistant to activation by TGF-beta and the growth inhibitory effects of 4-OHT, while over-expression of kinase-dead Akt (Myc-Akt(K179M)) or LY294002 treatment of Tam-R cells enhanced TGF-beta activation and blocked cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	225-233	AKT serine/threonine kinase 1	Homo sapiens	44-47
18409050-7	2008	Pretreatment with phosphatidylinositol 3" kinase (Pl3K) inhibitor LY294002 or eNOS inhibitor NG-nitro-arginine methyl ester (LN or L-NAME) inhibited crocetin effect on p-Akt or eNOS, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	nitric oxide synthase 3	Homo sapiens	177-181
18164268-7	2008	Ectopic expression of constitutively active Akt (Myc-Akt(Myr)) rendered MCF-7 cells resistant to activation by TGF-beta and the growth inhibitory effects of 4-OHT, while over-expression of kinase-dead Akt (Myc-Akt(K179M)) or LY294002 treatment of Tam-R cells enhanced TGF-beta activation and blocked cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	225-233	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	49-52
17721914-9	2008	The levels of phosphorylated Akt (Ser473) were elevated in U937/FN cells and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 suppressed XIAP expression and restored the chemosensitivity to daunorubicin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	AKT serine/threonine kinase 1	Homo sapiens	29-32
18174238-7	2008	Both LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), and overexpression of a dominant-negative form of PDK-1 inhibited the JunD-stimulating effect in reporter assays.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	39-68
18174238-7	2008	Both LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), and overexpression of a dominant-negative form of PDK-1 inhibited the JunD-stimulating effect in reporter assays.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-151
18174238-8	2008	LY294002 also prevented the serum-induced recruitment of JunD, but not p65 or p50 to the promoter in ChIP assay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-61
18174238-9	2008	JunD-p65 complexes, identified in vivo by co-immunoprecipitation, were decreased by LY294002 and by small interfering RNA inhibition of PDK-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
18174238-9	2008	JunD-p65 complexes, identified in vivo by co-immunoprecipitation, were decreased by LY294002 and by small interfering RNA inhibition of PDK-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	RELA proto-oncogene, NF-kB subunit	Homo sapiens	5-8
18256541-6	2008	Inhibition of PI3K with either LY294002 and wortmannin was sufficient to cause upregulation of ERK activity as measured by immunoblotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	mitogen-activated protein kinase 1	Homo sapiens	95-98
17721914-9	2008	The levels of phosphorylated Akt (Ser473) were elevated in U937/FN cells and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 suppressed XIAP expression and restored the chemosensitivity to daunorubicin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	fibronectin 1	Homo sapiens	64-66
17721914-9	2008	The levels of phosphorylated Akt (Ser473) were elevated in U937/FN cells and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 suppressed XIAP expression and restored the chemosensitivity to daunorubicin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	X-linked inhibitor of apoptosis	Homo sapiens	148-152
18292945-10	2008	Inhibition of the PI3-K cascade with LY294002 was also more effective in the presence of laminin-1 and AG73T.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	peptidase inhibitor 3	Homo sapiens	18-21
18292946-8	2008	A specific inhibitor for the phosphatidylinositol 3-kinase/AKT pathway, LY294002, inhibited cell growth and AKT and pRB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	59-62
18292946-8	2008	A specific inhibitor for the phosphatidylinositol 3-kinase/AKT pathway, LY294002, inhibited cell growth and AKT and pRB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	108-111
18292946-8	2008	A specific inhibitor for the phosphatidylinositol 3-kinase/AKT pathway, LY294002, inhibited cell growth and AKT and pRB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	RB transcriptional corepressor 1	Homo sapiens	116-119
18060476-6	2008	Both LY294002 and rapamycin severely suppressed lipid accumulation, as well as the expression of adipogenic markers, including PPAR gamma 2 and C/EBP alpha, two master adipogenic transcription factors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	CCAAT enhancer binding protein alpha	Homo sapiens	144-155
17786963-5	2008	The HNP-induced IL-8 production was blocked by the Src tyrosine kinase inhibitor PP2, MEK1/2 inhibitor U0126, and the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002, but not by the JNK inhibitor SP600125 in both cell types.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	kallikrein related peptidase 8	Homo sapiens	4-7
17786963-5	2008	The HNP-induced IL-8 production was blocked by the Src tyrosine kinase inhibitor PP2, MEK1/2 inhibitor U0126, and the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002, but not by the JNK inhibitor SP600125 in both cell types.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	C-X-C motif chemokine ligand 8	Homo sapiens	16-20
18178094-6	2008	LY294002 blocked the increase in phospho-AKT evoked by SC51089 and abolished the associated protective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	41-44
17996985-5	2008	Wortmannin (10 nM) and LY 294002 (10 microM) (inhibitors of phosphatidylinositol-3-kinase, PI3-K) reversed the inhibitory effect of memantine on the staurosporine-induced LDH release, suggesting that the PI3-K/Akt prosurvival pathway is a possible target for antiapoptotic action of memantine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-32	AKT serine/threonine kinase 1	Homo sapiens	210-213
18488333-4	2008	RESULTS: LY294002 and SC203580 signficantly inhibited PC-3 cell proliferation (P &lt; 0.05), COX-2 expression and PGE2 production after EGF stimulation (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	93-98
18096819-10	2008	In contrast, the titin switch could be stalled by the phosphatidylinositol 3-kinase inhibitor LY294002, which decreased the proportion of N2B mRNA transcripts within hours and suppressed a rapid T3-induced increase in Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	titin	Homo sapiens	17-22
18096819-10	2008	In contrast, the titin switch could be stalled by the phosphatidylinositol 3-kinase inhibitor LY294002, which decreased the proportion of N2B mRNA transcripts within hours and suppressed a rapid T3-induced increase in Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	AKT serine/threonine kinase 1	Homo sapiens	218-221
18488333-4	2008	RESULTS: LY294002 and SC203580 signficantly inhibited PC-3 cell proliferation (P &lt; 0.05), COX-2 expression and PGE2 production after EGF stimulation (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	epidermal growth factor	Homo sapiens	136-139
18201823-7	2008	Akt was phosphorylated 60 min after caffeine administration in a dose dependent manner; PI3K inhibitors, wortmannin and LY294002 canceled this cytoprotective effect of caffeine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	0-3
18021765-6	2008	While LY294002, a non-selective phosphotidylinositol 3-kinase (PI3K) inhibitor, was able to reduce brazilin-induced phosphorylation of Akt and the subsequent induction of HO-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	AKT serine/threonine kinase 1	Homo sapiens	135-138
18085586-10	2008	We found that the PI3K inhibitors wortmannin and LY294002 significantly reduced the estrogen-mediated GABA(B) receptor desensitization in POMC arcuate neurons, suggesting that PI3K signaling is a critical downstream mediator of the estrogen-mediated rapid effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	pro-opiomelanocortin	Cavia porcellus	138-142
17989064-5	2008	Glucose-induced Pax4 expression was abolished by the inhibitors LY294002, PD98050 or H89.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	paired box 4	Homo sapiens	16-20
18206295-5	2008	Akt/PKB activation by GnRH and IGF-1 was completely eliminated in the presence of the PI3-kinase inhibitor, LY 294002, but not in the presence of an Akt/PKB inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-117	thymoma viral proto-oncogene 1	Mus musculus	4-7
18206295-5	2008	Akt/PKB activation by GnRH and IGF-1 was completely eliminated in the presence of the PI3-kinase inhibitor, LY 294002, but not in the presence of an Akt/PKB inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-117	gonadotropin releasing hormone 1	Mus musculus	22-26
18206295-5	2008	Akt/PKB activation by GnRH and IGF-1 was completely eliminated in the presence of the PI3-kinase inhibitor, LY 294002, but not in the presence of an Akt/PKB inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-117	insulin-like growth factor 1	Mus musculus	31-36
18206295-7	2008	Phosphorylation of ERK was significantly increased in the presence of LY 294002 alone, and was further increased when GnRH was used in combination with LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-79	mitogen-activated protein kinase 1	Mus musculus	19-22
18206295-7	2008	Phosphorylation of ERK was significantly increased in the presence of LY 294002 alone, and was further increased when GnRH was used in combination with LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-79	gonadotropin releasing hormone 1	Mus musculus	118-122
18206295-7	2008	Phosphorylation of ERK was significantly increased in the presence of LY 294002 alone, and was further increased when GnRH was used in combination with LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-161	mitogen-activated protein kinase 1	Mus musculus	19-22
18206295-8	2008	In experiments using a luciferase reporter construct containing the serum response element (SRE), a known target of the ERK pathway, LY 294002 but not the Akt/PKB inhibitor increased SRE-luciferase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-142	mitogen-activated protein kinase 1	Mus musculus	120-123
18206295-9	2008	GnRH-induced SRE-luciferase activity was significantly increased by LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-77	gonadotropin releasing hormone 1	Mus musculus	0-4
18206295-11	2008	GnRH-induced gonadotropin promoter activities were not modulated in the presence of an Akt/PKB inhibitor, but treatment with LY 294002 or Wortmannin resulted in a significant increase in alpha- and FSHbeta-subunit promoter activation, both with and without GnRH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-134	follicle stimulating hormone beta	Mus musculus	198-205
18206295-11	2008	GnRH-induced gonadotropin promoter activities were not modulated in the presence of an Akt/PKB inhibitor, but treatment with LY 294002 or Wortmannin resulted in a significant increase in alpha- and FSHbeta-subunit promoter activation, both with and without GnRH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-134	gonadotropin releasing hormone 1	Mus musculus	257-261
18021765-6	2008	While LY294002, a non-selective phosphotidylinositol 3-kinase (PI3K) inhibitor, was able to reduce brazilin-induced phosphorylation of Akt and the subsequent induction of HO-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	heme oxygenase 1	Homo sapiens	171-175
18077599-7	2008	In contrast, inhibiting Akt activation by expressing dominant negative (inactive) Akt or using 20 microM LY294002 exacerbated decreases in electron transport rate, state 3 respiration, ATP production, DeltaPsi(m), and activities of complex I, complex III, and F(0)F(1)-ATPase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	24-27
17971516-10	2008	LY-294002 completely abolished TNF-alpha-induced stimulation of PS as well as phosphorylation of Akt and its downstream targets GSK-3, p70(S6K), and 4E-BP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	tumor necrosis factor	Homo sapiens	31-40
17971516-10	2008	LY-294002 completely abolished TNF-alpha-induced stimulation of PS as well as phosphorylation of Akt and its downstream targets GSK-3, p70(S6K), and 4E-BP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	AKT serine/threonine kinase 1	Homo sapiens	97-100
17971516-10	2008	LY-294002 completely abolished TNF-alpha-induced stimulation of PS as well as phosphorylation of Akt and its downstream targets GSK-3, p70(S6K), and 4E-BP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	ubiquitin associated and SH3 domain containing B	Homo sapiens	135-138
17971516-10	2008	LY-294002 completely abolished TNF-alpha-induced stimulation of PS as well as phosphorylation of Akt and its downstream targets GSK-3, p70(S6K), and 4E-BP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	ribosomal protein S6 kinase B1	Homo sapiens	139-142
17971516-10	2008	LY-294002 completely abolished TNF-alpha-induced stimulation of PS as well as phosphorylation of Akt and its downstream targets GSK-3, p70(S6K), and 4E-BP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	149-155
18077599-7	2008	In contrast, inhibiting Akt activation by expressing dominant negative (inactive) Akt or using 20 microM LY294002 exacerbated decreases in electron transport rate, state 3 respiration, ATP production, DeltaPsi(m), and activities of complex I, complex III, and F(0)F(1)-ATPase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	ATP synthase F1 subunit epsilon	Homo sapiens	232-275
18071906-6	2008	We found that XIAP and Akt were functionally linked in uterine cancer cells, as downregulation of XIAP with RNAi decreased P-Akt levels, and inhibition of PI3-K/Akt activity using LY294002 decreased XIAP content.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	X-linked inhibitor of apoptosis	Homo sapiens	14-18
18071906-6	2008	We found that XIAP and Akt were functionally linked in uterine cancer cells, as downregulation of XIAP with RNAi decreased P-Akt levels, and inhibition of PI3-K/Akt activity using LY294002 decreased XIAP content.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	AKT serine/threonine kinase 1	Homo sapiens	23-26
17961125-2	2008	PIF induced transient phosphorylation of Akt at Ser(473) within 30 min, which was attenuated by the PI3K (phosphoinositide 3-kinase) inhibitor LY294002 and the tyrosine kinase inhibitor genistein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	dermcidin	Homo sapiens	0-3
17961125-2	2008	PIF induced transient phosphorylation of Akt at Ser(473) within 30 min, which was attenuated by the PI3K (phosphoinositide 3-kinase) inhibitor LY294002 and the tyrosine kinase inhibitor genistein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	AKT serine/threonine kinase 1	Homo sapiens	41-44
17719815-8	2008	The IGFBP-3-promoted apoptosis in the presence of IFN-gamma could also be abrogated by blockade of the mTOR pathway with its pharmacological inhibitors, LY294002 or rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	insulin like growth factor binding protein 3	Homo sapiens	4-11
17992191-11	2008	The prosurvival effect of adenoviral vector carrying the human NGF gene was inhibited in vitro by K252a, LY294002 (a pan-phosphatidyl inositol 3-kinase - PI3K - inhibitor), an Akt small interfering RNA, and adenoviruses carrying a dominant negative mutant form of Akt (Ad.DN.Akt) or an Akt-resistant Foxo-3a (Ad.AAA-Foxo-3a).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	nerve growth factor	Homo sapiens	63-66
17992191-11	2008	The prosurvival effect of adenoviral vector carrying the human NGF gene was inhibited in vitro by K252a, LY294002 (a pan-phosphatidyl inositol 3-kinase - PI3K - inhibitor), an Akt small interfering RNA, and adenoviruses carrying a dominant negative mutant form of Akt (Ad.DN.Akt) or an Akt-resistant Foxo-3a (Ad.AAA-Foxo-3a).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	176-179
17992191-11	2008	The prosurvival effect of adenoviral vector carrying the human NGF gene was inhibited in vitro by K252a, LY294002 (a pan-phosphatidyl inositol 3-kinase - PI3K - inhibitor), an Akt small interfering RNA, and adenoviruses carrying a dominant negative mutant form of Akt (Ad.DN.Akt) or an Akt-resistant Foxo-3a (Ad.AAA-Foxo-3a).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	264-267
17992191-11	2008	The prosurvival effect of adenoviral vector carrying the human NGF gene was inhibited in vitro by K252a, LY294002 (a pan-phosphatidyl inositol 3-kinase - PI3K - inhibitor), an Akt small interfering RNA, and adenoviruses carrying a dominant negative mutant form of Akt (Ad.DN.Akt) or an Akt-resistant Foxo-3a (Ad.AAA-Foxo-3a).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	269-278
17992191-11	2008	The prosurvival effect of adenoviral vector carrying the human NGF gene was inhibited in vitro by K252a, LY294002 (a pan-phosphatidyl inositol 3-kinase - PI3K - inhibitor), an Akt small interfering RNA, and adenoviruses carrying a dominant negative mutant form of Akt (Ad.DN.Akt) or an Akt-resistant Foxo-3a (Ad.AAA-Foxo-3a).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	264-267
17992191-11	2008	The prosurvival effect of adenoviral vector carrying the human NGF gene was inhibited in vitro by K252a, LY294002 (a pan-phosphatidyl inositol 3-kinase - PI3K - inhibitor), an Akt small interfering RNA, and adenoviruses carrying a dominant negative mutant form of Akt (Ad.DN.Akt) or an Akt-resistant Foxo-3a (Ad.AAA-Foxo-3a).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	forkhead box O3	Homo sapiens	300-307
17992191-11	2008	The prosurvival effect of adenoviral vector carrying the human NGF gene was inhibited in vitro by K252a, LY294002 (a pan-phosphatidyl inositol 3-kinase - PI3K - inhibitor), an Akt small interfering RNA, and adenoviruses carrying a dominant negative mutant form of Akt (Ad.DN.Akt) or an Akt-resistant Foxo-3a (Ad.AAA-Foxo-3a).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	forkhead box O3	Homo sapiens	316-323
17719815-8	2008	The IGFBP-3-promoted apoptosis in the presence of IFN-gamma could also be abrogated by blockade of the mTOR pathway with its pharmacological inhibitors, LY294002 or rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	interferon gamma	Homo sapiens	50-59
17719815-8	2008	The IGFBP-3-promoted apoptosis in the presence of IFN-gamma could also be abrogated by blockade of the mTOR pathway with its pharmacological inhibitors, LY294002 or rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	mechanistic target of rapamycin kinase	Homo sapiens	103-107
17882162-9	2008	Neuroprotection after postconditioning was inhibited only in the presence of LY294002, which blocks Akt activation, but not U0126 or SB203580, which block ERK and P38 MAP kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Rattus norvegicus	100-103
18252963-10	2008	Specific kinase inhibitors PD98059, SB203580, or LY294002 suppressed the xenoestrogen-induced VEGF response, suggesting activation of MEK, p38 kinase, and phosphatidylinositol-3-kinase pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	vascular endothelial growth factor A	Homo sapiens	94-98
18252963-10	2008	Specific kinase inhibitors PD98059, SB203580, or LY294002 suppressed the xenoestrogen-induced VEGF response, suggesting activation of MEK, p38 kinase, and phosphatidylinositol-3-kinase pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mitogen-activated protein kinase 14	Homo sapiens	139-142
17924084-5	2008	In addition, LPA increased the phosphorylation of AKT-1 with no effects on IRS-1, and LPA-induced glucose uptake was abrogated by pretreatment with the PI 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	thymoma viral proto-oncogene 1	Mus musculus	50-55
17924084-5	2008	In addition, LPA increased the phosphorylation of AKT-1 with no effects on IRS-1, and LPA-induced glucose uptake was abrogated by pretreatment with the PI 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	insulin receptor substrate 1	Mus musculus	75-80
18005341-4	2008	The anti-apoptotic action of SKF83959 was partially abolished by pre-application of the D1 antagonist SCH23390 (30 micromol/L) and the PI 3-kinase (PI 3-K) inhibitor LY294002 but not by the MEK1/2 inhibitor PD98059 (30 micromol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	135-146
17708540-7	2008	Treatment of confluent HGE-17 cells or primary cultures of gastric epithelial cells with the phosphatidylinositol 3-kinase inhibitor LY294002, but not the MEK1 inhibitor, PD98059, significantly inhibits basal and TGFalpha-induced migration following wounding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	transforming growth factor alpha	Homo sapiens	213-221
17849421-7	2008	Using a stable IkappaBalpha mutant LN-18 cell line and pharmacological inhibitors to PI3K/Akt (LY294002) and Akt (Akt2), we provide evidence that Akt and NF-kappaB are activated independently on stimulation with TNF-alpha and both the pathways contribute towards resistance to TNF-alpha mediated cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	nuclear factor kappa B subunit 1	Homo sapiens	154-163
18402055-9	2008	This JNK activation was accumulated by addition of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	mitogen-activated protein kinase 8	Rattus norvegicus	5-8
18314486-7	2008	The phosphorylation of Akt was induced by angiotensin II treatment and inhibited by candesartan, as well as by LY294002, an inhibitor of phosphoinositide 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Homo sapiens	23-26
17560770-11	2008	The insulin anti-apoptotic effect was prevented by Ly29400, a PI3K/Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-58	AKT serine/threonine kinase 1	Homo sapiens	67-70
18402055-12	2008	Ethanol also induced JNK activation and this JNK activation was enhanced by LY294002 similar to HGF treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	mitogen-activated protein kinase 8	Rattus norvegicus	45-48
18160324-4	2008	Whereas inhibition of phosphatidylinositol 3-kinase (PI3K) by LY-294002 blocked fluprostenol-induced changes in total protein content, pre-treatment with rapamycin or with the MEK1/2 inhibitor U0126 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-71	mitogen-activated protein kinase kinase 1	Homo sapiens	176-182
18054391-5	2008	In the present study we have found that inhibition of PI3 kinase by LY294002 in THP-1 cells exposed to LPS attenuated down-regulation of ASK1 activity followed by programmed cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	137-141
17931677-6	2008	Pretreatment of the cells with caspase-9 specific inhibitor z-LEHD-FMK or pan caspase inhibitor Ac-DEVD-CHO prevented LY294002-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	caspase 9	Homo sapiens	31-40
18315925-8	2008	Ly294002 and PD98059 blocked the activation of Akt and ERK1/2 respond to BDNF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	47-50
18315925-8	2008	Ly294002 and PD98059 blocked the activation of Akt and ERK1/2 respond to BDNF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 3	Homo sapiens	55-61
18315925-8	2008	Ly294002 and PD98059 blocked the activation of Akt and ERK1/2 respond to BDNF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	brain derived neurotrophic factor	Homo sapiens	73-77
18315925-10	2008	Furthermore, tube formation of HUVECs toward BDNF was significantly inhibited by 57% and 40% with 20 micromol/L Ly294002 and 20 micromol/L PD98059 treatment, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	brain derived neurotrophic factor	Homo sapiens	45-49
18315925-11	2008	At the same time, Ly294002 and PD98059 reduced the BDNF-induced migration of HUVECs by 74% and 36%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	brain derived neurotrophic factor	Homo sapiens	51-55
18039669-6	2008	We demonstrated that leptin-induced macrophage activation was dependent on phosphatidylinositol 3-kinase (PI3K) activity, since the lipid body formation was inhibited by LY294002 and was absent in the PI3K knock-out mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	leptin	Mus musculus	21-27
18315925-12	2008	While BDNF-induced survival was only blocked by Ly294002 and BDNF-induced proliferation was only inhibited by PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	brain derived neurotrophic factor	Homo sapiens	6-10
17931677-6	2008	Pretreatment of the cells with caspase-9 specific inhibitor z-LEHD-FMK or pan caspase inhibitor Ac-DEVD-CHO prevented LY294002-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	caspase 9	Homo sapiens	31-38
18023419-9	2008	Moreover, Ly 294002, a specific inhibitor of phosphatidylinositol-3-kinase (PI3K)/Akt significantly attenuated the VEGF synthesis stimulated by TGF-beta1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-19	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	45-74
17995453-6	2008	In HEK-293 cells, LY294002 inhibits phosphorylation of Thr596 of TBC1D1, and promotes phosphorylation of AMPK and Ser237 of TBC1D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	TBC1 domain family member 1	Homo sapiens	65-71
18023419-9	2008	Moreover, Ly 294002, a specific inhibitor of phosphatidylinositol-3-kinase (PI3K)/Akt significantly attenuated the VEGF synthesis stimulated by TGF-beta1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-19	AKT serine/threonine kinase 1	Homo sapiens	82-85
18023419-9	2008	Moreover, Ly 294002, a specific inhibitor of phosphatidylinositol-3-kinase (PI3K)/Akt significantly attenuated the VEGF synthesis stimulated by TGF-beta1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-19	vascular endothelial growth factor A	Homo sapiens	115-119
18023419-9	2008	Moreover, Ly 294002, a specific inhibitor of phosphatidylinositol-3-kinase (PI3K)/Akt significantly attenuated the VEGF synthesis stimulated by TGF-beta1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-19	transforming growth factor beta 1	Homo sapiens	144-153
17653089-7	2008	Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, using LY294002, prevented both H2-relaxin-mediated phosphorylation of Akt and GSK-3beta and translocation of beta-catenin/AR into the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	18-47
17653089-7	2008	Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, using LY294002, prevented both H2-relaxin-mediated phosphorylation of Akt and GSK-3beta and translocation of beta-catenin/AR into the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	55-58
17653089-7	2008	Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, using LY294002, prevented both H2-relaxin-mediated phosphorylation of Akt and GSK-3beta and translocation of beta-catenin/AR into the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	138-141
17995453-6	2008	In HEK-293 cells, LY294002 inhibits phosphorylation of Thr596 of TBC1D1, and promotes phosphorylation of AMPK and Ser237 of TBC1D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	105-109
17653089-7	2008	Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, using LY294002, prevented both H2-relaxin-mediated phosphorylation of Akt and GSK-3beta and translocation of beta-catenin/AR into the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	glycogen synthase kinase 3 beta	Homo sapiens	146-155
17995453-6	2008	In HEK-293 cells, LY294002 inhibits phosphorylation of Thr596 of TBC1D1, and promotes phosphorylation of AMPK and Ser237 of TBC1D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	TBC1 domain family member 1	Homo sapiens	124-130
17653089-7	2008	Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, using LY294002, prevented both H2-relaxin-mediated phosphorylation of Akt and GSK-3beta and translocation of beta-catenin/AR into the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	catenin beta 1	Homo sapiens	177-189
17653089-7	2008	Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, using LY294002, prevented both H2-relaxin-mediated phosphorylation of Akt and GSK-3beta and translocation of beta-catenin/AR into the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	androgen receptor	Homo sapiens	190-192
17971449-6	2008	In a long term experiment (-16 h) using primary murine neuron cultures, we interfered in the insulin/phosphoinositide 3-kinase (PI3K) (LY294002 treatment and insulin boost) and mammalian target of rapamycin (mTor) (AICAR and rapamycin treatment) signaling pathways and examined consequent changes in the activities of PP2A, GSK-3beta, and Tau phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	93-126
17986385-4	2008	The presence of the phosphatidylinositol 3-kinase inhibitor LY 294002 selectively reduced the effect on ADAM10 protein levels but not on ADAM10 mRNA levels as determined by RT-PCR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-69	ADAM metallopeptidase domain 10	Homo sapiens	104-110
17993586-8	2008	Laminin competing peptide (YIGSR, 1 microM) and phosphatidylinositol 3-kinase (PI3K) inhibitors (20 microM LY-294002 or 100 nM wortmannin) abrogated the accumulation of smMHC, calponin, and DGC proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-116	myosin heavy chain 11	Homo sapiens	169-174
18032526-8	2008	AGE-induced phosphorylation of FKHRL1 led to a 70% downregulation of MnSOD, an effect partially blocked by a phosphatidylinositol 3-kinase inhibitor (LY-294002) and strongly inhibited by an antioxidant (N-acetylcysteine).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-159	forkhead box O3	Homo sapiens	31-37
18032526-8	2008	AGE-induced phosphorylation of FKHRL1 led to a 70% downregulation of MnSOD, an effect partially blocked by a phosphatidylinositol 3-kinase inhibitor (LY-294002) and strongly inhibited by an antioxidant (N-acetylcysteine).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-159	superoxide dismutase 2	Homo sapiens	69-74
17981805-10	2008	Neurite branching of PC12 cells is known to be inhibited by activation of Akt and promoted by the Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
17901071-7	2008	At the maximal inhibitory dose without cytotoxicity, PD98059 and LY294002 completely inhibited VEGF-induced cell proliferation but only partially attenuated (P &lt; 0.05) FGF2-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	vascular endothelial growth factor A	Mus musculus	95-99
17901071-7	2008	At the maximal inhibitory dose without cytotoxicity, PD98059 and LY294002 completely inhibited VEGF-induced cell proliferation but only partially attenuated (P &lt; 0.05) FGF2-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	fibroblast growth factor 2	Mus musculus	171-175
17901071-8	2008	PD98059 and LY294002 also inhibited (P &lt; 0.05) FGF2- and VEGF-induced phosphorylation of MAPK3/1 and AKT1, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	fibroblast growth factor 2	Mus musculus	50-54
17901071-8	2008	PD98059 and LY294002 also inhibited (P &lt; 0.05) FGF2- and VEGF-induced phosphorylation of MAPK3/1 and AKT1, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	vascular endothelial growth factor A	Mus musculus	60-64
17901071-8	2008	PD98059 and LY294002 also inhibited (P &lt; 0.05) FGF2- and VEGF-induced phosphorylation of MAPK3/1 and AKT1, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	mitogen-activated protein kinase 3	Mus musculus	92-99
17901071-8	2008	PD98059 and LY294002 also inhibited (P &lt; 0.05) FGF2- and VEGF-induced phosphorylation of MAPK3/1 and AKT1, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	thymoma viral proto-oncogene 1	Mus musculus	104-108
18423589-4	2008	Treatment of A549 cells with LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one) and wortmannin, two PI3K inhibitors, inhibited M. bovis BCG-induced IL-10 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-88	interleukin 10	Homo sapiens	158-163
18769058-7	2008	LY294002, a specific inhibitor of PI-3K, significantly inhibited Akt phosphorylation and completely abrogated HAPO-stimulated proliferation of HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	65-68
18769044-6	2008	Treatment with LY294002, a selective PI3K inhibitor, abolished DIDS-induced increases in p-Akt, eNOS, p-eNOS and NO production, and completely abrogated the DIDS-induced anti-apoptotic effect (P&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
18769044-8	2008	In addition, DIDS effectively inhibited STS-induced Bax translocation to mitochondria, which was also reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	BCL2 associated X, apoptosis regulator	Rattus norvegicus	52-55
18453753-13	2008	LY294002 restored IGF-1-induced ERK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin-like growth factor 1	Rattus norvegicus	18-23
18453753-13	2008	LY294002 restored IGF-1-induced ERK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Eph receptor B1	Rattus norvegicus	32-35
18769058-7	2008	LY294002, a specific inhibitor of PI-3K, significantly inhibited Akt phosphorylation and completely abrogated HAPO-stimulated proliferation of HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	proteoglycan 4	Homo sapiens	110-114
18769058-8	2008	rhHAPO enhanced the expression of cyclin D1, where as LY294002 inhibited the up-regulation of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	cyclin D1	Homo sapiens	34-43
18769058-8	2008	rhHAPO enhanced the expression of cyclin D1, where as LY294002 inhibited the up-regulation of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	cyclin D1	Homo sapiens	94-103
18093179-8	2008	In parallel, it was observed that LY294002 and rapamycin almost completely blocked the effects of insulin and IGF-1 on MCT2 protein expression, whereas PD98059 and SB202190 (a p38K inhibitor) had no effect on insulin-induced MCT2 expression and only a slight effect on IGF-1-induced MCT2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	insulin	Homo sapiens	98-105
18093179-8	2008	In parallel, it was observed that LY294002 and rapamycin almost completely blocked the effects of insulin and IGF-1 on MCT2 protein expression, whereas PD98059 and SB202190 (a p38K inhibitor) had no effect on insulin-induced MCT2 expression and only a slight effect on IGF-1-induced MCT2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	insulin like growth factor 1	Homo sapiens	110-115
18093179-6	2008	Phosphorylation of p44- and p42 MAPK was blocked by the MEK inhibitor PD98058, while Akt phosphorylation was abolished by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	interferon induced protein 44	Homo sapiens	19-22
18093179-8	2008	In parallel, it was observed that LY294002 and rapamycin almost completely blocked the effects of insulin and IGF-1 on MCT2 protein expression, whereas PD98059 and SB202190 (a p38K inhibitor) had no effect on insulin-induced MCT2 expression and only a slight effect on IGF-1-induced MCT2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	solute carrier family 16 member 7	Homo sapiens	119-123
18093179-6	2008	Phosphorylation of p44- and p42 MAPK was blocked by the MEK inhibitor PD98058, while Akt phosphorylation was abolished by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Homo sapiens	85-88
17949889-6	2008	However, LY294002 and PD098059 acted using different mechanisms: LY294002 decreased the expression of phosphorylated S6RP, whereas PD098059 increased P21/waf1 antigen expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	150-153
18093179-8	2008	In parallel, it was observed that LY294002 and rapamycin almost completely blocked the effects of insulin and IGF-1 on MCT2 protein expression, whereas PD98059 and SB202190 (a p38K inhibitor) had no effect on insulin-induced MCT2 expression and only a slight effect on IGF-1-induced MCT2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	insulin	Homo sapiens	209-216
17949889-6	2008	However, LY294002 and PD098059 acted using different mechanisms: LY294002 decreased the expression of phosphorylated S6RP, whereas PD098059 increased P21/waf1 antigen expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	154-158
18093179-8	2008	In parallel, it was observed that LY294002 and rapamycin almost completely blocked the effects of insulin and IGF-1 on MCT2 protein expression, whereas PD98059 and SB202190 (a p38K inhibitor) had no effect on insulin-induced MCT2 expression and only a slight effect on IGF-1-induced MCT2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	solute carrier family 16 member 7	Homo sapiens	225-229
17949889-12	2008	CONCLUSION: Our results suggest that KIs modulate proliferation of leukemia cells and that the MEK/ERK inhibitor, PD098059, in combination with either SP600125 or LY294002, could have clinical value.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	mitogen-activated protein kinase kinase 7	Homo sapiens	95-98
17949889-12	2008	CONCLUSION: Our results suggest that KIs modulate proliferation of leukemia cells and that the MEK/ERK inhibitor, PD098059, in combination with either SP600125 or LY294002, could have clinical value.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	mitogen-activated protein kinase 1	Homo sapiens	99-102
18093179-8	2008	In parallel, it was observed that LY294002 and rapamycin almost completely blocked the effects of insulin and IGF-1 on MCT2 protein expression, whereas PD98059 and SB202190 (a p38K inhibitor) had no effect on insulin-induced MCT2 expression and only a slight effect on IGF-1-induced MCT2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	insulin like growth factor 1	Homo sapiens	269-274
18093179-8	2008	In parallel, it was observed that LY294002 and rapamycin almost completely blocked the effects of insulin and IGF-1 on MCT2 protein expression, whereas PD98059 and SB202190 (a p38K inhibitor) had no effect on insulin-induced MCT2 expression and only a slight effect on IGF-1-induced MCT2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	solute carrier family 16 member 7	Homo sapiens	225-229
17579344-7	2008	Under low serum culture conditions, an early (within 1 h) and transient increase in CREB phosphorylation was detected in response to both TRAIL doses and reduced upon pre-treatment with LY294002 or SB253580, demonstrating the PI3-K/Akt- and p38 MAPK-dependency of this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	cAMP responsive element binding protein 1	Homo sapiens	84-88
17920330-7	2008	Phosphorylation and DNA-binding activity of STAT3 were also inhibited by the p38 MAPK inhibitor SB203580 and the phosphatidylinositol 3-kinase inhibitor LY294002, suggesting that multiple signaling pathways involved in STAT activation by hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	signal transducer and activator of transcription 3	Homo sapiens	44-49
18336727-8	2008	The effects of the recombinant allergens on CD13-expression were dose- and time-dependent, were not observed in the absence of extracellular calcium, and were counteracted by preincubation of basophils with the PI3-kinase-targeting drugs staurosporin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	255-263	alanyl aminopeptidase, membrane	Homo sapiens	44-48
18336727-8	2008	The effects of the recombinant allergens on CD13-expression were dose- and time-dependent, were not observed in the absence of extracellular calcium, and were counteracted by preincubation of basophils with the PI3-kinase-targeting drugs staurosporin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	255-263	peptidase inhibitor 3	Homo sapiens	211-214
17457363-6	2008	We then examined the relationship between PRAS40 and Akt by injection of LY294002, a phosphatidylinositol 3-kinase (PI3K) pathway inhibitor, or Akt inhibitor IV, a compound that inhibits Akt activation after SCI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT1 substrate 1	Rattus norvegicus	42-48
17457363-6	2008	We then examined the relationship between PRAS40 and Akt by injection of LY294002, a phosphatidylinositol 3-kinase (PI3K) pathway inhibitor, or Akt inhibitor IV, a compound that inhibits Akt activation after SCI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Rattus norvegicus	53-56
17457363-10	2008	The inhibitor studies showed that phospho-Akt and pPRAS40 were decreased after injection of LY294002 or Akt inhibitor IV.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Rattus norvegicus	42-45
17579344-7	2008	Under low serum culture conditions, an early (within 1 h) and transient increase in CREB phosphorylation was detected in response to both TRAIL doses and reduced upon pre-treatment with LY294002 or SB253580, demonstrating the PI3-K/Akt- and p38 MAPK-dependency of this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	AKT serine/threonine kinase 1	Homo sapiens	232-235
17579344-7	2008	Under low serum culture conditions, an early (within 1 h) and transient increase in CREB phosphorylation was detected in response to both TRAIL doses and reduced upon pre-treatment with LY294002 or SB253580, demonstrating the PI3-K/Akt- and p38 MAPK-dependency of this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	mitogen-activated protein kinase 14	Homo sapiens	241-244
18540849-7	2008	RESULTS: Culture of A375 cells in the presence of fibronectin led to expression of MMP-9 and activation of MMP-2 within 2 h. When cells were treated with ERK inhibitor (PD98059) or PI-3K inhibitor (LY294002) and grown in the presence of fibronectin, MMP-9 expression and MMP-2 activation was inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	198-206	fibronectin 1	Homo sapiens	50-61
18220263-8	2008	The induced eNOS expression was inhibited by LY294002, indicating that the effect of laser on EC could be attributed to the up-regulation of eNOS expression through PI3K pathway at the cellular and molecular levels as a result of the He-Ne laser.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	nitric oxide synthase 3	Homo sapiens	12-16
17497701-10	2008	The activation of ERK1/2 was inhibited by a PI3K inhibitor, LY294002, but U0126, a ERK1/2 inhibitor did not inhibit phosphorylation of Akt and GSK3 beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	mitogen activated protein kinase 3	Rattus norvegicus	18-24
18220263-8	2008	The induced eNOS expression was inhibited by LY294002, indicating that the effect of laser on EC could be attributed to the up-regulation of eNOS expression through PI3K pathway at the cellular and molecular levels as a result of the He-Ne laser.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	nitric oxide synthase 3	Homo sapiens	141-145
17936321-10	2008	LY294002 (an inhibitor of Akt) significantly decreased cell viability and increased the proportion of cells with sub-G1 phase DNA content.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	26-29
18352910-3	2008	Poly IC-induced ISG20 expression was inhibited by LY294002, an inhibitor of PI3K, or by RNA interference against IFN regulatory factor three.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	interferon stimulated exonuclease gene 20	Homo sapiens	16-21
21479382-9	2008	Pretreatment of LY294002, PI3K inhibitor, or PD98059, MAPK inhibitor, partially blocked the heregulin-induced MMP-9 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	matrix metallopeptidase 9	Homo sapiens	110-115
18025837-2	2008	METHODS: The effect of LY294002 on the survival of RF/6A cells stimulated by vascular endothelial growth factor (VEGF) was investigated colorimetrically.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	vascular endothelial growth factor A	Macaca mulatta	77-111
18025837-2	2008	METHODS: The effect of LY294002 on the survival of RF/6A cells stimulated by vascular endothelial growth factor (VEGF) was investigated colorimetrically.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	vascular endothelial growth factor A	Macaca mulatta	113-117
18025837-3	2008	The inhibitory activity of LY294002 on the migration of cells stimulated with VEGF was measured by cell counting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	vascular endothelial growth factor A	Mus musculus	78-82
18025837-5	2008	Beginning on P12, mice received daily intraperitoneal injections of LY294002 or dimethyl sulfoxide and phosphate-buffered saline (control) through P17.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	family with sequence similarity 72, member A	Mus musculus	147-150
18025837-7	2008	RESULTS: LY294002 significantly inhibited VEGF-induced survival and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	vascular endothelial growth factor A	Mus musculus	42-46
17674030-5	2008	Blockade of ERK1/2 with PD 98059 or PI3K/Akt with LY-294002 or Akt inhibitor III during either preconditioning or ischemia periods significantly attenuated the cardioprotection of SP, suggesting that both ERK1/2 and PI3K/Akt triggered and mediated the cardioprotection of SP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	mitogen activated protein kinase 3	Rattus norvegicus	12-18
17674030-5	2008	Blockade of ERK1/2 with PD 98059 or PI3K/Akt with LY-294002 or Akt inhibitor III during either preconditioning or ischemia periods significantly attenuated the cardioprotection of SP, suggesting that both ERK1/2 and PI3K/Akt triggered and mediated the cardioprotection of SP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
18679014-4	2008	The neuroprotective effect of insulin was reversed by LY294002, a phosphatidylinositol 3"-kinase (PI3 kinase) inhibitor, whereas the mitogen-activated protein kinase (MAPK) inhibitor PD98059, an upstream blocker of MAPK had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	insulin	Homo sapiens	30-37
18679014-4	2008	The neuroprotective effect of insulin was reversed by LY294002, a phosphatidylinositol 3"-kinase (PI3 kinase) inhibitor, whereas the mitogen-activated protein kinase (MAPK) inhibitor PD98059, an upstream blocker of MAPK had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	peptidase inhibitor 3	Homo sapiens	98-101
18488712-7	2008	Pretreatment of NUGC-3 cells with PI3K inhibitors, LY 294002, decreased HGF-induced BAD phosphorylation on Ser136 whereas an MEK inhibitor, PD 98059, decreased BAD phosphorylation on Ser112.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-60	hepatocyte growth factor	Homo sapiens	72-75
18289643-11	2008	The involvement of the PI3 kinase/Akt pathway in neutrophil superoxide production was revealed by using LY294002 in isolated neutrophils/platelets experiments, as well as during whole blood aggregation-mediated neutrophil-platelet conjugation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	AKT serine/threonine kinase 1	Homo sapiens	34-37
18182859-10	2007	The phosphorylation of Raf and Akt proteins induced by 0.05 Gy of ionizing radiation was abolished by pre-treatment with an EGFR inhibitor, AG1478, or a PI3k inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	zinc fingers and homeoboxes 2	Homo sapiens	23-26
18158334-5	2007	LY294002 potentiates caffeine"s ability to uncouple histone mRNA stabilization from replication only in cells containing functional DNA-activated protein kinase (DNA-PK), which indicates that DNA-PK is the target of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	132-160
18182859-10	2007	The phosphorylation of Raf and Akt proteins induced by 0.05 Gy of ionizing radiation was abolished by pre-treatment with an EGFR inhibitor, AG1478, or a PI3k inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Homo sapiens	31-34
18158334-5	2007	LY294002 potentiates caffeine"s ability to uncouple histone mRNA stabilization from replication only in cells containing functional DNA-activated protein kinase (DNA-PK), which indicates that DNA-PK is the target of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	162-168
18158334-5	2007	LY294002 potentiates caffeine"s ability to uncouple histone mRNA stabilization from replication only in cells containing functional DNA-activated protein kinase (DNA-PK), which indicates that DNA-PK is the target of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	192-198
18158334-5	2007	LY294002 potentiates caffeine"s ability to uncouple histone mRNA stabilization from replication only in cells containing functional DNA-activated protein kinase (DNA-PK), which indicates that DNA-PK is the target of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	216-224	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	192-198
17904546-3	2007	This was inhibited by antibodies to intercellular adhesion molecule-1 (ICAM-1, 10 microg/ml), and by inhibitors of PI3-kinase (LY294002, 10 microM) and MAPK (mitogen-activated protein kinase) p38 (SB203580, 10 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	mitogen-activated protein kinase 14	Homo sapiens	192-195
17919066-9	2007	Moreover, U0126 and LY294002, which are pharmacologic inhibitors of extracellular signal-regulated kinase1/2 and phosphoinositide 3-kinase, respectively, attenuated HO-1 expression as well as Nrf2-ARE binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	heme oxygenase 1	Rattus norvegicus	165-169
18091994-6	2007	We showed that H(2)O(2) induces rCMECs apoptosis mainly through the PI3K/ERK pathway, since a PI3K inhibitor (LY294002) blocked ERK activation caused by H(2)O(2 )and a specific inhibitor of MEK (U0126) protected cells from apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	Eph receptor B1	Rattus norvegicus	73-76
18091994-6	2007	We showed that H(2)O(2) induces rCMECs apoptosis mainly through the PI3K/ERK pathway, since a PI3K inhibitor (LY294002) blocked ERK activation caused by H(2)O(2 )and a specific inhibitor of MEK (U0126) protected cells from apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	Eph receptor B1	Rattus norvegicus	128-131
17950696-4	2007	Furthermore, we showed that migration toward SDF-1 was reduced by inactivation of either serine/threonine kinase Akt or extracellular signal regulated kinase Erk, which was confirmed by selective pathway inhibitor LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	AKT serine/threonine kinase 1	Homo sapiens	113-116
17950696-4	2007	Furthermore, we showed that migration toward SDF-1 was reduced by inactivation of either serine/threonine kinase Akt or extracellular signal regulated kinase Erk, which was confirmed by selective pathway inhibitor LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	mitogen-activated protein kinase 1	Homo sapiens	158-161
17952604-4	2007	To elucidate a possible mechanism by which EPO exerts its neuroprotective effect, we investigated the phosphoinositide3-kinase pathway using LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	erythropoietin	Rattus norvegicus	43-46
18374201-12	2008	LY294002 and rapamycin blocked Gas6-induced activation of the Akt/mTOR pathway and mesangial hypertrophy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	growth arrest specific 6	Rattus norvegicus	31-35
18374201-12	2008	LY294002 and rapamycin blocked Gas6-induced activation of the Akt/mTOR pathway and mesangial hypertrophy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	62-65
18374201-12	2008	LY294002 and rapamycin blocked Gas6-induced activation of the Akt/mTOR pathway and mesangial hypertrophy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	66-70
17950246-3	2007	In C2C12 myocytes, insulin-induced upregulation of musclin mRNA was significantly decreased by treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, and was abolished in C2C12 myocytes stably expressing a constitutively active Foxo1 (Foxo1-3A), suggesting the involvement of Foxo1 in the regulation of musclin mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	osteocrin	Mus musculus	51-58
17950246-3	2007	In C2C12 myocytes, insulin-induced upregulation of musclin mRNA was significantly decreased by treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, and was abolished in C2C12 myocytes stably expressing a constitutively active Foxo1 (Foxo1-3A), suggesting the involvement of Foxo1 in the regulation of musclin mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	forkhead box O1	Mus musculus	244-249
17950246-3	2007	In C2C12 myocytes, insulin-induced upregulation of musclin mRNA was significantly decreased by treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, and was abolished in C2C12 myocytes stably expressing a constitutively active Foxo1 (Foxo1-3A), suggesting the involvement of Foxo1 in the regulation of musclin mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	forkhead box O1	Mus musculus	251-259
17950246-3	2007	In C2C12 myocytes, insulin-induced upregulation of musclin mRNA was significantly decreased by treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, and was abolished in C2C12 myocytes stably expressing a constitutively active Foxo1 (Foxo1-3A), suggesting the involvement of Foxo1 in the regulation of musclin mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	forkhead box O1	Mus musculus	251-256
17950246-3	2007	In C2C12 myocytes, insulin-induced upregulation of musclin mRNA was significantly decreased by treatment of phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, and was abolished in C2C12 myocytes stably expressing a constitutively active Foxo1 (Foxo1-3A), suggesting the involvement of Foxo1 in the regulation of musclin mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	osteocrin	Mus musculus	319-326
17950696-4	2007	Furthermore, we showed that migration toward SDF-1 was reduced by inactivation of either serine/threonine kinase Akt or extracellular signal regulated kinase Erk, which was confirmed by selective pathway inhibitor LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	C-X-C motif chemokine ligand 12	Homo sapiens	45-50
17980966-6	2007	This effect could be blocked by the phosphatidylinositol 3-kinase (PI3K)/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	thymoma viral proto-oncogene 1	Mus musculus	73-76
17600315-9	2007	The fibronectin-inducing effects of nicotine were associated with activation of extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3-K)/mammalian target of rapamycin (mTOR) signaling pathways, and were abrogated by inhibitors of ERK (PD98059), PI3-K (LY294002), and mTOR (rapamycin), but not by inhibitors of protein kinase (PK)C (calphostin C) and PKA (H89).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	fibronectin 1	Homo sapiens	4-15
17600315-9	2007	The fibronectin-inducing effects of nicotine were associated with activation of extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3-K)/mammalian target of rapamycin (mTOR) signaling pathways, and were abrogated by inhibitors of ERK (PD98059), PI3-K (LY294002), and mTOR (rapamycin), but not by inhibitors of protein kinase (PK)C (calphostin C) and PKA (H89).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	mechanistic target of rapamycin kinase	Homo sapiens	193-197
17952604-5	2007	The neuroprotection of EPO was prevented by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	erythropoietin	Rattus norvegicus	23-26
17952604-8	2007	Decreased caspase-3-like activity by administration of ketamine with EPO was restored by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	caspase-3-like	Rattus norvegicus	10-24
17952604-8	2007	Decreased caspase-3-like activity by administration of ketamine with EPO was restored by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	erythropoietin	Rattus norvegicus	69-72
17919066-9	2007	Moreover, U0126 and LY294002, which are pharmacologic inhibitors of extracellular signal-regulated kinase1/2 and phosphoinositide 3-kinase, respectively, attenuated HO-1 expression as well as Nrf2-ARE binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	192-196
17900864-3	2007	The broad spectrum PI3K isoform inhibitor Ly294002 inhibits CXCL12-stimulated migration of freshly isolated T lymphocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	C-X-C motif chemokine ligand 12	Homo sapiens	60-66
18020951-5	2007	In UC-enriched cells, inhibition of phosphatidylinositol 3-kinase (PI(3)K; using wortmannin or LY294002) attenuated the increase in PON2 mRNA expression by 50%, compared to untreated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	36-65
18020951-5	2007	In UC-enriched cells, inhibition of phosphatidylinositol 3-kinase (PI(3)K; using wortmannin or LY294002) attenuated the increase in PON2 mRNA expression by 50%, compared to untreated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	paraoxonase 2	Homo sapiens	132-136
17660507-9	2007	Thus, these altered signaling pathways converged effectively to prolong survival of TRbeta(PV/PV) mice treated with LY.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-118	apoptosis antagonizing transcription factor	Mus musculus	84-90
18058572-8	2007	Molecular therapeutic small molecules specific to Raf, PI3K, and mTOR include sorafenib, LY-294002, and temsirolimus, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-98	zinc fingers and homeoboxes 2	Homo sapiens	50-53
17855501-11	2007	These studies demonstrated that the PI-3K inhibitors, wortmannin and LY294002, antagonize the ability of CSF-1 to inhibit DC differentiation and to promote caspase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	colony stimulating factor 1	Homo sapiens	105-110
17497700-5	2007	Three different inhibitors, LY294002 for phosphatidylinositol-3-kinase (PI3K), C3 exotransferase for Rho and Y27632 for Rho kinase, suppressed the bFGF-stimulated fibroblast-collagen matrix contraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	fibroblast growth factor 2	Homo sapiens	147-151
17855501-11	2007	These studies demonstrated that the PI-3K inhibitors, wortmannin and LY294002, antagonize the ability of CSF-1 to inhibit DC differentiation and to promote caspase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	caspase 8	Homo sapiens	156-163
17634901-8	2007	Chemical inhibition of PI3K-Akt by LY294002/wortmannin did not affect EGF-mediated NF-kappaB p65 nuclear translocation; and NF-kappaB inhibition by Bay 11-7082 did not suppress Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	28-31
18057776-7	2007	LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and p70S6K phosphorylation, whereas rapamycin, a specific inhibitor of mTOR, suppressed only p70S6K phosphorylation induced by pravastatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	34-63
18057776-7	2007	LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and p70S6K phosphorylation, whereas rapamycin, a specific inhibitor of mTOR, suppressed only p70S6K phosphorylation induced by pravastatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
18057776-7	2007	LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and p70S6K phosphorylation, whereas rapamycin, a specific inhibitor of mTOR, suppressed only p70S6K phosphorylation induced by pravastatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribosomal protein S6 kinase B1	Rattus norvegicus	93-99
18057776-7	2007	LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and p70S6K phosphorylation, whereas rapamycin, a specific inhibitor of mTOR, suppressed only p70S6K phosphorylation induced by pravastatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribosomal protein S6 kinase B1	Rattus norvegicus	182-188
17616812-6	2007	Pretreatment of U87MG cells with the PI3K inhibitor LY294002 could prevent Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	75-78
17804676-5	2007	The action of AGF on glucose production was inhibited by pretreatment of the cells with LY294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one], a phosphoinositide 3-kinase (PI3K) inhibitor, and Akt (protein kinase B) inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Rattus norvegicus	199-202
18043744-11	2007	Furthermore, we tested the pharmacological inhibition of the PTEN downstream effectors using LY294002 on Pten-deficient prostate hyperplasia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	phosphatase and tensin homolog	Mus musculus	105-109
18043744-12	2007	Our data revealed that, indeed, the prostate hyperplasia resulting from the induced Pten loss was significantly suppressed by LY294002 (p = 0.007).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	phosphatase and tensin homolog	Mus musculus	84-88
17638919-4	2007	Transient transfection of Id-1 into HEK293 cells confirmed activation of PI3K/Akt/NFkappaB signaling and the effects were counteracted by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	inhibitor of DNA binding 1, HLH protein	Homo sapiens	26-30
17982039-4	2007	Induced gene expression and HBD-2 promoter activity were attenuated by LY294002, p110alpha small-interfering RNA (siRNA), as well as by an overexpression of constitutively active GSK3beta(S9A) or wild-type phosphatase and tensin homolog.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	defensin beta 4A	Homo sapiens	28-33
17694254-6	2007	LY294002 and UO126, inhibitors of PI3K-Akt and p44/42 phosphorylation respectively, abolished the protective effects of apelin-13 in vitro.Western blot analysis provided further evidence for the involvement of PI3K-Akt and p44/42 in the cardioprotective actions of apelin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	39-42
17694254-6	2007	LY294002 and UO126, inhibitors of PI3K-Akt and p44/42 phosphorylation respectively, abolished the protective effects of apelin-13 in vitro.Western blot analysis provided further evidence for the involvement of PI3K-Akt and p44/42 in the cardioprotective actions of apelin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen activated protein kinase 3	Rattus norvegicus	47-50
17694254-6	2007	LY294002 and UO126, inhibitors of PI3K-Akt and p44/42 phosphorylation respectively, abolished the protective effects of apelin-13 in vitro.Western blot analysis provided further evidence for the involvement of PI3K-Akt and p44/42 in the cardioprotective actions of apelin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	215-218
17694254-6	2007	LY294002 and UO126, inhibitors of PI3K-Akt and p44/42 phosphorylation respectively, abolished the protective effects of apelin-13 in vitro.Western blot analysis provided further evidence for the involvement of PI3K-Akt and p44/42 in the cardioprotective actions of apelin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen activated protein kinase 3	Rattus norvegicus	223-226
17638919-7	2007	In addition, inhibition of PI3K or NFkappaB signaling using the PI3K inhibitor LY294002 or the NFkappaB inhibitor Bay11-7082 increased the sensitivity of Id-1-over-expressing esophageal cancer cells to TNF-alpha-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	inhibitor of DNA binding 1, HLH protein	Homo sapiens	154-158
17638919-4	2007	Transient transfection of Id-1 into HEK293 cells confirmed activation of PI3K/Akt/NFkappaB signaling and the effects were counteracted by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	AKT serine/threonine kinase 1	Homo sapiens	78-81
17638919-4	2007	Transient transfection of Id-1 into HEK293 cells confirmed activation of PI3K/Akt/NFkappaB signaling and the effects were counteracted by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	nuclear factor kappa B subunit 1	Homo sapiens	82-90
17638919-7	2007	In addition, inhibition of PI3K or NFkappaB signaling using the PI3K inhibitor LY294002 or the NFkappaB inhibitor Bay11-7082 increased the sensitivity of Id-1-over-expressing esophageal cancer cells to TNF-alpha-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	nuclear factor kappa B subunit 1	Homo sapiens	35-43
18173916-8	2007	Interestingly, the apoptosis induced by anti-Fas antibody along with LY294002 was clearly inhibited by the addition of 10 ng/ml EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	epidermal growth factor	Homo sapiens	128-131
17974973-8	2007	PP2, a Src inhibitor, and LY294002, a phosphatidylinositol 3-kinase inhibitor, also suppressed HGF-induced invasion in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	hepatocyte growth factor	Homo sapiens	95-98
17889269-10	2007	Phospho-PKB was detectable independent of irradiation or dexamethasone pretreatment, but was undetectable upon incubations with LY294002 or Wortmannin, whereas phospho-PKC rested detectable.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	thymoma viral proto-oncogene 2	Mus musculus	8-11
17604323-10	2007	Dominant-negative (DN) AKT and LY294002 (PI3K inhibitor) or U0126 (MEK-1/2 inhibitor) blocked chenodeoxycholic acid (CD) and deoxycholic acid (DC) mediated COX-2 induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	156-161
17912441-3	2007	We found that two PI 3-K inhibitors, wortmannin and LY294002, markedly suppressed the phosphorylation of Akt in OSCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	105-108
18025271-10	2007	Anti-HER2 antibody in combination with LY294002, rapamycin, or SP600125 induced greater cyclin G2 expression than either agent alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	cyclin G2	Homo sapiens	88-97
17715378-6	2007	Isochaihulactone-induced increases in EGR-1 and NAG-1 expression were reduced by the mitogen-activated protein kinase kinase 1/2 inhibitor 2"-amino-3"-methoxyflavone (PD98059), and this effect was not blocked by the phosphatidylinositol 3-kinase/protein kinase B pathway inhibitor 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	346-354	early growth response 1	Homo sapiens	38-43
17715378-6	2007	Isochaihulactone-induced increases in EGR-1 and NAG-1 expression were reduced by the mitogen-activated protein kinase kinase 1/2 inhibitor 2"-amino-3"-methoxyflavone (PD98059), and this effect was not blocked by the phosphatidylinositol 3-kinase/protein kinase B pathway inhibitor 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	346-354	growth differentiation factor 15	Homo sapiens	48-53
17407140-10	2007	PI3K inhibitor LY294002 upregulated p27(Kip1) at post-translational level and downregulate Skp2 at mRNA level, which could mimic the effects of integrin beta1 overexpression on p27(Kip1) and Skp2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	dynactin subunit 6	Homo sapiens	36-39
17562163-6	2007	The ERK activation was inhibited by U0126, a specific inhibitor of MEK, but not by LY294002, a specific inhibitor of PI3K, whereas the Akt activation was blocked by LY294002, but not by U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	thymoma viral proto-oncogene 1	Mus musculus	135-138
17940706-10	2007	Inhibition of Akt activation with LY294002 abolished, and inhibition of JNK activation with SP600125 enhanced the cardioprotection by insulin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
17629357-6	2007	LY294002 (a PI3K inhibitor) inhibited the effect of geniposide increasing of Bcl-2 level by activation of MAPK, MEK and c-Raf phosphorylation in hydrogen peroxide treated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2, apoptosis regulator	Rattus norvegicus	77-82
17629357-6	2007	LY294002 (a PI3K inhibitor) inhibited the effect of geniposide increasing of Bcl-2 level by activation of MAPK, MEK and c-Raf phosphorylation in hydrogen peroxide treated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	120-125
17823925-8	2007	While knockdown of IAPs using siRNA did not mimic the effects of resveratrol, inhibition of Akt phosphorylation using LY294002 sensitized PC-3 cells to TRAIL induced apoptosis but not to etoposide or tunicamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	TNF superfamily member 10	Homo sapiens	152-157
17719561-6	2007	PI3K inhibitor, LY294002 attenuated ghrelin"s inhibitory effect on caspase-3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	caspase 3	Homo sapiens	67-76
17407140-10	2007	PI3K inhibitor LY294002 upregulated p27(Kip1) at post-translational level and downregulate Skp2 at mRNA level, which could mimic the effects of integrin beta1 overexpression on p27(Kip1) and Skp2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cyclin dependent kinase inhibitor 1B	Homo sapiens	40-44
17407140-10	2007	PI3K inhibitor LY294002 upregulated p27(Kip1) at post-translational level and downregulate Skp2 at mRNA level, which could mimic the effects of integrin beta1 overexpression on p27(Kip1) and Skp2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	S-phase kinase associated protein 2	Homo sapiens	91-95
17407140-10	2007	PI3K inhibitor LY294002 upregulated p27(Kip1) at post-translational level and downregulate Skp2 at mRNA level, which could mimic the effects of integrin beta1 overexpression on p27(Kip1) and Skp2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	integrin subunit beta 1	Homo sapiens	144-158
17407140-10	2007	PI3K inhibitor LY294002 upregulated p27(Kip1) at post-translational level and downregulate Skp2 at mRNA level, which could mimic the effects of integrin beta1 overexpression on p27(Kip1) and Skp2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	dynactin subunit 6	Homo sapiens	177-180
17407140-10	2007	PI3K inhibitor LY294002 upregulated p27(Kip1) at post-translational level and downregulate Skp2 at mRNA level, which could mimic the effects of integrin beta1 overexpression on p27(Kip1) and Skp2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cyclin dependent kinase inhibitor 1B	Homo sapiens	181-185
17407140-10	2007	PI3K inhibitor LY294002 upregulated p27(Kip1) at post-translational level and downregulate Skp2 at mRNA level, which could mimic the effects of integrin beta1 overexpression on p27(Kip1) and Skp2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	S-phase kinase associated protein 2	Homo sapiens	191-195
17596297-5	2007	Furthermore, activity was suppressed by phosphatidylinositol bisphosphate (PIP(2)) chelator (neomycin) or phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002); in contrast, activity, which was partially inhibited by ERK kinase inhibitor (U0126, PD98059), was unaffected by PLC inhibitor (U73122).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	106-135
17596297-5	2007	Furthermore, activity was suppressed by phosphatidylinositol bisphosphate (PIP(2)) chelator (neomycin) or phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002); in contrast, activity, which was partially inhibited by ERK kinase inhibitor (U0126, PD98059), was unaffected by PLC inhibitor (U73122).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	heparan sulfate proteoglycan 2	Homo sapiens	278-281
17581928-9	2007	A pretreatment with STAT3 inhibitor LY 294002, an Akt inhibitor, or MAPK inhibitors significantly blocked the IL-6-induced increase in alpha-MG uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-45	signal transducer and activator of transcription 3	Homo sapiens	20-25
17581928-9	2007	A pretreatment with STAT3 inhibitor LY 294002, an Akt inhibitor, or MAPK inhibitors significantly blocked the IL-6-induced increase in alpha-MG uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-45	interleukin 6	Homo sapiens	110-114
17964299-6	2007	The suppressive effect of BSO on PEPCK mRNA level is also reversed through co-treatment with either SB210290, a specific p38 kinase inhibitor, or wortmannin and LY294002, the well-established PI-3 kinase inhibitors, suggesting the involvement of these kinases in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	33-38
17660326-4	2007	Treatment with actinomycin D, cycloheximide, the phosphatidylinositol 3-kinase inhibitors LY-294002 and wortmannin or the reactive oxygen species scavenger diphenyleneiodonium inhibited the FBS-dependent induction of HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-99	hypoxia-inducible factor 1-alpha	Oryctolagus cuniculus	217-227
17917251-4	2007	Moreover, acetylation of STAT3 at Lys-685 was suppressed by PI3K inhibitor LY294002, or a dominant negative Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	signal transducer and activator of transcription 3	Homo sapiens	25-30
17631873-7	2007	NaHS increased Akt phosphorylation and this effect was also blocked by either LY 294002 or wortmannin (25 nmol/l).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-87	thymoma viral proto-oncogene 1	Mus musculus	15-18
17585340-3	2007	We recently demonstrated that the phosphatidylinositide-3-kinase (PI3K) inhibitor, LY294002, and its inactive analog LY303511, sensitized tumor cells to vincristine-induced apoptosis, independent of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	34-64
17599831-8	2007	Experiments using the AKT phosphorylation inhibitor LY294002 indicate that AKT phosphorylation downregulates cofilin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	22-25
17585340-3	2007	We recently demonstrated that the phosphatidylinositide-3-kinase (PI3K) inhibitor, LY294002, and its inactive analog LY303511, sensitized tumor cells to vincristine-induced apoptosis, independent of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	AKT serine/threonine kinase 1	Homo sapiens	204-207
17643958-5	2007	In addition, Cch-induced MAPK/ERK phosphorylation was partially inhibited by LY294002 and wortmannin, two selective inhibitors of phosphatidylinositol 3-kinase (PI3K), tyrphostin AG1478, a specific inhibitor of epidermal growth factor receptor (EGFR) kinase, and (-)-perillic acid, a post-translational inhibitor of small G-proteins isoprenylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	mitogen-activated protein kinase 1	Homo sapiens	30-33
17643958-5	2007	In addition, Cch-induced MAPK/ERK phosphorylation was partially inhibited by LY294002 and wortmannin, two selective inhibitors of phosphatidylinositol 3-kinase (PI3K), tyrphostin AG1478, a specific inhibitor of epidermal growth factor receptor (EGFR) kinase, and (-)-perillic acid, a post-translational inhibitor of small G-proteins isoprenylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	epidermal growth factor receptor	Homo sapiens	211-243
17643958-5	2007	In addition, Cch-induced MAPK/ERK phosphorylation was partially inhibited by LY294002 and wortmannin, two selective inhibitors of phosphatidylinositol 3-kinase (PI3K), tyrphostin AG1478, a specific inhibitor of epidermal growth factor receptor (EGFR) kinase, and (-)-perillic acid, a post-translational inhibitor of small G-proteins isoprenylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	epidermal growth factor receptor	Homo sapiens	245-249
17908985-15	2007	An additional feature of Us3 mutants is enhanced Akt activation compared with wild-type infection, which sensitizes cells to phosphatidylinositol 3-kinase-Akt inhibitors (LY294002, Akt inhibitor IV), shown by synergistic antitumoral activity in vitro and enhanced efficacy in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	serine/threonine protein kinase US3	Human alphaherpesvirus 1	25-28
17908985-15	2007	An additional feature of Us3 mutants is enhanced Akt activation compared with wild-type infection, which sensitizes cells to phosphatidylinositol 3-kinase-Akt inhibitors (LY294002, Akt inhibitor IV), shown by synergistic antitumoral activity in vitro and enhanced efficacy in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	AKT serine/threonine kinase 1	Homo sapiens	49-52
17599831-8	2007	Experiments using the AKT phosphorylation inhibitor LY294002 indicate that AKT phosphorylation downregulates cofilin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	75-78
17599831-8	2007	Experiments using the AKT phosphorylation inhibitor LY294002 indicate that AKT phosphorylation downregulates cofilin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	cofilin 1	Homo sapiens	109-116
17599831-10	2007	LY294002 also stabilized Lyn from phosphorylated AKT, suggesting an interaction between Lyn and AKT phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
17599831-10	2007	LY294002 also stabilized Lyn from phosphorylated AKT, suggesting an interaction between Lyn and AKT phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	49-52
17599831-10	2007	LY294002 also stabilized Lyn from phosphorylated AKT, suggesting an interaction between Lyn and AKT phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	88-91
17599831-10	2007	LY294002 also stabilized Lyn from phosphorylated AKT, suggesting an interaction between Lyn and AKT phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	96-99
17646428-7	2007	In addition, a phosphoinositide 3-kinase inhibitor, LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], a specific AKT inhibitor, and 0.2 to 20 microM CA4 displayed a similar response profile on p-AKT-positive cells, suggesting that CA4-induced effect was mediated by inhibition of the PI3 kinase/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	139-142
17786300-9	2007	A dominant negative AKT or the phosphatidylinositol 3-kinase inhibitor, LY294002, also strongly inhibited survivin promoter activity, providing further evidence to support the hypothesis that the inhibitory effect of EGCG on survivin is mediated via the AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	254-257
17372934-9	2007	Basal Akt activation was inhibited 90% by LY294002 and 70% by Akt inhibitor IV.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	AKT serine/threonine kinase 1	Homo sapiens	6-9
17623046-7	2007	Inhibitors of PI3K (LY294002) or mTOR (rapamycin) also completely blocked STEP translation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	protein tyrosine phosphatase non-receptor type 5	Homo sapiens	74-78
17592496-8	2007	PD98059, U0126 and LY294002 not only abolished IL-12-induced IL-4 release but also inhibited IL-12-induced phosphorylation of extracellular signal-regulated kinase and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	interleukin 4	Mus musculus	61-65
17592496-8	2007	PD98059, U0126 and LY294002 not only abolished IL-12-induced IL-4 release but also inhibited IL-12-induced phosphorylation of extracellular signal-regulated kinase and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	thymoma viral proto-oncogene 1	Mus musculus	168-171
17623045-5	2007	The H(3)R-mediated activation of Akt can be inhibited by the H(3)R inverse agonist thioperamide, and by Wortmannin, LY294002 and PTX, suggesting the observed Akt activation occurs via a G(i/o)-mediated activation of phosphoinositide-3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
17623045-5	2007	The H(3)R-mediated activation of Akt can be inhibited by the H(3)R inverse agonist thioperamide, and by Wortmannin, LY294002 and PTX, suggesting the observed Akt activation occurs via a G(i/o)-mediated activation of phosphoinositide-3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Rattus norvegicus	158-161
17646428-7	2007	In addition, a phosphoinositide 3-kinase inhibitor, LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], a specific AKT inhibitor, and 0.2 to 20 microM CA4 displayed a similar response profile on p-AKT-positive cells, suggesting that CA4-induced effect was mediated by inhibition of the PI3 kinase/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	carbonic anhydrase 4	Homo sapiens	175-178
17646428-7	2007	In addition, a phosphoinositide 3-kinase inhibitor, LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], a specific AKT inhibitor, and 0.2 to 20 microM CA4 displayed a similar response profile on p-AKT-positive cells, suggesting that CA4-induced effect was mediated by inhibition of the PI3 kinase/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	219-224
17646428-7	2007	In addition, a phosphoinositide 3-kinase inhibitor, LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], a specific AKT inhibitor, and 0.2 to 20 microM CA4 displayed a similar response profile on p-AKT-positive cells, suggesting that CA4-induced effect was mediated by inhibition of the PI3 kinase/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	carbonic anhydrase 4	Homo sapiens	257-260
17646428-7	2007	In addition, a phosphoinositide 3-kinase inhibitor, LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], a specific AKT inhibitor, and 0.2 to 20 microM CA4 displayed a similar response profile on p-AKT-positive cells, suggesting that CA4-induced effect was mediated by inhibition of the PI3 kinase/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	221-224
18007078-5	2007	N(w)-nitro-L- arginine methyl ester (L-NAME, eNOS synthase inhibitor) blocked the rosiglitazone-induced NO formation; LY294002 (a PI3K inhibitor) prevented the NO production; and the phosphorylation of eNOS and PKB was induced by rosiglitazone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	nitric oxide synthase 3	Homo sapiens	202-206
17549607-9	2007	U0126 (a MEK1/2 inhibitor) or LY294002 (a PI3K inhibitor) was added to ST2 and MC3T3-E1 cells, and was found to inhibit RANKL mRNA and RANKL protein expression in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	interleukin 1 receptor-like 1	Mus musculus	71-74
17549607-9	2007	U0126 (a MEK1/2 inhibitor) or LY294002 (a PI3K inhibitor) was added to ST2 and MC3T3-E1 cells, and was found to inhibit RANKL mRNA and RANKL protein expression in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	120-125
17549607-9	2007	U0126 (a MEK1/2 inhibitor) or LY294002 (a PI3K inhibitor) was added to ST2 and MC3T3-E1 cells, and was found to inhibit RANKL mRNA and RANKL protein expression in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	135-140
17557191-3	2007	However, the two PI3K inhibitors LY294002 and wortmannin treatment up-regulated beta1,4GT1 through enhancing Sp1 protein expression and consequently increased CHX-induced SMMC-7721 cells apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	80-90
17557191-6	2007	Taken together, PI3K inhibitors LY294002 and wortmannin up-regulated beta1,4GT1 and enhanced CHX-induced apoptosis in SMMC-7721 cells, which suggested that PI3K inhibitors might have therapeutic potential when combined with CHX in the treatment of hepatoma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	69-79
17804301-9	2007	Cell viability was increased by Ang II 10(-6) M and decreased by Ang II 10(-4) M. It was further decreased by pre-treatment with PI-3K/Akt inhibitor LY294002, but unaffected by p38-MAPK inhibitor SB202190.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	angiotensinogen	Homo sapiens	32-38
17804301-9	2007	Cell viability was increased by Ang II 10(-6) M and decreased by Ang II 10(-4) M. It was further decreased by pre-treatment with PI-3K/Akt inhibitor LY294002, but unaffected by p38-MAPK inhibitor SB202190.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	angiotensinogen	Homo sapiens	65-71
17804301-9	2007	Cell viability was increased by Ang II 10(-6) M and decreased by Ang II 10(-4) M. It was further decreased by pre-treatment with PI-3K/Akt inhibitor LY294002, but unaffected by p38-MAPK inhibitor SB202190.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	AKT serine/threonine kinase 1	Homo sapiens	135-138
18194602-5	2007	LY294002, a specific inhibitor of PI-3K, effectively blocked Akt phosphorylation induced by AMP-PNP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	61-64
18007078-5	2007	N(w)-nitro-L- arginine methyl ester (L-NAME, eNOS synthase inhibitor) blocked the rosiglitazone-induced NO formation; LY294002 (a PI3K inhibitor) prevented the NO production; and the phosphorylation of eNOS and PKB was induced by rosiglitazone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	protein tyrosine kinase 2 beta	Homo sapiens	211-214
17631500-5	2007	Exogenous HER2 expression in MDA-MB-231 cells induced the expression of FASN and ACCalpha, and the HER2-mediated increase in ACCalpha and FASN was inhibited by both LY294002, a phosphatidylinositol 3-kinase inhibitor, and rapamycin, a mammalian target of rapamycin (mTOR) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	erb-b2 receptor tyrosine kinase 2	Homo sapiens	10-14
17890906-5	2007	Our results show that direct inhibition of PI3K/Akt in G(2)-arrested cells by wortmannin or LY294002 strongly enhanced the cytotoxicity of cisplatin without influencing the G(2) checkpoint.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	48-51
17420722-10	2007	Treatment of tumor cells with LY294002 or with Akt siRNA, but not control siRNA, resulted in inhibition of Bcl-(xL) expression and sensitization to drug-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	BCL2 like 1	Homo sapiens	107-114
17513037-6	2007	The zinc-induced inhibition of Notch signaling can be rescued via pretreatment with wortmannin or LY294002, both of which are specific PI3K signaling pathway inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	notch receptor 1	Homo sapiens	31-36
17420722-9	2007	The role of the Akt pathway in the regulation of resistance was corroborated by the use of the Akt inhibitor, LY294002, and by transfection with siRNA Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Homo sapiens	16-19
17631500-5	2007	Exogenous HER2 expression in MDA-MB-231 cells induced the expression of FASN and ACCalpha, and the HER2-mediated increase in ACCalpha and FASN was inhibited by both LY294002, a phosphatidylinositol 3-kinase inhibitor, and rapamycin, a mammalian target of rapamycin (mTOR) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	fatty acid synthase	Homo sapiens	72-76
17631500-5	2007	Exogenous HER2 expression in MDA-MB-231 cells induced the expression of FASN and ACCalpha, and the HER2-mediated increase in ACCalpha and FASN was inhibited by both LY294002, a phosphatidylinositol 3-kinase inhibitor, and rapamycin, a mammalian target of rapamycin (mTOR) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	acetyl-CoA carboxylase alpha	Homo sapiens	81-89
17631500-5	2007	Exogenous HER2 expression in MDA-MB-231 cells induced the expression of FASN and ACCalpha, and the HER2-mediated increase in ACCalpha and FASN was inhibited by both LY294002, a phosphatidylinositol 3-kinase inhibitor, and rapamycin, a mammalian target of rapamycin (mTOR) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	erb-b2 receptor tyrosine kinase 2	Homo sapiens	99-103
17631500-5	2007	Exogenous HER2 expression in MDA-MB-231 cells induced the expression of FASN and ACCalpha, and the HER2-mediated increase in ACCalpha and FASN was inhibited by both LY294002, a phosphatidylinositol 3-kinase inhibitor, and rapamycin, a mammalian target of rapamycin (mTOR) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	acetyl-CoA carboxylase alpha	Homo sapiens	125-133
17631500-5	2007	Exogenous HER2 expression in MDA-MB-231 cells induced the expression of FASN and ACCalpha, and the HER2-mediated increase in ACCalpha and FASN was inhibited by both LY294002, a phosphatidylinositol 3-kinase inhibitor, and rapamycin, a mammalian target of rapamycin (mTOR) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	fatty acid synthase	Homo sapiens	138-142
17631500-5	2007	Exogenous HER2 expression in MDA-MB-231 cells induced the expression of FASN and ACCalpha, and the HER2-mediated increase in ACCalpha and FASN was inhibited by both LY294002, a phosphatidylinositol 3-kinase inhibitor, and rapamycin, a mammalian target of rapamycin (mTOR) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	mechanistic target of rapamycin kinase	Homo sapiens	235-264
17631500-5	2007	Exogenous HER2 expression in MDA-MB-231 cells induced the expression of FASN and ACCalpha, and the HER2-mediated increase in ACCalpha and FASN was inhibited by both LY294002, a phosphatidylinositol 3-kinase inhibitor, and rapamycin, a mammalian target of rapamycin (mTOR) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	mechanistic target of rapamycin kinase	Homo sapiens	266-270
17566113-7	2007	LA"s antiapoptotic activity was reduced by PI 3-kinase inhibitors (wortmannin, LY-294002), being in line with LA-induced Akt phosphorylation (Ser(437), +159 +/- 43%; Thr(308), +98 +/- 25%; P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-88	AKT serine/threonine kinase 1	Homo sapiens	121-124
17825046-6	2007	Treatment of mouse embryonic fibroblasts (MEFs) with Con A induces secretion of matrix metalloproteinase (MMP)-9, a phenomenon that is inhibited in cells expressing YF mutant of SHPS-1, a dominant negative form of Akt or in cells pre-treated with an Akt inhibitor, LY294002 or extracellular-signal regulated kinase (Erk) inhibitor, U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	265-273	signal-regulatory protein alpha	Mus musculus	178-184
17522977-6	2007	In addition, significant (p &lt; 0.05) elevation of Akt phosphorylation in SMC following exposure to cyclic pressure and lack of pressure-induced SMC hyperplasia in the presence of PI3K inhibitors, wortmannin and LY294002, indicated the involvement of the PI3K/Akt pathway in the proliferative response of SMC to cyclic pressure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
17688959-9	2007	By exploiting specific chemical inhibitors of the MAPK/ERK and PI3K/Akt signaling pathways, UO126 and Ly294002, respectively, we demonstrate that Shh-induced Akt phosphorylation, but not that of MAPK/ERK, is required for its promotive effects on muscle cell proliferation and differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	sonic hedgehog	Mus musculus	146-149
17467844-5	2007	These insulin actions were modestly inhibited by the application of LY294002, the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, but not completely, suggesting that another mechanism is also involved.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	insulin	Homo sapiens	6-13
17540722-8	2007	Inhibition of PI3K/Akt activity with PI3K inhibitor LY294002 or by expressing the dominant negative p85 or Akt prevented the HG-enhanced PPAR gamma-dependent adipogenic induction of lipid accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	thymoma viral proto-oncogene 1	Mus musculus	19-22
17540722-8	2007	Inhibition of PI3K/Akt activity with PI3K inhibitor LY294002 or by expressing the dominant negative p85 or Akt prevented the HG-enhanced PPAR gamma-dependent adipogenic induction of lipid accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	peroxisome proliferator activated receptor gamma	Mus musculus	137-147
17825046-6	2007	Treatment of mouse embryonic fibroblasts (MEFs) with Con A induces secretion of matrix metalloproteinase (MMP)-9, a phenomenon that is inhibited in cells expressing YF mutant of SHPS-1, a dominant negative form of Akt or in cells pre-treated with an Akt inhibitor, LY294002 or extracellular-signal regulated kinase (Erk) inhibitor, U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	265-273	matrix metallopeptidase 9	Mus musculus	80-112
17576198-11	2007	The PI3K inhibitor LY294002 suppressed HIF-1alpha protein expression, HIF-1 DNA-binding and HIF-1 transcriptional activity in HTLV-1-infected T-cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-49
17576198-11	2007	The PI3K inhibitor LY294002 suppressed HIF-1alpha protein expression, HIF-1 DNA-binding and HIF-1 transcriptional activity in HTLV-1-infected T-cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-44
17576198-11	2007	The PI3K inhibitor LY294002 suppressed HIF-1alpha protein expression, HIF-1 DNA-binding and HIF-1 transcriptional activity in HTLV-1-infected T-cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-75
18481202-9	2007	We also demonstrated that insulin induction of SCD1 gene expression and promoter activity is abolished by pre-incubation of cells with specific inhibitors of both PI3-kinase (LY294002) and mTor (Rapamycin) or by over-expression of a dominant negative mutant of PI3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	insulin	Gallus gallus	26-33
17372916-5	2007	LY294002 and wortmannin, specific inhibitors of PI3 kinase, and PD98059, a specific inhibitor of mitogen-activated protein (MAP) kinase, were used to examine the signaling pathway of C/EBPalpha upregulated by IGF-II.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CCAAT enhancer binding protein alpha	Homo sapiens	183-193
17372916-11	2007	LY294002 and wortmannin suppressed expression of C/EBPalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CCAAT enhancer binding protein alpha	Homo sapiens	49-59
17372916-13	2007	LY294002 and wortmannin suppressed the promoter activity of C/EBPalpha while PD98059 did not, suggesting that activation of the promoter was mediated by PI3 kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CCAAT enhancer binding protein alpha	Homo sapiens	60-70
17878755-5	2007	The migration can also be nearly completely blocked by phosphoinositide 3-kinase inhibitors (LY294002 and wortmannin) and eNOS inhibitor (N-nitro-arginine methyl ester), whereas mitogen-activated protein kinase/ERK inhibitor (PD98059) had no significant effect on SDF-1alpha-induced migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	mitogen-activated protein kinase 1	Homo sapiens	211-214
18481202-9	2007	We also demonstrated that insulin induction of SCD1 gene expression and promoter activity is abolished by pre-incubation of cells with specific inhibitors of both PI3-kinase (LY294002) and mTor (Rapamycin) or by over-expression of a dominant negative mutant of PI3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	stearoyl-CoA desaturase	Gallus gallus	47-51
17675106-10	2007	NS-398 increased phosphorylation of Akt, and LY-294002, a specific PI(3) kinase inhibitor, inhibited NS-398-induced HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-54	heme oxygenase 1	Homo sapiens	116-120
17562852-6	2007	Leptin also significantly phosphorylated Akt by 130 +/- 30%, which was inhibited by the PI3K inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-151	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
17562852-6	2007	Leptin also significantly phosphorylated Akt by 130 +/- 30%, which was inhibited by the PI3K inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
17562852-7	2007	RhoA/ROCK and PI3K/Akt activation was associated with a significant increase in RPV wet weight (11 +/- 1%), protein synthesis (45 +/- 7%), SRF expression (136 +/- 11%), and polymerization of actin, as reflected by an increase in the F-/G-actin ratio, effects that were significantly attenuated by a leptin receptor (leptin obese receptor) antibody, the ROCK inhibitor (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) (Y-27632) as well as the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	453-461	ras homolog family member A	Rattus norvegicus	0-4
17562852-7	2007	RhoA/ROCK and PI3K/Akt activation was associated with a significant increase in RPV wet weight (11 +/- 1%), protein synthesis (45 +/- 7%), SRF expression (136 +/- 11%), and polymerization of actin, as reflected by an increase in the F-/G-actin ratio, effects that were significantly attenuated by a leptin receptor (leptin obese receptor) antibody, the ROCK inhibitor (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) (Y-27632) as well as the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	453-461	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
17582000-6	2007	Furthermore, the Ras inhibitors manumycin A and a dominant-negative form of Ras (RasN17) and the PI3-K inhibitor LY294002 blocked LMP2A-mediated Akt phosphorylation and anchorage-independent cell growth in HSC-39 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	LMP2A	Human gammaherpesvirus 4	130-135
17582000-6	2007	Furthermore, the Ras inhibitors manumycin A and a dominant-negative form of Ras (RasN17) and the PI3-K inhibitor LY294002 blocked LMP2A-mediated Akt phosphorylation and anchorage-independent cell growth in HSC-39 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Homo sapiens	145-148
17548887-4	2007	LY294002, an inhibitor of phosphatidylinositide 3-OH kinase (PI3K) and of Akt phosphorylation, inhibited apoE-HDL secretion but not cholesterol biosynthesis, whereas U0126, an inhibitor of MEK and of ERK phosphorylation, inhibited cholesterol biosynthesis but not apoE-HDL secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
17548887-4	2007	LY294002, an inhibitor of phosphatidylinositide 3-OH kinase (PI3K) and of Akt phosphorylation, inhibited apoE-HDL secretion but not cholesterol biosynthesis, whereas U0126, an inhibitor of MEK and of ERK phosphorylation, inhibited cholesterol biosynthesis but not apoE-HDL secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	apolipoprotein E	Rattus norvegicus	105-109
17548887-4	2007	LY294002, an inhibitor of phosphatidylinositide 3-OH kinase (PI3K) and of Akt phosphorylation, inhibited apoE-HDL secretion but not cholesterol biosynthesis, whereas U0126, an inhibitor of MEK and of ERK phosphorylation, inhibited cholesterol biosynthesis but not apoE-HDL secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Eph receptor B1	Rattus norvegicus	200-203
17548887-4	2007	LY294002, an inhibitor of phosphatidylinositide 3-OH kinase (PI3K) and of Akt phosphorylation, inhibited apoE-HDL secretion but not cholesterol biosynthesis, whereas U0126, an inhibitor of MEK and of ERK phosphorylation, inhibited cholesterol biosynthesis but not apoE-HDL secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	apolipoprotein E	Rattus norvegicus	264-268
18404453-10	2007	The protection by guanosine was also abolished by the selective inhibitor of the enzyme PI-3-K/Akt/PKB (LY294002), confirming that this pathway plays a decisive role in this effect of guanosine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	AKT serine/threonine kinase 1	Homo sapiens	99-102
17562705-2	2007	Several small molecules such as LY294002 inhibit mTOR kinase activity, but they also inhibit phosphatidylinositol 3-kinase (PI3K) at similar concentrations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	mechanistic target of rapamycin kinase	Homo sapiens	49-53
17562705-2	2007	Several small molecules such as LY294002 inhibit mTOR kinase activity, but they also inhibit phosphatidylinositol 3-kinase (PI3K) at similar concentrations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	93-122
17508273-5	2007	The anti-apoptotic effect of EPO was abrogated by co-treatment with LY294002, the specific blocker of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	erythropoietin	Rattus norvegicus	29-32
17310986-6	2007	Activation was abolished by kinase inhibitors Ly294002 and PP2 and in Src/Yes/Fyn(SYF)(-/-) and CD74(-/-)(MEFs), while being enhanced in CD74-overexpressing MEFs, demonstrating that the MIF-induced Akt pathway encompasses signaling through the MIF receptor CD74 and the upstream kinases Src and PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	CD74 molecule	Homo sapiens	137-141
17310986-6	2007	Activation was abolished by kinase inhibitors Ly294002 and PP2 and in Src/Yes/Fyn(SYF)(-/-) and CD74(-/-)(MEFs), while being enhanced in CD74-overexpressing MEFs, demonstrating that the MIF-induced Akt pathway encompasses signaling through the MIF receptor CD74 and the upstream kinases Src and PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	macrophage migration inhibitory factor	Homo sapiens	186-189
17310986-6	2007	Activation was abolished by kinase inhibitors Ly294002 and PP2 and in Src/Yes/Fyn(SYF)(-/-) and CD74(-/-)(MEFs), while being enhanced in CD74-overexpressing MEFs, demonstrating that the MIF-induced Akt pathway encompasses signaling through the MIF receptor CD74 and the upstream kinases Src and PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	198-201
17310986-6	2007	Activation was abolished by kinase inhibitors Ly294002 and PP2 and in Src/Yes/Fyn(SYF)(-/-) and CD74(-/-)(MEFs), while being enhanced in CD74-overexpressing MEFs, demonstrating that the MIF-induced Akt pathway encompasses signaling through the MIF receptor CD74 and the upstream kinases Src and PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	macrophage migration inhibitory factor	Homo sapiens	244-247
17310986-6	2007	Activation was abolished by kinase inhibitors Ly294002 and PP2 and in Src/Yes/Fyn(SYF)(-/-) and CD74(-/-)(MEFs), while being enhanced in CD74-overexpressing MEFs, demonstrating that the MIF-induced Akt pathway encompasses signaling through the MIF receptor CD74 and the upstream kinases Src and PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	CD74 molecule	Homo sapiens	137-141
17310986-6	2007	Activation was abolished by kinase inhibitors Ly294002 and PP2 and in Src/Yes/Fyn(SYF)(-/-) and CD74(-/-)(MEFs), while being enhanced in CD74-overexpressing MEFs, demonstrating that the MIF-induced Akt pathway encompasses signaling through the MIF receptor CD74 and the upstream kinases Src and PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	287-290
17384686-7	2007	Pertussis toxin and LY294002 inhibition demonstrated that galanin and GALR1 induce ERK1/2 activation via Galphai, not the PI3K pathway-linked to the Gbetagamma subunit.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	galanin receptor 1	Homo sapiens	70-75
17508273-6	2007	The effects of EPO on GSK-3beta and caspase-3 activities were also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	erythropoietin	Rattus norvegicus	15-18
17508273-6	2007	The effects of EPO on GSK-3beta and caspase-3 activities were also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	glycogen synthase kinase 3 beta	Rattus norvegicus	22-31
17508273-6	2007	The effects of EPO on GSK-3beta and caspase-3 activities were also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	caspase 3	Rattus norvegicus	36-45
17666799-12	2007	ABE also triggered the downregulation of Akt, and combined treatment with LY294002 (an inhibitor of Akt) significantly decreased cell viability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	100-103
17641277-6	2007	Pharmacological inhibition of phosphatidylinositol (PI)-3 kinase by LY294002 partially reversed inhibition of adiponectin gene expression by CRP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	adiponectin, C1Q and collagen domain containing	Homo sapiens	110-121
17462862-8	2007	Moreover, although MRC5CV1 cells were much more resistant to CPT compared with AT5BIVA, wortmannin and LY294002 significantly increased the chemosensitivity of MRC5CV1 cells to CPT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	choline phosphotransferase 1	Homo sapiens	177-180
17635516-5	2007	We found that CDK4 activity was restricted by either inhibiting growth factor induced cyclin D1-induction with the PI3K inhibitor LY294002, or by transient transfection with a dominant negative CDK4 mutant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	cyclin-dependent kinase 4	Rattus norvegicus	14-18
17635516-5	2007	We found that CDK4 activity was restricted by either inhibiting growth factor induced cyclin D1-induction with the PI3K inhibitor LY294002, or by transient transfection with a dominant negative CDK4 mutant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	cyclin D1	Rattus norvegicus	86-95
17611702-8	2007	Inhibition of p38(MAPK) signaling by SB202190 completely abrogated LPA-induced uPA secretion, while inhibition of the p42/44(MAPK) or PI3K pathways with PD98059 or wortmannin and LY294002, respectively, decreased but did not completely block uPA secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	mitogen-activated protein kinase 14	Homo sapiens	14-17
17376651-4	2007	Phosphatidylinositol kinase (PI3K) inhibitors, Wortmannin and LY294002 and Akt inhibitor (NL-71-101) significantly inhibited TGF-beta-induced Akt phosphorylation, TIMP-3 expression, TIMP-3 promoter (-940 to +376)-driven luciferase activity and Sp1 transcription factor binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	transforming growth factor beta 1	Homo sapiens	125-133
17376651-4	2007	Phosphatidylinositol kinase (PI3K) inhibitors, Wortmannin and LY294002 and Akt inhibitor (NL-71-101) significantly inhibited TGF-beta-induced Akt phosphorylation, TIMP-3 expression, TIMP-3 promoter (-940 to +376)-driven luciferase activity and Sp1 transcription factor binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	AKT serine/threonine kinase 1	Homo sapiens	142-145
17376651-4	2007	Phosphatidylinositol kinase (PI3K) inhibitors, Wortmannin and LY294002 and Akt inhibitor (NL-71-101) significantly inhibited TGF-beta-induced Akt phosphorylation, TIMP-3 expression, TIMP-3 promoter (-940 to +376)-driven luciferase activity and Sp1 transcription factor binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	TIMP metallopeptidase inhibitor 3	Homo sapiens	163-169
17376651-4	2007	Phosphatidylinositol kinase (PI3K) inhibitors, Wortmannin and LY294002 and Akt inhibitor (NL-71-101) significantly inhibited TGF-beta-induced Akt phosphorylation, TIMP-3 expression, TIMP-3 promoter (-940 to +376)-driven luciferase activity and Sp1 transcription factor binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	TIMP metallopeptidase inhibitor 3	Homo sapiens	182-188
17641277-6	2007	Pharmacological inhibition of phosphatidylinositol (PI)-3 kinase by LY294002 partially reversed inhibition of adiponectin gene expression by CRP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	C-reactive protein	Homo sapiens	141-144
17646933-8	2007	Introduction of Ep-CAM in the epithelial cells caused abrogation of N-cadherin mediated cell-cell adhesion, which could be inhibited by Pi3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	epithelial cell adhesion molecule	Homo sapiens	16-22
17646933-8	2007	Introduction of Ep-CAM in the epithelial cells caused abrogation of N-cadherin mediated cell-cell adhesion, which could be inhibited by Pi3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	cadherin 2	Homo sapiens	68-78
17618624-4	2007	WIPI-1 puncta-formation is inhibited by wortmannin and LY294002, and PI(3)P-binding-deficient WIPI-1 is puncta-formation-incompetent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	WD repeat domain, phosphoinositide interacting 1	Homo sapiens	0-6
17286201-2	2007	Here, we report a novel finding that PI 3-K inhibition by LY294002 significantly increases p21WAF1/Cip1 expression in PMA-stimulated human leukemia cells NB4 and THP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	cyclin dependent kinase inhibitor 1A	Homo sapiens	99-103
17286201-2	2007	Here, we report a novel finding that PI 3-K inhibition by LY294002 significantly increases p21WAF1/Cip1 expression in PMA-stimulated human leukemia cells NB4 and THP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	GLI family zinc finger 2	Homo sapiens	162-166
17286201-3	2007	LY294002 potentiated expression of p21WAF1/Cip1 via a p53-independent mechanism and did not affect mitogen activated protein kinase (MAPK) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	43-47
17286201-3	2007	LY294002 potentiated expression of p21WAF1/Cip1 via a p53-independent mechanism and did not affect mitogen activated protein kinase (MAPK) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor protein p53	Homo sapiens	54-57
17049600-6	2007	Phosphatidylinositol 3-kinase (PI3K) and Akt were activated and LY294002 downregulated XIAP and increased apoptosis in HL-60 cells co-cultured with BMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-29
17049600-6	2007	Phosphatidylinositol 3-kinase (PI3K) and Akt were activated and LY294002 downregulated XIAP and increased apoptosis in HL-60 cells co-cultured with BMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	X-linked inhibitor of apoptosis	Homo sapiens	87-91
17626748-7	2007	The small hairpin RNA (shRNA) targeting DNA-PKcs and a competitive DNA-PKcs inhibitor LY294002 were used to inhibit DNA-PKcs expression and activity in cervical carcinoma cell line HeLa.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	67-75
17537411-11	2007	Moreover, pretreatment with either LY294002, a phosphatidylinositol-3 kinase (PI-3K) inhibitor or L-NAME, a NOS inhibitor, abolished the exercise-induced sensitization of myocardial contractile response to insulin, insulin-induced NO production and phosphorylation of Akt and eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	47-76
17537411-11	2007	Moreover, pretreatment with either LY294002, a phosphatidylinositol-3 kinase (PI-3K) inhibitor or L-NAME, a NOS inhibitor, abolished the exercise-induced sensitization of myocardial contractile response to insulin, insulin-induced NO production and phosphorylation of Akt and eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Rattus norvegicus	268-271
17553490-9	2007	During prolonged exposure to agonist, LY294002 slowed the degradation rate of beta(2)-adrenergic receptors and caused the accumulation of receptors within rab7-positive vesicles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	RAB7B, member RAS oncogene family	Homo sapiens	155-159
17626748-7	2007	The small hairpin RNA (shRNA) targeting DNA-PKcs and a competitive DNA-PKcs inhibitor LY294002 were used to inhibit DNA-PKcs expression and activity in cervical carcinoma cell line HeLa.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	67-75
17459944-6	2007	Insulin effects on protein accumulation and cell morphology were abrogated by combined pretreatment with the Rho kinase inhibitor Y-27632 (1 microM) or the PI 3-kinase inhibitor LY-294002 (10 microM), indicating that insulin increases the expression of contractile phenotypic markers in BTSM in a Rho kinase- and PI 3-kinase-dependent fashion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-187	insulin	Bos taurus	0-7
17488805-9	2007	Effects of PRL on Caco-2 monolayer were abolished by PI3K inhibitors (LY-294002 and wortmannin), but not by inhibitors of MEK (U-0126) or JAK2 (AG-490).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-79	prolactin	Rattus norvegicus	11-14
17459944-6	2007	Insulin effects on protein accumulation and cell morphology were abrogated by combined pretreatment with the Rho kinase inhibitor Y-27632 (1 microM) or the PI 3-kinase inhibitor LY-294002 (10 microM), indicating that insulin increases the expression of contractile phenotypic markers in BTSM in a Rho kinase- and PI 3-kinase-dependent fashion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-187	elafin	Bos taurus	156-160
17459944-6	2007	Insulin effects on protein accumulation and cell morphology were abrogated by combined pretreatment with the Rho kinase inhibitor Y-27632 (1 microM) or the PI 3-kinase inhibitor LY-294002 (10 microM), indicating that insulin increases the expression of contractile phenotypic markers in BTSM in a Rho kinase- and PI 3-kinase-dependent fashion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-187	elafin	Bos taurus	313-317
17372272-8	2007	Additionally, we describe that the phosphorylation of AKT and eIF4G, as well as the elevation of the Mst1 and RanBP2 protein levels, can be inhibited in vivo in transgenic animals by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	AKT serine/threonine kinase 1	Homo sapiens	54-57
17322282-3	2007	Pretreatment with 50 microM of the PI3K inhibitor, LY-294002, or 20 microM PP2, a Src kinase inhibitor, significantly attenuated the increase in K(f), whereas 10 microM Akt inhibitor IV significantly augmented the increased K(f).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-60	thymoma viral proto-oncogene 1	Mus musculus	169-172
17412314-12	2007	Consequently, alpha2M-induced protein synthesis was inhibited upon treatment with the ERK1,2 inhibitor UO126 as well as by LY294002 and wortmannin, which inhibit PI3-kinase, and by rapamycin, which inhibits mammalian target of rapamycin (mTOR) downstream of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	alpha-2-macroglobulin	Homo sapiens	14-21
17372272-8	2007	Additionally, we describe that the phosphorylation of AKT and eIF4G, as well as the elevation of the Mst1 and RanBP2 protein levels, can be inhibited in vivo in transgenic animals by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	62-67
17372272-8	2007	Additionally, we describe that the phosphorylation of AKT and eIF4G, as well as the elevation of the Mst1 and RanBP2 protein levels, can be inhibited in vivo in transgenic animals by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	macrophage stimulating 1	Homo sapiens	101-105
17372272-8	2007	Additionally, we describe that the phosphorylation of AKT and eIF4G, as well as the elevation of the Mst1 and RanBP2 protein levels, can be inhibited in vivo in transgenic animals by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	RAN binding protein 2	Homo sapiens	110-116
17341442-8	2007	We found that PI3K inhibitor wortmannin or LY294002 blocked COX-2 expression induced by IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	60-65
17341442-8	2007	We found that PI3K inhibitor wortmannin or LY294002 blocked COX-2 expression induced by IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	insulin like growth factor 1	Homo sapiens	88-93
17307335-4	2007	Inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002 and by a dominant-negative PI3K mutant reduced the expression of Redd1 and activation of HIF-1alpha and Sp1 by CoCl(2) and HCD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	14-43
17449641-5	2007	LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), inhibited the induction of galectin-9 by poly IC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	26-55
17307335-4	2007	Inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002 and by a dominant-negative PI3K mutant reduced the expression of Redd1 and activation of HIF-1alpha and Sp1 by CoCl(2) and HCD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	DNA damage inducible transcript 4	Homo sapiens	128-133
17307335-4	2007	Inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002 and by a dominant-negative PI3K mutant reduced the expression of Redd1 and activation of HIF-1alpha and Sp1 by CoCl(2) and HCD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
17922342-8	2007	Inhibition of PKA by H-89 did not affect CSB-induced phosphorylation, whereas the PKB inhibitor LY-294002 enhanced it at Ser(1117).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-105	AKT serine/threonine kinase 1	Homo sapiens	82-85
17389653-4	2007	These same effects are not observed in Trk deficient PC12(nnr5) cells, but are re-established in PC12(nnr5) cells stably transfected with TrkA or TrkB, are partially blocked by inhibitors of tyrosine kinase (K-252a), mitogen-activated protein/mitogen-activated kinase (PD98059) and completely blocked by LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	304-312	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	138-142
17389653-4	2007	These same effects are not observed in Trk deficient PC12(nnr5) cells, but are re-established in PC12(nnr5) cells stably transfected with TrkA or TrkB, are partially blocked by inhibitors of tyrosine kinase (K-252a), mitogen-activated protein/mitogen-activated kinase (PD98059) and completely blocked by LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	304-312	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	146-150
17581202-14	2007	LTB(4) induced phosphorylation of ERK and Akt, downstream kinase of PI3K; LY294002 suppressed phosphorylation of both kinases while U0126 suppressed only the former.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	mitogen-activated protein kinase 1	Homo sapiens	34-37
17581202-14	2007	LTB(4) induced phosphorylation of ERK and Akt, downstream kinase of PI3K; LY294002 suppressed phosphorylation of both kinases while U0126 suppressed only the former.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	42-45
17395704-4	2007	DHEA stimulation of bovine aortic endothelial cells resulted in rapid and dose-dependent phosphorylation of Akt, which was blocked by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), the upstream kinase of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	AKT serine/threonine kinase 1	Bos taurus	108-111
17395704-4	2007	DHEA stimulation of bovine aortic endothelial cells resulted in rapid and dose-dependent phosphorylation of Akt, which was blocked by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), the upstream kinase of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	168-197
17395704-4	2007	DHEA stimulation of bovine aortic endothelial cells resulted in rapid and dose-dependent phosphorylation of Akt, which was blocked by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), the upstream kinase of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	AKT serine/threonine kinase 1	Bos taurus	229-232
17570654-5	2007	Blockade of the Akt signalling pathway by LY294002 abolished the elongation of tubes induced by FGF-2, whereas inhibition of the extracellular signal-regulated kinase (ERK) signalling pathway had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	AKT serine/threonine kinase 1	Rattus norvegicus	16-19
17570654-5	2007	Blockade of the Akt signalling pathway by LY294002 abolished the elongation of tubes induced by FGF-2, whereas inhibition of the extracellular signal-regulated kinase (ERK) signalling pathway had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	fibroblast growth factor 2	Rattus norvegicus	96-101
17449641-5	2007	LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), inhibited the induction of galectin-9 by poly IC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	galectin 9	Homo sapiens	91-101
17394554-7	2007	In parallel, it was found that the NA-induced increase in MCT2 protein was almost completely blocked by LY294002 (phosphoinositide 3-kinase inhibitor) as well as by rapamycin (mTOR inhibitor), while mitogen-activated protein kinase kinase and p38 MAPK inhibitors had much smaller effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	solute carrier family 16 member 7	Homo sapiens	58-62
17304506-7	2007	The PI3 kinase pathway inhibitors LY294002 and rapamycin inhibited the colony forming ability of all of the lines with the ErbB2 overexpressing lines having a higher sensitivity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	erb-b2 receptor tyrosine kinase 2	Homo sapiens	123-128
17482757-4	2007	Pre-treatment of LY294002 and Wortmannin, inhibitors of PI3K, inhibited the calyculin A-stimulated TNF-alpha mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	tumor necrosis factor	Mus musculus	99-108
17722999-3	2007	In this study, we tested the hypothesis that the combined inhibition of integrin alphanubeta3 by cRGD and PI3K/Akt by LY294002 would significantly enhance radiation-induced inhibition of angiogenesis by vascular endothelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	AKT serine/threonine kinase 1	Homo sapiens	111-114
17722999-7	2007	Treatment with LY294002 effectively inhibited radiation- and cRGD-induced Akt phosphorylation and up-regulation of COX2 and increased apoptosis of HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	74-77
17722999-7	2007	Treatment with LY294002 effectively inhibited radiation- and cRGD-induced Akt phosphorylation and up-regulation of COX2 and increased apoptosis of HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-119
17606477-6	2007	LY294002 and rapamycin each abrogated the IL-8-promoted phosphorylation of rS6 and attenuated the rate of AIPC cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
17539658-8	2007	EGCG also decreased the phosphorylation of Akt and extracellular signal-regulated kinase 1/2 that were demonstrated as selected downstream HRG-beta1-responsive kinases required for FAS expression using dominant-negative Akt, PI3K inhibitors (LY294002 and wortmannin), or MEK inhibitor (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	AKT serine/threonine kinase 1	Homo sapiens	43-46
17539658-8	2007	EGCG also decreased the phosphorylation of Akt and extracellular signal-regulated kinase 1/2 that were demonstrated as selected downstream HRG-beta1-responsive kinases required for FAS expression using dominant-negative Akt, PI3K inhibitors (LY294002 and wortmannin), or MEK inhibitor (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	mitogen-activated protein kinase 3	Homo sapiens	51-92
17539658-8	2007	EGCG also decreased the phosphorylation of Akt and extracellular signal-regulated kinase 1/2 that were demonstrated as selected downstream HRG-beta1-responsive kinases required for FAS expression using dominant-negative Akt, PI3K inhibitors (LY294002 and wortmannin), or MEK inhibitor (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	fatty acid synthase	Homo sapiens	181-184
17362920-5	2007	The effect of erythropoietin was mediated by the phosphatidylinositol 3-kinase (PI3K) signaling pathway since erythropoietin failed to rescue cells from MPP(+) insult in the presence of the PI3K inhibitor, LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	206-215	erythropoietin	Rattus norvegicus	14-28
17362920-6	2007	In addition, the downstream effector of PI3K, Akt, was activated by erythropoietin, and Akt activation was inhibited by LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-129	AKT serine/threonine kinase 1	Rattus norvegicus	46-49
17362920-6	2007	In addition, the downstream effector of PI3K, Akt, was activated by erythropoietin, and Akt activation was inhibited by LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-129	AKT serine/threonine kinase 1	Rattus norvegicus	88-91
17559672-10	2007	Inhibition of Akt phosphorylation with LY294002 increased apoptosis and blocked the effects of acid and leptin both alone and in combination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	14-17
17467686-6	2007	LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	kit ligand	Mus musculus	50-52
17467686-6	2007	LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	progastricsin (pepsinogen C)	Mus musculus	63-66
17467686-6	2007	LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	149-152
17467686-6	2007	LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	neuropeptide Y receptor Y6	Mus musculus	192-195
17467686-6	2007	LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	kit ligand	Mus musculus	244-246
17467686-6	2007	LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	progastricsin (pepsinogen C)	Mus musculus	257-260
17467686-6	2007	LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	275-278
17467686-6	2007	LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 1	Mus musculus	342-345
17467686-6	2007	LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	progastricsin (pepsinogen C)	Mus musculus	257-260
17467686-6	2007	LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	275-278
17450173-6	2007	KEY RESULTS: Either LY-294002 or geldanamycin reversed the increased activation of eNOS and Akt observed following SAO shock.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	nitric oxide synthase 3, endothelial cell	Mus musculus	83-87
17893997-11	2007	Pretreatment with the MEK1/2 inhibitor PD98059 as well as the PI3K inhibitor LY294002 resulted in inhibition of the cytokine-induced HIF-1alpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-143
17379415-8	2007	LY294002, a PI3K inhibitor, also abrogated BBS-stimulated phospho-Akt as well as its cell cycle targets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	gastrin releasing peptide	Homo sapiens	43-46
17379415-8	2007	LY294002, a PI3K inhibitor, also abrogated BBS-stimulated phospho-Akt as well as its cell cycle targets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	66-69
17379415-10	2007	BBS-mediated BrdU incorporation was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	gastrin releasing peptide	Homo sapiens	0-3
17434462-4	2007	ER stress-induced Akt activation was mediated through phosphatidylinositol 3-kinase (PI3K) because the PI3K inhibitors, LY294002 and wortmannin, inhibited Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	18-21
17434462-4	2007	ER stress-induced Akt activation was mediated through phosphatidylinositol 3-kinase (PI3K) because the PI3K inhibitors, LY294002 and wortmannin, inhibited Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	155-158
17638539-6	2007	In this paper, optimization of the Meso Scale Discovery (MSD) (Gaithersburg, MD) platform to quantify changes in phospho-AKT and phospho-glycogen synthase kinase-3beta in response to a PI3-kinase inhibitor, LY294002, is described, initially in vitro and then within xenografted solid tumors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	AKT serine/threonine kinase 1	Homo sapiens	121-124
17324123-6	2007	Another PI3K inhibitor, LY294002, and the tyrosine kinase inhibitor, Genistein, also inhibited insulin-induced activation of PDE3B and its co-immunoprecipitation with PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	phosphodiesterase 3B, cGMP-inhibited	Mus musculus	125-130
17329596-5	2007	An inhibitor of phosphoinositide-3-kinase (PIK3), LY 294002, significantly (P &lt; 0.05) reduced the IGF1-enhanced phosphorylation of AKT, and inhibitors of AKT (SH6) and MAPK3/1 (U0126) significantly (P &lt; 0.05) decreased the synthesis and retention of HA stimulated by concomitant exposure of OCCs to both FSH and IGF1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	insulin like growth factor 1	Sus scrofa	101-105
17329596-5	2007	An inhibitor of phosphoinositide-3-kinase (PIK3), LY 294002, significantly (P &lt; 0.05) reduced the IGF1-enhanced phosphorylation of AKT, and inhibitors of AKT (SH6) and MAPK3/1 (U0126) significantly (P &lt; 0.05) decreased the synthesis and retention of HA stimulated by concomitant exposure of OCCs to both FSH and IGF1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	AKT serine/threonine kinase 1	Sus scrofa	134-137
17329596-5	2007	An inhibitor of phosphoinositide-3-kinase (PIK3), LY 294002, significantly (P &lt; 0.05) reduced the IGF1-enhanced phosphorylation of AKT, and inhibitors of AKT (SH6) and MAPK3/1 (U0126) significantly (P &lt; 0.05) decreased the synthesis and retention of HA stimulated by concomitant exposure of OCCs to both FSH and IGF1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	AKT serine/threonine kinase 1	Sus scrofa	157-160
17329596-5	2007	An inhibitor of phosphoinositide-3-kinase (PIK3), LY 294002, significantly (P &lt; 0.05) reduced the IGF1-enhanced phosphorylation of AKT, and inhibitors of AKT (SH6) and MAPK3/1 (U0126) significantly (P &lt; 0.05) decreased the synthesis and retention of HA stimulated by concomitant exposure of OCCs to both FSH and IGF1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	mitogen-activated protein kinase 3	Sus scrofa	171-176
17329596-5	2007	An inhibitor of phosphoinositide-3-kinase (PIK3), LY 294002, significantly (P &lt; 0.05) reduced the IGF1-enhanced phosphorylation of AKT, and inhibitors of AKT (SH6) and MAPK3/1 (U0126) significantly (P &lt; 0.05) decreased the synthesis and retention of HA stimulated by concomitant exposure of OCCs to both FSH and IGF1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	insulin like growth factor 1	Sus scrofa	318-322
17388918-4	2007	METHODS: Using a panel of pharmacological inhibitors (BAY 43-9006, PD98059, U0126, wortmannin, LY294002) we inhibited the MAPK and AKT signalling pathways at different levels and evaluated the effects on growth, survival and invasion of melanoma cells in monolayer and organotypic skin culture.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	131-134
17450173-6	2007	KEY RESULTS: Either LY-294002 or geldanamycin reversed the increased activation of eNOS and Akt observed following SAO shock.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	thymoma viral proto-oncogene 1	Mus musculus	92-95
17317782-6	2007	The stimulatory effect of IGF-I on GK promoter activity was abrogated by wortmannin and LY294002, specific inhibitors of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	insulin like growth factor 1	Homo sapiens	26-31
17303382-10	2007	When tube-forming HUVECs were treated with U0126 or LY294002 during normoxia, the two inhibitors were able to induce apoptosis and activation of p38 and caspase-3 in a relatively short time.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	mitogen-activated protein kinase 1	Homo sapiens	145-148
17303382-10	2007	When tube-forming HUVECs were treated with U0126 or LY294002 during normoxia, the two inhibitors were able to induce apoptosis and activation of p38 and caspase-3 in a relatively short time.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	caspase 3	Homo sapiens	153-162
17303382-12	2007	In contrast, LY294002 was able to inhibit Akt activation, but had very little effect on ERK1/2 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	42-45
17545550-10	2007	Pemetrexed induced an epidermal growth factor receptor-mediated activation of the phosphatidylinositol 3-kinase/AKT pathway, which was inhibited by erlotinib and a specific phosphatidylinositol 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	epidermal growth factor receptor	Homo sapiens	22-54
17545550-10	2007	Pemetrexed induced an epidermal growth factor receptor-mediated activation of the phosphatidylinositol 3-kinase/AKT pathway, which was inhibited by erlotinib and a specific phosphatidylinositol 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	AKT serine/threonine kinase 1	Homo sapiens	112-115
17300916-6	2007	Activation of both, Rac1 and RhoA, seen at low and high expression levels of RGS3L, respectively, was sensitive to pertussis toxin and the PI3K inhibitor LY294002 and mediated by Gbetagamma-dimers.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	Rac family small GTPase 1	Homo sapiens	20-24
17300916-6	2007	Activation of both, Rac1 and RhoA, seen at low and high expression levels of RGS3L, respectively, was sensitive to pertussis toxin and the PI3K inhibitor LY294002 and mediated by Gbetagamma-dimers.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	ras homolog family member A	Homo sapiens	29-33
17317782-6	2007	The stimulatory effect of IGF-I on GK promoter activity was abrogated by wortmannin and LY294002, specific inhibitors of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	glucokinase	Homo sapiens	35-37
17459097-9	2007	Furthermore, we also found that PP1 and LY294002, but not PD98059 inhibit the S5a promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Homo sapiens	78-81
17341418-11	2007	LY294002, a phosphoinositide-3 kinase (PI3K)/AKT inhibitor, and Trolox, an antioxidant, suppressed indomethacin-induced cytotoxicity and caspase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	45-48
17317726-5	2007	PI 3-kinase (PI3K) inhibitors (LY294002 or wortmannin), Akt inhibitors, or Akt1 siRNA blocked adhesion stimulated by 15 mmHg pressure in SW620 or primary human malignant colonocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	0-11
17317726-7	2007	PI3K inhibitor (LY294002) prevented pressure-stimulated Akt Ser473 and FAK Tyr397, but not FAK576 or Src416 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	56-59
17317726-7	2007	PI3K inhibitor (LY294002) prevented pressure-stimulated Akt Ser473 and FAK Tyr397, but not FAK576 or Src416 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	protein tyrosine kinase 2	Homo sapiens	71-74
17299794-4	2007	We initially observed that IL-1beta-induced ICAM-1 promoter activity was attenuated by the inhibitors of Src (PP1), PDGFR (AG1296), PI3-K (LY294002 and wortmannin), and Akt (SH-5), revealed by reporter gene assay, Western blotting, and RT-PCR analyses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	interleukin 1 beta	Homo sapiens	27-35
17545278-5	2007	The inhibition of phosphatidylinositol 3-kinase (PI3K) signaling by LY294002, a chemical inhibitor of PI3K, abolished the maintenance of maximal suppressive potency by IL-2, yet had no effect on the up-regulation of FOXP3, CD25, CTLA-4 and GITR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	18-47
17404186-10	2007	The inhibitory effect of Ang II on hSR-BI/CLA-1 promoter activity was abrogated by wortmannin and LY294002, specific inhibitors of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	angiotensinogen	Homo sapiens	25-31
17404186-10	2007	The inhibitory effect of Ang II on hSR-BI/CLA-1 promoter activity was abrogated by wortmannin and LY294002, specific inhibitors of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	scavenger receptor class B member 1	Homo sapiens	35-41
17404186-10	2007	The inhibitory effect of Ang II on hSR-BI/CLA-1 promoter activity was abrogated by wortmannin and LY294002, specific inhibitors of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	scavenger receptor class B member 1	Homo sapiens	42-47
17545278-5	2007	The inhibition of phosphatidylinositol 3-kinase (PI3K) signaling by LY294002, a chemical inhibitor of PI3K, abolished the maintenance of maximal suppressive potency by IL-2, yet had no effect on the up-regulation of FOXP3, CD25, CTLA-4 and GITR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	interleukin 2	Homo sapiens	168-172
17442787-9	2007	Inhibition of PI3-K signaling with wortmannin and LY294002 but not its inactive analogue rapidly and markedly decreased the P(o) of ENaC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	132-136
17299794-10	2007	Up-regulation of ICAM-1 enhanced the adhesion of neutrophils onto A549 cell monolayer exposed to IL-1beta, which was inhibited by PP1, AG1296, LY294002, wortmannin, and helenalin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	intercellular adhesion molecule 1	Homo sapiens	17-23
17299794-10	2007	Up-regulation of ICAM-1 enhanced the adhesion of neutrophils onto A549 cell monolayer exposed to IL-1beta, which was inhibited by PP1, AG1296, LY294002, wortmannin, and helenalin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	interleukin 1 beta	Homo sapiens	97-105
17299794-4	2007	We initially observed that IL-1beta-induced ICAM-1 promoter activity was attenuated by the inhibitors of Src (PP1), PDGFR (AG1296), PI3-K (LY294002 and wortmannin), and Akt (SH-5), revealed by reporter gene assay, Western blotting, and RT-PCR analyses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	intercellular adhesion molecule 1	Homo sapiens	44-50
17299794-9	2007	Association of p300 and histone-H4 to ICAM-1 promoter was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	E1A binding protein p300	Homo sapiens	15-19
17299794-9	2007	Association of p300 and histone-H4 to ICAM-1 promoter was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	H4 clustered histone 9	Homo sapiens	24-34
17299794-9	2007	Association of p300 and histone-H4 to ICAM-1 promoter was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	intercellular adhesion molecule 1	Homo sapiens	38-44
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	tumor necrosis factor	Homo sapiens	0-9
17556532-7	2007	Using a specific phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, we also found that PI3K was involved in the pathway by which IGF-I activated NF-kappaB and increased FLIP expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	17-46
17556532-7	2007	Using a specific phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, we also found that PI3K was involved in the pathway by which IGF-I activated NF-kappaB and increased FLIP expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	insulin-like growth factor 1	Rattus norvegicus	136-141
17556532-8	2007	When treated with IGF-I and LY294002, decreased NF-kappaB DNA binding activity and increased expression of IkappaBalpha protein were detected in cultured thyroid cells, which further confirmed that NF-kappaB was under the control of the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	NFKB inhibitor alpha	Rattus norvegicus	107-119
17513782-9	2007	Specifically, heart infarct size/area at risk was increased by 98% in wortmannin and 101% in LY294002-treated TLR4(-/-) mice, when compared with control TLR4(-/-) mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	toll-like receptor 4	Mus musculus	110-114
17513782-9	2007	Specifically, heart infarct size/area at risk was increased by 98% in wortmannin and 101% in LY294002-treated TLR4(-/-) mice, when compared with control TLR4(-/-) mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	toll-like receptor 4	Mus musculus	153-157
17371807-6	2007	The stimulation of Akt phosphorylation was inhibited in a concentration-dependent manner by the PI3K inhibitor, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-160	AKT serine/threonine kinase 1	Homo sapiens	19-22
17371807-6	2007	The stimulation of Akt phosphorylation was inhibited in a concentration-dependent manner by the PI3K inhibitor, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	AKT serine/threonine kinase 1	Homo sapiens	19-22
17136479-5	2007	N-tosyl phenylalanyl chloromethyl ketone (TPCK), wortmannin and Ly294002 inhibited IL-1beta-induced NF-kappaB activation in both systems indicating involvement of the PI3K axis in this response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	interleukin 1 beta	Homo sapiens	83-91
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	interleukin 1 beta	Homo sapiens	32-40
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	interleukin 6	Homo sapiens	42-46
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	AKT serine/threonine kinase 1	Homo sapiens	177-180
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	interleukin 1 beta	Homo sapiens	206-214
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	interleukin 6	Homo sapiens	216-220
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
17314215-11	2007	TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	tumor necrosis factor	Homo sapiens	252-261
17400198-8	2007	In addition, it appears that these neuroprotective effects are linked to activation of the PI-3K pathways, because the PI-3K inhibitor LY294002 blocks the neuroprotective effects of S100B.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	S100 calcium binding protein B	Rattus norvegicus	182-187
17939398-5	2007	Phosphorylation of AKT was inhibited by LY294002 and then examined by Western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	19-22
17939398-9	2007	Furthermore treatment with PI3K/AKT inhibitor LY294002 also resulted in decrease of TF expression in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	32-35
17939398-9	2007	Furthermore treatment with PI3K/AKT inhibitor LY294002 also resulted in decrease of TF expression in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	coagulation factor III, tissue factor	Homo sapiens	84-86
17289850-5	2007	Inhibition of the phosphatidylinositol 3-kinase signaling pathway using LY294002, or the downstream signaling intermediate mammalian target of rapamycin using rapamycin, markedly reduced IGFBP-2 in conditioned medium to approximately 25% of untreated levels (P &lt; 0.001); there was no effect of inhibition of p38 MAPK, and an inhibitor of p44/42 MAPK activation, PD98059, caused only a slight reduction in extracellular IGFBP-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	insulin like growth factor binding protein 2	Homo sapiens	187-194
17382293-6	2007	The IGF-1-induced increase in MSC migration in response to SDF-1 was attenuated by PI3 kinase inhibitor (LY294002 and wortmannin) but not by mitogen-activated protein/ERK kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	insulin-like growth factor 1	Rattus norvegicus	4-9
17382293-6	2007	The IGF-1-induced increase in MSC migration in response to SDF-1 was attenuated by PI3 kinase inhibitor (LY294002 and wortmannin) but not by mitogen-activated protein/ERK kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	C-X-C motif chemokine ligand 12	Rattus norvegicus	59-64
17382293-6	2007	The IGF-1-induced increase in MSC migration in response to SDF-1 was attenuated by PI3 kinase inhibitor (LY294002 and wortmannin) but not by mitogen-activated protein/ERK kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	WAP four-disulfide core domain 15B	Rattus norvegicus	83-86
17183064-7	2007	Inhibitors of ERK (PD98059) or Akt (LY294002), but not p38 MAPK, resulted in significantly decreased cell viability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	31-34
17594810-10	2007	In addition, 100 and 200 micromol/L DHEA treatments for 24 hours markedly inhibited phosphorylations of Akt (Thr308 and Ser473) in HepG2 cells, and these effects were enhanced by exposing them to LY294002 and stopped by exposing them to HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	AKT serine/threonine kinase 1	Homo sapiens	104-107
17594810-10	2007	In addition, 100 and 200 micromol/L DHEA treatments for 24 hours markedly inhibited phosphorylations of Akt (Thr308 and Ser473) in HepG2 cells, and these effects were enhanced by exposing them to LY294002 and stopped by exposing them to HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	hepatocyte growth factor	Homo sapiens	237-240
17473185-9	2007	Blocking extracellular signal-regulated kinase 1/2 (ERK 1/2) and phosphoinositide-3-kinase by PD98059 and LY294002, respectively, abolished 16 E6- and E7-induced HIF-1 alpha and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	mitogen-activated protein kinase 1	Homo sapiens	9-50
17473185-9	2007	Blocking extracellular signal-regulated kinase 1/2 (ERK 1/2) and phosphoinositide-3-kinase by PD98059 and LY294002, respectively, abolished 16 E6- and E7-induced HIF-1 alpha and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	mitogen-activated protein kinase 3	Homo sapiens	52-59
17473185-9	2007	Blocking extracellular signal-regulated kinase 1/2 (ERK 1/2) and phosphoinositide-3-kinase by PD98059 and LY294002, respectively, abolished 16 E6- and E7-induced HIF-1 alpha and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	hypoxia inducible factor 1 subunit alpha	Homo sapiens	162-173
17473185-9	2007	Blocking extracellular signal-regulated kinase 1/2 (ERK 1/2) and phosphoinositide-3-kinase by PD98059 and LY294002, respectively, abolished 16 E6- and E7-induced HIF-1 alpha and VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	vascular endothelial growth factor A	Homo sapiens	178-182
17394208-8	2007	We found that SU5402 and LY294002 significantly reduced Elf5 expression, whereas U0126 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	E74-like factor 5	Mus musculus	56-60
17394208-9	2007	LY294002 also reduced Elf5 expression in cultures of purified epithelium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	E74-like factor 5	Mus musculus	22-26
17289850-8	2007	Basal, IGF-, or estradiol-stimulated IGFBP-2 was abrogated by LY294002 and rapamycin and an inhibitor of IGFR1 tyrosine kinase activity, AG1024.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	insulin like growth factor binding protein 2	Homo sapiens	37-44
17418144-4	2007	Our results suggest that stability of unliganded VDR is LY294002- and PD98059-dependent, and that ligation of VDR leads to its increased translation and nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	vitamin D receptor	Homo sapiens	49-52
17521372-3	2007	LY294002, a phosphoinositide 3-kinase inhibitor, significantly inhibited VEGF-A-induced chemotaxis and capillary-like morphogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	vascular endothelial growth factor A	Homo sapiens	73-79
17186497-7	2007	The PI 3 kinase inhibitor Ly294002 and expression of tumor suppressor protein PTEN inhibited Akt kinase activity, resulting in the attenuation of FoxO1 phosphorylation and preventing the downregulating effect of H(2)O(2) on catalase protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Homo sapiens	93-96
17186497-7	2007	The PI 3 kinase inhibitor Ly294002 and expression of tumor suppressor protein PTEN inhibited Akt kinase activity, resulting in the attenuation of FoxO1 phosphorylation and preventing the downregulating effect of H(2)O(2) on catalase protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	forkhead box O1	Homo sapiens	146-151
17186497-7	2007	The PI 3 kinase inhibitor Ly294002 and expression of tumor suppressor protein PTEN inhibited Akt kinase activity, resulting in the attenuation of FoxO1 phosphorylation and preventing the downregulating effect of H(2)O(2) on catalase protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	catalase	Homo sapiens	224-232
17390018-3	2007	The PI 3-K inhibitors wortmannin and LY294002 markedly suppressed phosphorylation of Akt and accelerated TRAIL-mediated apoptosis in OSCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	85-88
17390018-3	2007	The PI 3-K inhibitors wortmannin and LY294002 markedly suppressed phosphorylation of Akt and accelerated TRAIL-mediated apoptosis in OSCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	TNF superfamily member 10	Homo sapiens	105-110
17633444-9	2007	VEGFproduction was suppressed when CD147 expression was inhibited by LY294002 or HAb18G mAb.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	basigin (Ok blood group)	Homo sapiens	35-40
17171644-7	2007	The specific chemical inhibitors LY294002 (PI3K), PP2 (Src), U0126 (MAPK-ERK kinase (MEK)/ERK), and SP600125 (JNK) effectively suppressed cell fusion, although SB203580 (p38) did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	Rous sarcoma oncogene	Mus musculus	55-58
17171644-7	2007	The specific chemical inhibitors LY294002 (PI3K), PP2 (Src), U0126 (MAPK-ERK kinase (MEK)/ERK), and SP600125 (JNK) effectively suppressed cell fusion, although SB203580 (p38) did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	mitogen-activated protein kinase 1	Mus musculus	73-76
17171644-7	2007	The specific chemical inhibitors LY294002 (PI3K), PP2 (Src), U0126 (MAPK-ERK kinase (MEK)/ERK), and SP600125 (JNK) effectively suppressed cell fusion, although SB203580 (p38) did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	mitogen-activated protein kinase 1	Mus musculus	90-93
17171644-7	2007	The specific chemical inhibitors LY294002 (PI3K), PP2 (Src), U0126 (MAPK-ERK kinase (MEK)/ERK), and SP600125 (JNK) effectively suppressed cell fusion, although SB203580 (p38) did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	mitogen-activated protein kinase 8	Mus musculus	110-113
17007924-0	2007	Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	32-35
17007924-0	2007	Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	mechanistic target of rapamycin kinase	Homo sapiens	36-40
17007924-4	2007	Blockade of Akt signaling by the PI3K inhibitor LY294002 (1-20 microM, 48 h) also resulted in the growth inhibition and G0/G1 cell cycle arrest of HTLV-1-infected cells, with IC50 ranging from 5 to 20muM, and it caused de-phosphorylation of p70S6K and 4E-BP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	12-15
17007924-6	2007	Moreover, both LY294002 and rapamycin down-regulated the levels of c-Myc and cyclin D1 proteins in these cells, and their combination further decreased levels of these cell cycle-regulating proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	67-72
17007924-6	2007	Moreover, both LY294002 and rapamycin down-regulated the levels of c-Myc and cyclin D1 proteins in these cells, and their combination further decreased levels of these cell cycle-regulating proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cyclin D1	Homo sapiens	77-86
17255101-6	2007	On the other hand, LY294002 and rapamycin abolished PAK1 phosphorylation and enhanced HCV abundance, suggesting that the mammalian target of rapamycin (mTOR) is involved in PAK1 regulation of HCV.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	p21 (RAC1) activated kinase 1	Homo sapiens	52-56
17464197-5	2007	In addition, hydroquinone and inhibitors (wortmannin and LY294002) of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway had very similar inhibitory effects on LPS-induced and CD29-mediated macrophage responses, including the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	111-114
17464197-5	2007	In addition, hydroquinone and inhibitors (wortmannin and LY294002) of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway had very similar inhibitory effects on LPS-induced and CD29-mediated macrophage responses, including the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	integrin subunit beta 1	Homo sapiens	178-182
17464197-5	2007	In addition, hydroquinone and inhibitors (wortmannin and LY294002) of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway had very similar inhibitory effects on LPS-induced and CD29-mediated macrophage responses, including the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	247-250
17255101-6	2007	On the other hand, LY294002 and rapamycin abolished PAK1 phosphorylation and enhanced HCV abundance, suggesting that the mammalian target of rapamycin (mTOR) is involved in PAK1 regulation of HCV.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	mechanistic target of rapamycin kinase	Homo sapiens	121-150
17255101-6	2007	On the other hand, LY294002 and rapamycin abolished PAK1 phosphorylation and enhanced HCV abundance, suggesting that the mammalian target of rapamycin (mTOR) is involved in PAK1 regulation of HCV.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	mechanistic target of rapamycin kinase	Homo sapiens	152-156
17255101-6	2007	On the other hand, LY294002 and rapamycin abolished PAK1 phosphorylation and enhanced HCV abundance, suggesting that the mammalian target of rapamycin (mTOR) is involved in PAK1 regulation of HCV.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	p21 (RAC1) activated kinase 1	Homo sapiens	173-177
17382199-2	2007	Using the PI3K inhibitor LY294002 and PTEN knockout mouse embryonic fibroblasts, we show that phosphorylation of Akt by superoxide requires the production of PIP3 and that the target for the induction of Akt phosphorylation by O2.- is the phosphatase PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	thymoma viral proto-oncogene 1	Mus musculus	113-116
17349623-6	2007	Pretreatment with phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 completely blocked GRP-initiated Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	18-47
17349623-6	2007	Pretreatment with phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 completely blocked GRP-initiated Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	gastrin releasing peptide	Homo sapiens	93-96
17382199-2	2007	Using the PI3K inhibitor LY294002 and PTEN knockout mouse embryonic fibroblasts, we show that phosphorylation of Akt by superoxide requires the production of PIP3 and that the target for the induction of Akt phosphorylation by O2.- is the phosphatase PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	thymoma viral proto-oncogene 1	Mus musculus	204-207
17349623-6	2007	Pretreatment with phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 completely blocked GRP-initiated Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	107-110
17307160-4	2007	Treatment of A549 cells with LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, a PI3K inhibitor), an Akt inhibitor, and the dominant negative mutant of Akt (Akt DN) inhibited TGF-beta1-induced HO-1 expression and HO-1-luciferase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-38	AKT serine/threonine kinase 1	Homo sapiens	112-115
17362927-7	2007	Inhibition of PI3K with LY294002 caused a 12-fold increase in endocan transcription suggesting a repressive function of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	endothelial cell specific molecule 1	Homo sapiens	62-69
17307160-8	2007	The TGF-beta1-mediated increases in IKKalpha/beta phosphorylation, p65 Ser536 phosphorylation, and kappaB-luciferase activity were inhibited by LY 294002, an Akt inhibitor, and Akt DN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-153	transforming growth factor beta 1	Homo sapiens	4-13
17307160-4	2007	Treatment of A549 cells with LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, a PI3K inhibitor), an Akt inhibitor, and the dominant negative mutant of Akt (Akt DN) inhibited TGF-beta1-induced HO-1 expression and HO-1-luciferase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-88	transforming growth factor beta 1	Homo sapiens	186-195
17307160-8	2007	The TGF-beta1-mediated increases in IKKalpha/beta phosphorylation, p65 Ser536 phosphorylation, and kappaB-luciferase activity were inhibited by LY 294002, an Akt inhibitor, and Akt DN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-153	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	36-44
17307160-4	2007	Treatment of A549 cells with LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, a PI3K inhibitor), an Akt inhibitor, and the dominant negative mutant of Akt (Akt DN) inhibited TGF-beta1-induced HO-1 expression and HO-1-luciferase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-88	heme oxygenase 1	Homo sapiens	204-208
17307160-8	2007	The TGF-beta1-mediated increases in IKKalpha/beta phosphorylation, p65 Ser536 phosphorylation, and kappaB-luciferase activity were inhibited by LY 294002, an Akt inhibitor, and Akt DN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-153	RELA proto-oncogene, NF-kB subunit	Homo sapiens	67-70
17307160-8	2007	The TGF-beta1-mediated increases in IKKalpha/beta phosphorylation, p65 Ser536 phosphorylation, and kappaB-luciferase activity were inhibited by LY 294002, an Akt inhibitor, and Akt DN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-153	AKT serine/threonine kinase 1	Homo sapiens	158-161
17307160-5	2007	Stimulation of cells with TGF-beta1 caused an increase in Akt phosphorylation in a time-dependent manner, which was inhibited by wortmannin and LY 294002 (PI3K inhibitors).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-153	transforming growth factor beta 1	Homo sapiens	26-35
17307160-8	2007	The TGF-beta1-mediated increases in IKKalpha/beta phosphorylation, p65 Ser536 phosphorylation, and kappaB-luciferase activity were inhibited by LY 294002, an Akt inhibitor, and Akt DN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-153	AKT serine/threonine kinase 1	Homo sapiens	177-180
17307160-5	2007	Stimulation of cells with TGF-beta1 caused an increase in Akt phosphorylation in a time-dependent manner, which was inhibited by wortmannin and LY 294002 (PI3K inhibitors).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-153	AKT serine/threonine kinase 1	Homo sapiens	58-61
17367785-6	2007	However, LPS-induced expression of IDO was inhibited by LY294002 and SP600125 but not by JAK inhibitor I, SB203580, or U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	toll-like receptor 4	Mus musculus	9-12
17229588-6	2007	In addition, induction of IAP2 and phosphorylated Akt proteins by COF and 2,4-DDE were simultaneously abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	baculoviral IAP repeat containing 2	Homo sapiens	26-30
17367785-6	2007	However, LPS-induced expression of IDO was inhibited by LY294002 and SP600125 but not by JAK inhibitor I, SB203580, or U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	indoleamine 2,3-dioxygenase 1	Mus musculus	35-38
17170237-10	2007	In contrast, the effects of insulin on NO production were blocked by the phosphoinositide 3-kinase inhibitors wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-134	insulin	Homo sapiens	28-35
17172275-5	2007	Inhibition of PI3K with wortmannin or LY-294002 enhanced PAI-1 expression induced by these extracellular stimuli.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-47	serpin family E member 1	Homo sapiens	57-62
17209135-7	2007	Inhibition of phosphatidylinositol 3-kinase and Akt phosphorylation by LY-294002 abolished TGF-beta-induced increases in elastin hnRNA and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-80	AKT serine/threonine kinase 1	Homo sapiens	48-51
17209135-7	2007	Inhibition of phosphatidylinositol 3-kinase and Akt phosphorylation by LY-294002 abolished TGF-beta-induced increases in elastin hnRNA and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-80	transforming growth factor beta 1	Homo sapiens	91-99
17190911-4	2007	Furthermore, aldosterone activated PI3-K and phosphorylation of the most downstream element, Akt, was blocked by the specific PI3-K inhibitor LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-151	v-akt murine thymoma viral oncogene homolog 1 S homeolog	Xenopus laevis	93-96
17209135-7	2007	Inhibition of phosphatidylinositol 3-kinase and Akt phosphorylation by LY-294002 abolished TGF-beta-induced increases in elastin hnRNA and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-80	elastin	Homo sapiens	121-128
17409395-11	2007	The changes in these EMT characteristics brought about by PRL-3 can be abrogated by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002, implying that PRL-3 acts upstream of PI3K and could play an initiating role to trigger the EMT switch during cancer metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	submaxillary gland androgen regulated protein 3B	Homo sapiens	58-63
17409395-11	2007	The changes in these EMT characteristics brought about by PRL-3 can be abrogated by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002, implying that PRL-3 acts upstream of PI3K and could play an initiating role to trigger the EMT switch during cancer metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	88-113
17321171-5	2007	In contrast, in mES cells treated with LY294002, the activities of Cdk2 and E2F were significantly decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	cyclin-dependent kinase 2	Mus musculus	67-71
17409395-11	2007	The changes in these EMT characteristics brought about by PRL-3 can be abrogated by the phosphoinositide 3-kinase (PI3K) inhibitor LY294002, implying that PRL-3 acts upstream of PI3K and could play an initiating role to trigger the EMT switch during cancer metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	submaxillary gland androgen regulated protein 3B	Homo sapiens	155-160
16912864-9	2007	The proliferative and anti-apoptotic effects of leptin were abolished by inhibition of JAK2 with AG490, phosphatidylinositol 3"-kinase (PI3 kinase) with LY294002 and c-Jun NH(2)-terminal kinase (JNK) with SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	leptin	Homo sapiens	48-54
17408630-7	2007	Constitutively active FoxO1 inhibits proliferation via cell cycle arrest at the G1 phase, whereas dominant-negative FoxO1 enhances proliferation of HSCs even in the presence of the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	196-204	forkhead box O1	Mus musculus	116-121
17332930-9	2007	Downregulation of AKT by inhibitors of PI3K (Wortmannin and LY294002) and AKT, or by dominant negative AKT increased curcumin-induced apoptosis, whereas transfection of constitutively active AKT attenuated this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	18-21
17321472-8	2007	Moreover, the LPS-induced NO production and NF-kappaB activation was inhibited by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase/Akt pathway, in RAW 264.7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	thymoma viral proto-oncogene 1	Mus musculus	146-149
17267947-6	2007	Wortmannin, LY294002, and PD98059, used as inhibitors of upstream kinases (the PI3-kinase/Akt/PDK1 or MEK-1 pathway) in cultures, markedly attenuated AA release and the expression of phosphorylated forms of endothelial cPLA(2), PKCalpha, and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	90-93
17624239-10	2007	The PI3-kinase inhibitors, wortmannin and LY294002 counteracted the IL-3-induced expression of CD203c, whereas MEK- and PKC inhibitors showed no effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	interleukin 3	Homo sapiens	68-72
17624239-10	2007	The PI3-kinase inhibitors, wortmannin and LY294002 counteracted the IL-3-induced expression of CD203c, whereas MEK- and PKC inhibitors showed no effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	95-101
17267947-6	2007	Wortmannin, LY294002, and PD98059, used as inhibitors of upstream kinases (the PI3-kinase/Akt/PDK1 or MEK-1 pathway) in cultures, markedly attenuated AA release and the expression of phosphorylated forms of endothelial cPLA(2), PKCalpha, and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	pyruvate dehydrogenase kinase 1	Rattus norvegicus	94-98
17267947-6	2007	Wortmannin, LY294002, and PD98059, used as inhibitors of upstream kinases (the PI3-kinase/Akt/PDK1 or MEK-1 pathway) in cultures, markedly attenuated AA release and the expression of phosphorylated forms of endothelial cPLA(2), PKCalpha, and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	mitogen activated protein kinase kinase 1	Rattus norvegicus	102-107
17267947-6	2007	Wortmannin, LY294002, and PD98059, used as inhibitors of upstream kinases (the PI3-kinase/Akt/PDK1 or MEK-1 pathway) in cultures, markedly attenuated AA release and the expression of phosphorylated forms of endothelial cPLA(2), PKCalpha, and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	phospholipase A2 group IVA	Rattus norvegicus	219-226
17267947-6	2007	Wortmannin, LY294002, and PD98059, used as inhibitors of upstream kinases (the PI3-kinase/Akt/PDK1 or MEK-1 pathway) in cultures, markedly attenuated AA release and the expression of phosphorylated forms of endothelial cPLA(2), PKCalpha, and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	protein kinase C, alpha	Rattus norvegicus	228-236
17267947-6	2007	Wortmannin, LY294002, and PD98059, used as inhibitors of upstream kinases (the PI3-kinase/Akt/PDK1 or MEK-1 pathway) in cultures, markedly attenuated AA release and the expression of phosphorylated forms of endothelial cPLA(2), PKCalpha, and ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	mitogen activated protein kinase 3	Rattus norvegicus	242-248
17342093-7	2007	Inhibition of phosphoinositidyl-3 (PI3-K)/Akt pathway with either the small molecule inhibitor LY294002 or dominant-negative Akt resulted in reversal of anoikis resistance induced by HMGA1 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	42-45
17443435-7	2007	Furthermore, puerarin-stimulated osteoblastic growth, Akt activation and redistribution were significantly blocked by the specific PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
17342093-7	2007	Inhibition of phosphoinositidyl-3 (PI3-K)/Akt pathway with either the small molecule inhibitor LY294002 or dominant-negative Akt resulted in reversal of anoikis resistance induced by HMGA1 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	high mobility group AT-hook 1	Homo sapiens	183-188
17215071-5	2007	The phosphorylation of Akt induced by FGF-2 was markedly attenuated by wortmannin and LY294002, inhibitors of phosphatidylinositol 3-kinase (PI3-kinase) in osteoblast-like MC3T3-E1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	thymoma viral proto-oncogene 1	Mus musculus	23-26
17196174-4	2007	Inhibition of the PI3K pathway with LY294002 significantly reduced both PGD2-induced cell migration and cytokine (interleukin-4, interleukin-5 and interleukin-13) production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	interleukin 4	Homo sapiens	114-127
17196174-4	2007	Inhibition of the PI3K pathway with LY294002 significantly reduced both PGD2-induced cell migration and cytokine (interleukin-4, interleukin-5 and interleukin-13) production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	interleukin 5	Homo sapiens	129-142
17196174-4	2007	Inhibition of the PI3K pathway with LY294002 significantly reduced both PGD2-induced cell migration and cytokine (interleukin-4, interleukin-5 and interleukin-13) production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	interleukin 13	Homo sapiens	147-161
17196174-7	2007	The promotion of NFAT nuclear location by PI3K activation may be mediated by negative regulation of glycogen synthase kinase-3beta (GSK3beta), since the PGD2-stimulated increase in phospho-GSK3beta was down-regulated by LY294002, and inhibition of GSK3beta by SB216763 enhanced PGD2-induced Th2 cytokine production and reversed the inhibitory effect of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	glycogen synthase kinase 3 beta	Homo sapiens	100-130
17196174-7	2007	The promotion of NFAT nuclear location by PI3K activation may be mediated by negative regulation of glycogen synthase kinase-3beta (GSK3beta), since the PGD2-stimulated increase in phospho-GSK3beta was down-regulated by LY294002, and inhibition of GSK3beta by SB216763 enhanced PGD2-induced Th2 cytokine production and reversed the inhibitory effect of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	glycogen synthase kinase 3 beta	Homo sapiens	132-140
17196174-7	2007	The promotion of NFAT nuclear location by PI3K activation may be mediated by negative regulation of glycogen synthase kinase-3beta (GSK3beta), since the PGD2-stimulated increase in phospho-GSK3beta was down-regulated by LY294002, and inhibition of GSK3beta by SB216763 enhanced PGD2-induced Th2 cytokine production and reversed the inhibitory effect of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	353-361	glycogen synthase kinase 3 beta	Homo sapiens	100-130
17196174-7	2007	The promotion of NFAT nuclear location by PI3K activation may be mediated by negative regulation of glycogen synthase kinase-3beta (GSK3beta), since the PGD2-stimulated increase in phospho-GSK3beta was down-regulated by LY294002, and inhibition of GSK3beta by SB216763 enhanced PGD2-induced Th2 cytokine production and reversed the inhibitory effect of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	353-361	glycogen synthase kinase 3 beta	Homo sapiens	132-140
17215071-5	2007	The phosphorylation of Akt induced by FGF-2 was markedly attenuated by wortmannin and LY294002, inhibitors of phosphatidylinositol 3-kinase (PI3-kinase) in osteoblast-like MC3T3-E1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	fibroblast growth factor 2	Mus musculus	38-43
17215071-6	2007	Both wortmannin and LY294002 enhanced the FGF-2-induced VEGF release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	fibroblast growth factor 2	Mus musculus	42-47
17215071-6	2007	Both wortmannin and LY294002 enhanced the FGF-2-induced VEGF release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	vascular endothelial growth factor A	Mus musculus	56-60
17250809-4	2007	Treatment of cardiomyocytes with inhibitors of phosphatidylinositol 3-kinase (LY294002) or Akt (Akti-1/2) abolished the protective effect of erythropoietin, whereas treatment with MAPK kinase (MEK1) inhibitor U0126 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	erythropoietin	Rattus norvegicus	141-155
17461449-6	2007	Moreover, treatment with MEK1/2 inhibitor (U0126) or PI3K inhibitor (LY294002) also attenuated the effect of CXCL12-induced cholangiocarcinoma cell invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	C-X-C motif chemokine ligand 12	Homo sapiens	109-115
17275920-5	2007	The BCR-induced rapid expression of c-FLIP was not affected by inactivation of NF-kappaB, but was inhibited by either treatment with a PI3K inhibitor, LY294002, or expression of a dominant negative PI3K p85 subunit, both of which suppressed phosphorylation of Akt and sensitized BCR-stimulated A20 cells to Fas-mediated apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	CASP8 and FADD-like apoptosis regulator	Mus musculus	36-42
17275920-7	2007	Moreover, treatment with LY294002 also suppressed BCR-induced up-regulation of c-FLIP expression in spleen B cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	CASP8 and FADD-like apoptosis regulator	Mus musculus	79-85
17197703-8	2007	LY294002, an inhibitor of phosphoinositide 3-hydroxykinase, strongly inhibited the nuclear localization of SIRT1 in undifferentiated C2C12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	sirtuin 1	Mus musculus	107-112
17360480-7	2007	Lipoic acid-dependent Akt phosphorylation and inhibition of NF-kappaB activity were abolished by the PI3K inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	22-25
17465197-7	2007	In addition to butyrate, several HDAC inhibitors can induce differentiation in colon cancer cells and the responses may be enhanced by U0126, GW5074 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	histone deacetylase 9	Homo sapiens	33-37
17209046-3	2007	FGF-2 stimulation dramatically increased p27 phosphorylation at Ser-10 and Thr-187 using differential kinetics, and the FGF-2-induced p27 phosphorylation was completely blocked at both sites by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	fibroblast growth factor 2	Homo sapiens	0-5
17209046-3	2007	FGF-2 stimulation dramatically increased p27 phosphorylation at Ser-10 and Thr-187 using differential kinetics, and the FGF-2-induced p27 phosphorylation was completely blocked at both sites by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	fibroblast growth factor 2	Homo sapiens	120-125
17209046-3	2007	FGF-2 stimulation dramatically increased p27 phosphorylation at Ser-10 and Thr-187 using differential kinetics, and the FGF-2-induced p27 phosphorylation was completely blocked at both sites by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	dynactin subunit 6	Homo sapiens	134-137
17209046-7	2007	LY294002 blocked 64% of the cell proliferation stimulated by FGF-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	fibroblast growth factor 2	Homo sapiens	61-66
17158252-10	2007	Furthermore, inhibition of PI3K by LY-294002 completely inhibited trypsinogen activation caused by the bile acid TLC-S. Our results indicate that PI3K and its product, PIP(3), facilitate bile acid-induced [Ca(2+)](i) responses in pancreatic acinar cells through inhibition of SERCA-dependent Ca(2+) reloading into the ER and that bile acid-induced trypsinogen activation is mediated by PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-44	prolactin induced protein	Homo sapiens	168-171
17158602-6	2007	Furthermore, LY294002 or wortmannin inhibited Akt phosphorylation but had no effect on NF-kappaB translocation, which was blocked by helenalin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	46-49
17158602-9	2007	The results showed that LY294002 and curcumin blocked Akt translocation into nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	54-57
17465197-6	2007	The PI-3 kinase inhibitor LY294002 had little effect alone but enhanced the response of most HDAC inhibitors as did the raf inhibitor GW5074.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	histone deacetylase 9	Homo sapiens	93-97
17196679-6	2007	Similar simultaneous treatment with PI-3 kinase inhibitor LY294002 prominently blocked Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Homo sapiens	87-90
17107342-7	2007	The LPS-induced increase in Oct-2 protein was inhibited by LY294002 (a phosphoinositide 3-kinase inhibitor) post-transcriptionally, and the inhibition also resulted in a lower response of both resistin mRNA and promoter activity to LPS treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	POU domain, class 2, transcription factor 2	Mus musculus	28-33
17208315-7	2007	Additionally, OSM-enhanced ADAMTS-4 mRNA and MMP-13 expression was down-regulated by phosphatidylinositol 3-kinase (PI3K) and Akt/PKB inhibitors, LY294002 and NL-71-101.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	27-35
17093923-2	2007	Moreover, the protein kinase kinase/extracellular-signal-regulated kinase (MAPKK/ERK-MEK) inhibitor PD98059 accelerates insulin-mediated myogenesis, whereas the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 or blockade of mitochondrial respiration abrogates insulin-mediated myogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	209-217	mitogen-activated protein kinase kinase 7	Homo sapiens	85-88
17011750-6	2007	The Wnt3a-induced Akt activation was abolished by pre-treatment with PI3K inhibitor, LY294002 and Wortmanin, but not by MEK inhibitor, U0126, indicating that Wnt3a activates Akt via PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	wingless-type MMTV integration site family, member 3A	Mus musculus	4-9
17093923-2	2007	Moreover, the protein kinase kinase/extracellular-signal-regulated kinase (MAPKK/ERK-MEK) inhibitor PD98059 accelerates insulin-mediated myogenesis, whereas the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 or blockade of mitochondrial respiration abrogates insulin-mediated myogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	209-217	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	161-190
17011750-6	2007	The Wnt3a-induced Akt activation was abolished by pre-treatment with PI3K inhibitor, LY294002 and Wortmanin, but not by MEK inhibitor, U0126, indicating that Wnt3a activates Akt via PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	thymoma viral proto-oncogene 1	Mus musculus	18-21
17348861-5	2007	Furthermore, inhibitors of PI3K (LY294002 and Wortmannin), MEK1 (PD98059 and U0126), and Src family tyrosine kinases (PP2) decreased IGF-I-induced proliferation, and blocked ERK1/2 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	insulin like growth factor 1	Homo sapiens	133-138
17011750-6	2007	The Wnt3a-induced Akt activation was abolished by pre-treatment with PI3K inhibitor, LY294002 and Wortmanin, but not by MEK inhibitor, U0126, indicating that Wnt3a activates Akt via PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	wingless-type MMTV integration site family, member 3A	Mus musculus	158-163
17011750-6	2007	The Wnt3a-induced Akt activation was abolished by pre-treatment with PI3K inhibitor, LY294002 and Wortmanin, but not by MEK inhibitor, U0126, indicating that Wnt3a activates Akt via PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	thymoma viral proto-oncogene 1	Mus musculus	174-177
17210830-7	2007	In this regard, a phosphatidylinositol 3-kinase inhibitor, LY294002, blocked Akt phosphorylation without affecting eNOS phosphorylation and cGMP production by thrombin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Bos taurus	77-80
16820799-6	2007	Inhibited by LY294002, phospho-Bad (Ser136) expression increased in the peripheral area 3 h after tFCI, with suppression of Akt activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	124-127
17325368-5	2007	The PI3K-specific inhibitor LY294002 could suppress Akt phosphorylation, suggesting that influenza A virus-induced Akt phosphorylation is PI3K-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	52-55
17325368-5	2007	The PI3K-specific inhibitor LY294002 could suppress Akt phosphorylation, suggesting that influenza A virus-induced Akt phosphorylation is PI3K-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	115-118
17325368-7	2007	Blockage of PI3K/Akt activation by LY294002 and overexpression of the general receptor for phosphoinositides-1 PH domain (Grp1-PH) led to a reduction in virus yield.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	17-20
17130184-9	2007	The inhibitors of PI-3K wortmannin and LY294002 inhibited the chemotaxis and suppressed IL-8-evoked dephosphorylation and rephosphorylation of cofilin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
17130184-9	2007	The inhibitors of PI-3K wortmannin and LY294002 inhibited the chemotaxis and suppressed IL-8-evoked dephosphorylation and rephosphorylation of cofilin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	cofilin 1	Homo sapiens	143-150
17348861-6	2007	LY294002, Wortmannin and PP2 also blocked Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	42-45
17592551-8	2007	Apoptogenic Smac/DIABLO, which is constitutively expressed by TSC2-/- A+ cells, is down-regulated by IGF-1 even in the presence of LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	insulin like growth factor 1	Homo sapiens	101-106
17016676-5	2007	In normoxic open-chest rats, PI3K/Akt inhibitor LY294002 (LY; 0.3 mg/kg) given 5 min before test occlusion/reperfusion (I/R) did not affect infarct size (IS) normalized to the size of area at risk (AR).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-50	AKT serine/threonine kinase 1	Rattus norvegicus	34-37
17179444-5	2007	PI3K-C2alpha is uniquely less sensitive to the PI3K inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) than the other PI3K members, including p110alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-110	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	0-12
17179444-5	2007	PI3K-C2alpha is uniquely less sensitive to the PI3K inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) than the other PI3K members, including p110alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	0-12
17592551-8	2007	Apoptogenic Smac/DIABLO, which is constitutively expressed by TSC2-/- A+ cells, is down-regulated by IGF-1 even in the presence of LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	diablo IAP-binding mitochondrial protein	Homo sapiens	12-16
17592551-8	2007	Apoptogenic Smac/DIABLO, which is constitutively expressed by TSC2-/- A+ cells, is down-regulated by IGF-1 even in the presence of LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	diablo IAP-binding mitochondrial protein	Homo sapiens	17-23
17363506-3	2007	Although specific blockade of the PI3K-Akt pathway alone with inhibitors such as LY294002 did not induce cell death, it resulted in marked and selective enhancement of the induction of apoptosis by microtubule-destabilizing agents such as vincristine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	39-42
17184770-4	2007	Here we show that pIgA transcytosis was not restored in these cells when treated with the specific phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	phosphatidylinositol N-acetylglucosaminyltransferase subunit A	Canis lupus familiaris	18-22
17272774-8	2007	In addition, LY294002 was injected intracerebroventricularly to inhibit PI3-K/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
17272774-11	2007	Inhibition of PI3-K/Akt using LY294002 attenuated PC neuroprotection and promoted the expression of NF-kappaB, COX-2, and CD68.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Rattus norvegicus	20-23
17272774-11	2007	Inhibition of PI3-K/Akt using LY294002 attenuated PC neuroprotection and promoted the expression of NF-kappaB, COX-2, and CD68.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	111-116
17272774-11	2007	Inhibition of PI3-K/Akt using LY294002 attenuated PC neuroprotection and promoted the expression of NF-kappaB, COX-2, and CD68.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	Cd68 molecule	Rattus norvegicus	122-126
17300148-12	2007	However, both PD98059 and LY294002 significantly decrease thioredoxin mRNA expression in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	thioredoxin	Homo sapiens	58-69
17184770-9	2007	In addition, colocalization of internalized pIgA with subunits of both retromer subcomplexes throughout the transcytotic pathway was substantially reduced by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	phosphatidylinositol N-acetylglucosaminyltransferase subunit A	Canis lupus familiaris	44-48
17158870-3	2007	Relative to wild-type MEF cells, MKK4-null MEF cells were highly susceptible to apoptosis by LY294002, paclitaxel, or serum starvation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	mitogen-activated protein kinase kinase 4	Mus musculus	33-37
17196258-5	2007	VEGF mRNA expression in C2 cells was counteracted by LY294002 and rapamycin, suggesting involvement of the PI3-kinase/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	vascular endothelial growth factor A	Canis lupus familiaris	0-4
17464346-10	2007	The increased secretion of TNF-alpha and sICAM-1 and the increased activity of NF-kappaB by ADMA were altered by SB203580 (5 micromol/L) or PD98059 (20 micromol/L), but not by LY294002 (20 micromol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	nuclear factor kappa B subunit 1	Homo sapiens	79-88
17187756-3	2007	In this report, we suggest phosphatidylinositol 3-OH kinase (PI3K)/Akt signaling is also necessary for TGF-beta-induced EMT in lens epithelial cells by showing that LY294002, an inhibitor of the p110 catalytic subunit of PI3K, blocked the expression of alpha-smooth muscle actin (alpha-SMA) and morphological changes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	AKT serine/threonine kinase 1	Homo sapiens	67-70
17187756-3	2007	In this report, we suggest phosphatidylinositol 3-OH kinase (PI3K)/Akt signaling is also necessary for TGF-beta-induced EMT in lens epithelial cells by showing that LY294002, an inhibitor of the p110 catalytic subunit of PI3K, blocked the expression of alpha-smooth muscle actin (alpha-SMA) and morphological changes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	transforming growth factor beta 1	Homo sapiens	103-111
16950602-4	2007	Like insulin, EGCG induced FOXO1a phosphorylation is abolished by the PtdIns 3-kinase inhibitor LY294002 but not by PD98059 (an inhibitor of mitogen-activated protein kinase cascade) or by rapamycin (an inhibitor of signalling to p70 S6 kinase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	insulin	Homo sapiens	5-12
16950602-4	2007	Like insulin, EGCG induced FOXO1a phosphorylation is abolished by the PtdIns 3-kinase inhibitor LY294002 but not by PD98059 (an inhibitor of mitogen-activated protein kinase cascade) or by rapamycin (an inhibitor of signalling to p70 S6 kinase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	forkhead box O1	Homo sapiens	27-33
17242177-10	2007	Indeed, HGF increased mRNA and protein expression of bcl-2 downregulated by FFAs-treatment; moreover, pre-treatment with the specific PI3-kinase inhibitor LY294002, significantly abolished the protective effect of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	hepatocyte growth factor	Rattus norvegicus	8-11
17046344-7	2007	The pretreatment of MG-63 cells with either one of inhibitors for phosphoinositide 3-kinase (PI3K), wortmannin or LY294002 prevented Akt and Bad phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Homo sapiens	133-136
17318772-7	2007	The PI3K pathway inhibitors LY294002 and wortmannin abolished the stimulation of cell proliferation by insulin, indicating a role for this pathway in the cellular response to insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	insulin	Homo sapiens	103-110
17318772-7	2007	The PI3K pathway inhibitors LY294002 and wortmannin abolished the stimulation of cell proliferation by insulin, indicating a role for this pathway in the cellular response to insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	insulin	Homo sapiens	175-182
24557623-12	2007	PI3K inhibitors, LY294002 and wortmannin, inhibited HIF-1alpha and TfR expressions induced by UVB (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
24557623-12	2007	PI3K inhibitors, LY294002 and wortmannin, inhibited HIF-1alpha and TfR expressions induced by UVB (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	transferrin receptor	Homo sapiens	67-70
17242176-7	2007	In addition, we have shown that the regulation of GSK-3alpha and GSK-3beta in cultured oocytes by soluble KL is accomplished through PI3K, since the PI3K-specific inhibitor LY294002 completely abolished the KL-induced phosphorylation of GSK-3alpha and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	glycogen synthase kinase 3 alpha	Mus musculus	50-60
17242177-10	2007	Indeed, HGF increased mRNA and protein expression of bcl-2 downregulated by FFAs-treatment; moreover, pre-treatment with the specific PI3-kinase inhibitor LY294002, significantly abolished the protective effect of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	BCL2, apoptosis regulator	Rattus norvegicus	53-58
17242176-7	2007	In addition, we have shown that the regulation of GSK-3alpha and GSK-3beta in cultured oocytes by soluble KL is accomplished through PI3K, since the PI3K-specific inhibitor LY294002 completely abolished the KL-induced phosphorylation of GSK-3alpha and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	glycogen synthase kinase 3 beta	Mus musculus	65-74
17242176-7	2007	In addition, we have shown that the regulation of GSK-3alpha and GSK-3beta in cultured oocytes by soluble KL is accomplished through PI3K, since the PI3K-specific inhibitor LY294002 completely abolished the KL-induced phosphorylation of GSK-3alpha and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	glycogen synthase kinase 3 alpha	Mus musculus	237-247
17242176-7	2007	In addition, we have shown that the regulation of GSK-3alpha and GSK-3beta in cultured oocytes by soluble KL is accomplished through PI3K, since the PI3K-specific inhibitor LY294002 completely abolished the KL-induced phosphorylation of GSK-3alpha and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	glycogen synthase kinase 3 beta	Mus musculus	252-261
17070899-5	2007	The PI3K/Akt pathway was further examined using pharmacological inhibitors (LY294002 and wortmannin), Akt siRNA, constitutively active Akt adenovirus and treatment with IGF-1/insulin in the SKOV-3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	9-12
17242177-10	2007	Indeed, HGF increased mRNA and protein expression of bcl-2 downregulated by FFAs-treatment; moreover, pre-treatment with the specific PI3-kinase inhibitor LY294002, significantly abolished the protective effect of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	hepatocyte growth factor	Rattus norvegicus	214-217
17070899-9	2007	Furthermore, IGF-1 and insulin stimulated SKOV-3 migration by altering the balance between uPA and PAI-1 to favor uPA, and the enhanced migration was attenuated by treatment with LY294002 indicating PI3K/Akt in this pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	insulin like growth factor 1	Homo sapiens	13-18
17070899-9	2007	Furthermore, IGF-1 and insulin stimulated SKOV-3 migration by altering the balance between uPA and PAI-1 to favor uPA, and the enhanced migration was attenuated by treatment with LY294002 indicating PI3K/Akt in this pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	insulin	Homo sapiens	23-30
16955404-4	2007	Actions of IGF-I to increase cell number were blocked by treatment with the mitogen activated protein kinase kinase (MAPKK) inhibitor PD 98059 whereas the phosphatidylinositol 3-kinase (PI3K) inhibitor LY 294002 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-211	insulin like growth factor 1	Bos taurus	11-16
17070899-9	2007	Furthermore, IGF-1 and insulin stimulated SKOV-3 migration by altering the balance between uPA and PAI-1 to favor uPA, and the enhanced migration was attenuated by treatment with LY294002 indicating PI3K/Akt in this pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	plasminogen activator, urokinase	Homo sapiens	91-94
17070899-9	2007	Furthermore, IGF-1 and insulin stimulated SKOV-3 migration by altering the balance between uPA and PAI-1 to favor uPA, and the enhanced migration was attenuated by treatment with LY294002 indicating PI3K/Akt in this pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	serpin family E member 1	Homo sapiens	99-104
17070899-9	2007	Furthermore, IGF-1 and insulin stimulated SKOV-3 migration by altering the balance between uPA and PAI-1 to favor uPA, and the enhanced migration was attenuated by treatment with LY294002 indicating PI3K/Akt in this pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	plasminogen activator, urokinase	Homo sapiens	114-117
17070899-9	2007	Furthermore, IGF-1 and insulin stimulated SKOV-3 migration by altering the balance between uPA and PAI-1 to favor uPA, and the enhanced migration was attenuated by treatment with LY294002 indicating PI3K/Akt in this pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	AKT serine/threonine kinase 1	Homo sapiens	204-207
16955404-5	2007	Conversely, LY 294002 but not PD 98059 blocked actions of IGF-I to inhibit induction of apoptosis caused by heat shock.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-21	insulin like growth factor 1	Bos taurus	58-63
17220879-6	2007	Finally, the phosphatidylinositol 3-kinase (PI(3)K) inhibitor LY294002 affects the frequency of pseudopod generation, but not the accuracy of selection, suggesting that PI(3)K regulates the underlying mechanism of cell movement, rather than control of direction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	13-42
17107963-7	2007	Further studies revealed that phosphatidylinositol 3-kinase inhibitors LY294002 and wortmannin induced phosphorylated ERK Tyr-204 and pMdm2 Ser-166 phosphorylations in hepatocytes in culture and in rat hepatocytes in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	Eph receptor B1	Rattus norvegicus	118-121
17141276-7	2007	The high glucose-induced downregulation of GLUT-1 was blocked by Wortmanin, LY 294002 (PI-3 kinase inhibitors) and Akt (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-85	solute carrier family 2 member 1	Homo sapiens	43-49
17141276-7	2007	The high glucose-induced downregulation of GLUT-1 was blocked by Wortmanin, LY 294002 (PI-3 kinase inhibitors) and Akt (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-85	AKT serine/threonine kinase 1	Homo sapiens	87-118
17222412-3	2007	PI3K inhibitors, LY294002 and wortmannin, inhibited the activation of Akt and ERK following the treatment with PS-liposomes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	AKT serine/threonine kinase 1	Homo sapiens	70-73
17234785-7	2007	Parallel experiments in neuroblastoma cell lines revealed that activation of Akt by insulin-like growth factor (IGF)-I significantly inhibited tumor necrosis factor-related apoptosis-inducing ligand- or chemotherapy-induced apoptosis in a PI3K-dependent manner because the PI3K inhibitor LY294002 completely reversed the IGF-I-mediated protection of neuroblastoma cells from apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	288-296	AKT serine/threonine kinase 1	Homo sapiens	77-80
17222412-3	2007	PI3K inhibitors, LY294002 and wortmannin, inhibited the activation of Akt and ERK following the treatment with PS-liposomes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	mitogen-activated protein kinase 1	Homo sapiens	78-81
17067555-9	2007	COX-2 expression in response to IL-1beta was attenuated by pretreatment with SB203580, SP600125, and LY294002, but not with PD98059, suggesting the involvement of p38 MAPK, JNK, and PI3K in this response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	interleukin 1 beta	Homo sapiens	32-40
17067555-9	2007	COX-2 expression in response to IL-1beta was attenuated by pretreatment with SB203580, SP600125, and LY294002, but not with PD98059, suggesting the involvement of p38 MAPK, JNK, and PI3K in this response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	mitogen-activated protein kinase 14	Homo sapiens	163-166
17067555-9	2007	COX-2 expression in response to IL-1beta was attenuated by pretreatment with SB203580, SP600125, and LY294002, but not with PD98059, suggesting the involvement of p38 MAPK, JNK, and PI3K in this response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	mitogen-activated protein kinase 1	Homo sapiens	167-171
17067555-9	2007	COX-2 expression in response to IL-1beta was attenuated by pretreatment with SB203580, SP600125, and LY294002, but not with PD98059, suggesting the involvement of p38 MAPK, JNK, and PI3K in this response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	mitogen-activated protein kinase 8	Homo sapiens	173-176
17234779-4	2007	Blockade of PI3K or ILK signaling with pharmacologic inhibitors LY294002 or QLT0267 specifically inhibited stroma-induced phosphorylation of Akt and glycogen synthase kinase 3beta, suppressed STAT3 and ERK1/2 activation, and decreased Notch1 and Hes1 expression in leukemic cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	integrin linked kinase	Homo sapiens	20-23
17234779-4	2007	Blockade of PI3K or ILK signaling with pharmacologic inhibitors LY294002 or QLT0267 specifically inhibited stroma-induced phosphorylation of Akt and glycogen synthase kinase 3beta, suppressed STAT3 and ERK1/2 activation, and decreased Notch1 and Hes1 expression in leukemic cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Homo sapiens	141-144
17125737-3	2007	LY294002 inhibits the angiogenin-induced protein kinase B/Akt activation and also angiogenin-induced cell migration in vitro as well as angiogenesis in chick embryo chorioallantoic membrane in vivo without affecting nuclear translocation of angiogenin in HUVE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribonuclease A family member k6	Gallus gallus	22-32
17234779-4	2007	Blockade of PI3K or ILK signaling with pharmacologic inhibitors LY294002 or QLT0267 specifically inhibited stroma-induced phosphorylation of Akt and glycogen synthase kinase 3beta, suppressed STAT3 and ERK1/2 activation, and decreased Notch1 and Hes1 expression in leukemic cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	glycogen synthase kinase 3 beta	Homo sapiens	149-179
17234779-4	2007	Blockade of PI3K or ILK signaling with pharmacologic inhibitors LY294002 or QLT0267 specifically inhibited stroma-induced phosphorylation of Akt and glycogen synthase kinase 3beta, suppressed STAT3 and ERK1/2 activation, and decreased Notch1 and Hes1 expression in leukemic cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	signal transducer and activator of transcription 3	Homo sapiens	192-197
17234779-4	2007	Blockade of PI3K or ILK signaling with pharmacologic inhibitors LY294002 or QLT0267 specifically inhibited stroma-induced phosphorylation of Akt and glycogen synthase kinase 3beta, suppressed STAT3 and ERK1/2 activation, and decreased Notch1 and Hes1 expression in leukemic cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	mitogen-activated protein kinase 3	Homo sapiens	202-208
17234779-4	2007	Blockade of PI3K or ILK signaling with pharmacologic inhibitors LY294002 or QLT0267 specifically inhibited stroma-induced phosphorylation of Akt and glycogen synthase kinase 3beta, suppressed STAT3 and ERK1/2 activation, and decreased Notch1 and Hes1 expression in leukemic cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	notch receptor 1	Homo sapiens	235-241
17234779-4	2007	Blockade of PI3K or ILK signaling with pharmacologic inhibitors LY294002 or QLT0267 specifically inhibited stroma-induced phosphorylation of Akt and glycogen synthase kinase 3beta, suppressed STAT3 and ERK1/2 activation, and decreased Notch1 and Hes1 expression in leukemic cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	hes family bHLH transcription factor 1	Homo sapiens	246-250
17234779-6	2007	In turn, leukemic cells growing in direct contact with bone marrow stromal elements induce activation of Akt, ERK1/2, and STAT3 signaling in MSC, accompanied by significant increase in Hes1 and Bcl-2 proteins, which were all suppressed by QLT0267 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	AKT serine/threonine kinase 1	Homo sapiens	105-108
17234779-6	2007	In turn, leukemic cells growing in direct contact with bone marrow stromal elements induce activation of Akt, ERK1/2, and STAT3 signaling in MSC, accompanied by significant increase in Hes1 and Bcl-2 proteins, which were all suppressed by QLT0267 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	BCL2 apoptosis regulator	Homo sapiens	194-199
17125737-3	2007	LY294002 inhibits the angiogenin-induced protein kinase B/Akt activation and also angiogenin-induced cell migration in vitro as well as angiogenesis in chick embryo chorioallantoic membrane in vivo without affecting nuclear translocation of angiogenin in HUVE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	58-61
17125737-3	2007	LY294002 inhibits the angiogenin-induced protein kinase B/Akt activation and also angiogenin-induced cell migration in vitro as well as angiogenesis in chick embryo chorioallantoic membrane in vivo without affecting nuclear translocation of angiogenin in HUVE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribonuclease A family member k6	Gallus gallus	82-92
17125737-3	2007	LY294002 inhibits the angiogenin-induced protein kinase B/Akt activation and also angiogenin-induced cell migration in vitro as well as angiogenesis in chick embryo chorioallantoic membrane in vivo without affecting nuclear translocation of angiogenin in HUVE cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribonuclease A family member k6	Gallus gallus	82-92
17182072-8	2007	Treatment of MDA-MB-231 cells with PI 3-kinase inhibitors, LY294002 and Wortmannin, inhibited the EGF-induced expression of FAS and nuclear translocation of SREBP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	fatty acid synthase	Homo sapiens	124-127
17405917-6	2007	For example, genes encoding the PAF receptor, PAI-1, PlA2 (group V), IL-13 receptor (alpha2), and GTP cyclohydrolase 1, were upregulated after LPS treatment, but this upregulation was counteracted by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	GTP cyclohydrolase 1	Mus musculus	98-118
17182072-8	2007	Treatment of MDA-MB-231 cells with PI 3-kinase inhibitors, LY294002 and Wortmannin, inhibited the EGF-induced expression of FAS and nuclear translocation of SREBP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	sterol regulatory element binding transcription factor 1	Homo sapiens	157-164
16940564-7	2007	Blocking Akt activation using a phosphatidylinositol 3-kinase inhibitor, LY294002 (20 muM), or expressing dominant negative (inactive) Akt increased DCVC-induced RPTC necrosis to 42%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Homo sapiens	9-12
17404021-12	2007	Furthermore, inhibition of Akt by specific phosphatidyinositol-3-kinase (PI3K)-Akt inhibitors (Wortmannin, and LY294002) synergistically increased the efficacy of the paclitaxel-induced apoptosis in both cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Homo sapiens	27-30
17404021-12	2007	Furthermore, inhibition of Akt by specific phosphatidyinositol-3-kinase (PI3K)-Akt inhibitors (Wortmannin, and LY294002) synergistically increased the efficacy of the paclitaxel-induced apoptosis in both cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Homo sapiens	79-82
17405917-6	2007	For example, genes encoding the PAF receptor, PAI-1, PlA2 (group V), IL-13 receptor (alpha2), and GTP cyclohydrolase 1, were upregulated after LPS treatment, but this upregulation was counteracted by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	toll-like receptor 4	Mus musculus	143-146
16842970-7	2007	In the PTEN-positive prostate-derived cell lines PNT2, PNT1a and P4E6, PI3K inhibition by LY294002 caused rapid dephosphorylation of PKB at ser473 (T(1/2)&lt;2 min), leading to its inactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	phosphatase and tensin homolog	Homo sapiens	7-11
17126821-7	2007	Inhibitors of PI3-kinase, LY294002 and wortmannin, significantly attenuated the IGF-I-upregulated ClC-2 expression and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	insulin like growth factor 1	Homo sapiens	80-85
17126821-7	2007	Inhibitors of PI3-kinase, LY294002 and wortmannin, significantly attenuated the IGF-I-upregulated ClC-2 expression and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	chloride voltage-gated channel 2	Homo sapiens	98-103
17136496-8	2007	The inhibition of PI-3-kinase-Akt pathway by LY-294002 or wortmannin significantly decreased the protective effect of the Hsp16.2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-54	AKT serine/threonine kinase 1	Homo sapiens	30-33
17005940-10	2007	Moreover, this cell proliferation stimulated by FGF2 and VEGF was dose-dependently inhibited (P &lt; 0.05) by PD98059 (a selective mitogen-activated protein kinase 1 and 2 [MAP2K1/2, also termed MEK1/2] inhibitor) or by LY294002 (a selective phosphoinositide 3-kinase [PI3K] inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	fibroblast growth factor 2	Ovis aries	48-52
17005940-10	2007	Moreover, this cell proliferation stimulated by FGF2 and VEGF was dose-dependently inhibited (P &lt; 0.05) by PD98059 (a selective mitogen-activated protein kinase 1 and 2 [MAP2K1/2, also termed MEK1/2] inhibitor) or by LY294002 (a selective phosphoinositide 3-kinase [PI3K] inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	vascular endothelial growth factor A	Ovis aries	57-61
17005940-10	2007	Moreover, this cell proliferation stimulated by FGF2 and VEGF was dose-dependently inhibited (P &lt; 0.05) by PD98059 (a selective mitogen-activated protein kinase 1 and 2 [MAP2K1/2, also termed MEK1/2] inhibitor) or by LY294002 (a selective phosphoinositide 3-kinase [PI3K] inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	mitogen-activated protein kinase 1	Ovis aries	131-171
17005940-10	2007	Moreover, this cell proliferation stimulated by FGF2 and VEGF was dose-dependently inhibited (P &lt; 0.05) by PD98059 (a selective mitogen-activated protein kinase 1 and 2 [MAP2K1/2, also termed MEK1/2] inhibitor) or by LY294002 (a selective phosphoinositide 3-kinase [PI3K] inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	dual specificity mitogen-activated protein kinase kinase 1	Ovis aries	173-181
16842970-7	2007	In the PTEN-positive prostate-derived cell lines PNT2, PNT1a and P4E6, PI3K inhibition by LY294002 caused rapid dephosphorylation of PKB at ser473 (T(1/2)&lt;2 min), leading to its inactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 1	Homo sapiens	133-136
16842970-8	2007	In the PTEN-null line LNCaP, LY294002-induced PKB dephosphorylation was much slower (T(1/2)&gt;20 min), but in PC3 cells (also PTEN-null) it was only slightly slower than in PTEN-positive cells (T(1/2)=3 min).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	phosphatase and tensin homolog	Homo sapiens	7-11
16842970-8	2007	In the PTEN-null line LNCaP, LY294002-induced PKB dephosphorylation was much slower (T(1/2)&gt;20 min), but in PC3 cells (also PTEN-null) it was only slightly slower than in PTEN-positive cells (T(1/2)=3 min).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	keratin 6A	Homo sapiens	111-114
16842970-8	2007	In the PTEN-null line LNCaP, LY294002-induced PKB dephosphorylation was much slower (T(1/2)&gt;20 min), but in PC3 cells (also PTEN-null) it was only slightly slower than in PTEN-positive cells (T(1/2)=3 min).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	phosphatase and tensin homolog	Homo sapiens	127-131
16842970-8	2007	In the PTEN-null line LNCaP, LY294002-induced PKB dephosphorylation was much slower (T(1/2)&gt;20 min), but in PC3 cells (also PTEN-null) it was only slightly slower than in PTEN-positive cells (T(1/2)=3 min).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	phosphatase and tensin homolog	Homo sapiens	127-131
16842970-11	2007	SiRNA-mediated knockdown of SHIP2 expression markedly slowed PKB inactivation in response to LY294002 in PC3 but not in other SHIP2-positive cells, whereas knockdown of PTEN expression in PNT2, PNT1a and P4E6 resulted in higher steady-state levels of PKB phosphorylation and slowed, but did not prevent, LY294002-induced PKB inactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	inositol polyphosphate phosphatase like 1	Homo sapiens	28-33
16842970-11	2007	SiRNA-mediated knockdown of SHIP2 expression markedly slowed PKB inactivation in response to LY294002 in PC3 but not in other SHIP2-positive cells, whereas knockdown of PTEN expression in PNT2, PNT1a and P4E6 resulted in higher steady-state levels of PKB phosphorylation and slowed, but did not prevent, LY294002-induced PKB inactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Homo sapiens	61-64
16842970-11	2007	SiRNA-mediated knockdown of SHIP2 expression markedly slowed PKB inactivation in response to LY294002 in PC3 but not in other SHIP2-positive cells, whereas knockdown of PTEN expression in PNT2, PNT1a and P4E6 resulted in higher steady-state levels of PKB phosphorylation and slowed, but did not prevent, LY294002-induced PKB inactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	keratin 6A	Homo sapiens	105-108
16842970-11	2007	SiRNA-mediated knockdown of SHIP2 expression markedly slowed PKB inactivation in response to LY294002 in PC3 but not in other SHIP2-positive cells, whereas knockdown of PTEN expression in PNT2, PNT1a and P4E6 resulted in higher steady-state levels of PKB phosphorylation and slowed, but did not prevent, LY294002-induced PKB inactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	304-312	inositol polyphosphate phosphatase like 1	Homo sapiens	28-33
17714594-6	2007	Both the large tidal volume ventilation of Akt mutant mice and the pharmacological inhibition of Akt with LY294002 attenuated neutrophil sequestration, MIP-2 protein production, and Akt and eNOS activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	thymoma viral proto-oncogene 1	Mus musculus	97-100
17714594-6	2007	Both the large tidal volume ventilation of Akt mutant mice and the pharmacological inhibition of Akt with LY294002 attenuated neutrophil sequestration, MIP-2 protein production, and Akt and eNOS activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	chemokine (C-X-C motif) ligand 2	Mus musculus	152-157
17714594-6	2007	Both the large tidal volume ventilation of Akt mutant mice and the pharmacological inhibition of Akt with LY294002 attenuated neutrophil sequestration, MIP-2 protein production, and Akt and eNOS activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	thymoma viral proto-oncogene 1	Mus musculus	97-100
17055484-11	2007	HGF also activated AKT, while inhibition of AKT by LY294002 induced a modest decrease of HGF-induced HBMEC migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	44-47
17492691-9	2007	Furthermore, NMDA receptor-mediated Akt activation was reversed by combined treatment with LY294002, the specific blockade of PI-3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	AKT serine/threonine kinase 1	Homo sapiens	36-39
17045834-6	2007	Moreover, inhibitors of PI3K (LY294002) and eNOS (l-NAME) can attenuate CD151-induced cell proliferation and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	CD151 molecule (Raph blood group)	Homo sapiens	72-77
16973406-4	2007	LY294002 but not RAD completely inhibited phosphorylation of Akt, while both inhibitors decreased phosphorylation of the S6 ribosomal protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
16973406-9	2007	Differentiation studies indicated an increase in alpha-smooth muscle actin expression relative to beta-actin (western blotting), with cytochemistry confirming that all doses of RAD and LY294002 increased the proportion of alpha-smooth muscle actin positive cells, and hence myofibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	actin gamma 2, smooth muscle	Rattus norvegicus	49-74
16973406-9	2007	Differentiation studies indicated an increase in alpha-smooth muscle actin expression relative to beta-actin (western blotting), with cytochemistry confirming that all doses of RAD and LY294002 increased the proportion of alpha-smooth muscle actin positive cells, and hence myofibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	actin, beta	Rattus norvegicus	98-108
16973406-9	2007	Differentiation studies indicated an increase in alpha-smooth muscle actin expression relative to beta-actin (western blotting), with cytochemistry confirming that all doses of RAD and LY294002 increased the proportion of alpha-smooth muscle actin positive cells, and hence myofibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	actin gamma 2, smooth muscle	Rattus norvegicus	222-247
