PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25433991-4 2014 Mechanism studies revealed that Cd(II) affected the transformations of intracellular PHAs and glycogen, and the activities of oxidoreductase and polyphosphate kinase, resulted in the decrease of nitrite oxidizing bacteria and polyphosphate accumulating organisms abundance, which might be the major reason for the negative effects of long-term exposure to 10 mg L(-1) Cd(II) on biological nitrogen and phosphorus removal. Nitrites 195-202 thioredoxin reductase 1 Homo sapiens 126-140 25351391-2 2014 This method which is simple, inexpensive and effective in the removal of nitrite is greatly selective for NO2(-) and was used for mixed samples containing both NO2(-) and NO3(-) with little or no measurable cross-contamination. Nitrites 73-80 NBL1, DAN family BMP antagonist Homo sapiens 171-174 25243423-7 2014 Furthermore, HSC70 decreased LPS-induced elevation of circulating tumor necrosis factor alpha and nitrite/nitrate, and tissue expression of inducible nitric oxide synthase, cyclooxygenase 2, and matrix metalloproteinase 9 in the heart and liver. Nitrites 98-105 heat shock protein family A (Hsp70) member 8 Rattus norvegicus 13-18 25239655-2 2014 NOS3 and NOS2 SNPs might modify plasma nitrite/nitrate (NOx) levels, sepsis development, hemodynamics and survival. Nitrites 39-46 nitric oxide synthase 3 Homo sapiens 0-4 24942042-6 2014 The difference in methemoglobin formation after nitrite administration between fresh and aged RBCs was only present under deoxygenated conditions and not under oxygenated conditions. Nitrites 48-55 hemoglobin subunit gamma 2 Homo sapiens 18-31 25505423-6 2014 Nitrite/nitrate decreased from 23 (18-27) muM at baseline to 19 (14-24) muM and 18 (14-21) muM in hypoxia and recovery, respectively (p < 0.05). Nitrites 0-7 latexin Homo sapiens 42-45 25505423-6 2014 Nitrite/nitrate decreased from 23 (18-27) muM at baseline to 19 (14-24) muM and 18 (14-21) muM in hypoxia and recovery, respectively (p < 0.05). Nitrites 0-7 latexin Homo sapiens 72-75 25505423-6 2014 Nitrite/nitrate decreased from 23 (18-27) muM at baseline to 19 (14-24) muM and 18 (14-21) muM in hypoxia and recovery, respectively (p < 0.05). Nitrites 0-7 latexin Homo sapiens 72-75 25239655-2 2014 NOS3 and NOS2 SNPs might modify plasma nitrite/nitrate (NOx) levels, sepsis development, hemodynamics and survival. Nitrites 39-46 nitric oxide synthase 2 Homo sapiens 9-13 25280017-3 2014 Because the N2 selectivity is determined at the nitrite (NO2-) reduction step on the Pd surface, which occurs after NO3- is decomposed into NO2- on the secondary metallic catalyst, we here performed density functional theory (DFT) calculations and experiments to investigate the NO2- reduction pathway on the Pd surface activated by hydrogen. Nitrites 48-55 NBL1, DAN family BMP antagonist Homo sapiens 116-119 25310225-11 2014 Acetylcholine also increased the nitrate/nitrite concentration in TRPC3 WT mice, but not in KO mice. Nitrites 41-48 transient receptor potential cation channel, subfamily C, member 3 Mus musculus 66-71 25163536-10 2014 The absence of eNOS leads to enhanced plasma nitrite levels following nitrate administration in vivo, which negatively impacts on platelet function. Nitrites 45-52 nitric oxide synthase 3 Homo sapiens 15-19 25443415-2 2014 [9] that neutrophil preparations from a patient with tyrosinemia type III, i.e. with inherited deficiency of 4-hydroxyphenylpyruvate dioxygenase (HPPD), exhibited a far higher NO release than controls, when NO was estimated in terms of nitrite content in the suspending media. Nitrites 236-243 4-hydroxyphenylpyruvate dioxygenase Homo sapiens 109-144 25443415-2 2014 [9] that neutrophil preparations from a patient with tyrosinemia type III, i.e. with inherited deficiency of 4-hydroxyphenylpyruvate dioxygenase (HPPD), exhibited a far higher NO release than controls, when NO was estimated in terms of nitrite content in the suspending media. Nitrites 236-243 4-hydroxyphenylpyruvate dioxygenase Homo sapiens 146-150 25443415-6 2014 Moreover, we found that 500muM l-tyrosine increases nitrite release and accumulation in suspending media of U-937 cells, a human monoblast-like lymphoma cell line which displays many characteristics of macrophages, including the expression of inducible and endothelial nitric oxide synthases. Nitrites 52-59 latexin Homo sapiens 27-30 25115547-0 2014 Homocysteine and nitrite levels are modulated by MTHFR 677C>T polymorphism in obese women treated with simvastatin. Nitrites 17-24 methylenetetrahydrofolate reductase Homo sapiens 49-54 25186490-9 2014 In addition, alpha2A/alpha2C-adrenoceptor depletion enhanced the levels of nitrite and hydroxyproline, and the protein expression of transforming growth factor-beta and vascular endothelial growth factor. Nitrites 75-82 adrenergic receptor, alpha 2a Mus musculus 13-20 25042033-8 2014 Comparatively stronger associations were observed between nitrite, eosinophil cationic protein, leukotrienes C/D/E4 and interleukin-8 in sputum. Nitrites 58-65 C-X-C motif chemokine ligand 8 Homo sapiens 120-133 25186490-9 2014 In addition, alpha2A/alpha2C-adrenoceptor depletion enhanced the levels of nitrite and hydroxyproline, and the protein expression of transforming growth factor-beta and vascular endothelial growth factor. Nitrites 75-82 adrenergic receptor, alpha 2c Mus musculus 21-41 25173937-0 2014 Nitrate (NO3(-)) and nitrite (NO2(-)) are endocrine disruptors to downregulate expression of tyrosine hydroxylase and motor behavior through conversion to nitric oxide in early development of zebrafish. Nitrites 21-28 tyrosine hydroxylase Danio rerio 93-113 25059171-8 2014 In addition, the feasibility of the method was demonstrated with extraction and determination of nitrite from some real samples containing tap, mineral, sea, rain, snow and ground waters, with the recovery in standard addition to real matrix of 94-102 % and RSDs of 1.8-10.6%. Nitrites 97-104 nuclear RNA export factor 1 Homo sapiens 139-142 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrites 181-188 estrogen receptor 1 Danio rerio 69-86 25249806-5 2014 Infants with congenital enzyme deficiencies in glucose-6-phosphate dehydrogenase and methemoglobin reductase are at greater risk of nitrite-induced methemoglobinemia from nitrates in water and food and from exposures to hemoglobin oxidizers. Nitrites 132-139 glucose-6-phosphate dehydrogenase Homo sapiens 47-80 25249806-5 2014 Infants with congenital enzyme deficiencies in glucose-6-phosphate dehydrogenase and methemoglobin reductase are at greater risk of nitrite-induced methemoglobinemia from nitrates in water and food and from exposures to hemoglobin oxidizers. Nitrites 132-139 hemoglobin subunit gamma 2 Homo sapiens 85-98 25173937-2 2014 Both nitrate and nitrite exposure decreased the expression of tyrosine hydroxylase (TH) in dopaminergic neurons at 48hpf. Nitrites 17-24 tyrosine hydroxylase Danio rerio 62-82 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrites 181-188 estrogen receptor 1 Danio rerio 277-294 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrites 181-188 estrogen receptor 1 Danio rerio 296-298 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrites 44-51 estrogen receptor 1 Danio rerio 69-86 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrites 44-51 estrogen receptor 1 Danio rerio 277-294 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrites 44-51 estrogen receptor 1 Danio rerio 296-298 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrites 181-188 estrogen receptor 1 Danio rerio 69-86 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrites 181-188 estrogen receptor 1 Danio rerio 277-294 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrites 181-188 estrogen receptor 1 Danio rerio 296-298 25015965-7 2014 While HDAC1 knockdown with small-interfering RNA resulted in no change in NOS3 acetylation level, yet increased basal nitrite production (730.6 +- 99.1 pmol mg(-1) h(-1)) and further exaggerated increases in endothelin-1 stimulated nitrite production (1276.9 +- 288.2 pmol mg(-1) h(-1)) was observed. Nitrites 118-125 histone deacetylase 1 Bos taurus 6-11 25015965-7 2014 While HDAC1 knockdown with small-interfering RNA resulted in no change in NOS3 acetylation level, yet increased basal nitrite production (730.6 +- 99.1 pmol mg(-1) h(-1)) and further exaggerated increases in endothelin-1 stimulated nitrite production (1276.9 +- 288.2 pmol mg(-1) h(-1)) was observed. Nitrites 232-239 histone deacetylase 1 Bos taurus 6-11 23894175-5 2014 Nitrite concentrations averaged 0.07 +- 0.01 muM in milk of mothers of preterm infants, less than that of term infants (0.13 +- 0.02 muM) (P < .01). Nitrites 0-7 latexin Homo sapiens 45-48 24924950-5 2014 Moreover, myeloperoxidase (MPO) as a likely alternative mechanism for nitrative modification of alpha-enolase in vivo was apparently facilitated by the presence of higher MPO level and activity in diabetic liver, and fact that Tyr 12 and Tyr 191 of enolase was nitrated by MPO/nitrite/H2O2 system in vitro. Nitrites 277-284 myeloperoxidase Rattus norvegicus 10-25 24924950-5 2014 Moreover, myeloperoxidase (MPO) as a likely alternative mechanism for nitrative modification of alpha-enolase in vivo was apparently facilitated by the presence of higher MPO level and activity in diabetic liver, and fact that Tyr 12 and Tyr 191 of enolase was nitrated by MPO/nitrite/H2O2 system in vitro. Nitrites 277-284 myeloperoxidase Rattus norvegicus 27-30 24924950-5 2014 Moreover, myeloperoxidase (MPO) as a likely alternative mechanism for nitrative modification of alpha-enolase in vivo was apparently facilitated by the presence of higher MPO level and activity in diabetic liver, and fact that Tyr 12 and Tyr 191 of enolase was nitrated by MPO/nitrite/H2O2 system in vitro. Nitrites 277-284 enolase 1 Rattus norvegicus 96-109 25414768-10 2014 Transfection of siRNA targeting HO-1 reversed TI-I-174-mediated inhibition of nitrite production. Nitrites 78-85 heme oxygenase 1 Mus musculus 32-36 24914193-7 2014 The ET-1+endothelin receptor type-A antagonist BQ-123 and the ETBR agonists sarafotoxin 6c and IRL-1620 caused less vasorelaxation and nitrate/nitrite production in RUPP than in Norm-Preg. Nitrites 143-150 endothelin 1 Rattus norvegicus 4-8 24914193-7 2014 The ET-1+endothelin receptor type-A antagonist BQ-123 and the ETBR agonists sarafotoxin 6c and IRL-1620 caused less vasorelaxation and nitrate/nitrite production in RUPP than in Norm-Preg. Nitrites 143-150 endothelin receptor type B Rattus norvegicus 62-66 24809976-9 2014 Exhaled breath condensate nitrite correlated with plateau pressure (r = 0.27, P = 0.042) and plasma neutrophil elastase (r = 0.44, P = 0.001). Nitrites 26-33 elastase, neutrophil expressed Homo sapiens 100-119 25148388-5 2014 Questions remain relating to the precise concentration of nitrite and the exact dose-response relations between nitrite and myoglobin under hypoxia. Nitrites 112-119 myoglobin Mus musculus 124-133 24518246-4 2014 We found that IL-13 and IFN-gamma synergistically enhanced iNOS, nitrite, and 3NT, corresponding with increased H(2)O(2). Nitrites 65-72 interleukin 13 Homo sapiens 14-19 24518246-4 2014 We found that IL-13 and IFN-gamma synergistically enhanced iNOS, nitrite, and 3NT, corresponding with increased H(2)O(2). Nitrites 65-72 interferon gamma Homo sapiens 24-33 24862953-2 2014 AOB use (i) ammonia monooxygenase for biological ammonia (NH3) oxidation to hydroxylamine (NH2OH) and (ii) hydroxylamine oxidoreductase for NH2OH oxidation to nitrite. Nitrites 159-166 thioredoxin reductase 1 Homo sapiens 121-135 25033468-12 2014 By means of this UPLC-MS/MS (15)N-citrulline assay, N(G)-nitro-arginine (100 muM) was found to inhibit recombinant inducible NOS (iNOS) activity (by 38%), whereas nitrite and GSSG (each at 500 muM) did not affect iNOS activity at all. Nitrites 163-170 nitric oxide synthase 2 Homo sapiens 115-128 25033468-12 2014 By means of this UPLC-MS/MS (15)N-citrulline assay, N(G)-nitro-arginine (100 muM) was found to inhibit recombinant inducible NOS (iNOS) activity (by 38%), whereas nitrite and GSSG (each at 500 muM) did not affect iNOS activity at all. Nitrites 163-170 nitric oxide synthase 2 Homo sapiens 130-134 25005793-9 2014 Neutrophil nitrite levels as indicative of inducible nitric oxide synthase (iNOS) activity progressively increased after diving and recovery. Nitrites 11-18 nitric oxide synthase 2 Homo sapiens 43-74 25005793-9 2014 Neutrophil nitrite levels as indicative of inducible nitric oxide synthase (iNOS) activity progressively increased after diving and recovery. Nitrites 11-18 nitric oxide synthase 2 Homo sapiens 76-80 24858214-2 2014 We have recently shown that nitrite ions in the presence of erythrocytes inhibit platelet aggregation and activation, as measured by aggregometry and flow cytometric analysis of P-selectin, through its reduction to NO under partially deoxygenated conditions. Nitrites 28-35 selectin P Homo sapiens 178-188 25148388-10 2014 Given that myoglobin significantly contributes to nitrite reduction under hypoxia, dose-response experiments using physiological to pharmacological nitrite concentrations were conducted. Nitrites 50-57 myoglobin Mus musculus 11-20 25148388-15 2014 This requires the presence of vascular myoglobin for both physiological and pharmacological nitrite levels. Nitrites 92-99 myoglobin Mus musculus 39-48 24829498-7 2014 NOS1 protein expression, however, significantly increased with HS only in SHR, and this corresponded to an increase in urinary nitrate/nitrite excretion. Nitrites 135-142 nitric oxide synthase 1 Rattus norvegicus 0-4 25001619-4 2014 Under optimal conditions, the limits of detection and quantification for nitrite are 1.0 and 7.8 muM, respectively, while the corresponding values for nitrate are 19 and 48 muM, respectively. Nitrites 73-80 latexin Homo sapiens 97-100 24791832-1 2014 Although interest in biomarkers in the nitrate-nitrite-NO pathway has recently increased, associations between nitrite (NO2(-)) and nitrate (NO3(-)), and asthma, allergic sensitisation and rhinitis remain unclear. Nitrites 111-118 NBL1, DAN family BMP antagonist Homo sapiens 141-144 24771067-8 2014 CYP2E1 inhibitor, DAS noticeably alleviated maneb- and paraquat-induced ROS, LPO, 4-HNE, SOD, Nrf2 and HO-1, GST, GSH, and GST-pi while iNOS, nitrite content and GSTA4-4 levels were unchanged. Nitrites 142-149 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 0-6 24905176-3 2014 The most promising scaffold exhibits a stable diazonium intermediate, proceeds in a high yield, and gels nitrite-spiked tap, river, and pond water. Nitrites 105-112 nuclear RNA export factor 1 Homo sapiens 120-123 27379296-0 2014 Nitrite as Direct S-Nitrosylating Agent of Kir2.1 Channels. Nitrites 0-7 potassium inwardly-rectifying channel, subfamily J, member 2 Rattus norvegicus 43-49 27379296-8 2014 Our results suggest, for the first time, that nitrite represents a direct S-nitrosylating agent in cardiac tissues and that inward-rectifier potassium ion channels (Kir2.1) are one of the targets. Nitrites 46-53 potassium inwardly-rectifying channel, subfamily J, member 2 Rattus norvegicus 165-171 24678970-6 2014 We determined the role of adenosine A2B receptor in mediating VEGF overproduction and nitrite in diabetic nephropathy. Nitrites 86-93 adenosine A2b receptor Homo sapiens 26-48 25071800-2 2014 A central reaction in the cycle involves the reduction of nitrate (NO(-) 3) to nitrite (NO(-) 2) catalyzed by nitrate reductase (NR). Nitrites 79-86 nitrate reductase 1 Arabidopsis thaliana 110-127 24742815-7 2014 Inhibition of neutral SMase (N-SMase) activity via GW 4869 treatment caused a significant reduction in nuclear translocation of NF-kappaB, NOS2 expression, nitrite/nitrate levels, nitrotyrosine formation, and apoptosis in ER-stressed RPE cells. Nitrites 156-163 sphingomyelin phosphodiesterase 2 Homo sapiens 22-27 24742815-7 2014 Inhibition of neutral SMase (N-SMase) activity via GW 4869 treatment caused a significant reduction in nuclear translocation of NF-kappaB, NOS2 expression, nitrite/nitrate levels, nitrotyrosine formation, and apoptosis in ER-stressed RPE cells. Nitrites 156-163 sphingomyelin phosphodiesterase 2 Homo sapiens 29-36 23946270-3 2014 In vitro, active ingredient-containing CS3/PCLNM is effective in inhibiting the formation of nitrite and the growth of Staphylococcus aureus. Nitrites 93-100 calsyntenin 3 Mus musculus 39-42 25015447-6 2014 Although both leaf extracts decreased the concentration of TBARS, H2O2 and nitrite contents which enhance due to CCl4 toxicity but effect was higher in ethanolic extract. Nitrites 75-82 C-C motif chemokine ligand 4 Rattus norvegicus 113-117 24904028-3 2014 The product of AT5G62720 was localized to the chloroplast envelope membrane and was shown to confer nitrite uptake activity on the NA4 mutant when expressed with an N-terminally truncated transit peptide or as a fusion with the N-terminal region of the cyanobacterial HPP family protein. Nitrites 100-107 Integral membrane HPP family protein Arabidopsis thaliana 15-24 24904028-5 2014 Illuminated chloroplasts isolated from the mutant lines of AT5G62720 showed much lower activity of nitrite uptake than the chloroplasts isolated from the wild-type Col-0 plants, while the chloroplasts of the mutants of AT1G68570 (AtNPF3.1), the gene previously reported to encode a plastid nitrite transporter AtNitr1, showed wild-type levels of nitrite uptake activity. Nitrites 99-106 Integral membrane HPP family protein Arabidopsis thaliana 59-68 24904028-5 2014 Illuminated chloroplasts isolated from the mutant lines of AT5G62720 showed much lower activity of nitrite uptake than the chloroplasts isolated from the wild-type Col-0 plants, while the chloroplasts of the mutants of AT1G68570 (AtNPF3.1), the gene previously reported to encode a plastid nitrite transporter AtNitr1, showed wild-type levels of nitrite uptake activity. Nitrites 99-106 Major facilitator superfamily protein Arabidopsis thaliana 219-228 24904028-5 2014 Illuminated chloroplasts isolated from the mutant lines of AT5G62720 showed much lower activity of nitrite uptake than the chloroplasts isolated from the wild-type Col-0 plants, while the chloroplasts of the mutants of AT1G68570 (AtNPF3.1), the gene previously reported to encode a plastid nitrite transporter AtNitr1, showed wild-type levels of nitrite uptake activity. Nitrites 290-297 Integral membrane HPP family protein Arabidopsis thaliana 59-68 24904028-7 2014 It has a putative transit peptide similar to that of AT5G62720 and its fusion with the N-terminal region of the cyanobacterial HPP protein showed low but significant activity of nitrite transport in the cyanobacterial cell. Nitrites 178-185 Integral membrane HPP family protein Arabidopsis thaliana 53-62 25006970-2 2014 N-removal over nitrite requires less COD, which is particularly interesting if COD is the limiting parameter for nutrient removal. Nitrites 15-22 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 37-40 25006970-2 2014 N-removal over nitrite requires less COD, which is particularly interesting if COD is the limiting parameter for nutrient removal. Nitrites 15-22 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 79-82 24978825-0 2014 Fat content and nitrite-curing influence the formation of oxidation products and NOC-specific DNA adducts during in vitro digestion of meat. Nitrites 16-23 nocturnin Homo sapiens 81-84 24904028-8 2014 Transcription of AT5G62720 (AtNITR2;1) and AT3G47980 (AtNITR2;2) was stimulated by nitrate under the control of the NIN-like proteins, suggesting that the HPP proteins represent nitrate-inducible components of the nitrite transport system of plastids. Nitrites 214-221 Integral membrane HPP family protein Arabidopsis thaliana 17-26 24904028-8 2014 Transcription of AT5G62720 (AtNITR2;1) and AT3G47980 (AtNITR2;2) was stimulated by nitrate under the control of the NIN-like proteins, suggesting that the HPP proteins represent nitrate-inducible components of the nitrite transport system of plastids. Nitrites 214-221 Integral membrane HPP family protein Arabidopsis thaliana 43-52 24843165-6 2014 sEH was inhibited in WT mice fed linoleic acid and nitrite, key constituents of the Mediterranean diet that elevates electrophilic nitro fatty acid levels, whereas KIs were unaffected. Nitrites 51-58 epoxide hydrolase 2, cytoplasmic Mus musculus 0-3 24748593-2 2014 The present study was designed to evaluate the relationship between exercise training and NOS3 polymorphisms at -786T>C, 894G>T, and intron 4b/a on blood pressure (BP) using 24-h ambulatory BP monitoring (ABPM), nitrate/nitrite levels (NOx), and redox state. Nitrites 226-233 nitric oxide synthase 3 Homo sapiens 90-94 24430198-3 2014 The cytochrome c oxidase binuclear heme a 3/CuB active site is one entity known to be responsible for conversion of cellular nitrite to nitric oxide. Nitrites 125-132 cytochrome c, somatic Homo sapiens 4-16 24663342-6 2014 Treatment of mEL5 with nitrate or nitrite caused meristematic cell death accompanied by browning. Nitrites 34-41 epilepsy 5 Mus musculus 13-17 24663342-9 2014 More superoxide was detected in mEL5 roots after treatment with nitrite or cytokinin, and treatment with an inhibitor of superoxide production prevented mEL5 roots from both nitrite- and cytokinin-induced meristematic cell death. Nitrites 64-71 epilepsy 5 Mus musculus 32-36 24663342-9 2014 More superoxide was detected in mEL5 roots after treatment with nitrite or cytokinin, and treatment with an inhibitor of superoxide production prevented mEL5 roots from both nitrite- and cytokinin-induced meristematic cell death. Nitrites 174-181 epilepsy 5 Mus musculus 153-157 24658348-9 2014 The inhibition of xanthine oxidoreductase by oxypurinol attenuated the acute hypotensive effects of nitrite. Nitrites 100-107 xanthine dehydrogenase Rattus norvegicus 18-41 24599317-7 2014 Treatments increasing nitrite production also increased iNOS expression, while treatments decreasing nitrite production reduced iNOS expression. Nitrites 101-108 nitric oxide synthase 2, inducible Mus musculus 128-132 24599317-8 2014 Among the different NOS isoforms, experiments using L-748,337 or BRL37344 with activators or inhibitors targeting specific NOS isoforms demonstrated a prominent role of iNOS in nitrite production. Nitrites 177-184 nitric oxide synthase 2, inducible Mus musculus 169-173 24599317-5 2014 beta3-AR blockade with L-748,337 reduced basal nitrite production, while beta3-AR stimulation with BRL37344 increased it. Nitrites 47-54 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 0-5 24658348-10 2014 Taken together, our results show that nitrite exerts antihypertensive effects in L-NAME hypertensive rats and provide evidence that xanthine oxidoreductase plays an important role in this antihypertensive effect. Nitrites 38-45 xanthine dehydrogenase Rattus norvegicus 132-155 24599317-5 2014 beta3-AR blockade with L-748,337 reduced basal nitrite production, while beta3-AR stimulation with BRL37344 increased it. Nitrites 47-54 adrenergic receptor, beta 3 Mus musculus 0-8 24599317-7 2014 Treatments increasing nitrite production also increased iNOS expression, while treatments decreasing nitrite production reduced iNOS expression. Nitrites 22-29 nitric oxide synthase 2, inducible Mus musculus 56-60 24512212-7 2014 Inhibition of iNOS via administration of 1400W ameliorated renal injury and decreased tissue lipid peroxidation (malondialdehyde), superoxide dismutase, glutathione peroxidase and nitrite/nitrate levels (NOx). Nitrites 180-187 nitric oxide synthase 2 Rattus norvegicus 14-18 24703968-6 2014 A significant improvement of spatial memory was evident in the Abeta(25-35)-treated group at day 30 post-injection subjected to AG treatment; this effect was correlated with decreases in reactive gliosis, IL-1beta, TNF-alpha, and nitrite levels, as well as a reduction in neurodegeneration in the TCx and hippocampus (Hp). Nitrites 230-237 amyloid beta precursor protein Rattus norvegicus 63-68 24356583-1 2014 The APEX software predicts the photochemical transformation kinetics of xenobiotics in surface waters as a function of: photoreactivity parameters (direct photolysis quantum yield and second-order reaction rate constants with transient species, namely OH, CO3(-) , (1)O2 and the triplet states of chromophoric dissolved organic matter, (3)CDOM*), water chemistry (nitrate, nitrite, bicarbonate, carbonate, bromide and dissolved organic carbon, DOC), and water depth (more specifically, the optical path length of sunlight in water). Nitrites 374-381 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 4-8 24613657-7 2014 The EC50 for inhibition of induced IL-1beta production by the cells was estimated to be 10-12microg/ml (about 36microM) and corresponded to the production of around 30microM nitrites in the culture medium. Nitrites 174-182 interleukin 1 beta Homo sapiens 35-43 24556414-8 2014 Specifically, nitrite promotes mitochondrial fusion by increasing the profusion protein mitofusin 1 while concomitantly activating protein kinase A (PKA), which phosphorylates and inhibits the profission protein dynamin-related protein 1 (Drp1). Nitrites 14-21 mitofusin 1 Mus musculus 88-99 24556414-8 2014 Specifically, nitrite promotes mitochondrial fusion by increasing the profusion protein mitofusin 1 while concomitantly activating protein kinase A (PKA), which phosphorylates and inhibits the profission protein dynamin-related protein 1 (Drp1). Nitrites 14-21 dynamin 1-like Mus musculus 212-237 24556414-8 2014 Specifically, nitrite promotes mitochondrial fusion by increasing the profusion protein mitofusin 1 while concomitantly activating protein kinase A (PKA), which phosphorylates and inhibits the profission protein dynamin-related protein 1 (Drp1). Nitrites 14-21 dynamin 1-like Mus musculus 239-243 24556414-10 2014 Importantly, inhibition of PKA or Drp1 significantly attenuates nitrite-induced mitochondrial respiration and glucose uptake. Nitrites 64-71 dynamin 1-like Mus musculus 34-38 24500710-2 2014 Both human isoforms mARC-1 and mARC-2 are able to catalyze the reduction of nitrite when they are in the reduced form. Nitrites 76-83 mitochondrial amidoxime reducing component 2 Mus musculus 20-26 24500710-2 2014 Both human isoforms mARC-1 and mARC-2 are able to catalyze the reduction of nitrite when they are in the reduced form. Nitrites 76-83 mitochondrial amidoxime reducing component 2 Mus musculus 31-37 24500710-5 2014 To determine if nitrite reduction is catalyzed by molybdenum in the active site of mARC-1, we mutated the putative active site cysteine residue (Cys-273), known to coordinate molybdenum binding. Nitrites 16-23 mitochondrial amidoxime reducing component 2 Mus musculus 83-89 24500710-8 2014 Therefore, we conclude that human mARC-1 and mARC-2 are capable of catalyzing reduction of nitrite to NO through reaction with its molybdenum cofactor. Nitrites 91-98 mitochondrial amidoxime reducing component 2 Mus musculus 34-40 24500710-8 2014 Therefore, we conclude that human mARC-1 and mARC-2 are capable of catalyzing reduction of nitrite to NO through reaction with its molybdenum cofactor. Nitrites 91-98 mitochondrial amidoxime reducing component 2 Mus musculus 45-51 24500710-9 2014 Finally, expression of mARC-1 in HEK cells using a lentivirus vector was used to confirm cellular nitrite reduction to NO. Nitrites 98-105 mitochondrial amidoxime reducing component 2 Mus musculus 23-29 24617811-1 2014 This study demonstrates that the production of reactive oxidizing species (e.g., hydroxyl radical ( OH)) during the photolysis of nitrite (NO2(-)) or nitrate (NO3(-)) leads to the oxidative conversion of arsenite (As(III)) to arsenate (As(V)). Nitrites 130-137 NBL1, DAN family BMP antagonist Homo sapiens 159-162 24113841-8 2014 Eight weeks after diabetes induction, we observed increased numbers of GFAP(+) astrocytes immunostaining associated with increased lipid peroxidation, decreased superoxide dismutase activity, and elevated nitrite levels in the hippocampus of STZ-diabetic rats. Nitrites 205-212 glial fibrillary acidic protein Rattus norvegicus 71-75 24447953-5 2014 Nitrite levels were enhanced by pretreatment with deltaV1-1 30 minutes before ACA possibly attributable to enhanced endothelial NOS protein levels. Nitrites 0-7 nitric oxide synthase 3 Homo