17055484-11	2007	HGF also activated AKT, while inhibition of AKT by LY294002 induced a modest decrease of HGF-induced HBMEC migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	hepatocyte growth factor	Homo sapiens	89-92
17143555-9	2007	SB203580 and SP600125 (p38 and JNK inhibitors) reduced diosgenin-induced DNA fragmentation whereas U0126 and LY294002 (MEK and PI3 kinase/Akt inhibitors) caused an amplification of proapoptotic effect of diosgenin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	mitogen-activated protein kinase kinase 7	Homo sapiens	119-122
17143528-7	2007	PD98059 and LY294002 effectively suppressed pRB phosphorylation in A549 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	RB transcriptional corepressor 1	Homo sapiens	44-47
17143555-9	2007	SB203580 and SP600125 (p38 and JNK inhibitors) reduced diosgenin-induced DNA fragmentation whereas U0126 and LY294002 (MEK and PI3 kinase/Akt inhibitors) caused an amplification of proapoptotic effect of diosgenin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	AKT serine/threonine kinase 1	Homo sapiens	138-141
17182580-8	2007	The induced phosphorylation of SNAP-23 and syntaxins 2 and 4 was blocked by Rp-8-Br-PET-cGMP and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	synaptosome associated protein 23	Rattus norvegicus	31-38
16784840-7	2007	TNF-alpha-induced Lnk was also inhibited by a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	tumor necrosis factor	Homo sapiens	0-9
16784840-7	2007	TNF-alpha-induced Lnk was also inhibited by a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	SH2B adaptor protein 3	Homo sapiens	18-21
17018579-6	2007	Furthermore, the changes in ligand sensitivity of CNGA3 + CNGB3 channels were prevented by inhibition of phosphatidylinositol 3-kinase (PI3-kinase) using wortmannin or 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002), which suggests that phospholipid metabolism can regulate the channels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	cyclic nucleotide gated channel subunit alpha 3	Homo sapiens	50-55
17003231-6	2007	In contrast, the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, 20 microM] did not reduce aortic or venous H2O2-induced contraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	17-46
17237271-7	2007	The interleukin 6-stimulated activation of STAT3 and Akt was inhibited not only by atiprimod but also by LY294002, a phosphoinositide-3-kinase-specific inhibitor, and by NS398, a cyclooxygenase-2-selective inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	interleukin 6	Homo sapiens	4-17
17237271-7	2007	The interleukin 6-stimulated activation of STAT3 and Akt was inhibited not only by atiprimod but also by LY294002, a phosphoinositide-3-kinase-specific inhibitor, and by NS398, a cyclooxygenase-2-selective inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	signal transducer and activator of transcription 3	Homo sapiens	43-48
17237271-7	2007	The interleukin 6-stimulated activation of STAT3 and Akt was inhibited not only by atiprimod but also by LY294002, a phosphoinositide-3-kinase-specific inhibitor, and by NS398, a cyclooxygenase-2-selective inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	53-56
17164836-7	2007	The phosphatidylinositol-3" kinase (PI3-K) inhibitor LY294002 completely blocked IGF-1 and aldosterone induced and co-induced currents.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-34
17164836-7	2007	The phosphatidylinositol-3" kinase (PI3-K) inhibitor LY294002 completely blocked IGF-1 and aldosterone induced and co-induced currents.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	insulin like growth factor 1	Homo sapiens	81-86
17164836-8	2007	As assessed by Western blotting, protein levels of the serum-, and glucocorticoid-induced kinase (Sgk1) were directly and proportionally related to the current induced by either or both IGF-1 and aldosterone, effects also blocked by the PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	253-261	serum/glucocorticoid regulated kinase 1	Homo sapiens	98-102
17164836-8	2007	As assessed by Western blotting, protein levels of the serum-, and glucocorticoid-induced kinase (Sgk1) were directly and proportionally related to the current induced by either or both IGF-1 and aldosterone, effects also blocked by the PI3-K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	253-261	insulin like growth factor 1	Homo sapiens	186-191
17259347-8	2007	ERRalpha1-activated transcription in BT-474 cells was inhibited by disruption of ErbB2/epidermal growth factor receptor signaling with trastuzumab or gefitinib or inactivation of downstream components of this signaling, MAPK kinase/MAPK, and phosphatidylinositol-3-OH kinase/Akt, with U0126 or LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	294-302	erb-b2 receptor tyrosine kinase 2	Homo sapiens	81-86
17259349-8	2007	Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway was found to regulate PDCD4 expression because inhibition of PI3K by LY294002 and wortmannin or of mTOR by rapamycin induced PDCD4 protein and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-29
17259349-8	2007	Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway was found to regulate PDCD4 expression because inhibition of PI3K by LY294002 and wortmannin or of mTOR by rapamycin induced PDCD4 protein and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	AKT serine/threonine kinase 1	Homo sapiens	37-40
17259349-8	2007	Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway was found to regulate PDCD4 expression because inhibition of PI3K by LY294002 and wortmannin or of mTOR by rapamycin induced PDCD4 protein and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	mechanistic target of rapamycin kinase	Homo sapiens	41-70
17259349-8	2007	Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway was found to regulate PDCD4 expression because inhibition of PI3K by LY294002 and wortmannin or of mTOR by rapamycin induced PDCD4 protein and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	mechanistic target of rapamycin kinase	Homo sapiens	72-76
17259349-8	2007	Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway was found to regulate PDCD4 expression because inhibition of PI3K by LY294002 and wortmannin or of mTOR by rapamycin induced PDCD4 protein and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	programmed cell death 4	Homo sapiens	118-123
17259349-8	2007	Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway was found to regulate PDCD4 expression because inhibition of PI3K by LY294002 and wortmannin or of mTOR by rapamycin induced PDCD4 protein and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	mechanistic target of rapamycin kinase	Homo sapiens	195-199
17259349-8	2007	Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway was found to regulate PDCD4 expression because inhibition of PI3K by LY294002 and wortmannin or of mTOR by rapamycin induced PDCD4 protein and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	programmed cell death 4	Homo sapiens	221-226
17534123-8	2007	Phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin and LY294002 abolished the effect of RSVL on p53 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	tumor protein p53	Homo sapiens	105-108
18523362-5	2007	RESULTS: PI3K inhibitors LY294002 and LY303511 were shown to suppress TNF-alpha expression that is stimulated by GM3 in B16 cells, suggesting that the GM3 signal is located upstream of the PI3K-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	eiger	Drosophila melanogaster	70-79
18523362-5	2007	RESULTS: PI3K inhibitors LY294002 and LY303511 were shown to suppress TNF-alpha expression that is stimulated by GM3 in B16 cells, suggesting that the GM3 signal is located upstream of the PI3K-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	granulocyte macrophage antigen 3	Mus musculus	113-116
18523362-5	2007	RESULTS: PI3K inhibitors LY294002 and LY303511 were shown to suppress TNF-alpha expression that is stimulated by GM3 in B16 cells, suggesting that the GM3 signal is located upstream of the PI3K-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	granulocyte macrophage antigen 3	Mus musculus	151-154
18523362-5	2007	RESULTS: PI3K inhibitors LY294002 and LY303511 were shown to suppress TNF-alpha expression that is stimulated by GM3 in B16 cells, suggesting that the GM3 signal is located upstream of the PI3K-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	thymoma viral proto-oncogene 1	Mus musculus	194-197
17015027-11	2007	Akt was also phosphorylated in NSCLC cells after exposure to nicotine; this effect was inhibited by the PI3K inhibitor LY294002 and antagonists to the neuronal-type nAChR, but not to the muscle-type receptor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Homo sapiens	0-3
17015027-11	2007	Akt was also phosphorylated in NSCLC cells after exposure to nicotine; this effect was inhibited by the PI3K inhibitor LY294002 and antagonists to the neuronal-type nAChR, but not to the muscle-type receptor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	165-170
17018579-6	2007	Furthermore, the changes in ligand sensitivity of CNGA3 + CNGB3 channels were prevented by inhibition of phosphatidylinositol 3-kinase (PI3-kinase) using wortmannin or 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002), which suggests that phospholipid metabolism can regulate the channels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	cyclic nucleotide gated channel subunit beta 3	Homo sapiens	58-63
17071610-7	2006	CEACAM1 binding triggered a phosphatidylinositol 3-kinase-dependent activation of the protein kinase Akt without influencing the activity of extracellular signal-related kinase ERK, whereas the phosphatidylinositol 3-kinase-specific inhibitor LY294002 effectively blocked the protective effect of CEACAM1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	243-251	CEA cell adhesion molecule 1	Homo sapiens	0-7
17068339-6	2006	We found that insulin-induced ERK1/2 and Akt kinase activities were completely abolished 10 min after inhibition of the corresponding upstream kinases with PD98059 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	insulin	Homo sapiens	14-21
17068339-6	2006	We found that insulin-induced ERK1/2 and Akt kinase activities were completely abolished 10 min after inhibition of the corresponding upstream kinases with PD98059 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	mitogen-activated protein kinase 3	Homo sapiens	30-36
17068339-6	2006	We found that insulin-induced ERK1/2 and Akt kinase activities were completely abolished 10 min after inhibition of the corresponding upstream kinases with PD98059 and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	AKT serine/threonine kinase 1	Homo sapiens	41-44
16960136-8	2007	Inhibition of the phosphoinositide-3-kinase (PI3-K)/Akt pathway by LY294002 significantly reduced the number of newly formed neurospheres, which indicates that this is an essential pathway for neural stem cell self-renewal.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	thymoma viral proto-oncogene 1	Mus musculus	52-55
17313857-13	2006	LY294002 dose-dependently inhibited the angiogenesis (P &lt; 0.05 or P &lt; 0.01) 15 mmol/L and 30 mmol/L D-glucose dose-dependently inhibited the phosphorylation of p85/P13K and Akt (P &lt; 0.05 and P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	174-182
17071610-7	2006	CEACAM1 binding triggered a phosphatidylinositol 3-kinase-dependent activation of the protein kinase Akt without influencing the activity of extracellular signal-related kinase ERK, whereas the phosphatidylinositol 3-kinase-specific inhibitor LY294002 effectively blocked the protective effect of CEACAM1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	243-251	AKT serine/threonine kinase 1	Homo sapiens	101-104
16817229-6	2006	The IL-6 synthesis stimulated by PDGF-BB was markedly enhanced by LY294002 and wortmannin, inhibitors of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	interleukin 6	Mus musculus	4-8
16817229-7	2006	Wortmannin and LY294002 suppressed the PDGF-BB-induced phosphorylation of Akt and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	thymoma viral proto-oncogene 1	Mus musculus	74-77
16817229-7	2006	Wortmannin and LY294002 suppressed the PDGF-BB-induced phosphorylation of Akt and GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	glycogen synthase kinase 3 beta	Mus musculus	82-91
17178855-8	2006	The role of phosphatidylinositol-3 kinase (PI3K)/Akt in mediating HMGA1-dependent invasiveness was elucidated by a specific PI3K inhibitor (LY294002) and constitutively active and dominant-negative Akt adenoviral constructs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	AKT serine/threonine kinase 1	Homo sapiens	49-52
16946303-5	2006	In addition, there was a decrease in the expression level of inhibitory apoptotic protein, XIAP, in the DLBCL cell lines sensitive to LY294002 after treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	X-linked inhibitor of apoptosis	Homo sapiens	91-95
17142776-7	2006	Furthermore, inhibition of PI3K by use of LY294002 reduces expression of IL-6 at both the mRNA and protein level in murine fibroblasts, and we suggest that PI3K is required for activation of PKCdelta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	interleukin 6	Mus musculus	73-77
17142776-7	2006	Furthermore, inhibition of PI3K by use of LY294002 reduces expression of IL-6 at both the mRNA and protein level in murine fibroblasts, and we suggest that PI3K is required for activation of PKCdelta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	protein kinase C, delta	Mus musculus	191-199
16949218-6	2006	In addition, the level of HCCR-1 was decreased by PI3K inhibitor, LY-294002, in a dose dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-75	BRI3 binding protein	Homo sapiens	26-32
17178855-8	2006	The role of phosphatidylinositol-3 kinase (PI3K)/Akt in mediating HMGA1-dependent invasiveness was elucidated by a specific PI3K inhibitor (LY294002) and constitutively active and dominant-negative Akt adenoviral constructs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	high mobility group AT-hook 1	Homo sapiens	66-71
16798728-8	2006	Inhibition of ERK1/2 and Akt activity by U-0126 and LY-294002, respectively, increased TNF-alpha-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-61	mitogen activated protein kinase 3	Rattus norvegicus	14-20
17113582-2	2006	We showed that TRAIL-induced apoptosis may be differentially regulated by inhibitors of MEK ERK (U0126) or PI3K/Akt (LY294002) pathway in TRAIL-sensitive (HT-29) and TRAIL-resistant (SW620) human epithelial colon cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	TNF superfamily member 10	Homo sapiens	15-20
17113582-2	2006	We showed that TRAIL-induced apoptosis may be differentially regulated by inhibitors of MEK ERK (U0126) or PI3K/Akt (LY294002) pathway in TRAIL-sensitive (HT-29) and TRAIL-resistant (SW620) human epithelial colon cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	112-115
17113582-2	2006	We showed that TRAIL-induced apoptosis may be differentially regulated by inhibitors of MEK ERK (U0126) or PI3K/Akt (LY294002) pathway in TRAIL-sensitive (HT-29) and TRAIL-resistant (SW620) human epithelial colon cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	TNF superfamily member 10	Homo sapiens	138-143
17113582-2	2006	We showed that TRAIL-induced apoptosis may be differentially regulated by inhibitors of MEK ERK (U0126) or PI3K/Akt (LY294002) pathway in TRAIL-sensitive (HT-29) and TRAIL-resistant (SW620) human epithelial colon cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	TNF superfamily member 10	Homo sapiens	138-143
17113582-3	2006	U0126 or LY294002 significantly enhanced TRAIL-induced apoptosis in HT-29 cells, but not in SW620 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	TNF superfamily member 10	Homo sapiens	41-46
16837650-7	2006	FBLN5 mRNA induction by TGF-beta was blocked by pretreatment with TGF-beta receptor inhibitor SB-431542, the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor LY-294002, and actinomycin D.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-171	fibulin 5	Homo sapiens	0-5
16837650-7	2006	FBLN5 mRNA induction by TGF-beta was blocked by pretreatment with TGF-beta receptor inhibitor SB-431542, the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor LY-294002, and actinomycin D.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-171	transforming growth factor beta 1	Homo sapiens	24-32
17052670-9	2006	PD98059 (an inhibitor of ERK) or LY294002 (an inhibitor of Akt), but not an inhibitor of p38 MAPK and JNK, significantly decreased cell viability and increased lactate dehydrogenase (LDH) release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Homo sapiens	59-62
16837650-8	2006	Basal and TGF-beta-induced FBLN5 hnRNA and mRNA were strongly and proportionally decreased by LY-294002, as was TGF-beta-induced phosphorylation of Akt, but not Smad3, as measured by Western blot analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-103	transforming growth factor beta 1	Homo sapiens	10-18
16837650-8	2006	Basal and TGF-beta-induced FBLN5 hnRNA and mRNA were strongly and proportionally decreased by LY-294002, as was TGF-beta-induced phosphorylation of Akt, but not Smad3, as measured by Western blot analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-103	fibulin 5	Homo sapiens	27-32
16798728-8	2006	Inhibition of ERK1/2 and Akt activity by U-0126 and LY-294002, respectively, increased TNF-alpha-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-61	AKT serine/threonine kinase 1	Rattus norvegicus	25-28
16798728-8	2006	Inhibition of ERK1/2 and Akt activity by U-0126 and LY-294002, respectively, increased TNF-alpha-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-61	tumor necrosis factor	Rattus norvegicus	87-96
16545819-5	2006	Cilostazol"s regulation of eNOS phosphorylation was reversed by protein kinase A inhibitor peptide (PKAI) and by LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	125-154
16848764-7	2006	MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK inhibitor U0126 and PI3K (phosphoinositide 3-kinase) inhibitor LY294002 also inhibited EGF-induced AQP3 expression and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	epidermal growth factor	Homo sapiens	188-191
16848764-7	2006	MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK inhibitor U0126 and PI3K (phosphoinositide 3-kinase) inhibitor LY294002 also inhibited EGF-induced AQP3 expression and cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	aquaporin 3 (Gill blood group)	Homo sapiens	200-204
16935846-4	2006	Either specific pharmacological PI3K and Akt inhibitors (LY294002, Akt I, and phosphoinositide analog-6) or Akt dominant-negative mutant (K179M) enhanced ERK-1/2 phosphorylation in unstimulated GH4C1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
17145871-5	2006	On the other hand, Akt, the pathway of which can up-regulate HIF-1alpha expression, was activated in the mouse lesions, whereas HIF-1alpha was markedly down-regulated in the mouse hepatocellular carcinoma (HCC) cell lines after treatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1alpha expression is dependent on PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	293-301	thymoma viral proto-oncogene 1	Mus musculus	19-22
17145871-5	2006	On the other hand, Akt, the pathway of which can up-regulate HIF-1alpha expression, was activated in the mouse lesions, whereas HIF-1alpha was markedly down-regulated in the mouse hepatocellular carcinoma (HCC) cell lines after treatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1alpha expression is dependent on PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	293-301	hypoxia inducible factor 1, alpha subunit	Mus musculus	128-138
17145871-5	2006	On the other hand, Akt, the pathway of which can up-regulate HIF-1alpha expression, was activated in the mouse lesions, whereas HIF-1alpha was markedly down-regulated in the mouse hepatocellular carcinoma (HCC) cell lines after treatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1alpha expression is dependent on PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	293-301	hypoxia inducible factor 1, alpha subunit	Mus musculus	128-138
17130464-6	2006	In cultured cell lines, insulin-mediated PRAS40 phosphorylation was prevented by the PI3K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	insulin	Homo sapiens	24-31
17130464-6	2006	In cultured cell lines, insulin-mediated PRAS40 phosphorylation was prevented by the PI3K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT1 substrate 1	Rattus norvegicus	41-47
17109063-6	2006	Pretreatment with 20 microM LY294002 (PI3K inhibitor) for 30 min inhibited phosphorylation of Akt, increased migration by activating Rac1 in polyamine-depleted IEC-6 cells, and restored the actin structure similar to that in cells grown in control medium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	94-97
17109063-6	2006	Pretreatment with 20 microM LY294002 (PI3K inhibitor) for 30 min inhibited phosphorylation of Akt, increased migration by activating Rac1 in polyamine-depleted IEC-6 cells, and restored the actin structure similar to that in cells grown in control medium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	Rac family small GTPase 1	Rattus norvegicus	133-137
16935846-4	2006	Either specific pharmacological PI3K and Akt inhibitors (LY294002, Akt I, and phosphoinositide analog-6) or Akt dominant-negative mutant (K179M) enhanced ERK-1/2 phosphorylation in unstimulated GH4C1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	mitogen activated protein kinase 3	Rattus norvegicus	154-161
16538228-9	2006	Phosphorylation of Akt and GSK3beta was prevented by LY294002, a PI3-K inhibitor, which facilitated subsequent DNA fragmentation 3 days after tGCI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
17093064-10	2006	In addition, Smad3 activation was stimulated by IGF-I and blocked by LY294002, suggesting cross-talk between Smad and the phosphatidylinositol-3 kinase/AKT pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	SMAD family member 3	Mus musculus	13-18
17093064-10	2006	In addition, Smad3 activation was stimulated by IGF-I and blocked by LY294002, suggesting cross-talk between Smad and the phosphatidylinositol-3 kinase/AKT pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	thymoma viral proto-oncogene 1	Mus musculus	152-155
16884765-6	2006	High concentrations of SDF-1alpha activated Akt and ERK1/2 pathways in both cell lines in a dose-dependent manner, which was primarily inhibited by LY294002 for pAkt and by PD98059 for pERK 1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Homo sapiens	44-47
16884765-6	2006	High concentrations of SDF-1alpha activated Akt and ERK1/2 pathways in both cell lines in a dose-dependent manner, which was primarily inhibited by LY294002 for pAkt and by PD98059 for pERK 1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	mitogen-activated protein kinase 3	Homo sapiens	52-58
16941482-4	2006	The decrease in P-MARCKS induced by IGF-I was blocked by pretreatment of cells with phosphoinositide 3-kinase (PI3K) inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	myristoylated alanine rich protein kinase C substrate	Homo sapiens	16-24
16538228-9	2006	Phosphorylation of Akt and GSK3beta was prevented by LY294002, a PI3-K inhibitor, which facilitated subsequent DNA fragmentation 3 days after tGCI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	glycogen synthase kinase 3 beta	Rattus norvegicus	27-35
16941482-4	2006	The decrease in P-MARCKS induced by IGF-I was blocked by pretreatment of cells with phosphoinositide 3-kinase (PI3K) inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	insulin like growth factor 1	Homo sapiens	36-41
17170229-4	2006	Inhibition of phosphoinositide-3kinase by LY294002 further increased the effect of Ang II on p27(kip) induction, whilst PKCs inhibition by GF109203X decreased such effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	angiotensinogen	Rattus norvegicus	83-89
17170229-4	2006	Inhibition of phosphoinositide-3kinase by LY294002 further increased the effect of Ang II on p27(kip) induction, whilst PKCs inhibition by GF109203X decreased such effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	93-96
16940331-3	2006	Freshly isolated cells present basal Akt phosphorylation, which is PI-3K-dependent, as incubation with the PI-3K inhibitor LY294002 decreased Ser-473 and Thr-308 phosphorylation in most samples analyzed (seven out of 10).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	AKT serine/threonine kinase 1	Homo sapiens	37-40
16933034-10	2006	PI3K inhibitors Wortmanin and LY294002, both increase tyr-phosphorylation of IRS-4, either in the presence of Ins alone or combined with Ang II.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	insulin receptor substrate 4	Rattus norvegicus	77-82
16933034-10	2006	PI3K inhibitors Wortmanin and LY294002, both increase tyr-phosphorylation of IRS-4, either in the presence of Ins alone or combined with Ang II.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	angiotensinogen	Rattus norvegicus	137-143
16972255-9	2006	Treatment with the phosphatidylinositol 3-kinase inhibitors, LY294002 or wortmannin, downregulated basal and UVB-induced MMP-1 and -3 secretions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	matrix metallopeptidase 1	Homo sapiens	121-133
17146391-9	2006	Interestingly, pharmacologic inhibition of the PI3 K signaling pathway by LY294002 resulted in strong down-regulation of the IL-1beta-induced expressions of iNOS protein and mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	interleukin 1 beta	Homo sapiens	125-133
17146391-9	2006	Interestingly, pharmacologic inhibition of the PI3 K signaling pathway by LY294002 resulted in strong down-regulation of the IL-1beta-induced expressions of iNOS protein and mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	inositol-3-phosphate synthase 1	Homo sapiens	157-161
16945991-6	2006	IL-6-mediated glucose metabolism was suppressed, but lipid metabolism was unaltered, by inhibition of PI3-kinase with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	interleukin 6	Homo sapiens	0-4
17013836-4	2006	Inhibition of PI3 kinase (PI3K) by Ly294002 in mouse HCC cells in vitro suppressed the nuclear shift of cyclin D1 as well as cell proliferation, while PI3K activation by PTEN suppression failed to induce nuclear shift of cyclin D1, suggesting that PI3K activation is essential but not sufficient for the cyclin D1 nuclear shift.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	14-24
17013836-4	2006	Inhibition of PI3 kinase (PI3K) by Ly294002 in mouse HCC cells in vitro suppressed the nuclear shift of cyclin D1 as well as cell proliferation, while PI3K activation by PTEN suppression failed to induce nuclear shift of cyclin D1, suggesting that PI3K activation is essential but not sufficient for the cyclin D1 nuclear shift.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	cyclin D1	Mus musculus	104-113
17188151-5	2006	RESULTS: Treatment of TT cells with LY294002 significantly suppressed levels of phospho-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	88-91
16973299-8	2006	Intracerebral infusion of LY294002 before IPC reverses the increase in Akt phosphorylation and the decrease in JNK signaling activation, as well as the neuroprotective action of IPC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Rattus norvegicus	71-74
16973299-8	2006	Intracerebral infusion of LY294002 before IPC reverses the increase in Akt phosphorylation and the decrease in JNK signaling activation, as well as the neuroprotective action of IPC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	mitogen-activated protein kinase 8	Rattus norvegicus	111-114
17135405-6	2006	Intravitreous injections of pharmacological ERK-1/2 (PD98059) or Akt (LY294002) inhibitors showed that VEGF exerts neuroprotection by dual activation of ERK-1/2 and Akt pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	vascular endothelial growth factor A	Homo sapiens	103-107
16963453-2	2006	Also, the activation of Rap1 was blocked by PP1, SU6656, LY294002, GF109203X, or BAPTA-AM, which indicates that the downstream signaling events in Rap1 activation involve Src tyrosine kinases, phosphoinositide 3-kinase, protein kinase C, and release of calcium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	RAP1A, member of RAS oncogene family	Homo sapiens	24-28
17068290-6	2006	The proliferative effect of C-peptide on VSMCs was inhibited by Src short interference RNA transfection, PP2, an inhibitor of Src-kinase, LY294002, an inhibitor of PI-3 kinase, and the ERK1/2 inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	insulin	Homo sapiens	28-37
16963453-2	2006	Also, the activation of Rap1 was blocked by PP1, SU6656, LY294002, GF109203X, or BAPTA-AM, which indicates that the downstream signaling events in Rap1 activation involve Src tyrosine kinases, phosphoinositide 3-kinase, protein kinase C, and release of calcium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	inorganic pyrophosphatase 1	Homo sapiens	44-47
16963453-2	2006	Also, the activation of Rap1 was blocked by PP1, SU6656, LY294002, GF109203X, or BAPTA-AM, which indicates that the downstream signaling events in Rap1 activation involve Src tyrosine kinases, phosphoinositide 3-kinase, protein kinase C, and release of calcium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	RAP1A, member of RAS oncogene family	Homo sapiens	147-151
16732316-8	2006	Furthermore, phosphatidylinositol 3-kinase (PI3K)/Akt chemical inhibitors LY294002 and wortmannin suppressed radiation-induced MMP-9 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	13-42
16732316-8	2006	Furthermore, phosphatidylinositol 3-kinase (PI3K)/Akt chemical inhibitors LY294002 and wortmannin suppressed radiation-induced MMP-9 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	50-53
16732316-8	2006	Furthermore, phosphatidylinositol 3-kinase (PI3K)/Akt chemical inhibitors LY294002 and wortmannin suppressed radiation-induced MMP-9 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	matrix metallopeptidase 9	Homo sapiens	127-132
16790501-9	2006	The PI3K inhibitor LY-294002, and Akt small interfering RNA inhibited Akt activation and Hsp70 expression in HEMEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	AKT serine/threonine kinase 1	Homo sapiens	70-73
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	36-40
17046572-9	2006	We also observed that inhibition of stromal cell mammalian target of rapamycin with rapamycin, or phosphatidylinositol 3 kinase with LY294002, resulted in inhibition of stromal cell MMP-2 protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	matrix metallopeptidase 2	Homo sapiens	182-187
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	tumor necrosis factor	Homo sapiens	80-89
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	C-C motif chemokine ligand 2	Homo sapiens	107-147
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	C-C motif chemokine ligand 2	Homo sapiens	161-165
16782756-9	2006	Inhibition of phosphatidylinositol 3-kinase (PI3K) activation by LY294002 in mtALDH-A549 cells significantly increased necrotic cell death after hyperoxic exposure, indicating that PI3K-Akt activation by mtALDH played an important role in cell survival after hyperoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	186-189
16982054-6	2006	Treatment of mouse aortic rings and SVEC 4-10 cells with LY294002, but not SB203580, PD098059 or U0126, abolished HIMF-induced vascular sprouting and angiogenic responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	resistin like alpha	Mus musculus	114-118
16883576-4	2006	In this study, we have shown that the phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, and the mammalian target of rapamycin (mTOR) inhibitor, rapamycin, have similar effects on the inhibition of HDM2 phosphorylation and protein turnover.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	MDM2 proto-oncogene	Homo sapiens	205-209
16563718-7	2006	Furthermore, inhibition of ERK activity by PD98059 and PI3K/Akt activity by LY294002 or wortmannin significantly reduced the LA-induced activation of nuclear factor kappa B (NF-kappaB).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	60-63
16563718-7	2006	Furthermore, inhibition of ERK activity by PD98059 and PI3K/Akt activity by LY294002 or wortmannin significantly reduced the LA-induced activation of nuclear factor kappa B (NF-kappaB).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	nuclear factor kappa B subunit 1	Homo sapiens	150-172
16563718-7	2006	Furthermore, inhibition of ERK activity by PD98059 and PI3K/Akt activity by LY294002 or wortmannin significantly reduced the LA-induced activation of nuclear factor kappa B (NF-kappaB).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	nuclear factor kappa B subunit 1	Homo sapiens	174-183
16563718-9	2006	Indeed, LA-mediated gene expression of the vascular cell adhesion molecule 1 was suppressed by PD98059, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	vascular cell adhesion molecule 1	Homo sapiens	43-76
16911581-4	2006	This effect was mediated through both the MAPK and PI3-kinase signaling pathways, as shown by the ability of the specific inhibitors UO126 and LY294002 to abrogate IGF-I action.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	insulin-like growth factor 1	Rattus norvegicus	164-169
17007883-9	2006	This inductive effect was abolished while phosphatidylinositol 3-kinase (PI3K) pathway was blocked by the PI3K inhibitor LY294002 and Wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	42-71
16920823-7	2006	The phosphatidylinositol 3-kinase inhibitor LY294002 reduced beta-catenin expression in Tax-positive T-cell lines, and inactivation of glycogen synthase kinase 3beta by lithium chloride restored beta-catenin expression in Tax-negative T-cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	catenin beta 1	Homo sapiens	61-73
16920823-7	2006	The phosphatidylinositol 3-kinase inhibitor LY294002 reduced beta-catenin expression in Tax-positive T-cell lines, and inactivation of glycogen synthase kinase 3beta by lithium chloride restored beta-catenin expression in Tax-negative T-cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	catenin beta 1	Homo sapiens	195-207
16412560-5	2006	LY294002 treatment resulted in Smad2 accumulation in the nuclei and an increased Smad binding element (SBE)-luciferase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	SMAD family member 2	Homo sapiens	31-36
17072262-12	2006	The specific PI (3)-K inhibitors LY294002 and wortmannin blocked leptin-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	leptin	Homo sapiens	65-71
17167531-7	2006	Moreover, we found that PIMT expression returned to the basal level when cells were replated on a substratum after detachment, though downregulation of PIMT expression could be partly prevented by the PI3K inhibitors LY294002 and wortmannin, as well as by the proteasome inhibitors MG-132, lactacystin, and beta-lactone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Bos taurus	24-28
16973122-3	2006	Cu2+- and Zn2+-induced phosphorylation of Akt was blocked by phosphoinositide 3-kinase (PI3K) inhibitors, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	AKT serine/threonine kinase 1	Homo sapiens	42-45
16945353-8	2006	Conversely, LY294002, an inhibitor of Akt upstream molecule PI3-kinase, enhanced 6-OHDA-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	38-41
16959214-5	2006	It would seem that this increase in VEGFR-3 occurred via the ERK and mTOR pathways, since their respective inhibitors U0126, LY294002 or rapamycin were responsible for a decrease of VEGFR-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	fms related receptor tyrosine kinase 4	Homo sapiens	36-43
16959214-5	2006	It would seem that this increase in VEGFR-3 occurred via the ERK and mTOR pathways, since their respective inhibitors U0126, LY294002 or rapamycin were responsible for a decrease of VEGFR-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	mitogen-activated protein kinase 1	Homo sapiens	61-64
16959214-5	2006	It would seem that this increase in VEGFR-3 occurred via the ERK and mTOR pathways, since their respective inhibitors U0126, LY294002 or rapamycin were responsible for a decrease of VEGFR-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	fms related receptor tyrosine kinase 4	Homo sapiens	182-189
16709959-11	2006	A dominant-negative mutant of PI-3K, Deltap85, as well as PI-3K inhibitor, LY294002, also blocked HIMF-induced NF-kappaB activation and attenuated VCAM-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	resistin like alpha	Mus musculus	98-102
16709959-11	2006	A dominant-negative mutant of PI-3K, Deltap85, as well as PI-3K inhibitor, LY294002, also blocked HIMF-induced NF-kappaB activation and attenuated VCAM-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	vascular cell adhesion molecule 1	Mus musculus	147-153
16709959-12	2006	Furthermore, LY294002 pretreatment abolished HIMF-enhanced mononuclear cells adhesion to endothelial and epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	resistin like alpha	Mus musculus	45-49
16715521-5	2006	Inhibition of PI3-kinase activity with the chemical inhibitor LY294002 blocked PEMF-dependent activation of mTOR in both the pre-osteoblast and fibroblast cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	14-17
16715521-5	2006	Inhibition of PI3-kinase activity with the chemical inhibitor LY294002 blocked PEMF-dependent activation of mTOR in both the pre-osteoblast and fibroblast cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	mechanistic target of rapamycin kinase	Mus musculus	108-112
17167531-7	2006	Moreover, we found that PIMT expression returned to the basal level when cells were replated on a substratum after detachment, though downregulation of PIMT expression could be partly prevented by the PI3K inhibitors LY294002 and wortmannin, as well as by the proteasome inhibitors MG-132, lactacystin, and beta-lactone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-225	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Bos taurus	152-156
16962933-7	2006	Pretreatment of cells with LY294002, a pharmacologic inhibitor of PI3K or transfection with the kinase-dead mutant Akt abrogated the SIN-1-induced Nrf2 activation and HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	147-151
16984382-5	2006	Downregulation of constitutively active Akt by PI3K inhibitors, wortmannin and LY294002, reversed cellular resistance to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	40-43
16984382-5	2006	Downregulation of constitutively active Akt by PI3K inhibitors, wortmannin and LY294002, reversed cellular resistance to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	TNF superfamily member 10	Homo sapiens	121-126
16955211-4	2006	effect of specific inhibitors of PI(3)K (LY294002 and wortmannin) and MAPK (PD98059 and UO126) on the insulin-mediated reduction of ghrelin levels in rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	ghrelin and obestatin prepropeptide	Rattus norvegicus	132-139
17018612-7	2006	Treatment of CD9(-) parent cells with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, inhibited process outgrowth and survival, suggesting that PI3K/Akt signaling is required for the morphologic change and cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	CD9 molecule	Homo sapiens	13-16
17018612-7	2006	Treatment of CD9(-) parent cells with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, inhibited process outgrowth and survival, suggesting that PI3K/Akt signaling is required for the morphologic change and cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	40-69
17018612-7	2006	Treatment of CD9(-) parent cells with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, inhibited process outgrowth and survival, suggesting that PI3K/Akt signaling is required for the morphologic change and cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Homo sapiens	161-164
17018612-8	2006	Production of matrix metalloproteinase (MMP)-2 was likewise suppressed in the CD9 transfectants and in LY294002-treated parent cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	matrix metallopeptidase 2	Homo sapiens	14-46
16962933-7	2006	Pretreatment of cells with LY294002, a pharmacologic inhibitor of PI3K or transfection with the kinase-dead mutant Akt abrogated the SIN-1-induced Nrf2 activation and HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	heme oxygenase 1	Rattus norvegicus	167-171
17003457-2	2006	METHODS: Cultured human RPE cells were pretreated with medium alone, with LY294002 (LY), an inhibitor of phosphatidylinositol-3 kinase (PI3K) and its downstream effector Akt, or with Akt/protein kinase B signaling inhibitor (API)-2, a specific Akt inhibitor, and then were stimulated with H2O2 at different doses for various times.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Homo sapiens	170-173
16924472-7	2006	TSP-1 production by TEC was enhanced by the treatment with LY294002 and wortmannin and with rapamycin, suggesting a negative regulation of TSP-1 expression by the PI3K/Akt/mTOR pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	thrombospondin 1	Homo sapiens	0-5
16982883-6	2006	The effect of LY294002 was specific to survival, because treatment of BMM with LY294002 affected CpG DNA-induced TNF-alpha production only modestly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	tumor necrosis factor	Mus musculus	113-122
16982883-6	2006	The effect of LY294002 was specific to survival, because treatment of BMM with LY294002 affected CpG DNA-induced TNF-alpha production only modestly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	tumor necrosis factor	Mus musculus	113-122
16987252-6	2006	In our hands, activated PI-3-K reduced the stability of c-Myc, because (i) the PI-3-K inhibitor, LY294002, prevented the reduction in c-Myc levels induced by MPEP; and (ii) over-expression of AKT promoted c-Myc ubiquitination.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	thymoma viral proto-oncogene 1	Mus musculus	192-195
16953813-3	2006	OBJECTIVES: The purpose of this study was to investigate the caseinolytic activity in human osteosarcoma cell line U2OS cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of p38 inhibitor SB203580, mitogen-activated protein kinase kinase (MEK) inhibitor U0126, and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	369-377	interleukin 1 alpha	Homo sapiens	142-160
17029596-7	2006	Prevention of rotenone-induced apoptosis by NGF was attenuated by the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor, LY294002, but not MAPK kinase (MEK) inhibitors, PD98059 or U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	nerve growth factor	Rattus norvegicus	44-47
16953813-3	2006	OBJECTIVES: The purpose of this study was to investigate the caseinolytic activity in human osteosarcoma cell line U2OS cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of p38 inhibitor SB203580, mitogen-activated protein kinase kinase (MEK) inhibitor U0126, and phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	369-377	interleukin 1 alpha	Homo sapiens	162-171
16953813-8	2006	From the results of casein zymography and ELISA, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha or P. gingivalis-stimulated t-PA production, respectively (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	interleukin 1 alpha	Homo sapiens	105-114
16953813-8	2006	From the results of casein zymography and ELISA, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha or P. gingivalis-stimulated t-PA production, respectively (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	plasminogen activator, tissue type	Homo sapiens	143-147
16953813-10	2006	SB203580, U0126, and LY294002 suppress t-PA production and/or activity and may therefore be valuable therapeutics in t-PA-mediated periodontal destruction, and might be proved clinically useful agents, in combination with standard treatment modalities, in the treatment of periodontitis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	plasminogen activator, tissue type	Homo sapiens	39-43
16964427-11	2006	Further, we found that PI3K inhibitors, LY294002 and Wortmannin, inhibited HIF-1alpha and VEGF expression induced by UV radiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-85
16953813-10	2006	SB203580, U0126, and LY294002 suppress t-PA production and/or activity and may therefore be valuable therapeutics in t-PA-mediated periodontal destruction, and might be proved clinically useful agents, in combination with standard treatment modalities, in the treatment of periodontitis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	plasminogen activator, tissue type	Homo sapiens	117-121
16964427-11	2006	Further, we found that PI3K inhibitors, LY294002 and Wortmannin, inhibited HIF-1alpha and VEGF expression induced by UV radiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	vascular endothelial growth factor A	Homo sapiens	90-94
17013094-3	2006	Autotaxin induced uPA expression in a dose-dependent manner that was inhibited by pharmacological inhibitors for Gi (pertussis toxin), phosphoinositide 3-kinase (PI3K, LY294002), Akt inhibitor (AktI), proteosome activity and IkappaB phosphorylation (pyrrolidine dithiocarbamate), and by a dominant negative mutant (DN) of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	0-9
17013094-3	2006	Autotaxin induced uPA expression in a dose-dependent manner that was inhibited by pharmacological inhibitors for Gi (pertussis toxin), phosphoinositide 3-kinase (PI3K, LY294002), Akt inhibitor (AktI), proteosome activity and IkappaB phosphorylation (pyrrolidine dithiocarbamate), and by a dominant negative mutant (DN) of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	plasminogen activator, urokinase	Homo sapiens	18-21
16864584-5	2006	However, serum removal or blockade of PI3K signaling by LY294002 transiently stimulated basal Krox-24 expression and increased CB1-mediated induction of Krox-24.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	early growth response 1	Mus musculus	94-101
16740654-7	2006	Although granulosa cell apoptosis induced by ceramide was attenuated by the presence of GDF-9, this protective effect of GDF-9 was prevented by the phosphatidylinositol 3-kinase inhibitor LY294002 and a dominant negative form of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	growth differentiation factor 9	Homo sapiens	121-126
16940243-10	2006	IGF-1-induced increase in alpha-sma expression and type-I collagen was significantly inhibited by pretreatment with LY294002 and IGF-1 receptor antibody.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	insulin like growth factor 1	Homo sapiens	0-5
16864584-5	2006	However, serum removal or blockade of PI3K signaling by LY294002 transiently stimulated basal Krox-24 expression and increased CB1-mediated induction of Krox-24.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	cannabinoid receptor 1 (brain)	Mus musculus	127-130
16864584-5	2006	However, serum removal or blockade of PI3K signaling by LY294002 transiently stimulated basal Krox-24 expression and increased CB1-mediated induction of Krox-24.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	early growth response 1	Mus musculus	153-160
16682955-7	2006	This may reflect both inhibition of PI-3 kinase pathways and mammalian target of rapamycin (mTOR)-dependent signaling, as the phosphorylation of Thr389 site was sensitive to treatment with the PI3-K and mTOR inhibitors, LY294002 and rapamycin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	mechanistic target of rapamycin kinase	Homo sapiens	61-90
16682955-7	2006	This may reflect both inhibition of PI-3 kinase pathways and mammalian target of rapamycin (mTOR)-dependent signaling, as the phosphorylation of Thr389 site was sensitive to treatment with the PI3-K and mTOR inhibitors, LY294002 and rapamycin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	mechanistic target of rapamycin kinase	Homo sapiens	92-96
16682955-7	2006	This may reflect both inhibition of PI-3 kinase pathways and mammalian target of rapamycin (mTOR)-dependent signaling, as the phosphorylation of Thr389 site was sensitive to treatment with the PI3-K and mTOR inhibitors, LY294002 and rapamycin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	mechanistic target of rapamycin kinase	Homo sapiens	203-207
16847434-8	2006	Protection was blocked by either LY294002 or UO126, inhibitors of Akt and p44/42 MAPK, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	mitogen activated protein kinase 3	Rattus norvegicus	74-77
16870142-4	2006	Insulin suppressed angptl4 mRNA expression in time- and dose-dependent manners, and the inhibitory effect was attenuated by a RNA synthesis inhibitor actinomycin D and a phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	insulin	Homo sapiens	0-7
16870142-4	2006	Insulin suppressed angptl4 mRNA expression in time- and dose-dependent manners, and the inhibitory effect was attenuated by a RNA synthesis inhibitor actinomycin D and a phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	angiopoietin like 4	Homo sapiens	19-26
16870142-4	2006	Insulin suppressed angptl4 mRNA expression in time- and dose-dependent manners, and the inhibitory effect was attenuated by a RNA synthesis inhibitor actinomycin D and a phosphoinositide 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	170-195
16794223-3	2006	METHODS AND RESULTS: SR-BI-dependent HDL selective cholesterol ester uptake in human HepG2 hepatoma cells was decreased (approximately 50%) by the PI3K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	scavenger receptor class B member 1	Homo sapiens	21-26
16966610-6	2006	The activation of Akt and eNOS by T3 was abolished by the PI3-kinase inhibitors, LY294002 and wortmannin, but not by the transcriptional inhibitor, actinomycin D.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	thymoma viral proto-oncogene 1	Mus musculus	18-21
16905201-5	2006	The modulation of PI3K/Akt activation by treatment of LY294002 or expression of Akt mutants such as Akt-DN or Myr-Akt exerted a significant effect on the activation of ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	thymoma viral proto-oncogene 1	Mus musculus	23-26
16905201-5	2006	The modulation of PI3K/Akt activation by treatment of LY294002 or expression of Akt mutants such as Akt-DN or Myr-Akt exerted a significant effect on the activation of ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	mitogen-activated protein kinase 3	Mus musculus	168-174
16939811-5	2006	Rapamycin and LY294002 suppressed pS6 in 10 of 11 cases that showed increased basal levels, consistent with phosphatidylinositol 3 (PI3)-kinase/Akt/mTOR signaling being the predominant upstream signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	taste 2 receptor member 63 pseudogene	Homo sapiens	34-37
16571650-9	2006	Finally, treatment of cell lines with the PI3K inhibitor LY294002 caused a reduction in expression of OPN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	secreted phosphoprotein 1	Homo sapiens	102-105
16740979-7	2006	Neither SB203580 nor LY294002 changed the E2-increased levels of resistin mRNA, but they respectively inhibited E2-stimulated phosphorylation of p38 MAPK and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	158-161
16916320-7	2006	Interestingly, when phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling was blocked simultaneously by either LY294002 or rapamycin, growth inhibition mediated by SU11248 was potentiated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	50-53
16916320-7	2006	Interestingly, when phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling was blocked simultaneously by either LY294002 or rapamycin, growth inhibition mediated by SU11248 was potentiated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	mechanistic target of rapamycin kinase	Homo sapiens	54-83
16939811-5	2006	Rapamycin and LY294002 suppressed pS6 in 10 of 11 cases that showed increased basal levels, consistent with phosphatidylinositol 3 (PI3)-kinase/Akt/mTOR signaling being the predominant upstream signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	mechanistic target of rapamycin kinase	Homo sapiens	148-152
16981137-5	2006	The phosphorylation of Akt induced by TNF-alpha was markedly attenuated by LY294002 and wortmannin, inhibitors of PI3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	thymoma viral proto-oncogene 1	Mus musculus	23-26
16865270-7	2006	Phosphorylation of Akt was inhibited by CoCl(2) treatment and LY294002 treatment inhibited HIF-1alpha expression in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	AKT serine/threonine kinase 1	Homo sapiens	19-22
16865270-7	2006	Phosphorylation of Akt was inhibited by CoCl(2) treatment and LY294002 treatment inhibited HIF-1alpha expression in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
16598748-7	2006	LY294002, a PI3-kinase inhibitor, blocked the TGF-beta-induced amino acid uptake only partially, but completely blocked TGF-beta-induced Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transforming growth factor beta 1	Homo sapiens	46-54
16598748-7	2006	LY294002, a PI3-kinase inhibitor, blocked the TGF-beta-induced amino acid uptake only partially, but completely blocked TGF-beta-induced Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transforming growth factor beta 1	Homo sapiens	120-128
16598748-7	2006	LY294002, a PI3-kinase inhibitor, blocked the TGF-beta-induced amino acid uptake only partially, but completely blocked TGF-beta-induced Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	137-140
16598748-8	2006	Moreover, the level of phospho-Smad3 was found to be high even when LY294002 blocked TGF-beta-induced phospho-Akt levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	transforming growth factor beta 1	Homo sapiens	85-93
16598748-8	2006	Moreover, the level of phospho-Smad3 was found to be high even when LY294002 blocked TGF-beta-induced phospho-Akt levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	110-113
16885413-4	2006	Inhibition of PI3K with LY294002 prevented EGF-induced increases in GAPDH and pax2 abundance in NRK-52E renal tubular cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	68-73
16885413-4	2006	Inhibition of PI3K with LY294002 prevented EGF-induced increases in GAPDH and pax2 abundance in NRK-52E renal tubular cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	paired box 2	Rattus norvegicus	78-82
16741926-7	2006	Pretreatment of diaphragm with PI3K inhibitor LY294002 blocked the activation of Akt in normal and mdx mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	thymoma viral proto-oncogene 1	Mus musculus	81-84
16741926-9	2006	Treatment of diaphragm muscle with LY294002 inhibited the stretch-induced activation of IkappaB (IkappaB) kinase (IKK) and NF-kappaB transcription factor in normal and mdx mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132
16981137-5	2006	The phosphorylation of Akt induced by TNF-alpha was markedly attenuated by LY294002 and wortmannin, inhibitors of PI3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	tumor necrosis factor	Mus musculus	38-47
16981137-6	2006	Wortmannin and LY294002 significantly reduce the TNF-alpha-induced IL-6 synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	tumor necrosis factor	Mus musculus	49-58
16981137-6	2006	Wortmannin and LY294002 significantly reduce the TNF-alpha-induced IL-6 synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 6	Mus musculus	67-71
16800849-5	2006	Interestingly, the survival-promoting effect of tPA was blocked by the phosphatidylinositol-3 (PI-3) kinase inhibitor, LY294002, but not by the mitogen-activated protein (MAP) kinase inhibitor, U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	plasminogen activator, tissue type	Homo sapiens	48-51
16981137-7	2006	On the contrary, the suppressive effects of Akt inhibitor, wortmannin or LY294002 on TNF-alpha-induced phosphorylation of p44/p42 MAP kinase were minor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	tumor necrosis factor	Mus musculus	85-94
16981137-7	2006	On the contrary, the suppressive effects of Akt inhibitor, wortmannin or LY294002 on TNF-alpha-induced phosphorylation of p44/p42 MAP kinase were minor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	mitogen-activated protein kinase 3	Mus musculus	122-125
16981137-7	2006	On the contrary, the suppressive effects of Akt inhibitor, wortmannin or LY294002 on TNF-alpha-induced phosphorylation of p44/p42 MAP kinase were minor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	cyclin-dependent kinase 20	Mus musculus	126-129
16517941-5	2006	LY-294002 (a PI3-K inhibitor) diminished the increases in contractile responses in ANG II-incubated aortas and aortas from chronic insulin-treated diabetic rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	angiotensinogen	Rattus norvegicus	83-89
16798746-6	2006	Raloxifene also induced the phosphorylation of Akt, and pretreatment with a phosphatidylinositol 3-kinase inhibitor, LY294002, significantly attenuated the raloxifene-induced telomerase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	47-50
16762504-6	2006	However, LY294002 could reverse the effect of sodium orthovanadate on the phosphorylation of ASK1 at threonine 845, namely, sodium orthovanadate inhibited ASK1 through the PI3-K/Akt-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	93-97
16762504-6	2006	However, LY294002 could reverse the effect of sodium orthovanadate on the phosphorylation of ASK1 at threonine 845, namely, sodium orthovanadate inhibited ASK1 through the PI3-K/Akt-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	155-159
16762504-6	2006	However, LY294002 could reverse the effect of sodium orthovanadate on the phosphorylation of ASK1 at threonine 845, namely, sodium orthovanadate inhibited ASK1 through the PI3-K/Akt-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Rattus norvegicus	178-181
16806309-6	2006	Treating cells with either wortmannin or LY294002, two structurally different inhibitors of phosphatidylinositol 3-kinase (PI3K) and with phospholipase C (PLC) inhibitor U73122, abolished the beta-BuTx-induced facilitation of synaptic transmission.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	92-121
16518842-11	2006	The PI3K inhibitor LY294002 and the MEK inhibitor PD98059 caused a partial inhibition of the Ras-induced ErbB4 receptor phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	erb-b2 receptor tyrosine kinase 4	Homo sapiens	105-110
16870179-5	2006	CpG ODN induced the phosphorylation of Akt, and the inhibition of Akt by LY294002 suppressed CpG ODN-induced TNF-alpha, TNFR-II, and MMP-9 expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Homo sapiens	66-69
16870179-5	2006	CpG ODN induced the phosphorylation of Akt, and the inhibition of Akt by LY294002 suppressed CpG ODN-induced TNF-alpha, TNFR-II, and MMP-9 expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	tumor necrosis factor	Homo sapiens	109-118
16870179-5	2006	CpG ODN induced the phosphorylation of Akt, and the inhibition of Akt by LY294002 suppressed CpG ODN-induced TNF-alpha, TNFR-II, and MMP-9 expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	TNF receptor superfamily member 1B	Homo sapiens	120-127
16870179-5	2006	CpG ODN induced the phosphorylation of Akt, and the inhibition of Akt by LY294002 suppressed CpG ODN-induced TNF-alpha, TNFR-II, and MMP-9 expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	matrix metallopeptidase 9	Homo sapiens	133-138
16310342-8	2006	(5) LY294002 inhibited the TGF-beta1-induced gene expression and DNA binding activity of serum response factor (SRF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	transforming growth factor, beta 1	Mus musculus	27-36
16310342-8	2006	(5) LY294002 inhibited the TGF-beta1-induced gene expression and DNA binding activity of serum response factor (SRF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	serum response factor	Mus musculus	89-110
16310342-7	2006	(4) LY294002 and the Akt-specific siRNA inhibited the TGF-beta1-induced SM22alpha gene expression and promoter activity, suggesting that the TGF-beta1-induced gene expression was mediated by PI3K/Akt at the transcriptional level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	transforming growth factor, beta 1	Mus musculus	54-63
16310342-7	2006	(4) LY294002 and the Akt-specific siRNA inhibited the TGF-beta1-induced SM22alpha gene expression and promoter activity, suggesting that the TGF-beta1-induced gene expression was mediated by PI3K/Akt at the transcriptional level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	transgelin	Mus musculus	72-81
16310342-8	2006	(5) LY294002 inhibited the TGF-beta1-induced gene expression and DNA binding activity of serum response factor (SRF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	serum response factor	Mus musculus	112-115
16310342-7	2006	(4) LY294002 and the Akt-specific siRNA inhibited the TGF-beta1-induced SM22alpha gene expression and promoter activity, suggesting that the TGF-beta1-induced gene expression was mediated by PI3K/Akt at the transcriptional level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	transforming growth factor, beta 1	Mus musculus	141-150
16875492-8	2006	We show that the PI(3)K inhibitor, LY294002, partially inhibits the apoptotic response of the hepatocyte to IFNgamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	interferon gamma	Homo sapiens	108-116
16310342-7	2006	(4) LY294002 and the Akt-specific siRNA inhibited the TGF-beta1-induced SM22alpha gene expression and promoter activity, suggesting that the TGF-beta1-induced gene expression was mediated by PI3K/Akt at the transcriptional level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	thymoma viral proto-oncogene 1	Mus musculus	196-199
16882030-6	2006	Conversely, the PI3-kinase inhibitor, LY294002, enhanced gonococcal invasion of, and Akt activity within, primary cervical cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	85-88
16798838-4	2006	The tyrosine kinase inhibitor Tyrphostin A9, phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 as well as proteasome inhibitors significantly blocked the CXCL8-induced chemotaxis of L1.2 cells and human neutrophils.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	C-X-C motif chemokine ligand 8	Homo sapiens	160-165
16798838-9	2006	The CXCL8-induced phosphorylation of Cbl was also reduced when cells were pre-treated with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	C-X-C motif chemokine ligand 8	Homo sapiens	4-9
16798838-9	2006	The CXCL8-induced phosphorylation of Cbl was also reduced when cells were pre-treated with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	Cbl proto-oncogene	Homo sapiens	37-40
16790529-7	2006	Addition of the PI-3 kinase inhibitor LY294002 abrogated this response; moreover, addition of the Akt/PKB inhibitor interleukin (IL)-6-hydroxymethyl-chiro-inositol-2(R)-2-methyl-3-O-octadecylcarbonate prevented p27(Kip-1) phosphorylation in response to CTGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	interferon alpha inducible protein 27	Homo sapiens	211-214
16790529-7	2006	Addition of the PI-3 kinase inhibitor LY294002 abrogated this response; moreover, addition of the Akt/PKB inhibitor interleukin (IL)-6-hydroxymethyl-chiro-inositol-2(R)-2-methyl-3-O-octadecylcarbonate prevented p27(Kip-1) phosphorylation in response to CTGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	cyclin dependent kinase inhibitor 1B	Homo sapiens	215-220
16790529-7	2006	Addition of the PI-3 kinase inhibitor LY294002 abrogated this response; moreover, addition of the Akt/PKB inhibitor interleukin (IL)-6-hydroxymethyl-chiro-inositol-2(R)-2-methyl-3-O-octadecylcarbonate prevented p27(Kip-1) phosphorylation in response to CTGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	cellular communication network factor 2	Homo sapiens	253-257
16788844-6	2006	RESULTS: The culture of SiHa cells in the presence of 50 microg/1.5 ml fibronectin led to expression of pro-MMP-9 and activation of MMP-2 within 2 h. When cells were treated with ERK inhibitor (PD98059) and grown in the presence of fibronectin MMP-2 activation was partially inhibited, but when cells were treated with PI-3K inhibitor (LY294002) and grown in the presence of fibronectin MMP-2 activation was appreciably reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	336-344	fibronectin 1	Homo sapiens	71-82
16514645-6	2006	The sphingosine 1-phosphate-induced HSP27 levels were attenuated by LY294002 or wortmannin, PI3K inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	heat shock protein 1	Mus musculus	36-41
16788844-6	2006	RESULTS: The culture of SiHa cells in the presence of 50 microg/1.5 ml fibronectin led to expression of pro-MMP-9 and activation of MMP-2 within 2 h. When cells were treated with ERK inhibitor (PD98059) and grown in the presence of fibronectin MMP-2 activation was partially inhibited, but when cells were treated with PI-3K inhibitor (LY294002) and grown in the presence of fibronectin MMP-2 activation was appreciably reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	336-344	mitogen-activated protein kinase 1	Homo sapiens	179-182
16527514-3	2006	We found that both PI 3-K inhibitors, wortmannin and LY294002, markedly suppressed the phosphorylation of Akt and accelerated Fas-mediated apoptosis in OSCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	106-109
16845323-10	2006	Epo increased Akt kinase activity, which was abrogated by co-treatment with LY294002, a specific blocker of phosphoinositide 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	erythropoietin	Homo sapiens	0-3
16845323-10	2006	Epo increased Akt kinase activity, which was abrogated by co-treatment with LY294002, a specific blocker of phosphoinositide 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	14-17
16845323-11	2006	LY294002 also inhibited the cytoprotective effects of Epo in melanoma cells under both normoxic and hypoxic conditions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	erythropoietin	Homo sapiens	54-57
16794215-11	2006	LY294002 reduced Akt and GSK3beta phosphorylation and increased brain injury after SAH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	17-20
16621593-5	2006	The mitogenic effect of OA was significantly reduced by pretreatment of LY294002 (5 microM) or wortmannin (1 microM), potent, and specific inhibitors of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	153-182
16621593-7	2006	OA-induced activation of Akt/PKB was inhibited by either LY294002 or wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Rattus norvegicus	25-32
16794215-11	2006	LY294002 reduced Akt and GSK3beta phosphorylation and increased brain injury after SAH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	25-33
16750184-7	2006	RESULTS: Inhibition of PI 3-kinase by Ly294002 or wortmannin, two inhibitors, decreased formation of ROS, phosphorylation of p38 MAPK, and TGFbeta expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	mitogen-activated protein kinase 14	Homo sapiens	125-128
17172126-8	2006	BDNF-stimulated NO production was blocked by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	brain derived neurotrophic factor	Mus musculus	0-4
17172126-9	2006	In vitro, BDNF induced HUVEC migration and tube formation on Matrigel, which could be significantly blocked by LY294002 and N(G)-nitro-L-arginine methyl ester (L-NAME) respectively; but BDNF induced HUVEC apoptosis could be blocked only by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	brain derived neurotrophic factor	Mus musculus	10-14
17172126-9	2006	In vitro, BDNF induced HUVEC migration and tube formation on Matrigel, which could be significantly blocked by LY294002 and N(G)-nitro-L-arginine methyl ester (L-NAME) respectively; but BDNF induced HUVEC apoptosis could be blocked only by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	brain derived neurotrophic factor	Mus musculus	186-190
17172126-9	2006	In vitro, BDNF induced HUVEC migration and tube formation on Matrigel, which could be significantly blocked by LY294002 and N(G)-nitro-L-arginine methyl ester (L-NAME) respectively; but BDNF induced HUVEC apoptosis could be blocked only by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	240-248	brain derived neurotrophic factor	Mus musculus	10-14
16687388-5	2006	The phosphatidylinositol 3-kinase (PI-3K) inhibitors wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one) inhibited early paraquat-induced increases in PKB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-127	protein tyrosine kinase 2 beta	Homo sapiens	175-178
16717100-8	2006	In contrast, phosphorylation of the p85 variant of S6K in response to T3 was not blocked by LY294002, wortmannin, or rapamycin, thus supporting a T3-activated pathway independent of PI3K and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	ribosomal protein S6 kinase B1	Homo sapiens	51-54
16767165-2	2006	Presence of serum or epidermal growth factor in the culture medium of LNCaP cells decreases apoptosis induced by the inhibition of phosphatidylinositol 3-kinase with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	epidermal growth factor	Homo sapiens	21-44
16767165-4	2006	Here, we investigated the mechanism(s) involved in serum or epidermal growth factor-mediated inhibition of LY294002-induced death in LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	epidermal growth factor	Homo sapiens	60-83
16767165-8	2006	Our results demonstrate that cell death induced by LY294002 is mediated by translocation of BAD and BAX proteins from the cytosol to the mitochondria.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	BCL2 associated X, apoptosis regulator	Homo sapiens	100-103
16872509-12	2006	A dominant-negative mutant of PI-3K, Deltap85, as well as PI-3K inhibitor LY294002, blocked HIMF-induced NF-kappaB activation and attenuated Flk-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	resistin like alpha	Mus musculus	92-96
16872509-12	2006	A dominant-negative mutant of PI-3K, Deltap85, as well as PI-3K inhibitor LY294002, blocked HIMF-induced NF-kappaB activation and attenuated Flk-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-114
16872509-12	2006	A dominant-negative mutant of PI-3K, Deltap85, as well as PI-3K inhibitor LY294002, blocked HIMF-induced NF-kappaB activation and attenuated Flk-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	kinase insert domain protein receptor	Mus musculus	141-146
16543472-7	2006	The phosphoinositol-3 kinase (PI3K) inhibitor LY294002 also decreased BCRP levels in K562/BCRP-MX10 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	70-74
16543472-7	2006	The phosphoinositol-3 kinase (PI3K) inhibitor LY294002 also decreased BCRP levels in K562/BCRP-MX10 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	90-94
16750184-7	2006	RESULTS: Inhibition of PI 3-kinase by Ly294002 or wortmannin, two inhibitors, decreased formation of ROS, phosphorylation of p38 MAPK, and TGFbeta expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	transforming growth factor beta 1	Homo sapiens	139-146
16764985-6	2006	LY294002, a PI3K-inhibitor, blocked SST-induced p-Akt-Ser473 and partially p-eNOS-Ser617, however, it did not reverse SST-induced NHE attenuation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	50-53
16818766-10	2006	H89, a protein kinase A inhibitor, and LY294002, a PI3K inhibitor, diminished PGE(2)-mediated augmentation of IL-10-induced STAT3 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	interleukin 10	Homo sapiens	110-115
16818766-10	2006	H89, a protein kinase A inhibitor, and LY294002, a PI3K inhibitor, diminished PGE(2)-mediated augmentation of IL-10-induced STAT3 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	signal transducer and activator of transcription 3	Homo sapiens	124-129
16764985-6	2006	LY294002, a PI3K-inhibitor, blocked SST-induced p-Akt-Ser473 and partially p-eNOS-Ser617, however, it did not reverse SST-induced NHE attenuation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 3	Homo sapiens	77-81
16818713-7	2006	Analysis of the radiation-induced H2AX phosphorylation revealed that BIBX, as well as the PI3K inhibitor LY294002, leads to a marked reduction of P-H2AX in K-RAS(mt)-A549 and MDA-MB-231 cells, but not in K-RAS(wt)-FaDu and HH4ded cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	H2A.X variant histone	Homo sapiens	148-152
16638750-7	2006	An increase in PI 3-kinase activity was found in 12-LOX-transfected PC-3 cells and inhibition of PI 3-kinase by LY294002 significantly reduced VEGF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	vascular endothelial growth factor A	Homo sapiens	143-147
16672722-10	2006	To determine signal transduction pathways involved in VEGFA"s regulation of testis morphogenesis, E13 testis were treated with LY 294002 (15 microM), a phosphoinositide 3-kinase (PI3K) pathway inhibitor, resulting in inhibition of both vascular density (46%) and cord formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-136	vascular endothelial growth factor A	Rattus norvegicus	54-59
16761312-7	2006	GIA activated the phosphatidylinositol 3-kinase (PI3 K)/Akt system and a specific inhibitor of PI3 K (LY294002) reduced sPLA(2)-induced release of TNF-alpha and CXCL8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	phospholipase A2 group X	Homo sapiens	120-127
16761312-7	2006	GIA activated the phosphatidylinositol 3-kinase (PI3 K)/Akt system and a specific inhibitor of PI3 K (LY294002) reduced sPLA(2)-induced release of TNF-alpha and CXCL8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	tumor necrosis factor	Homo sapiens	147-156
16761312-7	2006	GIA activated the phosphatidylinositol 3-kinase (PI3 K)/Akt system and a specific inhibitor of PI3 K (LY294002) reduced sPLA(2)-induced release of TNF-alpha and CXCL8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	C-X-C motif chemokine ligand 8	Homo sapiens	161-166
16439472-7	2006	Steatosis was associated with increased expression of microsomal triglyceride transfer protein (MTTP) mRNA and increased ALT release with over expression of ALT mRNA, all of which were completely prevented by inhibition of PI3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	235-243	microsomal triglyceride transfer protein	Mus musculus	54-94
16439472-7	2006	Steatosis was associated with increased expression of microsomal triglyceride transfer protein (MTTP) mRNA and increased ALT release with over expression of ALT mRNA, all of which were completely prevented by inhibition of PI3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	235-243	microsomal triglyceride transfer protein	Mus musculus	96-100
16439472-7	2006	Steatosis was associated with increased expression of microsomal triglyceride transfer protein (MTTP) mRNA and increased ALT release with over expression of ALT mRNA, all of which were completely prevented by inhibition of PI3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	235-243	glutamic pyruvic transaminase, soluble	Mus musculus	121-124
16439472-7	2006	Steatosis was associated with increased expression of microsomal triglyceride transfer protein (MTTP) mRNA and increased ALT release with over expression of ALT mRNA, all of which were completely prevented by inhibition of PI3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	235-243	glutamic pyruvic transaminase, soluble	Mus musculus	157-160
16819163-5	2006	LY294002, a phosphatidylinositol 3-kinase inhibitor that inhibits FBS-stimulated Akt phosphorylation, restored the sensitivity of HepG(2) cells to cAMP and API-2 (Akt/protein kinase B signaling inhibitor-2) also showed similar effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	81-84
16819163-5	2006	LY294002, a phosphatidylinositol 3-kinase inhibitor that inhibits FBS-stimulated Akt phosphorylation, restored the sensitivity of HepG(2) cells to cAMP and API-2 (Akt/protein kinase B signaling inhibitor-2) also showed similar effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cathelicidin antimicrobial peptide	Homo sapiens	147-151
16819163-5	2006	LY294002, a phosphatidylinositol 3-kinase inhibitor that inhibits FBS-stimulated Akt phosphorylation, restored the sensitivity of HepG(2) cells to cAMP and API-2 (Akt/protein kinase B signaling inhibitor-2) also showed similar effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	baculoviral IAP repeat containing 3	Homo sapiens	156-161
16819163-5	2006	LY294002, a phosphatidylinositol 3-kinase inhibitor that inhibits FBS-stimulated Akt phosphorylation, restored the sensitivity of HepG(2) cells to cAMP and API-2 (Akt/protein kinase B signaling inhibitor-2) also showed similar effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	163-166
16949833-5	2006	Furthermore, both the PI3K inhibitor LY294002 and the dominant negative AKT (DN-AKT) abolished the inhibitory effects of insulin, demonstrating that the inhibition of Smad2 activation by insulin was PI3K/AKT dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	insulin	Cricetulus griseus	121-128
16949833-5	2006	Furthermore, both the PI3K inhibitor LY294002 and the dominant negative AKT (DN-AKT) abolished the inhibitory effects of insulin, demonstrating that the inhibition of Smad2 activation by insulin was PI3K/AKT dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	mothers against decapentaplegic homolog 2	Cricetulus griseus	167-172
16949833-5	2006	Furthermore, both the PI3K inhibitor LY294002 and the dominant negative AKT (DN-AKT) abolished the inhibitory effects of insulin, demonstrating that the inhibition of Smad2 activation by insulin was PI3K/AKT dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	insulin	Cricetulus griseus	187-194
16818713-7	2006	Analysis of the radiation-induced H2AX phosphorylation revealed that BIBX, as well as the PI3K inhibitor LY294002, leads to a marked reduction of P-H2AX in K-RAS(mt)-A549 and MDA-MB-231 cells, but not in K-RAS(wt)-FaDu and HH4ded cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	KRAS proto-oncogene, GTPase	Homo sapiens	156-161
16787946-8	2006	Inhibition of PI 3-kinase by LY294002 produced strong and moderate reductions in IGF-I-stimulated P-Akt(Ser473) and P-Akt(Thr308), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	thymoma viral proto-oncogene 1	Mus musculus	118-121
16773206-2	2006	Colony formation assays showed that LY294002 enhanced heat sensitivity in two human lung cancer cell lines; H1299/wild-type p53 (wtp53) and H1299/mutated p53 (mp53) cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	tumor protein p53	Homo sapiens	124-127
16773206-2	2006	Colony formation assays showed that LY294002 enhanced heat sensitivity in two human lung cancer cell lines; H1299/wild-type p53 (wtp53) and H1299/mutated p53 (mp53) cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	tumor protein p53	Homo sapiens	131-134
16773206-4	2006	LY294002 suppressed the heat-induced accumulation of heat shock protein 27 (hsp27) and heat shock protein 72 (hsp72) in these cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heat shock protein family B (small) member 1	Homo sapiens	53-74
16773206-4	2006	LY294002 suppressed the heat-induced accumulation of heat shock protein 27 (hsp27) and heat shock protein 72 (hsp72) in these cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heat shock protein family B (small) member 1	Homo sapiens	76-81
16773206-4	2006	LY294002 suppressed the heat-induced accumulation of heat shock protein 27 (hsp27) and heat shock protein 72 (hsp72) in these cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heat shock protein family A (Hsp70) member 1A	Homo sapiens	87-108
16773206-4	2006	LY294002 suppressed the heat-induced accumulation of heat shock protein 27 (hsp27) and heat shock protein 72 (hsp72) in these cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heat shock protein family A (Hsp70) member 1A	Homo sapiens	110-115
16773206-6	2006	In addition, both the heat-induced phosphorylation of Akt and the accumulation of survivin were suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Homo sapiens	54-57
16773206-7	2006	These results suggest that LY294002 inhibits anti-apoptosis signaling through hsp27 and hsp72 as well as cell survival signaling through Akt and survivin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	heat shock protein family B (small) member 1	Homo sapiens	78-83
16773206-7	2006	These results suggest that LY294002 inhibits anti-apoptosis signaling through hsp27 and hsp72 as well as cell survival signaling through Akt and survivin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	heat shock protein family A (Hsp70) member 1A	Homo sapiens	88-93
16773206-7	2006	These results suggest that LY294002 inhibits anti-apoptosis signaling through hsp27 and hsp72 as well as cell survival signaling through Akt and survivin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	137-140
16773206-8	2006	LY294002 appears to be an attractive candidate for a p53-independent heat sensitizer in hyperthermic cancer therapy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor protein p53	Homo sapiens	53-56
16773209-6	2006	TSA transiently activated EGFR tyrosine phosphorylation and AKT activation in a time- and dose-dependent manner, which had been inhibited by EGFR inhibitor PD153035 and PI3 kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	epidermal growth factor receptor	Homo sapiens	26-30
16773209-7	2006	We also observed that TSA transiently induced survivin expression that had been inhibited by PD153035 and LY294002, suggesting that TSA-induced survivin expression is mediated by EGFR/PI3 kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	epidermal growth factor receptor	Homo sapiens	179-183
16989733-6	2006	AII-induced PLCgamma1 activation required both tyrosine kinase and PI3Kgamma since genistein and tyrphostin B48 (inhibitors of tyrosine kinase), LY294002 and wortmannin (inhibitors of PI3K) and anti-PI3Kgamma antibody abolished AII-induced stimulation of InsPs accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	angiotensinogen	Rattus norvegicus	0-3
16989733-6	2006	AII-induced PLCgamma1 activation required both tyrosine kinase and PI3Kgamma since genistein and tyrphostin B48 (inhibitors of tyrosine kinase), LY294002 and wortmannin (inhibitors of PI3K) and anti-PI3Kgamma antibody abolished AII-induced stimulation of InsPs accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	phospholipase C, gamma 1	Rattus norvegicus	12-21
16787946-8	2006	Inhibition of PI 3-kinase by LY294002 produced strong and moderate reductions in IGF-I-stimulated P-Akt(Ser473) and P-Akt(Thr308), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	insulin-like growth factor 1	Mus musculus	81-86
16787946-8	2006	Inhibition of PI 3-kinase by LY294002 produced strong and moderate reductions in IGF-I-stimulated P-Akt(Ser473) and P-Akt(Thr308), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	thymoma viral proto-oncogene 1	Mus musculus	100-103
16794735-6	2006	Leptin was not able to elicit electrical activity in PPKO POMC neurons, but application of the PI3K inhibitor LY294002 and the KATP blocker tolbutamide restored electrical activity and leptin-evoked firing of POMC neurons in these mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	pro-opiomelanocortin-alpha	Mus musculus	209-213
16624972-5	2006	2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002), a specific inhibitor of PI3-kinase, produced a further decrease of phosphorylated AKT in AA+Fe-treated E47 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	158-161
16510205-7	2006	Among the three putative STAT binding elements (SBE) in the HO-1 promoter, only the distal one was functional and when deleted, the remaining Luc induction was completely obliterated by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	237-245	heme oxygenase 1	Rattus norvegicus	60-64
16516256-3	2006	With specific inhibitors (wortmannin and LY294002), we found that PI3K/Akt signaling participated in the eNOS phosphorylation caused by TNT, whereas the ERK pathway did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Bos taurus	71-74
16849522-2	2006	Inhibition of PI3K in U87MG glioblastoma cells, which have activated PI3K/Akt activity secondary to phosphatase and tensin homologue deleted on chromosome 10 (PTEN) mutation, with LY294002 blunted the induction of HIF-1alpha protein and its targets vascular endothelial growth factor and glut1 mRNA in response to hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	hypoxia inducible factor 1 subunit alpha	Homo sapiens	214-224
16849522-2	2006	Inhibition of PI3K in U87MG glioblastoma cells, which have activated PI3K/Akt activity secondary to phosphatase and tensin homologue deleted on chromosome 10 (PTEN) mutation, with LY294002 blunted the induction of HIF-1alpha protein and its targets vascular endothelial growth factor and glut1 mRNA in response to hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	vascular endothelial growth factor A	Homo sapiens	249-283
16849522-2	2006	Inhibition of PI3K in U87MG glioblastoma cells, which have activated PI3K/Akt activity secondary to phosphatase and tensin homologue deleted on chromosome 10 (PTEN) mutation, with LY294002 blunted the induction of HIF-1alpha protein and its targets vascular endothelial growth factor and glut1 mRNA in response to hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	solute carrier family 2 member 1	Homo sapiens	288-293
16632475-8	2006	The protective ability of uPA is prevented by UO126, LY294002, by an MAPK targeting small interference RNA, and by a dominant negative Akt variant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	plasminogen activator, urokinase	Homo sapiens	26-29
16395716-3	2006	The hypoxia-stimulated activities of Rac1 and Cdc42 could be blocked by the phosphatidylinositol 3"-kinase (PI3K) inhibitor LY294002 and the protein tyrosine kinase (PTK) inhibitor genistein but were not affected by the p38MAPK inhibitor SB203580 or the MEK-1 inhibitor PD98059, suggesting that the hypoxia-mediated signals were through PI3K and PTK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	Rac family small GTPase 1	Homo sapiens	37-41
16395716-3	2006	The hypoxia-stimulated activities of Rac1 and Cdc42 could be blocked by the phosphatidylinositol 3"-kinase (PI3K) inhibitor LY294002 and the protein tyrosine kinase (PTK) inhibitor genistein but were not affected by the p38MAPK inhibitor SB203580 or the MEK-1 inhibitor PD98059, suggesting that the hypoxia-mediated signals were through PI3K and PTK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	cell division cycle 42	Homo sapiens	46-51
16395716-3	2006	The hypoxia-stimulated activities of Rac1 and Cdc42 could be blocked by the phosphatidylinositol 3"-kinase (PI3K) inhibitor LY294002 and the protein tyrosine kinase (PTK) inhibitor genistein but were not affected by the p38MAPK inhibitor SB203580 or the MEK-1 inhibitor PD98059, suggesting that the hypoxia-mediated signals were through PI3K and PTK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	76-106
16395716-3	2006	The hypoxia-stimulated activities of Rac1 and Cdc42 could be blocked by the phosphatidylinositol 3"-kinase (PI3K) inhibitor LY294002 and the protein tyrosine kinase (PTK) inhibitor genistein but were not affected by the p38MAPK inhibitor SB203580 or the MEK-1 inhibitor PD98059, suggesting that the hypoxia-mediated signals were through PI3K and PTK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	mitogen-activated protein kinase kinase 1	Homo sapiens	254-259
16571724-5	2006	Pretreatment of the endothelial cells with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked the shear stress-induced binding of nucleolin to the promoter, demonstrating its PI3K-dependent regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	nucleolin	Homo sapiens	159-168
16820027-7	2006	LY294002 blocked phosphorylation of Akt and the prolonged phosphorylation of FKHR and mTOR but did not impair long-term potentiation-induced phosphorylation of extracellular receptor kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	36-39
16449529-6	2006	BCR-induced glucose utilization is dependent upon phosphatidylinositol 3-kinase (PI-3K) activity as evidenced by inhibition of glucose uptake and glycolysis with LY294002 treatment of normal B cells and impaired glucose utilization in B cells deficient in the PI-3K regulatory subunit p85alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	BCR activator of RhoGEF and GTPase	Homo sapiens	0-3
16633357-13	2006	Combination of rPSGL-Ig with Reopro or with an inhibitor of Pi3K (LY294002), which reduces GPIIb-IIIa activation, showed to be more effective in inhibiting platelet aggregation, in comparison to the effects observed individually.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	integrin subunit alpha 2b	Homo sapiens	91-96
16633357-14	2006	5. rPSGL-Ig blocks P-selectin, whereas Reopro and LY294002 block GPIIb-IIIa and its activation, respectively, without a major effect on the percentage of platelets expressing P-selectin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	integrin subunit alpha 2b	Homo sapiens	65-70
16728588-12	2006	Leptin-stimulated invasion was effectively blocked by pharmacological inhibitors of JAK/STAT (AG490) and phosphatidylinositol 3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	leptin	Homo sapiens	0-6
16820027-7	2006	LY294002 blocked phosphorylation of Akt and the prolonged phosphorylation of FKHR and mTOR but did not impair long-term potentiation-induced phosphorylation of extracellular receptor kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	forkhead box O1	Rattus norvegicus	77-81
16820027-7	2006	LY294002 blocked phosphorylation of Akt and the prolonged phosphorylation of FKHR and mTOR but did not impair long-term potentiation-induced phosphorylation of extracellular receptor kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	86-90
16723489-11	2006	Selective inhibitors of MAPK (PD98059) and PI-3 kinase (LY294002) suppressed HGF-induced RVP by 86%+/-44% (P=0.015) and 97%+/-59% (P=0.021), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	hepatocyte growth factor	Homo sapiens	77-80
16704410-4	2006	The induction of heme oxygenase-1 in renal adenocarcinoma cells was blocked by actinomycin D and cycloheximide and was abolished by the phosphatidylinositol 3-kinase inhibitor, LY294002, but not by the inactive analog LY303511.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	heme oxygenase 1	Mus musculus	17-33
16644476-6	2006	Gel shift assays showed that LY294002 (LY29) potently increased interleukin (IL)-1-induced NF-kappaB DNA binding in human monocytic THP-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	nuclear factor kappa B subunit 1	Homo sapiens	91-100
16644476-6	2006	Gel shift assays showed that LY294002 (LY29) potently increased interleukin (IL)-1-induced NF-kappaB DNA binding in human monocytic THP-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-33	nuclear factor kappa B subunit 1	Homo sapiens	91-100
16644476-9	2006	LY29 treatment also augmented tumor necrosis factor (TNF)-mediated NF-kappaB DNA binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-4	tumor necrosis factor	Homo sapiens	30-51
16644476-9	2006	LY29 treatment also augmented tumor necrosis factor (TNF)-mediated NF-kappaB DNA binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-4	tumor necrosis factor	Homo sapiens	53-56
16644476-9	2006	LY29 treatment also augmented tumor necrosis factor (TNF)-mediated NF-kappaB DNA binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-4	nuclear factor kappa B subunit 1	Homo sapiens	67-76
16728278-10	2006	LY-294002 completely blocked these effects of IL-6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	interleukin 6	Homo sapiens	46-50
16728278-13	2006	IGF-I phosphorylated Akt and upregulated cyclin D1 in the CD56(+) KMS-21-BM cells, which was completely blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	insulin like growth factor 1	Homo sapiens	0-5
16728278-13	2006	IGF-I phosphorylated Akt and upregulated cyclin D1 in the CD56(+) KMS-21-BM cells, which was completely blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	AKT serine/threonine kinase 1	Homo sapiens	21-24
16728278-13	2006	IGF-I phosphorylated Akt and upregulated cyclin D1 in the CD56(+) KMS-21-BM cells, which was completely blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	cyclin D1	Homo sapiens	41-50
16728278-13	2006	IGF-I phosphorylated Akt and upregulated cyclin D1 in the CD56(+) KMS-21-BM cells, which was completely blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	neural cell adhesion molecule 1	Homo sapiens	58-62
16387404-5	2006	However, pretreatment of the cells with LY294002 and SB203580, inhibitors of PI3K and p38, respectively, BAPTA-AM, an intracellular Ca(2+) chelator, and antioxidants such as N-acetylcysteine (NAC) and Trolox had no effect on the alpha-chaconine-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	mitogen-activated protein kinase 1	Homo sapiens	86-89
16672314-6	2006	Consistent with this hypothesis, the selective phosphoinositol-3 kinase inhibitor LY294002 blocked the survival-promoting effects of GDNF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	glial cell derived neurotrophic factor	Rattus norvegicus	133-137
16508949-6	2006	In accordance with these findings, S1P stimulated phosphorylation of p42/p44 MAPK and Akt, which was attenuated by U0126, LY294002, or wortmannin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	mitogen activated protein kinase 3	Rattus norvegicus	73-76
16508949-6	2006	In accordance with these findings, S1P stimulated phosphorylation of p42/p44 MAPK and Akt, which was attenuated by U0126, LY294002, or wortmannin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	mitogen activated protein kinase 3	Rattus norvegicus	77-81
16508949-6	2006	In accordance with these findings, S1P stimulated phosphorylation of p42/p44 MAPK and Akt, which was attenuated by U0126, LY294002, or wortmannin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Rattus norvegicus	86-89
16526059-5	2006	Apoptotic cell death was induced by LY294002 (a pharmacological inhibitor of the phosphoinositide 3-kinase/Akt survival pathway), H2O2, and Z-LEHD-FMK (a caspase-9 inhibitor which has been recently reported to induce apoptosis in CEM cells).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	107-110
16709838-5	2006	Treatment of the cells with pharmacological inhibitors of PI3K, wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-1 (LY294002), similarly inhibits FasL-induced apoptosis and Akt/PKB phosphorylation, indicating that PI3K is an upstream mediator of Akt/PKB and is involved in Fas-mediated cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	Fas ligand	Homo sapiens	157-161
16734568-8	2006	The effect on M-CSF expression could be partially blocked by pyrrolidine-dithiocarbamate ammonium salt and LY294002 but not by NS398.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	colony stimulating factor 1	Homo sapiens	14-19
16540596-5	2006	Phosphatidylinositol 3-kinase (PI3K) inhibitors 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002) and wortmannin also inhibited the potentiating action of US.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	0-29
16571675-5	2006	Furthermore, LY294002 treatment down-regulated SREBP-2 or -1c gene targets and decreased cholesterol and fatty acid synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	sterol regulatory element binding transcription factor 2	Homo sapiens	47-61
16571675-6	2006	Fluorescence microscopy studies indicated that LY294002 disrupts transport of the SREBP escort protein, SCAP, from the endoplasmic reticulum to the Golgi.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	SREBF chaperone	Homo sapiens	104-108
16778084-6	2006	Furthermore, the PI3K-specific inhibitor LY294002 inhibited VEGF production by EMMPRIN-overexpressing cells in a dose- and time-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	vascular endothelial growth factor A	Homo sapiens	60-64
16778084-6	2006	Furthermore, the PI3K-specific inhibitor LY294002 inhibited VEGF production by EMMPRIN-overexpressing cells in a dose- and time-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	basigin (Ok blood group)	Homo sapiens	79-86
16732486-6	2006	Akt phosphorylation and cell growth were inhibited by PI3-K specific inhibitor LY294002 in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	0-3
16732486-7	2006	LY294002 markedly down regulated expression of EBV lytic gene BRLF1 protein Rta, BMRF1 protein EA-D, but not BZLF1 protein ZEBRA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BRLF1	Human gammaherpesvirus 4	62-67
16732486-7	2006	LY294002 markedly down regulated expression of EBV lytic gene BRLF1 protein Rta, BMRF1 protein EA-D, but not BZLF1 protein ZEBRA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	MAS related GPR family member F	Homo sapiens	76-79
16732486-7	2006	LY294002 markedly down regulated expression of EBV lytic gene BRLF1 protein Rta, BMRF1 protein EA-D, but not BZLF1 protein ZEBRA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BMRF1	Human gammaherpesvirus 4	81-86
16732486-9	2006	Down regulation of Rta by LY294002 occurred at the transcriptional level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	MAS related GPR family member F	Homo sapiens	19-22
16472257-5	2006	ILK activity, and CPI-17 and MLC20 phosphorylation were inhibited by LY294002 and in muscle cells expressing ILK(R211A) or treated with siRNA (small interfering RNA) for ILK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	myosin light chain 12B	Homo sapiens	29-34
16511866-6	2006	Coinjection of the phosphoinositide 3 kinase inhibitor LY294002 with EPO inhibited the protective effects of EPO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	erythropoietin	Rattus norvegicus	69-72
16511866-6	2006	Coinjection of the phosphoinositide 3 kinase inhibitor LY294002 with EPO inhibited the protective effects of EPO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	erythropoietin	Rattus norvegicus	109-112
16522636-5	2006	Leptin-mediated GSK3beta phosphorylation was prevented by the MEK/ERK inhibitor PD98059, the phosphatidylinositol 3-kinase inhibitor LY294002, or the protein kinase C inhibitor GF109203X.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	glycogen synthase kinase 3 beta	Mus musculus	16-24
16522636-6	2006	Exposure of cortical neurons to leptin also induced Ser-41 phosphorylation of the neuronal growth-associated protein GAP-43, an effect prevented by LY294002 and GF109203X but not by PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	leptin	Mus musculus	32-38
16522636-6	2006	Exposure of cortical neurons to leptin also induced Ser-41 phosphorylation of the neuronal growth-associated protein GAP-43, an effect prevented by LY294002 and GF109203X but not by PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	growth associated protein 43	Mus musculus	117-123
16522636-10	2006	At concentrations preventing GSK3beta phosphorylation, PD98059, LY294002, or GF109203X reversed the leptin-induced growth cone surface enlargement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	leptin	Mus musculus	100-106
16338971-8	2006	In contrast, the PI3-kinase inhibitors LY-294002 and wortmannin abolished the protective effects of both SOD/catalase and NGF on NE-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	catalase	Rattus norvegicus	109-117
16645453-12	2006	This protection was abolished by LY294002, which inhibited phosphorylation of protein kinase B/Akt and its downstream targets glycogen synthase kinase 3beta, endothelial nitric oxide synthase, and p70S6 kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Rattus norvegicus	95-98
16645453-12	2006	This protection was abolished by LY294002, which inhibited phosphorylation of protein kinase B/Akt and its downstream targets glycogen synthase kinase 3beta, endothelial nitric oxide synthase, and p70S6 kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	glycogen synthase kinase 3 beta	Rattus norvegicus	126-156
16531089-18	2006	Inhibitors of phosphatidylinositol-3 kinase (PI-3 kinase), wortmannin and LY294002 inhibited GVBD by IGF-I and b-insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	insulin like growth factor 1	Homo sapiens	101-106
16634987-5	2006	Furthermore, we show using the specific inhibitors LY294002 and PD98059 that insulin induced increased gelatinase activity via an intracellular signalling mechanism involving phosphatidylinositol-3 kinase (PI-3K) and the extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinases (MAPKs) respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	175-204
16634987-5	2006	Furthermore, we show using the specific inhibitors LY294002 and PD98059 that insulin induced increased gelatinase activity via an intracellular signalling mechanism involving phosphatidylinositol-3 kinase (PI-3K) and the extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinases (MAPKs) respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	mitogen activated protein kinase 3	Rattus norvegicus	221-262
16644687-9	2006	Wortmannin and LY294002 inhibited hyperthermia-induced HSP72 expression and phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	55-60
16644687-9	2006	Wortmannin and LY294002 inhibited hyperthermia-induced HSP72 expression and phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Rattus norvegicus	95-98
16455784-10	2006	We report that pregnancy adaptation of eNOS activation includes the reduced sensitivity to ERK-mediated attenuation of eNOS activity and enhanced stimulation of eNOS activity through a wortmannin-sensitive, LY294002-insensitive, Akt-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	nitric oxide synthase 3	Homo sapiens	39-43
16380156-12	2006	LY294002 treatment resulted in dose-dependent inhibition of Akt activation and cellular proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	60-63
16447257-7	2006	This effect of Ang1 could be prevented by wortmannin and LY-294002 pretreatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-66	angiopoietin 1	Homo sapiens	15-19
16466740-2	2006	As demonstrated here, Galphaq expression protects cardiomyocytes against apoptosis induced by treatment with 2-deoxyglucose (2DOG) and this protection is lost when Akt activation is prevented by treatment with LY294002 (an inhibitor of PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	G protein subunit alpha q	Canis lupus familiaris	22-29
16466740-2	2006	As demonstrated here, Galphaq expression protects cardiomyocytes against apoptosis induced by treatment with 2-deoxyglucose (2DOG) and this protection is lost when Akt activation is prevented by treatment with LY294002 (an inhibitor of PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	AKT serine/threonine kinase 1	Rattus norvegicus	164-167
16529824-6	2006	In addition, morphine-induced apoptosis seems to be dependent on the activation of phosphatidylinositol 3-kinase (PI3K), as PI3K inhibition by the PI3K inhibitor LY294002 significantly enhanced morphine-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	83-112
16731745-3	2006	Similarly, these same metastatic melanoma lines were also resistant to inhibitors of the phosphatidylinositol 3-kinase/Akt pathway (LY294002 and wortmannin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	AKT serine/threonine kinase 1	Homo sapiens	119-122
16474002-5	2006	We were surprised to find that another PI3K inhibitor, LY294002, strongly suppressed the production of iNOS and cytokines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	nitric oxide synthase 2, inducible	Mus musculus	103-107
16478297-6	2006	Specific inhibitors of PI3K, wortmannin and LY294002, completely blocked Akt activation and UV-induced TSP1 downregulation in keratinocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	73-76
16478297-6	2006	Specific inhibitors of PI3K, wortmannin and LY294002, completely blocked Akt activation and UV-induced TSP1 downregulation in keratinocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	thrombospondin 1	Homo sapiens	103-107
16418318-11	2006	Antisense ODN-mediated protection was abolished by LY-294002, confirming the involvement of the Akt/PKB survival pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-60	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
16418318-11	2006	Antisense ODN-mediated protection was abolished by LY-294002, confirming the involvement of the Akt/PKB survival pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-60	AKT serine/threonine kinase 1	Rattus norvegicus	100-103
16051251-9	2006	As observed with statins, inhibition of PI3-kinase activity by Ly294002 also blocked TNF-alpha-induced p65 translocation, but did not prevent IkappaBalpha phosphorylation nor IkappaBalpha degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	tumor necrosis factor	Homo sapiens	85-94
16051251-9	2006	As observed with statins, inhibition of PI3-kinase activity by Ly294002 also blocked TNF-alpha-induced p65 translocation, but did not prevent IkappaBalpha phosphorylation nor IkappaBalpha degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	RELA proto-oncogene, NF-kB subunit	Homo sapiens	103-106
16157472-5	2006	Blocking PI 3 kinase activity with Ly294002 attenuated IFN-gamma-induced MCP-1 protein and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	interferon gamma	Mus musculus	55-64
16157472-5	2006	Blocking PI 3 kinase activity with Ly294002 attenuated IFN-gamma-induced MCP-1 protein and mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	chemokine (C-C motif) ligand 2	Mus musculus	73-78
16565371-7	2006	The synergistic effects of FGF-2 and Y27632 were completely blocked by LY294002 (PI 3-kinase inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	fibroblast growth factor 2	Homo sapiens	27-32
16547273-9	2006	Induction of VCAM-1 by OSM was diminished by pharmacological inhibitors of PI3K (LY294002) but not inhibitors of ERK1/2 (PD98059) or p38 MAPK (SB203580).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	vascular cell adhesion molecule 1	Mus musculus	13-19
16377761-7	2006	This EPO-induced protection was sensitive to a phosphatidylinositol 3-kinase (PI3K) inhibitor, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), in sham.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-143	erythropoietin	Rattus norvegicus	5-8
16377761-7	2006	This EPO-induced protection was sensitive to a phosphatidylinositol 3-kinase (PI3K) inhibitor, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), in sham.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-143	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	47-76
16377761-7	2006	This EPO-induced protection was sensitive to a phosphatidylinositol 3-kinase (PI3K) inhibitor, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), in sham.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	erythropoietin	Rattus norvegicus	5-8
16377761-7	2006	This EPO-induced protection was sensitive to a phosphatidylinositol 3-kinase (PI3K) inhibitor, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), in sham.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	47-76
16722795-7	2006	EGF-induced MMP-2 activity was significantly inhibited by treatment of PD153035, U0126, and LY294002, but not SB203580 and JNK inhibitor, suggesting that ERK and the phosphatidylinositol-3-kinase (PI3K)/AKT pathways selectively mediate EGF-stimulated MMP-2 activity and cell migration in cultured HLECs in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	epidermal growth factor	Homo sapiens	0-3
16722795-7	2006	EGF-induced MMP-2 activity was significantly inhibited by treatment of PD153035, U0126, and LY294002, but not SB203580 and JNK inhibitor, suggesting that ERK and the phosphatidylinositol-3-kinase (PI3K)/AKT pathways selectively mediate EGF-stimulated MMP-2 activity and cell migration in cultured HLECs in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	matrix metallopeptidase 2	Homo sapiens	12-17
16722795-7	2006	EGF-induced MMP-2 activity was significantly inhibited by treatment of PD153035, U0126, and LY294002, but not SB203580 and JNK inhibitor, suggesting that ERK and the phosphatidylinositol-3-kinase (PI3K)/AKT pathways selectively mediate EGF-stimulated MMP-2 activity and cell migration in cultured HLECs in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	mitogen-activated protein kinase 1	Homo sapiens	154-157
16722795-7	2006	EGF-induced MMP-2 activity was significantly inhibited by treatment of PD153035, U0126, and LY294002, but not SB203580 and JNK inhibitor, suggesting that ERK and the phosphatidylinositol-3-kinase (PI3K)/AKT pathways selectively mediate EGF-stimulated MMP-2 activity and cell migration in cultured HLECs in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	166-195
16722795-7	2006	EGF-induced MMP-2 activity was significantly inhibited by treatment of PD153035, U0126, and LY294002, but not SB203580 and JNK inhibitor, suggesting that ERK and the phosphatidylinositol-3-kinase (PI3K)/AKT pathways selectively mediate EGF-stimulated MMP-2 activity and cell migration in cultured HLECs in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	203-206
16722795-7	2006	EGF-induced MMP-2 activity was significantly inhibited by treatment of PD153035, U0126, and LY294002, but not SB203580 and JNK inhibitor, suggesting that ERK and the phosphatidylinositol-3-kinase (PI3K)/AKT pathways selectively mediate EGF-stimulated MMP-2 activity and cell migration in cultured HLECs in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	epidermal growth factor	Homo sapiens	236-239
16722795-7	2006	EGF-induced MMP-2 activity was significantly inhibited by treatment of PD153035, U0126, and LY294002, but not SB203580 and JNK inhibitor, suggesting that ERK and the phosphatidylinositol-3-kinase (PI3K)/AKT pathways selectively mediate EGF-stimulated MMP-2 activity and cell migration in cultured HLECs in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	matrix metallopeptidase 2	Homo sapiens	251-256
16439036-4	2006	Activation of Akt by carbachol was antagonized by atropine and inhibited by LY294002 and PP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	14-17
16288223-0	2006	The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	mutS homolog 3	Homo sapiens	99-103
16288223-4	2006	We found that cotreatment of drug-resistant HT29RDB colon cancer cells with the topoisomerase inhibitor doxorubicin and the PI3K-inhibitor LY294002 resulted in massive apoptosis, while cotreatment with the Mek inhibitors PD98059 or U0126 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	mitogen-activated protein kinase kinase 7	Homo sapiens	206-209
16288223-9	2006	We conclude that the PI3K inhibitor LY294002 may have therapeutic potential when combined with doxorubicin in the treatment of MRP1-mediated drug resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	mutS homolog 3	Homo sapiens	127-131
16507596-6	2006	The proxidant- and CoCl2-mediated upregulation of CT-1 was significantly inhibited in the presence of the ERK1,2 antagonist UO126, the JNK antagonist SP600125, the p38 antagonist SKF86002, the PI3-kinase antagonist LY294002, the Jak-2 antagonist AG490 as well as in the presence of free radical scavengers.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	cardiotrophin 1	Mus musculus	50-54
16442704-4	2006	Inhibition of signalling via c-Jun NH2-terminal kinase (JNK) with SP600125 or PI3-kinase/Akt with LY294002 abolished the effects of G-Gly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	AKT serine/threonine kinase 1	Homo sapiens	89-92
16245312-6	2006	The PDGF-mediated induction of TN-C expression was inhibited by the treatment of fibroblasts with a selective phosphoinositide 3-kinase (PI3K) inhibitor, wortmannin, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	tenascin C	Homo sapiens	31-35
16374482-4	2006	IL-13-mediated TN-C expression was inhibited by treatment with wortmannin or LY294002, or Calphostin C. IL-13 induced the phosphorylation of the phosphoinositide 3-kinase (PI3K) regulatory subunit p85, induced tyrosine phosphorylation of Akt, upregulated Akt kinase activity, and activated protein kinase C (PKC)-delta and -epsilon.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	interleukin 13	Homo sapiens	0-5
16374482-4	2006	IL-13-mediated TN-C expression was inhibited by treatment with wortmannin or LY294002, or Calphostin C. IL-13 induced the phosphorylation of the phosphoinositide 3-kinase (PI3K) regulatory subunit p85, induced tyrosine phosphorylation of Akt, upregulated Akt kinase activity, and activated protein kinase C (PKC)-delta and -epsilon.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	tenascin C	Homo sapiens	15-19
16374482-4	2006	IL-13-mediated TN-C expression was inhibited by treatment with wortmannin or LY294002, or Calphostin C. IL-13 induced the phosphorylation of the phosphoinositide 3-kinase (PI3K) regulatory subunit p85, induced tyrosine phosphorylation of Akt, upregulated Akt kinase activity, and activated protein kinase C (PKC)-delta and -epsilon.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	interleukin 13	Homo sapiens	104-109
16374482-4	2006	IL-13-mediated TN-C expression was inhibited by treatment with wortmannin or LY294002, or Calphostin C. IL-13 induced the phosphorylation of the phosphoinositide 3-kinase (PI3K) regulatory subunit p85, induced tyrosine phosphorylation of Akt, upregulated Akt kinase activity, and activated protein kinase C (PKC)-delta and -epsilon.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	145-170
16722146-8	2006	Further, in Ca922 and HSC6 but not in HOC313, caspase 8 inhibitor restored loss of viability induced either with LY294002 and TRAIL or even with etoposide alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	caspase 8	Homo sapiens	46-55
16723445-8	2006	All FGF-2 actions were blocked by the phosphatidylinositol (PI) 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	fibroblast growth factor 2	Homo sapiens	4-9
16571675-3	2006	SREBP-2 processing increased in response to various cholesterol depletion approaches (including statin treatment) and this increase was blunted by treatment with a potent and specific inhibitor of PI3K, LY294002, or when a plasmid encoding a dominant-negative form of Akt (DN-Akt) was expressed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	sterol regulatory element binding transcription factor 2	Homo sapiens	0-7
16571675-4	2006	LY294002 also suppressed SREBP-2 processing induced by insulin-like growth factor-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	sterol regulatory element binding transcription factor 2	Homo sapiens	25-32
16571675-4	2006	LY294002 also suppressed SREBP-2 processing induced by insulin-like growth factor-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 1	Homo sapiens	55-83
16818499-6	2006	The phosphatidylinositol 3-kinase inhibitor LY294002 blocked the increase in VEGF mRNA, implicating c-Kit-mediated activation of phosphatidylinositol 3-kinase in the phenomenon.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	vascular endothelial growth factor A	Homo sapiens	77-81
16818499-6	2006	The phosphatidylinositol 3-kinase inhibitor LY294002 blocked the increase in VEGF mRNA, implicating c-Kit-mediated activation of phosphatidylinositol 3-kinase in the phenomenon.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	100-105
16836907-0	2006	[Influence of LY294002 on protein kinase B expression in salivary adenoid cystic carcinoma (SACC)-83 and SACC-LM cells].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	protein tyrosine kinase 2 beta	Homo sapiens	26-42
16836907-1	2006	OBJECTIVE: To investigate the influence of LY294002 on protein kinase B expression in salivary adenoid cystic carcinoma cells (SACC).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	protein tyrosine kinase 2 beta	Homo sapiens	55-71
16836907-2	2006	METHODS: Using Western-blot and RT-PCR detected the protein and mRNA level of protein kinase B (PKB) both in cell line, absent and present LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	protein tyrosine kinase 2 beta	Homo sapiens	78-94
16836907-2	2006	METHODS: Using Western-blot and RT-PCR detected the protein and mRNA level of protein kinase B (PKB) both in cell line, absent and present LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	protein tyrosine kinase 2 beta	Homo sapiens	96-99
16836907-5	2006	The expression of PKB (Ser(473)) in SACC cell lines with LY294002 was lower than in SACC cell lines without LY294002 (P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	protein tyrosine kinase 2 beta	Homo sapiens	18-21
16836907-5	2006	The expression of PKB (Ser(473)) in SACC cell lines with LY294002 was lower than in SACC cell lines without LY294002 (P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	protein tyrosine kinase 2 beta	Homo sapiens	18-21
16836907-8	2006	In vitro, LY294002 can inhibit protein expression of PKB (Ser(473)) in SACC-83 cells and SACC-LM cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	protein tyrosine kinase 2 beta	Homo sapiens	53-56
16723520-9	2006	The gas6 protective effect was abrogated by the Axl decoy receptor Axl-Fc, by the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one], and in Akt1(-/-) oligodendrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	growth arrest specific 6	Homo sapiens	4-8
16723520-9	2006	The gas6 protective effect was abrogated by the Axl decoy receptor Axl-Fc, by the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one], and in Akt1(-/-) oligodendrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	AKT serine/threonine kinase 1	Homo sapiens	197-201
16472257-5	2006	ILK activity, and CPI-17 and MLC20 phosphorylation were inhibited by LY294002 and in muscle cells expressing ILK(R211A) or treated with siRNA (small interfering RNA) for ILK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	integrin linked kinase	Homo sapiens	0-3
16472257-5	2006	ILK activity, and CPI-17 and MLC20 phosphorylation were inhibited by LY294002 and in muscle cells expressing ILK(R211A) or treated with siRNA (small interfering RNA) for ILK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	protein phosphatase 1 regulatory inhibitor subunit 14A	Homo sapiens	18-24
16707436-9	2006	Exposure to LY294002 or wortmannin decreased Akt activation and GSK-3 phosphorylation and reduced cell growth by up to 70% through induction of cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Homo sapiens	45-48
16670329-8	2006	Such effect of inhibiting PI3K with wortmannin was mimicked by the PI3K inhibitor LY294002, and, conversely, a constitutively active PI3K prevented p38 activation in response to flagellin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	mitogen-activated protein kinase 14	Mus musculus	148-151
16563531-9	2006	Furthermore, LY294002 (PI3 kinase inhibitor) blocked the activation of Akt by apelin and abolished the apelin-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	peptidase inhibitor 3	Homo sapiens	23-26
16563531-9	2006	Furthermore, LY294002 (PI3 kinase inhibitor) blocked the activation of Akt by apelin and abolished the apelin-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	71-74
16563531-9	2006	Furthermore, LY294002 (PI3 kinase inhibitor) blocked the activation of Akt by apelin and abolished the apelin-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	apelin	Homo sapiens	78-84
16563531-9	2006	Furthermore, LY294002 (PI3 kinase inhibitor) blocked the activation of Akt by apelin and abolished the apelin-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	apelin	Homo sapiens	103-109
16522636-5	2006	Leptin-mediated GSK3beta phosphorylation was prevented by the MEK/ERK inhibitor PD98059, the phosphatidylinositol 3-kinase inhibitor LY294002, or the protein kinase C inhibitor GF109203X.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	leptin	Mus musculus	0-6
16651432-6	2006	Here we report that apoptotic cell death of PTEN-deficient LNCaP and PC3 prostate cancer cells induced by the PI3K inhibitor LY294002 can be abrogated by disrupting Fas/Fas ligand (FasL) interactions with recombinant Fas:Fc fusion protein or FasL neutralizing antibody (Nok-1), or by expressing dominant-negative Fas-associated death domain.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	proprotein convertase subtilisin/kexin type 1	Homo sapiens	69-72
16651432-6	2006	Here we report that apoptotic cell death of PTEN-deficient LNCaP and PC3 prostate cancer cells induced by the PI3K inhibitor LY294002 can be abrogated by disrupting Fas/Fas ligand (FasL) interactions with recombinant Fas:Fc fusion protein or FasL neutralizing antibody (Nok-1), or by expressing dominant-negative Fas-associated death domain.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	Fas ligand	Homo sapiens	169-179
16651432-6	2006	Here we report that apoptotic cell death of PTEN-deficient LNCaP and PC3 prostate cancer cells induced by the PI3K inhibitor LY294002 can be abrogated by disrupting Fas/Fas ligand (FasL) interactions with recombinant Fas:Fc fusion protein or FasL neutralizing antibody (Nok-1), or by expressing dominant-negative Fas-associated death domain.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	Fas ligand	Homo sapiens	181-185
16651432-6	2006	Here we report that apoptotic cell death of PTEN-deficient LNCaP and PC3 prostate cancer cells induced by the PI3K inhibitor LY294002 can be abrogated by disrupting Fas/Fas ligand (FasL) interactions with recombinant Fas:Fc fusion protein or FasL neutralizing antibody (Nok-1), or by expressing dominant-negative Fas-associated death domain.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	Fas ligand	Homo sapiens	242-246
16455066-7	2006	Glc-HSA-induced E-selectin expression was suppressed by the phosphatidylinositol 3 kinase (PI3K) inhibitors wortmannin and LY294002, the protein kinase B (PKB) inhibitor ML-9, the IkappaB kinase (IKK) inhibitor BAY117082, and the Jun N-terminal kinase (JNK) inhibitor SP600125, On the other hand, the protein kinase C inhibitors calphostin C and H-7 did not suppress Glc-HSA-induced E-selectin expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	selectin E	Homo sapiens	16-26
16634807-8	2006	The addition of sublytic C5b-9 apparently increased the protein of Akt phosphorylation, whereas PI3-k inhibitor LY294002 could clearly reduce the increase of TSP-1 induced by sublytic C5b-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	WAP four-disulfide core domain 15B	Rattus norvegicus	96-99
16634807-8	2006	The addition of sublytic C5b-9 apparently increased the protein of Akt phosphorylation, whereas PI3-k inhibitor LY294002 could clearly reduce the increase of TSP-1 induced by sublytic C5b-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	thrombospondin 1	Rattus norvegicus	158-163
16506055-6	2006	The insulin-induced increase of HIF-1alpha is blunted by the translation inhibitor cycloheximide, LY294002, PD98059, SP600125 and rapamycin, but not by SB203580.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	insulin	Homo sapiens	4-11
16506055-6	2006	The insulin-induced increase of HIF-1alpha is blunted by the translation inhibitor cycloheximide, LY294002, PD98059, SP600125 and rapamycin, but not by SB203580.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	32-42
16644672-4	2006	The effect of GLP-1 was suppressed by inhibitors of EGFR (AG1478) and PI 3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	glucagon	Rattus norvegicus	14-19
16644672-5	2006	In contrast, LY294002 but not AG1478 suppressed insulin-induced FoxO1 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	forkhead box O1	Rattus norvegicus	64-69
16406609-3	2006	Here, we report that two structurally distinct PI3K inhibitors, wortmannin and LY294002, inhibited insulin-induced activation of ERK1/2 but had no effect on EGF-induced activation of ERK1/2 in hepatocellular carcinoma BEL-7402 and SMMC-7721 cells, breast cancer MCF-7 cells, and prostate cancer LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	insulin	Homo sapiens	99-106
16406609-3	2006	Here, we report that two structurally distinct PI3K inhibitors, wortmannin and LY294002, inhibited insulin-induced activation of ERK1/2 but had no effect on EGF-induced activation of ERK1/2 in hepatocellular carcinoma BEL-7402 and SMMC-7721 cells, breast cancer MCF-7 cells, and prostate cancer LNCaP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	mitogen-activated protein kinase 3	Homo sapiens	129-135
16427044-8	2006	Inhibition of PI-3K with low-dose LY294002, or MAPK with PD98059 also suppressed the mTOR/p70 S6k pathway, and correlated with the blockage of IFN-gamma-induced dephosphorylation of pY-STAT3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	interferon gamma	Homo sapiens	143-152
16427044-9	2006	Simultaneously, treatment with LY294002, PD98059, or rapamycin abolished IFN-gamma-induced apoptosis in M12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	interferon gamma	Homo sapiens	73-82
16650001-9	2006	The PI3K inhibitor, LY294002, blocked cartducin-stimulated Akt phosphorylation and a decrease in cartducin-induced DNA synthesis in N1511 cells was also observed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	59-62
16622226-8	2006	K252a, an inhibitor of TrkA receptor, and LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), reduced the toxin-induced production of O2(-) and phosphorylation of PDK1, but not the formation of DG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	3-phosphoinositide-dependent protein kinase 1	Oryctolagus cuniculus	175-179
16516918-7	2006	The effect of bradykinin on GSK-3beta phosphorylation was blocked by wortmannin and LY294002, and bradykinin increased Akt phosphorylation at reperfusion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	glycogen synthase kinase 3 beta	Rattus norvegicus	28-37
16731750-6	2006	The radiation-induced signaling activation is mediated by PI3K because inhibition of PI3K with LY294002 inhibited the increase in downstream mTOR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	mechanistic target of rapamycin kinase	Homo sapiens	141-145
16417967-6	2006	Both protein and mRNA levels of iNOS expression were abrogated by specific inhibitors, SP600125 (JNK inhibitor, 20 microM), PD98059 (ERKs inhibitor, 50 microM), or LY294002 (PI 3-kinase inhibitor, 20 microM), but not by SB203580 (20 microM), a p38 specific inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	nitric oxide synthase 2, inducible	Mus musculus	32-36
16490785-5	2006	Treatment of cells with LY294002, an inhibitor of the PI3K-Akt pathway, completely blocked CS-induced FRA-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	59-62
16490785-5	2006	Treatment of cells with LY294002, an inhibitor of the PI3K-Akt pathway, completely blocked CS-induced FRA-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	102-107
19771269-7	2006	Either wortmannin or LY294002, combined with NaBT, enhanced the activation of caspase 3 and caspase 9, and this enhanced the subsequent cleavage of poly (ADP-ribose) polymerase (PARP).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	caspase 3	Homo sapiens	78-87
19771269-7	2006	Either wortmannin or LY294002, combined with NaBT, enhanced the activation of caspase 3 and caspase 9, and this enhanced the subsequent cleavage of poly (ADP-ribose) polymerase (PARP).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	caspase 9	Homo sapiens	92-101
19771269-7	2006	Either wortmannin or LY294002, combined with NaBT, enhanced the activation of caspase 3 and caspase 9, and this enhanced the subsequent cleavage of poly (ADP-ribose) polymerase (PARP).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	poly(ADP-ribose) polymerase 1	Homo sapiens	148-176
19771269-7	2006	Either wortmannin or LY294002, combined with NaBT, enhanced the activation of caspase 3 and caspase 9, and this enhanced the subsequent cleavage of poly (ADP-ribose) polymerase (PARP).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	poly(ADP-ribose) polymerase 1	Homo sapiens	178-182
16542348-2	2006	The metabolic inhibitors of phosphatidyl-inositol-3-kinase (PI-3K, LY294002) and of MAPKK/ERK kinase (MEK, PD98059) differently affected insulin-stimulated myogenesis of the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	28-58
16542348-7	2006	Accordingly, inhibition of insulin action by LY294002, but not PD98059, was accompanied with a reduced level of Ser473-phosphorylated Akt with additional loss of myogenin protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Rattus norvegicus	134-137
16542348-7	2006	Accordingly, inhibition of insulin action by LY294002, but not PD98059, was accompanied with a reduced level of Ser473-phosphorylated Akt with additional loss of myogenin protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	myogenin	Rattus norvegicus	162-170
16374778-9	2006	Phagocytosis by CR3/MAC-1 and SRAI/II was further inhibited by PI3K inhibitors wortmannin and LY-294002 and PLCgamma inhibitor U-73122.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-103	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	16-19
16374778-9	2006	Phagocytosis by CR3/MAC-1 and SRAI/II was further inhibited by PI3K inhibitors wortmannin and LY-294002 and PLCgamma inhibitor U-73122.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-103	integrin subunit alpha M	Homo sapiens	20-25
16525641-7	2006	Treatment with either ZD1839 or LY294002 (the latter, a PI3K inhibitor) suppressed phosphorylation of AKT by Western blot.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	102-105
16525641-8	2006	Both ZD1839 and LY294002 significantly suppressed colony formation by clonogenic assay; however, U0126 (a MEK1/2 inhibitor), SB203580 (a p38 inhibitor), and SP600125 (a JNK inhibitor) had no effect on colony formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	mitogen-activated protein kinase kinase 1	Homo sapiens	106-112
16525641-8	2006	Both ZD1839 and LY294002 significantly suppressed colony formation by clonogenic assay; however, U0126 (a MEK1/2 inhibitor), SB203580 (a p38 inhibitor), and SP600125 (a JNK inhibitor) had no effect on colony formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	mitogen-activated protein kinase 14	Homo sapiens	137-140
16525641-8	2006	Both ZD1839 and LY294002 significantly suppressed colony formation by clonogenic assay; however, U0126 (a MEK1/2 inhibitor), SB203580 (a p38 inhibitor), and SP600125 (a JNK inhibitor) had no effect on colony formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	mitogen-activated protein kinase 8	Homo sapiens	169-172
16136056-4	2006	Inhibition of Akt activity by the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) inhibitor, LY294002, abolished rhEPO-increased Ngn1 mRNA levels and the effects of rhEPO on neural progenitor cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
16136056-4	2006	Inhibition of Akt activity by the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) inhibitor, LY294002, abolished rhEPO-increased Ngn1 mRNA levels and the effects of rhEPO on neural progenitor cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 1	Rattus norvegicus	64-67
16136056-4	2006	Inhibition of Akt activity by the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) inhibitor, LY294002, abolished rhEPO-increased Ngn1 mRNA levels and the effects of rhEPO on neural progenitor cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	69-77
16136056-4	2006	Inhibition of Akt activity by the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) inhibitor, LY294002, abolished rhEPO-increased Ngn1 mRNA levels and the effects of rhEPO on neural progenitor cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	neurogenin 1	Rattus norvegicus	126-130
16567092-4	2006	Inhibitory role of LY294002 on activation of Akt induced by E2 and its estrogen antagonist, ICI182780 were also tested.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	45-48
16567092-8	2006	PI3K inhibitor, LY294002, stopped the activating Akt in a dose-dependent manner and 50 microM LY294002 completely blocked the activation of Akt induced by E2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	49-52
16567092-8	2006	PI3K inhibitor, LY294002, stopped the activating Akt in a dose-dependent manner and 50 microM LY294002 completely blocked the activation of Akt induced by E2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	140-143
16567092-8	2006	PI3K inhibitor, LY294002, stopped the activating Akt in a dose-dependent manner and 50 microM LY294002 completely blocked the activation of Akt induced by E2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	AKT serine/threonine kinase 1	Homo sapiens	49-52
16567092-8	2006	PI3K inhibitor, LY294002, stopped the activating Akt in a dose-dependent manner and 50 microM LY294002 completely blocked the activation of Akt induced by E2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	AKT serine/threonine kinase 1	Homo sapiens	140-143
16472761-6	2006	Moreover, LY294002, but not PD98059, inhibited the PSA and AR suppression effect by EGF in concurrence with the suppression of phosphorylation levels of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	153-156
16428383-6	2006	Consistent with these data, NEU3 markedly inhibited staurosporine-induced caspase-3 activity and enhanced IL-6-dependent inhibition, which was abolished by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	neuraminidase 3	Homo sapiens	28-32
16428383-6	2006	Consistent with these data, NEU3 markedly inhibited staurosporine-induced caspase-3 activity and enhanced IL-6-dependent inhibition, which was abolished by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	caspase 3	Homo sapiens	74-83
16428383-6	2006	Consistent with these data, NEU3 markedly inhibited staurosporine-induced caspase-3 activity and enhanced IL-6-dependent inhibition, which was abolished by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	interleukin 6	Homo sapiens	106-110
16428383-7	2006	Furthermore, IL-6 promoted Rho activation, and the effect was potentiated by NEU3, leading to increased cell motility that was again affected by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	interleukin 6	Homo sapiens	13-17
16428383-7	2006	Furthermore, IL-6 promoted Rho activation, and the effect was potentiated by NEU3, leading to increased cell motility that was again affected by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	neuraminidase 3	Homo sapiens	77-81
16336212-2	2006	In the present study, we show in de-endothelialized VSM strips that the PI3K (phosphoinositide 3-kinase) inhibitors LY294002 and wortmannin inhibited KCl membrane depolarization- and noradrenaline-induced Rho activation and MYPT1 phosphorylation, with concomitant inhibition of MLC (20-kDa myosin light chain) phosphorylation and contraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	224-229
16507596-6	2006	The proxidant- and CoCl2-mediated upregulation of CT-1 was significantly inhibited in the presence of the ERK1,2 antagonist UO126, the JNK antagonist SP600125, the p38 antagonist SKF86002, the PI3-kinase antagonist LY294002, the Jak-2 antagonist AG490 as well as in the presence of free radical scavengers.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	mitogen-activated protein kinase 3	Mus musculus	106-112
16619474-1	2006	BACKGROUND: This study aimed to evaluate the impact of selective abrogation of either the MEK/ERK1/2 (UO126 or PD98059) or the PI3K/AKT (LY294002) signaling cascade on cell proliferation, motility and invasion and production of VEGF (collectively termed pro-metastasis phenotypes) in cultured malignant pleural mesothelioma (MPM) cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	AKT serine/threonine kinase 1	Homo sapiens	132-135
16564100-6	2006	The up-regulation and phosphorylation of PKB by tryptase could be abolished by either phosphoinositol-3-kinase (PI3K) inhibitor (LY294002) at 10 microM or antisense PKB cDNA transfection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	protein tyrosine kinase 2 beta	Homo sapiens	41-44
16505019-8	2006	IGF-1 enhanced the production of Ln-5 in both a dose- and time-dependent manner, and this upregulation was blocked by pretreatment with alphaIR3 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	insulin like growth factor 1	Homo sapiens	0-5
16478789-6	2006	The level of lipocalin 2, renin 1 and receptor-activity-modifying protein 3 genes expressed by adipose cells was also decreased in PKBalpha-deficient MEFs, and are inhibited by LY294002 treatment during early adipocyte differentiation of 3T3-L1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	lipocalin 2	Mus musculus	13-24
16478789-6	2006	The level of lipocalin 2, renin 1 and receptor-activity-modifying protein 3 genes expressed by adipose cells was also decreased in PKBalpha-deficient MEFs, and are inhibited by LY294002 treatment during early adipocyte differentiation of 3T3-L1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	renin 1 structural	Mus musculus	26-33
16478789-6	2006	The level of lipocalin 2, renin 1 and receptor-activity-modifying protein 3 genes expressed by adipose cells was also decreased in PKBalpha-deficient MEFs, and are inhibited by LY294002 treatment during early adipocyte differentiation of 3T3-L1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	receptor (calcitonin) activity modifying protein 3	Mus musculus	38-75
16722146-4	2006	A similar tendency was shown by further analyses with cisplatin, 5-fluorouracil, LY294002, and combined treatment with LY294002 and TNF-related apoptosis-inducing ligand (TRAIL).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	TNF superfamily member 10	Homo sapiens	171-176
16709838-5	2006	Treatment of the cells with pharmacological inhibitors of PI3K, wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-1 (LY294002), similarly inhibits FasL-induced apoptosis and Akt/PKB phosphorylation, indicating that PI3K is an upstream mediator of Akt/PKB and is involved in Fas-mediated cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	184-191
16709838-5	2006	Treatment of the cells with pharmacological inhibitors of PI3K, wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-1 (LY294002), similarly inhibits FasL-induced apoptosis and Akt/PKB phosphorylation, indicating that PI3K is an upstream mediator of Akt/PKB and is involved in Fas-mediated cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	257-264
16546963-6	2006	In MDA-MB468 cells, cerulenin- and LY294002-mediated apoptosis was associated with caspase-3 activation and the release of cytochrome c from mitochondria to cytosol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	caspase 3	Homo sapiens	83-92
16546963-6	2006	In MDA-MB468 cells, cerulenin- and LY294002-mediated apoptosis was associated with caspase-3 activation and the release of cytochrome c from mitochondria to cytosol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	cytochrome c, somatic	Homo sapiens	123-135
16546963-8	2006	Treatment of cells with cerulenin and LY294002 down-regulated the protein levels of X chromosome-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis 1 (cIAP-1), and Akt, whereas the levels of mitogen-activated protein/extracellular signal-regulated kinase kinase and other antiapoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xl) did not change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	X-linked inhibitor of apoptosis	Homo sapiens	84-126
16546963-8	2006	Treatment of cells with cerulenin and LY294002 down-regulated the protein levels of X chromosome-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis 1 (cIAP-1), and Akt, whereas the levels of mitogen-activated protein/extracellular signal-regulated kinase kinase and other antiapoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xl) did not change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	X-linked inhibitor of apoptosis	Homo sapiens	128-132
16546963-8	2006	Treatment of cells with cerulenin and LY294002 down-regulated the protein levels of X chromosome-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis 1 (cIAP-1), and Akt, whereas the levels of mitogen-activated protein/extracellular signal-regulated kinase kinase and other antiapoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xl) did not change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	baculoviral IAP repeat containing 2	Homo sapiens	135-168
16546963-8	2006	Treatment of cells with cerulenin and LY294002 down-regulated the protein levels of X chromosome-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis 1 (cIAP-1), and Akt, whereas the levels of mitogen-activated protein/extracellular signal-regulated kinase kinase and other antiapoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xl) did not change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	baculoviral IAP repeat containing 2	Homo sapiens	170-176
16546963-8	2006	Treatment of cells with cerulenin and LY294002 down-regulated the protein levels of X chromosome-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis 1 (cIAP-1), and Akt, whereas the levels of mitogen-activated protein/extracellular signal-regulated kinase kinase and other antiapoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xl) did not change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	183-186
16546963-8	2006	Treatment of cells with cerulenin and LY294002 down-regulated the protein levels of X chromosome-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis 1 (cIAP-1), and Akt, whereas the levels of mitogen-activated protein/extracellular signal-regulated kinase kinase and other antiapoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xl) did not change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	BCL2 apoptosis regulator	Homo sapiens	305-310
16546963-8	2006	Treatment of cells with cerulenin and LY294002 down-regulated the protein levels of X chromosome-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis 1 (cIAP-1), and Akt, whereas the levels of mitogen-activated protein/extracellular signal-regulated kinase kinase and other antiapoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xl) did not change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	BCL2 apoptosis regulator	Homo sapiens	328-333
16546963-8	2006	Treatment of cells with cerulenin and LY294002 down-regulated the protein levels of X chromosome-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis 1 (cIAP-1), and Akt, whereas the levels of mitogen-activated protein/extracellular signal-regulated kinase kinase and other antiapoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xl) did not change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	BCL2 like 1	Homo sapiens	338-344
16546963-9	2006	Interestingly, the nonspecific caspase inhibitor, z-VAD-FMK, inhibited the down-regulation of Akt, XIAP, and cIAP-1 in cerulenin- and LY294002-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	AKT serine/threonine kinase 1	Homo sapiens	94-97
16546963-9	2006	Interestingly, the nonspecific caspase inhibitor, z-VAD-FMK, inhibited the down-regulation of Akt, XIAP, and cIAP-1 in cerulenin- and LY294002-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	X-linked inhibitor of apoptosis	Homo sapiens	99-103
16546963-9	2006	Interestingly, the nonspecific caspase inhibitor, z-VAD-FMK, inhibited the down-regulation of Akt, XIAP, and cIAP-1 in cerulenin- and LY294002-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	baculoviral IAP repeat containing 2	Homo sapiens	109-115
16371352-3	2006	We have now shown that inhibition of phosphatidylinositol 3-kinase by LY294002 suppresses both basal and phorbol myristate acetate-induced COX-2 expression in TMK-1 and MKN-28 gastric cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	139-144
16477012-6	2006	The effects of PDGF/IL-1beta costimulation on contractile marker expression and Akt and p70S6K phosphorylation were blocked by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 and by adenovirus expressing a dominant-negative Akt, and they were mimicked by constitutively active Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	interleukin 1 beta	Homo sapiens	20-28
16477012-6	2006	The effects of PDGF/IL-1beta costimulation on contractile marker expression and Akt and p70S6K phosphorylation were blocked by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 and by adenovirus expressing a dominant-negative Akt, and they were mimicked by constitutively active Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	AKT serine/threonine kinase 1	Homo sapiens	80-83
16477012-6	2006	The effects of PDGF/IL-1beta costimulation on contractile marker expression and Akt and p70S6K phosphorylation were blocked by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 and by adenovirus expressing a dominant-negative Akt, and they were mimicked by constitutively active Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	ribosomal protein S6 kinase B1	Homo sapiens	88-94
16477012-6	2006	The effects of PDGF/IL-1beta costimulation on contractile marker expression and Akt and p70S6K phosphorylation were blocked by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 and by adenovirus expressing a dominant-negative Akt, and they were mimicked by constitutively active Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	AKT serine/threonine kinase 1	Homo sapiens	245-248
16477012-6	2006	The effects of PDGF/IL-1beta costimulation on contractile marker expression and Akt and p70S6K phosphorylation were blocked by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 and by adenovirus expressing a dominant-negative Akt, and they were mimicked by constitutively active Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	AKT serine/threonine kinase 1	Homo sapiens	245-248
16337154-7	2006	Blocking PI3-kinase by wortmannin or LY294002 reduced the PARP inhibitor-elicited robust Akt and GSK-3beta phosphorylation upon ischemia-reperfusion, and significantly diminished the recovery of ATP and creatine phosphate showing the importance of Akt activation in the recovery of energy metabolism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	poly(ADP-ribose) polymerase 1	Homo sapiens	58-62
16489044-0	2006	Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	activating transcription factor 3	Homo sapiens	0-33
16489044-0	2006	Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	early growth response 1	Homo sapiens	38-61
16489044-0	2006	Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	101-130
16489044-1	2006	LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, has been widely used to study the function of PI3K in cellular responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	12-41
16489044-3	2006	Here, we report that LY294002 alters early growth response 1 (EGR-1) phosphorylation and subsequently enhances activating transcription factor 3 (ATF3) expression independently of PI3K inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	early growth response 1	Homo sapiens	37-60
16489044-3	2006	Here, we report that LY294002 alters early growth response 1 (EGR-1) phosphorylation and subsequently enhances activating transcription factor 3 (ATF3) expression independently of PI3K inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	early growth response 1	Homo sapiens	62-67
16489044-3	2006	Here, we report that LY294002 alters early growth response 1 (EGR-1) phosphorylation and subsequently enhances activating transcription factor 3 (ATF3) expression independently of PI3K inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	activating transcription factor 3	Homo sapiens	111-144
16489044-3	2006	Here, we report that LY294002 alters early growth response 1 (EGR-1) phosphorylation and subsequently enhances activating transcription factor 3 (ATF3) expression independently of PI3K inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	activating transcription factor 3	Homo sapiens	146-150
16489044-5	2006	ATF3 expression was increased by LY294002, followed by the induction of apoptosis in several colorectal cancer cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	activating transcription factor 3	Homo sapiens	0-4
16489044-6	2006	This is consistent with results showing that the down-regulation of the ATF3 gene by small interfering RNA suppressed LY294002-induced apoptosis in HCT-116 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	activating transcription factor 3	Homo sapiens	72-76
16337154-7	2006	Blocking PI3-kinase by wortmannin or LY294002 reduced the PARP inhibitor-elicited robust Akt and GSK-3beta phosphorylation upon ischemia-reperfusion, and significantly diminished the recovery of ATP and creatine phosphate showing the importance of Akt activation in the recovery of energy metabolism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	89-92
16489044-8	2006	We also found that LY294002 increases ATF3 promoter activity and the transactivation is partly mediated by a GC-rich sequence located in the promoter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	activating transcription factor 3	Homo sapiens	38-42
16489044-10	2006	Furthermore, phosphorylated EGR-1 was highly increased in LY294002-treated cells, indicating that EGR-1 phosphorylation induced by LY294002 may facilitate ATF3 transactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	early growth response 1	Homo sapiens	28-33
16337154-7	2006	Blocking PI3-kinase by wortmannin or LY294002 reduced the PARP inhibitor-elicited robust Akt and GSK-3beta phosphorylation upon ischemia-reperfusion, and significantly diminished the recovery of ATP and creatine phosphate showing the importance of Akt activation in the recovery of energy metabolism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	glycogen synthase kinase 3 beta	Homo sapiens	97-106
16489044-10	2006	Furthermore, phosphorylated EGR-1 was highly increased in LY294002-treated cells, indicating that EGR-1 phosphorylation induced by LY294002 may facilitate ATF3 transactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	early growth response 1	Homo sapiens	98-103
16489044-10	2006	Furthermore, phosphorylated EGR-1 was highly increased in LY294002-treated cells, indicating that EGR-1 phosphorylation induced by LY294002 may facilitate ATF3 transactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	activating transcription factor 3	Homo sapiens	155-159
16337154-7	2006	Blocking PI3-kinase by wortmannin or LY294002 reduced the PARP inhibitor-elicited robust Akt and GSK-3beta phosphorylation upon ischemia-reperfusion, and significantly diminished the recovery of ATP and creatine phosphate showing the importance of Akt activation in the recovery of energy metabolism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	248-251
16489044-10	2006	Furthermore, phosphorylated EGR-1 was highly increased in LY294002-treated cells, indicating that EGR-1 phosphorylation induced by LY294002 may facilitate ATF3 transactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	early growth response 1	Homo sapiens	28-33
15842198-10	2006	LY-294002, an inhibitor of phosphoinositide 3-kinase-PKB signalling, suppressed activation of PKB and CDK1 as well as resumption of meiosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	thymoma viral proto-oncogene 1	Mus musculus	53-56
16489044-10	2006	Furthermore, phosphorylated EGR-1 was highly increased in LY294002-treated cells, indicating that EGR-1 phosphorylation induced by LY294002 may facilitate ATF3 transactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	early growth response 1	Homo sapiens	98-103
16489044-10	2006	Furthermore, phosphorylated EGR-1 was highly increased in LY294002-treated cells, indicating that EGR-1 phosphorylation induced by LY294002 may facilitate ATF3 transactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	activating transcription factor 3	Homo sapiens	155-159
16489044-11	2006	Our data suggest that EGR-1 acts as a mediator in LY294002-induced ATF3 expression via a PI3K-independent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	early growth response 1	Homo sapiens	22-27
16489044-11	2006	Our data suggest that EGR-1 acts as a mediator in LY294002-induced ATF3 expression via a PI3K-independent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	activating transcription factor 3	Homo sapiens	67-71
16489044-12	2006	ATF3 and EGR-1 may provide a novel explanation for the antitumorigenic properties of LY294002 in human colorectal cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	activating transcription factor 3	Homo sapiens	0-4
16489044-12	2006	ATF3 and EGR-1 may provide a novel explanation for the antitumorigenic properties of LY294002 in human colorectal cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	early growth response 1	Homo sapiens	9-14
16378598-3	2006	Although a PI3 kinase inhibitor, LY294002, by itself does not induce apoptotic cell death, LY294002 selectively and markedly enhances the apoptosis-inducing efficacy of doxorubicin: such an enhanced cell death is only detected in tumor cells in which the PI3 kinase/Akt pathway is constitutively activated, and it is totally dependent on the functional p53 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	AKT serine/threonine kinase 1	Homo sapiens	266-269
16378598-3	2006	Although a PI3 kinase inhibitor, LY294002, by itself does not induce apoptotic cell death, LY294002 selectively and markedly enhances the apoptosis-inducing efficacy of doxorubicin: such an enhanced cell death is only detected in tumor cells in which the PI3 kinase/Akt pathway is constitutively activated, and it is totally dependent on the functional p53 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	tumor protein p53	Homo sapiens	353-356
16427636-4	2006	Upon transfection of a RELMbeta encoding expression plasmid into these cells, we observed significant induction of proliferation particularly in SMC and A549 cells, which could be blocked by phosphatidyl-inositol 3-kinase (PI3K) inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	240-248	resistin like beta	Homo sapiens	23-31
15842198-10	2006	LY-294002, an inhibitor of phosphoinositide 3-kinase-PKB signalling, suppressed activation of PKB and CDK1 as well as resumption of meiosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	thymoma viral proto-oncogene 1	Mus musculus	94-97
15842198-10	2006	LY-294002, an inhibitor of phosphoinositide 3-kinase-PKB signalling, suppressed activation of PKB and CDK1 as well as resumption of meiosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	cyclin-dependent kinase 1	Mus musculus	102-106
16542871-3	2006	Insulin-induced down-regulation of apoM was blocked by AG1024 (a specific insulin receptor inhibitor) and LY294002 (a phosphatidylinositol 3-kinase (PI3K) inhibitor), which indicates that it is mediated via the activation of PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	insulin	Homo sapiens	0-7
16542871-3	2006	Insulin-induced down-regulation of apoM was blocked by AG1024 (a specific insulin receptor inhibitor) and LY294002 (a phosphatidylinositol 3-kinase (PI3K) inhibitor), which indicates that it is mediated via the activation of PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	apolipoprotein M	Homo sapiens	35-39
16479173-5	2006	Treatment of HL60 cells with PI3K inhibitors LY294002 and Wortmannin, which decrease the activity of the AKT pathway, induced apoptosis, but this effect was reduced in cells simultaneously treated with 1,25D.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	105-108
16412023-5	2006	The PI(3)K inhibitor LY294002 demonstrated antiproliferative effects in a dose- and time-dependent manner, which was associated with Akt dephosphorylation on Thr308 and Ser473 sites and dephosphorylation of the downstream ribosomal protein S6.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	133-136
16452192-9	2006	EGF-stimulated CXCL1 levels were variably decreased by mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase kinase and p38 MAPK inhibition in the five cell lines, but only LY294002 fully reversed the EGF effect in all cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	epidermal growth factor	Homo sapiens	0-3
16452192-9	2006	EGF-stimulated CXCL1 levels were variably decreased by mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase kinase and p38 MAPK inhibition in the five cell lines, but only LY294002 fully reversed the EGF effect in all cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	epidermal growth factor	Homo sapiens	225-228
16452198-10	2006	LY294002 also significantly inhibited the arachidonic acid-induced gene expression of COX-2, IL-1beta, GM-CSF, and ICAM1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
16452198-10	2006	LY294002 also significantly inhibited the arachidonic acid-induced gene expression of COX-2, IL-1beta, GM-CSF, and ICAM1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 beta	Homo sapiens	93-101
16479173-6	2006	Interestingly, LY294002 and Wortmannin also accentuated the 1,25D-induced G(1) to S phase cell cycle block in HL60 cells, and this was associated with an increased expression of p27Kip1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cyclin dependent kinase inhibitor 1B	Homo sapiens	178-185
16452198-10	2006	LY294002 also significantly inhibited the arachidonic acid-induced gene expression of COX-2, IL-1beta, GM-CSF, and ICAM1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	colony stimulating factor 2	Homo sapiens	103-109
16452198-10	2006	LY294002 also significantly inhibited the arachidonic acid-induced gene expression of COX-2, IL-1beta, GM-CSF, and ICAM1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	intercellular adhesion molecule 1	Homo sapiens	115-120
16461932-8	2006	LY294002, a specific inhibitor of phosphoinositide 3-kinase, was able to counteract the effect of anti-CD9 mAb and AS-CD9 on outgrowth ability and production of MMP-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CD9 antigen	Mus musculus	103-106
16461932-8	2006	LY294002, a specific inhibitor of phosphoinositide 3-kinase, was able to counteract the effect of anti-CD9 mAb and AS-CD9 on outgrowth ability and production of MMP-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CD9 antigen	Mus musculus	118-121
16461932-8	2006	LY294002, a specific inhibitor of phosphoinositide 3-kinase, was able to counteract the effect of anti-CD9 mAb and AS-CD9 on outgrowth ability and production of MMP-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	matrix metallopeptidase 2	Mus musculus	161-166
16474208-6	2006	NE-induced JNK phosphorylation was significantly inhibited by SP600125 and the conventional-type PKC (cPKC) inhibitor Go6976, but not by the Rho kinase inhibitor Y27632 or the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	216-224	mitogen-activated protein kinase 8	Rattus norvegicus	11-14
15869794-3	2006	In this study, we demonstrate the upregulation of c-Src in Raw264.7 and peritoneal macrophages (PEMs) by LPS, which is inhibited by PP2 (an inhibitor for Src family kinases), pyrrolidinedithiocarbamate (PDTC; NF-kappaB inhibitor) and LY294002 (PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	50-55
15869794-3	2006	In this study, we demonstrate the upregulation of c-Src in Raw264.7 and peritoneal macrophages (PEMs) by LPS, which is inhibited by PP2 (an inhibitor for Src family kinases), pyrrolidinedithiocarbamate (PDTC; NF-kappaB inhibitor) and LY294002 (PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	52-55
16405968-4	2006	The Reg/ATF-2-induced cyclin D1 promoter activation was attenuated by PI(3)K inhibitors such as LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	activating transcription factor 2	Mus musculus	8-13
16405968-4	2006	The Reg/ATF-2-induced cyclin D1 promoter activation was attenuated by PI(3)K inhibitors such as LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	cyclin D1	Mus musculus	22-31
16287813-4	2006	We have also found that a mutant form of centaurin-alpha1 that is unable to bind PIP3 fails to induce ERK activation and that a phosphatidylinositol 3-kinase inhibitor LY294002 inhibits centaurin-alpha1-dependent ERK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	ArfGAP with dual PH domains 1	Homo sapiens	186-202
16287813-4	2006	We have also found that a mutant form of centaurin-alpha1 that is unable to bind PIP3 fails to induce ERK activation and that a phosphatidylinositol 3-kinase inhibitor LY294002 inhibits centaurin-alpha1-dependent ERK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	mitogen-activated protein kinase 1	Homo sapiens	213-216
16282323-6	2006	The PI3K inhibitor, LY294002, blocked IL-3-stimulated Akt activity and partially blocked Bim(EL) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	interleukin 3	Mus musculus	38-42
16282323-6	2006	The PI3K inhibitor, LY294002, blocked IL-3-stimulated Akt activity and partially blocked Bim(EL) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	thymoma viral proto-oncogene 1	Mus musculus	54-57
16282323-6	2006	The PI3K inhibitor, LY294002, blocked IL-3-stimulated Akt activity and partially blocked Bim(EL) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	BCL2-like 11 (apoptosis facilitator)	Mus musculus	89-92
16166744-10	2006	Incubation of cells with LY294002, PD098059, or U0126 abolished HIMF-induced Akt and ERK1/2 phosphorylation and suppressed HIMF-induced SP-B and SP-C production, whereas SB203580 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	thymoma viral proto-oncogene 1	Mus musculus	77-80
16166744-10	2006	Incubation of cells with LY294002, PD098059, or U0126 abolished HIMF-induced Akt and ERK1/2 phosphorylation and suppressed HIMF-induced SP-B and SP-C production, whereas SB203580 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	mitogen-activated protein kinase 3	Mus musculus	85-91
16166744-10	2006	Incubation of cells with LY294002, PD098059, or U0126 abolished HIMF-induced Akt and ERK1/2 phosphorylation and suppressed HIMF-induced SP-B and SP-C production, whereas SB203580 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	surfactant associated protein B	Mus musculus	136-140
16166744-10	2006	Incubation of cells with LY294002, PD098059, or U0126 abolished HIMF-induced Akt and ERK1/2 phosphorylation and suppressed HIMF-induced SP-B and SP-C production, whereas SB203580 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	sparse coat	Mus musculus	145-149
16914897-6	2006	In addition, activation of the MAPK/ ERK cascade by ATP was blocked in cells pretreated with wortmannin and LY294002, but not by U73122, BAPTA or a Ca(2+)-free medium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	mitogen-activated protein kinase 1	Homo sapiens	37-40
16249373-9	2006	DADLE stimulated phosphorylation of membrane-associated Akt; wortmannin and LY294002 ([2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]), specific inhibitors of PI3K, abolished the DADLE-induced phosphorylation of c-jun.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-135	AKT serine/threonine kinase 1	Homo sapiens	56-59
16249373-9	2006	DADLE stimulated phosphorylation of membrane-associated Akt; wortmannin and LY294002 ([2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]), specific inhibitors of PI3K, abolished the DADLE-induced phosphorylation of c-jun.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-135	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	215-220
16216231-8	2006	Wortmannin and LY294002 prevented both RPP improvement and decrease in LDH, CK, and TnI release in LP and PostC groups.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	troponin I3, cardiac type	Rattus norvegicus	84-87
16354768-8	2006	In addition, JAK2 inhibitor suppressed PA-induced Akt phosphorylation, and the Akt inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) blocked GAS activation (GAS contains a promoter that responds to PA), suggesting that PA-mediated JAK2 activation leads to phosphatidylinositol 3-kinase/Akt phosphorylation and STAT activation, and the subsequent translocation of STAT to the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-141	AKT serine/threonine kinase 1	Homo sapiens	79-82
16354768-8	2006	In addition, JAK2 inhibitor suppressed PA-induced Akt phosphorylation, and the Akt inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) blocked GAS activation (GAS contains a promoter that responds to PA), suggesting that PA-mediated JAK2 activation leads to phosphatidylinositol 3-kinase/Akt phosphorylation and STAT activation, and the subsequent translocation of STAT to the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-141	Janus kinase 2	Homo sapiens	251-255
16354768-8	2006	In addition, JAK2 inhibitor suppressed PA-induced Akt phosphorylation, and the Akt inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) blocked GAS activation (GAS contains a promoter that responds to PA), suggesting that PA-mediated JAK2 activation leads to phosphatidylinositol 3-kinase/Akt phosphorylation and STAT activation, and the subsequent translocation of STAT to the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-141	AKT serine/threonine kinase 1	Homo sapiens	79-82
16354768-8	2006	In addition, JAK2 inhibitor suppressed PA-induced Akt phosphorylation, and the Akt inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) blocked GAS activation (GAS contains a promoter that responds to PA), suggesting that PA-mediated JAK2 activation leads to phosphatidylinositol 3-kinase/Akt phosphorylation and STAT activation, and the subsequent translocation of STAT to the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	AKT serine/threonine kinase 1	Homo sapiens	79-82
16354768-8	2006	In addition, JAK2 inhibitor suppressed PA-induced Akt phosphorylation, and the Akt inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) blocked GAS activation (GAS contains a promoter that responds to PA), suggesting that PA-mediated JAK2 activation leads to phosphatidylinositol 3-kinase/Akt phosphorylation and STAT activation, and the subsequent translocation of STAT to the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	AKT serine/threonine kinase 1	Homo sapiens	79-82
16354769-6	2006	In all cases, induction was inhibited by pretreatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) or the p38 inhibitor 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB203580).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-158	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	63-92
16354769-6	2006	In all cases, induction was inhibited by pretreatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) or the p38 inhibitor 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB203580).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	63-92
17146146-1	2006	In the process of receptor-mediated endocytosis, the fusion of endosomes in vitro is known to be inhibited by wortmannin or LY294002; inhibitors of phosphoinositide 3-kinase (PI3K), suggesting that the activity of PI3K is required for the fusion of early endosomes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	148-173
16384957-9	2006	Western blot analysis showed that phosphorylation of Akt and FKHRL1was abolished by LY294002 and SR13668, but downregulated by U0126, which also abolished phosphorylation of p44/42 mitogen-activated protein kinase (MAPK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Homo sapiens	53-56
16253565-6	2006	The JNK inhibitor SP600125 and the PI3-kinase inhibitor LY294002 significantly blocked the poly(I:C)-induced release of RANTES and IL-8, whereas the p38 MAP kinase inhibitor SB203580 suppressed poly(I:C)-induced secretion of IL-8, but not RANTES.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	C-C motif chemokine ligand 5	Homo sapiens	120-126
16253565-6	2006	The JNK inhibitor SP600125 and the PI3-kinase inhibitor LY294002 significantly blocked the poly(I:C)-induced release of RANTES and IL-8, whereas the p38 MAP kinase inhibitor SB203580 suppressed poly(I:C)-induced secretion of IL-8, but not RANTES.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
16397049-0	2006	Phosphatidylinositol 3-kinase inhibition by LY294002 radiosensitizes human cervical cancer cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-29
16343977-7	2006	The phosphatidylinositol 3-kinase inhibitor LY 294002, also, inhibited epidermal growth factor-dependent DNA synthesis and Akt phosphorylation but did not decrease extracellular regulated kinases phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-53	AKT serine/threonine kinase 1	Homo sapiens	123-126
16384957-9	2006	Western blot analysis showed that phosphorylation of Akt and FKHRL1was abolished by LY294002 and SR13668, but downregulated by U0126, which also abolished phosphorylation of p44/42 mitogen-activated protein kinase (MAPK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	forkhead box O3	Homo sapiens	61-67
17341207-7	2006	When HT-1080 cells were treated with PI-3K inhibitor (LY294002) and grown in presence of fibronectin, MMP-2 activation was partially inhibited, but when cells were treated with ERK inhibitor (PD98059) and grown in presence of fibronectin, MMP-2 activation was almost completely inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	fibronectin 1	Homo sapiens	89-100
16410064-8	2006	From the results of casein zymography and ELISA, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha-stimulated t-PA production, respectively (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	interleukin 1 alpha	Homo sapiens	105-114
16410064-8	2006	From the results of casein zymography and ELISA, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha-stimulated t-PA production, respectively (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	plasminogen activator, tissue type	Homo sapiens	126-130
16410064-10	2006	SB203580, U0126, and LY294002 suppress t-PA activity and may also have important implication for pharmacological intervention.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	plasminogen activator, tissue type	Homo sapiens	39-43
16339173-8	2006	Using LY294002, an inhibitor of PI 3-kinase activity, we found that this activation is essential for E-cadherin connection with the cytoskeleton and for biogenesis of adherens junctions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	cadherin 1	Homo sapiens	101-111
16394177-3	2006	The BK-induced ERK1/2 phosphorylation was completely blocked by PD98059 (an inhibitor of the mitogen-activated protein kinase kinase (MAPKK or MEK)) and by LY294002 (an inhibitor of phosphoinositide 3-kinase (PI3K)), and was reduced by GF109203X (an inhibitor of both novel and conventional PKCs); Go6976, a conventional PKCs inhibitor, did not have any effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	mitogen-activated protein kinase 3	Homo sapiens	15-21
16394177-3	2006	The BK-induced ERK1/2 phosphorylation was completely blocked by PD98059 (an inhibitor of the mitogen-activated protein kinase kinase (MAPKK or MEK)) and by LY294002 (an inhibitor of phosphoinositide 3-kinase (PI3K)), and was reduced by GF109203X (an inhibitor of both novel and conventional PKCs); Go6976, a conventional PKCs inhibitor, did not have any effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	182-207
16394177-4	2006	The BK-induced phosphorylation of PKB/Akt was blocked by LY294002 but not by PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	34-37
16394177-4	2006	The BK-induced phosphorylation of PKB/Akt was blocked by LY294002 but not by PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	38-41
17341207-7	2006	When HT-1080 cells were treated with PI-3K inhibitor (LY294002) and grown in presence of fibronectin, MMP-2 activation was partially inhibited, but when cells were treated with ERK inhibitor (PD98059) and grown in presence of fibronectin, MMP-2 activation was almost completely inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	matrix metallopeptidase 2	Homo sapiens	102-107
17341207-7	2006	When HT-1080 cells were treated with PI-3K inhibitor (LY294002) and grown in presence of fibronectin, MMP-2 activation was partially inhibited, but when cells were treated with ERK inhibitor (PD98059) and grown in presence of fibronectin, MMP-2 activation was almost completely inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	mitogen-activated protein kinase 1	Homo sapiens	177-180
17341207-7	2006	When HT-1080 cells were treated with PI-3K inhibitor (LY294002) and grown in presence of fibronectin, MMP-2 activation was partially inhibited, but when cells were treated with ERK inhibitor (PD98059) and grown in presence of fibronectin, MMP-2 activation was almost completely inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	fibronectin 1	Homo sapiens	226-237
17341207-7	2006	When HT-1080 cells were treated with PI-3K inhibitor (LY294002) and grown in presence of fibronectin, MMP-2 activation was partially inhibited, but when cells were treated with ERK inhibitor (PD98059) and grown in presence of fibronectin, MMP-2 activation was almost completely inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	matrix metallopeptidase 2	Homo sapiens	239-244
16323212-7	2006	Furthermore, the addition of the phosphatidylinositol 3-kinase pathway specific inhibitor (LY294002) blocked GDNF-mediated striatal cell differentiation suggesting that the basal activity of this pathway is needed for the effects of GDNF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	glial cell derived neurotrophic factor	Homo sapiens	109-113
16300633-0	2006	NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor, LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3beta-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	glycogen synthase kinase 3 beta	Rattus norvegicus	113-143
16323212-7	2006	Furthermore, the addition of the phosphatidylinositol 3-kinase pathway specific inhibitor (LY294002) blocked GDNF-mediated striatal cell differentiation suggesting that the basal activity of this pathway is needed for the effects of GDNF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	glial cell derived neurotrophic factor	Homo sapiens	233-237
16300633-4	2006	NMDA at 10 microm suppressed LY294002-induced activation of a pro-apoptotic kinase, glycogen synthase kinase 3beta (GSK3beta).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	glycogen synthase kinase 3 beta	Rattus norvegicus	84-114
16300633-0	2006	NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor, LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3beta-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	84-88
16360265-6	2006	Two structurally unrelated phosphoinositide 3-Kinase (PI3K, upstream of PKB/Akt) inhibitors, Wortmannin and LY294002, also prevented the mechanical hypersensitivity induced by intradermal injection of capsaicin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	27-52
16272825-6	2006	Furthermore, by blocking PI3K phosphorylation using the specific inhibitor, LY294002, we found that downstream phosphorylation of AKT-1 was inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Gallus gallus	130-135
16272825-7	2006	More importantly, the blockade of the PI3K pathway via LY294002 in sp-FGF-1-transfected CAMs significantly inhibited angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	fibroblast growth factor 1	Gallus gallus	70-75
16267832-3	2006	Because the heat shock protein (HSP) is involved in the conformational maturation of a number of signaling proteins critical to the proliferation of malignant glioma cells, we hypothesized that the combination of the PI3K inhibitor LY294002 and the HSP90 inhibitor 17-allyl-aminogeldanamycin (17-AAG) would promote glioma cytotoxicity by decreasing both the activation status and levels of Akt, as well as downregulating the levels of other relevant signaling effectors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	232-240	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	12-30
16267832-3	2006	Because the heat shock protein (HSP) is involved in the conformational maturation of a number of signaling proteins critical to the proliferation of malignant glioma cells, we hypothesized that the combination of the PI3K inhibitor LY294002 and the HSP90 inhibitor 17-allyl-aminogeldanamycin (17-AAG) would promote glioma cytotoxicity by decreasing both the activation status and levels of Akt, as well as downregulating the levels of other relevant signaling effectors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	232-240	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	32-35
16267832-6	2006	Quantitative analysis revealed that enhancement by LY294002 of 17-AAG-induced cytotoxicity was synergistic, leading to a pronounced increase in active caspase-3 and poly (adenosine diphosphate-ribose) polymerase (PARP) cleavage together with the release of cytochrome c and apoptosis inducing factor (AIF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	caspase 3	Homo sapiens	151-160
16267832-6	2006	Quantitative analysis revealed that enhancement by LY294002 of 17-AAG-induced cytotoxicity was synergistic, leading to a pronounced increase in active caspase-3 and poly (adenosine diphosphate-ribose) polymerase (PARP) cleavage together with the release of cytochrome c and apoptosis inducing factor (AIF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	poly(ADP-ribose) polymerase 1	Homo sapiens	213-217
16267832-6	2006	Quantitative analysis revealed that enhancement by LY294002 of 17-AAG-induced cytotoxicity was synergistic, leading to a pronounced increase in active caspase-3 and poly (adenosine diphosphate-ribose) polymerase (PARP) cleavage together with the release of cytochrome c and apoptosis inducing factor (AIF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	cytochrome c, somatic	Homo sapiens	257-269
16267832-6	2006	Quantitative analysis revealed that enhancement by LY294002 of 17-AAG-induced cytotoxicity was synergistic, leading to a pronounced increase in active caspase-3 and poly (adenosine diphosphate-ribose) polymerase (PARP) cleavage together with the release of cytochrome c and apoptosis inducing factor (AIF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	apoptosis inducing factor mitochondria associated 1	Homo sapiens	274-299
16267832-6	2006	Quantitative analysis revealed that enhancement by LY294002 of 17-AAG-induced cytotoxicity was synergistic, leading to a pronounced increase in active caspase-3 and poly (adenosine diphosphate-ribose) polymerase (PARP) cleavage together with the release of cytochrome c and apoptosis inducing factor (AIF).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	apoptosis inducing factor mitochondria associated 1	Homo sapiens	301-304
16267832-10	2006	Cells exposed to 17-AAG and LY294002 displayed a significant reduction in cell-cycle regulatory proteins, such as retinoblastoma (Rb), cyclin dependent kinase (CDK)4, CDK6, cyclin D1, and cyclin D3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin dependent kinase 4	Homo sapiens	160-165
16267832-10	2006	Cells exposed to 17-AAG and LY294002 displayed a significant reduction in cell-cycle regulatory proteins, such as retinoblastoma (Rb), cyclin dependent kinase (CDK)4, CDK6, cyclin D1, and cyclin D3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin dependent kinase 6	Homo sapiens	167-171
16267832-10	2006	Cells exposed to 17-AAG and LY294002 displayed a significant reduction in cell-cycle regulatory proteins, such as retinoblastoma (Rb), cyclin dependent kinase (CDK)4, CDK6, cyclin D1, and cyclin D3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin D1	Homo sapiens	173-182
16267832-10	2006	Cells exposed to 17-AAG and LY294002 displayed a significant reduction in cell-cycle regulatory proteins, such as retinoblastoma (Rb), cyclin dependent kinase (CDK)4, CDK6, cyclin D1, and cyclin D3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin D3	Homo sapiens	188-197
16300633-4	2006	NMDA at 10 microm suppressed LY294002-induced activation of a pro-apoptotic kinase, glycogen synthase kinase 3beta (GSK3beta).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	glycogen synthase kinase 3 beta	Rattus norvegicus	116-124
16300633-5	2006	GSK3beta activation by LY294002 was associated with decreased levels of inhibitory GSK3beta phosphorylation at the Ser9 residue.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	glycogen synthase kinase 3 beta	Rattus norvegicus	0-8
16300633-5	2006	GSK3beta activation by LY294002 was associated with decreased levels of inhibitory GSK3beta phosphorylation at the Ser9 residue.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	glycogen synthase kinase 3 beta	Rattus norvegicus	83-91
16352547-4	2006	In contrast, treatment of cells with LY294002, an inhibitor of the phosphoinositide 3-kinase (PI3 kinase) family, prevents the induction of interferon-stimulated gene 56 (ISG56) and an antiviral response upon entry of virus particles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	171-176
16352547-6	2006	Furthermore, DNA-PK and PAK1, LY294002-sensitive members of the PI3 kinase family shown previously to be involved in IRF-3 activation, are also dispensable for ISG and antiviral state induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	interferon regulatory factor 3	Homo sapiens	117-122
16785763-6	2006	RESULTS: LY294002 suppressed cell proliferation but induced apoptosis with decreased levels of phosphorylated Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	110-113
16785763-7	2006	HIF-1alpha expression and VEGF secretion were induced under hypoxic conditions and VEGF protein secretion was significantly decreased by treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
16785763-7	2006	HIF-1alpha expression and VEGF secretion were induced under hypoxic conditions and VEGF protein secretion was significantly decreased by treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	vascular endothelial growth factor A	Homo sapiens	26-30
16360265-6	2006	Two structurally unrelated phosphoinositide 3-Kinase (PI3K, upstream of PKB/Akt) inhibitors, Wortmannin and LY294002, also prevented the mechanical hypersensitivity induced by intradermal injection of capsaicin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Rattus norvegicus	76-79
16785763-7	2006	HIF-1alpha expression and VEGF secretion were induced under hypoxic conditions and VEGF protein secretion was significantly decreased by treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	vascular endothelial growth factor A	Homo sapiens	83-87
16123382-6	2006	The downstream effectors of mTOR, p70 S6 kinase (S6K) and 4E-binding protein 1 (4E-BP1), are phosphorylated by TPO in a rapamycin- and LY294002-sensitive manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	mechanistic target of rapamycin kinase	Homo sapiens	28-32
16123382-6	2006	The downstream effectors of mTOR, p70 S6 kinase (S6K) and 4E-binding protein 1 (4E-BP1), are phosphorylated by TPO in a rapamycin- and LY294002-sensitive manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	58-78
16123382-6	2006	The downstream effectors of mTOR, p70 S6 kinase (S6K) and 4E-binding protein 1 (4E-BP1), are phosphorylated by TPO in a rapamycin- and LY294002-sensitive manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	80-86
16123382-6	2006	The downstream effectors of mTOR, p70 S6 kinase (S6K) and 4E-binding protein 1 (4E-BP1), are phosphorylated by TPO in a rapamycin- and LY294002-sensitive manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	thrombopoietin	Homo sapiens	111-114
16288728-4	2005	Addition of a PI-3 kinase inhibitor (LY294002) abrogated the stimulatory effect of TGF-beta1 on the telomerase activity, indicating the possible involvement of hTERT activation via phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	transforming growth factor beta 1	Homo sapiens	83-92
16288728-4	2005	Addition of a PI-3 kinase inhibitor (LY294002) abrogated the stimulatory effect of TGF-beta1 on the telomerase activity, indicating the possible involvement of hTERT activation via phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	telomerase reverse transcriptase	Homo sapiens	160-165
16297374-6	2005	CisPt provoked the phosphorylation of PKB/Akt and this effect was blocked by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Rattus norvegicus	38-45
15703956-7	2006	Activation of p38 mitogen activated protein (MAP) kinase and phosphatidylinositol 3-kinase (PI3K) by TNF-alpha was inhibited with SB202190 and Ly 294002 respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-152	mitogen-activated protein kinase 14	Homo sapiens	14-17
15703956-7	2006	Activation of p38 mitogen activated protein (MAP) kinase and phosphatidylinositol 3-kinase (PI3K) by TNF-alpha was inhibited with SB202190 and Ly 294002 respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-152	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	61-90
15703956-7	2006	Activation of p38 mitogen activated protein (MAP) kinase and phosphatidylinositol 3-kinase (PI3K) by TNF-alpha was inhibited with SB202190 and Ly 294002 respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-152	tumor necrosis factor	Homo sapiens	101-110
16297374-7	2005	In PC-Cl3 cells pre-incubated with LY294002 the effects of cisPt on ERK phosphorylation and cell mortality resulted unaffected; conversely, LY294002 reduced the ERK phosphorylation and increased cisPt cytotoxity of in PC-E1Araf cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	Eph receptor B1	Rattus norvegicus	161-164
16269654-10	2005	The inhibitory effect of adiponectin on TNF-alpha-induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection, suggesting that Akt activation might inhibit IL-8 synthesis induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	adiponectin, C1Q and collagen domain containing	Homo sapiens	25-36
16339563-6	2005	LPS-induced activation of p21Ras was inhibited in the presence of PP2, LY294002, or wortmannin, suggesting that it depends on the activity of one or more members of the Src kinase family and the subsequent activation of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	Harvey rat sarcoma virus oncogene	Mus musculus	26-32
16095815-3	2005	We also found that LY 294002, an inhibitor of phosphatidylinositol 3-kinase (PI 3-K), reduced the survival of cells treated with NGF for 24h in the presence of Th.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	46-75
16095815-3	2005	We also found that LY 294002, an inhibitor of phosphatidylinositol 3-kinase (PI 3-K), reduced the survival of cells treated with NGF for 24h in the presence of Th.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	nerve growth factor	Rattus norvegicus	129-132
16095815-5	2005	LY 294002 diminished the effect of NGF on the inactivation of all these caspases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	nerve growth factor	Rattus norvegicus	35-38
16095815-5	2005	LY 294002 diminished the effect of NGF on the inactivation of all these caspases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	caspase 9	Rattus norvegicus	72-80
16269654-10	2005	The inhibitory effect of adiponectin on TNF-alpha-induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection, suggesting that Akt activation might inhibit IL-8 synthesis induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	tumor necrosis factor	Homo sapiens	40-49
16269654-10	2005	The inhibitory effect of adiponectin on TNF-alpha-induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection, suggesting that Akt activation might inhibit IL-8 synthesis induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
16269654-10	2005	The inhibitory effect of adiponectin on TNF-alpha-induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection, suggesting that Akt activation might inhibit IL-8 synthesis induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Homo sapiens	196-199
16269654-10	2005	The inhibitory effect of adiponectin on TNF-alpha-induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection, suggesting that Akt activation might inhibit IL-8 synthesis induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	C-X-C motif chemokine ligand 8	Homo sapiens	225-229
16269654-10	2005	The inhibitory effect of adiponectin on TNF-alpha-induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection, suggesting that Akt activation might inhibit IL-8 synthesis induced by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	tumor necrosis factor	Homo sapiens	251-260
15933740-0	2005	The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	tumor protein p53	Homo sapiens	37-40
16123394-9	2005	Apoptotic resistance of mesothelioma cells was significantly reduced by inhibiting either the PI3K/Akt pathway with LY294002 (47 +/- 6% apoptosis) or the mTOR pathway with rapamycin (50 +/- 17% apoptosis).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	99-102
15933740-5	2005	We report here that exposure to LY294002, a potent PI3K inhibitor, aborts the activation of p53 by several drugs commonly used in cancer chemotherapy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	tumor protein p53	Homo sapiens	92-95
16098957-9	2005	MAP kinase kinase (MEK)1/2 inhibitor U0126, phosphatidylinositol (PI) 3-kinase inhibitors (wortmannin and LY294002), and dominant negative Akt mutant significantly prevented stretch-induced SMC proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	AKT serine/threonine kinase 1	Homo sapiens	139-142
15933740-6	2005	Concomitantly, LY294002 attenuates p53-dependent, chemotherapy-induced apoptosis of cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	tumor protein p53	Homo sapiens	35-38
15997243-6	2005	Furthermore, we show that the hypertrophic effect of leptin was mediated via PI 3-kinase and ERK1/2 by using the inhibitors LY294002 and PD98059, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	leptin	Rattus norvegicus	53-59
16322316-10	2005	Inhibition of PKB phosphorylation by LY294002 in the PC3 and MCF10CA1 tumor cell lines similarly failed to result in a significant increase in apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	chromobox 8	Homo sapiens	53-56
16322316-11	2005	CONCLUSIONS: Our results show that inhibition of PI3K/PKB signaling by indole-3-carbinol or LY294002 is not directly correlated with induction of apoptosis in several breast or prostate cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	protein tyrosine kinase 2 beta	Homo sapiens	54-57
16322316-7	2005	First, 50% inhibition of PKB phosphorylation by LY294002 resulted in only 15% apoptosis after 72 hours, whereas similar PKB inhibition by indole-3-carbinol coincided with 30% apoptosis after only 24 hours.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	protein tyrosine kinase 2 beta	Homo sapiens	25-28
16322316-10	2005	Inhibition of PKB phosphorylation by LY294002 in the PC3 and MCF10CA1 tumor cell lines similarly failed to result in a significant increase in apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	protein tyrosine kinase 2 beta	Homo sapiens	14-17
15997243-6	2005	Furthermore, we show that the hypertrophic effect of leptin was mediated via PI 3-kinase and ERK1/2 by using the inhibitors LY294002 and PD98059, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	mitogen activated protein kinase 3	Rattus norvegicus	93-99
16139919-4	2005	RESULTS: The phophatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the mitogen-activated protein kinase inhibitor, UO126, decreased the TGF-beta1-dependent ADAM12 expression and prevented the phosphorylation of p70S6K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	13-41
16303940-10	2005	LY294002 (a specific PI 3-kinase inhibitor) greatly reduced the steady state levels and stability of alpha1(I) and alpha2(I) collagen RNAs and the secretion of type I collagen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	collagen type I alpha 2 chain	Homo sapiens	115-133
16139919-4	2005	RESULTS: The phophatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the mitogen-activated protein kinase inhibitor, UO126, decreased the TGF-beta1-dependent ADAM12 expression and prevented the phosphorylation of p70S6K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	transforming growth factor beta 1	Homo sapiens	141-150
16139919-4	2005	RESULTS: The phophatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the mitogen-activated protein kinase inhibitor, UO126, decreased the TGF-beta1-dependent ADAM12 expression and prevented the phosphorylation of p70S6K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	ADAM metallopeptidase domain 12	Homo sapiens	161-167
16162944-5	2005	Induction of SREBP-1, SCD-1, and FAS by KGF was inhibited by the JNK inhibitor SP600125 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 but not by the ERK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	sterol regulatory element binding transcription factor 1	Homo sapiens	13-20
16162944-5	2005	Induction of SREBP-1, SCD-1, and FAS by KGF was inhibited by the JNK inhibitor SP600125 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 but not by the ERK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	fibroblast growth factor 7	Homo sapiens	40-43
16139919-4	2005	RESULTS: The phophatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the mitogen-activated protein kinase inhibitor, UO126, decreased the TGF-beta1-dependent ADAM12 expression and prevented the phosphorylation of p70S6K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	ribosomal protein S6 kinase B1	Homo sapiens	216-222
16139919-6	2005	In untreated cells, LY294002 but not rapamycin diminished the basal ADAM12 expression related to inhibition of Akt and the glycogen synthase kinase-3 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	ADAM metallopeptidase domain 12	Homo sapiens	68-74
16139919-6	2005	In untreated cells, LY294002 but not rapamycin diminished the basal ADAM12 expression related to inhibition of Akt and the glycogen synthase kinase-3 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	111-114
16326831-1	2005	Insulin-like growth factor-I (IGF-I) is a mitogenic polypeptide that induces proliferation of MCF-7 breast cancer cells, and cotreatment with the phosphoinositide 3-kinase (PI3-K) inhibitor LY294002 and the antiestrogen ICI 182780 inhibits IGF-I-induced growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	insulin like growth factor 1	Homo sapiens	0-28
16277616-7	2005	The PI3K inhibitors, LY294002 and wortmannin, blocked the DHPG-induced increased phosphorylation of Akt and Gsk3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Rattus norvegicus	100-103
16277616-7	2005	The PI3K inhibitors, LY294002 and wortmannin, blocked the DHPG-induced increased phosphorylation of Akt and Gsk3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	glycogen synthase kinase 3 beta	Rattus norvegicus	108-116
16326831-1	2005	Insulin-like growth factor-I (IGF-I) is a mitogenic polypeptide that induces proliferation of MCF-7 breast cancer cells, and cotreatment with the phosphoinositide 3-kinase (PI3-K) inhibitor LY294002 and the antiestrogen ICI 182780 inhibits IGF-I-induced growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	insulin like growth factor 1	Homo sapiens	30-35
16326831-1	2005	Insulin-like growth factor-I (IGF-I) is a mitogenic polypeptide that induces proliferation of MCF-7 breast cancer cells, and cotreatment with the phosphoinositide 3-kinase (PI3-K) inhibitor LY294002 and the antiestrogen ICI 182780 inhibits IGF-I-induced growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	146-171
16343111-3	2005	Furthermore, to search for possible signal transduction pathways, SB203580, U0126 and LY294002 were added to test how they modulated the t-PA activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	plasminogen activator, tissue type	Homo sapiens	137-141
16144975-8	2005	The phosphoinositide 3-kinase (PI3K)-Akt blocker 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002) reversed the protective effects of galantamine, donepezil, and nicotine but not that of rivastigmine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Homo sapiens	37-40
16150885-5	2005	Tsc2 expression increased the susceptibility of ERC-18 cells to apoptosis induced by OKA and the phosphatidylinositol-3" kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	TSC complex subunit 2	Homo sapiens	0-4
16282450-6	2005	Inhibition of the phosphoinositide-3-OH kinase/Akt pathway by Wortmannin or Ly294002 compounds decreased Ad vector induction of CXCL10 mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	AKT serine/threonine kinase 1	Homo sapiens	47-50
16282450-6	2005	Inhibition of the phosphoinositide-3-OH kinase/Akt pathway by Wortmannin or Ly294002 compounds decreased Ad vector induction of CXCL10 mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	C-X-C motif chemokine ligand 10	Homo sapiens	128-134
16282450-8	2005	The effect of Akt on CXCL10 mRNA expression occurred via NFkappaB-dependent transcriptional activation, since AktAAA overexpression and Ly294002 both inhibited CXCL10 and NFkappaB promoter activation in luciferase reporter experiments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	C-X-C motif chemokine ligand 10	Homo sapiens	21-27
16282450-8	2005	The effect of Akt on CXCL10 mRNA expression occurred via NFkappaB-dependent transcriptional activation, since AktAAA overexpression and Ly294002 both inhibited CXCL10 and NFkappaB promoter activation in luciferase reporter experiments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	C-X-C motif chemokine ligand 10	Homo sapiens	160-166
16282450-8	2005	The effect of Akt on CXCL10 mRNA expression occurred via NFkappaB-dependent transcriptional activation, since AktAAA overexpression and Ly294002 both inhibited CXCL10 and NFkappaB promoter activation in luciferase reporter experiments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	nuclear factor kappa B subunit 1	Homo sapiens	171-179
16411407-8	2005	Cell exposure to PD98059 and LY294002 prevented homocysteine effects on MMP-2 synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	matrix metallopeptidase 2	Homo sapiens	72-77
16172130-4	2005	Akt activation was significantly inhibited by LY294002 and wortmannin, specific inhibitors of phosphatidylinositol 3-kinase, but not by H-89.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	0-3
16154532-4	2005	The PTEN-induced decrease in IGFBP-2 expression could be mimicked with the PI3-kinase inhibitor LY294002, indicating that the lipid phosphatase activity of PTEN is responsible for the observed effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	phosphatase and tensin homolog	Homo sapiens	4-8
16299254-13	2005	The data also show that LY294002 directly inhibits vascular endothelial growth factor (VEGF) protein expression and release from ovarian carcinoma and suggest that LY294002 blocks the VEGF signaling pathway involved in angiogenesis and vascular permeability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	vascular endothelial growth factor A	Mus musculus	51-85
16299254-13	2005	The data also show that LY294002 directly inhibits vascular endothelial growth factor (VEGF) protein expression and release from ovarian carcinoma and suggest that LY294002 blocks the VEGF signaling pathway involved in angiogenesis and vascular permeability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	vascular endothelial growth factor A	Mus musculus	87-91
16299254-13	2005	The data also show that LY294002 directly inhibits vascular endothelial growth factor (VEGF) protein expression and release from ovarian carcinoma and suggest that LY294002 blocks the VEGF signaling pathway involved in angiogenesis and vascular permeability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	vascular endothelial growth factor A	Mus musculus	51-85
16299254-13	2005	The data also show that LY294002 directly inhibits vascular endothelial growth factor (VEGF) protein expression and release from ovarian carcinoma and suggest that LY294002 blocks the VEGF signaling pathway involved in angiogenesis and vascular permeability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	vascular endothelial growth factor A	Mus musculus	87-91
16299254-13	2005	The data also show that LY294002 directly inhibits vascular endothelial growth factor (VEGF) protein expression and release from ovarian carcinoma and suggest that LY294002 blocks the VEGF signaling pathway involved in angiogenesis and vascular permeability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	vascular endothelial growth factor A	Mus musculus	184-188
16157221-5	2005	Moreover, hTnC-induced Akt activation was blocked by LY294002 and the expression of dominant-negative Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	tenascin C	Homo sapiens	10-14
16157221-5	2005	Moreover, hTnC-induced Akt activation was blocked by LY294002 and the expression of dominant-negative Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	23-26
16202975-3	2005	GM-CSF induced tube formation in human umbilical vein endothelial cells, as examined using Matrigel assay, was inhibited by specific inhibitors of PI3-kinase, wortmannin, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	colony stimulating factor 2	Homo sapiens	0-6
16253776-4	2005	To test the hypothesis that inhibition of PKB is responsible for LY294002-induced radiosensitivity, LNCaP cells expressing a constitutively active form of PKB were used.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	protein tyrosine kinase 2 beta	Homo sapiens	42-45
16253776-6	2005	The expression of constitutively activated PKB blocked apoptosis induced by combination of PI3K inhibition and radiation and prevented radiosensitization by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	protein tyrosine kinase 2 beta	Homo sapiens	43-46
16154532-4	2005	The PTEN-induced decrease in IGFBP-2 expression could be mimicked with the PI3-kinase inhibitor LY294002, indicating that the lipid phosphatase activity of PTEN is responsible for the observed effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	insulin like growth factor binding protein 2	Homo sapiens	29-36
16154532-4	2005	The PTEN-induced decrease in IGFBP-2 expression could be mimicked with the PI3-kinase inhibitor LY294002, indicating that the lipid phosphatase activity of PTEN is responsible for the observed effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	phosphatase and tensin homolog	Homo sapiens	156-160
16249673-11	2005	LY294002 inhibited isoflurane-induced phosphorylation of protein kinase B/Akt and glycogen synthase kinase 3beta and opened mPTP as determined by nicotinamide adenine dinucleotide measurements.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
16249673-11	2005	LY294002 inhibited isoflurane-induced phosphorylation of protein kinase B/Akt and glycogen synthase kinase 3beta and opened mPTP as determined by nicotinamide adenine dinucleotide measurements.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	82-112
16249673-11	2005	LY294002 inhibited isoflurane-induced phosphorylation of protein kinase B/Akt and glycogen synthase kinase 3beta and opened mPTP as determined by nicotinamide adenine dinucleotide measurements.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein tyrosine phosphatase, receptor type, U	Mus musculus	124-128
15859947-4	2005	RESULTS: By quantitative immunoblotting of purified hepatocyte plasma membranes, we found that the preincubation of cells with two structurally different PI3K inhibitors, wortmannin or LY294002, prevented the glucagon-induced translocation of AQP8 to hepatocyte plasma membrane.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	aquaporin 8	Homo sapiens	243-247
16218998-7	2005	Furthermore, inhibition of Akt activation by LY294002 treatment did not inhibit GHRP-6 induction of NPY or IGF-I synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Rattus norvegicus	27-30
16004602-9	2005	The secretion of PSA was partially inhibited in the presence of LY294002, while the secretion of PSAP was completely abolished by the PI3K (phosphoinositide 3-kinase) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	kallikrein related peptidase 3	Homo sapiens	17-20
15887250-10	2005	Additionally, the effect of Ang II on Na+/K+ATPase activity was also blocked by the phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin and LY294002, and by the actin depolymerizing agents, cytochalasin D.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	angiogenin	Homo sapiens	28-31
16171808-10	2005	The protective effect of T3 on cell viability, DNA laddering and TUNEL positive cells were blocked by LY294002, a phosphoinositide-3 kinase (PI3K) inhibitor that blocks Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	AKT serine/threonine kinase 1	Rattus norvegicus	169-172
16267010-14	2005	Additional studies showed that the PI3K/AKT-specific inhibitor LY294002 had a more profound effect than the MAPK-specific inhibitor U0126 in blocking EGF-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	AKT serine/threonine kinase 1	Homo sapiens	40-43
16267010-14	2005	Additional studies showed that the PI3K/AKT-specific inhibitor LY294002 had a more profound effect than the MAPK-specific inhibitor U0126 in blocking EGF-induced cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	epidermal growth factor	Homo sapiens	150-153
16211241-6	2005	Paclitaxel-induced ERK and AKT activity was inhibited by the EGFR inhibitor, PD153035; ERK inhibitor, U0126; and PI3 kinase inhibitor, LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	mitogen-activated protein kinase 1	Homo sapiens	19-22
16211241-6	2005	Paclitaxel-induced ERK and AKT activity was inhibited by the EGFR inhibitor, PD153035; ERK inhibitor, U0126; and PI3 kinase inhibitor, LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Homo sapiens	27-30