sapiens 116-131 24645669-10 2014 TUDCA treatment reduced the production of nitrites by microglial cells and astrocytes induced by proinflammatory stimuli that led to transcriptional and translational diminution of the iNOS. Nitrites 42-50 nitric oxide synthase 2, inducible Mus musculus 185-189 24374966-8 2014 Finally, inhibition of HDAC1, -2, and -3 decreased LPS-induced expression of TNF-alpha, IL-1beta, iNOS (NOS2), and nitrite synthesis. Nitrites 115-122 histone deacetylase 1 Mus musculus 23-40 24642865-2 2014 We recently showed that the addition of nitrite to platelet-rich plasma in the presence of erythrocytes could inhibit platelet aggregation and this inhibitory effect of nitrite + erythrocytes was enhanced by deoxygenation of erythrocytes as measured by P-selectin expression and cGMP production. Nitrites 40-47 selectin P Homo sapiens 253-263 24658539-9 2014 Consistently, excessive nitrite diminished expressions of valve progenitor markers including bmp4, has2, vcana and notch1b at 48 hpf. Nitrites 24-31 bone morphogenetic protein 4 Danio rerio 93-97 24658539-9 2014 Consistently, excessive nitrite diminished expressions of valve progenitor markers including bmp4, has2, vcana and notch1b at 48 hpf. Nitrites 24-31 hyaluronan synthase 2 Danio rerio 99-103 24658539-9 2014 Consistently, excessive nitrite diminished expressions of valve progenitor markers including bmp4, has2, vcana and notch1b at 48 hpf. Nitrites 24-31 versican a Danio rerio 105-110 24658539-9 2014 Consistently, excessive nitrite diminished expressions of valve progenitor markers including bmp4, has2, vcana and notch1b at 48 hpf. Nitrites 24-31 notch receptor 1b Danio rerio 115-122 24211453-0 2014 Direct electrochemistry of myoglobin at reduced graphene oxide-multiwalled carbon nanotubes-platinum nanoparticles nanocomposite and biosensing towards hydrogen peroxide and nitrite. Nitrites 174-181 myoglobin Homo sapiens 27-36 24211453-1 2014 We described the preparation of a novel nanobiocomposite, reduced graphene oxide- multiwalled carbon nanotubes-platinum nanoparticles/myoglobin (RGO-MWCNT-Pt/Mb) for the direct electrochemistry of myoglobin and its application towards determination of hydrogen peroxide (H2O2) and nitrite (NO2(-)). Nitrites 281-288 myoglobin Homo sapiens 134-143 24211453-1 2014 We described the preparation of a novel nanobiocomposite, reduced graphene oxide- multiwalled carbon nanotubes-platinum nanoparticles/myoglobin (RGO-MWCNT-Pt/Mb) for the direct electrochemistry of myoglobin and its application towards determination of hydrogen peroxide (H2O2) and nitrite (NO2(-)). Nitrites 281-288 myoglobin Homo sapiens 197-206 24642865-2 2014 We recently showed that the addition of nitrite to platelet-rich plasma in the presence of erythrocytes could inhibit platelet aggregation and this inhibitory effect of nitrite + erythrocytes was enhanced by deoxygenation of erythrocytes as measured by P-selectin expression and cGMP production. Nitrites 169-176 selectin P Homo sapiens 253-263 24642865-5 2014 Nitrite (0.1 to 1.0 muM) significantly decreased the percentage of these surface markers on the platelet membrane at the hematocrit values above 23% and oxygen levels lower than 49 mmHg. Nitrites 0-7 latexin Homo sapiens 20-23 27135494-3 2014 The Nia1nit2 mutant with defects in genes encoding the nitrate reductase and regulatory protein NIT2 respectively was found to exhibit normal chemotaxis to nitrite. Nitrites 156-163 uncharacterized protein Chlamydomonas reinhardtii 96-100 24425765-9 2014 Exposure to 10 U/ml interleukin-1beta decreased GSIS and COX activity in both CDs and CDr islets, inducing a similar nitrite production. Nitrites 117-124 interleukin 1 beta Rattus norvegicus 20-37 24055935-1 2014 This work presents a novel bienzymatic biosensor for the simultaneous determination of nitrite (NO2(-)) and nitrate (NO3(-)) ions using copper, zinc superoxide dismutase (SOD1) and nitrate reductase (NaR) coimmobilized on carbon nanotubes (CNT)-polypyrrole (PPy) nanocomposite modified platinum electrode. Nitrites 87-94 superoxide dismutase 1 Homo sapiens 171-175 24361899-7 2014 In addition, the level of nitrite in the homogenized paw tissue, as determined by a colorimetric assay, indicated that exogenous Ang-(1-7) is able to induce NO release. Nitrites 26-33 angiogenin Rattus norvegicus 129-137 24406683-2 2014 For example, capacity to catalyze the one electron reduction of nitrite (NO2-) to NO has been reported for hemoglobin, myoglobin and molybdopterin-containing enzymes including xanthine oxidoreductase (XOR) and aldehyde oxidase (AO). Nitrites 64-71 xanthine dehydrogenase Homo sapiens 177-200 24406683-2 2014 For example, capacity to catalyze the one electron reduction of nitrite (NO2-) to NO has been reported for hemoglobin, myoglobin and molybdopterin-containing enzymes including xanthine oxidoreductase (XOR) and aldehyde oxidase (AO). Nitrites 64-71 xanthine dehydrogenase Homo sapiens 202-205 24406683-2 2014 For example, capacity to catalyze the one electron reduction of nitrite (NO2-) to NO has been reported for hemoglobin, myoglobin and molybdopterin-containing enzymes including xanthine oxidoreductase (XOR) and aldehyde oxidase (AO). Nitrites 64-71 aldehyde oxidase 1 Homo sapiens 211-227 24406683-2 2014 For example, capacity to catalyze the one electron reduction of nitrite (NO2-) to NO has been reported for hemoglobin, myoglobin and molybdopterin-containing enzymes including xanthine oxidoreductase (XOR) and aldehyde oxidase (AO). Nitrites 64-71 aldehyde oxidase 1 Homo sapiens 229-231 24627754-7 2014 RESULTS: At the presence of AT2R, the serum level of nitrite in response to AngII administration in OVE groups increased significantly (P < 0.05). Nitrites 53-60 angiotensin II receptor, type 2 Rattus norvegicus 28-32 24449851-6 2014 Furthermore, cryptic sulfur cycling was shown to attenuate the secondary nitrite maximum often observed in OMZs owing to changes in the composition of the chemolithoautotrophic community and dominant metabolic pathways. Nitrites 73-80 cripto, FRL-1, cryptic family 1 Homo sapiens 13-20 24269637-6 2014 Whereas AdXBP1S can inhibit ER stress-mediated apoptosis and TNFalpha induced nitrite production in OA cartilage. Nitrites 78-85 tumor necrosis factor Homo sapiens 61-69 24363367-5 2014 We identified the sulfite transporters Ssu1 and Ssu2 as effective nitrate exporters, Ssu2 being quantitatively more important, and we characterize the Nar1 protein as a nitrate/nitrite exporter. Nitrites 177-184 iron-sulfur cluster assembly protein NAR1 Saccharomyces cerevisiae S288C 151-155 24363367-7 2014 Growth test experiments indicated that Ssu2 and Nar1 exporters allow yeast to cope with nitrite toxicity. Nitrites 88-95 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 39-43 24363367-7 2014 Growth test experiments indicated that Ssu2 and Nar1 exporters allow yeast to cope with nitrite toxicity. Nitrites 88-95 iron-sulfur cluster assembly protein NAR1 Saccharomyces cerevisiae S288C 48-52 24363367-8 2014 We also have shown that the well-known Saccharomyces cerevisiae sulfite efflux permease Ssu1 is also able to excrete nitrite and nitrate. Nitrites 117-124 Ssu1p Saccharomyces cerevisiae S288C 88-92 23720033-7 2014 However, nitrite oxidation was severely affected, especially at 20 g Cl(-) l(-1), in which a complete inhibition was observed. Nitrites 9-16 collectin subfamily member 10 Homo sapiens 69-79 24157451-0 2014 Dietary nitrite improves insulin signaling through GLUT4 translocation. Nitrites 8-15 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 51-56 24157451-9 2014 Collectively our data suggest that nitrite improves insulin signaling through restoration of NO-dependent nitrosation of GLUT4 signaling translocation. Nitrites 35-42 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 121-126 24157451-10 2014 These data suggest that NO-mediated nitrosation of GLUT4 by nitrite or other nitrosating agents is necessary and sufficient for GLUT4 translocation in target tissue. Nitrites 60-67 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 51-56 24157451-10 2014 These data suggest that NO-mediated nitrosation of GLUT4 by nitrite or other nitrosating agents is necessary and sufficient for GLUT4 translocation in target tissue. Nitrites 60-67 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 128-133 24627754-7 2014 RESULTS: At the presence of AT2R, the serum level of nitrite in response to AngII administration in OVE groups increased significantly (P < 0.05). Nitrites 53-60 angiotensinogen Rattus norvegicus 76-81 24627754-9 2014 It seems that AT2R involves nitrite production response to AngII in OVE. Nitrites 28-35 angiotensin II receptor, type 2 Rattus norvegicus 14-18 24627754-9 2014 It seems that AT2R involves nitrite production response to AngII in OVE. Nitrites 28-35 angiotensinogen Rattus norvegicus 59-64 24005237-8 2014 Cytokines also upregulated transcriptions of NFKB1 and STAT1, which was accompanied by a significant increase in NOS2 transcription and accumulation of nitrite in culture medium, implicating nitrosative stress. Nitrites 152-159 nuclear factor kappa B subunit 1 Homo sapiens 45-50 23953980-0 2014 Myoglobin"s novel role in nitrite-induced hypoxic vasodilation. Nitrites 26-33 myoglobin Homo sapiens 0-9 23953980-4 2014 We have unraveled the heme-protein myoglobin in vascular smooth muscle cells as a major source of NO generation by reduction of endogenous nitrite under hypoxia. Nitrites 139-146 myoglobin Homo sapiens 35-44 24441717-5 2014 Plasma nitrate and nitrite (NOx) were markedly high with upregulation of inducible nitric oxide synthase (iNOS) expression, but dowregulation of endothelial nitric oxide synthase (eNOS) expression (p<0.05). Nitrites 19-26 nitric oxide synthase 2 Rattus norvegicus 73-104 24441717-5 2014 Plasma nitrate and nitrite (NOx) were markedly high with upregulation of inducible nitric oxide synthase (iNOS) expression, but dowregulation of endothelial nitric oxide synthase (eNOS) expression (p<0.05). Nitrites 19-26 nitric oxide synthase 2 Rattus norvegicus 106-110 24416422-3 2014 In this study, we have identified human cystathionine ss-synthase (CBS) as a new player in nitrite reduction with implications for the nitrite-dependent control of H2S production. Nitrites 91-98 cystathionine beta-synthase Homo sapiens 67-70 24416422-3 2014 In this study, we have identified human cystathionine ss-synthase (CBS) as a new player in nitrite reduction with implications for the nitrite-dependent control of H2S production. Nitrites 135-142 cystathionine beta-synthase Homo sapiens 67-70 24416422-4 2014 This novel activity of CBS exploits the catalytic property of its unusual heme cofactor to reduce nitrite and generate NO. Nitrites 98-105 cystathionine beta-synthase Homo sapiens 23-26 24416422-5 2014 Evidence for the possible physiological relevance of this reaction is provided by the formation of ferrous-nitrosyl (Fe(II)-NO) CBS in the presence of NADPH, the human diflavin methionine synthase reductase (MSR) and nitrite. Nitrites 217-224 cystathionine beta-synthase Homo sapiens 128-131 24416422-5 2014 Evidence for the possible physiological relevance of this reaction is provided by the formation of ferrous-nitrosyl (Fe(II)-NO) CBS in the presence of NADPH, the human diflavin methionine synthase reductase (MSR) and nitrite. Nitrites 217-224 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 208-211 24416422-8 2014 The participation of a regulatory heme cofactor in CBS in nitrite reduction is unexpected and expands the repertoire of proteins that can liberate NO from the intracellular nitrite pool. Nitrites 58-65 cystathionine beta-synthase Homo sapiens 51-54 24416422-8 2014 The participation of a regulatory heme cofactor in CBS in nitrite reduction is unexpected and expands the repertoire of proteins that can liberate NO from the intracellular nitrite pool. Nitrites 173-180 cystathionine beta-synthase Homo sapiens 51-54 24005237-8 2014 Cytokines also upregulated transcriptions of NFKB1 and STAT1, which was accompanied by a significant increase in NOS2 transcription and accumulation of nitrite in culture medium, implicating nitrosative stress. Nitrites 152-159 signal transducer and activator of transcription 1 Homo sapiens 55-60 24164360-0 2014 Aldehyde dehydrogenase 2 partly mediates hypotensive effect of nitrite on L-NAME-induced hypertension in normoxic rat. Nitrites 63-70 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 0-24 25115184-14 2014 The increased amount of SNO mtCx43 by IPC or nitrite administration may link NO and Cx43 in the signal transduction cascade of cardioprotective interventions. Nitrites 45-52 gap junction protein, alpha 1 Rattus norvegicus 30-34 23979125-4 2014 The objectives of this study were to investigate effects of the Maillard reaction on the interaction of methemoglobin (metHb) with S-nitrosoglutathione (GSNO) and nitrite. Nitrites 163-170 hemoglobin subunit gamma 2 Homo sapiens 104-117 24183883-8 2014 In multiple regression analysis homocysteine, sVCAM-1, and urinary nitrate/nitrite remained independent determinants of resistin levels (R(2) adjusted=0.347, p=0.000). Nitrites 75-82 resistin Homo sapiens 120-128 24346018-2 2014 Subsets of circulating blood cells, including red blood cells (RBCs), carry a NOS3 and contribute to blood pressure regulation and RBC nitrite/nitrate formation. Nitrites 135-142 nitric oxide synthase 3, endothelial cell Mus musculus 78-82 24383074-4 2014 The radical Cl2(- ) would also be a major oxidant of nitrite to the nitrating agent ( )NO2 in brackish- and salt-water. Nitrites 53-60 endogenous retrovirus group W member 5 Homo sapiens 12-15 24164360-3 2014 Because of a recent report of aldehyde dehydrogenase 2 (ALDH2)-catalyzed glyceryl trinitrate (GTN) vasorelaxation by denitration of GTN to 1,2-glyceryl dinitrate (1,2-GDN) and nitrite, we therefore investigated a catalytic activity of ALDH2 for nitrite reduction and subsequent effect on N(omega)-nitro-l-arginine methyl ester (l-NAME)-induced hypertension in normoxic rat. Nitrites 176-183 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 30-54 24164360-3 2014 Because of a recent report of aldehyde dehydrogenase 2 (ALDH2)-catalyzed glyceryl trinitrate (GTN) vasorelaxation by denitration of GTN to 1,2-glyceryl dinitrate (1,2-GDN) and nitrite, we therefore investigated a catalytic activity of ALDH2 for nitrite reduction and subsequent effect on N(omega)-nitro-l-arginine methyl ester (l-NAME)-induced hypertension in normoxic rat. Nitrites 176-183 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 56-61 24164360-3 2014 Because of a recent report of aldehyde dehydrogenase 2 (ALDH2)-catalyzed glyceryl trinitrate (GTN) vasorelaxation by denitration of GTN to 1,2-glyceryl dinitrate (1,2-GDN) and nitrite, we therefore investigated a catalytic activity of ALDH2 for nitrite reduction and subsequent effect on N(omega)-nitro-l-arginine methyl ester (l-NAME)-induced hypertension in normoxic rat. Nitrites 245-252 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 30-54 24164360-3 2014 Because of a recent report of aldehyde dehydrogenase 2 (ALDH2)-catalyzed glyceryl trinitrate (GTN) vasorelaxation by denitration of GTN to 1,2-glyceryl dinitrate (1,2-GDN) and nitrite, we therefore investigated a catalytic activity of ALDH2 for nitrite reduction and subsequent effect on N(omega)-nitro-l-arginine methyl ester (l-NAME)-induced hypertension in normoxic rat. Nitrites 245-252 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 56-61 24164360-8 2014 These results suggest that ALDH2 may be at least in part involved in nitrite-mediated hypotensive effects and nitrite catalysis in many organs of normoxic rats. Nitrites 69-76 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 27-32 24164360-8 2014 These results suggest that ALDH2 may be at least in part involved in nitrite-mediated hypotensive effects and nitrite catalysis in many organs of normoxic rats. Nitrites 110-117 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 27-32 24135863-5 2014 RESULTS: VIP could prevent the upregulation of IL-6, MCP-1, and nitrite production and maintain the production of IL-10 and TGF-beta under LPS (10 microg/ml) stimulation after 48 h of coculture. Nitrites 64-71 vasoactive intestinal peptide Homo sapiens 9-12 24009258-0 2014 Nitrite anion therapy protects against chronic ischemic tissue injury in db/db diabetic mice in a NO/VEGF-dependent manner. Nitrites 0-7 vascular endothelial growth factor A Mus musculus 101-105 24009258-8 2014 Nitrite therapy significantly increased ischemic tissue vascular endothelial growth factor (VEGF) protein expression that was essential for nitrite-mediated reperfusion of ischemic hind limbs. Nitrites 0-7 vascular endothelial growth factor A Mus musculus 56-90 24009258-8 2014 Nitrite therapy significantly increased ischemic tissue vascular endothelial growth factor (VEGF) protein expression that was essential for nitrite-mediated reperfusion of ischemic hind limbs. Nitrites 0-7 vascular endothelial growth factor A Mus musculus 92-96 24009258-8 2014 Nitrite therapy significantly increased ischemic tissue vascular endothelial growth factor (VEGF) protein expression that was essential for nitrite-mediated reperfusion of ischemic hind limbs. Nitrites 140-147 vascular endothelial growth factor A Mus musculus 56-90 24009258-8 2014 Nitrite therapy significantly increased ischemic tissue vascular endothelial growth factor (VEGF) protein expression that was essential for nitrite-mediated reperfusion of ischemic hind limbs. Nitrites 140-147 vascular endothelial growth factor A Mus musculus 92-96 24009258-10 2014 Lastly, nitrite treatment also significantly stimulated hypoxic endothelial cell proliferation and migration in the presence of high glucose in an NO/VEGF-dependent manner. Nitrites 8-15 vascular endothelial growth factor A Mus musculus 150-154 24271207-1 2014 In this article, we consider, in detail, the second half-cycle of the six-electron nitrite reduction mechanism catalyzed by cytochrome c nitrite reductase. Nitrites 83-90 cytochrome c, somatic Homo sapiens 124-136 25125800-4 2014 Regarding secretory activity, GHR decreased P4 in early CL, but increased PGF2alpha , nitrite and TNF in mid CL. Nitrites 86-93 ghrelin and obestatin prepropeptide Equus caballus 30-33 25125800-5 2014 Conversely, LEP increased P4, PGE2, angiogenic activity, MIF, TNF and nitrite during early CL, in a dose-dependent manner. Nitrites 70-77 leptin Equus caballus 12-15 23993458-3 2014 It has been demonstrated that ultrasound can produce NOx (nitrate and nitrite), with a production rate of 2.2 muM min(-1). Nitrites 70-77 latexin Homo sapiens 110-113 24259683-4 2014 Expression in Xenopus laevis oocytes and two-electrode voltage clamp measurements showed that VvNPF3.2 is a low-affinity transporter for both nitrate and nitrite and displays characteristics of NPF members from other plants. Nitrites 154-161 protein NRT1/ PTR FAMILY 3.1 Vitis vinifera 94-102 24259683-5 2014 We also cloned the Arabidopsis ortholog, AtNPF3.1, and showed that AtNPF3.1 similarly transported nitrate and nitrite with low affinity. Nitrites 110-117 Major facilitator superfamily protein Arabidopsis thaliana 41-49 24259683-5 2014 We also cloned the Arabidopsis ortholog, AtNPF3.1, and showed that AtNPF3.1 similarly transported nitrate and nitrite with low affinity. Nitrites 110-117 Major facilitator superfamily protein Arabidopsis thaliana 67-75 25187978-12 2014 In the group with ED, the serum level of endothelin 1 was higher compared with the group without ED (0.57 +-0.18 vs. 0.49 +-0.21 pg/ml; P = 0.032) and that of nitrates and nitrites was lower compared with the group without ED (15.2 [11.1-29.9] vs. 22.8 [16.9-33.0] mumol/l; P = 0.0005). Nitrites 172-180 endothelin 1 Homo sapiens 41-53 25187978-14 2014 In the group with ED, PTH inversely correlated with nitrates and nitrites (R = -0.48; P = 0.003). Nitrites 65-73 parathyroid hormone Homo sapiens 22-25 25187978-15 2014 CONCLUSIONS: In women with AH and without ED, PTH affected the production of a vasoconstrictor, endothelin 1, while in those with ED, PTH was associated with a lower production of vasodilators, nitrates and nitrites, by the vascular endothelium. Nitrites 207-215 parathyroid hormone Homo sapiens 46-49 24474630-5 2014 We provide genetic and pharmacological evidence that NO production from intracellular nitrite governs this degradation pathway: Addition of a NO scavenger and of two distinct NO producers decrease and increase, respectively, the rate of cytochrome b6f degradation; NO-sensitive fluorescence probes, visualized by confocal microscopy, demonstrate that nitrogen-starved cells produce NO only when the cytochrome b6f degradation pathway is activated. Nitrites 86-93 cytochrome b Chlamydomonas reinhardtii 237-249 24474630-5 2014 We provide genetic and pharmacological evidence that NO production from intracellular nitrite governs this degradation pathway: Addition of a NO scavenger and of two distinct NO producers decrease and increase, respectively, the rate of cytochrome b6f degradation; NO-sensitive fluorescence probes, visualized by confocal microscopy, demonstrate that nitrogen-starved cells produce NO only when the cytochrome b6f degradation pathway is activated. Nitrites 86-93 cytochrome b Chlamydomonas reinhardtii 399-411 25187978-15 2014 CONCLUSIONS: In women with AH and without ED, PTH affected the production of a vasoconstrictor, endothelin 1, while in those with ED, PTH was associated with a lower production of vasodilators, nitrates and nitrites, by the vascular endothelium. Nitrites 207-215 endothelin 1 Homo sapiens 96-108 25187978-15 2014 CONCLUSIONS: In women with AH and without ED, PTH affected the production of a vasoconstrictor, endothelin 1, while in those with ED, PTH was associated with a lower production of vasodilators, nitrates and nitrites, by the vascular endothelium. Nitrites 207-215 parathyroid hormone Homo sapiens 134-137 24200110-7 2013 Pretreatment of mice with BPP via oral or intraperitoneal (ip) administration for 2 weeks resulted in the suppression of LPS/GalN-induced catalase, superoxide dismutase (SOD), and transaminase (GOT/GPT) liver enzymes, amelioration of necrotic liver lesions, and reduction of tumor necrosis factor alpha (TNF-alpha) and nitrite serum levels as well as myeloperoxidase (MPO) activity, an index of necrotic injury. Nitrites 319-326 galanin and GMAP prepropeptide Mus musculus 125-129 24494186-8 2014 Nitrite also displayed therapeutic effects by ameliorating established colonic inflammation with reduced colonic expression of iNOS and improving histopathology. Nitrites 0-7 nitric oxide synthase 2, inducible Mus musculus 127-131 23703110-5 2013 Using fish oil (0.0368 g EPA and 0.0184 g DHA, per day), melatonin (10 mg/kg/day), and vitamin E (50 mg/Kg/day) we have now shown that COX-2 activity, LPO and nitrite/nitrate levels were significantly increased in MPTP treated mice (p < 0.001) while fish oil, melatonin and vitamin E treatment were capable of decreasing significantly the outcome of all above noted parameters (p < 0.05). Nitrites 159-166 cytochrome c oxidase II, mitochondrial Mus musculus 135-140 24064205-0 2013 Catalysis of nitrite generation from nitroglycerin by glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Nitrites 13-20 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 54-94 24064205-0 2013 Catalysis of nitrite generation from nitroglycerin by glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Nitrites 13-20 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 96-101 24064205-2 2013 We report here that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the release of nitrite from GTN. Nitrites 94-101 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 20-60 24064205-2 2013 We report here that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the release of nitrite from GTN. Nitrites 94-101 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 62-67 24064205-3 2013 In assays containing dithiothreitol (DTT) and NAD(+), the GTN reductase activity of purified GAPDH produces nitrite and 1,2-GDN as the major products. Nitrites 108-115 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 93-98 24064205-4 2013 A vmax of 2.6nmolmin(-)(1)mg(-)(1) was measured for nitrite production by GAPDH from rabbit muscle and a GTN KM of 1.2mM. Nitrites 52-59 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 74-79 24089378-1 2013 Nitric oxide (NO) is metabolized in plasma, in part by the ferroxidase ceruloplasmin (Cp), to form nitrite and nitrosothiols (SNOs), which are proposed to mediate protective responses to hypoxia and ischemia. Nitrites 99-106 ceruloplasmin Homo sapiens 71-84 24363996-12 2013 In addition, treatment with cLA and nitrite abolished MI-induced protein expression of p53 and dynamin-related protein-1 (DRP-1). Nitrites 36-43 transformation related protein 53, pseudogene Mus musculus 87-90 24363996-12 2013 In addition, treatment with cLA and nitrite abolished MI-induced protein expression of p53 and dynamin-related protein-1 (DRP-1). Nitrites 36-43 dynamin 1-like Mus musculus 95-120 24145454-8 2013 Thus, whether or not Mtb is hypoxic, the host expresses iNOS, or hypoxia impairs the action of iNOS, Mtb in vivo is likely to encounter RNS by producing nitrite. Nitrites 153-160 nitric oxide synthase 2, inducible Mus musculus 95-99 24363996-12 2013 In addition, treatment with cLA and nitrite abolished MI-induced protein expression of p53 and dynamin-related protein-1 (DRP-1). Nitrites 36-43 dynamin 1-like Mus musculus 122-127 24363996-13 2013 Moreover, the antioxidant enzyme expression of heme oxygenase-1 (HO-1) was elevated in MI mice treated with cLA and nitrite compared to untreated MI mice. Nitrites 116-123 heme oxygenase 1 Mus musculus 47-63 24363996-13 2013 Moreover, the antioxidant enzyme expression of heme oxygenase-1 (HO-1) was elevated in MI mice treated with cLA and nitrite compared to untreated MI mice. Nitrites 116-123 heme oxygenase 1 Mus musculus 65-69 23793091-7 2013 Residual nitrite and nitrate associated with fresh NEF and nitrate in NEF cooked LL were found (P<0.05) in the outer layer. Nitrites 9-16 S100 calcium binding protein B Homo sapiens 51-54 23609920-8 2013 RESULTS: IL-1beta treatment (range, 5-40 ng/ml) for 24 h was positively correlated with nitrite production (R2=0.9668, p<0.01), a significant increase in the percentage of apoptotic cells (p<0.01) and a concomitant dose-dependent increase in cytoplasmic levels of iNOS and NF-kappaB p65 activation. Nitrites 88-95 interleukin 1 beta Mus musculus 9-17 23793091-7 2013 Residual nitrite and nitrate associated with fresh NEF and nitrate in NEF cooked LL were found (P<0.05) in the outer layer. Nitrites 9-16 S100 calcium binding protein B Homo sapiens 70-73 24012847-2 2013 The purpose of this work was to find the optimal combination of influent ammonium (NH4(+)-Ninf), dissolved oxygen (DO) and the alkalinity/ammonium ratio (Alk/NH4(+)-N) with respect to the effluent nitrite to ammonium molar ratio and nitrite accumulation ratio. Nitrites 197-204 ALK receptor tyrosine kinase Homo sapiens 154-157 24012847-2 2013 The purpose of this work was to find the optimal combination of influent ammonium (NH4(+)-Ninf), dissolved oxygen (DO) and the alkalinity/ammonium ratio (Alk/NH4(+)-N) with respect to the effluent nitrite to ammonium molar ratio and nitrite accumulation ratio. Nitrites 233-240 ALK receptor tyrosine kinase Homo sapiens 154-157 25518555-5 2013 We established that a NO scavenger, hemoglobin (4 muM), fully or partially removed the toxic effect of SNP, nitrate, and nitrite on growth. Nitrites 121-128 latexin Homo sapiens 50-53 23609920-11 2013 CONCLUSIONS: These results suggest that exendin-4 protects against IL-1beta- induced apoptosis in beta-cells via downregulation of the NF- kappaB-iNOS-nitrite pathway. Nitrites 151-158 interleukin 1 beta Mus musculus 67-75 23609920-11 2013 CONCLUSIONS: These results suggest that exendin-4 protects against IL-1beta- induced apoptosis in beta-cells via downregulation of the NF- kappaB-iNOS-nitrite pathway. Nitrites 151-158 nitric oxide synthase 2, inducible Mus musculus 146-150 23852130-0 2013 Synthesis of fluorescent gold nanoclusters directed by bovine serum albumin and application for nitrite detection. Nitrites 96-103 albumin Homo sapiens 62-75 23852130-1 2013 In the present work, gold nanocluster (GNC) induced by bovine serum albumin (BSA) was synthesized as a novel fluorescence probe to detect nitrite (NO2(-)) sensitively and selectively. Nitrites 138-145 albumin Homo sapiens 62-75 23850530-6 2013 Acidosis and IL-1beta increased nitrite/nitrate release, but increases were moderate at 2% O2 and significantly reduced at <1% O2. Nitrites 32-39 interleukin 1 beta Homo sapiens 13-21 23454592-0 2013 Xanthine oxidoreductase-catalyzed reduction of nitrite to nitric oxide: insights regarding where, when and how. Nitrites 47-54 xanthine dehydrogenase Homo sapiens 0-23 23454592-5 2013 As such, information herein serves to link recent reports in which XOR activity has been identified as mediating the beneficial outcomes resulting from nitrite supplementation to a microenvironmental setting where XOR can serve as substantial source of NO. Nitrites 152-159 xanthine dehydrogenase Homo sapiens 67-70 23811105-6 2013 The activity of SOD and CAT decreased with the amount of nitrate and nitrite, while GSHPx and TBARS resulted unaffected. Nitrites 69-76 catalase Homo sapiens 24-27 23942037-7 2013 Bilirubin production by HO-1 inducers correlated with their potency in inhibiting nitrite production after challenge with interferon-gamma (INF-gamma) or lipopolysaccharide (LPS). Nitrites 82-89 heme oxygenase 1 Mus musculus 24-28 23941776-5 2013 TNF increased eNOS mRNA level and NO metabolite (nitrite) production during CL growth. Nitrites 49-56 tumor necrosis factor Equus caballus 0-3 23941776-6 2013 Cytokines combined action (TNF+IFNG+FASL) promoted eNOS protein upregulation in mid-CL and nitrite production in mid and late-CL. Nitrites 91-98 tumor necrosis factor Equus caballus 27-30 23941776-6 2013 Cytokines combined action (TNF+IFNG+FASL) promoted eNOS protein upregulation in mid-CL and nitrite production in mid and late-CL. Nitrites 91-98 interferon gamma Equus caballus 31-35 23941776-6 2013 Cytokines combined action (TNF+IFNG+FASL) promoted eNOS protein upregulation in mid-CL and nitrite production in mid and late-CL. Nitrites 91-98 Fas ligand Equus caballus 36-40 23941776-7 2013 However, in late-CL, TNF alone decreased nitrite secretion. Nitrites 41-48 tumor necrosis factor Equus caballus 21-24 23959559-9 2013 Furthermore, in vitro studies demonstrated that ET1 suppresses endothelial nitric oxide (NO) production, assessed by its metabolite nitrite, an effect associated with Rho-associated protein kinase-dependent changes in the phosphorylation state of endothelial NO synthase. Nitrites 132-139 endothelin 1 Mus musculus 48-51 23942037-7 2013 Bilirubin production by HO-1 inducers correlated with their potency in inhibiting nitrite production after challenge with interferon-gamma (INF-gamma) or lipopolysaccharide (LPS). Nitrites 82-89 interferon gamma Mus musculus 122-138 23942037-7 2013 Bilirubin production by HO-1 inducers correlated with their potency in inhibiting nitrite production after challenge with interferon-gamma (INF-gamma) or lipopolysaccharide (LPS). Nitrites 82-89 interferon gamma Mus musculus 140-149 23942037-8 2013 The compounds down-regulated the inflammatory response (TNF-alpha, PGE2 and nitrite) more strongly in cells challenged with INF-gamma than LPS, and silencing HO-1 or Nrf2 with shRNA differentially affected the levels of inflammatory markers. Nitrites 76-83 interferon gamma Mus musculus 124-133 23876348-0 2013 Simvastatin treatment increases nitrite levels in obese women: modulation by T(-786)C polymorphism of eNOS. Nitrites 32-39 nitric oxide synthase 3 Homo sapiens 102-106 23747519-0 2013 PG201 downregulates the production of nitrite by upregulating heme oxygenase-1 expression through the control of phosphatidylinositol 3-kinase and NF-E2-related factor 2. Nitrites 38-45 heme oxygenase 1 Mus musculus 62-78 23747519-0 2013 PG201 downregulates the production of nitrite by upregulating heme oxygenase-1 expression through the control of phosphatidylinositol 3-kinase and NF-E2-related factor 2. Nitrites 38-45 nuclear factor, erythroid derived 2, like 2 Mus musculus 147-169 23876348-4 2013 Moreover, we verified whether obese women carrying the C variant of T(-786)C polymorphism located in eNOS may have increased levels of nitrite after treatment compared to TT genotype. Nitrites 135-142 nitric oxide synthase 3 Homo sapiens 101-105 23747519-8 2013 Furthermore, the results from an experiment involving a specific siRNA and chemical inhibitors for HO-1 showed that the PG201-mediated increase of the HO-1 protein contributed to the suppression of inducible nitric oxide synthase (iNOS) and nitrite production stimulated by lipopolysaccharide. Nitrites 241-248 heme oxygenase 1 Mus musculus 99-103 23747519-8 2013 Furthermore, the results from an experiment involving a specific siRNA and chemical inhibitors for HO-1 showed that the PG201-mediated increase of the HO-1 protein contributed to the suppression of inducible nitric oxide synthase (iNOS) and nitrite production stimulated by lipopolysaccharide. Nitrites 241-248 heme oxygenase 1 Mus musculus 151-155 23702660-0 2013 Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis. Nitrites 113-120 nitric oxide synthase 3, endothelial cell Mus musculus 18-51 23943655-12 2013 In the unstable group, the total concentration of nitrite and nitrate at the last visit was 9.84 (6.65-11.24) muM. Nitrites 50-57 latexin Homo sapiens 110-113 23643962-0 2013 Relationship between adiponectin and nitrite in healthy and preeclampsia pregnancies. Nitrites 37-44 adiponectin, C1Q and collagen domain containing Homo sapiens 21-32 23643962-4 2013 No previous study has examined whether a positive correlation exists between adiponectin and nitrite in HP and PE and how ADMA may interfere with this correlation. Nitrites 93-100 adiponectin, C1Q and collagen domain containing Homo sapiens 77-88 23550806-8 2013 Treatment with BDNF or dbcAMP decreased EtOH or EtOH-activated microglial conditioned medium-induced changes in the levels of intracellular free radicals, ROS and O2-, nitrite, GSH, and catalase. Nitrites 168-175 brain-derived neurotrophic factor Rattus norvegicus 15-19 23702660-1 2013 OBJECTIVE: Mice genetically deficient in endothelial nitric oxide synthase (eNOS(-/-)) are hypertensive with lower circulating nitrite levels, indicating the importance of constitutively produced nitric oxide (NO ) to blood pressure regulation and vascular homeostasis. Nitrites 127-134 nitric oxide synthase 3, endothelial cell Mus musculus 41-74 24244809-5 2013 The p38 MAPK inhibitor abrogated the LPS-induced nitrite production, whereas the MEK-1 inhibitor did not affect the nitrite production. Nitrites 49-56 mitogen-activated protein kinase 14 Mus musculus 4-12 23769322-0 2013 Post-anoxic denitrification via nitrite driven by PHB in feast-famine sequencing batch reactor. Nitrites 32-39 prohibitin 1 Homo sapiens 50-53 23715557-6 2013 ILK deletion restored the vascular response to SNP after chronic oral nitrite administration. Nitrites 70-77 integrin linked kinase Mus musculus 0-3 23946691-3 2013 Nitrite production in the presence of PD98059, a specific inhibitor of the extracellular signal-regulated protein kinase-1 and 2 (ERK1/2) pathway, was dramatically diminished, suggesting that the ERK1/2 pathway is involved in CM-induced iNOS expression. Nitrites 0-7 mitogen-activated protein kinase 3 Mus musculus 130-136 23946691-3 2013 Nitrite production in the presence of PD98059, a specific inhibitor of the extracellular signal-regulated protein kinase-1 and 2 (ERK1/2) pathway, was dramatically diminished, suggesting that the ERK1/2 pathway is involved in CM-induced iNOS expression. Nitrites 0-7 mitogen-activated protein kinase 3 Mus musculus 196-202 23946691-3 2013 Nitrite production in the presence of PD98059, a specific inhibitor of the extracellular signal-regulated protein kinase-1 and 2 (ERK1/2) pathway, was dramatically diminished, suggesting that the ERK1/2 pathway is involved in CM-induced iNOS expression. Nitrites 0-7 nitric oxide synthase 2, inducible Mus musculus 237-241 23903463-6 2013 Nitrite sequestered by RBC interacts more extensively with deoxyhemoglobin, which contributes greatly to methemoglobin formation. Nitrites 0-7 hemoglobin subunit gamma 2 Homo sapiens 105-118 23903463-7 2013 Methemoglobin is formed less-than-proportionally at higher nitrite doses as characterized with facilitated methemoglobin removal. Nitrites 59-66 hemoglobin subunit gamma 2 Homo sapiens 0-13 23903463-7 2013 Methemoglobin is formed less-than-proportionally at higher nitrite doses as characterized with facilitated methemoglobin removal. Nitrites 59-66 hemoglobin subunit gamma 2 Homo sapiens 107-120 24024174-10 2013 Hb-Fe(II)-NO that is formed from nitrite reduction under ~50% O2, then transfers NO(+) to either Hb-Cys beta93 or directly to PDI resulting in S-nitroso-PDI which transverses the RBC membrane and attaches to the RBC surface. Nitrites 33-40 prolyl 4-hydroxylase subunit beta Homo sapiens 126-129 24024174-0 2013 Protein disulfide isomerase may facilitate the efflux of nitrite derived S-nitrosothiols from red blood cells. Nitrites 57-64 prolyl 4-hydroxylase subunit beta Homo sapiens 0-27 24024174-4 2013 PDI was S-nitrosylated when RBCs were exposed to nitrite under ~50% oxygen saturation but not under ~100% oxygen saturation. Nitrites 49-56 prolyl 4-hydroxylase subunit beta Homo sapiens 0-3 24024174-10 2013 Hb-Fe(II)-NO that is formed from nitrite reduction under ~50% O2, then transfers NO(+) to either Hb-Cys beta93 or directly to PDI resulting in S-nitroso-PDI which transverses the RBC membrane and attaches to the RBC surface. Nitrites 33-40 prolyl 4-hydroxylase subunit beta Homo sapiens 153-156 24024174-11 2013 When RBCs enter tissues the S-nitroso-PDI is released from the RBC-surface into the blood where its NO(+) is transferred into the endothelium thereby inducing vasodilation, suggesting local oxygen-dependent dynamic interplays between nitrite, NO and S-nitrosylation. Nitrites 234-241 prolyl 4-hydroxylase subunit beta Homo sapiens 38-41 23747724-8 2013 CCL-1 also activated microglia morphologically, promoted mRNA levels for brain-derived neurotrophic factor (BDNF) and IL-6, and increased the release of nitrite from microglia. Nitrites 153-160 C-C motif chemokine ligand 1 Homo sapiens 0-5 24024174-5 2013 Furthermore, it was observed that hemoglobin (Hb) could promote PDI S-nitrosylation in the presence of ~600 nM nitrite. Nitrites 111-118 prolyl 4-hydroxylase subunit beta Homo sapiens 64-67 23609145-3 2013 Bisulfite and nitrite also inhibited PCFT function at neutral pH, whereas sulfate, nitrate, and phosphate had no impact at all. Nitrites 14-21 solute carrier family 46 member 1 Homo sapiens 37-41 23609145-4 2013 At weakly acidic pH (6.5), bisulfite and nitrite exhibited much stronger inhibition of PCFT-mediated transport, whereas sulfate and nitrate remained noninhibitory. Nitrites 41-48 solute carrier family 46 member 1 Homo sapiens 87-91 23697506-4 2013 The extract inhibited superoxide production by NADPH oxidase in THP-1 cells and nitrite production in J774A.1 cells stimulated with LPS+IFNgamma, with nitrite production decreasing after 4 h of incubation with the extract, mainly through a strong scavenging activity. Nitrites 151-158 interferon gamma Mus musculus 136-144 23799981-8 2013 Also, nitrite concentration was elevated in G3 compared to G1 (140+-29 muM vs 111+-29 muM, for G3 and G1, respectively, p<0.0001). Nitrites 6-13 BAG cochaperone 6 Homo sapiens 95-104 23650378-0 2013 Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Nitrites 115-122 toll-like receptor 4 Mus musculus 12-16 23795274-10 2013 SCD late menarche group had significantly low level of plasma nitrite concentration for all 3 eNOS gene polymorphisms as compared to controls and SCD early menarche females. Nitrites 62-69 nitric oxide synthase 3, endothelial cell Mus musculus 94-98 23470627-7 2013 Chronic inhibition of polyamine synthesis using an ornithine decarboxylase inhibitor significantly reduced polyamine levels, restored nitrite/nitrate levels to normal, and abrogated the AHR to methacholine in the acute model of allergic airways inflammation. Nitrites 134-141 ornithine decarboxylase, structural 1 Mus musculus 51-74 23650378-6 2013 Strikingly, compared with formula, human and mouse breast milk were enriched in sodium nitrate--a precursor for enteral generation of nitrite and nitric oxide--and repletion of formula with sodium nitrate/nitrite restored intestinal perfusion, reversed the deleterious effects of endothelial TLR4 signaling, and reduced NEC severity. Nitrites 205-212 toll-like receptor 4 Mus musculus 292-296 23500665-6 2013 The plasma nitrite level decreased with GA, GANP and cGANP (most pronounced for cGANP) treated group as compared to saline treated control group while no change in plasma corticosterone levels was observed in any treatment. Nitrites 11-18 minichromosome maintenance complex component 3 associated protein Mus musculus 44-48 23356444-8 2013 Plasma nitrite/nitrate levels were lower in patients with CSX than control subjects (15.9 +- 1.6 mumol/L vs. 25.4 +- 2.8 mumol/L, respectively; P < 0.001), and they have a significantly positive correlation with plasma adropin levels (r = 0.463, P < 0.001). Nitrites 7-14 NK2 homeobox 5 Homo sapiens 58-61 23356444-9 2013 In the multiple linear regression analysis, nitrite/nitrate levels, BMI, and adropin were found to be independent risk factors for CSX. Nitrites 44-51 NK2 homeobox 5 Homo sapiens 131-134 23536322-11 2013 NaK-Ni7-Ale2 proved to be efficient for the electrocatalytic reduction of nitrate, nitrite and nitrous oxide. Nitrites 83-90 TANK binding kinase 1 Homo sapiens 0-3 23545404-2 2013 Both nitrite and HNO oxidize oxygenated hemoglobin to methemoglobin. Nitrites 5-12 hemoglobin subunit gamma 2 Homo sapiens 54-67 23545404-5 2013 We have demonstrated this HNO mediated acceleration of the nitrite/oxygenated hemoglobin reaction with oxygenated hemoglobin being in excess to HNO and nitrite (as would be found under physiological conditions) by monitoring the formation of methemoglobin in the presence of Angeli"s salt with and without added NO2(-). Nitrites 59-66 hemoglobin subunit gamma 2 Homo sapiens 242-255 23545404-5 2013 We have demonstrated this HNO mediated acceleration of the nitrite/oxygenated hemoglobin reaction with oxygenated hemoglobin being in excess to HNO and nitrite (as would be found under physiological conditions) by monitoring the formation of methemoglobin in the presence of Angeli"s salt with and without added NO2(-). Nitrites 152-159 hemoglobin subunit gamma 2 Homo sapiens 242-255 23759982-1 2013 Extending our previous observations, we have shown on HaCat cells that melatonin, at ~10-9 M concentration, transiently raises not only the expression of the neuronal nitric oxide synthase (nNOS) mRNA, but also the nNOS protein synthesis and the nitric oxide oxidation products, nitrite and nitrate. Nitrites 279-286 nitric oxide synthase 1 Homo sapiens 190-194 23930182-11 2013 The serum and kidney levels of nitrite were not significantly different between I/R and sham groups; however, administration of EPO increased the renal level of nitrite (P < 0.05). Nitrites 31-38 erythropoietin Rattus norvegicus 128-131 23930182-11 2013 The serum and kidney levels of nitrite were not significantly different between I/R and sham groups; however, administration of EPO increased the renal level of nitrite (P < 0.05). Nitrites 161-168 erythropoietin Rattus norvegicus 128-131 23223086-12 2013 However, in PE, Hp2-1 and Hp2-2 were associated with higher plasma heme levels (48 and 55% higher, respectively; P<0.05), increased NO consumption (42 and 44% more, respectively; P<0.05) and lower plasma nitrite (39% less for Hp2-2; P<0.05) compared with Hp1-1. Nitrites 210-217 ADP ribosylation factor like GTPase 6 interacting protein 5 Homo sapiens 26-31 23589565-9 2013 Our observations demonstrate the improved efficacy of inorganic nitrate and nitrite in hypertension as a consequence of increased erythrocytic XOR nitrite reductase activity and support the concept of dietary nitrate supplementation as an effective, but simple and inexpensive, antihypertensive strategy. Nitrites 76-83 xanthine dehydrogenase Homo sapiens 143-146 23373571-7 2013 KEY RESULTS: LPS caused a significant production of nitrites, associated to up-regulation of anandamide, iNOS, COX-2, CB1 receptors and down-regulation of CB2 receptors mRNA expression. Nitrites 52-60 nitric oxide synthase 2, inducible Mus musculus 105-109 23373571-7 2013 KEY RESULTS: LPS caused a significant production of nitrites, associated to up-regulation of anandamide, iNOS, COX-2, CB1 receptors and down-regulation of CB2 receptors mRNA expression. Nitrites 52-60 prostaglandin-endoperoxide synthase 2 Mus musculus 111-116 23373571-7 2013 KEY RESULTS: LPS caused a significant production of nitrites, associated to up-regulation of anandamide, iNOS, COX-2, CB1 receptors and down-regulation of CB2 receptors mRNA expression. Nitrites 52-60 cannabinoid receptor 1 (brain) Mus musculus 118-121 23373571-7 2013 KEY RESULTS: LPS caused a significant production of nitrites, associated to up-regulation of anandamide, iNOS, COX-2, CB1 receptors and down-regulation of CB2 receptors mRNA expression. Nitrites 52-60 cannabinoid receptor 2 (macrophage) Mus musculus 155-158 23376235-7 2013 In the 27 patients on dialysis, baseline plasma nitrite and nitrate by HPLC were 0.21+-0.03 and 67.25+-14.68 muM, respectively. Nitrites 48-55 latexin Homo sapiens 109-112 23776725-9 2013 Also, the measurement of nitrite concentration showed significantly greater levels of dissolved NO2/NO3 metabolite in the culture media of HUVECs treated by sera of AD patients (P < 0.05), while the rate of nitric oxide significantly decreased when pioglitazone exists in culture media. Nitrites 25-32 NBL1, DAN family BMP antagonist Homo sapiens 100-103 23463757-10 2013 ATbG-NOS3 haplotype homozygosity was associated with up to 64% higher nitrite/nitrate levels (P=0.003). Nitrites 70-77 nitric oxide synthase 3 Homo sapiens 5-9 23463362-7 2013 With this method, 1 muM of nitrite could be detected by the perception of yellow color in solution and less than 0.5 muM of nitrite be quantified with a spectrophotometer. Nitrites 27-34 latexin Homo sapiens 20-23 23463362-7 2013 With this method, 1 muM of nitrite could be detected by the perception of yellow color in solution and less than 0.5 muM of nitrite be quantified with a spectrophotometer. Nitrites 124-131 latexin Homo sapiens 20-23 23463362-7 2013 With this method, 1 muM of nitrite could be detected by the perception of yellow color in solution and less than 0.5 muM of nitrite be quantified with a spectrophotometer. Nitrites 124-131 latexin Homo sapiens 117-120 22751257-0 2013 Adiponectin associates positively with nitrite levels in children and adolescents. Nitrites 39-46 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 23428073-9 2013 Compared to the others, the bowknot-shaped and sphere-shaped CuO products exhibit excellent electrocatalytic activity toward nitrite oxidation and fast current response in nitrite sensing because of their peculiar hierarchical structures with high BET surface areas and well-ordered pores. Nitrites 125-132 delta/notch like EGF repeat containing Homo sapiens 248-251 23428073-9 2013 Compared to the others, the bowknot-shaped and sphere-shaped CuO products exhibit excellent electrocatalytic activity toward nitrite oxidation and fast current response in nitrite sensing because of their peculiar hierarchical structures with high BET surface areas and well-ordered pores. Nitrites 172-179 delta/notch like EGF repeat containing Homo sapiens 248-251 23567270-6 2013 Purified, recombinant PGIS showed a half-maximal nitration by 10 muM 3-morpholino sydnonimine (Sin-1) which increased in the presence of bicarbonate, and was only marginally induced by freely diffusing NO2-radicals generated by a peroxidase/nitrite/hydrogen peroxide system. Nitrites 241-248 MAPK associated protein 1 Homo sapiens 95-100 23435580-1 2013 We have developed a Boolean NAND logic gate for the fluorescent detection of nitrite ions by using bovine serum albumin (BSA) functionalized gold nanoclusters. Nitrites 77-84 albumin Homo sapiens 106-119 23515834-8 2013 According to Canonical Correspondence Analysis, pH, temperature, nitrite, and nitrate concentration strongly affected the diversity and distribution of anammox bacteria in South China Sea sediments. Nitrites 65-72 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 184-187 23313075-6 2013 PRL added to the CG compartment increased the ovarian release of P, estradiol, nitrites and PGF2alpha, and decreased the Bcl-2/Bax ratio in non-lactating rats; yet, with the exception of a reduction in the release of nitrites, such parameters were not modified in lactating animals. Nitrites 79-87 prolactin Rattus norvegicus 0-3 23313075-6 2013 PRL added to the CG compartment increased the ovarian release of P, estradiol, nitrites and PGF2alpha, and decreased the Bcl-2/Bax ratio in non-lactating rats; yet, with the exception of a reduction in the release of nitrites, such parameters were not modified in lactating animals. Nitrites 217-225 prolactin Rattus norvegicus 0-3 23441627-8 2013 The high NOS-2 expression coincided with an exacerbated NO production in the infection focus and in plasma, as judging by nitrate + nitrite levels. Nitrites 132-139 nitric oxide synthase 2, inducible Mus musculus 9-14 23142117-5 2013 RESULTS: Nitrite treatment was associated with better oxygenation, lower peak airway pressure, lower wet/dry ratio, reduced myeloperoxidase level and macrophage infiltration, increased cyclic guanosine monophosphate (cGMP) levels, and decreased levels of interleukin 6, interleukin 1-beta, inducible nitric oxide synthase, and intercellular adhesion molecule-1 at 2 hours after reperfusion. Nitrites 9-16 myeloperoxidase Rattus norvegicus 124-139 23142117-5 2013 RESULTS: Nitrite treatment was associated with better oxygenation, lower peak airway pressure, lower wet/dry ratio, reduced myeloperoxidase level and macrophage infiltration, increased cyclic guanosine monophosphate (cGMP) levels, and decreased levels of interleukin 6, interleukin 1-beta, inducible nitric oxide synthase, and intercellular adhesion molecule-1 at 2 hours after reperfusion. Nitrites 9-16 interleukin 6 Rattus norvegicus 255-268 23142117-5 2013 RESULTS: Nitrite treatment was associated with better oxygenation, lower peak airway pressure, lower wet/dry ratio, reduced myeloperoxidase level and macrophage infiltration, increased cyclic guanosine monophosphate (cGMP) levels, and decreased levels of interleukin 6, interleukin 1-beta, inducible nitric oxide synthase, and intercellular adhesion molecule-1 at 2 hours after reperfusion. Nitrites 9-16 interleukin 1 beta Rattus norvegicus 270-288 23142117-5 2013 RESULTS: Nitrite treatment was associated with better oxygenation, lower peak airway pressure, lower wet/dry ratio, reduced myeloperoxidase level and macrophage infiltration, increased cyclic guanosine monophosphate (cGMP) levels, and decreased levels of interleukin 6, interleukin 1-beta, inducible nitric oxide synthase, and intercellular adhesion molecule-1 at 2 hours after reperfusion. Nitrites 9-16 intercellular adhesion molecule 1 Rattus norvegicus 327-360 26105861-10 2013 In the subgroup CC+CT the MPO levels were higher in HBP as well as nitrites, leucocytes, neutrophils, Apo B, BMI, waist and ratio waist/hip compared with NT (p<0.001, p=0.04, p=0.042, p=0.035, p=0.03, p=0.022, p=0.026, respectively). Nitrites 67-75 myeloperoxidase Homo sapiens 26-29 23626887-6 2013 However, administration of Ang II in male and female rats caused a gender difference in the nitrite level, which resulted in the serum level of the nitrite significantly increasing in males (P < 0.05) when compared with the females. Nitrites 148-155 angiotensinogen Rattus norvegicus 27-33 23416542-1 2013 The first examples of inorganic nitrite complexes of the natural actinides are described, including the structures of the homoleptic thorium(IV) [PPh(4)](2)[Th(NO(2))(6)] and the uranyl(VI) [PPh(4)](2)[UO(2)(NO(2))(4)] complexes; the nitrite ligand can adopt two different coordination modes in the coordination sphere of the uranyl ion and is unstable towards reduction. Nitrites 32-39 potassium two pore domain channel subfamily K member 3 Homo sapiens 146-152 23626887-6 2013 However, administration of Ang II in male and female rats caused a gender difference in the nitrite level, which resulted in the serum level of the nitrite significantly increasing in males (P < 0.05) when compared with the females. Nitrites 92-99 angiotensinogen Rattus norvegicus 27-33 23416542-1 2013 The first examples of inorganic nitrite complexes of the natural actinides are described, including the structures of the homoleptic thorium(IV) [PPh(4)](2)[Th(NO(2))(6)] and the uranyl(VI) [PPh(4)](2)[UO(2)(NO(2))(4)] complexes; the nitrite ligand can adopt two different coordination modes in the coordination sphere of the uranyl ion and is unstable towards reduction. Nitrites 32-39 potassium two pore domain channel subfamily K member 3 Homo sapiens 191-197 23626887-7 2013 In addition, masR blockade or co-blockade of masR and AT2R in male rats abolished the gender difference related to the effect of Ang II on nitrite production. Nitrites 139-146 angiotensin II receptor, type 2 Rattus norvegicus 54-58 23626887-7 2013 In addition, masR blockade or co-blockade of masR and AT2R in male rats abolished the gender difference related to the effect of Ang II on nitrite production. Nitrites 139-146 angiotensinogen Rattus norvegicus 129-135 23626887-8 2013 In the presence of masR and AT2R, or when masR alone was blocked, the level of nitrite in the kidney, in response to the Ang II infusion was not significantly different between the two sexes. Nitrites 79-86 angiotensin II receptor, type 2 Rattus norvegicus 28-32 23626887-8 2013 In the presence of masR and AT2R, or when masR alone was blocked, the level of nitrite in the kidney, in response to the Ang II infusion was not significantly different between the two sexes. Nitrites 79-86 angiotensinogen Rattus norvegicus 121-127 23626887-9 2013 On the contrary, masR and AT2R co-blockades significantly decreased the kidney nitrite concentration response to Ang II administration in both male and female rats (P < 0.05), but no sex difference was detected. Nitrites 79-86 angiotensin II receptor, type 2 Rattus norvegicus 26-30 23626887-9 2013 On the contrary, masR and AT2R co-blockades significantly decreased the kidney nitrite concentration response to Ang II administration in both male and female rats (P < 0.05), but no sex difference was detected. Nitrites 79-86 angiotensinogen Rattus norvegicus 113-119 23336596-9 2013 To illustrate these features, the separation of four anions within 16 s is demonstrated as well as the determination of nitrite below 1 muM. Nitrites 120-127 latexin Homo sapiens 136-139 23288160-8 2013 Ex vivo study showed that, compared with controls, platelets from carriers of NOX2 deficiency had lower isoprostanes (P<0.001) and higher nitrite/nitrate (P<0.001), whereas platelets from obese women had higher isoprostanes (P<0.001) and lower nitrite/nitrate (P=0.013). Nitrites 141-148 cytochrome b-245 beta chain Homo sapiens 78-82 23288160-8 2013 Ex vivo study showed that, compared with controls, platelets from carriers of NOX2 deficiency had lower isoprostanes (P<0.001) and higher nitrite/nitrate (P<0.001), whereas platelets from obese women had higher isoprostanes (P<0.001) and lower nitrite/nitrate (P=0.013). Nitrites 253-260 cytochrome b-245 beta chain Homo sapiens 78-82 23209301-7 2013 In the presence of H(2)O(2), rIDO catalytically consumed nitric oxide (NO) and utilized nitrite to promote 3-nitrotyrosine formation on IDO. Nitrites 88-95 indoleamine 2,3-dioxygenase 1 Homo sapiens 30-33 23402357-8 2013 The mean total nitrite level (muM) was statistically higher (P = .0069) in implants with mucositis (14.34 +- 11.83) than in control teeth (9.316 +- 5.534). Nitrites 15-22 latexin Homo sapiens 30-33 23149826-8 2013 Interestingly, the co-administration of peroxisome proliferator-activated receptor gamma (PPARgamma) antagonist, GW9662 (1 mg/kg/day, i.p., 2 weeks) submaximally, significantly prevented rosuvastatin-induced improvement in vascular endothelial integrity, endothelium-dependent