16211242-6	2005	Both PI3K/Akt and MEK/ERK inhibitors, LY294002 and PD98059, attenuated the extent of BITC-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	mitogen-activated protein kinase kinase 7	Homo sapiens	18-21
16211242-6	2005	Both PI3K/Akt and MEK/ERK inhibitors, LY294002 and PD98059, attenuated the extent of BITC-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	mitogen-activated protein kinase 1	Homo sapiens	22-25
16211242-7	2005	Pretreatment of cells with either the PD98059 or LY294002 inhibitor, caused a dose-dependent inhibition of histone H3 (p-H3) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	H3 clustered histone 14	Homo sapiens	115-117
16211242-7	2005	Pretreatment of cells with either the PD98059 or LY294002 inhibitor, caused a dose-dependent inhibition of histone H3 (p-H3) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	H3 clustered histone 14	Homo sapiens	119-123
16211242-8	2005	Despite the LY294002 inhibitor having no effect on the proportion of ITC-induced G2/M arrested cells, a significant decrease of p-H3/(G2/M) ratio in both PD98059- and LY294002-treated cells was observed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	H3 clustered histone 14	Homo sapiens	128-132
16211288-4	2005	We found that both PI 3-K inhibitors, wortmannin and LY294002, markedly suppressed phosphorylation of Akt and Bad in HL-60 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	102-105
16283513-6	2005	Pre-treatment of Cl 41 cells with PI-3K inhibitor, wortmannin or Ly294002, resulted in a striking inhibition of VEGF induction by nickel compounds, implicating the role of PI-3K in the induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	vascular endothelial growth factor A	Homo sapiens	112-116
16241951-4	2005	Wortmannin and LY29400, two PI3-K inhibitors, suppressed the potentiating effects of MMP-2 and preincubation with MMP-2 enhanced the thrombin-induced association of the p85alpha PI3-K subunit with the cytoskeleton and increased the phosphorylation of PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-22	matrix metallopeptidase 2	Homo sapiens	85-90
16241951-4	2005	Wortmannin and LY29400, two PI3-K inhibitors, suppressed the potentiating effects of MMP-2 and preincubation with MMP-2 enhanced the thrombin-induced association of the p85alpha PI3-K subunit with the cytoskeleton and increased the phosphorylation of PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-22	matrix metallopeptidase 2	Homo sapiens	114-119
16241951-4	2005	Wortmannin and LY29400, two PI3-K inhibitors, suppressed the potentiating effects of MMP-2 and preincubation with MMP-2 enhanced the thrombin-induced association of the p85alpha PI3-K subunit with the cytoskeleton and increased the phosphorylation of PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-22	coagulation factor II, thrombin	Homo sapiens	133-141
16241951-4	2005	Wortmannin and LY29400, two PI3-K inhibitors, suppressed the potentiating effects of MMP-2 and preincubation with MMP-2 enhanced the thrombin-induced association of the p85alpha PI3-K subunit with the cytoskeleton and increased the phosphorylation of PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-22	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	169-177
16264263-7	2005	In addition, a PI3-kinase inhibitor, LY294002, induced the downregulation of IGF-II expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	insulin like growth factor 2	Homo sapiens	77-83
16183388-8	2005	The activations of TK and PI3K pathways are essential events for FTL-induced chemotaxis, since inhibitors of these pathways, genistein and LY294002, inhibited neutrophil migration in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	TXK tyrosine kinase	Homo sapiens	19-21
16007144-7	2005	The role of PI3K and NF-kappaB activation in LMP1-mediated transformation was further analysed using the chemical inhibitors LY294002 and BAY 11-7085.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	PDZ and LIM domain 7	Homo sapiens	45-49
16055446-7	2005	Because the PI3K inhibitor LY294002 prevented the Mig- and NGF-induced survival effect, this effect is probably mediated by the PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	C-X-C motif chemokine ligand 9	Rattus norvegicus	50-53
16007163-4	2005	Blocking AKT with the PI3K/AKT inhibitor LY294002 or AKT SiRNA prevented NF-kappaB activation and inhibition of p53.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	9-12
16007163-4	2005	Blocking AKT with the PI3K/AKT inhibitor LY294002 or AKT SiRNA prevented NF-kappaB activation and inhibition of p53.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	27-30
16007163-4	2005	Blocking AKT with the PI3K/AKT inhibitor LY294002 or AKT SiRNA prevented NF-kappaB activation and inhibition of p53.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	27-30
16007163-4	2005	Blocking AKT with the PI3K/AKT inhibitor LY294002 or AKT SiRNA prevented NF-kappaB activation and inhibition of p53.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	tumor protein p53	Homo sapiens	112-115
16007163-5	2005	Treatment of C81 cells with LY294002 resulted in an increase in the p53-responsive gene MDM2, suggesting a role for AKT in the Tax-mediated regulation of p53 transcriptional activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	tumor protein p53	Homo sapiens	68-71
16007163-5	2005	Treatment of C81 cells with LY294002 resulted in an increase in the p53-responsive gene MDM2, suggesting a role for AKT in the Tax-mediated regulation of p53 transcriptional activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	MDM2 proto-oncogene	Homo sapiens	88-92
16007163-5	2005	Treatment of C81 cells with LY294002 resulted in an increase in the p53-responsive gene MDM2, suggesting a role for AKT in the Tax-mediated regulation of p53 transcriptional activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	116-119
16055446-7	2005	Because the PI3K inhibitor LY294002 prevented the Mig- and NGF-induced survival effect, this effect is probably mediated by the PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	nerve growth factor	Rattus norvegicus	59-62
16007163-5	2005	Treatment of C81 cells with LY294002 resulted in an increase in the p53-responsive gene MDM2, suggesting a role for AKT in the Tax-mediated regulation of p53 transcriptional activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	tumor protein p53	Homo sapiens	154-157
16209943-4	2005	Suppression of Akt activation by the PI3K-inhibitor PTEN or LY294002, Akt expression by RNA-interference, or Akt function by dominant-negative Akt caused apoptosis in cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Homo sapiens	15-18
16007163-6	2005	Further, we show that LY294002 treatment of C81 cells abrogates in vitro IKKbeta phosphorylation of p65 and causes a reduction of p65 Ser-536 phosphorylation in vivo, steps critical to p53 inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	73-80
16007163-6	2005	Further, we show that LY294002 treatment of C81 cells abrogates in vitro IKKbeta phosphorylation of p65 and causes a reduction of p65 Ser-536 phosphorylation in vivo, steps critical to p53 inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	RELA proto-oncogene, NF-kB subunit	Homo sapiens	100-103
16007163-6	2005	Further, we show that LY294002 treatment of C81 cells abrogates in vitro IKKbeta phosphorylation of p65 and causes a reduction of p65 Ser-536 phosphorylation in vivo, steps critical to p53 inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	RELA proto-oncogene, NF-kB subunit	Homo sapiens	130-133
16007163-6	2005	Further, we show that LY294002 treatment of C81 cells abrogates in vitro IKKbeta phosphorylation of p65 and causes a reduction of p65 Ser-536 phosphorylation in vivo, steps critical to p53 inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	tumor protein p53	Homo sapiens	185-188
16162974-6	2005	Finally, the analysis of the molecular markers that might be implicated in the synergism between LY294002 and gemcitabine suggests that PI3K inhibition might aid chemotherapeutic treatment, leading to changes in the balance between anti- and pro-apoptotic molecules of the Bcl-2 family, Bcl-XL and Bax.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	BCL2 apoptosis regulator	Homo sapiens	273-278
16174443-4	2005	RESULTS: The PI3K inhibitors wortmannin and Ly294002, but not rapamycin, completely inhibited the phosphorylation of Akt and PRAS40.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	117-120
16174443-4	2005	RESULTS: The PI3K inhibitors wortmannin and Ly294002, but not rapamycin, completely inhibited the phosphorylation of Akt and PRAS40.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT1 substrate 1	Homo sapiens	125-131
16162974-6	2005	Finally, the analysis of the molecular markers that might be implicated in the synergism between LY294002 and gemcitabine suggests that PI3K inhibition might aid chemotherapeutic treatment, leading to changes in the balance between anti- and pro-apoptotic molecules of the Bcl-2 family, Bcl-XL and Bax.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	BCL2 like 1	Homo sapiens	287-293
16162974-6	2005	Finally, the analysis of the molecular markers that might be implicated in the synergism between LY294002 and gemcitabine suggests that PI3K inhibition might aid chemotherapeutic treatment, leading to changes in the balance between anti- and pro-apoptotic molecules of the Bcl-2 family, Bcl-XL and Bax.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	BCL2 associated X, apoptosis regulator	Homo sapiens	298-301
16086034-4	2005	In agreement with this finding, the proliferation of hypoxia-treated VSMCs in response to PlGF was significantly impaired by the p38 and the phosphatidylinositol 3-kinase inhibitors SB202190 and LY294002, respectively, and was almost completely prevented by AG490, a janus tyrosine kinase (JAK)/signal transducer and activator of transcription (STAT) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	placental growth factor	Rattus norvegicus	90-94
16195373-7	2005	PI3 kinase inhibition (LY294002) attenuated S1P-induced Tiam1 association with S1P1, Tiam1/Rac1 activation, alpha-actinin-1/4 recruitment, and EC barrier enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	TIAM Rac1 associated GEF 1	Homo sapiens	56-61
16054131-7	2005	These effects induced by FBS or EGF were attenuated in the presence of protein kinase C (PKC) inhibitors calphostin C and bisindolylmaleimide I, but not another PKC inhibitor Go6976, PD98059 (MAPK inhibitor), LY294002 (PI3 kinase inhibitor) or KT5720 (protein kinase A inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	209-217	epidermal growth factor	Homo sapiens	32-35
16195373-7	2005	PI3 kinase inhibition (LY294002) attenuated S1P-induced Tiam1 association with S1P1, Tiam1/Rac1 activation, alpha-actinin-1/4 recruitment, and EC barrier enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	sphingosine-1-phosphate receptor 1	Homo sapiens	79-83
16195373-7	2005	PI3 kinase inhibition (LY294002) attenuated S1P-induced Tiam1 association with S1P1, Tiam1/Rac1 activation, alpha-actinin-1/4 recruitment, and EC barrier enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	Rac family small GTPase 1	Homo sapiens	91-95
16195373-7	2005	PI3 kinase inhibition (LY294002) attenuated S1P-induced Tiam1 association with S1P1, Tiam1/Rac1 activation, alpha-actinin-1/4 recruitment, and EC barrier enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	actinin alpha 1	Homo sapiens	108-123
16195373-7	2005	PI3 kinase inhibition (LY294002) attenuated S1P-induced Tiam1 association with S1P1, Tiam1/Rac1 activation, alpha-actinin-1/4 recruitment, and EC barrier enhancement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	TIAM Rac1 associated GEF 1	Homo sapiens	85-90
16081599-6	2005	gp120-elicited TNF-alpha production was also blocked by phosphatidylinositol-3 kinase (PI-3K) inhibitors (wortmannin, LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	0-5
15927518-8	2005	The PI3K inhibitor LY294002 and the mTOR inhibitor rapamycin reversed the anabolic effect of IGF-I in dexamethasone-treated myotubes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	insulin like growth factor 1	Homo sapiens	93-98
16081599-6	2005	gp120-elicited TNF-alpha production was also blocked by phosphatidylinositol-3 kinase (PI-3K) inhibitors (wortmannin, LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	tumor necrosis factor	Homo sapiens	15-24
16081599-6	2005	gp120-elicited TNF-alpha production was also blocked by phosphatidylinositol-3 kinase (PI-3K) inhibitors (wortmannin, LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	56-85
16164642-13	2005	ERK phosphorylation was abolished by LY294002, suggesting ERK was downstream of PI3K in VEGF-treated GENC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	mitogen-activated protein kinase 1	Homo sapiens	0-3
16009452-6	2005	Gefitinib also inhibited the phosphorylation of MAPK and Akt, and the selective inhibitors PD98059 and LY294002 also suppressed MUC5AC protein synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	128-134
16087246-6	2005	The CCL6-mediated cell migration was blocked by treating the cells with LY294002, a PI3-kinase inhibitor and Western blot analysis showed that the phosphorylation of Akt could be induced by treating microglia with a recombinant CCL6, suggesting that CCL6 functions by activating the PI3-kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	C-C motif chemokine ligand 6	Rattus norvegicus	4-8
16087246-6	2005	The CCL6-mediated cell migration was blocked by treating the cells with LY294002, a PI3-kinase inhibitor and Western blot analysis showed that the phosphorylation of Akt could be induced by treating microglia with a recombinant CCL6, suggesting that CCL6 functions by activating the PI3-kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Rattus norvegicus	166-169
16087246-6	2005	The CCL6-mediated cell migration was blocked by treating the cells with LY294002, a PI3-kinase inhibitor and Western blot analysis showed that the phosphorylation of Akt could be induced by treating microglia with a recombinant CCL6, suggesting that CCL6 functions by activating the PI3-kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	C-C motif chemokine ligand 6	Rattus norvegicus	228-232
16087246-6	2005	The CCL6-mediated cell migration was blocked by treating the cells with LY294002, a PI3-kinase inhibitor and Western blot analysis showed that the phosphorylation of Akt could be induced by treating microglia with a recombinant CCL6, suggesting that CCL6 functions by activating the PI3-kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	C-C motif chemokine ligand 6	Rattus norvegicus	228-232
16087246-6	2005	The CCL6-mediated cell migration was blocked by treating the cells with LY294002, a PI3-kinase inhibitor and Western blot analysis showed that the phosphorylation of Akt could be induced by treating microglia with a recombinant CCL6, suggesting that CCL6 functions by activating the PI3-kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Rattus norvegicus	294-297
15980059-3	2005	The AA-mediated activation of p70S6K, but not PKC, was abolished by inhibition of PI 3-K with LY294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] or wortmannin, in agreement with p70S6K being downstream of phosphatidylinositol 3-kinase (PI 3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	ribosomal protein S6 kinase B1	Rattus norvegicus	30-36
15980059-3	2005	The AA-mediated activation of p70S6K, but not PKC, was abolished by inhibition of PI 3-K with LY294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] or wortmannin, in agreement with p70S6K being downstream of phosphatidylinositol 3-kinase (PI 3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	ribosomal protein S6 kinase B1	Rattus norvegicus	187-193
15980059-3	2005	The AA-mediated activation of p70S6K, but not PKC, was abolished by inhibition of PI 3-K with LY294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] or wortmannin, in agreement with p70S6K being downstream of phosphatidylinositol 3-kinase (PI 3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	214-243
15980059-3	2005	The AA-mediated activation of p70S6K, but not PKC, was abolished by inhibition of PI 3-K with LY294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] or wortmannin, in agreement with p70S6K being downstream of phosphatidylinositol 3-kinase (PI 3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-152	ribosomal protein S6 kinase B1	Rattus norvegicus	30-36
16164642-11	2005	VEGF-induced eNOS phosphorylation was abolished by SU1498, a VEGF-R2 inhibitor, LY294002, a PI3K inhibitor, and infection of cells with an adenovirus carrying a dominant negative-mutant of Akt, demonstrating the requirement of the VEGF-R2/IRS-1/PI3K/Akt axis for activation of eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	vascular endothelial growth factor A	Homo sapiens	0-4
16164642-13	2005	ERK phosphorylation was abolished by LY294002, suggesting ERK was downstream of PI3K in VEGF-treated GENC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	mitogen-activated protein kinase 1	Homo sapiens	58-61
16164642-13	2005	ERK phosphorylation was abolished by LY294002, suggesting ERK was downstream of PI3K in VEGF-treated GENC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	vascular endothelial growth factor A	Homo sapiens	88-92
16044407-6	2005	The induction of COX-2 elicited by TPA correlated with increased activation of Akt kinase and cell treatment with the PI3 kinase inhibitor, LY294002, blocked TPA induction of COX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22
16086373-11	2005	In addition, inhibition of PI3K/Akt with LY294002 reversed many of the cell cycle related changes observed in untreated transgenic animals.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	thymoma viral proto-oncogene 1	Mus musculus	32-35
16044407-6	2005	The induction of COX-2 elicited by TPA correlated with increased activation of Akt kinase and cell treatment with the PI3 kinase inhibitor, LY294002, blocked TPA induction of COX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	AKT serine/threonine kinase 1	Homo sapiens	79-82
16044407-6	2005	The induction of COX-2 elicited by TPA correlated with increased activation of Akt kinase and cell treatment with the PI3 kinase inhibitor, LY294002, blocked TPA induction of COX-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	prostaglandin-endoperoxide synthase 2	Homo sapiens	175-180
16172287-9	2005	EXP3179 significantly inhibited tumor necrosis factor alpha-induced apoptosis by approximately 60% (from 30.1+/-5.8% to 12.2+/-2.0% TUNEL-positive cells), which was abolished by pretreatment with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	tumor necrosis factor	Rattus norvegicus	32-59
16086373-10	2005	In further studies, the PI3K inhibitor, LY294002, significantly blocked IGF-1-mediated epidermal proliferation and skin tumor promotion in DMBA-initiated BK5.IGF-1 mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	insulin-like growth factor 1	Mus musculus	72-77
16086373-10	2005	In further studies, the PI3K inhibitor, LY294002, significantly blocked IGF-1-mediated epidermal proliferation and skin tumor promotion in DMBA-initiated BK5.IGF-1 mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	insulin-like growth factor 1	Mus musculus	158-163
16142341-6	2005	Inhibition of PI3K-Akt signaling in LM8 by a PI3K inhibitor, LY294002, or by a dominant negative form of Akt, resulted in suppression of MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Homo sapiens	19-22
16315601-5	2005	Results show that both exogenous and endogenous EETs could remarkably enhance eNOS expression and its phosphorylation at Ser1179 and Thr497 residues; PI3K inhibitor LY294002 could inhibit EETs-induced increase in eNOS-Ser(P)1179 but had no effect on the change of eNOS-Thr(P)497, while Akt inhibitor could attenuate the increase in phosphor-eNOS at both residues; both of the two inhibitors could block EETs-enhanced eNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	nitric oxide synthase 3	Bos taurus	78-82
16315601-5	2005	Results show that both exogenous and endogenous EETs could remarkably enhance eNOS expression and its phosphorylation at Ser1179 and Thr497 residues; PI3K inhibitor LY294002 could inhibit EETs-induced increase in eNOS-Ser(P)1179 but had no effect on the change of eNOS-Thr(P)497, while Akt inhibitor could attenuate the increase in phosphor-eNOS at both residues; both of the two inhibitors could block EETs-enhanced eNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	nitric oxide synthase 3	Bos taurus	213-217
16315601-5	2005	Results show that both exogenous and endogenous EETs could remarkably enhance eNOS expression and its phosphorylation at Ser1179 and Thr497 residues; PI3K inhibitor LY294002 could inhibit EETs-induced increase in eNOS-Ser(P)1179 but had no effect on the change of eNOS-Thr(P)497, while Akt inhibitor could attenuate the increase in phosphor-eNOS at both residues; both of the two inhibitors could block EETs-enhanced eNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	nitric oxide synthase 3	Bos taurus	213-217
16315601-5	2005	Results show that both exogenous and endogenous EETs could remarkably enhance eNOS expression and its phosphorylation at Ser1179 and Thr497 residues; PI3K inhibitor LY294002 could inhibit EETs-induced increase in eNOS-Ser(P)1179 but had no effect on the change of eNOS-Thr(P)497, while Akt inhibitor could attenuate the increase in phosphor-eNOS at both residues; both of the two inhibitors could block EETs-enhanced eNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	AKT serine/threonine kinase 1	Bos taurus	286-289
16315601-5	2005	Results show that both exogenous and endogenous EETs could remarkably enhance eNOS expression and its phosphorylation at Ser1179 and Thr497 residues; PI3K inhibitor LY294002 could inhibit EETs-induced increase in eNOS-Ser(P)1179 but had no effect on the change of eNOS-Thr(P)497, while Akt inhibitor could attenuate the increase in phosphor-eNOS at both residues; both of the two inhibitors could block EETs-enhanced eNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	nitric oxide synthase 3	Bos taurus	213-217
16315601-5	2005	Results show that both exogenous and endogenous EETs could remarkably enhance eNOS expression and its phosphorylation at Ser1179 and Thr497 residues; PI3K inhibitor LY294002 could inhibit EETs-induced increase in eNOS-Ser(P)1179 but had no effect on the change of eNOS-Thr(P)497, while Akt inhibitor could attenuate the increase in phosphor-eNOS at both residues; both of the two inhibitors could block EETs-enhanced eNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	nitric oxide synthase 3	Bos taurus	213-217
16105742-6	2005	MCP-1-induced phosphorylation of p42/44(ERK1/2) MAPKs was partially blocked by inhibitor of PI3K LY294002, while phosphorylation of p38 MAPK was diminished to a greater extent in presence of Src-kinase inhibitor PP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	chemokine (C-C motif) ligand 2	Mus musculus	0-5
16105742-6	2005	MCP-1-induced phosphorylation of p42/44(ERK1/2) MAPKs was partially blocked by inhibitor of PI3K LY294002, while phosphorylation of p38 MAPK was diminished to a greater extent in presence of Src-kinase inhibitor PP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	cyclin-dependent kinase 20	Mus musculus	33-36
16105742-6	2005	MCP-1-induced phosphorylation of p42/44(ERK1/2) MAPKs was partially blocked by inhibitor of PI3K LY294002, while phosphorylation of p38 MAPK was diminished to a greater extent in presence of Src-kinase inhibitor PP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	mitogen-activated protein kinase 3	Mus musculus	40-46
16036916-8	2005	Transformation induced by NBS1 overexpression can be inhibited by a PI3-kinase inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	nibrin	Homo sapiens	26-30
16166632-7	2005	Overexpression of eIF4E rendered polysome recruitment of mRNAs with structured 5" untranslated regions largely independent of growth factor and resistant to the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	eukaryotic translation initiation factor 4E	Homo sapiens	18-23
16061480-5	2005	Under normal growth conditions, blocking PI3K/Akt signals by LY294002 causes LNCaP cell arrest in G1 phase rather than apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Homo sapiens	46-49
16061480-6	2005	However, further blocking of AR functions by AR small interfering RNA leads to dramatic LNCaP cell death, suggesting that AR may play important protective roles when the PI3K/Akt signal pathway is blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	androgen receptor	Homo sapiens	29-31
16061480-6	2005	However, further blocking of AR functions by AR small interfering RNA leads to dramatic LNCaP cell death, suggesting that AR may play important protective roles when the PI3K/Akt signal pathway is blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	androgen receptor	Homo sapiens	45-47
16061480-6	2005	However, further blocking of AR functions by AR small interfering RNA leads to dramatic LNCaP cell death, suggesting that AR may play important protective roles when the PI3K/Akt signal pathway is blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	androgen receptor	Homo sapiens	45-47
16061480-6	2005	However, further blocking of AR functions by AR small interfering RNA leads to dramatic LNCaP cell death, suggesting that AR may play important protective roles when the PI3K/Akt signal pathway is blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	AKT serine/threonine kinase 1	Homo sapiens	175-178
16177181-6	2005	In addition, we show that potential anti-cancer drugs (LY-294002 and vanillin) that inhibit the family of phosphatidylinositol 3 kinases that include the NHEJ protein, DNA-PKCS act in synergy with TSA to reduce the viability of HeLa cells in tissue culture presenting the possibility of using the two drugs in combination to treat cancer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-64	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	168-176
16166321-5	2005	Inhibitors of the PI3K/Akt/mTOR pathway (LY294002, rapamycin) but not the MEK/ERK pathway (U0126) abrogated laminin-mediated survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	23-26
16166321-5	2005	Inhibitors of the PI3K/Akt/mTOR pathway (LY294002, rapamycin) but not the MEK/ERK pathway (U0126) abrogated laminin-mediated survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	mechanistic target of rapamycin kinase	Homo sapiens	27-31
15994321-9	2005	The synergistic effect of LPL on IFN-gamma-induced Stat1 activation was mediated by enhanced activation of the tyrosine kinase JAK2 and was abrogated by LY294002, a specific inhibitor of the phosphatidylinositol 3"-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	lipoprotein lipase	Homo sapiens	26-29
16081165-8	2005	These analyses also provide support for the involvement of the PI-3K pathway; ipsapirone stimulated the phosphorylation of Akt in control and ethanol-treated neurons, and these effects were antagonized by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	AKT serine/threonine kinase 1	Homo sapiens	123-126
16027165-6	2005	In addition, VCP expression and association with Akt was enhanced during SH, and this association was decreased upon phosphoinositide 3-kinase/Akt pathway blockade with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	valosin-containing protein	Rattus norvegicus	13-16
16027165-6	2005	In addition, VCP expression and association with Akt was enhanced during SH, and this association was decreased upon phosphoinositide 3-kinase/Akt pathway blockade with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Rattus norvegicus	143-146
15994321-9	2005	The synergistic effect of LPL on IFN-gamma-induced Stat1 activation was mediated by enhanced activation of the tyrosine kinase JAK2 and was abrogated by LY294002, a specific inhibitor of the phosphatidylinositol 3"-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	interferon gamma	Homo sapiens	33-42
15994321-9	2005	The synergistic effect of LPL on IFN-gamma-induced Stat1 activation was mediated by enhanced activation of the tyrosine kinase JAK2 and was abrogated by LY294002, a specific inhibitor of the phosphatidylinositol 3"-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	signal transducer and activator of transcription 1	Homo sapiens	51-56
16076309-8	2005	RESULTS: Two PI3K inhibitors, wortmannin and LY294002, caused concentration-dependent inhibition of PAF-induced eosinophil chemotaxis (IC(50) = 0.54 nM and 0.15 microM, respectively) but exhibited at least 100-fold lower potency against eotaxin-induced responses (IC(50) = 48 nM and &gt;100 microM, respectively), indicating that these responses were not dependent upon PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	C-C motif chemokine ligand 11	Homo sapiens	237-244
15944807-8	2005	U0126, wortmannin and LY294002 all abrogated EPO-mediated protection (% I/R 49.2% +/- 5.6, 46.1% +/- 5.5 and 49.9% +/- 6.1 respectively, p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	erythropoietin	Rattus norvegicus	45-48
16115127-7	2005	LY294002 treatment of acute promyelocytic primary blasts with elevated Akt phosphorylation levels resulted in an increased sensitivity to As2O3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	71-74
16266864-7	2005	Experiments using inhibitors of metabolic pathways (U0126, LY294002 and SN50) revealed that the secretion of MMP-9 was mediated through PI3/MEK1 kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	matrix metallopeptidase 9	Homo sapiens	109-114
15947004-6	2005	The EGF-induced redistribution of GFP-ERalpha was blocked by pretreatment with a MAPK cascade inhibitor, PD98059, whereas the IGF-I-induced redistribution of GFP-ERalpha was blocked by pretreatment with a phosphatidylinositol 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-254	epidermal growth factor	Homo sapiens	4-7
15947004-6	2005	The EGF-induced redistribution of GFP-ERalpha was blocked by pretreatment with a MAPK cascade inhibitor, PD98059, whereas the IGF-I-induced redistribution of GFP-ERalpha was blocked by pretreatment with a phosphatidylinositol 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-254	insulin like growth factor 1	Homo sapiens	126-131
16140916-3	2005	Overexpression of galectin-3 in J82 human bladder carcinoma cells rendered them resistant to TRAIL-induced apoptosis, whereas phosphatidylinositol 3-kinase (PI3K) inhibitors (wortmannin and LY-294002) blocked the galectin-3 protecting effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-199	galectin 3	Homo sapiens	18-28
15855272-7	2005	Bim phosphorylation was inhibited by PD98059 and LY294002 treatment, suggesting the involvement of mitogen-activated protein kinase kinase/mitogen-activated protein kinase (MEK/MAPK) and phosphatidylinositol 3 (PI3)-kinase pathways in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	BCL2 like 11	Homo sapiens	0-3
16106368-4	2005	The MAPK kinase (MEK) 1 inhibitor PD098059, the protein kinase C (PKC) inhibitor Ro31,8220, and the phosphatidylinositol-3 kinase (PI3-K) inhibitor LY294002 all partially reversed LPS-mediated retardation of neutrophil apoptosis, but the p38 MAPK inhibitor SB203850 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	100-129
16114097-3	2005	The inhibitors of PI3K activity, LY294002 and Wortmannin, also abrogate cyclin D2 induction by BCR cross-linking, confirming that the class IA PI3K is necessary for cyclin D2 induction in response to BCR stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	cyclin D2	Mus musculus	72-81
16114097-3	2005	The inhibitors of PI3K activity, LY294002 and Wortmannin, also abrogate cyclin D2 induction by BCR cross-linking, confirming that the class IA PI3K is necessary for cyclin D2 induction in response to BCR stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	cyclin D2	Mus musculus	165-174
16128807-3	2005	In three different hemopoietic cell lines stimulated with cytokines, and in HEK293 cells, stimulated with serum, either wortmannin or LY294002, but never both, could partially block phosphorylation of Erks.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	mitogen-activated protein kinase 3	Homo sapiens	201-205
15815584-5	2005	Coincubation of neurospheres with Sildenafil and LY 294002, a pharmacological inhibitor of PI3-K/Akt, abolished Sildenafil-induced phosphorylated Akt and GSK-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-58	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
15815584-5	2005	Coincubation of neurospheres with Sildenafil and LY 294002, a pharmacological inhibitor of PI3-K/Akt, abolished Sildenafil-induced phosphorylated Akt and GSK-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-58	AKT serine/threonine kinase 1	Rattus norvegicus	146-149
16093915-9	2005	Interestingly, reverse transcriptase-PCR analysis demonstrated that 17beta-estradiol dose-dependently increased the catalytic subunit, telomerase reverse transcriptase (TERT) - an effect that was significantly inhibited by pharmacological phosphatidylinositol 3-kinase (PI3-K) blockers (either wortmannin or LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	308-316	telomerase reverse transcriptase	Homo sapiens	169-173
16093915-9	2005	Interestingly, reverse transcriptase-PCR analysis demonstrated that 17beta-estradiol dose-dependently increased the catalytic subunit, telomerase reverse transcriptase (TERT) - an effect that was significantly inhibited by pharmacological phosphatidylinositol 3-kinase (PI3-K) blockers (either wortmannin or LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	308-316	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	239-268
16140203-8	2005	The ability of IGF-I to activate the pro-survival PKB pathway in ATCs was inhibited by LY294002, indicating the importance of PI3K in the response of ATCs to IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	insulin like growth factor 1	Homo sapiens	15-20
16140203-8	2005	The ability of IGF-I to activate the pro-survival PKB pathway in ATCs was inhibited by LY294002, indicating the importance of PI3K in the response of ATCs to IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	50-53
16140203-8	2005	The ability of IGF-I to activate the pro-survival PKB pathway in ATCs was inhibited by LY294002, indicating the importance of PI3K in the response of ATCs to IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	insulin like growth factor 1	Homo sapiens	158-163
16007110-9	2005	Re-expression of CL 2 in response to IL-13 was inhibited by phophatidylinositol 3 kinase inhibitor, LY294002, which also restored the ion permeability to previous levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	endogenous retrovirus group W member 5	Homo sapiens	17-21
16007110-9	2005	Re-expression of CL 2 in response to IL-13 was inhibited by phophatidylinositol 3 kinase inhibitor, LY294002, which also restored the ion permeability to previous levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	interleukin 13	Homo sapiens	37-42
16135959-10	2005	The enhanced MMP-9 levels induced by peptidoglycan was attenuated by inhibitors of p38 mitogen-activated protein kinases (MAPK), (SB202190, 25 microM) and ERK1/2 (PD98059, 25 microM) and inhibitors of Src Tyrosine kinase (PP2, 5 microM) and PI3-K (LY294002, 25 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	248-256	matrix metallopeptidase 9	Homo sapiens	13-18
16135959-10	2005	The enhanced MMP-9 levels induced by peptidoglycan was attenuated by inhibitors of p38 mitogen-activated protein kinases (MAPK), (SB202190, 25 microM) and ERK1/2 (PD98059, 25 microM) and inhibitors of Src Tyrosine kinase (PP2, 5 microM) and PI3-K (LY294002, 25 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	248-256	mitogen-activated protein kinase 3	Homo sapiens	122-126
16135669-6	2005	Interestingly, the IGF-1-elicited protective effect against HG was nullified by either LY294002 or rapamycin, but not by cyclosporine A or FK506.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	insulin like growth factor 1	Homo sapiens	19-24
15923340-4	2005	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) blocks mTOR kinase activity, but it also inhibits phosphatidylinositol 3-kinase (PI3K), an enzyme that regulates cellular functions other than proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-48	mechanistic target of rapamycin kinase	Homo sapiens	67-71
15923340-4	2005	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) blocks mTOR kinase activity, but it also inhibits phosphatidylinositol 3-kinase (PI3K), an enzyme that regulates cellular functions other than proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-48	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	110-139
15923340-4	2005	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) blocks mTOR kinase activity, but it also inhibits phosphatidylinositol 3-kinase (PI3K), an enzyme that regulates cellular functions other than proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	mechanistic target of rapamycin kinase	Homo sapiens	67-71
15923340-4	2005	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) blocks mTOR kinase activity, but it also inhibits phosphatidylinositol 3-kinase (PI3K), an enzyme that regulates cellular functions other than proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	110-139
15993382-7	2005	PI3 kinase inhibitor, wortmannin or LY294002 eliminated erythropoietin"s inhibitory effect on caspase-3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	erythropoietin	Homo sapiens	56-70
15993382-7	2005	PI3 kinase inhibitor, wortmannin or LY294002 eliminated erythropoietin"s inhibitory effect on caspase-3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	caspase 3	Homo sapiens	94-103
15855272-7	2005	Bim phosphorylation was inhibited by PD98059 and LY294002 treatment, suggesting the involvement of mitogen-activated protein kinase kinase/mitogen-activated protein kinase (MEK/MAPK) and phosphatidylinositol 3 (PI3)-kinase pathways in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mitogen-activated protein kinase kinase 7	Homo sapiens	173-176
16103079-5	2005	Wortmannin and LY294002, two specific inhibitors of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and S6K1 phosphorylation, whereas rapamycin, a specific inhibitor of Akt downstream effector, mammalian target of rapamycin (mTOR), suppressed only S6K1 phosphorylation induced by 15(S)-HETE suggesting that this eicosanoid activates the PI3K-Akt-mTOR-S6K1 signaling in HDMVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	103-106
16103051-9	2005	The rapamycin-induced phosphorylation of Akt and eIF4E was suppressed by the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002, suggesting the requirement of PI3K in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	AKT serine/threonine kinase 1	Homo sapiens	41-44
15952178-7	2005	The phosphatidylinositol 3"-kinase (PI3K) inhibitors LY294002 and wortmannin, and the MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitors U0126 and PD98059, reduced HB-EGF-induced BrdU incorporation into cultures, and HB-EGF enhanced phosphorylation of Akt and ERK, implying a role for PI3K/Akt and MEK/ERK signaling in HB-EGF-stimulated cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-34
16103051-9	2005	The rapamycin-induced phosphorylation of Akt and eIF4E was suppressed by the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002, suggesting the requirement of PI3K in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	eukaryotic translation initiation factor 4E	Homo sapiens	49-54
16103051-9	2005	The rapamycin-induced phosphorylation of Akt and eIF4E was suppressed by the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002, suggesting the requirement of PI3K in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	77-106
15946966-7	2005	PE (10 microm) increased phosphorylation of Akt, which was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	44-47
16103079-5	2005	Wortmannin and LY294002, two specific inhibitors of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and S6K1 phosphorylation, whereas rapamycin, a specific inhibitor of Akt downstream effector, mammalian target of rapamycin (mTOR), suppressed only S6K1 phosphorylation induced by 15(S)-HETE suggesting that this eicosanoid activates the PI3K-Akt-mTOR-S6K1 signaling in HDMVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	ribosomal protein S6 kinase B1	Homo sapiens	111-115
16103079-5	2005	Wortmannin and LY294002, two specific inhibitors of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and S6K1 phosphorylation, whereas rapamycin, a specific inhibitor of Akt downstream effector, mammalian target of rapamycin (mTOR), suppressed only S6K1 phosphorylation induced by 15(S)-HETE suggesting that this eicosanoid activates the PI3K-Akt-mTOR-S6K1 signaling in HDMVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	176-179
16103079-5	2005	Wortmannin and LY294002, two specific inhibitors of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and S6K1 phosphorylation, whereas rapamycin, a specific inhibitor of Akt downstream effector, mammalian target of rapamycin (mTOR), suppressed only S6K1 phosphorylation induced by 15(S)-HETE suggesting that this eicosanoid activates the PI3K-Akt-mTOR-S6K1 signaling in HDMVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mechanistic target of rapamycin kinase	Homo sapiens	201-230
16103079-5	2005	Wortmannin and LY294002, two specific inhibitors of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and S6K1 phosphorylation, whereas rapamycin, a specific inhibitor of Akt downstream effector, mammalian target of rapamycin (mTOR), suppressed only S6K1 phosphorylation induced by 15(S)-HETE suggesting that this eicosanoid activates the PI3K-Akt-mTOR-S6K1 signaling in HDMVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mechanistic target of rapamycin kinase	Homo sapiens	232-236
16103079-5	2005	Wortmannin and LY294002, two specific inhibitors of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and S6K1 phosphorylation, whereas rapamycin, a specific inhibitor of Akt downstream effector, mammalian target of rapamycin (mTOR), suppressed only S6K1 phosphorylation induced by 15(S)-HETE suggesting that this eicosanoid activates the PI3K-Akt-mTOR-S6K1 signaling in HDMVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	ribosomal protein S6 kinase B1	Homo sapiens	255-259
16103079-5	2005	Wortmannin and LY294002, two specific inhibitors of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and S6K1 phosphorylation, whereas rapamycin, a specific inhibitor of Akt downstream effector, mammalian target of rapamycin (mTOR), suppressed only S6K1 phosphorylation induced by 15(S)-HETE suggesting that this eicosanoid activates the PI3K-Akt-mTOR-S6K1 signaling in HDMVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	176-179
16103079-5	2005	Wortmannin and LY294002, two specific inhibitors of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and S6K1 phosphorylation, whereas rapamycin, a specific inhibitor of Akt downstream effector, mammalian target of rapamycin (mTOR), suppressed only S6K1 phosphorylation induced by 15(S)-HETE suggesting that this eicosanoid activates the PI3K-Akt-mTOR-S6K1 signaling in HDMVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mechanistic target of rapamycin kinase	Homo sapiens	353-357
16103079-5	2005	Wortmannin and LY294002, two specific inhibitors of phosphatidylinositol 3-kinase (PI3K), blocked both Akt and S6K1 phosphorylation, whereas rapamycin, a specific inhibitor of Akt downstream effector, mammalian target of rapamycin (mTOR), suppressed only S6K1 phosphorylation induced by 15(S)-HETE suggesting that this eicosanoid activates the PI3K-Akt-mTOR-S6K1 signaling in HDMVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	ribosomal protein S6 kinase B1	Homo sapiens	255-259
16018989-9	2005	Our research indicated that LY294002, a PI3K inhibitor, significantly suppressed Akt1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	81-85
15871910-5	2005	The SPD-induced neuroprotection and activation of Akt were blocked by LY294002, a PI3-K inhibitor, suggesting that the anti-apoptotic action of SPD is mediated via the PI3-K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Rattus norvegicus	50-53
16046480-5	2005	Inhibition of PI3K with Wortmannin or LY294002 blocked IGF-1-stimulated plasmalemmal expansion at the growth cones of cultured neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	insulin like growth factor 1	Homo sapiens	55-60
15955810-4	2005	We observed the following: (a) Wortmannin and LY294002 at concentrations that inhibit class IA PI 3-kinase reduced but did not abate the C terminus gain, yet the myc epitope was unavailable for detection unless lawns or cells were permeabilized, suggesting the presence of GLUT4myc in docked, unfused vesicles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	solute carrier family 2 member 4	Homo sapiens	273-278
15871910-5	2005	The SPD-induced neuroprotection and activation of Akt were blocked by LY294002, a PI3-K inhibitor, suggesting that the anti-apoptotic action of SPD is mediated via the PI3-K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Rattus norvegicus	174-177
16018989-10	2005	Furthermore, LY294002 significantly strengthened both peaks of JNK1/2 activation, c-Jun activation, Bcl-2 phosphorylation, and the activation of caspase-3 during reperfusion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	BCL2, apoptosis regulator	Rattus norvegicus	100-105
16018989-10	2005	Furthermore, LY294002 significantly strengthened both peaks of JNK1/2 activation, c-Jun activation, Bcl-2 phosphorylation, and the activation of caspase-3 during reperfusion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	caspase 3	Rattus norvegicus	145-154
16133873-4	2005	PI3-K inhibitor, LY294002, reduced IGF-I-stimulated phosphorylation of FKHR, FKHRL1, and Akt, but did not affect Erk phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	insulin like growth factor 1	Homo sapiens	35-40
15801908-4	2005	The PI3K inhibitors LY294002 and wortmannin blocked IGF-I-stimulated Akt phosphorylation without blocking ERK phosphorylation and this was associated with complete inhibition of proteoglycan synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	insulin like growth factor 1	Homo sapiens	52-57
16133867-4	2005	Pretreatment of polyamine-depleted cells with LY294002 increased caspase-9 and caspase-3 activation and decreased basal levels of GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	caspase 9	Rattus norvegicus	65-74
16133867-4	2005	Pretreatment of polyamine-depleted cells with LY294002 increased caspase-9 and caspase-3 activation and decreased basal levels of GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	caspase 3	Rattus norvegicus	79-88
16133867-4	2005	Pretreatment of polyamine-depleted cells with LY294002 increased caspase-9 and caspase-3 activation and decreased basal levels of GSK-3beta phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	glycogen synthase kinase 3 beta	Rattus norvegicus	130-139
16133873-4	2005	PI3-K inhibitor, LY294002, reduced IGF-I-stimulated phosphorylation of FKHR, FKHRL1, and Akt, but did not affect Erk phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	forkhead box O1	Homo sapiens	71-75
16133873-4	2005	PI3-K inhibitor, LY294002, reduced IGF-I-stimulated phosphorylation of FKHR, FKHRL1, and Akt, but did not affect Erk phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	forkhead box O3	Homo sapiens	77-83
16133873-4	2005	PI3-K inhibitor, LY294002, reduced IGF-I-stimulated phosphorylation of FKHR, FKHRL1, and Akt, but did not affect Erk phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	AKT serine/threonine kinase 1	Homo sapiens	89-92
16061664-9	2005	p70 S6 kinase (p70 S6K) was activated by Ang1-treatment, although this activation was blocked by a PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	0-13
15894170-6	2005	Both NO donor and LPS/IFN-gamma markedly activated the PI3K activity and the phosphorylation of Akt and nuclear factor (NF)-kappaB DNA binding activity in mesangial cells, which could be inhibited by LY294002 and transfection of dominant-negative vectors of PI3K/p85 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	interferon gamma	Homo sapiens	22-31
15894170-6	2005	Both NO donor and LPS/IFN-gamma markedly activated the PI3K activity and the phosphorylation of Akt and nuclear factor (NF)-kappaB DNA binding activity in mesangial cells, which could be inhibited by LY294002 and transfection of dominant-negative vectors of PI3K/p85 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	AKT serine/threonine kinase 1	Homo sapiens	96-99
15894170-6	2005	Both NO donor and LPS/IFN-gamma markedly activated the PI3K activity and the phosphorylation of Akt and nuclear factor (NF)-kappaB DNA binding activity in mesangial cells, which could be inhibited by LY294002 and transfection of dominant-negative vectors of PI3K/p85 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	nuclear factor kappa B subunit 1	Homo sapiens	104-130
15894170-6	2005	Both NO donor and LPS/IFN-gamma markedly activated the PI3K activity and the phosphorylation of Akt and nuclear factor (NF)-kappaB DNA binding activity in mesangial cells, which could be inhibited by LY294002 and transfection of dominant-negative vectors of PI3K/p85 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	263-266
15894170-6	2005	Both NO donor and LPS/IFN-gamma markedly activated the PI3K activity and the phosphorylation of Akt and nuclear factor (NF)-kappaB DNA binding activity in mesangial cells, which could be inhibited by LY294002 and transfection of dominant-negative vectors of PI3K/p85 and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	AKT serine/threonine kinase 1	Homo sapiens	271-274
15946993-5	2005	Perfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 or wortmannin just before and concomitant with EPO treatment attenuated EPO-induced phosphorylation of the PI3K substrate Akt but had no effect on EPO-mediated cardioprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	erythropoietin	Rattus norvegicus	123-126
15946993-5	2005	Perfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 or wortmannin just before and concomitant with EPO treatment attenuated EPO-induced phosphorylation of the PI3K substrate Akt but had no effect on EPO-mediated cardioprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	erythropoietin	Rattus norvegicus	148-151
15946993-5	2005	Perfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 or wortmannin just before and concomitant with EPO treatment attenuated EPO-induced phosphorylation of the PI3K substrate Akt but had no effect on EPO-mediated cardioprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Rattus norvegicus	198-201
15946993-5	2005	Perfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 or wortmannin just before and concomitant with EPO treatment attenuated EPO-induced phosphorylation of the PI3K substrate Akt but had no effect on EPO-mediated cardioprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	erythropoietin	Rattus norvegicus	148-151
15801908-4	2005	The PI3K inhibitors LY294002 and wortmannin blocked IGF-I-stimulated Akt phosphorylation without blocking ERK phosphorylation and this was associated with complete inhibition of proteoglycan synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	69-72
16150575-10	2005	Carbamazepine-increased EAAT3 activity was inhibited by wortmannin or LY-294002, phosphatidylinositol 3-kinase (PI3K) inhibitors, but was not affected by staurosporine, chelerythrine or calphostin C, protein kinase C inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-79	solute carrier family 1 member 1	Rattus norvegicus	24-29
16061664-9	2005	p70 S6 kinase (p70 S6K) was activated by Ang1-treatment, although this activation was blocked by a PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	15-22
16061664-9	2005	p70 S6 kinase (p70 S6K) was activated by Ang1-treatment, although this activation was blocked by a PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	41-45
15971170-10	2005	This induction could be blocked with an anti-VEGF monoclonal antibody and by inhibitors of phosphatidylinositol 3-kinase (LY294002) or p38 mitogen-activated protein kinase (SB203580), but not by PD98059, a mitogen-activated protein/extracellular signal-regulated kinase 1 inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	vascular endothelial growth factor A	Homo sapiens	45-49
15953564-6	2005	The stimulation by bupleuran 2IIc/PG-1 of cyclin D2 expression was significantly decreased by inhibitors, PI 3-kinase (LY294002 and Wortmannin), PLCgamma (U73122), PKC (H-7), receptor-operated calcium entry inhibitor (SK&amp;F 96365), and calcineurin (FK506).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	cyclin D2	Mus musculus	42-51
16034129-2	2005	We previously reported that TNF in combination with LY294002, a PI3K inhibitor, activates caspase-independent cell death initiated by cathepsin B (Cat B) in HUVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	cathepsin B	Homo sapiens	134-145
16034129-2	2005	We previously reported that TNF in combination with LY294002, a PI3K inhibitor, activates caspase-independent cell death initiated by cathepsin B (Cat B) in HUVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	cathepsin B	Homo sapiens	147-152
16034129-4	2005	Like LY294002, IFN-gamma triggers Cat B release from lysosomes in HUVEC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	cathepsin B	Homo sapiens	34-39
15744749-5	2005	Pretreatment of human breast cancer cells with wortmannin or LY294002, selective inhibitors of phosphoinositide 3-kinase (PI3K), diminished Cch-mediated MAPK/ERK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	mitogen-activated protein kinase 1	Homo sapiens	158-161
15879002-7	2005	LY294002 completely inhibited Akt phosphorylation but partially blocked the phosphorylation of CREB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	30-33
15879002-7	2005	LY294002 completely inhibited Akt phosphorylation but partially blocked the phosphorylation of CREB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cAMP responsive element binding protein 1	Rattus norvegicus	95-99
15879002-10	2005	Preperfusing the hearts with LY294002 and PD098059 together completely abolished the phosphorylation of CREB, simultaneously inhibiting resveratrol-mediated cardioprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	cAMP responsive element binding protein 1	Rattus norvegicus	104-108
15843490-5	2005	After treatment with phosphatidylinositol 3-kinase (PI3K) inhibitors, internalization of stably transfected BCRP from the apical surface was observed after immunohistochemical staining, and the relative expression level of BCRP on the cell surface decreased to 49 +/- 14 and 51 +/- 8% of the control for LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride] and wortmannin treatment, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	304-312	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	108-112
16077404-3	2005	Exposure of mesothelioma cell lines to LY294002, a phosphoinositide-3 kinase inhibitor, results in apoptotic cell death and decreased phosphorylated Akt in vitro and tumor burden reduction in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	149-152
15845746-8	2005	Conversely, inhibition of phosphoinositide 3 kinase by LY294002 or Wortmanin reversed the E2-induced GSK-3beta Ser9 inhibitory phosphorylation and blocked nuclear accumulation of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	glycogen synthase kinase 3 beta	Homo sapiens	101-110
15845746-8	2005	Conversely, inhibition of phosphoinositide 3 kinase by LY294002 or Wortmanin reversed the E2-induced GSK-3beta Ser9 inhibitory phosphorylation and blocked nuclear accumulation of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	cyclin D1	Homo sapiens	179-188
15893751-4	2005	LPA induced p85 beta-PIX binding to FAK in NIH-3T3 cells that was inhibited by pretreatment of the cells with phosphoinositide 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	phosphoinositide-3-kinase regulatory subunit 2	Mus musculus	12-20
15893751-4	2005	LPA induced p85 beta-PIX binding to FAK in NIH-3T3 cells that was inhibited by pretreatment of the cells with phosphoinositide 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	Rho guanine nucleotide exchange factor (GEF7)	Mus musculus	21-24
15893751-4	2005	LPA induced p85 beta-PIX binding to FAK in NIH-3T3 cells that was inhibited by pretreatment of the cells with phosphoinositide 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	PTK2 protein tyrosine kinase 2	Mus musculus	36-39
16024628-1	2005	The phosphoinositide 3-kinase (PI3K)-Akt pathway is constitutively active in many tumors, and inhibitors of this prosurvival network, such as LY294002, have been shown to sensitize tumor cells to death stimuli.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	AKT serine/threonine kinase 1	Homo sapiens	37-40
15899884-6	2005	Interestingly, the down-regulation of SNAT3 expression by insulin was blocked by the specific phosphoinositide 3-kinase inhibitor LY294002 and mammalian target of rapamycin inhibitor, but not by MAPK inhibitor PD98059, suggesting that insulin exerts its effect on SNAT3 through phosphoinositide 3-kinase-mammalian target of rapamycin signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	solute carrier family 38 member 3	Homo sapiens	38-43
15899884-6	2005	Interestingly, the down-regulation of SNAT3 expression by insulin was blocked by the specific phosphoinositide 3-kinase inhibitor LY294002 and mammalian target of rapamycin inhibitor, but not by MAPK inhibitor PD98059, suggesting that insulin exerts its effect on SNAT3 through phosphoinositide 3-kinase-mammalian target of rapamycin signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	insulin	Homo sapiens	58-65
16014032-10	2005	We also found that LY294002 and rapamycin blocked Gas6-induced activation of the Akt/mTOR pathway and mesangial hypertrophy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	growth arrest specific 6	Mus musculus	50-54
16014032-10	2005	We also found that LY294002 and rapamycin blocked Gas6-induced activation of the Akt/mTOR pathway and mesangial hypertrophy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	thymoma viral proto-oncogene 1	Mus musculus	81-84
16014032-10	2005	We also found that LY294002 and rapamycin blocked Gas6-induced activation of the Akt/mTOR pathway and mesangial hypertrophy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	mechanistic target of rapamycin kinase	Mus musculus	85-89
16123141-8	2005	Furthermore, treatment of WM239 cells with LY294002 reduces RNF11/14-3-3 interactions suggesting that RNF11/14-3-3 binding is regulated by AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	ring finger protein 11	Homo sapiens	60-65
16123141-8	2005	Furthermore, treatment of WM239 cells with LY294002 reduces RNF11/14-3-3 interactions suggesting that RNF11/14-3-3 binding is regulated by AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	ring finger protein 11	Homo sapiens	102-107
16123141-8	2005	Furthermore, treatment of WM239 cells with LY294002 reduces RNF11/14-3-3 interactions suggesting that RNF11/14-3-3 binding is regulated by AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	139-142
15998322-2	2005	Using the phosphatase and tensin homolog-null LNCaP cells and the phosphatidylinositol 3-kinase inhibitor LY294002, we show that the phosphorylation of endogenous JFC1 is dependent on the phosphatidylinositol 3-kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	synaptotagmin like 1	Homo sapiens	163-167
16009787-10	2005	In contrast, histamine-stimulated TF expression was increased by phosphatidylinositol 3-kinase inhibition with LY294002 or wortmannin, whereas it was not affected by Rho-kinase inhibition with Y-27632 or hydroxyfasudil.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	coagulation factor III, tissue factor	Homo sapiens	34-36
16024610-8	2005	NO treatment also induced the phosphorylation of p53 at Ser15; pretreatment with phosphoinositide-3 kinase (PI3K) family inhibitors, wortmannin, LY294002, and caffeine, blocked such phosphorylation, but the p38 mitogen-activated protein kinase inhibitor, SB203580, did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	tumor protein p53	Homo sapiens	49-52
16024610-8	2005	NO treatment also induced the phosphorylation of p53 at Ser15; pretreatment with phosphoinositide-3 kinase (PI3K) family inhibitors, wortmannin, LY294002, and caffeine, blocked such phosphorylation, but the p38 mitogen-activated protein kinase inhibitor, SB203580, did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	mitogen-activated protein kinase 14	Homo sapiens	207-210
15931671-11	2005	Blocking of the PI3K/Akt pathway with either a pharmacological inhibitor of PI3K, LY294002, or dominant negative mutants of PI3K and Akt inhibited the membrane depolarization-induced increase in MEF2 transactivation as well as its DNA binding activity and reduced neuronal survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Rattus norvegicus	21-24
15940673-3	2005	First, treatment of monocyte-derived dendritic cells (DC) with wortmannin or LY294002 was found to enhance IFN-beta expression upon TLR3 or TLR4 engagement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	interferon beta 1	Homo sapiens	107-115
15845624-6	2005	In contrast, inhibition of the phosphatidylinositol-3 kinase signaling pathway by LY294002 abrogated both IGF-I-stimulated IGFBP-3 and -5 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	insulin-like growth factor 1	Rattus norvegicus	106-111
15845624-6	2005	In contrast, inhibition of the phosphatidylinositol-3 kinase signaling pathway by LY294002 abrogated both IGF-I-stimulated IGFBP-3 and -5 mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	insulin-like growth factor binding protein 3	Rattus norvegicus	123-137
21432138-4	2005	METHODS: The inhibitory effects of dibutyryl cAMP (db-cAMP) or LY294002 (a specific inhibitor of the PI3-kinase/Akt pathway) on DHA-induced apoptosis in HL-60 cells were evaluated by the appearance of apoptosis, and from the activities of caspases (3 and 8), the phospholylation of Akt, and cleavage of Bid using DNA indexes, emzymatic measurement of fragmented substrates, and Western blotting, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	AKT serine/threonine kinase 1	Homo sapiens	112-115
21432138-6	2005	However, the inhibition of PI3-kinase/Akt signaling by LY294002 resulted in recovery of the caspases" activities, appearance of apoptotic cells, and cleavage of the Bid molecule when LY294002 was co-treated with db-cAMP before the occurrence of DHA-induced apoptosis in HL-60.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Homo sapiens	38-41
21432138-6	2005	However, the inhibition of PI3-kinase/Akt signaling by LY294002 resulted in recovery of the caspases" activities, appearance of apoptotic cells, and cleavage of the Bid molecule when LY294002 was co-treated with db-cAMP before the occurrence of DHA-induced apoptosis in HL-60.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	BH3 interacting domain death agonist	Homo sapiens	165-168
21432138-6	2005	However, the inhibition of PI3-kinase/Akt signaling by LY294002 resulted in recovery of the caspases" activities, appearance of apoptotic cells, and cleavage of the Bid molecule when LY294002 was co-treated with db-cAMP before the occurrence of DHA-induced apoptosis in HL-60.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	AKT serine/threonine kinase 1	Homo sapiens	38-41
21432138-6	2005	However, the inhibition of PI3-kinase/Akt signaling by LY294002 resulted in recovery of the caspases" activities, appearance of apoptotic cells, and cleavage of the Bid molecule when LY294002 was co-treated with db-cAMP before the occurrence of DHA-induced apoptosis in HL-60.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	BH3 interacting domain death agonist	Homo sapiens	165-168
21432138-7	2005	It was also confirmed that LY294002 strongly inhibited phospholylation of Akt during db-cAMP induced-reduction of DHA-induced apoptosis in HL-60.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	74-77
15940673-3	2005	First, treatment of monocyte-derived dendritic cells (DC) with wortmannin or LY294002 was found to enhance IFN-beta expression upon TLR3 or TLR4 engagement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	toll like receptor 3	Homo sapiens	132-136
15940673-3	2005	First, treatment of monocyte-derived dendritic cells (DC) with wortmannin or LY294002 was found to enhance IFN-beta expression upon TLR3 or TLR4 engagement.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	toll like receptor 4	Homo sapiens	140-144
15797869-5	2005	This neuroprotective effect of NT-3 was concomitant to an increased level of Akt phosphorylation and was abolished by an inhibitor of the phosphatidylinositol-3 kinase (PI-3K), LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	neurotrophin 3	Homo sapiens	31-35
15946254-5	2005	The LTA-induced Akt activation was inhibited by wortmannin, LY 294002, genistein, and tyrphostin AG126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-69	AKT serine/threonine kinase 1	Homo sapiens	16-19
15946254-6	2005	The LTA-induced p38 MAPK activation was inhibited by genistein, tyrphostin AG126, wortmannin, LY 294002, and SB 203580.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-103	mitogen-activated protein kinase 14	Homo sapiens	16-19
15942663-0	2005	GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	glycogen synthase kinase 3 beta	Homo sapiens	0-9
15942663-3	2005	Here, we examined the molecular mechanisms whereby the PI3K inhibitor LY294002 sensitized p53- and Fas-deficient hepatoma cells to etoposide and camptothecin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	tumor protein p53	Homo sapiens	90-93
15942663-4	2005	LY294002 increased Hep3B cell susceptibility to chemotherapy-induced apoptosis by enhancing the expression of DR4 and DR5 and the activation of caspase-8 and -3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	major histocompatibility complex, class II, DR beta 4	Homo sapiens	110-113
15942663-4	2005	LY294002 increased Hep3B cell susceptibility to chemotherapy-induced apoptosis by enhancing the expression of DR4 and DR5 and the activation of caspase-8 and -3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	TNF receptor superfamily member 10b	Homo sapiens	118-121
15942663-4	2005	LY294002 increased Hep3B cell susceptibility to chemotherapy-induced apoptosis by enhancing the expression of DR4 and DR5 and the activation of caspase-8 and -3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 8	Homo sapiens	144-160
15942663-5	2005	Moreover, LY294002-mediated sensitization to chemotherapy involved mitochondrial Bax translocation and cytosolic cytochrome c accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	BCL2 associated X, apoptosis regulator	Homo sapiens	81-84
15942663-5	2005	Moreover, LY294002-mediated sensitization to chemotherapy involved mitochondrial Bax translocation and cytosolic cytochrome c accumulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	cytochrome c, somatic	Homo sapiens	113-125
15942663-6	2005	In Hep3B cells, LY294002 led to the reactivation of glycogen synthase kinase-3beta (GSK-3beta) by promoting its dephosphorylation on the serine 9 residue independently from Akt inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	glycogen synthase kinase 3 beta	Homo sapiens	52-82
15942663-6	2005	In Hep3B cells, LY294002 led to the reactivation of glycogen synthase kinase-3beta (GSK-3beta) by promoting its dephosphorylation on the serine 9 residue independently from Akt inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	glycogen synthase kinase 3 beta	Homo sapiens	84-93
15942663-7	2005	The transient transfection of a constitutively active and non-phosphorylable S9AGSK-3beta mutant sensitized cells to etoposide cytotoxic effects while cell treatment with the small GSK-3beta inhibitor SB-415286 repressed the sensitizing effect of LY294002 on chemotherapy-induced apoptosis and caspase-8 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	247-255	glycogen synthase kinase 3 beta	Homo sapiens	80-89
15863506-8	2005	Importantly, TPO and G(i) activation of integrin alpha(IIb)beta(3) was suppressed by wortmannin and Ly294002, suggesting a critical regulation by phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	thrombopoietin	Homo sapiens	13-16
15797869-5	2005	This neuroprotective effect of NT-3 was concomitant to an increased level of Akt phosphorylation and was abolished by an inhibitor of the phosphatidylinositol-3 kinase (PI-3K), LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	138-167
15800029-5	2005	LY294002 or wortmannin, inhibitors of PI-3K, suppressed LPS-induced Akt activity and MMP-9 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	68-71
15800029-5	2005	LY294002 or wortmannin, inhibitors of PI-3K, suppressed LPS-induced Akt activity and MMP-9 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	matrix metallopeptidase 9	Homo sapiens	85-90
15833899-7	2005	Furthermore, inactivation of PI3K with LY294002 [2-(4morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] blocked suramin-induced RPTC outgrowth, scattering, and proliferation, whereas blockade of ERK1/2 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	mitogen-activated protein kinase 3	Homo sapiens	189-195
16342423-7	2005	Pretreatment with LY294002, a specific inhibitor of PI3 kinase, blocked IGF1-stimulated Erk1/Erk2 activity; therefore, PI3 kinase may also be required for IGF1-dependent protein synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	insulin-like growth factor 1	Rattus norvegicus	72-76
15882878-4	2005	A specific inhibitor of PI3-kinase, LY294002, is used to block Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	63-66
15882878-8	2005	Blockade of Akt phosphorylation with LY294002 abrogates the effects of VEGF upon survivin and phosphorylated Akt protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	12-15
15882878-8	2005	Blockade of Akt phosphorylation with LY294002 abrogates the effects of VEGF upon survivin and phosphorylated Akt protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	vascular endothelial growth factor A	Homo sapiens	71-75
15882878-8	2005	Blockade of Akt phosphorylation with LY294002 abrogates the effects of VEGF upon survivin and phosphorylated Akt protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	109-112
15985761-6	2005	TRAIL (100 ng/ml) with LY 294002 (20 micromol/l) activated the extrinsic pathway, causing progressive cleavage of caspase-8 and caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-32	TNF superfamily member 10	Homo sapiens	0-5
15985761-6	2005	TRAIL (100 ng/ml) with LY 294002 (20 micromol/l) activated the extrinsic pathway, causing progressive cleavage of caspase-8 and caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-32	caspase 8	Homo sapiens	114-123
15985761-6	2005	TRAIL (100 ng/ml) with LY 294002 (20 micromol/l) activated the extrinsic pathway, causing progressive cleavage of caspase-8 and caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-32	caspase 3	Homo sapiens	128-137
16342423-7	2005	Pretreatment with LY294002, a specific inhibitor of PI3 kinase, blocked IGF1-stimulated Erk1/Erk2 activity; therefore, PI3 kinase may also be required for IGF1-dependent protein synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	mitogen activated protein kinase 3	Rattus norvegicus	88-92
15817703-10	2005	The ability of KT5720 and St-Ht31 to stimulate migration was abolished by pretreatment with the phosphatidylinositol-3 kinase (PI-3K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	96-125
16342423-7	2005	Pretreatment with LY294002, a specific inhibitor of PI3 kinase, blocked IGF1-stimulated Erk1/Erk2 activity; therefore, PI3 kinase may also be required for IGF1-dependent protein synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	mitogen activated protein kinase 1	Rattus norvegicus	93-97
16342423-7	2005	Pretreatment with LY294002, a specific inhibitor of PI3 kinase, blocked IGF1-stimulated Erk1/Erk2 activity; therefore, PI3 kinase may also be required for IGF1-dependent protein synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	insulin-like growth factor 1	Rattus norvegicus	155-159
15975520-6	2005	Treatment with the phosphatidylinositol 3"-kinase (PBK) inhibitor LY294002 resulted in ICAM-5 down-regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	PDZ binding kinase	Homo sapiens	51-54
15975520-6	2005	Treatment with the phosphatidylinositol 3"-kinase (PBK) inhibitor LY294002 resulted in ICAM-5 down-regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	intercellular adhesion molecule 5	Homo sapiens	87-93
15678501-8	2005	Furthermore, the IL-4-induced NF-kappaB activation and nuclear translocation can be blocked by LY294002, a PI3K/Akt specific inhibitor, suggesting that IL-4-induced NF-(kappa)B activation is mediated by activation of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	interleukin 4	Homo sapiens	17-21
15678501-8	2005	Furthermore, the IL-4-induced NF-kappaB activation and nuclear translocation can be blocked by LY294002, a PI3K/Akt specific inhibitor, suggesting that IL-4-induced NF-(kappa)B activation is mediated by activation of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	112-115
15678501-8	2005	Furthermore, the IL-4-induced NF-kappaB activation and nuclear translocation can be blocked by LY294002, a PI3K/Akt specific inhibitor, suggesting that IL-4-induced NF-(kappa)B activation is mediated by activation of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	interleukin 4	Homo sapiens	152-156
15678501-8	2005	Furthermore, the IL-4-induced NF-kappaB activation and nuclear translocation can be blocked by LY294002, a PI3K/Akt specific inhibitor, suggesting that IL-4-induced NF-(kappa)B activation is mediated by activation of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	nuclear factor kappa B subunit 1	Homo sapiens	165-176
15678501-8	2005	Furthermore, the IL-4-induced NF-kappaB activation and nuclear translocation can be blocked by LY294002, a PI3K/Akt specific inhibitor, suggesting that IL-4-induced NF-(kappa)B activation is mediated by activation of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	222-225
15944287-6	2005	By using specific inhibitors for PI3K (LY294002) and ERK MAPKs (PD98059), we demonstrate that LY294002 either alone or in conjunction with PD98059 inhibited IL-10-induced phosphorylation of STAT-1 and consequently CD14 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	interleukin 10	Homo sapiens	157-162
16000874-3	2005	We also found that the inhibition of anoikis by COX-2 results from activation of the PI-3K/Akt pathway as evidenced by suppression of the COX-2 effect on anoikis by a PI-3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	prostaglandin-endoperoxide synthase 2	Homo sapiens	48-53
15806152-5	2005	Pharmacologic inhibition of phosphatidylinositol 3-kinase with LY294002 reduced the HIF-1alpha level in both normoxic and hypoxic A431 cells, whereas inhibition of the mitogen-activated protein kinase kinase by PD98059 reduced the level of HIF-1alpha only in normoxic A431 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-94
15806152-5	2005	Pharmacologic inhibition of phosphatidylinositol 3-kinase with LY294002 reduced the HIF-1alpha level in both normoxic and hypoxic A431 cells, whereas inhibition of the mitogen-activated protein kinase kinase by PD98059 reduced the level of HIF-1alpha only in normoxic A431 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	hypoxia inducible factor 1 subunit alpha	Homo sapiens	240-250
15894110-0	2005	LY294002 inhibits LPS-induced NO production through a inhibition of NF-kappaB activation: independent mechanism of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	115-144
15894110-4	2005	At the same concentrations, LY294002, but not wortmannin, significantly inhibited NO production and iNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	nitric oxide synthase 2, inducible	Mus musculus	100-104
15894110-7	2005	These results suggest that LY294002 inhibits iNOS expression at least in part via inhibition of NF-kappaB activation, independent of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	nitric oxide synthase 2, inducible	Mus musculus	45-49
15964826-4	2005	Inactivation of Akt by chemotherapeutic drugs or the phosphatidylinositide-3-OH kinase inhibitor LY294002 induced G2/M arrest together with the inhibitory phosphorylation of Cdc2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	16-19
15964826-4	2005	Inactivation of Akt by chemotherapeutic drugs or the phosphatidylinositide-3-OH kinase inhibitor LY294002 induced G2/M arrest together with the inhibitory phosphorylation of Cdc2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	cyclin dependent kinase 1	Homo sapiens	174-178
16000874-3	2005	We also found that the inhibition of anoikis by COX-2 results from activation of the PI-3K/Akt pathway as evidenced by suppression of the COX-2 effect on anoikis by a PI-3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	AKT serine/threonine kinase 1	Homo sapiens	91-94
16000874-3	2005	We also found that the inhibition of anoikis by COX-2 results from activation of the PI-3K/Akt pathway as evidenced by suppression of the COX-2 effect on anoikis by a PI-3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	prostaglandin-endoperoxide synthase 2	Homo sapiens	138-143
15882976-6	2005	LY294002 and U0126, pharmacological inhibitors of phosphatidylinositol 3-kinase and MEK1/2 which are upstream of Akt and ERK1/2, respectively, attenuated resveratrol-induced HO-1 expression and exhibited antioxidant effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen activated protein kinase kinase 1	Rattus norvegicus	84-90
15882976-6	2005	LY294002 and U0126, pharmacological inhibitors of phosphatidylinositol 3-kinase and MEK1/2 which are upstream of Akt and ERK1/2, respectively, attenuated resveratrol-induced HO-1 expression and exhibited antioxidant effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	113-116
15882976-6	2005	LY294002 and U0126, pharmacological inhibitors of phosphatidylinositol 3-kinase and MEK1/2 which are upstream of Akt and ERK1/2, respectively, attenuated resveratrol-induced HO-1 expression and exhibited antioxidant effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen activated protein kinase 3	Rattus norvegicus	121-127
15882976-6	2005	LY294002 and U0126, pharmacological inhibitors of phosphatidylinositol 3-kinase and MEK1/2 which are upstream of Akt and ERK1/2, respectively, attenuated resveratrol-induced HO-1 expression and exhibited antioxidant effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heme oxygenase 1	Rattus norvegicus	174-178
15896702-5	2005	The AVP-induced HSP27 phosphorylation was attenuated by LY294002, a PI3K inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	heat shock protein family B (small) member 1	Homo sapiens	16-21
15894115-5	2005	CSB-induced B cell proliferation was almost completely blocked by either the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 or the PKC inhibitor GF109203X but was not significantly inhibited by the ERK kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	excision repair cross-complementing rodent repair deficiency, complementation group 6	Mus musculus	0-3
15894115-5	2005	CSB-induced B cell proliferation was almost completely blocked by either the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 or the PKC inhibitor GF109203X but was not significantly inhibited by the ERK kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	77-106
15944287-6	2005	By using specific inhibitors for PI3K (LY294002) and ERK MAPKs (PD98059), we demonstrate that LY294002 either alone or in conjunction with PD98059 inhibited IL-10-induced phosphorylation of STAT-1 and consequently CD14 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	signal transducer and activator of transcription 1	Homo sapiens	190-196
15944287-6	2005	By using specific inhibitors for PI3K (LY294002) and ERK MAPKs (PD98059), we demonstrate that LY294002 either alone or in conjunction with PD98059 inhibited IL-10-induced phosphorylation of STAT-1 and consequently CD14 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	CD14 molecule	Homo sapiens	214-218
15826941-6	2005	Treatment of cells with LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), also abrogated the PDGF-induced lamellipodia formation and cell migration, suggesting that PI3K may be required for WAVE3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	50-79
15797857-6	2005	Sodium orthovanadate, chondroitin sulfate-C, PP1, wortmannin, LY294002, and U0126 inhibit HARP-mediated signaling and HUVEC migration and tube formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	pleiotrophin	Homo sapiens	90-94
15797868-7	2005	Further studies indicated that LY294002, an inhibitor of phosphoinositide 3-kinase that is an upstream signaling protein of Akt1, could block neuroprotection of preconditioning, and KN62, an inhibitor of calmodulin-dependent protein kinase, also achieved the same effects as LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	124-128
15797868-7	2005	Further studies indicated that LY294002, an inhibitor of phosphoinositide 3-kinase that is an upstream signaling protein of Akt1, could block neuroprotection of preconditioning, and KN62, an inhibitor of calmodulin-dependent protein kinase, also achieved the same effects as LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	275-283	AKT serine/threonine kinase 1	Homo sapiens	124-128
15826941-6	2005	Treatment of cells with LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), also abrogated the PDGF-induced lamellipodia formation and cell migration, suggesting that PI3K may be required for WAVE3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	WASP family member 3	Homo sapiens	204-209
15805105-10	2005	Subsequent analysis revealed not only induction of Akt phosphorylation by recombinant beta ig-h3 but also blockage of Akt phosphorylation by LY294002, an inhibitor of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Homo sapiens	118-121
15922332-4	2005	Induction of PTTG mRNA expression by insulin or IGF-1 was completely blocked by the specific phosphatidylinositol (PI) 3 kinase inhibitor LY294002, but partially blocked by the MAP kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	13-17
15850772-2	2005	Inhibition of PI3K/Akt pathway with a selective inhibitor (e.g., LY294002, or wortmannin) in leukemic cells markedly potentiated fludarabine-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	19-22
15850772-4	2005	The co-treatment of fludarabine/LY294002 resulted in significant attenuation in the levels of both phospho-Erk1/2 and phospho-Akt, as well as a marked increase in the level of phospho-JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	126-129
15850772-4	2005	The co-treatment of fludarabine/LY294002 resulted in significant attenuation in the levels of both phospho-Erk1/2 and phospho-Akt, as well as a marked increase in the level of phospho-JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	mitogen-activated protein kinase 8	Homo sapiens	184-187
15850772-7	2005	Moreover, constitutive activation of the MEK/Erk pathway completely blocked apoptosis induced by the combination of fludarabine/LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	mitogen-activated protein kinase kinase 7	Homo sapiens	41-44
15850772-7	2005	Moreover, constitutive activation of the MEK/Erk pathway completely blocked apoptosis induced by the combination of fludarabine/LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	mitogen-activated protein kinase 1	Homo sapiens	45-48
15922332-4	2005	Induction of PTTG mRNA expression by insulin or IGF-1 was completely blocked by the specific phosphatidylinositol (PI) 3 kinase inhibitor LY294002, but partially blocked by the MAP kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	insulin like growth factor 1	Homo sapiens	48-53
15922332-4	2005	Induction of PTTG mRNA expression by insulin or IGF-1 was completely blocked by the specific phosphatidylinositol (PI) 3 kinase inhibitor LY294002, but partially blocked by the MAP kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	insulin	Homo sapiens	37-44
15782121-7	2005	However, Akt is released from the N-terminal domain concomitant with binding to the C-terminal domain of ASK1 in response to ASK1 activator H(2)O(2), inhibitor of Hsp90 17-AAG and Akt inhibitor LY294002, leading to a more stable Hsp90-Akt-ASK1 complex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	AKT serine/threonine kinase 1	Homo sapiens	9-12
15741161-11	2005	The targeting of PI3K ex vivo, using LY294002, restored sensitivity to TRAIL in recurrent tumor epithelia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	TNF superfamily member 10	Homo sapiens	71-76
15782121-4	2005	Thus, inhibition of Hsp90 by 17-allyamino-17-demethoxygeldanamycin (17-AAG) or phosphatidylinositol 3-kinase (PI3K) LY294002 induced and synergized ASK1 activation and ASK1-mediated EC apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	heat shock protein 90 alpha family class A member 1	Homo sapiens	20-25
15782121-7	2005	However, Akt is released from the N-terminal domain concomitant with binding to the C-terminal domain of ASK1 in response to ASK1 activator H(2)O(2), inhibitor of Hsp90 17-AAG and Akt inhibitor LY294002, leading to a more stable Hsp90-Akt-ASK1 complex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	105-109
15782121-4	2005	Thus, inhibition of Hsp90 by 17-allyamino-17-demethoxygeldanamycin (17-AAG) or phosphatidylinositol 3-kinase (PI3K) LY294002 induced and synergized ASK1 activation and ASK1-mediated EC apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	148-152
15782121-4	2005	Thus, inhibition of Hsp90 by 17-allyamino-17-demethoxygeldanamycin (17-AAG) or phosphatidylinositol 3-kinase (PI3K) LY294002 induced and synergized ASK1 activation and ASK1-mediated EC apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	168-172
15888030-7	2005	Downregulation of phospho-Akt at Thr 308 and Ser 473 was due to partial inhibition of PI3-kinase/Akt pathway by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Rattus norvegicus	26-29
15708965-8	2005	Moreover, preincubation of E47 cells with wortmannin or LY-294002 blocked FN-induced mTOR/S6K activation, demonstrating that phosphatidylinositol 3-kinase (PI3K) plays a critical role in this rapamycin-sensitive signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-65	fibronectin 1	Homo sapiens	74-76
15708965-8	2005	Moreover, preincubation of E47 cells with wortmannin or LY-294002 blocked FN-induced mTOR/S6K activation, demonstrating that phosphatidylinositol 3-kinase (PI3K) plays a critical role in this rapamycin-sensitive signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-65	tortured	Mus musculus	85-93
15691865-4	2005	We found that wortmannin and LY-294002, inhibitors of phosphatidylinositol 3-kinase (PI3-kinase) specifically inhibited the increase in fructose uptake rate and brush-border GLUT5 protein abundance but not GLUT5 mRNA abundance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-38	solute carrier family 2 member 5	Rattus norvegicus	174-179
15691865-4	2005	We found that wortmannin and LY-294002, inhibitors of phosphatidylinositol 3-kinase (PI3-kinase) specifically inhibited the increase in fructose uptake rate and brush-border GLUT5 protein abundance but not GLUT5 mRNA abundance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-38	solute carrier family 2 member 5	Rattus norvegicus	206-211
15888030-7	2005	Downregulation of phospho-Akt at Thr 308 and Ser 473 was due to partial inhibition of PI3-kinase/Akt pathway by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
15888030-8	2005	Activation of GSK-3beta and inactivation of caspase-12 and Bad could be found in the LY294002 groups in which the liver grafts showed less ischemic injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	glycogen synthase kinase 3 beta	Rattus norvegicus	14-23
15888030-8	2005	Activation of GSK-3beta and inactivation of caspase-12 and Bad could be found in the LY294002 groups in which the liver grafts showed less ischemic injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	caspase 12	Rattus norvegicus	44-54
15896333-7	2005	Erucin-induced phase II enzyme transcriptions were decreased by PI3K and MEK1 inhibitors (LY294002 and PD98059), but the decreases in sulforaphane-induced transcription were less marked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	mitogen-activated protein kinase kinase 1	Homo sapiens	73-77
15656793-7	2005	H11-KI activated Akt, and cardiac hypertrophy induced by H11-KI was blocked by LY294002, an inhibitor of phosphoinositide 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Rattus norvegicus	17-20
15947112-8	2005	Further, FSH and LH significantly increased activities of various kinases at 5-10 min, and pre-treatments with LY294002 (an inhibitor of PI3K) or PD98059 (an inhibitor of ERK1/2) partially blocked the gonadotropin-induced up-regulation of EGFR in IOSE-80PC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	mitogen-activated protein kinase 3	Homo sapiens	171-177
15950905-6	2005	Treatment with the PI3K inhibitor LY294002 abrogated PIK3CA signaling and preferentially inhibited growth of PIK3CA mutant cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	53-59
15950905-6	2005	Treatment with the PI3K inhibitor LY294002 abrogated PIK3CA signaling and preferentially inhibited growth of PIK3CA mutant cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	109-115
15947112-8	2005	Further, FSH and LH significantly increased activities of various kinases at 5-10 min, and pre-treatments with LY294002 (an inhibitor of PI3K) or PD98059 (an inhibitor of ERK1/2) partially blocked the gonadotropin-induced up-regulation of EGFR in IOSE-80PC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	epidermal growth factor receptor	Homo sapiens	239-243
15922325-3	2005	Honokiol-induced neurite outgrowth in the cultured rat cortical neurons was significantly reduced by PD98059, a mitogen-activated protein kinase kinase (MAPKK, MAPK/ERK kinase MEK, direct upstream of ERK1/2) inhibitor, but not by LY294002, a phosphoinositide 3-kinase (PI3K, upstream of Akt) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	230-238	mitogen activated protein kinase 3	Rattus norvegicus	200-206
15573401-5	2005	Inhibition of PI3-K by LY294002 attenuated BK-induced Akt and p42/p44 MAPK phosphorylation and [3H]thymidine incorporation, but had no effect on EGFR phosphorylation, suggesting that EGFR may be an upstream component of PI3-K/Akt and MAPK in these responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	kininogen 1	Homo sapiens	43-45
15940626-9	2005	K-ras(Val12) increased the stability of beta-catenin, the levels of nuclear beta-catenin, and the formation of nuclear beta-catenin/TCF-4 complexes, and these effects were also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	KRAS proto-oncogene, GTPase	Homo sapiens	0-5
15940626-9	2005	K-ras(Val12) increased the stability of beta-catenin, the levels of nuclear beta-catenin, and the formation of nuclear beta-catenin/TCF-4 complexes, and these effects were also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	catenin beta 1	Homo sapiens	40-52
15940626-9	2005	K-ras(Val12) increased the stability of beta-catenin, the levels of nuclear beta-catenin, and the formation of nuclear beta-catenin/TCF-4 complexes, and these effects were also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	catenin beta 1	Homo sapiens	76-88
15940626-9	2005	K-ras(Val12) increased the stability of beta-catenin, the levels of nuclear beta-catenin, and the formation of nuclear beta-catenin/TCF-4 complexes, and these effects were also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	catenin beta 1	Homo sapiens	76-88
15940626-9	2005	K-ras(Val12) increased the stability of beta-catenin, the levels of nuclear beta-catenin, and the formation of nuclear beta-catenin/TCF-4 complexes, and these effects were also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	transcription factor 7 like 2	Homo sapiens	132-137
15573401-5	2005	Inhibition of PI3-K by LY294002 attenuated BK-induced Akt and p42/p44 MAPK phosphorylation and [3H]thymidine incorporation, but had no effect on EGFR phosphorylation, suggesting that EGFR may be an upstream component of PI3-K/Akt and MAPK in these responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	54-57
15573401-5	2005	Inhibition of PI3-K by LY294002 attenuated BK-induced Akt and p42/p44 MAPK phosphorylation and [3H]thymidine incorporation, but had no effect on EGFR phosphorylation, suggesting that EGFR may be an upstream component of PI3-K/Akt and MAPK in these responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	cyclin dependent kinase 20	Homo sapiens	62-65
15573401-5	2005	Inhibition of PI3-K by LY294002 attenuated BK-induced Akt and p42/p44 MAPK phosphorylation and [3H]thymidine incorporation, but had no effect on EGFR phosphorylation, suggesting that EGFR may be an upstream component of PI3-K/Akt and MAPK in these responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	interferon induced protein 44	Homo sapiens	66-69
15880726-7	2005	Survival induced by L1 and CHL1 was completely inhibited by 20 microM LY294002 and PD98059, indicating that both MEK and PI3K pathways are required for signaling by these molecules.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	cell adhesion molecule L1-like	Rattus norvegicus	27-31
15930168-6	2005	The telomerase activity induced by GH was specifically blocked by the phosphatidylinositol 3"-kinase (PI3-K) inhibitor, LY294002, but not by the MAP kinase kinase inhibitor, PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	70-100
15934945-4	2005	U0126, a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, both inhibited FGF2-induced BrdU incorporation, suggesting that the extracellular signal-regulated kinase1/2 (ERK1/2) and PI3K pathways are required for FGF2-induced NP cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	89-118
15934941-5	2005	FoxO1 translocation was inhibited by LY294002, a well-established PI3K/Akt kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	forkhead box O1	Rattus norvegicus	0-5
15724079-8	2005	Treatment with 10(-7) M of the MAP kinase inhibitor PD098059 and 10(-5) M of the PI-3 kinase inhibitor LY294002 decreased IGF-I-induced BrdU-uptake in the endometrial stromal cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	insulin-like growth factor 1	Mus musculus	122-127
15934941-5	2005	FoxO1 translocation was inhibited by LY294002, a well-established PI3K/Akt kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Rattus norvegicus	71-74
15934945-4	2005	U0126, a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, both inhibited FGF2-induced BrdU incorporation, suggesting that the extracellular signal-regulated kinase1/2 (ERK1/2) and PI3K pathways are required for FGF2-induced NP cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	fibroblast growth factor 2	Homo sapiens	152-156
15934945-4	2005	U0126, a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, both inhibited FGF2-induced BrdU incorporation, suggesting that the extracellular signal-regulated kinase1/2 (ERK1/2) and PI3K pathways are required for FGF2-induced NP cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	mitogen-activated protein kinase 1	Homo sapiens	205-245
15934945-4	2005	U0126, a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, both inhibited FGF2-induced BrdU incorporation, suggesting that the extracellular signal-regulated kinase1/2 (ERK1/2) and PI3K pathways are required for FGF2-induced NP cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	mitogen-activated protein kinase 3	Homo sapiens	247-253
15934945-4	2005	U0126, a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, both inhibited FGF2-induced BrdU incorporation, suggesting that the extracellular signal-regulated kinase1/2 (ERK1/2) and PI3K pathways are required for FGF2-induced NP cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	fibroblast growth factor 2	Homo sapiens	290-294
15934945-6	2005	The inhibitory effect of NT3 on FGF2-induced NP cell proliferation was abolished by LY294002, and treatment with SB216763, a specific GSK3 inhibitor, antagonized the NT3 effect, rescuing both neurosphere growth and BrdU incorporation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	neurotrophin 3	Homo sapiens	25-28
15934945-6	2005	The inhibitory effect of NT3 on FGF2-induced NP cell proliferation was abolished by LY294002, and treatment with SB216763, a specific GSK3 inhibitor, antagonized the NT3 effect, rescuing both neurosphere growth and BrdU incorporation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	fibroblast growth factor 2	Homo sapiens	32-36
15792956-7	2005	However, pretreatment of cells with the DNA-protein kinase (PK) inhibitor LY294002 strongly reversed silibinin-enhanced Akt-Ser(473) and p53-Ser(15) as well as ERK1/2 phosphorylation together with a dose-dependent decrease in cleaved caspase 3 and apoptosis (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	thymoma viral proto-oncogene 1	Mus musculus	120-123
15922966-6	2005	Maturation of leukemic cells into APCs was mediated at least partially via a PI3K/mTOR pathway, as the inhibitors LY294002, wortmannin, and rapamycin inhibited the maturation effect induced by the AdTNF.F(pK7) adenovirus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	mechanistic target of rapamycin kinase	Homo sapiens	82-86
15968405-8	2005	Inhibition of either the PI3K by LY294002 or ERK1/2 by U0126 reduced HIF-1alpha protein levels while both inhibitors together completely abolished the IGF-1 effect on HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
15792956-7	2005	However, pretreatment of cells with the DNA-protein kinase (PK) inhibitor LY294002 strongly reversed silibinin-enhanced Akt-Ser(473) and p53-Ser(15) as well as ERK1/2 phosphorylation together with a dose-dependent decrease in cleaved caspase 3 and apoptosis (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	transformation related protein 53, pseudogene	Mus musculus	137-140
15792956-7	2005	However, pretreatment of cells with the DNA-protein kinase (PK) inhibitor LY294002 strongly reversed silibinin-enhanced Akt-Ser(473) and p53-Ser(15) as well as ERK1/2 phosphorylation together with a dose-dependent decrease in cleaved caspase 3 and apoptosis (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	mitogen-activated protein kinase 3	Mus musculus	160-166
15792956-8	2005	In addition, silibinin pretreatment strongly enhanced H2A.X-Ser(139) phosphorylation and DNA-PK-associated kinase activity as well as the physical interaction of p53 with DNA-PK; pretreatment of cells with LY294002 but not caffeine abolished the silibinin-caused increase in both DNA-PK activation and p53-Ser(15) phosphorylations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	206-214	transformation related protein 53, pseudogene	Mus musculus	302-305
15831817-5	2005	Treatment of ECs with PKA inhibitor H89 or PI3K inhibitor LY294002 prevented the AdE4+-mediated regulation of Cx40 and Cx43 that was associated with diminished AdE4+-mediated survival of ECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	gap junction protein, alpha 5	Mus musculus	110-114
15688415-8	2005	The patterns for NF-kappaB and calpain activities followed that of PI3K and were inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	nuclear factor kappa B subunit 1	Homo sapiens	17-26
15809062-9	2005	In addition, the PI3 kinase inhibitor, LY294002, upregulates IGFBP-3 expression but downregulates IGF-I and IGF-II, indicating that PTEN controls IGFBP-3 and IGFs by an Akt-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	insulin like growth factor binding protein 3	Homo sapiens	61-68
15809062-9	2005	In addition, the PI3 kinase inhibitor, LY294002, upregulates IGFBP-3 expression but downregulates IGF-I and IGF-II, indicating that PTEN controls IGFBP-3 and IGFs by an Akt-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	insulin like growth factor 1	Homo sapiens	98-103
15809062-9	2005	In addition, the PI3 kinase inhibitor, LY294002, upregulates IGFBP-3 expression but downregulates IGF-I and IGF-II, indicating that PTEN controls IGFBP-3 and IGFs by an Akt-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	insulin like growth factor 2	Homo sapiens	108-114
15806173-6	2005	Treatment with LY294002 abolished AKT activity and potentiated apoptosis induced by FAS inhibitors cerulenin or C75 only in cells with constitutively active AKT, suggesting that constitutive activation of AKT protects against FAS inhibitor-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	34-37
15806173-6	2005	Treatment with LY294002 abolished AKT activity and potentiated apoptosis induced by FAS inhibitors cerulenin or C75 only in cells with constitutively active AKT, suggesting that constitutive activation of AKT protects against FAS inhibitor-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	fatty acid synthase	Homo sapiens	84-87
15806173-6	2005	Treatment with LY294002 abolished AKT activity and potentiated apoptosis induced by FAS inhibitors cerulenin or C75 only in cells with constitutively active AKT, suggesting that constitutive activation of AKT protects against FAS inhibitor-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	157-160
15806173-6	2005	Treatment with LY294002 abolished AKT activity and potentiated apoptosis induced by FAS inhibitors cerulenin or C75 only in cells with constitutively active AKT, suggesting that constitutive activation of AKT protects against FAS inhibitor-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	157-160
15806173-6	2005	Treatment with LY294002 abolished AKT activity and potentiated apoptosis induced by FAS inhibitors cerulenin or C75 only in cells with constitutively active AKT, suggesting that constitutive activation of AKT protects against FAS inhibitor-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	fatty acid synthase	Homo sapiens	226-229
15809062-9	2005	In addition, the PI3 kinase inhibitor, LY294002, upregulates IGFBP-3 expression but downregulates IGF-I and IGF-II, indicating that PTEN controls IGFBP-3 and IGFs by an Akt-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	phosphatase and tensin homolog	Homo sapiens	132-136
15809062-9	2005	In addition, the PI3 kinase inhibitor, LY294002, upregulates IGFBP-3 expression but downregulates IGF-I and IGF-II, indicating that PTEN controls IGFBP-3 and IGFs by an Akt-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	insulin like growth factor binding protein 3	Homo sapiens	146-153
15831817-5	2005	Treatment of ECs with PKA inhibitor H89 or PI3K inhibitor LY294002 prevented the AdE4+-mediated regulation of Cx40 and Cx43 that was associated with diminished AdE4+-mediated survival of ECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	gap junction protein, alpha 3	Mus musculus	119-123
15809062-9	2005	In addition, the PI3 kinase inhibitor, LY294002, upregulates IGFBP-3 expression but downregulates IGF-I and IGF-II, indicating that PTEN controls IGFBP-3 and IGFs by an Akt-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	169-172
15613495-3	2005	Stretch-induced IKK activation and IL-6 secretion were inhibited by application of alpha(5)beta(1) integrin-inhibitory peptide (GRGDNP), phosphatidylinositol 3-kinase inhibitor (LY-294002), phospholipase C-gamma inhibitor (U-73122), or protein kinase C inhibitor (H7).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-187	interleukin 6	Homo sapiens	35-39
15735664-9	2005	Furthermore, treatment with 10 microM of phosphatidylinositol 3 (PI3) kinase inhibitor, LY294002, abrogates HGF-induced cell scattering of SHIP-2-overexpressing cells but not parental HEK293 cells, suggesting that a balance between PI3 kinase and SHIP is important for cell motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	hepatocyte growth factor	Homo sapiens	108-111
15735664-9	2005	Furthermore, treatment with 10 microM of phosphatidylinositol 3 (PI3) kinase inhibitor, LY294002, abrogates HGF-induced cell scattering of SHIP-2-overexpressing cells but not parental HEK293 cells, suggesting that a balance between PI3 kinase and SHIP is important for cell motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	inositol polyphosphate phosphatase like 1	Homo sapiens	139-145
15735664-9	2005	Furthermore, treatment with 10 microM of phosphatidylinositol 3 (PI3) kinase inhibitor, LY294002, abrogates HGF-induced cell scattering of SHIP-2-overexpressing cells but not parental HEK293 cells, suggesting that a balance between PI3 kinase and SHIP is important for cell motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	inositol polyphosphate-5-phosphatase D	Homo sapiens	139-143
15879099-6	2005	All these TGF-beta-mediated effects are prevented by PTX-B or PT9K/129G through a PI3K-dependent mechanism, as demonstrated by use of the specific PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	transforming growth factor beta 1	Homo sapiens	10-18
15956717-9	2005	Treatment of THP-1 or MMC cells with the PI3K inhibitor, LY294002, abolished the relaxin-mediated stimulation of VEGF transcript levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	GLI family zinc finger 2	Homo sapiens	13-18
15965068-11	2005	On the other hand, LY 294002, a phosphatidylinositol 3-kinase (PI-3K)-specific inhibitor, prevented the enhancement of HO-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	heme oxygenase 1	Homo sapiens	119-123
15956717-9	2005	Treatment of THP-1 or MMC cells with the PI3K inhibitor, LY294002, abolished the relaxin-mediated stimulation of VEGF transcript levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	vascular endothelial growth factor A	Homo sapiens	113-117
15971148-5	2005	LY294002 and wortmannin, inhibitors of phosphatidylinositol 3-kinase, significantly suppressed the IGF-I-induced alkaline phosphatase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin-like growth factor 1	Mus musculus	99-104
15971148-6	2005	The phosphorylation of Akt induced by IGF-I was markedly reduced by LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	thymoma viral proto-oncogene 1	Mus musculus	23-26
15971148-6	2005	The phosphorylation of Akt induced by IGF-I was markedly reduced by LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	insulin-like growth factor 1	Mus musculus	38-43
15857405-11	2005	We also noted that pretreatment of LY294002 before preconditioning reversed both the inhibition of MLK3 activation at 6 h of reperfusion and the increase in Akt1 activation at 10 min of reperfusion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Rattus norvegicus	157-161
15843522-6	2005	LY294002, an inhibitor of PI3K, abolished expression of hTERT mRNA and protein expression and abolished hTERT activity, whereas PD98059, which inhibits MEK1/2 and thus ERK1/2, had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	telomerase reverse transcriptase	Homo sapiens	56-61
15843522-6	2005	LY294002, an inhibitor of PI3K, abolished expression of hTERT mRNA and protein expression and abolished hTERT activity, whereas PD98059, which inhibits MEK1/2 and thus ERK1/2, had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	telomerase reverse transcriptase	Homo sapiens	104-109
15661829-5	2005	The Fc gammaRIIIB-induced increase of beta2 integrins required Src-family tyrosine kinases, Syk kinase, and phosphatidylinositol-3 kinase (PI-3K), as the corresponding, specific inhibitors, PP2, Piceatannol, and LY294002, completely blocked it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	Fc gamma receptor IIIb	Homo sapiens	4-17
15661829-5	2005	The Fc gammaRIIIB-induced increase of beta2 integrins required Src-family tyrosine kinases, Syk kinase, and phosphatidylinositol-3 kinase (PI-3K), as the corresponding, specific inhibitors, PP2, Piceatannol, and LY294002, completely blocked it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	38-43
15857394-7	2005	Activation of Akt was also inhibited by pretreatment with pertussis toxin as well as the phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	AKT serine/threonine kinase 1	Homo sapiens	14-17
16013009-9	2005	The Akt/PI3K inhibitor, LY 294002, blocked this potentiation, related to increased eNOS activity rather than eNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-33	AKT serine/threonine kinase 1	Bos taurus	4-7
15857405-11	2005	We also noted that pretreatment of LY294002 before preconditioning reversed both the inhibition of MLK3 activation at 6 h of reperfusion and the increase in Akt1 activation at 10 min of reperfusion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	mitogen-activated protein kinase kinase kinase 11	Rattus norvegicus	99-103
15626746-6	2005	BCR/ABL-dependent expression of MCL-1 in Ba/F3 cells was counteracted by the mitogen-activated protein-kinase/extracellular signal-regulated kinase (MEK) inhibitor, PD98059, but not by the phosphoinositide 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	226-234	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-7
29350792-5	2005	The FcgammaRIIIB-induced increase of beta2 integrins required Src-family tyrosine kinases, Syk kinase, and phosphatidylinositol-3 kinase (PI-3K), as the corresponding, specific inhibitors, PP2, Piceatannol, and LY294002, completely blocked it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	211-219	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	37-42
15791648-7	2005	The inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt signaling by LY294002 increased the Erk activation induced by the mutant B-raf proteins, as well as by wild-type B-raf.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	55-58
15791648-7	2005	The inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt signaling by LY294002 increased the Erk activation induced by the mutant B-raf proteins, as well as by wild-type B-raf.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	mitogen-activated protein kinase 1	Homo sapiens	95-98
15791648-7	2005	The inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt signaling by LY294002 increased the Erk activation induced by the mutant B-raf proteins, as well as by wild-type B-raf.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	132-137
15684417-8	2005	Moreover, TRAIL-induced RA FLS proliferation was inhibited by the protein kinase inhibitors PD98059, SB203580, and LY294002, confirming the involvement of the ERK, p38, and PI3 kinase/Akt signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	TNF superfamily member 10	Homo sapiens	10-15
15684417-8	2005	Moreover, TRAIL-induced RA FLS proliferation was inhibited by the protein kinase inhibitors PD98059, SB203580, and LY294002, confirming the involvement of the ERK, p38, and PI3 kinase/Akt signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	mitogen-activated protein kinase 14	Homo sapiens	164-167
15684417-8	2005	Moreover, TRAIL-induced RA FLS proliferation was inhibited by the protein kinase inhibitors PD98059, SB203580, and LY294002, confirming the involvement of the ERK, p38, and PI3 kinase/Akt signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	AKT serine/threonine kinase 1	Homo sapiens	184-187
15845920-2	2005	The results showed that insulin and IGF-I increased protein synthesis by 62% and 35% respectively in DPBS, and the effect was not affected by rapamycin, but was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	insulin	Homo sapiens	24-31
15845920-2	2005	The results showed that insulin and IGF-I increased protein synthesis by 62% and 35% respectively in DPBS, and the effect was not affected by rapamycin, but was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	insulin like growth factor 1	Homo sapiens	36-41
15845920-4	2005	Both LY294002 and rapamycin blocked the insulin and IGF-I-induced increases in 4EBP1 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	insulin	Homo sapiens	40-47
15845920-4	2005	Both LY294002 and rapamycin blocked the insulin and IGF-I-induced increases in 4EBP1 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	insulin like growth factor 1	Homo sapiens	52-57
15845920-4	2005	Both LY294002 and rapamycin blocked the insulin and IGF-I-induced increases in 4EBP1 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	79-84
15626746-6	2005	BCR/ABL-dependent expression of MCL-1 in Ba/F3 cells was counteracted by the mitogen-activated protein-kinase/extracellular signal-regulated kinase (MEK) inhibitor, PD98059, but not by the phosphoinositide 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	226-234	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	32-37
15833867-8	2005	Enforced expression of active Akt in tumor cells suppressed the combined effects of LY294002 or UCN-01, whereas dominant-negative Akt expression was sufficient to increase the sensitivity of tumor cells to rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Homo sapiens	30-33
15696579-6	2005	Activation was blocked completely by rapamycin and LY294002, thus demonstrating that OPN-1-stimulated migration occurs through mTOR and PI3K pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	oligophrenin 1	Homo sapiens	85-90
15696579-6	2005	Activation was blocked completely by rapamycin and LY294002, thus demonstrating that OPN-1-stimulated migration occurs through mTOR and PI3K pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	mechanistic target of rapamycin kinase	Homo sapiens	127-131
15834331-16	2005	Finally, inhibition of PI3K/Akt and MEK/ERK pathway using the inhibitors LY294002 and PD98059, respectively, impaired cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
15837766-5	2005	We used LY294002 to block PI3"-kinase/AKT activation and assess apoptosis by flow cytometric analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	AKT serine/threonine kinase 1	Homo sapiens	38-41
15837766-9	2005	FKHR and GSK3 were also constitutively phosphorylated in PELs and treatment with LY294002 caused their dephosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	forkhead box O1	Homo sapiens	0-4
15837766-10	2005	Although inhibition of PI3"-kinase induced cleavage of BID in all cell lines, cytochrome c was released from the mitochondria and caspase-9 and caspase-3 were activated in LY294002-induced apoptotic BC1 but not in resistant BCP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	BH3 interacting domain death agonist	Homo sapiens	55-58
15837766-10	2005	Although inhibition of PI3"-kinase induced cleavage of BID in all cell lines, cytochrome c was released from the mitochondria and caspase-9 and caspase-3 were activated in LY294002-induced apoptotic BC1 but not in resistant BCP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	cytochrome c, somatic	Homo sapiens	78-90
15837766-10	2005	Although inhibition of PI3"-kinase induced cleavage of BID in all cell lines, cytochrome c was released from the mitochondria and caspase-9 and caspase-3 were activated in LY294002-induced apoptotic BC1 but not in resistant BCP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	caspase 9	Homo sapiens	130-139
15837766-10	2005	Although inhibition of PI3"-kinase induced cleavage of BID in all cell lines, cytochrome c was released from the mitochondria and caspase-9 and caspase-3 were activated in LY294002-induced apoptotic BC1 but not in resistant BCP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	caspase 3	Homo sapiens	144-153
15837766-11	2005	Similarly, XIAP, a target of AKT, was down-regulated after LY294002 treatment only in sensitive PEL cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	X-linked inhibitor of apoptosis	Homo sapiens	11-15
15837766-11	2005	Similarly, XIAP, a target of AKT, was down-regulated after LY294002 treatment only in sensitive PEL cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	29-32
15834331-16	2005	Finally, inhibition of PI3K/Akt and MEK/ERK pathway using the inhibitors LY294002 and PD98059, respectively, impaired cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	Eph receptor B1	Rattus norvegicus	40-43
15668227-9	2005	Furthermore, TNFalpha-mediated astrocyte proliferation and GFAP expression was also inhibited by LY294002, a phosphatidylinositol 3-kinase inhibitor, which was reversed by exogenous LacCer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	tumor necrosis factor	Rattus norvegicus	13-21
15657050-7	2005	The activation of Rac was blocked by the PI3K inhibitors LY294002 and wortmannin and by transfection of a kinase-negative mutant of PI3K or a dominant-negative form of Vav2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	18-21
15668227-9	2005	Furthermore, TNFalpha-mediated astrocyte proliferation and GFAP expression was also inhibited by LY294002, a phosphatidylinositol 3-kinase inhibitor, which was reversed by exogenous LacCer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	glial fibrillary acidic protein	Rattus norvegicus	59-63
15657054-0	2005	Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-5
15657054-9	2005	Although the phosphatidylinositol 3-kinase inhibitor LY294002 also inhibits Pim-1, the structure of the LY294002.Pim-1 complex reveals a new binding mode that may be general for Ser/Thr kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	76-81
15677443-5	2005	Platelet-derived growth factor (PDGF) stimulated p70S6K phosphorylation, which was blocked by LY294002, an inhibitor of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	ribosomal protein S6 kinase B1	Homo sapiens	49-55
15657054-9	2005	Although the phosphatidylinositol 3-kinase inhibitor LY294002 also inhibits Pim-1, the structure of the LY294002.Pim-1 complex reveals a new binding mode that may be general for Ser/Thr kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	113-118
15668227-10	2005	LY294002 also inhibited TNFalpha-induced GalT-2 activation and LacCer synthesis, suggesting a phosphatidylinositol 3-kinase-mediated regulation of GalT-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Rattus norvegicus	24-32
15657054-9	2005	Although the phosphatidylinositol 3-kinase inhibitor LY294002 also inhibits Pim-1, the structure of the LY294002.Pim-1 complex reveals a new binding mode that may be general for Ser/Thr kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	113-118
15668227-10	2005	LY294002 also inhibited TNFalpha-induced GalT-2 activation and LacCer synthesis, suggesting a phosphatidylinositol 3-kinase-mediated regulation of GalT-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Beta-1,3-galactosyltransferase 4	Rattus norvegicus	41-47
15668227-10	2005	LY294002 also inhibited TNFalpha-induced GalT-2 activation and LacCer synthesis, suggesting a phosphatidylinositol 3-kinase-mediated regulation of GalT-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Beta-1,3-galactosyltransferase 4	Rattus norvegicus	147-153
15793288-6	2005	CK19 expression and branching morphogenesis were inhibited by dexamethasone, a mitogen-activated protein kinase kinase 1 (MEK1) inhibitor (PD98059), and a phosphatidyl inositol 3-kinase inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	keratin 19	Rattus norvegicus	0-4
15591103-3	2005	The PI3K inhibitors wortmannin and LY-294002 also attenuated strain-induced EC proliferation and strain-induced activation of S6K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-44	ribosomal protein S6 kinase B1	Bos taurus	126-129
15601625-3	2005	Biochemically, both LY294002 and Deltap85 decreased levels of p107 and cyclins D2, D3 and E and reduced retinoblastoma protein (pRb) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	RB transcriptional corepressor like 1	Mus musculus	62-126
15572521-6	2005	Inhibition of phosphatidylinositol 3-kinase (responsible for Akt activation) either by wortmanin or LY-294002 prevented Li(+)- or BIO-induced Akt phosphorylation and reduces cell survival without altering the phosphorylation state of GSK3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-109	thymoma viral proto-oncogene 1	Mus musculus	61-64
15572521-6	2005	Inhibition of phosphatidylinositol 3-kinase (responsible for Akt activation) either by wortmanin or LY-294002 prevented Li(+)- or BIO-induced Akt phosphorylation and reduces cell survival without altering the phosphorylation state of GSK3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-109	thymoma viral proto-oncogene 1	Mus musculus	142-145
15572521-6	2005	Inhibition of phosphatidylinositol 3-kinase (responsible for Akt activation) either by wortmanin or LY-294002 prevented Li(+)- or BIO-induced Akt phosphorylation and reduces cell survival without altering the phosphorylation state of GSK3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-109	glycogen synthase kinase 3 beta	Mus musculus	234-242
15601625-3	2005	Biochemically, both LY294002 and Deltap85 decreased levels of p107 and cyclins D2, D3 and E and reduced retinoblastoma protein (pRb) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	RB transcriptional corepressor 1	Mus musculus	128-131
15601625-4	2005	Significantly, only LY294002 treatment increased expression of p27(Kip1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	cyclin-dependent kinase inhibitor 1B	Mus musculus	63-66
15943954-0	2005	Elevated expression of NF-kappaB and Bcl-2 proteins in C2C12 myocytes during myogenesis is affected by PD98059, LY294002 and SB203580.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	23-32
15601625-4	2005	Significantly, only LY294002 treatment increased expression of p27(Kip1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	cyclin-dependent kinase inhibitor 1B	Mus musculus	67-71
15943954-0	2005	Elevated expression of NF-kappaB and Bcl-2 proteins in C2C12 myocytes during myogenesis is affected by PD98059, LY294002 and SB203580.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	B cell leukemia/lymphoma 2	Mus musculus	37-42
15601625-5	2005	Interestingly, LY294002 decreased IL-3-induced proliferation of primary bone marrow-derived mast cells (BMMC) derived from both wild-type and p27(Kip1)-deficient mice and importantly, LY294002 treatment failed to upregulate p27(Kip1) in wild-type BMMC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 3	Mus musculus	34-38
15601625-5	2005	Interestingly, LY294002 decreased IL-3-induced proliferation of primary bone marrow-derived mast cells (BMMC) derived from both wild-type and p27(Kip1)-deficient mice and importantly, LY294002 treatment failed to upregulate p27(Kip1) in wild-type BMMC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cyclin-dependent kinase inhibitor 1B	Mus musculus	142-145
15943954-6	2005	In contrast, decreased cytoplasmic levels but elevated nuclear expressions of myogenin were observed in myotubes treated with PD98059 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	myogenin	Mus musculus	78-86
15601625-5	2005	Interestingly, LY294002 decreased IL-3-induced proliferation of primary bone marrow-derived mast cells (BMMC) derived from both wild-type and p27(Kip1)-deficient mice and importantly, LY294002 treatment failed to upregulate p27(Kip1) in wild-type BMMC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cyclin-dependent kinase inhibitor 1B	Mus musculus	146-150
15601625-5	2005	Interestingly, LY294002 decreased IL-3-induced proliferation of primary bone marrow-derived mast cells (BMMC) derived from both wild-type and p27(Kip1)-deficient mice and importantly, LY294002 treatment failed to upregulate p27(Kip1) in wild-type BMMC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	interleukin 3	Mus musculus	34-38
15798216-11	2005	The inhibition of phosphatidylinositol 3-kinase (PI3K)-AKT signal transduction by Ly294002 and wortmannin significantly blocked c-Jun-regulated morphological transformation, while inhibition of basal MEK-ERK activity with PD98059 and U0126 had little effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	Eph receptor B1	Rattus norvegicus	204-207
15703783-2	2005	We show that the PI3-kinase/Akt pathway is constitutively active in primary acute myeloid leukaemia (AML) cells and that blockade by the selective inhibitor LY294002 reduces survival of the total blast population (mean 52%).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	AKT serine/threonine kinase 1	Homo sapiens	28-31
15668231-3	2005	Phosphatidylinositol 3-kinase inhibitor, LY294002, significantly decreased versican-luciferase (Luc) promoter activity and endogenous mRNA levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	versican	Homo sapiens	75-83
15778383-4	2005	Phagocytosis by CD14-positive THP-1 cells was attenuated by phosphatidylinositol-3 inhibitors LY294002 and wortmannin and experiments using transfected CHO cells showed substantial accumulation of phosphatidylinositol-3,4,5-trisphosphate at the BCG attachment site in CHO cells expressing CD14 and TLR2 suggesting that bacteria bind to CD14 and use TLR2 to initiate a PI3K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	CD14 molecule	Homo sapiens	16-20
15604116-11	2005	Treatment with LY294002 in the presence of PKCzeta-ODNs results in little further inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	protein kinase C zeta	Homo sapiens	43-50
15613482-5	2005	Our results show that these responses are associated with prolonged Akt phosphorylation relative to time-matched controls and are dependent on phosphatidylinositol 3-kinase (PI 3-kinase) and Smad2/3 signaling, based on the ability of the PI 3-kinase inhibitor LY294002 or infection with adenoviral dominant negative Smad3 (DN-Smad3) mutant to attenuate induction of cyclin D2, inhibin-alpha, aromatase, SCC, SF-1, and epiregulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	260-268	SMAD family member 2	Rattus norvegicus	191-198
15792809-4	2005	The induction of M-CSF was blocked by a phosphatidylinositol 3 kinase (PI3-kinase) inhibitor (LY294002), a Src family tyrosine kinase inhibitor (PP1) and an Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	colony stimulating factor 1 (macrophage)	Mus musculus	17-22
15792809-5	2005	Electrophoretic mobility shift assays showed that Abeta enhanced NF-kappaB binding activity to the NF-kappaB site of the mouse M-CSF promoter, which was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	histocompatibility 2, class II antigen A, beta 1	Mus musculus	50-55
15792809-5	2005	Electrophoretic mobility shift assays showed that Abeta enhanced NF-kappaB binding activity to the NF-kappaB site of the mouse M-CSF promoter, which was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	65-74
15792809-5	2005	Electrophoretic mobility shift assays showed that Abeta enhanced NF-kappaB binding activity to the NF-kappaB site of the mouse M-CSF promoter, which was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
15792809-5	2005	Electrophoretic mobility shift assays showed that Abeta enhanced NF-kappaB binding activity to the NF-kappaB site of the mouse M-CSF promoter, which was blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	164-172	colony stimulating factor 1 (macrophage)	Mus musculus	127-132
15637050-7	2005	A subset of these SFK-dependent genes was induced by PDGF even in the presence of the MEK1/2 inhibitor U0126 or the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	Rous sarcoma oncogene	Mus musculus	18-21
15780848-9	2005	Inhibition of kinases upstream to MEK1/2 (PI-3K, PKC, and CaMKII) by administration of LY294002, bisindolylmaleimide, or KN-62, respectively, also reversed clozapine-induced suppression of CAR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	mitogen activated protein kinase kinase 1	Rattus norvegicus	34-40
15780848-9	2005	Inhibition of kinases upstream to MEK1/2 (PI-3K, PKC, and CaMKII) by administration of LY294002, bisindolylmaleimide, or KN-62, respectively, also reversed clozapine-induced suppression of CAR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	42-64
15780848-9	2005	Inhibition of kinases upstream to MEK1/2 (PI-3K, PKC, and CaMKII) by administration of LY294002, bisindolylmaleimide, or KN-62, respectively, also reversed clozapine-induced suppression of CAR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	189-192
15632127-5	2005	In addition, IGF-I activated Akt while inhibiting caspase-3 activation, and these effects were reversed by the PI3K inhibitors LY 294002 and wortmannin, but not by the MEK1 inhibitor PD 98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-136	insulin like growth factor 1	Homo sapiens	13-18
15632127-5	2005	In addition, IGF-I activated Akt while inhibiting caspase-3 activation, and these effects were reversed by the PI3K inhibitors LY 294002 and wortmannin, but not by the MEK1 inhibitor PD 98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-136	AKT serine/threonine kinase 1	Homo sapiens	29-32
15632127-5	2005	In addition, IGF-I activated Akt while inhibiting caspase-3 activation, and these effects were reversed by the PI3K inhibitors LY 294002 and wortmannin, but not by the MEK1 inhibitor PD 98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-136	caspase 3	Homo sapiens	50-59
15659569-4	2005	LY294002, a chemical inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase), blocked completely the increasing effect of BPA on TG accumulation and expression of LPL and aP2 mRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	lipoprotein lipase	Mus musculus	164-167
15659569-4	2005	LY294002, a chemical inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase), blocked completely the increasing effect of BPA on TG accumulation and expression of LPL and aP2 mRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	fatty acid binding protein 4, adipocyte	Mus musculus	172-175
15642728-7	2005	Treatment of cells with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 or specific depletion of AKT expression by RNA interference can block both nicotine-induced Bax phosphorylation and cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	BCL2 associated X, apoptosis regulator	Homo sapiens	176-179
15752900-3	2005	To test the hypothesis that inhibition of PKB is responsible for the LY294002-induced apoptosis, LNCaP cells expressing a constitutively active form of PKB were generated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	protein tyrosine kinase 2 beta	Homo sapiens	42-45
15752900-4	2005	RESULTS: Treatment of LNCaP cells with the PI3K inhibitor, LY294002, caused inactivation of PKB, growth arrest, and apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	protein tyrosine kinase 2 beta	Homo sapiens	92-95
15752900-7	2005	Cells expressing constitutively active PKB were protected from apoptosis induced by LY294002, but not from the G1 growth arrest induced by PI3K inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	protein tyrosine kinase 2 beta	Homo sapiens	39-42
15683846-4	2005	Intratracheal administration of LY294002 significantly inhibited OVA-induced increases in total cell counts, eosinophil counts, and IL-5, IL-13, and eotaxin levels in bronchoalveolar lavage fluid.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	interleukin 5	Mus musculus	132-136
15744074-7	2005	Moreover, the GPIGS-stimulated HBK growth was inhibited by the treatment with LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI-3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	104-133
15572520-8	2005	Preincubation with LY-294002, a PI 3-kinase inhibitor, or expression of dominant-negative Akt prevented ANG II-stimulated increase in VEGF translation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	angiogenin	Homo sapiens	104-107
15572520-8	2005	Preincubation with LY-294002, a PI 3-kinase inhibitor, or expression of dominant-negative Akt prevented ANG II-stimulated increase in VEGF translation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	vascular endothelial growth factor A	Homo sapiens	134-138
15778701-7	2005	In T-lymphoblasts, LY294002, a PI3K inhibitor, prevents the induction of both D-type cyclin mRNA and protein, while rapamycin inhibits the induction of protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	proliferating cell nuclear antigen	Homo sapiens	85-91
15683846-4	2005	Intratracheal administration of LY294002 significantly inhibited OVA-induced increases in total cell counts, eosinophil counts, and IL-5, IL-13, and eotaxin levels in bronchoalveolar lavage fluid.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	interleukin 13	Mus musculus	138-143
15683846-4	2005	Intratracheal administration of LY294002 significantly inhibited OVA-induced increases in total cell counts, eosinophil counts, and IL-5, IL-13, and eotaxin levels in bronchoalveolar lavage fluid.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	chemokine (C-C motif) ligand 11	Mus musculus	149-156
15683846-7	2005	Western blot analysis of whole lung lysates shows that LY294002 markedly attenuated OVA-induced serine phosphorylation of Akt, a direct downstream substrate of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	thymoma viral proto-oncogene 1	Mus musculus	122-125
15728510-8	2005	Furthermore, the inhibition of STAT1-Ser(727) phosphorylation by Ly294002 did not affect STAT1 translocation, suggesting that STAT1 was not involved in sIL-1Ra gene induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	signal transducer and activator of transcription 1	Homo sapiens	31-36
15728533-7	2005	Both IL-4 and IL-13 induced the phosphorylation of Akt and increased the kinase activity of this enzyme in a manner that was sensitive to the phosphatidylinositol 3-kinase inhibitors LY294002 or wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	interleukin 4	Homo sapiens	5-9
15728533-7	2005	Both IL-4 and IL-13 induced the phosphorylation of Akt and increased the kinase activity of this enzyme in a manner that was sensitive to the phosphatidylinositol 3-kinase inhibitors LY294002 or wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	interleukin 13	Homo sapiens	14-19
15728533-7	2005	Both IL-4 and IL-13 induced the phosphorylation of Akt and increased the kinase activity of this enzyme in a manner that was sensitive to the phosphatidylinositol 3-kinase inhibitors LY294002 or wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	AKT serine/threonine kinase 1	Homo sapiens	51-54
15706421-6	2005	The combination of FK228 and a phosphatidylinositol 3-kinase (PI3K)/Akt pathway inhibitor, LY294002, was determined to be synergistically cytotoxic in PC14 cells by isobologram analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	31-60
15714459-5	2005	Furthermore, LY294002 inhibited phosphorylation of p70 S6 kinase and 4E-BP1, suggesting that the phosphorylation of p70 S6 kinase and 4E-BP1 in HL cells is PI3-kinase dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	69-75
15714459-5	2005	Furthermore, LY294002 inhibited phosphorylation of p70 S6 kinase and 4E-BP1, suggesting that the phosphorylation of p70 S6 kinase and 4E-BP1 in HL cells is PI3-kinase dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	134-140
15714461-3	2005	The data show that HIF-1alpha expression is induced by bFGF in a dose- and time-dependent fashion, while increased HIF-1alpha protein expression and transactivity of HIF-1 are due to the phosphorylation of Akt by bFGF, as indicated by application of the phosphatidylinositol 3-kinase (PI-3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	302-310	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
15714461-3	2005	The data show that HIF-1alpha expression is induced by bFGF in a dose- and time-dependent fashion, while increased HIF-1alpha protein expression and transactivity of HIF-1 are due to the phosphorylation of Akt by bFGF, as indicated by application of the phosphatidylinositol 3-kinase (PI-3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	302-310	AKT serine/threonine kinase 1	Homo sapiens	206-209
15714461-7	2005	Treatment of the cells with bFGF increased the amount of VEGF release, and this could be suppressed by either PD98059 or LY294002, suggesting the presence of a HIF-1alpha-dependent pathway for bFGF-induced VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	fibroblast growth factor 2	Homo sapiens	28-32
15714461-7	2005	Treatment of the cells with bFGF increased the amount of VEGF release, and this could be suppressed by either PD98059 or LY294002, suggesting the presence of a HIF-1alpha-dependent pathway for bFGF-induced VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	vascular endothelial growth factor A	Homo sapiens	57-61
15714461-7	2005	Treatment of the cells with bFGF increased the amount of VEGF release, and this could be suppressed by either PD98059 or LY294002, suggesting the presence of a HIF-1alpha-dependent pathway for bFGF-induced VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	hypoxia inducible factor 1 subunit alpha	Homo sapiens	160-170
15714461-7	2005	Treatment of the cells with bFGF increased the amount of VEGF release, and this could be suppressed by either PD98059 or LY294002, suggesting the presence of a HIF-1alpha-dependent pathway for bFGF-induced VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	fibroblast growth factor 2	Homo sapiens	193-197
15714461-7	2005	Treatment of the cells with bFGF increased the amount of VEGF release, and this could be suppressed by either PD98059 or LY294002, suggesting the presence of a HIF-1alpha-dependent pathway for bFGF-induced VEGF production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	vascular endothelial growth factor A	Homo sapiens	206-210
15607817-8	2005	Furthermore, U0126 and LY294002, which respectively inhibit MEK-induced ERK phosphorylation and PI3 kinase-mediated Akt phosphorylation had distinct effects on C3a-induced responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	mitogen-activated protein kinase kinase 7	Homo sapiens	60-63
15881653-6	2005	Also, treatment of PC12 cells with the PI3-K inhibitor LY294002 reduced ERK activation by NGF; thus, higher NGF concentrations were required to initiate chemotaxis and to achieve the same maximal chemotactic response seen in untreated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	Eph receptor B1	Rattus norvegicus	72-75
15881653-6	2005	Also, treatment of PC12 cells with the PI3-K inhibitor LY294002 reduced ERK activation by NGF; thus, higher NGF concentrations were required to initiate chemotaxis and to achieve the same maximal chemotactic response seen in untreated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	nerve growth factor	Rattus norvegicus	90-93
15881653-6	2005	Also, treatment of PC12 cells with the PI3-K inhibitor LY294002 reduced ERK activation by NGF; thus, higher NGF concentrations were required to initiate chemotaxis and to achieve the same maximal chemotactic response seen in untreated PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	nerve growth factor	Rattus norvegicus	108-111
15881653-8	2005	In comparison, LY294002 treatment had no effect on ERK activation by EGF, but the chemotactic response was reduced at all the concentrations of EGF tested indicating that NGF and EGF differed in the utilization of ERK and PI3-K to signal chemotaxis in PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	nerve growth factor	Rattus norvegicus	171-174
15881653-8	2005	In comparison, LY294002 treatment had no effect on ERK activation by EGF, but the chemotactic response was reduced at all the concentrations of EGF tested indicating that NGF and EGF differed in the utilization of ERK and PI3-K to signal chemotaxis in PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	Eph receptor B1	Rattus norvegicus	214-217
15715661-5	2005	Treatment with different inhibitors including rapamycin, wortmannin, LY294002, and U0126, and their combinations, indicated that phosphorylation of p70S6K and GSK-3beta is regulated by rapamycin-dependent, PI3K and MAPK pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	ribosomal protein S6 kinase B1	Homo sapiens	148-154
15715661-5	2005	Treatment with different inhibitors including rapamycin, wortmannin, LY294002, and U0126, and their combinations, indicated that phosphorylation of p70S6K and GSK-3beta is regulated by rapamycin-dependent, PI3K and MAPK pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	glycogen synthase kinase 3 beta	Homo sapiens	159-168
15715661-5	2005	Treatment with different inhibitors including rapamycin, wortmannin, LY294002, and U0126, and their combinations, indicated that phosphorylation of p70S6K and GSK-3beta is regulated by rapamycin-dependent, PI3K and MAPK pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	mitogen-activated protein kinase 3	Homo sapiens	215-219
15857748-4	2005	Transactivation of estrogen-sensitive genes by FSH or PKA activators were blocked (approximately 90%) by H89 (PKA inhibitor) and LY294002 but not by Wortmannin (PI3-K inhibitors), 4-OH-tamoxifen, ICI182,780 or SB203580 (p38 MAPK inhibitor); PD98059 (ERK1/2 inhibitor) partially (approximately 30%) blocked the FSH-mediated effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	mitogen-activated protein kinase 1	Homo sapiens	220-223
15857748-4	2005	Transactivation of estrogen-sensitive genes by FSH or PKA activators were blocked (approximately 90%) by H89 (PKA inhibitor) and LY294002 but not by Wortmannin (PI3-K inhibitors), 4-OH-tamoxifen, ICI182,780 or SB203580 (p38 MAPK inhibitor); PD98059 (ERK1/2 inhibitor) partially (approximately 30%) blocked the FSH-mediated effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	mitogen-activated protein kinase 3	Homo sapiens	250-256
15607817-8	2005	Furthermore, U0126 and LY294002, which respectively inhibit MEK-induced ERK phosphorylation and PI3 kinase-mediated Akt phosphorylation had distinct effects on C3a-induced responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	mitogen-activated protein kinase 1	Homo sapiens	72-75
15607817-8	2005	Furthermore, U0126 and LY294002, which respectively inhibit MEK-induced ERK phosphorylation and PI3 kinase-mediated Akt phosphorylation had distinct effects on C3a-induced responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	complement C3	Homo sapiens	160-163
15607817-10	2005	In contrast, LY294002 had no effect on C3a-induced RANTES/CCL5 production but blocked MCP-1/CCL2 generation by 83.7+/-1.5%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	C-C motif chemokine ligand 2	Homo sapiens	86-91
15607817-10	2005	In contrast, LY294002 had no effect on C3a-induced RANTES/CCL5 production but blocked MCP-1/CCL2 generation by 83.7+/-1.5%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	C-C motif chemokine ligand 2	Homo sapiens	92-96
16018579-2	2005	LY294002 induced increased propidium iodide (PI) uptake and caspase 3/7 activity in both regions, with a faster onset in DG.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Homo sapiens	60-69
15706421-6	2005	The combination of FK228 and a phosphatidylinositol 3-kinase (PI3K)/Akt pathway inhibitor, LY294002, was determined to be synergistically cytotoxic in PC14 cells by isobologram analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	AKT serine/threonine kinase 1	Homo sapiens	68-71
15572370-5	2005	These S100B-induced effects, as well as the reduced ability of S100B+ PC12 cells to respond to NGF, were dependent on Akt activation because they were remarkably reduced or abrogated in the presence of LY294002, an inhibitor of the Akt upstream kinase phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	S100 calcium binding protein B	Rattus norvegicus	6-11
15664394-8	2005	Inhibition of phosphoinositide 3-kinase by LY294002, however, significantly reduced both TNF- and PDGF-stimulated chemotaxis (by 38-54%, P&lt;0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	tumor necrosis factor	Oryctolagus cuniculus	89-92
15664394-9	2005	In contrast, both U0126 and LY294002 abolished SMC [(3)H]thymidine incorporation induced by either TNF, PDGF, or both agonists.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	tumor necrosis factor	Oryctolagus cuniculus	99-102
15735031-7	2005	Immunofluorescent staining showed an EGF-induced, LY294002-sensitive translocation of PKCzeta from the cytosol to the plasma membrane, indicating that EGF was capable of activating PKCzeta, probably via phosphoinositide 3 kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	epidermal growth factor	Homo sapiens	37-40
15735031-7	2005	Immunofluorescent staining showed an EGF-induced, LY294002-sensitive translocation of PKCzeta from the cytosol to the plasma membrane, indicating that EGF was capable of activating PKCzeta, probably via phosphoinositide 3 kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	protein kinase C zeta	Homo sapiens	86-93
15735031-7	2005	Immunofluorescent staining showed an EGF-induced, LY294002-sensitive translocation of PKCzeta from the cytosol to the plasma membrane, indicating that EGF was capable of activating PKCzeta, probably via phosphoinositide 3 kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	epidermal growth factor	Homo sapiens	151-154
15735031-7	2005	Immunofluorescent staining showed an EGF-induced, LY294002-sensitive translocation of PKCzeta from the cytosol to the plasma membrane, indicating that EGF was capable of activating PKCzeta, probably via phosphoinositide 3 kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	protein kinase C zeta	Homo sapiens	181-188
15574430-7	2005	Investigation into possible signal transduction pathways mediating IL-18 effects revealed that IL-18 activates phosphoinositide 3-kinase (PI3K), an effect that was blocked by wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-199	interleukin 18	Homo sapiens	67-72
15685229-5	2005	Inhibition studies with LY294002 demonstrated that the serum signal is mediated via the phosphoinositide 3-OH kinase/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	117-120
15652490-3	2005	The effect of Ang II on FAK and paxillin phosphorylation was markedly attenuated in cells pretreated with wortmannin and LY294002, indicating that phosphoinositide 3-kinase (PI3K) plays an important role in regulating FAK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	angiogenin	Homo sapiens	14-17
15652490-3	2005	The effect of Ang II on FAK and paxillin phosphorylation was markedly attenuated in cells pretreated with wortmannin and LY294002, indicating that phosphoinositide 3-kinase (PI3K) plays an important role in regulating FAK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	protein tyrosine kinase 2	Homo sapiens	24-27
15652490-3	2005	The effect of Ang II on FAK and paxillin phosphorylation was markedly attenuated in cells pretreated with wortmannin and LY294002, indicating that phosphoinositide 3-kinase (PI3K) plays an important role in regulating FAK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	protein tyrosine kinase 2	Homo sapiens	218-221
15574430-7	2005	Investigation into possible signal transduction pathways mediating IL-18 effects revealed that IL-18 activates phosphoinositide 3-kinase (PI3K), an effect that was blocked by wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-199	interleukin 18	Homo sapiens	95-100
15572370-5	2005	These S100B-induced effects, as well as the reduced ability of S100B+ PC12 cells to respond to NGF, were dependent on Akt activation because they were remarkably reduced or abrogated in the presence of LY294002, an inhibitor of the Akt upstream kinase phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	S100 calcium binding protein B	Rattus norvegicus	63-68
15572370-5	2005	These S100B-induced effects, as well as the reduced ability of S100B+ PC12 cells to respond to NGF, were dependent on Akt activation because they were remarkably reduced or abrogated in the presence of LY294002, an inhibitor of the Akt upstream kinase phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	nerve growth factor	Rattus norvegicus	95-98
15572370-5	2005	These S100B-induced effects, as well as the reduced ability of S100B+ PC12 cells to respond to NGF, were dependent on Akt activation because they were remarkably reduced or abrogated in the presence of LY294002, an inhibitor of the Akt upstream kinase phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
15572370-5	2005	These S100B-induced effects, as well as the reduced ability of S100B+ PC12 cells to respond to NGF, were dependent on Akt activation because they were remarkably reduced or abrogated in the presence of LY294002, an inhibitor of the Akt upstream kinase phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	AKT serine/threonine kinase 1	Rattus norvegicus	232-235
15358610-6	2005	Inhibiting the IPC-induced phosphorylation of Akt, ERK-1/2, and p70S6K at reperfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002 or the MEK-1/2 inhibitor PD-98059 abrogated IPC-induced protection (46.3 +/- 5.8, 49.2 +/- 4.0, and 20.9 +/- 3.6% for IPC + LY-294002, IPC + PD-98059, and IPC, respectively, P &lt; 0.01), demonstrating that the phosphorylation of these kinases at reperfusion is required for IPC-induced protection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-151	AKT serine/threonine kinase 1	Rattus norvegicus	46-49
15558015-10	2005	Two different PI-3K inhibitors, wortmannin and LY294002, showed Akt-independent activation of NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	AKT serine/threonine kinase 1	Homo sapiens	64-67
15558015-10	2005	Two different PI-3K inhibitors, wortmannin and LY294002, showed Akt-independent activation of NF-kappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	nuclear factor kappa B subunit 1	Homo sapiens	94-103
15592522-4	2005	REDD1 expression is markedly reduced in PC-3 cells treated with LY294002 (LY) or Rapamycin and strongly induced under hypoxic conditions in a hypoxia-inducible factor-1 (HIF-1)-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	DNA damage inducible transcript 4	Homo sapiens	0-5
15592522-4	2005	REDD1 expression is markedly reduced in PC-3 cells treated with LY294002 (LY) or Rapamycin and strongly induced under hypoxic conditions in a hypoxia-inducible factor-1 (HIF-1)-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	170-175
15456694-9	2005	The specific PI3K inhibitor LY-294002 in the presence of TGF-beta1, IL-13, or the combination of the two caused significant increases in TIMP-1 mRNA expression, while LY-294002 increased TIMP-1 protein levels in the presence of IL-13 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-37	transforming growth factor beta 1	Homo sapiens	57-66
15456694-9	2005	The specific PI3K inhibitor LY-294002 in the presence of TGF-beta1, IL-13, or the combination of the two caused significant increases in TIMP-1 mRNA expression, while LY-294002 increased TIMP-1 protein levels in the presence of IL-13 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-37	interleukin 13	Homo sapiens	68-73
15456694-9	2005	The specific PI3K inhibitor LY-294002 in the presence of TGF-beta1, IL-13, or the combination of the two caused significant increases in TIMP-1 mRNA expression, while LY-294002 increased TIMP-1 protein levels in the presence of IL-13 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-37	TIMP metallopeptidase inhibitor 1	Homo sapiens	137-143
15358610-6	2005	Inhibiting the IPC-induced phosphorylation of Akt, ERK-1/2, and p70S6K at reperfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002 or the MEK-1/2 inhibitor PD-98059 abrogated IPC-induced protection (46.3 +/- 5.8, 49.2 +/- 4.0, and 20.9 +/- 3.6% for IPC + LY-294002, IPC + PD-98059, and IPC, respectively, P &lt; 0.01), demonstrating that the phosphorylation of these kinases at reperfusion is required for IPC-induced protection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-151	mitogen activated protein kinase 3	Rattus norvegicus	51-58
15456694-9	2005	The specific PI3K inhibitor LY-294002 in the presence of TGF-beta1, IL-13, or the combination of the two caused significant increases in TIMP-1 mRNA expression, while LY-294002 increased TIMP-1 protein levels in the presence of IL-13 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-37	TIMP metallopeptidase inhibitor 1	Homo sapiens	187-193
15469954-6	2005	A phosphoinositide 3-kinase inhibitor, LY-294002, blocked H. pylori LPS-induced Rac1 activation and O2- generation without interfering with the expression of Nox1 and NOXO1 mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	ras-related C3 botulinum toxin substrate 1	Cavia porcellus	80-84
15456694-9	2005	The specific PI3K inhibitor LY-294002 in the presence of TGF-beta1, IL-13, or the combination of the two caused significant increases in TIMP-1 mRNA expression, while LY-294002 increased TIMP-1 protein levels in the presence of IL-13 alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-37	interleukin 13	Homo sapiens	228-233
15358610-6	2005	Inhibiting the IPC-induced phosphorylation of Akt, ERK-1/2, and p70S6K at reperfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002 or the MEK-1/2 inhibitor PD-98059 abrogated IPC-induced protection (46.3 +/- 5.8, 49.2 +/- 4.0, and 20.9 +/- 3.6% for IPC + LY-294002, IPC + PD-98059, and IPC, respectively, P &lt; 0.01), demonstrating that the phosphorylation of these kinases at reperfusion is required for IPC-induced protection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-151	ribosomal protein S6 kinase B1	Rattus norvegicus	64-70
15358610-6	2005	Inhibiting the IPC-induced phosphorylation of Akt, ERK-1/2, and p70S6K at reperfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002 or the MEK-1/2 inhibitor PD-98059 abrogated IPC-induced protection (46.3 +/- 5.8, 49.2 +/- 4.0, and 20.9 +/- 3.6% for IPC + LY-294002, IPC + PD-98059, and IPC, respectively, P &lt; 0.01), demonstrating that the phosphorylation of these kinases at reperfusion is required for IPC-induced protection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-151	mitogen activated protein kinase kinase 1	Rattus norvegicus	159-166
15550506-6	2005	Cirazoline- or insulin-mediated glucose uptake was inhibited by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting a possible interaction between the alpha1-adrenoceptor and insulin pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	insulin	Homo sapiens	15-22
15733066-7	2005	Exposure of pre- and post-confluent cells to LY294002, a specific PI3-K inhibitor, for 1-4 days profoundly reduced TFF3 and MUC2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	trefoil factor 3	Homo sapiens	115-119
15733066-7	2005	Exposure of pre- and post-confluent cells to LY294002, a specific PI3-K inhibitor, for 1-4 days profoundly reduced TFF3 and MUC2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	124-128
15483224-6	2005	MAdCAM-1 expression was inhibited by both SN-50 (NF-kappaB inhibitor) and LY-294002 [phosphatidylinositol 3-kinase (PI3-K) inhibitor], whereas ICAM-1 and E-selectin expression was inhibited by SN-50 but not by LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-83	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	0-8
15483224-6	2005	MAdCAM-1 expression was inhibited by both SN-50 (NF-kappaB inhibitor) and LY-294002 [phosphatidylinositol 3-kinase (PI3-K) inhibitor], whereas ICAM-1 and E-selectin expression was inhibited by SN-50 but not by LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-83	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	85-114
15483224-6	2005	MAdCAM-1 expression was inhibited by both SN-50 (NF-kappaB inhibitor) and LY-294002 [phosphatidylinositol 3-kinase (PI3-K) inhibitor], whereas ICAM-1 and E-selectin expression was inhibited by SN-50 but not by LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-219	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	0-8
15550506-6	2005	Cirazoline- or insulin-mediated glucose uptake was inhibited by the phosphatidylinositol-3 kinase inhibitor LY294002, suggesting a possible interaction between the alpha1-adrenoceptor and insulin pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	insulin	Homo sapiens	188-195
15316930-4	2005	Selective pharmacological inhibitors of the PI3K/Akt axis (LY294002, wortmannin) were employed to influence the sensitivity to As2O3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	49-52
15501927-8	2005	The activation of p70S6K/S6 pathway was sensitive to inhibition by rapamycin and LY294002, indicating that mTOR and PI3K/Akt are upstream signaling regulators.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	ribosomal protein S6 kinase B1	Homo sapiens	18-24
15501927-8	2005	The activation of p70S6K/S6 pathway was sensitive to inhibition by rapamycin and LY294002, indicating that mTOR and PI3K/Akt are upstream signaling regulators.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	mechanistic target of rapamycin kinase	Homo sapiens	107-111
15501927-8	2005	The activation of p70S6K/S6 pathway was sensitive to inhibition by rapamycin and LY294002, indicating that mTOR and PI3K/Akt are upstream signaling regulators.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	121-124
15662223-6	2005	In the arteries from WKY rats, co-incubation with either wortmannin or LY294002, inhibitors of PI3-kinase, attenuated the effect of IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	insulin-like growth factor 1	Rattus norvegicus	132-137
15678124-6	2005	Indeed, the protective effect of OPN was reduced by inhibiting the activation of Akt and p42/p44 MAPK using LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	secreted phosphoprotein 1	Mus musculus	33-36
15678124-6	2005	Indeed, the protective effect of OPN was reduced by inhibiting the activation of Akt and p42/p44 MAPK using LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	thymoma viral proto-oncogene 1	Mus musculus	81-84
15678124-6	2005	Indeed, the protective effect of OPN was reduced by inhibiting the activation of Akt and p42/p44 MAPK using LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	cyclin-dependent kinase 20	Mus musculus	89-92
15678124-6	2005	Indeed, the protective effect of OPN was reduced by inhibiting the activation of Akt and p42/p44 MAPK using LY294002 and U0126, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	mitogen-activated protein kinase 3	Mus musculus	93-101
15735908-0	2005	PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	AKT serine/threonine kinase 1	Homo sapiens	0-7
15686478-4	2005	In contrast, the treatment with the phosphatidylinositol 3"-kinase (PI3K) inhibitor LY294002, but not with its inactive analogue LY303511, completely abolished the NGF-induced production of ACh.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	36-66
15735908-4	2005	The effects of LY294002, a biochemical inhibitor of PI3-kinase, on the response to radiation were examined in the PTEN mutant glioma cell line U251 MG. Low doses of LY294002 sensitized U251 MG to clinically relevant doses of radiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	phosphatase and tensin homolog	Homo sapiens	114-118
15735908-7	2005	Furthermore, using a myristoylated PKB/Akt construct, we identified PKB/Akt as the downstream molecule that mediates the synergistic cytotoxicity between LY294002 and radiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Homo sapiens	35-42
15735908-7	2005	Furthermore, using a myristoylated PKB/Akt construct, we identified PKB/Akt as the downstream molecule that mediates the synergistic cytotoxicity between LY294002 and radiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Homo sapiens	68-75
15713898-9	2005	The level of caspase-3 activation achieved under these conditions is equivalent to that observed with the phosphatidylinositol-3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	caspase 3	Homo sapiens	13-22
15537868-0	2005	Inhibition of L-type Cav1.2 Ca2+ channels by 2,(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Go6983).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	21-27
15755875-6	2005	Topical treatment with SB202190 (a specific inhibitor of p38 MAPK) or LY294002 (a specific inhibitor of PI3K) significantly decreased UVB-induced AP-1 activation by 84% and 68%, respectively, as well as COX-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	jun proto-oncogene	Mus musculus	146-150
15471943-7	2005	Furthermore, GLP-2 inhibited HeLa cell apoptosis induced by LY294002 in a protein kinase A-dependent, but ERK-independent, manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	glucagon	Homo sapiens	13-18
15342355-6	2005	This stimulatory effect of bicarbonate and LY294002 is mediated by an increase in cAMP production and tyrosine phosphorylation of the A kinase anchoring protein, AKAP3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	A-kinase anchoring protein 3	Homo sapiens	162-167
15734199-6	2005	Both BIBX1382BS as well as the PI3 kinase inhibitor LY294002 led to a blockage (for A549 cells) or reduction (for FaDu cells) of radiation-induced P-AKT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	149-152
15695173-5	2005	In the FGF1-treated explants, the number of terminal buds and BrdU-labelled cells increased significantly, while the LY294002-, wortmannin-, PD98059-treated explants demonstrated obvious decreases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	fibroblast growth factor 1	Mus musculus	7-11
15695173-6	2005	The effects by FGF1 were inhibited by LY294002, wortmannin and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	fibroblast growth factor 1	Mus musculus	15-19
15580293-9	2005	Myc stimulates VEGF production by a rapamycin- and LY294002-sensitive pathway, which does not involve alteration of eIF4E activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
15580293-9	2005	Myc stimulates VEGF production by a rapamycin- and LY294002-sensitive pathway, which does not involve alteration of eIF4E activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	vascular endothelial growth factor A	Homo sapiens	15-19
15816525-0	2005	Blockage of cyclin cdk"s, PKC and phosphoinositol 3-kinase pathways leads to augmentation of apoptosis in drug-resistant leukemia cells: evidence for interactive effects of flavopiridol, LY 294002, roscovitine,wortmannin and UCN-01.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-196	proliferating cell nuclear antigen	Mus musculus	12-18
15642134-12	2005	IL-17 production by activated RA PBMC is completely or partly blocked in the presence of the NF-kappaB inhibitor pyrrolidine dithiocarbamate and the PI3K/Akt inhibitor wortmannin and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	interleukin 17A	Homo sapiens	0-5
15665513-3	2005	Wortmannin, LY294002 and dominant negative Akt, as well as dominant negative NF-kappaB-inducing kinase (NIK) inhibited MUC2 reporter transcription, indicating that both phosphatidylinositol-3-OH kinase (PI3K)/Akt signaling pathway and NIK pathways mediate the effects of TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	119-123
15755875-6	2005	Topical treatment with SB202190 (a specific inhibitor of p38 MAPK) or LY294002 (a specific inhibitor of PI3K) significantly decreased UVB-induced AP-1 activation by 84% and 68%, respectively, as well as COX-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	prostaglandin-endoperoxide synthase 2	Mus musculus	203-208
15545271-5	2005	Blocking of phosphoinositide 3-OH kinase by selective inhibitors (LY-294002 and wortmannin) abrogated the stretch-induced PKB/Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-75	AKT serine/threonine kinase 1	Homo sapiens	122-125
15545271-5	2005	Blocking of phosphoinositide 3-OH kinase by selective inhibitors (LY-294002 and wortmannin) abrogated the stretch-induced PKB/Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-75	AKT serine/threonine kinase 1	Homo sapiens	126-129
15642371-6	2005	GSK3beta inhibition by indirubins circumvented the effect of hypoxia/anoxia or LY294002 on HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	glycogen synthase kinase 3 beta	Homo sapiens	0-8
15642371-6	2005	GSK3beta inhibition by indirubins circumvented the effect of hypoxia/anoxia or LY294002 on HIF-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	91-101
16083947-14	2005	In line with this, we found that in PB-T the PI3K-inhibitors wortmannin and LY294002 block activation induced cofilin dephosphorylation and its association with the actin cytoskeleton.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	cofilin 1	Homo sapiens	110-117
16083947-15	2005	In Jurkat cells, however, where cofilin is present mainly in its non-phosphorylated form and permanently associated with the actin cytoskeleton, wortmannin and LY294002 do not block these events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	cofilin 1	Homo sapiens	32-39
15345487-7	2005	Inhibition of phosphorylated Akt expression using the phosphatidylinositol 3-kinase inhibitor LY-294002 (16 microM) abrogated the increased expression of h-caldesmon and SM2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-103	AKT serine/threonine kinase 1	Rattus norvegicus	29-32
15345487-7	2005	Inhibition of phosphorylated Akt expression using the phosphatidylinositol 3-kinase inhibitor LY-294002 (16 microM) abrogated the increased expression of h-caldesmon and SM2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-103	caldesmon 1	Rattus norvegicus	154-165
15889536-7	2005	Because LY294002, an inhibitor of cellular phosphatidylinositol 3-kinase (PI3-K), also prohibited HCMV-mediated activation of Akt and NFkappaB and synthesis of the MIE proteins, PI3-K signalling was necessary for expressing the MIE genes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	AKT serine/threonine kinase 1	Homo sapiens	126-129
15889536-7	2005	Because LY294002, an inhibitor of cellular phosphatidylinositol 3-kinase (PI3-K), also prohibited HCMV-mediated activation of Akt and NFkappaB and synthesis of the MIE proteins, PI3-K signalling was necessary for expressing the MIE genes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	nuclear factor kappa B subunit 1	Homo sapiens	134-142
16168105-6	2005	We also treated several breast cancer cells with the PIK3CA inhibitor LY294002 and compared the apoptosis status in cells with and without PIK3CA mutation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	53-59
16168116-14	2005	Both the PI-3K inhibitor LY 294002 and MEK inhibitor PD 98059 significantly decreased the stimulatory effect of HRG on tumor cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-34	neuregulin 1	Mus musculus	112-115
15881420-8	2005	Addition of the PI3K inhibitor LY294002 decreased GJIC and Cx43 expression in astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	gap junction protein alpha 1	Homo sapiens	59-63
15947481-9	2005	Furthermore, ERK1/2 activation by WKYMVm was completely inhibited by pretreatment with the PI3-kinase inhibitor LY294002, but not by the PKC inhibitor Ro-31-8220.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	mitogen-activated protein kinase 3	Homo sapiens	13-19
16036314-12	2005	Phosphorylation of eNOS Ser1177 under shear stress was elevated by 20 min, a response that was blocked by PI-3K (phosphatidylinositol 3-kinase) inhibitors wortmannin and LY294002, but not the MEK (MAPK kinase) inhibitor UO126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	nitric oxide synthase 3	Homo sapiens	19-23
16036314-12	2005	Phosphorylation of eNOS Ser1177 under shear stress was elevated by 20 min, a response that was blocked by PI-3K (phosphatidylinositol 3-kinase) inhibitors wortmannin and LY294002, but not the MEK (MAPK kinase) inhibitor UO126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	113-142
16036314-12	2005	Phosphorylation of eNOS Ser1177 under shear stress was elevated by 20 min, a response that was blocked by PI-3K (phosphatidylinositol 3-kinase) inhibitors wortmannin and LY294002, but not the MEK (MAPK kinase) inhibitor UO126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	mitogen-activated protein kinase kinase 7	Homo sapiens	192-195
16036314-12	2005	Phosphorylation of eNOS Ser1177 under shear stress was elevated by 20 min, a response that was blocked by PI-3K (phosphatidylinositol 3-kinase) inhibitors wortmannin and LY294002, but not the MEK (MAPK kinase) inhibitor UO126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	mitogen-activated protein kinase 3	Homo sapiens	197-201
15968086-5	2005	The PI3K signaling pathway might be involved in this effect of NRG as the downstream effector of PI3K, protein kinase B (PKB/AkT), is activated by NRG in the presence of Abeta, and PKB/AkT activation is inhibited by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	236-244	protein tyrosine kinase 2 beta	Homo sapiens	103-119
15526284-11	2005	LY294002, a phosphatidylinositol 3 (PI3) kinase inhibitor, inhibited the association of eNOS/Akt and the phosphorylation of eNOS but had no effect on the interaction between eNOS and HSP90 during early hours of exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 3	Homo sapiens	88-92
15526284-11	2005	LY294002, a phosphatidylinositol 3 (PI3) kinase inhibitor, inhibited the association of eNOS/Akt and the phosphorylation of eNOS but had no effect on the interaction between eNOS and HSP90 during early hours of exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	93-96
15526284-11	2005	LY294002, a phosphatidylinositol 3 (PI3) kinase inhibitor, inhibited the association of eNOS/Akt and the phosphorylation of eNOS but had no effect on the interaction between eNOS and HSP90 during early hours of exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 3	Homo sapiens	124-128
15526284-11	2005	LY294002, a phosphatidylinositol 3 (PI3) kinase inhibitor, inhibited the association of eNOS/Akt and the phosphorylation of eNOS but had no effect on the interaction between eNOS and HSP90 during early hours of exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 3	Homo sapiens	124-128
15526284-11	2005	LY294002, a phosphatidylinositol 3 (PI3) kinase inhibitor, inhibited the association of eNOS/Akt and the phosphorylation of eNOS but had no effect on the interaction between eNOS and HSP90 during early hours of exposure.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heat shock protein 90 alpha family class A member 1	Homo sapiens	183-188
16372478-7	2005	Wortmannin and LY294002, phosphatidylinositol 3"-kinase inhibitors, decreased the Ang1-induced anti-apoptotic effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	angiopoietin 1	Homo sapiens	82-86
15389531-8	2005	Moreover, while the specific PI3 kinase inhibitor, LY294002, abolished this FN-mediated cell survival, the MAPK kinase inhibitor, PD98059, had no significant effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	fibronectin 1	Homo sapiens	76-78
16696310-5	2005	However, changes in LDH, MDA, AI and phosphorylated Akt resulting from insulin were attenuated or abolished by LY294002 (PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
15509657-4	2005	Weakening of cell-matrix adhesion is blocked significantly (p &lt; 0.01) by the catalytically inactive IGF-I receptor (IGF-IR) and the phosphoinositide 3-kinase (PI-3 kinase) inhibitor LY-294002, but it is unaffected by mitogen-activated protein kinase kinase inhibitor UO-126 and Src kinase inhibitor PP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-194	insulin like growth factor 1 receptor	Homo sapiens	103-117
15696050-11	2005	Wortmannin and LY294002 inhibited phosphorylation of the Thr 389 site of p70S6K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	ribosomal protein S6 kinase B1	Homo sapiens	73-79
15459249-7	2005	Caffeine, wortmannin, LY294002, and rapamycin-FKBP12 also markedly inhibited mTOR activity in vitro, but unlike FTS, none of the other mTOR inhibitors appreciably changed the amount of raptor associated with mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	mechanistic target of rapamycin kinase	Homo sapiens	77-81
15607953-6	2005	The phosphatidylinositol 3-kinase (PI 3-K) inhibitors LY294002 and wortmannin prevented phosphorylation of AKT in response to HU-210, and reversed the neuroprotective effect of HU-210 on S-AMPA-induced excitotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	4-33
15509657-4	2005	Weakening of cell-matrix adhesion is blocked significantly (p &lt; 0.01) by the catalytically inactive IGF-I receptor (IGF-IR) and the phosphoinositide 3-kinase (PI-3 kinase) inhibitor LY-294002, but it is unaffected by mitogen-activated protein kinase kinase inhibitor UO-126 and Src kinase inhibitor PP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-194	insulin like growth factor 1 receptor	Homo sapiens	119-125
15567516-8	2005	The neuroprotective effects of BDNF were suppressed by pretreatment with LY 294002 (a PI 3-kinase inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-82	brain-derived neurotrophic factor	Rattus norvegicus	31-35
15607953-6	2005	The phosphatidylinositol 3-kinase (PI 3-K) inhibitors LY294002 and wortmannin prevented phosphorylation of AKT in response to HU-210, and reversed the neuroprotective effect of HU-210 on S-AMPA-induced excitotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
15632060-10	2005	The effects of glucose on V-ATPase trafficking and assembly can be abolished by pretreatment with the PI3K inhibitor LY294002 and can be reproduced in glucose-deprived cells by adenoviral expression of the constitutively active catalytic subunit p110alpha of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	246-255
15671247-6	2005	Inhibition of PI3K with LY294002 or a dominant-negative p85 construct blocked AND-34-mediated Rac and Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	102-105
16037687-9	2005	LY294002, a phosphatidylinositol-3 kinase (P13K)/AKT inhibitor, did suppress the growth of NPC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	49-52
16043966-5	2005	Among inhibitors of intracellular signaling transduction pathways, mitogen-activated protein kinase kinase (MAPKK/MEK) inhibitor PD98059 (40 microM) and p38 MAPK inhibitor SB203580 (5 microM)blocked completely the stimulatory effect of IL-1beta, and the phosphoinositide 3-kinase inhibitor LY294002 (10 microM) blocked partially the induction of IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	290-298	mitogen activated protein kinase 14	Rattus norvegicus	153-156
16925113-6	2005	FAS expression in HepG2 cells was strongly inhibited by PI3K inhibitor LY294002 and JNK inhibitor II and slightly inhibited by p38 inhibitor SB203580 and MEK inhibitor PD98059, separately.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	fatty acid synthase	Homo sapiens	0-3
16706195-4	2005	Accumulation of p27(KiP1) in LY294002-treated E1A + Ras cells was accompanied by a decrease in Cyclin E-Cdk2 and Cyclin A-Cdk2 activity, which caused diminution of Rb phosphorylation and strengthening of E2F-Rb binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	cyclin-dependent kinase 2	Mus musculus	104-108
16293985-5	2005	Reduced thrombin-induced VEGF secretion upon treatment with LY294002, calphostin C, or BAPTA, further suggests that the process is dependent on phosphatidyl-inositol-3-kinase, protein kinase C, and calcium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	coagulation factor II, thrombin	Homo sapiens	8-16
16293985-5	2005	Reduced thrombin-induced VEGF secretion upon treatment with LY294002, calphostin C, or BAPTA, further suggests that the process is dependent on phosphatidyl-inositol-3-kinase, protein kinase C, and calcium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	vascular endothelial growth factor A	Homo sapiens	25-29
15389810-9	2005	The PI3K inhibitor LY294002 seemed to restore the chemosensitivity of native PC-3 cells like WIF-1 did.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	WNT inhibitory factor 1	Homo sapiens	93-98
16706195-4	2005	Accumulation of p27(KiP1) in LY294002-treated E1A + Ras cells was accompanied by a decrease in Cyclin E-Cdk2 and Cyclin A-Cdk2 activity, which caused diminution of Rb phosphorylation and strengthening of E2F-Rb binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	cyclin A2	Mus musculus	113-121
16706195-3	2005	We have shown that suppression of RI3K with LY294002 gave rise to accumulation of cyclin-dependent kinase inhibitor p27(KiP1) but not p21(Waf1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	cyclin-dependent kinase inhibitor 1B	Mus musculus	116-119
16706195-3	2005	We have shown that suppression of RI3K with LY294002 gave rise to accumulation of cyclin-dependent kinase inhibitor p27(KiP1) but not p21(Waf1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	cyclin-dependent kinase inhibitor 1B	Mus musculus	120-124
16706195-4	2005	Accumulation of p27(KiP1) in LY294002-treated E1A + Ras cells was accompanied by a decrease in Cyclin E-Cdk2 and Cyclin A-Cdk2 activity, which caused diminution of Rb phosphorylation and strengthening of E2F-Rb binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	cyclin-dependent kinase 2	Mus musculus	122-126
16706195-4	2005	Accumulation of p27(KiP1) in LY294002-treated E1A + Ras cells was accompanied by a decrease in Cyclin E-Cdk2 and Cyclin A-Cdk2 activity, which caused diminution of Rb phosphorylation and strengthening of E2F-Rb binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	cyclin-dependent kinase inhibitor 1B	Mus musculus	16-19
16706195-4	2005	Accumulation of p27(KiP1) in LY294002-treated E1A + Ras cells was accompanied by a decrease in Cyclin E-Cdk2 and Cyclin A-Cdk2 activity, which caused diminution of Rb phosphorylation and strengthening of E2F-Rb binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	cyclin-dependent kinase inhibitor 1B	Mus musculus	20-24
15539636-5	2004	The LY294002 potentiating effects are completely prevented by betaARK-ct, a peptide inhibitor of beta-adrenergic receptor kinase-1 (betaARK1) as well as G(betagamma) signaling, but not by disrupting G(i) function with pertussis toxin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	G protein-coupled receptor kinase 2	Rattus norvegicus	97-130
15555556-6	2004	Furthermore, we have shown that inhibition of Akt phosphorylation in U937 cells by the specific PI3K inhibitor, LY294002 significantly, enhanced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	AKT serine/threonine kinase 1	Homo sapiens	46-49
15650333-7	2004	The PI3-K inhibitors wortmannin and LY294002 blocked NGF-induced Akt phosphorylation as well as neurite outgrowth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
15496413-10	2004	When the cells were treated with LY294002, an inhibitor of phosphatidylinositol 3-kinase, the HGF-induced lamellipodial formation and migration were abrogated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	hepatocyte growth factor	Mus musculus	94-97
15539636-5	2004	The LY294002 potentiating effects are completely prevented by betaARK-ct, a peptide inhibitor of beta-adrenergic receptor kinase-1 (betaARK1) as well as G(betagamma) signaling, but not by disrupting G(i) function with pertussis toxin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	G protein-coupled receptor kinase 2	Rattus norvegicus	132-140
15297252-6	2004	Treatment with LY-294002 selectively reduced active MMP-2 in media samples according to zymography and Western blot analysis without concomitant changes in latent MMP-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	matrix metallopeptidase 2	Homo sapiens	52-57
15623602-8	2004	Additional analyses using LY294002 and U0126 indicated that the increase in hypoxia-inducible factor 1 (HIF-1)alpha protein level was highly dependent on phosphatidylinositol 3"-kinase and p42/p44 mitogen-activated protein kinase activities in hypoxic MDA-MB-468 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-115
15590928-5	2004	Insulin treatment also led to phosphatidylinositol-3 (PI3) kinase activation evidenced by Akt phosphorylation, which was blocked by PI3 kinase inhibitors, wortmannin and LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-179	thymoma viral proto-oncogene 1	Mus musculus	90-93
15489897-7	2004	However, activation of Akt, but not mTOR was inhibited by the PI-3 kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Homo sapiens	23-26
15659777-8	2004	Blocking the PI3-kinase pathway with wortmannin or LY294002 restores TNFalpha-mediated EC death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	tumor necrosis factor	Homo sapiens	69-77
15498507-6	2004	In particular, blockage of PI3K pathway by LY294002 down-regulated iNOS transcription and steady-state iNOS mRNA levels as well as iNOS mRNA stability induced by catalase, suggesting regulation of PI3K pathway in catalase-induced iNOS expression at the levels of iNOS transcription, steady-state mRNA status, and mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	nitric oxide synthase 2, inducible	Mus musculus	67-71
15498507-6	2004	In particular, blockage of PI3K pathway by LY294002 down-regulated iNOS transcription and steady-state iNOS mRNA levels as well as iNOS mRNA stability induced by catalase, suggesting regulation of PI3K pathway in catalase-induced iNOS expression at the levels of iNOS transcription, steady-state mRNA status, and mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	nitric oxide synthase 2, inducible	Mus musculus	103-107
15498507-5	2004	Of interest, catalase-induced iNOS protein expression was abrogated through inactivation of NF-kappaB pathway by MG132 or BAY 11-7085 and PI3K pathway by LY294002 or wortmannin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	catalase	Mus musculus	13-21
15498507-6	2004	In particular, blockage of PI3K pathway by LY294002 down-regulated iNOS transcription and steady-state iNOS mRNA levels as well as iNOS mRNA stability induced by catalase, suggesting regulation of PI3K pathway in catalase-induced iNOS expression at the levels of iNOS transcription, steady-state mRNA status, and mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	nitric oxide synthase 2, inducible	Mus musculus	103-107
15498507-5	2004	Of interest, catalase-induced iNOS protein expression was abrogated through inactivation of NF-kappaB pathway by MG132 or BAY 11-7085 and PI3K pathway by LY294002 or wortmannin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	nitric oxide synthase 2, inducible	Mus musculus	30-34
15498507-6	2004	In particular, blockage of PI3K pathway by LY294002 down-regulated iNOS transcription and steady-state iNOS mRNA levels as well as iNOS mRNA stability induced by catalase, suggesting regulation of PI3K pathway in catalase-induced iNOS expression at the levels of iNOS transcription, steady-state mRNA status, and mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	catalase	Mus musculus	213-221
15498507-6	2004	In particular, blockage of PI3K pathway by LY294002 down-regulated iNOS transcription and steady-state iNOS mRNA levels as well as iNOS mRNA stability induced by catalase, suggesting regulation of PI3K pathway in catalase-induced iNOS expression at the levels of iNOS transcription, steady-state mRNA status, and mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	nitric oxide synthase 2, inducible	Mus musculus	103-107
15498507-6	2004	In particular, blockage of PI3K pathway by LY294002 down-regulated iNOS transcription and steady-state iNOS mRNA levels as well as iNOS mRNA stability induced by catalase, suggesting regulation of PI3K pathway in catalase-induced iNOS expression at the levels of iNOS transcription, steady-state mRNA status, and mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	nitric oxide synthase 2, inducible	Mus musculus	103-107
15588951-10	2004	In addition, treatment of NPM/ALK+ cells with LY294002, the PI-3K inhibitor, caused elevation of p27Kip1 protein expression and its nuclear localization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	nucleophosmin 1	Mus musculus	26-29
15625017-5	2004	Blockage of PI3K pathway with its specific inhibitor LY294002 caused G1-S phase arrest, decreased cell growth rate and increased chemo- and radio-therapeutic sensitivity in MCF7 cells expressing wild-type p53.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	tumor protein p53	Homo sapiens	205-208
15665505-5	2004	Importantly, pretreatment of PC12 cells with the PI3K inhibitor LY294002, together with the protein kinase A (PKA) inhibitor KT5720, significantly inhibited CGS21680 enhancement of calcium-dependent NPY-Venus release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	neuropeptide Y	Rattus norvegicus	199-202
15610155-6	2004	Application of FKN triggered a 53% reduction of the NMDA-induced neuronal calcium influx, which was insensitive to pertussis toxin and LY294002 an inhibitor of Akt pathway, but abolished by PD98059, an ERK1/2 pathway inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	C-X3-C motif chemokine ligand 1	Homo sapiens	15-18
15610155-7	2004	Moreover, FKN significantly reduced neuronal NMDA-induced apoptosis, which was pertussis toxin insensitive and abolished in presence of PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	C-X3-C motif chemokine ligand 1	Homo sapiens	10-13
15588951-10	2004	In addition, treatment of NPM/ALK+ cells with LY294002, the PI-3K inhibitor, caused elevation of p27Kip1 protein expression and its nuclear localization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	anaplastic lymphoma kinase	Mus musculus	30-33
15588951-10	2004	In addition, treatment of NPM/ALK+ cells with LY294002, the PI-3K inhibitor, caused elevation of p27Kip1 protein expression and its nuclear localization.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	cyclin-dependent kinase inhibitor 1B	Mus musculus	97-104
15574731-5	2004	PKA activity assay and Western blots showed that KT5720, LY294002, and PD98059 almost completely inhibited PKA, PI3K/akt, and MAPK/ERK signal transduction, respectively, whereas AG490 substantially decreased JAK/STAT3 signal transduction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	signal transducer and activator of transcription 3	Homo sapiens	212-217
15579767-10	2004	Cotreatment of cells with wortmannin or LY294002 inhibited the PGE2-induced phosphorylation of Akt and tuberin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	95-98
15579767-10	2004	Cotreatment of cells with wortmannin or LY294002 inhibited the PGE2-induced phosphorylation of Akt and tuberin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	TSC complex subunit 2	Homo sapiens	103-110
15590986-9	2004	Both E2 and raloxifene induced the phosphorylation of Akt, and pre-treatment with a phosphatidylinositol 3-kinase inhibitor, LY294002, attenuated both E2- and raloxifene-induced activation of the telomerase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
15569265-7	2004	Furthermore, the neuroprotective effects of minocycline were blocked by phosphatidylinositol 3-kinase (PI3-K) inhibitors LY294002 and wortmannin, while pharmacologic inhibition of glycogen synthase kinase 3beta (GSK3beta) attenuated glutamate-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	72-101
15610530-9	2004	Treatment with AG490 (Janus tyrosine kinase [JAK] inhibitor) and LY294002 (PI3-Kinase inhibitor) inhibited IL-6-mediated upregulation of bFGF mRNA and protein secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	interleukin 6	Homo sapiens	107-111
15610530-9	2004	Treatment with AG490 (Janus tyrosine kinase [JAK] inhibitor) and LY294002 (PI3-Kinase inhibitor) inhibited IL-6-mediated upregulation of bFGF mRNA and protein secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	fibroblast growth factor 2	Homo sapiens	137-141
15377673-5	2004	PI3K inhibition by LY294002 showed an increase in NAG-1 protein and mRNA expression, and 1l-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate (AKT inhibitor) also induced NAG-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	growth differentiation factor 15	Homo sapiens	50-55
15547762-5	2004	Inhibition of Raf-1 expression by antisense oligonucleotides increased the radiation sensitivity of the radiation-conditioned cells while inhibitors of Ras (L744,832), PI3K (LY294002) and p38 (SB203580) had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-19
15555922-7	2004	Preventing Akt activation with the phosphatidylinositol-3 (PI-3) kinase inhibitor LY294002 blocked the HGF survival response, and inhibition of ERK activation with the MEK inhibitors PD98059 or U0126 reduced the HGF survival response and the neurite growth-promoting effects of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	thymoma viral proto-oncogene 1	Mus musculus	11-14
15555922-7	2004	Preventing Akt activation with the phosphatidylinositol-3 (PI-3) kinase inhibitor LY294002 blocked the HGF survival response, and inhibition of ERK activation with the MEK inhibitors PD98059 or U0126 reduced the HGF survival response and the neurite growth-promoting effects of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	hepatocyte growth factor	Mus musculus	103-106
15377673-5	2004	PI3K inhibition by LY294002 showed an increase in NAG-1 protein and mRNA expression, and 1l-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate (AKT inhibitor) also induced NAG-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	163-166
15377673-5	2004	PI3K inhibition by LY294002 showed an increase in NAG-1 protein and mRNA expression, and 1l-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate (AKT inhibitor) also induced NAG-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	growth differentiation factor 15	Homo sapiens	191-196
15377673-7	2004	Inhibition of GSK-3beta, which is negatively regulated by AKT, using AR-A014418 and lithium chloride completely abolished LY294002-induced NAG-1 expression as well as the NAG-1 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	glycogen synthase kinase 3 beta	Homo sapiens	14-23
15377673-7	2004	Inhibition of GSK-3beta, which is negatively regulated by AKT, using AR-A014418 and lithium chloride completely abolished LY294002-induced NAG-1 expression as well as the NAG-1 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Homo sapiens	58-61
15377673-7	2004	Inhibition of GSK-3beta, which is negatively regulated by AKT, using AR-A014418 and lithium chloride completely abolished LY294002-induced NAG-1 expression as well as the NAG-1 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	growth differentiation factor 15	Homo sapiens	139-144
15377673-8	2004	Furthermore, the down-regulation of GSK-3 gene using small interference RNA resulted in a decline of the NAG-1 expression in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	growth differentiation factor 15	Homo sapiens	105-110
15339911-6	2004	Transcription of cIAP-2 and XIAP was up-regulated by the phosphatidylinositol 3-kinase/Akt pathway as shown by its reversal by dominant-negative Akt or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	baculoviral IAP repeat containing 3	Homo sapiens	17-23
15518647-6	2004	An analysis using a specific inhibitor of phosphatidylinositol 3-kinase (PI3-K), LY294002, revealed that BDNF prevented this cell death via the PI3-K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	42-71
15518647-6	2004	An analysis using a specific inhibitor of phosphatidylinositol 3-kinase (PI3-K), LY294002, revealed that BDNF prevented this cell death via the PI3-K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	brain-derived neurotrophic factor	Rattus norvegicus	105-109
15518647-6	2004	An analysis using a specific inhibitor of phosphatidylinositol 3-kinase (PI3-K), LY294002, revealed that BDNF prevented this cell death via the PI3-K signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	WAP four-disulfide core domain 15B	Rattus norvegicus	73-76
15518647-7	2004	We found that the number of NeuN/TUNEL-double positive cells and the activity of caspase-3 suppressed by BDNF were increased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	RNA binding fox-1 homolog 3	Rattus norvegicus	28-32
15518647-7	2004	We found that the number of NeuN/TUNEL-double positive cells and the activity of caspase-3 suppressed by BDNF were increased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	caspase 3	Rattus norvegicus	81-90
15518647-7	2004	We found that the number of NeuN/TUNEL-double positive cells and the activity of caspase-3 suppressed by BDNF were increased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	brain-derived neurotrophic factor	Rattus norvegicus	105-109
15518647-8	2004	We also discovered that LY294002 diminished the effect of BDNF on the activation of caspase-12, indicating that BDNF prevents ER stress-mediated cell death via a PI3-K-dependent mechanism by suppressing the activation of caspase-12 in cultured CNS neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	brain-derived neurotrophic factor	Rattus norvegicus	58-62
15518647-8	2004	We also discovered that LY294002 diminished the effect of BDNF on the activation of caspase-12, indicating that BDNF prevents ER stress-mediated cell death via a PI3-K-dependent mechanism by suppressing the activation of caspase-12 in cultured CNS neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	caspase 12	Rattus norvegicus	84-94
15518647-8	2004	We also discovered that LY294002 diminished the effect of BDNF on the activation of caspase-12, indicating that BDNF prevents ER stress-mediated cell death via a PI3-K-dependent mechanism by suppressing the activation of caspase-12 in cultured CNS neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	brain-derived neurotrophic factor	Rattus norvegicus	112-116
15518647-8	2004	We also discovered that LY294002 diminished the effect of BDNF on the activation of caspase-12, indicating that BDNF prevents ER stress-mediated cell death via a PI3-K-dependent mechanism by suppressing the activation of caspase-12 in cultured CNS neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	caspase 12	Rattus norvegicus	221-231
15339911-6	2004	Transcription of cIAP-2 and XIAP was up-regulated by the phosphatidylinositol 3-kinase/Akt pathway as shown by its reversal by dominant-negative Akt or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	X-linked inhibitor of apoptosis	Homo sapiens	28-32
15339911-6	2004	Transcription of cIAP-2 and XIAP was up-regulated by the phosphatidylinositol 3-kinase/Akt pathway as shown by its reversal by dominant-negative Akt or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	AKT serine/threonine kinase 1	Homo sapiens	87-90
15631803-13	2004	15 micromol/L LY294002 completely blocked the bFGF-induced phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	fibroblast growth factor 2	Homo sapiens	46-50
15480428-6	2004	The RTKN-mediated antiapoptotic effect was blocked by the nuclear factor-kappaB (NF-kappaB) inhibitors, curcumin or parthenolide, but not by the phosphatidylinositol 3"-OH-kinase inhibitor, LY294002, or the MAP kinase inhibitor, PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	rhotekin	Homo sapiens	4-8
15631803-13	2004	15 micromol/L LY294002 completely blocked the bFGF-induced phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	78-81
15631803-16	2004	SU5402 and LY294002 100% inhibited the bFGF-induced expression of HIF-1alpha protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	fibroblast growth factor 2	Homo sapiens	39-43
15271800-4	2004	A phosphatidyl inositol-3 (PI-3) kinase inhibitor, LY294002, inhibited IL-2-rescued survival, but a mitogen-activated protein kinase inhibitor, PD98059, and an inhibitor of Janus tyrosine kinase/signal transducer and activator of transcription pathway, AG490, did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	interleukin 2	Homo sapiens	71-75
15631803-16	2004	SU5402 and LY294002 100% inhibited the bFGF-induced expression of HIF-1alpha protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-76
15271800-5	2004	LY294002 inhibited IL-2-induced reduction of ceramide through activation of acid SMase and inhibition of GCS and SMS, suggesting the positive involvement of PI-3 kinase in ceramide reduction through enzymatic regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 2	Homo sapiens	19-23
15631803-19	2004	LY294002 not only completely inhibited the bFGF-induced transcription activity of HIF-1 but also inhibited the basic transcription of HIF-1, and SB203580 did not significantly influence the transcription activity of HIF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	fibroblast growth factor 2	Homo sapiens	43-47
15271800-5	2004	LY294002 inhibited IL-2-induced reduction of ceramide through activation of acid SMase and inhibition of GCS and SMS, suggesting the positive involvement of PI-3 kinase in ceramide reduction through enzymatic regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	UDP-glucose ceramide glucosyltransferase	Homo sapiens	105-108
15631803-19	2004	LY294002 not only completely inhibited the bFGF-induced transcription activity of HIF-1 but also inhibited the basic transcription of HIF-1, and SB203580 did not significantly influence the transcription activity of HIF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-87
15271800-7	2004	Further, LY294002 inhibited IL-2-induced changes of transcriptional level as well as mRNA and protein levels in acid SMase and GCS but did not affect the stability of the mRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	interleukin 2	Homo sapiens	28-32
15271800-7	2004	Further, LY294002 inhibited IL-2-induced changes of transcriptional level as well as mRNA and protein levels in acid SMase and GCS but did not affect the stability of the mRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	UDP-glucose ceramide glucosyltransferase	Homo sapiens	127-130
15631803-19	2004	LY294002 not only completely inhibited the bFGF-induced transcription activity of HIF-1 but also inhibited the basic transcription of HIF-1, and SB203580 did not significantly influence the transcription activity of HIF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-139
15631803-19	2004	LY294002 not only completely inhibited the bFGF-induced transcription activity of HIF-1 but also inhibited the basic transcription of HIF-1, and SB203580 did not significantly influence the transcription activity of HIF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-139
15548697-7	2004	Interestingly, LY294002, but not PD98059, inhibited wild-type EGFR pTyr in response to EGF treatment in U87MG parental cells and in wild-type EGFR-overexpressing U87MG cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	epidermal growth factor receptor	Homo sapiens	62-66
15548697-7	2004	Interestingly, LY294002, but not PD98059, inhibited wild-type EGFR pTyr in response to EGF treatment in U87MG parental cells and in wild-type EGFR-overexpressing U87MG cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	epidermal growth factor receptor	Homo sapiens	142-146
15548697-9	2004	However, LY294002 more specifically inhibited wild-type EGFR pTyr at residues Tyr(992) and Tyr(1068) in the COOH terminus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	epidermal growth factor receptor	Homo sapiens	56-60
15449318-5	2004	These results contrasted with hormone-dependent activation of the SRE in the c-fos promoter, which was inhibited by both PD98059 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-82
15389877-5	2004	Moreover, inhibition of Akt or ERK activity with respectively a PI-3K inhibitor (LY294002) or MEK inhibitors (PD98059, UO126), partially or totally suppressed the anti-apoptotic capacity of 1,25(OH)2D3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	24-27
15389877-5	2004	Moreover, inhibition of Akt or ERK activity with respectively a PI-3K inhibitor (LY294002) or MEK inhibitors (PD98059, UO126), partially or totally suppressed the anti-apoptotic capacity of 1,25(OH)2D3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	mitogen-activated protein kinase 1	Homo sapiens	31-34
15328362-3	2004	Treatment with the reversible PI3K inhibitor, LY294002, or more specific inhibition of class I(A) PI3K via regulated expression of dominant negative Deltap85, led to a reduction in the ability of LIF to maintain self-renewal, with cells concomitantly adopting a differentiated morphology.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	leukemia inhibitory factor	Mus musculus	196-199
15328362-5	2004	Importantly, LY294002 and Deltap85 expression had no effect on LIF-induced phosphorylation of STAT3 at Tyr(705), but did augment LIF-induced phosphorylation of ERKs in both short and long term incubations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	leukemia inhibitory factor	Mus musculus	129-132
15569997-4	2004	We show an association between Akt and IKK and show that the phosphorylation of IKK induced by paclitaxel is blocked by treatment with a phosphatidylinositol 3-kinase inhibitor (wortmannin or LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	192-200	AKT serine/threonine kinase 1	Homo sapiens	31-34
15465038-4	2004	The phosphatidylinositol 3-kinase (PI3K) signaling pathway was also involved since the PI3K inhibitor, LY294002, abolished the TIMP-1-mediated growth stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-33
15465038-4	2004	The phosphatidylinositol 3-kinase (PI3K) signaling pathway was also involved since the PI3K inhibitor, LY294002, abolished the TIMP-1-mediated growth stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	TIMP metallopeptidase inhibitor 1	Homo sapiens	127-133
15337530-3	2004	The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT activations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	Insulin-like receptor	Drosophila melanogaster	4-11
15337530-3	2004	The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT activations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	rolled	Drosophila melanogaster	35-39
15337530-3	2004	The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT activations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	Akt1	Drosophila melanogaster	143-147
15337530-3	2004	The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT activations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	Akt1	Drosophila melanogaster	44-48
15337530-3	2004	The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT activations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	Insulin-like receptor	Drosophila melanogaster	155-162
15337530-3	2004	The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT activations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	rolled	Drosophila melanogaster	171-175
15337530-3	2004	The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT activations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	Akt1	Drosophila melanogaster	45-48
15337530-3	2004	The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT activations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	Akt1	Drosophila melanogaster	143-147
15337530-5	2004	The insulin-stimulated size increase was blocked by both LY294002 and AKT inhibitor, not by U0126, indicating that insulin-mediated size control by dPI3K and dAKT occurs independently of the ERK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	Insulin-like receptor	Drosophila melanogaster	4-11
15337530-3	2004	The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT activations.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	Pi3K21B	Drosophila melanogaster	133-138
15337530-5	2004	The insulin-stimulated size increase was blocked by both LY294002 and AKT inhibitor, not by U0126, indicating that insulin-mediated size control by dPI3K and dAKT occurs independently of the ERK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	Insulin-like receptor	Drosophila melanogaster	115-122
15345706-8	2004	The overexpression of dysbindin increased phosphorylation of Akt protein and protected cortical neurons against neuronal death due to serum deprivation and these effects were blocked by LY294002, a phosphatidylinositol 3-kinase (PI3-kinase) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	dystrobrevin binding protein 1	Homo sapiens	22-31
15345706-8	2004	The overexpression of dysbindin increased phosphorylation of Akt protein and protected cortical neurons against neuronal death due to serum deprivation and these effects were blocked by LY294002, a phosphatidylinositol 3-kinase (PI3-kinase) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-194	AKT serine/threonine kinase 1	Homo sapiens	61-64
15194708-0	2004	LY-294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] affects calcium signaling in airway smooth muscle cells independently of phosphoinositide 3-kinase inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	134-159
15838275-5	2004	The endothelin-1- induced attenuation was very strongly suppressed by co-incubation with J-104132, endothelin receptor A/B antagonist, or polyethylene-glycolated superoxide dismutase, a cell-permeant superoxide anion scavenger or LY294002, phosphoinositide 3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	230-238	endothelin 1	Rattus norvegicus	4-16
15514257-6	2004	Pretreatment with two PI3K inhibitors, LY294002 and wortmannin, abolished the activation of NFkappaB by 1,25(OH)(2)D(3), suggesting that this pathway is essential for NFkappaB transcriptional activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	92-100
15514257-6	2004	Pretreatment with two PI3K inhibitors, LY294002 and wortmannin, abolished the activation of NFkappaB by 1,25(OH)(2)D(3), suggesting that this pathway is essential for NFkappaB transcriptional activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	167-175
15824471-7	2004	HGF also stimulated Akt phosphorylation (Ser-473), which was completely suppressed by LY294002 and was partially suppressed by U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	hepatocyte growth factor	Bos taurus	0-3