relaxation, and nitrite/nitrate concentration in rats administered nicotine. Nitrites 293-300 peroxisome proliferator-activated receptor gamma Rattus norvegicus 40-88 23149826-8 2013 Interestingly, the co-administration of peroxisome proliferator-activated receptor gamma (PPARgamma) antagonist, GW9662 (1 mg/kg/day, i.p., 2 weeks) submaximally, significantly prevented rosuvastatin-induced improvement in vascular endothelial integrity, endothelium-dependent relaxation, and nitrite/nitrate concentration in rats administered nicotine. Nitrites 293-300 peroxisome proliferator-activated receptor gamma Rattus norvegicus 90-99 23279126-10 2013 A significant increase of nitrite/nitrate levels was observed in the first 5 min after inducing I/R and was significantly reduced by N(omega) -propyl-l-arginine and 1400 W, selective inhibitors of nNOS and iNOS, respectively. Nitrites 26-33 nitric oxide synthase, brain Cavia porcellus 197-201 23279126-10 2013 A significant increase of nitrite/nitrate levels was observed in the first 5 min after inducing I/R and was significantly reduced by N(omega) -propyl-l-arginine and 1400 W, selective inhibitors of nNOS and iNOS, respectively. Nitrites 26-33 nitric oxide synthase, inducible Cavia porcellus 206-210 23597900-3 2013 The fluorescence intensity decreased linearly upon the increasing concentration of nitrite in a wide range of 2.0x10(-8) M to 5.0x10(-5) M. The detection limit was only 1.0 nM (S/N=3), which was much lower than the maximum admissible concentration of 2.2 muM required by the European Community. Nitrites 83-90 latexin Homo sapiens 255-258 23069892-0 2013 Effects of endothelial nitric oxide synthase tagSNPs haplotypes on nitrite levels in black subjects. Nitrites 67-74 nitric oxide synthase 3 Homo sapiens 11-44 23099167-4 2013 The linear calibration range for nitrite was 0.04-0.8 mug mL(-1) with a detection limit of 13.6 ng mL(-1) (S/N=3.29). Nitrites 33-40 L1 cell adhesion molecule Mus musculus 58-64 23099167-4 2013 The linear calibration range for nitrite was 0.04-0.8 mug mL(-1) with a detection limit of 13.6 ng mL(-1) (S/N=3.29). Nitrites 33-40 L1 cell adhesion molecule Mus musculus 99-105 23099167-5 2013 The relative standard deviation for ten determinations of 0.1 and 0.4 mug mL(-1) nitrite were 1.38% and 2.01%, respectively. Nitrites 81-88 L1 cell adhesion molecule Mus musculus 74-80 24313368-7 2013 Concomitantly, the (15)N abundances of nitrite and ammonium in soil water increased and lead to the conclusion that, besides commonly known NO3(-) reduction to nitrite (i.e. denitrification), a dissimilatory nitrate reduction to ammonium has simultaneously taken place. Nitrites 160-167 NBL1, DAN family BMP antagonist Homo sapiens 140-143 24024215-5 2013 It was reported previously that interferon gamma (IFN-gamma) and nitric oxide synthase 2 (NOS2) are expressed on alveolar macrophages from TB patients and are responsible for bacilli control; thus, we aimed this study at genotyping single nucleotide polymorphisms IFNG+874T/A SNP and NOS2A-954G/C SNP to estimate their role on TB susceptibility and determine whether these polymorphisms influence serum nitrite and NOx(-) production. Nitrites 403-410 interferon gamma Homo sapiens 32-59 24024215-5 2013 It was reported previously that interferon gamma (IFN-gamma) and nitric oxide synthase 2 (NOS2) are expressed on alveolar macrophages from TB patients and are responsible for bacilli control; thus, we aimed this study at genotyping single nucleotide polymorphisms IFNG+874T/A SNP and NOS2A-954G/C SNP to estimate their role on TB susceptibility and determine whether these polymorphisms influence serum nitrite and NOx(-) production. Nitrites 403-410 nitric oxide synthase 2 Homo sapiens 65-88 24024215-5 2013 It was reported previously that interferon gamma (IFN-gamma) and nitric oxide synthase 2 (NOS2) are expressed on alveolar macrophages from TB patients and are responsible for bacilli control; thus, we aimed this study at genotyping single nucleotide polymorphisms IFNG+874T/A SNP and NOS2A-954G/C SNP to estimate their role on TB susceptibility and determine whether these polymorphisms influence serum nitrite and NOx(-) production. Nitrites 403-410 nitric oxide synthase 2 Homo sapiens 90-94 22981699-8 2013 Unbound NO could be generated at 410 muM nitrite in the HbA simulation by lowering the pH. Nitrites 41-48 latexin Homo sapiens 37-40 22981699-14 2013 The failure of 410 muM nitrite to generate unbound NO in the HbA simulation at pH 7.4, contrasts with evidence in the literature showing that exposure of intact red cells to 100 to 200 muM nitrite in PBS, promoted NO release into the gas phase. Nitrites 189-196 latexin Homo sapiens 185-188 23711618-6 2013 RESULTS: Three-year IFNbeta-1a or IFNbeta-1b monotherapy reduced serum nitrite levels by 77 and 71%, respectively, lowered multiple sclerosis relapse annual rate by 70 and 71%, respectively, and significantly and similarly lowered Expanded Disability Status Scale scores in both study groups (by 0.9 on average). Nitrites 71-78 interferon beta 1 Homo sapiens 20-27 23008504-8 2013 However, the level of nitrate and nitrite, substrates of cytochrome P450 reductase, were higher in SHR than WKY plasma and aortae. Nitrites 34-41 cytochrome p450 oxidoreductase Rattus norvegicus 57-82 23711618-6 2013 RESULTS: Three-year IFNbeta-1a or IFNbeta-1b monotherapy reduced serum nitrite levels by 77 and 71%, respectively, lowered multiple sclerosis relapse annual rate by 70 and 71%, respectively, and significantly and similarly lowered Expanded Disability Status Scale scores in both study groups (by 0.9 on average). Nitrites 71-78 interferon beta 1 Homo sapiens 34-41 23183119-9 2013 Macrophages of the early phase of sepsis pretreated with OXT and stimulated with lipopolysaccharide showed decreased nitrite, TNF-alpha and IL-1beta levels, but no alteration in IL-10 production. Nitrites 117-124 oxytocin/neurophysin I prepropeptide Rattus norvegicus 57-60 23765348-3 2013 Nitrite and/or nitric oxide may influence muscle contractile efficiency perhaps via effects on sarcoplasmic reticulum calcium handling or actin-myosin interaction, and may also improve the efficiency of mitochondrial oxidative phosphorylation. Nitrites 0-7 myosin heavy chain 14 Homo sapiens 144-150 22961095-6 2013 The iNOS inhibitors significantly inhibited the acrolein-increased nitrite/nitrate levels, but not IL-6 levels. Nitrites 67-74 nitric oxide synthase 2 Rattus norvegicus 4-8 23004358-7 2013 We found that a low ammonium/nitrate ratio in growth media leads to a higher level of nitrite-dependent nitric oxide (NO) production in nudt6-2 nudt7, and NO acts in a positive feedback loop with EDS1 to promote the autoimmunity. Nitrites 86-93 nudix hydrolase homolog 6 Arabidopsis thaliana 136-141 23004358-7 2013 We found that a low ammonium/nitrate ratio in growth media leads to a higher level of nitrite-dependent nitric oxide (NO) production in nudt6-2 nudt7, and NO acts in a positive feedback loop with EDS1 to promote the autoimmunity. Nitrites 86-93 MutT/nudix family protein Arabidopsis thaliana 144-149 23004358-7 2013 We found that a low ammonium/nitrate ratio in growth media leads to a higher level of nitrite-dependent nitric oxide (NO) production in nudt6-2 nudt7, and NO acts in a positive feedback loop with EDS1 to promote the autoimmunity. Nitrites 86-93 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 196-200 24396568-4 2013 TNF-alpha increased the levels of superoxide, Nox (nitrate and nitrite), malondialdehyde, and nitrotyrosine production, accompanied by increased protein expression of p-PKC-beta2, gP91phox, and endothelial cell apoptosis, whereas all these changes were further enhanced by nitroglycerine. Nitrites 63-70 tumor necrosis factor Homo sapiens 0-9 23469284-13 2013 Plasma nitrate/nitrite level was significantly reduced in AngII-infused mice (P<0.05). Nitrites 15-22 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 58-63 23651488-2 2013 The aim of the present study was to analyze concentrations of nitrates and nitrites (NO2 + NO3) and L-arginine in patients with liver cirrhosis and HRS as a possible predictive marker for the development of HRS. Nitrites 75-83 NBL1, DAN family BMP antagonist Homo sapiens 91-94 23247127-11 2013 Physiological CCK concentration reduced nitrite and iNOS synthesis by peritoneal macrophages, possibly through a self-regulatory IL-10-dependent mechanism. Nitrites 40-47 cholecystokinin Rattus norvegicus 14-17 23787303-1 2013 ANITA Mox is a new one-stage deammonification Moving-Bed Biofilm Reactor (MBBR) developed for partial nitrification to nitrite and autotrophic N-removal from N-rich effluents. Nitrites 120-127 monooxygenase DBH like 1 Homo sapiens 7-10 23059132-9 2012 Notably, diversion of MPO from HOCl production by thiocyanate or nitrite attenuated de-adhesion and associated signaling responses, despite the latter substrate supporting MPO-catalyzed fibronectin nitration. Nitrites 65-72 myeloperoxidase Homo sapiens 22-25 23143065-4 2013 A cyclic AMP analog that specifically activates Epac, 8-(4-methoxyphenylthio)-2"-O-methyladenosine-3",5"-cyclic monophosphate (OPTmecAMP), and overexpression of liver-specific Epac2 both inhibited interleukin 1beta/interferon gamma-induced iNOS expression and nitrite production. Nitrites 260-267 Rap guanine nucleotide exchange factor 3 Homo sapiens 48-52 23143065-7 2013 A specific PI3K inhibitor, LY294002, attenuated the inhibition of nitrite production and iNOS expression produced by overexpressing a liver-specific Epac2 (LEpac2). Nitrites 66-73 Rap guanine nucleotide exchange factor 4 Homo sapiens 149-154 23143065-9 2013 Overexpression of dominant-negative JNK enhanced cytokine-induced iNOS expression and nitrite production and reversed the inhibitory effects of LEpac2 on nitrite production and iNOS expression. Nitrites 86-93 mitogen-activated protein kinase 8 Homo sapiens 36-39 23143065-9 2013 Overexpression of dominant-negative JNK enhanced cytokine-induced iNOS expression and nitrite production and reversed the inhibitory effects of LEpac2 on nitrite production and iNOS expression. Nitrites 154-161 mitogen-activated protein kinase 8 Homo sapiens 36-39 23144452-6 2012 Dietary CLA and nitrite supplementation in rodents elevates NO(2)-CLA levels in plasma, urine, and tissues, which in turn induces heme oxygenase-1 (HO-1) expression in the colonic epithelium. Nitrites 16-23 heme oxygenase 1 Homo sapiens 130-146 22537094-4 2012 When RAW264.7 cells and primary macrophages were preincubated with 11-oxoaerothionin and stimulated with LPS (lipopolysaccharide), a concentration-dependent inhibition of iNOS(inducible nitric oxide synthase) protein and NO(2)(-) (Nitrite) production were observed. Nitrites 231-238 nitric oxide synthase 2, inducible Mus musculus 171-175 22533969-9 2012 IL-1beta strongly increased the expression of inducible nitric oxide synthase (iNOS) mRNA and the nitrite concentration in both healthy and DIGO cells (p < 0.05). Nitrites 98-105 interleukin 1 beta Homo sapiens 0-8 23121672-6 2012 VIP decreased T-bet expression significantly, reduced monocyte chemotactic protein-1 (MCP-1) and nitrite production in co-cultures of PBMCs from fertile women with trophoblast cells; while it increased the frequency of CD4(+) CD25(+) forkhead box protein 3 (Foxp3)(+) cells, transforming growth factor (TGF)-beta expression and interleukin (IL)-10 secretion. Nitrites 97-104 vasoactive intestinal peptide Homo sapiens 0-3 22533969-10 2012 However, co-administration of IL-1beta and nifedipine largely abrogated the expression of iNOS mRNA and the nitrite concentration with the same treatment. Nitrites 108-115 interleukin 1 beta Homo sapiens 30-38 22796369-5 2012 KEY FINDINGS: In the presence of high concentrations of fibrinogen and ACh (10 muM) in the blood samples from healthy humans the erythrocyte nitrites, nitrates and GSNO concentrations increased without significant changes in NO efflux. Nitrites 141-149 fibrinogen beta chain Homo sapiens 56-66 23016570-5 2012 Nitrite treatment was associated with significantly higher levels of tissue oxygenation, lower levels of cytokines and neutrophil/macrophage infiltration, lower myeloperoxidase activity, reduced oxidative injury and increased cGMP levels in grafts than in the controls. Nitrites 0-7 myeloperoxidase Rattus norvegicus 161-176 22970427-1 2012 A simple colorimetric method with high sensitivity and selectivity was developed for sensing of nitrite as low as 4.0 muM by naked eyes, which is based on etching of gold nanorods accompanied by shape changes in aspect ratios (length/width) and a visible color change from bluish green to red and then to colorless with the increase of nitrite. Nitrites 96-103 latexin Homo sapiens 118-121 22970427-1 2012 A simple colorimetric method with high sensitivity and selectivity was developed for sensing of nitrite as low as 4.0 muM by naked eyes, which is based on etching of gold nanorods accompanied by shape changes in aspect ratios (length/width) and a visible color change from bluish green to red and then to colorless with the increase of nitrite. Nitrites 336-343 latexin Homo sapiens 118-121 23044819-6 2012 Subsequent biological evaluations revealed 3-carboxaldehyde oxime and cyano substituted 2-phenylindoles 5 and 7 exhibited the strongest nitrite inhibitory activities (IC(50) = 4.4 +- 0.5 and 4.8 +- 0.4 muM, respectively); as well as NFkappaB inhibition (IC(50) = 6.9 +- 0.8 and 8.5 +- 2.0 muM, respectively). Nitrites 136-143 latexin Homo sapiens 202-205 23044819-6 2012 Subsequent biological evaluations revealed 3-carboxaldehyde oxime and cyano substituted 2-phenylindoles 5 and 7 exhibited the strongest nitrite inhibitory activities (IC(50) = 4.4 +- 0.5 and 4.8 +- 0.4 muM, respectively); as well as NFkappaB inhibition (IC(50) = 6.9 +- 0.8 and 8.5 +- 2.0 muM, respectively). Nitrites 136-143 nuclear factor kappa B subunit 1 Homo sapiens 233-241 23044819-6 2012 Subsequent biological evaluations revealed 3-carboxaldehyde oxime and cyano substituted 2-phenylindoles 5 and 7 exhibited the strongest nitrite inhibitory activities (IC(50) = 4.4 +- 0.5 and 4.8 +- 0.4 muM, respectively); as well as NFkappaB inhibition (IC(50) = 6.9 +- 0.8 and 8.5 +- 2.0 muM, respectively). Nitrites 136-143 latexin Homo sapiens 289-292 23019216-3 2012 It was found that FUBEC constitutively express Toll-like receptor 4 (TLR4), a receptor of LPS, and respond to LPS (10 mug/ml) by stimulation of inducible nitric oxide synthase (iNOS) mRNA/protein expression and NOS activity measured by nitrite produced in the culture medium and by citrulline assay. Nitrites 236-243 toll like receptor 4 Canis lupus familiaris 47-67 23019216-3 2012 It was found that FUBEC constitutively express Toll-like receptor 4 (TLR4), a receptor of LPS, and respond to LPS (10 mug/ml) by stimulation of inducible nitric oxide synthase (iNOS) mRNA/protein expression and NOS activity measured by nitrite produced in the culture medium and by citrulline assay. Nitrites 236-243 toll like receptor 4 Canis lupus familiaris 69-73 23019216-3 2012 It was found that FUBEC constitutively express Toll-like receptor 4 (TLR4), a receptor of LPS, and respond to LPS (10 mug/ml) by stimulation of inducible nitric oxide synthase (iNOS) mRNA/protein expression and NOS activity measured by nitrite produced in the culture medium and by citrulline assay. Nitrites 236-243 nitric oxide synthase 2 Canis lupus familiaris 144-175 23019216-3 2012 It was found that FUBEC constitutively express Toll-like receptor 4 (TLR4), a receptor of LPS, and respond to LPS (10 mug/ml) by stimulation of inducible nitric oxide synthase (iNOS) mRNA/protein expression and NOS activity measured by nitrite produced in the culture medium and by citrulline assay. Nitrites 236-243 nitric oxide synthase 2 Canis lupus familiaris 177-181 22982594-8 2012 PPARdelta activation increased the total nitrite and nitrate (NO2+NO3) content in cerebral microvessels (P<0.05, n=6). Nitrites 41-48 peroxisome proliferator activator receptor delta Mus musculus 0-9 23016570-6 2012 Treatment with either a nitric oxide scavenger or a soluble guanylyl cyclase (sGC) inhibitor diminished the beneficial effects of nitrite and decreased cGMP concentrations. Nitrites 130-137 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 52-76 23016570-6 2012 Treatment with either a nitric oxide scavenger or a soluble guanylyl cyclase (sGC) inhibitor diminished the beneficial effects of nitrite and decreased cGMP concentrations. Nitrites 130-137 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 78-81 23016570-7 2012 These results suggest that nitric oxide, generated from nitrite, is the molecule responsible for the effects of nitrite via the nitric oxide/sGC/cGMP pathway. Nitrites 56-63 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 141-144 23016570-7 2012 These results suggest that nitric oxide, generated from nitrite, is the molecule responsible for the effects of nitrite via the nitric oxide/sGC/cGMP pathway. Nitrites 112-119 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 141-144 23016570-8 2012 Allopurinol, a xanthine oxidoreductase (XOR) inhibitor, abrogated the protective effects of nitrite, suggesting that XOR is a key enzyme in the conversion of nitrite to nitric oxide. Nitrites 92-99 xanthine dehydrogenase Rattus norvegicus 15-38 23016570-8 2012 Allopurinol, a xanthine oxidoreductase (XOR) inhibitor, abrogated the protective effects of nitrite, suggesting that XOR is a key enzyme in the conversion of nitrite to nitric oxide. Nitrites 92-99 xanthine dehydrogenase Rattus norvegicus 40-43 23016570-8 2012 Allopurinol, a xanthine oxidoreductase (XOR) inhibitor, abrogated the protective effects of nitrite, suggesting that XOR is a key enzyme in the conversion of nitrite to nitric oxide. Nitrites 92-99 xanthine dehydrogenase Rattus norvegicus 117-120 23016570-8 2012 Allopurinol, a xanthine oxidoreductase (XOR) inhibitor, abrogated the protective effects of nitrite, suggesting that XOR is a key enzyme in the conversion of nitrite to nitric oxide. Nitrites 158-165 xanthine dehydrogenase Rattus norvegicus 40-43 23016570-8 2012 Allopurinol, a xanthine oxidoreductase (XOR) inhibitor, abrogated the protective effects of nitrite, suggesting that XOR is a key enzyme in the conversion of nitrite to nitric oxide. Nitrites 158-165 xanthine dehydrogenase Rattus norvegicus 117-120 22917977-5 2012 Intraperitoneal nitrite decreased Cl(2)-dependent increases in BAL protein but not PMNs. Nitrites 16-23 solute carrier family 27 member 5 Rattus norvegicus 63-66 22683098-6 2012 RESULTS: We found that serum tNOx (total nitrite/nitrate; mumol/L) was lower in obese T2DM group (12.7+-3.5) when compared with their controls (21.1+-2.4), although the non-obese group presented higher concentration of tNOx (33.8+-7.2). Nitrites 41-48 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 29-33 22896706-0 2012 Characterization of the mechanism and magnitude of cytoglobin-mediated nitrite reduction and nitric oxide generation under anaerobic conditions. Nitrites 71-78 cytoglobin Homo sapiens 51-61 22896706-3 2012 The mechanism, magnitude, and quantitative importance of Cygb-mediated nitrite reduction in tissues have not been reported. Nitrites 71-78 cytoglobin Homo sapiens 57-61 22896706-5 2012 Under anaerobic conditions, mixing nitrite with ferrous-Cygb triggered NO formation that was trapped and detected using EPR spin trapping. Nitrites 35-42 cytoglobin Homo sapiens 56-60 22896706-6 2012 Spectrophotometric studies revealed that nitrite binding to ferrous-Cygb is followed by formation of ferric-Cygb and NO. Nitrites 41-48 cytoglobin Homo sapiens 68-72 22896706-6 2012 Spectrophotometric studies revealed that nitrite binding to ferrous-Cygb is followed by formation of ferric-Cygb and NO. Nitrites 41-48 cytoglobin Homo sapiens 108-112 22896706-8 2012 It was observed that Cygb-mediated NO generation increased linearly with the increase of nitrite concentration under anaerobic conditions. Nitrites 89-96 cytoglobin Homo sapiens 21-25 22896706-10 2012 With the addition of nitrite, soluble guanylyl cyclase activation was significantly higher in normal smooth muscle cells compared with Cygb knocked down cells with Cygb accounting for ~40% of the activation in control cells and ~60% in cells subjected to hypoxia for 48 h. Overall, these studies show that Cygb-mediated nitrite reduction can play an important role in NO generation and soluble guanylyl cyclase activation under hypoxic conditions, with this process regulated by pH, oxygen tension, nitrite concentration, and the redox state of the cells. Nitrites 320-327 cytoglobin Homo sapiens 164-168 22896706-10 2012 With the addition of nitrite, soluble guanylyl cyclase activation was significantly higher in normal smooth muscle cells compared with Cygb knocked down cells with Cygb accounting for ~40% of the activation in control cells and ~60% in cells subjected to hypoxia for 48 h. Overall, these studies show that Cygb-mediated nitrite reduction can play an important role in NO generation and soluble guanylyl cyclase activation under hypoxic conditions, with this process regulated by pH, oxygen tension, nitrite concentration, and the redox state of the cells. Nitrites 320-327 cytoglobin Homo sapiens 164-168 22896706-10 2012 With the addition of nitrite, soluble guanylyl cyclase activation was significantly higher in normal smooth muscle cells compared with Cygb knocked down cells with Cygb accounting for ~40% of the activation in control cells and ~60% in cells subjected to hypoxia for 48 h. Overall, these studies show that Cygb-mediated nitrite reduction can play an important role in NO generation and soluble guanylyl cyclase activation under hypoxic conditions, with this process regulated by pH, oxygen tension, nitrite concentration, and the redox state of the cells. Nitrites 320-327 cytoglobin Homo sapiens 164-168 22896706-10 2012 With the addition of nitrite, soluble guanylyl cyclase activation was significantly higher in normal smooth muscle cells compared with Cygb knocked down cells with Cygb accounting for ~40% of the activation in control cells and ~60% in cells subjected to hypoxia for 48 h. Overall, these studies show that Cygb-mediated nitrite reduction can play an important role in NO generation and soluble guanylyl cyclase activation under hypoxic conditions, with this process regulated by pH, oxygen tension, nitrite concentration, and the redox state of the cells. Nitrites 320-327 cytoglobin Homo sapiens 164-168 22947039-5 2012 However, Hcp2(+) GEI(-) or Hcp2(-) GEI(-) cells were unable to use lactate, causing sulfide to be used as electron donor for nitrite reduction at a sixfold lower rate. Nitrites 125-132 CYCS pseudogene 52 Homo sapiens 9-13 22947039-5 2012 However, Hcp2(+) GEI(-) or Hcp2(-) GEI(-) cells were unable to use lactate, causing sulfide to be used as electron donor for nitrite reduction at a sixfold lower rate. Nitrites 125-132 CYCS pseudogene 52 Homo sapiens 27-31 22947039-7 2012 Hcp2 enhanced the rate of nitrite reduction when, in addition to lactate, hydrogen was also present as an electron donor. Nitrites 26-33 CYCS pseudogene 52 Homo sapiens 0-4 22221676-8 2012 Quercetin significantly reduced IL-1beta-induced nitrite production, iNOS protein and its mRNA expression levels, and it also inhibited IL-1beta-induced IkappaBalpha phosphorylation, NF-kappaB activation and iNOS promoter activity. Nitrites 49-56 interleukin 1 beta Rattus norvegicus 32-40 23442723-2 2012 The method is based on the diazotization reaction of dapsone (4,4"-diamino-diphenyl sulphone, DAP) and (naphthyl)ethylenediamine hydrochloride (NED) with nitrite in acidic medium, yielding a coloured compound on the surface of a filter paper. Nitrites 154-161 death associated protein Homo sapiens 94-97 23293787-4 2012 Finally, increasing doses of the MEK inhibitors, PD98,059 or U0126,were incubated with mIMCD-3 cells and the ET-1 dependent nitrite production determined. Nitrites 124-131 midkine Mus musculus 33-36 23293787-4 2012 Finally, increasing doses of the MEK inhibitors, PD98,059 or U0126,were incubated with mIMCD-3 cells and the ET-1 dependent nitrite production determined. Nitrites 124-131 endothelin 1 Mus musculus 109-113 23293787-6 2012 ET-1 also stimulates nitrite production by mIMCD-3 cells (basal: 54.5+-26 pmol/mg pr/hvs ET-1: 221+-28 pmol/mg pr/h; N=4) via the ETB receptor (BQ788+ET-1: 83.7+-27 pmol/mg pr/h);however, ET-1 does not regulate NOS1 or NOS3 expression. Nitrites 21-28 endothelin 1 Mus musculus 0-4 23293787-8 2012 SIGNIFICANCE: Although the mouse IMCD-3 cells only express the NOS1beta splice variant, ET-1 did regulate mouse IMCD nitrite production. Nitrites 117-124 endothelin 1 Mus musculus 88-92 22917977-6 2012 In contrast im nitrite decreased BAL PMN levels without decreasing BAL protein in a xanthine oxidoreductase-dependent manner. Nitrites 15-22 solute carrier family 27 member 5 Rattus norvegicus 33-36 22917977-12 2012 Halving the im nitrite dose resulted in no effect in PMN accumulation but significant reduction of BAL protein levels, indicating a distinct nitrite dose dependence for inhibition of Cl(2)-dependent lung permeability and inflammation. Nitrites 15-22 solute carrier family 27 member 5 Rattus norvegicus 99-102 23316304-0 2012 Hydrogen sulfide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxia-inducible factor-1alpha and vascular endothelial growth factor-dependent angiogenesis. Nitrites 91-98 hypoxia inducible factor 1, alpha subunit Mus musculus 129-160 22892143-6 2012 We demonstrate that nitrite significantly increases cellular mitochondrial number by augmenting the activity of adenylate kinase, resulting in AMP kinase phosphorylation, downstream activation of sirtuin-1, and deacetylation of PGC1alpha, the master regulator of mitochondrial biogenesis. Nitrites 20-27 sirtuin 1 Rattus norvegicus 196-205 22892143-6 2012 We demonstrate that nitrite significantly increases cellular mitochondrial number by augmenting the activity of adenylate kinase, resulting in AMP kinase phosphorylation, downstream activation of sirtuin-1, and deacetylation of PGC1alpha, the master regulator of mitochondrial biogenesis. Nitrites 20-27 PPARG coactivator 1 alpha Rattus norvegicus 228-237 22892143-10 2012 This protection was accompanied by a nitrite-dependent upregulation of PGC1alpha and increased mitochondrial number in the injured artery. Nitrites 37-44 PPARG coactivator 1 alpha Rattus norvegicus 71-80 22627297-6 2012 The stress induced by titanium dioxide with nitrite under UVA irradiation in human keratinocyte cells appeared to trigger the apoptosis inducing factor mediated cell death and lose the inhibition of active caspase by cystatin-A. Nitrites 44-51 cystatin A Homo sapiens 217-227 23031518-5 2012 In consistent with previous findings, catalase has been shown to play a major role in modulating the nitrosative stress by oxidizing nitrite to nitrate. Nitrites 133-140 catalase Bos taurus 38-46 22819707-3 2012 The daily administration of L-NAME (50mg/kg) for six weeks along with DADS analogs (20 mg/kg) significantly decreased the elevated systolic blood pressure (SBP) and the activity of angiotensin converting enzyme (ACE) and also inhibited the decline in nitrite/nitrate (NO(x)) concentrations and cyclic guanosine monophosphate (cGMP) levels. Nitrites 251-258 angiotensin I converting enzyme Rattus norvegicus 212-215 22778404-12 2012 We suggest that the 2NO(3)(-)/H(+) transport function of sialin in salivary glands can contribute significantly to clearance of serum nitrate, as well as nitrate recycling and physiological nitrite-NO homeostasis. Nitrites 190-197 solute carrier family 17 member 5 Homo sapiens 57-63 22819108-4 2012 In vitro inducible nitric oxide synthase activity, determined as nitrite, was higher in MB49-I than in MB49 cells (p <0.001). Nitrites 65-72 nitric oxide synthase 2, inducible Mus musculus 9-40 22045831-9 2012 In contrast, plasma nitrite levels increased 24 hours after NAC plus DFX administration. Nitrites 20-27 synuclein alpha Homo sapiens 60-63 22741157-3 2012 From the peak intensity of the diazonium group, the presence of nitrite ions above 20 muM can be identified readily. Nitrites 64-71 latexin Homo sapiens 86-89 22741157-4 2012 From the peak intensity of the azo moiety alone, it is even possible to detect nitrite ions at concentrations as low as 5 muM, without