15824471-7	2004	HGF also stimulated Akt phosphorylation (Ser-473), which was completely suppressed by LY294002 and was partially suppressed by U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	AKT serine/threonine kinase 1	Bos taurus	20-23
15824471-8	2004	Moreover, HGF stimulated extracellular signal-regulated kinase 1/2 phosphorylation (Thr-202/Tyr-204), which was completely suppressed by U0126 and was partially suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	hepatocyte growth factor	Bos taurus	10-13
15824471-8	2004	Moreover, HGF stimulated extracellular signal-regulated kinase 1/2 phosphorylation (Thr-202/Tyr-204), which was completely suppressed by U0126 and was partially suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	mitogen-activated protein kinase 3	Bos taurus	25-64
15838284-7	2004	Moreover, ET-1 activated NSCC-1 in CHO-ETAR treated with LY 294002, the phosphoinositide 3-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-66	endothelin-1	Cricetulus griseus	10-14
15328334-4	2004	These GM-CSF-triggered changes were abrogated, and Fas-induced apoptosis was restored by an inhibitor of classical protein kinase C (PKC), Go6976, and by the combination of a phosphatidylinositol 3-kinase (PI-3K) inhibitor, LY294002, and an inhibitor of mitogen-activated protein kinase kinase (MEK)1, PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	colony stimulating factor 2	Homo sapiens	6-12
15328334-4	2004	These GM-CSF-triggered changes were abrogated, and Fas-induced apoptosis was restored by an inhibitor of classical protein kinase C (PKC), Go6976, and by the combination of a phosphatidylinositol 3-kinase (PI-3K) inhibitor, LY294002, and an inhibitor of mitogen-activated protein kinase kinase (MEK)1, PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	175-204
15194708-8	2004	The specific casein kinase-2 (CK2) inhibitor 5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazole (10-40 microM) reduced 5-HT-triggered responses to a similar extent as LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-175	casein kinase 2 beta	Rattus norvegicus	13-28
15194708-9	2004	We conclude that LY-294002 modulates Ca(2+) signaling in rat ASM independently of its action on PI3K by acting on, or upstream of, PLC, possibly by inhibiting CK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-26	casein kinase 2 beta	Rattus norvegicus	159-162
15292274-5	2004	Surprisingly, although rapamycin, RAD001, wortmannin, and LY294002 inhibited the phosphorylation of 4E-BP1 and its release from eIF4E, they did not prevent the recovery of translation rates.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	100-106
15566969-7	2004	While the JAK inhibitor AG490, the PI3K inhibitor LY294002, and the NFkappaB inhibitor PDTC abrogated almost completely the expression of iNOS induced by MSU, the ERK1/2 inhibitor PD98059 was only partially effective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	nitric oxide synthase 2	Homo sapiens	138-142
15472100-6	2004	RESULTS: A transient increase in ILK was detected early after tFCI and was prevented by treatment with LY294002, but promoted by SOD1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	integrin linked kinase	Mus musculus	33-36
15472100-8	2004	Moreover, the ILK/Akt complex was prevented by LY294002, but promoted by SOD1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	integrin linked kinase	Mus musculus	14-17
15472100-8	2004	Moreover, the ILK/Akt complex was prevented by LY294002, but promoted by SOD1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	thymoma viral proto-oncogene 1	Mus musculus	18-21
15292274-5	2004	Surprisingly, although rapamycin, RAD001, wortmannin, and LY294002 inhibited the phosphorylation of 4E-BP1 and its release from eIF4E, they did not prevent the recovery of translation rates.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	eukaryotic translation initiation factor 4E	Homo sapiens	128-133
15337760-4	2004	We found that inhibition of PI3K activity by LY294002 decreased VEGF transcriptional activation and that forced expression of AKT completely reversed the inhibitory effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	vascular endothelial growth factor A	Homo sapiens	64-68
15466647-10	2004	This in situ Akt phosphorylation was abolished significantly after injection of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
15337760-6	2004	The inhibition of PI3K by LY294002 inhibited p70S6K1 and HDM2 activity in the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	MDM2 proto-oncogene	Homo sapiens	57-61
15337760-7	2004	Forced expression of p70S6K1 or HDM2 reversed LY294002-inhibited VEGF transcriptional activation and HIF-1alpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	MDM2 proto-oncogene	Homo sapiens	32-36
15337760-7	2004	Forced expression of p70S6K1 or HDM2 reversed LY294002-inhibited VEGF transcriptional activation and HIF-1alpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	vascular endothelial growth factor A	Homo sapiens	65-69
15337760-7	2004	Forced expression of p70S6K1 or HDM2 reversed LY294002-inhibited VEGF transcriptional activation and HIF-1alpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-111
15292252-9	2004	Bcl-2 expression was markedly elevated in VEGF-treated HDMECs, and it was significantly inhibited by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	BCL2 apoptosis regulator	Homo sapiens	0-5
15451068-6	2004	LY294002, a PI3 kinase inhibitor, enhances Akt inactivation and DNA fragmentation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	43-46
15292252-9	2004	Bcl-2 expression was markedly elevated in VEGF-treated HDMECs, and it was significantly inhibited by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	vascular endothelial growth factor A	Homo sapiens	42-46
15367412-6	2004	The PTEN-negative cell line displayed greater sensitivity to the growth inhibitory effects of the PI3K inhibitor, LY294002 and rapamycin, an inhibitor of the PI3K/Akt downstream mediator mTOR, compared with the PTEN-positive cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	phosphatase and tensin homolog	Homo sapiens	4-8
15304489-4	2004	The phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, reduced both basal and IGF-1-stimulated RUNX2 DNA binding activity in the absence of changes in RUNX2 protein as did the overexpression of the phosphatidylinositol 3-phosphate phosphatase, confirming that PI3K signaling mediates RUNX2 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-33
15304489-4	2004	The phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, reduced both basal and IGF-1-stimulated RUNX2 DNA binding activity in the absence of changes in RUNX2 protein as did the overexpression of the phosphatidylinositol 3-phosphate phosphatase, confirming that PI3K signaling mediates RUNX2 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	insulin like growth factor 1	Homo sapiens	85-90
15304489-4	2004	The phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, reduced both basal and IGF-1-stimulated RUNX2 DNA binding activity in the absence of changes in RUNX2 protein as did the overexpression of the phosphatidylinositol 3-phosphate phosphatase, confirming that PI3K signaling mediates RUNX2 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	RUNX family transcription factor 2	Homo sapiens	102-107
15371228-4	2004	Conversely, the phosphatidylinositol 3-kinase (PI3 kinase) inhibitor LY294002 and a selective PKCzeta inhibitory peptide decreased TF mRNA expression in asbestos-treated cells to a greater extent than in naive cells, suggesting that signaling via this pathway contributes to asbestos-induced TF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	coagulation factor III, tissue factor	Homo sapiens	131-133
15371228-4	2004	Conversely, the phosphatidylinositol 3-kinase (PI3 kinase) inhibitor LY294002 and a selective PKCzeta inhibitory peptide decreased TF mRNA expression in asbestos-treated cells to a greater extent than in naive cells, suggesting that signaling via this pathway contributes to asbestos-induced TF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	coagulation factor III, tissue factor	Homo sapiens	292-294
15208094-4	2004	Na+ transport increases within 5 min of cAMP stimulation and is sustained for &gt;24 h. The sustained effect of cAMP on Na+ transport is abolished by LY-294002, an inhibitor of phosphatidylinositol 3-kinase, by H89, an inhibitor of PKA, or by SB-202190, an inhibitor of p38 MAP kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-159	mitogen-activated protein kinase 14	Homo sapiens	270-273
15308628-7	2004	In contrast, VEGF-mediated induction of Mn-SOD was enhanced by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and by dominant negative Akt and was decreased by constitutively active Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	vascular endothelial growth factor A	Homo sapiens	13-17
15308628-7	2004	In contrast, VEGF-mediated induction of Mn-SOD was enhanced by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and by dominant negative Akt and was decreased by constitutively active Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	superoxide dismutase 2	Homo sapiens	40-46
15155260-4	2004	Inhibition of Akt [indirectly via phosphatidylinositol 3-kinase with LY-294002 or wortmannin] or PKC (with bisindolylmaleimide) reduced VEGF-induced hyperpermeability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-78	vascular endothelial growth factor A	Homo sapiens	136-140
15367412-8	2004	These reduced PTEN cells demonstrated an increased sensitivity to the anti-proliferative effects induced by LY294002 and rapamycin compared with the parental cells, which corresponded to alterations in cell cycle response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	phosphatase and tensin homolog	Homo sapiens	14-18
15367412-6	2004	The PTEN-negative cell line displayed greater sensitivity to the growth inhibitory effects of the PI3K inhibitor, LY294002 and rapamycin, an inhibitor of the PI3K/Akt downstream mediator mTOR, compared with the PTEN-positive cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Homo sapiens	163-166
15590482-10	2004	The cell-survival activity of CNTF was blocked by 10 ng/ml LY294002 (Dunnet"s test, p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	ciliary neurotrophic factor	Rattus norvegicus	30-34
15240007-6	2004	The Erk1/2 inhibitor PD98059 and the p38 inhibitor SB203580 inhibited TIMP-1 mRNA response to muOSM, whereas the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 enhanced the TIMP-1 mRNA response in NIH 3T3 and MLg cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	113-138
15240011-5	2004	BK-induced MMP-9 mRNA and protein expression was inhibited by MEK1/2 inhibitor PD98059, PI3-K inhibitor LY294002, and NF-kappaB inhibitor helenalin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	matrix metallopeptidase 9	Rattus norvegicus	11-16
15240011-6	2004	In accordance with these findings, BK-induced phosphorylation of p42/p44 MAPK and Akt and activation of NF-kappaB was attenuated by prior treatment with PD98059, LY294002, and helenalin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	mitogen activated protein kinase 3	Rattus norvegicus	69-77
15590482-11	2004	In vivo, the neuroprotective activity of CNTF in constant-light conditions was attenuated by 10 microg/eye LY294002 (Dunnet"s test, p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	ciliary neurotrophic factor	Rattus norvegicus	41-45
15367896-10	2004	Cultivation of HPCs in a differentiation medium supplemented with nicotinamide, exendin-4, and/or LY294002, an inhibitor of phosphatidylinositol-3 kinase, stimulated expression of insulin mRNA and protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	insulin	Homo sapiens	180-187
15473891-3	2004	RESULTS: We found that in VSMCs from humans and from insulin-sensitive Zucker fa/+rats, insulin increases VEGF protein expression and secretion, with mechanisms blunted by wortmannin and LY294002 (PI3-K inhibitors), PD98059 (MAPK inhibitor), L-NMMA (NOS inhibitor) and Rp-8pCT-cGMPs (PKG inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	insulin	Homo sapiens	53-60
15473891-3	2004	RESULTS: We found that in VSMCs from humans and from insulin-sensitive Zucker fa/+rats, insulin increases VEGF protein expression and secretion, with mechanisms blunted by wortmannin and LY294002 (PI3-K inhibitors), PD98059 (MAPK inhibitor), L-NMMA (NOS inhibitor) and Rp-8pCT-cGMPs (PKG inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	insulin	Homo sapiens	88-95
15473891-3	2004	RESULTS: We found that in VSMCs from humans and from insulin-sensitive Zucker fa/+rats, insulin increases VEGF protein expression and secretion, with mechanisms blunted by wortmannin and LY294002 (PI3-K inhibitors), PD98059 (MAPK inhibitor), L-NMMA (NOS inhibitor) and Rp-8pCT-cGMPs (PKG inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	vascular endothelial growth factor A	Rattus norvegicus	106-110
15473891-3	2004	RESULTS: We found that in VSMCs from humans and from insulin-sensitive Zucker fa/+rats, insulin increases VEGF protein expression and secretion, with mechanisms blunted by wortmannin and LY294002 (PI3-K inhibitors), PD98059 (MAPK inhibitor), L-NMMA (NOS inhibitor) and Rp-8pCT-cGMPs (PKG inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	protein kinase cGMP-dependent 1	Homo sapiens	284-287
15313431-4	2004	We found that C5a-induced, time-dependent (1) ERK1/2 phosphorylation was markedly diminished by PTX, U73122, P13K inhibitors wortmannin and LY294002 and ERK1/2 inhibitor PD98059; (2) Akt phosphorylation was also attenuated by the above inhibitors except PD98059; (3) p38 MAPK phosphorylation was only affected by PTX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	complement C5a receptor 1	Homo sapiens	14-17
15313431-4	2004	We found that C5a-induced, time-dependent (1) ERK1/2 phosphorylation was markedly diminished by PTX, U73122, P13K inhibitors wortmannin and LY294002 and ERK1/2 inhibitor PD98059; (2) Akt phosphorylation was also attenuated by the above inhibitors except PD98059; (3) p38 MAPK phosphorylation was only affected by PTX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	mitogen-activated protein kinase 3	Homo sapiens	46-52
15452065-9	2004	PI-3K inhibitors wortmannin and LY294002 blocked the IGF-1 effect on cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	insulin-like growth factor I	Oryctolagus cuniculus	53-58
15380678-7	2004	Prevention of apoptosis by Gas6-Axl required activation of phosphatidyl inositol 3-kinase (PI3K) as shown by treatment with LY294002 or transfection of an Axl deletion mutant that does not bind PI3K (Axl- triangle up PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	growth arrest specific 6	Rattus norvegicus	27-31
15380678-7	2004	Prevention of apoptosis by Gas6-Axl required activation of phosphatidyl inositol 3-kinase (PI3K) as shown by treatment with LY294002 or transfection of an Axl deletion mutant that does not bind PI3K (Axl- triangle up PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	Axl receptor tyrosine kinase	Rattus norvegicus	32-35
15380678-7	2004	Prevention of apoptosis by Gas6-Axl required activation of phosphatidyl inositol 3-kinase (PI3K) as shown by treatment with LY294002 or transfection of an Axl deletion mutant that does not bind PI3K (Axl- triangle up PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	59-89
15319269-4	2004	Activation of Akt and eNOS by HF was completely blocked by the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, LY294002 (10 micromol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	AKT serine/threonine kinase 1	Homo sapiens	14-17
15319270-4	2004	METHODS AND RESULTS: Wortmannin and LY294002 were used to inhibit the PI3K-Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	thymoma viral proto-oncogene 1	Mus musculus	75-78
15319373-7	2004	Further, the PI-3 kinase inhibitor LY294002 and MAPK inhibitor PD98059 were found to significantly reduce leptin-induced HSC proliferation, thereby indicating that leptin induced HSC proliferation is Akt- and Erk-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	leptin	Homo sapiens	106-112
15319373-7	2004	Further, the PI-3 kinase inhibitor LY294002 and MAPK inhibitor PD98059 were found to significantly reduce leptin-induced HSC proliferation, thereby indicating that leptin induced HSC proliferation is Akt- and Erk-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	leptin	Homo sapiens	164-170
15319373-7	2004	Further, the PI-3 kinase inhibitor LY294002 and MAPK inhibitor PD98059 were found to significantly reduce leptin-induced HSC proliferation, thereby indicating that leptin induced HSC proliferation is Akt- and Erk-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	200-203
15319373-7	2004	Further, the PI-3 kinase inhibitor LY294002 and MAPK inhibitor PD98059 were found to significantly reduce leptin-induced HSC proliferation, thereby indicating that leptin induced HSC proliferation is Akt- and Erk-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	mitogen-activated protein kinase 1	Homo sapiens	209-212
15385469-6	2004	For both bacterial molecules, blocking phosphatidylinositol 3-kinase (PI3-K; Ly294002) or Janus kinase 2 (JAK-2; AG490) particularly affected the induction of IL-6 and IL-10 release, whereas TNF-alpha levels were strongly reduced by inhibition of Src family tyrosine kinases (PP2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	39-68
15385469-6	2004	For both bacterial molecules, blocking phosphatidylinositol 3-kinase (PI3-K; Ly294002) or Janus kinase 2 (JAK-2; AG490) particularly affected the induction of IL-6 and IL-10 release, whereas TNF-alpha levels were strongly reduced by inhibition of Src family tyrosine kinases (PP2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	interleukin 6	Rattus norvegicus	159-163
15385469-6	2004	For both bacterial molecules, blocking phosphatidylinositol 3-kinase (PI3-K; Ly294002) or Janus kinase 2 (JAK-2; AG490) particularly affected the induction of IL-6 and IL-10 release, whereas TNF-alpha levels were strongly reduced by inhibition of Src family tyrosine kinases (PP2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	interleukin 10	Rattus norvegicus	168-173
15452053-9	2004	In the presence of phosphatidylinositol-3 kinase (PI-3K) inhibitors (wortmannin and LY294002), HGF did not overcome apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	hepatocyte growth factor	Oryctolagus cuniculus	95-98
15378648-5	2004	RET/PTC3 cells demonstrated higher basal and insulin-stimulated levels of activated Akt, both of which were reduced by LY294002, a PI3 kinase inhibitor, but not PD98059, a MEK inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	ret proto-oncogene	Rattus norvegicus	0-3
15378648-5	2004	RET/PTC3 cells demonstrated higher basal and insulin-stimulated levels of activated Akt, both of which were reduced by LY294002, a PI3 kinase inhibitor, but not PD98059, a MEK inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Rattus norvegicus	84-87
15378648-8	2004	RET/PTC3 cells were also sensitized to insulin-induced thymidine incorporation; this effect was blocked by PI3 kinase (LY294002) rather than MEK 1/2 (PD98059) inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	ret proto-oncogene	Rattus norvegicus	0-3
15385613-6	2004	Capsaicin and NGF induce phosphorylation of the PI3K downstream target AKT (protein kinase B), which is blocked by the PI3K inhibitors LY294002 and wortmannin, indicative of the activation of PI3K by both agents.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Rattus norvegicus	71-74
15634518-3	2004	Expression of HER2/neu, p53, Akt and p-Akt protein after PI3K pathway inhibitor LY294002 treatment was determined by Western blot.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-22
15634518-3	2004	Expression of HER2/neu, p53, Akt and p-Akt protein after PI3K pathway inhibitor LY294002 treatment was determined by Western blot.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	39-42
15634518-6	2004	HER2/neu overexpressing MCF7 cells showed higher p-Akt expression and lower p53 expression than those of parental MCF7 cells, which could be abrogated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
15634518-6	2004	HER2/neu overexpressing MCF7 cells showed higher p-Akt expression and lower p53 expression than those of parental MCF7 cells, which could be abrogated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Homo sapiens	51-54
15634518-6	2004	HER2/neu overexpressing MCF7 cells showed higher p-Akt expression and lower p53 expression than those of parental MCF7 cells, which could be abrogated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	tumor protein p53	Homo sapiens	76-79
15634518-7	2004	HER2/neu overexpressing MCF7 cells had higher proliferation rate and lower sensitivity to gamma-irradiation than those of parental MCF7 cells, which could be opposed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
15286700-10	2004	Overexpression of a constitutively activated Akt (myristoylated Akt) in W53 cells overcame the inhibitory effect of LY294002 on c-Myc expression, as well as cell death upon PRL deprivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	thymoma viral proto-oncogene 1	Mus musculus	45-48
15286700-10	2004	Overexpression of a constitutively activated Akt (myristoylated Akt) in W53 cells overcame the inhibitory effect of LY294002 on c-Myc expression, as well as cell death upon PRL deprivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	thymoma viral proto-oncogene 1	Mus musculus	64-67
15317677-6	2004	In addition, both of the phosphatidylinositol 3-kinase inhibitors wortmannin and LY-294002 abolished the ANG II-induced increase in protein synthesis, and wortmannin also blocked p70(S6k) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-90	angiotensinogen	Homo sapiens	105-111
15302591-5	2004	Inhibition with PD98059 and LY294002 independently prevented HGF-induced invasive growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	hepatocyte growth factor	Homo sapiens	61-64
15187029-6	2004	Using PP1 in combination with the inhibitor of PI 3-kinase LY294002, we show that Src negatively regulates the PI 3-kinase-mediated component of the P2Y(12) calcium response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	82-85
15105162-6	2004	Inhibition of PI(3) kinase or mTOR with LY294002 or rapamycin blocked p70S6K activation, prevented formation of large elongated contractile phenotype myocytes, and blocked accumulation of SM22 and smMHC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	mechanistic target of rapamycin kinase	Homo sapiens	30-34
15105162-6	2004	Inhibition of PI(3) kinase or mTOR with LY294002 or rapamycin blocked p70S6K activation, prevented formation of large elongated contractile phenotype myocytes, and blocked accumulation of SM22 and smMHC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	ribosomal protein S6 kinase B1	Homo sapiens	70-76
15105162-6	2004	Inhibition of PI(3) kinase or mTOR with LY294002 or rapamycin blocked p70S6K activation, prevented formation of large elongated contractile phenotype myocytes, and blocked accumulation of SM22 and smMHC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	transgelin	Homo sapiens	188-192
15105162-6	2004	Inhibition of PI(3) kinase or mTOR with LY294002 or rapamycin blocked p70S6K activation, prevented formation of large elongated contractile phenotype myocytes, and blocked accumulation of SM22 and smMHC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	myosin heavy chain 11	Homo sapiens	197-202
15317677-6	2004	In addition, both of the phosphatidylinositol 3-kinase inhibitors wortmannin and LY-294002 abolished the ANG II-induced increase in protein synthesis, and wortmannin also blocked p70(S6k) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-90	ribosomal protein S6 kinase B1	Homo sapiens	183-186
15377841-4	2004	High levels of basal Akt, GSK3 alpha / beta and p70S6 kinase phosphorylation are all inhibited by the PI3 kinase inhibitor, LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-133	AKT serine/threonine kinase 1	Homo sapiens	21-24
15377841-4	2004	High levels of basal Akt, GSK3 alpha / beta and p70S6 kinase phosphorylation are all inhibited by the PI3 kinase inhibitor, LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-133	glycogen synthase kinase 3 alpha	Homo sapiens	26-36
15192040-8	2004	Pretreatment with the PI3K inhibitor LY294002 or knockdown of p85 with small interfering RNA inhibited IGF-I or TGFalpha-stimulated IGFBP-3 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	transforming growth factor alpha	Bos taurus	112-120
15192040-8	2004	Pretreatment with the PI3K inhibitor LY294002 or knockdown of p85 with small interfering RNA inhibited IGF-I or TGFalpha-stimulated IGFBP-3 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	IGFI	Bos taurus	103-108
15090468-6	2004	NF-kappaB translocation inhibitor SN50 and phosphatidylinositol 3-kinase (PI3) inhibitor LY294002 decreased the induction of GSTA1 by sulforaphane almost to baseline level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	glutathione S-transferase alpha 1	Homo sapiens	125-130
15155571-11	2004	Then, AQP2 moved from EEA1-positive endosomes to the subapical AQP2-storage compartment, which is sensitive to wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	aquaporin 2	Canis lupus familiaris	6-10
15192040-8	2004	Pretreatment with the PI3K inhibitor LY294002 or knockdown of p85 with small interfering RNA inhibited IGF-I or TGFalpha-stimulated IGFBP-3 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	insulin like growth factor binding protein 3	Bos taurus	132-139
15155571-11	2004	Then, AQP2 moved from EEA1-positive endosomes to the subapical AQP2-storage compartment, which is sensitive to wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	aquaporin 2	Canis lupus familiaris	63-67
15763944-6	2004	In addition, the prevention of cell death in this model system seems to be dependent on the activation of phosphatidylinositol 3-kinase (PI3K)/Akt, as Ang-1 fails to inhibit DOX-induced cell death while PI3K/Akt pathway was blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	254-262	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	106-135
15166121-8	2004	Leptin"s antiapoptotic activity required Janus kinase/STAT, MAPK, and phosphatidylinositol-3-kinase activation because the antiapoptotic effects of leptin were abolished, and caspase-3 immunoreactivity increased in the presence of the specific blockers AG490, U0126, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	270-278	leptin	Homo sapiens	0-6
15278907-3	2004	In follicle-stimulating hormone (FSH)-induced reversal of hypoxanthine-mediated meiotic arrest of cumulus oocyte complexes (COCs), LY294002 suppressed germinal vesicle breakdown (GVBD), first polar body (PB1) emission, and cumulus expansion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	adhesion G protein-coupled receptor G3	Mus musculus	204-207
15289868-5	2004	Although Ly294002 by itself had only a modest effect on cell death in BT-20 and MCF-7 cells, it potentiated sensitivity of these cells to TNF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	tumor necrosis factor	Homo sapiens	138-141
15341518-7	2004	However, administration of LY294002, an inhibitor of phosphatidylinositol 3 kinase (PI3K), blocked the phosphorylation of Akt but did not affect the effect of NT3 on the expression of Olig-1 and on NSC differentiation into OLPs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	53-82
15341518-7	2004	However, administration of LY294002, an inhibitor of phosphatidylinositol 3 kinase (PI3K), blocked the phosphorylation of Akt but did not affect the effect of NT3 on the expression of Olig-1 and on NSC differentiation into OLPs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	122-125
15278907-10	2004	LY294002 decreased the amount of Thr(308) phosphorylated Akt to very low to undetectable levels in MI and MII oocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	57-60
15278907-11	2004	Ser(473) phosphorylated Akt showed aberrant distribution and very low to undetectable levels of expression in LY294002-treated MI and MII oocytes, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	thymoma viral proto-oncogene 1	Mus musculus	24-27
15362046-12	2004	We also observed that, by impairing PI3K-mediated activation of phospholypase Cgamma (PLCgamma), wortmannin and LY294002 blocked the downstream transduction of preconditioning signals via protein kinase C (PKC) delta/ isozymes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	protein kinase C, delta	Rattus norvegicus	188-216
15329376-6	2004	Inhibition of the MAP Kinase/ERK pathway had no influence on cell survival, but inhibition of phosphatidylinositol 3 kinase (PI3-Kinase; Akt/protein kinase B) by LY294002 amplified TEGDMA-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	AKT serine/threonine kinase 1	Homo sapiens	137-140
15329376-6	2004	Inhibition of the MAP Kinase/ERK pathway had no influence on cell survival, but inhibition of phosphatidylinositol 3 kinase (PI3-Kinase; Akt/protein kinase B) by LY294002 amplified TEGDMA-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	protein tyrosine kinase 2 beta	Homo sapiens	141-157
15333786-9	2004	Interfering with either signalling pathway via PI3K inhibitor LY294002 or MEK inhibitor U0126 in EGF-stimulated HTR8/SVneo cells blocked the induction of MMP-9 and TIMP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	matrix metallopeptidase 9	Homo sapiens	154-159
15333786-9	2004	Interfering with either signalling pathway via PI3K inhibitor LY294002 or MEK inhibitor U0126 in EGF-stimulated HTR8/SVneo cells blocked the induction of MMP-9 and TIMP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	TIMP metallopeptidase inhibitor 1	Homo sapiens	164-170
15333786-10	2004	LY294002 inhibited Akt phosphorylation, but had no effect on ERK phosphorylation; U0126 suppressed ERK phosphorylation without interfering with the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	19-22
15265705-6	2004	Either Ly294002 or PD98059, specific inhibitor of the PI3K and ERK/MAPK pathways, respectively, blocked the HGF-induced activation of SPK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	7-15	mitogen-activated protein kinase 1	Homo sapiens	63-66
15220345-10	2004	Expression of p85alpha and Akt mutants, or pretreatment of cells with LY294002, a PI3K inhibitor, attenuated sPLA(2)-induced MMP-2 activation and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	phospholipase A2 group X	Homo sapiens	109-115
15220345-10	2004	Expression of p85alpha and Akt mutants, or pretreatment of cells with LY294002, a PI3K inhibitor, attenuated sPLA(2)-induced MMP-2 activation and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	matrix metallopeptidase 2	Homo sapiens	125-130
15197768-9	2004	Selective inhibition of ERK/MAPK (by PD98059 or U0126) and PI3K (by LY294002 or wortmannin) led to marked reduction of both basal and BTC-induced MMP-9 activity and invasive ability of HNSCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	matrix metallopeptidase 9	Homo sapiens	146-151
15265705-6	2004	Either Ly294002 or PD98059, specific inhibitor of the PI3K and ERK/MAPK pathways, respectively, blocked the HGF-induced activation of SPK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	7-15	hepatocyte growth factor	Homo sapiens	108-111
15265705-6	2004	Either Ly294002 or PD98059, specific inhibitor of the PI3K and ERK/MAPK pathways, respectively, blocked the HGF-induced activation of SPK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	7-15	PDZ binding kinase	Homo sapiens	134-137
15177934-8	2004	The effects of NT on EGFR/ERK/Akt activation and DNA synthesis were attenuated by PLC-inhibitor (U73122), PKC-inhibitors (bisindolylmaleimide, staurosporine, rottlerin), MEK inhibitor (U0126) and PI3 kinase inhibitors (wortmannin, LY 294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	231-240	epidermal growth factor receptor	Homo sapiens	21-25
15177934-8	2004	The effects of NT on EGFR/ERK/Akt activation and DNA synthesis were attenuated by PLC-inhibitor (U73122), PKC-inhibitors (bisindolylmaleimide, staurosporine, rottlerin), MEK inhibitor (U0126) and PI3 kinase inhibitors (wortmannin, LY 294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	231-240	mitogen-activated protein kinase 1	Homo sapiens	26-29
15187085-3	2004	We determined the roles of the phosphatidylinositol (PI) 3-kinase and mitogen-activated protein (MAP) kinase-dependent pathways in the effect of mediating insulin on SREBP-1 in L-6 skeletal muscle cells and 3T3 L1 adipocytes, using wortmannin or LY294002 to inhibit the PI 3-kinase pathway, and PD98059 to inhibit the MAP kinase-dependent pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-254	insulin	Homo sapiens	155-162
15187085-5	2004	1 and 10 nm insulin significantly increased expression of total cellular SREBP-1 protein at 24 and 48 h, nuclear SREBP-1 protein at 24 h, and SREBP-1a mRNA at 24 h. Although wortmannin and LY294002 had no effect on this aspect of insulin action, PD98059 completely blocked each of these responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	insulin	Homo sapiens	12-19
15169778-4	2004	Stimulation of human embryonic kidney 293 cells with insulin-like growth factor-1 increased Mdm2 phosphorylation on Ser(166) and Ser(188) in a phosphatidylinositide 3"-OH kinase-dependent manner, and the treatment of both human embryonic kidney 293 and COS-1 cells with phosphatidylinositide 3"-OH kinase inhibitor LY-294002 led to proteasome-mediated Mdm2 degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	315-324	insulin like growth factor 1	Homo sapiens	53-81
15169778-4	2004	Stimulation of human embryonic kidney 293 cells with insulin-like growth factor-1 increased Mdm2 phosphorylation on Ser(166) and Ser(188) in a phosphatidylinositide 3"-OH kinase-dependent manner, and the treatment of both human embryonic kidney 293 and COS-1 cells with phosphatidylinositide 3"-OH kinase inhibitor LY-294002 led to proteasome-mediated Mdm2 degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	315-324	MDM2 proto-oncogene	Homo sapiens	92-96
15304336-5	2004	GH-mediated induction of adiponectin gene expression was completely blocked by treatment with the Janus kinase2 (JAK2) inhibitor AG490 and the P38 mitogen activated protein (MAP) kinase inhibitor SB203580, while the specific inhibitors of phosphatidylinositol-3-kinase (LY294002) and p70S6 kinase (rapamycin) moderately enhanced GHs effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	270-278	growth hormone 1	Homo sapiens	0-2
15187095-5	2004	Preincubation with the phosphoinositide 3"-kinase inhibitor LY294002 significantly reduced the effects of IGF-I on 14-3-3sigma gene expression in these cells, suggesting that this effect of IGF-I occurs via the phosphoinositide 3"-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	insulin like growth factor 1	Homo sapiens	106-111
15187095-5	2004	Preincubation with the phosphoinositide 3"-kinase inhibitor LY294002 significantly reduced the effects of IGF-I on 14-3-3sigma gene expression in these cells, suggesting that this effect of IGF-I occurs via the phosphoinositide 3"-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	stratifin	Homo sapiens	115-126
15187095-5	2004	Preincubation with the phosphoinositide 3"-kinase inhibitor LY294002 significantly reduced the effects of IGF-I on 14-3-3sigma gene expression in these cells, suggesting that this effect of IGF-I occurs via the phosphoinositide 3"-kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	insulin like growth factor 1	Homo sapiens	190-195
15304336-5	2004	GH-mediated induction of adiponectin gene expression was completely blocked by treatment with the Janus kinase2 (JAK2) inhibitor AG490 and the P38 mitogen activated protein (MAP) kinase inhibitor SB203580, while the specific inhibitors of phosphatidylinositol-3-kinase (LY294002) and p70S6 kinase (rapamycin) moderately enhanced GHs effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	270-278	adiponectin, C1Q and collagen domain containing	Homo sapiens	25-36
15249422-10	2004	The phosphorylation of Akt in response to RWPCs was abolished by wortmannin and LY294002, and by the membrane-permeant analogue of superoxide dismutase Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	AKT serine/threonine kinase 1	Homo sapiens	23-26
15208659-5	2004	LY294002, a PI3K inhibitor, blocked the activation of Akt and p70S6K, indicating that Akt and p70S6K activation is linked to PI3K activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	54-57
15208659-5	2004	LY294002, a PI3K inhibitor, blocked the activation of Akt and p70S6K, indicating that Akt and p70S6K activation is linked to PI3K activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribosomal protein S6 kinase B1	Homo sapiens	62-68
15208659-5	2004	LY294002, a PI3K inhibitor, blocked the activation of Akt and p70S6K, indicating that Akt and p70S6K activation is linked to PI3K activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	86-89
15208659-5	2004	LY294002, a PI3K inhibitor, blocked the activation of Akt and p70S6K, indicating that Akt and p70S6K activation is linked to PI3K activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribosomal protein S6 kinase B1	Homo sapiens	94-100
15208659-8	2004	LY294002 and rapamycin also blocked the enhancement of Egr-1 level, Cdk5 activity, and myogenin expression, suggesting that upregulation of these factors is coupled to PI3K-p70S6K activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	early growth response 1	Homo sapiens	55-60
15208659-8	2004	LY294002 and rapamycin also blocked the enhancement of Egr-1 level, Cdk5 activity, and myogenin expression, suggesting that upregulation of these factors is coupled to PI3K-p70S6K activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin dependent kinase 5	Homo sapiens	68-72
15208659-8	2004	LY294002 and rapamycin also blocked the enhancement of Egr-1 level, Cdk5 activity, and myogenin expression, suggesting that upregulation of these factors is coupled to PI3K-p70S6K activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	myogenin	Homo sapiens	87-95
15208659-8	2004	LY294002 and rapamycin also blocked the enhancement of Egr-1 level, Cdk5 activity, and myogenin expression, suggesting that upregulation of these factors is coupled to PI3K-p70S6K activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribosomal protein S6 kinase B1	Homo sapiens	173-179
15044179-7	2004	Pretreatment of hepatocytes with the PI3-kinase inhibitor, Ly-294002, prevented CPT-2-Me-cAMP"s protective effect against bile acid and Fas ligand, but not TNF-alpha-mediated apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	Fas ligand	Rattus norvegicus	136-146
15289335-6	2004	Both inhibition of the Ras-Raf-MEK (mitogen-activated protein/ERK kinase)-ERK cascade by either stable expression of dominant-negative H-Ras(N17) or addition of the MEK1 inhibitor PD98059 as well as inhibition of the phosphatidylinositol 3-kinase pathway by LY294002 prevented GDNF-induced migration and invasion of PANC-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	258-266	zinc fingers and homeoboxes 2	Homo sapiens	27-30
15174091-4	2004	Furthermore, the selective phosphoinositide 3-kinase (PI 3-kinase) inhibitors wortmannin and LY 294002 abrogated FAK phosphorylation at Tyr-397 but did not interfere with PDGF-induced FAK phosphorylation at Ser-910.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-102	PTK2 protein tyrosine kinase 2	Mus musculus	113-116
15316530-9	2004	The combination of PD98059 and Raf1 kinase inhibitor I completely blocked GM-CSF production, whereas 2 protein kinase C inhibitors, Ro-31-7549 and GF109203X, and a phosphatidylinositol 3-kinase inhibitor, LY294002, showed no inhibitory effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	31-35
15277479-8	2004	Inhibition of EGFR, ERK1/2, and PI3K activities with kinase-specific inhibitors (AG1478, U0126, and LY294002, respectively) resulted in an increase in the number of apoptotic cells, in elevated cellular caspase-3 activity, and/or in increased cleaved PARP in P. aeruginosa-infected HUCL cells or primary culture of HCECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	epidermal growth factor receptor	Homo sapiens	14-18
15291750-5	2004	The protective effect of IGF-I was blocked by phosphoinositide 3-kinase (PI3-kinase) inhibitor, LY294002, but was unaffected by PD98059, which inhibits MAP/ERK kinase (MEK1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	insulin-like growth factor 1	Rattus norvegicus	25-30
15287886-8	2004	AMPA-mediated neuroprotection is blocked by PP1, an inhibitor of src family kinases, LY294002, a PI3-K inhibitor, or U0126, a MAPK kinase (MEK) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	neuropeptide Y receptor Y4	Homo sapiens	44-47
15370202-4	2004	Inhibition of PI3-kinase with specific inhibitor, LY294002, led to the induction of apoptosis that was caspase 8 dependent, but independent of Akt as LY294002 did not depress a high basal level of Akt activity found in CLL cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	caspase 8	Homo sapiens	103-112
15370202-4	2004	Inhibition of PI3-kinase with specific inhibitor, LY294002, led to the induction of apoptosis that was caspase 8 dependent, but independent of Akt as LY294002 did not depress a high basal level of Akt activity found in CLL cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	143-146
15370202-4	2004	Inhibition of PI3-kinase with specific inhibitor, LY294002, led to the induction of apoptosis that was caspase 8 dependent, but independent of Akt as LY294002 did not depress a high basal level of Akt activity found in CLL cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	197-200
15370202-8	2004	GSK-3beta a kinase regulated via PI3-kinase dependent, down-stream kinases, was responsible for regulating cyclin D1 levels in CLL cells, but neither GSK-3beta nor calpain was responsible for induction of apoptosis, or activation of executioner caspase 3, following LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	266-274	glycogen synthase kinase 3 beta	Homo sapiens	0-9
15300175-9	2004	On Western blot, 200 micromol/L GCDA caused a 3-fold increase in Akt phosphorylation within 20 minutes, which was inhibited by 90% with the addition of PI3 kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	AKT serine/threonine kinase 1	Homo sapiens	65-68
15363324-11	2004	When treated with LY294002 or U0126 for 24 hours, the amount of wild p53 protein in MCF7-neu3 cells was 1.7 or 1.5 times higher than those in DMSO treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	tumor protein p53	Homo sapiens	69-72
15363324-12	2004	There were 4.7 or 5.3 times increase in the p53 protein when MCF7-neu3 cells were treated with LY294002 or U0126 for 48 hours (P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	tumor protein p53	Homo sapiens	44-47
15173165-6	2004	Biological activities of IL-1 beta were further determined; IL-1 beta altered the shape of CECs from polygonal to fibroblastic morphologies in a time- and dose-dependent manner, whereas neutralizing IL-1 beta antibody, neutralizing antibody to FGF-2, and LY294002 blocked the action of IL-1 beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	255-263	interleukin 1 beta	Homo sapiens	25-34
15208673-6	2004	Pretreatment of SKOV3 cells, which exhibit constitutive AKT activity under low serum conditions, with the PI3K inhibitor LY294002 augmented cisplatin-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	AKT serine/threonine kinase 1	Homo sapiens	56-59
15184909-7	2004	Functional correlation between Akt activation and the activation of NFkappaB was confirmed in U251MG GBM cells in which inhibition of Akt activation either by stable expression of PTEN or by the PI3-kinase inhibitors, wortmannin and LY294002, led to a concomitant decrease in NFkappaB-binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	AKT serine/threonine kinase 1	Homo sapiens	31-34
15184909-7	2004	Functional correlation between Akt activation and the activation of NFkappaB was confirmed in U251MG GBM cells in which inhibition of Akt activation either by stable expression of PTEN or by the PI3-kinase inhibitors, wortmannin and LY294002, led to a concomitant decrease in NFkappaB-binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	nuclear factor kappa B subunit 1	Homo sapiens	68-76
15184909-7	2004	Functional correlation between Akt activation and the activation of NFkappaB was confirmed in U251MG GBM cells in which inhibition of Akt activation either by stable expression of PTEN or by the PI3-kinase inhibitors, wortmannin and LY294002, led to a concomitant decrease in NFkappaB-binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	233-241	AKT serine/threonine kinase 1	Homo sapiens	134-137
15173165-10	2004	This early and rapid activation of PI 3-kinase greatly enhanced FGF-2 production in CECs; pretreatment with LY294002 hampered the induction activity of IL-1 beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	interleukin 1 beta	Homo sapiens	152-161
15240151-8	2004	Specifically, IL-1beta-induced nuclear translocation of NF-kappaB was in part attenuated by LY294002, but not by GF109203X, SB203580, and SP600125, suggesting PI3K-dependent nuclear translocation of NF-kappaB in response to IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	interleukin 1 beta	Homo sapiens	14-22
15240151-8	2004	Specifically, IL-1beta-induced nuclear translocation of NF-kappaB was in part attenuated by LY294002, but not by GF109203X, SB203580, and SP600125, suggesting PI3K-dependent nuclear translocation of NF-kappaB in response to IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	nuclear factor kappa B subunit 1	Homo sapiens	56-65
15240151-8	2004	Specifically, IL-1beta-induced nuclear translocation of NF-kappaB was in part attenuated by LY294002, but not by GF109203X, SB203580, and SP600125, suggesting PI3K-dependent nuclear translocation of NF-kappaB in response to IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	nuclear factor kappa B subunit 1	Homo sapiens	199-208
15240151-8	2004	Specifically, IL-1beta-induced nuclear translocation of NF-kappaB was in part attenuated by LY294002, but not by GF109203X, SB203580, and SP600125, suggesting PI3K-dependent nuclear translocation of NF-kappaB in response to IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	interleukin 1 beta	Homo sapiens	224-232
15084602-5	2004	In contrast, LY294002, an inhibitor of phosphatidylinositol 3-kinase (a pathway controlling initiation of the myogenic program) that inhibited both myogenin/MEF2 expression and fusion, did not affect Kir2.1 current.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	myogenin	Homo sapiens	148-156
15212942-5	2004	The survival effect of NGF was inhibited by inhibitors of protein kinase C (PKC), phosphatidylinositol-3-kinase (PI 3-kinase), and the mitogen-activated protein kinase kinase (MEK) inhibitors GF109203X, LY294002, and U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	nerve growth factor	Rattus norvegicus	23-26
15193993-5	2004	Only NSCC-1 was activated by ET-1 in wortmannin- or LY 294002-pretreated VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-61	endothelin-1	Oryctolagus cuniculus	29-33
15254091-7	2004	Two structurally unrelated PI3K inhibitors, LY294002 and wortmannin, blocked the DHPG-induced increases in phosphorylation of Akt and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	126-129
15254091-7	2004	Two structurally unrelated PI3K inhibitors, LY294002 and wortmannin, blocked the DHPG-induced increases in phosphorylation of Akt and mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	mechanistic target of rapamycin kinase	Homo sapiens	134-138
15084602-5	2004	In contrast, LY294002, an inhibitor of phosphatidylinositol 3-kinase (a pathway controlling initiation of the myogenic program) that inhibited both myogenin/MEF2 expression and fusion, did not affect Kir2.1 current.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	myocyte enhancer factor 2A	Homo sapiens	157-161
15084602-6	2004	This non-blockade by LY294002 indicates that Kir2.1 acts upstream of myogenin and MEF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	45-51
15084602-6	2004	This non-blockade by LY294002 indicates that Kir2.1 acts upstream of myogenin and MEF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	myogenin	Homo sapiens	69-77
15226309-3	2004	Forced expression of Runx2 enhanced osteoblastic differentiation of C3H10T1/2 and MC3T3-E1 cells and enhanced chondrogenic differentiation of ATDC5 cells, whereas these effects were blocked by treatment with IGF-I antibody or LY294002 or adenoviral introduction of dominant-negative (dn)-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	226-234	runt related transcription factor 2	Mus musculus	21-26
15177184-6	2004	The protein kinase activity of ATM was selectively inhibited by wortmannin, caffeine and LY294002 and was stimulated by charged biological polymers, including single-stranded M13 DNA (ssDNA), sheared double-stranded calf thymus DNA, heparin sulfate and poly ADP-ribose (PAR), raising the possibility that charged structures may contribute to regulation of ATM activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	ATM serine/threonine kinase	Bos taurus	31-34
15226309-4	2004	Forced expression of Runx2 or dn-Runx2 enhanced or inhibited cell migration, respectively, whereas the enhancement by Runx2 was abolished by treatment with LY294002 or adenoviral introduction of dn-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	runt related transcription factor 2	Mus musculus	21-26
15226309-6	2004	Treatment with LY294002 or introduction of dn-Akt severely diminished DNA binding of Runx2 and Runx2-dependent transcription, whereas forced expression of myrAkt enhanced them.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	runt related transcription factor 2	Mus musculus	85-90
15226309-6	2004	Treatment with LY294002 or introduction of dn-Akt severely diminished DNA binding of Runx2 and Runx2-dependent transcription, whereas forced expression of myrAkt enhanced them.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	runt related transcription factor 2	Mus musculus	95-100
15028625-9	2004	Finally, inhibition of FSH-stimulated glucose uptake by the PI3-kinase inhibitor LY294002 and the finding of GLUT4 protein in granulosa cells suggest that FSH increases glucose uptake by PI3-kinase-mediated translocation of GLUT4 to the granulosa cell membrane.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	follicle stimulating hormone beta	Mus musculus	23-26
15020298-7	2004	In contrast to its extensively documented antiapoptotic effect, the elevated activity of Akt appears to be important in sensitizing caveolin-1-expressing cells to TNF-alpha, since pretreatment of cells with the phosphatidylinositide 3-kinase (PI3K) inhibitor LY-294002 or wortmannin completely blocked PI3K activation and markedly improved the survival of TNF-alpha-treated L929 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	259-268	thymoma viral proto-oncogene 1	Mus musculus	89-92
15020298-7	2004	In contrast to its extensively documented antiapoptotic effect, the elevated activity of Akt appears to be important in sensitizing caveolin-1-expressing cells to TNF-alpha, since pretreatment of cells with the phosphatidylinositide 3-kinase (PI3K) inhibitor LY-294002 or wortmannin completely blocked PI3K activation and markedly improved the survival of TNF-alpha-treated L929 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	259-268	caveolin 1, caveolae protein	Mus musculus	132-142
15020298-7	2004	In contrast to its extensively documented antiapoptotic effect, the elevated activity of Akt appears to be important in sensitizing caveolin-1-expressing cells to TNF-alpha, since pretreatment of cells with the phosphatidylinositide 3-kinase (PI3K) inhibitor LY-294002 or wortmannin completely blocked PI3K activation and markedly improved the survival of TNF-alpha-treated L929 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	259-268	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	211-241
15487702-6	2004	Similar experiments were performed using LY294002 and U0126, specific inhibitors of PI3 kinase and MEK, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	midkine	Mus musculus	99-102
15224190-4	2004	On the other hand, repression of PI3K by LY294002 induces p300 degradation through the 26S proteasome pathway and impedes the transcriptional activity of the coactivator.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	E1A binding protein p300	Homo sapiens	58-62
15115658-4	2004	The phosphorylation of Akt was blocked by pretreatment with LY294002, a PI-3-kinase inhibitor, in both Rat1/NHERF2 and Rat1/vector cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
15115658-4	2004	The phosphorylation of Akt was blocked by pretreatment with LY294002, a PI-3-kinase inhibitor, in both Rat1/NHERF2 and Rat1/vector cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	SLC9A3 regulator 2	Rattus norvegicus	108-114
15115658-9	2004	Consistent with these results, the PDGF-induced thymidine incorporation was increased in Rat1/NHERF2 cells, and the NHERF2-dependent increase of thymidine incorporation was prevented by treatment with LY294002 and PP2 but not with PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	SLC9A3 regulator 2	Rattus norvegicus	94-100
15115658-9	2004	Consistent with these results, the PDGF-induced thymidine incorporation was increased in Rat1/NHERF2 cells, and the NHERF2-dependent increase of thymidine incorporation was prevented by treatment with LY294002 and PP2 but not with PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	201-209	SLC9A3 regulator 2	Rattus norvegicus	116-122
15194439-6	2004	In contrast, inhibition of PI3K with LY294002 abolished the FGF-2-induced inhibition of caspases-2 and -3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	fibroblast growth factor 2	Homo sapiens	60-65
15357004-10	2004	LY294002 a Pl3-kinase inhibitor blocked GSTA2 induction by t-BHQ, which was reversed by PMA-induced PKC activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glutathione S-transferase alpha 2	Homo sapiens	40-45
15194439-6	2004	In contrast, inhibition of PI3K with LY294002 abolished the FGF-2-induced inhibition of caspases-2 and -3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	caspase 2	Homo sapiens	88-105
15183100-7	2004	Furthermore, EGF-induced protection was substantially reduced by either the PI3K inhibitor LY294002 (25 microm) or the MEK inhibitor U0126 (10 microm), under conditions in which phosphorylation of Akt and ERK1/2, respectively, was blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	epidermal growth factor	Homo sapiens	13-16
15194442-7	2004	Both adenovirus-mediated expression of dominant-negative Akt and inhibition of PI3 kinase-mediated Akt activation with LY294002 blocked cell cycle progression of low-density cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	peptidase inhibitor 3	Homo sapiens	79-82
15194442-7	2004	Both adenovirus-mediated expression of dominant-negative Akt and inhibition of PI3 kinase-mediated Akt activation with LY294002 blocked cell cycle progression of low-density cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Homo sapiens	99-102
15211574-6	2004	LY294002, an inhibitor of PI3K, blocked the basal and TGF-beta1-enhanced cell migration but not adhesion to betaig-h3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transforming growth factor beta 1	Homo sapiens	54-63
15492414-5	2004	The PI3 kinase inhibitor LY294002 reduced COX-2 expression in HSC-5 cells and, contrary to our expectation, the phosphorylation of Akt was significantly decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
15492414-5	2004	The PI3 kinase inhibitor LY294002 reduced COX-2 expression in HSC-5 cells and, contrary to our expectation, the phosphorylation of Akt was significantly decreased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	131-134
15252145-8	2004	A similar augmentation of JNK phosphorylation was observed on treatment with a PI3K inhibitor, LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-104	mitogen-activated protein kinase 8	Homo sapiens	26-29
15107457-7	2004	Furthermore, activation of Rac was attenuated by pretreatment of neutrophils with the phosphatidylinositol 3-kinase (PI-3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	AKT serine/threonine kinase 1	Homo sapiens	27-30
15107457-7	2004	Furthermore, activation of Rac was attenuated by pretreatment of neutrophils with the phosphatidylinositol 3-kinase (PI-3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	86-115
15082710-13	2004	Ly294002 or a dominant negative PI 3-kinase significantly blocked IFN-gamma-induced MAPK activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interferon gamma	Homo sapiens	66-75
15280449-8	2004	The phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, reduces Plk1 dephosphorylation following mitotic DNA damaging treatments, suggesting that the PI3K pathway may be involved in regulating Plk1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	polo like kinase 1	Homo sapiens	70-74
15280449-8	2004	The phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, reduces Plk1 dephosphorylation following mitotic DNA damaging treatments, suggesting that the PI3K pathway may be involved in regulating Plk1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	polo like kinase 1	Homo sapiens	199-203
15213856-7	2004	MnCl(2)-induced alpha V beta 3 clustering was blocked by a soluble RGD peptide, by wortmannin and LY294002, two pharmacological inhibitors of phosphatidylinositol 3-kinase (PI 3-K), and by over-expressing a dominant negative PI 3-K mutant protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	24-30
15082710-8	2004	Ly294002, a pharmacological inhibitor of phosphatidylinositol (PI) 3-kinase, blocked IFN-gamma-induced PKCepsilon activity and resulted in inhibition of STAT1alpha transcriptional activity but had no effect on STAT1alpha tyrosine phosphorylation and STAT1alpha-DNA complex formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interferon gamma	Homo sapiens	85-94
15082710-8	2004	Ly294002, a pharmacological inhibitor of phosphatidylinositol (PI) 3-kinase, blocked IFN-gamma-induced PKCepsilon activity and resulted in inhibition of STAT1alpha transcriptional activity but had no effect on STAT1alpha tyrosine phosphorylation and STAT1alpha-DNA complex formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein kinase C epsilon	Homo sapiens	103-113
15082710-10	2004	However, Ly294002 and H7 blocked IFN-gamma-induced serine phosphorylation of STAT1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	interferon gamma	Homo sapiens	33-42
15279711-9	2004	Similarly, treatment with the phosphatidylinositol 3-kinase inhibitor LY294002 prevented the induction of MT1-MMP protein by EGF stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	matrix metallopeptidase 14	Homo sapiens	106-113
15279711-9	2004	Similarly, treatment with the phosphatidylinositol 3-kinase inhibitor LY294002 prevented the induction of MT1-MMP protein by EGF stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	epidermal growth factor	Homo sapiens	125-128
15347471-6	2004	Inhibitory effect of LY294002 on activation of PKB induced by 17beta-E(2) was also studied.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	protein tyrosine kinase 2 beta	Homo sapiens	47-50
15347471-11	2004	PI3K inhibitor, LY294002 could inhibit the activation of PKB induced by 17beta-E(2) in Ishikawa cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	protein tyrosine kinase 2 beta	Homo sapiens	57-60
15347471-12	2004	Levels of PKB (p-PKB/PKB) decreased (0.443 +/- 0.032, 0.415 +/- 0.032, 0.111 +/- 0.035, 0, 0) gradually with increased concentrations (vehicle, 0.1, 10, 50, 100 micro mol/L) of LY294002 (compared with vehicle, P &gt; 0.05, &lt; 0.05, &lt; 0.001, &lt; 0.001) and 50 micro mol/L LY294002 completely blocked the activation of PKB induced by 17beta-E(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	protein tyrosine kinase 2 beta	Homo sapiens	10-13
15347471-12	2004	Levels of PKB (p-PKB/PKB) decreased (0.443 +/- 0.032, 0.415 +/- 0.032, 0.111 +/- 0.035, 0, 0) gradually with increased concentrations (vehicle, 0.1, 10, 50, 100 micro mol/L) of LY294002 (compared with vehicle, P &gt; 0.05, &lt; 0.05, &lt; 0.001, &lt; 0.001) and 50 micro mol/L LY294002 completely blocked the activation of PKB induced by 17beta-E(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	aquaporin 5	Homo sapiens	15-20
15347471-12	2004	Levels of PKB (p-PKB/PKB) decreased (0.443 +/- 0.032, 0.415 +/- 0.032, 0.111 +/- 0.035, 0, 0) gradually with increased concentrations (vehicle, 0.1, 10, 50, 100 micro mol/L) of LY294002 (compared with vehicle, P &gt; 0.05, &lt; 0.05, &lt; 0.001, &lt; 0.001) and 50 micro mol/L LY294002 completely blocked the activation of PKB induced by 17beta-E(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	protein tyrosine kinase 2 beta	Homo sapiens	17-20
15347471-12	2004	Levels of PKB (p-PKB/PKB) decreased (0.443 +/- 0.032, 0.415 +/- 0.032, 0.111 +/- 0.035, 0, 0) gradually with increased concentrations (vehicle, 0.1, 10, 50, 100 micro mol/L) of LY294002 (compared with vehicle, P &gt; 0.05, &lt; 0.05, &lt; 0.001, &lt; 0.001) and 50 micro mol/L LY294002 completely blocked the activation of PKB induced by 17beta-E(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	protein tyrosine kinase 2 beta	Homo sapiens	17-20
15347471-12	2004	Levels of PKB (p-PKB/PKB) decreased (0.443 +/- 0.032, 0.415 +/- 0.032, 0.111 +/- 0.035, 0, 0) gradually with increased concentrations (vehicle, 0.1, 10, 50, 100 micro mol/L) of LY294002 (compared with vehicle, P &gt; 0.05, &lt; 0.05, &lt; 0.001, &lt; 0.001) and 50 micro mol/L LY294002 completely blocked the activation of PKB induced by 17beta-E(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	protein tyrosine kinase 2 beta	Homo sapiens	10-13
15347471-12	2004	Levels of PKB (p-PKB/PKB) decreased (0.443 +/- 0.032, 0.415 +/- 0.032, 0.111 +/- 0.035, 0, 0) gradually with increased concentrations (vehicle, 0.1, 10, 50, 100 micro mol/L) of LY294002 (compared with vehicle, P &gt; 0.05, &lt; 0.05, &lt; 0.001, &lt; 0.001) and 50 micro mol/L LY294002 completely blocked the activation of PKB induced by 17beta-E(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	aquaporin 5	Homo sapiens	15-20
15347471-12	2004	Levels of PKB (p-PKB/PKB) decreased (0.443 +/- 0.032, 0.415 +/- 0.032, 0.111 +/- 0.035, 0, 0) gradually with increased concentrations (vehicle, 0.1, 10, 50, 100 micro mol/L) of LY294002 (compared with vehicle, P &gt; 0.05, &lt; 0.05, &lt; 0.001, &lt; 0.001) and 50 micro mol/L LY294002 completely blocked the activation of PKB induced by 17beta-E(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	protein tyrosine kinase 2 beta	Homo sapiens	17-20
15347471-12	2004	Levels of PKB (p-PKB/PKB) decreased (0.443 +/- 0.032, 0.415 +/- 0.032, 0.111 +/- 0.035, 0, 0) gradually with increased concentrations (vehicle, 0.1, 10, 50, 100 micro mol/L) of LY294002 (compared with vehicle, P &gt; 0.05, &lt; 0.05, &lt; 0.001, &lt; 0.001) and 50 micro mol/L LY294002 completely blocked the activation of PKB induced by 17beta-E(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	protein tyrosine kinase 2 beta	Homo sapiens	17-20
15044465-7	2004	TGF-beta-induced motility was blocked by coincubation with either the phosphatidylinositol 3-kinase inhibitor LY294002, the mitogen-activated protein kinase (MAPK) inhibitor U0126, the p38 MAPK inhibitor SB202190, and an integrin beta(1) blocking antibody.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	transforming growth factor beta 1	Homo sapiens	0-8
15187100-6	2004	Suppression of PI3-kinase activation by dexamethasone may also contribute to reduced cytokine production because the PI3-kinase inhibitor LY294002, like dexamethasone, inhibits Ag-induced transcription of cytokine genes as well as degranulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	WAP four-disulfide core domain 15B	Rattus norvegicus	15-18
15187100-6	2004	Suppression of PI3-kinase activation by dexamethasone may also contribute to reduced cytokine production because the PI3-kinase inhibitor LY294002, like dexamethasone, inhibits Ag-induced transcription of cytokine genes as well as degranulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	WAP four-disulfide core domain 15B	Rattus norvegicus	117-120
15048073-4	2004	Either pretreatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, or transfection with a dominant-negative Akt attenuated the E(2)-induced activation of the hTERT promoter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	telomerase reverse transcriptase	Homo sapiens	176-181
15147956-5	2004	Phosphorylation of AKT and FoxO3 was blocked by the PI-3 kinase inhibitor LY294002 but not by the MAP kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	thymoma viral proto-oncogene 1	Mus musculus	19-22
15147956-5	2004	Phosphorylation of AKT and FoxO3 was blocked by the PI-3 kinase inhibitor LY294002 but not by the MAP kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	forkhead box O3	Mus musculus	27-32
15140644-7	2004	Phosphorylation of Akt was blocked with selective inhibitors (wortmannin and LY294002), which implicates phosphoinositide 3-kinase (PI3K) in the signaling cascade.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
15077177-7	2004	Furthermore, specific inhibition of phosphotidylinositol-3 kinase (PI-3K) with LY294002 reverted the radioresistant phenotype in the immortalized astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	36-65
15144893-0	2004	LY294002 inhibits interferon-gamma-stimulated inducible nitric oxide synthase expression in BV2 microglial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interferon gamma	Mus musculus	18-34
15056668-3	2004	Pharmacological inhibition of PI3K activity by Ly294002 disrupted IFN-induced apoptosis upstream of mitochondria.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	interferon alpha 1	Homo sapiens	66-69
15056668-5	2004	A PI3K and mTOR-dependent phosphorylation of p70S6 kinase and 4E-BP1 repressor was induced by IFNalpha treatment of cells and was strongly inhibited by Ly294002 or rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	mechanistic target of rapamycin kinase	Homo sapiens	11-15
15056668-5	2004	A PI3K and mTOR-dependent phosphorylation of p70S6 kinase and 4E-BP1 repressor was induced by IFNalpha treatment of cells and was strongly inhibited by Ly294002 or rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	interferon alpha 1	Homo sapiens	94-102
15144893-2	2004	We found that LY294002, a PI3K inhibitor, markedly reduced IFN-gamma-induced morphological changes, NO production, and cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	interferon gamma	Mus musculus	59-68
15144893-3	2004	The inhibitory effect of LY294002 on NO generation may be mediated through specific inhibition of signal transducer and activator-1 (STAT1) and NF-kappaB, which are activated by IFN-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	signal transducer and activator of transcription 1	Mus musculus	98-131
15144893-3	2004	The inhibitory effect of LY294002 on NO generation may be mediated through specific inhibition of signal transducer and activator-1 (STAT1) and NF-kappaB, which are activated by IFN-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	signal transducer and activator of transcription 1	Mus musculus	133-138
15144893-3	2004	The inhibitory effect of LY294002 on NO generation may be mediated through specific inhibition of signal transducer and activator-1 (STAT1) and NF-kappaB, which are activated by IFN-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	144-153
15144893-3	2004	The inhibitory effect of LY294002 on NO generation may be mediated through specific inhibition of signal transducer and activator-1 (STAT1) and NF-kappaB, which are activated by IFN-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	interferon gamma	Mus musculus	178-187
15095290-11	2004	LY294002, another PI 3-kinase inhibitor, likewise blocked the insulin-stimulated activity of the exchanger.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin	Homo sapiens	62-69
15161854-6	2004	Ly294002, a specific inhibitor of PI3K, resulted in time- and dose-dependent blockade of MCP-1 mRNA expression and protein production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-C motif chemokine ligand 2	Homo sapiens	89-94
15161854-9	2004	Ly294002 as well as U0126, SB202190, and SP600125, the selective inhibitors of MEK, p38, and JNK, respectively, strongly inhibited induced c-fos expression, whereas Ly294002 did not inhibit induction of MEK, p38, or JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 14	Homo sapiens	84-87
15161854-9	2004	Ly294002 as well as U0126, SB202190, and SP600125, the selective inhibitors of MEK, p38, and JNK, respectively, strongly inhibited induced c-fos expression, whereas Ly294002 did not inhibit induction of MEK, p38, or JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 8	Homo sapiens	93-96
15161854-9	2004	Ly294002 as well as U0126, SB202190, and SP600125, the selective inhibitors of MEK, p38, and JNK, respectively, strongly inhibited induced c-fos expression, whereas Ly294002 did not inhibit induction of MEK, p38, or JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	139-144
15161854-9	2004	Ly294002 as well as U0126, SB202190, and SP600125, the selective inhibitors of MEK, p38, and JNK, respectively, strongly inhibited induced c-fos expression, whereas Ly294002 did not inhibit induction of MEK, p38, or JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 14	Homo sapiens	208-211
15161854-9	2004	Ly294002 as well as U0126, SB202190, and SP600125, the selective inhibitors of MEK, p38, and JNK, respectively, strongly inhibited induced c-fos expression, whereas Ly294002 did not inhibit induction of MEK, p38, or JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 8	Homo sapiens	216-219
14988390-7	2004	Pretreatment of the cells with phosphatidylinositol 3-kinase inhibitor LY294002 or wortmannin, which blocks androgen action in cells, abolished R1881-induced GSK-3beta Y(216) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	glycogen synthase kinase 3 beta	Homo sapiens	158-167
15161854-11	2004	CONCLUSIONS: The Ly294002-sensitive PI3K/Akt pathway regulates MCP-1, but not IL-8 expression in hRPE cells independent of MAPK and IkappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	thymoma viral proto-oncogene 1	Mus musculus	41-44
15161854-11	2004	CONCLUSIONS: The Ly294002-sensitive PI3K/Akt pathway regulates MCP-1, but not IL-8 expression in hRPE cells independent of MAPK and IkappaB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	chemokine (C-C motif) ligand 2	Mus musculus	63-68
14982949-7	2004	In contrast, phosphatidylinositol-3 kinase (PI-3K) inhibitors Wortmannin and LY294002 inhibited phagocytosis without affecting ERK phosphorylation or MIP-1alpha production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	13-42
15153523-8	2004	Like TGF-beta1, the PI3K inhibitor LY294002 blocked iNOS expression and death in cultured microglial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	transforming growth factor beta 1	Homo sapiens	5-14
15153523-8	2004	Like TGF-beta1, the PI3K inhibitor LY294002 blocked iNOS expression and death in cultured microglial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	nitric oxide synthase 2	Homo sapiens	52-56
15153536-4	2004	In normal fibroblasts, the PI3K inhibitor, LY294002, significantly decreased the basal and the TGF-beta1-induced increased stability of COL1A2 mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	transforming growth factor beta 1	Homo sapiens	95-104
15153523-9	2004	Both TGF-beta1 and LY294002 decreased the activation of caspases 3 and 11 and the mRNA expression of various kinds of inflammatory molecules caused by LPS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	caspase 3	Homo sapiens	56-73
15153536-4	2004	In normal fibroblasts, the PI3K inhibitor, LY294002, significantly decreased the basal and the TGF-beta1-induced increased stability of COL1A2 mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	collagen type I alpha 2 chain	Homo sapiens	136-142
15153536-5	2004	The TGF-beta1-induced COL1A2 promoter activity, but not the basal activity, was significantly attenuated by LY294002 or the dominant negative mutant of p85 subunit of PI3K, while the constitutive active mutant of p110 subunit of PI3K did not affect the basal or the TGF-beta1-induced COL1A2 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	transforming growth factor beta 1	Homo sapiens	4-13
15102045-3	2004	OBJECTIVES: The purpose of this study was to investigate the gelatinolytic activity in human osteosarcoma cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of SB203580 (p38 inhibitor), U0126 [mitogen-activated protein kinase kinase (MEK) inhibitor], and LY294002 [phosphatidylinositaol 3-kinase (PI3K) inhibitor].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	312-320	interleukin 1 alpha	Homo sapiens	128-146
15153536-5	2004	The TGF-beta1-induced COL1A2 promoter activity, but not the basal activity, was significantly attenuated by LY294002 or the dominant negative mutant of p85 subunit of PI3K, while the constitutive active mutant of p110 subunit of PI3K did not affect the basal or the TGF-beta1-induced COL1A2 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	collagen type I alpha 2 chain	Homo sapiens	22-28
15153536-5	2004	The TGF-beta1-induced COL1A2 promoter activity, but not the basal activity, was significantly attenuated by LY294002 or the dominant negative mutant of p85 subunit of PI3K, while the constitutive active mutant of p110 subunit of PI3K did not affect the basal or the TGF-beta1-induced COL1A2 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	transforming growth factor beta 1	Homo sapiens	266-275
15153536-5	2004	The TGF-beta1-induced COL1A2 promoter activity, but not the basal activity, was significantly attenuated by LY294002 or the dominant negative mutant of p85 subunit of PI3K, while the constitutive active mutant of p110 subunit of PI3K did not affect the basal or the TGF-beta1-induced COL1A2 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	collagen type I alpha 2 chain	Homo sapiens	284-290
15153536-6	2004	LY294002 significantly decreased the phosphorylation of Smad3 induced by TGF-beta1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	SMAD family member 3	Homo sapiens	56-61
15153536-6	2004	LY294002 significantly decreased the phosphorylation of Smad3 induced by TGF-beta1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transforming growth factor beta 1	Homo sapiens	73-82
15153536-7	2004	Furthermore, the transient overexpression of 2xFYVE, which induces the mislocalization of FYVE domain proteins, decreased the TGF-beta1-induced Smad3 phosphorylation to a similar extent to LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	transforming growth factor beta 1	Homo sapiens	126-135
15153536-9	2004	Furthermore, LY294002 and the transient overexpression of 2xFYVE completely diminished the constitutive phosphorylation of Smad3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	SMAD family member 3	Homo sapiens	123-128
15213361-8	2004	The effect of leptin on Na(+),K(+)-ATPase activity was abolished by actin depolymerizing agents, cytochalazin D and latrunculin B, and by phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	leptin	Rattus norvegicus	14-20
15147515-5	2004	Ser9-GSK3beta phosphorylation induced by HNE was abolished by treatment with LY294002 or U0126, two inhibitors of PI3K/AKT and ERK pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	glycogen synthase kinase 3 beta	Homo sapiens	5-13
15147515-5	2004	Ser9-GSK3beta phosphorylation induced by HNE was abolished by treatment with LY294002 or U0126, two inhibitors of PI3K/AKT and ERK pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	119-122
15147515-5	2004	Ser9-GSK3beta phosphorylation induced by HNE was abolished by treatment with LY294002 or U0126, two inhibitors of PI3K/AKT and ERK pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	mitogen-activated protein kinase 1	Homo sapiens	127-130
15102045-8	2004	In addition, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha or P. gingivalis-stimulated MMP-9 production, respectively (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	interleukin 1 alpha	Homo sapiens	69-78
15102045-8	2004	In addition, SB203580, U0126, and LY294002 significantly reduced the IL-1alpha or P. gingivalis-stimulated MMP-9 production, respectively (p &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	matrix metallopeptidase 9	Homo sapiens	107-112
15102045-11	2004	SB203580, U0126, and LY294002 suppress MMP-9 production and/or activity and may therefore be valuable therapeutics in MMP-mediated periodontal destruction, and might be proved clinically useful agents, in combination with standard treatment modalities, in the treatment of periodontitis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	matrix metallopeptidase 9	Homo sapiens	39-44
15102045-3	2004	OBJECTIVES: The purpose of this study was to investigate the gelatinolytic activity in human osteosarcoma cells stimulated with interleukin-1alpha (IL-1alpha) or Porphyromonas gingivalis in the absence or presence of SB203580 (p38 inhibitor), U0126 [mitogen-activated protein kinase kinase (MEK) inhibitor], and LY294002 [phosphatidylinositaol 3-kinase (PI3K) inhibitor].	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	312-320	interleukin 1 alpha	Homo sapiens	148-157
15266826-7	2004	Among the inhibitors of intracellular signaling transduction pathways, mitogen-activated protein kinases (MAPK) inhibitor PD98059 (40 micromol/L) and p38 MAPK inhibitor SB203580 (5 micromol/L) completely blocked the stimulatory effect of IL-1beta, and phosphoinositide 3-kinase (PI3-K) inhibitor LY294002 (10 micromol/L) partly blocked the induction of IL-1beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	296-304	mitogen activated protein kinase 14	Rattus norvegicus	150-153
15102045-11	2004	SB203580, U0126, and LY294002 suppress MMP-9 production and/or activity and may therefore be valuable therapeutics in MMP-mediated periodontal destruction, and might be proved clinically useful agents, in combination with standard treatment modalities, in the treatment of periodontitis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	matrix metallopeptidase 2	Homo sapiens	39-42
15161350-8	2004	The survival-enhancing effect of bFGF was abrogated by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	fibroblast growth factor 2	Homo sapiens	33-37
15085152-5	2004	Pretreatment with PI3-kinase inhibitors (wortmannin and LY294002) dose-dependently inhibited TPO-induced aggregation of CML-CP platelets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	thrombopoietin	Homo sapiens	93-96
15047866-5	2004	Blockade of the Akt/phosphoinositide 3-kinase (PI3-kinase) pathway with LY294002 and wortmannin prevents the ability of ET-1 to induce alpha-SMA, ezrin, paxillin, and moesin and to promote matrix contraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	16-19
15047866-5	2004	Blockade of the Akt/phosphoinositide 3-kinase (PI3-kinase) pathway with LY294002 and wortmannin prevents the ability of ET-1 to induce alpha-SMA, ezrin, paxillin, and moesin and to promote matrix contraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	endothelin 1	Homo sapiens	120-124
15047866-5	2004	Blockade of the Akt/phosphoinositide 3-kinase (PI3-kinase) pathway with LY294002 and wortmannin prevents the ability of ET-1 to induce alpha-SMA, ezrin, paxillin, and moesin and to promote matrix contraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	moesin	Homo sapiens	167-173
15169906-4	2004	Treatment of insulin-stimulated 3T3-L1 adipocytes with the PI 3-kinase inhibitor LY294002 causes the accumulation of GLUT4-containing vesicles just beneath the cell surface.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	insulin	Homo sapiens	13-20
15169906-4	2004	Treatment of insulin-stimulated 3T3-L1 adipocytes with the PI 3-kinase inhibitor LY294002 causes the accumulation of GLUT4-containing vesicles just beneath the cell surface.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	solute carrier family 2 member 4	Homo sapiens	117-122
15169906-6	2004	Remarkably, enhanced Myo1c expression under these conditions causes extensive membrane ruffling and overrides the block in membrane fusion caused by LY294002, restoring the display of GLUT4 on the cell exterior.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	myosin IC	Homo sapiens	21-26
14993225-7	2004	The acute lipid-lowering effect of leptin on livers from lean animals was mediated by a PI 3-kinase-dependent mechanism, because wortmannin and LY294002, the PI 3-kinase inhibitors, blocked the effects of leptin on hepatic triglyceride levels and leptin increased liver PI 3-kinase activity by 183 +/- 6% (p = 0.003) and insulin receptor substrate 1 tyrosine phosphorylation by 185 +/- 30% (p = 0.02) in the absence of PI 3-kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	leptin	Rattus norvegicus	35-41
15150102-9	2004	LY294002 inhibited AKT activation in BDC cells and, on irradiation, decreased clonogenic survival in a radiation dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	19-22
14999001-4	2004	The finding that LY294002 blocks MUC1-mediated increases in phospho-Akt and phospho-Bad supports the involvement of phosphoinositide 3-kinase (PI3K) as an upstream effector of this response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	mucin 1, cell surface associated	Rattus norvegicus	33-37
14999001-4	2004	The finding that LY294002 blocks MUC1-mediated increases in phospho-Akt and phospho-Bad supports the involvement of phosphoinositide 3-kinase (PI3K) as an upstream effector of this response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	AKT serine/threonine kinase 1	Rattus norvegicus	68-71
15047702-4	2004	The effects of LY294002 were more pronounced on the collagen alpha1(I) chain, which was inhibited at the transcriptional and mRNA stability levels versus collagen alpha2(I) chain, which was inhibited through a decrease in mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	LOC728145	Homo sapiens	52-76
15024023-7	2004	Inactivation of Akt by either treatment with LY294002 or ectopic expression of a dominant negative Akt mutant (DNMAkt) not only enhanced the caspase-3 activation in polyamine-deficient cells but also prevented the increased resistance to tumor necrosis factor-alpha/cycloheximide-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	16-19
15024023-8	2004	Phosphorylation of glycogen synthase kinase-3, a downstream target of Akt, was also increased in alpha-difluoromethylornithine-treated cells, which was prevented by inactivation of Akt by LY294002 or DNMAkt overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	AKT serine/threonine kinase 1	Homo sapiens	70-73
15024023-8	2004	Phosphorylation of glycogen synthase kinase-3, a downstream target of Akt, was also increased in alpha-difluoromethylornithine-treated cells, which was prevented by inactivation of Akt by LY294002 or DNMAkt overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	AKT serine/threonine kinase 1	Homo sapiens	181-184
14993225-7	2004	The acute lipid-lowering effect of leptin on livers from lean animals was mediated by a PI 3-kinase-dependent mechanism, because wortmannin and LY294002, the PI 3-kinase inhibitors, blocked the effects of leptin on hepatic triglyceride levels and leptin increased liver PI 3-kinase activity by 183 +/- 6% (p = 0.003) and insulin receptor substrate 1 tyrosine phosphorylation by 185 +/- 30% (p = 0.02) in the absence of PI 3-kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	leptin	Rattus norvegicus	205-211
14993225-7	2004	The acute lipid-lowering effect of leptin on livers from lean animals was mediated by a PI 3-kinase-dependent mechanism, because wortmannin and LY294002, the PI 3-kinase inhibitors, blocked the effects of leptin on hepatic triglyceride levels and leptin increased liver PI 3-kinase activity by 183 +/- 6% (p = 0.003) and insulin receptor substrate 1 tyrosine phosphorylation by 185 +/- 30% (p = 0.02) in the absence of PI 3-kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	leptin	Rattus norvegicus	205-211
14993225-7	2004	The acute lipid-lowering effect of leptin on livers from lean animals was mediated by a PI 3-kinase-dependent mechanism, because wortmannin and LY294002, the PI 3-kinase inhibitors, blocked the effects of leptin on hepatic triglyceride levels and leptin increased liver PI 3-kinase activity by 183 +/- 6% (p = 0.003) and insulin receptor substrate 1 tyrosine phosphorylation by 185 +/- 30% (p = 0.02) in the absence of PI 3-kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	insulin receptor substrate 1	Rattus norvegicus	321-349
15132824-5	2004	The stimulatory effect of Ang II on 4E-BP1 and p70 S6 kinase phosphorylation was abrogated by Ang II type 1 receptor (A(T1) receptor) antagonist losartan, and suppressed by PI3K inhibitor LY294002 in a concentration-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	angiotensinogen	Rattus norvegicus	26-32
14993222-6	2004	MMP-2 induction was blocked by the PI 3-kinase inhibitors LY294002 and wortmannin, by overexpression of a dominant-negative Akt or wild-type PTEN (phosphatase and tensin homologue deleted on chromosome 10), and by rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	matrix metallopeptidase 2	Mus musculus	0-5
14982927-6	2004	FSH-stimulated HIF-1 activity is inhibited by the PI 3-kinase inhibitor LY294002, the Rheb inhibitor FTI-277 (farnesyltransferase inhibitor-277), and the mTOR inhibitor rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-20
15132824-5	2004	The stimulatory effect of Ang II on 4E-BP1 and p70 S6 kinase phosphorylation was abrogated by Ang II type 1 receptor (A(T1) receptor) antagonist losartan, and suppressed by PI3K inhibitor LY294002 in a concentration-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	36-42
15132824-5	2004	The stimulatory effect of Ang II on 4E-BP1 and p70 S6 kinase phosphorylation was abrogated by Ang II type 1 receptor (A(T1) receptor) antagonist losartan, and suppressed by PI3K inhibitor LY294002 in a concentration-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	angiotensinogen	Rattus norvegicus	94-100
15146435-9	2004	The protein kinase C and phosphatidylinositol 3-kinase signal-transduction inhibitors bisindolylmaleimide I and LY294002, respectively, blocked BCP crystal-induced COX-2 mRNA in HFFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	prostaglandin-endoperoxide synthase 2	Homo sapiens	164-169
14693677-10	2004	Inhibition of PI3K, using the selective inhibitor LY-294002, and downregulation of SAM68, by antisense oligonucleotides, significantly decreased ANG II-stimulated incorporation of [3H]leucine and [3H]thymidine in VSMCs, showing the functional significance of PI3K and SAM68.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-59	angiotensinogen	Rattus norvegicus	145-151
15081899-2	2004	In this study, we found that LY294002, an inhibitor of phosphatidylinositol-3 kinase (PI3K), in the concentration of more than 50 microM potentiates lipolysis induced by adenosine deaminase in adipocytes from fed rats (f-adipocytes), but not from starved rats (s-adipocytes).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	adenosine deaminase	Rattus norvegicus	170-189
15144225-6	2004	This benzo[a]pyrene-induced osteoblast proliferation could be inhibited by the estrogen receptor antagonist ICI182780 and tamoxifen, PD98059 [extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) inhibitor], and LY294002 [phosphatidylinositol 3-kinase (PI3K) inhibitor] but not alpha-naphthoflavone (aryl hydrocarbon receptor antagonist) and SB203580 (p38 MAPK inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	mitogen-activated protein kinase 1	Homo sapiens	142-179
14751548-4	2004	We blocked Mek, Mos and PI-3 kinase activities by a variety of means that included expression of dominant-negative kinase suppressor of Ras (DnKSR), expression of a dominant-negative PI-3 kinase (DnPI3K), treatment of oocytes with a Mek inhibitor (U1026) or PI-3 kinase (LY294002) inhibitor, and introduction of Mos antisense morpholinos.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	271-279	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	24-35
15111505-5	2004	Inhibition of the phosphatidylinositol 3"-kinase (PI 3"-kinase) pathway with LY294002 blocked insulin-stimulated O(2)(-) production, suggesting a direct involvement of PI 3"-kinase in the activation of NAD(P)H oxidase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	insulin	Homo sapiens	94-101
15140184-10	2004	Most interestingly, only the inhibitor of the PI3K/Akt pathway, LY294002, was able to block the survival effects of both IGF-1 and BDNF; an inhibitor of the MAPK pathway inhibitor, PD98059, being ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Homo sapiens	51-54
15067356-11	2004	Inhibition of PI 3-K with Wortmannin and LY294002 blocked Akt phosphorylation and inhibited expression of COX-2 in mutated-PTEN cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	58-61
15067356-11	2004	Inhibition of PI 3-K with Wortmannin and LY294002 blocked Akt phosphorylation and inhibited expression of COX-2 in mutated-PTEN cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
15067356-11	2004	Inhibition of PI 3-K with Wortmannin and LY294002 blocked Akt phosphorylation and inhibited expression of COX-2 in mutated-PTEN cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	phosphatase and tensin homolog	Homo sapiens	123-127
15140181-5	2004	We further demonstrate that LY294002-sensitive kinases are responsible for controlling serine 18 phosphorylation of p53, thereby regulating the pro-apoptotic activity of p53 in astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	transformation related protein 53, pseudogene	Mus musculus	116-119
15140181-5	2004	We further demonstrate that LY294002-sensitive kinases are responsible for controlling serine 18 phosphorylation of p53, thereby regulating the pro-apoptotic activity of p53 in astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	transformation related protein 53, pseudogene	Mus musculus	170-173
15140184-10	2004	Most interestingly, only the inhibitor of the PI3K/Akt pathway, LY294002, was able to block the survival effects of both IGF-1 and BDNF; an inhibitor of the MAPK pathway inhibitor, PD98059, being ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	insulin like growth factor 1	Homo sapiens	121-126
15140184-10	2004	Most interestingly, only the inhibitor of the PI3K/Akt pathway, LY294002, was able to block the survival effects of both IGF-1 and BDNF; an inhibitor of the MAPK pathway inhibitor, PD98059, being ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	brain derived neurotrophic factor	Homo sapiens	131-135
15093685-6	2004	Continuous inhibition of phosphoinositide 3-kinase (PI3K) with 10 microM LY294002 suppressed post-hypoxic phospho-Akt levels, prevented post-hypoxic cytosolic cyt c reductions, and increased apoptosis evaluated by TUNEL staining and DNA fragmentation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	25-50
15194403-8	2004	Meanwhile, the protective effect of insulin was partially blocked with an inhibitor of PI3-kinase, LY294002, suggesting the utilization of PI3-kinase/Akt signaling pathway for the observed cytoprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	thymoma viral proto-oncogene 1	Mus musculus	150-153
14985354-5	2004	Furthermore, androgen receptor phosphorylation was augmented by LY294002, an indirect inhibitor of protein kinase B/Akt that inhibits glycogen synthase kinase-3 beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	androgen receptor	Homo sapiens	13-30
14985354-5	2004	Furthermore, androgen receptor phosphorylation was augmented by LY294002, an indirect inhibitor of protein kinase B/Akt that inhibits glycogen synthase kinase-3 beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Homo sapiens	116-119
14985354-5	2004	Furthermore, androgen receptor phosphorylation was augmented by LY294002, an indirect inhibitor of protein kinase B/Akt that inhibits glycogen synthase kinase-3 beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	glycogen synthase kinase 3 beta	Homo sapiens	134-165
14985355-7	2004	Wortmannin and LY294002, inhibitors of phosphoinositide 3-kinase, and PD98059, an inhibitor of MEK, abrogated survival and capillary tube formation, indicating that Akt and Erk1/2 should promote survival and capillary tube formation of these endothelial cells at a locus downstream to stem cell factor/c-kit signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	165-168
15093685-6	2004	Continuous inhibition of phosphoinositide 3-kinase (PI3K) with 10 microM LY294002 suppressed post-hypoxic phospho-Akt levels, prevented post-hypoxic cytosolic cyt c reductions, and increased apoptosis evaluated by TUNEL staining and DNA fragmentation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
15071185-7	2004	In contrast, Ad-induced TNF-alpha production and DC maturation were dependent on signaling by phosphoinositide-3-OH kinase (PI3K), as determined by wortmannin and LY294002 blocking experiments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	tumor necrosis factor	Mus musculus	24-33
15047168-7	2004	Phosphorylation of Akt at serine 473 and its downstream molecular Bad at serine 136 was induced by HAPO, but was blocked by two PI3K inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	AKT serine/threonine kinase 1	Homo sapiens	19-22
15047168-9	2004	Such an effect of HAPO was also significantly blocked by either LY294002 or wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	proteoglycan 4	Homo sapiens	18-22
15044083-3	2004	TGFbeta-mediated phosphorylation of Akt at Ser-473 was inhibited by dominant-negative ILK and PI3K inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Homo sapiens	36-39
15044083-3	2004	TGFbeta-mediated phosphorylation of Akt at Ser-473 was inhibited by dominant-negative ILK and PI3K inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	transforming growth factor beta 1	Homo sapiens	0-7
14988229-8	2004	The phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin or LY294002 abolished the activation of Akt/eNOS and reversed the inhibitory effect of rHDL on TF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-33
14988229-8	2004	The phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin or LY294002 abolished the activation of Akt/eNOS and reversed the inhibitory effect of rHDL on TF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	103-106
14988229-8	2004	The phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin or LY294002 abolished the activation of Akt/eNOS and reversed the inhibitory effect of rHDL on TF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	coagulation factor III, tissue factor	Homo sapiens	158-160
15044083-3	2004	TGFbeta-mediated phosphorylation of Akt at Ser-473 was inhibited by dominant-negative ILK and PI3K inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	integrin linked kinase	Homo sapiens	86-89
15044083-5	2004	This increased ILK activity by TGFbeta was lowered by PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	integrin linked kinase	Homo sapiens	15-18
15044083-5	2004	This increased ILK activity by TGFbeta was lowered by PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	transforming growth factor beta 1	Homo sapiens	31-38
14747473-5	2004	The pathway through which EGFR activates PKCdelta is suggested by the fact that the MEK-1 inhibitor U0126 and the phosphatidylinositol 3-kinase inhibitor LY294002 had no effect on PKCdelta activation, whereas lack of PLCgamma signaling resulted in delayed PKCdelta activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	epidermal growth factor receptor	Homo sapiens	26-30
15087391-6	2004	Moreover, inhibition of the MEK-MAPK pathway by the specific inhibitor, UO126, rescued the cells from apoptosis, whereas the inhibition of phosphoinositide 3-kinase by its specific inhibitor, LY294002, promoted apoptosis in RENT4 cells expressing activated K-Ras.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	192-200	KRAS proto-oncogene, GTPase	Rattus norvegicus	257-262
14747473-5	2004	The pathway through which EGFR activates PKCdelta is suggested by the fact that the MEK-1 inhibitor U0126 and the phosphatidylinositol 3-kinase inhibitor LY294002 had no effect on PKCdelta activation, whereas lack of PLCgamma signaling resulted in delayed PKCdelta activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	protein kinase C delta	Homo sapiens	41-49
15059890-4	2004	Here, we show that H2AX phosphorylation after exposure to ionizing radiation (IR) occurs to similar extents in human fibroblasts and in mouse embryo fibroblasts lacking either DNA-PK or ATM but is ablated in ATM-deficient cells treated with LY294002, a drug that specifically inhibits DNA-PK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	241-249	H2A.X variant histone	Homo sapiens	19-23
15020231-6	2004	Catalase-induced COX-2 expression was abrogated by treatment of MG-132 (a NF-kappaB inhibitor) or LY294002 (a PI3K inhibitor), but not by treatment of PD98059 (an ERK inhibitor), SB203580 (a p38 inhibitor), or SP600125 (a JNK inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	catalase	Homo sapiens	0-8
15020231-6	2004	Catalase-induced COX-2 expression was abrogated by treatment of MG-132 (a NF-kappaB inhibitor) or LY294002 (a PI3K inhibitor), but not by treatment of PD98059 (an ERK inhibitor), SB203580 (a p38 inhibitor), or SP600125 (a JNK inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22
15020231-7	2004	Moreover, inhibition of PI3K by LY294002 caused partial decrease of catalase-induced COX-2 transcription and steady-state COX-2 transcript levels, but not COX-2 mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	catalase	Homo sapiens	68-76
15020231-7	2004	Moreover, inhibition of PI3K by LY294002 caused partial decrease of catalase-induced COX-2 transcription and steady-state COX-2 transcript levels, but not COX-2 mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-90
15020231-7	2004	Moreover, inhibition of PI3K by LY294002 caused partial decrease of catalase-induced COX-2 transcription and steady-state COX-2 transcript levels, but not COX-2 mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
15020231-7	2004	Moreover, inhibition of PI3K by LY294002 caused partial decrease of catalase-induced COX-2 transcription and steady-state COX-2 transcript levels, but not COX-2 mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
15013849-6	2004	Suppression of Akt activity by wortmannin, by LY-294002 and by using a dominant negative Akt mutant abolished the anti-apoptotic effect of Andro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-55	AKT serine/threonine kinase 1	Homo sapiens	15-18
15059911-3	2004	Both Ly294002 and U0126, a mitogen-activated protein kinase kinase 1/2 inhibitor, reduced invasion, which correlated with reduction of the metalloproteinase matrix metalloproteinase 2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	mitogen-activated protein kinase kinase 1	Mus musculus	27-70
15073105-6	2004	The activation of Akt and NF-kappa B was prevented by LY294002, whereas the activity of MAPK(Erk), but not NF-kappa B, was inhibited by U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	18-21
15073105-6	2004	The activation of Akt and NF-kappa B was prevented by LY294002, whereas the activity of MAPK(Erk), but not NF-kappa B, was inhibited by U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	nuclear factor kappa B subunit 1	Homo sapiens	26-36
15072575-6	2004	Conversely, chemicals known to inhibit the mammalian insulin receptor or downstream elements of its signaling pathway, such as LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), were able to prevent the steroidogenic action of bovine insulin on fly ovaries.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	insulin receptor	Homo sapiens	53-69
14978738-5	2004	Treatment of cells with PI-3K/Akt inhibitor (LY294002) and tyrosine protein kinase inhibitor (genistein) significantly attenuated hypoxia-induced PAI-1 mRNA and protein expression as well as promoter activation, apparently via an inhibition of the hypoxia-induced stabilization of HIF-1alpha protein, attenuation of the steady-state level of HIF-1alpha mRNA, and its DNA-binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	30-33
14978738-5	2004	Treatment of cells with PI-3K/Akt inhibitor (LY294002) and tyrosine protein kinase inhibitor (genistein) significantly attenuated hypoxia-induced PAI-1 mRNA and protein expression as well as promoter activation, apparently via an inhibition of the hypoxia-induced stabilization of HIF-1alpha protein, attenuation of the steady-state level of HIF-1alpha mRNA, and its DNA-binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	serpin family E member 1	Homo sapiens	146-151
14978738-5	2004	Treatment of cells with PI-3K/Akt inhibitor (LY294002) and tyrosine protein kinase inhibitor (genistein) significantly attenuated hypoxia-induced PAI-1 mRNA and protein expression as well as promoter activation, apparently via an inhibition of the hypoxia-induced stabilization of HIF-1alpha protein, attenuation of the steady-state level of HIF-1alpha mRNA, and its DNA-binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	281-291
14978738-5	2004	Treatment of cells with PI-3K/Akt inhibitor (LY294002) and tyrosine protein kinase inhibitor (genistein) significantly attenuated hypoxia-induced PAI-1 mRNA and protein expression as well as promoter activation, apparently via an inhibition of the hypoxia-induced stabilization of HIF-1alpha protein, attenuation of the steady-state level of HIF-1alpha mRNA, and its DNA-binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	342-352
15115616-4	2004	In this study, we found that H-Ras interacted with ASK1 to cause the inhibition of both ASK1 activity and ASK1-induced apoptosis in vivo, which was reversed only partially by addition of RafS621A, an antagonist of Raf, whereas MEK inhibitor, PD98059, and PI3K inhibitor, LY294002, did not disturb the inhibitory effect of H-Ras on ASK-1-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	271-279	HRas proto-oncogene, GTPase	Homo sapiens	29-34
15115616-4	2004	In this study, we found that H-Ras interacted with ASK1 to cause the inhibition of both ASK1 activity and ASK1-induced apoptosis in vivo, which was reversed only partially by addition of RafS621A, an antagonist of Raf, whereas MEK inhibitor, PD98059, and PI3K inhibitor, LY294002, did not disturb the inhibitory effect of H-Ras on ASK-1-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	271-279	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	51-55
15115616-4	2004	In this study, we found that H-Ras interacted with ASK1 to cause the inhibition of both ASK1 activity and ASK1-induced apoptosis in vivo, which was reversed only partially by addition of RafS621A, an antagonist of Raf, whereas MEK inhibitor, PD98059, and PI3K inhibitor, LY294002, did not disturb the inhibitory effect of H-Ras on ASK-1-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	271-279	zinc fingers and homeoboxes 2	Homo sapiens	187-190
14715711-4	2004	Leptin caused a time- and dose-dependent significant increase in proliferation of HL-1 cells that was inhibited by preincubation with PD98059 and LY294002, suggesting that leptin mediated proliferation via extracellular signal-regulated kinase-1/2- and phosphatidylinositol-3-kinase-dependent signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	leptin	Homo sapiens	0-6
14715711-4	2004	Leptin caused a time- and dose-dependent significant increase in proliferation of HL-1 cells that was inhibited by preincubation with PD98059 and LY294002, suggesting that leptin mediated proliferation via extracellular signal-regulated kinase-1/2- and phosphatidylinositol-3-kinase-dependent signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	leptin	Homo sapiens	172-178
14715711-4	2004	Leptin caused a time- and dose-dependent significant increase in proliferation of HL-1 cells that was inhibited by preincubation with PD98059 and LY294002, suggesting that leptin mediated proliferation via extracellular signal-regulated kinase-1/2- and phosphatidylinositol-3-kinase-dependent signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	mitogen-activated protein kinase 3	Homo sapiens	206-245
15066181-3	2004	Treatment of human melanoma cells A2058 with LPA increased phosphorylation and activation of PAK1, which was blocked by treatment with pertussis toxin and by inhibition of phosphoinositide 3-kinase (PI3K) with an inhibitor LY294002 or by overexpression of catalytically inactive mutant of PI3Kgamma, indicating that LPA-induced PAK1 activation was mediated via a Gi protein and the PI3Kgamma signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	223-231	p21 (RAC1) activated kinase 1	Homo sapiens	93-97
15023522-7	2004	STAT-3 and ERK1/2 phosphorylation as well as NF-kappaB activation were inhibited by pretreatment with the Jak-2 antagonist AG490, the ERK1/2 inhibitor PD98059, the free radical scavenger vitamin E, the NADPH-oxidase inhibitor DPI, as well as by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	signal transducer and activator of transcription 3	Mus musculus	0-6
15023522-7	2004	STAT-3 and ERK1/2 phosphorylation as well as NF-kappaB activation were inhibited by pretreatment with the Jak-2 antagonist AG490, the ERK1/2 inhibitor PD98059, the free radical scavenger vitamin E, the NADPH-oxidase inhibitor DPI, as well as by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	mitogen-activated protein kinase 3	Mus musculus	11-17
15023522-7	2004	STAT-3 and ERK1/2 phosphorylation as well as NF-kappaB activation were inhibited by pretreatment with the Jak-2 antagonist AG490, the ERK1/2 inhibitor PD98059, the free radical scavenger vitamin E, the NADPH-oxidase inhibitor DPI, as well as by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	Janus kinase 2	Mus musculus	106-111
15023522-7	2004	STAT-3 and ERK1/2 phosphorylation as well as NF-kappaB activation were inhibited by pretreatment with the Jak-2 antagonist AG490, the ERK1/2 inhibitor PD98059, the free radical scavenger vitamin E, the NADPH-oxidase inhibitor DPI, as well as by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	mitogen-activated protein kinase 3	Mus musculus	134-140
15072575-6	2004	Conversely, chemicals known to inhibit the mammalian insulin receptor or downstream elements of its signaling pathway, such as LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), were able to prevent the steroidogenic action of bovine insulin on fly ovaries.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	153-182
15072575-6	2004	Conversely, chemicals known to inhibit the mammalian insulin receptor or downstream elements of its signaling pathway, such as LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), were able to prevent the steroidogenic action of bovine insulin on fly ovaries.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	insulin	Bos taurus	53-60
15024078-5	2004	Growth factor-mediated induction of HIF-1alpha was ablated by transient expression of a dominant negative form of Akt/PKB or by treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	hypoxia inducible factor 1, alpha subunit	Mus musculus	36-46
15065019-11	2004	Combination treatment with LY294002 and TRAIL increased apoptosis of SK-N-SH cells compared with TRAIL alone; these results were further corroborated by complete inhibition of apoptosis by caspase-3 or pan-caspase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	TNF superfamily member 10	Homo sapiens	97-102
15065019-11	2004	Combination treatment with LY294002 and TRAIL increased apoptosis of SK-N-SH cells compared with TRAIL alone; these results were further corroborated by complete inhibition of apoptosis by caspase-3 or pan-caspase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	caspase 3	Homo sapiens	189-198
15084985-2	2004	We postulated that LY294002, a PI3K inhibitor, might inactivate Akt, consequently inhibiting cell proliferation in 3 human pancreatic ductal carcinoma cell lines, PSN-1, PANC-1, and KP-4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	64-67
15084985-2	2004	We postulated that LY294002, a PI3K inhibitor, might inactivate Akt, consequently inhibiting cell proliferation in 3 human pancreatic ductal carcinoma cell lines, PSN-1, PANC-1, and KP-4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	5'-nucleotidase, cytosolic IIIA	Homo sapiens	163-168
15084985-3	2004	LY294002 (50 micromol/L) caused a decrease in phosphorylated Akt and inhibition of cell proliferation in a time-dependent manner, but there was no obvious induction of apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	61-64
15084985-4	2004	Flow cytometric analysis revealed that pancreatic cancer cells treated with 50 micromol/L LY294002 underwent G1 arrest, which was associated with dephosphorylation of the ppRB protein, a decrease in the protein expression of cyclin D and E, and their activating partners Cdk2, 4, and 6 with simultaneous accumulation of P27/Kip1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	cyclin dependent kinase 2	Homo sapiens	271-275
15084985-4	2004	Flow cytometric analysis revealed that pancreatic cancer cells treated with 50 micromol/L LY294002 underwent G1 arrest, which was associated with dephosphorylation of the ppRB protein, a decrease in the protein expression of cyclin D and E, and their activating partners Cdk2, 4, and 6 with simultaneous accumulation of P27/Kip1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	interferon alpha inducible protein 27	Homo sapiens	320-323
15084985-4	2004	Flow cytometric analysis revealed that pancreatic cancer cells treated with 50 micromol/L LY294002 underwent G1 arrest, which was associated with dephosphorylation of the ppRB protein, a decrease in the protein expression of cyclin D and E, and their activating partners Cdk2, 4, and 6 with simultaneous accumulation of P27/Kip1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	cyclin dependent kinase inhibitor 1B	Homo sapiens	324-328
15050414-11	2004	4-OHE2, but not 2-OHE2, also induced Akt phosphorylation at Ser473 in dose- and time-dependent manners, and LY294002 and wortmannin inhibited Akt phosphorylation at Ser473 induced by 4-OHE2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Homo sapiens	142-145
15016316-13	2004	Inhibition of PI 3-K with Wortmannin and LY294002 blocked IkappaB phosphorylation, reduced NF-kappaB nuclear activity, reduced COX-2 expression and induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	nuclear factor kappa B subunit 1	Homo sapiens	91-100
14711831-2	2004	Insulin internalization was decreased by 50% upon incubation of the cells with the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	insulin	Homo sapiens	0-7
14711831-2	2004	Insulin internalization was decreased by 50% upon incubation of the cells with the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	83-112
15040022-8	2004	5 mumol/L LY294002 inhibited the expression of VEGF stimulated by cobalt chloride or recombinant human EGF and the inhibition decreased step by step with increase of the concentration of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	vascular endothelial growth factor A	Homo sapiens	47-51
15040022-8	2004	5 mumol/L LY294002 inhibited the expression of VEGF stimulated by cobalt chloride or recombinant human EGF and the inhibition decreased step by step with increase of the concentration of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	epidermal growth factor	Homo sapiens	48-51
15040022-8	2004	5 mumol/L LY294002 inhibited the expression of VEGF stimulated by cobalt chloride or recombinant human EGF and the inhibition decreased step by step with increase of the concentration of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	vascular endothelial growth factor A	Homo sapiens	47-51
15040022-8	2004	5 mumol/L LY294002 inhibited the expression of VEGF stimulated by cobalt chloride or recombinant human EGF and the inhibition decreased step by step with increase of the concentration of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	epidermal growth factor	Homo sapiens	48-51
15050414-10	2004	Our findings indicate that PI3K inhibitors, LY294002 and wortmannin, inhibited HIF-1alpha and VEGF-A expression, whereas MAPK inhibitor, PD98059, did not alter HIF-1alpha and VEGF-A expression induced by 4-OHE2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
15050414-10	2004	Our findings indicate that PI3K inhibitors, LY294002 and wortmannin, inhibited HIF-1alpha and VEGF-A expression, whereas MAPK inhibitor, PD98059, did not alter HIF-1alpha and VEGF-A expression induced by 4-OHE2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	vascular endothelial growth factor A	Homo sapiens	94-100
14660586-4	2004	The phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 and wortmannin abrogated AdE4(+) induction of both phospho-Akt expression and prolonged EC survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	120-123
15016316-13	2004	Inhibition of PI 3-K with Wortmannin and LY294002 blocked IkappaB phosphorylation, reduced NF-kappaB nuclear activity, reduced COX-2 expression and induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	prostaglandin-endoperoxide synthase 2	Homo sapiens	127-132
14707040-6	2004	Pertussis toxin, wortmannin, and LY294002 inhibited C-peptide-induced monocyte chemotaxis, suggesting the involvement of pertussis toxin-sensitive G-proteins as well as a phosphoinositide 3-kinase (PI3K)-dependent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	insulin	Homo sapiens	52-61
14660591-4	2004	Insulin treatment induced p70S6K, mTOR, and Akt phosphorylation, effects that were completely prevented by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	ribosomal protein S6 kinase B1	Rattus norvegicus	26-32
14660591-4	2004	Insulin treatment induced p70S6K, mTOR, and Akt phosphorylation, effects that were completely prevented by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	mechanistic target of rapamycin kinase	Rattus norvegicus	34-38
14660591-4	2004	Insulin treatment induced p70S6K, mTOR, and Akt phosphorylation, effects that were completely prevented by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Rattus norvegicus	44-47
14600031-7	2004	However, sustained activation of the PI 3-K pathway by HGF was inhibited by treatment with KC, and mimicking this effect by treatment with LY-294002 2 h after HGF stimulation reproduced the inhibition of HGF-stimulated branching morphogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-148	hepatocyte growth factor	Mus musculus	159-162
14600031-7	2004	However, sustained activation of the PI 3-K pathway by HGF was inhibited by treatment with KC, and mimicking this effect by treatment with LY-294002 2 h after HGF stimulation reproduced the inhibition of HGF-stimulated branching morphogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-148	hepatocyte growth factor	Mus musculus	159-162
14640974-6	2004	The PI3K inhibitor LY294002 inhibited the ActD-induced activation of Akt and p70S6K, and completely abolished the effects of PLD1 or PLD2, whereas inhibition of ERK activity by the MEK inhibitor U0126 had a milder effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	phospholipase D1	Cricetulus griseus	125-129
14707040-6	2004	Pertussis toxin, wortmannin, and LY294002 inhibited C-peptide-induced monocyte chemotaxis, suggesting the involvement of pertussis toxin-sensitive G-proteins as well as a phosphoinositide 3-kinase (PI3K)-dependent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	171-196
14991075-4	2004	Three lines of evidence indicate that the increase in CD36 is caused by defective insulin signaling: (a) Treatment of wild-type macrophages with LY294002, an inhibitor of insulin signaling via PI3K, results in an increase in CD36; (b) insulin receptor knockout macrophages show a post-transcriptional increase in CD36 protein; and (c) administration of thiazolidinediones to intact ob/ob mice and ob/ob, LDL receptor-deficient mice results in a reversal of macrophage insulin receptor defects and decreases CD36 protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	insulin receptor	Mus musculus	235-251
14640974-6	2004	The PI3K inhibitor LY294002 inhibited the ActD-induced activation of Akt and p70S6K, and completely abolished the effects of PLD1 or PLD2, whereas inhibition of ERK activity by the MEK inhibitor U0126 had a milder effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	LOW QUALITY PROTEIN: phospholipase D2	Cricetulus griseus	133-137
14627548-7	2004	Phosphorylation of eNOS Ser1177 under shear stress was elevated by 20 min, a response that was blocked by the phosphatidyl inositol-3-kinase (PI-3K)-inhibitors wortmannin and LY294002 but not by the mitogen activated protein kinase kinase (MEK)-inhibitor UO126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	110-140
14627548-7	2004	Phosphorylation of eNOS Ser1177 under shear stress was elevated by 20 min, a response that was blocked by the phosphatidyl inositol-3-kinase (PI-3K)-inhibitors wortmannin and LY294002 but not by the mitogen activated protein kinase kinase (MEK)-inhibitor UO126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	mitogen-activated protein kinase kinase 7	Homo sapiens	199-238
14627548-7	2004	Phosphorylation of eNOS Ser1177 under shear stress was elevated by 20 min, a response that was blocked by the phosphatidyl inositol-3-kinase (PI-3K)-inhibitors wortmannin and LY294002 but not by the mitogen activated protein kinase kinase (MEK)-inhibitor UO126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	mitogen-activated protein kinase kinase 7	Homo sapiens	240-243
15020266-8	2004	Yet, PI3K inhibitor LY294002 significantly reduced AM80-elicted ERK-1/-2 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	mitogen-activated protein kinase 3	Homo sapiens	64-72
14996943-9	2004	The increased binding of RIIbeta to AKAP3 induced by LY294002 is mainly due to tyrosine phosphorylation of AKAP3, since it is completely blocked by the tyrosine kinase inhibitor erbstatin, which also reverses the effects of LY294002 on motility and suppresses PKA-AKAP3 interaction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	A-kinase anchoring protein 3	Homo sapiens	36-41
14996943-9	2004	The increased binding of RIIbeta to AKAP3 induced by LY294002 is mainly due to tyrosine phosphorylation of AKAP3, since it is completely blocked by the tyrosine kinase inhibitor erbstatin, which also reverses the effects of LY294002 on motility and suppresses PKA-AKAP3 interaction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	A-kinase anchoring protein 3	Homo sapiens	107-112
14996943-9	2004	The increased binding of RIIbeta to AKAP3 induced by LY294002 is mainly due to tyrosine phosphorylation of AKAP3, since it is completely blocked by the tyrosine kinase inhibitor erbstatin, which also reverses the effects of LY294002 on motility and suppresses PKA-AKAP3 interaction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	A-kinase anchoring protein 3	Homo sapiens	107-112
14996943-9	2004	The increased binding of RIIbeta to AKAP3 induced by LY294002 is mainly due to tyrosine phosphorylation of AKAP3, since it is completely blocked by the tyrosine kinase inhibitor erbstatin, which also reverses the effects of LY294002 on motility and suppresses PKA-AKAP3 interaction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	A-kinase anchoring protein 3	Homo sapiens	36-41
14999683-10	2004	Pretreatment of PHH with the PI3K inhibitor LY294002 as well as adenoviral transduction of dominant negative Akt1 prevented HGF-mediated Mcl-1 induction and reversed the antiapoptotic effects of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	hepatocyte growth factor	Homo sapiens	124-127
14999683-10	2004	Pretreatment of PHH with the PI3K inhibitor LY294002 as well as adenoviral transduction of dominant negative Akt1 prevented HGF-mediated Mcl-1 induction and reversed the antiapoptotic effects of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	137-142
14999683-10	2004	Pretreatment of PHH with the PI3K inhibitor LY294002 as well as adenoviral transduction of dominant negative Akt1 prevented HGF-mediated Mcl-1 induction and reversed the antiapoptotic effects of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	hepatocyte growth factor	Homo sapiens	195-198
14691717-5	2004	LY294002, a specific inhibitor of phosphatidylinositol 3-kinase(PI3K)/Akt signaling, also suppressed TGF-beta-induced motility and Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	70-73
14691717-5	2004	LY294002, a specific inhibitor of phosphatidylinositol 3-kinase(PI3K)/Akt signaling, also suppressed TGF-beta-induced motility and Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	131-134
14996943-9	2004	The increased binding of RIIbeta to AKAP3 induced by LY294002 is mainly due to tyrosine phosphorylation of AKAP3, since it is completely blocked by the tyrosine kinase inhibitor erbstatin, which also reverses the effects of LY294002 on motility and suppresses PKA-AKAP3 interaction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	A-kinase anchoring protein 3	Homo sapiens	107-112
14996943-9	2004	The increased binding of RIIbeta to AKAP3 induced by LY294002 is mainly due to tyrosine phosphorylation of AKAP3, since it is completely blocked by the tyrosine kinase inhibitor erbstatin, which also reverses the effects of LY294002 on motility and suppresses PKA-AKAP3 interaction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	A-kinase anchoring protein 3	Homo sapiens	107-112
14991075-4	2004	Three lines of evidence indicate that the increase in CD36 is caused by defective insulin signaling: (a) Treatment of wild-type macrophages with LY294002, an inhibitor of insulin signaling via PI3K, results in an increase in CD36; (b) insulin receptor knockout macrophages show a post-transcriptional increase in CD36 protein; and (c) administration of thiazolidinediones to intact ob/ob mice and ob/ob, LDL receptor-deficient mice results in a reversal of macrophage insulin receptor defects and decreases CD36 protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	insulin receptor	Mus musculus	468-484
14996943-10	2004	The requirement of PKA binding to AKAP3 for sperm motility is confirmed by the reduction of motility induced by an inhibitor of RIIbeta-AKAP3 binding, Ht31, whose effects on sperm motility and PKA binding to AKAP3 are reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	230-238	A-kinase anchoring protein 3	Homo sapiens	34-39
14996943-10	2004	The requirement of PKA binding to AKAP3 for sperm motility is confirmed by the reduction of motility induced by an inhibitor of RIIbeta-AKAP3 binding, Ht31, whose effects on sperm motility and PKA binding to AKAP3 are reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	230-238	A-kinase anchoring protein 3	Homo sapiens	136-141
14978074-2	2004	We show that cyclin D2 induction is blocked by the PI-3K inhibitors wortmannin and LY294002, which coincides with impaired BCR-mediated mitogen-activated protein/extracellular signal-related kinase kinase (MEK)1/2 and p42/44ERK phosphorylation on activation residues.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	cyclin D2	Mus musculus	13-22
14996943-10	2004	The requirement of PKA binding to AKAP3 for sperm motility is confirmed by the reduction of motility induced by an inhibitor of RIIbeta-AKAP3 binding, Ht31, whose effects on sperm motility and PKA binding to AKAP3 are reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	230-238	A-kinase anchoring protein 3	Homo sapiens	136-141
14978074-2	2004	We show that cyclin D2 induction is blocked by the PI-3K inhibitors wortmannin and LY294002, which coincides with impaired BCR-mediated mitogen-activated protein/extracellular signal-related kinase kinase (MEK)1/2 and p42/44ERK phosphorylation on activation residues.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	mitogen-activated protein kinase kinase 1	Mus musculus	162-213
14978074-2	2004	We show that cyclin D2 induction is blocked by the PI-3K inhibitors wortmannin and LY294002, which coincides with impaired BCR-mediated mitogen-activated protein/extracellular signal-related kinase kinase (MEK)1/2 and p42/44ERK phosphorylation on activation residues.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	cyclin-dependent kinase 20	Mus musculus	218-221
15026550-8	2004	Inhibition of Akt activation by LY294002 significantly decreased the viability of human cholangiocarcinoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	14-17
14988008-3	2004	Pretreatment with the specific inhibitor of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway, LY294002 (20 microM), prevented the phosphorylation of Akt but did not affect the phosphorylation of GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	AKT serine/threonine kinase 1	Homo sapiens	85-88
15033167-6	2004	Inhibiting the increase in Akt phosphorylation by intravitreal injection of wortmannin and LY294002, inhibitors of PI3K, resulted in premature nuclear fragmentation, caspases-3 and -9 activation in the ganglion cell layer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	AKT serine/threonine kinase 1	Homo sapiens	27-30
15033167-6	2004	Inhibiting the increase in Akt phosphorylation by intravitreal injection of wortmannin and LY294002, inhibitors of PI3K, resulted in premature nuclear fragmentation, caspases-3 and -9 activation in the ganglion cell layer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	caspase 3	Homo sapiens	166-183
15033174-3	2004	This effect was specifically blocked by inhibitors of phosphatidylinositol 3-kinase (PI3-K) pathways (LY294002 and wortmannin) or p42/p44 mitogen-activated protein (MAP) kinase (PD98059 and U0126).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	54-83
14988008-3	2004	Pretreatment with the specific inhibitor of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway, LY294002 (20 microM), prevented the phosphorylation of Akt but did not affect the phosphorylation of GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	AKT serine/threonine kinase 1	Homo sapiens	153-156
14987993-3	2004	BK stimulated PGE(2) release in cultured HPASMC was inhibited by the PI 3-kinase inhibitor LY294002 and the p38 MAP kinase inhibitor SB202190.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	kininogen 1	Homo sapiens	0-2
14988008-3	2004	Pretreatment with the specific inhibitor of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway, LY294002 (20 microM), prevented the phosphorylation of Akt but did not affect the phosphorylation of GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	glycogen synthase kinase 3 beta	Homo sapiens	199-208
14987993-4	2004	The inhibitory mechanism used by LY294002 did not involve cytosolic PLA(2) activation or COX-1, COX-2 and PGES protein expression but rather a novel effect on COX enzymatic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	phospholipase A2 group IB	Homo sapiens	68-74
14987993-4	2004	The inhibitory mechanism used by LY294002 did not involve cytosolic PLA(2) activation or COX-1, COX-2 and PGES protein expression but rather a novel effect on COX enzymatic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
14762163-5	2004	Platelet-derived growth factor (PDGF)-induced oxidation of endogenous SHP-2, sensitive to treatment with the phosphatidylinositol 3-kinase inhibitor LY294002, was demonstrated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	70-75
14987993-4	2004	The inhibitory mechanism used by LY294002 did not involve cytosolic PLA(2) activation or COX-1, COX-2 and PGES protein expression but rather a novel effect on COX enzymatic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	prostaglandin E synthase	Homo sapiens	106-110
14741719-6	2004	AG-490, wortmannin, and LY294002 blocked the induction by IL-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	interleukin 2	Mus musculus	58-62
14645251-2	2004	The phosphatidylinositol 3-OH-kinase inhibitor LY294002 has been shown to block cyclin D1 accumulation, CDK4 activity and, thus, G1 progression in alpha-thrombin-stimulated IIC9 cells (Chinese hamster embryonic fibroblasts).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	G1/S-specific cyclin-D1	Cricetulus griseus	80-89
14645251-2	2004	The phosphatidylinositol 3-OH-kinase inhibitor LY294002 has been shown to block cyclin D1 accumulation, CDK4 activity and, thus, G1 progression in alpha-thrombin-stimulated IIC9 cells (Chinese hamster embryonic fibroblasts).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	cyclin-dependent kinase 4	Cricetulus griseus	104-108
14563664-1	2004	The phosphoinositide 3-kinase (PI3K) inhibitor LY-294002 decreased steady-state contraction in neonatal rat ventricular myocytes (NRVM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-56	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	4-29
14645251-3	2004	Our previous results show that expression of cyclin E rescues S phase progression in alpha-thrombin-stimulated IIC9 cells treated with LY294002, arguing that cyclin E renders CDK4 activity dispensable for G1 progression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	cyclin-dependent kinase 4	Cricetulus griseus	175-179
14960322-0	2004	LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-C motif chemokine ligand 2	Homo sapiens	18-52
14960322-1	2004	The effects of LY294002 (LY29) and wortmannin (WM), inhibitors of phosphatidylinositol 3-kinase (PI3K), on monocyte chemoattractant protein-1 (MCP-1) expression by human umbilical vein endothelial cells were investigated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	C-C motif chemokine ligand 2	Homo sapiens	107-141
14960322-2	2004	Complete inhibition of interleukin (IL)-1beta-induced Akt phosphorylation occurred at 50 microM LY29 or 100 nM WM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-100	interleukin 1 beta	Homo sapiens	23-45
14960322-5	2004	LY29 and LY30 inhibited activation of nuclear factor-kappaB (NF-kappaB).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-4	nuclear factor kappa B subunit 1	Homo sapiens	38-59
14960322-5	2004	LY29 and LY30 inhibited activation of nuclear factor-kappaB (NF-kappaB).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-4	nuclear factor kappa B subunit 1	Homo sapiens	61-70
14960322-6	2004	These results suggest that LY29 inhibits MCP-1 expression at least in part via suppression of NF-kappaB, independent of PI3K, and the structure of LY29 and LY30 may be a novel template for development of new anti-inflammatory drugs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-31	C-C motif chemokine ligand 2	Homo sapiens	41-46
14960322-6	2004	These results suggest that LY29 inhibits MCP-1 expression at least in part via suppression of NF-kappaB, independent of PI3K, and the structure of LY29 and LY30 may be a novel template for development of new anti-inflammatory drugs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-31	nuclear factor kappa B subunit 1	Homo sapiens	94-103
14743465-6	2004	RESULTS: IGF-1, EGF, and heregulin but not PDGF or activators of protein kinase A induced phosphorylation of Akt in DU145 cells and activation was completely blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	insulin like growth factor 1	Homo sapiens	9-14
14743465-6	2004	RESULTS: IGF-1, EGF, and heregulin but not PDGF or activators of protein kinase A induced phosphorylation of Akt in DU145 cells and activation was completely blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	AKT serine/threonine kinase 1	Homo sapiens	109-112
14743465-7	2004	In the hormone-responsive prostate cancer cell line LNCaP that has a constitutively switched-on Akt kinase, LY294002 caused a dose- and time-dependent Akt inhibition, which was absent in long-term androgen-ablated LNCaP sublines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Homo sapiens	96-99
14743465-7	2004	In the hormone-responsive prostate cancer cell line LNCaP that has a constitutively switched-on Akt kinase, LY294002 caused a dose- and time-dependent Akt inhibition, which was absent in long-term androgen-ablated LNCaP sublines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Homo sapiens	151-154
14757120-6	2004	The MEK (MAPK kinase) inhibitor, U0126, which has been shown to induce growth arrest, inactivated ERK and down-regulated cyclins D and E. Although DIF-1 activated the phosphatidylinositol 3-kinase (PI-3K)/Akt pathway, neither wortmannin nor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002; PI-3K inhibitors) cancelled DIF-1-induced growth arrest.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	241-289	mitogen-activated protein kinase kinase 7	Homo sapiens	4-7
14757120-6	2004	The MEK (MAPK kinase) inhibitor, U0126, which has been shown to induce growth arrest, inactivated ERK and down-regulated cyclins D and E. Although DIF-1 activated the phosphatidylinositol 3-kinase (PI-3K)/Akt pathway, neither wortmannin nor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002; PI-3K inhibitors) cancelled DIF-1-induced growth arrest.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	291-299	mitogen-activated protein kinase kinase 7	Homo sapiens	4-7
14551055-3	2004	Using intact medial strips of the swine carotid artery, we found that inhibition of PI3-kinase by LY-294002 resulted in a concentration-dependent decrease in the contractile response to both agonist stimulation and membrane depolarization-dependent contractions and a decrease in Ca(2+)-dependent myosin light chain (MLC) phosphorylation, the primary step in the initiation of smooth muscle contraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-107	myosin light chain 1	Sus scrofa	297-315
14551055-3	2004	Using intact medial strips of the swine carotid artery, we found that inhibition of PI3-kinase by LY-294002 resulted in a concentration-dependent decrease in the contractile response to both agonist stimulation and membrane depolarization-dependent contractions and a decrease in Ca(2+)-dependent myosin light chain (MLC) phosphorylation, the primary step in the initiation of smooth muscle contraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-107	myosin light chain 1	Sus scrofa	317-320
14756823-5	2004	In addition, the phosphatidylinositide 3-kinase (PI3K)-specific inhibitors wortmannin and LY294002 reduced BDNF-induced activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	17-47
15102479-6	2004	Epo-independent terminal differentiation as well as normal Epo-induced differentiation were repressed by inhibitors of JAK2 (AG490), PI3K (LY294002), and the Src family kinases (PP2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	erythropoietin	Homo sapiens	0-3
15102479-6	2004	Epo-independent terminal differentiation as well as normal Epo-induced differentiation were repressed by inhibitors of JAK2 (AG490), PI3K (LY294002), and the Src family kinases (PP2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	erythropoietin	Homo sapiens	59-62
14764057-7	2004	Finally, glucose-stimulated OPN expression was inhibited by LY294002, an inhibitor of phosphatidylinositol 3-kinase activity, in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	secreted phosphoprotein 1	Homo sapiens	28-31
14872485-10	2004	NF-kappaB inhibitors N-acetyl-L-cysteine and Bay 11-7085 and PI 3-kinase inhibitor LY294002 inhibited the enhancing effects of IL-18, but MAPK p38 inhibitor SB203580, ERK inhibitor PD98059, and JNK inhibitor SP600125 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	interleukin 18	Homo sapiens	127-132
14762792-11	2004	CCK-induced responses in p110 gamma(-/-) acini were all further inhibited by LY294002, indicating the involvement of other PI3K isoform(s), in addition to PI3K gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	cholecystokinin	Mus musculus	0-3
14756823-5	2004	In addition, the phosphatidylinositide 3-kinase (PI3K)-specific inhibitors wortmannin and LY294002 reduced BDNF-induced activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	brain derived neurotrophic factor	Homo sapiens	107-111
15344880-3	2004	In these R- cells, PI3K inhibition by LY294002 enhanced insulin stimulation of ERK phosphorylation whereas LY294002 inhibited insulin stimulation of Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	mitogen-activated protein kinase 1	Mus musculus	79-82
14593092-5	2004	This activation is inhibited by PD98059 and wortmannin/LY294002, indicating a crucial role for mitogen-activated protein kinase kinase (MEK) and phosphatidylinositol 3-kinase (PI3K), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	dual specificity mitogen-activated protein kinase kinase 1	Cricetulus griseus	95-134
14593092-5	2004	This activation is inhibited by PD98059 and wortmannin/LY294002, indicating a crucial role for mitogen-activated protein kinase kinase (MEK) and phosphatidylinositol 3-kinase (PI3K), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	dual specificity mitogen-activated protein kinase kinase 1	Cricetulus griseus	136-139
14762343-4	2004	The effect of LY294002-mediated phosphoinositide 3-kinase inhibition on protein kinase B (Akt) activation and nuclear factor-kappaB signaling was determined by Western blot analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	protein tyrosine kinase 2 beta	Homo sapiens	72-88
14762343-4	2004	The effect of LY294002-mediated phosphoinositide 3-kinase inhibition on protein kinase B (Akt) activation and nuclear factor-kappaB signaling was determined by Western blot analysis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	90-93
14762343-8	2004	LY294002 treatment caused a significant dose-dependent inhibition of protein kinase B (Akt) activation and suppression of nuclear factor-kappaB transcriptional activity that was accompanied by elevation of IkappaB, the intrinsic inhibitor of nuclear factor-kappaB, and concomitant reduction of nuclear factor-kappaB-regulated antiapoptotic proteins cIAP1, cIAP2, and BclXL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein tyrosine kinase 2 beta	Homo sapiens	69-85
14762343-8	2004	LY294002 treatment caused a significant dose-dependent inhibition of protein kinase B (Akt) activation and suppression of nuclear factor-kappaB transcriptional activity that was accompanied by elevation of IkappaB, the intrinsic inhibitor of nuclear factor-kappaB, and concomitant reduction of nuclear factor-kappaB-regulated antiapoptotic proteins cIAP1, cIAP2, and BclXL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	87-90
14762343-8	2004	LY294002 treatment caused a significant dose-dependent inhibition of protein kinase B (Akt) activation and suppression of nuclear factor-kappaB transcriptional activity that was accompanied by elevation of IkappaB, the intrinsic inhibitor of nuclear factor-kappaB, and concomitant reduction of nuclear factor-kappaB-regulated antiapoptotic proteins cIAP1, cIAP2, and BclXL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	baculoviral IAP repeat containing 2	Homo sapiens	349-354
14762343-8	2004	LY294002 treatment caused a significant dose-dependent inhibition of protein kinase B (Akt) activation and suppression of nuclear factor-kappaB transcriptional activity that was accompanied by elevation of IkappaB, the intrinsic inhibitor of nuclear factor-kappaB, and concomitant reduction of nuclear factor-kappaB-regulated antiapoptotic proteins cIAP1, cIAP2, and BclXL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	baculoviral IAP repeat containing 3	Homo sapiens	356-361
14762343-8	2004	LY294002 treatment caused a significant dose-dependent inhibition of protein kinase B (Akt) activation and suppression of nuclear factor-kappaB transcriptional activity that was accompanied by elevation of IkappaB, the intrinsic inhibitor of nuclear factor-kappaB, and concomitant reduction of nuclear factor-kappaB-regulated antiapoptotic proteins cIAP1, cIAP2, and BclXL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2 like 1	Homo sapiens	367-372
14747535-7	2004	In the presence of LY294002, an inhibitor of PI3-K, the LMP2A-mediated inhibitory effects on TGF-beta 1-induced DNA fragmentation and cleavage of PARP were alleviated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	transforming growth factor beta 1	Homo sapiens	93-103
14747535-7	2004	In the presence of LY294002, an inhibitor of PI3-K, the LMP2A-mediated inhibitory effects on TGF-beta 1-induced DNA fragmentation and cleavage of PARP were alleviated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	poly(ADP-ribose) polymerase 1	Homo sapiens	146-150
14762343-10	2004	CONCLUSION: LY294002-mediated inhibition of the phosphoinositide 3-kinase/protein kinase B-dependent survival pathway with secondary suppression of nuclear factor-kappaB transcriptional activity was associated with enhancement of paclitaxel cytotoxicity in lung and esophageal cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	protein tyrosine kinase 2 beta	Homo sapiens	74-90
15344880-3	2004	In these R- cells, PI3K inhibition by LY294002 enhanced insulin stimulation of ERK phosphorylation whereas LY294002 inhibited insulin stimulation of Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	thymoma viral proto-oncogene 1	Mus musculus	149-152
14628071-5	2004	In this study, we tested the hypothesis that the inhibition of PI3K by LY294002 results in the dephosphorylation of AKT and BAD, and thus promote leukemia cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Homo sapiens	116-119
14595115-7	2004	An adenovirus encoding active Akt could partially restore terminal differentiation of MyoD-expressing and LY294002-treated myoblasts, but the resultant myofibers contained fewer nuclei and were smaller and thinner than normal, indicating that another PI3-kinase-stimulated pathway in addition to Akt is required for full myocyte maturation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	thymoma viral proto-oncogene 1	Mus musculus	30-33
14628071-7	2004	In MO7E cells, LY294002 reduced AKT kinase activity, induced dephosphorylation of AKT and BAD, and increased apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	32-35
14729969-5	2004	Conversely, expression of the 3-phosphoinositide phosphatase myotubularin or PI3-K inhibition by LY294002, wortmannin, or mutant p85 abolishes CKIP-1 binding to the membrane.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	X-linked myotubular myopathy gene 1	Mus musculus	61-73
14628071-7	2004	In MO7E cells, LY294002 reduced AKT kinase activity, induced dephosphorylation of AKT and BAD, and increased apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	82-85
14735194-11	2004	Inhibitors of extracellular regulated kinase (U0126) and p38 (SB203580), and to a lesser extent the phosphatidylinositol-3-kinase inhibitor LY294002, suppressed the action of TIMP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	TIMP metallopeptidase inhibitor 1	Homo sapiens	175-181
14729969-5	2004	Conversely, expression of the 3-phosphoinositide phosphatase myotubularin or PI3-K inhibition by LY294002, wortmannin, or mutant p85 abolishes CKIP-1 binding to the membrane.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	pleckstrin homology domain containing, family O member 1	Mus musculus	143-149
15068691-12	2004	Inhibition of the AKT pathway by LY 294002 strongly suppressed colony formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-42	AKT serine/threonine kinase 1	Homo sapiens	18-21
14610066-6	2004	The PI3K inhibitor LY294002 decreases TGF-beta1-stimulated alpha1(I) and alpha2(I) collagen mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	transforming growth factor beta 1	Homo sapiens	38-47
14610066-6	2004	The PI3K inhibitor LY294002 decreases TGF-beta1-stimulated alpha1(I) and alpha2(I) collagen mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	collagen type I alpha 2 chain	Homo sapiens	73-91
14679308-3	2004	In this report we demonstrate that VEGF-induced vessel morphogenesis of human umbilical vein endothelial cells (HUVEC) was inhibited by the transfection of a dominant negative, kinase-deficient ILK (ILK-KD), as well as by treatment with the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	281-289	vascular endothelial growth factor A	Homo sapiens	35-39
14610066-7	2004	Similarly, LY294002 or an Akt dominant negative construct blocks TGF-beta1 induction of COL1A2 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	transforming growth factor beta 1	Homo sapiens	65-74
14679308-3	2004	In this report we demonstrate that VEGF-induced vessel morphogenesis of human umbilical vein endothelial cells (HUVEC) was inhibited by the transfection of a dominant negative, kinase-deficient ILK (ILK-KD), as well as by treatment with the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	281-289	integrin linked kinase	Homo sapiens	194-197
14610066-7	2004	Similarly, LY294002 or an Akt dominant negative construct blocks TGF-beta1 induction of COL1A2 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	collagen type I alpha 2 chain	Homo sapiens	88-94
14679308-3	2004	In this report we demonstrate that VEGF-induced vessel morphogenesis of human umbilical vein endothelial cells (HUVEC) was inhibited by the transfection of a dominant negative, kinase-deficient ILK (ILK-KD), as well as by treatment with the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	281-289	integrin linked kinase	Homo sapiens	199-202
14610066-9	2004	LY294002 inhibits stimulation of COL1A2 promoter activity by Smad3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	collagen type I alpha 2 chain	Homo sapiens	33-39
14610066-9	2004	LY294002 inhibits stimulation of COL1A2 promoter activity by Smad3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	SMAD family member 3	Homo sapiens	61-66
14610066-12	2004	This induction is blocked by LY294002, suggesting that inhibition of the PI3K pathway decreases Smad3 transcriptional activity independently of C-terminal serine phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	SMAD family member 3	Homo sapiens	96-101
14610066-13	2004	However, TGF-beta1-induced total serine phosphorylation of Smad3 is decreased by LY294002, suggesting that Smad3 is phosphorylated by the PI3K pathway at serine residues other than the direct TGF-beta receptor I target site.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	transforming growth factor beta 1	Homo sapiens	9-18
14610066-13	2004	However, TGF-beta1-induced total serine phosphorylation of Smad3 is decreased by LY294002, suggesting that Smad3 is phosphorylated by the PI3K pathway at serine residues other than the direct TGF-beta receptor I target site.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	SMAD family member 3	Homo sapiens	59-64
14610066-13	2004	However, TGF-beta1-induced total serine phosphorylation of Smad3 is decreased by LY294002, suggesting that Smad3 is phosphorylated by the PI3K pathway at serine residues other than the direct TGF-beta receptor I target site.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	SMAD family member 3	Homo sapiens	107-112
14578214-6	2004	The phosphoinositide 3-OH kinase inhibitor Ly294002 prevented nuclear translocation of NF-kappaB and the subsequent release of interleukin-6 and macrophage inflammatory protein-2alpha in overventilated but not in endotoxic lungs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	nuclear factor kappa B subunit 1	Homo sapiens	87-96
14578214-6	2004	The phosphoinositide 3-OH kinase inhibitor Ly294002 prevented nuclear translocation of NF-kappaB and the subsequent release of interleukin-6 and macrophage inflammatory protein-2alpha in overventilated but not in endotoxic lungs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	interleukin 6	Homo sapiens	127-140
14578214-6	2004	The phosphoinositide 3-OH kinase inhibitor Ly294002 prevented nuclear translocation of NF-kappaB and the subsequent release of interleukin-6 and macrophage inflammatory protein-2alpha in overventilated but not in endotoxic lungs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	C-X-C motif chemokine ligand 2	Homo sapiens	145-183
14698040-9	2004	Furthermore, the inhibition of PI-3 kinase (PI-3K) by wortmannin or LY294002 as well as the inhibition of MEK by PD098059 or U0126 prevented the protective effect of VEGF and EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	31-42
14578214-7	2004	Similar results were obtained in rats in vivo, where Ly294002 prevented NF-kappaB activation by overventilation but not by endotoxin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	nuclear factor kappa B subunit 1	Homo sapiens	72-81
14698040-9	2004	Furthermore, the inhibition of PI-3 kinase (PI-3K) by wortmannin or LY294002 as well as the inhibition of MEK by PD098059 or U0126 prevented the protective effect of VEGF and EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	vascular endothelial growth factor A	Homo sapiens	166-170
15679045-10	2004	Exposure to LY294002 significantly decreased both CSF-1 and Dex-induced adhesiveness to the level of control cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	colony stimulating factor 1	Homo sapiens	50-55
14557259-7	2004	Dominant-negative Akt or the phosphatidylinositol 3-kinase inhibitor LY294002 blocked adiponectin-stimulated Akt and eNOS phosphorylation, migration, and differentiation without altering AMPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	adiponectin, C1Q and collagen domain containing	Homo sapiens	86-97
14557259-7	2004	Dominant-negative Akt or the phosphatidylinositol 3-kinase inhibitor LY294002 blocked adiponectin-stimulated Akt and eNOS phosphorylation, migration, and differentiation without altering AMPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	109-112
14712206-6	2004	The specific PI3K inhibitor LY294002 inhibits PI3K/Akt signaling and potentiates the radiation-induced apoptosis, suggesting that activation of the PI3K/Akt signaling pathway is involved in the increased radio-resistance in cells overexpressing 12V-Ha-Ras.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	51-54
14712206-6	2004	The specific PI3K inhibitor LY294002 inhibits PI3K/Akt signaling and potentiates the radiation-induced apoptosis, suggesting that activation of the PI3K/Akt signaling pathway is involved in the increased radio-resistance in cells overexpressing 12V-Ha-Ras.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	153-156
14691048-13	2004	The ERK1/2 activation is dependent on PI3K pathway, because protein kinase B was phosphorylated by PAF and inhibited by wortmannin and LY294002, but not by U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	mitogen-activated protein kinase 3	Bos taurus	4-10
14691048-13	2004	The ERK1/2 activation is dependent on PI3K pathway, because protein kinase B was phosphorylated by PAF and inhibited by wortmannin and LY294002, but not by U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	PCNA-associated factor	Bos taurus	99-102
14512432-9	2004	In contrast, the PI3-kinase inhibitor LY294002 completely blocked insulin-stimulated 17alpha-hydroxylase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	insulin	Homo sapiens	66-73
14729104-7	2004	The phosphatidylinositol 3-kinase (PI-3K) inhibitors wortmannin and LY 294002 ((2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one) inhibited H(2)O(2)-induced increases in ERK1/2 and PKB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-128	mitogen-activated protein kinase 3	Homo sapiens	170-176
14729104-7	2004	The phosphatidylinositol 3-kinase (PI-3K) inhibitors wortmannin and LY 294002 ((2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one) inhibited H(2)O(2)-induced increases in ERK1/2 and PKB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-128	protein tyrosine kinase 2 beta	Homo sapiens	181-184
14691048-12	2004	PAF MAPK activation was also inhibited by WEB2086, pertussis toxin (PTX), genistein, wortmannin, LY294002, PD98059 and UO126 in bovine neutrophils.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	PCNA-associated factor	Bos taurus	0-3
14691048-12	2004	PAF MAPK activation was also inhibited by WEB2086, pertussis toxin (PTX), genistein, wortmannin, LY294002, PD98059 and UO126 in bovine neutrophils.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	mitogen-activated protein kinase 1	Bos taurus	4-8
14500571-7	2004	E2 inhibited the paclitaxel-induced JNK activation, and the E2-induced inhibition of the paclitaxel-induced JNK activation was attenuated in cells treated with either ICI182,780 or LY294002 or transfected with ASK1S83A, in which a consensus Akt phosphorylation site at serine-83 was converted to alanine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	mitogen-activated protein kinase 8	Homo sapiens	108-111
14500571-7	2004	E2 inhibited the paclitaxel-induced JNK activation, and the E2-induced inhibition of the paclitaxel-induced JNK activation was attenuated in cells treated with either ICI182,780 or LY294002 or transfected with ASK1S83A, in which a consensus Akt phosphorylation site at serine-83 was converted to alanine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	AKT serine/threonine kinase 1	Homo sapiens	241-244
14725899-8	2004	The PI3 kinase inhibitors LY294002 and wortmannin substituted for G-CSF in combination with IL-3 since proliferation in the presence of LY294002/wortmannin+IL-3 was enhanced to the same extent as in the presence of G-CSF+IL-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	interleukin 3	Homo sapiens	92-96
14725899-8	2004	The PI3 kinase inhibitors LY294002 and wortmannin substituted for G-CSF in combination with IL-3 since proliferation in the presence of LY294002/wortmannin+IL-3 was enhanced to the same extent as in the presence of G-CSF+IL-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	interleukin 3	Homo sapiens	156-160
14725899-8	2004	The PI3 kinase inhibitors LY294002 and wortmannin substituted for G-CSF in combination with IL-3 since proliferation in the presence of LY294002/wortmannin+IL-3 was enhanced to the same extent as in the presence of G-CSF+IL-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	colony stimulating factor 3	Homo sapiens	215-220
14725899-8	2004	The PI3 kinase inhibitors LY294002 and wortmannin substituted for G-CSF in combination with IL-3 since proliferation in the presence of LY294002/wortmannin+IL-3 was enhanced to the same extent as in the presence of G-CSF+IL-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	interleukin 3	Homo sapiens	156-160
14725899-8	2004	The PI3 kinase inhibitors LY294002 and wortmannin substituted for G-CSF in combination with IL-3 since proliferation in the presence of LY294002/wortmannin+IL-3 was enhanced to the same extent as in the presence of G-CSF+IL-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	colony stimulating factor 3	Homo sapiens	66-71
14725899-8	2004	The PI3 kinase inhibitors LY294002 and wortmannin substituted for G-CSF in combination with IL-3 since proliferation in the presence of LY294002/wortmannin+IL-3 was enhanced to the same extent as in the presence of G-CSF+IL-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	interleukin 3	Homo sapiens	92-96
14725899-8	2004	The PI3 kinase inhibitors LY294002 and wortmannin substituted for G-CSF in combination with IL-3 since proliferation in the presence of LY294002/wortmannin+IL-3 was enhanced to the same extent as in the presence of G-CSF+IL-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	colony stimulating factor 3	Homo sapiens	215-220
14725899-9	2004	In contrast, LY294002 and wortmannin inhibited proliferation in the presence of EPO and in the presence of EPO+IL-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	erythropoietin	Homo sapiens	80-83
14725899-9	2004	In contrast, LY294002 and wortmannin inhibited proliferation in the presence of EPO and in the presence of EPO+IL-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	erythropoietin	Homo sapiens	107-110
14725899-9	2004	In contrast, LY294002 and wortmannin inhibited proliferation in the presence of EPO and in the presence of EPO+IL-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	interleukin 3	Homo sapiens	111-115
15541884-5	2004	These measurements showed that estradiol increased phosphorylation of CREB (cyclic AMP response-element binding protein), which was consistently blocked by the ERK pathway inhibitor PD98059 but not by the inhibitors of phosphatidylinositol 3-kinase, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	265-273	cAMP responsive element binding protein 1	Rattus norvegicus	70-74
15456937-7	2004	Because PI3 kinase is a potential upstream regulator of cPKC, its inhibition by wortmannin or LY294002 also abolished the lithium-induced serine phosphorylation of GSK-3beta in HEK293 and PC12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	glycogen synthase kinase 3 beta	Homo sapiens	164-173
14574326-6	2004	The PI3-K inhibitor Ly294002 and the Ras inhibitor L-744832 both inhibited PKB phosphorylation and NF-kappaB DNA-binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	protein tyrosine kinase 2 beta	Homo sapiens	75-78
14605879-3	2004	Thus, we postulated that LY294002, a PI3 K inhibitor, should inactivate Akt, consequently inhibiting cell proliferation and increase apoptosis in the human gastric carcinoma cell line, MKN-45.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	72-75
14605879-5	2004	LY294002 caused a decrease of phosphorylated-Akt and an inhibition of cell proliferation via cell cycle arrest in the G0/G1 phase by P27/Kip1 accumulation, but there was no obvious induction of apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	45-48
14605879-5	2004	LY294002 caused a decrease of phosphorylated-Akt and an inhibition of cell proliferation via cell cycle arrest in the G0/G1 phase by P27/Kip1 accumulation, but there was no obvious induction of apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interferon alpha inducible protein 27	Homo sapiens	133-136
14605879-5	2004	LY294002 caused a decrease of phosphorylated-Akt and an inhibition of cell proliferation via cell cycle arrest in the G0/G1 phase by P27/Kip1 accumulation, but there was no obvious induction of apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	137-141
14605879-7	2004	Decreased phosphorylated-Akt by LY294002 treatment led to a down-regulation of Mcl-2 and phosphorylated Bad proteins, which are anti-apoptotic factors and belong to the Bcl-2 family.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	25-28
14605879-7	2004	Decreased phosphorylated-Akt by LY294002 treatment led to a down-regulation of Mcl-2 and phosphorylated Bad proteins, which are anti-apoptotic factors and belong to the Bcl-2 family.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	BCL2 apoptosis regulator	Homo sapiens	169-174
14605879-9	2004	We concluded that: 1) the PI3K-Akt pathway plays an important role in preventing Fas-mediated apoptosis; and 2) a PI3 K inhibitor, such as LY294002, might be a useful anti-tumoral agent for gastric carcinoma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Homo sapiens	31-34
14690534-3	2004	Northern blot analysis and RT-PCR showed that treatment with 10 nm IGF-1 increased the UCP3 mRNA levels 2.5-fold after 5 h. Co-incubation with the phosphatidylinositol 3 (PI3)-kinase inhibitor LY294002 prohibited IGF-1-mediated induction of both UCP3 mRNA and protein in a concentration-dependent manner, with a complete blockage at 1 microm, as shown by RT-PCR and western blot analyses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	insulin like growth factor 1	Homo sapiens	67-72
14690534-3	2004	Northern blot analysis and RT-PCR showed that treatment with 10 nm IGF-1 increased the UCP3 mRNA levels 2.5-fold after 5 h. Co-incubation with the phosphatidylinositol 3 (PI3)-kinase inhibitor LY294002 prohibited IGF-1-mediated induction of both UCP3 mRNA and protein in a concentration-dependent manner, with a complete blockage at 1 microm, as shown by RT-PCR and western blot analyses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	uncoupling protein 3	Homo sapiens	87-91
14694442-5	2004	A selective inhibitor of Akt phosphorylation, LY294002, accelerated formation of the death-inducing signaling complex (DISC) not only by FLIP reduction but also by enhancement of recruitment of the FADD to Fas, thereby sensitizing PC3 cells to apoptosis similar to the case with 2-ME stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	25-28
15541884-5	2004	These measurements showed that estradiol increased phosphorylation of CREB (cyclic AMP response-element binding protein), which was consistently blocked by the ERK pathway inhibitor PD98059 but not by the inhibitors of phosphatidylinositol 3-kinase, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	265-273	cAMP responsive element binding protein 1	Rattus norvegicus	76-119
15541884-5	2004	These measurements showed that estradiol increased phosphorylation of CREB (cyclic AMP response-element binding protein), which was consistently blocked by the ERK pathway inhibitor PD98059 but not by the inhibitors of phosphatidylinositol 3-kinase, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	265-273	mitogen activated protein kinase 3	Rattus norvegicus	160-163
15545011-6	2004	Incubation with, Ro-31-8220 rescued neurons from cell death induced by the PI 3-K inhibitor, LY294002, suggesting that Ro-31-8220 may affect Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Homo sapiens	141-144
15545011-7	2004	Western blot analysis showed that serum-free, low potassium conditions decreased Akt phosphorylation, which was exacerbated by treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	AKT serine/threonine kinase 1	Homo sapiens	81-84
14522959-8	2003	Moreover, Akt activation can be normally stimulated by treatment with insulin growth factor-1 and blocked by treatment with the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	thymoma viral proto-oncogene 1	Mus musculus	10-13
14654170-6	2003	After the inhibition of protein kinase B (Akt) by LY294002 or p38 mitogen-activated protein kinase (p38MAPK) by SB203580, the addition of TNF-alpha did not cause apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	thymoma viral proto-oncogene 1	Mus musculus	42-45
12933576-8	2003	The inhibitors of phosphatidylinositol-3 kinase, wortmannin and LY294002, suppressed ABIN-2 inhibition of endothelial cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	TNFAIP3 interacting protein 2	Homo sapiens	85-91
14514674-7	2003	We demonstrate that phosphatidylinositol 3-kinase inhibitor Ly294002 and the p85 dominant negative mutant can block NRP-1-mediated HUVEC migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	neuropilin 1	Homo sapiens	116-121
14637151-6	2003	The use of not PD98059 but LY294002 abrogated PDGF-mediated inhibitory effect toward TRAIL-induced apoptosis in synovial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	TNF superfamily member 10	Homo sapiens	85-90
14615286-7	2003	ACh exposure increased phosphorylation (Ser473) of protein kinase B (Akt), and this effect was blocked by LY294002 and unaffected in low (0.5 mmol/L) [Ca2+]o. Confocal microscopy revealed that ACh exposure increased NOi at local subsarcolemmal sites, and ACh withdrawal additionally increased NOi by recruiting additional subsarcolemmal release sites.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	AKT serine/threonine kinase 1	Homo sapiens	69-72
14637151-4	2003	TRAIL-mediated apoptosis in synovial cells was significantly increased through inactivation of Akt by LY294002, however, that process was not so changed by adding ERK inhibitor, PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	TNF superfamily member 10	Homo sapiens	0-5
14637151-4	2003	TRAIL-mediated apoptosis in synovial cells was significantly increased through inactivation of Akt by LY294002, however, that process was not so changed by adding ERK inhibitor, PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	AKT serine/threonine kinase 1	Homo sapiens	95-98
14517212-6	2003	The phosphatidylinositol (PI) 3-kinase inhibitor LY 294002 and the Src kinase inhibitor PP2 partially occluded the response but also decreased basal levels of phospho-ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-58	mitogen-activated protein kinase 1	Mus musculus	167-170
14517212-8	2003	LY 294002 decreased the number of viable cells after 18 h of treatment; therefore, the inhibition of ERK by this inhibitor is probably because of cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	mitogen-activated protein kinase 1	Mus musculus	101-104
14639124-6	2003	This activation was phosphatidylinositol 3 (PI3)-kinase-dependent and promoted survival of Caco-2 cells because the PI3 kinase inhibitor LY294002 inhibited the Akt/PKB activation and induced apoptosis of Caco-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	AKT serine/threonine kinase 1	Homo sapiens	160-163
14685150-11	2003	The modulated cells contained a cortical actin ring while LY294002 completely abolished this action of FGF-2 on actin cytoskeleton.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	fibroblast growth factor 2	Homo sapiens	103-108
14685150-19	2003	Both neutralizing antibody to FGF-2 and LY294002 completely impeded the modulating activity of FGF-2 on the endothelial monolayer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	fibroblast growth factor 2	Homo sapiens	95-100
14685150-21	2003	Both LY294002 and neutralizing antibody to FGF-2 antagonized the actions of FGF-2 and Y27632.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	fibroblast growth factor 2	Homo sapiens	76-81
12960025-6	2003	The cytosolic accumulation of FKHR protein that was observed in FSH-treated cells both by Western blot and immunohistochemistry was blocked when the cells were preincubated with the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	222-230	forkhead box O1	Homo sapiens	30-34
14662022-6	2003	Treatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 or with the protein synthesis inhibitor cycloheximide induced a suppression of constitutive Akt activation in SNU-216 cells and a concomitant decrease in the expression of FLIP(S).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	167-170
14662022-7	2003	The reduction of Akt activity by LY294002 affected the transcriptional level of FLIP(S), but not the mRNA stability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Homo sapiens	17-20
14662022-8	2003	As a result, LY294002 or cycloheximide significantly enhanced TRAIL-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	TNF superfamily member 10	Homo sapiens	62-67
14575867-2	2003	We demonstrate the involvement of phosphoinositide 3-kinase (PI3-K) in Xenopus and Labrus aggregation by the use of the PI3-K inhibitor, LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-146	phosphoinositide-3-kinase regulatory subunit 1 S homeolog	Xenopus laevis	34-59
14639124-6	2003	This activation was phosphatidylinositol 3 (PI3)-kinase-dependent and promoted survival of Caco-2 cells because the PI3 kinase inhibitor LY294002 inhibited the Akt/PKB activation and induced apoptosis of Caco-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	AKT serine/threonine kinase 1	Homo sapiens	164-167
14612947-6	2003	Similarly, inhibition of PI3K activation by its specific inhibitor LY294002 suppressed Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	thymoma viral proto-oncogene 1	Mus musculus	87-90
14645153-2	2003	We show in the present work that phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 prevent TCR/CD3-induced functional Fas ligand (FasL) expression, but not perforin-dependent cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	113-116
14645153-2	2003	We show in the present work that phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 prevent TCR/CD3-induced functional Fas ligand (FasL) expression, but not perforin-dependent cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	Fas ligand	Homo sapiens	140-150
14645153-2	2003	We show in the present work that phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 prevent TCR/CD3-induced functional Fas ligand (FasL) expression, but not perforin-dependent cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	Fas ligand	Homo sapiens	152-156
14704034-4	2003	Treating ECFCs with a high concentration of Ly294002 (50 micromol/L) in the presence of EPO and/or IFN-gamma reduced cell viability by inducing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	erythropoietin	Homo sapiens	88-91
14704034-4	2003	Treating ECFCs with a high concentration of Ly294002 (50 micromol/L) in the presence of EPO and/or IFN-gamma reduced cell viability by inducing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	interferon gamma	Homo sapiens	99-108
14704034-5	2003	However, treating cells with a lower concentration of Ly294002 (10 micromol/L) did not affect the antiapoptotic function of IFN-gamma and abolished the antiapoptotic effect of EPO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	erythropoietin	Homo sapiens	176-179
14704034-6	2003	Adding IFN-gamma or EPO induced Bcl-x expression in ECFCs, as determined by Western blotting, and expression was suppressed in the presence of Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	interferon gamma	Homo sapiens	7-16
14704034-6	2003	Adding IFN-gamma or EPO induced Bcl-x expression in ECFCs, as determined by Western blotting, and expression was suppressed in the presence of Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	erythropoietin	Homo sapiens	20-23
14704034-6	2003	Adding IFN-gamma or EPO induced Bcl-x expression in ECFCs, as determined by Western blotting, and expression was suppressed in the presence of Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	BCL2 like 1	Homo sapiens	32-37
14625085-8	2003	In addition, LY294002, a specific inhibitor of PI3-K, cancelled the inhibitory effects of BDNF and IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	brain-derived neurotrophic factor	Rattus norvegicus	90-94
12960228-7	2003	Low doses of LY294002, a phosphatidyl-inositol-3-kinase inhibitor, which abolished cell growth and p70S6K activity but did not influence Akt activity, did not block the insulin-mediated rescue either.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	ribosomal protein S6 kinase B1	Homo sapiens	99-105
13679518-6	2003	The Nef-induced up-regulation of surface Ii chain was inhibited by LY294002 exposure, indicating the involvement of a phosphatidylinositol 3-kinase, whose products play a key role in MVB biogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	S100 calcium binding protein B	Homo sapiens	4-7
12930919-6	2003	In contrast, LY294002 was additive in the IGF-I-induced up-regulation of MHC class II.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	insulin like growth factor 1	Homo sapiens	42-47
14635227-10	2003	Cell motility in HGF/SF treated cultures was inhibited by LY294002 but not by PD98059, suggesting that PI3-K plays a key role in mediating the HGF/SF-induced dissociation of ST14A cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	hepatocyte growth factor	Rattus norvegicus	17-23
14635227-10	2003	Cell motility in HGF/SF treated cultures was inhibited by LY294002 but not by PD98059, suggesting that PI3-K plays a key role in mediating the HGF/SF-induced dissociation of ST14A cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	hepatocyte growth factor	Rattus norvegicus	143-149
14645548-7	2003	We demonstrate that increased Akt activities are largely responsible for cav-1-mediated cell survival using dominant-negative Akt mutants and specific inhibitors to MEK1/MEK and show that cav-1 increases the half-life of phosphorylated PDK1 and Akt after inhibition of PI3-K by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	278-286	AKT serine/threonine kinase 1	Homo sapiens	30-33
14645548-7	2003	We demonstrate that increased Akt activities are largely responsible for cav-1-mediated cell survival using dominant-negative Akt mutants and specific inhibitors to MEK1/MEK and show that cav-1 increases the half-life of phosphorylated PDK1 and Akt after inhibition of PI3-K by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	278-286	caveolin 1	Homo sapiens	73-78
14645548-7	2003	We demonstrate that increased Akt activities are largely responsible for cav-1-mediated cell survival using dominant-negative Akt mutants and specific inhibitors to MEK1/MEK and show that cav-1 increases the half-life of phosphorylated PDK1 and Akt after inhibition of PI3-K by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	278-286	caveolin 1	Homo sapiens	188-193
14645548-7	2003	We demonstrate that increased Akt activities are largely responsible for cav-1-mediated cell survival using dominant-negative Akt mutants and specific inhibitors to MEK1/MEK and show that cav-1 increases the half-life of phosphorylated PDK1 and Akt after inhibition of PI3-K by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	278-286	pyruvate dehydrogenase kinase 1	Homo sapiens	236-240
14625550-9	2003	High ABI in all cell lines was suppressed by mTOR inhibitors LY294002 and rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	mechanistic target of rapamycin kinase	Mus musculus	45-49
14642780-7	2003	LY294002 thereby inhibited LPS/IFN-induced iNOS expression and NO production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 2	Homo sapiens	43-47
14625085-8	2003	In addition, LY294002, a specific inhibitor of PI3-K, cancelled the inhibitory effects of BDNF and IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	insulin-like growth factor 1	Rattus norvegicus	99-104
14599555-4	2003	Reversal of TNF-alpha/ATA effects occurred in the presence of the PI-3K specific inhibitors wortmannin or LY294002 in the culture medium and was coincident with inhibition of the translocation of PKCzeta in the nucleus, while NF-kappaB was less affected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	tumor necrosis factor	Homo sapiens	12-21
14597408-0	2003	Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	NK2 homeobox 5	Mus musculus	84-87
14599555-4	2003	Reversal of TNF-alpha/ATA effects occurred in the presence of the PI-3K specific inhibitors wortmannin or LY294002 in the culture medium and was coincident with inhibition of the translocation of PKCzeta in the nucleus, while NF-kappaB was less affected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	protein kinase C zeta	Homo sapiens	196-203
14597408-0	2003	Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	NK2 homeobox 5	Mus musculus	88-95
14597408-0	2003	Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	GATA binding protein 4	Mus musculus	100-106
12952968-12	2003	However, adenovirus-mediated overexpression of constitutively active Akt completely blocked UV-induced apoptosis observed with PI3K inhibition by LY294002, whereas adenovirus mediated overexpression of dominant negative Akt increased UV-induced apoptosis by 2-fold.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	AKT serine/threonine kinase 1	Homo sapiens	69-72
14597408-9	2003	LY294002 treatment from days 0 to 4 also suppressed Csx/Nkx-2.5 and GATA-4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	NK2 homeobox 5	Mus musculus	52-55
14597408-9	2003	LY294002 treatment from days 0 to 4 also suppressed Csx/Nkx-2.5 and GATA-4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	NK2 homeobox 5	Mus musculus	56-63
14597408-9	2003	LY294002 treatment from days 0 to 4 also suppressed Csx/Nkx-2.5 and GATA-4 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	GATA binding protein 4	Mus musculus	68-74
14551245-10	2003	We found that the motogenic effect of NO, Gab1, and SHP2 was blocked by the selective PI3 kinase inhibitor LY294002, suggesting a requirement of PI3 kinase in mediating motogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	GRB2-associated binding protein 1	Rattus norvegicus	42-46
14551245-10	2003	We found that the motogenic effect of NO, Gab1, and SHP2 was blocked by the selective PI3 kinase inhibitor LY294002, suggesting a requirement of PI3 kinase in mediating motogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	52-56
12876075-7	2003	An inhibitor of the phosphatidylinositol 3-kinase pathway, LY-294002, blocked both insulin- and Akt-induced inhibition of protein degradation, again consistent with the hypothesis that both agents were acting on the same pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	insulin	Homo sapiens	83-90
12876075-7	2003	An inhibitor of the phosphatidylinositol 3-kinase pathway, LY-294002, blocked both insulin- and Akt-induced inhibition of protein degradation, again consistent with the hypothesis that both agents were acting on the same pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-68	AKT serine/threonine kinase 1	Homo sapiens	96-99
14500543-6	2003	The RANKL-induced survival appeared to be dependent on PI 3"-kinase activity, because wortmannin and LY294002, PI 3"-kinase-specific inhibitors, blocked the RANKL-induced survival effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	TNF superfamily member 11	Homo sapiens	4-9
12969991-9	2003	LY294002, a PI3K inhibitor, and N-acetylcysteine, a scavenger of reactive oxygen species, inhibited the stretch activation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	126-129
14500293-7	2003	In a chemotaxis assay, the PI3 kinase-specific inhibitor LY294002 blocked the migratory response of HUVECs induced by addition of ephrin-B2/Fc.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	ephrin B2	Mus musculus	130-139
14500293-8	2003	Finally, ephrin-B2/Fc promoted angiogenesis in vivo in corneal neovascularization and Matrigel plug assays in adult mice, whereas LY294002 reduced angiogenesis in Matrigel that was induced by ephrin-B2/Fc.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	ephrin B2	Mus musculus	192-201
12855588-5	2003	c-myc IRES activation, c-Myc protein expression, and cell cycle progression were all blocked by a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
12855588-5	2003	c-myc IRES activation, c-Myc protein expression, and cell cycle progression were all blocked by a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	23-28
12855588-6	2003	In another factor-dependent cell line, UT7, we observed the cell cycle progression and up-regulation of c-Myc protein, c-myc mRNA, and c-myc IRES simultaneously, which were all inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	104-109
12855588-6	2003	In another factor-dependent cell line, UT7, we observed the cell cycle progression and up-regulation of c-Myc protein, c-myc mRNA, and c-myc IRES simultaneously, which were all inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	119-124
12855588-6	2003	In another factor-dependent cell line, UT7, we observed the cell cycle progression and up-regulation of c-Myc protein, c-myc mRNA, and c-myc IRES simultaneously, which were all inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	135-140
14500543-6	2003	The RANKL-induced survival appeared to be dependent on PI 3"-kinase activity, because wortmannin and LY294002, PI 3"-kinase-specific inhibitors, blocked the RANKL-induced survival effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	TNF superfamily member 11	Homo sapiens	157-162
13130092-10	2003	Treatment of migrating cells with a specific inhibitor of phosphoinositide 3-kinase (PI3-K), LY294002, blocked the phosphorylation of Akt and increased the sensitivity to apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	58-83
14710346-9	2003	Selective inhibitors LY294002 or PD98059 were highly effective in reducing the ability of ES cells to produce VEGF-A and stimulate survival and proliferation of HUVECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	vascular endothelial growth factor A	Homo sapiens	110-116
13130092-10	2003	Treatment of migrating cells with a specific inhibitor of phosphoinositide 3-kinase (PI3-K), LY294002, blocked the phosphorylation of Akt and increased the sensitivity to apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Homo sapiens	134-137
14596677-5	2003	The insulin-induced suppression of IRS-2 mRNA and protein was blocked by the phosphatidylinositol (PI) 3-kinase inhibitor, LY294002, but not by the MAP kinase-ERK kinase (MEK) inhibitor, PD098059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	insulin	Homo sapiens	4-11
14602779-7	2003	The IGF-I-induced up-regulation of VEGF production was associated with activation of AP-1 and HIF-1 alpha and was abrogated by phosphatidylinositol 3-kinase inhibitors (wortmannin and LY294002); Jun kinase inhibitor (SP600125); HIF-1 alpha antisense oligonucleotide; or geldanamycin, an inhibitor of the heat shock protein 90 molecular chaperone, which regulates the three-dimensional conformation and function of IGF-I-receptor and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	insulin like growth factor 1	Homo sapiens	4-9
14602779-7	2003	The IGF-I-induced up-regulation of VEGF production was associated with activation of AP-1 and HIF-1 alpha and was abrogated by phosphatidylinositol 3-kinase inhibitors (wortmannin and LY294002); Jun kinase inhibitor (SP600125); HIF-1 alpha antisense oligonucleotide; or geldanamycin, an inhibitor of the heat shock protein 90 molecular chaperone, which regulates the three-dimensional conformation and function of IGF-I-receptor and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	vascular endothelial growth factor A	Homo sapiens	35-39
14602779-7	2003	The IGF-I-induced up-regulation of VEGF production was associated with activation of AP-1 and HIF-1 alpha and was abrogated by phosphatidylinositol 3-kinase inhibitors (wortmannin and LY294002); Jun kinase inhibitor (SP600125); HIF-1 alpha antisense oligonucleotide; or geldanamycin, an inhibitor of the heat shock protein 90 molecular chaperone, which regulates the three-dimensional conformation and function of IGF-I-receptor and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	85-89
14602779-7	2003	The IGF-I-induced up-regulation of VEGF production was associated with activation of AP-1 and HIF-1 alpha and was abrogated by phosphatidylinositol 3-kinase inhibitors (wortmannin and LY294002); Jun kinase inhibitor (SP600125); HIF-1 alpha antisense oligonucleotide; or geldanamycin, an inhibitor of the heat shock protein 90 molecular chaperone, which regulates the three-dimensional conformation and function of IGF-I-receptor and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-105
14602779-7	2003	The IGF-I-induced up-regulation of VEGF production was associated with activation of AP-1 and HIF-1 alpha and was abrogated by phosphatidylinositol 3-kinase inhibitors (wortmannin and LY294002); Jun kinase inhibitor (SP600125); HIF-1 alpha antisense oligonucleotide; or geldanamycin, an inhibitor of the heat shock protein 90 molecular chaperone, which regulates the three-dimensional conformation and function of IGF-I-receptor and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	hypoxia inducible factor 1 subunit alpha	Homo sapiens	228-239
14602779-7	2003	The IGF-I-induced up-regulation of VEGF production was associated with activation of AP-1 and HIF-1 alpha and was abrogated by phosphatidylinositol 3-kinase inhibitors (wortmannin and LY294002); Jun kinase inhibitor (SP600125); HIF-1 alpha antisense oligonucleotide; or geldanamycin, an inhibitor of the heat shock protein 90 molecular chaperone, which regulates the three-dimensional conformation and function of IGF-I-receptor and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	insulin like growth factor 1 receptor	Homo sapiens	414-428
14602779-7	2003	The IGF-I-induced up-regulation of VEGF production was associated with activation of AP-1 and HIF-1 alpha and was abrogated by phosphatidylinositol 3-kinase inhibitors (wortmannin and LY294002); Jun kinase inhibitor (SP600125); HIF-1 alpha antisense oligonucleotide; or geldanamycin, an inhibitor of the heat shock protein 90 molecular chaperone, which regulates the three-dimensional conformation and function of IGF-I-receptor and Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	AKT serine/threonine kinase 1	Homo sapiens	433-436
12960281-4	2003	The inhibitor LY294002 was able to completely abolish survival mediated by KL, whereas IL-3 and FL were only partially affected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	kit ligand	Mus musculus	75-77
14596677-5	2003	The insulin-induced suppression of IRS-2 mRNA and protein was blocked by the phosphatidylinositol (PI) 3-kinase inhibitor, LY294002, but not by the MAP kinase-ERK kinase (MEK) inhibitor, PD098059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	insulin receptor substrate 2	Rattus norvegicus	35-40
12907754-8	2003	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 abolished cell proliferation and activation of p70S6K and Akt; however, PRL-dependent activation of Erk1/2 was not modified.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-33
12904331-6	2003	The residual increase in firing rate produced by Ang II in SHR neurons was blocked by inhibitors of phosphatidylinositol 3 kinase (PI3-kinase), either LY 294002 (10 microM) or wortmannin (100 nM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-160	angiotensinogen	Rattus norvegicus	49-55
12970762-3	2003	Inhibition of phosphatidylinositol-3 kinase (PI3K) with LY294002 and of the mitogen-activated protein kinase (MAPK) cascade by PD98059 resulted in decreased XIAP levels (34+/-8.7 and 23+/-5.7%, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	14-43
12970762-3	2003	Inhibition of phosphatidylinositol-3 kinase (PI3K) with LY294002 and of the mitogen-activated protein kinase (MAPK) cascade by PD98059 resulted in decreased XIAP levels (34+/-8.7 and 23+/-5.7%, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	X-linked inhibitor of apoptosis	Homo sapiens	157-161
14596794-10	2003	LY294002, a specific inhibitor of phosphoinositide 3 kinase (PI3 kinase), blunted the phosphorylation of AKT and inhibited LPC induction of RANTES more strongly than IL-8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	105-108
14596794-10	2003	LY294002, a specific inhibitor of phosphoinositide 3 kinase (PI3 kinase), blunted the phosphorylation of AKT and inhibited LPC induction of RANTES more strongly than IL-8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-C motif chemokine ligand 5	Homo sapiens	140-146
14622133-5	2003	Blockade of Akt with PI3-kinase inhibitor, LY294002, lowered basal P-gp and prevented the H2O2-induced increase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Rattus norvegicus	12-15
12907754-8	2003	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 abolished cell proliferation and activation of p70S6K and Akt; however, PRL-dependent activation of Erk1/2 was not modified.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	ribosomal protein S6 kinase B1	Homo sapiens	107-113
12907754-8	2003	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 abolished cell proliferation and activation of p70S6K and Akt; however, PRL-dependent activation of Erk1/2 was not modified.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	118-121
14561494-7	2003	The insulin-dependent stimulation of K(ATP) channel was prevented by Pi-3 kinase inhibitors Wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	insulin	Homo sapiens	4-11
14585967-6	2003	Degradation of IkappaBalpha is partially blocked by phosphatidylinositol 3-kinase inhibitor LY294002 and is mediated by the proteasome.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	15-27
14617784-7	2003	When specific inhibitors of the phosphatidylinositol 3-kinase (PI3-K) and MAPK kinase (MEK) pathways were used, we found that exposure of MCF7HER2 cells to the PI3-K inhibitor LY294002 inhibited Akt phosphorylation and radiosensitized the cells, whereas the radiosensitization effect by the MEK inhibitor PD98059 was relatively weaker, albeit the phosphorylation of MAPK was reduced by PD98059 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	32-61
14617784-7	2003	When specific inhibitors of the phosphatidylinositol 3-kinase (PI3-K) and MAPK kinase (MEK) pathways were used, we found that exposure of MCF7HER2 cells to the PI3-K inhibitor LY294002 inhibited Akt phosphorylation and radiosensitized the cells, whereas the radiosensitization effect by the MEK inhibitor PD98059 was relatively weaker, albeit the phosphorylation of MAPK was reduced by PD98059 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	mitogen-activated protein kinase kinase 7	Homo sapiens	87-90
14617784-7	2003	When specific inhibitors of the phosphatidylinositol 3-kinase (PI3-K) and MAPK kinase (MEK) pathways were used, we found that exposure of MCF7HER2 cells to the PI3-K inhibitor LY294002 inhibited Akt phosphorylation and radiosensitized the cells, whereas the radiosensitization effect by the MEK inhibitor PD98059 was relatively weaker, albeit the phosphorylation of MAPK was reduced by PD98059 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	AKT serine/threonine kinase 1	Homo sapiens	195-198
14617784-7	2003	When specific inhibitors of the phosphatidylinositol 3-kinase (PI3-K) and MAPK kinase (MEK) pathways were used, we found that exposure of MCF7HER2 cells to the PI3-K inhibitor LY294002 inhibited Akt phosphorylation and radiosensitized the cells, whereas the radiosensitization effect by the MEK inhibitor PD98059 was relatively weaker, albeit the phosphorylation of MAPK was reduced by PD98059 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	mitogen-activated protein kinase kinase 7	Homo sapiens	291-294
12917431-5	2003	E2 induced the phosphorylation of Akt, and pretreatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, attenuated the E2-induced increases of the telomerase activity and hTERT promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Homo sapiens	34-37
12904602-9	2003	Moreover, doxorubicin, NF-kappaB inhibitor (SN50), and PI3-kinase/Akt inhibitor (wortmannin, LY294002) enhanced the susceptibility of MRT cell lines to TRAIL/Apo2L-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	TNF superfamily member 10	Homo sapiens	152-157
12904602-9	2003	Moreover, doxorubicin, NF-kappaB inhibitor (SN50), and PI3-kinase/Akt inhibitor (wortmannin, LY294002) enhanced the susceptibility of MRT cell lines to TRAIL/Apo2L-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	TNF superfamily member 10	Homo sapiens	158-163
12904602-9	2003	Moreover, doxorubicin, NF-kappaB inhibitor (SN50), and PI3-kinase/Akt inhibitor (wortmannin, LY294002) enhanced the susceptibility of MRT cell lines to TRAIL/Apo2L-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	AKT serine/threonine kinase 1	Homo sapiens	66-69
12917431-5	2003	E2 induced the phosphorylation of Akt, and pretreatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, attenuated the E2-induced increases of the telomerase activity and hTERT promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	telomerase reverse transcriptase	Homo sapiens	188-193
14614965-7	2003	NGF increased choroidal endothelial cell migration by 50% over control and this was inhibited by pretreatment with LY294002 (PI3K inhibitor), Akt inhibitor, and MMP2/9 inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	nerve growth factor	Homo sapiens	0-3
14559232-5	2003	The expression of cyclin kinase inhibitor, p21(CIP1/WAF1), was induced by LY294002, while levels of p16(INK4) were decreased in the same experiment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	proliferating cell nuclear antigen	Homo sapiens	18-24
14559232-5	2003	The expression of cyclin kinase inhibitor, p21(CIP1/WAF1), was induced by LY294002, while levels of p16(INK4) were decreased in the same experiment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	cyclin dependent kinase inhibitor 1A	Homo sapiens	43-46
14559232-5	2003	The expression of cyclin kinase inhibitor, p21(CIP1/WAF1), was induced by LY294002, while levels of p16(INK4) were decreased in the same experiment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-51
14559232-5	2003	The expression of cyclin kinase inhibitor, p21(CIP1/WAF1), was induced by LY294002, while levels of p16(INK4) were decreased in the same experiment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	cyclin dependent kinase inhibitor 1A	Homo sapiens	52-56
14614965-9	2003	NGF also produced a 47% increase in choroidal endothelial cell proliferation, which was blocked by PP2, LY294002, Akt inhibitor, KT5823, and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	nerve growth factor	Homo sapiens	0-3
14576824-6	2003	Although treatment with LY294002, a specific inhibitor of PI3 K, decreased the phosphorylation of Akt and increased Fkhr translocation to the nucleus, these events were not sufficient to induce FasL expression and apoptosis of C6 glioma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	AKT serine/threonine kinase 1	Homo sapiens	98-101
12907684-7	2003	The down-regulation of PI 3-kinase and Akt was blocked by CD treatment, and the CD effects on apoptosis, p38 kinase, and PKCalpha and -zeta were abolished by the inhibition of PI 3-kinase with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	mitogen-activated protein kinase 1	Homo sapiens	105-108
12907684-7	2003	The down-regulation of PI 3-kinase and Akt was blocked by CD treatment, and the CD effects on apoptosis, p38 kinase, and PKCalpha and -zeta were abolished by the inhibition of PI 3-kinase with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	protein kinase C alpha	Homo sapiens	121-129
14576824-6	2003	Although treatment with LY294002, a specific inhibitor of PI3 K, decreased the phosphorylation of Akt and increased Fkhr translocation to the nucleus, these events were not sufficient to induce FasL expression and apoptosis of C6 glioma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	forkhead box O1	Homo sapiens	116-120
12907681-9	2003	Addition of the MEK1/2-specific inhibitor U0126 or the PI3K-specific inhibitor LY294002 (but not p38 kinase and JNK inhibitors) completely nullified collagen I-III production and significantly decreased laminin beta2 and fibronectin secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	fibronectin 1	Homo sapiens	221-232
14530366-6	2003	TAT-Deltap85 and LY294002, a PI3K inhibitor, blocked the phosphorylation of gIV-PLA(2) at Ser(505) caused by fMLP, thus inhibiting gIV-PLA(2) hydrolysis and production of AA and LTC(4) in eosinophils.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	formyl peptide receptor 1	Homo sapiens	109-113
12900420-3	2003	In some experiments, LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (a kinase involved in activating Akt) and tumor necrosis factor-alpha (TNF-alpha) were used to activate GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	118-121
12900420-3	2003	In some experiments, LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (a kinase involved in activating Akt) and tumor necrosis factor-alpha (TNF-alpha) were used to activate GSK-3beta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	glycogen synthase kinase 3 beta	Homo sapiens	189-198
14521934-3	2003	Treatment of neurons cultured from neonatal rat hypothalamus and brainstem with Ang II (100 nM) showed a time-dependent increase in AP-1 DNA binding and this effect was inhibited by the AT(1) receptor antagonist, losartan (1 microM), the PI3-K inhibitor, LY294002 (10 microM), and the JNK inhibitor, JNK inhibitor II (100 nM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	255-263	angiotensinogen	Rattus norvegicus	80-86
14521934-3	2003	Treatment of neurons cultured from neonatal rat hypothalamus and brainstem with Ang II (100 nM) showed a time-dependent increase in AP-1 DNA binding and this effect was inhibited by the AT(1) receptor antagonist, losartan (1 microM), the PI3-K inhibitor, LY294002 (10 microM), and the JNK inhibitor, JNK inhibitor II (100 nM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	255-263	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	132-136
14516795-6	2003	While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	ribosomal protein S6 kinase B1	Homo sapiens	126-133
14516795-6	2003	While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	mitogen-activated protein kinase 3	Homo sapiens	136-142
14516795-6	2003	While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	mitogen-activated protein kinase 3	Homo sapiens	282-288
14530366-7	2003	FMLP also caused extracellular signal-related kinases 1 and 2 and p38 MAPK phosphorylation in eosinophils; however, neither phosphorylation of extracellular signal-related kinases 1 and 2 nor p38 was inhibited by TAT-Deltap85 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	formyl peptide receptor 1	Homo sapiens	0-4
12876287-9	2003	Insulin-induced gene expression is inhibited by the presence of the phosphoinositide (PI) 3-kinase inhibitor LY294002 and the dominant negative mutant of the p85 subunit of PI 3-kinase, whereas hypoxia-induced gene expression is not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	insulin	Homo sapiens	0-7
14583467-14	2003	PGE(2) and angiotensin II induced Akt phosphorylation, and LY294002 or wortmannin inhibited PGE(2)- or angiotensin II-induced IGF-IR expression, indicating that PGE(2) and angiotensin II both regulate IGF-IR expression by the same Akt/phosphatidylinositol-3 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	insulin-like growth factor I receptor	Mus musculus	126-132
14583467-14	2003	PGE(2) and angiotensin II induced Akt phosphorylation, and LY294002 or wortmannin inhibited PGE(2)- or angiotensin II-induced IGF-IR expression, indicating that PGE(2) and angiotensin II both regulate IGF-IR expression by the same Akt/phosphatidylinositol-3 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	insulin-like growth factor I receptor	Mus musculus	201-207
14583467-14	2003	PGE(2) and angiotensin II induced Akt phosphorylation, and LY294002 or wortmannin inhibited PGE(2)- or angiotensin II-induced IGF-IR expression, indicating that PGE(2) and angiotensin II both regulate IGF-IR expression by the same Akt/phosphatidylinositol-3 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	thymoma viral proto-oncogene 1	Mus musculus	231-234
12851395-5	2003	Treatment of bone marrow with LY294002, an inhibitor of the Akt effector protein phosphatidylinositol 3-kinase, led to a reversible loss of the SP fraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	thymoma viral proto-oncogene 1	Mus musculus	60-63
12869574-6	2003	Both IL-3 stimulation of transport and GLUT1 translocation were also prevented by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	interleukin 3	Mus musculus	5-9
12869574-6	2003	Both IL-3 stimulation of transport and GLUT1 translocation were also prevented by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	39-44
14550568-2	2003	Phosphorylation of GSK3alpha/beta was dependent on phosphoinositide 3-kinase (PI3K) activity and independent of platelet aggregation, and correlated with a decrease in GSK3 activity that was preserved by pre-incubating platelets with PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	249-257	glycogen synthase kinase 3 alpha	Homo sapiens	19-28
12816861-5	2003	Endothelial cells carrying dominant-negative mutants of RhoA and Rac1 or treated with LY294002, an inhibitor of phosphoinositide 3-OH kinase, dramatically decrease their chemokinetic velocity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	ras homolog family member A	Homo sapiens	56-60
12873705-8	2003	Furthermore, the specific inhibition of the ERK and Akt pathways by PD98059 and LY294002, respectively, restored the cytoprotective effect induced by sphingosine-1-phosphate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	mitogen-activated protein kinase 1	Mus musculus	44-47
12873705-8	2003	Furthermore, the specific inhibition of the ERK and Akt pathways by PD98059 and LY294002, respectively, restored the cytoprotective effect induced by sphingosine-1-phosphate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	thymoma viral proto-oncogene 1	Mus musculus	52-55
14555504-8	2003	We show here that pharmacologic down-regulation of constitutive PI3K/Akt pathway signaling using the PI3K inhibitor LY294002 similarly restores EGFR-stimulated Akt signaling and sensitizes MDA-468 cells to ZD1839.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	69-72
14555504-8	2003	We show here that pharmacologic down-regulation of constitutive PI3K/Akt pathway signaling using the PI3K inhibitor LY294002 similarly restores EGFR-stimulated Akt signaling and sensitizes MDA-468 cells to ZD1839.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	epidermal growth factor receptor	Homo sapiens	144-148
14555504-8	2003	We show here that pharmacologic down-regulation of constitutive PI3K/Akt pathway signaling using the PI3K inhibitor LY294002 similarly restores EGFR-stimulated Akt signaling and sensitizes MDA-468 cells to ZD1839.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	160-163
13679036-6	2003	LY294002, an inhibitor of PI3K, completely blocked AA-induced phosphorylation of Akt, S6K1, ribosomal protein S6, 4EBP1, and eIF4E, suggesting a role for PI3K in these effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	81-84
13679036-6	2003	LY294002, an inhibitor of PI3K, completely blocked AA-induced phosphorylation of Akt, S6K1, ribosomal protein S6, 4EBP1, and eIF4E, suggesting a role for PI3K in these effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribosomal protein S6 kinase B1	Homo sapiens	86-119
13679036-6	2003	LY294002, an inhibitor of PI3K, completely blocked AA-induced phosphorylation of Akt, S6K1, ribosomal protein S6, 4EBP1, and eIF4E, suggesting a role for PI3K in these effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	eukaryotic translation initiation factor 4E	Homo sapiens	125-130
14522084-9	2003	A selective phosphatidylinositol 3-kinase (PI3-kinase) inhibitor (LY294002) blocked 4-hydroxyestradiol-induced Nrf2 nuclear translocation and NQO1 activity induction in IMR-32 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
14522084-9	2003	A selective phosphatidylinositol 3-kinase (PI3-kinase) inhibitor (LY294002) blocked 4-hydroxyestradiol-induced Nrf2 nuclear translocation and NQO1 activity induction in IMR-32 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	NAD(P)H quinone dehydrogenase 1	Homo sapiens	142-146
12896906-5	2003	Serum treatment increased the pErbB3/p85 complexes and also stimulated phosphorylation of Akt and GSK3beta, increase in cyclin D1 and cell cycle progression, and these events were blocked by the Akt activation inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	glycogen synthase kinase 3 beta	Homo sapiens	98-106
12896906-5	2003	Serum treatment increased the pErbB3/p85 complexes and also stimulated phosphorylation of Akt and GSK3beta, increase in cyclin D1 and cell cycle progression, and these events were blocked by the Akt activation inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	cyclin D1	Homo sapiens	120-129
12896906-5	2003	Serum treatment increased the pErbB3/p85 complexes and also stimulated phosphorylation of Akt and GSK3beta, increase in cyclin D1 and cell cycle progression, and these events were blocked by the Akt activation inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	AKT serine/threonine kinase 1	Homo sapiens	195-198
12816861-5	2003	Endothelial cells carrying dominant-negative mutants of RhoA and Rac1 or treated with LY294002, an inhibitor of phosphoinositide 3-OH kinase, dramatically decrease their chemokinetic velocity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	Rac family small GTPase 1	Homo sapiens	65-69
12942541-5	2003	The Ang II-evoked c-fos induction was blocked only by high doses of staurosporine and by zeta-PS whilst PD098059, LY294002 and wortmannin were ineffective, thus indicating that c-fos induction is not due to ERK1/2 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	angiogenin	Homo sapiens	4-7
14507886-5	2003	RESULTS: The PI-3K inhibitors wortmannin and LY294002 blocked the insulin-, insulin-like growth factor (IGF)-1-, and fibroblast growth factor (FGF)-2-promoted cell proliferation in rabbit lens epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	insulin	Gallus gallus	66-73
14507886-5	2003	RESULTS: The PI-3K inhibitors wortmannin and LY294002 blocked the insulin-, insulin-like growth factor (IGF)-1-, and fibroblast growth factor (FGF)-2-promoted cell proliferation in rabbit lens epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	insulin	Gallus gallus	76-83
14507886-5	2003	RESULTS: The PI-3K inhibitors wortmannin and LY294002 blocked the insulin-, insulin-like growth factor (IGF)-1-, and fibroblast growth factor (FGF)-2-promoted cell proliferation in rabbit lens epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	fibroblast growth factor 2	Oryctolagus cuniculus	117-149
12942541-5	2003	The Ang II-evoked c-fos induction was blocked only by high doses of staurosporine and by zeta-PS whilst PD098059, LY294002 and wortmannin were ineffective, thus indicating that c-fos induction is not due to ERK1/2 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-23
12969136-11	2003	Phosphorylation of Akt, FKHR, and FKHRL1 are phosphatidylinositol 3-kinase (PI 3-kinase) dependent since phosphorylation is reduced by the PI 3-kinase inhibitors, wortmannin, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