interference from other anions. Nitrites 79-86 latexin Homo sapiens 122-125 22113643-6 2012 In the presence of nitrite at concentrations observed during inflammatory and infectious process (10-50 muM), nitroenkephalin, a nitrated derivative of Leu-enkephalin, is additionally formed. Nitrites 19-26 latexin Homo sapiens 104-107 22113643-6 2012 In the presence of nitrite at concentrations observed during inflammatory and infectious process (10-50 muM), nitroenkephalin, a nitrated derivative of Leu-enkephalin, is additionally formed. Nitrites 19-26 prodynorphin Homo sapiens 152-166 22788969-13 2012 In addition, pretreatment of the cells with STAT1 siRNA inhibited the phosphorylation of STAT1, iNOS expression, and nitrite production, and enhanced the release of sPLA2-IIA. Nitrites 117-124 signal transducer and activator of transcription 1 Homo sapiens 44-49 22969780-3 2012 Currently, the association of vitamin D (25-hydroxyvitamin D, 25-OH D) and PTH to nitric oxide metabolites (NOx) - nitrate and nitrite - and oxidative stress in African-Americans is unknown. Nitrites 127-134 parathyroid hormone Homo sapiens 75-78 22620259-4 2012 We found that the reaction of nitrite with deoxygenated AHb1 and AHb2 generates NO gas and iron-nitrosyl-hemoglobin species. Nitrites 30-37 hemoglobin 1 Arabidopsis thaliana 56-60 22620259-4 2012 We found that the reaction of nitrite with deoxygenated AHb1 and AHb2 generates NO gas and iron-nitrosyl-hemoglobin species. Nitrites 30-37 hemoglobin 2 Arabidopsis thaliana 65-69 22620259-7 2012 These results demonstrate that deoxygenated AHb1 and AHb2 reduce nitrite to form NO via a mechanism analogous to that observed for hemoglobin, myoglobin, and neuroglobin. Nitrites 65-72 hemoglobin 1 Arabidopsis thaliana 44-48 22620259-7 2012 These results demonstrate that deoxygenated AHb1 and AHb2 reduce nitrite to form NO via a mechanism analogous to that observed for hemoglobin, myoglobin, and neuroglobin. Nitrites 65-72 hemoglobin 2 Arabidopsis thaliana 53-57 22572914-7 2012 The beneficial effects of dietary nitrate and nitrite were reduced in mice lacking endothelial NO synthase or treated with the xanthine oxidoreductase inhibitor allopurinol. Nitrites 46-53 xanthine dehydrogenase Mus musculus 127-150 22537177-4 2012 Based on our results, we suggest that AOX respiration acts to reduce the generation of ROS and RNS in plant mitochondria by dampening the leak of single electrons from the electron transport chain to O(2) or nitrite. Nitrites 208-215 ubiquinol oxidase 1, mitochondrial Nicotiana tabacum 38-41 22572914-9 2012 This favorable pharmacodynamic profile depends on endothelial NO synthase and xanthine oxidoreductase -catalyzed reduction of nitrite to NO. Nitrites 126-133 xanthine dehydrogenase Mus musculus 78-101 21932058-2 2012 The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group. Nitrites 275-282 arginine vasopressin Homo sapiens 125-136 22526670-3 2012 This study aimed to investigate the fate of 6-MAM after exposure to nitrite and to identify any formed oxidation products that may potentially be used for monitoring heroin abuse despite nitrite adulteration. Nitrites 68-75 sarcoglycan gamma Homo sapiens 46-49 22526670-7 2012 Nitrite, under acidic environment (pH<7), was shown to be effective in masking the detection of 6-MAM by both the CEDIA immunoassay and the LC-MS methods. Nitrites 0-7 sarcoglycan gamma Homo sapiens 101-104 22526670-9 2012 2-Nitro-MAM was detectable in a urine sample of a heroin user after nitrite exposure. Nitrites 68-75 sarcoglycan gamma Homo sapiens 8-11 22526670-10 2012 2-Nitro-MAM has shown potential to serve as a marker for monitoring heroin abuse when urine is adulterated with nitrite. Nitrites 112-119 sarcoglycan gamma Homo sapiens 8-11 22547700-5 2012 Analysis of the inflammatory responses at the site of initial infection (peritoneal cavity) revealed that CLP TRPV1KO mice exhibited: 1) decreased mononuclear cell integrity associated with apoptosis, 2) decreased macrophage tachykinin NK(1)-dependent phagocytosis, 3) substantially decreased levels of nitrite (indicative of NO) and reactive oxygen species, 4) increased cytokine levels, and 5) decreased bacteria clearance when compared with CLP WT mice. Nitrites 303-310 hyaluronan and proteoglycan link protein 1 Mus musculus 106-109 22454108-1 2012 Cytochrome c nitrite reductase catalyzes the six-electron, seven-proton reduction of nitrite to ammonia without release of any detectable reaction intermediate. Nitrites 13-20 cytochrome c, somatic Homo sapiens 0-12 22484619-6 2012 Quantitative RT-PCR and immunoblotting experiments showed that Ang II (3h) increased the mRNA and protein expression of nNOS and increased NO production (nitrite assay) in LV myocyte homogenates, suggesting that nNOS activity may be enhanced and involved in mediating the effects of Ang II. Nitrites 154-161 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 63-69 22695420-9 2012 Nitrite treatment also reduced plasma levels of interleukin-6 and myeloperoxidase activities in muscle and lung tissues, finally resulting in a dose-dependent improvement of survival rate from 24% (CS group) to 36% (NaNO(2)-100 group) and 64% (NaNO(2)-200 and 500 groups). Nitrites 0-7 interleukin 6 Rattus norvegicus 48-61 22695420-9 2012 Nitrite treatment also reduced plasma levels of interleukin-6 and myeloperoxidase activities in muscle and lung tissues, finally resulting in a dose-dependent improvement of survival rate from 24% (CS group) to 36% (NaNO(2)-100 group) and 64% (NaNO(2)-200 and 500 groups). Nitrites 0-7 myeloperoxidase Rattus norvegicus 66-81 22425779-4 2012 Under normoxia, oxygenated myoglobin can scavenge excessive nitric oxide, while under hypoxia, deoxygenated myoglobin can reduce nitrite, an oxidative product of nitric oxide, to bioactive nitric oxide. Nitrites 129-136 myoglobin Homo sapiens 27-36 22425779-4 2012 Under normoxia, oxygenated myoglobin can scavenge excessive nitric oxide, while under hypoxia, deoxygenated myoglobin can reduce nitrite, an oxidative product of nitric oxide, to bioactive nitric oxide. Nitrites 129-136 myoglobin Homo sapiens 108-117 22484664-7 2012 Nitrite therapy did not alter post-arrest hemodynamics but did result in significant (75%) increases in CA1 neuron survival. Nitrites 0-7 carbonic anhydrase 1 Homo sapiens 104-107 22425779-5 2012 Myoglobin-driven nitrite reduction can protect the heart from ischemia and reperfusion injury. Nitrites 17-24 myoglobin Homo sapiens 0-9 22425779-6 2012 While horse and mouse myoglobin have been previously described to reduce nitrite under these conditions, a comparable activity has not been detected in human myoglobin. Nitrites 73-80 myoglobin Mus musculus 22-31 22425779-9 2012 The results revealed that oxygenated human myoglobin reacts with nitrite-derived nitric oxide to form ferric myoglobin and that deoxygenated human myoglobin acts as a nitrite reductase in vitro and in situ. Nitrites 65-72 myoglobin Homo sapiens 43-52 22425779-9 2012 The results revealed that oxygenated human myoglobin reacts with nitrite-derived nitric oxide to form ferric myoglobin and that deoxygenated human myoglobin acts as a nitrite reductase in vitro and in situ. Nitrites 65-72 myoglobin Homo sapiens 109-118 22425779-9 2012 The results revealed that oxygenated human myoglobin reacts with nitrite-derived nitric oxide to form ferric myoglobin and that deoxygenated human myoglobin acts as a nitrite reductase in vitro and in situ. Nitrites 65-72 myoglobin Homo sapiens 109-118 22425779-10 2012 Rates of both nitric oxide scavenging and nitrite reduction were significantly higher in human compared to horse myoglobin. Nitrites 42-49 myoglobin Equus caballus 113-122 22425780-0 2012 Normoxic cyclic GMP-independent oxidative signaling by nitrite enhances airway epithelial cell proliferation and wound healing. Nitrites 55-62 5'-nucleotidase, cytosolic II Homo sapiens 16-19 22504070-4 2012 Our results indicate nitrite has no effect on proliferation of stage 1 SW116 colon cancer cells, while nitrite inhibits proliferation of stage 2 SW480 at 10 nM-100 muM and inhibits stage 3 HCT15 proliferation at 100 nM-1 muM, but promotes a significant increase in proliferation on stage 4 COLO205 cells at 100 muM. Nitrites 103-110 latexin Homo sapiens 164-167 22425780-3 2012 Nitrite signaling has been described as NO dependent activation mediated by reactions with deoxygenated redox active hemoproteins, such as hemoglobin, myoglobin, neuroglobin, xanthine oxidoreductase (XO) and NO synthase at low pH and oxygen tension. Nitrites 0-7 neuroglobin Homo sapiens 162-173 22425780-3 2012 Nitrite signaling has been described as NO dependent activation mediated by reactions with deoxygenated redox active hemoproteins, such as hemoglobin, myoglobin, neuroglobin, xanthine oxidoreductase (XO) and NO synthase at low pH and oxygen tension. Nitrites 0-7 xanthine dehydrogenase Homo sapiens 175-198 22425780-10 2012 Consistent with an oxidative signaling pathway requiring hydrogen peroxide (H(2)O(2))/heme-peroxidase/NO(2) signaling, the effects of nitrite were potentiated by superoxide dismutase (SOD) and low concentration H(2)O(2), whereas inhibited completely by catalase, followed by downstream extracellular-signal-regulated kinase (ERK) 1/2 activation. Nitrites 135-142 mitogen-activated protein kinase 3 Homo sapiens 287-334 22504070-4 2012 Our results indicate nitrite has no effect on proliferation of stage 1 SW116 colon cancer cells, while nitrite inhibits proliferation of stage 2 SW480 at 10 nM-100 muM and inhibits stage 3 HCT15 proliferation at 100 nM-1 muM, but promotes a significant increase in proliferation on stage 4 COLO205 cells at 100 muM. Nitrites 103-110 latexin Homo sapiens 221-224 22504070-4 2012 Our results indicate nitrite has no effect on proliferation of stage 1 SW116 colon cancer cells, while nitrite inhibits proliferation of stage 2 SW480 at 10 nM-100 muM and inhibits stage 3 HCT15 proliferation at 100 nM-1 muM, but promotes a significant increase in proliferation on stage 4 COLO205 cells at 100 muM. Nitrites 103-110 latexin Homo sapiens 221-224 22504070-8 2012 However, 100 muM nitrite promoted cell cycle progression in COLO205 cells with increased S-phase entry. Nitrites 17-24 latexin Homo sapiens 13-16 22860400-4 2012 The per os administration of the NSE aqueous suspension in a dose of 50 mg/kg during 10 days to the rats with induced diabetes contributed to the normalization of catalase activity in the testis, which correlated with a decrease in the amount of TBA-reacting products and activity of superoxide dismutase and catalase in the blood plasma of animals; the use of NSE also contributed to the reduction of nitrite content in the gonads and to normalization of both nitrite and nitrate in the blood plasma of rats. Nitrites 402-409 enolase 2 Rattus norvegicus 33-36 22353229-9 2012 Treatment with zinc protoporphyrin, a selective inhibitor of HO-1, significantly reversed the ARGE-mediated inhibition of nitrite production (P < 0.05). Nitrites 122-129 heme oxygenase 1 Mus musculus 61-65 22359381-9 2012 Secretion of Wnt3a from aortic valve endothelium in the presence of abnormal oxidative stress was correlated with diminished eNOS enzymatic activity and tissue nitrite levels. Nitrites 160-167 wingless-type MMTV integration site family, member 3A Mus musculus 13-18 22860400-4 2012 The per os administration of the NSE aqueous suspension in a dose of 50 mg/kg during 10 days to the rats with induced diabetes contributed to the normalization of catalase activity in the testis, which correlated with a decrease in the amount of TBA-reacting products and activity of superoxide dismutase and catalase in the blood plasma of animals; the use of NSE also contributed to the reduction of nitrite content in the gonads and to normalization of both nitrite and nitrate in the blood plasma of rats. Nitrites 461-468 enolase 2 Rattus norvegicus 33-36 22094978-6 2012 The ratio of dissolved oxygen to ammonium loading rate (DO/ALR) was critical to maintain high ammonium removal efficiency and nitrite accumulation ratio. Nitrites 126-133 growth factor, augmenter of liver regeneration Homo sapiens 59-62 22480334-7 2012 Int-2, which was generated and characterized independently, is an analog of the electrophilic intermediates in the mechanism of biological reduction of nitrite to ( )NO. Nitrites 152-159 fibroblast growth factor 3 Homo sapiens 0-5 22480334-8 2012 Excess nitrite greatly reduces the lifetime of Int-1, which under such conditions decomposes on a millisecond time scale by nitrite-catalyzed disproportionation to yield L(2)(H(2)O)RhNO(2+) and L(2)Rh(III). Nitrites 7-14 Wnt family member 1 Homo sapiens 47-52 22480334-8 2012 Excess nitrite greatly reduces the lifetime of Int-1, which under such conditions decomposes on a millisecond time scale by nitrite-catalyzed disproportionation to yield L(2)(H(2)O)RhNO(2+) and L(2)Rh(III). Nitrites 124-131 Wnt family member 1 Homo sapiens 47-52 22094978-7 2012 Over 85% of nitrite accumulation ratio and more than 95% of ammonium removal efficiency were achieved at DO/ALR ratios in an optimal range of 4.0-6.0 mg O(2)/g N d, even under the disturbances of ammonium loading rate. Nitrites 12-19 growth factor, augmenter of liver regeneration Homo sapiens 108-111 22154098-5 2012 The embedded proteins also retain their bio-catalytical activity for hydrogen peroxide and nitrite reduction with linear ranges of 0.5-3000 muM and 30-150 muM, sensitivities of 73.6+-0.6nA muM(-1) and 5.72+-0.11 nA muM(-1), and detection limits close to 0.08 muM and 5.80 muM, for these two analytes respectively. Nitrites 91-98 PWWP domain containing 3A, DNA repair factor Homo sapiens 189-195 22154098-5 2012 The embedded proteins also retain their bio-catalytical activity for hydrogen peroxide and nitrite reduction with linear ranges of 0.5-3000 muM and 30-150 muM, sensitivities of 73.6+-0.6nA muM(-1) and 5.72+-0.11 nA muM(-1), and detection limits close to 0.08 muM and 5.80 muM, for these two analytes respectively. Nitrites 91-98 PWWP domain containing 3A, DNA repair factor Homo sapiens 215-221 22304432-5 2012 Multiple NOS isoforms are necessary for FGF2-mediated cardioprotection, and nitrite levels are significantly reduced in FGF2 Tg hearts upon inhibition of protein kinase C or mitogen-activated protein kinases. Nitrites 76-83 fibroblast growth factor 2 Homo sapiens 120-124 22364946-5 2012 In contrast, IRAK-1 deficient mice had significantly lower lipid peroxidation and nitrite levels, as well as lower levels of pro-inflammatory mediators. Nitrites 82-89 interleukin-1 receptor-associated kinase 1 Mus musculus 13-19 23576844-7 2012 Mb in the films displayed good electrocatalytic activities towards various substrates such as hydrogen peroxide, nitrite and oxygen, indicating that the composite films have potential applications in fabricating novel biosensors without using mediators. Nitrites 113-120 myoglobin Homo sapiens 0-2 22184419-5 2012 In the presence of copper, the copA mutant exhibited increased sensitivity to killing by nitrite or nitric oxide. Nitrites 89-96 COPI coat complex subunit alpha Homo sapiens 31-35 22192332-8 2012 RESULTS: High plasma levels of nitrite and nitrate (No2-/No3-) were observed in critically ill patients (mean level 78.92 mumol/l in sepsis and 97.20 mumol/l in septic shock). Nitrites 31-38 NBL1, DAN family BMP antagonist Homo sapiens 57-60 21954917-4 2012 Treatment with the HO-1 inducer CoPP (cobalt protoporphyrin IX) counteracted the stimulatory effects of IL-1beta on IL-6, nitrite, PGE2 (prostaglandin E2), TGF (transforming growth factor) beta2, TGFbeta3 and osteocalcin. Nitrites 122-129 heme oxygenase 1 Homo sapiens 19-23 21954917-4 2012 Treatment with the HO-1 inducer CoPP (cobalt protoporphyrin IX) counteracted the stimulatory effects of IL-1beta on IL-6, nitrite, PGE2 (prostaglandin E2), TGF (transforming growth factor) beta2, TGFbeta3 and osteocalcin. Nitrites 122-129 interleukin 1 beta Homo sapiens 104-112 24956513-5 2012 Stimulation with TGFbeta and dynamic compression reduced nitrite release and increased matrix synthesis and gene expression of aggrecan and collagen type II. Nitrites 57-64 transforming growth factor beta 1 Homo sapiens 17-24 22434701-3 2012 The products of nitrite (NO(2) (-) ) oxidation by salivary peroxidase (SPO) and commercial bovine lactoperoxidase (LPO) are studied by utilizing an electrochemical assay that allows the direct, continuous monitoring of NO and/or NO(2) and by HPLC to assess nitrates at the end of the reaction. Nitrites 16-23 lactoperoxidase Homo sapiens 50-69 22434701-3 2012 The products of nitrite (NO(2) (-) ) oxidation by salivary peroxidase (SPO) and commercial bovine lactoperoxidase (LPO) are studied by utilizing an electrochemical assay that allows the direct, continuous monitoring of NO and/or NO(2) and by HPLC to assess nitrates at the end of the reaction. Nitrites 16-23 lactoperoxidase Bos taurus 98-113 22434701-3 2012 The products of nitrite (NO(2) (-) ) oxidation by salivary peroxidase (SPO) and commercial bovine lactoperoxidase (LPO) are studied by utilizing an electrochemical assay that allows the direct, continuous monitoring of NO and/or NO(2) and by HPLC to assess nitrates at the end of the reaction. Nitrites 16-23 lactoperoxidase Bos taurus 115-118 22434701-4 2012 Dialyzed saliva and LPO, in the presence of H(2) O(2) , convert nitrite into nitrate and form some NO, with a molar ratio of 10(3) . Nitrites 64-71 lactoperoxidase Bos taurus 20-23 22308405-7 2012 In vitro nitration of Lba with excess nitrite produced several isomers of nitrated heme, one of which is identical to those found in vivo. Nitrites 38-45 leghemoglobin A Glycine max 22-25 22178413-5 2012 We show that leukocyte emigration in response to the proinflammatory chemokine MIP-2 is reduced by 70% after 7 days of dietary nitrate supplementation as well as by acute intravenous nitrite administration. Nitrites 183-190 C-X-C motif chemokine ligand 2 Rattus norvegicus 79-84 22178413-7 2012 Further studies in TNF-alpha-stimulated endothelial cells revealed that nitrite dose-dependently reduced the expression of ICAM-1. Nitrites 72-79 tumor necrosis factor Rattus norvegicus 19-28 22178413-7 2012 Further studies in TNF-alpha-stimulated endothelial cells revealed that nitrite dose-dependently reduced the expression of ICAM-1. Nitrites 72-79 intercellular adhesion molecule 1 Rattus norvegicus 123-129 22224438-6 2012 A salivary component SCN(-) (1 mM) enhanced and suppressed NO production induced by 1 mM nitrite when sulfite concentrations were lower and higher than 1 mM, respectively. Nitrites 89-96 sorcin Homo sapiens 21-33 24273688-8 2012 The absence of caveolin-1 resulted in increased nitrite levels in the lavage fluid in both sham and LPS treated mice. Nitrites 48-55 caveolin 1, caveolae protein Mus musculus 15-25 22038823-8 2012 Inhibition of Akt signaling with LY294002 or a dominant negative Akt plasmid increased cytokine-stimulated nitrite production and iNOS protein expression and blocked the inhibitory effects of insulin. Nitrites 107-114 AKT serine/threonine kinase 1 Rattus norvegicus 14-17 22038823-8 2012 Inhibition of Akt signaling with LY294002 or a dominant negative Akt plasmid increased cytokine-stimulated nitrite production and iNOS protein expression and blocked the inhibitory effects of insulin. Nitrites 107-114 AKT serine/threonine kinase 1 Rattus norvegicus 65-68 22541370-4 2012 We demonstrate that Mygalin induces IFN-gamma synthesis by splenocytes increasing the nitrite secretion by splenocytes and macrophages. Nitrites 86-93 interferon gamma Mus musculus 36-45 22399419-5 2012 The reaction of NO with cytochrome c oxidase (CcOX) directly involves the active site of the enzyme: two mechanisms have been described leading to formation of either a relatively stable nitrosyl-derivative (CcOX-NO) or a more labile nitrite-derivative (CcOX-NO (2) (-) ). Nitrites 234-241 cytochrome c, somatic Homo sapiens 24-36 22498469-1 2012 Gold dendrites (AuD) were synthesized with egg white as the soft template and a novel nitrite (NO(2)(-)) biosensor was fabricated by assembly of a myoglobin (Mb)-L-cysteamine (Cys)-AuD biological hybrid. Nitrites 86-93 myoglobin Homo sapiens 147-156 22498469-1 2012 Gold dendrites (AuD) were synthesized with egg white as the soft template and a novel nitrite (NO(2)(-)) biosensor was fabricated by assembly of a myoglobin (Mb)-L-cysteamine (Cys)-AuD biological hybrid. Nitrites 86-93 myoglobin Homo sapiens 158-160 22036766-8 2012 TNF-alpha-toxicity led to significant increase in myeloperoxidase (MPO, an index of neutrophils infiltration), nitrites (stable nitric oxide metabolites) and malondialdehyde (MDA, a marker of lipid peroxides) levels and cell apoptosis in liver and colon. Nitrites 111-119 tumor necrosis factor Mus musculus 0-9 22124705-1 2012 The aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric arteries. Nitrites 69-76 monoamine oxidase A Homo sapiens 163-168 22124705-1 2012 The aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric arteries. Nitrites 69-76 monoamine oxidase B Homo sapiens 173-178 22124705-1 2012 The aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric arteries. Nitrites 69-76 amine oxidase copper containing 2 Homo sapiens 184-221 22124705-1 2012 The aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric arteries. Nitrites 69-76 amine oxidase copper containing 2 Homo sapiens 223-227 22721505-7 2012 All these effects of TNF- alpha/CHX were partially prevented by pretreatment with a carbon monoxide-releasing agent (CORM-A1) and nitrite. Nitrites 130-137 tumor necrosis factor Mus musculus 21-31 22170613-8 2012 The estimated LODs for nitrite and nitrate in ninefold diluted plasma sample were 0.05 and 0.07 muM, respectively. Nitrites 23-30 latexin Homo sapiens 96-99 22170613-9 2012 The LODs for nitrite and nitrate in original plasma samples were 0.45 and 0.63 muM. Nitrites 13-20 latexin Homo sapiens 79-82 22675382-7 2012 CE and F80 promoted a reduction of the leukocyte number and nitrite level in inflammatory exudates when the anti-inflammatory assay (carrageenan-induced peritonitis) was performed. Nitrites 60-67 zinc finger protein 120 Mus musculus 7-10 22848212-11 2012 Suppression of NFkappaB activity was ameliorated in macrophages cultured with IFN-gamma and this correlated with increased expression of iNOS mRNA and nitrite ion production, although IFN-gamma had no effect on AP-1/DNA interaction. Nitrites 151-158 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 15-23 22848212-11 2012 Suppression of NFkappaB activity was ameliorated in macrophages cultured with IFN-gamma and this correlated with increased expression of iNOS mRNA and nitrite ion production, although IFN-gamma had no effect on AP-1/DNA interaction. Nitrites 151-158 interferon gamma Mus musculus 78-87 22848212-14 2012 S. typhimurium inhibit NFkappaB and AP-1 interaction with macrophage DNA via the PhoP regulon, this reduces nitrite ion production and is principally associated with typhoidal serovars. Nitrites 108-115 jun proto-oncogene Mus musculus 36-40 21956669-2 2012 Because interethnic differences exist with respect to risk factors, prevalence, and severity of cardiovascular diseases, we designed this study to examine whether the circulating levels of nitrites (a marker of endogenous NO formation) are associated with the plasma levels of MMP-9 and MMP-2 in healthy black subjects. Nitrites 189-197 matrix metallopeptidase 9 Homo sapiens 277-282 22496969-5 2012 Univariate regressions showed that changes in urinary sodium/potassium ratio (beta = 1.99) and plasma renin activity (beta = -15.78) and percent change in plasma nitrite after hyperemia were associated with SBP changes at week one (all P < 0.05). Nitrites 162-169 selenium binding protein 1 Homo sapiens 207-210 22530108-4 2012 Liver AST and LDH release were significantly reduced in both nitrite-supplemented LR and UW preservation solutions compared to their controls. Nitrites 61-68 solute carrier family 17 member 5 Homo sapiens 6-9 21956669-2 2012 Because interethnic differences exist with respect to risk factors, prevalence, and severity of cardiovascular diseases, we designed this study to examine whether the circulating levels of nitrites (a marker of endogenous NO formation) are associated with the plasma levels of MMP-9 and MMP-2 in healthy black subjects. Nitrites 189-197 matrix metallopeptidase 2 Homo sapiens 287-292 21956669-7 2012 Interestingly, we found a negative relationship between the plasma MMP-9 levels and the plasma or whole blood nitrites levels (P = 0.04, rs = -0.149; and P < 0.0001, rs = -0.349, respectively). Nitrites 110-118 matrix metallopeptidase 9 Homo sapiens 67-72 21956669-8 2012 In parallel, we found similar negative relationships between plasma MMP-2 levels and plasma or whole blood nitrites levels (P = 0.02, rs = -0.172; and P < 0.0001, rs = -0.454, respectively). Nitrites 107-115 matrix metallopeptidase 2 Homo sapiens 68-73 22197744-4 2012 We observed that, nitrite significantly attenuates hypoxia-induced oxidative stress, modulates HIF-1alpha stability and promotes NO-cGMP signaling in hypoxic heart. Nitrites 18-25 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 95-105 22276188-8 2012 Furthermore, deoxygenation enhanced the effect of nitrite as observed from a decrease of P-selectin expression and increase of the cGMP levels in platelets. Nitrites 50-57 selectin P Homo sapiens 89-99 23251721-7 2012 Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. Nitrites 0-7 microcephaly, primary autosomal recessive 1 Mus musculus 119-122 22363694-4 2012 In marked contrast, the expressions of both mRNA and protein levels of inducible nitrate oxide synthase (iNOS) increased, and were accompanied by increased extracellular nitrate/nitrite production by Griess reaction. Nitrites 178-185 nitric oxide synthase 2 Homo sapiens 71-103 22363694-4 2012 In marked contrast, the expressions of both mRNA and protein levels of inducible nitrate oxide synthase (iNOS) increased, and were accompanied by increased extracellular nitrate/nitrite production by Griess reaction. Nitrites 178-185 nitric oxide synthase 2 Homo sapiens 105-109 22583316-5 2012 Lp-PLA2 levels were found to be positively correlated with arginase, triglycerides, total cholesterol, low-density lipoprotein-cholesterol, and age and negatively correlated with high-density lipoprotein-cholesterol and total nitrite levels, while there was no correlation with BMI and hs-CRP, albumin, and creatinine levels in HD patients. Nitrites 226-233 phospholipase A2 group VII Homo sapiens 0-7 22319612-3 2012 Inhibiting Akt phosphorylation or immunoprecipitating adiponectin (found in high quantities in CR serum) completely prevented the increment in nitrite release and eNOS activation. Nitrites 143-150 AKT serine/threonine kinase 1 Rattus norvegicus 11-14 22319612-3 2012 Inhibiting Akt phosphorylation or immunoprecipitating adiponectin (found in high quantities in CR serum) completely prevented the increment in nitrite release and eNOS activation. Nitrites 143-150 adiponectin, C1Q and collagen domain containing Rattus norvegicus 54-65 21965683-0 2011 14-3-3 binding and phosphorylation of neuroglobin during hypoxia modulate six-to-five heme pocket coordination and rate of nitrite reduction to nitric oxide. Nitrites 123-130 neuroglobin Homo sapiens 38-49 22021929-0 2011 Nitrite-mediated S-nitrosylation of caspase-3 prevents hypoxia-induced endothelial barrier dysfunction. Nitrites 0-7 caspase 3 Homo sapiens 36-45 22021929-5 2011 Nitrite treatment led to S-nitrosylation and the inactivation of caspase-3, suppressing the barrier dysfunction of endothelia caused by hypoxia. Nitrites 0-7 caspase 3 Homo sapiens 65-74 22021929-7 2011 Using primary human umbilical vein endothelial cells as a model, we showed that in the presence of nitrite, the S-nitrosylated and inactivated form of caspase-3 was unable to cleave beta-catenin, a key component in the VE-cadherin complex. Nitrites 99-106 caspase 3 Homo sapiens 151-160 22021929-7 2011 Using primary human umbilical vein endothelial cells as a model, we showed that in the presence of nitrite, the S-nitrosylated and inactivated form of caspase-3 was unable to cleave beta-catenin, a key component in the VE-cadherin complex. Nitrites 99-106 cadherin 5 Homo sapiens 219-230 22021929-8 2011 Therefore, nitrite treatment led to the maintenance