14632202-3	2003	In this study, we show that LY294002 up-regulates the expression of the melanogenic enzymes, tyrosinase and Tyrp1, through a transcriptional mechanism that involves microphthalmia associated transcription factor, a basic helix-loop-helix transcription factor, which plays a key role in melanocyte survival and differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	tyrosinase	Mus musculus	93-103
14632202-3	2003	In this study, we show that LY294002 up-regulates the expression of the melanogenic enzymes, tyrosinase and Tyrp1, through a transcriptional mechanism that involves microphthalmia associated transcription factor, a basic helix-loop-helix transcription factor, which plays a key role in melanocyte survival and differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	tyrosinase-related protein 1	Mus musculus	108-113
14632202-3	2003	In this study, we show that LY294002 up-regulates the expression of the melanogenic enzymes, tyrosinase and Tyrp1, through a transcriptional mechanism that involves microphthalmia associated transcription factor, a basic helix-loop-helix transcription factor, which plays a key role in melanocyte survival and differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	melanogenesis associated transcription factor	Mus musculus	165-211
14632202-4	2003	Further, we observe that LY294002 increases the intracellular content of microphthalmia associated transcription factor, thereby demonstrating that microphthalmia associated transcription factor is also a convergence point of the phosphatidylinositol-3-kinase signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	melanogenesis associated transcription factor	Mus musculus	73-119
14632202-4	2003	Further, we observe that LY294002 increases the intracellular content of microphthalmia associated transcription factor, thereby demonstrating that microphthalmia associated transcription factor is also a convergence point of the phosphatidylinositol-3-kinase signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	melanogenesis associated transcription factor	Mus musculus	148-194
14632202-5	2003	Finally, our results indicate that LY294002 controls microphthalmia associated transcription factor at the transcriptional level through distal regulatory element that remain to be identified.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	melanogenesis associated transcription factor	Mus musculus	53-99
14521590-9	2003	Thrombin-induced neoangiogenesis was also inhibited to baseline level by agents known to inhibit thrombin receptor signaling in other cells: G-coupled protein receptor inhibitor, pertussis toxin (40 pg per egg), protein kinase C inhibitor, bisindolylmaleimide (1 microm per egg), MAP kinase inhibitor, PD980598 (10 microm per egg) and PI3 kinase inhibitor, LY294002 (0.25 microm per egg).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	357-365	coagulation factor II, thrombin	Gallus gallus	0-8
12969136-11	2003	Phosphorylation of Akt, FKHR, and FKHRL1 are phosphatidylinositol 3-kinase (PI 3-kinase) dependent since phosphorylation is reduced by the PI 3-kinase inhibitors, wortmannin, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	forkhead box O1	Rattus norvegicus	24-28
12969136-11	2003	Phosphorylation of Akt, FKHR, and FKHRL1 are phosphatidylinositol 3-kinase (PI 3-kinase) dependent since phosphorylation is reduced by the PI 3-kinase inhibitors, wortmannin, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	forkhead box O3	Rattus norvegicus	34-40
12865424-6	2003	LY294002, dominant-negative (DN) phosphatidylinositol 3-kinase (PI3K), or AKT(DN) inhibited NFkappaB activation, p65 transactivation, and cyclooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active (CA) TLR4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nuclear factor kappa B subunit 1	Homo sapiens	92-100
12865424-6	2003	LY294002, dominant-negative (DN) phosphatidylinositol 3-kinase (PI3K), or AKT(DN) inhibited NFkappaB activation, p65 transactivation, and cyclooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active (CA) TLR4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	113-116
12865424-6	2003	LY294002, dominant-negative (DN) phosphatidylinositol 3-kinase (PI3K), or AKT(DN) inhibited NFkappaB activation, p65 transactivation, and cyclooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active (CA) TLR4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	138-154
12865424-6	2003	LY294002, dominant-negative (DN) phosphatidylinositol 3-kinase (PI3K), or AKT(DN) inhibited NFkappaB activation, p65 transactivation, and cyclooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active (CA) TLR4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	156-161
12865424-6	2003	LY294002, dominant-negative (DN) phosphatidylinositol 3-kinase (PI3K), or AKT(DN) inhibited NFkappaB activation, p65 transactivation, and cyclooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active (CA) TLR4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	toll like receptor 4	Homo sapiens	227-231
12951049-9	2003	The activation of AKT, p70(s6k), and ERK1/2 induced by HGF was abolished by pre-treatment with LY294002, a phosphoinositide 3-OH kinase (PI3K) inhibitor, and U0126, a mitogen-activated protein kinase/ERK kinase (MEK) inhibitor, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
14522909-9	2003	Importantly, using pharmacological inhibitors of phosphatidylinositol 3"-kinase (PI3-K) (LY294002 and wortmannin) and extracellular signal-regulated kinase (PD98059), we demonstrate that IGF-I-induced MM cell adhesion to FN is achieved only when PI3-K/AKT is activated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	49-79
12951049-9	2003	The activation of AKT, p70(s6k), and ERK1/2 induced by HGF was abolished by pre-treatment with LY294002, a phosphoinositide 3-OH kinase (PI3K) inhibitor, and U0126, a mitogen-activated protein kinase/ERK kinase (MEK) inhibitor, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	ribosomal protein S6 kinase B1	Rattus norvegicus	27-30
12951049-9	2003	The activation of AKT, p70(s6k), and ERK1/2 induced by HGF was abolished by pre-treatment with LY294002, a phosphoinositide 3-OH kinase (PI3K) inhibitor, and U0126, a mitogen-activated protein kinase/ERK kinase (MEK) inhibitor, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	mitogen activated protein kinase 3	Rattus norvegicus	37-43
12951049-9	2003	The activation of AKT, p70(s6k), and ERK1/2 induced by HGF was abolished by pre-treatment with LY294002, a phosphoinositide 3-OH kinase (PI3K) inhibitor, and U0126, a mitogen-activated protein kinase/ERK kinase (MEK) inhibitor, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	hepatocyte growth factor	Rattus norvegicus	55-58
12951049-9	2003	The activation of AKT, p70(s6k), and ERK1/2 induced by HGF was abolished by pre-treatment with LY294002, a phosphoinositide 3-OH kinase (PI3K) inhibitor, and U0126, a mitogen-activated protein kinase/ERK kinase (MEK) inhibitor, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	107-135
12951049-10	2003	When the cells were pre-treated with LY294002 prior to the HGF stimulation, the proliferative action of HGF was completely abrogated, implying that the PI3K/AKT signaling pathway is responsible for the biological effect of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	hepatocyte growth factor	Rattus norvegicus	59-62
12951049-10	2003	When the cells were pre-treated with LY294002 prior to the HGF stimulation, the proliferative action of HGF was completely abrogated, implying that the PI3K/AKT signaling pathway is responsible for the biological effect of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	hepatocyte growth factor	Rattus norvegicus	104-107
12951049-10	2003	When the cells were pre-treated with LY294002 prior to the HGF stimulation, the proliferative action of HGF was completely abrogated, implying that the PI3K/AKT signaling pathway is responsible for the biological effect of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Rattus norvegicus	157-160
12951049-10	2003	When the cells were pre-treated with LY294002 prior to the HGF stimulation, the proliferative action of HGF was completely abrogated, implying that the PI3K/AKT signaling pathway is responsible for the biological effect of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	hepatocyte growth factor	Rattus norvegicus	104-107
13679862-2	2003	Coexposure of U937 cells for 24 h to marginally toxic concentrations of LY294002 (e.g., 30 microM) and sodium butyrate (SB; 1 mM) resulted in a marked increase in mitochondrial damage (e.g., cytochrome c and Smac/DIABLO release, loss of DeltaPsi(m)), caspase activation, and apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	cytochrome c, somatic	Homo sapiens	191-203
13679862-2	2003	Coexposure of U937 cells for 24 h to marginally toxic concentrations of LY294002 (e.g., 30 microM) and sodium butyrate (SB; 1 mM) resulted in a marked increase in mitochondrial damage (e.g., cytochrome c and Smac/DIABLO release, loss of DeltaPsi(m)), caspase activation, and apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	diablo IAP-binding mitochondrial protein	Homo sapiens	208-212
14522909-9	2003	Importantly, using pharmacological inhibitors of phosphatidylinositol 3"-kinase (PI3-K) (LY294002 and wortmannin) and extracellular signal-regulated kinase (PD98059), we demonstrate that IGF-I-induced MM cell adhesion to FN is achieved only when PI3-K/AKT is activated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	insulin like growth factor 1	Homo sapiens	187-192
14522909-9	2003	Importantly, using pharmacological inhibitors of phosphatidylinositol 3"-kinase (PI3-K) (LY294002 and wortmannin) and extracellular signal-regulated kinase (PD98059), we demonstrate that IGF-I-induced MM cell adhesion to FN is achieved only when PI3-K/AKT is activated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	fibronectin 1	Homo sapiens	221-223
14522909-9	2003	Importantly, using pharmacological inhibitors of phosphatidylinositol 3"-kinase (PI3-K) (LY294002 and wortmannin) and extracellular signal-regulated kinase (PD98059), we demonstrate that IGF-I-induced MM cell adhesion to FN is achieved only when PI3-K/AKT is activated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	AKT serine/threonine kinase 1	Homo sapiens	252-255
12807916-4	2003	LY294002, a dual mTOR and PI3K inhibitor, blocked human inducible nitric oxide synthase (hiNOS) promoter activation and mRNA induction by cytokines and LPS in a PI3K-independent fashion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	17-21
12970746-8	2003	Blocking of the Akt pathway by an Akt-specific inhibitor LY294002 abrogates IL-4-induced PSA expression and AR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	16-19
12970746-8	2003	Blocking of the Akt pathway by an Akt-specific inhibitor LY294002 abrogates IL-4-induced PSA expression and AR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	AKT serine/threonine kinase 1	Homo sapiens	34-37
12970746-8	2003	Blocking of the Akt pathway by an Akt-specific inhibitor LY294002 abrogates IL-4-induced PSA expression and AR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	interleukin 4	Homo sapiens	76-80
12970746-8	2003	Blocking of the Akt pathway by an Akt-specific inhibitor LY294002 abrogates IL-4-induced PSA expression and AR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	kallikrein related peptidase 3	Homo sapiens	89-92
12970746-8	2003	Blocking of the Akt pathway by an Akt-specific inhibitor LY294002 abrogates IL-4-induced PSA expression and AR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	androgen receptor	Homo sapiens	108-110
12807916-5	2003	On gene expression analysis, LY294002 selectively blocked the induction of a subset of 14 LPS/interferon-gamma (IFN-gamma)-induced genes, previously characterized as signal transducer and activator of transcription-1 (STAT1)-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	interferon gamma	Homo sapiens	90-121
12807916-5	2003	On gene expression analysis, LY294002 selectively blocked the induction of a subset of 14 LPS/interferon-gamma (IFN-gamma)-induced genes, previously characterized as signal transducer and activator of transcription-1 (STAT1)-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	signal transducer and activator of transcription 1	Homo sapiens	166-216
12807916-5	2003	On gene expression analysis, LY294002 selectively blocked the induction of a subset of 14 LPS/interferon-gamma (IFN-gamma)-induced genes, previously characterized as signal transducer and activator of transcription-1 (STAT1)-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	signal transducer and activator of transcription 1	Homo sapiens	218-223
12807916-6	2003	LY294002, but not wortmannin, inhibited LPS/IFN-gamma-dependent STAT1 phosphorylation at Ser-727 and STAT1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interferon gamma	Homo sapiens	44-53
12807916-6	2003	LY294002, but not wortmannin, inhibited LPS/IFN-gamma-dependent STAT1 phosphorylation at Ser-727 and STAT1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	signal transducer and activator of transcription 1	Homo sapiens	64-69
12807916-6	2003	LY294002, but not wortmannin, inhibited LPS/IFN-gamma-dependent STAT1 phosphorylation at Ser-727 and STAT1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	signal transducer and activator of transcription 1	Homo sapiens	101-106
12807916-7	2003	Consistent with dual inhibition of mTOR and PI3K by LY294002, dominant-negative mTOR, anti-mTOR small interfering RNA, or rapamycin each inhibited phosphorylation of STAT1 only in the presence of wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	mechanistic target of rapamycin kinase	Homo sapiens	35-39
12807916-7	2003	Consistent with dual inhibition of mTOR and PI3K by LY294002, dominant-negative mTOR, anti-mTOR small interfering RNA, or rapamycin each inhibited phosphorylation of STAT1 only in the presence of wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	signal transducer and activator of transcription 1	Homo sapiens	166-171
12955081-4	2003	In addition to PKC epsilon, PI 3-kinase appeared to participate in the activation of p21(WAF1/Cip1) promoter by apicidin, since inactivation of PI 3-kinase either by transient expression of dominant-negative mutant of PI 3-kinase or its specific inhibitors, LY294002 and wortmannin, attenuated the activation of p21(WAF1/Cip1) promoter and p21(WAF1/Cip1) protein expression by apicidin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	258-266	cyclin dependent kinase inhibitor 1A	Homo sapiens	85-88
12927817-7	2003	The anti-apoptotic effect of EPO was abrogated by co-treatment with LY294002, a specific blocker of phosphatidylinositol 3-kinase (PI3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	erythropoietin	Rattus norvegicus	29-32
12927817-7	2003	The anti-apoptotic effect of EPO was abrogated by co-treatment with LY294002, a specific blocker of phosphatidylinositol 3-kinase (PI3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	100-129
12955081-4	2003	In addition to PKC epsilon, PI 3-kinase appeared to participate in the activation of p21(WAF1/Cip1) promoter by apicidin, since inactivation of PI 3-kinase either by transient expression of dominant-negative mutant of PI 3-kinase or its specific inhibitors, LY294002 and wortmannin, attenuated the activation of p21(WAF1/Cip1) promoter and p21(WAF1/Cip1) protein expression by apicidin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	258-266	cyclin dependent kinase inhibitor 1A	Homo sapiens	85-98
14666721-9	2003	MAP kinases are activated in both cell types in a similar manner, but in HFb cells the inhibition of PI3-kinase by inhibitor LY294002 leads to activation of MAP kinases, while in NIH/3T3 cells this effect does not occur.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	peptidase inhibitor 3	Homo sapiens	101-104
12763754-5	2003	The effects of ANG II on Akt phosphorylation and NO donor-induced CFb apoptosis were abrogated when cells were preincubated with the specific phosphatidylinositol 3-kinase inhibitors wortmannin or LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-206	angiotensinogen	Homo sapiens	15-21
12763754-5	2003	The effects of ANG II on Akt phosphorylation and NO donor-induced CFb apoptosis were abrogated when cells were preincubated with the specific phosphatidylinositol 3-kinase inhibitors wortmannin or LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-206	AKT serine/threonine kinase 1	Homo sapiens	25-28
12900387-4	2003	The PI3K inhibitors wortmannin and LY-294002 inhibited ET-1-induced Ca2+ influx through NSCC-2 but not NSCC-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-44	endothelin 1	Homo sapiens	55-59
12891709-6	2003	Addition of LY294002, an inhibitor of PI3K, reversed the IGF-I-mediated downregulation of p27Kip1 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	insulin-like growth factor 1	Rattus norvegicus	57-62
12939602-6	2003	Inhibition of Akt activation by phosphatidylinositol 3-kinase (PI3-kinase) inhibitor LY294002 significantly decreased the viability of Hep3B and HepG2 cells (P &lt;.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Homo sapiens	14-17
12939297-8	2003	The 8-Br-cAMP and PI 3-kinase inhibitor (LY294002) produced equivalent stimulation and inhibition, respectively, of p27 and Cdk4 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	dynactin subunit 6	Homo sapiens	116-119
12939297-8	2003	The 8-Br-cAMP and PI 3-kinase inhibitor (LY294002) produced equivalent stimulation and inhibition, respectively, of p27 and Cdk4 protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	cyclin dependent kinase 4	Homo sapiens	124-128
12834810-8	2003	The stimulation of PKB induced by cannabinoids was blocked by the two cannabinoid receptor antagonists, SR 141716 and SR 144528, and by the PI3K inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-164	protein tyrosine kinase 2 beta	Homo sapiens	19-22
12940886-9	2003	Vascular endothelial growth factor-induced EPC differentiation was significantly inhibited by pharmacological phosphatidylinositol 3-kinase blockers (either 10 nmol/L wortmannin or 10 micromol/L LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	vascular endothelial growth factor A	Homo sapiens	0-34
12891709-6	2003	Addition of LY294002, an inhibitor of PI3K, reversed the IGF-I-mediated downregulation of p27Kip1 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	90-97
12891709-11	2003	In addition, when the cells were pre-incubated with LY294002 before IGF-I stimulation, the phosphorylation of Akt-Ser473 and FoxO1-Ser256 was inhibited, implying that phosphorylation of Akt and FoxO1 was downstream of IGF-I-induced PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	insulin-like growth factor 1	Rattus norvegicus	68-73
12891709-11	2003	In addition, when the cells were pre-incubated with LY294002 before IGF-I stimulation, the phosphorylation of Akt-Ser473 and FoxO1-Ser256 was inhibited, implying that phosphorylation of Akt and FoxO1 was downstream of IGF-I-induced PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Rattus norvegicus	110-113
12891709-11	2003	In addition, when the cells were pre-incubated with LY294002 before IGF-I stimulation, the phosphorylation of Akt-Ser473 and FoxO1-Ser256 was inhibited, implying that phosphorylation of Akt and FoxO1 was downstream of IGF-I-induced PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	forkhead box O1	Rattus norvegicus	125-130
12891709-11	2003	In addition, when the cells were pre-incubated with LY294002 before IGF-I stimulation, the phosphorylation of Akt-Ser473 and FoxO1-Ser256 was inhibited, implying that phosphorylation of Akt and FoxO1 was downstream of IGF-I-induced PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Rattus norvegicus	186-189
12891709-11	2003	In addition, when the cells were pre-incubated with LY294002 before IGF-I stimulation, the phosphorylation of Akt-Ser473 and FoxO1-Ser256 was inhibited, implying that phosphorylation of Akt and FoxO1 was downstream of IGF-I-induced PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	forkhead box O1	Rattus norvegicus	194-199
12891709-11	2003	In addition, when the cells were pre-incubated with LY294002 before IGF-I stimulation, the phosphorylation of Akt-Ser473 and FoxO1-Ser256 was inhibited, implying that phosphorylation of Akt and FoxO1 was downstream of IGF-I-induced PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	insulin-like growth factor 1	Rattus norvegicus	218-223
12810818-6	2003	In addition, pretreatment of VSMCs with wortmannin or LY294002 inhibited OxLDL-stimulated p42/p44 MAPK phosphorylation and [3H]thymidine incorporation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	cyclin dependent kinase 20	Homo sapiens	90-93
12810818-4	2003	Phosphorylation of Akt stimulated by OxLDL and epidermal growth factor (EGF) was attenuated by inhibitors of PI3-K (wortmannin and LY294002) and intracellular Ca2+ chelator (BAPTA/AM) plus EDTA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	19-22
12810818-6	2003	In addition, pretreatment of VSMCs with wortmannin or LY294002 inhibited OxLDL-stimulated p42/p44 MAPK phosphorylation and [3H]thymidine incorporation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	interferon induced protein 44	Homo sapiens	94-97
12890489-3	2003	We found that the PI3K/Akt inhibitors LY294002 and wortmannin, but not the MEK inhibitor U0126, were capable of inducing apoptosis in growth-arrested Saos-2 cells, as assessed by an increase in the sub-G1 population, pyknotic nuclei, and DNA ladder formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	AKT serine/threonine kinase 1	Homo sapiens	23-26
12970777-8	2003	The PI3K inhibitor LY294002 suppressed Raf-mediated growth, indicating that part of the long-term proliferative effects mediated by Raf are PI3K dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	zinc fingers and homeoboxes 2	Homo sapiens	39-42
12970777-8	2003	The PI3K inhibitor LY294002 suppressed Raf-mediated growth, indicating that part of the long-term proliferative effects mediated by Raf are PI3K dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	zinc fingers and homeoboxes 2	Homo sapiens	132-135
12970779-12	2003	At variance with Ly294002, the Akt inhibitor did not negatively affect phosphorylation of protein kinase C-zeta and it was less effective in downregulating p70S6 kinase (p70S6K) activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	AKT serine/threonine kinase 1	Homo sapiens	31-34
12949840-4	2003	We found that the treatment of cells with rapamycin inhibited EGF-induced cell transformation but only slightly inhibited JB6 cell proliferation at 72 h. Although LY294002, a PI3K inhibitor, attenuated EGF-induced activator protein 1 (AP-1) activation, treatment with rapamycin did not affect AP-1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	epidermal growth factor	Homo sapiens	62-65
12949840-4	2003	We found that the treatment of cells with rapamycin inhibited EGF-induced cell transformation but only slightly inhibited JB6 cell proliferation at 72 h. Although LY294002, a PI3K inhibitor, attenuated EGF-induced activator protein 1 (AP-1) activation, treatment with rapamycin did not affect AP-1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	epidermal growth factor	Homo sapiens	202-205
12805379-6	2003	A phosphoinositide-3 (PI-3) kinase-specific inhibitor (LY294002) decreased the basal level of MMP-2 in wild-type fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	matrix metallopeptidase 2	Homo sapiens	94-99
12920205-7	2003	Wortmannin and LY294002, inhibitors of phosphoinositide 3-kinase (PI3K), partially inhibited ET-1-induced AA release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	endothelin-1	Cricetulus griseus	93-97
12775712-2	2003	Insulin increased VEGF mRNA levels in mouse aortic smooth muscle cells from 10(-9) to 10(-7) m with an initial peak of 3.7-fold increases at 1 h and a second peak of 2.8-fold after 12 h. The first peak of VEGF expression was inhibited by LY294002, an inhibitor of phosphatidylinositol (PI) 3-kinase, and by the overexpression of dominant negative forms of p85 subunit of PI 3-kinase or Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	238-246	vascular endothelial growth factor A	Mus musculus	18-22
12775712-4	2003	In contrast, the chronic effect of insulin on VEGF expression was partially inhibited by both LY294002 or PD98059 as well as by the overexpression of dominant negatives of PI 3-kinase or Ras.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	vascular endothelial growth factor A	Mus musculus	46-50
12890489-4	2003	We detected the cleavage of caspases 9 and 3, and PARP after LY294002 addition, accompanied by a loss of cytochrome c from the mitochondria, and observed Bax translocation to the mitochondria and down-regulation of phospho-Akt, suggesting that blocking of survival signals triggered the apoptotic signal through the mitochondrial apoptotic pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	caspase 9	Homo sapiens	28-44
12890489-4	2003	We detected the cleavage of caspases 9 and 3, and PARP after LY294002 addition, accompanied by a loss of cytochrome c from the mitochondria, and observed Bax translocation to the mitochondria and down-regulation of phospho-Akt, suggesting that blocking of survival signals triggered the apoptotic signal through the mitochondrial apoptotic pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	poly(ADP-ribose) polymerase 1	Homo sapiens	50-54
12890489-4	2003	We detected the cleavage of caspases 9 and 3, and PARP after LY294002 addition, accompanied by a loss of cytochrome c from the mitochondria, and observed Bax translocation to the mitochondria and down-regulation of phospho-Akt, suggesting that blocking of survival signals triggered the apoptotic signal through the mitochondrial apoptotic pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	cytochrome c, somatic	Homo sapiens	105-117
12890489-4	2003	We detected the cleavage of caspases 9 and 3, and PARP after LY294002 addition, accompanied by a loss of cytochrome c from the mitochondria, and observed Bax translocation to the mitochondria and down-regulation of phospho-Akt, suggesting that blocking of survival signals triggered the apoptotic signal through the mitochondrial apoptotic pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Homo sapiens	223-226
12748184-6	2003	Our results also demonstrate that HA/CD44-mediated oncogenic events (e.g. AKT activation, M-CSF production and breast tumor cell-specific phenotypes) can be effectively blocked by a PI 3-kinase inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	CD44 molecule (Indian blood group)	Homo sapiens	37-41
12775708-6	2003	The LTED cells also expressed elevated levels of insulin-like growth factor-1R, and inhibition of phosphatidylinositol 3-kinase activity with LY294002 reduced basal ERalpha transactivation by 70% in the LTED cells compared with the wt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	estrogen receptor 1	Homo sapiens	165-172
12796501-8	2003	Although wortmannin, LY294002, and actinomycin D blocked the increase in SHARP-2 mRNA levels by insulin, rapamycin, staurosporine, PD98059, okadaic acid, and 8-bromocyclic AMP had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	basic helix-loop-helix family, member e40	Rattus norvegicus	73-80
12748184-6	2003	Our results also demonstrate that HA/CD44-mediated oncogenic events (e.g. AKT activation, M-CSF production and breast tumor cell-specific phenotypes) can be effectively blocked by a PI 3-kinase inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	AKT serine/threonine kinase 1	Homo sapiens	74-77
12773534-5	2003	11,12-EET also stimulated the time-dependent phosphorylation of Akt and of the forkhead factors FOXO1 and FOXO3a, effects prevented by the phosphatidylinositol 3-kinase inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-188	AKT serine/threonine kinase 1	Homo sapiens	64-67
12773534-5	2003	11,12-EET also stimulated the time-dependent phosphorylation of Akt and of the forkhead factors FOXO1 and FOXO3a, effects prevented by the phosphatidylinositol 3-kinase inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-188	forkhead box O1	Homo sapiens	96-101
12773534-5	2003	11,12-EET also stimulated the time-dependent phosphorylation of Akt and of the forkhead factors FOXO1 and FOXO3a, effects prevented by the phosphatidylinositol 3-kinase inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-188	forkhead box O3	Homo sapiens	106-112
12748184-6	2003	Our results also demonstrate that HA/CD44-mediated oncogenic events (e.g. AKT activation, M-CSF production and breast tumor cell-specific phenotypes) can be effectively blocked by a PI 3-kinase inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	colony stimulating factor 1	Homo sapiens	90-95
12689859-10	2003	MCSF-induced endothelial monocyte chemoattractant protein-1 upregulation was inhibited by herbimycin A, a tyrosine kinase inhibitor, and by LY-294002, a phosphatidylinositol 3"-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-149	C-C motif chemokine ligand 2	Canis lupus familiaris	25-59
12835226-8	2003	Forkhead transcription factor inactivation and p27Kip1 downregulation were prevented by the PI3-K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	cyclin dependent kinase inhibitor 1B	Homo sapiens	47-54
14585539-7	2003	Furthermore, treatment of cells with specific PK inhibitors known to be involved in serine phosphorylation of Bad (LY294002 for PI3K and H-89 for PKA) mimiced or enhanced BCR-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	BCR activator of RhoGEF and GTPase	Mus musculus	171-174
12702491-10	2003	Treatment with LY-294002, a PI3-kinase blocker, partly reverted the effect of EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	epidermal growth factor	Mus musculus	78-81
12686512-7	2003	Pharmacological inhibition of the kinase activity of PI3K with LY-294002 decreases the phosphorylation of JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-72	mitogen-activated protein kinase 8	Mus musculus	106-109
12879014-7	2003	In contrast, treatment of cells with LY294002, to inhibit phosphoinositide 3-kinase (PI3K), caused downregulation of Bcl-2 and Mcl-1 and allowed deltaMEKK1:ER* to elicit a robust apoptotic response characterized by activation of Bax and caspases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	BCL2 apoptosis regulator	Homo sapiens	117-122
12781867-6	2003	However, a cell-permeable, specific inhibitor of Mnk1, CGP57380 and the phosphatidylinositol-3-kinase (PI3-K) inhibitor, LY294002, prevented eIF4E phosphorylation in 293 cells irrespective of SAPK2a expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	72-101
12882906-8	2003	Stimulation of glucose transport and GLUT4 translocation by bpV(phen) was completely blocked by the phosphatidylinositol 3-kinase (PI 3-K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	solute carrier family 2 member 4	Homo sapiens	37-42
12882906-8	2003	Stimulation of glucose transport and GLUT4 translocation by bpV(phen) was completely blocked by the phosphatidylinositol 3-kinase (PI 3-K) inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	100-129
12884287-3	2003	4-1BB increases cyclin D2 transcription via mitogen-activated/extracellular signal-regulated kinase-1/2 and LY294002-sensitive phosphatidylinositol 3-kinase (PI3K) signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	TNF receptor superfamily member 9	Homo sapiens	0-5
12884287-3	2003	4-1BB increases cyclin D2 transcription via mitogen-activated/extracellular signal-regulated kinase-1/2 and LY294002-sensitive phosphatidylinositol 3-kinase (PI3K) signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	cyclin D2	Homo sapiens	16-25
12884287-3	2003	4-1BB increases cyclin D2 transcription via mitogen-activated/extracellular signal-regulated kinase-1/2 and LY294002-sensitive phosphatidylinositol 3-kinase (PI3K) signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	127-156
12869650-4	2003	Unlike Gi-coupled chemoattractant receptors, D2R activated NF-kappaB without an increase in phospholipase C-beta activity, and the response was only slightly affected by the phosphoinositide 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-258	dopamine receptor D2	Homo sapiens	45-48
12869650-4	2003	Unlike Gi-coupled chemoattractant receptors, D2R activated NF-kappaB without an increase in phospholipase C-beta activity, and the response was only slightly affected by the phosphoinositide 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	260-268	dopamine receptor D2	Homo sapiens	45-48
12781867-6	2003	However, a cell-permeable, specific inhibitor of Mnk1, CGP57380 and the phosphatidylinositol-3-kinase (PI3-K) inhibitor, LY294002, prevented eIF4E phosphorylation in 293 cells irrespective of SAPK2a expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	eukaryotic translation initiation factor 4E	Homo sapiens	141-146
12781867-6	2003	However, a cell-permeable, specific inhibitor of Mnk1, CGP57380 and the phosphatidylinositol-3-kinase (PI3-K) inhibitor, LY294002, prevented eIF4E phosphorylation in 293 cells irrespective of SAPK2a expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	mitogen-activated protein kinase 14	Homo sapiens	192-198
12771144-9	2003	However, both pharmacological (wortmannin and LY294002) and genetic (Deltap85) inhibitors of PI 3"-kinase inhibited OPN-induced Akt phosphorylation, IKK activity, and NFkappaB activation through phosphorylation and degradation of IkappaBalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	secreted phosphoprotein 1	Homo sapiens	116-119
12771144-9	2003	However, both pharmacological (wortmannin and LY294002) and genetic (Deltap85) inhibitors of PI 3"-kinase inhibited OPN-induced Akt phosphorylation, IKK activity, and NFkappaB activation through phosphorylation and degradation of IkappaBalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Homo sapiens	128-131
12771144-9	2003	However, both pharmacological (wortmannin and LY294002) and genetic (Deltap85) inhibitors of PI 3"-kinase inhibited OPN-induced Akt phosphorylation, IKK activity, and NFkappaB activation through phosphorylation and degradation of IkappaBalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	nuclear factor kappa B subunit 1	Homo sapiens	167-175
12879014-7	2003	In contrast, treatment of cells with LY294002, to inhibit phosphoinositide 3-kinase (PI3K), caused downregulation of Bcl-2 and Mcl-1 and allowed deltaMEKK1:ER* to elicit a robust apoptotic response characterized by activation of Bax and caspases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	127-132
12879014-7	2003	In contrast, treatment of cells with LY294002, to inhibit phosphoinositide 3-kinase (PI3K), caused downregulation of Bcl-2 and Mcl-1 and allowed deltaMEKK1:ER* to elicit a robust apoptotic response characterized by activation of Bax and caspases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	BCL2 associated X, apoptosis regulator	Homo sapiens	229-232
14508113-5	2003	The data revealed decreased Rac1 activity within 4 h, and a decrease in the Rac1 effector, PAK1, within 12 h. In addition, an increase in PI3K and ERK1/2 activities within 1 h of recombinant maspin (rMaspin) treatment was observed, which returned to baseline level after 12 h. ERK activity was shown to be downstream of PI3K, as pretreatment with the PI3K inhibitor, LY294002, inhibited the stimulation of ERK activity by rMaspin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	367-375	serpin family B member 5	Homo sapiens	191-197
12874004-3	2003	Ten to 20 micro M LY294002 augmented both apoptosis and caspase 3-like activity caused by antimicrotubule agents to a larger extent than induced by 1,3-bis(2-chloroethyl)-1-nitrosourea, etoposide, and cisplatin in all four malignant glioma cell lines examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	caspase 3	Homo sapiens	56-65
12874004-6	2003	Our study indicates that the synergistic augmentation of the cytotoxicity by LY294002 occurs specifically with antimicrotubule agents, at least partially through an increase in caspase 3-dependent apoptosis, and we suggest that inhibitors of the PI3K/Akt pathway in combination with antimicrotubule agents may induce cell death effectively and be a potent modality to treat patients with malignant gliomas.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	caspase 3	Homo sapiens	177-186
12874004-6	2003	Our study indicates that the synergistic augmentation of the cytotoxicity by LY294002 occurs specifically with antimicrotubule agents, at least partially through an increase in caspase 3-dependent apoptosis, and we suggest that inhibitors of the PI3K/Akt pathway in combination with antimicrotubule agents may induce cell death effectively and be a potent modality to treat patients with malignant gliomas.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	251-254
12847277-9	2003	The antiapoptotic actions of IFN-beta were targeted at an early stage of neutrophil apoptosis, occurring upstream of mitochondrial permeability transition, and were phosphatidylinositol 3-kinase (PI3K) dependent, as they were blocked by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	256-264	interferon beta 1	Homo sapiens	29-37
12738789-3	2003	Whereas both cell lines are equally susceptible to LY294002-mediated Akt dephosphorylation, only LNCaP cells default to apoptosis, as evidenced by DNA fragmentation and cytochrome c release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	69-72
12738789-7	2003	Second, ectopic expression of Bcl-xL protects LNCaP cells against LY294002-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	BCL2 like 1	Homo sapiens	30-36
12738789-8	2003	Third, antisense down-regulation of Bcl-xL sensitizes PC-3 cells to the apoptotic effect of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	BCL2 like 1	Homo sapiens	36-42
12738789-9	2003	The physiological relevance of this Bcl-xL-mediated survival mechanism is further underscored by the protective effect of serum on LY294002-induced cell death in LNCaP cells, which is correlated with a multifold increase in Bcl-xL expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	BCL2 like 1	Homo sapiens	36-42
12738789-9	2003	The physiological relevance of this Bcl-xL-mediated survival mechanism is further underscored by the protective effect of serum on LY294002-induced cell death in LNCaP cells, which is correlated with a multifold increase in Bcl-xL expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	BCL2 like 1	Homo sapiens	224-230
12850478-6	2003	In addition, caspase-3 was activated by treatment of cells with STI571 and LY294002 but not with PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	caspase 3	Homo sapiens	13-22
12742227-7	2003	The expression of constitutively activated Akt partially reversed the inhibitory effects of LY294002 on mitotic entry, which demonstrated that Akt was one PI3K target that was required during G2/M transitions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	43-46
12742227-7	2003	The expression of constitutively activated Akt partially reversed the inhibitory effects of LY294002 on mitotic entry, which demonstrated that Akt was one PI3K target that was required during G2/M transitions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	143-146
12767057-5	2003	Constitutive NF-kappaB/Rel activity and the transactivation potential of RelA(p65) can be inhibited by dominant negative mutant Ras, the PI3 kinase inhibitor LY294002, or dominant negative mutant Akt kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	nuclear factor kappa B subunit 1	Homo sapiens	13-22
12767057-5	2003	Constitutive NF-kappaB/Rel activity and the transactivation potential of RelA(p65) can be inhibited by dominant negative mutant Ras, the PI3 kinase inhibitor LY294002, or dominant negative mutant Akt kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	RELA proto-oncogene, NF-kB subunit	Homo sapiens	73-77
12767057-5	2003	Constitutive NF-kappaB/Rel activity and the transactivation potential of RelA(p65) can be inhibited by dominant negative mutant Ras, the PI3 kinase inhibitor LY294002, or dominant negative mutant Akt kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	RELA proto-oncogene, NF-kB subunit	Homo sapiens	78-81
12767057-6	2003	Transfection of a dominant negative mutant epidermal growth factor receptor (EGF-R), EGF-R kinase inhibitor Tyrphostin and LY 294002 blocked IKK activity and NF-kappaB-dependent transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-132	nuclear factor kappa B subunit 1	Homo sapiens	158-167
12874030-9	2003	In vitro, PIK3CA expression positively correlated with the expression of VEGF in ovarian cancer cells, whereas the phosphatidylinositol 3"-kinase inhibitor Ly294002 reduced both the constitutive and inducible expression of hypoxia-inducible factor-1alpha at the mRNA and protein levels and abrogated VEGF up-regulation by glucose starvation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	vascular endothelial growth factor A	Homo sapiens	73-77
12874030-9	2003	In vitro, PIK3CA expression positively correlated with the expression of VEGF in ovarian cancer cells, whereas the phosphatidylinositol 3"-kinase inhibitor Ly294002 reduced both the constitutive and inducible expression of hypoxia-inducible factor-1alpha at the mRNA and protein levels and abrogated VEGF up-regulation by glucose starvation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	hypoxia inducible factor 1 subunit alpha	Homo sapiens	223-254
12874030-9	2003	In vitro, PIK3CA expression positively correlated with the expression of VEGF in ovarian cancer cells, whereas the phosphatidylinositol 3"-kinase inhibitor Ly294002 reduced both the constitutive and inducible expression of hypoxia-inducible factor-1alpha at the mRNA and protein levels and abrogated VEGF up-regulation by glucose starvation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	vascular endothelial growth factor A	Homo sapiens	300-304
12714587-8	2003	Blocking this basal Akt phosphorylation with LY294002, an inhibitor of phosphatidylinositol 3-kinase, did not affect their viability but blocking of EGF-induced phosphorylation of Akt sensitized the otherwise resistant A431-RelA cells to EGF-mediated growth inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	20-23
12839945-2	2003	Herein, we demonstrated the first evidence that the systemic administration of a phosphatidylinositol 3"-kinase (PI3K) inhibitor (LY294002) has antitumor and antiangiogenic activity in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	130-138	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	81-111
12839945-4	2003	PTEN and LY294002 induced p53 activity in human brain endothelial cells, suggesting that PTEN and PI3K pathways can suppress the progression of cancer through direct actions on tumor and endothelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	tumor protein p53	Homo sapiens	26-29
12839945-4	2003	PTEN and LY294002 induced p53 activity in human brain endothelial cells, suggesting that PTEN and PI3K pathways can suppress the progression of cancer through direct actions on tumor and endothelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	phosphatase and tensin homolog	Homo sapiens	89-93
12943808-13	2003	Activation of p38(MAPK) was significantly inhibited by SB203580, pertussis toxin, Wortmannin, and LY294002, but not by PD98059 or AG1478; MAPKAP kinase-2 activation was inhibited by SB203580.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	mitogen-activated protein kinase 1	Homo sapiens	14-17
12855613-11	2003	HIF-1 activation by DHT was blocked by LY294002, a potent inhibitor of the phosphatidylinositol 3"-kinase signaling pathway, whereas HIF-1 activation by EGF, as ligand, was not inhibited by flutamide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
12788194-8	2003	In vivo sensitization was measured using clonogenic assays or regrowth assays.A dose of 100 mg/kg of LY294002, but not 50 mg/kg, consistently eliminated the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Homo sapiens	176-179
12827036-5	2003	Western blot analysis showed that the extent of phosphorylation of Akt, an active form of Akt, was increased by cerivastatin while it was reduced by LY294002, suggesting an involvement of PI3 kinase/Akt-dependent activation of endothelial NOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	AKT serine/threonine kinase 1	Rattus norvegicus	67-70
12815714-7	2003	The PI3K specific inhibitor LY294002 (10-50 microM) blocked GDNF-mediated protection against nuclear condensation, as did the MAPK kinase (MEK) inhibitor U0126 (5- 20 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	glial cell line derived neurotrophic factor	Mus musculus	60-64
12829832-6	2003	Furthermore, the PI3K-specific inhibitor LY294002 could inhibit Akt activation and cell transformation in all cases, indicating that Akt activation and transformation is PI3K dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	64-67
12829832-6	2003	Furthermore, the PI3K-specific inhibitor LY294002 could inhibit Akt activation and cell transformation in all cases, indicating that Akt activation and transformation is PI3K dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	133-136
12943808-14	2003	Akt was activated by S-1-P at 3 to 5 min; this response was inhibited by Wortmannin and LY294002, but not by SB203580 or pertussis toxin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Homo sapiens	0-3
12808085-9	2003	In addition, inhibition of endogenous Akt activity by the PI3K/Akt inhibitor LY294002 abolishes transcriptional cooperativity between the bHLH proteins and p300.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	38-41
12808085-9	2003	In addition, inhibition of endogenous Akt activity by the PI3K/Akt inhibitor LY294002 abolishes transcriptional cooperativity between the bHLH proteins and p300.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	63-66
12808085-9	2003	In addition, inhibition of endogenous Akt activity by the PI3K/Akt inhibitor LY294002 abolishes transcriptional cooperativity between the bHLH proteins and p300.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	E1A binding protein p300	Homo sapiens	156-160
12746839-0	2003	ErbB1 and prostate cancer: ErbB1 activity is essential for androgen-induced proliferation and protection from the apoptotic effects of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	epidermal growth factor receptor	Homo sapiens	0-5
12832475-4	2003	Photoaffinity labeling of Rab4 with [gamma-(32)P]GTP-azidoanilide showed that insulin stimulated Rab4 GTP loading and that this insulin effect was inhibited by pretreatment with the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor LY294002 or expression of dominant-negative protein kinase C-lambda (PKC-lambda).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	235-243	RAB4A, member RAS oncogene family	Mus musculus	26-30
12832475-4	2003	Photoaffinity labeling of Rab4 with [gamma-(32)P]GTP-azidoanilide showed that insulin stimulated Rab4 GTP loading and that this insulin effect was inhibited by pretreatment with the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor LY294002 or expression of dominant-negative protein kinase C-lambda (PKC-lambda).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	235-243	RAB4A, member RAS oncogene family	Mus musculus	97-101
12832475-8	2003	A microtubule capture assay demonstrated that insulin stimulation increased the activity for the binding of KIF3 to microtubules and that this activation was inhibited by pretreatment with the PI3-kinase inhibitor LY294002 or expression of dominant-negative PKC-lambda.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	kinesin family member 3A	Mus musculus	108-112
12746839-0	2003	ErbB1 and prostate cancer: ErbB1 activity is essential for androgen-induced proliferation and protection from the apoptotic effects of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	epidermal growth factor receptor	Homo sapiens	27-32
12714585-8	2003	Furthermore, LY294002 induced apoptosis of MKK4-null but not wild-type mouse embryo fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	mitogen-activated protein kinase kinase 4	Mus musculus	43-47
12676940-2	2003	Pretreatment of neutrophils with LY294002 or PP1 (inhibiting phosphatidylinositol 3-kinase (PI 3-kinase) and Src kinases, respectively) partly reversed the beta2 integrin-induced down-regulation of Rac activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	156-161
12676940-2	2003	Pretreatment of neutrophils with LY294002 or PP1 (inhibiting phosphatidylinositol 3-kinase (PI 3-kinase) and Src kinases, respectively) partly reversed the beta2 integrin-induced down-regulation of Rac activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Homo sapiens	198-201
12686553-4	2003	Inhibition of phosphatidylinositol 3"-kinase using LY294002 blocked TLR4-induced STAT1 tyrosine phosphorylation, but this inhibitor had no effect on STAT1 serine phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	toll-like receptor 4	Mus musculus	68-72
12821943-4	2003	Treatment with either PD98059 (PD) or LY294002 (LY), the pharmacological inhibitors of MEK-ERK and PI3K, respectively, markedly increased GAS-Luc activity in LU1205, but not in FEMX cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	mitogen-activated protein kinase kinase 7	Homo sapiens	87-90
12821943-4	2003	Treatment with either PD98059 (PD) or LY294002 (LY), the pharmacological inhibitors of MEK-ERK and PI3K, respectively, markedly increased GAS-Luc activity in LU1205, but not in FEMX cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	mitogen-activated protein kinase 1	Homo sapiens	91-94
12821943-4	2003	Treatment with either PD98059 (PD) or LY294002 (LY), the pharmacological inhibitors of MEK-ERK and PI3K, respectively, markedly increased GAS-Luc activity in LU1205, but not in FEMX cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-40	mitogen-activated protein kinase kinase 7	Homo sapiens	87-90
12821943-4	2003	Treatment with either PD98059 (PD) or LY294002 (LY), the pharmacological inhibitors of MEK-ERK and PI3K, respectively, markedly increased GAS-Luc activity in LU1205, but not in FEMX cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-40	mitogen-activated protein kinase 1	Homo sapiens	91-94
12686553-4	2003	Inhibition of phosphatidylinositol 3"-kinase using LY294002 blocked TLR4-induced STAT1 tyrosine phosphorylation, but this inhibitor had no effect on STAT1 serine phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	signal transducer and activator of transcription 1	Mus musculus	81-86
12782568-4	2003	METHODS AND RESULTS: In a multichannel scratch assay with human endothelial cells (ECs), HGF/SF induced a strong and prolonged activation of MAPK and cell proliferation that was inhibited by PD98059 and LY294002/wortmannin, selective inhibitors of MAPK and PI3K signaling modules, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	hepatocyte growth factor	Homo sapiens	89-95
12668683-7	2003	The TSH-induced S6K1 phosphorylation was inhibited by a dominant negative p85alpha regulatory subunit or by the PI3K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	ribosomal protein S6 kinase B1	Homo sapiens	16-20
12663669-6	2003	In contrast, overexpression of Bcl-2 protects EC treated with cytokine plus LY294002 but not EC treated with cytokine plus cycloheximide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	BCL2 apoptosis regulator	Homo sapiens	31-36
12663669-7	2003	The cathepsin B inhibitor CA-074-Me prevents loss of DeltaPsi, caspase activation, and cell death for EC treated with cytokine plus LY294002 but has no effect on EC treated with cytokine plus cycloheximide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	cathepsin B	Homo sapiens	4-15
12663669-8	2003	Cathepsin B translocates from lysosomes to cytosol following treatment with LY294002 prior to the activation of caspases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	cathepsin B	Homo sapiens	0-11
12782312-6	2003	Ly294002, a pharmacological inhibitor of PI 3 kinase, blocked BMP-2-induced PI 3 kinase activity completely.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	bone morphogenetic protein 2	Rattus norvegicus	62-67
12842760-5	2003	However, pretreatment with LY 294002 inhibited LPS induced TNFalpha production (82+/-13% inhibition, n=3, p&lt;0.05), but did not inhibit GBS or SA induced TNFalpha production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-36	toll-like receptor 4	Mus musculus	47-50
12842760-5	2003	However, pretreatment with LY 294002 inhibited LPS induced TNFalpha production (82+/-13% inhibition, n=3, p&lt;0.05), but did not inhibit GBS or SA induced TNFalpha production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-36	tumor necrosis factor	Homo sapiens	59-67
12842760-6	2003	In THP-1 cells, pretreatment with PTx, PP2 and LY 294002 inhibited TNFalpha production induced by LPS (84+/-3%, 59+/-12% and 84+/-4% inhibition, n=3, p&lt;0.05, respectively) and SA (56+/-7%, 87+/-1% and 35+/-6% inhibition, n=3, p&lt;0.05, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-56	tumor necrosis factor	Homo sapiens	67-75
12842760-6	2003	In THP-1 cells, pretreatment with PTx, PP2 and LY 294002 inhibited TNFalpha production induced by LPS (84+/-3%, 59+/-12% and 84+/-4% inhibition, n=3, p&lt;0.05, respectively) and SA (56+/-7%, 87+/-1% and 35+/-6% inhibition, n=3, p&lt;0.05, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-56	toll-like receptor 4	Mus musculus	98-101
12773486-7	2003	Both SNAP and 8-Br-cGMP induced endogenous Akt activation and Bad phosphorylation, resulting in the inhibition of Bad translocation to mitochondria; these effects were inhibited by KT5823 and the phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 and Wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	244-252	AKT serine/threonine kinase 1	Rattus norvegicus	43-46
12759249-5	2003	Capillary-like tube formation induced by Ang1* in fibrin matrix at 24 hours (differentiation index, DI: 13.74 +/- 0.76 versus control 1.71 +/- 0.31) was abolished in the presence of the selective PI3-kinase inhibitor, LY294002 (50 micro mol/L) (DI: 0.31 +/- 0.31, P &lt; 0.01) or the NOS inhibitor, L-NAME (3 mmol/L) (DI: 4.10 +/- 0.59, P &lt; 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	angiopoietin 1	Homo sapiens	41-45
12681450-6	2003	This report shows that the PI3K inhibitors LY294002 and wortmannin block activation of MEK and ERK by IL-2 in primary human T cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	mitogen-activated protein kinase kinase 7	Homo sapiens	87-90
12681450-6	2003	This report shows that the PI3K inhibitors LY294002 and wortmannin block activation of MEK and ERK by IL-2 in primary human T cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	mitogen-activated protein kinase 1	Homo sapiens	95-98
12681450-6	2003	This report shows that the PI3K inhibitors LY294002 and wortmannin block activation of MEK and ERK by IL-2 in primary human T cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	interleukin 2	Homo sapiens	102-106
12877804-4	2003	Meanwhile, LY294002 contributed to apoptosis, caused 2BS cell growth arrest, and activated senescence association beta-galactosidase (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	galactosidase beta 1	Homo sapiens	114-132
12877804-5	2003	In addition, LY294002 could induce time-course expressions of p16(INK4) and p21(Cip1) in 2BS cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cyclin dependent kinase inhibitor 2A	Homo sapiens	62-65
12877804-5	2003	In addition, LY294002 could induce time-course expressions of p16(INK4) and p21(Cip1) in 2BS cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cyclin dependent kinase inhibitor 2A	Homo sapiens	66-70
12877804-5	2003	In addition, LY294002 could induce time-course expressions of p16(INK4) and p21(Cip1) in 2BS cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	H3 histone pseudogene 16	Homo sapiens	76-79
12877804-5	2003	In addition, LY294002 could induce time-course expressions of p16(INK4) and p21(Cip1) in 2BS cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	80-84
12794834-8	2003	EGF-mediated induction of TGFbetaRII expression was inhibited by treatment of fibroblasts with the selective phosphoinositide 3-kinase (PI 3-kinase) inhibitors wortmannin or LY294002, and Akt inhibitor also blocked EGF-induced expression of TGFbetaRII.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	epidermal growth factor	Homo sapiens	0-3
12794834-8	2003	EGF-mediated induction of TGFbetaRII expression was inhibited by treatment of fibroblasts with the selective phosphoinositide 3-kinase (PI 3-kinase) inhibitors wortmannin or LY294002, and Akt inhibitor also blocked EGF-induced expression of TGFbetaRII.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	transforming growth factor beta receptor 2	Homo sapiens	26-36
12794834-9	2003	In addition, EGF induced TGFbetaRII promoter activity, and this induction was significantly blocked by wortmannin, LY294002, or Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	epidermal growth factor	Homo sapiens	13-16
12794834-9	2003	In addition, EGF induced TGFbetaRII promoter activity, and this induction was significantly blocked by wortmannin, LY294002, or Akt inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	transforming growth factor beta receptor 2	Homo sapiens	25-35
12681445-4	2003	Since a protein kinase C (PKC) inhibitor, chelerythrine, or a PI3-kinase inhibitor, LY294002, suppressed cell proliferation effectively, both PKC and PI-3-kinase pathways are presumed to be involved in the cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	protein kinase C alpha	Homo sapiens	142-145
12786942-7	2003	Treatment of cells with either LY294002, a PI3K inhibitor, or expression of a dominant negative form of Akt drastically suppressed the IL-1beta-dependent secretion of MMP-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	interleukin 1 beta	Mus musculus	135-143
12786942-7	2003	Treatment of cells with either LY294002, a PI3K inhibitor, or expression of a dominant negative form of Akt drastically suppressed the IL-1beta-dependent secretion of MMP-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	matrix metallopeptidase 9	Mus musculus	167-172
12773486-7	2003	Both SNAP and 8-Br-cGMP induced endogenous Akt activation and Bad phosphorylation, resulting in the inhibition of Bad translocation to mitochondria; these effects were inhibited by KT5823 and the phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 and Wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	244-252	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	196-225
12595573-4	2003	Selective inhibitors for phosphoinositide 3-kinase (PI3K), such as wortmannin and LY294002, showed a dose-dependent inhibition of relaxin-mediated increases in cAMP, specific for the second peak of the relaxin time course.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	25-50
12869527-9	2003	The addition of LY294002, a specific inhibitor of PI3-K, enhanced the ASK1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	70-74
12637493-5	2003	The anti-apoptotic effect as well as in vitro vessel-like formation and Akt phosphorylation were inhibited by treatment of HMEC with two unrelated pharmacological inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	230-238	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	177-206
12714564-7	2003	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (10 micromol/L) inhibited HIMF-activated Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	resistin like alpha	Rattus norvegicus	86-90
12714564-7	2003	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (10 micromol/L) inhibited HIMF-activated Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Rattus norvegicus	101-104
12730091-6	2003	VLDL-induced NFAT translocation and proliferation were blocked by cyclosporin A and LY294002 involving calcineurin and phosphatidylinositol 3-kinase (PI3K) pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	nuclear factor of activated T-cells 5	Rattus norvegicus	13-17
12730091-6	2003	VLDL-induced NFAT translocation and proliferation were blocked by cyclosporin A and LY294002 involving calcineurin and phosphatidylinositol 3-kinase (PI3K) pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	119-148
12761494-10	2003	Neither did the basal Akt activity correlate with the sensitivity towards gemcitabine treatment, nor did the inhibition of PI3K/Akt by LY294002 alter gemcitabine-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Homo sapiens	128-131
12761496-5	2003	Furthermore, the cytoplasmic p21 accumulation observed in PTX-treated cells was inhibited by LY 294002, a specific PI-3 kinase inhibitor or by the expression of a dominant-negative AKT mutant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-102	H3 histone pseudogene 16	Homo sapiens	29-32
12729801-8	2003	In contrast, similar concentrations of either wortmannin or LY294002 were required to inhibit both IGF-I-induced PI3K activation and migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	insulin like growth factor 1	Homo sapiens	99-104
12522014-6	2003	HMVECs pretreated with the Src inhibitor (PP2) and the PI3K inhibitor (LY294002) or transfected with Src antisense oligonucleotides or Akt dominant-negative mutants significantly inhibited sE-selectin-mediated HMVEC tube formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-30
12522014-6	2003	HMVECs pretreated with the Src inhibitor (PP2) and the PI3K inhibitor (LY294002) or transfected with Src antisense oligonucleotides or Akt dominant-negative mutants significantly inhibited sE-selectin-mediated HMVEC tube formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	101-104
12522014-6	2003	HMVECs pretreated with the Src inhibitor (PP2) and the PI3K inhibitor (LY294002) or transfected with Src antisense oligonucleotides or Akt dominant-negative mutants significantly inhibited sE-selectin-mediated HMVEC tube formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Homo sapiens	135-138
12729802-9	2003	Both basal and ATF-mediated migratory responses were suppressed in the presence of selective pharmacological inhibitors LY294002, U73122, and U0126, implicating the respective roles of phosphatidinylinositol 3-kinase (PI 3-K), phospholipase C (PLC), and MEK1/2 in basal and ATF-stimulated migratory capacity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	185-216
12594228-4	2003	Desensitization was correlated to a reduction in insulin receptor substrate (IRS)-1 and IRS-2 protein levels, which was reversed by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	insulin receptor substrate 1	Cricetulus griseus	49-83
12621049-4	2003	This suppressive effect could be blocked by either dominant-negative Akt or dominant-negative PI3K or LY294002, suggesting that the APPL-mediated suppression of AR transactivation is dependent on the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Homo sapiens	132-136
12621049-4	2003	This suppressive effect could be blocked by either dominant-negative Akt or dominant-negative PI3K or LY294002, suggesting that the APPL-mediated suppression of AR transactivation is dependent on the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	androgen receptor	Homo sapiens	161-163
12621049-7	2003	The abrogation of IGF-1-mediated Akt activation by the dominant-negative PI3K or LY294002 or antisense APPL suggests that APPL may function as an important adapter protein in controlling the IGF-1 --&gt; Akt signal pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	insulin like growth factor 1	Homo sapiens	18-23
12621049-7	2003	The abrogation of IGF-1-mediated Akt activation by the dominant-negative PI3K or LY294002 or antisense APPL suggests that APPL may function as an important adapter protein in controlling the IGF-1 --&gt; Akt signal pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	AKT serine/threonine kinase 1	Homo sapiens	33-36
12621049-7	2003	The abrogation of IGF-1-mediated Akt activation by the dominant-negative PI3K or LY294002 or antisense APPL suggests that APPL may function as an important adapter protein in controlling the IGF-1 --&gt; Akt signal pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Homo sapiens	122-126
12621049-7	2003	The abrogation of IGF-1-mediated Akt activation by the dominant-negative PI3K or LY294002 or antisense APPL suggests that APPL may function as an important adapter protein in controlling the IGF-1 --&gt; Akt signal pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	insulin like growth factor 1	Homo sapiens	191-196
12594228-8	2003	Suppression of IRS-1/2 down-regulation by LY294002 rescued the responsiveness of PKB and MAPK toward acute insulin stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	insulin receptor substrate 1	Cricetulus griseus	15-22
12594228-4	2003	Desensitization was correlated to a reduction in insulin receptor substrate (IRS)-1 and IRS-2 protein levels, which was reversed by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	insulin receptor substrate 2	Cricetulus griseus	88-93
12594228-8	2003	Suppression of IRS-1/2 down-regulation by LY294002 rescued the responsiveness of PKB and MAPK toward acute insulin stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	insulin	Cricetulus griseus	107-114
12594228-5	2003	Co-treatment of cells with insulin and LY294002, while reducing total IRS-1 phosphorylation, increased its phosphotyrosine content, enhancing IRS-1/PI3K association.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	insulin receptor substrate 1	Cricetulus griseus	70-75
12594228-5	2003	Co-treatment of cells with insulin and LY294002, while reducing total IRS-1 phosphorylation, increased its phosphotyrosine content, enhancing IRS-1/PI3K association.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	insulin receptor substrate 1	Cricetulus griseus	142-147
12684213-6	2003	The LPA-elicited antiapoptotic activity and inhibition of caspase-9 activity were abrogated by pertussis toxin, PD 98059, wortmannin, and LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-147	caspase 9	Rattus norvegicus	58-67
12668516-4	2003	Moreover, experiments performed with a pharmacological inhibitor of the phosphatidylinositol 3-kinase/Akt pathway (LY294002) or a dominant-negative Akt (K179M) demonstrated that TRAIL significantly protected HUVECs from apoptosis induced by trophic withdrawal via Akt and that inhibition of Akt sensitized HUVECs to TRAIL-induced caspase-dependent apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	AKT serine/threonine kinase 1	Homo sapiens	102-105
12668516-4	2003	Moreover, experiments performed with a pharmacological inhibitor of the phosphatidylinositol 3-kinase/Akt pathway (LY294002) or a dominant-negative Akt (K179M) demonstrated that TRAIL significantly protected HUVECs from apoptosis induced by trophic withdrawal via Akt and that inhibition of Akt sensitized HUVECs to TRAIL-induced caspase-dependent apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	TNF superfamily member 10	Homo sapiens	178-183
12778079-8	2003	For the analysis of phosphatidylinositol-3 kinase (PI3-K) dependence of protein kinases and cell cycle transition, the PI3-K inhibitors LY294002 and wortmannin were used showing decreased kinase activities, antiproliferative and radiation-dependent G2 accumulation-abrogating effects accompanied by downregulation of cyclin D1 and phospho-pRb in cells attached to polystyrene.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	20-49
12711332-5	2003	PD098059 and U0126 (two MEK inhibitors), and LY294002 (a PI3K inhibitor) inhibited GM-CSF/IL-10-induced CCR1 gene and protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	colony stimulating factor 2	Homo sapiens	83-89
12711332-5	2003	PD098059 and U0126 (two MEK inhibitors), and LY294002 (a PI3K inhibitor) inhibited GM-CSF/IL-10-induced CCR1 gene and protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	interleukin 10	Homo sapiens	90-95
12711332-5	2003	PD098059 and U0126 (two MEK inhibitors), and LY294002 (a PI3K inhibitor) inhibited GM-CSF/IL-10-induced CCR1 gene and protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	C-C motif chemokine receptor 1	Homo sapiens	104-108
12711332-6	2003	PD098059, U0126, and LY294002 also attenuated chemotaxis of GM-CSF/IL-10-primed U937 cells in response to MIP-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	colony stimulating factor 2	Homo sapiens	60-66
12711332-6	2003	PD098059, U0126, and LY294002 also attenuated chemotaxis of GM-CSF/IL-10-primed U937 cells in response to MIP-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	interleukin 10	Homo sapiens	67-72
12711332-6	2003	PD098059, U0126, and LY294002 also attenuated chemotaxis of GM-CSF/IL-10-primed U937 cells in response to MIP-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	C-C motif chemokine ligand 3	Homo sapiens	106-116
12711332-10	2003	PD098059 and U0126 completely abrogated ERK2 phosphorylation; whereas, LY294002 completely blocked PKB/Akt and p70(S6k) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	ribosomal protein S6 kinase B1	Homo sapiens	111-118
12537539-7	2003	Interestingly, this insulin-induced stimulatory effect on mNAT3 expression was attenuated by the phosphoinositide 3-kinase inhibitor LY294002, but not by the mitogen-activated protein kinase inhibitor PD98059, although both kinases were fully activated by insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	N-acetyltransferase 3	Mus musculus	58-63
12697668-9	2003	In addition, phosphatidylinositol 3"-kinase inhibitor, LY294002 or wortmannin, strongly inhibited R1881-induced pro-MMP-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	matrix metallopeptidase 2	Homo sapiens	116-121
12731064-7	2003	All TGF-beta 1-mediated effects, but Bcl2 up-regulation, can be reproduced by the LY294002 phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor but not by inhibitors of the MAPK/ERK (MEK) and Janus kinase (Jak)/STAT pathways, which promote cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	transforming growth factor beta 1	Homo sapiens	4-14
12750770-7	2003	The PI 3-kinase inhibitor LY294002 and the mTOR inhibitor rapamycin, but not the MEK1 inhibitor PD98059, could prevent IRS1 changes in oxidized cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	insulin receptor substrate 1	Rattus norvegicus	119-123
12731064-7	2003	All TGF-beta 1-mediated effects, but Bcl2 up-regulation, can be reproduced by the LY294002 phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor but not by inhibitors of the MAPK/ERK (MEK) and Janus kinase (Jak)/STAT pathways, which promote cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	BCL2 apoptosis regulator	Homo sapiens	37-41
12731064-7	2003	All TGF-beta 1-mediated effects, but Bcl2 up-regulation, can be reproduced by the LY294002 phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor but not by inhibitors of the MAPK/ERK (MEK) and Janus kinase (Jak)/STAT pathways, which promote cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	91-120
12731064-7	2003	All TGF-beta 1-mediated effects, but Bcl2 up-regulation, can be reproduced by the LY294002 phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor but not by inhibitors of the MAPK/ERK (MEK) and Janus kinase (Jak)/STAT pathways, which promote cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	128-131
12731064-7	2003	All TGF-beta 1-mediated effects, but Bcl2 up-regulation, can be reproduced by the LY294002 phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor but not by inhibitors of the MAPK/ERK (MEK) and Janus kinase (Jak)/STAT pathways, which promote cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	mitogen-activated protein kinase 1	Homo sapiens	176-179
12731064-7	2003	All TGF-beta 1-mediated effects, but Bcl2 up-regulation, can be reproduced by the LY294002 phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor but not by inhibitors of the MAPK/ERK (MEK) and Janus kinase (Jak)/STAT pathways, which promote cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	mitogen-activated protein kinase kinase 7	Homo sapiens	181-184
12717386-7	2003	The PI3K inhibitor LY294002 and the mitogen-activated protein kinase kinase (MEK) inhibitor UO126 prevented ADAM12 induction by TGF-beta, suggesting the involvement of PI3K and MEK activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	transforming growth factor beta 1	Homo sapiens	128-136
12717386-7	2003	The PI3K inhibitor LY294002 and the mitogen-activated protein kinase kinase (MEK) inhibitor UO126 prevented ADAM12 induction by TGF-beta, suggesting the involvement of PI3K and MEK activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	ADAM metallopeptidase domain 12	Homo sapiens	108-114
12717386-7	2003	The PI3K inhibitor LY294002 and the mitogen-activated protein kinase kinase (MEK) inhibitor UO126 prevented ADAM12 induction by TGF-beta, suggesting the involvement of PI3K and MEK activities.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	mitogen-activated protein kinase kinase 7	Homo sapiens	177-180
12784909-4	2003	Thus, these investigations were conducted to delineate signal transduction mechanisms of CCL11, CCL24 and CCL26-induced eosinophil peroxidase (EPO) degranulation following pretreatment of cells with or without a specific inhibitor of MEK1/MEK2 (U0126), inhibitor of p38 MAP kinase (SB203580) or a specific inhibitor of PI 3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	332-340	C-C motif chemokine ligand 11	Homo sapiens	89-94
12754302-8	2003	Consistent with these observations, phospho-AKT remained detectable in erbB-2 cells treated with LY294002 or expressing exogenous PTEN, but was abolished by treatment with the p38MAP kinase inhibitor SB202190.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	44-47
12784909-4	2003	Thus, these investigations were conducted to delineate signal transduction mechanisms of CCL11, CCL24 and CCL26-induced eosinophil peroxidase (EPO) degranulation following pretreatment of cells with or without a specific inhibitor of MEK1/MEK2 (U0126), inhibitor of p38 MAP kinase (SB203580) or a specific inhibitor of PI 3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	332-340	C-C motif chemokine ligand 26	Homo sapiens	106-111
12784909-4	2003	Thus, these investigations were conducted to delineate signal transduction mechanisms of CCL11, CCL24 and CCL26-induced eosinophil peroxidase (EPO) degranulation following pretreatment of cells with or without a specific inhibitor of MEK1/MEK2 (U0126), inhibitor of p38 MAP kinase (SB203580) or a specific inhibitor of PI 3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	332-340	eosinophil peroxidase	Homo sapiens	120-141
12784909-4	2003	Thus, these investigations were conducted to delineate signal transduction mechanisms of CCL11, CCL24 and CCL26-induced eosinophil peroxidase (EPO) degranulation following pretreatment of cells with or without a specific inhibitor of MEK1/MEK2 (U0126), inhibitor of p38 MAP kinase (SB203580) or a specific inhibitor of PI 3-kinase (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	332-340	eosinophil peroxidase	Homo sapiens	143-146
12652650-3	2003	The P2Y2-stimulated c-Fos induction was partly blocked (a) by U73122, a phospholipase C inhibitor, (b) by Go6976, a conventional PKC inhibitor, (c) by PD098059, a mitogen-activated protein kinase kinase inhibitor, and, moreover, (d) by the inhibitors of phosphoinositide 3-kinases (PI3K), LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	289-297	purinergic receptor P2Y2	Homo sapiens	4-8
12652650-3	2003	The P2Y2-stimulated c-Fos induction was partly blocked (a) by U73122, a phospholipase C inhibitor, (b) by Go6976, a conventional PKC inhibitor, (c) by PD098059, a mitogen-activated protein kinase kinase inhibitor, and, moreover, (d) by the inhibitors of phosphoinositide 3-kinases (PI3K), LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	289-297	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-25
12754302-8	2003	Consistent with these observations, phospho-AKT remained detectable in erbB-2 cells treated with LY294002 or expressing exogenous PTEN, but was abolished by treatment with the p38MAP kinase inhibitor SB202190.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	71-77
12719789-5	2003	RhoA activation was abolished by cell treatment with two unrelated, structurally distinct, specific inhibitors of PI3-K, wortmannin, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	ras homolog family member A	Homo sapiens	0-4
12719789-7	2003	Thus, selective Rho kinase inhibitor Y27632 and PI3-K inhibitors wortmannin and LY294002 prevented the uPA-induced stimulation of MLC phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	plasminogen activator, urokinase	Homo sapiens	103-106
12719789-7	2003	Thus, selective Rho kinase inhibitor Y27632 and PI3-K inhibitors wortmannin and LY294002 prevented the uPA-induced stimulation of MLC phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	modulator of VRAC current 1	Homo sapiens	130-133
12700661-4	2003	These findings are further confirmed by studies showing that specific pharmacological inhibitors of Btk (LFM-A13), PI3-K (LY294002 and Wortmannin) and PLCgamma (U73122) also block cyclin D2 expression and S phase entry following BCR stimulation, as well as triggering apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	cyclin D2	Mus musculus	180-189
12566459-3	2003	Adenovirus-mediated expression of constitutively active cdc42 (CA-cdc42; V12) stimulated 2-deoxyglucose uptake to 56% of the maximal insulin response, and this was blocked by treatment with the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, wortmannin, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	263-271	cell division cycle 42	Homo sapiens	56-61
12566459-3	2003	Adenovirus-mediated expression of constitutively active cdc42 (CA-cdc42; V12) stimulated 2-deoxyglucose uptake to 56% of the maximal insulin response, and this was blocked by treatment with the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, wortmannin, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	263-271	cell division cycle 42	Homo sapiens	66-71
12647306-7	2003	In contrast, inhibition of PI 3-kinase activity by LY294002 blocked the induction of AP activity by OP-1 and OP-1 plus IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	bone morphogenetic protein 7	Homo sapiens	100-104
12647306-7	2003	In contrast, inhibition of PI 3-kinase activity by LY294002 blocked the induction of AP activity by OP-1 and OP-1 plus IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	bone morphogenetic protein 7	Homo sapiens	109-113
12647306-7	2003	In contrast, inhibition of PI 3-kinase activity by LY294002 blocked the induction of AP activity by OP-1 and OP-1 plus IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	insulin-like growth factor 1	Rattus norvegicus	119-124
12682234-5	2003	LY 294002, an inhibitor of PI3K, increased IEX-1S expression induced by TNF-alpha and accelerated TNF-alpha-induced apoptosis in IkappaB-treated Hc cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	tumor necrosis factor	Homo sapiens	72-81
12682234-5	2003	LY 294002, an inhibitor of PI3K, increased IEX-1S expression induced by TNF-alpha and accelerated TNF-alpha-induced apoptosis in IkappaB-treated Hc cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	tumor necrosis factor	Homo sapiens	98-107
12480711-9	2003	Indirect inhibition of AKT activation by the phosphatidylinositol 3-kinase inhibitor LY294002 reversed the blockade of chlorambucil-induced killing by plasma albumin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Homo sapiens	23-26
12681504-5	2003	Amino acid-induced S6K1 activation was inhibited by LY294002 (PI3-kinase inhibitor) and rapamycin (inhibitor of the mammalian target of rapamycin, mTOR), suggesting the involvement of an avian homolog of mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	ribosomal protein S6 kinase B1	Homo sapiens	19-23
12681504-5	2003	Amino acid-induced S6K1 activation was inhibited by LY294002 (PI3-kinase inhibitor) and rapamycin (inhibitor of the mammalian target of rapamycin, mTOR), suggesting the involvement of an avian homolog of mTOR.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	mechanistic target of rapamycin kinase	Homo sapiens	204-208
12657588-12	2003	LY294002 completely blocked the action of FGF-2 on the expression and phosphorylation of p27.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	fibroblast growth factor 2	Oryctolagus cuniculus	42-47
12691830-4	2003	BDNF"s ability to rescue the cells from cisplatin-induced cell death was inhibited by treatment with the Trk tyrosine kinase inhibitor, K252a, and the phosphatidylinositol 3"-kinase (PI)-3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	brain derived neurotrophic factor	Homo sapiens	0-4
12639928-9	2003	Investigation of the role of the protein kinases, PI-3 kinase (PI3K) and MAPK, by use of the inhibitors PD098059 and LY294002 demonstrated that the activation of PI3K, but not MAPK, was required to prevent proapoptotic events in cells exposed to H(2)O(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	50-61
12586735-6	2003	Kv2.1 and Kv1.4 are highly expressed in beta-cells, and in Kv2.1-transfected tsA201 cells, 50 microM LY294002 and 100 microM LY303511 reversibly inhibited currents by 99% and 41%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	potassium voltage-gated channel subfamily B member 1	Homo sapiens	0-5
12586735-6	2003	Kv2.1 and Kv1.4 are highly expressed in beta-cells, and in Kv2.1-transfected tsA201 cells, 50 microM LY294002 and 100 microM LY303511 reversibly inhibited currents by 99% and 41%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	potassium voltage-gated channel subfamily A member 4	Homo sapiens	10-15
12586735-6	2003	Kv2.1 and Kv1.4 are highly expressed in beta-cells, and in Kv2.1-transfected tsA201 cells, 50 microM LY294002 and 100 microM LY303511 reversibly inhibited currents by 99% and 41%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	potassium voltage-gated channel subfamily B member 1	Homo sapiens	59-64
12586735-7	2003	In Kv1.4-transfected tsA201 cells, 50 microM LY294002 reduced the inactivation time constant from 73 to 18 ms.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	potassium voltage-gated channel subfamily A member 4	Homo sapiens	3-8
12586738-6	2003	However, the PI3-K inhibitor Ly294002 resensitizes Lyn-Delta-N cells to apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	51-54
12692267-2	2003	PC3 cells, which lack the lipid phosphatase PTEN, were treated overnight with a reversible inhibitor of the phosphatidylinositol 3-kinase, LY294002 (a treatment which was found to reversibly decrease Akt enzymatic activity).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Homo sapiens	200-203
12927054-7	2003	The phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 reduced both survival and proliferation of NCI-H446 cells (0.48- and 0.27-fold, respectively), even on FN-coated surface.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	fibronectin 1	Homo sapiens	164-166
12927054-10	2003	Adhesion of NCI-H446 cells also increased with FN (4.47-fold) which was abrogated with LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	fibronectin 1	Homo sapiens	47-49
12927054-12	2003	Even in the presence of LY294002, these serine/tyrosine residues were still phosphorylated on FN-coated surface.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	fibronectin 1	Homo sapiens	94-96
12644581-7	2003	The phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002), inhibited ET-1-induced Ca(2+) influx through NSCC-2 and SOCC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-111	endothelin-1	Oryctolagus cuniculus	135-139
12692267-8	2003	These results indicate that LY294002 treatment and washout is a useful method to study the activation of Akt in the context of a tumor cell.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	105-108
12669121-4	2003	Treatment with the p38 inhibitor SB203580 and the PI3K inhibitor LY294002, but not with the MEK1 inhibitor PD98059, abrogated hypoxia-dependent PAI-1 induction in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	serpin family E member 1	Homo sapiens	144-149
12657951-3	2003	METHODOLOGY AND RESULTS: In PK-45H pancreatic cancer cells, the growth-inhibitory and apoptosis-inducing effects of LY294002, a PI3K inhibitor, were detected in a concentration-dependent manner, followed by the reduction of phosphorylated Akt levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	239-242
12514175-5	2003	This effect could be blocked by phosphatidylinositol 3-kinase/Akt pathway inhibitors LY294002 or wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Homo sapiens	62-65
12538595-6	2003	Epo-dependent MAPK activation was also sensitive to the G beta gamma competitive inhibitor beta ARK1-ct (C-terminal fragment of the beta-adrenergic receptor kinase), to the Ras dominant negative mutant RasN17, and to the phosphoinositide 3-kinase (PI3K) inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	erythropoietin	Cricetulus griseus	0-3
12646256-7	2003	Clone 8 and 10 cells secreted vascular endothelial growth factor-A (VEGF-A) more than mock cells and the secretion was PI3-kinase inhibitor, LY294002-sensitive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	vascular endothelial growth factor A	Homo sapiens	30-66
12646256-7	2003	Clone 8 and 10 cells secreted vascular endothelial growth factor-A (VEGF-A) more than mock cells and the secretion was PI3-kinase inhibitor, LY294002-sensitive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	vascular endothelial growth factor A	Homo sapiens	68-74
12538575-3	2003	We examined the function of phosphatidylinositol 3-kinase (PI 3-kinase) in GM-CSF-stimulated glucose uptake and found that PI 3-kinase inhibitors, wortmannin and LY294002, completely blocked the GM-CSF-dependent increase of glucose uptake in Xenopus oocytes expressing the low affinity alpha GMR and in human cells expressing the high affinity alpha beta GMR complex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	28-57
12538575-3	2003	We examined the function of phosphatidylinositol 3-kinase (PI 3-kinase) in GM-CSF-stimulated glucose uptake and found that PI 3-kinase inhibitors, wortmannin and LY294002, completely blocked the GM-CSF-dependent increase of glucose uptake in Xenopus oocytes expressing the low affinity alpha GMR and in human cells expressing the high affinity alpha beta GMR complex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	59-70
12538575-3	2003	We examined the function of phosphatidylinositol 3-kinase (PI 3-kinase) in GM-CSF-stimulated glucose uptake and found that PI 3-kinase inhibitors, wortmannin and LY294002, completely blocked the GM-CSF-dependent increase of glucose uptake in Xenopus oocytes expressing the low affinity alpha GMR and in human cells expressing the high affinity alpha beta GMR complex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	colony stimulating factor 2	Homo sapiens	75-81
12538575-3	2003	We examined the function of phosphatidylinositol 3-kinase (PI 3-kinase) in GM-CSF-stimulated glucose uptake and found that PI 3-kinase inhibitors, wortmannin and LY294002, completely blocked the GM-CSF-dependent increase of glucose uptake in Xenopus oocytes expressing the low affinity alpha GMR and in human cells expressing the high affinity alpha beta GMR complex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	123-134
12538575-3	2003	We examined the function of phosphatidylinositol 3-kinase (PI 3-kinase) in GM-CSF-stimulated glucose uptake and found that PI 3-kinase inhibitors, wortmannin and LY294002, completely blocked the GM-CSF-dependent increase of glucose uptake in Xenopus oocytes expressing the low affinity alpha GMR and in human cells expressing the high affinity alpha beta GMR complex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	colony stimulating factor 2	Homo sapiens	195-201
12538575-3	2003	We examined the function of phosphatidylinositol 3-kinase (PI 3-kinase) in GM-CSF-stimulated glucose uptake and found that PI 3-kinase inhibitors, wortmannin and LY294002, completely blocked the GM-CSF-dependent increase of glucose uptake in Xenopus oocytes expressing the low affinity alpha GMR and in human cells expressing the high affinity alpha beta GMR complex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	292-295
12538575-3	2003	We examined the function of phosphatidylinositol 3-kinase (PI 3-kinase) in GM-CSF-stimulated glucose uptake and found that PI 3-kinase inhibitors, wortmannin and LY294002, completely blocked the GM-CSF-dependent increase of glucose uptake in Xenopus oocytes expressing the low affinity alpha GMR and in human cells expressing the high affinity alpha beta GMR complex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	355-358
12514186-7	2003	Shh-induced capillary morphogenesis was also blocked by LY294002, a phosphoinositide 3-kinase (PI3-kinase) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	sonic hedgehog	Mus musculus	0-3
12502711-5	2003	Both serum- and PDGF-induced Akt phosphorylation was inhibited by LY294002, an inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	AKT serine/threonine kinase 1	Homo sapiens	29-32
12514118-5	2003	Treatment of cells with the phosphatidyl-inositol 3-kinase (PI3-K) inhibitor, LY294002, inhibited Ang-1-induced phosphorylation of Akt, restored the cleavage of the effector caspase-3, and reduced the protective effect of Ang-1 against SD-induced toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	28-58
12576304-3	2003	cPLA(2) activity was inhibited to the same extent (61 +/- 5 to 72 +/- 4%) by the m2 antagonist methoctramine, Gbeta antibody, pertussis toxin, the PI3-kinase inhibitor LY 294002, PAK1 antibody, the p38 MAP kinase inhibitor SB-203580, and a Cdc42/Rac1 GEF (Vav2) antibody and by coexpression of dominant-negative Cdc42 and Rac1 mutants.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-177	phospholipase A2 group IVA	Homo sapiens	0-6
12616480-4	2003	The induction of IL-1beta, but not of MIP-2 or TNF-alpha, was blocked by the PI 3-kinase inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	interleukin 1 beta	Mus musculus	17-25
12616480-4	2003	The induction of IL-1beta, but not of MIP-2 or TNF-alpha, was blocked by the PI 3-kinase inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	77-81
12514118-5	2003	Treatment of cells with the phosphatidyl-inositol 3-kinase (PI3-K) inhibitor, LY294002, inhibited Ang-1-induced phosphorylation of Akt, restored the cleavage of the effector caspase-3, and reduced the protective effect of Ang-1 against SD-induced toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	angiopoietin 1	Homo sapiens	98-103
12514118-5	2003	Treatment of cells with the phosphatidyl-inositol 3-kinase (PI3-K) inhibitor, LY294002, inhibited Ang-1-induced phosphorylation of Akt, restored the cleavage of the effector caspase-3, and reduced the protective effect of Ang-1 against SD-induced toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	AKT serine/threonine kinase 1	Homo sapiens	131-134
12514118-5	2003	Treatment of cells with the phosphatidyl-inositol 3-kinase (PI3-K) inhibitor, LY294002, inhibited Ang-1-induced phosphorylation of Akt, restored the cleavage of the effector caspase-3, and reduced the protective effect of Ang-1 against SD-induced toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	caspase 3	Homo sapiens	174-183
12514118-5	2003	Treatment of cells with the phosphatidyl-inositol 3-kinase (PI3-K) inhibitor, LY294002, inhibited Ang-1-induced phosphorylation of Akt, restored the cleavage of the effector caspase-3, and reduced the protective effect of Ang-1 against SD-induced toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	angiopoietin 1	Homo sapiens	222-227
12493764-3	2003	Thrombin stimulation of the VCAM-1 gene and promoter in human umbilical vein endothelial cells was inhibited by preincubation with the phosphatidylinositol 3-kinase inhibitor, LY294002, the protein kinase C (PKC)-delta inhibitor, rottlerin, a PKC-zeta peptide inhibitor, or by overexpression of dominant negative (DN)-PKC-zeta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	coagulation factor II, thrombin	Homo sapiens	0-8
12584329-7	2003	The phosphatidylinositol 3-kinase inhibitor, LY294002, previously reported to inhibit Nef-mediated MHC-I downmodulation in astrocytic cells, did not directly affect Nef"s ability to block transport of MHC-I to the cell surface in T cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	S100 calcium binding protein B	Homo sapiens	86-89
12646285-6	2003	The two agonists stimulated Akt phosphorylation and the effect was also abolished by beta-FNA and by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Homo sapiens	28-31
12622720-7	2003	Two structurally different inhibitors of phosphatidylinositol 3-kinase, wortmannin and LY294002, inhibited MMP-12 transcriptional activity and AP-1 binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	matrix metallopeptidase 12	Homo sapiens	107-113
12493764-3	2003	Thrombin stimulation of the VCAM-1 gene and promoter in human umbilical vein endothelial cells was inhibited by preincubation with the phosphatidylinositol 3-kinase inhibitor, LY294002, the protein kinase C (PKC)-delta inhibitor, rottlerin, a PKC-zeta peptide inhibitor, or by overexpression of dominant negative (DN)-PKC-zeta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	vascular cell adhesion molecule 1	Homo sapiens	28-34
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	coagulation factor II, thrombin	Homo sapiens	42-50
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	nuclear factor kappa B subunit 1	Homo sapiens	73-82
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	RELA proto-oncogene, NF-kB subunit	Homo sapiens	83-86
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	nuclear factor kappa B subunit 1	Homo sapiens	102-111
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	vascular cell adhesion molecule 1	Homo sapiens	154-160
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	GATA binding protein 2	Homo sapiens	233-239
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	233-237
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	protein kinase C zeta	Homo sapiens	297-305
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-288	coagulation factor II, thrombin	Homo sapiens	42-50
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-288	nuclear factor kappa B subunit 1	Homo sapiens	73-82
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-288	RELA proto-oncogene, NF-kB subunit	Homo sapiens	83-86
12493764-4	2003	In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-288	vascular cell adhesion molecule 1	Homo sapiens	154-160
12589802-4	2003	Furthermore, cross-linking of alpha4beta1 induced activation of the Rho family small GTPase Rac, which was enhanced by induced overexpression of CrkL and was inhibited by the phosphatidylinositol 3(")-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	225-233	thymoma viral proto-oncogene 1	Mus musculus	92-95
12644311-3	2003	CaR-dependent ERK activation was blocked by co-expression of the Ras dominant-negative mutant, Ras N17, and by exposure to the phosphatidyl inositol 3" kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	calcium sensing receptor	Homo sapiens	0-3
12644311-3	2003	CaR-dependent ERK activation was blocked by co-expression of the Ras dominant-negative mutant, Ras N17, and by exposure to the phosphatidyl inositol 3" kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	mitogen activated protein kinase 1	Rattus norvegicus	14-17
12644312-0	2003	The phosphatidylinositol 3-kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17beta-estradiol-induced transcriptional activity of an estrogen sensitive reporter gene.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	estrogen receptor 1	Homo sapiens	63-80
12644312-5	2003	Phosphorylation of this residue is inhibited by LY294002, which blocks the PI3-kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	86-89
12589789-6	2003	U0126 and LY294002 abolished ERK1/2 and Akt phosphorylation, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	mitogen-activated protein kinase 3	Homo sapiens	29-35
12589789-6	2003	U0126 and LY294002 abolished ERK1/2 and Akt phosphorylation, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	40-43
12589802-4	2003	Furthermore, cross-linking of alpha4beta1 induced activation of the Rho family small GTPase Rac, which was enhanced by induced overexpression of CrkL and was inhibited by the phosphatidylinositol 3(")-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	225-233	v-crk avian sarcoma virus CT10 oncogene homolog-like	Mus musculus	145-149
12573450-6	2003	The presence of PI3K inhibitor LY 294002 completely abolished the calpain-mediated increase in the activity of PI3K-C2beta but did not prevent the gel shift.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-40	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	Homo sapiens	111-122
12574380-5	2003	Pretreatment with LY294002, a PI3K inhibitor, strongly suppressed group IIA PLA(2)-induced iNOS expression and PI3K/Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	76-82
12592384-7	2003	MT1-MMP induction and invasion were blocked by the PI 3-kinase inhibitors LY294002 and wortmannin and by rapamycin, but not by the MEK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	0-7
12406867-9	2003	Interestingly, full rescue of G-CSF-induced neutrophilic differentiation was observed when cells were cultured with the mitogen-induced extracellular kinase (MEK) inhibitors, PD98059 or U0126, and partial recovery was detected with the phosphoinositide 3-kinase (PI3-K) inhibitor LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-289	colony stimulating factor 3 (granulocyte)	Mus musculus	30-35
12574380-5	2003	Pretreatment with LY294002, a PI3K inhibitor, strongly suppressed group IIA PLA(2)-induced iNOS expression and PI3K/Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	nitric oxide synthase 2, inducible	Mus musculus	91-95
12590600-4	2003	PKC inhibitor Go6983 and PI3K inhibitors wortmannin and LY294002 all inhibit ERK1/2 activation by AVP, but not by FGF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	mitogen-activated protein kinase 3	Mus musculus	77-83
12574380-5	2003	Pretreatment with LY294002, a PI3K inhibitor, strongly suppressed group IIA PLA(2)-induced iNOS expression and PI3K/Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	thymoma viral proto-oncogene 1	Mus musculus	116-119
12590600-4	2003	PKC inhibitor Go6983 and PI3K inhibitors wortmannin and LY294002 all inhibit ERK1/2 activation by AVP, but not by FGF2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	arginine vasopressin	Mus musculus	98-101
12574380-6	2003	The promoter activity of iNOS was stimulated by group IIA PLA(2), and this was suppressed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	nitric oxide synthase 2, inducible	Mus musculus	25-29
12574380-9	2003	Overexpression of M-type sPLA(2)R enhanced group IIA PLA(2)-induced promoter activity and iNOS protein expression, and these effects were abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	26-32
12574380-9	2003	Overexpression of M-type sPLA(2)R enhanced group IIA PLA(2)-induced promoter activity and iNOS protein expression, and these effects were abolished by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	nitric oxide synthase 2, inducible	Mus musculus	90-94
12529253-5	2003	ET-1-induced Ca(2+) influx was partially inhibited in CHO-ET(B)R pretreated with wortmannin or LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-104	endothelin-1	Cricetulus griseus	0-4
12446712-5	2003	Treatment of LMP1-expressing cells with the PI3K inhibitor LY294002 resulted in decreased cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	PDZ and LIM domain 7	Homo sapiens	13-17
12529253-6	2003	In contrast, addition of wortmannin or LY-294002 after stimulation with ET-1 did not suppress Ca(2+) influx.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-48	endothelin-1	Cricetulus griseus	72-76
12527329-8	2003	The PI3K inhibitor LY294002 (50 microM) inhibited PKB phosphorylation in both cells lines, but only induced apoptosis in the MDA-MB-468 line.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	50-53
12529253-7	2003	The Ca(2+) channels activated by ET-1 in wortmannin- or LY-294002-treated CHO-ET(B)R were sensitive to LOE 908 and resistant to SK&amp;F 96365.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-65	endothelin-1	Cricetulus griseus	33-37
12540485-5	2003	This effect of hypoxia is mediated by the phosphatidylinositol 3-kinase (PI3-K) signaling pathway because the presence of the PI3-K inhibitors, LY294002 and wortmannin, during pre-exposure to hypoxia completely blocks subsequent protection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	42-71
12475887-11	2003	BTC-induced tube formation was suppressed by PD98059, wortmannin, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	betacellulin	Homo sapiens	0-3
12529294-5	2003	We subsequently investigated the signal transduction pathways involved in ROS generation and demonstrated that fMLP-stimulated ROS production was inhibited by the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002, but not by the MAPK/ERK kinase (MEK) inhibitor U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	formyl peptide receptor 1	Homo sapiens	111-115
12529294-6	2003	In contrast, ROS production induced by fMLP stimulation of GM-CSF-primed cells was inhibited by LY294002 and U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	formyl peptide receptor 1	Homo sapiens	39-43
12529294-6	2003	In contrast, ROS production induced by fMLP stimulation of GM-CSF-primed cells was inhibited by LY294002 and U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	colony stimulating factor 2	Homo sapiens	59-65
12578538-6	2003	Wortmannin and LY 294002 blocked IGF-I stimulated progesterone secretion, but PD 98059 was without effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	insulin like growth factor 1	Sus scrofa	33-38
12630817-8	2003	The promoting action of AM on endothelial migration was also suppressed by LY294002, an inhibitor for phosphatidylinositol 3-kinase, but not by N(G)-nitro-L-arginine-methyl ester (L-NAME), an antagonist for nitric oxide synthase (NOS).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	nitric oxide synthase 2	Homo sapiens	207-228
12588890-9	2003	Albumin-induced ROS generation, NF-kappaB activation, and IL-8 secretion were endocytosis- and PKC-dependent as these downstream events were abrogated by the PI3K inhibitors LY294002 and wortmannin, and the PKC inhibitors GF109203X and staurosporin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	albumin	Homo sapiens	0-7
12588890-9	2003	Albumin-induced ROS generation, NF-kappaB activation, and IL-8 secretion were endocytosis- and PKC-dependent as these downstream events were abrogated by the PI3K inhibitors LY294002 and wortmannin, and the PKC inhibitors GF109203X and staurosporin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	nuclear factor kappa B subunit 1	Homo sapiens	32-41
12588890-9	2003	Albumin-induced ROS generation, NF-kappaB activation, and IL-8 secretion were endocytosis- and PKC-dependent as these downstream events were abrogated by the PI3K inhibitors LY294002 and wortmannin, and the PKC inhibitors GF109203X and staurosporin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
12592338-5	2003	In contrast, AR cells were resistant to TRAIL concentrations as high as 2 microg/ml for 24 h. Two pharmacological inhibitors of PI3K, Ly294002 and wortmannin, restored TRAIL sensitivity of AR cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	TNF superfamily member 10	Homo sapiens	40-45
12592338-5	2003	In contrast, AR cells were resistant to TRAIL concentrations as high as 2 microg/ml for 24 h. Two pharmacological inhibitors of PI3K, Ly294002 and wortmannin, restored TRAIL sensitivity of AR cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	TNF superfamily member 10	Homo sapiens	168-173
12555073-5	2003	Notably, in this paper we show that IGF-I alone induces a potent JNK response and this activity is reversed by inhibition of phosphatidylinositol 3-kinase (PI 3-kinase) with LY294002 in MCF-7 but not T47D cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	insulin like growth factor 1	Homo sapiens	36-41
12555073-5	2003	Notably, in this paper we show that IGF-I alone induces a potent JNK response and this activity is reversed by inhibition of phosphatidylinositol 3-kinase (PI 3-kinase) with LY294002 in MCF-7 but not T47D cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	174-182	mitogen-activated protein kinase 8	Homo sapiens	65-68
12555073-10	2003	The inhibitory effect of JNK appears to be mediated by serine phosphorylation of IRS-1 (insulin receptor substrate) since both Taxol and IGF-I treatment enhanced Ser(312) IRS-1 phosphorylation, while LY294002 blocked IGF-I-mediated phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	mitogen-activated protein kinase 8	Homo sapiens	25-28
12555073-10	2003	The inhibitory effect of JNK appears to be mediated by serine phosphorylation of IRS-1 (insulin receptor substrate) since both Taxol and IGF-I treatment enhanced Ser(312) IRS-1 phosphorylation, while LY294002 blocked IGF-I-mediated phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	insulin receptor substrate 1	Homo sapiens	81-86
12555073-10	2003	The inhibitory effect of JNK appears to be mediated by serine phosphorylation of IRS-1 (insulin receptor substrate) since both Taxol and IGF-I treatment enhanced Ser(312) IRS-1 phosphorylation, while LY294002 blocked IGF-I-mediated phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	insulin like growth factor 1	Homo sapiens	137-142
12554807-4	2003	The PI-3K inhibitor LY294002 specifically inhibited cell survival in the presence of the chimera, suggesting a key role of this enzyme in the potentiation of survival caused by the linkage of IGF and IL-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	interleukin 3	Homo sapiens	200-204
12504093-5	2003	Treatment of these cells with a PI 3-kinase inhibitor LY294002 suppressed apoptosis-inhibitory effects of IRS-1 and IRS-3 as well as the phosphorylation of PKB and FKHRL1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	insulin receptor substrate 1	Cricetulus griseus	106-111
12376540-3	2003	Strikingly, a substantial proportion of LL5beta became associated with an unidentified intracellular vesicle population in the context of low PtdIns(3,4,5)P(3) levels produced by the addition of wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	209-217	pleckstrin homology like domain family B member 2	Homo sapiens	40-47
12543789-8	2003	The prevention of rapamycin-induced apoptosis by IGF-I was not inhibited by expression of dominant-negative Akt either alone or under conditions in which LY 294002 inhibited PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-163	insulin like growth factor 1	Homo sapiens	49-54
12504093-5	2003	Treatment of these cells with a PI 3-kinase inhibitor LY294002 suppressed apoptosis-inhibitory effects of IRS-1 and IRS-3 as well as the phosphorylation of PKB and FKHRL1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	insulin receptor substrate 3, pseudogene	Homo sapiens	116-121
12407113-4	2003	Two unrelated inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY294002, totally prevented Rap1B activation in platelets stimulated by cross-linking of FcgammaRIIA, by stimulation of the P2Y(12) receptor for ADP, or by epinephrine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	RAP1B, member of RAS oncogene family	Homo sapiens	109-114
12414810-5	2003	SDF-1 also stimulated tube formation of human umbilical endothelial cells, and the response was LY294002-sensitive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	C-X-C motif chemokine ligand 12	Homo sapiens	0-5
12407113-4	2003	Two unrelated inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY294002, totally prevented Rap1B activation in platelets stimulated by cross-linking of FcgammaRIIA, by stimulation of the P2Y(12) receptor for ADP, or by epinephrine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	Fc gamma receptor IIa	Homo sapiens	170-181
12522079-3	2003	2 alpha(2) Adrenoceptor-mediated vasoconstriction and ERK2 activation in the porcine palmar lateral vein was inhibited in the presence of either the PI 3-kinase inhibitor LY294002, or the EGF receptor tyrosine kinase inhibitor AG1478 suggesting the involvement of both PI 3-kinase and EGF receptor transactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	mitogen-activated protein kinase 1	Homo sapiens	54-58
12522079-3	2003	2 alpha(2) Adrenoceptor-mediated vasoconstriction and ERK2 activation in the porcine palmar lateral vein was inhibited in the presence of either the PI 3-kinase inhibitor LY294002, or the EGF receptor tyrosine kinase inhibitor AG1478 suggesting the involvement of both PI 3-kinase and EGF receptor transactivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	epidermal growth factor receptor	Homo sapiens	269-297
12789537-6	2003	LY294002 partially inhibited the activation of Akt, and significantly decreased the number of surviving RGCs as compared with that of injury alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	47-50
12517803-6	2003	Treatment of U87MG cells with LY294002, a PI3K inhibitor, or cotransfection with a vector expressing wild-type PTEN decreased VEGF promoter activity using reporters containing either 1.5 kb of the promoter or a fragment extending from -88 to +54 bp.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	phosphatase and tensin homolog	Homo sapiens	111-115
12517803-6	2003	Treatment of U87MG cells with LY294002, a PI3K inhibitor, or cotransfection with a vector expressing wild-type PTEN decreased VEGF promoter activity using reporters containing either 1.5 kb of the promoter or a fragment extending from -88 to +54 bp.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	vascular endothelial growth factor A	Homo sapiens	126-130
12876381-5	2003	Furthermore, EGF and TGFalpha stimulated phosphorylation of Akt, a downstream target of the PI3-kinase pathway, and the PI3-kinase inhibitors wortmannin and LY294002 blocked the EGF-induced DNA synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
12595244-5	2003	An inhibitor of phosphatidylinositol 3-kinase, LY294002, also inhibited NTF-induced VR1 upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	neurotrophin 3	Rattus norvegicus	72-75
12546364-5	2003	The LY294002 inhibited the growth of U87MG cells associated with reduced phosphatidylinositol 3,4,5,-trisphosphate and phosphorylated Akt, and also induced growth inhibition in three other cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	AKT serine/threonine kinase 1	Homo sapiens	134-137
12546364-8	2003	The LY294002 significantly augmented the cytotoxicity induced by etoposide in PTEN-deficient cells, but not in PTEN-wt cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	phosphatase and tensin homolog	Homo sapiens	78-82
12506100-11	2003	SB203580 and LY294002 specifically inhibited the activity of p38 MAP kinase and Akt, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	mitogen activated protein kinase 14	Rattus norvegicus	61-75
12506100-11	2003	SB203580 and LY294002 specifically inhibited the activity of p38 MAP kinase and Akt, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	80-83
12595244-5	2003	An inhibitor of phosphatidylinositol 3-kinase, LY294002, also inhibited NTF-induced VR1 upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	84-87
12556562-4	2003	In vitro AKT1 activity was elevated in resistant cells, whereas treatment of the resistant cell clone with two inhibitors of PI3K, wortmannin or Ly294002, strongly reduced phosphatidylinositol (3,4,5) trisphosphate levels and AKT1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	AKT serine/threonine kinase 1	Homo sapiens	9-13
12393899-5	2002	Furthermore, cortical neuron apoptosis induced by LY294002-mediated activation of endogenous GSK3beta was blocked by expression of constitutively active MKK1 or by BDNF via stimulation of the endogenous ERK1/2 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	glycogen synthase kinase 3 beta	Homo sapiens	93-101
12556562-4	2003	In vitro AKT1 activity was elevated in resistant cells, whereas treatment of the resistant cell clone with two inhibitors of PI3K, wortmannin or Ly294002, strongly reduced phosphatidylinositol (3,4,5) trisphosphate levels and AKT1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	AKT serine/threonine kinase 1	Homo sapiens	226-230
14643763-3	2003	Activation of myelin DAGK by IL-2 occurred in brain stem tissue mince and was blocked by chelerythrin chloride, indicating an essential role for myelin-localized protein kinase C. Two inhibitors of PI3K, wortmannin and LY294002, blocked endogenous PI3K as well as that enhanced by IL-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	diacylglycerol kinase, theta	Mus musculus	21-25
14643763-3	2003	Activation of myelin DAGK by IL-2 occurred in brain stem tissue mince and was blocked by chelerythrin chloride, indicating an essential role for myelin-localized protein kinase C. Two inhibitors of PI3K, wortmannin and LY294002, blocked endogenous PI3K as well as that enhanced by IL-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	interleukin 2	Mus musculus	29-33
12393899-5	2002	Furthermore, cortical neuron apoptosis induced by LY294002-mediated activation of endogenous GSK3beta was blocked by expression of constitutively active MKK1 or by BDNF via stimulation of the endogenous ERK1/2 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	mitogen-activated protein kinase kinase 1	Homo sapiens	153-157
12393899-5	2002	Furthermore, cortical neuron apoptosis induced by LY294002-mediated activation of endogenous GSK3beta was blocked by expression of constitutively active MKK1 or by BDNF via stimulation of the endogenous ERK1/2 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	brain derived neurotrophic factor	Homo sapiens	164-168
12393899-5	2002	Furthermore, cortical neuron apoptosis induced by LY294002-mediated activation of endogenous GSK3beta was blocked by expression of constitutively active MKK1 or by BDNF via stimulation of the endogenous ERK1/2 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	mitogen-activated protein kinase 3	Homo sapiens	203-209
12372835-5	2002	Two unrelated phosphatidylinositol 3-kinase inhibitors, LY294002 and wortmannin, retained endocytosed transferrin in early endosomes but did not affect transfer through recycling endosomes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	transferrin	Homo sapiens	102-113
12486161-3	2002	We used the reversible phosphoinositide-3 kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one [LY294002 (LY)] and we examined its effects by intracellular recording, fluorescence imaging with styryl dyes (FM 1-43 and FM 2-10), calcium imaging, and electron microscopy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	neuromedin U receptor 1	Homo sapiens	238-245
12486161-3	2002	We used the reversible phosphoinositide-3 kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one [LY294002 (LY)] and we examined its effects by intracellular recording, fluorescence imaging with styryl dyes (FM 1-43 and FM 2-10), calcium imaging, and electron microscopy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-118	neuromedin U receptor 1	Homo sapiens	238-245
12486161-3	2002	We used the reversible phosphoinositide-3 kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one [LY294002 (LY)] and we examined its effects by intracellular recording, fluorescence imaging with styryl dyes (FM 1-43 and FM 2-10), calcium imaging, and electron microscopy.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-114	neuromedin U receptor 1	Homo sapiens	238-245
12372835-6	2002	The inhibitory effects of LY294002 and dynamin-1(G273D) on transferrin recycling were additive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	transferrin	Homo sapiens	59-70
12372835-7	2002	In combination with brefeldin A, a drug that prevents the formation of clathrin-coated buds at recycling endosomes, LY294002 inhibited transferrin recycling synergistically.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	transferrin	Homo sapiens	135-146
12444071-12	2002	Western blot analysis confirmed that LY294002 and PD98509 inhibited phosphorylation of Akt and ERK1/ERK2, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	87-90
12444071-12	2002	Western blot analysis confirmed that LY294002 and PD98509 inhibited phosphorylation of Akt and ERK1/ERK2, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	mitogen-activated protein kinase 3	Homo sapiens	95-99
12444071-12	2002	Western blot analysis confirmed that LY294002 and PD98509 inhibited phosphorylation of Akt and ERK1/ERK2, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	mitogen-activated protein kinase 1	Homo sapiens	100-104
12473596-6	2002	RESULTS: LY294002 suppressed growth and decreased expression of Akt (Ser(473)) expression in cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	64-67
12464013-5	2002	Wortmannin and LY294002, inhibitors of PI3-K, reduced alphavbeta3/IAP-upregulated, CR3-associated bacterial binding to human monocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	CD47 molecule	Homo sapiens	66-69
12460191-6	2002	Inhibition of PI-3 kinase activity and Akt phosphorylation with LY294002 totally suppressed IGF-1-mediated protection from Fas killing in activated T cells, but only partially suppressed IGF-1-mediated protection in Jurkat/IGF-1R cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Homo sapiens	39-42
12482504-3	2002	RESULTS: Treatment with LY294002 (a selective pharmacological inhibitor of phosphatidylinositol 3-kinase) significantly inhibited EPO protein and mRNA expression in Hep3B cells exposed to hypoxia for 24 hours, while treatment with PD098059 or SB203580 (selective pharmacological inhibitors of the MEK and p38 mitogen-activated protein kinase pathways, respectively) had no significant effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	erythropoietin	Homo sapiens	130-133
12482504-3	2002	RESULTS: Treatment with LY294002 (a selective pharmacological inhibitor of phosphatidylinositol 3-kinase) significantly inhibited EPO protein and mRNA expression in Hep3B cells exposed to hypoxia for 24 hours, while treatment with PD098059 or SB203580 (selective pharmacological inhibitors of the MEK and p38 mitogen-activated protein kinase pathways, respectively) had no significant effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	mitogen-activated protein kinase 14	Homo sapiens	305-308
12482504-4	2002	The activity of AKT, a downstream target of PI3K, was increased by hypoxia and was also inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Homo sapiens	16-19
12447879-6	2002	By using LY294002 and ML-9, which act as phosphatidylinositol 3-kinase (PI3-K) and Akt inhibitors, respectively, we showed that GSK-3beta phosphorylation required PI3-K activation in both cell lines whereas downstream Akt activation was required only in Mahlavu cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	41-70
12447879-6	2002	By using LY294002 and ML-9, which act as phosphatidylinositol 3-kinase (PI3-K) and Akt inhibitors, respectively, we showed that GSK-3beta phosphorylation required PI3-K activation in both cell lines whereas downstream Akt activation was required only in Mahlavu cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	glycogen synthase kinase 3 beta	Homo sapiens	128-137
12460191-6	2002	Inhibition of PI-3 kinase activity and Akt phosphorylation with LY294002 totally suppressed IGF-1-mediated protection from Fas killing in activated T cells, but only partially suppressed IGF-1-mediated protection in Jurkat/IGF-1R cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	insulin like growth factor 1	Homo sapiens	92-97
12460191-6	2002	Inhibition of PI-3 kinase activity and Akt phosphorylation with LY294002 totally suppressed IGF-1-mediated protection from Fas killing in activated T cells, but only partially suppressed IGF-1-mediated protection in Jurkat/IGF-1R cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	insulin like growth factor 1 receptor	Homo sapiens	223-229
12482999-8	2002	LY294002 (PI3K inhibitor) also suppressed MUC2 expression, but did not inhibit any MAPKs phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	42-46
12464678-6	2002	In a ligand-dependent manner, GR activated PI3K and Akt in vitro and in vivo caused NO-dependent vasodilation, which was blocked by cotreatment with RU486 or the PI3K inhibitor LY294002 but not by transcriptional inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	nuclear receptor subfamily 3, group C, member 1	Mus musculus	30-32
12464678-6	2002	In a ligand-dependent manner, GR activated PI3K and Akt in vitro and in vivo caused NO-dependent vasodilation, which was blocked by cotreatment with RU486 or the PI3K inhibitor LY294002 but not by transcriptional inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	thymoma viral proto-oncogene 1	Mus musculus	52-55
12444147-7	2002	Changes in cell polarization and the augmentation of the fMLP-induced superoxide anion generation, by all priming agents were also inhibited by DMS, while only the superoxide anion release was blocked by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	248-256	formyl peptide receptor 1	Homo sapiens	57-61
12444151-3	2002	We found that, in addition to the MAP/Erk kinase inhibitor PD098059, the PI 3-kinase inhibitors LY294002 and wortmannin both suppressed Erk activation in M-CSF-treated monocytes, suggesting that 3-phosphorylated products of PI 3-kinase played a role in Erk activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	mitogen-activated protein kinase 1	Homo sapiens	136-139
12444151-3	2002	We found that, in addition to the MAP/Erk kinase inhibitor PD098059, the PI 3-kinase inhibitors LY294002 and wortmannin both suppressed Erk activation in M-CSF-treated monocytes, suggesting that 3-phosphorylated products of PI 3-kinase played a role in Erk activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	colony stimulating factor 1	Homo sapiens	154-159
12444151-3	2002	We found that, in addition to the MAP/Erk kinase inhibitor PD098059, the PI 3-kinase inhibitors LY294002 and wortmannin both suppressed Erk activation in M-CSF-treated monocytes, suggesting that 3-phosphorylated products of PI 3-kinase played a role in Erk activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	mitogen-activated protein kinase 1	Homo sapiens	136-139
12480916-8	2002	Phosphatidylinositol-3 kinase inhibitor LY 294002 also markedly inhibited the antiapoptotic effect of TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-49	tumor necrosis factor	Homo sapiens	102-111
12480921-6	2002	Substrate-immobilized anti-CD63 antibodies enhanced tumor cell migration and invasion and induced prominent cell surface protrusions that were repressed by the PI3-kinase LY294002 inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	CD63 molecule	Homo sapiens	27-31
12451129-10	2002	Furthermore, EPO-induced neuroprotection as well as phosphorylation of the proapoptotic Bcl family member Bad was reduced by the phosphoinositide-3 kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	erythropoietin	Rattus norvegicus	13-16
12451129-10	2002	Furthermore, EPO-induced neuroprotection as well as phosphorylation of the proapoptotic Bcl family member Bad was reduced by the phosphoinositide-3 kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	129-154
12495471-7	2002	Phosphorylation of Akt was inhibited by the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and the tyrosine kinase inhibitor genistein in KMP-3 and KMP-4 cells, indicating that upstream signals are required for Akt activation in these two cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	AKT serine/threonine kinase 1	Homo sapiens	19-22
12495471-7	2002	Phosphorylation of Akt was inhibited by the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and the tyrosine kinase inhibitor genistein in KMP-3 and KMP-4 cells, indicating that upstream signals are required for Akt activation in these two cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	AKT serine/threonine kinase 1	Homo sapiens	220-223
12606824-4	2002	Regulation of Mcl-1 expression was analyzed with the specific PI3-kinase inhibitors LY294002 and wortmannin and the inhibitor of MAP-kinase activation, PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	14-19
12435806-8	2002	Wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294,002), inhibitors of the phosphatidylinositol 3-kinase (PI3K) signaling pathway, blocked cannabinoid-induced ERK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-63	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	95-124
12435806-8	2002	Wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294,002), inhibitors of the phosphatidylinositol 3-kinase (PI3K) signaling pathway, blocked cannabinoid-induced ERK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-63	mitogen-activated protein kinase 1	Homo sapiens	179-182
12606820-6	2002	Disruption of the anti-apoptotic PI3K pathway by LY294002 (40 microM), its specific inhibitor, caused further significant dissipation of the psi(m) (p&lt; 0.01) and cleavage of caspase-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	caspase 3	Homo sapiens	177-186
12606820-7	2002	EGF was able to maintain the psi(m) and to prevent cleavage of caspase-3 even in the presence of LY294002, indicating that its survival effects were independent of the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	epidermal growth factor	Homo sapiens	0-3
12606824-7	2002	RESULTS: Upregulation of Mcl-1 in human melanoma cells by betulinic acid is mediated via a signal-transduction pathway that is inhibited by LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	25-30
12606824-8	2002	Betulinic acid-induced phosphorylation and activation of the Akt protein kinase was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	61-64
12438669-10	2002	We found that pretreatment with either nitro-L-arginine or LY294002 completely inhibited the vasodilator response to recombinant human VEGF (p &lt; 0.005).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	vascular endothelial growth factor A	Homo sapiens	135-139
12470598-8	2002	The induction of DC21 by IL-12 peaked around 8-12 h, and lasted until 24 h. LY294002 and SB203580 significantly suppressed the IL-12-induced DC21 gene expression, which implies that PI3K and p38/JNK are involved in the IL-12 signal transduction pathway that leads to the DC21 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	17-21
12453151-5	2002	Treatment with phosphoinositide 3(PI3)-kinase inhibitors wortmannin, LY294002 and 3-methyladenine (known to inhibit the autophagic response in interphase cells) rescued autophagy in mitotic cells without inducing reassembly of vesiculated ER and Golgi compartments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	peptidase inhibitor 3	Homo sapiens	34-37
12470598-8	2002	The induction of DC21 by IL-12 peaked around 8-12 h, and lasted until 24 h. LY294002 and SB203580 significantly suppressed the IL-12-induced DC21 gene expression, which implies that PI3K and p38/JNK are involved in the IL-12 signal transduction pathway that leads to the DC21 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	141-145
12470598-8	2002	The induction of DC21 by IL-12 peaked around 8-12 h, and lasted until 24 h. LY294002 and SB203580 significantly suppressed the IL-12-induced DC21 gene expression, which implies that PI3K and p38/JNK are involved in the IL-12 signal transduction pathway that leads to the DC21 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	mitogen-activated protein kinase 14	Homo sapiens	191-194
12470598-8	2002	The induction of DC21 by IL-12 peaked around 8-12 h, and lasted until 24 h. LY294002 and SB203580 significantly suppressed the IL-12-induced DC21 gene expression, which implies that PI3K and p38/JNK are involved in the IL-12 signal transduction pathway that leads to the DC21 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	mitogen-activated protein kinase 8	Homo sapiens	195-198
12470598-8	2002	The induction of DC21 by IL-12 peaked around 8-12 h, and lasted until 24 h. LY294002 and SB203580 significantly suppressed the IL-12-induced DC21 gene expression, which implies that PI3K and p38/JNK are involved in the IL-12 signal transduction pathway that leads to the DC21 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	141-145
12139485-7	2002	Further supporting this idea, we obtained results showing that treatment of cycling NIH 3T3 cells with either wortmannin or LY 294002 induces the accumulation of the transcriptionally repressive p130-E2F4-DP1 complex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-133	transglutaminase 4	Rattus norvegicus	205-208
12429379-3	2002	Inhibition of phosphoinositide 3-kinase with LY294002 decreased phosphorylation and Akt activity, however, pretreatment with LY294002 did not affect glutamate toxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Rattus norvegicus	84-87
12393602-6	2002	Corresponding to enhanced apoptosis, LY294002 down-regulated expression of the antiapoptotic proteins X-linked inhibitor of apoptosis protein (XIAP) and Mcl-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	X-linked inhibitor of apoptosis	Homo sapiens	102-141
12393602-6	2002	Corresponding to enhanced apoptosis, LY294002 down-regulated expression of the antiapoptotic proteins X-linked inhibitor of apoptosis protein (XIAP) and Mcl-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	X-linked inhibitor of apoptosis	Homo sapiens	143-147
12393646-7	2002	BCR/ABL-induced VEGF gene expression was counteracted by the phosphoinositide 3-kinase (PI3-kinase) inhibitor LY294002 and rapamycin, an antagonist of mammalian target of rapamycin (mTOR), but not by inhibition of the mitogen-activated protein kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	mechanistic target of rapamycin kinase	Homo sapiens	182-186
12393646-8	2002	Similarly, BCR/ABL-dependent HIF-1alpha expression was inhibited by the addition of LY294002 and rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	11-18
12235151-4	2002	These responses were inhibited by LY294002 and ML-9, blockers of phosphatidylinositol 3-kinase (PI3K) and Akt, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	AKT serine/threonine kinase 1	Homo sapiens	106-109
12393646-8	2002	Similarly, BCR/ABL-dependent HIF-1alpha expression was inhibited by the addition of LY294002 and rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-39
12438278-8	2002	Treatment of U87MG.DeltaEGFR cells with LY294002, a PI3-K inhibitor, caused reduced levels of phosphorylated Akt and concomitantly up-regulated levels of p27.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	109-112
12438278-8	2002	Treatment of U87MG.DeltaEGFR cells with LY294002, a PI3-K inhibitor, caused reduced levels of phosphorylated Akt and concomitantly up-regulated levels of p27.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	dynactin subunit 6	Homo sapiens	154-157
12393602-6	2002	Corresponding to enhanced apoptosis, LY294002 down-regulated expression of the antiapoptotic proteins X-linked inhibitor of apoptosis protein (XIAP) and Mcl-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	153-158
12393646-7	2002	BCR/ABL-induced VEGF gene expression was counteracted by the phosphoinositide 3-kinase (PI3-kinase) inhibitor LY294002 and rapamycin, an antagonist of mammalian target of rapamycin (mTOR), but not by inhibition of the mitogen-activated protein kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-7
12393646-7	2002	BCR/ABL-induced VEGF gene expression was counteracted by the phosphoinositide 3-kinase (PI3-kinase) inhibitor LY294002 and rapamycin, an antagonist of mammalian target of rapamycin (mTOR), but not by inhibition of the mitogen-activated protein kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	vascular endothelial growth factor A	Homo sapiens	16-20
12420216-10	2002	In colon tumor cells with high Src activity, the PI3 kinase inhibitor LY 294002 sensitized cells to anoikis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-79	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	31-34
12384403-5	2002	The inhibition of MEK1/2 (mitogen-activated protein kinase kinase) by PD98059 or of PI3K (phosphatidylinositol 3-kinase) by Ly294002 abolished the proliferation induced by FGF2, suggesting that ACE cell proliferation required dual signaling through both the extracellular signal-regulated kinase (ERK) and PI3K pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	fibroblast growth factor 2	Cricetulus griseus	172-176
12485853-3	2002	Addition of decorin led to a fourfold increase in phosphorylation of Akt/protein kinase B on Thr307 and a l.4-fold increase on Ser473 after 10 min, but this phosphorylation could not be blocked by preincubation with Ly29400 (10 micro M).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	216-223	Akt1	Drosophila melanogaster	69-72
12384416-3	2002	The activation of Rac-1 induced by cross-linking the BCR or by IL-3 stimulation was blocked only partially by Ly294002, with about 25% to 30% of Rac-1 activation still occurring in the absence of detectable increases in phosphatidyl-inositol-3 kinase (PI-3K) activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	Rac family small GTPase 1	Homo sapiens	18-23
12384416-3	2002	The activation of Rac-1 induced by cross-linking the BCR or by IL-3 stimulation was blocked only partially by Ly294002, with about 25% to 30% of Rac-1 activation still occurring in the absence of detectable increases in phosphatidyl-inositol-3 kinase (PI-3K) activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	BCR activator of RhoGEF and GTPase	Homo sapiens	53-56
12384416-3	2002	The activation of Rac-1 induced by cross-linking the BCR or by IL-3 stimulation was blocked only partially by Ly294002, with about 25% to 30% of Rac-1 activation still occurring in the absence of detectable increases in phosphatidyl-inositol-3 kinase (PI-3K) activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	interleukin 3	Homo sapiens	63-67
12384416-7	2002	In contrast, Ly294002 partially inhibited the activation of p38 MAPK induced by cross-linking of the BCR, although some p38 MAPK activation occurred in the absence of increases in the activity of Rac-1 or PI-3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	BCR activator of RhoGEF and GTPase	Homo sapiens	101-104
12379708-7	2002	IL-8 expression by TNF-alpha was inhibited when two survival signals, nuclear factor kappaB (NF-kappaB) and phosphatidylinositol 3-kinase (PI3K)/Akt, were inhibited by a mutant form of inhibitor of NF-kappaB (IkappaB); by dominant negative (kinase-dead) Akt; or by treatment with LY 294002, an inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-289	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
12414661-12	2002	In contrast, the phosphatidylinositol 3-kinase inhibitor, LY294002, prevented these cells from adhering and completely blocked SCF- and/or SDF-1alpha-induced Akt or p70 S6 kinase phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	KIT ligand	Homo sapiens	127-130
12414661-12	2002	In contrast, the phosphatidylinositol 3-kinase inhibitor, LY294002, prevented these cells from adhering and completely blocked SCF- and/or SDF-1alpha-induced Akt or p70 S6 kinase phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Homo sapiens	158-161
12444902-5	2002	NOS inhibitor N(G)-monomethyl-l-arginine and phosphatidylinositol 3-kinase (PI 3-kinase) inhibitors wortmannin and LY 294002 blunted these effects of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-124	insulin	Homo sapiens	150-157
12423306-7	2002	The effects of IL-3 on apoptosis and CD69 surface expression of human basophils were completely blocked by LY294002 (LY), a potent inhibitor of phosphatidylinositol 3-kinase (PI3-K), but only partially inhibited by lactacystin, a proteasome inhibitor that prevents degradation of IkappaB and NF-kappaB translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	interleukin 3	Homo sapiens	15-19
12423306-7	2002	The effects of IL-3 on apoptosis and CD69 surface expression of human basophils were completely blocked by LY294002 (LY), a potent inhibitor of phosphatidylinositol 3-kinase (PI3-K), but only partially inhibited by lactacystin, a proteasome inhibitor that prevents degradation of IkappaB and NF-kappaB translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	CD69 molecule	Homo sapiens	37-41
12423306-7	2002	The effects of IL-3 on apoptosis and CD69 surface expression of human basophils were completely blocked by LY294002 (LY), a potent inhibitor of phosphatidylinositol 3-kinase (PI3-K), but only partially inhibited by lactacystin, a proteasome inhibitor that prevents degradation of IkappaB and NF-kappaB translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	nuclear factor kappa B subunit 1	Homo sapiens	292-301
12423306-7	2002	The effects of IL-3 on apoptosis and CD69 surface expression of human basophils were completely blocked by LY294002 (LY), a potent inhibitor of phosphatidylinositol 3-kinase (PI3-K), but only partially inhibited by lactacystin, a proteasome inhibitor that prevents degradation of IkappaB and NF-kappaB translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-109	interleukin 3	Homo sapiens	15-19
12423306-7	2002	The effects of IL-3 on apoptosis and CD69 surface expression of human basophils were completely blocked by LY294002 (LY), a potent inhibitor of phosphatidylinositol 3-kinase (PI3-K), but only partially inhibited by lactacystin, a proteasome inhibitor that prevents degradation of IkappaB and NF-kappaB translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-109	CD69 molecule	Homo sapiens	37-41
12423306-7	2002	The effects of IL-3 on apoptosis and CD69 surface expression of human basophils were completely blocked by LY294002 (LY), a potent inhibitor of phosphatidylinositol 3-kinase (PI3-K), but only partially inhibited by lactacystin, a proteasome inhibitor that prevents degradation of IkappaB and NF-kappaB translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-109	nuclear factor kappa B subunit 1	Homo sapiens	292-301
12379708-7	2002	IL-8 expression by TNF-alpha was inhibited when two survival signals, nuclear factor kappaB (NF-kappaB) and phosphatidylinositol 3-kinase (PI3K)/Akt, were inhibited by a mutant form of inhibitor of NF-kappaB (IkappaB); by dominant negative (kinase-dead) Akt; or by treatment with LY 294002, an inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-289	tumor necrosis factor	Homo sapiens	19-28
12379708-7	2002	IL-8 expression by TNF-alpha was inhibited when two survival signals, nuclear factor kappaB (NF-kappaB) and phosphatidylinositol 3-kinase (PI3K)/Akt, were inhibited by a mutant form of inhibitor of NF-kappaB (IkappaB); by dominant negative (kinase-dead) Akt; or by treatment with LY 294002, an inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-289	nuclear factor kappa B subunit 1	Homo sapiens	85-91
12379708-7	2002	IL-8 expression by TNF-alpha was inhibited when two survival signals, nuclear factor kappaB (NF-kappaB) and phosphatidylinositol 3-kinase (PI3K)/Akt, were inhibited by a mutant form of inhibitor of NF-kappaB (IkappaB); by dominant negative (kinase-dead) Akt; or by treatment with LY 294002, an inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-289	nuclear factor kappa B subunit 1	Homo sapiens	93-102
12379708-7	2002	IL-8 expression by TNF-alpha was inhibited when two survival signals, nuclear factor kappaB (NF-kappaB) and phosphatidylinositol 3-kinase (PI3K)/Akt, were inhibited by a mutant form of inhibitor of NF-kappaB (IkappaB); by dominant negative (kinase-dead) Akt; or by treatment with LY 294002, an inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-289	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	108-137
12391586-7	2002	The phosphatidylinositol 3 kinase (PI3K) inhibitor (LY294002) inhibited this neuroprotective effect of bromocriptine, in contrast to the mitogen-activated protein kinase kinase (MAPKK) inhibitor (PD98059), which did not counter the protective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	4-33
12171920-6	2002	BK-stimulated phosphorylation of Ser(617) is Ca(2+)-dependent and is partially inhibited by LY294002 and wortmannin, phosphatidylinositol 3-kinase inhibitors, suggesting signaling via Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	kininogen 1	Bos taurus	0-2
12445202-7	2002	Use of the two phosphotidyl inositol 3-kinase inhibitors, LY294002 and wortmannin, to check whether this pathway is involved in Mcl-1 upregulation by interleukin-6, we found that the phosphotidyl inositol 3-kinase inhibitors completely attenuated the interleukin-6-induced Mcl-1 upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	128-133
12445202-7	2002	Use of the two phosphotidyl inositol 3-kinase inhibitors, LY294002 and wortmannin, to check whether this pathway is involved in Mcl-1 upregulation by interleukin-6, we found that the phosphotidyl inositol 3-kinase inhibitors completely attenuated the interleukin-6-induced Mcl-1 upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	interleukin 6	Homo sapiens	150-163
12445202-7	2002	Use of the two phosphotidyl inositol 3-kinase inhibitors, LY294002 and wortmannin, to check whether this pathway is involved in Mcl-1 upregulation by interleukin-6, we found that the phosphotidyl inositol 3-kinase inhibitors completely attenuated the interleukin-6-induced Mcl-1 upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	interleukin 6	Homo sapiens	251-264
12445202-7	2002	Use of the two phosphotidyl inositol 3-kinase inhibitors, LY294002 and wortmannin, to check whether this pathway is involved in Mcl-1 upregulation by interleukin-6, we found that the phosphotidyl inositol 3-kinase inhibitors completely attenuated the interleukin-6-induced Mcl-1 upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	273-278
12391262-4	2002	tert-Butylhydroquinone (t-BHQ) caused Nrf2 to translocate into the nucleus in H4IIE cells, which was prevented by pretreatment of the cells with PI3-kinase inhibitors (wortmannin/LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	NFE2 like bZIP transcription factor 2	Rattus norvegicus	38-42
12495557-4	2002	The p38 MAPK inhibitor SB203580, the MAPK/extracellular signal-regulated kinase kinase inhibitor PD98059 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 potentiated the staurosporine-induced PARP cleavage and DNA fragmentation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	mitogen-activated protein kinase 14	Mus musculus	4-12
12495557-4	2002	The p38 MAPK inhibitor SB203580, the MAPK/extracellular signal-regulated kinase kinase inhibitor PD98059 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 potentiated the staurosporine-induced PARP cleavage and DNA fragmentation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	113-142
12495557-4	2002	The p38 MAPK inhibitor SB203580, the MAPK/extracellular signal-regulated kinase kinase inhibitor PD98059 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 potentiated the staurosporine-induced PARP cleavage and DNA fragmentation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	poly (ADP-ribose) polymerase family, member 1	Mus musculus	207-211
12438947-11	2002	Akt activation; increase in islet viability; and decrease in Bad phosphorylation, cytochrome release, caspase-9 activation, and translocation of FKHR were observed after simvastatin treatment, effects reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	AKT serine/threonine kinase 1	Homo sapiens	0-3
12498789-6	2002	The protective effects of lithium in vitro were blocked by LY294002, an inhibitor of the phosphatidylinositol 3-kinase/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	thymoma viral proto-oncogene 1	Mus musculus	119-122
12438947-11	2002	Akt activation; increase in islet viability; and decrease in Bad phosphorylation, cytochrome release, caspase-9 activation, and translocation of FKHR were observed after simvastatin treatment, effects reversed by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	213-221	caspase 9	Homo sapiens	102-111
12171932-6	2002	On the other hand, LY294002 and wortmannin, specific inhibitors of PI3K, prevented PDGF-BB-induced phosphorylation of Akt and its downstream effector molecules, p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	AKT serine/threonine kinase 1	Homo sapiens	118-121
12386814-7	2002	Treatment with LY294002, a specific inhibitor of Akt activator, phosphatidylinositol 3-kinase, also induced apoptosis in a dose dependent manner in the control cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	AKT serine/threonine kinase 1	Homo sapiens	49-52
12193593-6	2002	LY294002 and rapamycin, potent inhibitors of PI3-kinase and mTOR, respectively, also blocked the DNA synthesis induced by 5(S)-HETE.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	60-64
12171932-6	2002	On the other hand, LY294002 and wortmannin, specific inhibitors of PI3K, prevented PDGF-BB-induced phosphorylation of Akt and its downstream effector molecules, p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	ribosomal protein S6 kinase B1	Homo sapiens	161-167
12361705-8	2002	ROS-induced PKB activation was abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002, suggesting that PI3-K is an upstream mediator of PKB activation in 7721 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	protein tyrosine kinase 2 beta	Homo sapiens	12-15
12171932-6	2002	On the other hand, LY294002 and wortmannin, specific inhibitors of PI3K, prevented PDGF-BB-induced phosphorylation of Akt and its downstream effector molecules, p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	eukaryotic translation initiation factor 4E	Homo sapiens	203-208
12361705-8	2002	ROS-induced PKB activation was abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002, suggesting that PI3-K is an upstream mediator of PKB activation in 7721 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	48-77
12244132-8	2002	LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, inhibits HGF-induced PAK4 kinase activation, relocalisation, and cell rounding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hepatocyte growth factor	Canis lupus familiaris	65-68
12361705-8	2002	ROS-induced PKB activation was abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002, suggesting that PI3-K is an upstream mediator of PKB activation in 7721 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	protein tyrosine kinase 2 beta	Homo sapiens	155-158
12244132-8	2002	LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, inhibits HGF-induced PAK4 kinase activation, relocalisation, and cell rounding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	p21 (RAC1) activated kinase 4	Canis lupus familiaris	77-81
12372343-8	2002	Furthermore, selective chemical blockers for MEK1 and P13-K (PD98059 and LY294002) inhibited EGF-mediated induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	mitogen-activated protein kinase kinase 1	Mus musculus	45-49
12244132-9	2002	However, the isolated C-terminal kinase domain of PAK4 can induce cell rounding in the presence of LY294002, suggesting that the N-terminal region acts as a negative regulator of PAK4 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	p21 (RAC1) activated kinase 4	Canis lupus familiaris	50-54
12372343-8	2002	Furthermore, selective chemical blockers for MEK1 and P13-K (PD98059 and LY294002) inhibited EGF-mediated induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	epidermal growth factor	Mus musculus	93-96
12372346-7	2002	In addition, the EGF-induced phosphorylation of caveolin-1 in A431 cells was blocked by the Src kinase antagonists PP1 and PP2, but not by the MEK inhibitor PD98059, the phosphoinositide 3-kinase inhibitors LY294002 and wortmannin, or cytoskeleton-disrupting agents, such as cytochalasin D, colchicine, and nocadazole.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	caveolin 1	Homo sapiens	48-58
12372346-7	2002	In addition, the EGF-induced phosphorylation of caveolin-1 in A431 cells was blocked by the Src kinase antagonists PP1 and PP2, but not by the MEK inhibitor PD98059, the phosphoinositide 3-kinase inhibitors LY294002 and wortmannin, or cytoskeleton-disrupting agents, such as cytochalasin D, colchicine, and nocadazole.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	92-95
12384526-5	2002	Importantly, UV-induced increases in p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424) were dramatically inhibited by pretreatment of cells with rapamycin, LY294002, or PD98059, whereas overexpression of dominant-negative mutants of PKClambda/iota and Akt1 did not inhibit p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	ubiquitin associated and SH3 domain containing B	Homo sapiens	37-40
12372346-7	2002	In addition, the EGF-induced phosphorylation of caveolin-1 in A431 cells was blocked by the Src kinase antagonists PP1 and PP2, but not by the MEK inhibitor PD98059, the phosphoinositide 3-kinase inhibitors LY294002 and wortmannin, or cytoskeleton-disrupting agents, such as cytochalasin D, colchicine, and nocadazole.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	123-126
12384526-5	2002	Importantly, UV-induced increases in p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424) were dramatically inhibited by pretreatment of cells with rapamycin, LY294002, or PD98059, whereas overexpression of dominant-negative mutants of PKClambda/iota and Akt1 did not inhibit p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	ribosomal protein S6 kinase B1	Homo sapiens	41-44
12384526-5	2002	Importantly, UV-induced increases in p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424) were dramatically inhibited by pretreatment of cells with rapamycin, LY294002, or PD98059, whereas overexpression of dominant-negative mutants of PKClambda/iota and Akt1 did not inhibit p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	AKT serine/threonine kinase 1	Homo sapiens	261-265
12384526-5	2002	Importantly, UV-induced increases in p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424) were dramatically inhibited by pretreatment of cells with rapamycin, LY294002, or PD98059, whereas overexpression of dominant-negative mutants of PKClambda/iota and Akt1 did not inhibit p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	ubiquitin associated and SH3 domain containing B	Homo sapiens	282-285
12384526-5	2002	Importantly, UV-induced increases in p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424) were dramatically inhibited by pretreatment of cells with rapamycin, LY294002, or PD98059, whereas overexpression of dominant-negative mutants of PKClambda/iota and Akt1 did not inhibit p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	ribosomal protein S6 kinase B1	Homo sapiens	286-289
12169689-6	2002	Pretreatment of HT1080-derived fibrosarcoma cells with pharmacological inhibitors of PI3K (wortmannin or LY294002) selectively inhibited IFN-beta-induced beta-R1 mRNA accumulation in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	interferon beta-1	Bos taurus	137-145
12169689-11	2002	Furthermore, IFN-beta-mediated phosphorylation of GST-p65 was blocked by pretreatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	interferon beta-1	Bos taurus	13-21
12169689-11	2002	Furthermore, IFN-beta-mediated phosphorylation of GST-p65 was blocked by pretreatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	synaptotagmin 1	Bos taurus	54-57
12225969-6	2002	Preincubation with wortmannin or LY-294002 completely blocked TSH activation of p70 S6K and PKB/Akt, implicating phosphoinositide 3-kinase (PI3K) in their regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-42	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	80-87
12363409-6	2002	Inhibition of p38 kinase with 5 micro M SB203540, inhibition of MEK-ERK with 50 micro M U0126, or inhibition of phosphatidylinositol-3-kinase (PI3K) with 10 micro M LY294002 reduced cell viability by 4, 18 or 37%, respectively, after 24 h. All three kinase inhibitors increased cell death in response to 24 h of MPP(+), with the greatest effect shown by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-173	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	112-141
12370824-6	2002	PI3-kinase inhibitors, wortmannin and LY294002, both enhanced FGF-2-dependent uPA production by these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	fibroblast growth factor 2	Mus musculus	62-67
12370824-6	2002	PI3-kinase inhibitors, wortmannin and LY294002, both enhanced FGF-2-dependent uPA production by these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	plasminogen activator, urokinase	Mus musculus	78-81
12225947-4	2002	Pretreatment of cells with wortmannin and LY-294002, inhibitors of PI3K, or rapamycin, an inhibitor of the mammalian target of rapamycin kinase and p70S6K, diminished the ANG IV-mediated activation of PDK-1 and PKB-alpha as well as phosphorylation of p70S6K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-51	ribosomal protein S6 kinase B1	Homo sapiens	148-154
12225947-4	2002	Pretreatment of cells with wortmannin and LY-294002, inhibitors of PI3K, or rapamycin, an inhibitor of the mammalian target of rapamycin kinase and p70S6K, diminished the ANG IV-mediated activation of PDK-1 and PKB-alpha as well as phosphorylation of p70S6K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-51	pyruvate dehydrogenase kinase 1	Homo sapiens	201-206
12372612-2	2002	A significant increase in the activity of immunoprecipitated PI3K-C2beta was observed in the nuclei and nuclear envelopes isolated from all-trans-retinoic acid (ATRA)-differentiated cells which was inhibited by the presence of PI3K inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-251	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	Homo sapiens	61-72
12217904-8	2002	The response was completely blocked by treatment with LY-294002 and partially blocked by rapamycin, thus demonstrating a dependence on phosphatidylinositol 3-kinase and mTOR function, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-63	mechanistic target of rapamycin kinase	Rattus norvegicus	169-173
12225947-4	2002	Pretreatment of cells with wortmannin and LY-294002, inhibitors of PI3K, or rapamycin, an inhibitor of the mammalian target of rapamycin kinase and p70S6K, diminished the ANG IV-mediated activation of PDK-1 and PKB-alpha as well as phosphorylation of p70S6K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-51	AKT serine/threonine kinase 1	Homo sapiens	211-220
12225969-6	2002	Preincubation with wortmannin or LY-294002 completely blocked TSH activation of p70 S6K and PKB/Akt, implicating phosphoinositide 3-kinase (PI3K) in their regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-42	thymoma viral proto-oncogene 1	Mus musculus	92-95
12225947-4	2002	Pretreatment of cells with wortmannin and LY-294002, inhibitors of PI3K, or rapamycin, an inhibitor of the mammalian target of rapamycin kinase and p70S6K, diminished the ANG IV-mediated activation of PDK-1 and PKB-alpha as well as phosphorylation of p70S6K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-51	ribosomal protein S6 kinase B1	Homo sapiens	251-257
12225969-6	2002	Preincubation with wortmannin or LY-294002 completely blocked TSH activation of p70 S6K and PKB/Akt, implicating phosphoinositide 3-kinase (PI3K) in their regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-42	thymoma viral proto-oncogene 1	Mus musculus	96-99
12239175-4	2002	Coincubation with the PI3-kinase inhibitor LY294002, which in parallel experiments abolished GM-CSF-primed, fMLP-stimulated superoxide anion production and GM-CSF-stimulated PtdIns(3,4,5)P(3) accumulation, inhibited the GM-CSF and TNF-alpha survival effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	colony stimulating factor 2	Homo sapiens	93-99
12239175-4	2002	Coincubation with the PI3-kinase inhibitor LY294002, which in parallel experiments abolished GM-CSF-primed, fMLP-stimulated superoxide anion production and GM-CSF-stimulated PtdIns(3,4,5)P(3) accumulation, inhibited the GM-CSF and TNF-alpha survival effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	formyl peptide receptor 1	Homo sapiens	108-112
12239175-4	2002	Coincubation with the PI3-kinase inhibitor LY294002, which in parallel experiments abolished GM-CSF-primed, fMLP-stimulated superoxide anion production and GM-CSF-stimulated PtdIns(3,4,5)P(3) accumulation, inhibited the GM-CSF and TNF-alpha survival effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	colony stimulating factor 2	Homo sapiens	156-162
12239175-4	2002	Coincubation with the PI3-kinase inhibitor LY294002, which in parallel experiments abolished GM-CSF-primed, fMLP-stimulated superoxide anion production and GM-CSF-stimulated PtdIns(3,4,5)P(3) accumulation, inhibited the GM-CSF and TNF-alpha survival effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	colony stimulating factor 2	Homo sapiens	156-162
12239175-4	2002	Coincubation with the PI3-kinase inhibitor LY294002, which in parallel experiments abolished GM-CSF-primed, fMLP-stimulated superoxide anion production and GM-CSF-stimulated PtdIns(3,4,5)P(3) accumulation, inhibited the GM-CSF and TNF-alpha survival effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	tumor necrosis factor	Homo sapiens	231-240
12239175-9	2002	LY294002 inhibited GM-CSF- and TNF-alpha-mediated changes in Bad phosphorylation and mRNA levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	colony stimulating factor 2	Homo sapiens	19-25
12239175-9	2002	LY294002 inhibited GM-CSF- and TNF-alpha-mediated changes in Bad phosphorylation and mRNA levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Homo sapiens	31-40
12135708-3	2002	We showed that phosphatidylinositol 3-kinase (PtdIns 3-kinase) inhibitor LY294002 inhibits Epo-induced hydrolysis of endogenous GPI and Epo-induced PLC-gamma2 tyrosine phosphorylation in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	erythropoietin	Mus musculus	91-94
12135708-5	2002	We also present evidence that PLC-gamma2 translocation to the membrane fraction on Epo stimulation is completely inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	phospholipase C, gamma 2	Mus musculus	30-40
12135708-3	2002	We showed that phosphatidylinositol 3-kinase (PtdIns 3-kinase) inhibitor LY294002 inhibits Epo-induced hydrolysis of endogenous GPI and Epo-induced PLC-gamma2 tyrosine phosphorylation in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	erythropoietin	Mus musculus	136-139
12135708-5	2002	We also present evidence that PLC-gamma2 translocation to the membrane fraction on Epo stimulation is completely inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	erythropoietin	Mus musculus	83-86
12135708-3	2002	We showed that phosphatidylinositol 3-kinase (PtdIns 3-kinase) inhibitor LY294002 inhibits Epo-induced hydrolysis of endogenous GPI and Epo-induced PLC-gamma2 tyrosine phosphorylation in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	phospholipase C, gamma 2	Mus musculus	148-158
12135708-7	2002	LY294002 cell preincubation did not affect GAB2, SHC and SHP2 tyrosine phosphorylation but inhibited the binding of PLC-gamma2 to GAB2 and SHP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phospholipase C, gamma 2	Mus musculus	116-126
12243747-3	2002	Both basal and HGF-stimulated motility of the extravillous trophoblast cell line, SGHPL-4, were inhibited in a dose-dependent manner by the phosphatidylinositol-3-kinase (PI3-kinase) inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	hepatocyte growth factor	Homo sapiens	15-18
12135708-7	2002	LY294002 cell preincubation did not affect GAB2, SHC and SHP2 tyrosine phosphorylation but inhibited the binding of PLC-gamma2 to GAB2 and SHP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	growth factor receptor bound protein 2-associated protein 2	Mus musculus	130-134
12135708-7	2002	LY294002 cell preincubation did not affect GAB2, SHC and SHP2 tyrosine phosphorylation but inhibited the binding of PLC-gamma2 to GAB2 and SHP2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	139-143
12394246-4	2002	We show here that (i) growth inhibition of breast cancer cells by progesterone is due to the induction of cell differentiation and not to apoptosis; (ii) progesterone activates the PI3-kinase/Akt pathway as shown by the increase in the phosphorylation of Akt protein; (iii) inhibiting PI3-kinase/Akt pathway with LY294002 causes stimulation of apoptosis; and (v) progesterone enhances LY294002 induced-growth inhibition and apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	313-321	AKT serine/threonine kinase 1	Homo sapiens	192-195
12394246-4	2002	We show here that (i) growth inhibition of breast cancer cells by progesterone is due to the induction of cell differentiation and not to apoptosis; (ii) progesterone activates the PI3-kinase/Akt pathway as shown by the increase in the phosphorylation of Akt protein; (iii) inhibiting PI3-kinase/Akt pathway with LY294002 causes stimulation of apoptosis; and (v) progesterone enhances LY294002 induced-growth inhibition and apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	385-393	AKT serine/threonine kinase 1	Homo sapiens	192-195
12243747-4	2002	HGF-stimulated iNOS expression was also inhibited by LY294002 and direct activation of PI3-kinase, using the peptide 740Y-P, led to an increase in iNOS expression and cell motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	hepatocyte growth factor	Homo sapiens	0-3
12243747-4	2002	HGF-stimulated iNOS expression was also inhibited by LY294002 and direct activation of PI3-kinase, using the peptide 740Y-P, led to an increase in iNOS expression and cell motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	nitric oxide synthase 2	Homo sapiens	15-19
12356841-10	2002	Moreover, administration of U0126 and LY294002 decreased significantly, but only partially, the neuroprotective effect of BDNF on the axotomized RGCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	brain-derived neurotrophic factor	Rattus norvegicus	122-126
12611639-9	2002	In response to HGF, SCLC moved much faster and formed more clusters, and this was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	hepatocyte growth factor	Homo sapiens	15-18
12611639-10	2002	Finally, we determined the downstream signal transduction of HGF stimulation of c-Met with and without inhibition of c-Met (with geldanamycin, an anisamycin antibiotic that inhibits c-Met in SCLC) or PI3K (with LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	211-219	hepatocyte growth factor	Homo sapiens	61-64
12351720-10	2002	Finally, administration of an inhibitor of phosphatidylinositol 3-kinase (LY294002), thought to be an upstream activator of Akt, exacerbated cortical apoptosis after seizures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Rattus norvegicus	124-127
12107166-7	2002	Both MAP kinase and phosphatidylinositol (PI) 3-kinase cascades in NIH3T3 cells were activated by PTN, and this effect persisted for up to 3 h. Surprisingly, the anti-apoptotic effect of PTN was completely blocked by the MAP kinase inhibitor UO126, but was not affected by the PI 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	299-307	pleiotrophin	Mus musculus	98-101
12481421-3	2002	Exposure of the cells to two structurally distinct inhibitors of PI3k (worthmannin and LY294002) resulted in a dose-dependent induction of apoptosis in six of seven of the cell lines that displayed constitutive AKT phosphorylation but not in either of the cell lines that did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Homo sapiens	211-214
12481421-5	2002	Exposure of orthotopic L3.6pl pancreatic tumors to LY294002 resulted in dose-dependent inhibition of tumor growth, and decreased peritoneal and liver metastases, effects that were associated with an inhibition of AKT phosphorylation and increased terminal deoxynucleotidyl transferase-mediated nick end labeling staining characteristic of apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Homo sapiens	213-216
12105209-3	2002	Using phosphoinositide 3-kinase (PI3-kinase) inhibitor LY294002 and Src inhibitor PP2, we show that interleukin (IL)-18-induced ERK1/2 activation is Src kinase-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	interleukin 18	Homo sapiens	100-119
12242656-6	2002	In human growth factor-independent MM cell lines OPM2 and RPMI8226, we show that the PI 3-K inhibitors LY294002 and Wortmannin strongly inhibited cell proliferation, whereas inhibition of the mammalian Target Of Rapamycin (mTOR)/P70-S6-kinase (P70(S6K)) pathway with rapamycin or of the Mitogen-Activated Protein Kinase (MAPK) pathway with PD98059 had minimal effect on proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	mechanistic target of rapamycin kinase	Homo sapiens	223-227
12242656-6	2002	In human growth factor-independent MM cell lines OPM2 and RPMI8226, we show that the PI 3-K inhibitors LY294002 and Wortmannin strongly inhibited cell proliferation, whereas inhibition of the mammalian Target Of Rapamycin (mTOR)/P70-S6-kinase (P70(S6K)) pathway with rapamycin or of the Mitogen-Activated Protein Kinase (MAPK) pathway with PD98059 had minimal effect on proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	ribosomal protein S6 kinase B1	Homo sapiens	229-232
12242656-8	2002	LY294002 inhibited phosphorylation of Akt, FKHRL-1 and P70(S6K) but had no effect on ERK1/2 phosphorylation, indicating that the PI 3-K and MAPK pathways are independent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	38-41
12242656-8	2002	LY294002 inhibited phosphorylation of Akt, FKHRL-1 and P70(S6K) but had no effect on ERK1/2 phosphorylation, indicating that the PI 3-K and MAPK pathways are independent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	forkhead box O3	Homo sapiens	43-50
12242656-8	2002	LY294002 inhibited phosphorylation of Akt, FKHRL-1 and P70(S6K) but had no effect on ERK1/2 phosphorylation, indicating that the PI 3-K and MAPK pathways are independent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribosomal protein S6 kinase B1	Homo sapiens	55-58
12242656-11	2002	In three of them including the two patients with PCL, constitutive phosphorylation of Akt, FKHRL-1 and P70(S6K) was present, inhibited by LY294002 and enhanced by IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	AKT serine/threonine kinase 1	Homo sapiens	86-89
12242656-11	2002	In three of them including the two patients with PCL, constitutive phosphorylation of Akt, FKHRL-1 and P70(S6K) was present, inhibited by LY294002 and enhanced by IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	forkhead box O3	Homo sapiens	91-98
12242656-11	2002	In three of them including the two patients with PCL, constitutive phosphorylation of Akt, FKHRL-1 and P70(S6K) was present, inhibited by LY294002 and enhanced by IGF-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	ribosomal protein S6 kinase B1	Homo sapiens	103-106
12242656-15	2002	In the presence of LY294002, cell-cycle arrest in G0/G1 was observed, p27(Kip1) protein expression was up-regulated whereas the expression of both Skp2 and cyclin D1 dramatically diminished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	interferon alpha inducible protein 27	Homo sapiens	70-73
12242656-15	2002	In the presence of LY294002, cell-cycle arrest in G0/G1 was observed, p27(Kip1) protein expression was up-regulated whereas the expression of both Skp2 and cyclin D1 dramatically diminished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	cyclin dependent kinase inhibitor 1B	Homo sapiens	74-78
12242656-15	2002	In the presence of LY294002, cell-cycle arrest in G0/G1 was observed, p27(Kip1) protein expression was up-regulated whereas the expression of both Skp2 and cyclin D1 dramatically diminished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	S-phase kinase associated protein 2	Homo sapiens	147-151
12133829-6	2002	The inhibitory pathway from TrkA to RhoA involves phosphatidylinositol-3-kinase (PI3K), because the inhibitors LY294002 or wortmannin prevented NGF-induced RhoA translocation and increased RhoA association with ROK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	28-32
12133829-6	2002	The inhibitory pathway from TrkA to RhoA involves phosphatidylinositol-3-kinase (PI3K), because the inhibitors LY294002 or wortmannin prevented NGF-induced RhoA translocation and increased RhoA association with ROK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	ras homolog family member A	Rattus norvegicus	36-40
12133829-6	2002	The inhibitory pathway from TrkA to RhoA involves phosphatidylinositol-3-kinase (PI3K), because the inhibitors LY294002 or wortmannin prevented NGF-induced RhoA translocation and increased RhoA association with ROK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	nerve growth factor	Rattus norvegicus	144-147
12133829-6	2002	The inhibitory pathway from TrkA to RhoA involves phosphatidylinositol-3-kinase (PI3K), because the inhibitors LY294002 or wortmannin prevented NGF-induced RhoA translocation and increased RhoA association with ROK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	ras homolog family member A	Rattus norvegicus	156-160
12133829-6	2002	The inhibitory pathway from TrkA to RhoA involves phosphatidylinositol-3-kinase (PI3K), because the inhibitors LY294002 or wortmannin prevented NGF-induced RhoA translocation and increased RhoA association with ROK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	ras homolog family member A	Rattus norvegicus	156-160
12133829-6	2002	The inhibitory pathway from TrkA to RhoA involves phosphatidylinositol-3-kinase (PI3K), because the inhibitors LY294002 or wortmannin prevented NGF-induced RhoA translocation and increased RhoA association with ROK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	211-214
12167664-3	2002	Here we show that insulin or insulin growth factor (IGF) 1 stimulates phosphorylation of tuberin, which is inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 but not by the mitogen-activated protein kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	insulin like growth factor 1	Homo sapiens	29-58
12167664-3	2002	Here we show that insulin or insulin growth factor (IGF) 1 stimulates phosphorylation of tuberin, which is inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 but not by the mitogen-activated protein kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	TSC complex subunit 2	Homo sapiens	89-96
12105209-3	2002	Using phosphoinositide 3-kinase (PI3-kinase) inhibitor LY294002 and Src inhibitor PP2, we show that interleukin (IL)-18-induced ERK1/2 activation is Src kinase-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	mitogen-activated protein kinase 3	Homo sapiens	128-134
12167664-3	2002	Here we show that insulin or insulin growth factor (IGF) 1 stimulates phosphorylation of tuberin, which is inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 but not by the mitogen-activated protein kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	124-153
12242656-15	2002	In the presence of LY294002, cell-cycle arrest in G0/G1 was observed, p27(Kip1) protein expression was up-regulated whereas the expression of both Skp2 and cyclin D1 dramatically diminished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	cyclin D1	Homo sapiens	156-165
12105209-3	2002	Using phosphoinositide 3-kinase (PI3-kinase) inhibitor LY294002 and Src inhibitor PP2, we show that interleukin (IL)-18-induced ERK1/2 activation is Src kinase-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	149-152
12105209-6	2002	PI3-kinase inhibitor LY294002 or AS PI3-kinase ODN inhibited Akt expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	61-64
12218155-5	2002	Likewise, LY294002, a PI3-kinase inhibitor, and genistein, a tyrosine kinase inhibitor, caused parallel inhibition of O2- generation and PtdIns(3,4,5)P3 accumulation; in contrast, radicicol, which inhibits receptor-mediated activation of p85 PI3-kinase, had no effect on either response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	238-241
12237112-3	2002	Using specific antibody, we showed that the wortmannin/LY-294002 poorly sensitive phosphoinositide 3-kinase C2alpha is expressed in smooth muscle cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-64	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	82-115
12084724-4	2002	Inhibition of PI 3-kinase activity with the specific inhibitor Ly-294002 prevented BMP-2-induced alkaline phosphatase, an early marker of osteoblast differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-72	peptidase inhibitor 3	Homo sapiens	14-18
12084724-4	2002	Inhibition of PI 3-kinase activity with the specific inhibitor Ly-294002 prevented BMP-2-induced alkaline phosphatase, an early marker of osteoblast differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-72	bone morphogenetic protein 2	Homo sapiens	83-88
12082104-7	2002	Oocytes co-expressing XFGFR1act and XFRS2 showed substantial H1 kinase activity, but this activity was blocked when the oocytes were treated with the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	fibroblast growth factor receptor 1 S homeolog	Xenopus laevis	22-28
12087097-3	2002	Interference with the Akt cascade either by treatment with PI-3K inhibitor (wortmannin or LY294002) or by exogenous expression of a dominant negative Akt in SW626 cells caused decreased cell viability following treatment with paclitaxel.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 1	Homo sapiens	22-25
12204896-4	2002	Attenuation of the p44/42 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3"-kinase (PI 3"-kinase) pathways downstream of the IGF-I receptor using the inhibitors PD98059 and LY294002, respectively, partially reversed IGF-I-induced inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	191-199	interferon induced protein 44	Homo sapiens	19-22
12087097-11	2002	We demonstrated an association between Akt and Raf-1 and showed that the phosphorylation of Raf-1 on Ser-259 induced by paclitaxel was blocked by treatment with wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	AKT serine/threonine kinase 1	Homo sapiens	39-42
12087097-11	2002	We demonstrated an association between Akt and Raf-1 and showed that the phosphorylation of Raf-1 on Ser-259 induced by paclitaxel was blocked by treatment with wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	47-52
12087097-11	2002	We demonstrated an association between Akt and Raf-1 and showed that the phosphorylation of Raf-1 on Ser-259 induced by paclitaxel was blocked by treatment with wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	92-97
12082104-7	2002	Oocytes co-expressing XFGFR1act and XFRS2 showed substantial H1 kinase activity, but this activity was blocked when the oocytes were treated with the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	fibroblast growth factor receptor substrate 2 L homeolog	Xenopus laevis	36-41
12204896-4	2002	Attenuation of the p44/42 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3"-kinase (PI 3"-kinase) pathways downstream of the IGF-I receptor using the inhibitors PD98059 and LY294002, respectively, partially reversed IGF-I-induced inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	191-199	insulin like growth factor 1 receptor	Homo sapiens	143-157
12204896-4	2002	Attenuation of the p44/42 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3"-kinase (PI 3"-kinase) pathways downstream of the IGF-I receptor using the inhibitors PD98059 and LY294002, respectively, partially reversed IGF-I-induced inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	191-199	insulin like growth factor 1	Homo sapiens	143-148
12034359-13	2002	In addition, the specific inhibition of the ERK and the Akt signalling pathways by PD98059 and LY294002, respectively, increased melanin synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	AKT serine/threonine kinase 1	Homo sapiens	56-59
12355490-10	2002	Moreover, calphostin C and LY294002 inhibited the up-regulation of TGF(beta)RI and TGF(beta)RII mRNA, respectively, in SSc fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	transforming growth factor beta receptor 1	Homo sapiens	67-78
12355490-10	2002	Moreover, calphostin C and LY294002 inhibited the up-regulation of TGF(beta)RI and TGF(beta)RII mRNA, respectively, in SSc fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	transforming growth factor beta receptor 2	Homo sapiens	83-95
12225790-4	2002	RESULTS: The PI3K inhibitor LY294002 completely counteracted the EPO-induced proliferation of CD34(+) progenitor cells and CD34(+)CD71(+)CD45RA(-) erythroid progenitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	erythropoietin	Homo sapiens	65-68
12208734-5	2002	Cellular invasion induced by 10 ng/ml stem cell factor (EC(50) = 3 ng/ml) in HT29 cells was blocked by 1 micro M STI571 (IC(50) = 56 nM) and pharmacological inhibitors of several oncogenic signaling pathways, namely, phosphatidylinositol 3-kinase (LY294002), Rho GTPases (Clostridium botulinum exoenzyme C3 transferase), and Rho-kinase (Y27632).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	248-256	KIT ligand	Homo sapiens	38-54
12208743-6	2002	The use of PI3-K inhibitors, Wortmannin or LY-294002, down-regulates the active Akt and reverses cellular resistance to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-52	AKT serine/threonine kinase 1	Homo sapiens	80-83
12208743-6	2002	The use of PI3-K inhibitors, Wortmannin or LY-294002, down-regulates the active Akt and reverses cellular resistance to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-52	TNF superfamily member 10	Homo sapiens	120-125
12034359-13	2002	In addition, the specific inhibition of the ERK and the Akt signalling pathways by PD98059 and LY294002, respectively, increased melanin synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	mitogen-activated protein kinase 1	Homo sapiens	44-47
12034358-5	2002	The apoptosis of SAS cells induced by TNF was dependent on the concentration: a high concentration of TNF, but not a low concentration, induced apoptosis within 30 h. However, a low concentration of TNF in the presence of wortmannin or LY294002 induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	236-244	tumor necrosis factor	Homo sapiens	102-105
12034358-5	2002	The apoptosis of SAS cells induced by TNF was dependent on the concentration: a high concentration of TNF, but not a low concentration, induced apoptosis within 30 h. However, a low concentration of TNF in the presence of wortmannin or LY294002 induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	236-244	tumor necrosis factor	Homo sapiens	102-105
12745435-5	2002	We found the induction of both PAI-1 mRNA and protein, when cells adhered to culture dish, was inhibited by the PI-3 kinase specific inhibitors (Ly294002 and wortmannin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	serpin family E member 1	Homo sapiens	31-36
12225790-4	2002	RESULTS: The PI3K inhibitor LY294002 completely counteracted the EPO-induced proliferation of CD34(+) progenitor cells and CD34(+)CD71(+)CD45RA(-) erythroid progenitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	CD34 molecule	Homo sapiens	94-98
12225790-4	2002	RESULTS: The PI3K inhibitor LY294002 completely counteracted the EPO-induced proliferation of CD34(+) progenitor cells and CD34(+)CD71(+)CD45RA(-) erythroid progenitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	CD34 molecule	Homo sapiens	123-127
12225790-5	2002	LY294002 also highly suppressed the expanded erythropoiesis induced by the combined action of EPO and stem cell factor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	erythropoietin	Homo sapiens	94-97
12225790-5	2002	LY294002 also highly suppressed the expanded erythropoiesis induced by the combined action of EPO and stem cell factor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	KIT ligand	Homo sapiens	102-118
12225790-9	2002	In addition, LY294002 completely blocked the viability-enhancing effect of EPO in CD34(+)CD71(+)CD45RA(-) erythroid progenitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	erythropoietin	Homo sapiens	75-78
12225790-9	2002	In addition, LY294002 completely blocked the viability-enhancing effect of EPO in CD34(+)CD71(+)CD45RA(-) erythroid progenitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	CD34 molecule	Homo sapiens	82-86
12225790-10	2002	LY294002 and various inhibitors of PKC completely suppressed the EPO-induced increase in the activity of Akt kinase, a direct downstream target of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	erythropoietin	Homo sapiens	65-68
12063252-3	2002	The PI3K inhibitor, LY294002, and a tumor suppressor, PTEN, negatively regulate the PI3K/Akt pathway and repress AR activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	89-92
12209089-6	2002	RESULTS: CD40-dependent IgE induction was inhibited by the specific p38 MAPK inhibitor SB203580 but not by the extracellular signal-regulated protein kinase-specific inhibitor PD98059 or the phosphatidylinositol 3-kinase-specific inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	240-248	CD40 molecule	Homo sapiens	9-13
12481412-4	2002	SCF-induced PI3K-Akt activation occurs rapidly but fades within 60 min; IGF-I and FCS-induced activation persists for at least 6 h. SCF and IGF-I-mediated growth was potently inhibited by LY294002 in proportion to its ability to inhibit phosphatidylinositol 3-kinase (PI3K)-Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	KIT ligand	Homo sapiens	0-3
12481412-4	2002	SCF-induced PI3K-Akt activation occurs rapidly but fades within 60 min; IGF-I and FCS-induced activation persists for at least 6 h. SCF and IGF-I-mediated growth was potently inhibited by LY294002 in proportion to its ability to inhibit phosphatidylinositol 3-kinase (PI3K)-Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	insulin like growth factor 1	Homo sapiens	72-77
12481412-4	2002	SCF-induced PI3K-Akt activation occurs rapidly but fades within 60 min; IGF-I and FCS-induced activation persists for at least 6 h. SCF and IGF-I-mediated growth was potently inhibited by LY294002 in proportion to its ability to inhibit phosphatidylinositol 3-kinase (PI3K)-Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	KIT ligand	Homo sapiens	132-135
12481412-4	2002	SCF-induced PI3K-Akt activation occurs rapidly but fades within 60 min; IGF-I and FCS-induced activation persists for at least 6 h. SCF and IGF-I-mediated growth was potently inhibited by LY294002 in proportion to its ability to inhibit phosphatidylinositol 3-kinase (PI3K)-Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	insulin like growth factor 1	Homo sapiens	140-145
12481412-4	2002	SCF-induced PI3K-Akt activation occurs rapidly but fades within 60 min; IGF-I and FCS-induced activation persists for at least 6 h. SCF and IGF-I-mediated growth was potently inhibited by LY294002 in proportion to its ability to inhibit phosphatidylinositol 3-kinase (PI3K)-Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	AKT serine/threonine kinase 1	Homo sapiens	274-277
12481412-7	2002	Because LY294002 can also inhibit PI3K-related enzymes, we confirmed the role of the PI3K-Akt pathway in SCLC using doxycycline-regulated expression of a dominant-negative (kinase dead) and a constitutively active (CA; myristolated) Akt allele.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	AKT serine/threonine kinase 1	Homo sapiens	90-93
12481412-12	2002	The effect of low concentrations of LY294002 could largely be reversed by expression of CA Akt, suggesting that it was mediated by inhibition of Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	91-94
12481412-12	2002	The effect of low concentrations of LY294002 could largely be reversed by expression of CA Akt, suggesting that it was mediated by inhibition of Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	145-148
12243355-6	2002	Furthermore, we demonstrated that specific inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin, and LY294002 blocked the myotube formation and abolished the increase of PKA activity, which normally accompanied the differentiation of myoblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	180-183
12063252-6	2002	Moreover, we show that the repression of AR activity by LY294002 is mediated through phosphorylation and inactivation of GSK3beta, a downstream substrate of PI3K/Akt, which results in the nuclear accumulation of beta-catenin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	glycogen synthase kinase 3 beta	Homo sapiens	121-129
12063252-6	2002	Moreover, we show that the repression of AR activity by LY294002 is mediated through phosphorylation and inactivation of GSK3beta, a downstream substrate of PI3K/Akt, which results in the nuclear accumulation of beta-catenin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	162-165
12063252-6	2002	Moreover, we show that the repression of AR activity by LY294002 is mediated through phosphorylation and inactivation of GSK3beta, a downstream substrate of PI3K/Akt, which results in the nuclear accumulation of beta-catenin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	catenin beta 1	Homo sapiens	212-224
12107064-5	2002	LY-294002 (100 microM) and wortmannin (150 microM), specific inhibitors of phosphatidylinositol 3"-kinase, attenuated IGF-I-induced GSK-3beta phosphorylation by 67 and 92%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	insulin like growth factor 1	Homo sapiens	118-123
12107064-5	2002	LY-294002 (100 microM) and wortmannin (150 microM), specific inhibitors of phosphatidylinositol 3"-kinase, attenuated IGF-I-induced GSK-3beta phosphorylation by 67 and 92%, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	glycogen synthase kinase 3 beta	Homo sapiens	132-141
12154057-7	2002	The PI3K inhibitors LY294002 and wortmannin inhibited CAIX expression in dense cultures in a dose-dependent manner, specifically targeting the CA9 promoter (-173/+31 region) that was transactivated by constitutively active p110 PI3K subunit.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	carbonic anhydrase 9	Homo sapiens	54-58
12139742-4	2002	We evaluated the effects of PI3-K inhibitors (wortmannin and LY294002) on the levels of CD38 antigen and mRNA in HL-60 and normal marrow CD34+ cells exposed to ATRA (1 micromol/l).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	CD38 molecule	Homo sapiens	88-92
12139742-4	2002	We evaluated the effects of PI3-K inhibitors (wortmannin and LY294002) on the levels of CD38 antigen and mRNA in HL-60 and normal marrow CD34+ cells exposed to ATRA (1 micromol/l).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	CD34 molecule	Homo sapiens	137-141
12154057-7	2002	The PI3K inhibitors LY294002 and wortmannin inhibited CAIX expression in dense cultures in a dose-dependent manner, specifically targeting the CA9 promoter (-173/+31 region) that was transactivated by constitutively active p110 PI3K subunit.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	carbonic anhydrase 9	Homo sapiens	143-146
12149431-6	2002	IgE-dependent activation of p38 MAPK and MKK3/6 was affected by LY 294002 and wortmannin, suggesting that these kinases are targets for phosphatidylinositol 3 kinase (PI 3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	mitogen-activated protein kinase kinase 3	Homo sapiens	41-47
12149431-6	2002	IgE-dependent activation of p38 MAPK and MKK3/6 was affected by LY 294002 and wortmannin, suggesting that these kinases are targets for phosphatidylinositol 3 kinase (PI 3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	136-165
12124352-6	2002	Treatment with either Herceptin or the PI3K inhibitor LY294002 increased the levels of p27 in the nucleus&gt;cytosol, thus increasing the ratio of p27:Cdk2 in the nucleus and inhibiting Cdk2 activity and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	interferon alpha inducible protein 27	Homo sapiens	87-90
12163544-4	2002	TGFbeta1-evoked stimulation of K(Ca) channels is blocked by the PI3K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	transforming growth factor beta 1	Gallus gallus	0-8
12400610-9	2002	Pretreatment of REH cells with a P13 kinase/Akt inhibitor LY 294002 did not inhibit RAFTK tyrosine phosphorylation showing that RAFTK is upstream of P13k/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-67	AKT serine/threonine kinase 1	Homo sapiens	44-47
12124352-6	2002	Treatment with either Herceptin or the PI3K inhibitor LY294002 increased the levels of p27 in the nucleus&gt;cytosol, thus increasing the ratio of p27:Cdk2 in the nucleus and inhibiting Cdk2 activity and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	interferon alpha inducible protein 27	Homo sapiens	147-150
12124352-6	2002	Treatment with either Herceptin or the PI3K inhibitor LY294002 increased the levels of p27 in the nucleus&gt;cytosol, thus increasing the ratio of p27:Cdk2 in the nucleus and inhibiting Cdk2 activity and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	cyclin dependent kinase 2	Homo sapiens	151-155
12124352-6	2002	Treatment with either Herceptin or the PI3K inhibitor LY294002 increased the levels of p27 in the nucleus&gt;cytosol, thus increasing the ratio of p27:Cdk2 in the nucleus and inhibiting Cdk2 activity and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	cyclin dependent kinase 2	Homo sapiens	186-190
12124352-8	2002	Transduction of BT-474 cells with an adenovirus-encoding active (myristoylated) Akt (Myr-Akt), but not with a beta-galactosidase control adenovirus, prevented the Herceptin- or LY294002-induced down-regulation of cyclin D1 and of phosphorylated GSK-3beta and prevented the accumulation of p27 in the nucleus and cytosol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	AKT serine/threonine kinase 1	Homo sapiens	80-83
12124352-8	2002	Transduction of BT-474 cells with an adenovirus-encoding active (myristoylated) Akt (Myr-Akt), but not with a beta-galactosidase control adenovirus, prevented the Herceptin- or LY294002-induced down-regulation of cyclin D1 and of phosphorylated GSK-3beta and prevented the accumulation of p27 in the nucleus and cytosol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	AKT serine/threonine kinase 1	Homo sapiens	85-92
12055089-10	2002	However, LY-294002, an inhibitor of phosphoinositide 3-kinase, blocked LIF-induced proliferation of satellite cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-18	LIF, interleukin 6 family cytokine	Rattus norvegicus	71-74
11994280-3	2002	The inhibition of phosphatidylinositol 3-kinase with two unrelated pharmacological inhibitors, wortmannin and LY294002, abrogated both the anti-apoptotic effect and the phosphorylation of AKT induced by Tat.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Homo sapiens	188-191
11994280-3	2002	The inhibition of phosphatidylinositol 3-kinase with two unrelated pharmacological inhibitors, wortmannin and LY294002, abrogated both the anti-apoptotic effect and the phosphorylation of AKT induced by Tat.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	tyrosine aminotransferase	Homo sapiens	203-206
12055097-2	2002	We found that phosphatidylinositol 3-kinase (PI3K) is activated in OSE cells in response to elevated extracellular calcium, and the PI3K inhibitors wortmannin and LY-294002 inhibited extracellular signal-regulated kinase (ERK) activation by approximately 75%, similar to effects of the mitogen-activated protein kinase/ERK kinase inhibitor PD-98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-172	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	14-43
12055097-2	2002	We found that phosphatidylinositol 3-kinase (PI3K) is activated in OSE cells in response to elevated extracellular calcium, and the PI3K inhibitors wortmannin and LY-294002 inhibited extracellular signal-regulated kinase (ERK) activation by approximately 75%, similar to effects of the mitogen-activated protein kinase/ERK kinase inhibitor PD-98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-172	mitogen-activated protein kinase 1	Homo sapiens	183-220
12055097-2	2002	We found that phosphatidylinositol 3-kinase (PI3K) is activated in OSE cells in response to elevated extracellular calcium, and the PI3K inhibitors wortmannin and LY-294002 inhibited extracellular signal-regulated kinase (ERK) activation by approximately 75%, similar to effects of the mitogen-activated protein kinase/ERK kinase inhibitor PD-98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-172	mitogen-activated protein kinase 1	Homo sapiens	222-225
11978789-2	2002	We now demonstrate that GLP-2, in a cycloheximide-insensitive manner, enhanced survival in baby hamster kidney cells stably transfected with the rat GLP-2R; reduced mitochondrial cytochrome c efflux; and attenuated the caspase-dependent cleavage of Akt, poly(ADP-ribose) polymerase, and beta-catenin following inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	364-372	mast cell protease 10	Rattus norvegicus	24-29
11978789-3	2002	The prosurvival effects of GLP-2 on LY294002-induced cell death were independent of Akt, p90(Rsk), or p70 S6 kinase activation; were mimicked by forskolin; and were abrogated by inhibition of protein kinase A (PKA) activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	mast cell protease 10	Rattus norvegicus	27-32
11978789-3	2002	The prosurvival effects of GLP-2 on LY294002-induced cell death were independent of Akt, p90(Rsk), or p70 S6 kinase activation; were mimicked by forskolin; and were abrogated by inhibition of protein kinase A (PKA) activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	192-208
11978789-3	2002	The prosurvival effects of GLP-2 on LY294002-induced cell death were independent of Akt, p90(Rsk), or p70 S6 kinase activation; were mimicked by forskolin; and were abrogated by inhibition of protein kinase A (PKA) activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	210-213
11978789-5	2002	GLP-2 reduced LY294002-induced mitochondrial association of endogenous Bad and Bax and stimulated phosphorylation of a transfected Bad fusion protein at Ser(155) in a PI3K-independent, but H89-sensitive manner, a modification known to suppress Bad pro-apoptotic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	mast cell protease 10	Rattus norvegicus	0-5
11978789-5	2002	GLP-2 reduced LY294002-induced mitochondrial association of endogenous Bad and Bax and stimulated phosphorylation of a transfected Bad fusion protein at Ser(155) in a PI3K-independent, but H89-sensitive manner, a modification known to suppress Bad pro-apoptotic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	BCL2 associated X, apoptosis regulator	Rattus norvegicus	79-82
12114321-5	2002	Inhibition of PI3K with LY294002 or wortmannin enables beta2-AR-PKA signaling to reach intracellular substrates, as manifested by a robust increase in phosphorylation of phospholamban, and markedly enhances the receptor-mediated positive contractile and relaxant responses in cardiac myocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	adrenoceptor beta 2	Homo sapiens	55-63
12055072-7	2002	Inhibition of PI 3-kinase by LY-294002 also inhibited TNF-alpha-mediated antiapoptotic signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-38	tumor necrosis factor	Homo sapiens	54-63
12097303-7	2002	We confirm involvement of PI3k/Akt/NFkappaB signaling because the PI3k inhibitors wortmannin and LY294002 or the inhibitor of NFkappaB (IkappaB) kinase inhibitor PS-1145 block constitutive and cytokine-induced up-regulation of telomerase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	31-34
12174876-6	2002	In contrast, erbB2-overexpressing cells showed statistically significant resistance to cisplatin, the P13K inhibitor LY294002 and the tyrosine kinase inhibitor emodin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	erb-b2 receptor tyrosine kinase 2	Homo sapiens	13-18
12174876-8	2002	Exposure of cells to geldanamycin, 17AAG, emodin, LY294002 and cisplatin led to depletion of erbB2 in the transfected cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	93-98
12055097-2	2002	We found that phosphatidylinositol 3-kinase (PI3K) is activated in OSE cells in response to elevated extracellular calcium, and the PI3K inhibitors wortmannin and LY-294002 inhibited extracellular signal-regulated kinase (ERK) activation by approximately 75%, similar to effects of the mitogen-activated protein kinase/ERK kinase inhibitor PD-98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-172	mitogen-activated protein kinase 1	Homo sapiens	319-322
12097303-7	2002	We confirm involvement of PI3k/Akt/NFkappaB signaling because the PI3k inhibitors wortmannin and LY294002 or the inhibitor of NFkappaB (IkappaB) kinase inhibitor PS-1145 block constitutive and cytokine-induced up-regulation of telomerase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	nuclear factor kappa B subunit 1	Homo sapiens	35-43
12089343-9	2002	Inhibition of PI3-K activities via treatment with LY294002 disrupted Akt activation and interfered with the endocrine differentiation of trophoblast giant cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	69-72
12089369-10	2002	PI3-K inhibition by LY294002 blocked both Akt phosphorylation and superoxide generation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	AKT serine/threonine kinase 1	Homo sapiens	42-45
12089369-12	2002	LY294002 (5 microM) decreased this amount to 0.3 +/- 2.6 nmol (n = 10, P &lt; 0.05); the MPO-ANCA values were 23 +/- 3 versus 1.6 +/- 3.6 (n = 10, P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	myeloperoxidase	Homo sapiens	89-92
12124422-6	2002	Neuroprotection by l-AP4 was attenuated by MSOP and abrogated by the compounds PD98059 and UO126, which inhibit the MAPK pathway, or by the compound LY294002, which inhibits the PI-3-K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	transcription factor AP-4	Homo sapiens	21-24
12115604-8	2002	Further analysis showed that phosphoinositide 3 kinase (PI3K) inhibitors wortmannin and LY294002 inhibit NK cell chemotaxis induced by SPP, DHSPP or RANTES.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	C-C motif chemokine ligand 5	Homo sapiens	149-155
12152651-7	2002	Inhibition of PI3-kinase by two unrelated inhibitors (wortmannin and LY294002) prevented ILK-related functions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	integrin linked kinase	Homo sapiens	89-92
12115344-6	2002	RESULTS: LY294002 significantly affected the proliferation and apoptosis of Colo205 cells, suggesting an association with the low phosphorylation level of Akt protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	155-158
12479367-7	2002	Combining LY294002 with tamoxifen in estrogen receptor-positive cells greatly potentiated apoptosis, which was correlated with tamoxifen-induced Akt phosphorylation that preceded apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Homo sapiens	145-148
12479367-8	2002	To confirm that the effects of LY294002 on chemotherapy-induced apoptosis were attributable to inhibition of Akt, we transiently transfected breast cancer cells with dominant-negative Akt and observed increased doxorubicin-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	109-112
12479367-8	2002	To confirm that the effects of LY294002 on chemotherapy-induced apoptosis were attributable to inhibition of Akt, we transiently transfected breast cancer cells with dominant-negative Akt and observed increased doxorubicin-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	184-187
12479367-3	2002	Akt promoted breast cancer cell survival because a PI3K inhibitor, LY294002, or transient transfection of a dominant-negative Akt mutant inhibited Akt activity and increased apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	AKT serine/threonine kinase 1	Homo sapiens	0-3
12479367-5	2002	Potentiation of apoptosis by LY294002 correlated with induction of Akt by doxorubicin or trastuzumab alone that occurred before the onset of apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	67-70
12070129-3	2002	Inhibition of phosphatidylinositol (PI) 3-kinase by wortmannin (WT) or LY294002 caused the formation of large endosomal vesicles of heterogeneous Rab composition, containing the ligand-receptor complex in their limiting membranes and in small associated vesicular structures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	RAB11A, member RAS oncogene family	Homo sapiens	146-149
11923280-8	2002	The serum-induced increase in p53 ubiquitination was blocked by LY294002, a phosphatidylinositol 3-OH-kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	tumor protein p53	Homo sapiens	30-33
12056817-6	2002	In contrast, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, LY294002, increased its secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	15-44
12051699-8	2002	LY294002, a PI3K inhibitor, reduced PDGF-BB-stimulated MMP-3 expression in PAE cells expressing wild-type PDGF receptors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	matrix metallopeptidase 3	Homo sapiens	55-60
12051724-1	2002	17Beta-estradiol (E2) induces proliferation and c-fos gene expression in MCF-7 cells and both responses are partially blocked by wortmannin and LY294002 which are inhibitors of phosphatidylinositol-3-kinase (PI3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	48-53
12051724-1	2002	17Beta-estradiol (E2) induces proliferation and c-fos gene expression in MCF-7 cells and both responses are partially blocked by wortmannin and LY294002 which are inhibitors of phosphatidylinositol-3-kinase (PI3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	177-206
12056831-5	2002	Lactate dehydrogenase (LDH) assay and Hoechst nucleic staining indicated that U0126, which inhibits Erk1/2 phosphorylation, enhanced ischemia-induced cell death, whereas LY294002, which inhibits Akt phosphorylation, delayed cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	AKT serine/threonine kinase 1	Homo sapiens	195-198
12056831-8	2002	In contrast, LY294002-treated astrocytes expressed a higher level of Bcl-2 than controls as shown by Western blots.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	BCL2 apoptosis regulator	Homo sapiens	69-74
11919181-3	2002	Exposure of cells to 2-20 mm EtOH resulted in rapid (&lt;10 min) induction of Akt phosphorylation that could be prevented by pertussis toxin or the PI3K inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	AKT serine/threonine kinase 1	Homo sapiens	78-81
12051724-2	2002	Analysis of the c-fos gene promoter shows that the effects of wortmannin and LY294002 are associated with inhibition of E2-induced activation through the serum response factor (SRF) motif within the proximal serum response element at -325 and -296.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	16-21
12115180-7	2002	Activation of Akt was blocked by the specific PI 3-kinase inhibitor, LY294002, indicating that TGFbeta-mediated phosphorylation of Akt was dependent on PI 3-kinase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	14-17
12051724-2	2002	Analysis of the c-fos gene promoter shows that the effects of wortmannin and LY294002 are associated with inhibition of E2-induced activation through the serum response factor (SRF) motif within the proximal serum response element at -325 and -296.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	serum response factor	Homo sapiens	154-175
12051724-2	2002	Analysis of the c-fos gene promoter shows that the effects of wortmannin and LY294002 are associated with inhibition of E2-induced activation through the serum response factor (SRF) motif within the proximal serum response element at -325 and -296.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	serum response factor	Homo sapiens	177-180
12051724-3	2002	E2 activates constructs containing multiple copies of the SRF (pSRF) and a GAL4-SRF fusion protein; these responses are accompanied by PI3-K-dependent phosphorylation of Akt and inhibited by wortmannin/LY294002, the antiestrogen ICI 182780, but not by the mitogen-activated protein kinase kinase (MAPKK) inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	serum response factor	Homo sapiens	58-61
12051724-3	2002	E2 activates constructs containing multiple copies of the SRF (pSRF) and a GAL4-SRF fusion protein; these responses are accompanied by PI3-K-dependent phosphorylation of Akt and inhibited by wortmannin/LY294002, the antiestrogen ICI 182780, but not by the mitogen-activated protein kinase kinase (MAPKK) inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	galectin 4	Homo sapiens	75-79
12051724-3	2002	E2 activates constructs containing multiple copies of the SRF (pSRF) and a GAL4-SRF fusion protein; these responses are accompanied by PI3-K-dependent phosphorylation of Akt and inhibited by wortmannin/LY294002, the antiestrogen ICI 182780, but not by the mitogen-activated protein kinase kinase (MAPKK) inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	202-210	AKT serine/threonine kinase 1	Homo sapiens	170-173
12051686-10	2002	Similarly, the PI3K inhibitor LY294002 (10 microM/L) abolished the Ang II-mediated increase in MAPK phosphorylation, as well as phosphoserine-PLA(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	angiotensinogen	Rattus norvegicus	67-73
12051686-12	2002	However, exogenous AA was able to restore VSMC growth in the presence of LY294002, as well as reverse the inhibition of MAPK and cPLA(2) phosphorylation by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	phospholipase A2 group IVA	Rattus norvegicus	129-135
12115180-7	2002	Activation of Akt was blocked by the specific PI 3-kinase inhibitor, LY294002, indicating that TGFbeta-mediated phosphorylation of Akt was dependent on PI 3-kinase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	transforming growth factor beta 1	Homo sapiens	95-102
12115180-7	2002	Activation of Akt was blocked by the specific PI 3-kinase inhibitor, LY294002, indicating that TGFbeta-mediated phosphorylation of Akt was dependent on PI 3-kinase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	AKT serine/threonine kinase 1	Homo sapiens	131-134
12031712-11	2002	HGF-induced iNOS expression was partially abrogated in the presence of the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor LY294002, but not the Src kinase inhibitor, PP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	hepatocyte growth factor	Homo sapiens	0-3
12031712-11	2002	HGF-induced iNOS expression was partially abrogated in the presence of the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor LY294002, but not the Src kinase inhibitor, PP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	nitric oxide synthase 2	Homo sapiens	12-16
12060639-7	2002	Either wortmannin or LY294002, combined with NaBT, enhanced activation of caspase-9 and caspase-3 and the subsequent cleavage of poly(ADP-ribose) polymerase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	caspase 9	Homo sapiens	74-83
12060639-7	2002	Either wortmannin or LY294002, combined with NaBT, enhanced activation of caspase-9 and caspase-3 and the subsequent cleavage of poly(ADP-ribose) polymerase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	caspase 3	Homo sapiens	88-97
12060639-7	2002	Either wortmannin or LY294002, combined with NaBT, enhanced activation of caspase-9 and caspase-3 and the subsequent cleavage of poly(ADP-ribose) polymerase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	poly(ADP-ribose) polymerase 1	Homo sapiens	129-156
12060641-0	2002	The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3"-kinase, in human colon cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	108-138
12060641-2	2002	We postulated that 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a PI3K inhibitor, should inactivate Akt/PKB, consequently inhibiting cell proliferation and inducing apoptosis in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	AKT serine/threonine kinase 1	Homo sapiens	103-110
12060641-6	2002	RESULTS: LY294002 demonstrated a remarkable growth-inhibitory and apoptosis-inducing effect in these colon cancer cell lines, with decreased expression of phosphorylated Akt (Ser(473)).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	170-173
12021190-12	2002	IGF-I- and FSH-dependent AKT phosphorylation was inhibited by LY29400 (10 microM), a PI3K inhibitor, and by IGF-binding protein 3, but not by a PKA inhibitor (H89).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-69	insulin-like growth factor 1	Rattus norvegicus	0-5
12021190-12	2002	IGF-I- and FSH-dependent AKT phosphorylation was inhibited by LY29400 (10 microM), a PI3K inhibitor, and by IGF-binding protein 3, but not by a PKA inhibitor (H89).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-69	AKT serine/threonine kinase 1	Rattus norvegicus	25-28
12006617-6	2002	By using the kinase inhibitors PD98059 and LY294002, we further showed that the activation level of the PI3K and MAPK p42/44 pathways is a determining factor for the proliferative effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	cyclin-dependent kinase 20	Mus musculus	118-121
12068071-7	2002	Pre-treatment of cultures with the PI3-kinase inhibitor LY 294002 demonstrated a dose-dependent decrease in tBHQ-induced hPAP activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-65	regenerating family member 3 alpha	Homo sapiens	121-125
12068071-9	2002	Interestingly, basal expression of Nrf2 was also inhibited by LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-71	nuclear factor, erythroid derived 2, like 2	Mus musculus	35-39
12069900-8	2002	Additionally, the mitogen activated protein (MAP) kinase inhibitor PD98059 enhances BDNF-induced glutamate receptor-1 (GluR1) protein expression, but a phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 strongly reduces BDNF-induced GluR1 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-207	brain derived neurotrophic factor	Homo sapiens	84-88
11884408-8	2002	Similarly, treatment with PI3K inhibitors (wortmannin and LY294002) inhibited the ability of oncogenic H-Ras to enhance DNA repair capacity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	Harvey rat sarcoma virus oncogene	Mus musculus	103-108
11897789-5	2002	In support of this, we found that the PI 3-kinase inhibitors, wortmannin and LY294002, blocked insulin-stimulated but not EGF- or PDGF-stimulated Shc phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	insulin	Homo sapiens	95-102
12032855-5	2002	HER-2/neu-overexpressing breast cancer cell lines were resistant to apoptosis induced by UV treatment and hypoxia, which was suppressed in the presence of the phosphatidylinositol 3-kinase inhibitors LY294002 and wortmannin, indicating a link between AKT activation and stress resistance in HER-2/neu-overexpressing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
12020744-8	2002	Both wortmannin and LY294002 that are phosphatidylinositol (PI) 3-kinase inhibitors, inhibited the SGLT1 activity, and also attenuated the effect of 8-Br-cAMP on SGLT1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	solute carrier family 5 member 1	Homo sapiens	99-104
12020744-8	2002	Both wortmannin and LY294002 that are phosphatidylinositol (PI) 3-kinase inhibitors, inhibited the SGLT1 activity, and also attenuated the effect of 8-Br-cAMP on SGLT1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	solute carrier family 5 member 1	Homo sapiens	162-167
12054696-7	2002	Phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin and LY294002, blocked not only p38 MAPK activation but also Rac activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	0-29
12054696-7	2002	Phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin and LY294002, blocked not only p38 MAPK activation but also Rac activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	mitogen-activated protein kinase 14	Bos taurus	91-94
12032855-5	2002	HER-2/neu-overexpressing breast cancer cell lines were resistant to apoptosis induced by UV treatment and hypoxia, which was suppressed in the presence of the phosphatidylinositol 3-kinase inhibitors LY294002 and wortmannin, indicating a link between AKT activation and stress resistance in HER-2/neu-overexpressing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	erb-b2 receptor tyrosine kinase 2	Homo sapiens	6-9
11971003-5	2002	Adhesion was blocked approximately 75% by inhibition of the phosphatidylinositol-3 kinase (PI3K) pathway with LY294002, supporting that activation of both MAPK and PI3K may play a role in IL-8-dependent inside-out signals that activate Mac-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	60-89
12019180-4	2002	Inhibition of Akt activation in the highly metastatic cell line Li7 by transfection with kinase-dead Akt or the phosphatidylinositol 3-kinase inhibitor, LY294002, resulted in formation of fewer colonies in soft agar than was the case with control cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	AKT serine/threonine kinase 1	Homo sapiens	14-17
12066848-8	2002	During PMA-induced monocytic differentiation, LY294002 inhibited c-jun protein expression and decrease of c-myc protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-70
12066848-8	2002	During PMA-induced monocytic differentiation, LY294002 inhibited c-jun protein expression and decrease of c-myc protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	106-111
12027889-7	2002	The isozyme phosphorylation is also blocked by both wortmannin and LY294002, two structurally different inhibitors of phosphatidyl inositol 3-kinase (PtdIns3K), the enzyme that produces PtdInsP(3) known to activate PLC gamma isozymes specifically by interacting with their SH2 and pleckstrin homology domains.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	heparan sulfate proteoglycan 2	Homo sapiens	215-218
12027889-10	2002	1 alpha,25(OH)(2)D(3)-induced membrane translocation of PLC gamma was prevented to a great extent by c-Src and PtdIns3K inhibitors, PP1 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	heparan sulfate proteoglycan 2	Homo sapiens	56-59
11971003-5	2002	Adhesion was blocked approximately 75% by inhibition of the phosphatidylinositol-3 kinase (PI3K) pathway with LY294002, supporting that activation of both MAPK and PI3K may play a role in IL-8-dependent inside-out signals that activate Mac-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
11971003-5	2002	Adhesion was blocked approximately 75% by inhibition of the phosphatidylinositol-3 kinase (PI3K) pathway with LY294002, supporting that activation of both MAPK and PI3K may play a role in IL-8-dependent inside-out signals that activate Mac-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	integrin subunit beta 2	Homo sapiens	236-241
11971003-6	2002	Activation of MAPK was inhibited in IL-8-stimulated cells in the presence of PI3K inhibitors LY294002 or wortmannin, supporting a model in which PI3K is upstream of MAPK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
12065645-3	2002	Here we show that inhibition of phosphatidylinositol (PI) 3-kinase with LY294002 induces internalization of the human DAT (hDAT), thereby reducing transport capacity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	solute carrier family 6 member 3	Homo sapiens	118-121
12065645-3	2002	Here we show that inhibition of phosphatidylinositol (PI) 3-kinase with LY294002 induces internalization of the human DAT (hDAT), thereby reducing transport capacity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	solute carrier family 6 member 3	Homo sapiens	123-127
12065645-4	2002	Acute treatment with LY294002 reduced the maximal rate of [(3) H]DA uptake in rat striatal synaptosomes and in human embryonic kidney (HEK) 293 cells stably expressing the hDAT (hDAT cells).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	solute carrier family 6 member 3	Homo sapiens	172-176
12065645-4	2002	Acute treatment with LY294002 reduced the maximal rate of [(3) H]DA uptake in rat striatal synaptosomes and in human embryonic kidney (HEK) 293 cells stably expressing the hDAT (hDAT cells).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	solute carrier family 6 member 3	Homo sapiens	178-182
12065645-5	2002	In addition, LY294002 caused a significant redistribution of the hDAT from the plasma membrane to the cytosol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	solute carrier family 6 member 3	Homo sapiens	65-69
11978812-7	2002	Last, a voltage-dependent calcium channel-dependent form of LTP in the CA1 could also be reversibly abated by LY294002, raising the possibility that PI3-kinase could be required for the expression of multiple forms of synaptic potentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	carbonic anhydrase 1	Rattus norvegicus	71-74
12065645-7	2002	The LY294002-induced reduction in [(3)H]DA uptake and hDAT cell surface expression was inhibited by expression of a dominant negative mutant of dynamin I, indicating that dynamin-dependent trafficking can modulate transport capacity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	4-12	solute carrier family 6 member 3	Homo sapiens	54-58
12054565-7	2002	PD098059 and U0126, two MAPK kinase inhibitors, and LY294002, a PI3K inhibitor, significantly blocked thrombin-induced [(3)H]thymidine incorporation and cyclin D(1) expression in ASM cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	G1/S-specific cyclin-D1	Cavia porcellus	153-164
11842081-3	2002	We found that LY294002, a PI3K inhibitor, blocked the effects of serum to prevent Bax translocation to mitochondria and that expression of an active form of PI3K suppressed staurosporine-induced Bax translocation, suggesting that PI3K activity is essential for retaining Bax in the cytoplasm.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	BCL2 associated X, apoptosis regulator	Homo sapiens	82-85
11965537-5	2002	In addition, the cytokine-induced Rac activation was inhibited by a phosphatidyl-inositol 3"-kinase (PI3K) inhibitor, LY294002, which also inhibited the Erk activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	AKT serine/threonine kinase 1	Homo sapiens	34-37
11965537-5	2002	In addition, the cytokine-induced Rac activation was inhibited by a phosphatidyl-inositol 3"-kinase (PI3K) inhibitor, LY294002, which also inhibited the Erk activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	68-99
11965537-5	2002	In addition, the cytokine-induced Rac activation was inhibited by a phosphatidyl-inositol 3"-kinase (PI3K) inhibitor, LY294002, which also inhibited the Erk activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	mitogen-activated protein kinase 1	Homo sapiens	153-156
11929788-8	2002	Inhibition of PI3-kinase by LY294002 induced apoptosis of B-CLL cells and inhibited the survival effect of IL-4 and TPA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	interleukin 4	Homo sapiens	107-111
11931654-11	2002	In addition, inhibition of PI-3K with wortmannin and LY294002 blocked beta1 integrin-mediated NF-kappaB activation, but did not affect that mediated by beta2 integrin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	70-75
11931654-11	2002	In addition, inhibition of PI-3K with wortmannin and LY294002 blocked beta1 integrin-mediated NF-kappaB activation, but did not affect that mediated by beta2 integrin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	nuclear factor kappa B subunit 1	Homo sapiens	94-103
11948662-5	2002	The PI3-kinase antagonist LY294002 (100 nmol/eye) reduced the retrograde axonal transport of (125)I-NT-4 in sympathetic and sensory neurons, and (125)I-NT-3 in sympathetic neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	neurotrophin 3	Homo sapiens	152-156
11809767-3	2002	Inhibition of 1-phosphatidylinositol 3-kinase by LY294002 blocks insulin-induced sequestration of the beta(2)-adrenergic receptor, implicating Akt in downstream signaling to the beta(2)-adrenergic receptor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	insulin	Homo sapiens	65-72
11948662-5	2002	The PI3-kinase antagonist LY294002 (100 nmol/eye) reduced the retrograde axonal transport of (125)I-NT-4 in sympathetic and sensory neurons, and (125)I-NT-3 in sympathetic neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	neurotrophin 4	Homo sapiens	100-104
11950883-4	2002	The increase of telomerase activity by Kitl is blocked by the presence of the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	kit ligand	Mus musculus	39-43
11842081-3	2002	We found that LY294002, a PI3K inhibitor, blocked the effects of serum to prevent Bax translocation to mitochondria and that expression of an active form of PI3K suppressed staurosporine-induced Bax translocation, suggesting that PI3K activity is essential for retaining Bax in the cytoplasm.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	BCL2 associated X, apoptosis regulator	Homo sapiens	195-198
11842081-3	2002	We found that LY294002, a PI3K inhibitor, blocked the effects of serum to prevent Bax translocation to mitochondria and that expression of an active form of PI3K suppressed staurosporine-induced Bax translocation, suggesting that PI3K activity is essential for retaining Bax in the cytoplasm.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	BCL2 associated X, apoptosis regulator	Homo sapiens	195-198
12064484-6	2002	Neuroprotection against NMDA or QUIN by SF/HGF and FGF-1 was negated by the addition of LY294002 (10 microM) or wortmannin (100 microM), two distinct inhibitors of phosphatidylinositol 3-kinase (P13-K), but not by the MAP-kinase kinase (MEK) inhibitor PD98059 (33 microm).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	hepatocyte growth factor	Homo sapiens	40-46
11815622-6	2002	The inhibition of PI3K enzymatic activity with either wortmannin or LY294002 prior to 2B4 ligation does not alter the association of 2B4 with the p85 subunit but prevents the recruitment of SAP/SH2D1A to 2B4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	SH2 domain containing 1A	Homo sapiens	190-200
11809761-6	2002	The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 fully inhibited contraction-stimulated Akt phosphorylation and activity but did not diminish contraction-stimulated glycogen synthase kinase-3 phosphorylation and glycogen synthase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Rattus norvegicus	108-111
11809761-7	2002	These results demonstrate that contraction increases Akt phosphorylation and activity in skeletal muscle and that this stimulation is rapid, transient, muscle fiber type-specific, and wortmannin- and LY294002-inhibitable.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	AKT serine/threonine kinase 1	Rattus norvegicus	53-56
11934809-10	2002	Incubation of rat aortic rings up to 6 h with LY 294002 (25 microM), a specific inhibitor of PI(3)K akt/pkb pathway reduced E2-induced vasorelaxation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-55	AKT serine/threonine kinase 1	Rattus norvegicus	100-103
11991736-6	2002	In addition, chemical inhibitors of the PI-3 kinase pathway, wortmannin and LY294002 inhibit Ucn mediated cardioprotection in HR in both neonatal and adult cardiac myocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	urocortin	Rattus norvegicus	93-96
12064484-6	2002	Neuroprotection against NMDA or QUIN by SF/HGF and FGF-1 was negated by the addition of LY294002 (10 microM) or wortmannin (100 microM), two distinct inhibitors of phosphatidylinositol 3-kinase (P13-K), but not by the MAP-kinase kinase (MEK) inhibitor PD98059 (33 microm).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	fibroblast growth factor 1	Homo sapiens	51-56
11880313-8	2002	LY-294002 also abrogated ELT3 cell migration stimulated by bFGF and TGF-alpha but not by VEGF and phorbol 12-myristate 13-acetate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	fibroblast growth factor 2	Rattus norvegicus	59-63
11880313-8	2002	LY-294002 also abrogated ELT3 cell migration stimulated by bFGF and TGF-alpha but not by VEGF and phorbol 12-myristate 13-acetate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	transforming growth factor alpha	Rattus norvegicus	68-77
11961297-7	2002	LY294002 was found to attenuate VEGF-stimulated eNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	vascular endothelial growth factor A	Homo sapiens	32-36
11961297-7	2002	LY294002 was found to attenuate VEGF-stimulated eNOS expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 3	Homo sapiens	48-52
11918738-8	2002	Blocking PI3-kinase with LY294002 reduced Akt activation and abrogated the anti-apoptotic effect of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	thymoma viral proto-oncogene 1	Mus musculus	42-45
11989975-4	2002	However, in the HT-29 cells pre-treated with PI3K inhibitor, LY294002, zinc induced further the p21(CiP/WAF) induction whereas abrogated cyclin D1 induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	cyclin dependent kinase inhibitor 1A	Homo sapiens	96-99
11799110-3	2002	In contrast, inhibiting the phosphatidylinositol 3-kinase (PI3K) pathway with the drug LY294002, a dominant negative mutant of PI3K, Deltap85, or the phosphatidylinositol phosphatase PTEN (phosphatase and tensin homologue deleted in chromosome ten) resulted in a dramatic reduction of v-Ros- and epidermal growth factor receptor-Ros-promoted anchorage-independent growth of chicken embryo fibroblasts and NIH3T3 cells, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	28-57
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	signal transducer and activator of transcription 3	Mus musculus	72-77
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	signal transducer and activator of transcription 3	Mus musculus	79-85
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	signal transducer and activator of transcription 3	Mus musculus	79-84
11989975-4	2002	However, in the HT-29 cells pre-treated with PI3K inhibitor, LY294002, zinc induced further the p21(CiP/WAF) induction whereas abrogated cyclin D1 induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	adenylate kinase 6	Homo sapiens	100-103
11989975-4	2002	However, in the HT-29 cells pre-treated with PI3K inhibitor, LY294002, zinc induced further the p21(CiP/WAF) induction whereas abrogated cyclin D1 induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	cyclin D1	Homo sapiens	137-146
11779850-3	2002	The PI3K inhibitors Ly294002 and wortmannin reduced p21(Cip1) protein abundance in human umbilical vein EC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	52-55
11943209-3	2002	Pretreatment of human melanoma cell line A2058 with wortmannin or LY294002 inhibited ATX-induced motility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	85-88
11779850-3	2002	The PI3K inhibitors Ly294002 and wortmannin reduced p21(Cip1) protein abundance in human umbilical vein EC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	56-60
11781306-3	2002	Pretreatment of SHIP -/- cells with 25 microm LY294002 resulted in complete inhibition of SF-induced PI(3,4)P(2), while still yielding PI(3,4,5)P(3) levels similar to those achieved in SHIP+/+ cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	inositol polyphosphate-5-phosphatase D	Mus musculus	16-20
11904450-5	2002	Phosphorylation is diminished by wortmannin and LY294002, inhibitors of PI3-kinase, the upstream activator of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	thymoma viral proto-oncogene 1	Mus musculus	110-113
11781306-3	2002	Pretreatment of SHIP -/- cells with 25 microm LY294002 resulted in complete inhibition of SF-induced PI(3,4)P(2), while still yielding PI(3,4,5)P(3) levels similar to those achieved in SHIP+/+ cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	kit ligand	Mus musculus	90-92
11781306-3	2002	Pretreatment of SHIP -/- cells with 25 microm LY294002 resulted in complete inhibition of SF-induced PI(3,4)P(2), while still yielding PI(3,4,5)P(3) levels similar to those achieved in SHIP+/+ cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	inositol polyphosphate-5-phosphatase D	Mus musculus	185-189
11781306-7	2002	Moreover, intracellular delivery of PI(3,4)P(2) to LY294002-pretreated, SF-stimulated SHIP -/- cells increased phosphorylation of PKB at Ser-473 and increased PKB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	kit ligand	Mus musculus	72-74
11781306-7	2002	Moreover, intracellular delivery of PI(3,4)P(2) to LY294002-pretreated, SF-stimulated SHIP -/- cells increased phosphorylation of PKB at Ser-473 and increased PKB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	inositol polyphosphate-5-phosphatase D	Mus musculus	86-90
11781306-7	2002	Moreover, intracellular delivery of PI(3,4)P(2) to LY294002-pretreated, SF-stimulated SHIP -/- cells increased phosphorylation of PKB at Ser-473 and increased PKB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	thymoma viral proto-oncogene 2	Mus musculus	130-133
11781306-7	2002	Moreover, intracellular delivery of PI(3,4)P(2) to LY294002-pretreated, SF-stimulated SHIP -/- cells increased phosphorylation of PKB at Ser-473 and increased PKB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	thymoma viral proto-oncogene 2	Mus musculus	159-162
11756417-7	2002	AG490, a specific inhibitor for Jak2, and LY294002, a specific inhibitor for phosphatidylinositol (PI) 3-kinase, reduced the protein level of Bcl-xL in UT-7/TPO cells, accompanied by an increase in the ratio of apoptotic cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	BCL2 like 1	Homo sapiens	142-148
11756417-9	2002	Concomitantly, confocal microscopy revealed that LY294002 clearly inhibited the nuclear export of Stat5, suggesting that PI 3-kinase regulates the subcellular localization of Stat5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	signal transducer and activator of transcription 5A	Homo sapiens	98-103
11756417-7	2002	AG490, a specific inhibitor for Jak2, and LY294002, a specific inhibitor for phosphatidylinositol (PI) 3-kinase, reduced the protein level of Bcl-xL in UT-7/TPO cells, accompanied by an increase in the ratio of apoptotic cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	thrombopoietin	Homo sapiens	157-160
11756417-9	2002	Concomitantly, confocal microscopy revealed that LY294002 clearly inhibited the nuclear export of Stat5, suggesting that PI 3-kinase regulates the subcellular localization of Stat5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	peptidase inhibitor 3	Homo sapiens	121-125
11756417-8	2002	Interestingly, LY294002 enhanced the TPO-induced DNA binding activity of Stat5 without affecting the Jak2 activation and tyrosine phosphorylation of Stat5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	thrombopoietin	Homo sapiens	37-40
11756417-9	2002	Concomitantly, confocal microscopy revealed that LY294002 clearly inhibited the nuclear export of Stat5, suggesting that PI 3-kinase regulates the subcellular localization of Stat5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	signal transducer and activator of transcription 5A	Homo sapiens	175-180
11756417-8	2002	Interestingly, LY294002 enhanced the TPO-induced DNA binding activity of Stat5 without affecting the Jak2 activation and tyrosine phosphorylation of Stat5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	signal transducer and activator of transcription 5A	Homo sapiens	73-78
11861293-9	2002	To study the mechanism of cell cycle arrest by LY294002, the activity of the cdk4 complex, which regulates the transit of cells from the G1 to S phase in hematopoietic cells, was examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	cyclin-dependent kinase 4	Mus musculus	77-81
11861293-10	2002	Both STI571 and LY294002 lead to a decrease in the activity of cdk4 kinase activity and a decrease in expression of both Cyclin D2 and Cyclin E within several hours.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	cyclin-dependent kinase 4	Mus musculus	63-67
11861293-10	2002	Both STI571 and LY294002 lead to a decrease in the activity of cdk4 kinase activity and a decrease in expression of both Cyclin D2 and Cyclin E within several hours.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	cyclin D2	Mus musculus	121-130
11953455-7	2002	Moreover, survival assays with the PtdIns3 kinase inhibitor LY294002, active and dominant-negative forms of Akt indicate that the phosphorylation of FKHRL1 plays a role in neurotrophins-mediated cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	forkhead box O3	Rattus norvegicus	149-155
11966759-8	2002	PI3K inhibitors Wortmannin and LY294002 also partially inhibited the MCP-induced chemotaxis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	capping actin protein, gelsolin like	Homo sapiens	69-72
11861503-4	2002	LY294002, a pharmacological inhibitor of PI3K, and the immunosuppressant rapamycin inhibited insulin-induced differentiation of C2C12 myoblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin	Homo sapiens	93-100
11846482-8	2002	This increase in PI3K activity is essential for regulating the GDNF response, since the specific inhibitor, LY294002, blocks migration and chemotaxis of MDCK cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	glial cell derived neurotrophic factor	Canis lupus familiaris	63-67
11850823-6	2002	Suppression of PI3-K and Akt by specific inhibitors LY294002 and Wortmannin reversed TC21-induced transformation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	thymoma viral proto-oncogene 1	Mus musculus	25-28
11861377-7	2002	Furthermore, a phosphatidylinositol 3-kinase inhibitor, LY-294002, was found to mimic the different actions of nobiletin on the production of proMMP-9 and TIMP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-65	TIMP metallopeptidase inhibitor 1	Homo sapiens	155-161
11850846-7	2002	Treatment of LCL with LY294002 causes a reduction of the expression of both cyclin D2 and cyclin D3, two key cyclins required for cell cycle progression but does not affect the expression of the EBV latent genes, EBNA2A or LMP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	proliferating cell nuclear antigen	Homo sapiens	76-82
11850846-7	2002	Treatment of LCL with LY294002 causes a reduction of the expression of both cyclin D2 and cyclin D3, two key cyclins required for cell cycle progression but does not affect the expression of the EBV latent genes, EBNA2A or LMP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	proliferating cell nuclear antigen	Homo sapiens	90-96
11850846-7	2002	Treatment of LCL with LY294002 causes a reduction of the expression of both cyclin D2 and cyclin D3, two key cyclins required for cell cycle progression but does not affect the expression of the EBV latent genes, EBNA2A or LMP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	LMP1	Human gammaherpesvirus 4	223-228
11850846-8	2002	LY294002 also causes an increase in p27kip1, a cyclin dependent kinase inhibitor and results in the dephosphorylation of members of the pocket protein family.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	36-43
11850846-8	2002	LY294002 also causes an increase in p27kip1, a cyclin dependent kinase inhibitor and results in the dephosphorylation of members of the pocket protein family.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	proliferating cell nuclear antigen	Homo sapiens	47-53
11850817-5	2002	HGF/SF-mediated phosphorylation of ATF-2 was reduced in the presence of either the p38 kinase-specific inhibitor SB203580, a dominant negative p38 mutant, the SAPK/JNK inhibitor JNK-interacting protein-1 (JIP-1), or the phosphatidylinositol 3-kinase (PI3K)-specific inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	276-284	hepatocyte growth factor	Mus musculus	0-6
11850817-5	2002	HGF/SF-mediated phosphorylation of ATF-2 was reduced in the presence of either the p38 kinase-specific inhibitor SB203580, a dominant negative p38 mutant, the SAPK/JNK inhibitor JNK-interacting protein-1 (JIP-1), or the phosphatidylinositol 3-kinase (PI3K)-specific inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	276-284	activating transcription factor 2	Mus musculus	35-40
11733515-4	2002	Conversely, inhibition of PI3K-AKT signaling via the specific pharmacological inhibitor LY294002 up-regulated AP1/Jun- and STAT-dependent transcriptional activities, resulting in suppression of the FasR promoter activities and decreased FasR surface expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Homo sapiens	31-34
11733515-4	2002	Conversely, inhibition of PI3K-AKT signaling via the specific pharmacological inhibitor LY294002 up-regulated AP1/Jun- and STAT-dependent transcriptional activities, resulting in suppression of the FasR promoter activities and decreased FasR surface expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-113
11726672-8	2002	As expected, CDC42 and Rac1 activation mediated by EGLT can be completely inhibited by PI3K inhibitors, wortmannin and LY294002, and the p85 dominant negative mutant but not by either the phospholipase C inhibitor, or an intracellular Ca(2+) chilator BAPTA/AM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	cell division cycle 42	Homo sapiens	13-18
11726672-8	2002	As expected, CDC42 and Rac1 activation mediated by EGLT can be completely inhibited by PI3K inhibitors, wortmannin and LY294002, and the p85 dominant negative mutant but not by either the phospholipase C inhibitor, or an intracellular Ca(2+) chilator BAPTA/AM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	Rac family small GTPase 1	Homo sapiens	23-27
11850823-6	2002	Suppression of PI3-K and Akt by specific inhibitors LY294002 and Wortmannin reversed TC21-induced transformation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	related RAS viral (r-ras) oncogene 2	Mus musculus	85-89
11850823-9	2002	Treatment of PI3-K inhibitor LY294002 significantly suppressed TC21-mediated NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	related RAS viral (r-ras) oncogene 2	Mus musculus	63-67
11850823-9	2002	Treatment of PI3-K inhibitor LY294002 significantly suppressed TC21-mediated NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-86
11773707-0	2002	Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	BCL2, apoptosis regulator	Rattus norvegicus	55-60
11804874-5	2002	Moreover, these stimuli appeared to induce the serine and threonine phosphorylation of Akt, which was reduced by the PI 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Homo sapiens	87-90
11804874-7	2002	Treatment of monocytes with either LY294002 or wortmannin resulted in caspase-3 activation in the presence of these survival factors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	caspase 3	Homo sapiens	70-79
11773707-0	2002	Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	BCL2, apoptosis regulator	Rattus norvegicus	116-121
11804875-7	2002	In addition, LY294002, which is the specific inhibitor of phosphatidyl inositol 3-kinase, partially inhibited HGF- and serum-stimulated proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	hepatocyte growth factor	Homo sapiens	110-113
11773707-7	2002	Interestingly, we also found that LY294002 treatment increased bcl-2 protein levels in normal rat kidney epithelial cells expressing bcl-2 (NRK-bcl-2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	BCL2, apoptosis regulator	Rattus norvegicus	63-68
11773707-7	2002	Interestingly, we also found that LY294002 treatment increased bcl-2 protein levels in normal rat kidney epithelial cells expressing bcl-2 (NRK-bcl-2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	BCL2, apoptosis regulator	Rattus norvegicus	133-138
11773707-7	2002	Interestingly, we also found that LY294002 treatment increased bcl-2 protein levels in normal rat kidney epithelial cells expressing bcl-2 (NRK-bcl-2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	BCL2, apoptosis regulator	Rattus norvegicus	133-138
11773707-9	2002	In OKA treated cells that were pre-treated with Ly294002, bcl-2 was highly co-localized with mitochondria, but in cells treated with okadaic acid alone, bcl-2 was associated with fragmented chromatin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	BCL2, apoptosis regulator	Rattus norvegicus	58-63
11773707-10	2002	In this model, it appears that LY294002 may exert anti-apoptotic effects by a previously unreported treatment related increase in bcl-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	BCL2, apoptosis regulator	Rattus norvegicus	130-135
11815457-10	2002	LY294002 (25 micromol/l) significantly reduced the effect of the insulin mimetic on beta-cell exocytosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin	Cricetulus griseus	65-72
11830512-3	2002	Using LNCaP prostate cancer cells as an experimental paradigm of FAS-overexpressing PTEN-null cancer cells, we demonstrate that LY294002, an inhibitor of the PI3k pathway causes a dramatic decrease in FAS protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	fatty acid synthase	Homo sapiens	65-68
11830512-3	2002	Using LNCaP prostate cancer cells as an experimental paradigm of FAS-overexpressing PTEN-null cancer cells, we demonstrate that LY294002, an inhibitor of the PI3k pathway causes a dramatic decrease in FAS protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	phosphatase and tensin homolog	Homo sapiens	84-88
11830512-3	2002	Using LNCaP prostate cancer cells as an experimental paradigm of FAS-overexpressing PTEN-null cancer cells, we demonstrate that LY294002, an inhibitor of the PI3k pathway causes a dramatic decrease in FAS protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	fatty acid synthase	Homo sapiens	201-204
11828365-8	2002	IL-2 mediated rescue of T cells from apoptosis but no induction of proliferation occurred in thepresence of LY294002, an inhibitor of PI3 K, which also blocked subsequent PKB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	interleukin 2	Homo sapiens	0-4
11796489-8	2002	Interestingly, the PI3K inhibitors wortmannin and LY294002 blocked insulin-stimulated class I PI3K-dependent events at much lower doses than that required to inhibit phosphorylation of IkappaBalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	insulin	Homo sapiens	67-74
11796489-8	2002	Interestingly, the PI3K inhibitors wortmannin and LY294002 blocked insulin-stimulated class I PI3K-dependent events at much lower doses than that required to inhibit phosphorylation of IkappaBalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	NFKB inhibitor alpha	Homo sapiens	185-197
11796494-6	2002	IGF-I acutely stimulated Akt phosphorylation, which was abolished by pretreatment of cells with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	insulin like growth factor 1	Homo sapiens	0-5
11796494-7	2002	Pretreatment of the cells with LY294002 also greatly attenuated IGF-I induction of HIF-2alpha and blunted IGF-I-induced VEGF promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	insulin like growth factor 1	Homo sapiens	64-69
11796494-7	2002	Pretreatment of the cells with LY294002 also greatly attenuated IGF-I induction of HIF-2alpha and blunted IGF-I-induced VEGF promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	endothelial PAS domain protein 1	Homo sapiens	83-93
11796494-7	2002	Pretreatment of the cells with LY294002 also greatly attenuated IGF-I induction of HIF-2alpha and blunted IGF-I-induced VEGF promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	insulin like growth factor 1	Homo sapiens	106-111
11796494-7	2002	Pretreatment of the cells with LY294002 also greatly attenuated IGF-I induction of HIF-2alpha and blunted IGF-I-induced VEGF promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	vascular endothelial growth factor A	Homo sapiens	120-124
11828365-8	2002	IL-2 mediated rescue of T cells from apoptosis but no induction of proliferation occurred in thepresence of LY294002, an inhibitor of PI3 K, which also blocked subsequent PKB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	AKT serine/threonine kinase 1	Homo sapiens	171-174
11882602-11	2002	By contrast, LY294002 inhibited HB-EGF-induced Akt and p70S6K activation without effecting ERK activation by HB-EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	heparin-binding EGF-like growth factor	Rattus norvegicus	32-38
11882602-11	2002	By contrast, LY294002 inhibited HB-EGF-induced Akt and p70S6K activation without effecting ERK activation by HB-EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	47-50
11882602-11	2002	By contrast, LY294002 inhibited HB-EGF-induced Akt and p70S6K activation without effecting ERK activation by HB-EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	ribosomal protein S6 kinase B1	Rattus norvegicus	55-61
11818455-9	2002	Pretreatment of the cells with LY294002, GF109203X, and Go 6976 but not PD98059 blocked WKYMVm-induced monocyte survival and caspase-3 inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	caspase 3	Homo sapiens	125-134
11801244-0	2002	Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	mitogen activated protein kinase 3	Rattus norvegicus	45-51
12503617-4	2002	Both, IL-4 and IGF-1, signaling pathways induced phosphorylation of Akt kinase in a PI 3-kinase-dependent manner, as assessed by addition of the PI 3-kinase inhibitor Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	interleukin 4	Homo sapiens	6-10
12503617-4	2002	Both, IL-4 and IGF-1, signaling pathways induced phosphorylation of Akt kinase in a PI 3-kinase-dependent manner, as assessed by addition of the PI 3-kinase inhibitor Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	insulin like growth factor 1	Homo sapiens	15-20
12503617-4	2002	Both, IL-4 and IGF-1, signaling pathways induced phosphorylation of Akt kinase in a PI 3-kinase-dependent manner, as assessed by addition of the PI 3-kinase inhibitor Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	AKT serine/threonine kinase 1	Homo sapiens	68-71
12503617-4	2002	Both, IL-4 and IGF-1, signaling pathways induced phosphorylation of Akt kinase in a PI 3-kinase-dependent manner, as assessed by addition of the PI 3-kinase inhibitor Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	peptidase inhibitor 3	Homo sapiens	84-88
12503617-4	2002	Both, IL-4 and IGF-1, signaling pathways induced phosphorylation of Akt kinase in a PI 3-kinase-dependent manner, as assessed by addition of the PI 3-kinase inhibitor Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	peptidase inhibitor 3	Homo sapiens	145-149
11818505-7	2002	The inhibitory effect of IGF-I on the NIS promoter was blocked by the PI3K inhibitor LY294002 and was mimicked by overexpression of a vector harboring the constitutively activated catalytic subunit of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	insulin-like growth factor 1	Rattus norvegicus	25-30
11907830-6	2002	The effect of IGF-1 on K+ current was blocked by inhibitors of phosphatidylinositol 3-kinase (PI3-kinase), wortmannin and LY294002, and mimicked by overexpression of human 3-phosphoinositide-dependent protein kinase-1 (hPDK1) or serum- and glucocorticoid-dependent kinase-1 (hSGK1), both sequential downstream targets of PI3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	insulin like growth factor 1	Homo sapiens	14-19
11707464-4	2002	The inhibitory action of insulin on SEK1 or JNK1 activation was prevented by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	insulin	Homo sapiens	25-32
11707464-4	2002	The inhibitory action of insulin on SEK1 or JNK1 activation was prevented by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	mitogen-activated protein kinase kinase 4	Homo sapiens	36-40
11707464-4	2002	The inhibitory action of insulin on SEK1 or JNK1 activation was prevented by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	mitogen-activated protein kinase 8	Homo sapiens	44-48
11801244-2	2002	Pre-treatment with apigenin or LY294002 sustained EGF-stimulated ERK1/2 phosphorylation whereas wortmannin partially blocked initial ERK1/2 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	mitogen activated protein kinase 3	Rattus norvegicus	65-71
11801244-4	2002	Wortmannin, LY294002 and apigenin totally blocked growth factor-induced protein kinase B phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	myotrophin	Rattus norvegicus	50-63
11687577-7	2002	Further evidence for the central role of a pathway involving PI 3-K and AKT in preserving cell viability during RSV infection was established by the observation that constitutively active AKT transfected into A549 cells prevented the cytotoxicity and apoptosis of combined RSV and LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	281-289	AKT serine/threonine kinase 1	Homo sapiens	72-75
11687577-7	2002	Further evidence for the central role of a pathway involving PI 3-K and AKT in preserving cell viability during RSV infection was established by the observation that constitutively active AKT transfected into A549 cells prevented the cytotoxicity and apoptosis of combined RSV and LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	281-289	AKT serine/threonine kinase 1	Homo sapiens	188-191
11788469-6	2002	S1P stimulated EC migration and tube formation on Matrigel, which processes were significantly decreased by inhibition of activities of PI3K, Akt, or eNOS, whereas treatment with LY294002, a PI3K inhibitor, but not L-NAME, inhibited EC viability and proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
12362981-4	2002	The induction of leukemia cell differentiation in response to the analogs of vitamin D was inhibited by LY294002 (phosphatidylinositol 3-kinase inhibitor), PD98059 (inhibitor of MEK1,2, an upstream regulator of extracellular-signal regulated kinase) and rapamycin (p70S6K inhibitor) pointing out that activation of signal transduction pathways unrelated to nVDR is necessary for differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	ribosomal protein S6 kinase B1	Homo sapiens	265-271
12373512-5	2002	Akt phosphorylation was completely blocked by the PI-3 kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 1	Homo sapiens	0-3
11822409-3	2002	TNFalpha production was measured in supernatants from these cocultures following blockade of the transcription factor nuclear factor kappaB (NF-kappaB) using adenoviral transfer of the inhibitor of NF-kappaB kinase alpha into the responding monocytes, or blockade of phosphatidylinositol 3-kinase (PI 3-kinase) using the inhibitory drugs wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	352-360	tumor necrosis factor	Homo sapiens	0-8
11879539-7	2002	PI3K involvement was also shown by phosphorylation of the downstream effector protein kinase B. Spontaneous IL-10 production by RA-SMCs was also inhibited by LY294002 and depletion of the nonadherent (T-cell-enriched) fraction of the cell population.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	interleukin 10	Homo sapiens	108-113
12046690-0	2002	Degradation of IkappaBalpha in activated RAW264.7 cells is blocked by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	15-27
11756165-6	2002	Under static conditions, inhibiting PI 3-kinase with LY294002 or wortmannin did not prevent platelet adhesion, integrin alpha(IIb)beta(3) activation, or platelet spreading although it significantly delayed the onset of these events.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	peptidase inhibitor 3	Homo sapiens	36-40
12046690-5	2002	Pretreatment of the cells with LY294002 resulted in the inhibition of TNF-alpha and IL-6 production in RAW264.7 cells stimulated with IFN-gamma plus LPS or IFN-gamma plus PMA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	tumor necrosis factor	Mus musculus	70-79
12377207-6	2002	VEGF induced phosphorylation of PKC delta at Thr 505 in the activation loop, and this phosphorylation was inhibited by LY294002, suggesting that modulation of PKC delta activation by VEGF occurs distal to phosphatidylinositol 3"-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	vascular endothelial growth factor A	Homo sapiens	0-4
12046690-5	2002	Pretreatment of the cells with LY294002 resulted in the inhibition of TNF-alpha and IL-6 production in RAW264.7 cells stimulated with IFN-gamma plus LPS or IFN-gamma plus PMA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	interleukin 6	Mus musculus	84-88
12377207-6	2002	VEGF induced phosphorylation of PKC delta at Thr 505 in the activation loop, and this phosphorylation was inhibited by LY294002, suggesting that modulation of PKC delta activation by VEGF occurs distal to phosphatidylinositol 3"-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	protein kinase C delta	Homo sapiens	32-41
12046690-5	2002	Pretreatment of the cells with LY294002 resulted in the inhibition of TNF-alpha and IL-6 production in RAW264.7 cells stimulated with IFN-gamma plus LPS or IFN-gamma plus PMA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	interferon gamma	Mus musculus	134-143
12377207-6	2002	VEGF induced phosphorylation of PKC delta at Thr 505 in the activation loop, and this phosphorylation was inhibited by LY294002, suggesting that modulation of PKC delta activation by VEGF occurs distal to phosphatidylinositol 3"-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	protein kinase C delta	Homo sapiens	159-168
12046690-6	2002	Furthermore, LY294002 inhibited the production of nitric oxide (NO) in RAW264.7 cells stimulated with IFN-gamma plus LPS or IFN-gamma plus PMA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	interferon gamma	Mus musculus	102-111
12377207-6	2002	VEGF induced phosphorylation of PKC delta at Thr 505 in the activation loop, and this phosphorylation was inhibited by LY294002, suggesting that modulation of PKC delta activation by VEGF occurs distal to phosphatidylinositol 3"-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	vascular endothelial growth factor A	Homo sapiens	183-187
12046690-7	2002	LY294002 also inhibited inducible NO synthase (iNOS) mRNA expression in the activated RAW264.7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 2, inducible	Mus musculus	24-45
12046690-7	2002	LY294002 also inhibited inducible NO synthase (iNOS) mRNA expression in the activated RAW264.7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nitric oxide synthase 2, inducible	Mus musculus	47-51
12046690-8	2002	In conclusion, the present results suggest that PI3-kinase is involved in the signal transduction pathway responsible for LPS- or PMA-mediated TNF-alpha and IL-6 production, and that LY294002 inhibits NO generation through blocking the degradation of IkappaBalpha in activated RAW264.7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	interleukin 6	Mus musculus	157-161
12046690-8	2002	In conclusion, the present results suggest that PI3-kinase is involved in the signal transduction pathway responsible for LPS- or PMA-mediated TNF-alpha and IL-6 production, and that LY294002 inhibits NO generation through blocking the degradation of IkappaBalpha in activated RAW264.7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	183-191	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	251-263
11754354-10	2002	The translocation of PKCzeta and the protective effect of NGF were inhibited by the phosphatidylinositol 3 (PI3)-kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	protein kinase C zeta	Homo sapiens	21-28
11756327-5	2002	When PI 3-kinase in wild-type islets was suppressed by wortmannin or LY294002, the secretion was also substantially potentiated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	5-9
11754354-10	2002	The translocation of PKCzeta and the protective effect of NGF were inhibited by the phosphatidylinositol 3 (PI3)-kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	nerve growth factor	Homo sapiens	58-61
11787050-6	2002	Treatment of PI3K inhibitor LY294002 and the MAP kinase inhibitor PD098059, but not p38 inhibitor SB203580, effectively blocks IGF-1-induced upregulation of Pin1, cyclin D1 and RB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	insulin like growth factor 1	Homo sapiens	127-132
12439862-7	2002	The most conspicuous difference between beta-HCH and HRG in MCF-7 foci formation test was their response to 4-hydroxytamoxifen and LY294002, a PI3K inhibitor, i.e., the action of beta-HCH was inhibited by 4-hydroxytamoxifen but stimulated by LY294002, whereas that of heregulin was suppressed by LY294002 but stimulated by 4-hydroxytamoxifen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	histidine rich glycoprotein	Homo sapiens	53-56
12439862-7	2002	The most conspicuous difference between beta-HCH and HRG in MCF-7 foci formation test was their response to 4-hydroxytamoxifen and LY294002, a PI3K inhibitor, i.e., the action of beta-HCH was inhibited by 4-hydroxytamoxifen but stimulated by LY294002, whereas that of heregulin was suppressed by LY294002 but stimulated by 4-hydroxytamoxifen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	histidine rich glycoprotein	Homo sapiens	53-56
12439862-7	2002	The most conspicuous difference between beta-HCH and HRG in MCF-7 foci formation test was their response to 4-hydroxytamoxifen and LY294002, a PI3K inhibitor, i.e., the action of beta-HCH was inhibited by 4-hydroxytamoxifen but stimulated by LY294002, whereas that of heregulin was suppressed by LY294002 but stimulated by 4-hydroxytamoxifen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	histidine rich glycoprotein	Homo sapiens	53-56
11754748-6	2002	Blocking the activation of Akt with LY294002, a specific inhibitor of the Akt up-stream molecule PI 3-kinase, or an with adenoviral vector for a dominant-negative form of Akt prevented the stimulation of osteoclast survival by IL-1alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	27-30
11787050-6	2002	Treatment of PI3K inhibitor LY294002 and the MAP kinase inhibitor PD098059, but not p38 inhibitor SB203580, effectively blocks IGF-1-induced upregulation of Pin1, cyclin D1 and RB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	157-161
11787050-6	2002	Treatment of PI3K inhibitor LY294002 and the MAP kinase inhibitor PD098059, but not p38 inhibitor SB203580, effectively blocks IGF-1-induced upregulation of Pin1, cyclin D1 and RB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin D1	Homo sapiens	163-172
11756483-5	2002	The tyrosine phosphorylation was blocked by addition of the Src family tyrosine kinase inhibitor 4-amino-5-(4-chlorophenyl)-7(t-butyl)pyrazol(3,4-d)pyramide (PP2) and the phosphatidylinositol 3-kinase inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	211-220	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	60-63
11781387-4	2002	Pretreatment of neutrophils with PP1 and with the PI3K inhibitor LY294002 resulted in a strong inhibition of fMLP-induced superoxide production and cytokine-mediated survival but not fMLP-induced migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	formyl peptide receptor 1	Homo sapiens	109-113
11903815-14	2002	The PI3-kinase inhibitor LY294002 also inhibited the activation of Akt by oestrogen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	thymoma viral proto-oncogene 1	Mus musculus	67-70
11902114-4	2002	We now report that NMDA receptor activation of Erk1/2 was also blocked by inhibitors of PI 3-kinase (LY 294002, wortmannin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-110	mitogen-activated protein kinase 3	Homo sapiens	47-53
11902114-9	2002	Glutamate-induced phosphorylation of cAMP response element binding protein (CREB; Ser133) was partially blocked with either PD98059, U0126, LY294002 or wortmannin but was very strongly inhibited on co-application of LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	cAMP responsive element binding protein 1	Homo sapiens	37-74
11902114-9	2002	Glutamate-induced phosphorylation of cAMP response element binding protein (CREB; Ser133) was partially blocked with either PD98059, U0126, LY294002 or wortmannin but was very strongly inhibited on co-application of LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	cAMP responsive element binding protein 1	Homo sapiens	76-80
11902114-9	2002	Glutamate-induced phosphorylation of cAMP response element binding protein (CREB; Ser133) was partially blocked with either PD98059, U0126, LY294002 or wortmannin but was very strongly inhibited on co-application of LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	216-224	cAMP responsive element binding protein 1	Homo sapiens	37-74
11902114-9	2002	Glutamate-induced phosphorylation of cAMP response element binding protein (CREB; Ser133) was partially blocked with either PD98059, U0126, LY294002 or wortmannin but was very strongly inhibited on co-application of LY294002 and PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	216-224	cAMP responsive element binding protein 1	Homo sapiens	76-80
11756553-6	2002	Consistent with these effects on cell survival, expression of nonphosphorylatable eIF2B prevented inhibition of protein synthesis following treatment of cells with the PI 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	eukaryotic translation initiation factor 2B subunit delta	Rattus norvegicus	82-87
11756483-5	2002	The tyrosine phosphorylation was blocked by addition of the Src family tyrosine kinase inhibitor 4-amino-5-(4-chlorophenyl)-7(t-butyl)pyrazol(3,4-d)pyramide (PP2) and the phosphatidylinositol 3-kinase inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	211-220	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	158-161
11598110-7	2001	Interestingly, the H(2)O(2)-induced activation of Akt was entirely mediated by upstream stimulation of PI 3"-kinase activity, since treatment of 3T3-L1 adipocytes with the PI 3"-kinase inhibitors wortmannin or LY294002 completely blocked the subsequent activation of Akt by exogenous H(2)O(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	AKT serine/threonine kinase 1	Homo sapiens	50-53
11675379-7	2001	TNF-alpha treatment increased the phosphorylation of Akt in osteoclasts, which was suppressed by a phosphatidylinositol 3-kinase inhibitor LY294002 and an Src family kinase-selective inhibitor PP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	tumor necrosis factor	Homo sapiens	0-9
11585835-11	2001	Inhibition of the PI3K pathway by LY294002 or wortmannin effectively attenuated the increased level of Mcl-1 induced by COX-2 or PGE(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	103-108
11585835-11	2001	Inhibition of the PI3K pathway by LY294002 or wortmannin effectively attenuated the increased level of Mcl-1 induced by COX-2 or PGE(2).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	120-125
11585835-13	2001	In a similar way, LY294002 inhibited cell survival and Mcl-1 level in PGE(2)-treated CL1.0 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	55-60
11675379-7	2001	TNF-alpha treatment increased the phosphorylation of Akt in osteoclasts, which was suppressed by a phosphatidylinositol 3-kinase inhibitor LY294002 and an Src family kinase-selective inhibitor PP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	AKT serine/threonine kinase 1	Homo sapiens	53-56
11564730-5	2001	LY294002, an inhibitor of phosphoinositide 3-kinase, completely blocked EGF induction of Akt phosphorylation, whereas the MEK1 inhibitor PD98059 and the protein kinase C inhibitor GF109203X had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	epidermal growth factor	Canis lupus familiaris	72-75
11736661-6	2001	The effects of PI3Kgamma-CAAX could be suppressed by pre-incubation of the oocytes with LY294002, PD98059 or roscovitine, inhibitors of PI3K, MEK (MAPK/extracellular-signal-regulated protein kinase kinase) and cdc2/cyclin B kinase, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha L homeolog	Xenopus laevis	15-29
11736661-6	2001	The effects of PI3Kgamma-CAAX could be suppressed by pre-incubation of the oocytes with LY294002, PD98059 or roscovitine, inhibitors of PI3K, MEK (MAPK/extracellular-signal-regulated protein kinase kinase) and cdc2/cyclin B kinase, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	cyclin-dependent kinase 1 L homeolog	Xenopus laevis	210-214
11716532-8	2001	Wortmannin and LY294002, PI3-kinase inhibitors, as well as lovastatin and PD152440, Ras farnesylation inhibitors, and MEK inhibitor PD98059 abolished the insulin repression of ALAS transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	insulin	Homo sapiens	154-161
11590144-6	2001	Furthermore, the downstream effector of PI3K, protein kinase B/AKT, is activated by NRG in the presence of H(2)O(2), and protein kinase B/AKT activation is inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Homo sapiens	63-66
11590144-6	2001	Furthermore, the downstream effector of PI3K, protein kinase B/AKT, is activated by NRG in the presence of H(2)O(2), and protein kinase B/AKT activation is inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Homo sapiens	138-141
11716532-8	2001	Wortmannin and LY294002, PI3-kinase inhibitors, as well as lovastatin and PD152440, Ras farnesylation inhibitors, and MEK inhibitor PD98059 abolished the insulin repression of ALAS transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	5'-aminolevulinate synthase 1	Homo sapiens	176-180
11698260-7	2001	Wortmannin and LY-294002 abolished phosphorylation of Akt, further supporting activation of PI 3-kinase/Akt as a signaling pathway, which mediates hepatocyte protection by LPA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	thymoma viral proto-oncogene 1	Mus musculus	54-57
11698260-7	2001	Wortmannin and LY-294002 abolished phosphorylation of Akt, further supporting activation of PI 3-kinase/Akt as a signaling pathway, which mediates hepatocyte protection by LPA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	thymoma viral proto-oncogene 1	Mus musculus	104-107
11705740-3	2001	The PI3K inhibitor LY-294002 blocks TNF-alpha- and Fas-mediated Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	tumor necrosis factor	Mus musculus	36-45
11705740-3	2001	The PI3K inhibitor LY-294002 blocks TNF-alpha- and Fas-mediated Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	thymoma viral proto-oncogene 1	Mus musculus	64-67
11705740-9	2001	Furthermore, LY-294002 pretreatment blocks TNF-alpha- and Jo2-induced Bcl-xL levels in hepatocytes, with no effect on the phosphorylation levels of Bad.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-22	tumor necrosis factor	Mus musculus	43-52
11705740-9	2001	Furthermore, LY-294002 pretreatment blocks TNF-alpha- and Jo2-induced Bcl-xL levels in hepatocytes, with no effect on the phosphorylation levels of Bad.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-22	BCL2-like 1	Mus musculus	70-76
11740206-9	2001	Phosphorylation of Akt was prevented after focal cerebral ischemia by LY294002, a phosphatidylinositol 3-kinase inhibitor, which facilitated subsequent DNA fragmentation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	thymoma viral proto-oncogene 1	Mus musculus	19-22
11591714-5	2001	Pretreatment with LY294002 restrained UVB-induced phosphorylation of Erks, suggesting that in UVB signaling, the Erk pathway is mediated by PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	mitogen-activated protein kinase 1	Mus musculus	69-73
11591714-5	2001	Pretreatment with LY294002 restrained UVB-induced phosphorylation of Erks, suggesting that in UVB signaling, the Erk pathway is mediated by PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	mitogen-activated protein kinase 1	Mus musculus	69-72
11717712-5	2001	This effect was dose dependent and abolished by 1 microM H89 (an inhibitor of protein kinase A), 1.25 microM chelerythrine chloride (an inhibitor of protein kinase C), 50 microM PD 98059 (an inhibitor of MEK), 25 microM Ly 294002 (an inhibitor of phosphatidylinositol-3 kinase), 30 nM brefeldin A (an inhibitor of polypeptide release), and 10 microM genistein or 1 ng/ml herbimycin (inhibitors of tyrosine kinase enzymes).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-229	mitogen-activated protein kinase kinase 7	Homo sapiens	204-207
11792123-5	2001	The utilization of the inhibitors, wortmannin and LY294002, demonstrated a role for phosphatidylinositol 3-kinase (PI3K) whereas rapamycin demonstrated p70 S6-kinase (p70S6K) involvement in the production of IL-10 by these monocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	84-113
11571285-9	2001	Furthermore, the Ras inhibitor manumycin A, the PI 3-kinase inhibitor LY294002, and an Akt inhibitor all blocked the induction of interleukin-8 by InlB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	48-52
11571285-9	2001	Furthermore, the Ras inhibitor manumycin A, the PI 3-kinase inhibitor LY294002, and an Akt inhibitor all blocked the induction of interleukin-8 by InlB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	chemokine (C-X-C motif) ligand 15	Mus musculus	130-143
11560920-6	2001	This effect of insulin was blocked by the phosphatidylinositol 3-kinase inhibitor LY294002 or by transiently transfected dominant-negative phosphatidylinositol 3-kinase and protein kinase B mutants.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	insulin	Homo sapiens	15-22
11728454-3	2001	The formation of tubular morphogenesis was inhibited by using the PI3-kinase and NF-kappaB antagonists LY294002 and SN50 respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	nuclear factor kappa B subunit 1	Homo sapiens	81-90
11792123-6	2001	The production of TNF-alpha was enhanced by wortmannin and LY294002, suggesting negative regulation by PI3K; however, it was dependent on p70S6K suggesting a PI3K-independent mechanism of p70S6K activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	tumor necrosis factor	Homo sapiens	18-27
11551908-3	2001	BDNF-triggered protein synthesis was inhibited by LY294002, PD98059, and rapamycin, whereas the effect of insulin was unaffected by PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	brain derived neurotrophic factor	Homo sapiens	0-4
11695994-5	2001	ET-1-induced Gab1 tyrosine phosphorylation was also inhibited by LY294002, which inhibits phosphoinositide 3-kinase (PI 3-kinase) enzymes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	endothelin 1	Homo sapiens	0-4
11689163-4	2001	PD98059 (PD, a specific inhibitor of the ERK kinase MEK), drastically inhibited, LY294002 (LY, a specific inhibitor of phosphatidylinositol-3-kinase, PI-3K) partially inhibited, and GF 109203X (GF, a specific inhibitor of protein kinase C) did not inhibit phosphorylation of ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-83	Eph receptor B1	Rattus norvegicus	275-278
11689163-6	2001	BDNF-induced NPY produced and secreted into the medium was inhibited 73% by PD, 52% by LY and not at all by GF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-89	brain-derived neurotrophic factor	Rattus norvegicus	0-4
11689163-4	2001	PD98059 (PD, a specific inhibitor of the ERK kinase MEK), drastically inhibited, LY294002 (LY, a specific inhibitor of phosphatidylinositol-3-kinase, PI-3K) partially inhibited, and GF 109203X (GF, a specific inhibitor of protein kinase C) did not inhibit phosphorylation of ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	Eph receptor B1	Rattus norvegicus	41-44
11689163-4	2001	PD98059 (PD, a specific inhibitor of the ERK kinase MEK), drastically inhibited, LY294002 (LY, a specific inhibitor of phosphatidylinositol-3-kinase, PI-3K) partially inhibited, and GF 109203X (GF, a specific inhibitor of protein kinase C) did not inhibit phosphorylation of ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	Eph receptor B1	Rattus norvegicus	275-278
11689163-6	2001	BDNF-induced NPY produced and secreted into the medium was inhibited 73% by PD, 52% by LY and not at all by GF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-89	neuropeptide Y	Rattus norvegicus	13-16
11695994-5	2001	ET-1-induced Gab1 tyrosine phosphorylation was also inhibited by LY294002, which inhibits phosphoinositide 3-kinase (PI 3-kinase) enzymes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	GRB2 associated binding protein 1	Homo sapiens	13-17
11689163-4	2001	PD98059 (PD, a specific inhibitor of the ERK kinase MEK), drastically inhibited, LY294002 (LY, a specific inhibitor of phosphatidylinositol-3-kinase, PI-3K) partially inhibited, and GF 109203X (GF, a specific inhibitor of protein kinase C) did not inhibit phosphorylation of ERK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-83	Eph receptor B1	Rattus norvegicus	41-44
11687655-8	2001	Furthermore, pretreatment of cells with the PI3-kinase inhibitor LY294002 inhibited the effects of insulin on both Rab5-GTP loading and dynein binding to microtubules.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	insulin	Homo sapiens	99-106
11695998-10	2001	In cultured human myotubes, up-regulation of p85alpha, p55alpha and p50alpha mRNAs by insulin was abolished by LY294002 (10 microM) and by rapamycin (50 nM), suggesting that the PI 3-kinase/protein kinase B/p70 S6 kinase pathway could be involved in the stimulation of grb-1 gene expression by insulin in human muscle cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	45-53
11695998-10	2001	In cultured human myotubes, up-regulation of p85alpha, p55alpha and p50alpha mRNAs by insulin was abolished by LY294002 (10 microM) and by rapamycin (50 nM), suggesting that the PI 3-kinase/protein kinase B/p70 S6 kinase pathway could be involved in the stimulation of grb-1 gene expression by insulin in human muscle cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	insulin	Homo sapiens	86-93
11695998-10	2001	In cultured human myotubes, up-regulation of p85alpha, p55alpha and p50alpha mRNAs by insulin was abolished by LY294002 (10 microM) and by rapamycin (50 nM), suggesting that the PI 3-kinase/protein kinase B/p70 S6 kinase pathway could be involved in the stimulation of grb-1 gene expression by insulin in human muscle cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	protein tyrosine kinase 2 beta	Homo sapiens	190-206
11695998-10	2001	In cultured human myotubes, up-regulation of p85alpha, p55alpha and p50alpha mRNAs by insulin was abolished by LY294002 (10 microM) and by rapamycin (50 nM), suggesting that the PI 3-kinase/protein kinase B/p70 S6 kinase pathway could be involved in the stimulation of grb-1 gene expression by insulin in human muscle cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	269-274
11695998-10	2001	In cultured human myotubes, up-regulation of p85alpha, p55alpha and p50alpha mRNAs by insulin was abolished by LY294002 (10 microM) and by rapamycin (50 nM), suggesting that the PI 3-kinase/protein kinase B/p70 S6 kinase pathway could be involved in the stimulation of grb-1 gene expression by insulin in human muscle cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	insulin	Homo sapiens	294-301
11696015-8	2001	In contrast, the specific PtdIns 3-kinase inhibitor LY294002 induced apoptosis and markedly decreased p125(FAK) expression and increased FAK proteolysis but had little effect on Y861 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	SEC23 interacting protein	Homo sapiens	102-106
11696015-8	2001	In contrast, the specific PtdIns 3-kinase inhibitor LY294002 induced apoptosis and markedly decreased p125(FAK) expression and increased FAK proteolysis but had little effect on Y861 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	protein tyrosine kinase 2	Homo sapiens	107-110
11696015-8	2001	In contrast, the specific PtdIns 3-kinase inhibitor LY294002 induced apoptosis and markedly decreased p125(FAK) expression and increased FAK proteolysis but had little effect on Y861 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	protein tyrosine kinase 2	Homo sapiens	137-140
11753639-9	2001	One transfected PAE cell line with massive overexpression of HGFR demonstrated scattered morphology and increased PI3-kinase activity in association with increased motility, which was partially inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	61-65
11709727-4	2001	Wortmannin, LY294002, and rapamycin at concentrations that did not affect MAPK phosphorylation but substantially inhibited PI3K, Akt, and p70(S6K) significantly suppressed the soft agar growth of tumor cell lines that overexpress ErbB2 but not the growth of tumor lines with low ErbB2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Homo sapiens	129-132
11709727-4	2001	Wortmannin, LY294002, and rapamycin at concentrations that did not affect MAPK phosphorylation but substantially inhibited PI3K, Akt, and p70(S6K) significantly suppressed the soft agar growth of tumor cell lines that overexpress ErbB2 but not the growth of tumor lines with low ErbB2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	ribosomal protein S6 kinase B1	Homo sapiens	138-141
11709727-4	2001	Wortmannin, LY294002, and rapamycin at concentrations that did not affect MAPK phosphorylation but substantially inhibited PI3K, Akt, and p70(S6K) significantly suppressed the soft agar growth of tumor cell lines that overexpress ErbB2 but not the growth of tumor lines with low ErbB2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	erb-b2 receptor tyrosine kinase 2	Homo sapiens	230-235
11709727-4	2001	Wortmannin, LY294002, and rapamycin at concentrations that did not affect MAPK phosphorylation but substantially inhibited PI3K, Akt, and p70(S6K) significantly suppressed the soft agar growth of tumor cell lines that overexpress ErbB2 but not the growth of tumor lines with low ErbB2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	erb-b2 receptor tyrosine kinase 2	Homo sapiens	279-284
11709727-6	2001	Forced expression of ErbB2 in breast cancer lines originally expressing low ErbB2 levels augmented receptor expression and sensitized those lines to LY294002- and rapamycin-mediated inhibition of colony formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-26
11709727-7	2001	Furthermore, treatment with LY294002 resulted in the selective increase of cyclin-dependent kinase inhibitors p21(Cip1) or p27(Kip1) and suppression of cyclin E-associated Cdk2 kinase activity in ErbB2-overexpressing lines, which may account for their hypersensitivity toward inhibitors of the PI3K pathway in anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	H3 histone pseudogene 16	Homo sapiens	110-113
11709727-7	2001	Furthermore, treatment with LY294002 resulted in the selective increase of cyclin-dependent kinase inhibitors p21(Cip1) or p27(Kip1) and suppression of cyclin E-associated Cdk2 kinase activity in ErbB2-overexpressing lines, which may account for their hypersensitivity toward inhibitors of the PI3K pathway in anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	114-118
11709727-7	2001	Furthermore, treatment with LY294002 resulted in the selective increase of cyclin-dependent kinase inhibitors p21(Cip1) or p27(Kip1) and suppression of cyclin E-associated Cdk2 kinase activity in ErbB2-overexpressing lines, which may account for their hypersensitivity toward inhibitors of the PI3K pathway in anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	dynactin subunit 6	Homo sapiens	123-126
11709727-7	2001	Furthermore, treatment with LY294002 resulted in the selective increase of cyclin-dependent kinase inhibitors p21(Cip1) or p27(Kip1) and suppression of cyclin E-associated Cdk2 kinase activity in ErbB2-overexpressing lines, which may account for their hypersensitivity toward inhibitors of the PI3K pathway in anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin dependent kinase inhibitor 1B	Homo sapiens	127-131
11709727-7	2001	Furthermore, treatment with LY294002 resulted in the selective increase of cyclin-dependent kinase inhibitors p21(Cip1) or p27(Kip1) and suppression of cyclin E-associated Cdk2 kinase activity in ErbB2-overexpressing lines, which may account for their hypersensitivity toward inhibitors of the PI3K pathway in anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin dependent kinase 2	Homo sapiens	172-176
11709727-7	2001	Furthermore, treatment with LY294002 resulted in the selective increase of cyclin-dependent kinase inhibitors p21(Cip1) or p27(Kip1) and suppression of cyclin E-associated Cdk2 kinase activity in ErbB2-overexpressing lines, which may account for their hypersensitivity toward inhibitors of the PI3K pathway in anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	196-201
11687610-4	2001	The changes we see are similar to those observed after treatment with LY294002, an inhibitor of phosphatidylinositol 3-OH kinase, fully consistent with the model that PTEN antagonizes phosphatidylinositol 3-OH kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	phosphatase and tensin homolog	Homo sapiens	167-171
11597896-6	2001	Wortmannin, LY-294002, diphenyleneiodonium (DPI), 4-(2-aminoethyl)benzenesulfonyl fluoride, and apocynin also prevented the ET-1-mediated increases in superoxide production and viable cell numbers.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-21	endothelin 1	Homo sapiens	124-128
11767000-4	2001	LY294002 (LY)-mediated inhibition of P13-K activity down-regulated Bcl-2 but not Mcl-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2 apoptosis regulator	Homo sapiens	67-72
11767000-4	2001	LY294002 (LY)-mediated inhibition of P13-K activity down-regulated Bcl-2 but not Mcl-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-2	BCL2 apoptosis regulator	Homo sapiens	67-72
11689445-6	2001	In turn, stimulation of Src activity is abolished in ERalpha-expressing NIH 3T3 fibroblasts by co-transfection of the dominant-negative p85alpha and in MCF-7 cells by the PI3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-27
11689445-6	2001	In turn, stimulation of Src activity is abolished in ERalpha-expressing NIH 3T3 fibroblasts by co-transfection of the dominant-negative p85alpha and in MCF-7 cells by the PI3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-201	estrogen receptor 1	Homo sapiens	53-60
11533055-9	2001	Furthermore, the PI3K inhibitors wortmannin and LY294002 block RhoA activation induced by fMLP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	ras homolog family member A	Homo sapiens	63-67
11533055-9	2001	Furthermore, the PI3K inhibitors wortmannin and LY294002 block RhoA activation induced by fMLP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	formyl peptide receptor 1	Homo sapiens	90-94
11687655-8	2001	Furthermore, pretreatment of cells with the PI3-kinase inhibitor LY294002 inhibited the effects of insulin on both Rab5-GTP loading and dynein binding to microtubules.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	RAB5A, member RAS oncogene family	Homo sapiens	115-119
11703590-12	2001	The impact of enhanced activation of caspases by wortmannin or LY294002 was reflected on accelerated cisplatin-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	caspase 1	Homo sapiens	37-45
11747364-13	2001	The phosphoinositol (3)-kinase inhibitor LY294002 significantly reduced FGF-2-mediated stimulation of endothelial migration similar to the rate of control cultures.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	fibroblast growth factor 2	Bos taurus	72-77
12086898-9	2001	PI3K inhibition significantly enhanced the antiproliferative and proapoptotic effects of TNF-alpha in both cell lines, Ly294002 also blocked TNF-alpha-induced Akt activation but failed to alter cytoplasmic IkappaBalpha degradation or subsequent NF-kappaB nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	tumor necrosis factor	Homo sapiens	89-98
12086898-9	2001	PI3K inhibition significantly enhanced the antiproliferative and proapoptotic effects of TNF-alpha in both cell lines, Ly294002 also blocked TNF-alpha-induced Akt activation but failed to alter cytoplasmic IkappaBalpha degradation or subsequent NF-kappaB nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	tumor necrosis factor	Homo sapiens	141-150
12086898-9	2001	PI3K inhibition significantly enhanced the antiproliferative and proapoptotic effects of TNF-alpha in both cell lines, Ly294002 also blocked TNF-alpha-induced Akt activation but failed to alter cytoplasmic IkappaBalpha degradation or subsequent NF-kappaB nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	AKT serine/threonine kinase 1	Homo sapiens	159-162
12086898-9	2001	PI3K inhibition significantly enhanced the antiproliferative and proapoptotic effects of TNF-alpha in both cell lines, Ly294002 also blocked TNF-alpha-induced Akt activation but failed to alter cytoplasmic IkappaBalpha degradation or subsequent NF-kappaB nuclear translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-127	nuclear factor kappa B subunit 1	Homo sapiens	245-254
12086898-10	2001	NF-kappaB-dependent gene expression, however, was ultimately suppressed by Ly294002, suggesting that PI3k-dependent activation of NF-kappaB is IkappaBalpha independent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	nuclear factor kappa B subunit 1	Homo sapiens	0-9
12086898-10	2001	NF-kappaB-dependent gene expression, however, was ultimately suppressed by Ly294002, suggesting that PI3k-dependent activation of NF-kappaB is IkappaBalpha independent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	nuclear factor kappa B subunit 1	Homo sapiens	130-139
11602680-5	2001	Basal and insulin-modulated NET activities were reduced by the tyrosine kinase inhibitor genistein and the PI3K inhibitors wortmannin and LY-294002, but not by the PKC inhibitor staurosporine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-147	insulin	Homo sapiens	10-17
11746825-6	2001	Furthermore, application of the phosphatidylinositol-3"-OH kinase inhibitor LY294002 specifically induced apoptosis in Cx43-transfected cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	gap junction protein alpha 1	Homo sapiens	119-123
11694593-4	2001	Ly 294002, a phosphatidylinositol 3-kinase (PI 3-K) inhibitor, or expression of dominant/negative Ras (N17) completely blocked C(2)-ceramide- and sphingomyelinase-induced tyrosine phosphorylation of FAK and paxillin and severely decreased stress fiber formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	protein tyrosine kinase 2	Homo sapiens	199-202
11694593-4	2001	Ly 294002, a phosphatidylinositol 3-kinase (PI 3-K) inhibitor, or expression of dominant/negative Ras (N17) completely blocked C(2)-ceramide- and sphingomyelinase-induced tyrosine phosphorylation of FAK and paxillin and severely decreased stress fiber formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	paxillin	Homo sapiens	207-215
11694570-3	2001	TGF beta-induced FKHRL1 phosphorylation and nuclear exclusion were inhibited by LY294002, an inhibitor of phosphatidylinositol-3 kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	transforming growth factor, beta 1	Mus musculus	0-8
11694570-3	2001	TGF beta-induced FKHRL1 phosphorylation and nuclear exclusion were inhibited by LY294002, an inhibitor of phosphatidylinositol-3 kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	forkhead box O3	Mus musculus	17-23
11788791-12	2001	PI-3-kinase inhibitors, Wortmannin and LY294002 inhibited arsenite-induced phosphorylation of AKT and eNOS but had no effect on phosphorylation of p38.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	AKT serine/threonine kinase 1	Homo sapiens	94-97
11585905-5	2001	We showed that specific inhibitors of either pathway (wortmannin, LY-294002, and PD-98059) all suppressed TGF-beta1-induced angiogenesis mainly by compromising cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-75	transforming growth factor, beta 1	Mus musculus	106-115
11682625-13	2001	However, the combination of AG490 and LY294002 largely prevented PRL-induced Stat5b phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	prolactin	Rattus norvegicus	65-68
11682625-13	2001	However, the combination of AG490 and LY294002 largely prevented PRL-induced Stat5b phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	signal transducer and activator of transcription 5B	Rattus norvegicus	77-83
11788791-12	2001	PI-3-kinase inhibitors, Wortmannin and LY294002 inhibited arsenite-induced phosphorylation of AKT and eNOS but had no effect on phosphorylation of p38.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	nitric oxide synthase 3	Homo sapiens	102-106
11704865-8	2001	Inhibition of PI3-K signalling by LY294002 down-regulated cyclin D2 and up-regulated p27(Kip1) expression at both protein and RNA levels, mimicking the effects of BCR-stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	14-17
11704865-8	2001	Inhibition of PI3-K signalling by LY294002 down-regulated cyclin D2 and up-regulated p27(Kip1) expression at both protein and RNA levels, mimicking the effects of BCR-stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	cyclin D2	Mus musculus	58-67
11704865-8	2001	Inhibition of PI3-K signalling by LY294002 down-regulated cyclin D2 and up-regulated p27(Kip1) expression at both protein and RNA levels, mimicking the effects of BCR-stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	cyclin-dependent kinase inhibitor 1B	Mus musculus	85-88
11704865-8	2001	Inhibition of PI3-K signalling by LY294002 down-regulated cyclin D2 and up-regulated p27(Kip1) expression at both protein and RNA levels, mimicking the effects of BCR-stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	cyclin-dependent kinase inhibitor 1B	Mus musculus	89-93
11704865-8	2001	Inhibition of PI3-K signalling by LY294002 down-regulated cyclin D2 and up-regulated p27(Kip1) expression at both protein and RNA levels, mimicking the effects of BCR-stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	BCR activator of RhoGEF and GTPase	Mus musculus	163-166
11602326-6	2001	The LA-induced neuroprotection and Akt increase were attenuated by pre-treatment with the phosphatidylinositol 3-kinase inhibitor, LY294002 (50 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Rattus norvegicus	35-38
11546773-5	2001	Insulin/IGF1-induced ubiquitination and degradation of IRS-2 was blocked by inhibitors of phosphatidylinositol 3-kinase (wortmannin or LY294002) or mTOR (rapamycin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	insulin	Cricetulus griseus	0-7
11461904-8	2001	Down-regulation of constitutively active Akt by phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002, reversed cellular resistance to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	AKT serine/threonine kinase 1	Homo sapiens	41-44
11546773-5	2001	Insulin/IGF1-induced ubiquitination and degradation of IRS-2 was blocked by inhibitors of phosphatidylinositol 3-kinase (wortmannin or LY294002) or mTOR (rapamycin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	insulin-like growth factor 1	Mus musculus	8-12
11546773-5	2001	Insulin/IGF1-induced ubiquitination and degradation of IRS-2 was blocked by inhibitors of phosphatidylinositol 3-kinase (wortmannin or LY294002) or mTOR (rapamycin).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	insulin receptor substrate 2	Mus musculus	55-60
11710832-8	2001	Additionally, we demonstrated that inhibition of the P13K pathway with LY294002 sensitised the MDR-1-expressing 1847/TX0.5 cells and 1847/MDR5 cells at least 10-fold but had no effect in the wild-type cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	ATP binding cassette subfamily B member 1	Homo sapiens	95-100
11483613-6	2001	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 blocked Myc up-regulation in a concentration-dependent manner but had no effect on the Epo-induced phosphorylation of ERK1 and ERK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	68-71
11461904-8	2001	Down-regulation of constitutively active Akt by phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002, reversed cellular resistance to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	TNF superfamily member 10	Homo sapiens	147-152
11483613-11	2001	LY294002 blocked transcription of c-myc at exon 1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	34-39
11591769-9	2001	Wortmannin and LY294002 also totally inhibited activation of extracellular signal-related kinase (ERK)1/2 by IL-10.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mitogen-activated protein kinase 3	Mus musculus	61-105
11500504-6	2001	Induction of myogenin by IGF-I and myotube formation were prevented by the phosphatidylinositol (PI) 3-kinase inhibitor, LY294002, even when included 2 days after growth factor addition, whereas expression of active PI 3-kinase could promote differentiation in the absence of IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	myogenin	Mus musculus	13-21
11500504-6	2001	Induction of myogenin by IGF-I and myotube formation were prevented by the phosphatidylinositol (PI) 3-kinase inhibitor, LY294002, even when included 2 days after growth factor addition, whereas expression of active PI 3-kinase could promote differentiation in the absence of IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	insulin-like growth factor 1	Mus musculus	25-30
11500504-6	2001	Induction of myogenin by IGF-I and myotube formation were prevented by the phosphatidylinositol (PI) 3-kinase inhibitor, LY294002, even when included 2 days after growth factor addition, whereas expression of active PI 3-kinase could promote differentiation in the absence of IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	insulin-like growth factor 1	Mus musculus	276-281
11500504-8	2001	The differentiation-promoting effects of IGF-I were mimicked by a modified membrane-targeted inducible Akt-1 (iAkt), and iAkt was able to stimulate differentiation of C2 myoblasts and primary mouse myoblasts incubated with otherwise inhibitory concentrations of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	262-270	insulin-like growth factor 1	Mus musculus	41-46
11500504-8	2001	The differentiation-promoting effects of IGF-I were mimicked by a modified membrane-targeted inducible Akt-1 (iAkt), and iAkt was able to stimulate differentiation of C2 myoblasts and primary mouse myoblasts incubated with otherwise inhibitory concentrations of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	262-270	thymoma viral proto-oncogene 1	Mus musculus	103-108
11597134-12	2001	The antiapoptotic activity of insulin can be inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	insulin	Homo sapiens	30-37
11591769-9	2001	Wortmannin and LY294002 also totally inhibited activation of extracellular signal-related kinase (ERK)1/2 by IL-10.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 10	Mus musculus	109-114
11571784-11	2001	LY294002 prevented both BAD phosphorylation at Ser 136 and Bcl-x(L) protein induction, while PD098,059 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Bcl2-like 1	Rattus norvegicus	59-67
11597941-1	2001	LY 294002 (80 micromol/L), an inhibitor of phosphoinositide 3-kinase, was used to investigate the involvement of this enzyme in the insulin-mediated regulation of very low density lipoprotein (VLDL) apolipoprotein B (apoB) output from cultured rat hepatocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	apolipoprotein B	Rattus norvegicus	199-215
11597941-1	2001	LY 294002 (80 micromol/L), an inhibitor of phosphoinositide 3-kinase, was used to investigate the involvement of this enzyme in the insulin-mediated regulation of very low density lipoprotein (VLDL) apolipoprotein B (apoB) output from cultured rat hepatocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	apolipoprotein B	Rattus norvegicus	217-221
11597941-10	2001	Furthermore, when insulin remained present during this period, the simultaneous presence of LY 294002 also reversed the inhibitory effect of insulin on VLDL apoB output and abolished the increase in apoB degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-101	apolipoprotein B	Rattus norvegicus	157-161
11597941-10	2001	Furthermore, when insulin remained present during this period, the simultaneous presence of LY 294002 also reversed the inhibitory effect of insulin on VLDL apoB output and abolished the increase in apoB degradation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-101	apolipoprotein B	Rattus norvegicus	199-203
11585776-3	2001	Because hypoxia is a major stimulus for VEGF production, we examined the effects of LY294002, a selective PI3K inhibitor, on hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression and on endogenous VEGF responses to hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-162
11585776-3	2001	Because hypoxia is a major stimulus for VEGF production, we examined the effects of LY294002, a selective PI3K inhibitor, on hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression and on endogenous VEGF responses to hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	endothelial PAS domain protein 1	Homo sapiens	167-177
11585776-5	2001	LY294002 inhibited HIF-1alpha induction and phosphorylation under hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
11585776-10	2001	The decreased HIF-1alpha expression was not dependent on VHL interaction because a renal carcinoma cell line with VHL mutation and constitutive high HIF-1alpha expression also showed down-regulation of HIF-1alpha after treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
11585776-10	2001	The decreased HIF-1alpha expression was not dependent on VHL interaction because a renal carcinoma cell line with VHL mutation and constitutive high HIF-1alpha expression also showed down-regulation of HIF-1alpha after treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-159
11585776-10	2001	The decreased HIF-1alpha expression was not dependent on VHL interaction because a renal carcinoma cell line with VHL mutation and constitutive high HIF-1alpha expression also showed down-regulation of HIF-1alpha after treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-159
11598010-3	2001	Antisense p85alpha oligonucleotide or LY294002, a selective inhibitor of PI3-kinase, independently inhibited the formation of erythropoietin-dependent colonies.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	erythropoietin	Homo sapiens	126-140
11477102-8	2001	IL-18-induced adhesion molecule expression appears to be mediated through nuclear factor kappa B (NF kappa B) and phosphatidyl-inositol 3 kinase (PI 3-kinase) since addition of inhibitors to either NF kappa B (pyrrolidine dithiocarbamate and N-acetyl-l-cysteine) or PI 3-kinase (LY294002) inhibited RA synovial fibroblast VCAM-1 expression by 50 to 60%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	279-287	interleukin 18	Homo sapiens	0-5
11722431-6	2001	LY294002 and GF109203X (inhibitors of PI3-K and PKC respectively) completely or partially inhibited this synergistic action.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	38-51
11485830-6	2001	The activity of PI 3-K is essential for PKC zeta activation, and LY294002 blocks both monocytic differentiation of HL-60 cells and activation of PKC zeta during PMA-induced cell differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	protein kinase C zeta	Homo sapiens	145-153
11568168-5	2001	The phosphorylation of Akt decreases in a time-dependent manner when incubated with the PI3-kinase inhibitor, LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-119	AKT serine/threonine kinase 1	Bos taurus	23-26
11590203-4	2001	Activation of both ERK and NF-kappaB was blocked by wortmannin and LY294002, specific inhibitors of PI 3-K. Wortmannin also inhibited the Fc receptor-mediated increase in the cytosolic calcium concentration, but it did not block immunoglobulin G (IgG)-mediated phagocytosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	mitogen-activated protein kinase 1	Homo sapiens	19-22
11590203-4	2001	Activation of both ERK and NF-kappaB was blocked by wortmannin and LY294002, specific inhibitors of PI 3-K. Wortmannin also inhibited the Fc receptor-mediated increase in the cytosolic calcium concentration, but it did not block immunoglobulin G (IgG)-mediated phagocytosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	nuclear factor kappa B subunit 1	Homo sapiens	27-36
11562426-9	2001	Furthermore, LY294002, a PI3-K inhibitor and a quercetin derivative, inhibited Ang II-induced JNK activation as well as Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	angiotensinogen	Rattus norvegicus	79-85
11562426-9	2001	Furthermore, LY294002, a PI3-K inhibitor and a quercetin derivative, inhibited Ang II-induced JNK activation as well as Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	mitogen-activated protein kinase 8	Rattus norvegicus	94-97
11562426-9	2001	Furthermore, LY294002, a PI3-K inhibitor and a quercetin derivative, inhibited Ang II-induced JNK activation as well as Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	120-123
11562426-10	2001	Finally, Ang II-induced [(3)H]leucine incorporation was abolished by both quercetin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	angiotensinogen	Rattus norvegicus	9-15
11593401-6	2001	Using cells engineered with inducible p16 we showed that Cyclin D/CDK4/6 activity was required for v-Src to increase expression of cyclin A but not cyclin E. To determine which downstream kinases mediated these effects of v-Src we added pharmacological inhibitors of phosphatidylinositol 3-kinase (PI3-K), LY294002 or mitogen activated protein kinase kinase (MEK), U0126.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	306-314	proliferating cell nuclear antigen	Homo sapiens	57-63
11557296-9	2001	Furthermore, the signaling pathway triggering beta 2 integrin-dependent adhesion of equine PMN to IC and subsequent generation of respiratory burst activity is inhibited by the specific phosphatidylinositol 3-kinase (PI3K) antagonists wortmannin and LY294002 with IC(50) (concentration at which 50% inhibition is achieved) similar to the published values for inhibition of PI3K enzymatic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	250-258	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	46-52
11557296-10	2001	In contrast, PMA-induced activation of beta 2 integrin-dependent adhesion and respiratory burst activity are wortmannin and LY294002 insensitive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	39-45
11593406-6	2001	Inhibition of Akt activation by the PI3-K inhibitor LY294002 partially blocked IL-6 triggered MEK/MAPK activation and proliferation in MM.1S cells, suggesting cross-talk between PI3-K and MEK signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	AKT serine/threonine kinase 1	Homo sapiens	14-17
11593415-10	2001	Downregulation of constitutively active Akt by PI-3 kinase inhibitors (wortmannin and LY-294002), dominant negative Akt or PTEN, renders LNCap cells sensitive to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-95	AKT serine/threonine kinase 1	Homo sapiens	40-43
11418622-6	2001	Expression of constitutively active Akt in BaF3/Mpl cells restored the ability of thrombopoietin to promote cell cycling in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	thymoma viral proto-oncogene 1	Mus musculus	36-39
11593415-10	2001	Downregulation of constitutively active Akt by PI-3 kinase inhibitors (wortmannin and LY-294002), dominant negative Akt or PTEN, renders LNCap cells sensitive to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-95	TNF superfamily member 10	Homo sapiens	162-167
11593406-6	2001	Inhibition of Akt activation by the PI3-K inhibitor LY294002 partially blocked IL-6 triggered MEK/MAPK activation and proliferation in MM.1S cells, suggesting cross-talk between PI3-K and MEK signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	interleukin 6	Homo sapiens	79-83
11593406-6	2001	Inhibition of Akt activation by the PI3-K inhibitor LY294002 partially blocked IL-6 triggered MEK/MAPK activation and proliferation in MM.1S cells, suggesting cross-talk between PI3-K and MEK signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	mitogen-activated protein kinase kinase 7	Homo sapiens	94-97
11593406-6	2001	Inhibition of Akt activation by the PI3-K inhibitor LY294002 partially blocked IL-6 triggered MEK/MAPK activation and proliferation in MM.1S cells, suggesting cross-talk between PI3-K and MEK signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	mitogen-activated protein kinase kinase 7	Homo sapiens	188-191
11593406-8	2001	LY294002 completely abrogates this signaling cascade, further confirming the importance of PI3-K/Akt signaling in conferring the protective effect of IL-6 against Dex-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 6	Homo sapiens	150-154
11593406-9	2001	Finally, we show that IL-6 triggered PI3-K/Akt signaling in MM.1S cells inactivates forkhead transcriptional factor (FKHR), with related G1/S phase transition, whereas LY294002 blocks this signaling, resulting in upregulation of p27(KIP1) and G1 growth arrest.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	interleukin 6	Homo sapiens	22-26
11432865-6	2001	Suppression of Akt activity both by wortmannin and LY-294002 or by a dominant negative Akt mutant abolished the anti-apoptotic effect of HDL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-60	AKT serine/threonine kinase 1	Homo sapiens	15-18
11418622-4	2001	Treatment of BaF3/Mpl cells and megakaryocytes with the phosphatidylinositol 3-kinase inhibitor LY294002 inhibited mitotic and endomitotic cell cycl-ing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	myeloproliferative leukemia virus oncogene	Mus musculus	18-21
11418622-5	2001	BaF3/Mpl cells treated with thrombopoietin and LY294002 were blocked in G(1), whereas megakaryocyte progenitors treated with thrombopoietin and LY294002 showed both a G(1) and a G(2) cell cycle block.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	myeloproliferative leukemia virus oncogene	Mus musculus	5-8
11418622-6	2001	Expression of constitutively active Akt in BaF3/Mpl cells restored the ability of thrombopoietin to promote cell cycling in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	myeloproliferative leukemia virus oncogene	Mus musculus	48-51
11418622-6	2001	Expression of constitutively active Akt in BaF3/Mpl cells restored the ability of thrombopoietin to promote cell cycling in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	thrombopoietin	Mus musculus	82-96
11532856-7	2001	Finally, LY 294002 induced the blockade of phosphatidylinositol 3-kinase (PI3K), one of the principal transducers of HGF/Met receptor signalling, prevented the enhancement of HIF-1 DNA binding and JNK activity, but the inhibition of p42/44 MAPK phosphorylation with PD 98059 was ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-18	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	43-72
11445586-4	2001	In contrast, treatment with wortmannin or LY294002, inhibitors of phosphatidylinositol 3 (PI3)-kinase, resulted in a strong enhancement of the VEGF-induced tissue factor production, indicating a negative regulatory role of the PI3-kinase on tissue factor-inducing pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	vascular endothelial growth factor A	Homo sapiens	143-147
11445586-4	2001	In contrast, treatment with wortmannin or LY294002, inhibitors of phosphatidylinositol 3 (PI3)-kinase, resulted in a strong enhancement of the VEGF-induced tissue factor production, indicating a negative regulatory role of the PI3-kinase on tissue factor-inducing pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	coagulation factor III, tissue factor	Homo sapiens	156-169
11445586-4	2001	In contrast, treatment with wortmannin or LY294002, inhibitors of phosphatidylinositol 3 (PI3)-kinase, resulted in a strong enhancement of the VEGF-induced tissue factor production, indicating a negative regulatory role of the PI3-kinase on tissue factor-inducing pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	coagulation factor III, tissue factor	Homo sapiens	241-254
11593385-8	2001	Meanwhile, the IL-6-induced Mcl-1 up-regulation was effectively abolished by treatment with PI 3-K inhibitors, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	interleukin 6	Homo sapiens	15-19
11593385-8	2001	Meanwhile, the IL-6-induced Mcl-1 up-regulation was effectively abolished by treatment with PI 3-K inhibitors, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	28-33
11500316-6	2001	The effects of insulin on FA esterification (stimulation) and oxidation (inhibition) during contraction were reduced in the presence of the phosphatidylinositol 3-kinase inhibitor LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-189	insulin	Homo sapiens	15-22
11552986-7	2001	LY294002, an inhibitor of phosphatidylinositol 3"-kinase, blocked Akt activation by plasma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	66-69
11532856-7	2001	Finally, LY 294002 induced the blockade of phosphatidylinositol 3-kinase (PI3K), one of the principal transducers of HGF/Met receptor signalling, prevented the enhancement of HIF-1 DNA binding and JNK activity, but the inhibition of p42/44 MAPK phosphorylation with PD 98059 was ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-18	hepatocyte growth factor	Homo sapiens	117-120
11532856-7	2001	Finally, LY 294002 induced the blockade of phosphatidylinositol 3-kinase (PI3K), one of the principal transducers of HGF/Met receptor signalling, prevented the enhancement of HIF-1 DNA binding and JNK activity, but the inhibition of p42/44 MAPK phosphorylation with PD 98059 was ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	175-180
11855663-8	2001	This stimulation of 2-DG uptake was, in all instances, blocked by the PI 3-kinase inhibitors wortmannin and LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-117	WAP four-disulfide core domain 15B	Rattus norvegicus	70-74
11532856-7	2001	Finally, LY 294002 induced the blockade of phosphatidylinositol 3-kinase (PI3K), one of the principal transducers of HGF/Met receptor signalling, prevented the enhancement of HIF-1 DNA binding and JNK activity, but the inhibition of p42/44 MAPK phosphorylation with PD 98059 was ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-18	mitogen-activated protein kinase 8	Homo sapiens	197-200
11532856-7	2001	Finally, LY 294002 induced the blockade of phosphatidylinositol 3-kinase (PI3K), one of the principal transducers of HGF/Met receptor signalling, prevented the enhancement of HIF-1 DNA binding and JNK activity, but the inhibition of p42/44 MAPK phosphorylation with PD 98059 was ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-18	cyclin dependent kinase 20	Homo sapiens	233-236
11549666-2	2001	Insulin stimulation of glycogen synthase activity as well as phosphorylation of MAPK, p70 S6 kinase, and protein kinase B (Akt) were blocked by the phosphatidylinositol 3-kinase inhibitors wortmannin (50 nM) and LY294002 (10 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	protein tyrosine kinase 2 beta	Homo sapiens	86-121
11517177-0	2001	LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	insulin-like growth factor 1	Rattus norvegicus	97-102
11517177-10	2001	These studies demonstrated that treatment with LY 294002 completely abrogated GH-induced IGF-I gene expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-56	insulin-like growth factor 1	Rattus norvegicus	89-94
11527900-4	2001	Here, we investigated the role of phosphatidylinositol 3-kinase (PI3K), a lipid and protein kinase involved in the regulation of several biological aspects of somatic cells, on human sperm motility by using the specific PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	235-243	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	34-63
11549666-2	2001	Insulin stimulation of glycogen synthase activity as well as phosphorylation of MAPK, p70 S6 kinase, and protein kinase B (Akt) were blocked by the phosphatidylinositol 3-kinase inhibitors wortmannin (50 nM) and LY294002 (10 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	212-220	AKT serine/threonine kinase 1	Homo sapiens	123-126
11435425-8	2001	Importantly, the pharmacologic PI 3"-kinase inhibitor, LY294002, blocked TEL-JAK2 factor-independent growth and phosphorylation of protein kinase B.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	ETS variant transcription factor 6	Homo sapiens	73-76
11509654-7	2001	Notably, the PI 3-kinase inhibitor, LY294002, completely blocked cytokine-induced Cdk2 activation and cell growth in irradiated 32D cells but not in nonirradiated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	cyclin-dependent kinase 2	Mus musculus	82-86
11591128-4	2001	LY294002, an inhibitor of PI3K, but not PD98059, an inhibitor of MEK, markedly reduced the response of these neurons to CNTF, as did dominant-negative PI3K, dominant-negative Akt, and overexpression of Ruk (a natural PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ciliary neurotrophic factor	Mus musculus	120-124
11591128-4	2001	LY294002, an inhibitor of PI3K, but not PD98059, an inhibitor of MEK, markedly reduced the response of these neurons to CNTF, as did dominant-negative PI3K, dominant-negative Akt, and overexpression of Ruk (a natural PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	SH3-domain kinase binding protein 1	Mus musculus	202-205
11565871-6	2001	Finally, using semiquantitative reverse transcriptase-polymerase chain reaction, the authors demonstrated that LY294002 decreased messenger (m)RNA levels for both MMPs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	matrix metallopeptidase 2	Rattus norvegicus	163-167
11435425-8	2001	Importantly, the pharmacologic PI 3"-kinase inhibitor, LY294002, blocked TEL-JAK2 factor-independent growth and phosphorylation of protein kinase B.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	Janus kinase 2	Homo sapiens	77-81
11435425-8	2001	Importantly, the pharmacologic PI 3"-kinase inhibitor, LY294002, blocked TEL-JAK2 factor-independent growth and phosphorylation of protein kinase B.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	protein tyrosine kinase 2 beta	Homo sapiens	131-147
11500826-6	2001	Monocytes treated with a reversible PI3K inhibitor (LY294002) displayed enhanced apoptosis, while LPS and TNF-alpha partially protected against apoptosis mediated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	interferon regulatory factor 6	Homo sapiens	98-101
11435419-7	2001	Placing PYK2 upstream of both PI3K and Akt activation, PYK2 activated Akt through a PI3K-dependent pathway, and either a dominant negative form of Akt or the PI3K inhibitor LY294002 blocked PYK2-stimulated NF-kappa B-dependent transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	protein tyrosine kinase 2 beta	Homo sapiens	8-12
11435419-7	2001	Placing PYK2 upstream of both PI3K and Akt activation, PYK2 activated Akt through a PI3K-dependent pathway, and either a dominant negative form of Akt or the PI3K inhibitor LY294002 blocked PYK2-stimulated NF-kappa B-dependent transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	protein tyrosine kinase 2 beta	Homo sapiens	55-59
11435419-7	2001	Placing PYK2 upstream of both PI3K and Akt activation, PYK2 activated Akt through a PI3K-dependent pathway, and either a dominant negative form of Akt or the PI3K inhibitor LY294002 blocked PYK2-stimulated NF-kappa B-dependent transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	protein tyrosine kinase 2 beta	Homo sapiens	55-59
11435419-7	2001	Placing PYK2 upstream of both PI3K and Akt activation, PYK2 activated Akt through a PI3K-dependent pathway, and either a dominant negative form of Akt or the PI3K inhibitor LY294002 blocked PYK2-stimulated NF-kappa B-dependent transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	nuclear factor kappa B subunit 1	Homo sapiens	206-216
11489535-4	2001	Phosphatidylinositol (PI)3-kinase inhibitors (LY294002 and wortmannin) but not a mitogen-activated protein kinase kinase inhibitor (PD98059) completely suppressed the IL-6-promoted survival of the cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	interleukin 6	Rattus norvegicus	167-171
11489535-6	2001	IL-6 stimulated phosphorylation of Akt, a downstream effector of PI3 kinase, and in the presence of LY294002, the phosphorylation of Akt was reduced to basal level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	interleukin 6	Rattus norvegicus	0-4
11489535-6	2001	IL-6 stimulated phosphorylation of Akt, a downstream effector of PI3 kinase, and in the presence of LY294002, the phosphorylation of Akt was reduced to basal level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	AKT serine/threonine kinase 1	Rattus norvegicus	35-38
11489535-6	2001	IL-6 stimulated phosphorylation of Akt, a downstream effector of PI3 kinase, and in the presence of LY294002, the phosphorylation of Akt was reduced to basal level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	AKT serine/threonine kinase 1	Rattus norvegicus	133-136
11490019-7	2001	Phosphatidylinositol 3-phosphate kinase and Akt activities were also induced by C5b-9, and the phosphatidylinositol 3-phosphate kinase inhibitor LY294002 reversed the protective effect of C5b-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	AKT serine/threonine kinase 1	Homo sapiens	44-47
11490019-7	2001	Phosphatidylinositol 3-phosphate kinase and Akt activities were also induced by C5b-9, and the phosphatidylinositol 3-phosphate kinase inhibitor LY294002 reversed the protective effect of C5b-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	complement C5	Homo sapiens	80-83
11490019-7	2001	Phosphatidylinositol 3-phosphate kinase and Akt activities were also induced by C5b-9, and the phosphatidylinositol 3-phosphate kinase inhibitor LY294002 reversed the protective effect of C5b-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	complement C5	Homo sapiens	188-191
11521195-6	2001	The role of Akt in the inhibition of the differentiation program was confirmed by using the inhibitor of Class I PI3 kinases LY29400, which restores IGF-I-induced differentiation of H19-7/IGF-IR/IRS-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-132	AKT serine/threonine kinase 1	Rattus norvegicus	12-15
11521195-6	2001	The role of Akt in the inhibition of the differentiation program was confirmed by using the inhibitor of Class I PI3 kinases LY29400, which restores IGF-I-induced differentiation of H19-7/IGF-IR/IRS-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-132	insulin-like growth factor 1	Rattus norvegicus	149-154
11521195-6	2001	The role of Akt in the inhibition of the differentiation program was confirmed by using the inhibitor of Class I PI3 kinases LY29400, which restores IGF-I-induced differentiation of H19-7/IGF-IR/IRS-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-132	insulin receptor substrate 1	Rattus norvegicus	195-200
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	cyclin dependent kinase 20	Homo sapiens	54-57
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	interferon induced protein 44	Homo sapiens	58-61
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	mitogen-activated protein kinase 1	Homo sapiens	62-65
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	71-74
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	hepatocyte growth factor	Homo sapiens	112-115
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	vascular endothelial growth factor A	Homo sapiens	147-151
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	234-238
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	vascular endothelial growth factor A	Homo sapiens	243-247
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	mitogen-activated protein kinase kinase 7	Homo sapiens	14-17
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-198	hepatocyte growth factor	Homo sapiens	112-115
11500826-6	2001	Monocytes treated with a reversible PI3K inhibitor (LY294002) displayed enhanced apoptosis, while LPS and TNF-alpha partially protected against apoptosis mediated by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	tumor necrosis factor	Homo sapiens	106-115
11349127-8	2001	The effects of insulin on membrane turnover and membrane conductance were inhibited by blockers of phosphoinositide 3-kinase LY294002 and wortmannin or by disrupting microtubule assembly with nocodazole.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	insulin	Homo sapiens	15-22
11424089-10	2001	Treatment with PI3K inhibitor, wortmannin or LY294002, abrogated not only PKCdelta translocation but the subsequent transcriptional activation of HSF and HIF-1 by hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	protein kinase C delta	Homo sapiens	74-82
11424089-10	2001	Treatment with PI3K inhibitor, wortmannin or LY294002, abrogated not only PKCdelta translocation but the subsequent transcriptional activation of HSF and HIF-1 by hypoxia.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	interleukin 6	Homo sapiens	146-149
11483646-2	2001	Neuroprotection was abrogated by PD98059 and LY294002, which inhibit the mitogen activated protein kinase (MAPK) and the phosphatidylinositol-3-kinase (PI-3-K) pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	mitogen activated protein kinase 3	Rattus norvegicus	107-111
11483646-2	2001	Neuroprotection was abrogated by PD98059 and LY294002, which inhibit the mitogen activated protein kinase (MAPK) and the phosphatidylinositol-3-kinase (PI-3-K) pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	121-150
11483646-3	2001	Cultured astrocytes lost the ability to produce transforming growth factor-beta1 (TGF-beta1) in response to mGlu2/3 receptor agonists when co-incubated with PD98059 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	transforming growth factor, beta 1	Rattus norvegicus	82-91
11278864-4	2001	The activity of PI3Kalpha in purified human monocytes was evident within 30 s. MCP-1-induced monocyte arrest was significantly inhibited both by wortmannin (n = 4; p &lt; 0.01) and LY294002 (n = 4; p &lt; 0.01) with restoration of the rolling phenotype (p &lt; 0.05 for both inhibitors, compared with rolling of control monocytes after MCP-1 treatment).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	16-25
11278864-4	2001	The activity of PI3Kalpha in purified human monocytes was evident within 30 s. MCP-1-induced monocyte arrest was significantly inhibited both by wortmannin (n = 4; p &lt; 0.01) and LY294002 (n = 4; p &lt; 0.01) with restoration of the rolling phenotype (p &lt; 0.05 for both inhibitors, compared with rolling of control monocytes after MCP-1 treatment).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	C-C motif chemokine ligand 2	Homo sapiens	79-84
11350959-2	2001	Treatment with a phosphatidylinositol 3-kinase inhibitor, LY 294002, or expression of a dominant negative mutant of p85 (regulatory component of phosphatidylinositol 3-kinase) inhibited UVB-induced Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-67	AKT serine/threonine kinase 1	Homo sapiens	198-201
11457886-8	2001	However, after inhibition of the PI3K/Akt-1 pathway, a marked decrease in the expression of the antiapoptotic molecule Mcl-1, but not other Bcl-2 family members was observed, and Mcl-1 rescued macrophages from LY294002-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	179-184
11453646-3	2001	The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	tumor necrosis factor	Mus musculus	52-60
11453646-3	2001	The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	thymoma viral proto-oncogene 1	Mus musculus	75-78
11453646-3	2001	The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	mitogen-activated protein kinase 1	Mus musculus	90-93
11453646-3	2001	The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	thymoma viral proto-oncogene 1	Mus musculus	132-135
11457886-4	2001	Akt-1 was constitutively activated in human macrophages and addition of the PI3K inhibitor, LY294002, suppressed the activation of Akt-1 and induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	0-5
11457886-4	2001	Akt-1 was constitutively activated in human macrophages and addition of the PI3K inhibitor, LY294002, suppressed the activation of Akt-1 and induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	131-136
11457886-8	2001	However, after inhibition of the PI3K/Akt-1 pathway, a marked decrease in the expression of the antiapoptotic molecule Mcl-1, but not other Bcl-2 family members was observed, and Mcl-1 rescued macrophages from LY294002-induced cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	AKT serine/threonine kinase 1	Homo sapiens	38-43
11352916-6	2001	Pretreatment with an inhibitor of either one, i.e. LY294002 for phosphatidylinositol-3"-OH kinase or rapamycin for FRAP/mTOR, completely inhibited 4E-BP1 phosphorylation and decreased the c-Fos synthesis induced by HGF/SF down to the level found in EGF-induced cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	147-153
11352916-6	2001	Pretreatment with an inhibitor of either one, i.e. LY294002 for phosphatidylinositol-3"-OH kinase or rapamycin for FRAP/mTOR, completely inhibited 4E-BP1 phosphorylation and decreased the c-Fos synthesis induced by HGF/SF down to the level found in EGF-induced cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	188-193
11352916-6	2001	Pretreatment with an inhibitor of either one, i.e. LY294002 for phosphatidylinositol-3"-OH kinase or rapamycin for FRAP/mTOR, completely inhibited 4E-BP1 phosphorylation and decreased the c-Fos synthesis induced by HGF/SF down to the level found in EGF-induced cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	hepatocyte growth factor	Homo sapiens	215-221
11350959-5	2001	The expression of a dominant negative mutant of p85 or treatment with LY 294002 also inhibited UVB-induced Erk phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-79	mitogen-activated protein kinase 1	Homo sapiens	107-110
11457733-6	2001	In the prostate carcinoma-derived cell lines PC-3 and DU145, insulin- and epidermal growth factor-induced expression of HIF-1alpha was inhibited by the PI3K-specific inhibitors LY294002 and wortmannin in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	insulin	Homo sapiens	61-68
11406465-9	2001	LY-294002 [a phosphatidylinositol-3 (PI3) kinase inhibitor] blocked angiotensin II-stimulated ERK1/2 activation in SHR but not in WKY, whereas bisindolylmaleimide [a protein kinase C (PKC) inhibitor] was ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	angiotensinogen	Rattus norvegicus	68-82
11406465-9	2001	LY-294002 [a phosphatidylinositol-3 (PI3) kinase inhibitor] blocked angiotensin II-stimulated ERK1/2 activation in SHR but not in WKY, whereas bisindolylmaleimide [a protein kinase C (PKC) inhibitor] was ineffective.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	mitogen activated protein kinase 3	Rattus norvegicus	94-100
11457733-6	2001	In the prostate carcinoma-derived cell lines PC-3 and DU145, insulin- and epidermal growth factor-induced expression of HIF-1alpha was inhibited by the PI3K-specific inhibitors LY294002 and wortmannin in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-130
11408264-7	2001	Insulin had no effect on Ins(3,4,5,6)P(4) levels, and the inhibitory effects of insulin and IGF-I on chloride secretion were fully reversed by the PI 3-kinase inhibitors wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-194	insulin	Homo sapiens	80-87
11408264-7	2001	Insulin had no effect on Ins(3,4,5,6)P(4) levels, and the inhibitory effects of insulin and IGF-I on chloride secretion were fully reversed by the PI 3-kinase inhibitors wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-194	insulin like growth factor 1	Homo sapiens	92-97
11457733-6	2001	In the prostate carcinoma-derived cell lines PC-3 and DU145, insulin- and epidermal growth factor-induced expression of HIF-1alpha was inhibited by the PI3K-specific inhibitors LY294002 and wortmannin in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	epidermal growth factor	Homo sapiens	74-97
11457733-10	2001	Vascular endothelial growth factor reporter gene activity was induced by insulin in PC-3 cells and was inhibited by the PI3K inhibitor LY294002 and by the coexpression of a HIF-1 dominant negative construct.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	vascular endothelial growth factor A	Homo sapiens	0-34
11457733-10	2001	Vascular endothelial growth factor reporter gene activity was induced by insulin in PC-3 cells and was inhibited by the PI3K inhibitor LY294002 and by the coexpression of a HIF-1 dominant negative construct.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	insulin	Homo sapiens	73-80
11418685-4	2001	We further show that Syk activation by c48/80 is blocked by the protein kinase C inhibitor GF109203X, by the phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002, by EGTA, and by the selective src-like kinase inhibitor PP1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	spleen associated tyrosine kinase	Rattus norvegicus	21-24
11406568-7	2001	Down-regulation of Akt kinase activity by a phosphatidylinositol 3"-kinase inhibitor (LY294002) also resulted in enhancement of TRAIL-mediated apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	TNF superfamily member 10	Homo sapiens	128-133
11418646-5	2001	Pretreatment of cells with N,N-dimethylsphingosine (DMS), an inhibitor of SphK, or LY 294002, an inhibitor of PI3K that acts upstream of Akt, increased the number of apoptotic cells induced by TNF-alpha in Ad5IkappaB-infected Huh-7 and Hc cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-92	AKT serine/threonine kinase 1	Homo sapiens	137-140
11418646-5	2001	Pretreatment of cells with N,N-dimethylsphingosine (DMS), an inhibitor of SphK, or LY 294002, an inhibitor of PI3K that acts upstream of Akt, increased the number of apoptotic cells induced by TNF-alpha in Ad5IkappaB-infected Huh-7 and Hc cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-92	tumor necrosis factor	Homo sapiens	193-202
11418646-5	2001	Pretreatment of cells with N,N-dimethylsphingosine (DMS), an inhibitor of SphK, or LY 294002, an inhibitor of PI3K that acts upstream of Akt, increased the number of apoptotic cells induced by TNF-alpha in Ad5IkappaB-infected Huh-7 and Hc cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-92	MIR7-3 host gene	Homo sapiens	226-231
11390615-5	2001	We show that the specific PI3 kinase inhibitor, LY294002, completely abrogates the ability of a BRLF1 adenovirus vector to induce the lytic form of EBV infection, while not affecting lytic infection induced by a BZLF1 adenovirus vector.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	BRLF1	Human gammaherpesvirus 4	96-101
11283022-3	2001	By taking advantage of a well known inhibitor of PI 3-kinase, LY294002, we demonstrated that pretreatment of L6 myotubes with LY294002 blocked insulin-induced PKCbetaII exon inclusion as well as phosphorylation of SRp40.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	insulin	Homo sapiens	143-150
11283022-3	2001	By taking advantage of a well known inhibitor of PI 3-kinase, LY294002, we demonstrated that pretreatment of L6 myotubes with LY294002 blocked insulin-induced PKCbetaII exon inclusion as well as phosphorylation of SRp40.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	insulin	Homo sapiens	143-150
11283022-3	2001	By taking advantage of a well known inhibitor of PI 3-kinase, LY294002, we demonstrated that pretreatment of L6 myotubes with LY294002 blocked insulin-induced PKCbetaII exon inclusion as well as phosphorylation of SRp40.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	serine and arginine rich splicing factor 5	Homo sapiens	214-219
11287413-4	2001	However, in the presence of the specific phosphatidylinositol 3-kinase inhibitor LY294002 or the selective Src family kinase inhibitor PP1, although cells retained their response to HGF for increasing integrin alpha(2) expression, they failed to scatter, indicating that increased expression of integrin alpha(2) alone is not sufficient for cell scattering.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	hepatocyte growth factor	Canis lupus familiaris	182-185
11287413-4	2001	However, in the presence of the specific phosphatidylinositol 3-kinase inhibitor LY294002 or the selective Src family kinase inhibitor PP1, although cells retained their response to HGF for increasing integrin alpha(2) expression, they failed to scatter, indicating that increased expression of integrin alpha(2) alone is not sufficient for cell scattering.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	integrin subunit alpha 2	Canis lupus familiaris	201-217
11287413-4	2001	However, in the presence of the specific phosphatidylinositol 3-kinase inhibitor LY294002 or the selective Src family kinase inhibitor PP1, although cells retained their response to HGF for increasing integrin alpha(2) expression, they failed to scatter, indicating that increased expression of integrin alpha(2) alone is not sufficient for cell scattering.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	integrin subunit alpha 2	Canis lupus familiaris	201-218
11335710-3	2001	Expression of Deltap85 and incubation with LY294002 both inhibited IL-3-induced activation of Mek, Erk1, and Erk2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	interleukin 3	Homo sapiens	67-71
11335710-3	2001	Expression of Deltap85 and incubation with LY294002 both inhibited IL-3-induced activation of Mek, Erk1, and Erk2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	mitogen-activated protein kinase kinase 7	Homo sapiens	94-97
11335710-3	2001	Expression of Deltap85 and incubation with LY294002 both inhibited IL-3-induced activation of Mek, Erk1, and Erk2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	mitogen-activated protein kinase 3	Homo sapiens	99-103
11335710-3	2001	Expression of Deltap85 and incubation with LY294002 both inhibited IL-3-induced activation of Mek, Erk1, and Erk2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	mitogen-activated protein kinase 1	Homo sapiens	109-113
11390502-4	2001	We also detected activation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway after GM-CSF treatment which was inhibited by treatment with the PI 3-kinase inhibitors, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	191-199	colony stimulating factor 2	Homo sapiens	93-99
11422447-7	2001	The S1P-evoked activation of Erk1 was totally blocked in astrocytes pretreated with a combination of either phorbol ester (24 h) and LY294002, or phorbol ester (24 h) and pertussis toxin (PTX).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
11356694-7	2001	Addition of the specific PI 3-K inhibitor LY294002 to the granulosa cell cultures decreased Akt phosphorylation and induced apoptosis in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	AKT serine/threonine kinase 1	Rattus norvegicus	92-95
11274155-5	2001	Pretreatment with LY 294002 (a selective PI3-kinase inhibitor), however, inhibited both hNQO1-ARE-luciferase expression and endogenous NQO1 protein induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-27	NAD(P)H quinone dehydrogenase 1	Homo sapiens	88-93
11274155-5	2001	Pretreatment with LY 294002 (a selective PI3-kinase inhibitor), however, inhibited both hNQO1-ARE-luciferase expression and endogenous NQO1 protein induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-27	NAD(P)H quinone dehydrogenase 1	Homo sapiens	89-93
11389054-4	2001	LY294002 also decreased the expression of endogenous COX-2 protein and a luciferase construct driven by COX-2 promoter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-58
11389054-4	2001	LY294002 also decreased the expression of endogenous COX-2 protein and a luciferase construct driven by COX-2 promoter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	104-109
11422447-7	2001	The S1P-evoked activation of Erk1 was totally blocked in astrocytes pretreated with a combination of either phorbol ester (24 h) and LY294002, or phorbol ester (24 h) and pertussis toxin (PTX).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	mitogen-activated protein kinase 3	Homo sapiens	29-33
11467306-7	2001	The S1P-evoked activation of Erk1 was totally blocked in astrocytes pretreated with a combination of either phorbol ester (24 h) and LY294002, or phorbol ester (24 h) and pertussis toxin (PTX).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
11467306-7	2001	The S1P-evoked activation of Erk1 was totally blocked in astrocytes pretreated with a combination of either phorbol ester (24 h) and LY294002, or phorbol ester (24 h) and pertussis toxin (PTX).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	mitogen-activated protein kinase 3	Mus musculus	29-33
11422447-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
11467306-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
11422447-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	sphingosine-1-phosphate receptor 1	Mus musculus	166-169
11467306-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	sphingosine-1-phosphate receptor 1	Mus musculus	166-169
11369709-5	2001	Using the specific pharmacological inhibitors of PI 3-kinase, Wortmannin and LY294002, we demonstrate that PI 3-kinase activity is vital for BCR-induced NF-kappaB DNA-binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	153-162
11392472-4	2001	N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated neutrophil adhesion was inhibited by wortmannin and LY294002, two unrelated PI-3K inhibitors, whereas phorbol myristate acetate (PMA)-induced neutrophil adhesion was not inhibited by them.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	formyl peptide receptor 1	Homo sapiens	41-45
11381049-16	2001	Treatment of the cells with the PI3K inhibitors, wortmannin or LY294002, caused inhibition of both EGF-stimulated cell proliferation and PLCgamma1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	pro-epidermal growth factor	Oryctolagus cuniculus	99-102
11381049-16	2001	Treatment of the cells with the PI3K inhibitors, wortmannin or LY294002, caused inhibition of both EGF-stimulated cell proliferation and PLCgamma1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	Oryctolagus cuniculus	137-146
11359803-4	2001	When cells are costimulated with ICAM-1 in the presence of the inhibitors wortmannin or LY294002, proliferation is blocked, but increases in IL-2 mRNA levels and protein production are not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	intercellular adhesion molecule 1	Homo sapiens	33-39
11412835-4	2001	The broad range protein tyrosine kinase inhibitor genistein and the phosphatidylinositol 3-kinase inhibitors wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one) also blocked adenosine A3 receptor stimulation of p42/p44 MAPK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-183	interferon induced protein 44	Homo sapiens	239-242
11391701-7	2001	Western blotting analysis demonstrated that treatment with 17beta-estradiol induced the phosphorylation of Akt within 5 min, which was suppressed by pretreatment with LY294002 and ICI182780.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	AKT serine/threonine kinase 1	Homo sapiens	107-110
11359902-5	2001	A PI3K-specific inhibitor, LY294002, also upregulated IRS-2, providing evidence that it was the suppression of the PI3K pathway that was responsible for the message upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	insulin receptor substrate 2	Homo sapiens	54-59
11359902-6	2001	In addition, PTEN, LY294002, and rapamycin, an inhibitor of mammalian target of rapamycin, caused a reduction in the molecular weight of IRS-2 and an increase in the association of IRS-2 with PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	mechanistic target of rapamycin kinase	Homo sapiens	60-89
11359902-6	2001	In addition, PTEN, LY294002, and rapamycin, an inhibitor of mammalian target of rapamycin, caused a reduction in the molecular weight of IRS-2 and an increase in the association of IRS-2 with PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	insulin receptor substrate 2	Homo sapiens	137-142
11359902-6	2001	In addition, PTEN, LY294002, and rapamycin, an inhibitor of mammalian target of rapamycin, caused a reduction in the molecular weight of IRS-2 and an increase in the association of IRS-2 with PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	insulin receptor substrate 2	Homo sapiens	181-186
11412835-4	2001	The broad range protein tyrosine kinase inhibitor genistein and the phosphatidylinositol 3-kinase inhibitors wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one) also blocked adenosine A3 receptor stimulation of p42/p44 MAPK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-183	adenosine receptor A3	Cricetulus griseus	198-219
11412835-4	2001	The broad range protein tyrosine kinase inhibitor genistein and the phosphatidylinositol 3-kinase inhibitors wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one) also blocked adenosine A3 receptor stimulation of p42/p44 MAPK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-183	cyclin dependent kinase 20	Homo sapiens	235-238
11729375-7	2001	Further, two distinct PI 3-kinase inhibitors, wortmannin and LY294002 inhibited the migratory effect of leptin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	leptin	Rattus norvegicus	104-110
11355882-5	2001	In addition, PTX induced phosphorylation of Akt and of ERK2, which could be completely blocked by LY294002 and PD098059, respectively, and by genistein or tyrphostin 47 as well.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	mitogen-activated protein kinase 1	Homo sapiens	55-59
11369473-9	2001	Wortmannin or LY294002, PI3-kinase inhibitors, completely inhibited the increases in mEH mRNA and protein by SAAD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	epoxide hydrolase 1, microsomal	Mus musculus	85-88
11358856-3	2001	The phosphoinositide-3-kinase (PI3K) inhibitor LY294002 radiosensitized cells bearing mutant ras oncogenes, but the survival of cells with wild-type ras was not affected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-29
11358816-4	2001	Akt/PKB activation was phosphatidylinositol 3-kinase-dependent and promoted survival because the phosphatidylinositol 3 inhibitors LY294002 and wortmannin inhibited Akt/PKB phosphorylation, Akt/PKB activity, and increased apoptosis only in cells with active Akt/PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	0-3
11340086-5	2001	Activation is blocked completely by wortmannin and LY294002, inhibitors of phosphatidylinositol 3-kinase, suggesting that Akt activation occurs downstream from phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Bos taurus	122-125
11358816-4	2001	Akt/PKB activation was phosphatidylinositol 3-kinase-dependent and promoted survival because the phosphatidylinositol 3 inhibitors LY294002 and wortmannin inhibited Akt/PKB phosphorylation, Akt/PKB activity, and increased apoptosis only in cells with active Akt/PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	4-7
11358816-4	2001	Akt/PKB activation was phosphatidylinositol 3-kinase-dependent and promoted survival because the phosphatidylinositol 3 inhibitors LY294002 and wortmannin inhibited Akt/PKB phosphorylation, Akt/PKB activity, and increased apoptosis only in cells with active Akt/PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	165-168
11358816-4	2001	Akt/PKB activation was phosphatidylinositol 3-kinase-dependent and promoted survival because the phosphatidylinositol 3 inhibitors LY294002 and wortmannin inhibited Akt/PKB phosphorylation, Akt/PKB activity, and increased apoptosis only in cells with active Akt/PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	169-172
11358816-4	2001	Akt/PKB activation was phosphatidylinositol 3-kinase-dependent and promoted survival because the phosphatidylinositol 3 inhibitors LY294002 and wortmannin inhibited Akt/PKB phosphorylation, Akt/PKB activity, and increased apoptosis only in cells with active Akt/PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	165-168
11358816-4	2001	Akt/PKB activation was phosphatidylinositol 3-kinase-dependent and promoted survival because the phosphatidylinositol 3 inhibitors LY294002 and wortmannin inhibited Akt/PKB phosphorylation, Akt/PKB activity, and increased apoptosis only in cells with active Akt/PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	169-172
11358816-4	2001	Akt/PKB activation was phosphatidylinositol 3-kinase-dependent and promoted survival because the phosphatidylinositol 3 inhibitors LY294002 and wortmannin inhibited Akt/PKB phosphorylation, Akt/PKB activity, and increased apoptosis only in cells with active Akt/PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	AKT serine/threonine kinase 1	Homo sapiens	0-7
11358816-6	2001	LY294002 greatly potentiated chemotherapy-induced apoptosis in cells with high Akt/PKB levels, but did not significantly increase chemotherapy-induced apoptosis in cells with low Akt/PKB levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	79-82
11358816-6	2001	LY294002 greatly potentiated chemotherapy-induced apoptosis in cells with high Akt/PKB levels, but did not significantly increase chemotherapy-induced apoptosis in cells with low Akt/PKB levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	83-86
11358816-7	2001	Combined with radiation in cells with active Akt/PKB, LY294002 additively increased apoptosis and inhibited clonogenic growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	45-52
11278310-9	2001	The transient phase of the ERK activity was partially inhibited either by the phosphatidylinositol 3-kinase inhibitor, LY 294002, or the PKC inhibitor, Go 6976.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-128	mitogen-activated protein kinase 1	Homo sapiens	27-30
11278575-5	2001	Concomitant treatment of RBL-2H3 cells with LY294002 or Deltap85 and 2-aminoethyl diphenylborate, a cell-permeant antagonist of D-myo-inositol 1,4,5-trisphosphate receptors, abrogates antigen-induced Ca(2+) signals, whereas either treatment alone gives rise to partial inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	RB transcriptional corepressor like 2	Rattus norvegicus	25-30
11423913-4	2001	Pretreatment with either the MEK1 inhibitor U0126 or PI3-kinase inhibitor LY294002 sensitized BAE cells to TNF-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	tumor necrosis factor	Bos taurus	107-110
11313272-9	2001	The MEK inhibitor PD98059 down-regulated survivin expression in both resting and GM-CSF-stimulated OCI-AML3 cells, whereas the PI3K inhibitor LY294002 inhibited survivin expression only on GM-CSF stimulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	colony stimulating factor 2	Homo sapiens	189-195
11359521-6	2001	Both effects were prevented by PD98059 and LY294002, which inhibit the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI-3-K) pathways, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	115-144
11350893-6	2001	Using the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor LY 294002, we show that this VEGF hypoxia-inducible pathway regulated by HIF-1 alpha is distinct from a PI 3-kinase-dependent pathway, which regulates basal amounts of VEGF, but does not affect inducibility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	vascular endothelial growth factor A	Homo sapiens	93-97
11350893-6	2001	Using the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor LY 294002, we show that this VEGF hypoxia-inducible pathway regulated by HIF-1 alpha is distinct from a PI 3-kinase-dependent pathway, which regulates basal amounts of VEGF, but does not affect inducibility.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-148
11316733-7	2001	Inhibition of ERK activity using PD98059 and PI 3-kinase activity with LY 294002 abrogated the induction of NF-kappaB-dependent transcription by IGF-I, suggesting that both pathways contribute to the effect of IGF-I on NF-kappaBdependent transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-80	insulin like growth factor 1	Bos taurus	145-150
11316733-7	2001	Inhibition of ERK activity using PD98059 and PI 3-kinase activity with LY 294002 abrogated the induction of NF-kappaB-dependent transcription by IGF-I, suggesting that both pathways contribute to the effect of IGF-I on NF-kappaBdependent transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-80	insulin like growth factor 1	Bos taurus	210-215
11316733-11	2001	IGF-I-induced endothelial cell migration was inhibited, in part, by LY 294002 but not PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-77	insulin like growth factor 1	Bos taurus	0-5
11376875-7	2001	RESULTS: TPO up-regulated platelet alpha-granule secretion and aggregation induced by thrombin, which was dose-dependently inhibited by preincubation with wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	thrombopoietin	Homo sapiens	9-12
11376875-7	2001	RESULTS: TPO up-regulated platelet alpha-granule secretion and aggregation induced by thrombin, which was dose-dependently inhibited by preincubation with wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	coagulation factor II, thrombin	Homo sapiens	86-94
11267999-4	2001	Accordingly, ERK1/2 phosphorylation induced by UTP was inhibited by the PI3K inhibitors, wortmannin and LY294002, and the c-src inhibitors, radicicol and PP2, but not by inhibitors of protein kinase C (PKC).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	mitogen-activated protein kinase 3	Homo sapiens	13-19
11376875-9	2001	Pretreatment of platelets with TPO dramatically augmented the thrombin-induced ERK activation, which was almost completely inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	thrombopoietin	Homo sapiens	31-34
11376875-9	2001	Pretreatment of platelets with TPO dramatically augmented the thrombin-induced ERK activation, which was almost completely inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	coagulation factor II, thrombin	Homo sapiens	62-70
11376875-9	2001	Pretreatment of platelets with TPO dramatically augmented the thrombin-induced ERK activation, which was almost completely inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	mitogen-activated protein kinase 1	Homo sapiens	79-82
11306697-4	2001	The PI3K inhibitors wortmannin and LY294002 stimulated stress-activated protein kinase/c-Jun NH(2)-terminal kinase (SAPK/JNK) and p38 mitogen-activated protein kinase (MAPK) phosphorylation in a rapid and concentration-dependent manner that paralleled the inhibition of protein kinase B (PKB) phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	mitogen activated protein kinase 14	Rattus norvegicus	130-166
11306679-6	2001	Zn(2+) also induced stimulation of phosphoinositide 3-kinase (PI3K) The Zn(2+)-induced JNK stimulation was blocked by LY294002, a PI3K inhibitor, or by a dominant-negative mutant of PI3Kgamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	mitogen-activated protein kinase 8	Homo sapiens	87-90
11306698-5	2001	Activities of PI3-kinase and Akt were increased 10 min through 6 h after t-BHQ treatment, whereas wortmannin or LY294002, PI3-kinase inhibitors, completely abolished ARE binding activity and increases in rGSTA2 mRNA and protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	glutathione S-transferase alpha 2	Rattus norvegicus	204-210
11306679-6	2001	Zn(2+) also induced stimulation of phosphoinositide 3-kinase (PI3K) The Zn(2+)-induced JNK stimulation was blocked by LY294002, a PI3K inhibitor, or by a dominant-negative mutant of PI3Kgamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	182-191
11278812-7	2001	Ly294002, a dominant-negative PI-3K construct, and kinase-dead Akt block IFN-promoted cell survival, enhancing apoptotic cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interferon alpha 1	Homo sapiens	73-76
11336793-6	2001	The phosphatidylinositol 3-kinase (PI3 kinase) inhibitors wortmannin and LY294002 only prevented the early ERK2 phosphorylation triggered by FGF2-FGFR4 but not by FGF1-FGFR4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	mitogen-activated protein kinase 1 S homeolog	Xenopus laevis	107-111
11322783-6	2001	Pretreatment of VSMC with a phosphoinositide-3kinase (PI-3K) inhibitor, LY294002, led to significant inhibition of growth factor(s)-induced increases in Akt-3 activity and DNA synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	28-52
11322783-6	2001	Pretreatment of VSMC with a phosphoinositide-3kinase (PI-3K) inhibitor, LY294002, led to significant inhibition of growth factor(s)-induced increases in Akt-3 activity and DNA synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	AKT serine/threonine kinase 3	Homo sapiens	153-158
11336793-6	2001	The phosphatidylinositol 3-kinase (PI3 kinase) inhibitors wortmannin and LY294002 only prevented the early ERK2 phosphorylation triggered by FGF2-FGFR4 but not by FGF1-FGFR4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	fibroblast growth factor 2 L homeolog	Xenopus laevis	141-145
11336793-6	2001	The phosphatidylinositol 3-kinase (PI3 kinase) inhibitors wortmannin and LY294002 only prevented the early ERK2 phosphorylation triggered by FGF2-FGFR4 but not by FGF1-FGFR4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	fibroblast growth factor receptor 4 S homeolog	Xenopus laevis	146-151
11124266-6	2001	Similarly, inhibition of the DAF-16/14-3-3 association by exposure of cells to the PI 3-kinase inhibitor LY294002, enhances DAF-16 DNA binding and transcription activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	29-35
11124266-6	2001	Similarly, inhibition of the DAF-16/14-3-3 association by exposure of cells to the PI 3-kinase inhibitor LY294002, enhances DAF-16 DNA binding and transcription activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	124-130
11124266-7	2001	Surprisingly constitutively nuclear DAF-16 mutants that lack AKT/14-3-3 binding sites also show enhanced DNA binding and transcription activity in response to LY294002, pointing to a 14-3-3-independent mode of regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	36-42
11336793-6	2001	The phosphatidylinositol 3-kinase (PI3 kinase) inhibitors wortmannin and LY294002 only prevented the early ERK2 phosphorylation triggered by FGF2-FGFR4 but not by FGF1-FGFR4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	fibroblast growth factor receptor 4 S homeolog	Xenopus laevis	168-173
11124266-7	2001	Surprisingly constitutively nuclear DAF-16 mutants that lack AKT/14-3-3 binding sites also show enhanced DNA binding and transcription activity in response to LY294002, pointing to a 14-3-3-independent mode of regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	AKT serine/threonine kinase 1	Homo sapiens	61-64
11306613-4	2001	The neuroprotective effect was blocked by the estrogen antagonists ICI 182,780 and tamoxifen and the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	101-130
11278970-4	2001	Wortmannin, LY 294002, or the tyrosine kinase inhibitor genistein abolished the effect of UCP3 on glucose uptake, and wortmannin inhibited UCP3-induced GLUT4 cell surface recruitment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-21	uncoupling protein 3	Homo sapiens	90-94
11294389-1	2001	Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of hsp90 and thereby creating selective inhibitors of PI3K and PI3K-related family.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	heat shock protein 90 alpha family class A member 1	Homo sapiens	114-119
11278284-3	2001	Inhibition of PI 3-kinase using wortmannin and LY-294002 suppressed constitutive Akt activity and sensitized LNCaP cells to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-56	peptidase inhibitor 3	Homo sapiens	14-18
11278284-3	2001	Inhibition of PI 3-kinase using wortmannin and LY-294002 suppressed constitutive Akt activity and sensitized LNCaP cells to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-56	AKT serine/threonine kinase 1	Homo sapiens	81-84
11278284-3	2001	Inhibition of PI 3-kinase using wortmannin and LY-294002 suppressed constitutive Akt activity and sensitized LNCaP cells to TRAIL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-56	TNF superfamily member 10	Homo sapiens	124-129
11245599-7	2001	Loss of sensitivity to apoptotic stimulation is recovered by inhibition of the phosphatidylinositol 3-kinase pathway using LY-294002, suggesting a possible mechanism for the sensitizing effect of caveolin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-132	caveolin 1	Homo sapiens	196-206
11313939-10	2001	In contrast, inhibition of apoptosis by IGF-1 in DiFi cells was sensitive only to LY294002 and not to PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	insulin like growth factor 1	Homo sapiens	40-45
11259253-5	2001	Similar to apo E, apoptogenic agents such as ceramide and LY 294002, a phosphatidylinositol (PI) 3-kinase inhibitor, induced apoptosis and suppressed androstenedione production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-67	apolipoprotein E	Rattus norvegicus	11-16
11259256-4	2001	In contrast, LY294002 almost completely inhibited the activation of MAP kinase, p34(cdc2) kinase activity, and meiotic progression to the MII stage in oocytes surrounded with cumulus cells throughout the treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cyclin dependent kinase 1	Sus scrofa	84-88
11259256-5	2001	Treating cumulus oocyte complexes (COCs) with LY294002 produced a significant decrease in the phosphorylation of connexin-43, a gap junctional protein, in cumulus cells compared with that in COCs cultured without LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	gap junction protein alpha 1	Sus scrofa	113-124
11274962-9	2001	Furthermore, the effects of morphine on SIN-1-induced cytotoxicity were prohibited by pretreatment with the G(i) protein inhibitor, pertussis toxin, and the phosphatidylinositol 3-kinase (PI3 kinase) inhibitors, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	227-235	MAPK associated protein 1	Homo sapiens	40-45
11444439-6	2001	However, inhibition of either MAPK/ERK kinase with PD98059 or PI-3 kinase with LY294002 successfully inhibited progesterone"s actions on ERK and Akt, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	thymoma viral proto-oncogene 1	Mus musculus	145-148
11247849-9	2001	Similarly, use of the PI3 kinase inhibitor LY-294002 also inhibited IGF-I-stimulated DNA synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-52	insulin-like growth factor 1	Danio rerio	68-73
11247802-4	2001	Akt/PKB activation by TNF-alpha was inhibited by a PI3-kinase-specific inhibitor LY-294002 and adenovirus-mediated expression of a dominant negative mutant of PI3-kinase, indicating that TNF-alpha activates Akt/PKB through PI3-kinase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-90	AKT serine/threonine kinase 1	Rattus norvegicus	0-3
11247802-4	2001	Akt/PKB activation by TNF-alpha was inhibited by a PI3-kinase-specific inhibitor LY-294002 and adenovirus-mediated expression of a dominant negative mutant of PI3-kinase, indicating that TNF-alpha activates Akt/PKB through PI3-kinase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-90	AKT serine/threonine kinase 1	Rattus norvegicus	4-7
11247802-4	2001	Akt/PKB activation by TNF-alpha was inhibited by a PI3-kinase-specific inhibitor LY-294002 and adenovirus-mediated expression of a dominant negative mutant of PI3-kinase, indicating that TNF-alpha activates Akt/PKB through PI3-kinase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-90	tumor necrosis factor	Rattus norvegicus	22-31
11247802-4	2001	Akt/PKB activation by TNF-alpha was inhibited by a PI3-kinase-specific inhibitor LY-294002 and adenovirus-mediated expression of a dominant negative mutant of PI3-kinase, indicating that TNF-alpha activates Akt/PKB through PI3-kinase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-90	tumor necrosis factor	Rattus norvegicus	187-196
11247802-4	2001	Akt/PKB activation by TNF-alpha was inhibited by a PI3-kinase-specific inhibitor LY-294002 and adenovirus-mediated expression of a dominant negative mutant of PI3-kinase, indicating that TNF-alpha activates Akt/PKB through PI3-kinase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-90	AKT serine/threonine kinase 1	Rattus norvegicus	211-214
11247802-5	2001	Furthermore, TNF-alpha-induced protein synthesis was inhibited by pretreatment with LY-294002 and expression of a dominant negative mutant of PI3-kinase or Akt/PKB.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-93	tumor necrosis factor	Rattus norvegicus	13-22
11444439-6	2001	However, inhibition of either MAPK/ERK kinase with PD98059 or PI-3 kinase with LY294002 successfully inhibited progesterone"s actions on ERK and Akt, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	mitogen-activated protein kinase 1	Mus musculus	137-140
11328375-4	2001	The increase in translation of TNF-alpha due to serum could be inhibited by the phosphatidylinositol (PI) 3-K inhibitors, wortmannin and LY294002, suggesting that PI 3-K is involved in the translational control of TNF-alpha by serum.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	tumor necrosis factor	Homo sapiens	31-40
11266376-9	2001	An alternative PI 3-kinase inhibitor, LY294002, caused up-regulation of induced COX-2 messenger RNA (mRNA) in HT-29 cells at concentrations of &lt; or =1 micromol/L.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
11328375-4	2001	The increase in translation of TNF-alpha due to serum could be inhibited by the phosphatidylinositol (PI) 3-K inhibitors, wortmannin and LY294002, suggesting that PI 3-K is involved in the translational control of TNF-alpha by serum.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	peptidase inhibitor 3	Homo sapiens	163-167
11357881-5	2001	Cyclosporine A, herbimycin A, LY294002, calphostin C and PD98059 all inhibited anti-Thy-1-induced T lymphocyte proliferation, indicating the involvement of calcineurin, protein tyrosine kinases, phosphatidylinositol 3-kinase, protein kinase C, and MEK1 (MAPK kinase 1), respectively, in Thy-1 signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	thymus cell antigen 1, theta	Mus musculus	84-89
11328375-4	2001	The increase in translation of TNF-alpha due to serum could be inhibited by the phosphatidylinositol (PI) 3-K inhibitors, wortmannin and LY294002, suggesting that PI 3-K is involved in the translational control of TNF-alpha by serum.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	tumor necrosis factor	Homo sapiens	214-223
11282033-5	2001	We found that integrins activated both NF-kappaB and MAPK in a PI 3-K-dependent manner, as wortmannin and LY294002 blocked these responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	nuclear factor kappa B subunit 1	Homo sapiens	39-48
11241354-10	2001	Insulin rescued serum-deprived cells from apoptosis in an AKT-dependent manner, as demonstrated by the inhibition of AKT-activity by the use of LY294002 and ML-9, meanwhile neither inhibition of p70S6-kinase, nor MAPK affected insulin-induced survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	thymoma viral proto-oncogene 1	Mus musculus	58-61
11259600-5	2001	Treatment of wild-type cells with a PI 3-kinase inhibitor, LY294002, markedly decreases the expression of C/EBPalpha and PPARgamma, a result which is associated with a complete block of adipocyte differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	peroxisome proliferator-activated receptor gamma	Cricetulus griseus	121-130
11241354-10	2001	Insulin rescued serum-deprived cells from apoptosis in an AKT-dependent manner, as demonstrated by the inhibition of AKT-activity by the use of LY294002 and ML-9, meanwhile neither inhibition of p70S6-kinase, nor MAPK affected insulin-induced survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	thymoma viral proto-oncogene 1	Mus musculus	117-120
11254732-7	2001	We found that both of these events were linked to PI 3-kinase because the PI 3-kinase inhibitors, wortmannin and LY294002, inhibited LPS-induced phosphorylation of both AKT and GSK-3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	AKT serine/threonine kinase 1	Homo sapiens	169-172
11139588-8	2001	In addition, LY294002, a specific inhibitor of the PI 3-kinase/AKT pathway, reduced phosphorylation of ERalpha in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	AKT serine/threonine kinase 1	Homo sapiens	63-66
11349832-3	2001	The phosphoinositol (OH) 3 kinase inhibitors, Wortmannin (WM) and Ly294002 (LY), block the ability of insulin/IGF-1 to reduce p27 expression, to induce expression of cyclins E, D1, and A as well as cdk 2 and 4, and to phosphorylate retinoblastoma protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	insulin-like growth factor 1	Rattus norvegicus	110-115
11349832-3	2001	The phosphoinositol (OH) 3 kinase inhibitors, Wortmannin (WM) and Ly294002 (LY), block the ability of insulin/IGF-1 to reduce p27 expression, to induce expression of cyclins E, D1, and A as well as cdk 2 and 4, and to phosphorylate retinoblastoma protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	126-129
11349832-3	2001	The phosphoinositol (OH) 3 kinase inhibitors, Wortmannin (WM) and Ly294002 (LY), block the ability of insulin/IGF-1 to reduce p27 expression, to induce expression of cyclins E, D1, and A as well as cdk 2 and 4, and to phosphorylate retinoblastoma protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	cyclin dependent kinase 2	Rattus norvegicus	198-209
11139588-8	2001	In addition, LY294002, a specific inhibitor of the PI 3-kinase/AKT pathway, reduced phosphorylation of ERalpha in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	estrogen receptor 1	Homo sapiens	103-110
11241670-9	2001	Akt activation by PDGF-BB was inhibited by PI 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	AKT serine/threonine kinase 1	Homo sapiens	0-3
11241670-11	2001	Epidermal growth factor (EGF) also activated Akt in osteoblastic cells which was inhibited by LY294002 but not by rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	epidermal growth factor	Homo sapiens	0-23
11241670-11	2001	Epidermal growth factor (EGF) also activated Akt in osteoblastic cells which was inhibited by LY294002 but not by rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	epidermal growth factor	Homo sapiens	25-28
11241670-11	2001	Epidermal growth factor (EGF) also activated Akt in osteoblastic cells which was inhibited by LY294002 but not by rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	AKT serine/threonine kinase 1	Homo sapiens	45-48
11145953-7	2001	In contrast, disruption of the PI 3-kinase pathway with the specific inhibitor LY294002 reduced Akt (protein kinase B) phosphorylation and the levels of FLIP protein and mRNA in all cell lines evaluated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	96-99
11289152-8	2001	Thus, proapoptotic signals induced by both TNF-alpha and LY294002 converge on mitochondria and trigger cytochrome c release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	cytochrome c, somatic	Homo sapiens	103-115
11289152-9	2001	Because EGF can inhibit cytochrome c release induced by LY294002 but not cytochrome c release induced by TNF-alpha, we suggest that the EGF survival mechanism operates on the mitochondrial pathway at a site upstream of cytochrome c release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	cytochrome c, somatic	Homo sapiens	24-36
11237744-5	2001	RSK activity was reduced by PI3 kinase inhibitor LY294002 or MEK1 inhibitor PD98059, suggesting that the ERK as well as the PI3 kinase pathways are involved in regulation of RSK activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	ribosomal protein S6 kinase A2	Homo sapiens	0-3
11237744-5	2001	RSK activity was reduced by PI3 kinase inhibitor LY294002 or MEK1 inhibitor PD98059, suggesting that the ERK as well as the PI3 kinase pathways are involved in regulation of RSK activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mitogen-activated protein kinase 1	Homo sapiens	105-108
11237744-5	2001	RSK activity was reduced by PI3 kinase inhibitor LY294002 or MEK1 inhibitor PD98059, suggesting that the ERK as well as the PI3 kinase pathways are involved in regulation of RSK activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	ribosomal protein S6 kinase A2	Homo sapiens	174-177
11116148-5	2001	The ability of insulin to suppress promoter activity via a C/EBP-binding site is blocked by LY294002, a phosphatidylinositol 3-kinase inhibitor, but not by rapamycin, which blocks activation of p70(S6 kinase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	insulin	Homo sapiens	15-22
11241584-9	2001	The PI 3-kinase inhibitor, LY294002 attenuated neurite growth evoked by NGF, IGF and EGF in dissociated cultures, although the MAP kinase kinase (MEK) inhibitor PD098059 diminished the growth in only IGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	nerve growth factor	Rattus norvegicus	72-75
11241584-9	2001	The PI 3-kinase inhibitor, LY294002 attenuated neurite growth evoked by NGF, IGF and EGF in dissociated cultures, although the MAP kinase kinase (MEK) inhibitor PD098059 diminished the growth in only IGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	epidermal growth factor	Rattus norvegicus	85-88
11280739-13	2001	In the presence of the PI 3-K inhibitor (LY294002), XIAP overexpression failed to block cisplatin-induced apoptosis and to induce Akt phosphorylation, suggesting that the site of action of XIAP is upstream of Akt in this cell survival pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	X-linked inhibitor of apoptosis	Homo sapiens	52-56
11280739-13	2001	In the presence of the PI 3-K inhibitor (LY294002), XIAP overexpression failed to block cisplatin-induced apoptosis and to induce Akt phosphorylation, suggesting that the site of action of XIAP is upstream of Akt in this cell survival pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	X-linked inhibitor of apoptosis	Homo sapiens	189-193
11280786-7	2001	The PI3K inhibitors wortmannin and LY294002 induced apoptosis in NPM/ALK+ cells but exerted only minor effects on the control BaF3 parental cells and peripheral blood mononuclear cells stimulated by growth factors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	nucleophosmin 1	Mus musculus	65-68
11223915-7	2001	Moreover, the caspase-3-like activity is increased by addition of MPTP or MPTP with NGF and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	caspase-3-like	Rattus norvegicus	14-28
11280786-7	2001	The PI3K inhibitors wortmannin and LY294002 induced apoptosis in NPM/ALK+ cells but exerted only minor effects on the control BaF3 parental cells and peripheral blood mononuclear cells stimulated by growth factors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	anaplastic lymphoma kinase	Mus musculus	69-72
11230741-6	2001	Hepatocyte growth factor cytoprotection was prevented by pretreatment with the phosphoinositide 3-kinase inhibitors, wortmannin (50 nmol/L) or Ly 294002 (40 micromol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-152	hepatocyte growth factor	Rattus norvegicus	0-24
11367542-6	2001	In this context, pretreatment of LY294002, but not SB203580, inhibited IL-1-induced NF-kappa B activation significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	interleukin 1 alpha	Homo sapiens	71-75
11367542-6	2001	In this context, pretreatment of LY294002, but not SB203580, inhibited IL-1-induced NF-kappa B activation significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	nuclear factor kappa B subunit 1	Homo sapiens	84-94
11367542-7	2001	While IL-1 induced-AP-1 activation was moderate, both LY294002 and SB203580 suppressed IL-1-induced AP-1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	interleukin 1 alpha	Homo sapiens	87-91
11367542-9	2001	Namely, LY294002 inhibited TRAF6-mediated IL-1-induced NF-kappa B and AP-1 activation markedly, while SB203580 inhibited TRAF6-induced AP-1 activation but not NF-kappa B activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	TNF receptor associated factor 6	Homo sapiens	27-32
11367542-9	2001	Namely, LY294002 inhibited TRAF6-mediated IL-1-induced NF-kappa B and AP-1 activation markedly, while SB203580 inhibited TRAF6-induced AP-1 activation but not NF-kappa B activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	interleukin 1 alpha	Homo sapiens	42-46
11367542-9	2001	Namely, LY294002 inhibited TRAF6-mediated IL-1-induced NF-kappa B and AP-1 activation markedly, while SB203580 inhibited TRAF6-induced AP-1 activation but not NF-kappa B activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	nuclear factor kappa B subunit 1	Homo sapiens	55-65
11238738-3	2001	The phosphoinositide 3-kinase (PI 3-kinase) inhibitor, LY294002, reversed this inhibition suggesting that Trk A activation of PI 3-kinase is necessary to inhibit sphingolipid signaling by p75(NTR).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	106-111
11238738-3	2001	The phosphoinositide 3-kinase (PI 3-kinase) inhibitor, LY294002, reversed this inhibition suggesting that Trk A activation of PI 3-kinase is necessary to inhibit sphingolipid signaling by p75(NTR).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	nerve growth factor receptor	Rattus norvegicus	188-191
11181517-11	2001	Induction of IRBP was blunted by the phosphatidylinositol 3"-kinase inhibitor LY294002, whereas other signal transduction inhibitors had little effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	retinol binding protein 3	Rattus norvegicus	13-17
11222636-6	2001	Moreover, Src appeared to promote neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway because the PI-3K inhibitor LY294002 prevented GFL-mediated neuronal survival and prevented activated Src-mediated neuronal survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	10-13
11222636-6	2001	Moreover, Src appeared to promote neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway because the PI-3K inhibitor LY294002 prevented GFL-mediated neuronal survival and prevented activated Src-mediated neuronal survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	216-219
11226388-12	2001	In contrast, wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), inhibitors of phosphatidylinositol 3-kinase, attenuated adenosine A(1) receptor stimulation of p42/p44 MAPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-37	cyclin dependent kinase 20	Homo sapiens	185-188
11179453-6	2001	Angiotensin II-induced AT(1) receptor phosphorylation was partially blocked by the protein kinase C inhibitor bisindolylmaleimide I and by phosphoinositide 3-kinase inhibitors (wortmannin and LY294002); the actions of these inhibitors were not additive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	192-200	angiotensinogen	Rattus norvegicus	0-14
11226388-12	2001	In contrast, wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), inhibitors of phosphatidylinositol 3-kinase, attenuated adenosine A(1) receptor stimulation of p42/p44 MAPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-37	interferon induced protein 44	Homo sapiens	189-192
11226388-12	2001	In contrast, wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), inhibitors of phosphatidylinositol 3-kinase, attenuated adenosine A(1) receptor stimulation of p42/p44 MAPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-37	adenosine A1 receptor	Homo sapiens	146-169
11226388-12	2001	In contrast, wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), inhibitors of phosphatidylinositol 3-kinase, attenuated adenosine A(1) receptor stimulation of p42/p44 MAPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-37	mitogen-activated protein kinase 3	Homo sapiens	193-197
11226388-12	2001	In contrast, wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), inhibitors of phosphatidylinositol 3-kinase, attenuated adenosine A(1) receptor stimulation of p42/p44 MAPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-87	adenosine A1 receptor	Homo sapiens	146-169
11226388-12	2001	In contrast, wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), inhibitors of phosphatidylinositol 3-kinase, attenuated adenosine A(1) receptor stimulation of p42/p44 MAPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-87	cyclin dependent kinase 20	Homo sapiens	185-188
11226388-12	2001	In contrast, wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), inhibitors of phosphatidylinositol 3-kinase, attenuated adenosine A(1) receptor stimulation of p42/p44 MAPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-87	interferon induced protein 44	Homo sapiens	189-192
11226388-12	2001	In contrast, wortmannin and LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), inhibitors of phosphatidylinositol 3-kinase, attenuated adenosine A(1) receptor stimulation of p42/p44 MAPK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-87	mitogen-activated protein kinase 3	Homo sapiens	193-197
11164909-6	2001	In other experiments, PRL was shown to rapidly activate a downstream effector of PI3-kinase, Akt, and this effect was also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	prolactin	Rattus norvegicus	22-25
11230338-11	2001	In contrast to DNA synthesis, wortmannin and LY-294002 markedly attenuated the decrease in caspase-3 activity mediated by rHGF, whereas PD98059 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-54	caspase 3	Homo sapiens	91-100
11164909-6	2001	In other experiments, PRL was shown to rapidly activate a downstream effector of PI3-kinase, Akt, and this effect was also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
11245436-6	2001	Phosphatidylinositol 3-kinase, mitogen-activated protein kinase kinase, and p70 kinase were inhibited with LY294002, PD98059, and rapamycin, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	ubiquitin associated and SH3 domain containing B	Homo sapiens	76-79
11245436-7	2001	Induction of uPA protein by IGF-I was partially inhibited by LY294002 (60% inhibition) or PD98059 (30% inhibition) but not by rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	plasminogen activator, urokinase	Homo sapiens	13-16
11245436-7	2001	Induction of uPA protein by IGF-I was partially inhibited by LY294002 (60% inhibition) or PD98059 (30% inhibition) but not by rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	insulin like growth factor 1	Homo sapiens	28-33
11245436-11	2001	Both LY294002 and PD98059 were required to completely inhibit uPA mRNA expression, whereas each drug alone resulted in approximately 50% reduction in uPA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	plasminogen activator, urokinase	Homo sapiens	62-65
11245436-13	2001	Furthermore, both Ly294002 and PD98059 were necessary to block IGF-I-stimulated uPA-Luc activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	insulin like growth factor 1	Homo sapiens	63-68
11245436-13	2001	Furthermore, both Ly294002 and PD98059 were necessary to block IGF-I-stimulated uPA-Luc activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	plasminogen activator, urokinase	Homo sapiens	80-83
11314001-9	2001	However, the IL-6-induced Mcl-1 up-regulation was effectively attenuated in the presence of PI 3-K inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	interleukin 6	Homo sapiens	13-17
11314001-9	2001	However, the IL-6-induced Mcl-1 up-regulation was effectively attenuated in the presence of PI 3-K inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	26-31
11341977-4	2001	As expected, phosphorylation of protein kinase B/akt was blocked by the phosphoinositide 3-kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	AKT serine/threonine kinase 1	Homo sapiens	49-52
11208554-9	2001	G17 induction of Akt phosphorylation was inhibited by the phosphoinositide 3-kinase (PI 3-kinase) inhibitors LY-294002 (10 microM) and wortmannin (200 nM) but not by the mitogen-activated protein kinase kinase 1 inhibitor PD-98059 (50 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-118	AKT serine/threonine kinase 1	Rattus norvegicus	17-20
11157484-2	2001	Here, we present evidence that both proteins undergo PI 3-kinase-dependent translocation to the plasma membrane on CRP stimulation that is markedly inhibited by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	53-57
11157484-2	2001	Here, we present evidence that both proteins undergo PI 3-kinase-dependent translocation to the plasma membrane on CRP stimulation that is markedly inhibited by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	C-reactive protein, pentraxin-related	Mus musculus	115-118
11230338-11	2001	In contrast to DNA synthesis, wortmannin and LY-294002 markedly attenuated the decrease in caspase-3 activity mediated by rHGF, whereas PD98059 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-54	hepatocyte growth factor	Rattus norvegicus	122-126
11273003-6	2001	LY294002, a phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor, blocks the effect of IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 1	Homo sapiens	88-93
11158266-8	2001	LY294002, a phosphatidylinositol-3 kinase inhibitor, blocked insulin-like growth factor-I inhibition on JNK activation, suggesting that phosphatidylinositol-3 kinase mediates the effects of insulin-like growth factor-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 1	Homo sapiens	61-89
11158266-8	2001	LY294002, a phosphatidylinositol-3 kinase inhibitor, blocked insulin-like growth factor-I inhibition on JNK activation, suggesting that phosphatidylinositol-3 kinase mediates the effects of insulin-like growth factor-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 8	Homo sapiens	104-107
11158266-8	2001	LY294002, a phosphatidylinositol-3 kinase inhibitor, blocked insulin-like growth factor-I inhibition on JNK activation, suggesting that phosphatidylinositol-3 kinase mediates the effects of insulin-like growth factor-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 1	Homo sapiens	190-218
11134526-7	2001	HGF-induced survival correlates with Akt activity and is inhibited by the specific PI3-kinase inhibitor LY294002, indicating that HGF inhibits cell death through the PI3-kinase/Akt signal transduction pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	hepatocyte growth factor	Homo sapiens	0-3
11400324-8	2001	pretreatment with LY294002, indicating that morphine can activate PLC gamma 1 through the stimulation of PI3-Kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	phospholipase C, gamma 1	Mus musculus	66-77
11228094-5	2001	The antiapoptotic effect of IGF-1 was blocked by LY294002 (an inhibitor of phosphatidylinositol 3-kinase) and by PD98059 (an inhibitor of extracellular signal-regulated kinase (ERK)).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	insulin-like growth factor 1	Rattus norvegicus	28-33
11134526-7	2001	HGF-induced survival correlates with Akt activity and is inhibited by the specific PI3-kinase inhibitor LY294002, indicating that HGF inhibits cell death through the PI3-kinase/Akt signal transduction pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	hepatocyte growth factor	Homo sapiens	130-133
11134526-7	2001	HGF-induced survival correlates with Akt activity and is inhibited by the specific PI3-kinase inhibitor LY294002, indicating that HGF inhibits cell death through the PI3-kinase/Akt signal transduction pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	AKT serine/threonine kinase 2	Homo sapiens	177-180
11145583-4	2001	The protective effect of IGF-1 was blocked by phosphoinositide 3-kinase (PI3K) inhibitors, wortmannin, and LY294002, but was unaffected by rapamycin, PD98059, or SB203580, which inhibit mammalian target of rapamycin (mTOR), ERK kinase (MEK1), and p38 MAPK respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	insulin like growth factor 1	Homo sapiens	25-30
11252727-3	2001	Moreover, inhibition of total PI3K activity by wortmannin or LY294002 significantly enlarges EGFR-containing endosomes and dissociates the early-endosomal autoantigen EEA1 from membrane fractions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	epidermal growth factor receptor	Homo sapiens	93-97
11252727-3	2001	Moreover, inhibition of total PI3K activity by wortmannin or LY294002 significantly enlarges EGFR-containing endosomes and dissociates the early-endosomal autoantigen EEA1 from membrane fractions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	early endosome antigen 1	Homo sapiens	167-171
11145577-6	2001	The presence of the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor Ly 294002 abolished proliferation induced by GH, arresting Ba/F3 GHR cells at the G(1)/S boundary, but did not promote apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-83	growth hormone receptor	Mus musculus	139-142
11145577-8	2001	Addition of Ly 294002 resulted in a moderate decrease in NF-kappaB activation by GH, suggesting a possible link between PI 3-kinase and NF-kappaB signaling by GH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
11145583-6	2001	When added to the combination of IGF-1 and LY294002, PI(3,4,5)P3 reversed most of the inhibitory effect of LY294002 on IGF-1-dependent cell survival, protein kinase B/Akt phosphorylation, and caspase-3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	insulin like growth factor 1	Homo sapiens	33-38
11145577-8	2001	Addition of Ly 294002 resulted in a moderate decrease in NF-kappaB activation by GH, suggesting a possible link between PI 3-kinase and NF-kappaB signaling by GH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-145
11145583-6	2001	When added to the combination of IGF-1 and LY294002, PI(3,4,5)P3 reversed most of the inhibitory effect of LY294002 on IGF-1-dependent cell survival, protein kinase B/Akt phosphorylation, and caspase-3 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	insulin like growth factor 1	Homo sapiens	119-124
11099491-3	2001	In cell-based screens we detected a significant reduction in Abeta concentration after treatment with the phosphatidylinositol kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	amyloid beta (A4) precursor protein	Mus musculus	61-66
11145615-1	2001	The phosphoinositide 3-kinase (PI3K) inhibitors, LY294002 (LY) and wortmannin (WM), are widely used to examine the role of PI3K in growth factor signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-51	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-29
11145615-0	2001	Growth factor-stimulated phosphorylation of Akt and p70(S6K) is differentially inhibited by LY294002 and Wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	AKT serine/threonine kinase 1	Homo sapiens	44-47
11145615-0	2001	Growth factor-stimulated phosphorylation of Akt and p70(S6K) is differentially inhibited by LY294002 and Wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	ribosomal protein S6 kinase B1	Homo sapiens	52-55
11145615-1	2001	The phosphoinositide 3-kinase (PI3K) inhibitors, LY294002 (LY) and wortmannin (WM), are widely used to examine the role of PI3K in growth factor signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	4-29
11145615-6	2001	LY is much less effective in blocking the phosphorylation of Akt than p70(S6K); at concentrations which completely inhibit phosphorylation of p70(S6K), phosphorylation of Akt is only partially inhibited by LY.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-2	AKT serine/threonine kinase 1	Homo sapiens	61-64
11160134-6	2001	Experiments in 3T3-L1 preadipocytes and adipocytes revealed that insulin-stimulated phosphorylation of Ser307 was inhibited by LY294002 or wortmannin, whereas TNF-alpha-stimulated phosphorylation was inhibited by PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	insulin	Homo sapiens	65-72
11145615-6	2001	LY is much less effective in blocking the phosphorylation of Akt than p70(S6K); at concentrations which completely inhibit phosphorylation of p70(S6K), phosphorylation of Akt is only partially inhibited by LY.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-2	ubiquitin associated and SH3 domain containing B	Homo sapiens	142-145
11145615-6	2001	LY is much less effective in blocking the phosphorylation of Akt than p70(S6K); at concentrations which completely inhibit phosphorylation of p70(S6K), phosphorylation of Akt is only partially inhibited by LY.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-2	AKT serine/threonine kinase 1	Homo sapiens	171-174
11145615-6	2001	LY is much less effective in blocking the phosphorylation of Akt than p70(S6K); at concentrations which completely inhibit phosphorylation of p70(S6K), phosphorylation of Akt is only partially inhibited by LY.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	206-208	AKT serine/threonine kinase 1	Homo sapiens	171-174
11549843-5	2001	Two phosphatidylinositol (PI) 3-kinase-specific inhibitors, wortmannin and LY294002, inhibited IL-1 beta-induced synthesis of PKC-epsilon.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	interleukin 1 beta	Mus musculus	95-104
11549843-5	2001	Two phosphatidylinositol (PI) 3-kinase-specific inhibitors, wortmannin and LY294002, inhibited IL-1 beta-induced synthesis of PKC-epsilon.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	protein kinase C, epsilon	Mus musculus	126-137
11255225-5	2001	The VEGF synthesis by BMP-4 was suppressed by wortmannin and LY294002, inhibitors of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	vascular endothelial growth factor A	Mus musculus	4-8
11255225-5	2001	The VEGF synthesis by BMP-4 was suppressed by wortmannin and LY294002, inhibitors of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	bone morphogenetic protein 4	Mus musculus	22-27
11255225-6	2001	Both wortmannin and LY294002 inhibited the BMP-4-stimulated phosphorylation of p70 S6 kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	bone morphogenetic protein 4	Mus musculus	43-48
11208901-4	2001	The effect of TGZ on motoneurones was additive to that of insulin-like growth factor-I and both activities were inhibited by phosphatidylinositol 3-kinase (PI3-kinase) inhibitors, wortmannin and LY294002, suggesting the involvement of the activation of PI3-kinase in the activity of TGZ.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	insulin-like growth factor 1	Rattus norvegicus	58-86
11384880-9	2001	The inhibition of IL-4-induced 3beta-HSD expression by PI 3-kinase inhibitors (wortmannin and LY294002) as well as an inhibitor of MAP kinase activation (PD98059), indicates the involvement of those pathways in this response to IL-4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	interleukin 4	Homo sapiens	18-22
11384880-9	2001	The inhibition of IL-4-induced 3beta-HSD expression by PI 3-kinase inhibitors (wortmannin and LY294002) as well as an inhibitor of MAP kinase activation (PD98059), indicates the involvement of those pathways in this response to IL-4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	31-40
11167133-8	2001	The increase in the BH4 level and the induction of GTPCH mRNA by insulin were reduced by wortmannin and LY294002, which are both phosphatidylinositol 3-kinase (PI3-kinase) inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-112	GTP cyclohydrolase 1	Mus musculus	51-56
11147817-6	2001	The use of specific inhibitors of the insulin-signaling pathways indicated that myogenesis was precluded by treatment for 72 h with LY294002 (an inhibitor of PI 3-kinase), rapamycin (a p70S6-kinase blocker), and SB203580 or PD169316 (p38-MAPK inhibitors).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	mitogen-activated protein kinase 14	Mus musculus	234-237
11147817-6	2001	The use of specific inhibitors of the insulin-signaling pathways indicated that myogenesis was precluded by treatment for 72 h with LY294002 (an inhibitor of PI 3-kinase), rapamycin (a p70S6-kinase blocker), and SB203580 or PD169316 (p38-MAPK inhibitors).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	mitogen-activated protein kinase 3	Mus musculus	238-242
11208924-6	2001	Furthermore, confocal laser scanning microscopy demonstrated that inhibition of the PI 3-K activity by LY294002 or wortmannin concomitant with induction of differentiation changes the cellular distribution leading to a pericentrosomal localization of GFAP and an altered cell shape lacking process formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	glial fibrillary acidic protein	Rattus norvegicus	251-255
11162460-5	2000	Pretreatment of cells with the specific PI3 kinase inhibitor LY294002 abolished insulin- or PE-activation of PKB/Akt, suggesting that activation of PKB/Akt is mediated by a PI3 kinase-dependent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	thymoma viral proto-oncogene 1	Mus musculus	152-155
11377858-3	2001	To characterize the involvement of the mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in the biological effect of glial cell line-derived neurotrophic factor, we used the mitogen-activated protein kinase kinase inhibitor PD98059 and the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	306-314	glial cell derived neurotrophic factor	Rattus norvegicus	143-186
11377858-5	2001	LY294002 reversed the survival-promoting effect of glial cell line-derived neurotrophic factor on the PC12-GFRalpha1 cells in serum-deprived medium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glial cell derived neurotrophic factor	Rattus norvegicus	51-94
11162442-5	2000	Treatment with PI3-kinase inhibitors, wortmannin, and LY294002 partly eliminated the UV-mediated inhibition of cell death and recovered the inhibited caspase-3/7 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	caspase 3	Mus musculus	150-159
11162460-5	2000	Pretreatment of cells with the specific PI3 kinase inhibitor LY294002 abolished insulin- or PE-activation of PKB/Akt, suggesting that activation of PKB/Akt is mediated by a PI3 kinase-dependent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	thymoma viral proto-oncogene 1	Mus musculus	109-112
11162460-5	2000	Pretreatment of cells with the specific PI3 kinase inhibitor LY294002 abolished insulin- or PE-activation of PKB/Akt, suggesting that activation of PKB/Akt is mediated by a PI3 kinase-dependent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	thymoma viral proto-oncogene 1	Mus musculus	113-116
11162460-7	2000	Moreover, HGF and insulin were able to attenuate transforming growth factor beta-induced apoptosis in hepatic cells, and these effects were antagonized by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	hepatocyte growth factor	Mus musculus	10-13
11162460-5	2000	Pretreatment of cells with the specific PI3 kinase inhibitor LY294002 abolished insulin- or PE-activation of PKB/Akt, suggesting that activation of PKB/Akt is mediated by a PI3 kinase-dependent mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	thymoma viral proto-oncogene 1	Mus musculus	148-151
10995743-9	2000	Thus, two unrelated structurally distinct specific inhibitors of PI3-K, wortmannin and LY294002, prevent VSMC migration induced by uPA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	plasminogen activator, urokinase	Homo sapiens	131-134
11007772-7	2000	Preincubating cells with PI 3-kinase inhibitor LY294002 was associated with loss of anti-apoptotic actions of IGF-I and PI 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	insulin like growth factor 1	Homo sapiens	110-115
11162904-4	2000	IGF-I induces Akt phosphorylation at Ser473, an event which may be blocked by pretreatment with a PI-3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	insulin like growth factor 1	Homo sapiens	0-5
11162904-4	2000	IGF-I induces Akt phosphorylation at Ser473, an event which may be blocked by pretreatment with a PI-3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	AKT serine/threonine kinase 1	Homo sapiens	14-17
11110685-5	2000	It was also found that though inhibition of phosphatidyl-inositol 3-kinase (PI-3K) by LY294002 in alpha(IIb)beta(3)(+) cells induced apoptosis and inhibited chemotaxis adhesion and the secretion of MMP-9 and VEGF, the inhibition of MAPK p42/44 (by the MEK inhibitor U0126) had no effect on the survival, proliferation, and migration of these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	44-74
11010972-7	2000	The PI3K inhibitor LY-294002 blocks the ability of BCR/ABL to induce p27(Kip1) down-regulation and inhibits BCR/ABL-induced entry into S phase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	51-58
11010972-7	2000	The PI3K inhibitor LY-294002 blocks the ability of BCR/ABL to induce p27(Kip1) down-regulation and inhibits BCR/ABL-induced entry into S phase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	interferon alpha inducible protein 27	Homo sapiens	69-72
11010972-7	2000	The PI3K inhibitor LY-294002 blocks the ability of BCR/ABL to induce p27(Kip1) down-regulation and inhibits BCR/ABL-induced entry into S phase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	cyclin dependent kinase inhibitor 1B	Homo sapiens	73-77
11010972-7	2000	The PI3K inhibitor LY-294002 blocks the ability of BCR/ABL to induce p27(Kip1) down-regulation and inhibits BCR/ABL-induced entry into S phase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	108-115
11110708-5	2000	The use of 2 specific PI 3-kinase inhibitors, wortmannin and LY294002, demonstrated the requirement of PI 3-kinase for the growth of NPM-ALK-transformed cell lines, as well as a cell line established from a patient with ALCL.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	nucleophosmin 1	Homo sapiens	133-136
11110685-5	2000	It was also found that though inhibition of phosphatidyl-inositol 3-kinase (PI-3K) by LY294002 in alpha(IIb)beta(3)(+) cells induced apoptosis and inhibited chemotaxis adhesion and the secretion of MMP-9 and VEGF, the inhibition of MAPK p42/44 (by the MEK inhibitor U0126) had no effect on the survival, proliferation, and migration of these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	matrix metallopeptidase 9	Homo sapiens	198-203
11110685-5	2000	It was also found that though inhibition of phosphatidyl-inositol 3-kinase (PI-3K) by LY294002 in alpha(IIb)beta(3)(+) cells induced apoptosis and inhibited chemotaxis adhesion and the secretion of MMP-9 and VEGF, the inhibition of MAPK p42/44 (by the MEK inhibitor U0126) had no effect on the survival, proliferation, and migration of these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	vascular endothelial growth factor A	Homo sapiens	208-212
11110685-5	2000	It was also found that though inhibition of phosphatidyl-inositol 3-kinase (PI-3K) by LY294002 in alpha(IIb)beta(3)(+) cells induced apoptosis and inhibited chemotaxis adhesion and the secretion of MMP-9 and VEGF, the inhibition of MAPK p42/44 (by the MEK inhibitor U0126) had no effect on the survival, proliferation, and migration of these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	mitogen-activated protein kinase kinase 7	Homo sapiens	252-255
11127822-4	2000	Apoptosis was also observed in the presence of serum growth factors when endogenous PI3K activity was blocked using the synthetic inhibitor LY294002, further suggesting an important role for PI3-K in cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-148	peptidase inhibitor 3	Homo sapiens	84-87
11156376-3	2000	Blocking of the Akt pathway by a dominant-negative Akt or an inhibitor LY294002 abrogates the HER-2/neu-induced AR signaling and cell survival/growth effects in the absence or presence of androgen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Homo sapiens	16-19
11156376-3	2000	Blocking of the Akt pathway by a dominant-negative Akt or an inhibitor LY294002 abrogates the HER-2/neu-induced AR signaling and cell survival/growth effects in the absence or presence of androgen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	94-99
11156376-3	2000	Blocking of the Akt pathway by a dominant-negative Akt or an inhibitor LY294002 abrogates the HER-2/neu-induced AR signaling and cell survival/growth effects in the absence or presence of androgen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-103
11156376-3	2000	Blocking of the Akt pathway by a dominant-negative Akt or an inhibitor LY294002 abrogates the HER-2/neu-induced AR signaling and cell survival/growth effects in the absence or presence of androgen.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	androgen receptor	Homo sapiens	112-114
11118064-6	2000	Inhibition of PI 3-K activity with wortmannin or Ly294002 blocked the antiapoptotic effect of IGF-I and the proliferative effect of IL-6 in the myeloma cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	insulin like growth factor 1	Homo sapiens	94-99
11118064-6	2000	Inhibition of PI 3-K activity with wortmannin or Ly294002 blocked the antiapoptotic effect of IGF-I and the proliferative effect of IL-6 in the myeloma cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	interleukin 6	Homo sapiens	132-136
11152961-4	2000	p38-induced myogenic differentiation can be inhibited by the PI 3-kinase inhibitor LY294002 without affecting p38 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	mitogen-activated protein kinase 14	Homo sapiens	0-3
11108276-7	2000	ET-1 induced 2-DOG uptake and GLUT1 expression at 6 h were completely inhibited by the MEK inhibitor, PD 98059, and partially inhibited by the PI3-kinase inhibitor, LY 294002, and the G alpha i inhibitor, pertussis toxin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-174	endothelin 1	Canis lupus familiaris	0-4
11228049-8	2000	PD98059 inhibited activation of Erk and LY294002 repressed activation of Akt in response to IGF-I, but did not affect tyrosine phosphorylation of the IGF-IR, IRS-1, IRS-2, or Shc.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	73-76
11228049-9	2000	Each PD98059 and LY294002 inhibited IGF-I-dependent cell proliferation in a concentration-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	insulin like growth factor 1	Homo sapiens	36-41
11228049-10	2000	In contrast, each of these inhibitors only partially depressed NPY gene expression induced by IGF-I and slightly inhibited IGF-I-mediated neurite outgrowth; however, when both PD98059 and LY294002 were present, IGF-I-dependent NPY gene expression and neurite outgrowth were abolished completely.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	neuropeptide Y	Homo sapiens	63-66
11228049-10	2000	In contrast, each of these inhibitors only partially depressed NPY gene expression induced by IGF-I and slightly inhibited IGF-I-mediated neurite outgrowth; however, when both PD98059 and LY294002 were present, IGF-I-dependent NPY gene expression and neurite outgrowth were abolished completely.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	insulin like growth factor 1	Homo sapiens	123-128
11228049-10	2000	In contrast, each of these inhibitors only partially depressed NPY gene expression induced by IGF-I and slightly inhibited IGF-I-mediated neurite outgrowth; however, when both PD98059 and LY294002 were present, IGF-I-dependent NPY gene expression and neurite outgrowth were abolished completely.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	insulin like growth factor 1	Homo sapiens	123-128
11228049-10	2000	In contrast, each of these inhibitors only partially depressed NPY gene expression induced by IGF-I and slightly inhibited IGF-I-mediated neurite outgrowth; however, when both PD98059 and LY294002 were present, IGF-I-dependent NPY gene expression and neurite outgrowth were abolished completely.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	neuropeptide Y	Homo sapiens	227-230
11162290-5	2000	Macrophage chemotaxis induced by the combination of CNTFRalpha and CNTF was inhibited in a dose-dependent fashion by wortmannin, LY294002 or PD98059, suggesting the involvement of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	ciliary neurotrophic factor receptor	Homo sapiens	52-62
11162290-5	2000	Macrophage chemotaxis induced by the combination of CNTFRalpha and CNTF was inhibited in a dose-dependent fashion by wortmannin, LY294002 or PD98059, suggesting the involvement of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	ciliary neurotrophic factor	Homo sapiens	52-56
10969078-4	2000	LY294002, an inhibitor of the p110 catalytic subunit of PI3K, and a dominant-negative mutant of Akt blocked the delocalization of ZO-1 induced by TGFbeta1, whereas transfection of constitutively active p110 induced loss of ZO-1 from tight junctions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tight junction protein 1	Mus musculus	130-134
10967119-12	2000	LY294002 also diminished the activation of the L-PK gene caused by inhibition of 5"-AMP-activated protein kinase with anti-5"-AMP-activated protein kinase alpha2 antibodies.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	pyruvate kinase liver and red blood cell	Mus musculus	47-51
10969078-4	2000	LY294002, an inhibitor of the p110 catalytic subunit of PI3K, and a dominant-negative mutant of Akt blocked the delocalization of ZO-1 induced by TGFbeta1, whereas transfection of constitutively active p110 induced loss of ZO-1 from tight junctions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transforming growth factor, beta 1	Mus musculus	146-154
10969078-4	2000	LY294002, an inhibitor of the p110 catalytic subunit of PI3K, and a dominant-negative mutant of Akt blocked the delocalization of ZO-1 induced by TGFbeta1, whereas transfection of constitutively active p110 induced loss of ZO-1 from tight junctions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tight junction protein 1	Mus musculus	223-227
10969078-5	2000	In addition, LY294002 blocked TGFbeta-mediated C-terminal phosphorylation of Smad2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	transforming growth factor, beta 1	Mus musculus	30-37
10969078-5	2000	In addition, LY294002 blocked TGFbeta-mediated C-terminal phosphorylation of Smad2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	SMAD family member 2	Mus musculus	77-82
10969078-6	2000	Consistent with these data, TGFbeta-induced p3TP-Lux and p(CAGA)(12)-Lux reporter activities were inhibited by LY294002 and transiently expressed dominant-negative p85 and Akt mutants in NMuMG and 4T1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	transforming growth factor, beta 1	Mus musculus	28-35
10969078-6	2000	Consistent with these data, TGFbeta-induced p3TP-Lux and p(CAGA)(12)-Lux reporter activities were inhibited by LY294002 and transiently expressed dominant-negative p85 and Akt mutants in NMuMG and 4T1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	59-63
10969078-6	2000	Consistent with these data, TGFbeta-induced p3TP-Lux and p(CAGA)(12)-Lux reporter activities were inhibited by LY294002 and transiently expressed dominant-negative p85 and Akt mutants in NMuMG and 4T1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	extracellular matrix protein 1	Mus musculus	164-167
10969078-6	2000	Consistent with these data, TGFbeta-induced p3TP-Lux and p(CAGA)(12)-Lux reporter activities were inhibited by LY294002 and transiently expressed dominant-negative p85 and Akt mutants in NMuMG and 4T1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	thymoma viral proto-oncogene 1	Mus musculus	172-175
10969078-8	2000	Finally, LY294002 and neutralizing TGFbeta1 antibodies inhibited ligand-independent constitutively active Akt as well as basal and TGFbeta-stimulated migration in 4T1 and EMT6 breast tumor cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	thymoma viral proto-oncogene 1	Mus musculus	106-109
11062076-6	2000	Akt activation is inhibited in the presence of the phosphoinositide 3-kinase (PI-3K) inhibitors wortmannin and LY294002, and by treatment with the platelet-derived growth factor (PDGF) receptor (PDGFR) inhibitor AG1295, indicating a requirement for PDGFR and PI-3K in mediating peroxynitrite-induced Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Homo sapiens	0-3
11103940-9	2000	However, at concentrations of LY294002 where activated forms of Akt, a downstream component of the PI3K pathway, were undetectable, colony and focus forming abilities of the v-Src-RIE cells were only slightly affected whereas those of gag-IR/IGFR-RIE cells were greatly inhibited.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Rattus norvegicus	64-67
11078875-5	2000	Here we show that inhibition of phosphoinositide 3-kinase (PI 3-K) by very low concentrations of wortmannin or LY294002 transformed the irreversible platelet aggregation induced by a combination of NE and low concentrations of CG into a reversible aggregation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	32-57
11029292-4	2000	The phosphatidylinositol 3-kinase (PI 3-K) inhibitors wortmannin (100 nM) and LY-294002 (20 microM) blocked completely the stimulation of HCO(3)(-) absorption by hyposmolality.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-87	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	4-33
10896679-2	2000	Here we show that inhibition of PI3-K activity by the pharmacological agent LY294002 affects early processes of myoblast differentiation including the transcriptional activation of myogenin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	myogenin	Homo sapiens	181-189
10896679-4	2000	We find that expression of a dominant negative form of PI3-K or growth in the presence of LY294002 inhibits cellular activity of MEF2 but not of MyoD.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	myocyte enhancer factor 2A	Homo sapiens	129-133
11053007-6	2000	In contrast, the phosphatidylinositol 3"-kinase (PI 3-K) inhibitor LY-294002 significantly reduced the drop in transepithelial resistance caused by SEB-PBMC-conditioned medium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-76	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	17-47
11042116-2	2000	Wortmannin and LY 294002 completely prevented the insulin-induced increase in glucokinase mRNA seen in unhibited cells, indicating that the phosphoinositide 3-kinase module has a key role.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	glucokinase	Rattus norvegicus	78-89
10940312-5	2000	LY294002, a specific inhibitor of phosphoinositol 3-kinase, also suppressed Epo-induced signal transduction, which could be partially relieved by activators of PKC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	erythropoietin	Homo sapiens	76-79
10940312-5	2000	LY294002, a specific inhibitor of phosphoinositol 3-kinase, also suppressed Epo-induced signal transduction, which could be partially relieved by activators of PKC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein kinase C alpha	Homo sapiens	160-163
11089547-3	2000	In the present study, we demonstrated that wortmannin and LY294002, two specific inhibitors of phosphatidylinositol 3-kinase (PI3-kinase), interfere both in the signaling pathways of insulin and TSH leading to glucose consumption enhancement and Glut-1 translocation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	solute carrier family 2 member 1	Rattus norvegicus	246-252
11095246-3	2000	Inhibition of the mitogen-activated protein kinase pathway by the specific inhibitors PD98059 and U0126 and of phosphatidylinositol 3-kinase by LY294002, strongly inhibited Epo-induced TIMP-1 expression and secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	erythropoietin	Homo sapiens	173-176
11095246-3	2000	Inhibition of the mitogen-activated protein kinase pathway by the specific inhibitors PD98059 and U0126 and of phosphatidylinositol 3-kinase by LY294002, strongly inhibited Epo-induced TIMP-1 expression and secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	144-152	TIMP metallopeptidase inhibitor 1	Homo sapiens	185-191
11095246-6	2000	The addition of PD98059, U0126, and LY294002 in the presence of Epo restored MMP-9 production in UT-7 and CD36+ cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	erythropoietin	Homo sapiens	64-67
11095246-6	2000	The addition of PD98059, U0126, and LY294002 in the presence of Epo restored MMP-9 production in UT-7 and CD36+ cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	matrix metallopeptidase 9	Homo sapiens	77-82
11131301-4	2000	RESULTS: Wortmannin or LY294002 inhibited M-CSF-stimulated increases in BAC1.2F5 cell density.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	colony stimulating factor 1 (macrophage)	Mus musculus	42-47