of VE-cadherin-mediated adherens junctions under hypoxic conditions. Nitrites 11-18 cadherin 5 Homo sapiens 55-66 21965683-4 2011 Recent studies have shown that post-translational redox regulation of neuroglobin surface thiol disulfide formation increases the open probability of the heme pocket and allows nitrite binding and reaction to form NO. Nitrites 177-184 neuroglobin Homo sapiens 70-81 21912778-6 2011 Linear response was obtained in the range of 0.5-722 muM with a detection limit of 0.1 muM (S/N = 3) for nitrite determination. Nitrites 105-112 latexin Homo sapiens 53-56 21649641-4 2011 iNOS expression was determined by nitrite assays on culture medium removed from treated cells and by immunoblotting of cell protein extracts. Nitrites 34-41 nitric oxide synthase 2 Rattus norvegicus 0-4 20531373-0 2011 Endothelial nitric oxide synthase gene haplotypes affect nitrite levels in black subjects. Nitrites 57-64 nitric oxide synthase 3 Homo sapiens 0-33 21912778-6 2011 Linear response was obtained in the range of 0.5-722 muM with a detection limit of 0.1 muM (S/N = 3) for nitrite determination. Nitrites 105-112 latexin Homo sapiens 87-90 21986532-5 2011 eNOS activity was determined by nitrite/nitrate accumulation, either via a fluorometric assay or by(15)N-nitrite or estimated (15)N(3)-citrulline concentrations when (15)N(4)-ARG was used to challenge the cells. Nitrites 32-39 nitric oxide synthase 3 Homo sapiens 0-4 22081021-4 2011 Administration of nitrite, which can be converted into NO in vivo, rescued the manifestations of NO deficiency in hypomorphic Asl mice, and a nitric oxide synthase (NOS)-independent NO donor restored NO-dependent vascular reactivity in humans with ASL deficiency. Nitrites 18-25 argininosuccinate lyase Mus musculus 126-129 21822146-5 2011 Increasing nitrite availability resulted in increased Th-SNO formation for all drugs (other than ticlopidine). Nitrites 11-18 strawberry notch homolog 1 Homo sapiens 57-60 21986532-8 2011 Reduced (15)N(4)-ARG cellular uptake in CAT-1 siRNA transfected cells vs. control was accompanied by reduced eNOS activity, as determined by (15)N-nitrite, total nitrite and (15)N(3)-citrulline formation. Nitrites 147-154 transient receptor potential cation channel subfamily V member 6 Homo sapiens 40-45 21729740-7 2011 Concomitantly, NF-kappaB DNA binding activity and the mRNA and protein expression levels of NF-kappaB/p65, Notch-1, intracellular domain of Notch-1 receptor (NICD), Hes-1, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) along with nitrite level were significantly reduced. Nitrites 297-304 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 15-24 22320098-1 2011 A reusable catalytic reductor consisting of 96 copperized-cadmium pins attached to a microplate lid was developed to simultaneously reduce nitrate (NO3-) to nitrite (NO2-) in all wells of a standard microplate. Nitrites 157-164 NBL1, DAN family BMP antagonist Homo sapiens 148-151 21722713-13 2011 Prior chronic exercise suppressed KA-induced hippocampal neuronal death in hippocampal CA3 region in restrained mice via declined ROS levels, which was lower MDA and nitrite levels, and activation of CREB, which was mediated by ERK1/2 and CaMKII, suggesting that chronic exercise exerts a protective effect on excitatory neurodegenerative disorders including epileptic seizure. Nitrites 166-173 carbonic anhydrase 3 Mus musculus 87-90 21499737-4 2011 Salvinorin A (0.1-10 pM) reduced LPS-stimulated nitrite, TNF-alpha and IL-10 (but not IL-1beta) levels as well as iNOS (but not COX-2) LPS-induced hyperexpression. Nitrites 48-55 toll-like receptor 4 Mus musculus 33-36 21975817-5 2011 In addition, treatment with SnPP (tin protoporphyrin IX), a selective HO-1 inhibitor, counteracted the inhibitory effect of EG on nitrite production, suggesting that HO-1 is, at least in part, implicated in the inhibition of NO production induced by EG treatment. Nitrites 130-137 heme oxygenase 1 Homo sapiens 166-170 21499737-5 2011 The effect of salvinorin A on nitrite levels was reverted by the opioid antagonist naloxone, the KOR antagonist nor-binaltorphimine and by the CB1 antagonist rimonabant Salvinorin A also prevented KOR and CB1 hyperexpression induced by LPS. Nitrites 30-37 opioid receptor, kappa 1 Mus musculus 97-100 21499737-5 2011 The effect of salvinorin A on nitrite levels was reverted by the opioid antagonist naloxone, the KOR antagonist nor-binaltorphimine and by the CB1 antagonist rimonabant Salvinorin A also prevented KOR and CB1 hyperexpression induced by LPS. Nitrites 30-37 cannabinoid receptor 1 (brain) Mus musculus 143-146 21543107-1 2011 INTRODUCTION: Despite experimental evidences of the influence of the aging suppressor gene Klotho, on the modulation of endothelial nitric oxide synthase (eNOS) activity and nitric oxide (NO) production, the contribution of its variants to the phenotypic variance of plasma nitrite and nitrate (NO(x)) has not been addressed to date. Nitrites 274-281 klotho Homo sapiens 91-97 21531147-5 2011 The NFkappaB-iNOS pathway was analyzed by a SEAP reporter gene assay, Western-blotting and nitrite measurements. Nitrites 91-98 nitric oxide synthase 2 Rattus norvegicus 13-17 21744811-1 2011 The role of NO and nitrite-bound methemoglobin (Hb(III)NO(2)(-)) in hypoxic signaling is highly controversial. Nitrites 19-26 hemoglobin subunit gamma 2 Homo sapiens 33-46 21554376-9 2011 Levels of nitrite and nitrate (NO(x)), as an index of nitric oxide, bioavailability were significantly decreased in the iNOS(-/-) diabetic mouse heart. Nitrites 10-17 nitric oxide synthase 2, inducible Mus musculus 120-124 21733982-2 2011 In the present study, nitrated alpha-synuclein with four 3-nitrotyrosines (Tyr(39), Tyr(125), Tyr(133), and Tyr(136)) was obtained non-enzymatically by incubation with nitrite. Nitrites 168-175 synuclein alpha Homo sapiens 31-46 21708390-4 2011 Phosphate levels were abnormally high varying between 4.35 and 130.82 muM, whereas nitrate and nitrite ranged from 0.06 to 54.05 muM and from 0.28 to 19.23 muM, respectively. Nitrites 95-102 latexin Homo sapiens 129-132 21708390-4 2011 Phosphate levels were abnormally high varying between 4.35 and 130.82 muM, whereas nitrate and nitrite ranged from 0.06 to 54.05 muM and from 0.28 to 19.23 muM, respectively. Nitrites 95-102 latexin Homo sapiens 129-132 21490139-9 2011 Finally, COS7 cells expressing NOS1alpha or NOS1alpha/DNM2-GFP had significantly higher nitrite production compared with DNM2-GFP only. Nitrites 88-95 dynamin 2 Rattus norvegicus 54-58 21556719-12 2011 Urinary MMP-9/NGAL/Cr level was also correlated with positive urine nitrite test, positive urine leukocyte esterase reaction and renal scarring (p = 0.0001, p = 0.0001, p = 0.04, respectively) whereas was not correlated to leukocytosis and positive CRP level in serum. Nitrites 68-75 matrix metallopeptidase 9 Homo sapiens 8-13 21556719-12 2011 Urinary MMP-9/NGAL/Cr level was also correlated with positive urine nitrite test, positive urine leukocyte esterase reaction and renal scarring (p = 0.0001, p = 0.0001, p = 0.04, respectively) whereas was not correlated to leukocytosis and positive CRP level in serum. Nitrites 68-75 lipocalin 2 Homo sapiens 14-18 21490139-10 2011 Nitrite production was blocked by the DNM inhibitor dynasore or the dominant negative DNM2K44A. Nitrites 0-7 dynamin 1 Rattus norvegicus 38-41 21490139-11 2011 Ionomycin stimulation further increased nitrite production in the NOS1alpha/DNM2-GFP cells compared with NOS1alpha only. Nitrites 40-47 dynamin 2 Rattus norvegicus 76-80 21424691-5 2011 Genetic and biochemical analyses identified the essential nitrate/nitrite assimilation functions of the encoded proteins, orderly, the assimilatory nitrate reductase catalytic subunit (NasA), nitrate reductase electron transfer subunit (NasC), nitrate/nitrite transporter (NasK), assimilatory nitrite reductase large subunit (NasB) and small subunit (NasD), bifunctional uroporphyrinogen-III synthase (NasE), and an unknown function protein (NasF). Nitrites 66-73 uroporphyrinogen-III synthase Amycolatopsis mediterranei U32 371-400 21491030-0 2011 Determination of nitrite in tap waters based on fluorosurfactant-capped gold nanoparticles-enhanced chemiluminescence from carbonate and peroxynitrous acid. Nitrites 17-24 nuclear RNA export factor 1 Homo sapiens 28-31 21228891-9 2011 Our results suggest that the AOA, not the AOB, were contributing to nitrate leaching at the site by providing substrate for the nitrite oxidizers. Nitrites 128-135 aprataxin Homo sapiens 29-32 21510821-9 2011 Nitrite production, GAG expression, and GFP-TAT transduction were significantly attenuated by inhibitors of JNK, p38, or ERK. Nitrites 0-7 mitogen-activated protein kinase 8 Homo sapiens 108-111 21510821-9 2011 Nitrite production, GAG expression, and GFP-TAT transduction were significantly attenuated by inhibitors of JNK, p38, or ERK. Nitrites 0-7 mitogen-activated protein kinase 14 Homo sapiens 113-116 21510821-9 2011 Nitrite production, GAG expression, and GFP-TAT transduction were significantly attenuated by inhibitors of JNK, p38, or ERK. Nitrites 0-7 mitogen-activated protein kinase 1 Homo sapiens 121-124 21712817-5 2011 We show that activation of TRPV3, a heat-activated transient receptor potential ion channel expressed in keratinocytes, induces NO production via a nitrite-dependent pathway. Nitrites 148-155 transient receptor potential cation channel subfamily V member 3 Homo sapiens 27-32 21491030-7 2011 This method has been successfully applied to determine nitrite in tap waters with recoveries of 97-106%. Nitrites 55-62 nuclear RNA export factor 1 Homo sapiens 66-69 21205219-8 2011 In response to CCT diet, a decrease in serum insulin, alpha-amylase activity, hepatic glycogen, pancreatic calcium with a concomitant increase in serum glucose, lipid profile (except high-density lipoprotein cholesterol (HDL-C)), pancreatic nitrite and lipid peroxidation and the size of adipocytes along with macrophages infiltration were observed. Nitrites 241-248 FLVCR heme transporter 2 Rattus norvegicus 15-18 21411497-11 2011 Indeed proliferative effect of nitrite was blocked by roscovitine, a Cdk2 inhibitor. Nitrites 31-38 cyclin dependent kinase 2 Homo sapiens 69-73 21657847-1 2011 AIMS: Elevation of the leukocyte enzyme myeloperoxidase (MPO) in stable coronary artery disease (CAD) is controversial and its relationship with oxidized low-density lipoprotein (ox-LDL) and nitrite/nitrate (NOx) levels in CAD patients has not been evaluated. Nitrites 191-198 myeloperoxidase Homo sapiens 40-55 21657847-1 2011 AIMS: Elevation of the leukocyte enzyme myeloperoxidase (MPO) in stable coronary artery disease (CAD) is controversial and its relationship with oxidized low-density lipoprotein (ox-LDL) and nitrite/nitrate (NOx) levels in CAD patients has not been evaluated. Nitrites 191-198 myeloperoxidase Homo sapiens 57-60 21334141-7 2011 BBS-2 significantly reduced the increases in lung lymph nitrite/nitrate (10 +- 3 muM vs. 26 +- 6 muM in controls, p < 0.05) and 3-nitrotyrosine (109 +- 11 (densitometry value) vs. 151 +- 18 in controls, p < 0.05). Nitrites 56-63 Bardet-Biedl syndrome 2 protein Ovis aries 0-5 21411497-0 2011 Nitrite-mediated modulation of HL-60 cell cycle and proliferation: involvement of cyclin-dependent kinase 2 activation. Nitrites 0-7 cyclin dependent kinase 2 Homo sapiens 82-107 21411497-12 2011 The results obtained demonstrate that the proliferative effect of nitrite on HL-60 cells seems to be NO-mediated, redox-sensitive, and Cdk2 activation-dependent, warranting detailed studies before initiating its clinical use. Nitrites 66-73 cyclin dependent kinase 2 Homo sapiens 135-139 21590821-5 2011 Although N(2)O(3) formation might be readily explained by the reaction Hb-Fe(3+)+NO(2)(-)+NO Hb-Fe(2+)+N(2)O(3), the exact manner in which methemoglobin (Hb-Fe(3+)), nitrite and NO interact with one another is unclear. Nitrites 166-173 hemoglobin subunit gamma 2 Homo sapiens 139-152 21440656-3 2011 cis-[Ru(bpy)2(py)NO2](PF6) (RuBPY) is a new nitrite complex synthesized in our laboratory that releases NO in the presence of the vascular tissue only. Nitrites 44-51 sperm associated antigen 17 Homo sapiens 22-25 21439356-8 2011 Rofecoxib (5 and 10mg/kg), caffeic acid (5 and 10mg/kg), Gal (2.5 and 5mg/kg) treatment for 14 days significantly improved locomotor activity, memory retention and oxidative defense (as evidenced by decrease lipid peroxidation, nitrite, increased superoxide dismutase activity and redox ratio) in hippocampus. Nitrites 228-235 galanin and GMAP prepropeptide Rattus norvegicus 57-60 21584187-3 2011 Ferredoxin-nitrite reductase (NiR) catalyses the reduction of nitrite to ammonium in the second step of the nitrate- assimilation pathway. Nitrites 11-18 nitrite reductase 1 Arabidopsis thaliana 30-33 21296891-3 2011 We show that deoxygenated human neuroglobin reacts with nitrite to form nitric oxide (NO). Nitrites 56-63 neuroglobin Homo sapiens 32-43 21296891-5 2011 Replacement of the distal histidine by leucine or glutamine leads to a stable five-coordinated geometry; these neuroglobin mutants reduce nitrite to NO ~2000 times faster than the wild type, whereas mutation of either Cys-55 or Cys-46 to alanine stabilizes the six-coordinate structure and slows the reaction. Nitrites 138-145 neuroglobin Homo sapiens 111-122 20518849-7 2011 Intact MLC1 levels, measured by 2D gel electrophoresis and immunoblot, were shown to decrease with increasing duration of ischemia, which correlated with increasing levels of nitrotyrosine and nitrite/nitrate. Nitrites 193-200 myosin light chain 1 Homo sapiens 7-11 21193899-6 2011 Inducible nitric oxide synthase (iNOS) levels decreased in association with reduced islet-derived nitrite levels. Nitrites 98-105 nitric oxide synthase 2 Homo sapiens 0-31 21193899-6 2011 Inducible nitric oxide synthase (iNOS) levels decreased in association with reduced islet-derived nitrite levels. Nitrites 98-105 nitric oxide synthase 2 Homo sapiens 33-37 21329685-5 2011 Moreover the two highest concentrations of both fluoride-containing bioglasses and NaF caused increase of nitrite (a stable derivative of NO) levels in the culture supernatant, which was inhibited by l-NMMA, erythrocytes, PTIO and SOD/catalase, and increase of intracellular NO synthase (NOS) activity. Nitrites 106-113 C-X-C motif chemokine ligand 8 Homo sapiens 83-86 21329685-5 2011 Moreover the two highest concentrations of both fluoride-containing bioglasses and NaF caused increase of nitrite (a stable derivative of NO) levels in the culture supernatant, which was inhibited by l-NMMA, erythrocytes, PTIO and SOD/catalase, and increase of intracellular NO synthase (NOS) activity. Nitrites 106-113 nitric oxide synthase 2 Homo sapiens 275-286 21344112-2 2011 The structures show that the salen ligand coordinates to the four equatorial sites of the metal ion and the formate or nitrite ions coordinate to the axial positions to bridge the Mn(III)-salen units through a syn-antimu-1kappaO:2kappaO" coordination mode. Nitrites 119-126 synemin Homo sapiens 210-213 21331487-0 2011 Development of a new three-phase membrane-assisted liquid-phase microextraction method: determination of nitrite in tap water samples as model analytical application. Nitrites 105-112 nuclear RNA export factor 1 Homo sapiens 116-119 21382015-10 2011 In astrocytes, BG-12 increased HO-1 mRNA levels and effects on nitrite levels were blocked by an HO-1 inhibitor. Nitrites 63-70 heme oxygenase 1 Homo sapiens 97-101 21331487-4 2011 The device has been tested for the determination of nitrite in tap water samples, which is extensively carried out in routine analysis, as model analytical application. Nitrites 52-59 nuclear RNA export factor 1 Homo sapiens 63-66 21256669-14 2011 Irrigation with tap water significantly lowered the incidence of nitrite-positive study days and was substantially less costly and more patient friendly than NaCl irrigation. Nitrites 65-72 nuclear RNA export factor 1 Homo sapiens 16-19 21436578-3 2011 In this issue of the JCI, Alef and colleagues provide evidence that in the injured vessel wall, the disruption of the NOS pathway is countered by induction of xanthine oxidoreductase, an enzyme capable of producing NO from nitrite. Nitrites 223-230 xanthine dehydrogenase Mus musculus 159-182 21094119-5 2011 Nitrite (NO(2)(-)) was found to be an uncompetitive inhibitor of heCAT activity (IC(50)=9 muM) and of CAT activity in hemolysate (IC(50)~750 muM). Nitrites 0-7 catalase Homo sapiens 67-70 21436585-6 2011 Additionally, nitrite led to the generation of NO in vessels and SMCs, as well as limited SMC proliferation via p21Waf1/Cip1 signaling. Nitrites 14-21 cyclin-dependent kinase inhibitor 1A Rattus norvegicus 120-124 21436585-11 2011 The vasoprotective effects of nitrite were counteracted by inhibition of XOR. Nitrites 30-37 xanthine dehydrogenase Rattus norvegicus 73-76 20817308-12 2011 The Balb/Xid mice also presented a proinflammatory profile of TNF-alpha, IL-6 and nitrite, as well as lower levels of IL-10. Nitrites 82-89 Bruton agammaglobulinemia tyrosine kinase Mus musculus 9-12 21193589-5 2011 The expression of inducible nitric oxide (NO) synthase (iNOS) mRNA was increased in the vascular tissues isolated from BDL rats, and accordingly, nitrate/nitrite production was increased. Nitrites 154-161 nitric oxide synthase 2 Rattus norvegicus 56-60 20839220-12 2011 The underlying mechanisms could be their autoxidation, exposure to either visible or UV light, interaction with nitrite or transition metals to form reactive intermediates, serving as ligands to interact with an AhR that is known to play a role in carcinogenesis through induction of XMEs. Nitrites 112-119 aryl hydrocarbon receptor Homo sapiens 212-215 20938379-12 2011 Significant decreases in plasma nitrate/nitrite after injury were associated with increased lung ADMA concentrations and decreased DDAH-2 expression. Nitrites 40-47 dimethylarginine dimethylaminohydrolase 2 Homo sapiens 131-137 21304405-7 2011 In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model. Nitrites 118-125 interleukin 2 Mus musculus 20-24 21304405-7 2011 In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model. Nitrites 118-125 interleukin 2 Mus musculus 89-93 21304405-7 2011 In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model. Nitrites 118-125 interleukin 2 Mus musculus 89-93 21055386-0 2011 The cytochrome c8 involved in the nitrite reduction pathway acts also as electron donor to the photosynthetic reaction center in Rubrivivax gelatinosus. Nitrites 34-41 cytochrome c, somatic Homo sapiens 4-16 21177703-8 2011 Multiple nitrite reductases have been shown to be relevant in the conversion of nitrite to metabolically active NO, including deoxy-haemoglobin and myoglobin in the circulation and heart, respectively, and xanthine oxidoreductase in the lung parenchyma. Nitrites 9-16 xanthine dehydrogenase Homo sapiens 206-229 20889759-0 2011 The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Nitrites 34-41 myoglobin Mus musculus 21-30 20889759-1 2011 AIMS: This work investigates the role of myoglobin in mediating the vascular relaxation induced by nitrite. Nitrites 99-106 myoglobin Mus musculus 41-50 20889759-5 2011 The current study was designed to confirm the presence of myoglobin in murine aortic tissue and to test the hypothesis that vascular wall myoglobin is important for nitrite-induced vasodilation. Nitrites 165-172 myoglobin Mus musculus 138-147 20889759-8 2011 Restitution of myoglobin using a genetically modified adenovirus both increased vasodilation to nitrite and reinstated the wild-type pattern of response to CO. Nitrites 96-103 myoglobin Mus musculus 15-24 20889759-9 2011 CONCLUSION: Myoglobin is present in the murine vasculature and contributes significantly to nitrite-induced vasodilation. Nitrites 92-99 myoglobin Mus musculus 12-21 20348208-9 2011 LPS-treated SP-A(-/-) mice, however, had elevated nitrite concentrations, inducible nitric oxide synthase (iNOS) expression, and NOS activity in their lungs. Nitrites 50-57 surfactant associated protein A1 Mus musculus 12-16 21183258-2 2011 Compounds 12, 17, 24 and 26 were found to decrease nitrite levels in a dose-dependent manner in LPS-activated cells. Nitrites 51-58 toll-like receptor 4 Mus musculus 96-99 21183258-4 2011 Interestingly, compound 27 which contains nitroxide free radical was the most active compound in this series showing 59.2% nitrite inhibition in LPS-activated macrophage cells. Nitrites 123-130 toll-like receptor 4 Mus musculus 145-148 20974700-3 2011 When salbutamol was exposed to myeloperoxidase, eosinophil peroxidase or lactoperoxidase in the presence of hydrogen peroxide (H(2)O(2)) and nitrite (NO(2)(-)), both absorption spectroscopy and mass spectrometry indicated formation of a new metabolite with features expected for the nitrated drug. Nitrites 141-148 eosinophil peroxidase Homo sapiens 48-69 21267455-6 2011 Cell elongation was dependent on the presence of nitrite reductase (NIR) that reduces nitrite (NO(2) (-)) to nitric oxide (NO) and was repressed in PAO1 in the presence of carboxy-PTIO, a NO antagonist, demonstrating that cell elongation involves a process to respond to NO, a spontaneous byproduct of the anaerobic respiration. Nitrites 49-56 nitrite reductase Pseudomonas aeruginosa PAO1 68-71 21075189-8 2011 Both extracts inhibited LPS-stimulated iNOS gene expression and that of its transcription factor, NF-kappaB, in parallel with nitrite reduction. Nitrites 126-133 toll-like receptor 4 Mus musculus 24-27 20706193-6 2011 In Ang II + HS fed KO mice, the urinary excretion rate of nitrite/nitrate (U(NOx)V) markedly increased but 8-isoprostane excretion rate remained unchanged. Nitrites 58-65 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 3-9 21184738-8 2011 While nNOS inhibition at 4h was associated with a trend toward improved survival and significantly reduced contents of lung nitrite/nitrate (NO(x)) and liver malondialdehyde, the blockade of nNOS at 8h had no effect on these parameters. Nitrites 124-131 nitric oxide synthase 1, neuronal Mus musculus 6-10 21934298-9 2011 Apoptosis and nitrite level were abrogated when beta-thal/HbE and control cells were treated with S-methylisothiourea sulfate, an iNOS inhibitor. Nitrites 14-21 nitric oxide synthase 2 Homo sapiens 130-134 21512227-6 2011 Furthermore, the contents of hepatic nitrite, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) were elevated after CCl4 treatment, while cytochrome P450 2E1 (CYP2E1) expression was suppressed. Nitrites 37-44 C-C motif chemokine ligand 4 Rattus norvegicus 135-139 21899406-3 2011 The aim of this study was to determine the role of the T-786C and Glu298Asp polymorphisms of the eNOS gene on nitrite concentrations following Hg exposure in humans. Nitrites 110-117 nitric oxide synthase 3 Homo sapiens 97-101 22164326-10 2011 Nitrites were higher in NT than in HT (1066.1 +- 86.3 pmol/mg; n = 11 versus 487.8 +- 51.6; n = 23; P < 0.01) and inhibited by nNOS inhibitor. Nitrites 0-8 nitric oxide synthase 1 Homo sapiens 130-134 21185441-2 2011 The first step, oxidation of ammonia to nitrite, is performed by a phylogenetically restricted group of proteobacteria (ammonia-oxidizing bacteria, AOB) and Crenarchaea (ammonia-oxidizing archaea, AOA). Nitrites 40-47 aprataxin Homo sapiens 197-200 20598578-2 2011 Using the nitrite method, we investigated sequential changes in CuZn and Mn SOD activity in the cerebrospinal fluid (CSF) of 8 patients with acute ischemic stroke. Nitrites 10-17 superoxide dismutase 2 Homo sapiens 73-79 21792375-6 2011 To aid characterize this process, a quantitative analysis of nitrite generation was undertaken on agents developed to lower TNF-alpha levels in cell culture. Nitrites 61-68 tumor necrosis factor Homo sapiens 124-133 21514473-1 2011 Cytochrome c nitrite reductase, NrfA, catalyzes the six-electron reduction of nitrite, NO(2)(-), to ammonium, NH(4)(+), as the final enzymatic step in the dissimilatory metabolic pathway of nitrite ammonification within the biogeochemical nitrogen cycle. Nitrites 13-20 cytochrome c, somatic Homo sapiens 0-12 21514473-1 2011 Cytochrome c nitrite reductase, NrfA, catalyzes the six-electron reduction of nitrite, NO(2)(-), to ammonium, NH(4)(+), as the final enzymatic step in the dissimilatory metabolic pathway of nitrite ammonification within the biogeochemical nitrogen cycle. Nitrites 78-85 cytochrome c, somatic Homo sapiens 0-12 21401295-4 2011 Heme oxygenase-1 and nitric oxide synthase-2 gene expressions were significantly increased, along with levels of their products, bilirubin and nitrite. Nitrites 143-150 heme oxygenase 1 Rattus norvegicus 0-44 20696493-4 2010 Recently, the anaerobically induced Fdx5 as well as Fdx2, which is involved in nitrite reduction were characterized in more detail. Nitrites 79-86 uncharacterized protein Chlamydomonas reinhardtii 36-40 20696493-4 2010 Recently, the anaerobically induced Fdx5 as well as Fdx2, which is involved in nitrite reduction were characterized in more detail. Nitrites 79-86 uncharacterized protein Chlamydomonas reinhardtii 52-56 20958070-7 2010 To further probe the role of the metals, we studied how small molecules such as nitrite (NO(2)(-)), azide (N(3)(-)), and carbon monoxide (CO) interact with the PHM copper ions. Nitrites 80-87 peptidylglycine alpha-amidating monooxygenase Homo sapiens 160-163 20815776-6 2010 It is shown that palmitate caused induction of iNOS resulting in increased nitrite/nitrate concentration and slight increase in TG content. Nitrites 75-82 nitric oxide synthase 2 Rattus norvegicus 47-51 20702831-9 2010 In addition, both omega-3 PUFAs demonstrated reduced responsiveness to VEGF-stimulated superoxide and nitrite release and significantly impaired endothelial wound healing, proliferation, and angiogenic sprout formation. Nitrites 102-109 vascular endothelial growth factor A Homo sapiens 71-75 20738805-3 2010 Nitrate reductase enzyme activity is responsible for the reduction of nitrate to nitrite, and nitrate is the major form of nitrogen assimilated in plants. Nitrites 81-88 nitrate reductase [NADH] 1 Zea mays 0-17 20854429-7 2010 Ammonia, ANP and cANP((4-23)) added separately, each stimulated formation of NO(x) (nitrates + nitrites) which was associated with up-regulation of the activity [cANP((4-23))] or/and expression (ammonia) of the endothelial isoform of nitric oxide synthase. Nitrites 95-103 FAM111 trypsin like peptidase B Homo sapiens 17-21 21053976-9 2010 Furthermore, the compound 2 bulk-modified carbon-paste electrode (2-CPE) displays good electrocatalytic activity toward the reduction of nitrite. Nitrites 137-144 carboxypeptidase E Homo sapiens 68-71 20451602-4 2010 This combination of IFNgamma+LPS synergized to produce maximal amounts of nitrite as early as 16h. Nitrites 74-81 interferon gamma Mus musculus 20-28 20854429-7 2010 Ammonia, ANP and cANP((4-23)) added separately, each stimulated formation of NO(x) (nitrates + nitrites) which was associated with up-regulation of the activity [cANP((4-23))] or/and expression (ammonia) of the endothelial isoform of nitric oxide synthase. Nitrites 95-103 FAM111 trypsin like peptidase B Homo sapiens 162-166 20921441-9 2010 nNOS overexpression also caused a significant increase in mitochondrial nitrite levels accompanied by a decrease of cytochrome c oxidase activity. Nitrites 72-79 nitric oxide synthase 1, neuronal Mus musculus 0-4 20969801-14 2010 Probability of UTI increases to 93.3% and 90.1% at >= 10(2) CFU/ml and >= 10(3) CFU/ml respectively when presence of hematuria is combined with a positive dipstick result for nitrites. Nitrites 181-189 alpha-1-microglobulin/bikunin precursor Homo sapiens 15-18 20543077-8 2010 These results suggest that ALDH2 plays an important role in the bioactivation of GTN and nitrite in the pulmonary and systemic vascular beds and that the reduction of nitrite to vasoactive NO does not play an important role in mediating vasodilator responses to GTN in the intact chest rat. Nitrites 89-96 aldehyde dehydrogenase 2 family member Rattus norvegicus 27-32 20543082-4 2010 Concurrent stimulation of quiescent rat aortic SMCs with lipopolysaccharide (LPS) and interferon (IFN)-gamma increased COX-2, iNOS, and nitrite production. Nitrites 136-143 interferon gamma Rattus norvegicus 86-108 20498409-12 2010 In contrast, BALF nitrite+nitrate levels