11089547-5	2000	Wortmannin or LY294002 blocked the insulin, (Bu)2cAMP, and the TSH-induced translocation of Glut-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	solute carrier family 2 member 1	Rattus norvegicus	92-98
11089547-7	2000	These results suggest that in FRTL-5 cells wortmannin and LY294002 inhibited the insulin, (Bu)2cAMP and TSH events leading to Glut-1 translocation from an intracellular compartment to the plasma membrane.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	solute carrier family 2 member 1	Rattus norvegicus	126-132
11042022-3	2000	Insulin rescued serum-deprived immortalized brown adipocytes from apoptosis through phosphatidylinositol (PI) 3-kinase and Akt pathways, but independently of p70S6-kinase, as demonstrated by the use of inhibitors such as LY294002 or Rapamycin, and transfection experiments with dominant-negative constructs of Akt or p85 subunit of PI 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	221-229	insulin	Homo sapiens	0-7
11027273-4	2000	The p54 isoform of c-jun N-terminal kinase-stress-activated kinase (JNK- SAPK) coimmunoprecipitated with Akt from me-v macrophages, and treatment of me-v cells with the specific phosphatidylinositol 3-kinase inhibitor LY294002 decreased cell survival, Akt and JNK kinase activities, ets-2 phosphorylation, and Bcl-x mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	E26 avian leukemia oncogene 1, 5' domain	Mus musculus	4-7
11040049-5	2000	The rGSTA2 mRNA level was elevated by SAAD beginning at 24 h, whereas the rGSTA2 subunit was maximally induced at 48 h. Nuclear ARE activation and rGSTA2 mRNA increase were both completely inhibited by wortmannin or LY294002, the phosphatidylinositol 3-kinase (PI3-kinase) inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	216-224	glutathione S-transferase alpha 2	Rattus norvegicus	4-10
11040049-5	2000	The rGSTA2 mRNA level was elevated by SAAD beginning at 24 h, whereas the rGSTA2 subunit was maximally induced at 48 h. Nuclear ARE activation and rGSTA2 mRNA increase were both completely inhibited by wortmannin or LY294002, the phosphatidylinositol 3-kinase (PI3-kinase) inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	216-224	glutathione S-transferase alpha 2	Rattus norvegicus	74-80
11040049-5	2000	The rGSTA2 mRNA level was elevated by SAAD beginning at 24 h, whereas the rGSTA2 subunit was maximally induced at 48 h. Nuclear ARE activation and rGSTA2 mRNA increase were both completely inhibited by wortmannin or LY294002, the phosphatidylinositol 3-kinase (PI3-kinase) inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	216-224	glutathione S-transferase alpha 2	Rattus norvegicus	74-80
10908564-6	2000	PI3K inhibitors, wortmannin or LY294002, significantly blocked the Akt kinase activity induced by EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	67-70
10908564-6	2000	PI3K inhibitors, wortmannin or LY294002, significantly blocked the Akt kinase activity induced by EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	epidermal growth factor	Homo sapiens	98-101
11034077-4	2000	Inactivation of the PI3K/AKT signal transduction pathway either by its specific inhibitor LY294002 or by expression of dominant negative AKT inhibited p21 expression but had no inhibitory effect on the expression of the proapoptotic protein BAX by cisplatin and paclitaxel treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	AKT serine/threonine kinase 2	Homo sapiens	25-28
11034077-4	2000	Inactivation of the PI3K/AKT signal transduction pathway either by its specific inhibitor LY294002 or by expression of dominant negative AKT inhibited p21 expression but had no inhibitory effect on the expression of the proapoptotic protein BAX by cisplatin and paclitaxel treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	cyclin dependent kinase inhibitor 1A	Homo sapiens	151-154
11062502-4	2000	V12Rac1 restores the activity of downstream effectors and lytic function in LY294002- or wortmannin-treated, but not PD98059-treated, NK cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	Rac family small GTPase 1	Homo sapiens	3-7
11018756-11	2000	On the other hand, PRL (100 ng/ml) inhibited apoptosis induced by Dex or IR; this effect of PRL was reversed by the addition of LY294002 (10 microgram/ml).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	prolactin	Rattus norvegicus	19-22
11006227-8	2000	The PI-3 kinase 85-kDa subunit was decreased 25% in LY294002-treated tissue, and collagen binding also decreased significantly in tissues treated with MEK-1 and PI-3 kinase inhibitors compared with control tissues.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	dual specificity mitogen-activated protein kinase kinase 1	Oryctolagus cuniculus	151-156
11018756-11	2000	On the other hand, PRL (100 ng/ml) inhibited apoptosis induced by Dex or IR; this effect of PRL was reversed by the addition of LY294002 (10 microgram/ml).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	prolactin	Rattus norvegicus	92-95
10896935-6	2000	Treatment with LY294002, an inhibitor for phosphoinositide 3-OH kinase (PI3K), significantly inhibits Ha-Ras(Val-12)-induced CD44 cleavage, whereas that with PD98059, an inhibitor for MEK, does not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	CD44 antigen	Mus musculus	125-129
10987830-8	2000	In addition, LY294002, a specific inhibitor of phosphatidylinositol 3-kinase, blocked the enhancement of BDNF-promoted neuronal survival in both neurons expressing wild-type and 4F mutant BIT/SHPS-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	brain-derived neurotrophic factor	Rattus norvegicus	105-109
10987830-8	2000	In addition, LY294002, a specific inhibitor of phosphatidylinositol 3-kinase, blocked the enhancement of BDNF-promoted neuronal survival in both neurons expressing wild-type and 4F mutant BIT/SHPS-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	signal-regulatory protein alpha	Rattus norvegicus	188-191
10987830-8	2000	In addition, LY294002, a specific inhibitor of phosphatidylinositol 3-kinase, blocked the enhancement of BDNF-promoted neuronal survival in both neurons expressing wild-type and 4F mutant BIT/SHPS-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	signal-regulatory protein alpha	Rattus norvegicus	192-198
11090628-0	2000	Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	27-52
11090628-1	2000	The specific phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and LY294002 have been invaluable tools for elucidating the roles of these enzymes in signal transduction pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	13-38
10896935-6	2000	Treatment with LY294002, an inhibitor for phosphoinositide 3-OH kinase (PI3K), significantly inhibits Ha-Ras(Val-12)-induced CD44 cleavage, whereas that with PD98059, an inhibitor for MEK, does not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	42-70
10896935-6	2000	Treatment with LY294002, an inhibitor for phosphoinositide 3-OH kinase (PI3K), significantly inhibits Ha-Ras(Val-12)-induced CD44 cleavage, whereas that with PD98059, an inhibitor for MEK, does not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	midkine	Mus musculus	184-187
10896935-6	2000	Treatment with LY294002, an inhibitor for phosphoinositide 3-OH kinase (PI3K), significantly inhibits Ha-Ras(Val-12)-induced CD44 cleavage, whereas that with PD98059, an inhibitor for MEK, does not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	Harvey rat sarcoma virus oncogene	Mus musculus	102-108
11030146-5	2000	EGF stimulated FKHR phosphorylation was blocked by the PI3 kinase inhibitor LY294002, and the ErbB1 inhibitor AG1478.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	epidermal growth factor	Homo sapiens	0-3
11027504-6	2000	LY294002, a PI3-kinase inhibitor, suppressed in a dose-dependent manner not only muscle differentiation but also activation of p38 MAPK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen activated protein kinase 14	Rattus norvegicus	127-135
11027504-9	2000	Interestingly, LY294002 also suppressed differentiation of H9c2 cells expressing Ha-p38 or MKK6(glu).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mitogen activated protein kinase 14	Rattus norvegicus	84-87
11027504-9	2000	Interestingly, LY294002 also suppressed differentiation of H9c2 cells expressing Ha-p38 or MKK6(glu).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	mitogen-activated protein kinase kinase 6	Rattus norvegicus	91-95
11030146-5	2000	EGF stimulated FKHR phosphorylation was blocked by the PI3 kinase inhibitor LY294002, and the ErbB1 inhibitor AG1478.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	forkhead box O1	Homo sapiens	15-19
11002428-5	2000	The survival effect of high concentration Ang2 was blocked by pre-treatment with soluble Tie2 receptor and the PI 3"-kinase-specific inhibitors, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	angiopoietin 2	Homo sapiens	42-46
10996657-5	2000	Incubating cultured bovine aorta endothelial cells and 3T3-L1 adipocytes with either wortmannin or LY294002 caused a time- and concentration-dependent decrease in myo-inositol accumulation that was independent of changes in SMIT mRNA levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	sodium/myo-inositol cotransporter	Bos taurus	224-228
10996657-9	2000	Co-incubation of cultured bovine aorta endothelial cells and 3T3-L1 adipocytes with either wortmannin or LY294002 and hyperosmotic medium caused a significant decrease in the induction of myo-inositol accumulation by hyperosmolarity without significantly affecting the hyperosmotic-induced increase in SMIT mRNA levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	sodium/myo-inositol cotransporter	Bos taurus	302-306
10979966-7	2000	Inhibition of PI3 kinase by selective inhibitor (LY294002) abolished anti-IgE antibody- but not FMLP-induced phosphorylation of MEK1 (MAPK kinase/ERK kinase) and ERKs while inhibiting LTC4 generation as well as histamine release.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mitogen-activated protein kinase 3	Homo sapiens	162-166
10961875-6	2000	The importance of MAPK and Akt/PKB signaling pathways in regulating the expression of Mcl-1 and cell survival was further supported by the observation that inhibition of MEK by PD98059 or phosphatidylinositol-3 kinase (PI-3K) by LY294002 independently resulted in the reduction of Mcl-1 expression and loss of cell viability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	AKT serine/threonine kinase 1	Homo sapiens	31-34
10927021-0	2000	Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the phosphatidylinositol 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-225	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	112-118
10927021-0	2000	Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the phosphatidylinositol 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	227-235	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	112-118
10961875-6	2000	The importance of MAPK and Akt/PKB signaling pathways in regulating the expression of Mcl-1 and cell survival was further supported by the observation that inhibition of MEK by PD98059 or phosphatidylinositol-3 kinase (PI-3K) by LY294002 independently resulted in the reduction of Mcl-1 expression and loss of cell viability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	86-91
10961875-6	2000	The importance of MAPK and Akt/PKB signaling pathways in regulating the expression of Mcl-1 and cell survival was further supported by the observation that inhibition of MEK by PD98059 or phosphatidylinositol-3 kinase (PI-3K) by LY294002 independently resulted in the reduction of Mcl-1 expression and loss of cell viability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	mitogen-activated protein kinase kinase 7	Homo sapiens	170-173
10961875-6	2000	The importance of MAPK and Akt/PKB signaling pathways in regulating the expression of Mcl-1 and cell survival was further supported by the observation that inhibition of MEK by PD98059 or phosphatidylinositol-3 kinase (PI-3K) by LY294002 independently resulted in the reduction of Mcl-1 expression and loss of cell viability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	188-217
10965905-8	2000	A different PI3K inhibitor, LY294002 (50 microM), substantially inhibited (roughly 72%) GH-induced MAP kinase activation in 32D-rbGHR-IRS-1 cells, but only marginally (and statistically insignificantly) inhibited GH-induced MAP kinase activation in 32D-rbGHR cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	isoleucine-tRNA synthetase	Mus musculus	134-137
10965879-4	2000	IGFBP-3-induced potentiation was specifically prevented if an inhibitor of phosphatidylinositol 3 (PI3)-kinase activation (LY294002), but not an inhibitor of mitogen-activated protein kinase activation (PD98059), was present during the preincubation period.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	insulin like growth factor binding protein 3	Bos taurus	0-7
10965905-9	2000	Because GH-induced Akt activation was completely inhibited in both cells by the same concentration of LY294002, these findings indicate that the wortmannin sensitivity of both the IRS-1-independent and -dependent GH-induced MAP kinase activation may reflect the activity of another wortmannin-sensitive target(s) in addition to PI3K in mediation of GH-induced MAP kinase activation in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
10965905-9	2000	Because GH-induced Akt activation was completely inhibited in both cells by the same concentration of LY294002, these findings indicate that the wortmannin sensitivity of both the IRS-1-independent and -dependent GH-induced MAP kinase activation may reflect the activity of another wortmannin-sensitive target(s) in addition to PI3K in mediation of GH-induced MAP kinase activation in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	insulin receptor substrate 1	Rattus norvegicus	180-185
10829021-5	2000	LY294002, a PI-3 kinase inhibitor, blocks IGF-I-induced motility and FAK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 1	Homo sapiens	42-47
10927021-5	2000	Pretreatment of cultures with &gt;/= 10 microM LY294002 suppressed the TCDD activation of CYP1A1 (IC(50) approximately 10 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	47-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	90-96
10927021-7	2000	However, the addition of LY294002 to cytosol just prior to TCDD addition completely suppressed AHR transformation by TCDD (IC(50) approximately 35 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	aryl hydrocarbon receptor	Homo sapiens	95-98
10927021-10	2000	Analyses of the phosphorylation status of Akt-1, an in vivo substrate of PI 3-kinase, demonstrated that concentrations of LY294002 &gt;/= 50 microM and Wortmannin &gt;/= 10 nM completely suppressed PI 3-kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Homo sapiens	42-47
10927021-11	2000	Hence, the ability of LY294002 to suppress TCDD-dependent activation of CYP1A1 is unrelated to PI 3-kinase inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	72-78
10927021-12	2000	Instead, this activity reflects LY294002 functioning as an AHR antagonist.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	aryl hydrocarbon receptor	Homo sapiens	59-62
10829021-5	2000	LY294002, a PI-3 kinase inhibitor, blocks IGF-I-induced motility and FAK phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	protein tyrosine kinase 2	Homo sapiens	69-72
10958682-3	2000	Reexpression of PTEN or treatment with the PI3K inhibitor LY294002 abolished the levels of both PtdIns(3, 4)P2 and PtdIns(3,4,5)P3, reduced phosphorylation of PKB on Thr308 and Ser473, and inhibited PKB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	protein tyrosine kinase 2 beta	Homo sapiens	159-162
10869359-6	2000	Furthermore, expression of Akt inhibits epidermal growth factor-induced B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Homo sapiens	105-108
10869359-6	2000	Furthermore, expression of Akt inhibits epidermal growth factor-induced B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	136-141
10869359-6	2000	Furthermore, expression of Akt inhibits epidermal growth factor-induced B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Homo sapiens	105-108
10869359-6	2000	Furthermore, expression of Akt inhibits epidermal growth factor-induced B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	136-141
10958682-3	2000	Reexpression of PTEN or treatment with the PI3K inhibitor LY294002 abolished the levels of both PtdIns(3, 4)P2 and PtdIns(3,4,5)P3, reduced phosphorylation of PKB on Thr308 and Ser473, and inhibited PKB activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	protein tyrosine kinase 2 beta	Homo sapiens	199-202
10976992-7	2000	IGF-I was able to counteract the apoptotic stimulus of TNF-alpha and this was accompanied by the intranuclear translocation of PI 3-K. LY294002 inhibited both intranuclear translocation of PI 3-K and the rescuing effect of IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	insulin-like growth factor 1	Mus musculus	0-5
10835427-8	2000	In the presence of phosphatidylinositol (PI) 3-kinase inhibitors, wortmannin or LY294002, the HBx-mediated inhibitory effect on TGF-beta-induced apoptosis was alleviated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	X protein	Hepatitis B virus	94-97
10976992-7	2000	IGF-I was able to counteract the apoptotic stimulus of TNF-alpha and this was accompanied by the intranuclear translocation of PI 3-K. LY294002 inhibited both intranuclear translocation of PI 3-K and the rescuing effect of IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	tumor necrosis factor	Mus musculus	55-64
10976992-7	2000	IGF-I was able to counteract the apoptotic stimulus of TNF-alpha and this was accompanied by the intranuclear translocation of PI 3-K. LY294002 inhibited both intranuclear translocation of PI 3-K and the rescuing effect of IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	insulin-like growth factor 1	Mus musculus	223-228
11028544-12	2000	To a lesser extent, incubation of TNFalpha with inhibitors to NF-kappaB (SN50) and PI3K (LY294002) also increased apoptosis and decreased IL-8 production (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	tumor necrosis factor	Homo sapiens	34-42
11028544-12	2000	To a lesser extent, incubation of TNFalpha with inhibitors to NF-kappaB (SN50) and PI3K (LY294002) also increased apoptosis and decreased IL-8 production (P &lt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
10963684-6	2000	Two phosphatidylinositol 3"-kinase inhibitors, wortmannin and LY294002, reversed the neuroprotective effect of VEGF, implicating the phosphatidylinositol 3"-kinase/Akt signal transduction system in VEGF-mediated neuroprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	vascular endothelial growth factor A	Rattus norvegicus	111-115
10963684-6	2000	Two phosphatidylinositol 3"-kinase inhibitors, wortmannin and LY294002, reversed the neuroprotective effect of VEGF, implicating the phosphatidylinositol 3"-kinase/Akt signal transduction system in VEGF-mediated neuroprotection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	vascular endothelial growth factor A	Rattus norvegicus	198-202
10851233-8	2000	Further characterization of the zinc-induced activation of p70S6k using specific inhibitors of the p70S6k signaling pathway, namely rapamycin, wortmannin, and LY294002, showed that zinc acted upstream of mTOR/FRAP/RAFT and phosphatidylinositol 3-kinase (PI3K), because these inhibitors caused the inhibition of zinc-induced p70S6k activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	59-65
10851233-8	2000	Further characterization of the zinc-induced activation of p70S6k using specific inhibitors of the p70S6k signaling pathway, namely rapamycin, wortmannin, and LY294002, showed that zinc acted upstream of mTOR/FRAP/RAFT and phosphatidylinositol 3-kinase (PI3K), because these inhibitors caused the inhibition of zinc-induced p70S6k activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	99-105
10851233-8	2000	Further characterization of the zinc-induced activation of p70S6k using specific inhibitors of the p70S6k signaling pathway, namely rapamycin, wortmannin, and LY294002, showed that zinc acted upstream of mTOR/FRAP/RAFT and phosphatidylinositol 3-kinase (PI3K), because these inhibitors caused the inhibition of zinc-induced p70S6k activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	mechanistic target of rapamycin kinase	Mus musculus	204-208
10851233-8	2000	Further characterization of the zinc-induced activation of p70S6k using specific inhibitors of the p70S6k signaling pathway, namely rapamycin, wortmannin, and LY294002, showed that zinc acted upstream of mTOR/FRAP/RAFT and phosphatidylinositol 3-kinase (PI3K), because these inhibitors caused the inhibition of zinc-induced p70S6k activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	mechanistic target of rapamycin kinase	Mus musculus	209-213
10851233-8	2000	Further characterization of the zinc-induced activation of p70S6k using specific inhibitors of the p70S6k signaling pathway, namely rapamycin, wortmannin, and LY294002, showed that zinc acted upstream of mTOR/FRAP/RAFT and phosphatidylinositol 3-kinase (PI3K), because these inhibitors caused the inhibition of zinc-induced p70S6k activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	223-252
10851233-8	2000	Further characterization of the zinc-induced activation of p70S6k using specific inhibitors of the p70S6k signaling pathway, namely rapamycin, wortmannin, and LY294002, showed that zinc acted upstream of mTOR/FRAP/RAFT and phosphatidylinositol 3-kinase (PI3K), because these inhibitors caused the inhibition of zinc-induced p70S6k activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	99-105
10944433-5	2000	Such Epo-dependent activation of FKHRL1 apparently regulates the generation of Epo-dependent antiapoptotic signals as evidenced by the induction of apoptosis of erythroid progenitors during treatment of cells with the PI3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-254	erythropoietin	Homo sapiens	5-8
10835427-8	2000	In the presence of phosphatidylinositol (PI) 3-kinase inhibitors, wortmannin or LY294002, the HBx-mediated inhibitory effect on TGF-beta-induced apoptosis was alleviated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	transforming growth factor beta 1	Homo sapiens	128-136
10918442-10	2000	We found that switching off v-Src led to a decrease in the activity of both PI3-K and ERK1/2, however, we found that adding a specific inhibitor of PI3-K (LY294002) to v-Src transformed Rat-1 cells grown in low serum induced apoptosis while a specific ERK kinase (MEK1) inhibitor (PD98059) had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	30-33
10944433-5	2000	Such Epo-dependent activation of FKHRL1 apparently regulates the generation of Epo-dependent antiapoptotic signals as evidenced by the induction of apoptosis of erythroid progenitors during treatment of cells with the PI3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-254	forkhead box O3	Homo sapiens	33-39
10944433-5	2000	Such Epo-dependent activation of FKHRL1 apparently regulates the generation of Epo-dependent antiapoptotic signals as evidenced by the induction of apoptosis of erythroid progenitors during treatment of cells with the PI3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-254	erythropoietin	Homo sapiens	79-82
10944433-5	2000	Such Epo-dependent activation of FKHRL1 apparently regulates the generation of Epo-dependent antiapoptotic signals as evidenced by the induction of apoptosis of erythroid progenitors during treatment of cells with the PI3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	246-254	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	218-228
10910908-5	2000	EPO-induced phosphorylation of Akt was completely blocked by a PI3K-specific inhibitor, LY294002, at 10 micromol/L, indicating that activation of Akt by EPO is dependent on PI3K activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	erythropoietin	Homo sapiens	0-3
10910908-5	2000	EPO-induced phosphorylation of Akt was completely blocked by a PI3K-specific inhibitor, LY294002, at 10 micromol/L, indicating that activation of Akt by EPO is dependent on PI3K activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Homo sapiens	31-34
10910908-5	2000	EPO-induced phosphorylation of Akt was completely blocked by a PI3K-specific inhibitor, LY294002, at 10 micromol/L, indicating that activation of Akt by EPO is dependent on PI3K activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	AKT serine/threonine kinase 1	Homo sapiens	146-149
10910908-5	2000	EPO-induced phosphorylation of Akt was completely blocked by a PI3K-specific inhibitor, LY294002, at 10 micromol/L, indicating that activation of Akt by EPO is dependent on PI3K activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	erythropoietin	Homo sapiens	153-156
10985305-10	2000	IL-2 production remained sensitive to inhibition with the PI3K competitive inhibitor Ly294002, and to the fungal macrolide, rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	interleukin 2	Homo sapiens	0-4
10918442-10	2000	We found that switching off v-Src led to a decrease in the activity of both PI3-K and ERK1/2, however, we found that adding a specific inhibitor of PI3-K (LY294002) to v-Src transformed Rat-1 cells grown in low serum induced apoptosis while a specific ERK kinase (MEK1) inhibitor (PD98059) had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	mitogen activated protein kinase 3	Rattus norvegicus	86-92
10918442-10	2000	We found that switching off v-Src led to a decrease in the activity of both PI3-K and ERK1/2, however, we found that adding a specific inhibitor of PI3-K (LY294002) to v-Src transformed Rat-1 cells grown in low serum induced apoptosis while a specific ERK kinase (MEK1) inhibitor (PD98059) had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	170-173
10918442-10	2000	We found that switching off v-Src led to a decrease in the activity of both PI3-K and ERK1/2, however, we found that adding a specific inhibitor of PI3-K (LY294002) to v-Src transformed Rat-1 cells grown in low serum induced apoptosis while a specific ERK kinase (MEK1) inhibitor (PD98059) had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	155-163	mitogen activated protein kinase kinase 1	Rattus norvegicus	264-268
10927622-2	2000	Unexpectedly, this elevation of cyclin D1 expression by all of these agents is inhibited by the specific phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	cyclin D1	Homo sapiens	32-41
10927622-2	2000	Unexpectedly, this elevation of cyclin D1 expression by all of these agents is inhibited by the specific phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	105-134
10927622-4	2000	Here we show that inhibition of PI3-K by LY294002 decreases the half-life of the 4.5 kb cyclin D1 mRNA species.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	cyclin D1	Homo sapiens	88-97
10891487-4	2000	TCR-induced Akt/PKB activation is inhibited either by PI 3-kinase inhibitors (LY294002 and wortmannin) or by overexpression of a dominant negative mutant of Rac1 but not Cdc42.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	0-3
10899932-5	2000	Both IL-10 and IL-13 caused rapid activation of phosphatidylinositol (PI) 3-kinase, and inhibition of that kinase activity by wortmannin and LY294002 potently blocked the inhibitory effect of IL-10 and IL-13 on proinflammatory cytokine-mediated induction of ceramide production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	interleukin 10	Rattus norvegicus	5-10
10899932-5	2000	Both IL-10 and IL-13 caused rapid activation of phosphatidylinositol (PI) 3-kinase, and inhibition of that kinase activity by wortmannin and LY294002 potently blocked the inhibitory effect of IL-10 and IL-13 on proinflammatory cytokine-mediated induction of ceramide production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	interleukin 13	Rattus norvegicus	15-20
10899932-5	2000	Both IL-10 and IL-13 caused rapid activation of phosphatidylinositol (PI) 3-kinase, and inhibition of that kinase activity by wortmannin and LY294002 potently blocked the inhibitory effect of IL-10 and IL-13 on proinflammatory cytokine-mediated induction of ceramide production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	interleukin 10	Rattus norvegicus	192-197
10899932-5	2000	Both IL-10 and IL-13 caused rapid activation of phosphatidylinositol (PI) 3-kinase, and inhibition of that kinase activity by wortmannin and LY294002 potently blocked the inhibitory effect of IL-10 and IL-13 on proinflammatory cytokine-mediated induction of ceramide production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	interleukin 13	Rattus norvegicus	202-207
10900165-6	2000	It was found that CT-1 phosphorylated and activated Akt, and the effect was blocked by the PI3K inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	AKT serine/threonine kinase 1	Homo sapiens	52-55
10900165-7	2000	CT-1 also phosphorylated the pro-apoptotic factor, BAD, and the BAD phosphorylation was inhibited by LY294002, suggesting that phosphorylation of BAD is one of the key events by which the PI3K/Akt pathway mediates CT-1-induced survival signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	AKT serine/threonine kinase 1	Homo sapiens	193-196
10891487-4	2000	TCR-induced Akt/PKB activation is inhibited either by PI 3-kinase inhibitors (LY294002 and wortmannin) or by overexpression of a dominant negative mutant of Rac1 but not Cdc42.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	AKT serine/threonine kinase 1	Homo sapiens	12-15
10891487-4	2000	TCR-induced Akt/PKB activation is inhibited either by PI 3-kinase inhibitors (LY294002 and wortmannin) or by overexpression of a dominant negative mutant of Rac1 but not Cdc42.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	AKT serine/threonine kinase 1	Homo sapiens	16-19
10891487-6	2000	Similar to TCR stimulation, L61Rac-induced Akt/PKB kinase activity is also LY294002 and wortmannin sensitive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	AKT serine/threonine kinase 1	Homo sapiens	43-46
10891487-6	2000	Similar to TCR stimulation, L61Rac-induced Akt/PKB kinase activity is also LY294002 and wortmannin sensitive.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	AKT serine/threonine kinase 1	Homo sapiens	47-50
10913180-4	2000	In contrast, cell proliferation and the associated transient phosphorylation of Akt and p70(rsk) induced by sst(2(b)) receptors were blocked by the PI 3-K inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-174	AKT serine/threonine kinase 1	Homo sapiens	80-83
10880347-7	2000	Low concentrations (1.5 microM) of LY294002, a highly specific inhibitor of phosphoinositide 3-kinase (PI-3K), abolished 12-HETE-induced PAK1 activation, suggesting that PI-3K activation is upstream of 12-HETE-induced PAK1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	76-101
10913180-4	2000	In contrast, cell proliferation and the associated transient phosphorylation of Akt and p70(rsk) induced by sst(2(b)) receptors were blocked by the PI 3-K inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-174	ubiquitin associated and SH3 domain containing B	Homo sapiens	88-91
10913180-4	2000	In contrast, cell proliferation and the associated transient phosphorylation of Akt and p70(rsk) induced by sst(2(b)) receptors were blocked by the PI 3-K inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	165-174	ribosomal protein S6 kinase A2	Homo sapiens	92-95
10791951-5	2000	We also obtained results suggesting that the kinase inhibitors LY294002 and Wortmannin arrest cell growth and induce a senescence-like phenotype, at least partially, through inhibition of PI3K and protein kinase B/Akt, activation of the forkhead protein AFX, and up-regulation of p27(Kip1)expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	thymoma viral proto-oncogene 1	Mus musculus	214-217
10791951-5	2000	We also obtained results suggesting that the kinase inhibitors LY294002 and Wortmannin arrest cell growth and induce a senescence-like phenotype, at least partially, through inhibition of PI3K and protein kinase B/Akt, activation of the forkhead protein AFX, and up-regulation of p27(Kip1)expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	cyclin-dependent kinase inhibitor 1B	Mus musculus	280-283
10791951-5	2000	We also obtained results suggesting that the kinase inhibitors LY294002 and Wortmannin arrest cell growth and induce a senescence-like phenotype, at least partially, through inhibition of PI3K and protein kinase B/Akt, activation of the forkhead protein AFX, and up-regulation of p27(Kip1)expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	cyclin-dependent kinase inhibitor 1B	Mus musculus	284-288
10791951-7	2000	Our data suggest that repression of CDK2 activity by p27(Kip1) is required for the PI3K-induced senescence, yet mouse embryo fibroblasts derived from p27(Kip1-/-) mice entered cell cycle arrest after treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	cyclin-dependent kinase 2	Mus musculus	36-40
10791951-7	2000	Our data suggest that repression of CDK2 activity by p27(Kip1) is required for the PI3K-induced senescence, yet mouse embryo fibroblasts derived from p27(Kip1-/-) mice entered cell cycle arrest after treatment with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	215-223	cyclin-dependent kinase inhibitor 1B	Mus musculus	57-61
10880347-7	2000	Low concentrations (1.5 microM) of LY294002, a highly specific inhibitor of phosphoinositide 3-kinase (PI-3K), abolished 12-HETE-induced PAK1 activation, suggesting that PI-3K activation is upstream of 12-HETE-induced PAK1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	p21 (RAC1) activated kinase 1	Rattus norvegicus	137-141
10880347-7	2000	Low concentrations (1.5 microM) of LY294002, a highly specific inhibitor of phosphoinositide 3-kinase (PI-3K), abolished 12-HETE-induced PAK1 activation, suggesting that PI-3K activation is upstream of 12-HETE-induced PAK1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	p21 (RAC1) activated kinase 1	Rattus norvegicus	218-222
10861205-3	2000	The inhibitors of phosphoinositide 3-kinase (PI 3-kinase), wortmannin and LY 294002, abolished the insulin-dependent increase in SREBP1 mRNA, whereas the inhibitor of the mitogen- activated protein kinase cascade, PD 98059, was without effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-83	insulin	Homo sapiens	99-106
10801833-6	2000	Wortmannin (50 micrometer) and LY294002 (20 nm), which are PI 3-kinase inhibitors that by themselves had no effect on PKCepsilon activity, significantly suppressed PKCepsilon translocation activated by EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	protein kinase C epsilon	Homo sapiens	164-174
10801833-6	2000	Wortmannin (50 micrometer) and LY294002 (20 nm), which are PI 3-kinase inhibitors that by themselves had no effect on PKCepsilon activity, significantly suppressed PKCepsilon translocation activated by EGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	epidermal growth factor	Homo sapiens	202-205
10801833-7	2000	LY294002 also reversed the inhibitory action of EGF on chloride secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	epidermal growth factor	Homo sapiens	48-51
10861205-3	2000	The inhibitors of phosphoinositide 3-kinase (PI 3-kinase), wortmannin and LY 294002, abolished the insulin-dependent increase in SREBP1 mRNA, whereas the inhibitor of the mitogen- activated protein kinase cascade, PD 98059, was without effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-83	sterol regulatory element binding transcription factor 1	Homo sapiens	129-135
10749883-4	2000	Pretreatment of IIC9 cells with the selective PI 3-kinase inhibitor, LY294002 blocks the alpha-thrombin-stimulated increase in cyclin D1 protein and CDK4 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	G1/S-specific cyclin-D1	Cricetulus griseus	127-136
10861044-2	2000	As was found previously with steel factor, thapsigargin stimulated far more degranulation in SHIP-/- than in SHIP+/+ BMMCs, and this was blocked with the phosphatidylinositol-3 (PI-3) kinase inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	203-211	inositol polyphosphate-5-phosphatase D	Mus musculus	93-97
10764740-4	2000	Wortmannin and LY294002 reversed both effects, indicating that phosphatidylinositol 3-kinase mediates IGF-1-induced protein synthesis and eIF-2B activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	insulin like growth factor 1	Homo sapiens	102-107
10764740-4	2000	Wortmannin and LY294002 reversed both effects, indicating that phosphatidylinositol 3-kinase mediates IGF-1-induced protein synthesis and eIF-2B activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	138-144
10764740-5	2000	IGF-1 induced glycogen synthase kinase-3 (GSK-3) inactivation in a phosphatidylinositol 3-kinase-dependent fashion because it is inhibited by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	157-165	insulin like growth factor 1	Homo sapiens	0-5
10871858-11	2000	However, the effects of roscovitine appear to be distinct from those of LY294002, since roscovitine did not affect Akt activity while LY294002 significantly decreased the activity of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	AKT serine/threonine kinase 1	Homo sapiens	183-186
10749883-4	2000	Pretreatment of IIC9 cells with the selective PI 3-kinase inhibitor, LY294002 blocks the alpha-thrombin-stimulated increase in cyclin D1 protein and CDK4 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	cyclin-dependent kinase 4	Cricetulus griseus	149-153
10828839-11	2000	LY294002, a specific inhibitor of the intracellular signaling molecule phosphatidylinositol 3-kinase, inhibited stimulation of IGFBP-5 by IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin-like growth factor-binding protein 5	Oryctolagus cuniculus	127-134
10816436-9	2000	LY294002, a PI 3-kinase inhibitor, strongly depressed IGF-I-dependent DNA synthesis after pretreatment with and without TSH or dibutyryl cAMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin-like growth factor 1	Rattus norvegicus	54-59
10828025-6	2000	Potentiation of the collagen response by TPO is prevented in the presence of wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	92-100	thrombopoietin	Homo sapiens	41-44
10830300-4	2000	Here we demonstrate, using the inhibitors wortmannin and LY294002, that activation of phosphatidylinositol 3-kinase (PI3-K) is required for CSF-1-induced spreading in osteoclasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	86-115
10830300-4	2000	Here we demonstrate, using the inhibitors wortmannin and LY294002, that activation of phosphatidylinositol 3-kinase (PI3-K) is required for CSF-1-induced spreading in osteoclasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	colony stimulating factor 1	Homo sapiens	140-145
10963053-5	2000	The PI 3-kinase inhibitors wortmannin and LY294002 blocked IGF-I induced increases in PI 3-kinase activity and phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	insulin like growth factor 1	Homo sapiens	59-64
10963053-5	2000	The PI 3-kinase inhibitors wortmannin and LY294002 blocked IGF-I induced increases in PI 3-kinase activity and phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	AKT serine/threonine kinase 1	Homo sapiens	130-133
10963053-7	2000	The survival response to IGF-I was blocked by treatment with either wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	insulin like growth factor 1	Homo sapiens	25-30
10828839-11	2000	LY294002, a specific inhibitor of the intracellular signaling molecule phosphatidylinositol 3-kinase, inhibited stimulation of IGFBP-5 by IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin-like growth factor I	Oryctolagus cuniculus	138-143
10821851-5	2000	Here, we show that in MIN6 beta-cells, over-expression of p110.CAAX, a constitutively active form of phosphatidylinositol 3-kinase (PI3K) mimicked the activatory effects of glucose on PPI promoter activity, whereas Deltap85, a dominant negative form of the p85 subunit lacking the p110-binding domain, and the PI3K inhibitor LY 294002, blocked these effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	325-334	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	58-62
10847585-6	2000	This translocation is blocked by the phosphatidylinositol 3-kinase (PI 3-K) inhibitors, wortmannin and LY294002, suggesting that this event is PI 3-K dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	37-66
10821851-6	2000	Similarly, glucose-stimulated nuclear trans-location of endogenous PDX-1 was blocked by Deltap85 expression, and wortmannin or LY 294002 blocked the trans-location from the nuclear membrane to the nucleoplasm of epitope-tagged PDX-1.c-myc.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-136	pancreatic and duodenal homeobox 1	Mus musculus	227-232
10809731-6	2000	The plasma membrane localization of PLCbeta(1)-PH induced by serum and LPA was blocked by wortmannin pretreatment and by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	phospholipase C beta 1	Homo sapiens	36-49
10748004-3	2000	Phosphorylation of Akt is blocked by LY294002 or wortmannin, inhibitors of phosphatidylinositol 3-kinase (PI 3-kinase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	AKT serine/threonine kinase 1	Homo sapiens	19-22
10748004-4	2000	Consistent with these biochemical observations, TNF and IL-1 reduce apoptosis caused by growth factor and serum deprivation, and this action is also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	tumor necrosis factor	Homo sapiens	48-51
10748004-4	2000	Consistent with these biochemical observations, TNF and IL-1 reduce apoptosis caused by growth factor and serum deprivation, and this action is also blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	160-168	interleukin 1 alpha	Homo sapiens	56-60
10748004-6	2000	LY294002 potentiates the activation of mitogen-activated protein kinases and stress-activated protein kinases by TNF and IL-1, suggesting Akt inhibits these responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Homo sapiens	113-116
10872812-5	2000	While the IGF-I-induced activation of PKB/Akt was inhibited by PI3-K inhibitor LY294002 but not by MEK inhibitor PD98059, the activation of both MEK and ERK by IGF-I was inhibited by both.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	insulin like growth factor 1	Homo sapiens	10-15
10872812-5	2000	While the IGF-I-induced activation of PKB/Akt was inhibited by PI3-K inhibitor LY294002 but not by MEK inhibitor PD98059, the activation of both MEK and ERK by IGF-I was inhibited by both.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	38-41
10872812-5	2000	While the IGF-I-induced activation of PKB/Akt was inhibited by PI3-K inhibitor LY294002 but not by MEK inhibitor PD98059, the activation of both MEK and ERK by IGF-I was inhibited by both.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	AKT serine/threonine kinase 1	Homo sapiens	42-45
10748004-6	2000	LY294002 potentiates the activation of mitogen-activated protein kinases and stress-activated protein kinases by TNF and IL-1, suggesting Akt inhibits these responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 alpha	Homo sapiens	121-125
10748004-6	2000	LY294002 potentiates the activation of mitogen-activated protein kinases and stress-activated protein kinases by TNF and IL-1, suggesting Akt inhibits these responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	138-141
10799549-5	2000	Expression of a dominant negative mutant of p85 (regulatory component of PI3-K) and treatment with inhibitors of PI3-K (wortmannin and LY294002) prevented H(2)O(2)-induced Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	44-47
10799549-5	2000	Expression of a dominant negative mutant of p85 (regulatory component of PI3-K) and treatment with inhibitors of PI3-K (wortmannin and LY294002) prevented H(2)O(2)-induced Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Homo sapiens	172-175
10822383-11	2000	Inhibition of PI 3-kinase/AKT2 by wortmannin or LY294002 induces apoptosis in ovarian cancer cells exhibiting activation of the PI 3-kinase/AKT2 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 2	Homo sapiens	26-30
10788447-4	2000	The effect of IGF-1 was blocked by the phosphatidylinositide 3-kinase (PI3K) inhibitors LY294002 (50 micrometer) and wortmannin (0.5 micrometer), but not by the MEK inhibitor PD98059 (50 micrometer) or the p70 S6 kinase pathway inhibitor rapamycin (50 nm), suggesting that the stimulation of Akt by IGF-1 is mediated by the PI3K pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	insulin-like growth factor 1	Rattus norvegicus	14-19
10757809-10	2000	Transient transfection of a constitutively active PI3-kinase or an inducible Akt promoted myoblast viability in the absence of growth factors, while inhibition of PI3-kinase activity by the drug LY294002 selectively blocked IGF- but not PDGF-mediated muscle cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	AKT serine/threonine kinase 1	Homo sapiens	77-80
10811601-6	2000	Two phosphatidylinositol 3"-kinase (PI3-kinase)-specific inhibitors, wortmannin and LY294002, blocked the Ang1-induced antiapoptotic effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	angiopoietin 1	Homo sapiens	106-110
10792610-11	2000	Using two structurally unrelated PI3K inhibitors, wortmanin and LY294002, both tyrosine phosphorylation of Cx43 and activation of ERK stimulated by PDGF were largely blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	gap junction protein alpha 1	Homo sapiens	107-111
10792610-11	2000	Using two structurally unrelated PI3K inhibitors, wortmanin and LY294002, both tyrosine phosphorylation of Cx43 and activation of ERK stimulated by PDGF were largely blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	mitogen-activated protein kinase 1	Homo sapiens	130-133
10777606-7	2000	Both cAMP- and cGMP-elevating agents led to marked increases in Akt activation that was inhibited by the phosphatidylinositol 3"-kinase inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	cathelicidin antimicrobial peptide	Homo sapiens	5-9
10779388-5	2000	The alpha(1b)-adrenoceptor phosphorylation induced by lysophosphatidic acid was not blocked by genistein, a tyrosine kinase inhibitor, but it was inhibited by inhibitors of protein kinase C (bisindolylmaleimide I, staurosporine, and Ro 31-8220) and phosphoinositide 3-kinase (wortmannin and LY 294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	291-300	adrenoceptor alpha 1B	Rattus norvegicus	4-26
10777606-7	2000	Both cAMP- and cGMP-elevating agents led to marked increases in Akt activation that was inhibited by the phosphatidylinositol 3"-kinase inhibitors, LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Homo sapiens	64-67
10771089-0	2000	Phosphatidylinositol 3-kinase inhibitors, Wortmannin or LY294002, inhibited accumulation of p21 protein after gamma-irradiation by stabilization of the protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	H3 histone pseudogene 16	Homo sapiens	92-95
10771089-9	2000	Accumulation of p21 protein by gamma-irradiation was similar to that of DNA-PK intact cells and was reduced by Wortmannin or LY294002 pretreatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	H3 histone pseudogene 16	Homo sapiens	16-19
10771089-5	2000	Enhanced p21 protein expression in ML-1 cells resulting from 15 Gy gamma-irradiation was diminished by Wortmannin or LY294002 pretreatment of cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	H3 histone pseudogene 16	Homo sapiens	9-12
10771089-9	2000	Accumulation of p21 protein by gamma-irradiation was similar to that of DNA-PK intact cells and was reduced by Wortmannin or LY294002 pretreatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-133	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	72-78
10771089-7	2000	Wortmannin or LY294002 pretreatment reduces p53 expression after gamma-irradiation to a lesser degree than that of p21.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	tumor protein p53	Homo sapiens	44-47
10771089-10	2000	Involvement of another DNA damage detecting enzyme, the ATM gene product, whose activity is also inhibited by Wortmannin or LY294002, was evaluated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	124-132	ATM serine/threonine kinase	Homo sapiens	56-59
10771089-11	2000	ATM deficient cells induced p21 after gamma-irradiation, gamma-irradiation-induced p21 protein was diminished by pretreatment of cells with Wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	ATM serine/threonine kinase	Homo sapiens	0-3
10771089-8	2000	In addition, we examined the involvement of DNA-PK, whose activity is inhibited by Wortmannin or LY294002, in p21 stabilization using the SCID fibroblast cell line and a DNA-PK targeting ML-1 cell line.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	44-50
10771089-11	2000	ATM deficient cells induced p21 after gamma-irradiation, gamma-irradiation-induced p21 protein was diminished by pretreatment of cells with Wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	H3 histone pseudogene 16	Homo sapiens	83-86
10704378-7	2000	The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibited basolateral to apical transport by FcRn more than apical to basolateral transport, suggesting that there are differences in the mechanisms of transport in the two directions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	Fc gamma receptor and transporter	Rattus norvegicus	114-118
10771089-12	2000	We conclude that the p21 stabilization mechanism functions after gamma-irradiation, was sensitive to Wortmannin or LY294002, and required neither DNA-PK nor ATM gene product for activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	H3 histone pseudogene 16	Homo sapiens	21-24
10754327-8	2000	GM-CSF-dependent Akt and BAD phosphorylation was blocked by the PI 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	colony stimulating factor 2	Homo sapiens	0-6
10754327-8	2000	GM-CSF-dependent Akt and BAD phosphorylation was blocked by the PI 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	AKT serine/threonine kinase 1	Homo sapiens	17-20
10754327-9	2000	A role for the PI 3-kinase/Akt pathway in GM-CSF-stimulated delay of apoptosis was indicated by the ability of LY294002 to attenuate apoptosis delay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Homo sapiens	27-30
10754327-9	2000	A role for the PI 3-kinase/Akt pathway in GM-CSF-stimulated delay of apoptosis was indicated by the ability of LY294002 to attenuate apoptosis delay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	colony stimulating factor 2	Homo sapiens	42-48
10754327-13	2000	LY294002 blocked IL-8-dependent Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
10754327-13	2000	LY294002 blocked IL-8-dependent Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	32-35
10754327-14	2000	PD98059 and LY294002 significantly attenuated IL-8 delay of apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
10762606-5	2000	The phosphatidylinositol-3-kinase (PI3K) inhibitors wortmannin and LY-294002 each significantly attenuated transporter stimulation by amino acids.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-76	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	4-33
10753867-7	2000	Pharmacological inhibition of phosphatidylinositol (PI) 3-kinase, the upstream kinase of Akt, with LY294002 led to a 45% decrease in Bcl-2 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	AKT serine/threonine kinase 1	Rattus norvegicus	89-92
10753867-7	2000	Pharmacological inhibition of phosphatidylinositol (PI) 3-kinase, the upstream kinase of Akt, with LY294002 led to a 45% decrease in Bcl-2 promoter activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	BCL2, apoptosis regulator	Rattus norvegicus	133-138
10803462-7	2000	The activation of Akt by R-Ras3 was most likely to be PI3-K-dependent since this biochemical event was blocked by the pharmacological inhibitors, Wortmannin and LY294002, as well as by a dominant negative mutant of PI3-K. More importantly, R-Ras3 affinity-precipitated PI3-K from cell extracts in a GTP-dependent manner, and associated lipid kinase activity was readily detectable in R-Ras3 immune complexes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
10803462-7	2000	The activation of Akt by R-Ras3 was most likely to be PI3-K-dependent since this biochemical event was blocked by the pharmacological inhibitors, Wortmannin and LY294002, as well as by a dominant negative mutant of PI3-K. More importantly, R-Ras3 affinity-precipitated PI3-K from cell extracts in a GTP-dependent manner, and associated lipid kinase activity was readily detectable in R-Ras3 immune complexes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	muscle RAS oncogene homolog	Homo sapiens	25-31
10803462-7	2000	The activation of Akt by R-Ras3 was most likely to be PI3-K-dependent since this biochemical event was blocked by the pharmacological inhibitors, Wortmannin and LY294002, as well as by a dominant negative mutant of PI3-K. More importantly, R-Ras3 affinity-precipitated PI3-K from cell extracts in a GTP-dependent manner, and associated lipid kinase activity was readily detectable in R-Ras3 immune complexes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	muscle RAS oncogene homolog	Homo sapiens	240-246
10803462-7	2000	The activation of Akt by R-Ras3 was most likely to be PI3-K-dependent since this biochemical event was blocked by the pharmacological inhibitors, Wortmannin and LY294002, as well as by a dominant negative mutant of PI3-K. More importantly, R-Ras3 affinity-precipitated PI3-K from cell extracts in a GTP-dependent manner, and associated lipid kinase activity was readily detectable in R-Ras3 immune complexes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	161-169	muscle RAS oncogene homolog	Homo sapiens	240-246
10803462-9	2000	As expected, this biological activity of R-Ras3 was also abrogated by the addition of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	muscle RAS oncogene homolog	Homo sapiens	41-47
10749120-2	2000	Here we demonstrate that in human prostate cancer cells, basal-, growth factor-, and mitogen-induced expression of hypoxia-inducible factor 1 (HIF-1) alpha, the regulated subunit of the transcription factor HIF-1, is blocked by LY294002 and rapamycin, inhibitors of PI3K and FRAP, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	228-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-141
10737604-7	2000	Overexpression of PPT1 inhibited this C2-ceramide- or LY294002-mediated activation of caspase-3 by 50%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	palmitoyl-protein thioesterase 1	Homo sapiens	18-22
10737604-7	2000	Overexpression of PPT1 inhibited this C2-ceramide- or LY294002-mediated activation of caspase-3 by 50%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	caspase 3	Homo sapiens	86-95
10764145-4	2000	In contrast, the PI3-kinase inhibitors, LY294002 and wortmannin, did induce a significant increase in apoptosis in combination with cytotoxic drugs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	peptidase inhibitor 3	Homo sapiens	17-20
10734043-3	2000	Treatment of platelets with LY294002, an inhibitor of phosphatidylinositol 3- and phosphatidylinositol 4-kinases, resulted in a concentration-dependent inhibition of Ca(2+) entry stimulated by thapsigargin or the physiological agonist, thrombin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	coagulation factor II, thrombin	Homo sapiens	236-244
10734043-6	2000	LY294002 inhibited actin polymerization stimulated by thrombin or thapsigargin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	coagulation factor II, thrombin	Homo sapiens	54-62
10698715-4	2000	The participation of phosphoinositide 3-kinase (PI-3K) in Ca(2+)- and contraction-stimulated 3-O-methylglucose transport was suggested by the great sensitivity of this process towards the PI-3K inhibitors wortmannin and LY294002 and by the presence of PI-3K activity in anti-phosphotyrosine immunoprecipitates from contracted cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	21-46
10713398-4	2000	Both effects of IGF-1 do not depend on protein synthesis but are nullified by the phosphatidylinositol-3 kinase inhibitors, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	insulin-like growth factor 1	Rattus norvegicus	16-21
10734171-3	2000	Both PD98059 and U0126, MAP kinase/extracellular signal-regulated kinase (ERK) kinase inhibitors, and LY294002, a PI 3-kinase inhibitor, inhibited staurosporine-induced phosphorylation of p44/42 MAP kinases and cPLA(2) and PGE(2) production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	mitogen activated protein kinase 3	Rattus norvegicus	188-191
10734171-3	2000	Both PD98059 and U0126, MAP kinase/extracellular signal-regulated kinase (ERK) kinase inhibitors, and LY294002, a PI 3-kinase inhibitor, inhibited staurosporine-induced phosphorylation of p44/42 MAP kinases and cPLA(2) and PGE(2) production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	phospholipase A2 group IVA	Rattus norvegicus	211-218
10847485-11	2000	The addition of LY 294002, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, dose-dependently inhibited the PCcM induced increase in DNA synthesis to about 9% of the control values.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-25	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	29-58
10749120-2	2000	Here we demonstrate that in human prostate cancer cells, basal-, growth factor-, and mitogen-induced expression of hypoxia-inducible factor 1 (HIF-1) alpha, the regulated subunit of the transcription factor HIF-1, is blocked by LY294002 and rapamycin, inhibitors of PI3K and FRAP, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	228-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-155
10749120-2	2000	Here we demonstrate that in human prostate cancer cells, basal-, growth factor-, and mitogen-induced expression of hypoxia-inducible factor 1 (HIF-1) alpha, the regulated subunit of the transcription factor HIF-1, is blocked by LY294002 and rapamycin, inhibitors of PI3K and FRAP, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	228-236	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-148
10749120-2	2000	Here we demonstrate that in human prostate cancer cells, basal-, growth factor-, and mitogen-induced expression of hypoxia-inducible factor 1 (HIF-1) alpha, the regulated subunit of the transcription factor HIF-1, is blocked by LY294002 and rapamycin, inhibitors of PI3K and FRAP, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	228-236	mechanistic target of rapamycin kinase	Homo sapiens	275-279
10749120-4	2000	LY294002 and rapamycin also inhibit growth factor- and mitogen-induced secretion of vascular endothelial growth factor, the product of a known HIF-1 target gene, thus linking the PI3K/PTEN/AKT/FRAP pathway, HIF-1, and tumor angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	vascular endothelial growth factor A	Homo sapiens	84-118
10749120-4	2000	LY294002 and rapamycin also inhibit growth factor- and mitogen-induced secretion of vascular endothelial growth factor, the product of a known HIF-1 target gene, thus linking the PI3K/PTEN/AKT/FRAP pathway, HIF-1, and tumor angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-148
10749120-4	2000	LY294002 and rapamycin also inhibit growth factor- and mitogen-induced secretion of vascular endothelial growth factor, the product of a known HIF-1 target gene, thus linking the PI3K/PTEN/AKT/FRAP pathway, HIF-1, and tumor angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatase and tensin homolog	Homo sapiens	184-188
10749120-4	2000	LY294002 and rapamycin also inhibit growth factor- and mitogen-induced secretion of vascular endothelial growth factor, the product of a known HIF-1 target gene, thus linking the PI3K/PTEN/AKT/FRAP pathway, HIF-1, and tumor angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	189-192
10749120-4	2000	LY294002 and rapamycin also inhibit growth factor- and mitogen-induced secretion of vascular endothelial growth factor, the product of a known HIF-1 target gene, thus linking the PI3K/PTEN/AKT/FRAP pathway, HIF-1, and tumor angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Homo sapiens	193-197
10749120-4	2000	LY294002 and rapamycin also inhibit growth factor- and mitogen-induced secretion of vascular endothelial growth factor, the product of a known HIF-1 target gene, thus linking the PI3K/PTEN/AKT/FRAP pathway, HIF-1, and tumor angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	207-212
10702262-11	2000	However, treatment with LY 294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), inhibited basal Akt activity, up-regulated p27, and recruited cells in G(1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-33	AKT serine/threonine kinase 1	Homo sapiens	105-108
10702262-11	2000	However, treatment with LY 294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), inhibited basal Akt activity, up-regulated p27, and recruited cells in G(1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-33	interferon alpha inducible protein 27	Homo sapiens	132-135
10741711-0	2000	In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	62-91
10704824-4	2000	Pretreatment of pancreatic acini with LY294002 or wortmannin resulted in a concentration-dependent inhibition of tyrosine phosphorylation of p125(FAK), p130(Cas), and paxillin stimulated by carbachol or CCK-8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	protein tyrosine kinase 2	Rattus norvegicus	146-149
10704824-4	2000	Pretreatment of pancreatic acini with LY294002 or wortmannin resulted in a concentration-dependent inhibition of tyrosine phosphorylation of p125(FAK), p130(Cas), and paxillin stimulated by carbachol or CCK-8.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	phospholipase C-like 1	Rattus norvegicus	152-156
10681597-5	2000	LY294002, which inhibits all classes of PI3Ks, strongly suppressed Kit- and FcepsilonRI-induced responses in p85alpha -/- mast cells, revealing the contribution of another PI3K family member(s).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Fc epsilon receptor Ia	Homo sapiens	76-87
10681523-4	2000	Although the PE-induced phosphorylation of 4E-BP1 was blocked by the phosphatidylinositol 3-kinase inhibitor LY294002, neither phosphatidylinositol 3-kinase nor Akt, its downstream effector, is activated in cells treated with PE (Ballou, L. M., Cross, M. E., Huang, S., McReynolds, E. M., Zhang, B. X., and Lin, R. Z., J. Biol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	43-49
10741406-6	2000	The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 block dephosphorylation of cofilin and its association with the actin cytoskeleton.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	cofilin 1	Homo sapiens	96-103
10666335-4	2000	The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 rescued surfactant secretion from inhibition by SP-A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	surfactant protein A1	Homo sapiens	108-112
10681597-5	2000	LY294002, which inhibits all classes of PI3Ks, strongly suppressed Kit- and FcepsilonRI-induced responses in p85alpha -/- mast cells, revealing the contribution of another PI3K family member(s).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	109-117
10679787-5	2000	Two specific inhibitors of PI3-kinase, wortmannin and LY294002, efficiently blocked this neuroprotective effect of HGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	hepatocyte growth factor	Rattus norvegicus	115-118
10671568-4	2000	A dominant negative mutant (RasN17) of Ha-Ras blocked insulin-induced JNK activation, whereas a dominant negative mutant (RacN17) of Rac1 or a specific inhibitor (LY294002) of phosphoinositide 3-kinase did not, indicating a role for Ras, but not for Rac or phosphoinositide 3-kinase, in this effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	insulin	Homo sapiens	54-61
10666407-5	2000	SDF-1-induced platelet aggregation was also inhibited by wortmannin, LY294002, and genistein, suggesting that phosphatidylinositol 3-kinase and tyrosine kinase are likely involved in SDF-1-induced platelet aggregation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	C-X-C motif chemokine ligand 12	Homo sapiens	0-5
10666407-5	2000	SDF-1-induced platelet aggregation was also inhibited by wortmannin, LY294002, and genistein, suggesting that phosphatidylinositol 3-kinase and tyrosine kinase are likely involved in SDF-1-induced platelet aggregation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	C-X-C motif chemokine ligand 12	Homo sapiens	183-188
10677529-11	2000	VEGF mRNA levels are decreased in cells treated with the PI 3-kinase inhibitor LY294002 and restored by overexpression of v-P3k or Myr-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	vascular endothelial growth factor A	Gallus gallus	0-4
10623881-2	2000	The PI3K inhibitor LY294002 completely blocks insulin-stimulated glycogen synthesis by inhibiting glycogen synthase, PKB (Akt-1), and FRAP (RAFT) autophosphorylation, as well as p70 S6 kinase activation, whereas insulin receptor substrates tyrosine phosphorylation and MEK activity were not affected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	insulin receptor	Rattus norvegicus	212-228
10682681-6	2000	We have also shown, by use of exogenously expressed PTEN and by treatment with the PI3"-kinase inhibitor LY294002, that ERBB-2-induced invasion is dependent on the PI3"-kinase pathway; however, PTEN does not dephosphorylate FAK in these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	erb-b2 receptor tyrosine kinase 2	Homo sapiens	120-126
10868937-3	2000	The inhibitory effect of IGF-I on NOS-2 expression was abrogated when cells were incubated with wortmannin or LY294002, two inhibitors of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	insulin-like growth factor 1	Rattus norvegicus	25-30
10868937-3	2000	The inhibitory effect of IGF-I on NOS-2 expression was abrogated when cells were incubated with wortmannin or LY294002, two inhibitors of phosphatidylinositol 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	nitric oxide synthase 2	Rattus norvegicus	34-39
10665929-6	2000	Pretreatment of OK cells with the nonreceptor tyrosine kinase inhibitors genistein and herbimycin A or with the phosphatidylinositol 3-kinase (PI-3K) inhibitors wortmannin and LY294002 blocked the early and late peaks of PTH-stimulated ERK activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-184	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	112-141
10686085-10	2000	Similarly, the specific PI3K inhibitors, LY294002 and wortmannin, were able to inhibit the promotion of motor axon outgrowth by GDNF, but did not affect neuroprotective activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	glial cell derived neurotrophic factor	Homo sapiens	128-132
10623881-2	2000	The PI3K inhibitor LY294002 completely blocks insulin-stimulated glycogen synthesis by inhibiting glycogen synthase, PKB (Akt-1), and FRAP (RAFT) autophosphorylation, as well as p70 S6 kinase activation, whereas insulin receptor substrates tyrosine phosphorylation and MEK activity were not affected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	ribosomal protein S6 kinase B1	Rattus norvegicus	182-191
10707862-4	2000	This effect was associated with a marked activation of phosphatidylinositol 3-kinase by insulin-like growth factor-I, as evaluated by measurement of phosphatidylinositol 3-kinase activity in phosphotyrosine immunoprecipitates In order to establish a functional link between these observations, we then performed experiments employing two selective phosphatidylinositol 3-kinase inhibitors, namely wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	412-420	insulin like growth factor 1	Homo sapiens	88-116
10707862-7	2000	Incubation with either wortmannin or LY294002, dose-dependently reduced the mitogenic potential of insulin-like growth factor-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	insulin like growth factor 1	Homo sapiens	99-127
10674396-9	2000	In this light, the inhibition of IL-4-induced 3beta-HSD expression by wortmannin and LY294002, two potent PI 3-kinase inhibitors, indicates the probable involvement of the PI 3-kinase signaling molecules in this response to IL-4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	interleukin 4	Homo sapiens	33-37
10646509-9	2000	Both wortmannin and LY294002, which specifically block the phosphatidylinositol 3-kinase (PI3K) intracellular signaling pathway in motor neurons, inhibit BDNF-induced ES.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	brain-derived neurotrophic factor	Rattus norvegicus	154-158
10640750-7	2000	Consistent with its role in NF-kappa B activation, inhibition of PI 3-kinase activity by wortmannin or LY294002 greatly potentiated TNF-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	tumor necrosis factor	Homo sapiens	132-135
10674396-9	2000	In this light, the inhibition of IL-4-induced 3beta-HSD expression by wortmannin and LY294002, two potent PI 3-kinase inhibitors, indicates the probable involvement of the PI 3-kinase signaling molecules in this response to IL-4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	46-55
10674396-9	2000	In this light, the inhibition of IL-4-induced 3beta-HSD expression by wortmannin and LY294002, two potent PI 3-kinase inhibitors, indicates the probable involvement of the PI 3-kinase signaling molecules in this response to IL-4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	interleukin 4	Homo sapiens	224-228
10617634-6	2000	Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	0-3
10667605-4	2000	The expression of VEGF mRNA and protein by RAS-3 cells was strongly suppressed in the presence of LY294002, an inhibitor of phosphatidylinositol 3"-kinase, but remained largely unaffected in the same cells treated with an inhibitor (PD98059) of mitogen-activated protein/extracellular signal-regulated kinase kinase 1 (MKK/MEK-1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	vascular endothelial growth factor A	Rattus norvegicus	18-22
10667605-4	2000	The expression of VEGF mRNA and protein by RAS-3 cells was strongly suppressed in the presence of LY294002, an inhibitor of phosphatidylinositol 3"-kinase, but remained largely unaffected in the same cells treated with an inhibitor (PD98059) of mitogen-activated protein/extracellular signal-regulated kinase kinase 1 (MKK/MEK-1).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	mitogen activated protein kinase kinase 1	Rattus norvegicus	323-328
10667605-6	2000	The impact of mutant ras on VEGF expression was also significantly amplified at high cell density, conditions under which RAS-3 cells became less sensitive to LY294002-induced VEGF down-regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	vascular endothelial growth factor A	Rattus norvegicus	28-32
10667605-6	2000	The impact of mutant ras on VEGF expression was also significantly amplified at high cell density, conditions under which RAS-3 cells became less sensitive to LY294002-induced VEGF down-regulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	159-167	vascular endothelial growth factor A	Rattus norvegicus	176-180
10617634-6	2000	Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	Rac family small GTPase 1	Homo sapiens	24-28
11467775-5	2000	Similarly, P1-3 kinase inhibitors, Wortmannin and LY294002, strongly suppressed the FN-dependent secretion of MMP-9 together with the inhibition of Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	fibronectin 1	Homo sapiens	84-86
10601705-10	2000	Moreover, the PI 3"-kinase inhibitor LY294002 also inhibited phosphorylation of syk in PA-stimulated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	spleen associated tyrosine kinase	Homo sapiens	80-83
10648867-8	2000	Further studies showed that the BDNF-dependent expression GABA(A)alpha6 could also be reduced by LY294002, an inhibitor of the phosphatidylinositol 3-kinase, or depolarizing concentrations of KCl.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	brain derived neurotrophic factor	Mus musculus	32-36
10648867-8	2000	Further studies showed that the BDNF-dependent expression GABA(A)alpha6 could also be reduced by LY294002, an inhibitor of the phosphatidylinositol 3-kinase, or depolarizing concentrations of KCl.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	58-71
11263245-7	2000	Phosphorylation of c-Jun was necessary for the induction of apoptosis induced by LY294002 in cerebellar granule neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	19-24
11263245-9	2000	CONCLUSION: Caffeine inhibited the activation of JNK and decreased the phosphorylation of c-Jun to protect granule neurons from LY294002-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	128-136	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-95
10625300-11	2000	Inhibition of PI3 kinase activation by LY294002 or wortmannin abolished IGF-I-stimulated VSMC proliferation and reduced IGF-I-directed VSMC migration by approximately 60%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	insulin like growth factor 1	Homo sapiens	72-77
10625300-11	2000	Inhibition of PI3 kinase activation by LY294002 or wortmannin abolished IGF-I-stimulated VSMC proliferation and reduced IGF-I-directed VSMC migration by approximately 60%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	insulin like growth factor 1	Homo sapiens	120-125
10625301-5	2000	The PI 3"-kinase-specific inhibitors wortmannin and LY294002 blocked the Ang1-induced antiapoptotic effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	angiopoietin 1	Homo sapiens	73-77
10611455-3	2000	Wortmannin and LY294002, PI3-kinase inhibitors, partially reduced both the antigen-induced increases in the IL-4 mRNA levels and IL-4 production in a concentration-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 4	Rattus norvegicus	108-112
10611455-3	2000	Wortmannin and LY294002, PI3-kinase inhibitors, partially reduced both the antigen-induced increases in the IL-4 mRNA levels and IL-4 production in a concentration-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 4	Rattus norvegicus	129-133
10713726-6	2000	However, once cells are committed to differentiate, PI 3-kinase activity and expression dramatically decreases along with the differentiation programme, to become barely detectable after 96 h. Remarkably, LY294002 treatment leads to accumulation of cell in G1 phase and prevents DMSO-dependent cyclin D3 induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	205-213	cyclin D3	Homo sapiens	294-303
11467775-5	2000	Similarly, P1-3 kinase inhibitors, Wortmannin and LY294002, strongly suppressed the FN-dependent secretion of MMP-9 together with the inhibition of Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	matrix metallopeptidase 9	Homo sapiens	110-115
11467775-5	2000	Similarly, P1-3 kinase inhibitors, Wortmannin and LY294002, strongly suppressed the FN-dependent secretion of MMP-9 together with the inhibition of Akt activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	AKT serine/threonine kinase 1	Homo sapiens	148-151
10605036-4	2000	Pretreatment with the PI 3-kinase inhibitors, wortmannin and LY294002, effectively blocked fMLP-induced IL-1beta gene expression as well as NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	formyl peptide receptor 1	Homo sapiens	91-95
10605036-4	2000	Pretreatment with the PI 3-kinase inhibitors, wortmannin and LY294002, effectively blocked fMLP-induced IL-1beta gene expression as well as NF-kappaB activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	interleukin 1 beta	Homo sapiens	104-112
10601276-8	1999	When LY294002 and wortmannin, two specific inhibitors of PI 3-kinase, were added with Des(1-3)IGF-I, the IGF-I-regulated IGFBP-5 expression was negated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	insulin like growth factor 1	Homo sapiens	94-99
10658194-3	2000	Inhibitors of PI3K, wortmannin, and LY294002, induced a time-dependent activation of caspase-3 (CPP32), with a peak at 6 hr, leading to subsequent cell death by apoptosis in a dorsal root ganglion cell line (F-11).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	caspase 3	Homo sapiens	85-94
10658194-3	2000	Inhibitors of PI3K, wortmannin, and LY294002, induced a time-dependent activation of caspase-3 (CPP32), with a peak at 6 hr, leading to subsequent cell death by apoptosis in a dorsal root ganglion cell line (F-11).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	caspase 3	Homo sapiens	96-101
10611223-4	2000	p21-activated kinase 1 (PAK1) is activated by IL-3 in FL5.12 cells, and this activation is reduced by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	p21 (RAC1) activated kinase 1	Mus musculus	0-22
10611223-4	2000	p21-activated kinase 1 (PAK1) is activated by IL-3 in FL5.12 cells, and this activation is reduced by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	p21 (RAC1) activated kinase 1	Mus musculus	24-28
10601276-8	1999	When LY294002 and wortmannin, two specific inhibitors of PI 3-kinase, were added with Des(1-3)IGF-I, the IGF-I-regulated IGFBP-5 expression was negated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	insulin like growth factor 1	Homo sapiens	105-110
10601276-8	1999	When LY294002 and wortmannin, two specific inhibitors of PI 3-kinase, were added with Des(1-3)IGF-I, the IGF-I-regulated IGFBP-5 expression was negated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	insulin like growth factor binding protein 5	Homo sapiens	121-128
10593877-10	1999	Maximal translocation of PKC-zeta from the cytoplasm to the nucleus (as evaluated by immunoblotting, enzyme activity, and confocal microscopy) occurred after 12 min of exposure to NGF and was completely abrogated by either wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	237-245	nerve growth factor	Rattus norvegicus	180-183
10659996-6	1999	Experiments performed with LY294002 indicated that phosphatidylinositol 3-kinase contributed to the HGF-stimulated phosphorylation of Erk1/Erk2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	hepatocyte growth factor	Homo sapiens	100-103
10659996-6	1999	Experiments performed with LY294002 indicated that phosphatidylinositol 3-kinase contributed to the HGF-stimulated phosphorylation of Erk1/Erk2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	mitogen-activated protein kinase 3	Homo sapiens	134-138
10659996-6	1999	Experiments performed with LY294002 indicated that phosphatidylinositol 3-kinase contributed to the HGF-stimulated phosphorylation of Erk1/Erk2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	mitogen-activated protein kinase 1	Homo sapiens	139-143
10659996-7	1999	This finding was confirmed by the demonstration that the MAP kinase cascade-dependent expression of a high-Mr (&gt;300 kDa) protein pair appearing in the course of cell scattering was inhibited by LY294002 in HGF-induced cells but was not inhibited in phorbol ester-treated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	197-205	hepatocyte growth factor	Homo sapiens	209-212
10579338-5	1999	Both LY 294002 and PD 98059 lowered the IGF-1-induced increase of HGF in the medium by about 40%, but LY 294002 was 10 times more potent than PD 98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-14	insulin-like growth factor 1	Rattus norvegicus	40-45
10579338-5	1999	Both LY 294002 and PD 98059 lowered the IGF-1-induced increase of HGF in the medium by about 40%, but LY 294002 was 10 times more potent than PD 98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-14	hepatocyte growth factor	Rattus norvegicus	66-69
10579338-5	1999	Both LY 294002 and PD 98059 lowered the IGF-1-induced increase of HGF in the medium by about 40%, but LY 294002 was 10 times more potent than PD 98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-111	insulin-like growth factor 1	Rattus norvegicus	40-45
10585868-8	1999	The effects of insulin were inhibited by the PtdIns 3-kinase inhibitors wortmannin and LY294002 and by the SAPK2 inhibitor SB203580, suggesting that its effects were mediated via activation of PtdIns 3-kinase and SAPK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	insulin	Homo sapiens	15-22
10587349-4	1999	Furthermore, induction of CD14 expression in response to D(3) was abrogated by (a) the PI 3-kinase inhibitors LY294002 and wortmannin; (b) antisense oligonucleotides to mRNA for the p110 catalytic subunit of PI 3-kinase; and (c) a dominant negative mutant of PI 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	CD14 molecule	Homo sapiens	26-30
10587349-5	1999	In THP-1 cells, induction of CD11b expression by D(3) was also abrogated by LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	integrin subunit alpha M	Homo sapiens	29-34
10587349-6	1999	Similarly, LY294002 and wortmannin inhibited D(3)-induced expression of both CD14 and CD11b in peripheral blood monocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	CD14 molecule	Homo sapiens	77-81
10587349-6	1999	Similarly, LY294002 and wortmannin inhibited D(3)-induced expression of both CD14 and CD11b in peripheral blood monocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	integrin subunit alpha M	Homo sapiens	86-91
10567246-3	1999	Wortmannin and LY294002, specific inhibitors of phosphoinositide 3-kinases (PI 3-kinases), delay the disappearance of these structures and also correspondingly inhibit degradation of FcgammaRI-mediated immune complexes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	Fc gamma receptor Ia	Homo sapiens	183-192
10579326-2	1999	In subconfluent cultures, wortmannin, LY294002, and rapamycin reversed insulin- and EGF-induced [3H]thymidine incorporation into DNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	epidermal growth factor like 1	Rattus norvegicus	84-87
10559473-4	1999	Both wortmannin and LY-294002 inhibited PAF-induced aggregation that correlated with PI 3-kinase inhibition only when using lower concentrations of PAF giving reversible aggregation (primary phase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	PCNA clamp associated factor	Homo sapiens	40-43
10594764-4	1999	When blocking signalling pathways initiated by c-met, we found that the inhibition of the phosphatidylinositol-3-OH (PI-3) kinase by wortmannin or LY294002 led to a total inhibition of the anti-apoptotic effect of HGF/SF, whereas the blockade of the MAP-kinase pathway by PD90859 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	47-52
10594764-4	1999	When blocking signalling pathways initiated by c-met, we found that the inhibition of the phosphatidylinositol-3-OH (PI-3) kinase by wortmannin or LY294002 led to a total inhibition of the anti-apoptotic effect of HGF/SF, whereas the blockade of the MAP-kinase pathway by PD90859 had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	hepatocyte growth factor	Homo sapiens	214-220
10640438-10	1999	Inhibitors of protein kinase C (PKC) (Ro318220, GF109203X) and the ERK cascade (PD98059) attenuated the increase in c-Jun induced by IL-1 beta, but LY294002 (an inhibitor of phosphatidylinositol 3" kinase) and SB203580 (an inhibitor of p38-MAPK, which also inhibits certain JNK isoforms) had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	Eph receptor B1	Rattus norvegicus	67-70
10567366-8	1999	On the other hand, the insulin effect was totally abolished by LY294002 (10 microM) and rapamycin (50 nM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	insulin	Homo sapiens	23-30
10600478-3	1999	To delineate possible signaling pathways accounting for these gene expression, a subset of specific kinase inhibitors, SB203580, PD98059, rapamycin, LY294002, and Ro-32-0432, which inhibit p38 (HOG), MEK (MAPKK), S6 kinase, PI3 kinase, and protein kinase C (PKC), respectively, were employed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	mitogen-activated protein kinase 14	Mus musculus	189-192
10559259-8	1999	Next, we found that ET-1-induced GLUT4 translocation was inhibited by the phosphatidylinositol (PI) 3-kinase inhibitors wortmannin or LY294002, but not by the phospholipase C inhibitor U-73122.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	endothelin 1	Homo sapiens	20-24
10559259-8	1999	Next, we found that ET-1-induced GLUT4 translocation was inhibited by the phosphatidylinositol (PI) 3-kinase inhibitors wortmannin or LY294002, but not by the phospholipase C inhibitor U-73122.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	solute carrier family 2 member 4	Homo sapiens	33-38
10570282-4	1999	In addition, the phosphoinositide 3 (PI 3)-kinase inhibitors wortmannin and LY294002, as well as the Gi protein inhibitor pertussis toxin, also inhibited the SDF-1-stimulated accumulation of PtdIns(3,4,5)P3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	C-X-C motif chemokine ligand 12	Homo sapiens	158-163
10590177-7	1999	The phosphatidylinositol 3-kinase (PI 3-K) inhibitor LY294002 blocked IGF-I-mediated protection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	4-33
10590177-7	1999	The phosphatidylinositol 3-kinase (PI 3-K) inhibitor LY294002 blocked IGF-I-mediated protection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	insulin-like growth factor 1	Rattus norvegicus	70-75
10559473-4	1999	Both wortmannin and LY-294002 inhibited PAF-induced aggregation that correlated with PI 3-kinase inhibition only when using lower concentrations of PAF giving reversible aggregation (primary phase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	peptidase inhibitor 3	Homo sapiens	85-89
10559473-4	1999	Both wortmannin and LY-294002 inhibited PAF-induced aggregation that correlated with PI 3-kinase inhibition only when using lower concentrations of PAF giving reversible aggregation (primary phase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-29	PCNA clamp associated factor	Homo sapiens	148-151
10537179-8	1999	IF microscopy of filamentous actin using rhodamine-conjugated phalloidin revealed a significant and rapid generation of both membrane ruffling and stress fibers in response to PRL, an effect inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	255-263	prolactin	Homo sapiens	176-179
10545192-5	1999	Preincubation with wortmannin and LY294002, two structurally and mechanistically different inhibitors of PI3-K, blocked the VS-mediated increase in MAPK activity and phosphorylation of ERK-1 and ERK-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	mitogen-activated protein kinase 3	Homo sapiens	185-190
10545192-5	1999	Preincubation with wortmannin and LY294002, two structurally and mechanistically different inhibitors of PI3-K, blocked the VS-mediated increase in MAPK activity and phosphorylation of ERK-1 and ERK-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	mitogen-activated protein kinase 1	Homo sapiens	195-200
10545192-5	1999	Preincubation with wortmannin and LY294002, two structurally and mechanistically different inhibitors of PI3-K, blocked the VS-mediated increase in MAPK activity and phosphorylation of ERK-1 and ERK-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	mitogen-activated protein kinase 3	Homo sapiens	148-152
10537063-5	1999	Incubation of neurons with a P13-kinase inhibitor, wortmannin or LY294002, blocked the effects of IGF-1 on NO-induced neurotoxicity and caspase-3-like activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	insulin like growth factor 1	Homo sapiens	98-103
10537063-5	1999	Incubation of neurons with a P13-kinase inhibitor, wortmannin or LY294002, blocked the effects of IGF-1 on NO-induced neurotoxicity and caspase-3-like activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	caspase 3	Homo sapiens	136-145
10537068-8	1999	In addition, the trophic actions of MK of suppressing apoptosis and suppressing the activation of caspase-3 were abolished by concomitant treatment with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase, and with wort-mannin or LY294002, specific inhibitors of phosphatidyl-inositol 3-kinase (PI 3-kinase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	midkine	Mus musculus	36-38
10537068-8	1999	In addition, the trophic actions of MK of suppressing apoptosis and suppressing the activation of caspase-3 were abolished by concomitant treatment with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase, and with wort-mannin or LY294002, specific inhibitors of phosphatidyl-inositol 3-kinase (PI 3-kinase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	caspase 3	Mus musculus	98-107
10574325-3	1999	Insulin-stimulated triacylglycerol synthesis and insulin-stimulated protein kinase B/Akt activity were inhibited by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY 294002, and the mitogen-activated protein kinase kinase inhibitor PD 98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	176-185	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
10514497-6	1999	Because the sequence (RIR)TQpSFSLQER contains a consensus substrate site for protein kinase B (PKB or Akt), we demonstrated that LY294002, an inhibitor of the upstream activator of PKB, phosphatidylinositol 3-kinase, inhibited flow-induced eNOS phosphorylation by 97% and NO production by 68%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	AKT serine/threonine kinase 1	Bos taurus	95-98
10514497-6	1999	Because the sequence (RIR)TQpSFSLQER contains a consensus substrate site for protein kinase B (PKB or Akt), we demonstrated that LY294002, an inhibitor of the upstream activator of PKB, phosphatidylinositol 3-kinase, inhibited flow-induced eNOS phosphorylation by 97% and NO production by 68%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	AKT serine/threonine kinase 1	Bos taurus	102-105
10514497-6	1999	Because the sequence (RIR)TQpSFSLQER contains a consensus substrate site for protein kinase B (PKB or Akt), we demonstrated that LY294002, an inhibitor of the upstream activator of PKB, phosphatidylinositol 3-kinase, inhibited flow-induced eNOS phosphorylation by 97% and NO production by 68%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	AKT serine/threonine kinase 1	Bos taurus	181-184
10514497-6	1999	Because the sequence (RIR)TQpSFSLQER contains a consensus substrate site for protein kinase B (PKB or Akt), we demonstrated that LY294002, an inhibitor of the upstream activator of PKB, phosphatidylinositol 3-kinase, inhibited flow-induced eNOS phosphorylation by 97% and NO production by 68%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	nitric oxide synthase 3	Bos taurus	240-244
10516133-3	1999	The presence of the phosphatidylinositol (PI) 3-kinase inhibitors LY-294002 and wortmannin totally eradicated ERK1 and ERK2 phosphorylation in response to insulin but not contraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-75	mitogen activated protein kinase 3	Rattus norvegicus	110-114
10516133-3	1999	The presence of the phosphatidylinositol (PI) 3-kinase inhibitors LY-294002 and wortmannin totally eradicated ERK1 and ERK2 phosphorylation in response to insulin but not contraction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-75	mitogen activated protein kinase 1	Rattus norvegicus	119-123
10527657-1	1999	The level of nitrite accumulation in the culture media of astrocytes activated with lipopolysaccharide (LPS) and interferon-gamma (IFN) was decreased by pretreatment of cells with LY294002, a quercetin derivative developed for phosphatidylinositol-3-kinase (PI3K) inhibitor, in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	interferon gamma	Mus musculus	113-135
10527657-1	1999	The level of nitrite accumulation in the culture media of astrocytes activated with lipopolysaccharide (LPS) and interferon-gamma (IFN) was decreased by pretreatment of cells with LY294002, a quercetin derivative developed for phosphatidylinositol-3-kinase (PI3K) inhibitor, in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	227-256
10527657-2	1999	The expression of iNOS mRNA in the astrocytes was inhibited by LY294002, as revealed by reverse transcriptional polymerase chain reaction and agarose gel electrophoresis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	nitric oxide synthase 2, inducible	Mus musculus	18-22
10527657-3	1999	The catalytic activity of astrocytic iNOS was also inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	nitric oxide synthase 2, inducible	Mus musculus	37-41
10527657-5	1999	These results suggest that LY294002 suppresses NO production in the astrocytes through not only the inhibition of iNOS mRNA expression but also the inhibition of the iNOS activity and that PI3K is not involved in the inhibitory actions of LY294002.pc 1999 Academic Press@p$hr	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	nitric oxide synthase 2, inducible	Mus musculus	114-118
10527657-5	1999	These results suggest that LY294002 suppresses NO production in the astrocytes through not only the inhibition of iNOS mRNA expression but also the inhibition of the iNOS activity and that PI3K is not involved in the inhibitory actions of LY294002.pc 1999 Academic Press@p$hr	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	nitric oxide synthase 2, inducible	Mus musculus	166-170
10502402-7	1999	The PKC inhibitors staurosporine and calphostin C, and the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002, also prevented TRAIL mRNA transcription by activated T cells, indicating a role for PKC and PI3-K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	59-88
10502402-7	1999	The PKC inhibitors staurosporine and calphostin C, and the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002, also prevented TRAIL mRNA transcription by activated T cells, indicating a role for PKC and PI3-K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-131	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	148-153
10516282-8	1999	Vasopressin stimulation of transport is also blocked by 5 microM LY-294002, a second inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-74	arginine vasopressin	Homo sapiens	0-11
10477262-5	1999	The stress-induced changes in eIF4E phosphorylation were totally abrogated by the p38 mitogen-activated protein (MAP) kinase inhibitor SB203580, and were partly inhibited by the phosphoinositide 3-kinase inhibitor LY294002 and the mammalian target of rapamycin (mTOR) inhibitor rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	214-222	eukaryotic translation initiation factor 4E	Homo sapiens	30-35
10499501-6	1999	The phosphatidylinositol-3 kinase inhibitor (LY294002), but not the mitogen-activated protein kinase kinase inhibitor (PD98059), blocks IGF-I enhancement of IGFBP-5 gene and protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	insulin like growth factor 1	Homo sapiens	136-141
10499501-6	1999	The phosphatidylinositol-3 kinase inhibitor (LY294002), but not the mitogen-activated protein kinase kinase inhibitor (PD98059), blocks IGF-I enhancement of IGFBP-5 gene and protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	insulin like growth factor binding protein 5	Homo sapiens	157-164
10491398-8	1999	A specific inhibitor of phosphoinositide 3-kinase (PI3K), LY294002, negated the effect of the monoclonal antibodies on the morphology of the Matrigel-embedded cells and on production of MMP-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	matrix metallopeptidase 2	Homo sapiens	186-191
10480882-2	1999	We found that inhibitors of the p42/p44 MAPK pathway (PD98059) and the PI3K-p70 S6K pathway (wortmannin, Ly294002, and rapamycin) all block thymidine incorporation stimulated by fetal calf serum in the resting mouse endothelial cell line 1G11.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	76-83
10491003-3	1999	Two unrelated chemical inhibitors of PI3-kinase, wortmannin and Ly294002, prevented ICAM-3 and ERM protein moesin polarization as well as the chemotaxis of PBL in response to SDF-1 alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	intercellular adhesion molecule 3	Homo sapiens	84-90
10491003-3	1999	Two unrelated chemical inhibitors of PI3-kinase, wortmannin and Ly294002, prevented ICAM-3 and ERM protein moesin polarization as well as the chemotaxis of PBL in response to SDF-1 alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	moesin	Homo sapiens	107-113
10493495-5	1999	Phosphorylation of AKT and GSK-3beta by CR-1 can be blocked by LY294002, a specific inhibitor of PI3K, thus leading to apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	AKT serine/threonine kinase 1	Homo sapiens	19-22
10493495-5	1999	Phosphorylation of AKT and GSK-3beta by CR-1 can be blocked by LY294002, a specific inhibitor of PI3K, thus leading to apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	glycogen synthase kinase 3 beta	Homo sapiens	27-36
10467260-6	1999	Both neo-transfected and the c-Akt dominant-negative transfected F-11 cells showed increased ceramide formation (twofold) in response to staurosporine, wortmannin, or LY294002; whereas cells with a constitutively active Akt (Myr-Akt) showed no increase in ceramide when treated with staurosporine, wortmannin, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	313-321	AKT serine/threonine kinase 1	Homo sapiens	31-34
10467260-6	1999	Both neo-transfected and the c-Akt dominant-negative transfected F-11 cells showed increased ceramide formation (twofold) in response to staurosporine, wortmannin, or LY294002; whereas cells with a constitutively active Akt (Myr-Akt) showed no increase in ceramide when treated with staurosporine, wortmannin, or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	AKT serine/threonine kinase 1	Homo sapiens	31-34
10464317-6	1999	Incubation of macrophages with wortmannin, LY294002, PD98059, SB203580, rapamycin, or antibodies against insulin receptors before insulin treatment and alpha(2)M* stimulation significantly reduced the insulin-augmented increase in IP(3) and [Ca(2+)](i) levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	alpha-2-macroglobulin	Homo sapiens	152-161
10473597-8	1999	The PI3K inhibitor LY294002 blocked M-CSF-mediated monocyte survival, an effect that was partially restored by caspase-9 inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	colony stimulating factor 1	Homo sapiens	36-41
10473597-8	1999	The PI3K inhibitor LY294002 blocked M-CSF-mediated monocyte survival, an effect that was partially restored by caspase-9 inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	caspase 9	Homo sapiens	111-120
10464317-4	1999	Insulin-augmented (125)I-alpha(2)M* binding to macrophages was severely reduced by wortmannin, LY294002, PD98059, SB203580, or rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	insulin	Homo sapiens	0-7
10464317-4	1999	Insulin-augmented (125)I-alpha(2)M* binding to macrophages was severely reduced by wortmannin, LY294002, PD98059, SB203580, or rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	alpha-2-macroglobulin	Homo sapiens	25-34
10477682-7	1999	LY294002 at similar concentrations also induces apoptosis of these cells, as evidenced by the appearance of annexin V-binding cells and DNA fragmentation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	annexin A5	Homo sapiens	108-117
10477682-9	1999	Interestingly, the acceleration of apoptosis by LY294002 was observed in the presence or absence of EPO.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	erythropoietin	Homo sapiens	100-103
10638524-1	1999	The effects of 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), an inhibitor of mammalian phosphatidylinositol 3-OH kinase, was tested on an insulin signaling-like pathway in the nematode Caenorhabditis elegans.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-63	insulin	Homo sapiens	153-160
10464169-3	1999	The expression of TNF-alpha by CD4(+) T cells can be inhibited by either, wortmannin (WN) or LY 294002, two phosphatidylinositol 3-kinase (PI 3-K) inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-102	tumor necrosis factor	Homo sapiens	18-27
10464169-3	1999	The expression of TNF-alpha by CD4(+) T cells can be inhibited by either, wortmannin (WN) or LY 294002, two phosphatidylinositol 3-kinase (PI 3-K) inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-102	CD4 molecule	Homo sapiens	31-34
10464169-3	1999	The expression of TNF-alpha by CD4(+) T cells can be inhibited by either, wortmannin (WN) or LY 294002, two phosphatidylinositol 3-kinase (PI 3-K) inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-102	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	108-137
10495776-5	1999	Peroxisome proliferator-induced ERK phosphorylation was blocked when cells were pretreated with the MEK (ERK kinase) inhibitor, PD098059, or the phosphatidyl-inositol 3-kinase (PI3K) inhibitors, LY294002 and apigenin, suggesting that both MEK and PI3K are involved in the initial response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	mitogen-activated protein kinase 1	Mus musculus	32-35
10495776-5	1999	Peroxisome proliferator-induced ERK phosphorylation was blocked when cells were pretreated with the MEK (ERK kinase) inhibitor, PD098059, or the phosphatidyl-inositol 3-kinase (PI3K) inhibitors, LY294002 and apigenin, suggesting that both MEK and PI3K are involved in the initial response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	midkine	Mus musculus	100-103
10495776-5	1999	Peroxisome proliferator-induced ERK phosphorylation was blocked when cells were pretreated with the MEK (ERK kinase) inhibitor, PD098059, or the phosphatidyl-inositol 3-kinase (PI3K) inhibitors, LY294002 and apigenin, suggesting that both MEK and PI3K are involved in the initial response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	mitogen-activated protein kinase 1	Mus musculus	105-108
10438590-5	1999	Activation of phosphatidylinositol (PI)3-kinase downstream of the IGF-IR was necessary for this process, as blocking PI 3-kinase activity with the specific inhibitor LY 294002 at 10 microM prevented disruption of the filamentous actin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-175	insulin like growth factor 1 receptor	Homo sapiens	66-72
10438590-5	1999	Activation of phosphatidylinositol (PI)3-kinase downstream of the IGF-IR was necessary for this process, as blocking PI 3-kinase activity with the specific inhibitor LY 294002 at 10 microM prevented disruption of the filamentous actin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-175	peptidase inhibitor 3	Homo sapiens	117-121
10432314-5	1999	The formation of inositol phosphates and phosphatidic acid (PA), two markers of phospholipase C (PLC) activation, by CRP are inhibited by between 50 and 85% in the presence of wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	191-199	C-reactive protein	Homo sapiens	117-120
10446216-2	1999	Inhibition of PI 3-kinase by LY294002 or wortmannin, two specific PI 3-kinase antagonists, or co-transfection with a dominant negative mutant of PI 3-kinase dose-dependently blocked stimulation of c-fos SRE by TNF-alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	197-202
10446216-3	1999	Similarly, LY294002 significantly diminished TNF-alpha-induced activation of JNK, suggesting that nuclear signaling triggered by TNF-alpha is dependent on PI 3-kinase-mediated activation of both c-fos SRE and JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	tumor necrosis factor	Rattus norvegicus	45-54
10446216-3	1999	Similarly, LY294002 significantly diminished TNF-alpha-induced activation of JNK, suggesting that nuclear signaling triggered by TNF-alpha is dependent on PI 3-kinase-mediated activation of both c-fos SRE and JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	mitogen-activated protein kinase 8	Rattus norvegicus	77-80
10446216-3	1999	Similarly, LY294002 significantly diminished TNF-alpha-induced activation of JNK, suggesting that nuclear signaling triggered by TNF-alpha is dependent on PI 3-kinase-mediated activation of both c-fos SRE and JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	tumor necrosis factor	Rattus norvegicus	129-138
10446216-3	1999	Similarly, LY294002 significantly diminished TNF-alpha-induced activation of JNK, suggesting that nuclear signaling triggered by TNF-alpha is dependent on PI 3-kinase-mediated activation of both c-fos SRE and JNK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	mitogen-activated protein kinase 8	Rattus norvegicus	195-212
10432314-7	1999	Wortmannin and LY294002 also partially inhibit elevation of Ca(2+) by CRP in murine megakaryocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	C-reactive protein, pentraxin-related	Mus musculus	70-73
10438468-6	1999	Inhibition of PI 3-kinase by wortmannin or LY294002 abolished the protection of IL-6 against TGF-beta-induced apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	interleukin 6	Homo sapiens	80-84
10438468-9	1999	Finally, inhibition of both STAT3 and PI 3-kinase by treating cells overexpressing the dominant-negative STAT3 with LY294002 completely blocked IL-6-induced survival signal.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	signal transducer and activator of transcription 3	Homo sapiens	28-33
10438468-9	1999	Finally, inhibition of both STAT3 and PI 3-kinase by treating cells overexpressing the dominant-negative STAT3 with LY294002 completely blocked IL-6-induced survival signal.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	signal transducer and activator of transcription 3	Homo sapiens	105-110
10438468-9	1999	Finally, inhibition of both STAT3 and PI 3-kinase by treating cells overexpressing the dominant-negative STAT3 with LY294002 completely blocked IL-6-induced survival signal.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	interleukin 6	Homo sapiens	144-148
10433995-3	1999	When we added LY294002 or wortmannin to sympathetic neurons, apoptosis in the presence of nerve growth factor (NGF) was very slow compared to that obtained by NGF deprivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	nerve growth factor	Homo sapiens	90-109
10428852-5	1999	Both angiotensin II and H(2)O(2) stimulation of Akt/PKB are abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002 (2(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), suggesting that PI3-K is an upstream mediator of Akt/PKB activation in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	angiotensinogen	Homo sapiens	5-19
10428852-5	1999	Both angiotensin II and H(2)O(2) stimulation of Akt/PKB are abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002 (2(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), suggesting that PI3-K is an upstream mediator of Akt/PKB activation in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Homo sapiens	48-51
10428852-5	1999	Both angiotensin II and H(2)O(2) stimulation of Akt/PKB are abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002 (2(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), suggesting that PI3-K is an upstream mediator of Akt/PKB activation in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Homo sapiens	52-55
10433995-3	1999	When we added LY294002 or wortmannin to sympathetic neurons, apoptosis in the presence of nerve growth factor (NGF) was very slow compared to that obtained by NGF deprivation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	nerve growth factor	Homo sapiens	111-114
10428852-5	1999	Both angiotensin II and H(2)O(2) stimulation of Akt/PKB are abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002 (2(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), suggesting that PI3-K is an upstream mediator of Akt/PKB activation in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	77-106
10428852-5	1999	Both angiotensin II and H(2)O(2) stimulation of Akt/PKB are abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002 (2(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), suggesting that PI3-K is an upstream mediator of Akt/PKB activation in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Homo sapiens	250-253
10433995-8	1999	Similarly, approximately 50% of maximal NGF-stimulated PKB/Akt activity remained elevated at concentrations of LY294002 which completely blocked neurite outgrowth, a process known to be phosphoinositide 3-kinase dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	nerve growth factor	Homo sapiens	40-43
10428852-5	1999	Both angiotensin II and H(2)O(2) stimulation of Akt/PKB are abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002 (2(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), suggesting that PI3-K is an upstream mediator of Akt/PKB activation in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	AKT serine/threonine kinase 1	Homo sapiens	254-257
10412024-8	1999	Phosphorylation of the PI3K signaling target, Akt, was measured; TX14(A) and IGF-I increased Akt activity by 12-fold and 22-fold, respectively, that was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	AKT serine/threonine kinase 1	Homo sapiens	46-49
10428852-5	1999	Both angiotensin II and H(2)O(2) stimulation of Akt/PKB are abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002 (2(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), suggesting that PI3-K is an upstream mediator of Akt/PKB activation in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-198	angiotensinogen	Homo sapiens	5-19
10428852-5	1999	Both angiotensin II and H(2)O(2) stimulation of Akt/PKB are abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002 (2(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), suggesting that PI3-K is an upstream mediator of Akt/PKB activation in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-198	AKT serine/threonine kinase 1	Homo sapiens	48-51
10428852-5	1999	Both angiotensin II and H(2)O(2) stimulation of Akt/PKB are abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002 (2(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), suggesting that PI3-K is an upstream mediator of Akt/PKB activation in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-198	AKT serine/threonine kinase 1	Homo sapiens	52-55
10428852-5	1999	Both angiotensin II and H(2)O(2) stimulation of Akt/PKB are abrogated by the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002 (2(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one), suggesting that PI3-K is an upstream mediator of Akt/PKB activation in VSMCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-198	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	77-106
10424759-11	1999	Stimulated internalization also was blocked by wortmannin and LY 294002, which are relatively specific inhibitors of phosphatidylinositol 3-kinase (PI 3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-71	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	117-146
10436165-6	1999	Moreover, blockade of PI 3-kinase with 2 structurally dissimilar inhibitors (wortmannin or LY294002) abolished the capacity of IGF-I to maintain VSMC viability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	insulin like growth factor 1	Homo sapiens	127-132
10794595-4	1999	A phosphatidylinositol (PI) 3"-kinase inhibitor, LY294002, strongly and selectively inhibited intracellular calcium mobilization induced by PLD-treated membranes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	140-143
10412024-8	1999	Phosphorylation of the PI3K signaling target, Akt, was measured; TX14(A) and IGF-I increased Akt activity by 12-fold and 22-fold, respectively, that was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	insulin like growth factor 1	Homo sapiens	77-82
10412024-8	1999	Phosphorylation of the PI3K signaling target, Akt, was measured; TX14(A) and IGF-I increased Akt activity by 12-fold and 22-fold, respectively, that was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	AKT serine/threonine kinase 1	Homo sapiens	93-96
10428047-7	1999	However, LY 294002 at doses that inhibited the phosphorylation of Akt, a down-stream element of the PI 3-kinase, completely abolished the motoneuron survival effects of BDNF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-18	brain derived neurotrophic factor	Gallus gallus	169-173
10411946-6	1999	Protracted treatment with selective PI 3-K inhibitors, wortmannin and LY294002, abolished Akt-1 activity and induced neuronal death that could be reduced by long-term lithium pretreatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	AKT serine/threonine kinase 1	Homo sapiens	90-95
10419537-8	1999	Furthermore, in cells expressing normal levels of PLC-gamma1, chemotaxis was inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	phospholipase C gamma 1	Homo sapiens	50-60
10419527-4	1999	In addition, both PI 3- and PI 4-kinase activities of p110alpha and p110beta immunoprecipitates were similarly inhibited by either wortmannin or LY294002, specific inhibitors of p110.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	54-63
10419527-4	1999	In addition, both PI 3- and PI 4-kinase activities of p110alpha and p110beta immunoprecipitates were similarly inhibited by either wortmannin or LY294002, specific inhibitors of p110.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Mus musculus	68-76
10419527-4	1999	In addition, both PI 3- and PI 4-kinase activities of p110alpha and p110beta immunoprecipitates were similarly inhibited by either wortmannin or LY294002, specific inhibitors of p110.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	54-58
10409232-6	1999	In separate experiments, wortmannin and LY-294002 markedly inhibited PtdIns 3-kinase and 70-kDa S6 protein kinase (pp70(S6k)) activation induced by stimulation of human ASM cells with EGF and thrombin but had no effect on EGF- and thrombin-induced p42/p44 mitogen-activated protein kinase (MAPK) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-49	coagulation factor II, thrombin	Homo sapiens	192-200
10393094-6	1999	Other effective inhibitors of ODC induction proved to be genistein, manumycin A, herbimycin A, LY294002, wortmannin and KT5823, suggesting the involvement of other key proteins of signal-transduction pathways, i.e. Ras, Src, phosphatidylinositol 3-kinase and cGMP-dependent protein kinase, which may have a positive impact on MAPK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	ornithine decarboxylase, structural 1	Mus musculus	30-33
10403829-9	1999	Phosphatidylinositol 3-kinase (PI 3-kinase) might be a crucial enzyme in the signaling pathway since the specific inhibitor, LY 294002, was shown to inhibit HMG-CoA reductase activity and to completely abolish the stimulation by EGF in SKBR-3 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	125-134	epidermal growth factor	Homo sapiens	229-232
10409232-5	1999	Pretreatment of human ASM with the PtdIns 3-kinase inhibitors wortmannin and LY-294002 significantly reduced thrombin- and epidermal growth factor (EGF)-induced DNA synthesis (IC(50) approximately 10 nM and approximately 3 microM, respectively).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-86	coagulation factor II, thrombin	Homo sapiens	109-117
10409232-6	1999	In separate experiments, wortmannin and LY-294002 markedly inhibited PtdIns 3-kinase and 70-kDa S6 protein kinase (pp70(S6k)) activation induced by stimulation of human ASM cells with EGF and thrombin but had no effect on EGF- and thrombin-induced p42/p44 mitogen-activated protein kinase (MAPK) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-49	coagulation factor II, thrombin	Homo sapiens	231-239
10409232-6	1999	In separate experiments, wortmannin and LY-294002 markedly inhibited PtdIns 3-kinase and 70-kDa S6 protein kinase (pp70(S6k)) activation induced by stimulation of human ASM cells with EGF and thrombin but had no effect on EGF- and thrombin-induced p42/p44 mitogen-activated protein kinase (MAPK) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-49	cyclin dependent kinase 20	Homo sapiens	248-251
10364257-6	1999	Furthermore, the phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and LY294002 block Rac2 activation elicited by the receptor agonists, but not that by PMA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	Rac family small GTPase 2	Homo sapiens	91-95
10440129-8	1999	The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 blocked the effects of glucagon-like peptide-1 on DNA synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	glucagon	Rattus norvegicus	92-115
10440129-9	1999	Transcription factor pancreatic and duodenal homebox gene 1 (PDX-1) DNA binding activity was increased by glucagon-like peptide-1 at 3 or 11 mmol/l glucose and the phosphatidylinositol 3-kinase inhibitor LY294002 suppressed the action of glucagon-like peptide-1 on PDX-1 DNA binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	204-212	pancreatic and duodenal homeobox 1	Rattus norvegicus	21-59
10440129-9	1999	Transcription factor pancreatic and duodenal homebox gene 1 (PDX-1) DNA binding activity was increased by glucagon-like peptide-1 at 3 or 11 mmol/l glucose and the phosphatidylinositol 3-kinase inhibitor LY294002 suppressed the action of glucagon-like peptide-1 on PDX-1 DNA binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	204-212	pancreatic and duodenal homeobox 1	Rattus norvegicus	61-66
10440129-9	1999	Transcription factor pancreatic and duodenal homebox gene 1 (PDX-1) DNA binding activity was increased by glucagon-like peptide-1 at 3 or 11 mmol/l glucose and the phosphatidylinositol 3-kinase inhibitor LY294002 suppressed the action of glucagon-like peptide-1 on PDX-1 DNA binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	204-212	glucagon	Rattus norvegicus	238-261
10440129-9	1999	Transcription factor pancreatic and duodenal homebox gene 1 (PDX-1) DNA binding activity was increased by glucagon-like peptide-1 at 3 or 11 mmol/l glucose and the phosphatidylinositol 3-kinase inhibitor LY294002 suppressed the action of glucagon-like peptide-1 on PDX-1 DNA binding activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	204-212	pancreatic and duodenal homeobox 1	Rattus norvegicus	265-270
10386996-4	1999	Expression of SM-20 also increases during neuronal death caused by cytosine arabinoside or the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	egl-9 family hypoxia inducible factor 1	Homo sapiens	14-19
10445851-7	1999	Interestingly, expression of T/P was shown to initiate an apoptotic response that was enhanced by treatment of cells with the PI-3 kinase inhibitor LY294002, suggesting that T/P mediated cell death through activation of JNK/SAPK signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	mitogen-activated protein kinase 8	Mus musculus	220-223
10358141-5	1999	In all cases, cytokine-induced PKB activation was sensitive to inhibition by the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	protein tyrosine kinase 2 beta	Homo sapiens	31-34
10733346-3	1999	Attachment of U-251 MG cells to vitronectin, fibronectin, laminin, and collagen was inhibited in a concentration-dependent manner by two specific inhibitors of PI3-K (Wortmannin and LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	vitronectin	Homo sapiens	32-43
10733346-3	1999	Attachment of U-251 MG cells to vitronectin, fibronectin, laminin, and collagen was inhibited in a concentration-dependent manner by two specific inhibitors of PI3-K (Wortmannin and LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	fibronectin 1	Homo sapiens	45-56
10358077-13	1999	The PI 3-kinase inhibitors wortmannin and LY294002 inhibit IL-13 stimulation of protein kinase B as well as the cell survival effects of IL-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	interleukin 13	Homo sapiens	59-64
10380075-6	1999	Inclusion of wortmannin or LY294002, selective inhibitors of PI 3-K, reversed the insulin effect against apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	insulin	Homo sapiens	82-89
10380075-8	1999	Wortmannin or LY294002 also reversed this potentiation effect of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	insulin	Homo sapiens	65-72
10358077-13	1999	The PI 3-kinase inhibitors wortmannin and LY294002 inhibit IL-13 stimulation of protein kinase B as well as the cell survival effects of IL-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	interleukin 13	Homo sapiens	137-142
10362360-10	1999	A specific inhibitor of PI3-kinase, LY294002, abolished Etk activity and markedly increased TG-induced PARP cleavage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	poly(ADP-ribose) polymerase 1	Homo sapiens	103-107
10362694-3	1999	This stimulatory effect of IGF-I was prevented by the tyrosine kinase inhibitor genistein (5 microM) and by the specific phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin (100 nM) and LY-294002 (25 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	193-202	insulin like growth factor 1	Homo sapiens	27-32
10362672-6	1999	ANG II-stimulated Akt/PKB activation was inhibited by the tyrosine kinase inhibitors genistein and herbimycin A and by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-195	angiotensinogen	Homo sapiens	0-6
10362672-6	1999	ANG II-stimulated Akt/PKB activation was inhibited by the tyrosine kinase inhibitors genistein and herbimycin A and by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-195	AKT serine/threonine kinase 1	Homo sapiens	18-21
10362672-6	1999	ANG II-stimulated Akt/PKB activation was inhibited by the tyrosine kinase inhibitors genistein and herbimycin A and by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	186-195	AKT serine/threonine kinase 1	Homo sapiens	22-25
10392906-7	1999	This effect was sensitive to the PI3K inhibitors wortmannin or LY294002 and, therefore, attributed to the upregulation of PI3Kgamma expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	122-131
10333475-4	1999	This recruitment was dependent on the centaurin-alpha1 pleckstrin homology domains and was blocked by the PtdIns(4,5)P2 3-kinase (PI 3-kinase) inhibitors wortmannin (100 nM) and LY294002 (50 microM), and also by co-expression with a dominant negative p85.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	ArfGAP with dual PH domains 1	Rattus norvegicus	38-54
10339482-4	1999	PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	thymoma viral proto-oncogene 1	Mus musculus	49-52
10339482-4	1999	PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	thymoma viral proto-oncogene 1	Mus musculus	53-56
10339482-4	1999	PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	thymoma viral proto-oncogene 1	Mus musculus	125-128
10339482-4	1999	PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	thymoma viral proto-oncogene 1	Mus musculus	129-132
10339482-4	1999	PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	thymoma viral proto-oncogene 1	Mus musculus	125-128
10339482-4	1999	PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	thymoma viral proto-oncogene 1	Mus musculus	129-132
10363977-6	1999	These chemicals are competitive inhibitors of DNA-PK, with LY294002 having a Ki of 6.0 microM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	46-52
10342860-9	1999	By comparison, the antiapoptotic effects of insulin-like growth factor I on germ cells in cultured fetal ovaries were significantly attenuated by cotreating ovaries with LY294002 (P &lt; 0.05) but not with alpha-amanitin or cycloheximide (P &gt; 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	insulin-like growth factor 1	Mus musculus	44-72
10318871-4	1999	Treatment of wild type PDGFR-beta cells with combinations of PAO or orthovanadate and phosphatidylinositol 3-kinase inhibitors wortmannin or LY294002 resulted in a synergistic inhibition of PDGFR-beta-mediated cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	platelet derived growth factor receptor beta	Homo sapiens	23-33
10406184-11	1999	Further analysis revealed that LY294002, a selective inhibitor of phosphatidylinositol 3-kinase, suppressed DNA synthesis and cyclin D1 expression in a dose-dependent manner without affecting platelet-derived growth factor receptor beta expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	cyclin D1	Rattus norvegicus	126-135
10359590-6	1999	Similarly, inhibition of the PI3K-mTOR pathway by addition of the PI3K inhibitor 2-[4-morpholinyl]-8-phenyl-4H-1-benzopyran-4-one (LY294002) or the mTOR inhibitor rapamycin, although reducing several parameters of transformation, also failed to block transformation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	mechanistic target of rapamycin kinase	Homo sapiens	34-38
10330169-6	1999	The activation of Ras by low, but mitogenic, concentrations of EGF is therefore dependent on basal, rather than stimulated, PI 3-kinase activity; the inhibitory effects of LY294002 and wortmannin are due to their ability to reduce the activity of PI 3-kinase to below the level in a quiescent cell and reflect a permissive rather than an upstream regulatory role for PI 3-kinase in Ras activation in this system.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	epidermal growth factor	Homo sapiens	63-66
10330169-6	1999	The activation of Ras by low, but mitogenic, concentrations of EGF is therefore dependent on basal, rather than stimulated, PI 3-kinase activity; the inhibitory effects of LY294002 and wortmannin are due to their ability to reduce the activity of PI 3-kinase to below the level in a quiescent cell and reflect a permissive rather than an upstream regulatory role for PI 3-kinase in Ras activation in this system.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	peptidase inhibitor 3	Homo sapiens	247-251
10330169-6	1999	The activation of Ras by low, but mitogenic, concentrations of EGF is therefore dependent on basal, rather than stimulated, PI 3-kinase activity; the inhibitory effects of LY294002 and wortmannin are due to their ability to reduce the activity of PI 3-kinase to below the level in a quiescent cell and reflect a permissive rather than an upstream regulatory role for PI 3-kinase in Ras activation in this system.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	peptidase inhibitor 3	Homo sapiens	247-251
10352024-3	1999	Treatment of hepatocytes or WIF-B cells with phosphoinositide 3-kinase inhibitors, wortmannin or LY294002, led to accumulation of the apical plasma membrane proteins, 5"-nucleotidase and aminopeptidase N in lysosomal vacuoles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	5'-nucleotidase ecto	Homo sapiens	167-182
10352024-3	1999	Treatment of hepatocytes or WIF-B cells with phosphoinositide 3-kinase inhibitors, wortmannin or LY294002, led to accumulation of the apical plasma membrane proteins, 5"-nucleotidase and aminopeptidase N in lysosomal vacuoles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	alanyl aminopeptidase, membrane	Homo sapiens	187-203
10339425-9	1999	Consistent with this, rapamycin and LY294002 reduced the recovery of PKCzeta from the membrane fraction of transfected cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	protein kinase C zeta	Homo sapiens	69-76
10229863-2	1999	Incubation of activated macrophages with wortmannin and LY294002, two inhibitors of PI3-kinase, increased the amount of inducible nitric oxide synthase (iNOS) and the synthesis of nitric oxide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	nitric oxide synthase 2	Homo sapiens	120-151
10229863-2	1999	Incubation of activated macrophages with wortmannin and LY294002, two inhibitors of PI3-kinase, increased the amount of inducible nitric oxide synthase (iNOS) and the synthesis of nitric oxide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	nitric oxide synthase 2	Homo sapiens	153-157
10318871-4	1999	Treatment of wild type PDGFR-beta cells with combinations of PAO or orthovanadate and phosphatidylinositol 3-kinase inhibitors wortmannin or LY294002 resulted in a synergistic inhibition of PDGFR-beta-mediated cell migration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	platelet derived growth factor receptor beta	Homo sapiens	190-200
10355596-6	1999	The Na+/H+ exchange activity induced by thrombin was inhibited by a specific inhibitor of MAPK kinase, 2"-amino-3"-methoxyflavone (PD98059), but was not affected by a specific phosphatidylinositol-3-kinase inhibitor, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	217-265	coagulation factor II	Rattus norvegicus	40-48
10208753-6	1999	The Gbetagamma-dependent phosphorylation of the 62-kDa protein was inhibited by wortmannin or LY294002, which are mechanistically different inhibitors of phosphatidylinositol 3-kinase (PI3K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	154-183
10318967-3	1999	ATP-dependent transport of taurocholate and dinitrophenyl-glutathione in isolated canalicular vesicles from rat liver was reduced 50-70% by PI 3-kinase inhibitors, wortmannin, and LY294002, at concentrations that are specific for Type I PI 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	WAP four-disulfide core domain 15B	Rattus norvegicus	140-144
10318967-3	1999	ATP-dependent transport of taurocholate and dinitrophenyl-glutathione in isolated canalicular vesicles from rat liver was reduced 50-70% by PI 3-kinase inhibitors, wortmannin, and LY294002, at concentrations that are specific for Type I PI 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	WAP four-disulfide core domain 15B	Rattus norvegicus	237-241
10454216-4	1999	The crucial role of lipid second messengers in PKB activation has been dissected through the use of the PI 3-kinase-specific inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	AKT serine/threonine kinase 1	Homo sapiens	47-50
10212207-5	1999	We have demonstrated that the PI3K inhibitors, wortmannin and LY294002, were able to inhibit FAK-promoted migration in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	protein tyrosine kinase 2	Homo sapiens	93-96
10355596-6	1999	The Na+/H+ exchange activity induced by thrombin was inhibited by a specific inhibitor of MAPK kinase, 2"-amino-3"-methoxyflavone (PD98059), but was not affected by a specific phosphatidylinositol-3-kinase inhibitor, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	267-275	coagulation factor II	Rattus norvegicus	40-48
10208841-6	1999	LY294002 inhibited ERK1 activation completely and ERK2 activation by 42.9%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mitogen-activated protein kinase 3	Homo sapiens	19-23
10355596-7	1999	Thrombin-induced DNA synthesis was inhibited by LY294002, but not by PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	coagulation factor II	Rattus norvegicus	0-8
10094829-3	1999	The present work shows that thrombin-induced p70(s6k) activation is inhibited by the PI 3-kinase inhibitors wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-132	coagulation factor II	Mus musculus	28-36
10201993-5	1999	However, wortmannin and LY294002, but not rapamycin, blocked the ability of IL-4 and IGF-I to promote cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	interleukin 4	Homo sapiens	76-80
10201993-5	1999	However, wortmannin and LY294002, but not rapamycin, blocked the ability of IL-4 and IGF-I to promote cell survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	insulin like growth factor 1	Homo sapiens	85-90
10094829-3	1999	The present work shows that thrombin-induced p70(s6k) activation is inhibited by the PI 3-kinase inhibitors wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-132	ubiquitin associated and SH3 domain containing, B	Mus musculus	45-48
10094829-3	1999	The present work shows that thrombin-induced p70(s6k) activation is inhibited by the PI 3-kinase inhibitors wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-132	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	49-52
10187765-4	1999	Pre-treatment with the PI 3-kinase-specific inhibitors, wortmannin, and LY294002 effectively blocked BK-induced PI 3-kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	kininogen 1	Homo sapiens	101-103
10092673-7	1999	The pathway by which IGF-1 promotes neuronal survival and activation of NF-kappaB involves the phosphoinositol (PI) 3-kinase, because both effects of IGF-1 are blocked by LY294002 and wortmannin, two specific PI 3-kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	insulin-like growth factor 1	Mus musculus	21-26
10092673-7	1999	The pathway by which IGF-1 promotes neuronal survival and activation of NF-kappaB involves the phosphoinositol (PI) 3-kinase, because both effects of IGF-1 are blocked by LY294002 and wortmannin, two specific PI 3-kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	72-81
10092673-7	1999	The pathway by which IGF-1 promotes neuronal survival and activation of NF-kappaB involves the phosphoinositol (PI) 3-kinase, because both effects of IGF-1 are blocked by LY294002 and wortmannin, two specific PI 3-kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	insulin-like growth factor 1	Mus musculus	150-155
10187765-5	1999	Wortmannin and LY294002 also abolished BK-induced NF-kappaB activation, as did transient transfection with a dominant negative mutant of the p85 subunit.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	kininogen 1	Homo sapiens	39-41
10187765-5	1999	Wortmannin and LY294002 also abolished BK-induced NF-kappaB activation, as did transient transfection with a dominant negative mutant of the p85 subunit.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	141-144
10102683-7	1999	Wortmannin and LY294002, inhibitors of PI 3-kinase, reduced insulin-dependent activation of PKB, whereas rapamycin, an inhibitor of p70 S6 kinase, had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	insulin	Homo sapiens	60-67
10195934-8	1999	Pharmacological inhibitors of phosphatidylinositol-3 kinase, Wortmannin and LY294002, inhibit PDGF-BB and NGF-induced migration, whereas an inhibitor of MAP kinase kinase, PD98059, has no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	nerve growth factor	Homo sapiens	106-109
10102683-7	1999	Wortmannin and LY294002, inhibitors of PI 3-kinase, reduced insulin-dependent activation of PKB, whereas rapamycin, an inhibitor of p70 S6 kinase, had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	protein tyrosine kinase 2 beta	Homo sapiens	92-95
10082513-8	1999	Furthermore, the specific phosphatidylinositol-3 (PI-3) kinase inhibitor LY294002 inhibited the induction of phosphorylation of Ser18 of p53 by adriamycin to a higher degree in PKR+/+ cells than in PKR-/- cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	transformation related protein 53, pseudogene	Mus musculus	137-140
10213474-1	1999	Phosphatidylinositol 3-kinase (PI3-kinase) enzymes are key signalling molecules in the PC12 and neuronal cell survival pathway and are also involved in the regulation of retrograde axonal transport of nerve growth factor (NGF), with sympathetic neurons more sensitive to the effects of wortmannin/LY294002 than sensory neurons (Bartlett et al.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	297-305	nerve growth factor	Rattus norvegicus	201-220
10213474-1	1999	Phosphatidylinositol 3-kinase (PI3-kinase) enzymes are key signalling molecules in the PC12 and neuronal cell survival pathway and are also involved in the regulation of retrograde axonal transport of nerve growth factor (NGF), with sympathetic neurons more sensitive to the effects of wortmannin/LY294002 than sensory neurons (Bartlett et al.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	297-305	nerve growth factor	Rattus norvegicus	222-225
10082513-8	1999	Furthermore, the specific phosphatidylinositol-3 (PI-3) kinase inhibitor LY294002 inhibited the induction of phosphorylation of Ser18 of p53 by adriamycin to a higher degree in PKR+/+ cells than in PKR-/- cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	177-180
10082513-8	1999	Furthermore, the specific phosphatidylinositol-3 (PI-3) kinase inhibitor LY294002 inhibited the induction of phosphorylation of Ser18 of p53 by adriamycin to a higher degree in PKR+/+ cells than in PKR-/- cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	198-201
10208419-6	1999	Tyrosine phosphorylation of FAK, paxillin and p130Cas was inhibited by cytochalasin D or two specific inhibitors of phosphatidylinositol-3" kinase (PI-3" kinase), wortmannin and LY294002, indicating that their tyrosine phosphorylation depends on the formation of actin stress fiber and activation of PI-3" kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	protein tyrosine kinase 2	Homo sapiens	28-31
10082482-5	1999	ET-1-induced increase in cyclin D1 protein, and cdk4 kinase activity was not significantly inhibited by an inhibitor of the mitogen-activated protein kinase kinase 1/2, PD98059, nor by the protein kinase C inhibitor calphostin C, whereas ET-1-induced upregulation of cyclin D1 protein and cdk4 kinase activity was significantly inhibited by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	385-393	endothelin 1	Mus musculus	0-4
10082482-6	1999	In contrast, ET-1-induced activation of cdk2 kinase was significantly inhibited by PD98059, calphostin C, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	endothelin 1	Mus musculus	13-17
10082482-6	1999	In contrast, ET-1-induced activation of cdk2 kinase was significantly inhibited by PD98059, calphostin C, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	cyclin-dependent kinase 2	Mus musculus	40-44
10082482-8	1999	ET-1-induced increase in 3H-thymidine uptake was significantly inhibited by PD98059, calphostin C, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	endothelin 1	Mus musculus	0-4
10328886-6	1999	Experiments with wortmannin, LY294002, and rapamycin suggest that the peptide survival response is dependent on PI 3-kinase activity, but not p70 S6 kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	peptidase inhibitor 3	Homo sapiens	112-116
10208419-6	1999	Tyrosine phosphorylation of FAK, paxillin and p130Cas was inhibited by cytochalasin D or two specific inhibitors of phosphatidylinositol-3" kinase (PI-3" kinase), wortmannin and LY294002, indicating that their tyrosine phosphorylation depends on the formation of actin stress fiber and activation of PI-3" kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	paxillin	Homo sapiens	33-41
10208419-6	1999	Tyrosine phosphorylation of FAK, paxillin and p130Cas was inhibited by cytochalasin D or two specific inhibitors of phosphatidylinositol-3" kinase (PI-3" kinase), wortmannin and LY294002, indicating that their tyrosine phosphorylation depends on the formation of actin stress fiber and activation of PI-3" kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	178-186	BCAR1 scaffold protein, Cas family member	Homo sapiens	46-53
10066822-6	1999	Treatment with the PI 3-kinase inhibitors wortmannin and LY294002 also blocked MP-induced p42/p44 MAPK, p38, and JNK1 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	cyclin dependent kinase 20	Homo sapiens	90-93
10051434-5	1999	We have also shown that phosphoinositide 3-kinase (PI-3K) inhibitors (wortmannin and LY294002) decreased p42/p44 MAPK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	cyclin dependent kinase 20	Homo sapiens	105-108
10051434-5	1999	We have also shown that phosphoinositide 3-kinase (PI-3K) inhibitors (wortmannin and LY294002) decreased p42/p44 MAPK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	interferon induced protein 44	Homo sapiens	109-112
10051434-5	1999	We have also shown that phosphoinositide 3-kinase (PI-3K) inhibitors (wortmannin and LY294002) decreased p42/p44 MAPK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	mitogen-activated protein kinase 3	Homo sapiens	113-117
10066822-6	1999	Treatment with the PI 3-kinase inhibitors wortmannin and LY294002 also blocked MP-induced p42/p44 MAPK, p38, and JNK1 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	mitogen-activated protein kinase 3	Homo sapiens	94-102
10066820-5	1999	However, a combination of wortmannin or LY294002 with LPS or IL-1beta induced the expression of iNOS and the production of NO in C6 glial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	interleukin 1 beta	Rattus norvegicus	61-69
10066822-6	1999	Treatment with the PI 3-kinase inhibitors wortmannin and LY294002 also blocked MP-induced p42/p44 MAPK, p38, and JNK1 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	mitogen-activated protein kinase 14	Homo sapiens	104-107
10066820-5	1999	However, a combination of wortmannin or LY294002 with LPS or IL-1beta induced the expression of iNOS and the production of NO in C6 glial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	nitric oxide synthase 2	Rattus norvegicus	96-100
10066822-6	1999	Treatment with the PI 3-kinase inhibitors wortmannin and LY294002 also blocked MP-induced p42/p44 MAPK, p38, and JNK1 phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	mitogen-activated protein kinase 8	Homo sapiens	113-117
10022866-9	1999	Localization of Gab1 to areas of cell-cell contact is inhibited by LY294002, demonstrating that phosphatidylinositol 3-kinase activity is required.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	GRB2 associated binding protein 1	Homo sapiens	16-20
10064595-9	1999	LY294002 and wortmannin blocked these in vivo increases in Ser1039 phosphorylation, consistent with the notion that PI3Ks, and possibly p110delta itself, are involved in the in vivo phosphorylation of p110delta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	136-145
10064595-9	1999	LY294002 and wortmannin blocked these in vivo increases in Ser1039 phosphorylation, consistent with the notion that PI3Ks, and possibly p110delta itself, are involved in the in vivo phosphorylation of p110delta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	201-210
10051597-2	1999	Inhibition of endogenous PI 3-kinase activity with the specific inhibitor LY294002, or with dominant-negative mutants of PI 3-kinase, interferes with myotube formation and with the expression of muscle-specific proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	eukaryotic translation initiation factor 3 subunit K	Homo sapiens	195-210
10051597-6	1999	The inhibition of myotube formation and the reduced expression of muscle-specific proteins caused by the PI 3-kinase inhibitor LY294002 are completely reversed by constitutively active forms of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	eukaryotic translation initiation factor 3 subunit K	Homo sapiens	66-81
10051597-6	1999	The inhibition of myotube formation and the reduced expression of muscle-specific proteins caused by the PI 3-kinase inhibitor LY294002 are completely reversed by constitutively active forms of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	194-197
10051597-7	1999	Wild-type cellular Akt effects a partial reversal of LY294002-induced inhibition of myogenic differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	AKT serine/threonine kinase 1	Homo sapiens	19-22
9878764-1	1999	Cerebellar granule neurons maintained in medium containing 26 mM potassium or in medium (5 mM potassium) with 50 ng/ml brain-derived neurotrophic factor (BDNF) undergo an apoptotic cell death when exposed to 10 microM LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	brain derived neurotrophic factor	Homo sapiens	119-152
10723061-5	1999	Inhibitors of phosphatidylinositol 3-kinase (wortmannin and LY294002) also induced caspase-3 (CPP32) activation, increased ceramide formation, induced DNA fragmentation, and reduced cell viability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	caspase 3	Homo sapiens	83-92
10723061-5	1999	Inhibitors of phosphatidylinositol 3-kinase (wortmannin and LY294002) also induced caspase-3 (CPP32) activation, increased ceramide formation, induced DNA fragmentation, and reduced cell viability.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	caspase 3	Homo sapiens	94-99
9878764-1	1999	Cerebellar granule neurons maintained in medium containing 26 mM potassium or in medium (5 mM potassium) with 50 ng/ml brain-derived neurotrophic factor (BDNF) undergo an apoptotic cell death when exposed to 10 microM LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3-K).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	brain derived neurotrophic factor	Homo sapiens	154-158
9878764-2	1999	To investigate the intracellular signaling mechanism of LY294002-induced apoptosis, the activities of Akt and c-Jun N-terminal kinase (JNK) were measured in cells in HK (26 mM potassium) medium or LK+ (5 mM potassium) medium containing BDNF, with or without 10 microM LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	mitogen-activated protein kinase 8	Homo sapiens	135-138
9878764-3	1999	Akt activity decreased following the addition of 10 microM LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	AKT serine/threonine kinase 1	Homo sapiens	0-3
9878764-4	1999	In addition, we found that LY294002 increased the JNK activity, which is known to mediate some types of cell death in PNS neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	mitogen-activated protein kinase 8	Homo sapiens	50-53
9878764-5	1999	We also observed elevated expression of c-Jun by LY294002 in HK+ BDNF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-45
9878764-5	1999	We also observed elevated expression of c-Jun by LY294002 in HK+ BDNF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	brain derived neurotrophic factor	Homo sapiens	65-69
9895282-6	1999	Inhibition of phosphoinositide (PI) 3-kinase activity with chemical agents such as wortmannin or LY294002 partially blocked insulin-induced GLUT4 mRNA accumulation, insulin-induced GLUT4 protein content, GLUT4-CAT transactivation and glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	insulin	Homo sapiens	124-131
9895282-6	1999	Inhibition of phosphoinositide (PI) 3-kinase activity with chemical agents such as wortmannin or LY294002 partially blocked insulin-induced GLUT4 mRNA accumulation, insulin-induced GLUT4 protein content, GLUT4-CAT transactivation and glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	solute carrier family 2 member 4	Homo sapiens	140-145
9895282-6	1999	Inhibition of phosphoinositide (PI) 3-kinase activity with chemical agents such as wortmannin or LY294002 partially blocked insulin-induced GLUT4 mRNA accumulation, insulin-induced GLUT4 protein content, GLUT4-CAT transactivation and glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	insulin	Homo sapiens	165-172
9895282-6	1999	Inhibition of phosphoinositide (PI) 3-kinase activity with chemical agents such as wortmannin or LY294002 partially blocked insulin-induced GLUT4 mRNA accumulation, insulin-induced GLUT4 protein content, GLUT4-CAT transactivation and glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	solute carrier family 2 member 4	Homo sapiens	181-186
9895282-6	1999	Inhibition of phosphoinositide (PI) 3-kinase activity with chemical agents such as wortmannin or LY294002 partially blocked insulin-induced GLUT4 mRNA accumulation, insulin-induced GLUT4 protein content, GLUT4-CAT transactivation and glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	solute carrier family 2 member 4	Homo sapiens	181-186
9895282-6	1999	Inhibition of phosphoinositide (PI) 3-kinase activity with chemical agents such as wortmannin or LY294002 partially blocked insulin-induced GLUT4 mRNA accumulation, insulin-induced GLUT4 protein content, GLUT4-CAT transactivation and glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	catalase	Homo sapiens	210-213
10048588-5	1999	Selective inhibition of ERK, PI 3-kinase, and p70 S6 kinase with the inhibitors PD098059, LY294002, and rapamycin, respectively, inhibited VEGF-stimulated HUVEC proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	mitogen-activated protein kinase 1	Homo sapiens	24-27
9927327-12	1999	Lastly, the antiapoptotic effects of SCF/LIF or IGF-I were almost entirely eliminated by cotreatment of fetal ovaries with either one of two inhibitors of phosphatidylinositol-3"-kinase (PI3K), LY294002 (5 microM) or wortmannin (50 nM), whereas cotreatment with an inhibitor of p70 S6 kinase (rapamycin, 25 ng/ml) was without effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	kit ligand	Mus musculus	37-40
9927327-12	1999	Lastly, the antiapoptotic effects of SCF/LIF or IGF-I were almost entirely eliminated by cotreatment of fetal ovaries with either one of two inhibitors of phosphatidylinositol-3"-kinase (PI3K), LY294002 (5 microM) or wortmannin (50 nM), whereas cotreatment with an inhibitor of p70 S6 kinase (rapamycin, 25 ng/ml) was without effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	leukemia inhibitory factor	Mus musculus	41-44
9927327-12	1999	Lastly, the antiapoptotic effects of SCF/LIF or IGF-I were almost entirely eliminated by cotreatment of fetal ovaries with either one of two inhibitors of phosphatidylinositol-3"-kinase (PI3K), LY294002 (5 microM) or wortmannin (50 nM), whereas cotreatment with an inhibitor of p70 S6 kinase (rapamycin, 25 ng/ml) was without effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	194-202	insulin-like growth factor 1	Mus musculus	48-53
10048588-5	1999	Selective inhibition of ERK, PI 3-kinase, and p70 S6 kinase with the inhibitors PD098059, LY294002, and rapamycin, respectively, inhibited VEGF-stimulated HUVEC proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	vascular endothelial growth factor A	Homo sapiens	139-143
9891068-4	1999	The PI 3-kinase inhibitors LY294002 and wortmannin completely abrogated increases in both mRNA and protein levels of cyclin D1 and phosphorylation of pRb, inducing G1 arrest in EGF-stimulated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	cyclin D1	Mus musculus	117-126
10376934-6	1999	Similarly, wortmannin and LY294002 inhibited IL2-induced proliferation and markedly decreased the amount of prolactin transported to the nucleus.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	interleukin 2	Mus musculus	45-48
9891068-4	1999	The PI 3-kinase inhibitors LY294002 and wortmannin completely abrogated increases in both mRNA and protein levels of cyclin D1 and phosphorylation of pRb, inducing G1 arrest in EGF-stimulated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	RB transcriptional corepressor 1	Mus musculus	150-153
9891068-8	1999	The p110 induction of cyclin D1 in quiescent cells was strongly inhibited by coexpression of either of the PI 3-kinase DN forms, and by LY294002, but was independent of the Ras-MEK-ERK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	4-8
9891068-8	1999	The p110 induction of cyclin D1 in quiescent cells was strongly inhibited by coexpression of either of the PI 3-kinase DN forms, and by LY294002, but was independent of the Ras-MEK-ERK pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	136-144	cyclin D1	Mus musculus	22-31
10207623-8	1999	We have also found that DNA-PK activity can be inhibited by the PI 3-kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	24-30
9914387-0	1999	Angiotensin II stimulation of Ca2+-channel current in vascular smooth muscle cells is inhibited by lavendustin-A and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-126	angiotensinogen	Rattus norvegicus	0-14
9882612-8	1999	This is confirmed here by experiments which showed that PI3K inhibitors (wortmannin and LY294002) reduced the activation of p42/p44 MAPK by PDGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	mitogen-activated protein kinase 3	Homo sapiens	132-136
9927197-5	1999	The involvement of phosphatidylinositol 3-kinase downstream of Rac was demonstrated by the inhibition of Rac-induced cell survival by wortmannin and LY294002 and the presence of phosphatidylinositol kinase activity in the Rac immunoprecipitate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	thymoma viral proto-oncogene 1	Mus musculus	63-66
9927197-5	1999	The involvement of phosphatidylinositol 3-kinase downstream of Rac was demonstrated by the inhibition of Rac-induced cell survival by wortmannin and LY294002 and the presence of phosphatidylinositol kinase activity in the Rac immunoprecipitate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	thymoma viral proto-oncogene 1	Mus musculus	105-108
9927197-5	1999	The involvement of phosphatidylinositol 3-kinase downstream of Rac was demonstrated by the inhibition of Rac-induced cell survival by wortmannin and LY294002 and the presence of phosphatidylinositol kinase activity in the Rac immunoprecipitate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	thymoma viral proto-oncogene 1	Mus musculus	105-108
9927616-8	1999	Furthermore, the activation of ERK by the beta-3 AR is sensitive to PD98059, wortmannin, and LY294002, indicating a crucial role for mitogen-activated protein kinase kinase and phosphatidylinositol-3 kinase (PI3K), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	mitogen-activated protein kinase 1	Homo sapiens	31-34
9927616-8	1999	Furthermore, the activation of ERK by the beta-3 AR is sensitive to PD98059, wortmannin, and LY294002, indicating a crucial role for mitogen-activated protein kinase kinase and phosphatidylinositol-3 kinase (PI3K), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	adrenoceptor beta 3	Homo sapiens	42-51
9914387-9	1999	AngII stimulation of IBa was also prevented by (5 microM) LY-294002, an inhibitor of PI-3-K (n=5).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-67	angiotensinogen	Rattus norvegicus	0-5
9882612-8	1999	This is confirmed here by experiments which showed that PI3K inhibitors (wortmannin and LY294002) reduced the activation of p42/p44 MAPK by PDGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	cyclin dependent kinase 20	Homo sapiens	124-127
9882612-8	1999	This is confirmed here by experiments which showed that PI3K inhibitors (wortmannin and LY294002) reduced the activation of p42/p44 MAPK by PDGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	interferon induced protein 44	Homo sapiens	128-131
9920763-8	1999	However, eNOS mRNA upregulation was potentiated by the PI 3-kinase inhibitors wortmannin and LY294002, suggesting that PI 3-kinase inhibits the shear response.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	nitric oxide synthase 3	Bos taurus	9-13
10206340-4	1999	Inhibition of PI3-kinase with wortmannin and LY294002 blocked insulin-dependent activation of JNK1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	insulin	Homo sapiens	62-69
10206340-4	1999	Inhibition of PI3-kinase with wortmannin and LY294002 blocked insulin-dependent activation of JNK1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	mitogen-activated protein kinase 8	Homo sapiens	94-98
10576564-13	1999	However, pretreatment with wortmannin or LY294002, the inhibitor of phosphatidylinositol 3 kinase (PI-3K), strongly inhibited peptide-stimulated ERK1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	68-97
10423274-9	1999	When cells were preincubated with the phosphatidylinositide 3-kinase (PI3K) inhibitors wortmannin or LY294002, the PMA-induced GC morphological changes were inhibited but not membrane ruffles.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	38-68
9886485-7	1999	LY294002 significantly inhibited the induction of PPARgamma mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	50-59
9886485-8	1999	During the initiation phase of adipogenesis (day 4 to day 6), the expression of PPARgamma was induced and LY294002 blocked the increase of expression of PPARgamma mRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	peroxisome proliferator activated receptor gamma	Homo sapiens	153-162
10576564-13	1999	However, pretreatment with wortmannin or LY294002, the inhibitor of phosphatidylinositol 3 kinase (PI-3K), strongly inhibited peptide-stimulated ERK1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	mitogen-activated protein kinase 3	Homo sapiens	145-149
9860981-8	1998	In addition, the effect of PTEN on p27(KIP1) and the cell cycle can be mimicked by treatment of U87MG cells with LY294002, a selective inhibitor of PI 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	phosphatase and tensin homolog	Homo sapiens	27-31
9916799-7	1999	We show here that PIK3CA is frequently increased in copy number in ovarian cancers, that the increased copy number is associated with increased PIK3CA transcription, p110alpha protein expression and PI3-kinase activity and that treatment with the PI3-kinase inhibitor LY294002 decreases proliferation and increases apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	268-276	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	18-24
9860981-8	1998	In addition, the effect of PTEN on p27(KIP1) and the cell cycle can be mimicked by treatment of U87MG cells with LY294002, a selective inhibitor of PI 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	interferon alpha inducible protein 27	Homo sapiens	35-38
9860981-8	1998	In addition, the effect of PTEN on p27(KIP1) and the cell cycle can be mimicked by treatment of U87MG cells with LY294002, a selective inhibitor of PI 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	cyclin dependent kinase inhibitor 1B	Homo sapiens	39-43
9849961-4	1998	Furthermore, inhibition of PI 3-kinase activity with LY294002 blocks differentiation, as demonstrated by inhibition of myogenin and myosin heavy chain expression and ERK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	myogenin	Homo sapiens	119-127
9832443-10	1998	Moreover, IGF-II-induced human myotube formation was totally blocked by LY294002, a specific PI 3-kinase inhibitor, but remained unaffected in the presence of rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	insulin like growth factor 2	Homo sapiens	10-16
9852124-8	1998	Treating cells with the phosphatidylinositol 3"-kinase inhibitors wortmannin and LY294002 blocks IGF-I-induced membrane ruffling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	insulin like growth factor 1	Homo sapiens	97-102
9829964-6	1998	Akt/PKB induced CREB activity only in response to serum stimulation, and this effect was suppressed by the phosphatidylinositol 3-kinase inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-156	AKT serine/threonine kinase 1	Homo sapiens	0-7
9829964-6	1998	Akt/PKB induced CREB activity only in response to serum stimulation, and this effect was suppressed by the phosphatidylinositol 3-kinase inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-156	cAMP responsive element binding protein 1	Homo sapiens	16-20
9832424-6	1998	Treatment of the cells with PI 3-K inhibitors (wortmannin and LY294002) increased IGF-I-induced tyrosine phosphorylation of IRS-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	insulin like growth factor 1	Homo sapiens	82-87
9832424-6	1998	Treatment of the cells with PI 3-K inhibitors (wortmannin and LY294002) increased IGF-I-induced tyrosine phosphorylation of IRS-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-70	insulin receptor substrate 2	Homo sapiens	124-129
9849961-4	1998	Furthermore, inhibition of PI 3-kinase activity with LY294002 blocks differentiation, as demonstrated by inhibition of myogenin and myosin heavy chain expression and ERK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	mitogen-activated protein kinase 1	Homo sapiens	166-169
9822674-3	1998	Both BK-induced stimulation of DNA synthesis and activation of MAPK in response to BK were abolished by two different inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY 294002, as well as by two different inhibitors of protein kinase C (PKC), bisindolylmaleimide and Ro 31-8220.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-194	kininogen 1	Homo sapiens	5-7
9822674-3	1998	Both BK-induced stimulation of DNA synthesis and activation of MAPK in response to BK were abolished by two different inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY 294002, as well as by two different inhibitors of protein kinase C (PKC), bisindolylmaleimide and Ro 31-8220.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-194	kininogen 1	Homo sapiens	83-85
9820515-3	1998	We report herein that inhibition of PI3K activity with the specific inhibitors LY294002 and wortmannin markedly decreased EMT activation induced by CD28 cross-linking but not by CD3 cross-linking.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	IL2 inducible T cell kinase	Homo sapiens	122-125
9820515-3	1998	We report herein that inhibition of PI3K activity with the specific inhibitors LY294002 and wortmannin markedly decreased EMT activation induced by CD28 cross-linking but not by CD3 cross-linking.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	CD28 molecule	Homo sapiens	148-152
9794429-3	1998	The Ag-induced JNK activation was inhibited by the phosphatidylinositol 3-kinase inhibitors wortmannin (10-100 nM) and LY 294002 (100 microM) but not by the protein kinase C inhibitors calphostin C (1 and 3 microM) and Ro 31-8425 (1 and 3 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	119-128	mitogen-activated protein kinase 8	Rattus norvegicus	15-18
9792703-7	1998	PI 3-kinase inhibitors such as wortmannin and LY294002, and rapamycin, an inhibitor of FRAP/TOR, cause a decline in the level of D-cyclins, whereas inhibitors of mitogen-activated protein kinase kinase and farnesyltransferase do not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	mechanistic target of rapamycin kinase	Homo sapiens	87-91
9802974-9	1998	In vitro we demonstrated that IL-5 stimulates the selective chemokinesis of bone marrow eosinophils, a process markedly inhibited by two structurally distinct inhibitors of phosphatidylinositol 3-kinase, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	219-227	interleukin-5	Cavia porcellus	30-34
9786998-5	1998	Further downstream along the signal transduction pathway, c-JUN phosphorylation occurred in both immature and mature DRG neurons after NGF withdrawal or treatment with LY294002, despite the fact that the older neurons did not undergo apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-63
9798915-7	1998	Treatment with LY294002 completely abolished the GDNF-induced increases of dopamine uptake and morphological differentiation of tyrosine hydroxylase-immunoreactive neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	glial cell derived neurotrophic factor	Homo sapiens	49-53
9786887-8	1998	Specific inhibitors of PI3-kinase (wortmannin and LY294002) induced dedifferentiation of smooth muscle cells even when they were cultured on laminin under IGF-I-stimulated conditions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	insulin like growth factor 1	Homo sapiens	155-160
9774384-2	1998	Indeed, LY294002 and wortmannin prevented the effect of PECAM-1/CD31 cross-linking on cell adhesion, at concentrations known to inhibit PI3K without affecting other kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	platelet and endothelial cell adhesion molecule 1	Homo sapiens	56-63
9808840-7	1998	RESULTS: The fibroblastic morphology induced by FGF-2 reverted to a polygonal shape in cells treated with anti-FGF-2 antibody, anti-phosphatidylinositol 3-kinase antibody, LY294002, and genistein, while anti-phospholipase C gamma1 antibody did not to reverse the modulated cell morphology.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	fibroblast growth factor 2	Homo sapiens	48-53
9808840-8	1998	Cell proliferation mediated by FGF-2 was blocked by metabolic inhibitors (genistein, LY294002 and wortmannin); genistein inhibited FGF-mediated cell proliferation in a dose-response manner and had a maximum inhibition of 80% at 100 microM, while inhibitors of phosphatidylinositol 3-kinase had less inhibitory effect than did genistein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	fibroblast growth factor 2	Homo sapiens	31-36
9808840-8	1998	Cell proliferation mediated by FGF-2 was blocked by metabolic inhibitors (genistein, LY294002 and wortmannin); genistein inhibited FGF-mediated cell proliferation in a dose-response manner and had a maximum inhibition of 80% at 100 microM, while inhibitors of phosphatidylinositol 3-kinase had less inhibitory effect than did genistein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	fibroblast growth factor 2	Homo sapiens	31-34
9790996-7	1998	Treatment of Sol8 cells with the PI3-kinase inhibitor LY294002 prevented the expression of myogenin as effectively as the increase in Akt-2 content induced by low-serum conditions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	myogenin	Mus musculus	91-99
9790996-7	1998	Treatment of Sol8 cells with the PI3-kinase inhibitor LY294002 prevented the expression of myogenin as effectively as the increase in Akt-2 content induced by low-serum conditions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	thymoma viral proto-oncogene 2	Mus musculus	134-139
9774384-2	1998	Indeed, LY294002 and wortmannin prevented the effect of PECAM-1/CD31 cross-linking on cell adhesion, at concentrations known to inhibit PI3K without affecting other kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	platelet and endothelial cell adhesion molecule 1	Homo sapiens	64-68
9748273-6	1998	PD098059 did not alter the IGF-I suppressive effect on stressor-induced JNK activity, but LY 294002 suppressed the IGF-I effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-99	insulin like growth factor 1	Homo sapiens	115-120
9786961-5	1998	HGF/SF-induced branching was abrogated by the PI3 kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	hepatocyte growth factor	Mus musculus	0-6
9788439-6	1998	In contrast, the PI 3-kinase inhibitor, LY294002, efficiently blocked the effect of insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	insulin	Homo sapiens	84-91
9808187-7	1998	We also demonstrate, using two specific inhibitors of PI3 kinase activity (LY294002 and wortmannin), that this activity plays a key role in the association of PLCgamma1 with PI3 kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	phospholipase C gamma 1	Homo sapiens	159-168
9748612-8	1998	Furthermore, the neuroprotective action of prosaposin was inhibited by LY294002, a specific inhibitor of PI 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	prosaposin	Rattus norvegicus	43-53
9794108-6	1998	The structurally distinct phosphatidylinositol 3-kinase inhibitors wortmannin (50-200 nmol/l) and LY294002 (50 mumol/l) attenuated both total insulin-stimulated 86Rb+ uptake as well as uptake via the Na+/K(+)-ATPase and Na+/K+/2Cl- cotransporter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	insulin	Homo sapiens	142-149
9794108-6	1998	The structurally distinct phosphatidylinositol 3-kinase inhibitors wortmannin (50-200 nmol/l) and LY294002 (50 mumol/l) attenuated both total insulin-stimulated 86Rb+ uptake as well as uptake via the Na+/K(+)-ATPase and Na+/K+/2Cl- cotransporter.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	solute carrier family 12 member 1	Homo sapiens	220-245
9766646-5	1998	The mitogenic effects of insulin, IGF-I, and IGF-II were markedly attenuated by the PI 3-kinase inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-115	insulin	Homo sapiens	25-32
9766646-5	1998	The mitogenic effects of insulin, IGF-I, and IGF-II were markedly attenuated by the PI 3-kinase inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-115	insulin like growth factor 1	Homo sapiens	34-39
9766646-5	1998	The mitogenic effects of insulin, IGF-I, and IGF-II were markedly attenuated by the PI 3-kinase inhibitor LY 294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-115	insulin like growth factor 2	Homo sapiens	45-51
9737973-4	1998	The PI3K inhibitors wortmannin and LY294002 inhibit the PDGF-induced phosphorylation of IRS-1, whereas the MEK inhibitor PD98059 was without a major effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	insulin receptor substrate 1	Mus musculus	88-93
9753611-6	1998	We find that pretreatment of PC12 cells with the PtdIns 3-kinase inhibitor wortmannin or LY294002 results in almost half inhibition of the NGF-dependent tyrosine phosphorylation of only Triton-insoluble Shc.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	nerve growth factor	Rattus norvegicus	139-142
9743587-3	1998	Moreover, phosphatidylinositol (PI) 3-kinase activity was induced by the presence of insulin in those cells, glucose uptake being precluded by PI 3-kinase inhibitors such as wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	insulin	Homo sapiens	85-92
9726983-5	1998	Similarly, the addition of wortmannin or LY294002 to cells expressing the wild-type PDGFR inhibited the release of intracellular calcium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	platelet derived growth factor receptor beta	Homo sapiens	84-89
9740019-6	1998	The antiapoptotic effect of IGF-I was completely blocked by LY294002, an inhibitor of PI 3-kinase signaling, but not by the mitogen-activated protein (MAP) kinase/extracellular signal-regulated protein kinase (ERK) activated protein kinase inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	insulin like growth factor 1	Homo sapiens	28-33
9722592-6	1998	The selective PI3K inhibitors wortmannin and LY294002 blocked phosphorylation of this site, previously shown to be necessary for Akt enzymatic activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	129-132
9710440-6	1998	The ability of LPA to act as a survival factor is mediated by the lipid kinase phosphatidylinositol 3-kinase (PI3K), since LPA activated both the p85-p110 and p110gamma isoforms of PI3K and macrophage survival was blocked completely by wortmannin or LY294002, two mechanistically dissimilar inhibitors of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	250-258	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	159-168
9721171-9	1998	RESULTS: Rapamycin and PI 3K inhibitors, wortmannin and LY294002, blocked CCK-stimulated p70 S6K activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	cholecystokinin	Rattus norvegicus	74-77
9721171-9	1998	RESULTS: Rapamycin and PI 3K inhibitors, wortmannin and LY294002, blocked CCK-stimulated p70 S6K activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	ribosomal protein S6 kinase B1	Rattus norvegicus	89-96
9721171-11	1998	Wortmannin and LY294002 dose-dependently inhibited basal and CCK-stimulated protein synthesis and also blocked insulin-stimulated protein synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cholecystokinin	Rattus norvegicus	61-64
9721171-12	1998	CCK dose-dependently increased PHAS-I phosphorylation via a rapamycin- and LY294002-sensitive pathway and decreased the amount of PHAS-I associated with eIF-4E.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	cholecystokinin	Rattus norvegicus	0-3
9721171-12	1998	CCK dose-dependently increased PHAS-I phosphorylation via a rapamycin- and LY294002-sensitive pathway and decreased the amount of PHAS-I associated with eIF-4E.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	31-37
9721171-13	1998	Rapamycin and LY294002 eliminated this effect of CCK.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	cholecystokinin	Rattus norvegicus	49-52
10086275-11	1998	Inhibition of phosphatidylinositol 3-kinase (PI3-K) activity by LY294002 or wortmannin also induces apoptosis in cerebellar granule neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	14-43
10086275-13	1998	The activity of c-Jun N-terminal kinase (JNK) increases 8 h after addition of LY294002 to high K+ medium or low K+ medium containing BDNF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	16-21
9721727-8	1998	The phosphatidylinositol 3-kinase (PI-3K) inhibitors wortmannin and LY294002 reduced nociceptin (OFQ)-stimulated MAP kinase activation, whereas inhibition of protein kinase C (PKC) activity by bisindolylmaleimide I or cellular depletion of PKC had no effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	prepronociceptin	Cricetulus griseus	85-95
9698319-5	1998	We observed that exposure to LY294002 or wortmannin, inhibitors of phosphatidylinositol (PI) 3-kinase, reduced somatic cross-sectional area, neurite outgrowth, whole-cell capacitance, IA amplitude and density (amplitude normalized to membrane area), and immunoreactivity for Kv4.2 and/or Kv4.3 (potassium channel subunits likely to be present in the channels carrying IA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	potassium voltage-gated channel, Shal-related family, member 2	Mus musculus	275-280
9698319-5	1998	We observed that exposure to LY294002 or wortmannin, inhibitors of phosphatidylinositol (PI) 3-kinase, reduced somatic cross-sectional area, neurite outgrowth, whole-cell capacitance, IA amplitude and density (amplitude normalized to membrane area), and immunoreactivity for Kv4.2 and/or Kv4.3 (potassium channel subunits likely to be present in the channels carrying IA).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	potassium voltage-gated channel, Shal-related family, member 3	Mus musculus	288-293
9671232-11	1998	The PI3-K inhibitor LY294002 (50 microM) reduced insulin-stimulated growth in MCF-10A and MDA-MB157 cell lines, whereas it did not modify insulin effect on ZR-75-1 cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	insulin	Homo sapiens	49-56
9710127-6	1998	The stimulation of Akt phosphorylation by shear stress thereby seemed to be mediated by the phosphoinositide 3-OH kinase (PI3K), as evidenced by the significant inhibition of shear stress-induced Akt phosphorylation by the PI3K inhibitors wortmannin (20 nmol/L) and Ly294002 (10 micromol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	266-274	AKT serine/threonine kinase 1	Homo sapiens	19-22
9710127-6	1998	The stimulation of Akt phosphorylation by shear stress thereby seemed to be mediated by the phosphoinositide 3-OH kinase (PI3K), as evidenced by the significant inhibition of shear stress-induced Akt phosphorylation by the PI3K inhibitors wortmannin (20 nmol/L) and Ly294002 (10 micromol/L).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	266-274	AKT serine/threonine kinase 1	Homo sapiens	196-199
9732695-0	1998	LY294002-mediated inhibition of phosphatidylinositol 3-kinase activity triggers growth inhibition and apoptosis in CD40-triggered Ramos-Burkitt lymphoma B cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	CD40 molecule	Homo sapiens	115-119
9732695-2	1998	This study investigates whether phosphatidylinositol 3-kinase (PI3-kinase), which has been reported to be intimately involved in the regulation of normal and neoplastic cell growth, plays a role in CD40-promoted Ramos-BL B cell survival and uses the selective and reversible PI3-kinase inhibitor, LY294002 (LY).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	297-305	CD40 molecule	Homo sapiens	198-202
9888505-6	1998	The sensitivities of both Raf-1 kinase and MAP-kinase stimulation by Ang II to the inhibitors of phosphoinositide kinases, wortmannin and LY 294002, suggest that inositol phospholipids may play a role in these activation events unrelated to their role in Ca2+ signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-147	v-raf-leukemia viral oncogene 1	Mus musculus	26-31
9888505-6	1998	The sensitivities of both Raf-1 kinase and MAP-kinase stimulation by Ang II to the inhibitors of phosphoinositide kinases, wortmannin and LY 294002, suggest that inositol phospholipids may play a role in these activation events unrelated to their role in Ca2+ signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-147	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	69-75
9879060-2	1998	To study postreceptor signaling events leading to insulin-stimulated glycogen synthesis in these cells, we have employed pathway-specific chemical inhibitors such as LY294002, rapamycin and PD98059 to inhibit phosphatidylinositol-3-kinase (PI3K), p70 ribosomal S6 kinase and mitogen-activated protein kinase (MAPK) kinase/MAPK, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	insulin	Homo sapiens	50-57
9668048-8	1998	Inhibitors of PI3-kinase, LY294002 and wortmannin, abolished insulin inhibition of PEPCK gene transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	83-88
9668053-2	1998	HGF/SF causes prolonged activation of both the mitogen-activated protein (MAP) kinase extracellular signal-regulated kinase 2 (ERK2) and the phosphoinositide 3-OH kinase (PI 3-kinase) target protein kinase B (PKB)/Akt; inhibition of either the MAP kinase pathway by the MAP kinase/ERK kinase inhibitor PD98059 or the PI 3-kinase pathway by LY294002 blocks HGF/SF induction of scattering, although in morphologically distinct ways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	340-348	hepatocyte growth factor	Canis lupus familiaris	0-6
9655695-3	1998	Growth induced by a maximally effective concentration of IGF-I (100 nM), measured as [3H]thymidine incorporation, was only partially inhibited by LY-294002 [phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor] or PD-98059 [mitogen-activated protein (MAP) kinase kinase (MEK) inhibitor] (86 +/- 7% and 35 +/- 6% inhibition, respectively) alone but was abolished by the two combined (114 +/- 18% inhibition), implying the participation of both pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-155	insulin like growth factor 1	Homo sapiens	57-62
9648866-8	1998	The neurotrophic response of IGF-1 was also inhibited by the PI 3-kinase inhibitor LY294002, the protein kinase C inhibitor chelerythrine chloride, and the protein kinase A inhibitor KT5720, but unaffected by the mitogen-activated protein kinase kinase inhibitor PD 98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	insulin like growth factor 1	Homo sapiens	29-34
9668048-8	1998	Inhibitors of PI3-kinase, LY294002 and wortmannin, abolished insulin inhibition of PEPCK gene transcription.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	insulin	Homo sapiens	61-68
9879060-3	1998	LY294002 (50 microM) completely abolished insulin-stimulated glycogen synthesis whereas rapamycin (2-20 nM) partially inhibited it.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin	Homo sapiens	42-49
9879060-7	1998	LY294002, but neither rapamycin nor PD98059, abolished insulin-induced inactivation of GSK3 alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin	Homo sapiens	55-62
9879060-7	1998	LY294002, but neither rapamycin nor PD98059, abolished insulin-induced inactivation of GSK3 alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 alpha	Rattus norvegicus	87-97
9614103-5	1998	Similarly, using well characterized inhibitors of phosphatidylinositol 3-kinase, wortmannin and LY 294002, we show that PI 3-kinase activity is necessary for the induction of G6PDH expression by insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-105	glucose-6-phosphate dehydrogenase	Rattus norvegicus	175-180
9645369-5	1998	The formation of lamellipodia by IL-2 is blocked by wortmannin and LY294002, two inhibitors of phosphoinositide 3-kinase (PI3-kinase).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	67-75	interleukin 2	Mus musculus	33-37
9603913-7	1998	The phosphatidylinositol 3"-kinase (PI3"-K) inhibitors wortmannin and LY294002 totally blocked the HGF-induced invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	4-34
9603913-7	1998	The phosphatidylinositol 3"-kinase (PI3"-K) inhibitors wortmannin and LY294002 totally blocked the HGF-induced invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	hepatocyte growth factor	Homo sapiens	99-102
9603199-5	1998	LY294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one], a potent inhibitor of PI 3-kinase, produced a dose-dependent inhibition of catecholamine secretion evoked by various secretagogues.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	peptidase inhibitor 3	Homo sapiens	83-87
9603199-5	1998	LY294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one], a potent inhibitor of PI 3-kinase, produced a dose-dependent inhibition of catecholamine secretion evoked by various secretagogues.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-58	peptidase inhibitor 3	Homo sapiens	83-87
9578588-8	1998	Treatment of CHO-HIR cells with VS resulted in increased glycogen synthesis and PI3-k activity which were blocked by pretreatment of the cells with wortmannin and LY294002, two specific inhibitors of PI3-k. On the other hand, PD98059 and rapamycin, specific inhibitors of the MAP kinase pathway and p70s6k, respectively, were unable to inhibit VS-stimulated glycogen synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	ribosomal protein S6 kinase B1	Homo sapiens	299-305
9535837-11	1998	Insulin caused a 1.7-fold increase in the endocytic degradation of 125I-AGE-BSA by these cells, the effect of which was also inhibited by wortmannin and LY294002, another PI3 kinase inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	insulin	Cricetulus griseus	0-7
9581687-7	1998	Inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin (50 nmol/L), or Ly 294002 (20 micromol/L) also prevented the cytoprotective effect of cAMP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-88	cathelicidin antimicrobial peptide	Rattus norvegicus	149-153
9572301-8	1998	In the case of Erk, activation was partially blocked by wortmannin or LY294002, indicating a possible link with PI 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	mitogen-activated protein kinase 1	Homo sapiens	15-18
9526010-4	1998	Cell death caused by LY294002 resembles death caused by NGF deprivation in that it is blocked by a caspase inhibitor or a cAMP analog and that it is accompanied by the induction of c-jun, c-fos, and cyclin D1 mRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	188-193
9526010-4	1998	Cell death caused by LY294002 resembles death caused by NGF deprivation in that it is blocked by a caspase inhibitor or a cAMP analog and that it is accompanied by the induction of c-jun, c-fos, and cyclin D1 mRNAs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	cyclin D1	Rattus norvegicus	199-208
10200474-4	1998	LY294002, another PI-3K inhibitor, also enhances Caspase-3-like activity, but inhibitors for myosin light chain kinase and calmodulin dependent kinase do not have any effect on the Caspase-3-like activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	caspase 3	Homo sapiens	49-58
9550703-7	1998	This translocation is blocked by the PI(4,5)P2 3-kinase (PI 3-kinase) inhibitors wortmannin and LY294002, and by co-expression with a dominant-negative p85 mutant, suggesting that the translocation is a consequence of insulin stimulation of PI 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	extracellular matrix protein 1	Mus musculus	152-155
9489713-4	1998	Furthermore, phosphorylation of FAK and paxillin could be prevented by addition of either wortmannin or LY-294002, under conditions in which the synthesis of phosphatidylinositol 4-phosphate was markedly attenuated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-113	protein tyrosine kinase 2	Homo sapiens	32-35
9575821-3	1998	Functionally, a specific inhibitor of PI 3-kinase, LY-294002, blocks basal as well as insulin-stimulated sodium transport in a dose-dependent manner (IC50 approximately 6 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-60	insulin	Homo sapiens	86-93
9556069-7	1998	Both WT (100 or 500 nM) and LY294002 (100 microM), a specific PI3K inhibitor structurally unrelated to WT, significantly inhibited osteoclast chemotaxis in response to M-CSF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	colony stimulating factor 1	Rattus norvegicus	168-173
9489713-4	1998	Furthermore, phosphorylation of FAK and paxillin could be prevented by addition of either wortmannin or LY-294002, under conditions in which the synthesis of phosphatidylinositol 4-phosphate was markedly attenuated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	104-113	paxillin	Homo sapiens	40-48
9461517-6	1998	This C1q-induced chemotaxis could be abolished by an inhibitor of G-proteins (pertussis toxin) and PtdIns(3,4,5)P3 kinase (wortmannin and LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	138-146	complement C1q A chain	Homo sapiens	5-8
9488489-5	1998	The PI 3-kinase inhibitors wortmannin and LY294002 inhibit the CD5-induced response as assessed in interleukin-2 (IL-2) secretion experiments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	CD5 molecule	Homo sapiens	63-66
9488489-5	1998	The PI 3-kinase inhibitors wortmannin and LY294002 inhibit the CD5-induced response as assessed in interleukin-2 (IL-2) secretion experiments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	interleukin 2	Homo sapiens	99-112
9488489-5	1998	The PI 3-kinase inhibitors wortmannin and LY294002 inhibit the CD5-induced response as assessed in interleukin-2 (IL-2) secretion experiments.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	interleukin 2	Homo sapiens	114-118
9469452-2	1998	The specific PI 3-K inhibitors wortmannin and LY294002 inhibited neutrophil homotypic aggregation stimulated by chemoattractants such as FMLP (50% inhibitory concentration (IC50) approximately 11 nM and 13 microM, respectively) but not PMA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	formyl peptide receptor 1	Homo sapiens	137-141
9446605-5	1998	We also show that insulin antiapoptotic signaling but not insulin activation of NF-kappaB involved phosphatidylinositol 3-kinase (PI 3-kinase), as supported by the inhibition of the former but not of the latter process by the PI 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	248-256	insulin	Cricetulus griseus	18-25
9570559-9	1998	Inhibition of IGF-I-inducible PI 3-kinase with either wortmannin or LY294002 abrogated the IGF-I-induced activation of PKC-zeta and totally blocked the enhancement in macrophage differentiation caused by IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	insulin like growth factor 1	Homo sapiens	14-19
9570559-9	1998	Inhibition of IGF-I-inducible PI 3-kinase with either wortmannin or LY294002 abrogated the IGF-I-induced activation of PKC-zeta and totally blocked the enhancement in macrophage differentiation caused by IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	peptidase inhibitor 3	Homo sapiens	30-34
9570559-9	1998	Inhibition of IGF-I-inducible PI 3-kinase with either wortmannin or LY294002 abrogated the IGF-I-induced activation of PKC-zeta and totally blocked the enhancement in macrophage differentiation caused by IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	insulin like growth factor 1	Homo sapiens	91-96
9570559-9	1998	Inhibition of IGF-I-inducible PI 3-kinase with either wortmannin or LY294002 abrogated the IGF-I-induced activation of PKC-zeta and totally blocked the enhancement in macrophage differentiation caused by IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	protein kinase C zeta	Homo sapiens	119-127
9570559-9	1998	Inhibition of IGF-I-inducible PI 3-kinase with either wortmannin or LY294002 abrogated the IGF-I-induced activation of PKC-zeta and totally blocked the enhancement in macrophage differentiation caused by IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	insulin like growth factor 1	Homo sapiens	91-96
9498822-0	1998	G1 phase arrest by the phosphatidylinositol 3-kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal melanoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-72	cyclin dependent kinase inhibitor 1B	Homo sapiens	107-114
9498822-0	1998	G1 phase arrest by the phosphatidylinositol 3-kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal melanoma cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-72	cyclin dependent kinase 2	Homo sapiens	136-140
9498822-5	1998	We report that the LY 294002-induced G1 arrest is closely correlated to inhibition of CDK4 and CDK2 activities leading to the impairment of pRb phosphorylation which normally occurs during G1 progression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	cyclin dependent kinase 4	Homo sapiens	86-90
9498822-5	1998	We report that the LY 294002-induced G1 arrest is closely correlated to inhibition of CDK4 and CDK2 activities leading to the impairment of pRb phosphorylation which normally occurs during G1 progression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	cyclin dependent kinase 2	Homo sapiens	95-99
9498822-5	1998	We report that the LY 294002-induced G1 arrest is closely correlated to inhibition of CDK4 and CDK2 activities leading to the impairment of pRb phosphorylation which normally occurs during G1 progression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-28	RB transcriptional corepressor 1	Homo sapiens	140-143
9446654-4	1998	Wortmannin and LY294002 inhibited p85 phosphorylation; however, p110 phosphorylation was also inhibited suggesting p110 autophosphorylation on serine/threonine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	34-37
9458729-3	1998	Two inhibitors of the p70S6k signaling pathway, rapamycin and LY-294002, greatly reduced phosphorylation of p70S6k and organization of adipocytes into multicellular clusters.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-71	ribosomal protein S6 kinase B1	Rattus norvegicus	108-114
9417065-7	1998	Treatment with the PI 3-kinase inhibitors wortmannin and LY294002 blocked both anchorage-independent growth and growth in low serum media and also resulted in morphological reversion of EGFRvIII-transformed cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	19-23
9821861-5	1998	Withdrawal of these growth factors or inhibition of PI3-kinase with wortmannin or LY294002 activated the pro-apoptotic CPP32 (Yama/Apopain/caspase 3, EC 3.4.22), activated neutral sphingomyelinase and increased ceramide formation in an immortalized dorsal root ganglion cell line F-11.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	caspase 3	Mus musculus	119-124
9821861-5	1998	Withdrawal of these growth factors or inhibition of PI3-kinase with wortmannin or LY294002 activated the pro-apoptotic CPP32 (Yama/Apopain/caspase 3, EC 3.4.22), activated neutral sphingomyelinase and increased ceramide formation in an immortalized dorsal root ganglion cell line F-11.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	caspase 3	Mus musculus	126-130
9821861-5	1998	Withdrawal of these growth factors or inhibition of PI3-kinase with wortmannin or LY294002 activated the pro-apoptotic CPP32 (Yama/Apopain/caspase 3, EC 3.4.22), activated neutral sphingomyelinase and increased ceramide formation in an immortalized dorsal root ganglion cell line F-11.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	caspase 3	Mus musculus	131-138
9821861-5	1998	Withdrawal of these growth factors or inhibition of PI3-kinase with wortmannin or LY294002 activated the pro-apoptotic CPP32 (Yama/Apopain/caspase 3, EC 3.4.22), activated neutral sphingomyelinase and increased ceramide formation in an immortalized dorsal root ganglion cell line F-11.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	caspase 3	Mus musculus	139-148
9458729-3	1998	Two inhibitors of the p70S6k signaling pathway, rapamycin and LY-294002, greatly reduced phosphorylation of p70S6k and organization of adipocytes into multicellular clusters.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	62-71	ribosomal protein S6 kinase B1	Rattus norvegicus	22-28
9458729-6	1998	Furthermore, stimulation of p70S6k phosphorylation by amino acids was prevented by either rapamycin or LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-112	ribosomal protein S6 kinase B1	Rattus norvegicus	28-34
9388205-3	1997	Wortmannin and LY 294002, two structurally distinct PI 3-K inhibitors, prevent insulin-dependent inhibition of apoB secretion in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-24	apolipoprotein B	Rattus norvegicus	111-115
9485186-6	1998	First we tested the effect of two pharmacological PI 3-kinase inhibitors, wortmannin and LY294002, on CD95 agonistic antibody-induced apoptosis in three different cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	Fas cell surface death receptor	Homo sapiens	102-106
9419414-7	1997	The inhibitory response of CR-1 in HC-11 cells on beta-casein expression after treatment with DIP can be attenuated by B581, a peptidomimetic farnesyltransferase inhibitor that blocks p21ras farnesylation and activation, and by the phosphatidylinositol 3"-kinase (PI3k) inhibitor LY 294002 but not by PD 98059, a MAPK kinase inhibitor that blocks MAPK activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	280-289	teratocarcinoma-derived growth factor 1	Mus musculus	27-31
9434772-5	1997	The mTOR autokinase and the protein kinase activity of the p110 alpha isoform of PI 3-kinase shared several notable similarities; (a) both were maximally active in the presence of Mn2+ but also showed significant activity in the presence of Mg2+ (b) neither were inhibited by the presence of non-ionic detergent and (c) both were inhibited by wortmannin and LY294002, known inhibitors of the PI 3-kinase lipid kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	358-366	mechanistic target of rapamycin kinase	Homo sapiens	4-8
9434772-5	1997	The mTOR autokinase and the protein kinase activity of the p110 alpha isoform of PI 3-kinase shared several notable similarities; (a) both were maximally active in the presence of Mn2+ but also showed significant activity in the presence of Mg2+ (b) neither were inhibited by the presence of non-ionic detergent and (c) both were inhibited by wortmannin and LY294002, known inhibitors of the PI 3-kinase lipid kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	358-366	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	59-69
9371727-3	1997	Here we show that v-Src-induced neurite outgrowth is suppressed by the selective PtdIns 3-kinase inhibitor LY294002, suggesting that this effect of v-Src in PC12 cells also requires the activity of the lipid kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	20-23
9371727-3	1997	Here we show that v-Src-induced neurite outgrowth is suppressed by the selective PtdIns 3-kinase inhibitor LY294002, suggesting that this effect of v-Src in PC12 cells also requires the activity of the lipid kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	150-153
9388270-5	1997	In contrast, all of the observed stimulatory effects of IGF-I on cell cycle progression, cyclin D1 synthesis, and pRb hyperphosphorylation were blocked by the specific phosphatidylinositol 3-kinase inhibitor LY294002, suggesting that phosphatidylinositol 3-kinase activity but not MAPK activity is required for transduction of the mitogenic IGF-I signal in MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	insulin like growth factor 1	Homo sapiens	56-61
9388270-5	1997	In contrast, all of the observed stimulatory effects of IGF-I on cell cycle progression, cyclin D1 synthesis, and pRb hyperphosphorylation were blocked by the specific phosphatidylinositol 3-kinase inhibitor LY294002, suggesting that phosphatidylinositol 3-kinase activity but not MAPK activity is required for transduction of the mitogenic IGF-I signal in MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	cyclin D1	Homo sapiens	89-98
9388270-5	1997	In contrast, all of the observed stimulatory effects of IGF-I on cell cycle progression, cyclin D1 synthesis, and pRb hyperphosphorylation were blocked by the specific phosphatidylinositol 3-kinase inhibitor LY294002, suggesting that phosphatidylinositol 3-kinase activity but not MAPK activity is required for transduction of the mitogenic IGF-I signal in MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	RB transcriptional corepressor 1	Homo sapiens	114-117
9389501-6	1997	The PI-3 kinase inhibitors, wortmannin and LY294002, completely blocked the inhibition of ErbB3 protein expression by insulin, suggesting a role for PI-3 kinase in the regulation of this growth factor receptor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	erb-b2 receptor tyrosine kinase 3	Homo sapiens	90-95
9389501-6	1997	The PI-3 kinase inhibitors, wortmannin and LY294002, completely blocked the inhibition of ErbB3 protein expression by insulin, suggesting a role for PI-3 kinase in the regulation of this growth factor receptor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	insulin	Homo sapiens	118-125
9374484-4	1997	Insulin-induced activation of immunoprecipitable PKC-zeta was inhibited by LY294002 and wortmannin; this suggested dependence upon phosphatidylinositol (PI) 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	protein kinase C, zeta	Rattus norvegicus	49-57
9460655-5	1997	Our data indicated that, in PRL treated cells, co-precipitation of PI3-kinase with anti-fyn antiserum led to time and dose-dependent activation of PI3-kinase in vitro and that this activation was blocked by the addition of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	223-231	prolactin	Rattus norvegicus	28-31
9460655-5	1997	Our data indicated that, in PRL treated cells, co-precipitation of PI3-kinase with anti-fyn antiserum led to time and dose-dependent activation of PI3-kinase in vitro and that this activation was blocked by the addition of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	223-231	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	88-91
9394803-5	1997	Pretreatment of serum-starved Jurkat cells with 100 nM wortmannin (WT) or 10 microM LY294002, two unrelated pharmacological inhibitors of PI 3-K, markedly suppressed the catalytic activity of both PI 3-K and Akt/PKB in Jurkat cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Homo sapiens	208-215
9367837-2	1997	In difluoromethylornithine-resistant L1210 cells stimulated to growth from quiescence, treatment with LY294002 inhibited cell growth and provoked a complete block of the induction of ODC activity (IC50 approximately 2 microM) and ODC protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	ornithine decarboxylase, structural 1	Mus musculus	183-186
9348199-3	1997	We found that insulin increased the enzyme activity of immunoprecipitable PKC-zeta in L6 myotubes, and this effect was blocked by PI 3-kinase inhibitors, wortmannin and LY294002; this suggested that PKC-zeta operates downstream of PI 3-kinase during insulin action.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	protein kinase C zeta	Homo sapiens	74-82
9348199-3	1997	We found that insulin increased the enzyme activity of immunoprecipitable PKC-zeta in L6 myotubes, and this effect was blocked by PI 3-kinase inhibitors, wortmannin and LY294002; this suggested that PKC-zeta operates downstream of PI 3-kinase during insulin action.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	protein kinase C zeta	Homo sapiens	199-207
9367837-2	1997	In difluoromethylornithine-resistant L1210 cells stimulated to growth from quiescence, treatment with LY294002 inhibited cell growth and provoked a complete block of the induction of ODC activity (IC50 approximately 2 microM) and ODC protein.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	ornithine decarboxylase, structural 1	Mus musculus	230-233
9325324-5	1997	In the absence of insulin, wortmannin or LY294002 enhance C/EBPalpha phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	CCAAT enhancer binding protein alpha	Homo sapiens	58-68
9349598-5	1997	Wortmannin and LY294002 did block insulin stimulation of protein kinase-B (PKB) phosphorylation and stimulation of 3-o-methylglucose transport was inhibited by wortmannin (IC50 approximately 100 nmol/l).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	insulin	Homo sapiens	34-41
9362335-7	1997	The ability of LPA to act as both a survival factor and a mitogen is mediated by the lipid kinase phosphatidylinositol 3-kinase (PI3K), since these activities were completely blocked by wortmannin or LY-294002, two structurally dissimilar inhibitors of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-209	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	98-127
9349598-5	1997	Wortmannin and LY294002 did block insulin stimulation of protein kinase-B (PKB) phosphorylation and stimulation of 3-o-methylglucose transport was inhibited by wortmannin (IC50 approximately 100 nmol/l).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	protein tyrosine kinase 2 beta	Homo sapiens	57-73
9349598-5	1997	Wortmannin and LY294002 did block insulin stimulation of protein kinase-B (PKB) phosphorylation and stimulation of 3-o-methylglucose transport was inhibited by wortmannin (IC50 approximately 100 nmol/l).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	protein tyrosine kinase 2 beta	Homo sapiens	75-78
9242178-9	1997	LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3-K) activity, inhibited PE-stimulated increases in p70S6K activity and the incorporation of labeled precursors into myocyte protein and RNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	34-63
9310372-4	1997	On the other hand, inhibitors of phosphatidylinositol PtdIns 3"-kinase (PtdIns 3"-kinase), i.e. wortmannin and LY294002, inhibited SCF-induced PLD activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	KIT ligand	Homo sapiens	131-134
9310372-4	1997	On the other hand, inhibitors of phosphatidylinositol PtdIns 3"-kinase (PtdIns 3"-kinase), i.e. wortmannin and LY294002, inhibited SCF-induced PLD activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	143-146
9312025-3	1997	These effects were abrogated by co-expression of kinase-deficient PKC zeta and inhibition of phosphatidylinositol 3-kinase p85alpha-p110 by wortmannin, LY294002 and a dominant-negative mutant of p85alpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	123-131
9287347-4	1997	Although phosphatidylinositol 3"-kinase was not activated in the FGF-2 treated cells, as judged from in vitro and in vivo analyses, wortmannin and LY294002 treatment inhibited p70(s6k) activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	ribosomal protein S6 kinase B1	Rattus norvegicus	176-183
9341793-7	1997	It was also shown, using different inhibitors of the PI3-kinase (wortmannin, Ly294002 and antisense oligonucleotides), that this lipid kinase was necessary for the down-regulation of LFA-1-mediated adhesion induced by gp160.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	integrin subunit alpha L	Homo sapiens	183-188
9341793-7	1997	It was also shown, using different inhibitors of the PI3-kinase (wortmannin, Ly294002 and antisense oligonucleotides), that this lipid kinase was necessary for the down-regulation of LFA-1-mediated adhesion induced by gp160.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	glutamyl aminopeptidase	Homo sapiens	218-223
9337861-9	1997	The catalytic activity of PI3-K-C2 alpha is refractory to concentrations of wortmannin and LY294002 which inhibit the PI3-K activity of other family members.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	26-40
9252422-9	1997	The glucose-stimulated activation of IUF1 DNA binding and MAPKAP kinase-2 (but not the arsenite-induced activation of these proteins) was prevented by wortmannin and LY 294002 at concentrations similar to those that inhibit phosphatidylinositide 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-175	pancreatic and duodenal homeobox 1	Homo sapiens	37-41
9252422-9	1997	The glucose-stimulated activation of IUF1 DNA binding and MAPKAP kinase-2 (but not the arsenite-induced activation of these proteins) was prevented by wortmannin and LY 294002 at concentrations similar to those that inhibit phosphatidylinositide 3-kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-175	MAPK activated protein kinase 2	Homo sapiens	58-73
9252422-10	1997	Our results indicate that high glucose (a cellular stress) activates SAPK2 by a novel mechanism in which a wortmannin/LY 294002-sensitive component plays an essential role.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-127	mitogen-activated protein kinase 11	Homo sapiens	69-74
9242178-9	1997	LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3-K) activity, inhibited PE-stimulated increases in p70S6K activity and the incorporation of labeled precursors into myocyte protein and RNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ribosomal protein S6 kinase B1	Homo sapiens	119-125
9235956-10	1997	Insulin-induced desensitization could be prevented if a specific inhibitor of phosphatidylinositol 3-kinase (LY294002), but not an inhibitor of mitogen-activated protein kinase (PD98059), was present during the preincubation period.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	insulin	Bos taurus	0-7
9235956-11	1997	LY294002 also prevented the shift in IRS-2 molecular mass in response to prolonged incubation of cells with insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin receptor substrate 2	Bos taurus	37-42
9235956-11	1997	LY294002 also prevented the shift in IRS-2 molecular mass in response to prolonged incubation of cells with insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin	Bos taurus	108-115
9228082-3	1997	Insulin stimulation of 3-O-methylglucose transport was inhibited by the PI 3-kinase inhibitor LY294002 (IC50 = 2.5 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	insulin	Homo sapiens	0-7
9234699-4	1997	The PI 3-kinase inhibitors wortmannin and LY294002 significantly decreased the integrin-induced accumulation of the 3-PPIs and activation of AKT kinase, without having significant effects on the levels of PI(4,5)P2 or tyrosine phosphorylation of paxillin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	42-50	AKT serine/threonine kinase 1	Homo sapiens	141-144
9234699-6	1997	Interestingly, integrin-mediated Erk-2, Mek-1, and Raf-1 activation, but not Ras-GTP loading, was inhibited at least 80% by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	mitogen-activated protein kinase 1	Homo sapiens	33-38
9234699-6	1997	Interestingly, integrin-mediated Erk-2, Mek-1, and Raf-1 activation, but not Ras-GTP loading, was inhibited at least 80% by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	mitogen-activated protein kinase kinase 1	Homo sapiens	40-45
9234699-6	1997	Interestingly, integrin-mediated Erk-2, Mek-1, and Raf-1 activation, but not Ras-GTP loading, was inhibited at least 80% by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	51-56
9815794-0	1997	Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	141-169
9256237-3	1997	Furthermore, a tyrosine protein kinase inhibitor, genistein, and phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002, affected the nociceptin-induced MAPK activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	prepronociceptin	Cricetulus griseus	145-155