were decreased in apoA-I(-/-) mice. Nitrites 18-25 apolipoprotein A-I Mus musculus 59-65 20694272-8 2010 TPA was applied to monitoring photochemical OH production by nitrate, nitrite and dissolved organic matter (DOM), and OH quenching rate constants measured for DOM were similar to results from previous studies. Nitrites 70-77 plasminogen activator, tissue type Homo sapiens 0-3 20399279-8 2010 Oral nitrite supplementation to colitis mice reversed colonic nitrite levels and TNF-alpha expression to that of normal control mice at day 3, resulting in the reduction of MPO activity as well as iNOS and HO-1 expressions in colonic tissues with clinical and histological improvements at day 7. Nitrites 5-12 tumor necrosis factor Mus musculus 81-90 20675542-4 2010 In addition, myoglobin may also protect the heart against reactive oxygen species (ROS), and, under hypoxic conditions, deoxygenated myoglobin is able to reduce nitrite to NO(*) leading to a downregulation of the cardiac energy status and to a decreased heart injury after reoxygenation. Nitrites 161-168 myoglobin Homo sapiens 13-22 20675542-4 2010 In addition, myoglobin may also protect the heart against reactive oxygen species (ROS), and, under hypoxic conditions, deoxygenated myoglobin is able to reduce nitrite to NO(*) leading to a downregulation of the cardiac energy status and to a decreased heart injury after reoxygenation. Nitrites 161-168 myoglobin Homo sapiens 133-142 20551918-3 2010 Rats receiving co-treatment with dietary BH(4) and eNOS gene transfer (the [eNOS, +BH(4)] group) had greater eNOS expression, phospho-eNOS expression (Ser(1177)), Ca(2+)-dependent NOS activity, and nitrite + nitrate concentrations in the ischemic gastrocnemius than did rats receiving AdeNOS alone. Nitrites 198-205 nitric oxide synthase 3 Rattus norvegicus 51-55 20399279-8 2010 Oral nitrite supplementation to colitis mice reversed colonic nitrite levels and TNF-alpha expression to that of normal control mice at day 3, resulting in the reduction of MPO activity as well as iNOS and HO-1 expressions in colonic tissues with clinical and histological improvements at day 7. Nitrites 5-12 myeloperoxidase Mus musculus 173-176 20399279-8 2010 Oral nitrite supplementation to colitis mice reversed colonic nitrite levels and TNF-alpha expression to that of normal control mice at day 3, resulting in the reduction of MPO activity as well as iNOS and HO-1 expressions in colonic tissues with clinical and histological improvements at day 7. Nitrites 5-12 nitric oxide synthase 2, inducible Mus musculus 197-201 20399279-8 2010 Oral nitrite supplementation to colitis mice reversed colonic nitrite levels and TNF-alpha expression to that of normal control mice at day 3, resulting in the reduction of MPO activity as well as iNOS and HO-1 expressions in colonic tissues with clinical and histological improvements at day 7. Nitrites 5-12 heme oxygenase 1 Mus musculus 206-210 20568729-0 2010 Synchrotron X-ray-induced photoreduction of ferric myoglobin nitrite crystals gives the ferrous derivative with retention of the O-bonded nitrite ligand. Nitrites 61-68 myoglobin Homo sapiens 51-60 20524697-9 2010 Herein, the first spectroscopic characterization of the initial complexes of the two isoproteins NP4 and NP7 with nitrite is presented and compared to the data reported for metHb and met-myoglobin (metMb). Nitrites 114-121 proteinase 3 Homo sapiens 97-100 20524697-12 2010 Furthermore, X-ray crystallography of NP4 crystals soaked with nitrite revealed the formation of an eta(1)-N nitro complex, which is in contrast to the eta(1)-O-bound nitrite in metMb and metHb. Nitrites 63-70 proteinase 3 Homo sapiens 38-41 20568729-0 2010 Synchrotron X-ray-induced photoreduction of ferric myoglobin nitrite crystals gives the ferrous derivative with retention of the O-bonded nitrite ligand. Nitrites 138-145 myoglobin Homo sapiens 51-60 20568729-1 2010 Exposure of a single crystal of the nitrite adduct of ferric myoglobin (Mb) at 100 K to high-intensity synchrotron X-ray radiation resulted in changes in the UV-vis spectrum that can be attributed to reduction of the ferric compound to the ferrous derivative. Nitrites 36-43 myoglobin Homo sapiens 61-70 20568729-1 2010 Exposure of a single crystal of the nitrite adduct of ferric myoglobin (Mb) at 100 K to high-intensity synchrotron X-ray radiation resulted in changes in the UV-vis spectrum that can be attributed to reduction of the ferric compound to the ferrous derivative. Nitrites 36-43 myoglobin Homo sapiens 72-74 20530708-0 2010 Meat processing and colon carcinogenesis: cooked, nitrite-treated, and oxidized high-heme cured meat promotes mucin-depleted foci in rats. Nitrites 50-57 solute carrier family 13 member 2 Rattus norvegicus 110-115 20666390-0 2010 EPR spectroscopy of nitrite complexes of methemoglobin. Nitrites 20-27 hemoglobin subunit gamma 2 Homo sapiens 41-54 20666390-3 2010 In this Article, we report combined UV-vis and comprehensive electron paramagnetic resonance (EPR) spectroscopic studies that address intriguing questions raised in recent studies of the structure and affinity of the nitrite ligand in complexes with Fe(III) in methemoglobin (metHb). Nitrites 217-224 hemoglobin subunit gamma 2 Homo sapiens 261-274 20666390-3 2010 In this Article, we report combined UV-vis and comprehensive electron paramagnetic resonance (EPR) spectroscopic studies that address intriguing questions raised in recent studies of the structure and affinity of the nitrite ligand in complexes with Fe(III) in methemoglobin (metHb). Nitrites 217-224 hemoglobin subunit gamma 2 Homo sapiens 276-281 20666390-9 2010 Our results also reconfirm that the affinity of nitrite for metHb is of millimolar magnitude, thereby making a direct role for nitrite in physiological hypoxic vasodilation difficult to justify. Nitrites 48-55 hemoglobin subunit gamma 2 Homo sapiens 60-65 20666390-9 2010 Our results also reconfirm that the affinity of nitrite for metHb is of millimolar magnitude, thereby making a direct role for nitrite in physiological hypoxic vasodilation difficult to justify. Nitrites 127-134 hemoglobin subunit gamma 2 Homo sapiens 60-65 20085572-9 2010 Although CNP 100 nM and 1 microM was observed to increase nitrite + nitrate (stable metabolites of NO) production in HUVEC two-fold above basal level, the soluble guanylyl cyclase inhibitor ODQ 10 microM did not significantly modify CNP-stimulated cGMP accumulation suggesting that endothelial actions of CNP may be NO-independent. Nitrites 58-65 natriuretic peptide C Homo sapiens 9-12 20540490-3 2010 In the denitrification step, the process of nitrite removal was close to a zero-order reaction if the concentration of electron donor was not so low (COD > 100 mg L(-1)), and concentrations of nitrite and organic matter (as COD) had limited effect on denitrification rate. Nitrites 44-51 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 150-153 20540490-3 2010 In the denitrification step, the process of nitrite removal was close to a zero-order reaction if the concentration of electron donor was not so low (COD > 100 mg L(-1)), and concentrations of nitrite and organic matter (as COD) had limited effect on denitrification rate. Nitrites 44-51 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 227-230 20795898-5 2010 However, the utilization of external rhodanese significantly enhanced the in vivo efficacy of both sulfur donor-nitrite combinations, indicating the potential usefulness of enzyme nano-delivery systems in developing antidotal therapeutic agents. Nitrites 112-119 thiosulfate sulfurtransferase, mitochondrial Mus musculus 37-46 20204669-7 2010 Nitrite concentration reduced from 6.50 +/- 0.21 to 2.57 +/- 0.18 micromol/l (p < 0.001), ESR from 40.90 +/- 6.00 to 11.50 +/- 1.38 mm in the first hour (p < 0.001), and CRP level from 29.08 +/- 4.11 to 2.69 +/- 0.43 mg/dl (p < 0.001). Nitrites 0-7 C-reactive protein Homo sapiens 176-179 21063509-11 2010 Positive correlations were detected between the serum ET-1 and nitrite levels with disease activity in BD patients. Nitrites 63-70 endothelin 1 Homo sapiens 54-58 20388518-0 2010 C-peptide stimulates nitrites generation via the calcium-JAK2/STAT1 pathway in murine macrophage Raw264.7 cells. Nitrites 21-29 Janus kinase 2 Mus musculus 57-61 20388518-0 2010 C-peptide stimulates nitrites generation via the calcium-JAK2/STAT1 pathway in murine macrophage Raw264.7 cells. Nitrites 21-29 signal transducer and activator of transcription 1 Mus musculus 62-67 20388518-10 2010 This up-regulation of nitrites generation also correlated with the induction of inducible nitric oxide synthase (iNOS), a prominent marker of macrophage activation. Nitrites 22-30 nitric oxide synthase 2, inducible Mus musculus 80-111 20388518-10 2010 This up-regulation of nitrites generation also correlated with the induction of inducible nitric oxide synthase (iNOS), a prominent marker of macrophage activation. Nitrites 22-30 nitric oxide synthase 2, inducible Mus musculus 113-117 20092674-6 2010 Plasma intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 correlated positively with plasma 3-nitrotyrosine (p=0.019) and nitrite/nitrate (p=0.019), respectively. Nitrites 143-150 vascular cell adhesion molecule 1 Homo sapiens 45-78 20092674-7 2010 Furthermore, plasma interleukin-1beta also positively correlated with plasma nitrite/nitrate (p=0.003). Nitrites 77-84 interleukin 1 beta Homo sapiens 20-37 19533679-2 2010 Here, we show that training rats in an object recognition (OR) learning task rapidly increased nitrites/nitrates (NOx) content in the CA1 region of the dorsal hippocampus while posttraining intra-CA1 microinfusion of the neuronal NO synthase (nNOS) inhibitor L-NN hindered OR LTM retention without affecting memory retrieval or other behavioral variables. Nitrites 95-103 carbonic anhydrase 1 Rattus norvegicus 134-137 19931631-7 2010 Moreover, CSE induced the release of nitrite via iNOS in human PA smooth muscle cells. Nitrites 37-44 nitric oxide synthase 2 Homo sapiens 49-53 20620549-8 2010 Nitrite accumulation in the supernatants revealed that rapamycin decreased nitrite release induced by interleukin-1beta but did not affect basal or A23187-stimulated nitrite levels. Nitrites 0-7 interleukin 1 beta Rattus norvegicus 102-119 20620549-8 2010 Nitrite accumulation in the supernatants revealed that rapamycin decreased nitrite release induced by interleukin-1beta but did not affect basal or A23187-stimulated nitrite levels. Nitrites 75-82 interleukin 1 beta Rattus norvegicus 102-119 20213743-7 2010 Most interestingly, the nitrite production was significantly reduced in eNOS and Cdk5/p35 co-transfected SH-SY5Y cells when compared with co-transfection of Cdk5/p35 and S113A. Nitrites 24-31 nitric oxide synthase 3 Homo sapiens 72-76 20019368-10 2010 CONCLUSIONS: Fas-FasL interaction in the cornea balances the host innate immune response to improve disease outcome by promoting earlier apoptosis and regulating proinflammatory cytokines/chemokines and nitric oxide (nitrite) production. Nitrites 217-224 Fas ligand (TNF superfamily, member 6) Mus musculus 17-21 20213743-7 2010 Most interestingly, the nitrite production was significantly reduced in eNOS and Cdk5/p35 co-transfected SH-SY5Y cells when compared with co-transfection of Cdk5/p35 and S113A. Nitrites 24-31 cyclin dependent kinase 5 Homo sapiens 81-85 20213743-7 2010 Most interestingly, the nitrite production was significantly reduced in eNOS and Cdk5/p35 co-transfected SH-SY5Y cells when compared with co-transfection of Cdk5/p35 and S113A. Nitrites 24-31 cyclin dependent kinase 5 regulatory subunit 1 Homo sapiens 86-89 20213743-7 2010 Most interestingly, the nitrite production was significantly reduced in eNOS and Cdk5/p35 co-transfected SH-SY5Y cells when compared with co-transfection of Cdk5/p35 and S113A. Nitrites 24-31 cyclin dependent kinase 5 regulatory subunit 1 Homo sapiens 162-165 19823118-11 2010 Ketamine and TLR2 siRNA could reduce the LTA-induced increases in production of nitrite and intracellular reactive oxygen species in macrophages, and their combination had better effects than a single exposure. Nitrites 80-87 toll like receptor 2 Homo sapiens 13-17 20509045-0 2010 Nitrite, a reactive nitrogen species, protects human alpha-2-macroglobulin from halogenated oxidant, HOCl. Nitrites 0-7 alpha-2-macroglobulin Homo sapiens 53-74 20509045-4 2010 Our studies further suggest that at physiological concentrations, nitrite offered significant protection against HOCl induced alpha(2)M inactivation. Nitrites 66-73 alpha-2-macroglobulin Homo sapiens 126-135 20448437-8 2010 In contrast, endothelial nitric oxide synthase (eNOS) was expressed in both types of EPCs, and both cell types could produce nitric oxide (NO), as judged by measuring the total amounts of nitrites and nitrates in culture media. Nitrites 188-196 nitric oxide synthase 3 Homo sapiens 13-46 20097754-5 2010 In contrast, nitro derivatives of unsaturated fatty acids (NO(2)-FA) are endogenous products of nitric oxide ((*)NO) and nitrite (NO(2)(-))-mediated redox reactions that activate PPARgamma at nanomolar concentrations. Nitrites 121-128 peroxisome proliferator activated receptor gamma Mus musculus 179-188 19962433-11 2010 Capillarisin and genipin decreased nitrite release from IFN-gamma-stimulated macrophages. Nitrites 35-42 interferon gamma Mus musculus 56-65 20159982-6 2010 This protective effect of PGIS against cytokine toxicity correlated with a decreased activation of the transcription factor NFkappaB and the inducible NO synthase promoter as well as a reduced inducible NO synthase protein expression and nitrite production. Nitrites 238-245 prostaglandin I2 synthase Rattus norvegicus 26-30 19948193-4 2010 Ruthenium red (1 nmol), TRPV4 AS (40 microg, daily for 7 days) or L-NAME (300 nmol) decreased nitrite (an index of nitric oxide formation) in the DRG of CCD rats. Nitrites 94-101 transient receptor potential cation channel, subfamily V, member 4 Rattus norvegicus 24-29 20067832-3 2010 PCB treatment reduced inducible nitric oxide synthase (iNOS) expression as well as levels of nitrite/nitrate in both cell lines. Nitrites 93-100 pyruvate carboxylase Homo sapiens 0-3 20022949-9 2010 Accordingly, depletion of MTA1 by either miR-661 or siRNA in HBx-expressing cells severely impaired the ability of HBx to modulate the endogenous levels of iNOS and nitrite production. Nitrites 165-172 metastasis associated 1 Homo sapiens 26-30 20022949-9 2010 Accordingly, depletion of MTA1 by either miR-661 or siRNA in HBx-expressing cells severely impaired the ability of HBx to modulate the endogenous levels of iNOS and nitrite production. Nitrites 165-172 X protein Hepatitis B virus 61-64 20022949-9 2010 Accordingly, depletion of MTA1 by either miR-661 or siRNA in HBx-expressing cells severely impaired the ability of HBx to modulate the endogenous levels of iNOS and nitrite production. Nitrites 165-172 X protein Hepatitis B virus 115-118 19892029-0 2010 Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice. Nitrites 46-53 nitric oxide synthase 3, endothelial cell Mus musculus 9-42 19836457-7 2010 Deoxygenated myoglobin reduces nitrite to bioactive NO(*). Nitrites 31-38 myoglobin Homo sapiens 13-22 19836457-10 2010 During myocardial reperfusion after ischemia, myoglobin - via nitrite - regulates respiration and cellular viability. Nitrites 62-69 myoglobin Homo sapiens 46-55 19836457-12 2010 The reaction between myoglobin and nitrite thus seems to play an imminent role in the regulation of cardiac function in physiology and pathophysiology. Nitrites 35-42 myoglobin Homo sapiens 21-30 19892029-2 2010 In addition to other reductase pathways, endothelial NO synthase (eNOS) may also facilitate nitrite reduction in ischemic environments. Nitrites 92-99 nitric oxide synthase 3, endothelial cell Mus musculus 66-70 19892029-7 2010 Moreover, nitrite treatment enhanced renal dysfunction in the form of increased plasma [creatinine] in eNOS KO mice. Nitrites 10-17 nitric oxide synthase 3, endothelial cell Mus musculus 103-107 19892029-8 2010 Confirmation of nitrite reductase activity of eNOS was provided by demonstration of nitrite (100 microM)-derived NO production by kidney homogenates of WT mice, that was significantly reduced by L-NMMA. Nitrites 16-23 nitric oxide synthase 3, endothelial cell Mus musculus 46-50 19892029-10 2010 These results support a role for eNOS in the pathways activated during renal IRI and also identify eNOS as a nitrite reductase in ischemic conditions; activity which in part underlies the protective effects of nitrite. Nitrites 109-116 nitric oxide synthase 3, endothelial cell Mus musculus 99-103 19895897-0 2010 An electron paramagnetic resonance study of the affinity of nitrite for methemoglobin. Nitrites 60-67 hemoglobin subunit gamma 2 Homo sapiens 72-85 20142047-11 2010 In GF mice pretreated with the xanthine oxidase inhibitor allopurinol the increase in nitrite was attenuated. Nitrites 86-93 xanthine dehydrogenase Mus musculus 31-47 19895897-4 2010 Of potential importance to these reactions is the affinity of methemoglobin for nitrite and the reactivity of nitrite-bound methemoglobin with nitric oxide. Nitrites 80-87 hemoglobin subunit gamma 2 Homo sapiens 62-75 19895897-4 2010 Of potential importance to these reactions is the affinity of methemoglobin for nitrite and the reactivity of nitrite-bound methemoglobin with nitric oxide. Nitrites 110-117 hemoglobin subunit gamma 2 Homo sapiens 124-137 19895897-5 2010 In this paper, we review work related to the electronic structure of nitrite-bound methemoglobin and its dissociation constant. Nitrites 69-76 hemoglobin subunit gamma 2 Homo sapiens 83-96 19895897-6 2010 We present new data using electron paramagnetic resonance spectroscopy which confirm that methemoglobin has a much higher affinity for nitrite, under certain conditions, than reported in classical observations. Nitrites 135-142 hemoglobin subunit gamma 2 Homo sapiens 90-103 19895897-7 2010 Interestingly the affinity is greatest at lower pH and low nitrite:methemoglobin ratios. Nitrites 59-66 hemoglobin subunit gamma 2 Homo sapiens 67-80 20026772-0 2010 Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation. Nitrites 0-7 xanthine dehydrogenase Mus musculus 119-142 20192931-7 2010 Our results have shown that the patients with E. coli UTI frequently had fever higher than 38,5 degrees C (p<0,0001), chills (p=0,0349), headache (p=0,0499), cloudy urine (p<0,0001), proteinuria (p=0,0011) and positive nitrite-test (p=0,0002). Nitrites 225-232 alpha-1-microglobulin/bikunin precursor Homo sapiens 54-57 20065149-10 2010 Together, these results suggest that mPGES-1-derived PGE(2) confers protection against DOCA-salt hypertension likely via inhibition of oxidative stress or stimulation of superoxide dismutase-3 and urinary nitrate/nitrite system. Nitrites 213-220 prostaglandin E synthase Mus musculus 37-44 19460129-10 2010 Although there was no different clinical phenotype or coronary outcome in KD patients with or without UTI, we suggest that UTI should be considered and evaluated in KD patients with pyuria, a positive nitrite test or a positive result of urine culture. Nitrites 201-208 alpha-1-microglobulin/bikunin precursor Homo sapiens 123-126 20026772-6 2010 In vitro and in vivo studies revealed that nitrite in the lung was metabolized directly to nitric oxide in a process significantly enhanced under hypoxia and found to be dependent on the enzymatic action of xanthine oxidoreductase. Nitrites 43-50 xanthine dehydrogenase Mus musculus 207-230 20026772-7 2010 Additionally, physiological levels of nitrite inhibited hypoxia-induced proliferation of cultured pulmonary artery smooth muscle cells via the nitric oxide-dependent induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Nitrites 38-45 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 217-220 20026772-7 2010 Additionally, physiological levels of nitrite inhibited hypoxia-induced proliferation of cultured pulmonary artery smooth muscle cells via the nitric oxide-dependent induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Nitrites 38-45 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 221-225 20026772-7 2010 Additionally, physiological levels of nitrite inhibited hypoxia-induced proliferation of cultured pulmonary artery smooth muscle cells via the nitric oxide-dependent induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Nitrites 38-45 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 226-230 20026772-8 2010 The therapeutic effect of nitrite on hypoxia-induced pulmonary hypertension was significantly reduced in the p21-knockout mouse; however, nitrite still reduced pressures and right ventricular pathological remodeling, indicating the existence of p21-independent effects as well. Nitrites 26-33 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 109-112 20184147-1 2010 The capacity of nitrite, S-nitrosothiols (RS-NO), dinitrosyl iron complexes (DNICs) with thiol-containing ligands, and nitrosoamines to inhibit catalase has been used for the selective determination of these compounds in purely chemical systems and biological liquids: cow milk and colostram. Nitrites 16-23 catalase Bos taurus 144-152 19902188-6 2010 The present sensor was successfully used to determine nitrite in real samples of mineral water, tap water, rain water, and seawater. Nitrites 54-61 nuclear RNA export factor 1 Homo sapiens 96-99 20377513-4 2010 In mammalian blood, nitrite, present at nanomolar concentrations, can be reduced to bioactive NO along a physiological oxygen and pH gradient either non-enzymatically (acidic disproportionation) or by a number of enzymes including xanthine oxidoreductase, NOS, mitochondrial cytochromes and deoxygenated haemoglobin and myoglobin. Nitrites 20-27 xanthine dehydrogenase Homo sapiens 231-254 20331429-1 2010 Infiltration of wheat (Triticum aestivum L.) seedling leaves with excess of nitrate, nitrite, or the NO donor sodium nitroprusside leads to increase both in content of hydroperoxide and activity of peroxidase and decrease in superoxide dismutase (SOD) activity in the leaf apoplast. Nitrites 85-92 superoxide dismutase 1 Homo sapiens 225-245 20331429-1 2010 Infiltration of wheat (Triticum aestivum L.) seedling leaves with excess of nitrate, nitrite, or the NO donor sodium nitroprusside leads to increase both in content of hydroperoxide and activity of peroxidase and decrease in superoxide dismutase (SOD) activity in the leaf apoplast. Nitrites 85-92 superoxide dismutase 1 Homo sapiens 247-250 19515062-2 2010 The aim of the present study was to determine the relationship between plasma concentrations of nitrite/nitrate (NO(x)) and endothelin (ET)-1 and non-invasive measures of peripheral vasodilator function in patients with coronary artery disease (CAD). Nitrites 96-103 endothelin 1 Homo sapiens 124-141 20150881-6 2010 RESULTS: VIP and NPY in ganglion induced an increase of progesterone release that was associated for VIP, but not NPY, with a decrease of ovarian nitrite levels, iNOS protein, and NGF/trkA receptor mRNA expression. Nitrites 146-153 vasoactive intestinal peptide Rattus norvegicus 9-12 19568691-8 2010 CONCLUSION: Modulating Gng12 mRNA levels using RNAi revealed a novel role for the factor in the negative regulation of the overall inflammatory response as based on effects on nitrite and TNFalpha levels. Nitrites 176-183 guanine nucleotide binding protein (G protein), gamma 12 Mus musculus 23-28 20150881-6 2010 RESULTS: VIP and NPY in ganglion induced an increase of progesterone release that was associated for VIP, but not NPY, with a decrease of ovarian nitrite levels, iNOS protein, and NGF/trkA receptor mRNA expression. Nitrites 146-153 neuropeptide Y Rattus norvegicus 17-20 19887113-3 2010 In cultured rat primary microglia, activation of PAR-2 induced nitrite production by PKC- and MAPKs-dependent mechanism. Nitrites 63-70 F2R like trypsin receptor 1 Rattus norvegicus 49-54 19808863-13 2010 However, low molar nitrite prevented RA-induced SSEA1 downregulation and decreased betaIII-tubulin appearance. Nitrites 19-26 fucosyltransferase 4 Homo sapiens 48-53 20023878-0 2009 Kinetics and mechanism of the Co(II)-assisted oxidation of L-ascorbic acid by dioxygen and nitrite in aqueous solution. Nitrites 91-98 mitochondrially encoded cytochrome c oxidase II Homo sapiens 30-35 19934018-0 2009 Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent manner. Nitrites 0-7 tumor necrosis factor Mus musculus 65-68 19934018-2 2009 Reduction of nitrite to NO may occur enzymatically at low pH and oxygen tension by deoxyhemoglobin, deoxymyoglobin, xanthine oxidase, mitochondrial complexes, or NO synthase (NOS). Nitrites 13-20 xanthine dehydrogenase Mus musculus 116-132 19934018-2 2009 Reduction of nitrite to NO may occur enzymatically at low pH and oxygen tension by deoxyhemoglobin, deoxymyoglobin, xanthine oxidase, mitochondrial complexes, or NO synthase (NOS). Nitrites 13-20 nitric oxide synthase 1, neuronal Mus musculus 162-173 19934018-4 2009 Mechanistically, nitrite-dependent protection was not associated with inhibition of mitochondrial complex I activity, as previously demonstrated for ischemia-reperfusion, but was largely abolished in mice deficient for the soluble guanylate cyclase (sGC) alpha1 subunit, one of the principal intracellular NO receptors and signal transducers in the cardiovasculature. Nitrites 17-24 guanylate cyclase 1, soluble, alpha 1 Mus musculus 223-261 19801639-0 2009 Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite. Nitrites 106-113 aldehyde oxidase 1 Homo sapiens 51-67 19836543-2 2009 The method consists of the extraction of MPO from aqueous solutions by immobilized anti-MPO antibodies followed by a washing (to eliminate the extraction medium and the biological fluid with their possible interfering molecules) and the measurement of the activity of MPO with a detection system containing a fluorogenic substrate, H(2)O(2) and nitrite ions as reaction enhancer. Nitrites 345-352 myeloperoxidase Homo sapiens 41-44 19801639-2 2009 Although AO has structural similarity to bacterial nitrite reductases, it is unknown whether AO-catalyzed nitrite reduction can be an important source of NO. Nitrites 51-58 aldehyde oxidase 1 Homo sapiens 9-11 19801639-3 2009 The mechanism, magnitude, and quantitative importance of AO-mediated nitrite reduction in tissues have not been reported. Nitrites 69-76 aldehyde oxidase 1 Homo sapiens 57-59 19801639-6 2009 In the presence of typical aldehyde substrates or NADH, AO reduced nitrite to NO. Nitrites 67-74 aldehyde oxidase 1 Homo sapiens 56-58 19801639-7 2009 Kinetics of AO-catalyzed nitrite reduction followed Michaelis-Menten kinetics under anaerobic conditions. Nitrites 25-32 aldehyde oxidase 1 Homo sapiens 12-14 19801639-12 2009 Thus, AO-catalyzed nitrite reduction can be an important source of NO generation, and its NO production will be further increased by therapeutic administration of nitrite. Nitrites 19-26 aldehyde oxidase 1 Homo sapiens 6-8 19801639-12 2009 Thus, AO-catalyzed nitrite reduction can be an important source of NO generation, and its NO production will be further increased by therapeutic administration of nitrite. Nitrites 163-170 aldehyde oxidase 1 Homo sapiens 6-8 19801492-11 2009 The maintenance of cardioprotection in female mice lacking GPx1 post-I/R may be due to an improved ascorbate redox homeostasis and enhanced nitrate-to-nitrite conversion, which would predictably be accompanied by enhanced production of cardioprotective nitric oxide. Nitrites 151-158 glutathione peroxidase 1 Mus musculus 59-63 20029546-0 2009 Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat. Nitrites 22-29 xanthine dehydrogenase Rattus norvegicus 46-69 20029546-0 2009 Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat. Nitrites 22-29 aldehyde dehydrogenase 2 family member Rattus norvegicus 74-110 20029546-3 2009 It has been hypothesized that deoxyhemoglobin, xanthine oxidoreductase, mitochondrial aldehyde dehydrogenase, and other heme proteins can reduce nitrite to NO, but studies in the literature have not identified the mechanism in the intact rat, and several studies report no effect of inhibitors of xanthine oxidoreductase. Nitrites 145-152 xanthine dehydrogenase Rattus norvegicus 47-70 20029546-3 2009 It has been hypothesized that deoxyhemoglobin, xanthine