9815794-4	1997	Wortmannin and LY294002 inhibited the kinase activity of purified DNA-PK and inactivated cellular DNA-PK kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	66-72
9815794-4	1997	Wortmannin and LY294002 inhibited the kinase activity of purified DNA-PK and inactivated cellular DNA-PK kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	98-104
9139803-2	1997	Activation of PI 3-kinase in response to IGF-I was markedly inhibited by two PI 3-kinase inhibitors (wortmannin and LY294002) in a dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	insulin-like growth factor 1	Rattus norvegicus	41-46
9202293-3	1997	We found that two PI 3-kinase inhibitors, wortmannin and LY294002, eliminated the protection NGF provided against peroxynitrite-induced apoptosis at concentrations consistent with their effectiveness as PI 3-kinase inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	nerve growth factor	Rattus norvegicus	93-96
9256168-0	1997	Effect of wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) on N-formyl-methionyl-leucyl-phenylalanine-induced phospholipase D activation in differentiated HL60 cells: possible involvement of phosphatidylinositol 3-kinase in phospholipase D activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	136-151
9256168-0	1997	Effect of wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) on N-formyl-methionyl-leucyl-phenylalanine-induced phospholipase D activation in differentiated HL60 cells: possible involvement of phosphatidylinositol 3-kinase in phospholipase D activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	136-151
9256168-0	1997	Effect of wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) on N-formyl-methionyl-leucyl-phenylalanine-induced phospholipase D activation in differentiated HL60 cells: possible involvement of phosphatidylinositol 3-kinase in phospholipase D activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	250-265
9223591-8	1997	In contrast, in the LM preparation, EGF-induced contractions were attentuated by the EGF receptor-kinase inhibitor, PD153035; the MAP-kinase-kinase (MEK) inhibitor, PD98059; the kinase C inhibitor, GF109203X; and the phosphatidylinositol 3"-kinase inhibitors, Wortmannin and LY294002; whereas ethanol-induced contractions were unaffected by these inhibitors.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	275-283	pro-epidermal growth factor	Cavia porcellus	36-39
9195953-8	1997	Preincubation of monocytes with the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitors, wortmannin or LY294002, abrogated LPS-induced activation of PKC-zeta.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	protein kinase C zeta	Homo sapiens	152-160
9139718-10	1997	Both the increases in D-3 phosphatidylinositol lipids and the increased in vitro lipid kinase activity of p85 immunoprecipitates were inhibited by wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	162-170	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	106-109
9133538-4	1997	The effect of LY294002, a structurally distinct PI3-kinase inhibitor, on the activation of Raf-1 kinase by both ligands was also examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	91-96
9133538-6	1997	One hundred micromol/l LY294002 blocked insulin-induced activation of Raf-1 kinase without affecting EGF-induced activation of this kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	insulin	Homo sapiens	40-47
9133538-6	1997	One hundred micromol/l LY294002 blocked insulin-induced activation of Raf-1 kinase without affecting EGF-induced activation of this kinase.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	70-75
9168474-7	1997	Inhibition of PI 3-kinase with wortmannin or LY294002 also inhibited secretory enhancement and cytoskeletal rearrangements mediated by Kit.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	135-138
9139803-5	1997	Moreover, the expression of the thermogenic marker uncoupling protein induced by IGF-I was also down-regulated in the presence of wortmannin/LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	insulin-like growth factor 1	Rattus norvegicus	81-86
9139803-7	1997	In addition, pretreatment of brown adipocytes with either wortmannin or LY294002, but not with rapamycin, blocked protein kinase C zeta activation by IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	insulin-like growth factor 1	Rattus norvegicus	150-155
8943224-4	1996	In addition, LY294002 and rapamycin, a specific p70(S6)-kinase inhibitor, were found to independently stimulate tyrosinase expression, thus increasing melanin synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	ubiquitin associated and SH3 domain containing, B	Mus musculus	48-62
9083073-7	1997	The phosphatidylinositol 3"-kinase inhibitors wortmannin and LY294002 prevented tyrosine phosphorylation of p130(cas) in response to platelet-derived growth factor but not in response to neuropeptides, lysophosphatidic acid, sphingosylphosphorylcholine, or phorbol 12,13-dibutyrate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	nucleolar and coiled-body phosphoprotein 1	Mus musculus	108-112
9034995-3	1997	RESULTS: Wortmannin and LY 294002, 2 selective inhibitors of PI 3-kinase, were shown to inhibit neutrophil activation induced by plasma opsonized crystals of calcium pyrophosphate dihydrate (CPPD) [both monoclinic (M) and triclinic (T) forms] and monosodium urate monohydrate (MSUM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-33	peptidase inhibitor 3	Homo sapiens	61-65
9034995-4	1997	IC50 for wortmannin or LY 294002 inhibition of crystal induced respiratory burst (measured by chemiluminescence) was about 3 nM and 0.3 microM, respectively, proving the pivotal role of PI 3-kinase in neutrophil respiratory burst activation by all 3 crystals.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-32	peptidase inhibitor 3	Homo sapiens	186-190
8955182-0	1996	IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin-resistant pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	interleukin 2	Homo sapiens	0-4
8955182-0	1996	IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin-resistant pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	13-18
8955182-5	1996	The IL-2 adhesion response is blocked by wortmannin and LY294002, inhibitors of phosphatidylinositol-3 (PI-3) kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	interleukin 2	Homo sapiens	4-8
8955182-9	1996	Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	SEC23 interacting protein	Homo sapiens	112-116
8955182-9	1996	Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	signal transducer and activator of transcription 3	Homo sapiens	182-187
8955182-9	1996	Wortmannin, LY294002, and cytochalasin E almost completely inhibit cytokine-induced tyrosine phosphorylation of p125, whereas tyrosine phosphorylation of PI-3 kinase, Janus kinases, Stat3, Stat5, and other proteins is unaffected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	signal transducer and activator of transcription 5A	Homo sapiens	189-194
8955182-11	1996	Taken together, these data suggest that 1) IL-2R ligation induces homotypic adhesion through a wortmannin/LY294002-sensitive, rapamycin-resistant pathway, 2) tyrosine kinases play a critical role in cytokine-induced adhesion, and 3) adhesion, but not mitogenesis, correlates with enhanced tyrosine phosphorylation of an as yet unidentified protein of 125 kDa.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	interleukin 2 receptor subunit alpha	Homo sapiens	43-48
9096344-3	1997	We demonstrate that phosphatidylinositol-3-kinase (PI3K) activity, as determined by inhibition using wortmannin and LY294002, is required for IL-8-induced cell migration of human neutrophils.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
9030615-7	1997	Treatment with two chemically distinct inhibitors of PI 3-kinase, wortmannin and LY294002, reduces PI 3-kinase activation by IGF-1 and inhibits its survival-promoting activity, suggesting that PI 3-kinase is necessary for IGF-1-mediated survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	insulin-like growth factor 1	Rattus norvegicus	125-130
9030615-7	1997	Treatment with two chemically distinct inhibitors of PI 3-kinase, wortmannin and LY294002, reduces PI 3-kinase activation by IGF-1 and inhibits its survival-promoting activity, suggesting that PI 3-kinase is necessary for IGF-1-mediated survival.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	insulin-like growth factor 1	Rattus norvegicus	222-227
9020132-6	1997	Furthermore, wortmannin and LY294002, two PI-3 kinase inhibitors, markedly decreased AP-1 activity induced by insulin, TPA, or TPA and insulin and inhibited JB6 promotion-sensitive cell transformation induced by TPA or TPA and insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	insulin	Homo sapiens	110-117
9020132-6	1997	Furthermore, wortmannin and LY294002, two PI-3 kinase inhibitors, markedly decreased AP-1 activity induced by insulin, TPA, or TPA and insulin and inhibited JB6 promotion-sensitive cell transformation induced by TPA or TPA and insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	insulin	Homo sapiens	135-142
9020132-6	1997	Furthermore, wortmannin and LY294002, two PI-3 kinase inhibitors, markedly decreased AP-1 activity induced by insulin, TPA, or TPA and insulin and inhibited JB6 promotion-sensitive cell transformation induced by TPA or TPA and insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	insulin	Homo sapiens	135-142
8943224-4	1996	In addition, LY294002 and rapamycin, a specific p70(S6)-kinase inhibitor, were found to independently stimulate tyrosinase expression, thus increasing melanin synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	tyrosinase	Mus musculus	112-122
8887671-6	1996	(ii) Inhibition of PI-3 kinase with wortmannin or LY294002 markedly decreased the AP-1 activity induced by insulin, EGF, or EGF and insulin in a dose-dependent manner, while wortmannin did not block UVB-induced AP-1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	insulin	Homo sapiens	107-114
8943397-7	1996	The IRS-1-dependent prevention of apoptosis is linked to the activation of PI 3"-kinase since wortmannin and LY294002, two inhibitors of PI 3"-K, partially inhibited the prevention of apoptosis mediated by IL-4 in 32D-IRS-1 cells after IL-3 withdrawal but not in 32D cells lacking IRS-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	insulin receptor substrate 1	Mus musculus	4-9
8943397-7	1996	The IRS-1-dependent prevention of apoptosis is linked to the activation of PI 3"-kinase since wortmannin and LY294002, two inhibitors of PI 3"-K, partially inhibited the prevention of apoptosis mediated by IL-4 in 32D-IRS-1 cells after IL-3 withdrawal but not in 32D cells lacking IRS-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	interleukin 4	Mus musculus	206-210
8943397-7	1996	The IRS-1-dependent prevention of apoptosis is linked to the activation of PI 3"-kinase since wortmannin and LY294002, two inhibitors of PI 3"-K, partially inhibited the prevention of apoptosis mediated by IL-4 in 32D-IRS-1 cells after IL-3 withdrawal but not in 32D cells lacking IRS-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	insulin receptor substrate 1	Mus musculus	218-223
8943397-7	1996	The IRS-1-dependent prevention of apoptosis is linked to the activation of PI 3"-kinase since wortmannin and LY294002, two inhibitors of PI 3"-K, partially inhibited the prevention of apoptosis mediated by IL-4 in 32D-IRS-1 cells after IL-3 withdrawal but not in 32D cells lacking IRS-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	interleukin 3	Mus musculus	236-240
8943397-7	1996	The IRS-1-dependent prevention of apoptosis is linked to the activation of PI 3"-kinase since wortmannin and LY294002, two inhibitors of PI 3"-K, partially inhibited the prevention of apoptosis mediated by IL-4 in 32D-IRS-1 cells after IL-3 withdrawal but not in 32D cells lacking IRS-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	insulin receptor substrate 1	Mus musculus	218-223
9183664-4	1996	Wortmannin and LY294002, two potent inhibitors of PI 3K, rescued immature B cells from CD38-mediated growth suppression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	CD38 molecule	Homo sapiens	87-91
8943387-6	1996	It was also shown, using different inhibitors of the PI3-kinase (wortmannin, Ly294002, and antisense oligonucleotides), that this lipid kinase was necessary for the down-regulation of LFA-1-mediated adhesion induced by CD4 binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	integrin subunit beta 2	Homo sapiens	184-189
8943387-6	1996	It was also shown, using different inhibitors of the PI3-kinase (wortmannin, Ly294002, and antisense oligonucleotides), that this lipid kinase was necessary for the down-regulation of LFA-1-mediated adhesion induced by CD4 binding.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	CD4 molecule	Homo sapiens	219-222
8887671-6	1996	(ii) Inhibition of PI-3 kinase with wortmannin or LY294002 markedly decreased the AP-1 activity induced by insulin, EGF, or EGF and insulin in a dose-dependent manner, while wortmannin did not block UVB-induced AP-1 activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	insulin	Homo sapiens	132-139
8806728-8	1996	LY294002, an inhibitor of PtdIns-3-kinase, inhibited DNA synthesis and cell proliferation in control cells to a greater extent than in BaP counterparts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	prohibitin 2	Rattus norvegicus	135-138
8895571-0	1996	Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	mechanistic target of rapamycin kinase	Homo sapiens	52-81
8895571-8	1996	The autokinase activity of mTOR was also sensitive to the structurally distinct PI 3-kinase inhibitor, LY294002, at concentrations (1-30 microM) nearly identical to those required for inhibition of the lipid kinase activity of the mammalian p85-p110 heterodimer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	mechanistic target of rapamycin kinase	Homo sapiens	27-31
8895571-9	1996	These studies indicate that the signaling functions of mTOR, and potentially those of other high molecular weight PI 3-kinase homologs, are directly affected by cellular treatment with wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-207	mechanistic target of rapamycin kinase	Homo sapiens	55-59
8816379-6	1996	Further studies designed to elucidate the mechanism by which wortmannin-treated T cells failed to provide B cell help indicated that wortmannin and LY294002 significantly inhibited the induction of CD40 ligand and, to a lesser extent, intercellular adhesion molecule-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	CD40 molecule	Homo sapiens	198-202
8816379-6	1996	Further studies designed to elucidate the mechanism by which wortmannin-treated T cells failed to provide B cell help indicated that wortmannin and LY294002 significantly inhibited the induction of CD40 ligand and, to a lesser extent, intercellular adhesion molecule-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	intercellular adhesion molecule 1	Homo sapiens	235-268
8816379-7	1996	These results suggest that the PI 3-kinase-signaling pathway, or other wortmannin- and LY294002-sensitive pathways, may be important for the induction of expression of crucial interaction molecules, such as CD40 ligand, on T cells and thus indicates that D-3 phosphoinositides play a pivotal role in regulating T cell-dependent B cell activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	peptidase inhibitor 3	Homo sapiens	31-35
8816379-7	1996	These results suggest that the PI 3-kinase-signaling pathway, or other wortmannin- and LY294002-sensitive pathways, may be important for the induction of expression of crucial interaction molecules, such as CD40 ligand, on T cells and thus indicates that D-3 phosphoinositides play a pivotal role in regulating T cell-dependent B cell activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	CD40 ligand	Homo sapiens	207-218
8828461-2	1996	Wortmannin and LY294002 (inhibitors of P13 kinase) both abolished the stimulation of protein synthesis by insulin or IGF-I in epitrochlearis muscle incubated in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	insulin	Homo sapiens	106-113
8828461-2	1996	Wortmannin and LY294002 (inhibitors of P13 kinase) both abolished the stimulation of protein synthesis by insulin or IGF-I in epitrochlearis muscle incubated in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	insulin like growth factor 1	Homo sapiens	117-122
8798386-6	1996	As expected for a Gi-coupled receptor, the inhibitors of phosphatidylinositol 3-kinase wortmannin and LY294002 inhibited activation of ERK2, albeit only partly (70%).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	mitogen-activated protein kinase 1	Homo sapiens	135-139
8663611-4	1996	In U937 cells, both PI 3-kinase inhibitors (wortmannin and LY294002) and etoposide activated the CPP32 apoptotic protease by cleavage to active p17 subunits.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	caspase 3	Homo sapiens	97-102
8663611-4	1996	In U937 cells, both PI 3-kinase inhibitors (wortmannin and LY294002) and etoposide activated the CPP32 apoptotic protease by cleavage to active p17 subunits.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	family with sequence similarity 72 member B	Homo sapiens	144-147
8695807-5	1996	Wortmannin and LY294002, two potent inhibitors of Pl 3-K, rescued immature B cells from CD38-mediated growth suppression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	CD38 molecule	Homo sapiens	88-92
8631827-5	1996	Furthermore, LY294002, an inhibitor of PI 3"-kinase structurally unrelated to wortmannin, also inhibited PDGF-stimulated p125FAK tyrosine phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	protein tyrosine kinase 2	Homo sapiens	121-128
8663063-8	1996	Similar results on D36 proliferation and lipopolysaccharide-stimulated monocyte inhibition by IL-10 were obtained with another phosphatidylinositol 3-kinase inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	interleukin 10	Mus musculus	94-99
8645200-4	1996	The phosphatidylinositol 3"-kinase inhibitor LY294002 completely blocked LPA-stimulated deoxyglucose uptake (IC50 approximately 2 microM).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	G protein-coupled receptor 45 L homeolog	Xenopus laevis	73-76
8630038-2	1996	PRL activated PI3-kinase was completely inhibited by LY294002 (1 microgram/ml).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	prolactin	Homo sapiens	0-3
8567635-8	1996	Using the structurally and mechanistically distinct phosphatidylinositol 3-kinase (PI 3-kinase) inhibitors, wortmannin and LY 294002, we provide further evidence supporting a role for PI 3-kinase activation in the regulation of PEPCK gene transcription by insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-132	peptidase inhibitor 3	Homo sapiens	184-188
8615773-7	1996	Pretreatment of CHRF-288 cells with either wortmannin (100 nM) or an unrelated synthetic PI 3-K inhibitor, LY294002 (50 microM), abolishes thrombin-receptor-stimulated blebbing.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	coagulation factor II, thrombin	Homo sapiens	139-147
8567635-8	1996	Using the structurally and mechanistically distinct phosphatidylinositol 3-kinase (PI 3-kinase) inhibitors, wortmannin and LY 294002, we provide further evidence supporting a role for PI 3-kinase activation in the regulation of PEPCK gene transcription by insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-132	insulin	Homo sapiens	256-263
8567635-8	1996	Using the structurally and mechanistically distinct phosphatidylinositol 3-kinase (PI 3-kinase) inhibitors, wortmannin and LY 294002, we provide further evidence supporting a role for PI 3-kinase activation in the regulation of PEPCK gene transcription by insulin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	123-132	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	228-233
7492306-6	1995	Interestingly, the same effect was seen in cells in the presence of IL-3 and Steel factor, while cells incubated in the presence of granulocyte-macrophage colony stimulating factor, and to a lesser extent, IL-5 could bypass the effect of wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	252-260	interleukin 3	Homo sapiens	68-72
7492306-6	1995	Interestingly, the same effect was seen in cells in the presence of IL-3 and Steel factor, while cells incubated in the presence of granulocyte-macrophage colony stimulating factor, and to a lesser extent, IL-5 could bypass the effect of wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	252-260	KIT ligand	Homo sapiens	77-89
7492304-4	1995	Histamine secretion was influenced 100-fold more by wortmannin than by KT7692.2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), a structurally different PI3-kinase inhibitor from wortmannin, inhibited PI3-kinase with an IC50 of 2 microM but had little effect on MLCK activity in this concentration range.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-126	WAP four-disulfide core domain 15B	Rattus norvegicus	164-167
7492304-4	1995	Histamine secretion was influenced 100-fold more by wortmannin than by KT7692.2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), a structurally different PI3-kinase inhibitor from wortmannin, inhibited PI3-kinase with an IC50 of 2 microM but had little effect on MLCK activity in this concentration range.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-126	WAP four-disulfide core domain 15B	Rattus norvegicus	212-215
7492306-6	1995	Interestingly, the same effect was seen in cells in the presence of IL-3 and Steel factor, while cells incubated in the presence of granulocyte-macrophage colony stimulating factor, and to a lesser extent, IL-5 could bypass the effect of wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	252-260	colony stimulating factor 2	Homo sapiens	132-180
7492304-4	1995	Histamine secretion was influenced 100-fold more by wortmannin than by KT7692.2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), a structurally different PI3-kinase inhibitor from wortmannin, inhibited PI3-kinase with an IC50 of 2 microM but had little effect on MLCK activity in this concentration range.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-126	myosin light chain kinase	Rattus norvegicus	273-277
7492306-6	1995	Interestingly, the same effect was seen in cells in the presence of IL-3 and Steel factor, while cells incubated in the presence of granulocyte-macrophage colony stimulating factor, and to a lesser extent, IL-5 could bypass the effect of wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	252-260	interleukin 5	Homo sapiens	206-210
7492304-7	1995	Furthermore KT7692 in combination with wortmannin and LY294002 would be a powerful tool for clarifying the involvement of PI3-kinase as distinct from that of MLCK in signal transduction systems of various cellular responses.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	WAP four-disulfide core domain 15B	Rattus norvegicus	122-125
7488161-4	1995	The binding to both peptides was inhibited by non-radiolabeled wortmannin and also by LY294002, another inhibitor of PI 3-kinases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	peptidase inhibitor 3	Homo sapiens	117-121
7492306-5	1995	Two potent inhibitors of PtdIns 3-kinase, wortmannin and LY294002, rapidly induced apoptosis in cells incubated in the presence of IL-4, at concentrations consistent with their ability to inhibit PtdIns 3-kinase activity in whole cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	interleukin 4	Homo sapiens	131-135
8529673-8	1995	However, the activation of p70S6K by PDGF (or nerve growth factor), but not the activation of mitogen-activated-protein kinase, was prevented by two structurally unrelated inhibitors of inositol phospholipid 3-kinase, wortmannin or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	232-240	ribosomal protein S6 kinase B1	Rattus norvegicus	27-33
7577804-11	1995	Another inhibitor of PI 3-kinase, LY294002, also resulted in augmentation of anti-CD28-induced IL-2 secretion by Jurkat cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	CD28 molecule	Homo sapiens	82-86
7642697-5	1995	The activity of Vps34p kinase is significantly reduced by the PI 3-kinase inhibitors wortmannin, a fungal metabolite, and LY294002, a quercetin analog (Stack, J. H., and S. D. Emr.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	16-22
7642697-12	1995	Moreover, after accumulation in the trans-Golgi network (TGN) at 20 degrees C, cathepsin D was rapidly missorted to the secretory pathway after addition of wortmannin and shifting to 37 degrees C. At concentrations that inhibited lysosomal enzyme delivery, both wortmannin and LY294002 caused a highly specific dilation of mannose 6-phosphate receptor (M6PR)-enriched vesicles of the prelysosome compartment (PLC), which swelled to approximately 1 micron within 15 min after treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	cathepsin D	Homo sapiens	79-90
7577804-11	1995	Another inhibitor of PI 3-kinase, LY294002, also resulted in augmentation of anti-CD28-induced IL-2 secretion by Jurkat cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	interleukin 2	Homo sapiens	95-99
33771483-7	2021	In this study, we found that PD-L1 induces the upregulation of CD206 expression, which is inhibited by nivolumab, LY294002, U0126, and rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	CD274 molecule	Homo sapiens	29-34
7852343-5	1995	In contrast, wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), inhibitors of phosphatidylinositol 3-kinase, antagonized glycogen synthase activation in response to insulin or IGF-I.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	insulin-like growth factor 1	Rattus norvegicus	201-206
7989323-6	1994	Characterization of the PI 3-kinase activity of Vps34p demonstrates that it, unlike the mammalian p110 PI 3-kinase, is highly resistant to the PI 3-kinase inhibitors wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	48-54
7980500-0	1994	Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	8-37
7980500-0	1994	Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	insulin receptor	Homo sapiens	41-57
7980500-3	1994	However, LY294002 partially inhibited insulin stimulated glucose uptake, amino acid uptake and protein synthesis, while it completely inhibited insulin stimulation of DNA synthesis and p70 S6 kinase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	insulin	Homo sapiens	38-45
7980500-3	1994	However, LY294002 partially inhibited insulin stimulated glucose uptake, amino acid uptake and protein synthesis, while it completely inhibited insulin stimulation of DNA synthesis and p70 S6 kinase activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	insulin	Homo sapiens	144-151
7868907-3	1995	Treatment of human neutrophils with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), a potent and specific inhibitor of Ptdlns 3-kinase, resulted in complete inhibition of Ptdlns 3-kinase activity as well as in inhibition of superoxide production in FMLP-treated neutrophils in suspension; FMLP-stimulated oxidant production in adherent cells was also abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-84	formyl peptide receptor 1	Homo sapiens	262-266
7868907-3	1995	Treatment of human neutrophils with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), a potent and specific inhibitor of Ptdlns 3-kinase, resulted in complete inhibition of Ptdlns 3-kinase activity as well as in inhibition of superoxide production in FMLP-treated neutrophils in suspension; FMLP-stimulated oxidant production in adherent cells was also abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-84	formyl peptide receptor 1	Homo sapiens	302-306
7868907-3	1995	Treatment of human neutrophils with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), a potent and specific inhibitor of Ptdlns 3-kinase, resulted in complete inhibition of Ptdlns 3-kinase activity as well as in inhibition of superoxide production in FMLP-treated neutrophils in suspension; FMLP-stimulated oxidant production in adherent cells was also abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	formyl peptide receptor 1	Homo sapiens	262-266
7868907-3	1995	Treatment of human neutrophils with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), a potent and specific inhibitor of Ptdlns 3-kinase, resulted in complete inhibition of Ptdlns 3-kinase activity as well as in inhibition of superoxide production in FMLP-treated neutrophils in suspension; FMLP-stimulated oxidant production in adherent cells was also abolished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	formyl peptide receptor 1	Homo sapiens	302-306
7528328-4	1995	Inhibition of PI3K activity with structurally unrelated but highly specific PI3K inhibitors (wortmannin or LY294002) results in inhibition of IL-2-dependent but not phorbol ester (conventional protein kinase C [cPKC])-dependent pp70S6k activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	interleukin 2	Homo sapiens	142-146
7519067-6	1993	These results show that Ly2 (CD8) molecule plays an essential role in the interaction of CTL with MHC class I molecule only if T-cell receptor has low affinity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-27	CD8a molecule	Homo sapiens	29-32
33771483-7	2021	In this study, we found that PD-L1 induces the upregulation of CD206 expression, which is inhibited by nivolumab, LY294002, U0126, and rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	mannose receptor C-type 1	Homo sapiens	63-68
31624724-17	2019	15d-PGJ2 activates Akt and a pharmacological inhibitor of Akt, LY294002, abrogated 15d-PGJ2-induced 15-PGDH expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	carbonyl reductase 1	Homo sapiens	100-107
33942537-14	2021	More importantly, the apoptosis triggered by S100A6 can be offset by the PI3K/AKT pathway inhibitor and activator (LY294002 and IGF-1), the values of Caspase-3 activity and apoptosis index became close to the untreated osteoarthritis group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	S100 calcium binding protein A6	Rattus norvegicus	45-51
33824697-10	2021	These effects of TGF-beta 1 could be inhibited by the ROS scavenger N-acetylcysteine (NAC), siRNA-mediated knockdown of Smad3 and NOX4, and pharmacological inhibitors SB203580 (p38MAPK inhibitor) and LY294002 (Akt inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	transforming growth factor, beta 1	Mus musculus	17-27
33804171-6	2021	The specific phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 triggered GSK-3beta activation and Abeta expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	13-42
33804171-6	2021	The specific phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 triggered GSK-3beta activation and Abeta expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	glycogen synthase kinase 3 alpha	Mus musculus	79-88
33804171-6	2021	The specific phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 triggered GSK-3beta activation and Abeta expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	amyloid beta (A4) precursor protein	Mus musculus	104-109
33804171-7	2021	In addition, co-treatment with LY294002 noticeably blocked the effect of dieckol on Abeta production, demonstrating that dieckol promoted the PI3K/Akt signaling pathway, which in turn inactivated GSK-3beta, resulting in the reduction in Abeta levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	amyloid beta (A4) precursor protein	Mus musculus	84-89
33804171-7	2021	In addition, co-treatment with LY294002 noticeably blocked the effect of dieckol on Abeta production, demonstrating that dieckol promoted the PI3K/Akt signaling pathway, which in turn inactivated GSK-3beta, resulting in the reduction in Abeta levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	thymoma viral proto-oncogene 1	Mus musculus	147-150
33804171-7	2021	In addition, co-treatment with LY294002 noticeably blocked the effect of dieckol on Abeta production, demonstrating that dieckol promoted the PI3K/Akt signaling pathway, which in turn inactivated GSK-3beta, resulting in the reduction in Abeta levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	glycogen synthase kinase 3 alpha	Mus musculus	196-205
33804171-7	2021	In addition, co-treatment with LY294002 noticeably blocked the effect of dieckol on Abeta production, demonstrating that dieckol promoted the PI3K/Akt signaling pathway, which in turn inactivated GSK-3beta, resulting in the reduction in Abeta levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	amyloid beta (A4) precursor protein	Mus musculus	237-242
33235618-5	2021	The aim of the present study was to explore whether LY294002, an inhibitor of PI3K, is able to improve the sensitivity of NSCLC cell lines with wild-type EGFR to the EGFR-TKI erlotinib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	epidermal growth factor receptor	Homo sapiens	154-158
33235618-5	2021	The aim of the present study was to explore whether LY294002, an inhibitor of PI3K, is able to improve the sensitivity of NSCLC cell lines with wild-type EGFR to the EGFR-TKI erlotinib.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	epidermal growth factor receptor	Homo sapiens	166-170
33235618-6	2021	An MTT assay was used to examine the effect of combined treatment with LY294002 and erlotinib on cell survival of two EGFR wild-type NSCLC cell lines, NCI-H661 and NCI-H460.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	epidermal growth factor receptor	Homo sapiens	118-122
33235618-11	2021	Furthermore, combination treatment of erlotinib and LY294002 resulted in a significant reduction of phosphorylated p70S6K levels in NCI-H661 [PI3K catalytic subunit alpha (PI3KCA) wild-type] cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	ribosomal protein S6 kinase B1	Homo sapiens	115-121
30952195-2	2019	PI3K/AKT signaling is frequently activated in GC, and its inhibitor LY294002 exerts potent antitumor effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	thymoma viral proto-oncogene 1	Mus musculus	5-8
29436581-4	2018	The downregulation of PI3K using LY294002 markedly suppressed cell viability, reduced the protein levels of FOXO3a and p27kip1, and increased TNF-alpha protein production in the LPS-induced spinal cord cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	forkhead box O3	Rattus norvegicus	108-114
29436581-4	2018	The downregulation of PI3K using LY294002 markedly suppressed cell viability, reduced the protein levels of FOXO3a and p27kip1, and increased TNF-alpha protein production in the LPS-induced spinal cord cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	119-126
29436581-4	2018	The downregulation of PI3K using LY294002 markedly suppressed cell viability, reduced the protein levels of FOXO3a and p27kip1, and increased TNF-alpha protein production in the LPS-induced spinal cord cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	tumor necrosis factor	Rattus norvegicus	142-151
26389892-2	2015	The protective effect of GA was completely abrogated by the specific phosphoinositide 3-kinase (PI3K) inhibitor LY294002, and the specific protein kinase B (Akt) inhibitor Akt VIII respectively, indicating that the protective mechanism of GA is mediated by the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	69-94
28347821-7	2017	The enhanced phospho-eNOS was inhibited by LY294002, indicating that the effects of LED-T on the ischemic brain could be attributed to the upregulation of eNOS phosphorylation through the phosphoinositide 3-kinase (PI3K)/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	188-213
28347821-7	2017	The enhanced phospho-eNOS was inhibited by LY294002, indicating that the effects of LED-T on the ischemic brain could be attributed to the upregulation of eNOS phosphorylation through the phosphoinositide 3-kinase (PI3K)/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	thymoma viral proto-oncogene 1	Mus musculus	221-224
26389892-6	2015	LY294002 completely inhibited the GA-activated phosphorylation of Akt, while only partially inhibiting eNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	66-69
34874107-5	2022	Moreover, AOF was able to protect neurons through the PI3K/AKT signaling pathway and significantly decrease NF-kappaB, IL-6, IL-1beta, and TNF-alpha levels in the hippocampal and cortex tissues, which were reversed through the use of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	thymoma viral proto-oncogene 1	Mus musculus	59-62
25351625-0	2015	LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3-kinase/Akt/fatty acid synthase signaling pathway in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	82-111
25351625-0	2015	LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3-kinase/Akt/fatty acid synthase signaling pathway in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	112-115
25351625-0	2015	LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3-kinase/Akt/fatty acid synthase signaling pathway in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	fatty acid synthase	Homo sapiens	116-135
25351625-8	2015	The results demonstrated that LY294002 suppressed the PI3K/Akt/FASN signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	59-62
25351625-8	2015	The results demonstrated that LY294002 suppressed the PI3K/Akt/FASN signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	fatty acid synthase	Homo sapiens	63-67
25351625-10	2015	The present results indicated that LY294002 inhibits the malignant phenotype of OS cells via modulation of the PI3K/Akt/FASN signaling pathway in vitro and may be a new therapeutic strategy for the management of OS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Homo sapiens	116-119
25351625-10	2015	The present results indicated that LY294002 inhibits the malignant phenotype of OS cells via modulation of the PI3K/Akt/FASN signaling pathway in vitro and may be a new therapeutic strategy for the management of OS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	fatty acid synthase	Homo sapiens	120-124
21333717-4	2011	The pro-survival capacity of SMN was assessed in an Akt/PI3-kinase inhibition (LY294002) model, as well as an oxidative stress (hydrogen peroxide) and excitotoxic (glutamate) model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	survival of motor neuron 1, telomeric	Homo sapiens	29-32
11826398-6	2002	The phosphatidylinositol 3-kinase (PI3-kinase) inhibitors wortmannin or LY294002 and rapamycin, an inhibitor of p70 S6 kinase phosphorylation, ameliorated the insulin-mediated decrease in CYP2E1 mRNA levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	188-194
21055460-9	2011	The NAC-induced increase in Cyr61 protein levels was suppressed by the PI3K inhibitor (Ly294002) and, to a lesser extent, MEK/Erk1/2 inhibitor (PD98059).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	cellular communication network factor 1	Homo sapiens	28-33
19561517-9	2009	U0126, an inhibitor of mitogen-activated protein kinase signaling, and LY294002, a phosphatidylinositol-3 kinase inhibitor, reduced MMP-1 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	matrix metallopeptidase 1	Homo sapiens	132-137
19561517-10	2009	U0126 also reduced TIMP-1 levels, but LY294002 increased TIMP-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	TIMP metallopeptidase inhibitor 1	Homo sapiens	57-63
34958867-4	2022	Here, we, for the first time, investigated that the combined inhibition of PARP by Talazoparib (TAL) and PI3K by LY294002 synergistically inhibited proliferation of BRCA1 mutant HCC1937 TNBC cells through apoptosis, G0/G1 arrest, oxidative stress and increased DNA damage compared to drug alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	poly(ADP-ribose) polymerase 1	Homo sapiens	75-79
34958867-4	2022	Here, we, for the first time, investigated that the combined inhibition of PARP by Talazoparib (TAL) and PI3K by LY294002 synergistically inhibited proliferation of BRCA1 mutant HCC1937 TNBC cells through apoptosis, G0/G1 arrest, oxidative stress and increased DNA damage compared to drug alone.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	BRCA1 DNA repair associated	Homo sapiens	165-170
34958867-6	2022	Co-treatment of TAL with LY294002 considerably suppressed the activation of PI3K, Akt1 and mTOR expression and phosphorylated protein levels in TNBC cells and caused changes in the multiple kinase phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	AKT serine/threonine kinase 1	Homo sapiens	82-86
34958867-6	2022	Co-treatment of TAL with LY294002 considerably suppressed the activation of PI3K, Akt1 and mTOR expression and phosphorylated protein levels in TNBC cells and caused changes in the multiple kinase phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	mechanistic target of rapamycin kinase	Homo sapiens	91-95
34973261-9	2022	In addition, LY294002, an inhibitor of PI3K, abolished the effect of IL-4 by inhibiting GC growth and promoting apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	interleukin 4	Homo sapiens	69-73
34874107-5	2022	Moreover, AOF was able to protect neurons through the PI3K/AKT signaling pathway and significantly decrease NF-kappaB, IL-6, IL-1beta, and TNF-alpha levels in the hippocampal and cortex tissues, which were reversed through the use of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	108-117
34874107-5	2022	Moreover, AOF was able to protect neurons through the PI3K/AKT signaling pathway and significantly decrease NF-kappaB, IL-6, IL-1beta, and TNF-alpha levels in the hippocampal and cortex tissues, which were reversed through the use of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	interleukin 6	Mus musculus	119-123
34874107-5	2022	Moreover, AOF was able to protect neurons through the PI3K/AKT signaling pathway and significantly decrease NF-kappaB, IL-6, IL-1beta, and TNF-alpha levels in the hippocampal and cortex tissues, which were reversed through the use of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	interleukin 1 alpha	Mus musculus	125-133
34874107-5	2022	Moreover, AOF was able to protect neurons through the PI3K/AKT signaling pathway and significantly decrease NF-kappaB, IL-6, IL-1beta, and TNF-alpha levels in the hippocampal and cortex tissues, which were reversed through the use of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	234-242	tumor necrosis factor	Mus musculus	139-148
34522005-6	2022	The behavioural effect of cocaine was attenuated by intra-NAc administration of LY294002, an AKT-specific inhibitor, suggesting that PIPs may contribute to mTOR activation in response to cocaine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	thymoma viral proto-oncogene 1	Mus musculus	93-96
34522005-6	2022	The behavioural effect of cocaine was attenuated by intra-NAc administration of LY294002, an AKT-specific inhibitor, suggesting that PIPs may contribute to mTOR activation in response to cocaine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	mechanistic target of rapamycin kinase	Mus musculus	156-160
34678088-8	2022	PI3K pathway inhibitor LY294002 or MEK pathway inhibitor U0126, or Warburg effect inhibitor DCA was used to carry out western blot and glucose metabolism experiments, and the results showed that PDGFBB/PDGFRbeta mainly activated the PI3K/AKT/mTOR/ c-Myc pathway to promote aerobic glycolysis in osteosarcoma HOS cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	platelet derived growth factor receptor beta	Homo sapiens	202-211
34874518-9	2022	The protective effects of XBJ were blocked by LY294002, a phosphatidylinositol 3-kinase (PI3K)/AKT/FoxO1 pathway antagonist (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	58-87
34874518-9	2022	The protective effects of XBJ were blocked by LY294002, a phosphatidylinositol 3-kinase (PI3K)/AKT/FoxO1 pathway antagonist (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	AKT serine/threonine kinase 1	Rattus norvegicus	95-98
34874518-9	2022	The protective effects of XBJ were blocked by LY294002, a phosphatidylinositol 3-kinase (PI3K)/AKT/FoxO1 pathway antagonist (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	forkhead box O1	Rattus norvegicus	99-104
34678088-8	2022	PI3K pathway inhibitor LY294002 or MEK pathway inhibitor U0126, or Warburg effect inhibitor DCA was used to carry out western blot and glucose metabolism experiments, and the results showed that PDGFBB/PDGFRbeta mainly activated the PI3K/AKT/mTOR/ c-Myc pathway to promote aerobic glycolysis in osteosarcoma HOS cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	AKT serine/threonine kinase 1	Homo sapiens	238-241
34678088-8	2022	PI3K pathway inhibitor LY294002 or MEK pathway inhibitor U0126, or Warburg effect inhibitor DCA was used to carry out western blot and glucose metabolism experiments, and the results showed that PDGFBB/PDGFRbeta mainly activated the PI3K/AKT/mTOR/ c-Myc pathway to promote aerobic glycolysis in osteosarcoma HOS cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	23-31	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	248-253
34875308-9	2022	The contribution of MEK1/2, PI3K and the transcription factor ID1 in rHDL-apoE3-induced EC migration and activation of EC migration-related effectors was assessed using specific inhibitors (PD98059: MEK1/2, LY294002: PI3K) and siRNA-mediated gene silencing, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	apolipoprotein E	Homo sapiens	74-79
34913077-8	2022	After addition of the PI3K/AKT/mTOR signaling pathway inhibitor LY294002 or activator 740Y-P, cell function analysis was performed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	AKT serine/threonine kinase 1	Homo sapiens	27-30
34875308-14	2022	In addition, rHDL-apoE3 stimulated migration of HCAEC and EA.hy926 cells, and the migration was markedly attenuated in the presence of PD98059 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	apolipoprotein E	Homo sapiens	18-23
34913077-8	2022	After addition of the PI3K/AKT/mTOR signaling pathway inhibitor LY294002 or activator 740Y-P, cell function analysis was performed.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	mechanistic target of rapamycin kinase	Homo sapiens	31-35
34875308-15	2022	rHDL-apoE3 also increased the phosphorylation of ERK1/2, AKT, eNOS and p38 MAPK in these cells, while PD98059 and LY294002 inhibited rHDL-apoE3-induced phosphorylation of ERK1/2, AKT and p38 MAPK, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	apolipoprotein E	Homo sapiens	138-143
34875308-15	2022	rHDL-apoE3 also increased the phosphorylation of ERK1/2, AKT, eNOS and p38 MAPK in these cells, while PD98059 and LY294002 inhibited rHDL-apoE3-induced phosphorylation of ERK1/2, AKT and p38 MAPK, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	mitogen-activated protein kinase 3	Homo sapiens	171-177
34875308-15	2022	rHDL-apoE3 also increased the phosphorylation of ERK1/2, AKT, eNOS and p38 MAPK in these cells, while PD98059 and LY294002 inhibited rHDL-apoE3-induced phosphorylation of ERK1/2, AKT and p38 MAPK, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	AKT serine/threonine kinase 1	Homo sapiens	179-182
34875308-15	2022	rHDL-apoE3 also increased the phosphorylation of ERK1/2, AKT, eNOS and p38 MAPK in these cells, while PD98059 and LY294002 inhibited rHDL-apoE3-induced phosphorylation of ERK1/2, AKT and p38 MAPK, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	114-122	mitogen-activated protein kinase 14	Mus musculus	187-195
34813998-5	2022	Notably, next generation pharmacogenomic analysis identified the PI3K/Akt modulator LY294002 as the most highly ranked small molecule with both pro- and anti-oligodendroglial concentration-dependent effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Homo sapiens	70-73
34935059-11	2022	Inactivation of the PI3K/Akt pathway by LY294002 or BER enhanced GEM-induced cytotoxicity and downregulated Rad51 expression, whilst overexpression of constitutively active Akt restored Rad51 expression and cell viability that was previously decreased by BER and GEM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	AKT serine/threonine kinase 1	Homo sapiens	25-28
34935059-11	2022	Inactivation of the PI3K/Akt pathway by LY294002 or BER enhanced GEM-induced cytotoxicity and downregulated Rad51 expression, whilst overexpression of constitutively active Akt restored Rad51 expression and cell viability that was previously decreased by BER and GEM.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	RAD51 recombinase	Homo sapiens	108-113
34938382-10	2021	Inhibition of mTOR by Rapamycin counteracted the combined protection of SeMet and Tau against LPS-induced inflammatory damage, the inhibition of PI3K by LY294002 blocked the activation of mTOR, and the accumulation of ROS by the ROS agonist blocked the activation of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	mechanistic target of rapamycin kinase	Mus musculus	188-192
34780922-8	2022	The addition of PI3K/AKT inhibitor LY294002 could reverse the decrease of YAP phosphorylation level and cell apoptosis, and the increase of nuclear translocation caused by P2RY2 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Rattus norvegicus	21-24
34780922-8	2022	The addition of PI3K/AKT inhibitor LY294002 could reverse the decrease of YAP phosphorylation level and cell apoptosis, and the increase of nuclear translocation caused by P2RY2 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	Yes1 associated transcriptional regulator	Rattus norvegicus	74-77
34780922-8	2022	The addition of PI3K/AKT inhibitor LY294002 could reverse the decrease of YAP phosphorylation level and cell apoptosis, and the increase of nuclear translocation caused by P2RY2 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	purinergic receptor P2Y2	Rattus norvegicus	172-177
34955724-12	2021	TFCJ reduced cell apoptosis and oxidative stress by increasing the level of p-AKT and p-mTOR in MCAO rats, while the effect of TFCJ was significantly reversed when applying LY294002 (PI3k inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
34955724-12	2021	TFCJ reduced cell apoptosis and oxidative stress by increasing the level of p-AKT and p-mTOR in MCAO rats, while the effect of TFCJ was significantly reversed when applying LY294002 (PI3k inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	mechanistic target of rapamycin kinase	Rattus norvegicus	88-92
34500338-8	2022	We observed that the expression of p-AKT was upregulated which means that the AKT signaling pathway could be activated by LIPUS, while inhibitor LY294002 of the AKT signaling pathway effectively blocked LIPUS-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	AKT serine/threonine kinase 1	Homo sapiens	37-40
34500338-8	2022	We observed that the expression of p-AKT was upregulated which means that the AKT signaling pathway could be activated by LIPUS, while inhibitor LY294002 of the AKT signaling pathway effectively blocked LIPUS-induced angiogenesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	145-153	AKT serine/threonine kinase 1	Homo sapiens	161-164
34881695-4	2021	LY 294002 treatment showed that Tau promoted ARID4B expression in a PI3K-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-9	AT rich interactive domain 4B (RBP1-like)	Mus musculus	45-51
34956168-8	2021	This was further confirmed by the finding that both inhibitors of PI3K-Akt and its main downstream signaling mTOR, LY294002, and rapamycin, respectively, can reverse the increase of IFN-gamma production and cytotoxicity in NK cells promoted by Daphnetin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	AKT serine/threonine kinase 1	Homo sapiens	71-74
34718369-10	2021	PI3K inhibitor LY294002 could eliminate the effects of PAQR4 on cell proliferation, apoptosis, chemoresistance, and invasion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	progestin and adipoQ receptor family member 4	Homo sapiens	55-60
34956168-8	2021	This was further confirmed by the finding that both inhibitors of PI3K-Akt and its main downstream signaling mTOR, LY294002, and rapamycin, respectively, can reverse the increase of IFN-gamma production and cytotoxicity in NK cells promoted by Daphnetin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	interferon gamma	Homo sapiens	182-191
34912580-11	2021	Inhibition of Akt activity by LY294002 promoted ET-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	AKT serine/threonine kinase 1	Homo sapiens	14-17
34761752-4	2021	Previous studies have reported the potential of LY294002 (LY) as a PI3K/Akt inhibitor that suppresses the HSC activation and fibrosis development; however, its poor water solubility impedes further investigation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	72-75
34761752-4	2021	Previous studies have reported the potential of LY294002 (LY) as a PI3K/Akt inhibitor that suppresses the HSC activation and fibrosis development; however, its poor water solubility impedes further investigation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	fucosyltransferase 1 (H blood group)	Homo sapiens	106-109
34761752-4	2021	Previous studies have reported the potential of LY294002 (LY) as a PI3K/Akt inhibitor that suppresses the HSC activation and fibrosis development; however, its poor water solubility impedes further investigation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-60	AKT serine/threonine kinase 1	Homo sapiens	72-75
34761752-4	2021	Previous studies have reported the potential of LY294002 (LY) as a PI3K/Akt inhibitor that suppresses the HSC activation and fibrosis development; however, its poor water solubility impedes further investigation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-60	fucosyltransferase 1 (H blood group)	Homo sapiens	106-109
34938752-8	2021	Administering LY294002, an Akt inhibitor, decreased p-mTOR levels, but did not change the levels of total and phosphorylated AMPKalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	27-30
34938752-8	2021	Administering LY294002, an Akt inhibitor, decreased p-mTOR levels, but did not change the levels of total and phosphorylated AMPKalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	mechanistic target of rapamycin kinase	Homo sapiens	54-58
34912580-11	2021	Inhibition of Akt activity by LY294002 promoted ET-1 production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	endothelin 1	Homo sapiens	48-52
34900083-20	2021	LY294002 inhibited the upregulation of NRF2 activated by BHD through inhibiting the phosphorylation of the AKT/GSK3beta pathway (P < 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-43
34653380-9	2021	An Akt pathway inhibitor, LY294002, an ERK pathway inhibitor, PD98059, an antagonist of chemokine-like receptor 1 (CMKLR1), 2-(alpha-Napththoyl) ethyltrimethylammonium iodide, or an antioxidant, N-acetyl-L-cysteine prevented the migration induced by chemerin-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	AKT serine/threonine kinase 1	Rattus norvegicus	3-6
34900083-20	2021	LY294002 inhibited the upregulation of NRF2 activated by BHD through inhibiting the phosphorylation of the AKT/GSK3beta pathway (P < 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	107-110
34900083-20	2021	LY294002 inhibited the upregulation of NRF2 activated by BHD through inhibiting the phosphorylation of the AKT/GSK3beta pathway (P < 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	glycogen synthase kinase 3 alpha	Mus musculus	111-119
34288825-9	2021	Furthermore, administration of PI3K/AKT pathway inhibitor LY294002 abolished the beneficial effects of EPH.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Rattus norvegicus	36-39
34619494-7	2021	Co-treatment with SHQA and LY294002, a specific PI3K inhibitor, inhibited nuclear Nrf2 expression and Akt phosphorylation, demonstrating that SHQA-mediated Nrf2 activation was directly associated with the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	82-86
34619494-7	2021	Co-treatment with SHQA and LY294002, a specific PI3K inhibitor, inhibited nuclear Nrf2 expression and Akt phosphorylation, demonstrating that SHQA-mediated Nrf2 activation was directly associated with the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
34619494-7	2021	Co-treatment with SHQA and LY294002, a specific PI3K inhibitor, inhibited nuclear Nrf2 expression and Akt phosphorylation, demonstrating that SHQA-mediated Nrf2 activation was directly associated with the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	156-160
34619494-7	2021	Co-treatment with SHQA and LY294002, a specific PI3K inhibitor, inhibited nuclear Nrf2 expression and Akt phosphorylation, demonstrating that SHQA-mediated Nrf2 activation was directly associated with the PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	210-213
34717965-10	2021	Notably, the neuroprotective effects of IGF-1 were blocked by an inhibitor of the PI3K/AKT cascade, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	insulin-like growth factor 1	Rattus norvegicus	40-45
34717965-10	2021	Notably, the neuroprotective effects of IGF-1 were blocked by an inhibitor of the PI3K/AKT cascade, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	AKT serine/threonine kinase 1	Rattus norvegicus	87-90
34717965-11	2021	LY294002 treatment not only downregulated PI3K and p-AKT, but YAP/TAZ as well, leading to aggravation of neurological dysfunction and worsening of brain damage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	53-56
34717965-11	2021	LY294002 treatment not only downregulated PI3K and p-AKT, but YAP/TAZ as well, leading to aggravation of neurological dysfunction and worsening of brain damage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Yes1 associated transcriptional regulator	Rattus norvegicus	62-65
34717965-11	2021	LY294002 treatment not only downregulated PI3K and p-AKT, but YAP/TAZ as well, leading to aggravation of neurological dysfunction and worsening of brain damage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tafazzin, phospholipid-lysophospholipid transacylase	Rattus norvegicus	66-69
34425525-10	2021	LY294002 was used to block the PI3K/AKT/mTOR signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	36-39
34224057-9	2021	Further studies demonstrated that MGC27382-mediated inhibition on NSCLC progression can be impaired by LY294002, which is a frequently used inhibitor of AKT/GSK3beta pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	AKT serine/threonine kinase 1	Homo sapiens	153-156
34224057-9	2021	Further studies demonstrated that MGC27382-mediated inhibition on NSCLC progression can be impaired by LY294002, which is a frequently used inhibitor of AKT/GSK3beta pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	glycogen synthase kinase 3 alpha	Homo sapiens	157-165
34425525-10	2021	LY294002 was used to block the PI3K/AKT/mTOR signalling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mechanistic target of rapamycin kinase	Mus musculus	40-44
34715758-9	2021	Meanwhile, LY294002 attenuated the inhibitory effects of ephedrine on NLRP3 inflammasome activation and TNF-alpha and IL-1beta production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	NLR family, pyrin domain containing 3	Mus musculus	70-75
34632857-8	2021	At the gene level, IGF-1 inhibition of PBDE-209-induced cell cytotoxicity was through the activation of the PI3K/AKT and MEK/ERK signaling pathways in vitro because the effect of IGF-1 was blocked by the AKT inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	insulin-like growth factor 1	Rattus norvegicus	19-24
34715758-9	2021	Meanwhile, LY294002 attenuated the inhibitory effects of ephedrine on NLRP3 inflammasome activation and TNF-alpha and IL-1beta production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	tumor necrosis factor	Mus musculus	104-113
34632857-8	2021	At the gene level, IGF-1 inhibition of PBDE-209-induced cell cytotoxicity was through the activation of the PI3K/AKT and MEK/ERK signaling pathways in vitro because the effect of IGF-1 was blocked by the AKT inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	AKT serine/threonine kinase 1	Rattus norvegicus	113-116
34632857-8	2021	At the gene level, IGF-1 inhibition of PBDE-209-induced cell cytotoxicity was through the activation of the PI3K/AKT and MEK/ERK signaling pathways in vitro because the effect of IGF-1 was blocked by the AKT inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	Eph receptor B1	Rattus norvegicus	125-128
34715758-9	2021	Meanwhile, LY294002 attenuated the inhibitory effects of ephedrine on NLRP3 inflammasome activation and TNF-alpha and IL-1beta production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	interleukin 1 alpha	Mus musculus	118-126
34632857-8	2021	At the gene level, IGF-1 inhibition of PBDE-209-induced cell cytotoxicity was through the activation of the PI3K/AKT and MEK/ERK signaling pathways in vitro because the effect of IGF-1 was blocked by the AKT inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	insulin-like growth factor 1	Rattus norvegicus	179-184
34632857-8	2021	At the gene level, IGF-1 inhibition of PBDE-209-induced cell cytotoxicity was through the activation of the PI3K/AKT and MEK/ERK signaling pathways in vitro because the effect of IGF-1 was blocked by the AKT inhibitor LY294002 and the ERK1/2 inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	218-226	AKT serine/threonine kinase 1	Rattus norvegicus	204-207
34741867-7	2021	To dissect the signaling pathway leading to SGK1 upregulation, we pretreated THP-1-derived macrophages with specific inhibitors of Notch (DAPT), AKT (LY294002) or ERK (U0126).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	serum/glucocorticoid regulated kinase 1	Homo sapiens	44-48
34448677-3	2021	The rats were treated with stevioside treatment, PPAR-gamma antagonist GW9662, PPAR-gamma activator pioglitazone or PI3K/AKT inhibitor LY294002 before neurological deficits were assessed using modified Neurological Severity Scale (mNSS) scores.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	AKT serine/threonine kinase 1	Rattus norvegicus	121-124
34448677-7	2021	Moreover, PPAR-gamma antagonist GW9662 or PI3K/AKT inhibitor LY294002 abrogated the anti-apoptosis and anti-inflammatory effects of stevioside on MCAO/R rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Rattus norvegicus	47-50
34715362-6	2021	Moreover, an inhibitor of AKT (LY294002) rescued the effect of PRMT1 knockdown on IL-1beta-induced ECM degradation and apoptosis, and AMI-1, a selective inhibitor of PRMT1, inhibited PRMT1 expression and reversed the pathological progress of TMJOA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Rattus norvegicus	26-29
34715362-6	2021	Moreover, an inhibitor of AKT (LY294002) rescued the effect of PRMT1 knockdown on IL-1beta-induced ECM degradation and apoptosis, and AMI-1, a selective inhibitor of PRMT1, inhibited PRMT1 expression and reversed the pathological progress of TMJOA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	protein arginine methyltransferase 1	Rattus norvegicus	63-68
34741867-7	2021	To dissect the signaling pathway leading to SGK1 upregulation, we pretreated THP-1-derived macrophages with specific inhibitors of Notch (DAPT), AKT (LY294002) or ERK (U0126).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	150-158	AKT serine/threonine kinase 1	Homo sapiens	145-148
34715362-6	2021	Moreover, an inhibitor of AKT (LY294002) rescued the effect of PRMT1 knockdown on IL-1beta-induced ECM degradation and apoptosis, and AMI-1, a selective inhibitor of PRMT1, inhibited PRMT1 expression and reversed the pathological progress of TMJOA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	interleukin 1 alpha	Rattus norvegicus	82-90
34741867-8	2021	Among these inhibitors, only LY294002 decreased the SGK1 mRNA levels in M(IL-4), indicating that the AKT pathway plays a key role in SGK1 transcription in M(IL-4).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	serum/glucocorticoid regulated kinase 1	Homo sapiens	52-56
34741867-8	2021	Among these inhibitors, only LY294002 decreased the SGK1 mRNA levels in M(IL-4), indicating that the AKT pathway plays a key role in SGK1 transcription in M(IL-4).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	101-104
34741867-8	2021	Among these inhibitors, only LY294002 decreased the SGK1 mRNA levels in M(IL-4), indicating that the AKT pathway plays a key role in SGK1 transcription in M(IL-4).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	serum/glucocorticoid regulated kinase 1	Homo sapiens	133-137
34506777-8	2021	We found that an alpha2-adrenoceptor (alpha2-AR) antagonist (yohimbine) completely aborted DEX-induced B1R and B2R regulation; an adenylyl cyclase (AC) agonist (forskolin) blocked B1R downregulation, while a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) blocked B2R upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	256-264	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	208-237
34666114-9	2021	Furthermore, regulation of the AKT/GSK3beta/CRMP2 signaling pathway by an LY294002 microinjection in the hippocampus resulted in cytoskeletal alterations and depressive-like behaviors in rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	AKT serine/threonine kinase 1	Rattus norvegicus	31-34
34666114-9	2021	Furthermore, regulation of the AKT/GSK3beta/CRMP2 signaling pathway by an LY294002 microinjection in the hippocampus resulted in cytoskeletal alterations and depressive-like behaviors in rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	glycogen synthase kinase 3 alpha	Rattus norvegicus	35-43
34666114-9	2021	Furthermore, regulation of the AKT/GSK3beta/CRMP2 signaling pathway by an LY294002 microinjection in the hippocampus resulted in cytoskeletal alterations and depressive-like behaviors in rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	74-82	dihydropyrimidinase-like 2	Rattus norvegicus	44-49
34830972-7	2021	Such a defect in PI3K/AKT signaling was responsible for reduced MCS growth and cell evasion, as demonstrated by the inhibition of the pathway in control MCS using LY294002 or Perifosine, which did not significantly affect Tau-depleted MCS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	163-171	AKT serine/threonine kinase 1	Homo sapiens	22-25
34799978-2	2021	First, western-blot and real-time quantitative PCR were used to detect the effect of simvastatin or LY294002 on the expression levels of AKT, miR-9 and KLF5, or determine the effect of miR-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	AKT serine/threonine kinase 1	Homo sapiens	137-140
34799978-2	2021	First, western-blot and real-time quantitative PCR were used to detect the effect of simvastatin or LY294002 on the expression levels of AKT, miR-9 and KLF5, or determine the effect of miR-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	Kruppel like factor 5	Homo sapiens	152-156
34799978-3	2021	Simvastatin, KLF5 and AKT significantly enhanced the proliferation of pulp stem cells, whilst this effect induced by simvastatin was suppressed by LY294002, AKT siRNA, KLF5 siRNA and miR-9, and simvastatin dose-dependently upregulated the expression of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	Kruppel like factor 5	Homo sapiens	13-17
34799978-3	2021	Simvastatin, KLF5 and AKT significantly enhanced the proliferation of pulp stem cells, whilst this effect induced by simvastatin was suppressed by LY294002, AKT siRNA, KLF5 siRNA and miR-9, and simvastatin dose-dependently upregulated the expression of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	AKT serine/threonine kinase 1	Homo sapiens	22-25
34799978-5	2021	LY294002 abrogated the upregulation of p-AKT expression levels induced by simvastatin, and LY294002 induced the miR-9 expression and simvastatin dose-dependently inhibited the expression of miR-9, by contrast, LY294002 reduced the KLF5 expression and simvastatin dose-dependently promoted the expression of KLF5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	41-44
34799978-5	2021	LY294002 abrogated the upregulation of p-AKT expression levels induced by simvastatin, and LY294002 induced the miR-9 expression and simvastatin dose-dependently inhibited the expression of miR-9, by contrast, LY294002 reduced the KLF5 expression and simvastatin dose-dependently promoted the expression of KLF5.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	210-218	Kruppel like factor 5	Homo sapiens	231-235
34552006-6	2021	We compared the effects of LY294002 that inhibit with equal potency all class I isoenzymes and downstream mTOR with the action of inhibitors with higher isoform-selectivity towards PI3Kalpha, PI3Kbeta or PI3Kgamma (namely A66, TGX-221 and AS-252424).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	mechanistic target of rapamycin kinase	Homo sapiens	106-110
34543169-9	2021	LY294002 further inhibited cell viability, increased apoptosis, and down-regulated p-Akt/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	85-88
34543169-9	2021	LY294002 further inhibited cell viability, increased apoptosis, and down-regulated p-Akt/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	89-92
34865170-10	2022	Moreover, administration of the PI3K/AKT inhibitor LY294002 abolished amelioration by SOMCL-668 of chronic PCP-induced schizophrenia-related behaviors by inhibition of BDNF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	thymoma viral proto-oncogene 1	Mus musculus	37-40
34865170-10	2022	Moreover, administration of the PI3K/AKT inhibitor LY294002 abolished amelioration by SOMCL-668 of chronic PCP-induced schizophrenia-related behaviors by inhibition of BDNF expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	brain derived neurotrophic factor	Mus musculus	168-172
34846946-6	2022	Mechanistically, PI3K/Akt pathway was mediated by SET8 and inhibition of PI3K/Akt signaling pathway by giving LY294002 or transfecting Akt phosphorylation inactivated mutation plasmid increased apoptosis and calcification.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Homo sapiens	22-25
34846946-6	2022	Mechanistically, PI3K/Akt pathway was mediated by SET8 and inhibition of PI3K/Akt signaling pathway by giving LY294002 or transfecting Akt phosphorylation inactivated mutation plasmid increased apoptosis and calcification.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Homo sapiens	78-81
34789212-7	2021	In contrast, genistein and blocking phosphoinositide 3-kinases by wortmannin and LY294002 increased the milk-induced IL11 expression in gingival fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	interleukin 11	Homo sapiens	117-121
34506777-8	2021	We found that an alpha2-adrenoceptor (alpha2-AR) antagonist (yohimbine) completely aborted DEX-induced B1R and B2R regulation; an adenylyl cyclase (AC) agonist (forskolin) blocked B1R downregulation, while a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) blocked B2R upregulation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	256-264	bradykinin receptor B2	Rattus norvegicus	274-277
34605863-8	2021	Mechanistic studies identified that lung cancer cell-derived exosomes activated the PI3K/Akt pathway, and transfection of si-FOXD3-AS1 or treatment with the PI3K inhibitor LY294002 reversed the activation of the PI3K/Akt axis induced by exosomes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	AKT serine/threonine kinase 1	Homo sapiens	89-92
34605863-8	2021	Mechanistic studies identified that lung cancer cell-derived exosomes activated the PI3K/Akt pathway, and transfection of si-FOXD3-AS1 or treatment with the PI3K inhibitor LY294002 reversed the activation of the PI3K/Akt axis induced by exosomes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	AKT serine/threonine kinase 1	Homo sapiens	217-220
34771123-8	2021	Furthermore, HMH inhibited the PI3K/AKT/mTOR pathway by significantly reducing p-AKT expression in combination with LY294002, an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	mechanistic target of rapamycin kinase	Homo sapiens	40-44
34820336-0	2021	LY294002 Is a Promising Inhibitor to Overcome Sorafenib Resistance in FLT3-ITD Mutant AML Cells by Interfering With PI3K/Akt Signaling Pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	fms related receptor tyrosine kinase 3	Homo sapiens	70-74
34820336-0	2021	LY294002 Is a Promising Inhibitor to Overcome Sorafenib Resistance in FLT3-ITD Mutant AML Cells by Interfering With PI3K/Akt Signaling Pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	121-124
34820336-8	2021	PI3K inhibitor, LY294002, can block PI3K/AKT signaling, further inhibit glycolysis to disturb ATP production, and finally induce cell apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	AKT serine/threonine kinase 1	Homo sapiens	41-44
34771123-8	2021	Furthermore, HMH inhibited the PI3K/AKT/mTOR pathway by significantly reducing p-AKT expression in combination with LY294002, an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	AKT serine/threonine kinase 1	Homo sapiens	129-132
34537206-9	2021	Importantly, treatment of LY294002 (an inhibitor of the PI3K/Akt pathway) attenuated miR-17-5p-mediated osteoclastogenesis effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	thymoma viral proto-oncogene 1	Mus musculus	61-64
34725674-6	2022	The delay in cyst breakdown was mitigated when ovaries were dually dosed with LY294002 and KITL, suggesting that while KIT may signal through PI3K to promote cyst breakdown, other signaling networks downstream of the receptor could compensate.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	119-122
34736257-9	2022	Furthermore, PM2.5induced activation of PI3K, AKT, and ERK, and pretreatment of HNECs with AG1478 or LY294002 attenuated PM2.5-induced MUC5AC mRNA and protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	101-109	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	135-141
34765012-9	2021	Treatment with PI3K inhibitors, LY294002 and wortmannin, or mTOR inhibitors, rapamycin and Torin 1, could not only recover QYLGT-inhibited cell viability of NPC cells but also inhibit Atg3 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	autophagy related 3	Homo sapiens	184-188
34465632-8	2021	Besides, inhibitors of ALX, cAMP, and PI3K (BOC-2, KH-7, and LY294002) notably inhibited the effects of RCTR1 on AFC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	solute carrier family 31 member 1	Rattus norvegicus	104-109
34584545-13	2021	Furthermore, PI3K inhibitor (LY294002) and CXCR4 inhibitor (AMD3100) effectively inhibited the proliferation, migration and resistance to apoptosis of CXCR4-mediated BM-EPCs under hypoxic conditions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	C-X-C motif chemokine receptor 4	Rattus norvegicus	151-156
34721013-8	2021	The protective effect of Hederagenin was reversed by a specific phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and AKT (also known as protein kinase B) inhibitor MK2206, suggesting that the effect of Hederagenin is mediated by the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	64-93
34547381-7	2021	In addition, the DHT-induced COX-2 expression and PGF2alpha release were subjected to the regulation of both EGFR/PI3K/Akt/NFkB signaling as the inhibitors of EGFR (AG1478) and PI3K/Akt (LY294002) and NFkB (QNZ) attenuated the DHT mediated effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	prostaglandin-endoperoxide synthase 2	Bos taurus	29-34
34547381-7	2021	In addition, the DHT-induced COX-2 expression and PGF2alpha release were subjected to the regulation of both EGFR/PI3K/Akt/NFkB signaling as the inhibitors of EGFR (AG1478) and PI3K/Akt (LY294002) and NFkB (QNZ) attenuated the DHT mediated effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	epidermal growth factor receptor	Bos taurus	109-113
34547381-7	2021	In addition, the DHT-induced COX-2 expression and PGF2alpha release were subjected to the regulation of both EGFR/PI3K/Akt/NFkB signaling as the inhibitors of EGFR (AG1478) and PI3K/Akt (LY294002) and NFkB (QNZ) attenuated the DHT mediated effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	187-195	AKT serine/threonine kinase 1	Bos taurus	182-185
34755491-7	2021	2-F-L-a also increased proliferation and PDGFRalpha expression in NIH/3T3 cells cultured in high glucose, while LY294002, a PI3K antagonist, decreased cell proliferation and PDGFRalpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	112-120	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	174-184
34755491-9	2021	2-F-L-a also reduced PI3K, Akt, and p-Akt protein expression in NIH/3T3 cells, while the PI3K antagonist LY294002 increased this expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	thymoma viral proto-oncogene 1	Mus musculus	27-30
34821092-7	2021	Results: Compared with the control group, the percentage of PD-L1 positive cells and PD-L1 red fluorescence intensity of DCs were all increased(P<0.01), while DCs- mediated T cell proliferation and gamma-interferon spot-forming cell number were decreased (P<0.01).PI3K inhibitor LY294002, NF-kappaB inhibitor PDTC and PD-L1 blocking antibody could significantly reverse the inhibition of DCs mediated T lymphocytes immunosuppression above (P<0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	279-287	CD274 antigen	Mus musculus	60-65
34821092-7	2021	Results: Compared with the control group, the percentage of PD-L1 positive cells and PD-L1 red fluorescence intensity of DCs were all increased(P<0.01), while DCs- mediated T cell proliferation and gamma-interferon spot-forming cell number were decreased (P<0.01).PI3K inhibitor LY294002, NF-kappaB inhibitor PDTC and PD-L1 blocking antibody could significantly reverse the inhibition of DCs mediated T lymphocytes immunosuppression above (P<0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	279-287	CD274 antigen	Mus musculus	85-90
34708340-11	2022	Furthermore, CQ and LY294002 neutralized the effects of overexpressed ACE2 on neuronal apoptosis, cerebral edema, and neurological deficits in SAH mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	70-74
34666758-9	2021	RESULTS: SC79 induced a ~ twofold induction of p-eNOS and Nrf-2 protein levels blocked by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	nitric oxide synthase 3	Homo sapiens	49-53
34666758-9	2021	RESULTS: SC79 induced a ~ twofold induction of p-eNOS and Nrf-2 protein levels blocked by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	NFE2 like bZIP transcription factor 2	Homo sapiens	58-63
34364877-7	2021	Mechanistically, Sal B treatment up-regulated the phosphorylated level of Akt and GSK3beta in enterocytes in vitro and in vivo, and PI3K inhibitor LY294002 treatment abrogated the protective effects of Sal B.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
34364877-7	2021	Mechanistically, Sal B treatment up-regulated the phosphorylated level of Akt and GSK3beta in enterocytes in vitro and in vivo, and PI3K inhibitor LY294002 treatment abrogated the protective effects of Sal B.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	147-155	glycogen synthase kinase 3 alpha	Rattus norvegicus	82-90
34681783-10	2021	Treatment of neurospheres with PIM1 inhibitors (TCS PIM1-1, Quercetagetin, and LY294002) diminished the cell viability associated with reduced DNA synthesis rate, increased caspase 3 activity, decreased PCNA protein expression, and reduced neurosphere formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	proviral integration site 1	Mus musculus	31-35
34681783-10	2021	Treatment of neurospheres with PIM1 inhibitors (TCS PIM1-1, Quercetagetin, and LY294002) diminished the cell viability associated with reduced DNA synthesis rate, increased caspase 3 activity, decreased PCNA protein expression, and reduced neurosphere formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	caspase 3	Mus musculus	173-182
34681783-10	2021	Treatment of neurospheres with PIM1 inhibitors (TCS PIM1-1, Quercetagetin, and LY294002) diminished the cell viability associated with reduced DNA synthesis rate, increased caspase 3 activity, decreased PCNA protein expression, and reduced neurosphere formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	79-87	proliferating cell nuclear antigen	Mus musculus	203-207
34691190-7	2021	We successfully isolated and purified exosomes from ADSC supernatant and found that ADSC-exo treatment significantly promoted PC12 cell proliferation and migration, inhibited their apoptosis, and activated the PI3K/AKT pathway, while PI3K/AKT signaling repression using LY294002 exhibited the opposite effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	270-278	AKT serine/threonine kinase 1	Rattus norvegicus	239-242
34146182-11	2021	The PI3K/Akt signaling suppression using LY294002 reversed the inhibitive effect of higenamine on IL-1beta-caused apoptosis, and this effect was weakened by ROS inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	AKT serine/threonine kinase 1	Homo sapiens	9-12
34146182-11	2021	The PI3K/Akt signaling suppression using LY294002 reversed the inhibitive effect of higenamine on IL-1beta-caused apoptosis, and this effect was weakened by ROS inhibition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	interleukin 1 alpha	Homo sapiens	98-106
34597905-10	2021	LiCl and LY294002 were adopted to block and increase the activity of glycogen synthase kinase 3beta (GSK3beta), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	glycogen synthase kinase 3 beta	Rattus norvegicus	69-99
34597905-10	2021	LiCl and LY294002 were adopted to block and increase the activity of glycogen synthase kinase 3beta (GSK3beta), respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	glycogen synthase kinase 3 alpha	Rattus norvegicus	101-109
34597905-16	2021	LY294002 abrogated the inhibitory effects of PRRDG on thrombus weight, TF protein expression, TNF-alpha and IL-1beta serum levels, inflammatory cells influxes, and p-p65 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Mus musculus	94-103
34597905-16	2021	LY294002 abrogated the inhibitory effects of PRRDG on thrombus weight, TF protein expression, TNF-alpha and IL-1beta serum levels, inflammatory cells influxes, and p-p65 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 alpha	Mus musculus	108-116
34597905-16	2021	LY294002 abrogated the inhibitory effects of PRRDG on thrombus weight, TF protein expression, TNF-alpha and IL-1beta serum levels, inflammatory cells influxes, and p-p65 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	synaptotagmin 1	Rattus norvegicus	166-169
34822557-6	2021	Moreover, we observed that inhibition of phosphoinositide 3 kinase (PI3K)/AKT using LY294002 (50 microM) could reverse the alterations in FOXA2 and MUC5AC expression -by IL-13 and BV.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	41-66
34822557-6	2021	Moreover, we observed that inhibition of phosphoinositide 3 kinase (PI3K)/AKT using LY294002 (50 microM) could reverse the alterations in FOXA2 and MUC5AC expression -by IL-13 and BV.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Homo sapiens	74-77
34822557-6	2021	Moreover, we observed that inhibition of phosphoinositide 3 kinase (PI3K)/AKT using LY294002 (50 microM) could reverse the alterations in FOXA2 and MUC5AC expression -by IL-13 and BV.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	forkhead box A2	Homo sapiens	138-143
34822557-6	2021	Moreover, we observed that inhibition of phosphoinositide 3 kinase (PI3K)/AKT using LY294002 (50 microM) could reverse the alterations in FOXA2 and MUC5AC expression -by IL-13 and BV.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	148-154
34822557-6	2021	Moreover, we observed that inhibition of phosphoinositide 3 kinase (PI3K)/AKT using LY294002 (50 microM) could reverse the alterations in FOXA2 and MUC5AC expression -by IL-13 and BV.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	interleukin 13	Homo sapiens	170-175
34689241-8	2021	RESULTS: After pretreatment with LY294002, Triciribine and Rapamycin, the p-Akt/Akt ratio of pathway protein in Triciribine and Rapamycin groups decreased (P < 0.05), while the autophagy protein LC3-II/LC3-I in the Rapamycin group was upregulated obviously (P < 0.001).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	thymoma viral proto-oncogene 1	Mus musculus	76-79
34689241-8	2021	RESULTS: After pretreatment with LY294002, Triciribine and Rapamycin, the p-Akt/Akt ratio of pathway protein in Triciribine and Rapamycin groups decreased (P < 0.05), while the autophagy protein LC3-II/LC3-I in the Rapamycin group was upregulated obviously (P < 0.001).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	thymoma viral proto-oncogene 1	Mus musculus	80-83
34663382-9	2021	FGF-2-mediated anti-apoptosis was impaired by inactivating the PI3K/AKT pathway with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	fibroblast growth factor 2	Mus musculus	0-5
34663382-9	2021	FGF-2-mediated anti-apoptosis was impaired by inactivating the PI3K/AKT pathway with LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	thymoma viral proto-oncogene 1	Mus musculus	68-71
34721013-8	2021	The protective effect of Hederagenin was reversed by a specific phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and AKT (also known as protein kinase B) inhibitor MK2206, suggesting that the effect of Hederagenin is mediated by the PI3K/AKT pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	111-119	AKT serine/threonine kinase 1	Rattus norvegicus	245-248
34635126-9	2021	We also cultured motor neuron-like NSC-34 cells transfected with a plasmid to overexpress mutant SOD1G93A and starved them in serum-free medium for 24 h with and without bpV(pic) and downstream inhibitor of Akt signaling, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	222-230	thymoma viral proto-oncogene 1	Mus musculus	207-210
34620219-15	2021	LY294002 partially reversed the promotion effects of Astragaloside on ALP, OCN, and OSX of MC3T3-E1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	alopecia, recessive	Mus musculus	70-73
34620219-15	2021	LY294002 partially reversed the promotion effects of Astragaloside on ALP, OCN, and OSX of MC3T3-E1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Sp7 transcription factor 7	Mus musculus	84-87
34358859-8	2021	LY294002, an inhibitor of PI3K/Akt signaling, was used to elucidate the relationship between ME and PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	31-34
34333060-11	2021	Moreover, LY294002, an AKT inhibitor, suppressed the proliferative activity of chondrocytes under negative pressure, while SC79, an activator of AKT phosphorylation, enhanced the proliferation of chondrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
34406990-11	2021	Inhibition of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling with LY29400 increased LMP7 expression and abolished the protective effects of ONX-0914 in HIBD rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-94	AKT serine/threonine kinase 1	Rattus norvegicus	67-70
34406990-11	2021	Inhibition of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling with LY29400 increased LMP7 expression and abolished the protective effects of ONX-0914 in HIBD rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-94	proteasome 20S subunit beta 8	Rattus norvegicus	105-109
34082015-17	2021	Furthermore, the effects of SZL on myelin proteins, p-Akt, and p-mTOR were clearly inhibited by LY294002 and/or rapamycin, antagonists of PI3K and m-TOR, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
34082015-17	2021	Furthermore, the effects of SZL on myelin proteins, p-Akt, and p-mTOR were clearly inhibited by LY294002 and/or rapamycin, antagonists of PI3K and m-TOR, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	mechanistic target of rapamycin kinase	Rattus norvegicus	65-69
34082015-17	2021	Furthermore, the effects of SZL on myelin proteins, p-Akt, and p-mTOR were clearly inhibited by LY294002 and/or rapamycin, antagonists of PI3K and m-TOR, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	tortured	Mus musculus	149-152
34437815-8	2021	siCEMIP or PI3K/AKT signaling inhibitor (Akti-1/2 and LY294002) partly reversed the effects of miR-4677-3p on the cellular growth and metastasis of gastric cancer.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	16-19
34358859-8	2021	LY294002, an inhibitor of PI3K/Akt signaling, was used to elucidate the relationship between ME and PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	105-108
34399087-3	2021	Treatment of JEG-3 cells with DEX (1microM), GRalpha siRNA, LY294002 (50microM), XO/HX (7.2microM/36nM) or rapamycin (80nM) inhibited cell proliferation, induced apoptosis, significantly decreased MMP and hCG and hPL content and increased ROS levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	galectin 1	Homo sapiens	213-216
34392578-13	2021	Inhibition of PI3K/PKB/GSK-3beta pathway by LY294002 blocked the effects of sciadopitysin on HG-induced injury, oxidative stress, and apoptosis in AC16 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	protein tyrosine kinase 2 beta	Homo sapiens	19-22
34392578-13	2021	Inhibition of PI3K/PKB/GSK-3beta pathway by LY294002 blocked the effects of sciadopitysin on HG-induced injury, oxidative stress, and apoptosis in AC16 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	glycogen synthase kinase 3 alpha	Homo sapiens	23-32
34332284-8	2021	DMBQ increased the phosphorylation of protein kinase B (AKT) and p70 ribosomal protein S6 kinase (S6K), whereas the phosphorylation of these proteins was abolished by the phosphoinositide 3-kinase inhibitor LY294002 in C2C12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	thymoma viral proto-oncogene 1	Mus musculus	56-59
34332284-8	2021	DMBQ increased the phosphorylation of protein kinase B (AKT) and p70 ribosomal protein S6 kinase (S6K), whereas the phosphorylation of these proteins was abolished by the phosphoinositide 3-kinase inhibitor LY294002 in C2C12 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	98-101
34399087-5	2021	Treatment of JEG-3 cells with GRalpha siRNA, LY294002, XO/HX or rapamycin inhibited phosphorylation of phosphatidylinositol 3-kinase (PI3K), Akt, glycogen synthase kinase 3 and mammalian target of rapamycin (mTOR) and induced the phosphorylation of AMP-activated protein kinase (AMPK) and tuberous sclerosis complex 2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	103-132
34399087-5	2021	Treatment of JEG-3 cells with GRalpha siRNA, LY294002, XO/HX or rapamycin inhibited phosphorylation of phosphatidylinositol 3-kinase (PI3K), Akt, glycogen synthase kinase 3 and mammalian target of rapamycin (mTOR) and induced the phosphorylation of AMP-activated protein kinase (AMPK) and tuberous sclerosis complex 2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	AKT serine/threonine kinase 1	Homo sapiens	141-144
34399087-5	2021	Treatment of JEG-3 cells with GRalpha siRNA, LY294002, XO/HX or rapamycin inhibited phosphorylation of phosphatidylinositol 3-kinase (PI3K), Akt, glycogen synthase kinase 3 and mammalian target of rapamycin (mTOR) and induced the phosphorylation of AMP-activated protein kinase (AMPK) and tuberous sclerosis complex 2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	mechanistic target of rapamycin kinase	Homo sapiens	177-206
34399087-5	2021	Treatment of JEG-3 cells with GRalpha siRNA, LY294002, XO/HX or rapamycin inhibited phosphorylation of phosphatidylinositol 3-kinase (PI3K), Akt, glycogen synthase kinase 3 and mammalian target of rapamycin (mTOR) and induced the phosphorylation of AMP-activated protein kinase (AMPK) and tuberous sclerosis complex 2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	mechanistic target of rapamycin kinase	Homo sapiens	208-212
34399087-5	2021	Treatment of JEG-3 cells with GRalpha siRNA, LY294002, XO/HX or rapamycin inhibited phosphorylation of phosphatidylinositol 3-kinase (PI3K), Akt, glycogen synthase kinase 3 and mammalian target of rapamycin (mTOR) and induced the phosphorylation of AMP-activated protein kinase (AMPK) and tuberous sclerosis complex 2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	249-277
34399087-5	2021	Treatment of JEG-3 cells with GRalpha siRNA, LY294002, XO/HX or rapamycin inhibited phosphorylation of phosphatidylinositol 3-kinase (PI3K), Akt, glycogen synthase kinase 3 and mammalian target of rapamycin (mTOR) and induced the phosphorylation of AMP-activated protein kinase (AMPK) and tuberous sclerosis complex 2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	279-283
34698101-4	2021	This increase in GU was partially, but significantly canceled by TXF treatment in combination with either LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), which phosphorylates protein kinase B (Akt) or Compound C, an inhibitor of 5"-adenosine monophosphate-activated protein kinase (AMPK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	132-161
34339756-11	2021	Gene and protein detection showed that DG-8d or DG-8d combined with LY294002 could down-regulate signaling molecules of Bcl-2, PI3k, p-Akt, p-FoxO3a and up-regulate signaling molecules of Bax snd Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	BCL2 apoptosis regulator	Homo sapiens	120-125
34339756-11	2021	Gene and protein detection showed that DG-8d or DG-8d combined with LY294002 could down-regulate signaling molecules of Bcl-2, PI3k, p-Akt, p-FoxO3a and up-regulate signaling molecules of Bax snd Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	AKT serine/threonine kinase 1	Homo sapiens	135-138
34339756-11	2021	Gene and protein detection showed that DG-8d or DG-8d combined with LY294002 could down-regulate signaling molecules of Bcl-2, PI3k, p-Akt, p-FoxO3a and up-regulate signaling molecules of Bax snd Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	forkhead box O3	Homo sapiens	142-148
34339756-11	2021	Gene and protein detection showed that DG-8d or DG-8d combined with LY294002 could down-regulate signaling molecules of Bcl-2, PI3k, p-Akt, p-FoxO3a and up-regulate signaling molecules of Bax snd Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	BCL2 associated X, apoptosis regulator	Homo sapiens	188-191
34339756-11	2021	Gene and protein detection showed that DG-8d or DG-8d combined with LY294002 could down-regulate signaling molecules of Bcl-2, PI3k, p-Akt, p-FoxO3a and up-regulate signaling molecules of Bax snd Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	BCL2 like 11	Homo sapiens	196-199
34627416-8	2021	Over expressed PKM2, HL-60 cells were treated with PI3K inhibitor LY294002 or galactose, the changes in cell proliferation ability, cell cycle and apoptosis, as well as changes in glucose consumption and lactic acid production were detected.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	pyruvate kinase M1/2	Homo sapiens	15-19
34627416-13	2021	Overexpressed PKM2, HL-60 cells were treated with PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	pyruvate kinase M1/2	Homo sapiens	14-18
34597809-7	2022	Hirsutine exhibited the effects on enhancing glucose consumption and uptake in IR cell models via activating phosphatidylinositol 3-kinase (PI3K)/Akt pathway, which was blocked by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	109-138
34597809-7	2022	Hirsutine exhibited the effects on enhancing glucose consumption and uptake in IR cell models via activating phosphatidylinositol 3-kinase (PI3K)/Akt pathway, which was blocked by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	thymoma viral proto-oncogene 1	Mus musculus	146-149
34698101-4	2021	This increase in GU was partially, but significantly canceled by TXF treatment in combination with either LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), which phosphorylates protein kinase B (Akt) or Compound C, an inhibitor of 5"-adenosine monophosphate-activated protein kinase (AMPK).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	thymoma viral proto-oncogene 1	Mus musculus	209-212
34553399-9	2022	PI3K/Akt inactivation by LY294002 resisted the effects of fraxetin on isoflurane-induced autophagy and autophagy-modulated neurotoxicity in HT22 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	thymoma viral proto-oncogene 1	Mus musculus	5-8
34530574-20	2021	Compared with NC group, overexpression of CacyBP inhibited E-cadherin expression while promoted the expressions of N-cadherin, Snail1, Vimentin and p-Akt, which could be restored by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	calcyclin binding protein	Homo sapiens	42-48
34530574-20	2021	Compared with NC group, overexpression of CacyBP inhibited E-cadherin expression while promoted the expressions of N-cadherin, Snail1, Vimentin and p-Akt, which could be restored by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	cadherin 1	Homo sapiens	59-69
34530574-20	2021	Compared with NC group, overexpression of CacyBP inhibited E-cadherin expression while promoted the expressions of N-cadherin, Snail1, Vimentin and p-Akt, which could be restored by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	cadherin 2	Homo sapiens	115-125
34530574-20	2021	Compared with NC group, overexpression of CacyBP inhibited E-cadherin expression while promoted the expressions of N-cadherin, Snail1, Vimentin and p-Akt, which could be restored by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	snail family transcriptional repressor 1	Homo sapiens	127-133
34530574-20	2021	Compared with NC group, overexpression of CacyBP inhibited E-cadherin expression while promoted the expressions of N-cadherin, Snail1, Vimentin and p-Akt, which could be restored by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	vimentin	Homo sapiens	135-143
34530574-20	2021	Compared with NC group, overexpression of CacyBP inhibited E-cadherin expression while promoted the expressions of N-cadherin, Snail1, Vimentin and p-Akt, which could be restored by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	182-190	AKT serine/threonine kinase 1	Homo sapiens	150-153
34553450-7	2021	Finally, the potential downstream mechanisms were investigated, and we expectedly found that METTL3 activated the PI3K/Akt pathway in H/R-treated cardiomyocytes through modulating miR-25-3p and miR-873-5p, and the PI3K/Akt pathway inhibitor (LY294002) abrogated the protective effects of METTL3 overexpression in cardiomyocytes with H/R treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	methyltransferase like 3	Mus musculus	93-99
34553450-7	2021	Finally, the potential downstream mechanisms were investigated, and we expectedly found that METTL3 activated the PI3K/Akt pathway in H/R-treated cardiomyocytes through modulating miR-25-3p and miR-873-5p, and the PI3K/Akt pathway inhibitor (LY294002) abrogated the protective effects of METTL3 overexpression in cardiomyocytes with H/R treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	thymoma viral proto-oncogene 1	Mus musculus	119-122
34553450-7	2021	Finally, the potential downstream mechanisms were investigated, and we expectedly found that METTL3 activated the PI3K/Akt pathway in H/R-treated cardiomyocytes through modulating miR-25-3p and miR-873-5p, and the PI3K/Akt pathway inhibitor (LY294002) abrogated the protective effects of METTL3 overexpression in cardiomyocytes with H/R treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	thymoma viral proto-oncogene 1	Mus musculus	219-222
34553450-7	2021	Finally, the potential downstream mechanisms were investigated, and we expectedly found that METTL3 activated the PI3K/Akt pathway in H/R-treated cardiomyocytes through modulating miR-25-3p and miR-873-5p, and the PI3K/Akt pathway inhibitor (LY294002) abrogated the protective effects of METTL3 overexpression in cardiomyocytes with H/R treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	242-250	methyltransferase like 3	Mus musculus	288-294
34469122-9	2021	LY294002 also restored the expressions of pCREB/BDNF/PSD95/Synapsin1 signaling in the hippocampus impaired by LPS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	brain derived neurotrophic factor	Mus musculus	48-52
34603025-11	2021	Additionally, administration of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway inhibitors MK-2206 and LY294002 abolished the beneficial effects of gastrodin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	36-65
34603025-11	2021	Additionally, administration of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway inhibitors MK-2206 and LY294002 abolished the beneficial effects of gastrodin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	AKT serine/threonine kinase 1	Homo sapiens	73-76
34469122-9	2021	LY294002 also restored the expressions of pCREB/BDNF/PSD95/Synapsin1 signaling in the hippocampus impaired by LPS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	discs large MAGUK scaffold protein 4	Mus musculus	53-58
34469122-9	2021	LY294002 also restored the expressions of pCREB/BDNF/PSD95/Synapsin1 signaling in the hippocampus impaired by LPS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	synapsin I	Mus musculus	59-68
34546326-9	2021	OPN promoted proliferation and migration rate of OFs and induced vascular endothelial growth factor (VEGF) and collagen I mRNA expression, and the effects were inhibited by 1A12 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	secreted phosphoprotein 1	Homo sapiens	0-3
34482683-5	2021	Moreover, there is an interaction between the up-regulation of Nrf2 and the down-regulation of NFkappaB induced by the peptide, which was related to the generation of reactive oxygen species (ROS) and could be abolished by the Akt inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	241-249	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
34546326-9	2021	OPN promoted proliferation and migration rate of OFs and induced vascular endothelial growth factor (VEGF) and collagen I mRNA expression, and the effects were inhibited by 1A12 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	vascular endothelial growth factor A	Homo sapiens	65-99
34546326-9	2021	OPN promoted proliferation and migration rate of OFs and induced vascular endothelial growth factor (VEGF) and collagen I mRNA expression, and the effects were inhibited by 1A12 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	181-189	vascular endothelial growth factor A	Homo sapiens	101-105
34733929-6	2021	The phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002 was used to block the Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	4-33
34733929-6	2021	The phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002 was used to block the Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
34733929-6	2021	The phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002 was used to block the Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	AKT serine/threonine kinase 1	Rattus norvegicus	86-89
34475057-5	2021	RESULTS: To identify the pathway associated with HGF-induced PHLDA2 up-regulation, the cells were treated with PI3-kinase inhibitor (LY294002), MEK inhibitor (PD098059), or p38 inhibitor (SB203580) and then analyzed by western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	hepatocyte growth factor	Homo sapiens	49-52
34697781-4	2021	LY294002 (a PI3K/Akt inhibitor) and IGF-1 (a PI3K/Akt activator) were employed to investigate the expression of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	17-20
34475057-5	2021	RESULTS: To identify the pathway associated with HGF-induced PHLDA2 up-regulation, the cells were treated with PI3-kinase inhibitor (LY294002), MEK inhibitor (PD098059), or p38 inhibitor (SB203580) and then analyzed by western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	pleckstrin homology like domain family A member 2	Homo sapiens	61-67
34475057-6	2021	HGF-mediated changes in PHLDA2 protein levels were only decreased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	hepatocyte growth factor	Homo sapiens	0-3
34475057-6	2021	HGF-mediated changes in PHLDA2 protein levels were only decreased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	pleckstrin homology like domain family A member 2	Homo sapiens	24-30
34345290-10	2021	LY294002, a PI3K inhibitor, reversed the protective effects of NBP and suppressed the expression of HSP70.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	100-105
34540654-11	2021	This effect was attenuated by the Akt inhibitor ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	AKT serine/threonine kinase 1	Homo sapiens	34-37
34521048-2	2021	METHODS: GDM mice models were established and treated with Apelin-13 and/or PI3K/AKT inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	thymoma viral proto-oncogene 1	Mus musculus	81-84
34697781-4	2021	LY294002 (a PI3K/Akt inhibitor) and IGF-1 (a PI3K/Akt activator) were employed to investigate the expression of PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	117-120
34697781-11	2021	Western blotting results showed that JB and LY294002 treatment significantly inhibited the levels of Bcl-2, p-PI3K, and p-Akt while the levels of Bax, cleaved caspase-3, and PTEN protein significantly increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	BCL2 apoptosis regulator	Homo sapiens	101-106
34697781-11	2021	Western blotting results showed that JB and LY294002 treatment significantly inhibited the levels of Bcl-2, p-PI3K, and p-Akt while the levels of Bax, cleaved caspase-3, and PTEN protein significantly increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	AKT serine/threonine kinase 1	Homo sapiens	122-125
34697781-11	2021	Western blotting results showed that JB and LY294002 treatment significantly inhibited the levels of Bcl-2, p-PI3K, and p-Akt while the levels of Bax, cleaved caspase-3, and PTEN protein significantly increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	BCL2 associated X, apoptosis regulator	Homo sapiens	146-149
34697781-11	2021	Western blotting results showed that JB and LY294002 treatment significantly inhibited the levels of Bcl-2, p-PI3K, and p-Akt while the levels of Bax, cleaved caspase-3, and PTEN protein significantly increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	caspase 3	Homo sapiens	159-168
34697781-11	2021	Western blotting results showed that JB and LY294002 treatment significantly inhibited the levels of Bcl-2, p-PI3K, and p-Akt while the levels of Bax, cleaved caspase-3, and PTEN protein significantly increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	phosphatase and tensin homolog	Homo sapiens	174-178
34437900-9	2021	LY294002, a specific inhibitor of the PI3K pathway, reversed the protective effects of ghrelin on the endothelial cell barrier.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	ghrelin	Mus musculus	87-94
34168289-6	2021	In addition, the effects of a TGF-beta type I receptor inhibitor (A8301) and PI3K-Akt inhibitor (LY294002) on EMT were evaluated.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Homo sapiens	82-85
34273708-8	2021	For mechanism verification, LY294002, the inhibitor of PI3K/Akt pathway was introduced the expressions of bcl-2 and phosphorylated Akt were down-regulated, the expression of bax was up-regulated, indicating that XQ-1H could alleviate the cell apoptosis through activating the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
34273708-8	2021	For mechanism verification, LY294002, the inhibitor of PI3K/Akt pathway was introduced the expressions of bcl-2 and phosphorylated Akt were down-regulated, the expression of bax was up-regulated, indicating that XQ-1H could alleviate the cell apoptosis through activating the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	BCL2, apoptosis regulator	Rattus norvegicus	106-111
34168289-12	2021	LY294002 inhibited Akt phosphorylation induced by TGF-beta1 but failed to prevent EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	19-22
34168289-12	2021	LY294002 inhibited Akt phosphorylation induced by TGF-beta1 but failed to prevent EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	transforming growth factor beta 1	Homo sapiens	50-59
34446024-14	2021	Additionally, the effects of TIPE2 overexpression and TIPE2 knockdown were altered by IGF-1 and LY294002 treatments, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	TNF alpha induced protein 8 like 2	Homo sapiens	29-34
34273708-8	2021	For mechanism verification, LY294002, the inhibitor of PI3K/Akt pathway was introduced the expressions of bcl-2 and phosphorylated Akt were down-regulated, the expression of bax was up-regulated, indicating that XQ-1H could alleviate the cell apoptosis through activating the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	131-134
34273708-8	2021	For mechanism verification, LY294002, the inhibitor of PI3K/Akt pathway was introduced the expressions of bcl-2 and phosphorylated Akt were down-regulated, the expression of bax was up-regulated, indicating that XQ-1H could alleviate the cell apoptosis through activating the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	BCL2 associated X, apoptosis regulator	Rattus norvegicus	174-177
34273708-8	2021	For mechanism verification, LY294002, the inhibitor of PI3K/Akt pathway was introduced the expressions of bcl-2 and phosphorylated Akt were down-regulated, the expression of bax was up-regulated, indicating that XQ-1H could alleviate the cell apoptosis through activating the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	281-284
34446024-14	2021	Additionally, the effects of TIPE2 overexpression and TIPE2 knockdown were altered by IGF-1 and LY294002 treatments, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	TNF alpha induced protein 8 like 2	Homo sapiens	54-59
34497513-7	2021	In addition, eHSP90alpha induced ER stress in fibroblasts via the phosphoinositide-4,5-bisphosphate 3-kinase (PI3K)-protein kinase B (AKT) signaling pathway, which could be blocked by the PI3K/AKT inhibitor LY294002, and blockade of eHSP90alpha by 1G6-D7 markedly inhibited ER stress in the model, indicating preventive and therapeutic applications.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	66-108
34497513-7	2021	In addition, eHSP90alpha induced ER stress in fibroblasts via the phosphoinositide-4,5-bisphosphate 3-kinase (PI3K)-protein kinase B (AKT) signaling pathway, which could be blocked by the PI3K/AKT inhibitor LY294002, and blockade of eHSP90alpha by 1G6-D7 markedly inhibited ER stress in the model, indicating preventive and therapeutic applications.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	protein tyrosine kinase 2 beta	Homo sapiens	116-132
34497513-7	2021	In addition, eHSP90alpha induced ER stress in fibroblasts via the phosphoinositide-4,5-bisphosphate 3-kinase (PI3K)-protein kinase B (AKT) signaling pathway, which could be blocked by the PI3K/AKT inhibitor LY294002, and blockade of eHSP90alpha by 1G6-D7 markedly inhibited ER stress in the model, indicating preventive and therapeutic applications.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	AKT serine/threonine kinase 1	Homo sapiens	134-137
34497513-7	2021	In addition, eHSP90alpha induced ER stress in fibroblasts via the phosphoinositide-4,5-bisphosphate 3-kinase (PI3K)-protein kinase B (AKT) signaling pathway, which could be blocked by the PI3K/AKT inhibitor LY294002, and blockade of eHSP90alpha by 1G6-D7 markedly inhibited ER stress in the model, indicating preventive and therapeutic applications.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	AKT serine/threonine kinase 1	Homo sapiens	193-196
34419144-17	2021	LY294002, a PI3K inhibitor, attenuated the phosphorylation of PI3K, AKT, and NF-kappaB p65, and the nuclear translocation of NF-kappaB p65.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	68-71
34419144-17	2021	LY294002, a PI3K inhibitor, attenuated the phosphorylation of PI3K, AKT, and NF-kappaB p65, and the nuclear translocation of NF-kappaB p65.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	nuclear factor kappa B subunit 1	Homo sapiens	77-86
34418885-11	2022	PRO brought about the upregulation of proteins in PI3K/AKT signaling pathway, and LY294002 intervention further accentuated the impacts of APOM-knockdown on LPS-challenged HPMECs injury.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	apolipoprotein M	Homo sapiens	139-143
34419144-17	2021	LY294002, a PI3K inhibitor, attenuated the phosphorylation of PI3K, AKT, and NF-kappaB p65, and the nuclear translocation of NF-kappaB p65.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	87-90
34419144-17	2021	LY294002, a PI3K inhibitor, attenuated the phosphorylation of PI3K, AKT, and NF-kappaB p65, and the nuclear translocation of NF-kappaB p65.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	125-138
34090862-6	2021	Insulin-like growth factor-1 (IGF-1)-induced FDXR and PPARgamma expression and lipogenesis were abolished by pretreatment with PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	insulin like growth factor 1	Homo sapiens	0-28
34416638-10	2021	Moreover, Akt and mTOR inhibition by using LY294002 and rapamycin, respectively, blocked inflammatory cytokine overexpression induced by TCS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	thymoma viral proto-oncogene 1	Mus musculus	10-13
34416638-10	2021	Moreover, Akt and mTOR inhibition by using LY294002 and rapamycin, respectively, blocked inflammatory cytokine overexpression induced by TCS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	mechanistic target of rapamycin kinase	Mus musculus	18-22
34090862-6	2021	Insulin-like growth factor-1 (IGF-1)-induced FDXR and PPARgamma expression and lipogenesis were abolished by pretreatment with PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	insulin like growth factor 1	Homo sapiens	30-35
34090862-6	2021	Insulin-like growth factor-1 (IGF-1)-induced FDXR and PPARgamma expression and lipogenesis were abolished by pretreatment with PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	ferredoxin reductase	Homo sapiens	45-49
34090862-6	2021	Insulin-like growth factor-1 (IGF-1)-induced FDXR and PPARgamma expression and lipogenesis were abolished by pretreatment with PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	peroxisome proliferator activated receptor gamma	Homo sapiens	54-63
34354001-9	2021	Furthermore, the protective effects of PNS were abolished by HIF-1alpha inhibitor 2ME2 and PI3K/Akt inhibitor LY294002.PNS could reduce H9c2 hypoxia-reoxygenation injury by promoting autophagy and inhibiting apoptosis through HIF-1alpha/FOXO3a cell signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
34408780-5	2021	In addition, treatment of human malignant meningioma cells with the tyrosine protein kinase (c-MET) inhibitor (SU11274) or the phosphoinositide 3-kinase (PI3K) inhibitor (LY294002) suppressed HGF-induced migration and EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	127-152
34408780-5	2021	In addition, treatment of human malignant meningioma cells with the tyrosine protein kinase (c-MET) inhibitor (SU11274) or the phosphoinositide 3-kinase (PI3K) inhibitor (LY294002) suppressed HGF-induced migration and EMT.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	171-179	hepatocyte growth factor	Homo sapiens	192-195
34354001-9	2021	Furthermore, the protective effects of PNS were abolished by HIF-1alpha inhibitor 2ME2 and PI3K/Akt inhibitor LY294002.PNS could reduce H9c2 hypoxia-reoxygenation injury by promoting autophagy and inhibiting apoptosis through HIF-1alpha/FOXO3a cell signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	226-236
34354001-9	2021	Furthermore, the protective effects of PNS were abolished by HIF-1alpha inhibitor 2ME2 and PI3K/Akt inhibitor LY294002.PNS could reduce H9c2 hypoxia-reoxygenation injury by promoting autophagy and inhibiting apoptosis through HIF-1alpha/FOXO3a cell signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	forkhead box O3	Rattus norvegicus	237-243
34349085-10	2022	The effect of CIB1 knockdown on Ang II-induced cellular injury was comparable to that of LY294002, a specific inhibitor of the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	thymoma viral proto-oncogene 1	Mus musculus	132-135
34522167-5	2021	Specific inhibitor of the PI3K-Akt signaling cascade, LY294002 markedly inhibited the expression of p-Akt and significantly reduces the hypoxia-induced proliferation of cholesteatoma keratinocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	31-34
34413821-12	2021	Akt inhibitor LY294002 reversed the promotion of silencing GAS5 on ECM synthesis of degenerative NPCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	0-3
34413821-12	2021	Akt inhibitor LY294002 reversed the promotion of silencing GAS5 on ECM synthesis of degenerative NPCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	growth arrest specific 5	Homo sapiens	59-63
34522167-5	2021	Specific inhibitor of the PI3K-Akt signaling cascade, LY294002 markedly inhibited the expression of p-Akt and significantly reduces the hypoxia-induced proliferation of cholesteatoma keratinocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	AKT serine/threonine kinase 1	Homo sapiens	102-105
34184087-5	2021	LY294002 and insulin-like growth factor I (IGF-I) were used to inhibit and promote PI3K/AKT phosphorylation, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	insulin like growth factor 1	Homo sapiens	43-48
34131434-10	2021	However, PI3K/Akt inhibitor (LY294002) partially reduced the NRG induced phosphorylation of Akt and the reduction in beclin-1, along with the LC3BII/LC3BI ratio.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
34131434-10	2021	However, PI3K/Akt inhibitor (LY294002) partially reduced the NRG induced phosphorylation of Akt and the reduction in beclin-1, along with the LC3BII/LC3BI ratio.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Rattus norvegicus	92-95
34131434-10	2021	However, PI3K/Akt inhibitor (LY294002) partially reduced the NRG induced phosphorylation of Akt and the reduction in beclin-1, along with the LC3BII/LC3BI ratio.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	beclin 1	Rattus norvegicus	117-125
34218330-7	2021	RESULTS: From in vitro experiments, we found that CCL19 enhanced the frequencies of Ag-responsive IFN-gamma+ CD8+ T cells from patients by approximately twofold, while CCR7 knockdown (LV-shCCR7) and LY294002 partially suppressed IFN-gamma secretion.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	199-207	interferon gamma	Homo sapiens	229-238
34132431-6	2021	Furthermore, PI3K inhibitor LY294002 decreased expression of PI3K, p-PDK1, p-SGK1, and pro-caspase3 and SGK1 inhibitor GSK650394 also reduced expression of NF-kappaB and pro-caspase3 just like CK in HeLa cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	pyruvate dehydrogenase kinase 1	Homo sapiens	69-73
34132431-6	2021	Furthermore, PI3K inhibitor LY294002 decreased expression of PI3K, p-PDK1, p-SGK1, and pro-caspase3 and SGK1 inhibitor GSK650394 also reduced expression of NF-kappaB and pro-caspase3 just like CK in HeLa cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	serum/glucocorticoid regulated kinase 1	Homo sapiens	77-81
34132431-6	2021	Furthermore, PI3K inhibitor LY294002 decreased expression of PI3K, p-PDK1, p-SGK1, and pro-caspase3 and SGK1 inhibitor GSK650394 also reduced expression of NF-kappaB and pro-caspase3 just like CK in HeLa cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	caspase 3	Homo sapiens	87-99
34472270-8	2021	LY294002 blunted the promoting effect of Erxian Decoction on osteoblast proliferation and significantly down-regulated the expression of OPG and p-FoxO1, whereas its down-regulation on the expression of BMP-2 and p-Akt was not significant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	TNF receptor superfamily member 11B	Rattus norvegicus	137-140
34472270-8	2021	LY294002 blunted the promoting effect of Erxian Decoction on osteoblast proliferation and significantly down-regulated the expression of OPG and p-FoxO1, whereas its down-regulation on the expression of BMP-2 and p-Akt was not significant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	forkhead box O1	Rattus norvegicus	147-152
34472270-8	2021	LY294002 blunted the promoting effect of Erxian Decoction on osteoblast proliferation and significantly down-regulated the expression of OPG and p-FoxO1, whereas its down-regulation on the expression of BMP-2 and p-Akt was not significant.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	215-218
34472270-9	2021	Both LY294002 and Erxian Decoction increased the ALP activity of osteoblasts, which may be related to the cell state and the cell differentiation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	PDZ and LIM domain 3	Rattus norvegicus	49-52
34180121-6	2021	PUE was intraperitoneally administrated alone or with simultaneously intracerebroventricular injection of LY294002 (a specific inhibitor of the PI3K/Akt signal).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	AKT serine/threonine kinase 1	Rattus norvegicus	149-152
34326276-6	2021	Treatment of TRIB2-ovexpressed A2780 cells with the phosphoinositide-3-kinase inhibitor LY294002 abrogated TRIB2-stimulated proliferation, migration, drug resistance of A2780 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	tribbles pseudokinase 2	Homo sapiens	13-18
34326276-6	2021	Treatment of TRIB2-ovexpressed A2780 cells with the phosphoinositide-3-kinase inhibitor LY294002 abrogated TRIB2-stimulated proliferation, migration, drug resistance of A2780 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	tribbles pseudokinase 2	Homo sapiens	107-112
34184087-5	2021	LY294002 and insulin-like growth factor I (IGF-I) were used to inhibit and promote PI3K/AKT phosphorylation, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	88-91
34184087-7	2021	The present study found that LY294002 inhibited PI3K/AKT phosphorylation, decreased the proliferation and invasion of NOZ cells and suppressed the activity of ERRalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	AKT serine/threonine kinase 1	Homo sapiens	53-56
34184087-7	2021	The present study found that LY294002 inhibited PI3K/AKT phosphorylation, decreased the proliferation and invasion of NOZ cells and suppressed the activity of ERRalpha.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	estrogen related receptor alpha	Homo sapiens	159-167
34184087-9	2021	The protein expression levels of PGC-1alpha and PGC-1beta were elevated and reduced by IGF-I and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	PPARG coactivator 1 alpha	Homo sapiens	33-43
34184087-9	2021	The protein expression levels of PGC-1alpha and PGC-1beta were elevated and reduced by IGF-I and LY294002, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	PPARG coactivator 1 alpha	Homo sapiens	48-57
34275490-7	2021	In vitro organotypic culture-induced activation of the PI3K/PTEN/Akt pathway is counteracted by cryopreservation with rapamycin and in vitro culture in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	phosphatase and tensin homolog	Mus musculus	60-64
34366628-15	2021	Finally, YB-1 suppressed the inactivation of the PI3K/Akt signaling pathway induced by sorafenib, and the blockade of the PI3K/Akt signaling pathway by LY294002 mitigated YB-1-induced sorafenib resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	AKT serine/threonine kinase 1	Homo sapiens	127-130
34366628-15	2021	Finally, YB-1 suppressed the inactivation of the PI3K/Akt signaling pathway induced by sorafenib, and the blockade of the PI3K/Akt signaling pathway by LY294002 mitigated YB-1-induced sorafenib resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	Y-box binding protein 1	Homo sapiens	171-175
34275490-7	2021	In vitro organotypic culture-induced activation of the PI3K/PTEN/Akt pathway is counteracted by cryopreservation with rapamycin and in vitro culture in the presence of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	thymoma viral proto-oncogene 1	Mus musculus	65-68
34336047-11	2021	However, LY294002, a PI3K/AKT pathway inhibitor, reversed the functional roles of diazoxide in the proliferation ability of ASMCs in the rat model of asthma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Rattus norvegicus	26-29
34356525-5	2021	Pre-incubation of cells with the PI3K inhibitor Ly294002 or the ALK5 inhibitor SB431542 attenuated the decreased cell shortening in TGFbeta1-stimulated cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	48-56	transforming growth factor, beta 1	Mus musculus	132-140
34356525-6	2021	Additionally, TGFbeta-induced apoptosis was significantly reduced by the PI3K inhibitor Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	88-96	transforming growth factor alpha	Mus musculus	14-21
34356525-9	2021	Induction of SMAD binding activity and the TGFbeta target gene collagen 1 could be blocked by the PI3K inhibitor Ly294002, but not by the specific PI3Kgamma inhibitor AS605240.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	transforming growth factor alpha	Mus musculus	43-50
34238315-17	2021	The Akt/GSK-3beta/Snail signaling pathway was activated by overexpression of CHN1 in vitro, and activation of this pathway was inhibited by the signaling pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	AKT serine/threonine kinase 1	Homo sapiens	4-7
34326958-13	2021	LY294002 abolished the dcOC-mediated (1 h) promotion of Akt phosphorylation and glucose uptake without affecting GLUT1 protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	56-59
34299056-4	2021	We found that TIGAR expression was induced in stimulated lymphocytes through the PI3K/AKT pathway, since Akti-1/2 and LY294002 inhibitors prevented the upregulation of TIGAR in response to ConA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	14-19
34299056-4	2021	We found that TIGAR expression was induced in stimulated lymphocytes through the PI3K/AKT pathway, since Akti-1/2 and LY294002 inhibitors prevented the upregulation of TIGAR in response to ConA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	AKT serine/threonine kinase 1	Homo sapiens	86-89
34299056-4	2021	We found that TIGAR expression was induced in stimulated lymphocytes through the PI3K/AKT pathway, since Akti-1/2 and LY294002 inhibitors prevented the upregulation of TIGAR in response to ConA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	168-173
34238315-17	2021	The Akt/GSK-3beta/Snail signaling pathway was activated by overexpression of CHN1 in vitro, and activation of this pathway was inhibited by the signaling pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	glycogen synthase kinase 3 alpha	Homo sapiens	8-17
34238315-17	2021	The Akt/GSK-3beta/Snail signaling pathway was activated by overexpression of CHN1 in vitro, and activation of this pathway was inhibited by the signaling pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	snail family transcriptional repressor 1	Homo sapiens	18-23
34238315-17	2021	The Akt/GSK-3beta/Snail signaling pathway was activated by overexpression of CHN1 in vitro, and activation of this pathway was inhibited by the signaling pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	chimerin 1	Mus musculus	77-81
34295885-11	2021	We further demonstrated that the AKT activation was abolished by the use of a PI3K inhibitor (LY294002), which negatively affected STX2-mediated functions on trophoblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	AKT serine/threonine kinase 1	Homo sapiens	33-36
34295885-11	2021	We further demonstrated that the AKT activation was abolished by the use of a PI3K inhibitor (LY294002), which negatively affected STX2-mediated functions on trophoblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	syntaxin 2	Homo sapiens	131-135
34227646-6	2021	Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Homo sapiens	54-57
34227646-6	2021	Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	interleukin 1 alpha	Homo sapiens	256-264
34227646-6	2021	Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	interleukin 6	Homo sapiens	266-270
34227646-6	2021	Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	272-276
34227646-6	2021	Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	tumor necrosis factor	Homo sapiens	281-289
34227646-6	2021	Subsequently, it was demonstrated treatment with PI3K/AKT pathway inhibitor (LY294002) or Wnt/beta-catenin pathway inhibitor (Dickkopf-1, DKK-1) could further enhance the anti-inflammatory and antioxidant effects of RSV by downregulating the expression of IL-1beta, IL-6, IL-8 and TNFalpha, and the production of MDA, and increasing the activity of SOD and GSH-Px in LPS-induced HGFs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	superoxide dismutase 1	Homo sapiens	349-352
34182538-4	2021	Activated GPR30 increased extracellular HMGB1 secretion by CAFs, which was reduced by blocking PI3K/AKT signaling using G15 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
34307680-5	2021	Results: PI3K/AKT inhibitor LY294002 increased the rate of apoptosis in NP cells when compared to the control and decreased the proliferation rate when compared to control.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
34307680-7	2021	At the same time, LY294002 increased the protein expression level of MMP13 and Col-X in NP cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	matrix metallopeptidase 13	Rattus norvegicus	69-74
34087334-6	2021	Furthermore, inhibited PI3K/AKT pathway by LY294002 significantly abolished H2S-exerted the improvement of hippocampal neurogenesis and the antidepressant- and anxiolytic-like effects in the STZ-induced diabetic rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
34105305-10	2021	The PI3K inhibitor LY294002 treatment manifested similar effects as CERCAM silencing on bladder cancer cell behaviors and partially impaired the promotive functions of CERCAM overexpression upon the capacity of bladder cancer cells to proliferate and invade.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	cerebral endothelial cell adhesion molecule	Mus musculus	168-174
34307696-7	2021	Moreover, we found that application of acacetin increased activation of the PI3K/Akt signaling pathway, whereas cotreatment with the PI3K inhibitor LY294002 reversed the inhibition of apoptosis and autophagy induced by acacetin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	AKT serine/threonine kinase 1	Rattus norvegicus	81-84
34182538-4	2021	Activated GPR30 increased extracellular HMGB1 secretion by CAFs, which was reduced by blocking PI3K/AKT signaling using G15 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	high mobility group box 1	Homo sapiens	40-45
34182538-4	2021	Activated GPR30 increased extracellular HMGB1 secretion by CAFs, which was reduced by blocking PI3K/AKT signaling using G15 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	100-103
34154621-14	2021	Moreover, the promotion effects of Cornuside I on osteogenic differentiation of BMSCs were partially blocked by PI3K/Akt inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	132-140	AKT serine/threonine kinase 1	Homo sapiens	117-120
34118791-6	2021	However, these effects were largely attenuated by LY294002 (a specific Akt signaling blocker) administration.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	thymoma viral proto-oncogene 1	Mus musculus	71-74
34202670-6	2021	The MNG-induced expression of Nrf2, HO-1, and NQO1 were abolished by Nrf2 siRNA, while the MNG-induced expression of Nrf2 and HO-1 was abated and the AKT phosphorylation was blocked by LY294002 (a PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	NFE2 like bZIP transcription factor 2	Homo sapiens	30-34
34202670-6	2021	The MNG-induced expression of Nrf2, HO-1, and NQO1 were abolished by Nrf2 siRNA, while the MNG-induced expression of Nrf2 and HO-1 was abated and the AKT phosphorylation was blocked by LY294002 (a PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	heme oxygenase 1	Homo sapiens	36-40
34202670-6	2021	The MNG-induced expression of Nrf2, HO-1, and NQO1 were abolished by Nrf2 siRNA, while the MNG-induced expression of Nrf2 and HO-1 was abated and the AKT phosphorylation was blocked by LY294002 (a PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	NFE2 like bZIP transcription factor 2	Homo sapiens	117-121
34202670-6	2021	The MNG-induced expression of Nrf2, HO-1, and NQO1 were abolished by Nrf2 siRNA, while the MNG-induced expression of Nrf2 and HO-1 was abated and the AKT phosphorylation was blocked by LY294002 (a PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	heme oxygenase 1	Homo sapiens	126-130
34202670-6	2021	The MNG-induced expression of Nrf2, HO-1, and NQO1 were abolished by Nrf2 siRNA, while the MNG-induced expression of Nrf2 and HO-1 was abated and the AKT phosphorylation was blocked by LY294002 (a PI3K inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	AKT serine/threonine kinase 1	Homo sapiens	150-153
34202670-9	2021	The enhancement of Nrf2 and HO-1 by MNG upon H2O2 injury was reduced by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
34202670-9	2021	The enhancement of Nrf2 and HO-1 by MNG upon H2O2 injury was reduced by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	72-80	heme oxygenase 1	Homo sapiens	28-32
34306372-10	2021	Compared with the model group, the expression of PI3K/AKT/mTOR pathway related phosphorylated proteins, the proliferation and differentiation abilities of osteoblasts, the expression of autophagosome and autophagy related factors were all increased in the Naringin group, but contrary results were found in the LY294002 group (all P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	311-319	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
34306372-10	2021	Compared with the model group, the expression of PI3K/AKT/mTOR pathway related phosphorylated proteins, the proliferation and differentiation abilities of osteoblasts, the expression of autophagosome and autophagy related factors were all increased in the Naringin group, but contrary results were found in the LY294002 group (all P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	311-319	mechanistic target of rapamycin kinase	Rattus norvegicus	58-62
34164393-12	2021	The addition of LY294002 reversed the tumor growth induced by BCAT1 overexpression, further verifying this mechanism.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	branched chain amino acid transaminase 1	Homo sapiens	62-67
34258492-8	2021	Furthermore, the reintroduction and activation of TRbeta in ATC cell lines enables an increase in the efficacy of the competitive PI3K inhibitors LY294002 and buparlisib on cell viability, migration, and suppression of PI3K signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	146-154	T cell receptor alpha locus	Homo sapiens	50-56
33290316-2	2021	LY294002 was originally reported to be a selective inhibitor of PI3K-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	69-72
33290316-4	2021	In this study, we investigated the effect of LY294002 on the growth of suspension (MV4-11 and TF-1a) and tissue (Hep-G2) cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	45-53	tripartite motif containing 24	Homo sapiens	94-99
33290316-6	2021	LY294002 also significantly inhibited the proliferation of MV4-11, TF-1a and Hep-G2 cell and caused formation of cell clusters/aggregates measured by MTT and BrdU assays, and observed under an inverted microscope, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tripartite motif containing 24	Homo sapiens	67-72
33290316-7	2021	Surprisingly, we found that LY294002 markedly repressed the activation of mitogen-activated protein kinase (MAPK) signal molecules, MEK and ERK, in all these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	mitogen-activated protein kinase kinase 7	Homo sapiens	132-135
33290316-7	2021	Surprisingly, we found that LY294002 markedly repressed the activation of mitogen-activated protein kinase (MAPK) signal molecules, MEK and ERK, in all these cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	mitogen-activated protein kinase 1	Homo sapiens	140-143
33290316-11	2021	Our data suggest that LY294002 may directly inhibit the activation of MEK and ERK by its ability to bind to the ATP-binding site of the MAPK molecules.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	mitogen-activated protein kinase kinase 7	Homo sapiens	70-73
33290316-11	2021	Our data suggest that LY294002 may directly inhibit the activation of MEK and ERK by its ability to bind to the ATP-binding site of the MAPK molecules.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	mitogen-activated protein kinase 1	Homo sapiens	78-81
34105476-6	2021	In addition, the PI3K/Akt signaling pathway-specific inhibitor LY294002 and TRIM31-shRNA lentivirus were used to interfere with U266 cells, and the cell proliferation, apoptosis, and protein expression of p-Akt (Ser473) and Akt were detected by CCK-8, flow cytometry and Western blot, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	AKT serine/threonine kinase 1	Homo sapiens	22-25
33269749-11	2021	Both LY294002 (20 muM) and rapamycin (500 nM), which are inhibitors of the PI3K/Akt/mTOR pathway, significantly attenuated the inhibition of autophagy and apoptosis caused by apelin-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	AKT serine/threonine kinase 1	Homo sapiens	80-83
33269749-11	2021	Both LY294002 (20 muM) and rapamycin (500 nM), which are inhibitors of the PI3K/Akt/mTOR pathway, significantly attenuated the inhibition of autophagy and apoptosis caused by apelin-13.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	mechanistic target of rapamycin kinase	Homo sapiens	84-88
34105476-11	2021	Intervention of LY294002 significantly enhanced the inhibition on cell proliferation and the promotion on apoptosis mediated by TRIM31 gene silencing in U266 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	tripartite motif containing 31	Homo sapiens	128-134
34071138-7	2021	Furthermore, insulin-increased MBP expression was significantly suppressed by the addition of LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	myelin basic protein	Rattus norvegicus	31-34
34162041-5	2021	Also, AGEs upregulated the expression of osteoprotegerin and bone morphogenetic protein, and these effects were suppressed by LY294002 but enhanced by TWS119.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	TNF receptor superfamily member 11b	Homo sapiens	41-56
34162041-5	2021	Also, AGEs upregulated the expression of osteoprotegerin and bone morphogenetic protein, and these effects were suppressed by LY294002 but enhanced by TWS119.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	bone morphogenetic protein 1	Homo sapiens	61-87
34556263-8	2021	Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
34084134-12	2021	Moreover, the preservation of APN expression was reversed by LY294002 (a PI3K/AKT signaling pathway inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	30-33
34084134-12	2021	Moreover, the preservation of APN expression was reversed by LY294002 (a PI3K/AKT signaling pathway inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
34095301-8	2021	Additionally, the vasorelaxation activity of GPS was attenuated upon pretreatment with LY294002 (PI3K/Akt inhibitor), Y27632 (Rho-kinase inhibitor), and verapamil (L-type Ca2+ channel inhibitor).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
34556263-8	2021	Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	forkhead box O1	Rattus norvegicus	99-104
34556263-9	2021	Furthermore, saponins increased the protein level of the downstream molecule and insulin initiating factor PDX-1, which was also reversed by ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	141-149	pancreatic and duodenal homeobox 1	Rattus norvegicus	107-112
34556263-10	2021	Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	AKT serine/threonine kinase 1	Rattus norvegicus	24-27
34556263-10	2021	Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	pancreatic and duodenal homeobox 1	Rattus norvegicus	32-37
34556263-10	2021	Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	forkhead box O1	Rattus norvegicus	57-62
35533447-10	2022	Moreover, inhibiting PI3K-AKT by LY294002 abrogated nicotine-mediated beta-catenin level increase and thymopoiesis abnormalities, and an alpha7 nAChR antagonist (alpha-btx) also reversed nicotine-induced PI3K-AKT activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	thymoma viral proto-oncogene 1	Mus musculus	26-29
35575872-11	2022	We used LY294002 to block PI3K and the results showed that CTS exerted neuroprotective effects through regulation of the PI3K/Akt/GSK3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	thymoma viral proto-oncogene 1	Mus musculus	126-129
35575872-11	2022	We used LY294002 to block PI3K and the results showed that CTS exerted neuroprotective effects through regulation of the PI3K/Akt/GSK3beta signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	8-16	glycogen synthase kinase 3 alpha	Mus musculus	130-138
35582997-3	2022	The present study aimed to evaluate the regulatory effect of the Notch1/hairy and enhancer of split 1 (Hes1)-PTEN/AKT/IL-17A feedback loop on Th17 cell differentiation via the PI3K/AKT inhibitor LY294002 in a mouse model of psoriasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	hes family bHLH transcription factor 1	Mus musculus	65-101
35582997-3	2022	The present study aimed to evaluate the regulatory effect of the Notch1/hairy and enhancer of split 1 (Hes1)-PTEN/AKT/IL-17A feedback loop on Th17 cell differentiation via the PI3K/AKT inhibitor LY294002 in a mouse model of psoriasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	hes family bHLH transcription factor 1	Mus musculus	103-107
35582997-3	2022	The present study aimed to evaluate the regulatory effect of the Notch1/hairy and enhancer of split 1 (Hes1)-PTEN/AKT/IL-17A feedback loop on Th17 cell differentiation via the PI3K/AKT inhibitor LY294002 in a mouse model of psoriasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	phosphatase and tensin homolog	Mus musculus	109-113
35582997-3	2022	The present study aimed to evaluate the regulatory effect of the Notch1/hairy and enhancer of split 1 (Hes1)-PTEN/AKT/IL-17A feedback loop on Th17 cell differentiation via the PI3K/AKT inhibitor LY294002 in a mouse model of psoriasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	thymoma viral proto-oncogene 1	Mus musculus	114-117
35582997-3	2022	The present study aimed to evaluate the regulatory effect of the Notch1/hairy and enhancer of split 1 (Hes1)-PTEN/AKT/IL-17A feedback loop on Th17 cell differentiation via the PI3K/AKT inhibitor LY294002 in a mouse model of psoriasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	interleukin 17A	Mus musculus	118-124
35582997-3	2022	The present study aimed to evaluate the regulatory effect of the Notch1/hairy and enhancer of split 1 (Hes1)-PTEN/AKT/IL-17A feedback loop on Th17 cell differentiation via the PI3K/AKT inhibitor LY294002 in a mouse model of psoriasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	195-203	thymoma viral proto-oncogene 1	Mus musculus	181-184
35582997-8	2022	Additionally, splenic mononuclear cells from model mice were treated by 10 and 50 microM LY294002 to further evaluate its regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	notch 1	Mus musculus	143-149
35582997-8	2022	Additionally, splenic mononuclear cells from model mice were treated by 10 and 50 microM LY294002 to further evaluate its regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	hes family bHLH transcription factor 1	Mus musculus	150-154
35582997-8	2022	Additionally, splenic mononuclear cells from model mice were treated by 10 and 50 microM LY294002 to further evaluate its regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	phosphatase and tensin homolog	Mus musculus	155-159
35582997-8	2022	Additionally, splenic mononuclear cells from model mice were treated by 10 and 50 microM LY294002 to further evaluate its regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	thymoma viral proto-oncogene 1	Mus musculus	160-163
35582997-8	2022	Additionally, splenic mononuclear cells from model mice were treated by 10 and 50 microM LY294002 to further evaluate its regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	89-97	interleukin 17A	Mus musculus	164-170
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	notch 1	Mus musculus	116-122
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	hes family bHLH transcription factor 1	Mus musculus	131-135
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	thymoma viral proto-oncogene 1	Mus musculus	137-140
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	thymoma viral proto-oncogene 1	Mus musculus	144-147
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	CREB regulated transcription coactivator 1	Mus musculus	149-155
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	CREB regulated transcription coactivator 1	Mus musculus	159-165
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	167-171
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	ribosomal protein S6 kinase, polypeptide 2	Mus musculus	173-177
34076985-10	2021	Notably, inhibitory effects of Baicalein treatment on MMP levels and invasiveness in glioma were blocked by the application of LY294002 (PI3K/Akt inhibitor), and stimulated by the application of IGF-1 (PI3K/Akt activator).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	matrix metallopeptidase 2	Homo sapiens	54-57
34076985-10	2021	Notably, inhibitory effects of Baicalein treatment on MMP levels and invasiveness in glioma were blocked by the application of LY294002 (PI3K/Akt inhibitor), and stimulated by the application of IGF-1 (PI3K/Akt activator).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	AKT serine/threonine kinase 1	Homo sapiens	142-145
34775933-11	2021	Moreover, Ginsenoside Rb1 treatment resulted in the activation of the PI3K/Akt/mTOR pathway, and treatment of LY294002 (PI3K/Akt pathway repressor) abolished the protective effects of Ginsenoside Rb1 on myocardial in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	AKT serine/threonine kinase 1	Rattus norvegicus	125-128
34775933-11	2021	Moreover, Ginsenoside Rb1 treatment resulted in the activation of the PI3K/Akt/mTOR pathway, and treatment of LY294002 (PI3K/Akt pathway repressor) abolished the protective effects of Ginsenoside Rb1 on myocardial in vitro and in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	RB transcriptional corepressor 1	Rattus norvegicus	196-199
34284400-9	2021	RESULTS: The results demonstrated that TGF-beta1, simultaneous with the induction of MF differentiation, confers significant protection against anoikis-induced cell death, which could be partly reversed by treatment with the PI3K/Akt pathway inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	253-261	transforming growth factor beta 1	Homo sapiens	39-48
34284400-9	2021	RESULTS: The results demonstrated that TGF-beta1, simultaneous with the induction of MF differentiation, confers significant protection against anoikis-induced cell death, which could be partly reversed by treatment with the PI3K/Akt pathway inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	253-261	AKT serine/threonine kinase 1	Homo sapiens	230-233
35367329-12	2022	Finally, the inhibitory effect of BYF on renal fibrogenesis was not enhanced while blocking the PI3K/AKT pathway with a broad spectrum PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	151-159	AKT serine/threonine kinase 1	Rattus norvegicus	101-104
35500642-11	2022	NAC, LY294002 and PDTC treatment resulted in reduced nuclear translocation of NF-kappaB and decreased expression of inflammatory markers in HG treated ARPE-19 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	nuclear factor kappa B subunit 1	Homo sapiens	78-87
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	interleukin 17A	Mus musculus	182-188
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	phosphatase and tensin homolog	Mus musculus	222-226
35582997-12	2022	In vitro study from 5% IMQ-induced mouse splenic mononuclear cells presented that high dose of LY294002 exerted more obviously regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	notch 1	Mus musculus	148-154
35582997-12	2022	In vitro study from 5% IMQ-induced mouse splenic mononuclear cells presented that high dose of LY294002 exerted more obviously regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	hes family bHLH transcription factor 1	Mus musculus	155-159
35582997-12	2022	In vitro study from 5% IMQ-induced mouse splenic mononuclear cells presented that high dose of LY294002 exerted more obviously regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	phosphatase and tensin homolog	Mus musculus	160-164
35582997-12	2022	In vitro study from 5% IMQ-induced mouse splenic mononuclear cells presented that high dose of LY294002 exerted more obviously regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	thymoma viral proto-oncogene 1	Mus musculus	165-168
35582997-12	2022	In vitro study from 5% IMQ-induced mouse splenic mononuclear cells presented that high dose of LY294002 exerted more obviously regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	95-103	interleukin 17A	Mus musculus	169-175
35533447-10	2022	Moreover, inhibiting PI3K-AKT by LY294002 abrogated nicotine-mediated beta-catenin level increase and thymopoiesis abnormalities, and an alpha7 nAChR antagonist (alpha-btx) also reversed nicotine-induced PI3K-AKT activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	catenin (cadherin associated protein), beta 1	Mus musculus	70-82
35584953-12	2022	These phenomena were accompanied by the downregulation of p-JAK2, p-STAT3, p-AKT, GP130, and IL-6, which were abolished by the co-administration of PI3K (ly294002) or STAT3 (stattic) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	Janus kinase 2	Rattus norvegicus	60-64
35584953-12	2022	These phenomena were accompanied by the downregulation of p-JAK2, p-STAT3, p-AKT, GP130, and IL-6, which were abolished by the co-administration of PI3K (ly294002) or STAT3 (stattic) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	signal transducer and activator of transcription 3	Rattus norvegicus	68-73
35584953-12	2022	These phenomena were accompanied by the downregulation of p-JAK2, p-STAT3, p-AKT, GP130, and IL-6, which were abolished by the co-administration of PI3K (ly294002) or STAT3 (stattic) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	AKT serine/threonine kinase 1	Rattus norvegicus	77-80
35584953-12	2022	These phenomena were accompanied by the downregulation of p-JAK2, p-STAT3, p-AKT, GP130, and IL-6, which were abolished by the co-administration of PI3K (ly294002) or STAT3 (stattic) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	interleukin 6 cytokine family signal transducer	Rattus norvegicus	82-87
35584953-12	2022	These phenomena were accompanied by the downregulation of p-JAK2, p-STAT3, p-AKT, GP130, and IL-6, which were abolished by the co-administration of PI3K (ly294002) or STAT3 (stattic) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	interleukin 6	Rattus norvegicus	93-97
35461041-9	2022	The agonist 740Y-P and inhibitor LY294002 reversed the effect of KB-1980E6.3 knockdown and overexpression on the PI3K/AKT pathway in BC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	AKT serine/threonine kinase 1	Homo sapiens	118-121
35359221-7	2022	Furthermore, the phosphorylation of STAT3 was significantly downregulated by the inhibition of Akt (LY294002, 10 muM) in OGD/R and sRAGE treated cardiomyocytes, which suggested that STAT3 pathway was induced by Akt in I/R and sRAGE treated cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	signal transducer and activator of transcription 3	Mus musculus	36-41
35359221-7	2022	Furthermore, the phosphorylation of STAT3 was significantly downregulated by the inhibition of Akt (LY294002, 10 muM) in OGD/R and sRAGE treated cardiomyocytes, which suggested that STAT3 pathway was induced by Akt in I/R and sRAGE treated cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	thymoma viral proto-oncogene 1	Mus musculus	95-98
35359221-7	2022	Furthermore, the phosphorylation of STAT3 was significantly downregulated by the inhibition of Akt (LY294002, 10 muM) in OGD/R and sRAGE treated cardiomyocytes, which suggested that STAT3 pathway was induced by Akt in I/R and sRAGE treated cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	signal transducer and activator of transcription 3	Mus musculus	182-187
35359221-7	2022	Furthermore, the phosphorylation of STAT3 was significantly downregulated by the inhibition of Akt (LY294002, 10 muM) in OGD/R and sRAGE treated cardiomyocytes, which suggested that STAT3 pathway was induced by Akt in I/R and sRAGE treated cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	thymoma viral proto-oncogene 1	Mus musculus	211-214
35567290-10	2022	In vitro, HQR inhibited H9c2 cells apoptosis, improved mitochondrial function and activated the PI3K/Akt/Bad pathway, but effects can be peripeteiad by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	152-160	AKT serine/threonine kinase 1	Rattus norvegicus	101-104
35605918-12	2022	The mechanism underlying the effect of DPH5 in alleviating IR was related to the PI3K/AKT- and Nrf2/HO-1-mediated regulation of the GSK3beta signaling pathway, and the results were further confirmed using the specific inhibitors LY294002 and ML385.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	diphthamide biosynthesis 5	Homo sapiens	39-43
35413475-10	2022	In addition, our rescuing experiments verified that miR-K12-1 promoted cell proliferation via activating the PI3K/Akt pathway, and inhibition of the PI3K/Akt pathway by LY294002 abrogated the tumor-promoting effects of miR-K12-1 in HIV-related gastrointestinal KS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	169-177	AKT serine/threonine kinase 1	Homo sapiens	154-157
35593529-4	2022	PI3K inhibition by LY294002 treatment blocked the stimulation of Ile on BRG1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Bos taurus	72-76
35623361-8	2022	However, although LY294002 can achieve the same inhibitory effect as TLR4 siRNA by blocking the PI3K/AKT signaling pathway, it could not affect the expression of TLR4.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	101-104
35605918-12	2022	The mechanism underlying the effect of DPH5 in alleviating IR was related to the PI3K/AKT- and Nrf2/HO-1-mediated regulation of the GSK3beta signaling pathway, and the results were further confirmed using the specific inhibitors LY294002 and ML385.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	AKT serine/threonine kinase 1	Homo sapiens	86-89
35605918-12	2022	The mechanism underlying the effect of DPH5 in alleviating IR was related to the PI3K/AKT- and Nrf2/HO-1-mediated regulation of the GSK3beta signaling pathway, and the results were further confirmed using the specific inhibitors LY294002 and ML385.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
35605918-12	2022	The mechanism underlying the effect of DPH5 in alleviating IR was related to the PI3K/AKT- and Nrf2/HO-1-mediated regulation of the GSK3beta signaling pathway, and the results were further confirmed using the specific inhibitors LY294002 and ML385.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	heme oxygenase 1	Homo sapiens	100-104
35605918-12	2022	The mechanism underlying the effect of DPH5 in alleviating IR was related to the PI3K/AKT- and Nrf2/HO-1-mediated regulation of the GSK3beta signaling pathway, and the results were further confirmed using the specific inhibitors LY294002 and ML385.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	229-237	glycogen synthase kinase 3 alpha	Homo sapiens	132-140
35607451-15	2022	To determine whether AKT phosphorylation at serine 473 induced beta-catenin nuclear translocation through GSK3beta phosphorylation at serine 9, the PI3K/AKT inhibitor LY294002 was cotreated with melatonin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	catenin beta 1	Homo sapiens	63-75
35607451-15	2022	To determine whether AKT phosphorylation at serine 473 induced beta-catenin nuclear translocation through GSK3beta phosphorylation at serine 9, the PI3K/AKT inhibitor LY294002 was cotreated with melatonin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	167-175	AKT serine/threonine kinase 1	Homo sapiens	153-156
35607451-16	2022	Immunoblotting showed that LY294002 inhibited melatonin-induced phosphorylation of GSK3beta at serine 9 residue and beta-catenin activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	glycogen synthase kinase 3 alpha	Homo sapiens	83-91
35607451-16	2022	Immunoblotting showed that LY294002 inhibited melatonin-induced phosphorylation of GSK3beta at serine 9 residue and beta-catenin activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	catenin beta 1	Homo sapiens	116-128
35581606-25	2022	The pathway inhibitor LY294002 blocked the TEAD4-induced enhancement of migration and invasion as well as the expression EMT-related markers, whereas the agonist 740Y-P rescued the decreased migration, invasion and EMT induced by TEAD4 knockdown.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	22-30	TEA domain family member 4	Mus musculus	43-48
35605400-9	2022	Co-addition of LY294002, an inhibitor of PI3-kinase occluded IL-10 action on Ileak and Rin showing involvement of PI3K-associated pathway in IL-10 mediated regulation of TASK channel function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	interleukin 10	Homo sapiens	61-66
35581378-7	2022	Pharmacological kinase inhibition with LY294002 (a PI3K inhibitor), U0126 (a MEK/ERK inhibitor), or PP2 (a Src family kinase inhibitor) resulted in impaired ZO-1 expression at both transcript and protein levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	tight junction protein 1	Homo sapiens	157-161
35574901-10	2022	The ERK1/2 inhibitor (U0126) and PI3K inhibitor (LY294002) significantly reduced LIPUS-induced phosphorylation of ERK1/2 and PI3K-Akt, respectively, which in turn reduced the LIPUS-induced viability of H9C2s in 3D bio-printed cell-laden GelMA scaffolds.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	mitogen activated protein kinase 3	Rattus norvegicus	114-120
35574901-10	2022	The ERK1/2 inhibitor (U0126) and PI3K inhibitor (LY294002) significantly reduced LIPUS-induced phosphorylation of ERK1/2 and PI3K-Akt, respectively, which in turn reduced the LIPUS-induced viability of H9C2s in 3D bio-printed cell-laden GelMA scaffolds.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	AKT serine/threonine kinase 1	Rattus norvegicus	130-133
35602302-12	2022	Pretreatment with LY294002 significantly restored iHAX-1-induced decline in PI3K/AKT/mTOR/eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Homo sapiens	81-84
35568058-12	2022	In order to further illustrate this point, we added the broad-spectrum phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 to NS20Y cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	71-100
35602302-12	2022	Pretreatment with LY294002 significantly restored iHAX-1-induced decline in PI3K/AKT/mTOR/eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	mechanistic target of rapamycin kinase	Homo sapiens	85-89
35602302-12	2022	Pretreatment with LY294002 significantly restored iHAX-1-induced decline in PI3K/AKT/mTOR/eNOS phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	nitric oxide synthase 3	Homo sapiens	90-94
35592867-12	2022	In addition, E2F1 induced LINC00152 overexpression, which accelerated cell proliferation, migration, and invasion by activating the PI3K/AKT axis, whereas the administration of LY294002, the inhibitor of PI3K, led to reversal of the same.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	E2F transcription factor 1 L homeolog	Xenopus laevis	13-17
35567927-9	2022	A PI3K inhibitor (LY294002) blocked the PI3K/Akt signaling pathway and reversed the effects of sipeimine.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	45-48
35592867-12	2022	In addition, E2F1 induced LINC00152 overexpression, which accelerated cell proliferation, migration, and invasion by activating the PI3K/AKT axis, whereas the administration of LY294002, the inhibitor of PI3K, led to reversal of the same.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	177-185	cytoskeleton regulator RNA	Homo sapiens	26-35
35592867-13	2022	Finally, xenograft transplantation validated that E2F1 inhibition could suppress LY294002, thereby discouraging tumor growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	E2F transcription factor 1 L homeolog	Xenopus laevis	50-54
35550264-7	2022	Moreover, the potential underlying mechanisms were uncovered, and we illustrated that sevoflurane promoted GSK-3beta activation in LPS-treated ALI mice lung tissues, and re-activation of GSK-3beta by the PI3K/Akt pathway inhibitor LY294002 suppressed LPS-induced pyroptotic cell death in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	231-239	glycogen synthase kinase 3 alpha	Mus musculus	187-196
35538534-9	2022	To identify signaling molecules regulating Smurf2 expression by LPA, pharmacological inhibitors such as A6370 (Akt1/2 kinase inhibitor) and Ly 294002 (PI3K inhibitor) were used.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	140-149	SMAD specific E3 ubiquitin protein ligase 2	Mus musculus	43-49
35550264-7	2022	Moreover, the potential underlying mechanisms were uncovered, and we illustrated that sevoflurane promoted GSK-3beta activation in LPS-treated ALI mice lung tissues, and re-activation of GSK-3beta by the PI3K/Akt pathway inhibitor LY294002 suppressed LPS-induced pyroptotic cell death in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	231-239	thymoma viral proto-oncogene 1	Mus musculus	209-212
35514261-6	2022	As previously shown, LY294002 and ARC69931MX abolished 2MeSADP-induced Akt phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	AKT serine/threonine kinase 1	Homo sapiens	71-74
35514261-8	2022	Rap1b activation, however, was only reduced, but not ablated, using LY294002 and was completely inhibited by ARC69931MX or MRS2179.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	RAP1B, member of RAS oncogene family	Homo sapiens	0-5
35489106-11	2022	The protective and pro-autophagy activity of Vaspin was antagonized by the PI3K/AKT-mTOR inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	serpin family A member 12	Rattus norvegicus	45-51
35503228-10	2022	Moreover, PI3K/AKT signaling inhibitor LY294002 reversed KAT5 overexpression-mediated phenotypes and inflammatory response after induction AC in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	thymoma viral proto-oncogene 1	Mus musculus	15-18
35503228-10	2022	Moreover, PI3K/AKT signaling inhibitor LY294002 reversed KAT5 overexpression-mediated phenotypes and inflammatory response after induction AC in vivo.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	K(lysine) acetyltransferase 5	Mus musculus	57-61
35489106-11	2022	The protective and pro-autophagy activity of Vaspin was antagonized by the PI3K/AKT-mTOR inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	AKT serine/threonine kinase 1	Rattus norvegicus	80-83
35489106-11	2022	The protective and pro-autophagy activity of Vaspin was antagonized by the PI3K/AKT-mTOR inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	mechanistic target of rapamycin kinase	Rattus norvegicus	84-88
35378205-7	2022	Inhibition of autophagy or Akt pathways by chloroquine (CQ), 3-Methyladenine (3-MA) or LY294002 promoted colistin-induced mitochondrial damage, and caspase-dependent cellular apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	87-95	thymoma viral proto-oncogene 1	Mus musculus	27-30
35001339-10	2022	Importantly, the PI3K/AKT inhibitor LY294002 strongly abolished the role of shVLCAD in HCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	AKT serine/threonine kinase 1	Homo sapiens	22-25
35510038-11	2022	Mechanically, HG-enhanced ALP activity, AKT, and ERK phosphorylation were inhibited by LIRA, PI3K antagonist LY294002, or ERK1/2 antagonist PD98059, in which cotreatment of LIRA with LY294002 and PD98059 could further enhance the effect of LIRA on VSMC, and GLP-1R antagonists reversed the phenotypes in the model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	AKT serine/threonine kinase 1	Rattus norvegicus	40-43
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	AKT serine/threonine kinase 1	Rattus norvegicus	46-49
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	mechanistic target of rapamycin kinase	Rattus norvegicus	50-54
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	mechanistic target of rapamycin kinase	Rattus norvegicus	170-174
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	AKT serine/threonine kinase 1	Rattus norvegicus	270-273
35438806-8	2022	Mechanistically, poly(I:C) activated the PI3K/AKT/mTOR pathway to induce autophagy, which was abolished by LY294002 (PI3K antagonist), rapamycin (autophagy activator and mTOR inhibitor), or 3-methyladenine (autophagy inhibitor), suggesting either inhibition of the PI3K/Akt/mTOR pathway or autophagy activity interrupt the beneficial effect of poly(I:C) preconditioning.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	mechanistic target of rapamycin kinase	Rattus norvegicus	274-278
35149293-10	2022	The phenomenon, which was dependent on PI3K/AKT/mTOR and TGF-beta/SMAD signaling, could be blocked by LY294002 and LY2109761.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	AKT serine/threonine kinase 1	Homo sapiens	44-47
35149293-10	2022	The phenomenon, which was dependent on PI3K/AKT/mTOR and TGF-beta/SMAD signaling, could be blocked by LY294002 and LY2109761.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	mechanistic target of rapamycin kinase	Homo sapiens	48-52
35149293-10	2022	The phenomenon, which was dependent on PI3K/AKT/mTOR and TGF-beta/SMAD signaling, could be blocked by LY294002 and LY2109761.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	transforming growth factor alpha	Homo sapiens	57-65
34558536-7	2022	These effects on Bax, Bcl-2, and Caspase-3 were blocked by pretreatment with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	BCL2 associated X, apoptosis regulator	Homo sapiens	17-20
34558536-7	2022	These effects on Bax, Bcl-2, and Caspase-3 were blocked by pretreatment with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	BCL2 apoptosis regulator	Homo sapiens	22-27
34558536-7	2022	These effects on Bax, Bcl-2, and Caspase-3 were blocked by pretreatment with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	caspase 3	Homo sapiens	33-42
35181349-11	2022	Treatment with the MAS receptor antagonist A779 and the Akt antagonist LY294002 reversed the effects of Ang-(1-7) on iNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	AKT serine/threonine kinase 1	Rattus norvegicus	56-59
35181349-11	2022	Treatment with the MAS receptor antagonist A779 and the Akt antagonist LY294002 reversed the effects of Ang-(1-7) on iNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	angiogenin	Rattus norvegicus	104-112
35181349-11	2022	Treatment with the MAS receptor antagonist A779 and the Akt antagonist LY294002 reversed the effects of Ang-(1-7) on iNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	71-79	nitric oxide synthase 2	Rattus norvegicus	117-121
35487953-8	2022	PI3K-AKT pathway inhibitor LY294002 reversed the excessive activation and phagocytosis of microglia caused by sTREM-1 in vivo and in vitro, which in turn improved the hippocampus damage.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	thymoma viral proto-oncogene 1	Mus musculus	5-8
35478128-11	2022	The PI3K/Akt-pathway inhibitor, LY294002, did not significantly affect micromass growth but significantly decreased mineralization (p<0.001).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	9-12
35218761-10	2022	Finally, an AKT inhibitor (LY294002) was used to pretreat hPDLCs before rSEMA7A stimulation to determine the role of AKT signaling activation in this process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	12-15
35218761-13	2022	Furthermore, we found that the proinflammatory role of SEMA7A could be inhibited by the application of the AKT inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A	Mus musculus	55-61
35218761-13	2022	Furthermore, we found that the proinflammatory role of SEMA7A could be inhibited by the application of the AKT inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	122-130	AKT serine/threonine kinase 1	Homo sapiens	107-110
35190952-9	2022	The expressions of PI3K and Akt were significantly downregulated by PMS + CUMS processes but upregulated by CSS treatment, which could be significantly suppressed by Ly294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	166-174	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
35574325-6	2022	Treatment with LY294002 and 740 Y-P reversed the impact upregulation and downregulation of ECM1 on CRC cell metastasis and associated EMT induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	extracellular matrix protein 1	Homo sapiens	91-95
35510038-11	2022	Mechanically, HG-enhanced ALP activity, AKT, and ERK phosphorylation were inhibited by LIRA, PI3K antagonist LY294002, or ERK1/2 antagonist PD98059, in which cotreatment of LIRA with LY294002 and PD98059 could further enhance the effect of LIRA on VSMC, and GLP-1R antagonists reversed the phenotypes in the model.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	Eph receptor B1	Rattus norvegicus	49-52
35352734-6	2022	The addition of 0.25 mmol L-1 GlcN enhanced the phosphorylation of mTOR signaling proteins, which can be inhibited by the inhibitor of phosphatidylinositol 3-kinase (PI3K), LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	mechanistic target of rapamycin kinase	Homo sapiens	67-71
35458602-3	2022	The top hit 3s seemed more potent than the positive control LY294002 on inhibiting PI3Kgamma (IC50 values: 0.066 muM versus 0.777 muM) and more selective from PI3Kalpha (Index values: 645 versus 1.74).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	83-92
35394554-5	2022	In cultured podocytes, we used plasmids to knockdown FKN and treated the podocytes with PI3K/Akt inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	108-116	thymoma viral proto-oncogene 1	Mus musculus	93-96
35394554-10	2022	FKN knockdown reduced podocyte apoptosis by regulating the Bcl-2 family; however, this protective effect was reversed by the co-administration of a PI3K/Akt inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	chemokine (C-X3-C motif) ligand 1	Mus musculus	0-3
35394554-10	2022	FKN knockdown reduced podocyte apoptosis by regulating the Bcl-2 family; however, this protective effect was reversed by the co-administration of a PI3K/Akt inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	168-176	thymoma viral proto-oncogene 1	Mus musculus	153-156
35420711-7	2022	The insulin/PI3K/Akt signaling pathway can significantly irritate the hematopoiesis, and its inhibitor LY294002 could inhibit the hemocytes discharged from HPOs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	RAC serine/threonine-protein kinase	Bombyx mori	17-20
35179214-13	2022	In addition, LY294002 partially reversed the regulation of wogonin on NOX2, caspase-3, Bax and Bcl-2 proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cytochrome b-245 beta chain	Rattus norvegicus	70-74
35261236-8	2022	When the AKT pathway was inhibited by LY294002, the neurogenerative and antioxidant effects of melatonin were significantly limited in the hippocampus of miR-144/451-/- mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	thymoma viral proto-oncogene 1	Mus musculus	9-12
35129008-8	2022	Treatment of FL cells with LY294002, the inhibitor of Akt, could delete the MF-induced SK1 activation under the condition of calcium-free medium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Homo sapiens	54-57
35129008-8	2022	Treatment of FL cells with LY294002, the inhibitor of Akt, could delete the MF-induced SK1 activation under the condition of calcium-free medium.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	sphingosine kinase 1	Homo sapiens	87-90
35066448-13	2022	Moreover, activated PI3K/AKT signaling in HK-2 cells was inhibited by PK and the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	thymoma viral proto-oncogene 1	Mus musculus	25-28
35333664-6	2022	Finally, after the addition of P13K/Akt pathway inhibitor LY294002, cell apoptosis, ECM and inflammation in KuA-treated NPCs induced by LPS were again examined by the same methods.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-66	AKT serine/threonine kinase 1	Homo sapiens	36-39
35179214-13	2022	In addition, LY294002 partially reversed the regulation of wogonin on NOX2, caspase-3, Bax and Bcl-2 proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	caspase 3	Rattus norvegicus	76-85
35179214-13	2022	In addition, LY294002 partially reversed the regulation of wogonin on NOX2, caspase-3, Bax and Bcl-2 proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	87-90
35179214-13	2022	In addition, LY294002 partially reversed the regulation of wogonin on NOX2, caspase-3, Bax and Bcl-2 proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	BCL2, apoptosis regulator	Rattus norvegicus	95-100
35354939-6	2022	The following mechanisms were explored using a specific PI3K/AKT pathway inhibitor (Ly294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	thymoma viral proto-oncogene 1	Mus musculus	61-64
35218109-6	2022	The PI3K/AKT signaling pathway suppressor, LY294002, was applied to treat the cells and the changes of KCNQ1OT1 expression and LOXL2, p-AKT, and AKT protein expressions were examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	9-12
35218109-6	2022	The PI3K/AKT signaling pathway suppressor, LY294002, was applied to treat the cells and the changes of KCNQ1OT1 expression and LOXL2, p-AKT, and AKT protein expressions were examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	103-111
35218109-6	2022	The PI3K/AKT signaling pathway suppressor, LY294002, was applied to treat the cells and the changes of KCNQ1OT1 expression and LOXL2, p-AKT, and AKT protein expressions were examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	lysyl oxidase like 2	Homo sapiens	127-132
35218109-6	2022	The PI3K/AKT signaling pathway suppressor, LY294002, was applied to treat the cells and the changes of KCNQ1OT1 expression and LOXL2, p-AKT, and AKT protein expressions were examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	136-139
35218109-6	2022	The PI3K/AKT signaling pathway suppressor, LY294002, was applied to treat the cells and the changes of KCNQ1OT1 expression and LOXL2, p-AKT, and AKT protein expressions were examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	AKT serine/threonine kinase 1	Homo sapiens	145-148
35218109-13	2022	Additionally, LY294002 treatment caused low KCNQ1OT1 RNA expression and decreased LOXL2 and p-AKT protein expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	44-52
35218109-13	2022	Additionally, LY294002 treatment caused low KCNQ1OT1 RNA expression and decreased LOXL2 and p-AKT protein expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	lysyl oxidase like 2	Homo sapiens	82-87
35218109-13	2022	Additionally, LY294002 treatment caused low KCNQ1OT1 RNA expression and decreased LOXL2 and p-AKT protein expressions.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	AKT serine/threonine kinase 1	Homo sapiens	94-97
35066760-9	2022	Additionally, inhibiting the TLR3 and TLR4 common signaling pathway, PI3K, with LY294002 reduced the inflammatory responses of the poly(I:C)- and LPS-activated microglia and recovered cathepsin X activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	toll-like receptor 3	Mus musculus	29-33
35066760-9	2022	Additionally, inhibiting the TLR3 and TLR4 common signaling pathway, PI3K, with LY294002 reduced the inflammatory responses of the poly(I:C)- and LPS-activated microglia and recovered cathepsin X activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	toll-like receptor 4	Mus musculus	38-42
35066760-9	2022	Additionally, inhibiting the TLR3 and TLR4 common signaling pathway, PI3K, with LY294002 reduced the inflammatory responses of the poly(I:C)- and LPS-activated microglia and recovered cathepsin X activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	80-88	cathepsin Z	Mus musculus	184-195
35242234-10	2022	In addition, the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway inhibitor LY294002 suppressed the migration and invasion of DLD-1 cells by decreasing the expression of YAP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	AKT serine/threonine kinase 1	Homo sapiens	50-53
35242234-10	2022	In addition, the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway inhibitor LY294002 suppressed the migration and invasion of DLD-1 cells by decreasing the expression of YAP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	Yes1 associated transcriptional regulator	Homo sapiens	176-179
35174550-6	2022	Notably, inhibition of PI3K/Akt by LY294002 and HY-10249A lessened the efficacy of maltol.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
35271545-11	2022	The effects of RvE1 were abrogated by blocking phosphatidylinositide3"-kinase (PI3K) and SGK1 with LY294002 and GSK650394, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	47-77
35271545-11	2022	The effects of RvE1 were abrogated by blocking phosphatidylinositide3"-kinase (PI3K) and SGK1 with LY294002 and GSK650394, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	99-107	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	89-93
35354939-9	2022	Ly294002 treatment also decreased these inflammatory indexes in a concentration-dependent manner and blocked inflammatory signals from CCR3, but it did not affect the high expression of CCR3 in AR mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	chemokine (C-C motif) receptor 3	Mus musculus	135-139
35346134-15	2022	Furthermore, selective inhibition of AKT phosphorylation by LY294002 abolished the effect of ZIP12 overexpression on enhancing cell proliferation and migration and partially suppressed the increase in ERK1/2 phosphorylation induced by ZIP12 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	AKT serine/threonine kinase 1	Rattus norvegicus	37-40
35346134-15	2022	Furthermore, selective inhibition of AKT phosphorylation by LY294002 abolished the effect of ZIP12 overexpression on enhancing cell proliferation and migration and partially suppressed the increase in ERK1/2 phosphorylation induced by ZIP12 overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	60-68	mitogen activated protein kinase 3	Rattus norvegicus	201-207
35277194-12	2022	The PI3K/AKT pathway inhibitor, LY294002 could partially attenuate the effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	AKT serine/threonine kinase 1	Homo sapiens	9-12
35344456-0	2022	LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Janus kinase 3	Rattus norvegicus	89-93
35344456-0	2022	LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	120-123
35344456-13	2022	LY294002 decreased the concentration of proinflammatory cytokines INF-gamma, IL-17, IL-6, TNF-alpha, and IL-1beta in aqueous humor and their expression in the ICB and retina of EIU rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 17A	Rattus norvegicus	77-82
35344456-13	2022	LY294002 decreased the concentration of proinflammatory cytokines INF-gamma, IL-17, IL-6, TNF-alpha, and IL-1beta in aqueous humor and their expression in the ICB and retina of EIU rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 6	Rattus norvegicus	84-88
35344456-13	2022	LY294002 decreased the concentration of proinflammatory cytokines INF-gamma, IL-17, IL-6, TNF-alpha, and IL-1beta in aqueous humor and their expression in the ICB and retina of EIU rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	tumor necrosis factor	Rattus norvegicus	90-99
35344456-13	2022	LY294002 decreased the concentration of proinflammatory cytokines INF-gamma, IL-17, IL-6, TNF-alpha, and IL-1beta in aqueous humor and their expression in the ICB and retina of EIU rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	interleukin 1 alpha	Rattus norvegicus	105-113
35344456-14	2022	LY294002 downregulated JAK3 expression in EIU rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	Janus kinase 3	Rattus norvegicus	23-27
35344456-15	2022	LY294002 inhibited p-PI3K and p-Akt expression in EIU rats and restrained Akt translocation from cytoplasm to cell membrane in LPS-treated rMC-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	32-35
35344456-15	2022	LY294002 inhibited p-PI3K and p-Akt expression in EIU rats and restrained Akt translocation from cytoplasm to cell membrane in LPS-treated rMC-1 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
35344456-16	2022	CONCLUSION: LY294002 ameliorates inflammation in EIU by downregulating JAK3 and inactivating the PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	Janus kinase 3	Rattus norvegicus	71-75
35344456-16	2022	CONCLUSION: LY294002 ameliorates inflammation in EIU by downregulating JAK3 and inactivating the PI3K/Akt signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
35387349-6	2022	We added LY294002 to inhibit the PI3K/AKT pathway, and the results indicated that the osteogenic effect of metformin was also blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	AKT serine/threonine kinase 1	Homo sapiens	38-41
35007896-8	2022	The PI3K/Akt pathway inhibitor LY294002 significantly inhibited the proliferation and migration of LPS-induced reactive astrocytes after Ski overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	AKT serine/threonine kinase 1	Homo sapiens	9-12
35007896-8	2022	The PI3K/Akt pathway inhibitor LY294002 significantly inhibited the proliferation and migration of LPS-induced reactive astrocytes after Ski overexpression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	SKI proto-oncogene	Homo sapiens	137-140
35264961-13	2022	In the in vitro experiments, the phosphatidylinositol three kinase (PI3K) inhibitor LY294002 could abrogate the anti-inflammation and antifibrosis therapeutic effects of Cal, demonstrating that the cardioprotective effects of Cal were mediated through upregulations of PI3K and serine/threonine kinase (AKT).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	84-92	AKT serine/threonine kinase 1	Rattus norvegicus	303-306
35281466-11	2022	Chromatin immunoprecipitation assays revealed the interaction between Sp1 and the binding site of proximal ARE on the HO-1 promoter, which was abolished by glutathione, AG1478, Go6976, LY294002, or mithramycin A.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	185-193	heme oxygenase 1	Homo sapiens	118-122
35156537-10	2022	Both NAC and PI3K inhibitor LY294002 could reverse the effects of RPN2 overexpression on the malignant phenotypes of LSCC cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	ribophorin II	Homo sapiens	66-70
35451580-10	2022	Whilst, treatment with 10 muM of special inhibitors, including LY294002 (PI3K) or PD098059 (MAPK), increased Rho 123-associated MFI, treatment with 10 muM of SF1670 (PTEN) almost abolished the effect of miR-205 overexpression (P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-71	microRNA 205	Homo sapiens	203-210
35268655-8	2022	The pretreatment of MEK-ERK pathway inhibitor PD98059 and PI3K/AKT pathway inhibitor LY294002 partially attenuated the protective effect of MTC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	AKT serine/threonine kinase 1	Rattus norvegicus	63-66
35197118-19	2022	The binding of SDF-1 to CXCR4 activated the PI3K/Akt signalling pathway, and LY294002 significantly inhibited hAD-MSC migration induced by SDF-1 in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	C-X-C motif chemokine ligand 12	Rattus norvegicus	15-20
35197118-19	2022	The binding of SDF-1 to CXCR4 activated the PI3K/Akt signalling pathway, and LY294002 significantly inhibited hAD-MSC migration induced by SDF-1 in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	C-X-C motif chemokine receptor 4	Rattus norvegicus	24-29
35197118-19	2022	The binding of SDF-1 to CXCR4 activated the PI3K/Akt signalling pathway, and LY294002 significantly inhibited hAD-MSC migration induced by SDF-1 in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	AKT serine/threonine kinase 1	Rattus norvegicus	49-52
35197118-19	2022	The binding of SDF-1 to CXCR4 activated the PI3K/Akt signalling pathway, and LY294002 significantly inhibited hAD-MSC migration induced by SDF-1 in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	77-85	C-X-C motif chemokine ligand 12	Rattus norvegicus	139-144
35309056-5	2022	In this experiment, a high-glucose (HG)-induced peritoneal fibrosis rat model was successfully established via intraperitoneal injection of HG peritoneal dialysate, and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the mechanistic target of rapamycin (mTOR) inhibitor rapamycin were used to treat peritoneal fibrosis rats.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	173-202
35309056-9	2022	Moreover, LY294002 and rapamycin promoted expression of autophagy-related proteins LC3-II/I, p62, and beclin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	83-91
35309056-9	2022	Moreover, LY294002 and rapamycin promoted expression of autophagy-related proteins LC3-II/I, p62, and beclin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	93-96
35309056-9	2022	Moreover, LY294002 and rapamycin promoted expression of autophagy-related proteins LC3-II/I, p62, and beclin-1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	beclin 1	Rattus norvegicus	102-110
35203062-9	2022	The suppression of ANP secretion by CORM-2 was attenuated by pretreatment with 5-hydroxydecanoic acid, paxilline, and 1H-(1,2,4) oxadiazolo (4,3-a) quinoxalin-1-one, but not by diltiazem, wortmannin, LY-294002, or NG-nitro-L-arginine methyl ester.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-209	natriuretic peptide A	Rattus norvegicus	19-22
35195829-12	2022	Blocking the PI3K/AKT signal pathway by the use of LY294002 eliminated the myocardioprotective effects of lncRNA XR_595552 in H9c2 cells under IH condition.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
35063770-7	2022	The phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 reversed AV-induced increase of BDNF expression, newborn neurons and antidepressant behavior effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	4-33
35063770-7	2022	The phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 reversed AV-induced increase of BDNF expression, newborn neurons and antidepressant behavior effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	51-59	brain derived neurotrophic factor	Mus musculus	92-96
35183219-13	2022	Administration with LY294002 could partially reversed the promotion effects of si-PDX1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	20-28	pancreatic and duodenal homeobox 1	Homo sapiens	82-86
35222803-6	2022	LY294002, the phosphatidylinositol-3-kinase (PI3K)/Akt inhibitor, abolished KGF-2"s effect to some extent, demonstrating that KGF-2 protected HLECs via the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	161-164
35176991-10	2022	In vitro, Fangchinoline and LY294002 inhibited proliferation, induced cell cycle arrest, and promoted apoptosis in Raji and Daudi cells by altering Akt/mTOR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	AKT serine/threonine kinase 1	Homo sapiens	148-151
35176991-10	2022	In vitro, Fangchinoline and LY294002 inhibited proliferation, induced cell cycle arrest, and promoted apoptosis in Raji and Daudi cells by altering Akt/mTOR signaling.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	mechanistic target of rapamycin kinase	Homo sapiens	152-156
35222803-6	2022	LY294002, the phosphatidylinositol-3-kinase (PI3K)/Akt inhibitor, abolished KGF-2"s effect to some extent, demonstrating that KGF-2 protected HLECs via the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	14-43
35165685-8	2022	The reduction in the expression of PI3K/Akt/mTOR was enhanced by the use of the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	thymoma viral proto-oncogene 1	Mus musculus	40-43
35222803-6	2022	LY294002, the phosphatidylinositol-3-kinase (PI3K)/Akt inhibitor, abolished KGF-2"s effect to some extent, demonstrating that KGF-2 protected HLECs via the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	AKT serine/threonine kinase 1	Homo sapiens	51-54
35222803-6	2022	LY294002, the phosphatidylinositol-3-kinase (PI3K)/Akt inhibitor, abolished KGF-2"s effect to some extent, demonstrating that KGF-2 protected HLECs via the PI3K/Akt pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	fibroblast growth factor 10	Homo sapiens	76-81
35169271-5	2022	We showed that preadministration of the PI3K inhibitor LY294002 abolished the repressive effect of ghrelin on CTA memory.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	ghrelin and obestatin prepropeptide	Rattus norvegicus	99-106
35169271-6	2022	Moreover, LY294002 pretreatment prevented ghrelin from inhibiting Arc and zif268 mRNA expression in the BLA triggered by CTA memory retrieval.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	ghrelin and obestatin prepropeptide	Rattus norvegicus	42-49
35169271-6	2022	Moreover, LY294002 pretreatment prevented ghrelin from inhibiting Arc and zif268 mRNA expression in the BLA triggered by CTA memory retrieval.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	nucleolar protein 3	Rattus norvegicus	66-69
35169271-6	2022	Moreover, LY294002 pretreatment prevented ghrelin from inhibiting Arc and zif268 mRNA expression in the BLA triggered by CTA memory retrieval.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	early growth response 1	Rattus norvegicus	74-80
35165685-8	2022	The reduction in the expression of PI3K/Akt/mTOR was enhanced by the use of the PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	mechanistic target of rapamycin kinase	Mus musculus	44-48
35164673-9	2022	In order to bring out the mechanism underlying PI3K/AKT depressing Raf/MEK/ERK, we used PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	AKT serine/threonine kinase 1	Homo sapiens	52-55
35164673-9	2022	In order to bring out the mechanism underlying PI3K/AKT depressing Raf/MEK/ERK, we used PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	zinc fingers and homeoboxes 2	Homo sapiens	67-70
35164673-9	2022	In order to bring out the mechanism underlying PI3K/AKT depressing Raf/MEK/ERK, we used PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	mitogen-activated protein kinase kinase 7	Homo sapiens	71-74
35164673-9	2022	In order to bring out the mechanism underlying PI3K/AKT depressing Raf/MEK/ERK, we used PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	mitogen-activated protein kinase 1	Homo sapiens	75-78
35130910-11	2022	In addition, 24A could up-regulate the expression of phosphorylated phosphoinositide 3-kinases (p-PI3K) and phosphorylated protein kinase B (p-AKT) in GCI/R mice brain, and all the morphological, neurological, and biochemical changes of 24A treatment were abolished by the application of PI3K/AKT pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	315-323	thymoma viral proto-oncogene 1	Mus musculus	143-146
35237277-14	2022	AGN196996, Msr1 siRNA, and LY294002 reversed the therapeutic effects of Am80 by reducing the expression of Msr1 and the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	macrophage scavenger receptor 1	Rattus norvegicus	107-111
35237277-14	2022	AGN196996, Msr1 siRNA, and LY294002 reversed the therapeutic effects of Am80 by reducing the expression of Msr1 and the phosphorylation of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	139-142
35132190-9	2022	Using ERK1/2 inhibitor U0126 and PI3K/AKT inhibitor LY294002, we revealed that the amount of Nurr1 in the nucleus was upregulated through beta-arrestin2/ERK1/2 and PI3K/AKT/GSK-3beta signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	thymoma viral proto-oncogene 1	Mus musculus	38-41
35132190-9	2022	Using ERK1/2 inhibitor U0126 and PI3K/AKT inhibitor LY294002, we revealed that the amount of Nurr1 in the nucleus was upregulated through beta-arrestin2/ERK1/2 and PI3K/AKT/GSK-3beta signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	nuclear receptor subfamily 4, group A, member 2	Mus musculus	93-98
35132190-9	2022	Using ERK1/2 inhibitor U0126 and PI3K/AKT inhibitor LY294002, we revealed that the amount of Nurr1 in the nucleus was upregulated through beta-arrestin2/ERK1/2 and PI3K/AKT/GSK-3beta signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	arrestin, beta 2	Mus musculus	138-152
35132190-9	2022	Using ERK1/2 inhibitor U0126 and PI3K/AKT inhibitor LY294002, we revealed that the amount of Nurr1 in the nucleus was upregulated through beta-arrestin2/ERK1/2 and PI3K/AKT/GSK-3beta signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	mitogen-activated protein kinase 3	Mus musculus	153-159
35132190-9	2022	Using ERK1/2 inhibitor U0126 and PI3K/AKT inhibitor LY294002, we revealed that the amount of Nurr1 in the nucleus was upregulated through beta-arrestin2/ERK1/2 and PI3K/AKT/GSK-3beta signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	thymoma viral proto-oncogene 1	Mus musculus	169-172
35132190-9	2022	Using ERK1/2 inhibitor U0126 and PI3K/AKT inhibitor LY294002, we revealed that the amount of Nurr1 in the nucleus was upregulated through beta-arrestin2/ERK1/2 and PI3K/AKT/GSK-3beta signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	52-60	glycogen synthase kinase 3 alpha	Mus musculus	173-182
35484750-11	2022	The functionality of PI3K/Akt signaling pathway was tested using LY294002, an inhibitor of PI3K.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	65-73	thymoma viral proto-oncogene 1	Mus musculus	26-29
35201262-10	2022	Inhibition of AKT by its inhibitor LY294002 abolishes eHsp90alpha-induced migration and proliferation of corneal epithelial cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-43	thymoma viral proto-oncogene 1	Mus musculus	14-17
35484750-15	2022	However, LY294002 inhibited the shikonin-mediated PI3K/Akt signaling pathway and affected the wound healing process.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	thymoma viral proto-oncogene 1	Mus musculus	55-58
35053144-10	2022	LY294002 infusion revealed the PI3K/Akt involvement in the warm-RIC protection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	thymoma viral proto-oncogene 1	Mus musculus	36-39
34994954-9	2022	Furthermore, addition of LY294002, a selective inhibitor of PI3K (phosphatidylinositol 3 kinase), blocked saikosaponin-D-caused Nrf2 nuclear translocation and reversed the protection of saikosaponin-D against glutamate in SH-SY5Y cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	66-95
34994954-9	2022	Furthermore, addition of LY294002, a selective inhibitor of PI3K (phosphatidylinositol 3 kinase), blocked saikosaponin-D-caused Nrf2 nuclear translocation and reversed the protection of saikosaponin-D against glutamate in SH-SY5Y cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	25-33	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
35387719-13	2022	After the intervention of LY294002, the expression of claudin-5 was significantly decreased as compared with the Xubijing intervention group (claudin-5/beta-actin: 0.41+-0.02 vs. 0.80+-0.08, P < 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	claudin 5	Homo sapiens	54-63
35387719-13	2022	After the intervention of LY294002, the expression of claudin-5 was significantly decreased as compared with the Xubijing intervention group (claudin-5/beta-actin: 0.41+-0.02 vs. 0.80+-0.08, P < 0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	26-34	claudin 5	Homo sapiens	142-151
35053144-11	2022	Infarct size reduction was abrogated by LY294002 pretreatment (warm-RIC: 44 +- 1.13% vs. warm-CTR 58 +- 1.41% p <0.0001; vs. warm-RIC LY 54 +- 1.69% p =0.0002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	40-48	calcitonin receptor	Mus musculus	94-97
35163437-14	2022	Blocking of PI3K signaling by LY294002 inhibited the effect of IGF-1 on GPR17 suppression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	G protein-coupled receptor 17	Homo sapiens	72-77
35069252-0	2021	LY294002 Inhibits Intermediate Conductance Calcium-Activated Potassium (KCa3.1) Current in Human Glioblastoma Cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	potassium calcium-activated channel subfamily N member 4	Homo sapiens	72-78
35111045-6	2021	The results show that L-4F significantly upregulates protein levels of HIF-1alpha, Akt, and ERK, which can be inhibited by the PI3K inhibitor, LY294002, or ERK inhibitor, PD98059, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
35111045-6	2021	The results show that L-4F significantly upregulates protein levels of HIF-1alpha, Akt, and ERK, which can be inhibited by the PI3K inhibitor, LY294002, or ERK inhibitor, PD98059, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	AKT serine/threonine kinase 1	Homo sapiens	83-86
35111045-6	2021	The results show that L-4F significantly upregulates protein levels of HIF-1alpha, Akt, and ERK, which can be inhibited by the PI3K inhibitor, LY294002, or ERK inhibitor, PD98059, respectively.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	mitogen-activated protein kinase 1	Homo sapiens	92-95
35111045-7	2021	Particularly, LY294002 can downregulate the levels of p-ERK, while PD98059 cannot suppress that of p-Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	14-22	mitogen-activated protein kinase 1	Homo sapiens	56-59
35013107-12	2022	In addition, a PI3K inhibitor (LY-294002) and a Nrf2 inhibitor (ML385) observably attenuated the protective effects of MET on MGO-induced apoptosis and ROS generation by inhibiting the Nrf2/HO-1 pathways, while a ROS scavenger (NAC) and a permeability transition pores inhibitor (CsA) completely reversed these effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-40	SAFB like transcription modulator	Homo sapiens	119-122
35013107-12	2022	In addition, a PI3K inhibitor (LY-294002) and a Nrf2 inhibitor (ML385) observably attenuated the protective effects of MET on MGO-induced apoptosis and ROS generation by inhibiting the Nrf2/HO-1 pathways, while a ROS scavenger (NAC) and a permeability transition pores inhibitor (CsA) completely reversed these effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-40	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
35013107-12	2022	In addition, a PI3K inhibitor (LY-294002) and a Nrf2 inhibitor (ML385) observably attenuated the protective effects of MET on MGO-induced apoptosis and ROS generation by inhibiting the Nrf2/HO-1 pathways, while a ROS scavenger (NAC) and a permeability transition pores inhibitor (CsA) completely reversed these effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-40	heme oxygenase 1	Homo sapiens	190-194
35013107-12	2022	In addition, a PI3K inhibitor (LY-294002) and a Nrf2 inhibitor (ML385) observably attenuated the protective effects of MET on MGO-induced apoptosis and ROS generation by inhibiting the Nrf2/HO-1 pathways, while a ROS scavenger (NAC) and a permeability transition pores inhibitor (CsA) completely reversed these effects.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-40	X-linked Kx blood group	Homo sapiens	228-231
35069549-9	2021	These effects of SMS were inhibited when PI3K/Akt activation was blocked by LY294002 in the macrophages.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	thymoma viral proto-oncogene 1	Mus musculus	46-49
35069252-4	2021	By using the electrophysiological approach and noise analysis, we observed that KCa3.1 channel activity is LY294002-sensitive and Wortmannin-resistant in accordance with the involvement of PI3K class IIbeta (PI3KC2beta).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	potassium calcium-activated channel subfamily N member 4	Homo sapiens	80-86
34978009-7	2022	Treatment with CAL101 (PI3K p110delta inhibitor) and LY294002 (PI3Kalpha/delta/beta inhibitor) could inhibit TC movement and differentiation and increase the number of dead TCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-61	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	63-83
35069252-4	2021	By using the electrophysiological approach and noise analysis, we observed that KCa3.1 channel activity is LY294002-sensitive and Wortmannin-resistant in accordance with the involvement of PI3K class IIbeta (PI3KC2beta).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	208-218
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	AKT serine/threonine kinase 1	Homo sapiens	10-13
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	cyclin D1	Homo sapiens	60-69
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	hexokinase 2	Homo sapiens	74-77
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	AKT serine/threonine kinase 1	Homo sapiens	127-130
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	cyclin D1	Homo sapiens	225-234
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	hexokinase 2	Homo sapiens	239-242
34949154-10	2022	We found that overexpression of DHCR24 increased the phosphorylation level of PI3K and AKT, however, the PI3K inhibitor LY294002 (LY) eliminated the protective effect of DHCR24 in ALI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	87-90
35282079-7	2022	Furthermore, both LY294002 (a PI3K inhibitor) and IWR-1 (a Wnt/beta-catenin inhibitor) inhibited the PBMT promotion of NSC proliferation after OGD and suppressed beta-catenin and cyclin D1 expression in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	catenin beta 1	Rattus norvegicus	162-174
35282079-7	2022	Furthermore, both LY294002 (a PI3K inhibitor) and IWR-1 (a Wnt/beta-catenin inhibitor) inhibited the PBMT promotion of NSC proliferation after OGD and suppressed beta-catenin and cyclin D1 expression in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	cyclin D1	Rattus norvegicus	179-188
35282120-12	2022	Moreover, AS downregulated the expression of apoptotic protein, and promoted phosphorylation of PI3K, AKT, and GSK3beta, which was reversed by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	thymoma viral proto-oncogene 1	Mus musculus	102-105
35282120-12	2022	Moreover, AS downregulated the expression of apoptotic protein, and promoted phosphorylation of PI3K, AKT, and GSK3beta, which was reversed by PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	158-166	glycogen synthase kinase 3 alpha	Mus musculus	111-119
34949154-10	2022	We found that overexpression of DHCR24 increased the phosphorylation level of PI3K and AKT, however, the PI3K inhibitor LY294002 (LY) eliminated the protective effect of DHCR24 in ALI.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	24-dehydrocholesterol reductase	Homo sapiens	170-176
35291604-2	2022	Methods: OVCAR3 cancer cells were treated with cisplatin, Ly 294002 (LY), and cisplatin+Ly to investigate the cytotoxicity effect of the mentioned groups via MTT assay.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	58-67	carbonic anhydrase 3	Homo sapiens	9-15
35255737-10	2022	This function of miR-379-5p was exerted through PI3K/Akt pathway and could be blocked by the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	microRNA 379	Homo sapiens	17-24
35255737-10	2022	This function of miR-379-5p was exerted through PI3K/Akt pathway and could be blocked by the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	53-56
35255737-10	2022	This function of miR-379-5p was exerted through PI3K/Akt pathway and could be blocked by the PI3K/Akt pathway inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	AKT serine/threonine kinase 1	Homo sapiens	98-101
35100937-7	2022	Both the JNK inhibitor (SP600125) and p38 inhibitor (SB203580) reversed the phosphorylation of STAT3, and the ERK inhibitor (FR180204) and AKT inhibitor (LY294002) reduced the expression of STAT3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	mitogen-activated protein kinase 1	Homo sapiens	110-113
35100937-7	2022	Both the JNK inhibitor (SP600125) and p38 inhibitor (SB203580) reversed the phosphorylation of STAT3, and the ERK inhibitor (FR180204) and AKT inhibitor (LY294002) reduced the expression of STAT3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	154-162	signal transducer and activator of transcription 3	Homo sapiens	190-195
35475577-10	2022	Immunofluorescence analysis revealed that PDGF-BB enhanced the accumulation of FOXO4 in the VSMCs, while the treatment of atorvastatin was able to attenuate this effect and the co-treatment of Akt inhibitor LY294002 could further inhibit the phenotype.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	forkhead box O4	Rattus norvegicus	79-84
35475577-10	2022	Immunofluorescence analysis revealed that PDGF-BB enhanced the accumulation of FOXO4 in the VSMCs, while the treatment of atorvastatin was able to attenuate this effect and the co-treatment of Akt inhibitor LY294002 could further inhibit the phenotype.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	207-215	AKT serine/threonine kinase 1	Rattus norvegicus	193-196
35475577-11	2022	The treatment of PDGF-BB enhanced the interaction of SRF with FOXO4 and myocardin in the VSMCs, in which the co-treatment of atorvastatin and LY294002 could reverse the effect of PDGF-BB in the system.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	serum response factor	Rattus norvegicus	53-56
35475577-11	2022	The treatment of PDGF-BB enhanced the interaction of SRF with FOXO4 and myocardin in the VSMCs, in which the co-treatment of atorvastatin and LY294002 could reverse the effect of PDGF-BB in the system.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	142-150	forkhead box O4	Rattus norvegicus	62-67
35355710-9	2022	Moreover, the PI3K/AKT and Wnt/beta-catenin signaling inhibitors, LY294002 and XAV-939, ameliorated BLM-meditated PF in vivo and relieved EMT in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	thymoma viral proto-oncogene 1	Mus musculus	19-22
35355710-9	2022	Moreover, the PI3K/AKT and Wnt/beta-catenin signaling inhibitors, LY294002 and XAV-939, ameliorated BLM-meditated PF in vivo and relieved EMT in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	66-74	catenin (cadherin associated protein), beta 1	Mus musculus	31-43