oxidoreductase, mitochondrial aldehyde dehydrogenase, and other heme proteins can reduce nitrite to NO, but studies in the literature have not identified the mechanism in the intact rat, and several studies report no effect of inhibitors of xanthine oxidoreductase. Nitrites 145-152 aldehyde dehydrogenase 2 family member Rattus norvegicus 72-108 20029546-3 2009 It has been hypothesized that deoxyhemoglobin, xanthine oxidoreductase, mitochondrial aldehyde dehydrogenase, and other heme proteins can reduce nitrite to NO, but studies in the literature have not identified the mechanism in the intact rat, and several studies report no effect of inhibitors of xanthine oxidoreductase. Nitrites 145-152 xanthine dehydrogenase Rattus norvegicus 297-320 20029546-14 2009 The results of these studies suggest that nitrite can be reduced to vasoactive NO in the systemic vascular bed of the rat by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase and that the 2 pathways of nitrite activation act in a parallel manner. Nitrites 42-49 xanthine dehydrogenase Rattus norvegicus 125-148 20029546-14 2009 The results of these studies suggest that nitrite can be reduced to vasoactive NO in the systemic vascular bed of the rat by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase and that the 2 pathways of nitrite activation act in a parallel manner. Nitrites 42-49 aldehyde dehydrogenase 2 family member Rattus norvegicus 153-189 20097961-2 2009 We tested glycerol trinitrate (GTN) and other well-known NO donors together with those bearing a >C=N-OH group for possible conversion to NO (or nitrites, respectively) by diaphorase (DP) and lipoamide dehydrogenase (LAD). Nitrites 148-156 dihydrolipoamide dehydrogenase Homo sapiens 187-189 18544592-9 2009 A significant decrease in mean total nitric oxide (NOx), nitrite, and nitrate levels was also found after G-CSF plus dexamethasone administration. Nitrites 57-64 colony stimulating factor 3 Homo sapiens 106-111 19811527-10 2009 Nitrates/nitrites and TBARS, metabolites of MMPs activators, were increased in the diabetic placenta and reduced by 15dPGJ(2). Nitrites 9-17 matrix metallopeptidase 2 Rattus norvegicus 44-48 19795347-6 2009 In contrast, the glutathione reductase concentrations did not decrease during the first phase of reperfusion and were directly correlated with those of antioxidants, endothelin levels increased less than in the untreated groups and, in the case of nitroglycerin, the nitrite concentration was significantly greater than in the remaining groups. Nitrites 267-274 glutathione-disulfide reductase Homo sapiens 17-38 20516270-7 2009 We also show that the reduction in plasma MMP-9 levels was associated with a change in plasma nitrites/nitrates (NOx) concentration over the entire intervention (r = -0.38, p < 0.05; week 12 vs. baseline). Nitrites 94-102 matrix metallopeptidase 9 Homo sapiens 42-47 19524003-9 2009 Significant increases in expression of endothelial (eNOS) and inducible (iNOS) isoforms of NOS mRNA and protein occurred only at coma stages of encephalopathy accompanied by increased brain nitrite/nitrate concentrations. Nitrites 190-197 nitric oxide synthase 2 Rattus norvegicus 73-77 19573522-12 2009 Co-treatment with propofol and TLR2 siRNA synergistically ameliorated LTA-induced iNOS mRNA expression and nitrite production. Nitrites 107-114 toll like receptor 2 Homo sapiens 31-35 19467284-9 2009 Treatment with Sema4D/CD100 inhibited the production of nitrites and LPS-induced microglia migration. Nitrites 56-64 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Mus musculus 15-21 19467284-9 2009 Treatment with Sema4D/CD100 inhibited the production of nitrites and LPS-induced microglia migration. Nitrites 56-64 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Mus musculus 22-27 19785658-12 2009 AFP also increased H(2)O(2) and modulated nitrite/nitrate levels in non-stimulated keratinocytes whereas it did not affect these parameters or cytokine release from UVA-stimulated cells. Nitrites 42-49 alpha fetoprotein Homo sapiens 0-3 19756487-9 2009 Cytokine-exposed Irf-1 (-/-) islets and INS-1E cells transfected with Irf-1 siRNA showed increased expression of Mcp-1 (also known as Ccl2), Ip-10 (also known as Cxcl10), Mip-3alpha (also known as Ccl20) and Inos (also known as Nos2) mRNA and elevated production of monocyte chemoattractant protein-1 (MCP-1) and nitrite compared with controls. Nitrites 313-320 interferon regulatory factor 1 Rattus norvegicus 17-22 19756487-9 2009 Cytokine-exposed Irf-1 (-/-) islets and INS-1E cells transfected with Irf-1 siRNA showed increased expression of Mcp-1 (also known as Ccl2), Ip-10 (also known as Cxcl10), Mip-3alpha (also known as Ccl20) and Inos (also known as Nos2) mRNA and elevated production of monocyte chemoattractant protein-1 (MCP-1) and nitrite compared with controls. Nitrites 313-320 interferon regulatory factor 1 Rattus norvegicus 70-75 19737619-2 2009 The aim of the present clinical study was to investigate the relationship between the NO metabolites nitrite and nitrate and the biomarkers of oxidative stress 3-nitrotyrosine (3-NT) and 15(S)-iso-PGF(2alpha) in patients suffering from chronic inflammatory rheumatic diseases. Nitrites 101-108 placental growth factor Homo sapiens 197-200 20081243-5 2009 Moreover, nitrite levels in brain slices incubated in the presence of alpha-synuclein were measured using the Griess reaction. Nitrites 10-17 synuclein alpha Rattus norvegicus 70-85 20081243-8 2009 Under the same experimental conditions, alpha-synuclein increased nitrite levels by 27%. Nitrites 66-73 synuclein alpha Rattus norvegicus 40-55 19665947-10 2009 GSH externally added to lysed RBC inhibited nitrite-induced methemoglobin formation. Nitrites 44-51 hemoglobin subunit gamma 2 Homo sapiens 60-73 19432590-12 2009 A significant positive correlation between tissue nitrite and eNOS protein contents was also observed. Nitrites 50-57 nitric oxide synthase 3 Sus scrofa 62-66 19574557-5 2009 In addition, Nox2 deficiency was associated with increased antioxidant and nitrite concentrations in plasma, together with a preserved expression of eNOS in ischemic tissues. Nitrites 75-82 cytochrome b-245, beta polypeptide Mus musculus 13-17 19586913-1 2009 The reduction of nitrite (NO2-) into nitric oxide (NO), catalyzed by nitrite reductase, is an important reaction in the denitrification pathway. Nitrites 17-24 nitrite reductase large subunit Achromobacter xylosoxidans 69-86 19733718-6 2009 The concentrations of plasma endothelin-1, a potent vasoconstrictor peptide produced by vascular endothelial cells, significantly decreased and plasma nitric oxide (measured as the stable end product [nitrite/nitrate]), a potent vasodilator produced by vascular endothelial cells, significantly increased after the weight-reduction exercise program. Nitrites 201-208 endothelin 1 Homo sapiens 29-41 19672189-7 2009 Isoflurane at 2%, but not at 1 or 3%, reduced the lipopolysaccharide and IFNgamma-induced nitrite production and decreased cell viability. Nitrites 90-97 interferon gamma Mus musculus 73-81 19809847-5 2009 Our results showed, when compared with control aliquots, that the presence of fibrinogen modulates the NO mobilization in erythrocytes by (1) decreasing erythrocyte NO efflux levels (P < 0.001); (2) increasing levels of intraerythrocytic NO oxidative metabolites, namely, nitrite (P < 0.0001) and nitrate (P < 0.0001); and (3) enhancing the formation of GSNO (P < 0.001). Nitrites 275-282 fibrinogen beta chain Homo sapiens 78-88 19597697-4 2009 Furthermore, phylogenetic analyses of microbial phylotypes present at our highest sites (5410 m above sea level) showed the presence of nitrifying bacteria of the genus Nitrospira and newly discovered nitrite-oxidizing Betaproteobacteria. Nitrites 201-208 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 102-105 19501543-4 2009 The method was applied to the determination of nitrite in tap water and lake water with satisfactory results. Nitrites 47-54 nuclear RNA export factor 1 Homo sapiens 58-61 19576290-4 2009 Nitrite inhibited the respiration of isolated A. thaliana mitochondria, in competition with oxygen, an effect that was abolished or potentiated when electron flow occurred via alternative oxidase (AOX) or cytochrome c oxidase (COX), respectively. Nitrites 0-7 alternative oxidase 2 Arabidopsis thaliana 176-195 19576290-4 2009 Nitrite inhibited the respiration of isolated A. thaliana mitochondria, in competition with oxygen, an effect that was abolished or potentiated when electron flow occurred via alternative oxidase (AOX) or cytochrome c oxidase (COX), respectively. Nitrites 0-7 alternative oxidase 2 Arabidopsis thaliana 197-200 19576290-8 2009 These results show that the accumulation of nitric oxide derived from nitrite reduction and the superoxide-dependent mechanism of NO degradation in isolated A. thaliana mitochondria are influenced by the external NAD(P)H dehydrogenases and AOX, revealing a role for these alternative proteins of the mitochondrial respiratory chain in the control of NO levels in plant cells. Nitrites 70-77 alternative oxidase 2 Arabidopsis thaliana 240-243 19594749-7 2009 With regard to the nitric oxide-dependent component, we confirm that aldehyde oxidase, but not xanthine oxidase or endothelial nitric oxide synthase, was important for the actions of nitrite in our model. Nitrites 183-190 aldehyde oxidase 1 Homo sapiens 69-85 27877301-4 2009 The Cu-CPE showed excellent electrocatalytic activities toward the reduction of hydrogen peroxide and nitrite, and the detection limit was much lower than that mentioned in earlier reports. Nitrites 102-109 carboxypeptidase E Homo sapiens 7-10 19635671-5 2009 Red blood cell CA activity was inhibited in the treated animals at 3-5h post-administration (in the range of 60-85%), probably due to NO/nitrite formed by PDE5 inhibition or by another, unknown mechanism. Nitrites 137-144 phosphodiesterase 5A Homo sapiens 155-159 19531636-5 2009 Topical application of SHH restored wound healing delay in STZ-induced diabetic mice, with a concomitant augmentation of both cutaneous constitutive nitric oxide synthase (NOS) activity and nitrite level. Nitrites 190-197 sonic hedgehog Mus musculus 23-26 19727605-3 2009 Thus, the conversion of nitrite into NO during cellular stress may be an evolutionarily conserved and redundant means for NO generation at a time when endothelial nitric oxide synthase is non-functional. Nitrites 24-31 nitric oxide synthase 3 Homo sapiens 151-184 19594749-12 2009 Having investigated possible nitrite reduction sites, we confirm that aldehyde oxidase is important for the actions of nitrite. Nitrites 29-36 aldehyde oxidase 1 Homo sapiens 70-86 19594749-12 2009 Having investigated possible nitrite reduction sites, we confirm that aldehyde oxidase is important for the actions of nitrite. Nitrites 119-126 aldehyde oxidase 1 Homo sapiens 70-86 19628069-8 2009 In correlation with graft survival, mRNA levels for interferon-gamma in the spleen or tumor necrosis factor-alpha in the grafts were significantly less when animals were fed nitrite water compared with those without nitrite supplementation. Nitrites 174-181 interferon gamma Rattus norvegicus 52-68 19481167-7 2009 We hypothesized that nitrite would provide an ischemic NO source that could be potentiated by TSP1-CD47 blockade enhancing ischemic tissue survival, blood flow and angiogenesis. Nitrites 21-28 thrombospondin 1 Homo sapiens 94-98 19481167-7 2009 We hypothesized that nitrite would provide an ischemic NO source that could be potentiated by TSP1-CD47 blockade enhancing ischemic tissue survival, blood flow and angiogenesis. Nitrites 21-28 CD47 molecule Homo sapiens 99-103 19628069-8 2009 In correlation with graft survival, mRNA levels for interferon-gamma in the spleen or tumor necrosis factor-alpha in the grafts were significantly less when animals were fed nitrite water compared with those without nitrite supplementation. Nitrites 174-181 tumor necrosis factor Rattus norvegicus 86-113 19345570-0 2009 A nitrite biosensor based on the immobilization of cytochrome c on multi-walled carbon nanotubes-PAMAM-chitosan nanocomposite modified glass carbon electrode. Nitrites 2-9 cytochrome c, somatic Homo sapiens 51-63 19506075-2 2009 ALDH2 denitrates GTN to 1,2-glyceryl dinitrate and nitrite but also catalyzes reduction of GTN to NO. Nitrites 51-58 aldehyde dehydrogenase 2 family member Homo sapiens 0-5 19398497-5 2009 EX-4 inhibited IL-1beta-induced iNOS protein expression and nitrite production. Nitrites 60-67 interleukin 1 beta Rattus norvegicus 15-23 19398497-14 2009 We therefore concluded that EX-4 inhibited IL-1beta-induced iNOS protein and nitrite production via cAMP/PKA system irrespective of both transcriptional and posttranscriptional mechanisms of iNOS gene, and this inhibitory effect of EX-4 appears to be regulated at posttranslational level. Nitrites 77-84 interleukin 1 beta Rattus norvegicus 43-51 20592767-11 2009 These results suggest that there is a direct relationship between the lipid peroxidation and nitrite contents during epileptic activity that can be responsible for the superoxide dismutase and catalase enzymatic activity changes observed during the establishment of seizures and SE induced by pilocarpine. Nitrites 93-100 catalase Rattus norvegicus 193-201 19150571-0 2009 Nitrite or sildenafil, but not BAY 41-2272, blunt acute pulmonary embolism-induced increases in circulating matrix metalloproteinase-9 and oxidative stress. Nitrites 0-7 matrix metallopeptidase 9 Canis lupus familiaris 108-134 19150571-11 2009 While nitrite and sildenafil blunted the increases in plasma pro-MMP-9 levels and TBARS (all P<0.05), BAY 41-2272 produced no such effects. Nitrites 6-13 matrix metallopeptidase 9 Canis lupus familiaris 65-70 19150571-12 2009 Nitrite and sildenafil produced in vitro antioxidant effects and inhibited MMPs only at high concentrations. Nitrites 0-7 matrix metallopeptidase 9 Canis lupus familiaris 75-79 19345570-1 2009 A novel nitrite biosensor was successfully prepared via immobilizing Cytochrome c (Cyt c) onto the multi-walled carbon nanotubes-poly(amidoamine) (PAMAM)-chitosan (MWNT-PAMAM-Chit) nanocomposite modified glass carbon electrode (GCE). Nitrites 8-15 cytochrome c, somatic Homo sapiens 69-81 19345570-1 2009 A novel nitrite biosensor was successfully prepared via immobilizing Cytochrome c (Cyt c) onto the multi-walled carbon nanotubes-poly(amidoamine) (PAMAM)-chitosan (MWNT-PAMAM-Chit) nanocomposite modified glass carbon electrode (GCE). Nitrites 8-15 cytochrome c, somatic Homo sapiens 83-88 19345570-1 2009 A novel nitrite biosensor was successfully prepared via immobilizing Cytochrome c (Cyt c) onto the multi-walled carbon nanotubes-poly(amidoamine) (PAMAM)-chitosan (MWNT-PAMAM-Chit) nanocomposite modified glass carbon electrode (GCE). Nitrites 8-15 chitinase 1 Homo sapiens 175-179 19448598-0 2009 Nitrite-methemoglobin inadequate for hypoxic vasodilation. Nitrites 0-7 hemoglobin subunit gamma 2 Homo sapiens 8-21 19488452-4 2009 Moreover, the electrochemical properties of the title complex bulk-modified carbon paste electrode (La-CPE) have been studied, and the results indicate that the La-CPE has good electrocatalytic activities towards the reduction of hydrogen peroxide, nitrite, bromate and trichloroacetic acid (TCA). Nitrites 249-256 carboxypeptidase E Homo sapiens 103-106 19488452-4 2009 Moreover, the electrochemical properties of the title complex bulk-modified carbon paste electrode (La-CPE) have been studied, and the results indicate that the La-CPE has good electrocatalytic activities towards the reduction of hydrogen peroxide, nitrite, bromate and trichloroacetic acid (TCA). Nitrites 249-256 carboxypeptidase E Homo sapiens 164-167 19811271-3 2009 Here, we assessed the biological activity of the serum CD154 tetramer using bioassays for BC activation and production nitrite or peroxide. Nitrites 119-126 CD40 ligand Homo sapiens 55-60 19371593-6 2009 The highest levels of both iNOS gene expression and its activity (increased wound fluid citrulline and nitrites) were at the first day. Nitrites 103-111 nitric oxide synthase 2 Rattus norvegicus 27-31 19269449-2 2009 The most common way to quantify nitrite, for instance in nitric oxide synthase (NOS) mechanistic investigations, is the spectrophotometric assay based on the Griess reaction through external standard calibration. Nitrites 32-39 nitric oxide synthase 2 Homo sapiens 57-78 19673940-13 2009 In contrast with Ad-PGK-infected cells, in cardiomyocytes infected with Ad-eNOS, there was increased calcium-dependent NOS activity and nitrite production. Nitrites 136-143 phosphoglycerate kinase 1 Rattus norvegicus 20-23 19286940-7 2009 A role for anion exchanger (AE)-1 in the control of nitrite export was suggested by increased intracellular nitrite concentrations in RBCs treated with DIDS. Nitrites 52-59 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 11-33 19286940-7 2009 A role for anion exchanger (AE)-1 in the control of nitrite export was suggested by increased intracellular nitrite concentrations in RBCs treated with DIDS. Nitrites 108-115 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 11-33 19286940-8 2009 Moreover, deoxygenation decreased steady-state levels of intracellular nitrite in AE-1-inhibited RBCs. Nitrites 71-78 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 82-86 19286940-9 2009 Based on these data, we propose a model in which deoxyhemoglobin binding to AE-1 inhibits nitrite export under low oxygen tensions allowing for the coupling between deoxygenation and nitrite reduction to NO along the arterial-to-venous gradient. Nitrites 90-97 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 76-80 19286940-9 2009 Based on these data, we propose a model in which deoxyhemoglobin binding to AE-1 inhibits nitrite export under low oxygen tensions allowing for the coupling between deoxygenation and nitrite reduction to NO along the arterial-to-venous gradient. Nitrites 183-190 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 76-80 19673940-13 2009 In contrast with Ad-PGK-infected cells, in cardiomyocytes infected with Ad-eNOS, there was increased calcium-dependent NOS activity and nitrite production. Nitrites 136-143 nitric oxide synthase 3 Rattus norvegicus 75-79 19384567-9 2009 Finally, in vitro administration of ghrelin prevented 1-methyl-4-phenylpyridinium-induced dopaminergic cell loss, MMP-3 expression, microglial activation, and the subsequent release of TNF-alpha, IL-1beta, and nitrite in mesencephalic cultures. Nitrites 210-217 ghrelin Mus musculus 36-43 19326597-15 2009 Transpulmonary loss of plasma nitrite indicates either less pulmonary nitric oxide (NO) production, which contributes to higher PASP, or increased NO bioavailability arising from nitrite reduction, which may oppose ET-1-mediated vasoconstriction. Nitrites 30-37 endothelin 1 Homo sapiens 215-219 19325986-10 2009 STM shows that the morphology of the particle system is largely conserved during NO(2) exposure at 300 K. The reaction is limited to the formation of surface nitrites and nitrates, which are characterized by low thermal stability and completely decompose below 500 K. As no further sintering occurs before decomposition, NO(2) uptake and release is a fully reversible process. Nitrites 158-166 sulfotransferase family 1A member 3 Homo sapiens 0-3 22683445-5 2012 I hypothesize that NO may suppress BPG production by (1) inhibiting glyceraldehyde-3-phosphate dehydrogenase (G3PDH), the most critical glycolytic enzyme for the bioavailability of 1,3-bisphosphoglycerate; and to a lesser extent by (2) associated pH changes in the deoxy-Hb-catalyzed depletion of nitrite, a metabolic reservoir of NO. Nitrites 297-304 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 68-108 22683445-5 2012 I hypothesize that NO may suppress BPG production by (1) inhibiting glyceraldehyde-3-phosphate dehydrogenase (G3PDH), the most critical glycolytic enzyme for the bioavailability of 1,3-bisphosphoglycerate; and to a lesser extent by (2) associated pH changes in the deoxy-Hb-catalyzed depletion of nitrite, a metabolic reservoir of NO. Nitrites 297-304 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 110-115 19243126-5 2009 To address this question, we systematically studied hSod1 peroxidase activity in the presence of nitrite, formate, and bicarbonate-carbon dioxide. Nitrites 97-104 superoxide dismutase 1 Homo sapiens 52-57 19243126-6 2009 Kinetic analyses of hydrogen peroxide consumption and of nitrite, formate, and bicarbonate-carbon dioxide oxidation showed that the Sod1-bound hydroxyl-like oxidant functions in the presence of nitrite and formate. Nitrites 57-64 superoxide dismutase 1 Homo sapiens 132-136 19243126-6 2009 Kinetic analyses of hydrogen peroxide consumption and of nitrite, formate, and bicarbonate-carbon dioxide oxidation showed that the Sod1-bound hydroxyl-like oxidant functions in the presence of nitrite and formate. Nitrites 194-201 superoxide dismutase 1 Homo sapiens 132-136 19174156-7 2009 Treatment with SnPP, a selective inhibitor of HO-1, reversed the KB-34-mediated inhibition of nitrite production, suggesting that HO-1 plays an important role in the suppression of NO production by KB-34. Nitrites 94-101 heme oxygenase 1 Homo sapiens 46-50 19046140-2 2009 In the present work, we tested the in vitro ability of the three NOS (nitric oxide synthase) isoforms to release NO from nitrite under anoxia using electrochemical detection, chemiluminescence and absorption spectroscopy. Nitrites 121-128 nitric oxide synthase 1 Homo sapiens 70-91 19046140-5 2009 Our data suggest that structural and, by inference, dynamic differences between nNOS and eNOS in the distal haem side account for eNOS being the only isoform capable of converting nitrite into NO at pH 7.6. Nitrites 180-187 nitric oxide synthase 1 Homo sapiens 80-84 19034402-6 2009 Interestingly, the competitive GSH-mediated inhibition of MMP-1-activity can be fully reversed abrogated by oxidizing radicals like (*)NO(2) or Trolox radicals, here generated by UVA irradiation of nitrite or Trolox, two relevant agents in human skin physiology. Nitrites 198-205 matrix metallopeptidase 1 Homo sapiens 58-63 19041694-9 2009 Similarly, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide reduction increased 3.5-fold (P<0.05), and Abeta-induced nitrite production was reduced by 65% when exposed to moderate acidosis compared with basal pH media (P<0.05). Nitrites 132-139 amyloid beta precursor protein Rattus norvegicus 118-123 18996902-6 2009 Compared with wild-type, bronchoalveolar lavage fluid (BALF) levels of nitrite plus nitrate, GM-CSF, and MCP-1, but not TNF-alpha and IFN-gamma, were higher in SP-D-deficient mice before and after HSCT. Nitrites 71-78 surfactant associated protein D Mus musculus 160-164 19074675-5 2009 Under elevated tone conditions, decreases in pulmonary and systemic arterial pressures in response to nitrite were attenuated by allopurinol in a dose that did not alter responses to the NO donors, sodium nitroprusside and diethylamine/NO, suggesting that xanthine oxidoreductase is the major enzyme-reducing nitrite to NO. Nitrites 102-109 xanthine dehydrogenase Rattus norvegicus 256-279 19074675-9 2009 These data provide evidence that xanthine oxidoreductase is the major enzyme-reducing nitrite to vasoactive NO, and that this mechanism is not modified by hypoxia. Nitrites 86-93 xanthine dehydrogenase Rattus norvegicus 33-56 18975252-7 2009 However, FasL mediated comparable effects on the mitochondrial transmembrane potential (Deltapsi (m)) and nitrite in cytokine- and untreated cells. Nitrites 106-113 Fas ligand (TNF superfamily, member 6) Mus musculus 9-13 19064940-8 2009 Pretreatment of cells with the PAR-1 inhibitor, SCH-79797, resulted in a significant decrease in thrombin- and TFLLR-induced phosphorylation of eNOS-Thr495 and an increase in nitrite production. Nitrites 175-182 coagulation factor II thrombin receptor Homo sapiens 31-36 18618322-5 2009 Inhibition data of the cytosolic isozymes hCA I - hCA III with a large number of anions (halides, pseudohalides, bicarbonate, carbonate, nitrate, nitrite, hydrosulfide, sulfate, sulfamic acid, sulfamide, etc. Nitrites 146-153 carbonic anhydrase 1 Homo sapiens 42-47 18618322-5 2009 Inhibition data of the cytosolic isozymes hCA I - hCA III with a large number of anions (halides, pseudohalides, bicarbonate, carbonate, nitrate, nitrite, hydrosulfide, sulfate, sulfamic acid, sulfamide, etc. Nitrites 146-153 HCA1 Homo sapiens 42-45 19174156-7 2009 Treatment with SnPP, a selective inhibitor of HO-1, reversed the KB-34-mediated inhibition of nitrite production, suggesting that HO-1 plays an important role in the suppression of NO production by KB-34. Nitrites 94-101 heme oxygenase 1 Homo sapiens 130-134 19121076-6 2009 Bone marrow-derived macrophages from the knockout mice killed C. albicans yeasts efficiently in vitro, and were still able to produce nitrites in an iNOS-independent manner, albeit less efficiently than wild-type controls. Nitrites 134-142 nitric oxide synthase 2, inducible Mus musculus 149-153 18951990-1 2009 Reduction of nitrite to nitric oxide (NO) by components of the mitochondrial respiratory chain may link nitroglycerin biotransformation by mitochondrial aldehyde dehydrogenase (ALDH2) to activation of soluble guanylate cyclase (sGC). Nitrites 13-20 aldehyde dehydrogenase 2 family member Homo sapiens 177-182 19147590-0 2009 Comment re: Nitrite activates estrogen receptor-alpha. Nitrites 12-19 estrogen receptor 1 Homo sapiens 30-53 19183880-7 2009 Treatment with SnPP, a selective HO-1 inhibitor, reversed YL-I-108-mediated suppression of nitrite production, suggesting that HO-1 induction is implicated in the suppression of NO production by YL-I-108. Nitrites 91-98 heme oxygenase 1 Mus musculus 127-131 20027156-13 2009 Nitrite levels correlated positively with C-reactive protein, total white blood cells, and triglycerides. Nitrites 0-7 C-reactive protein Homo sapiens 42-60 18801604-4 2009 CL-20 degradation was accompanied by the formation of formate, glyoxal, nitrite, ammonium, and nitrous oxide. Nitrites 72-79 epithelial membrane protein 1 Homo sapiens 0-5 19001185-13 2009 However, in mice lacking iNOS, maximum and minimum dP/dt, as well as an indicator of isovolumic contraction, markedly increased in response to isoproterenol, associated with decreased cardiac 4-hydroxy-2-nonenal expression and urinary nitrate/nitrite. Nitrites 243-250 nitric oxide synthase 2, inducible Mus musculus 25-29 19759441-1 2009 During ultraviolet light (UV) disinfection, nitrate (NO3-) present in raw water may transform to nitrite (NO2-) that can cause serious human diseases. Nitrites 97-104 NBL1, DAN family BMP antagonist Homo sapiens 53-56 19053540-4 2008 In particular, the quantum yield (phi) of nitrite formation was measured and found to significantly decrease at high concentrations of nitrate for Ca(NO(3))(2). Nitrites 42-49 glucose-6-phosphate isomerase Homo sapiens 34-37 18993072-2 2008 The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as scCA, has been cloned, purified, characterized kinetically, and investigated for its inhibition with a series simple, inorganic anions such as halogenides, pseudohalogenides, bicarbonate, carbonate, nitrate, nitrite, hydrogen sulfide, bisulfite, perchlorate, sulfate, and some of its isosteric species. Nitrites 333-340 carbonate dehydratase NCE103 Saccharomyces cerevisiae S288C 27-33 18818404-11 2008 iNOS expression correlated with increased nitrite contents. Nitrites 42-49 LOC396821 Sus scrofa 0-4 19075471-5 2008 Calibration graphs with linearity in the range of 0.7 - 40 muM were obtained for both nitrite and nitrate. Nitrites 86-93 latexin Homo sapiens 59-62 18820338-4 2008 In this report, we show for the first time that the mitochondrial electron carrier cytochrome c can also effectively reduce nitrite to NO. Nitrites 124-131 cytochrome c, somatic Homo sapiens 83-95 18820338-6 2008 Further, we demonstrate that in the presence of nitrite, pentacoordinate cytochrome c generates bioavailable NO that is able to inhibit mitochondrial respiration. Nitrites 48-55 cytochrome c, somatic Homo sapiens 73-85 19005069-8 2008 By injecting LPS in the striatum of WT and Nox1-KO mice, we show that Nox1 also enhances microglial production of cytotoxic nitrite species and promotes loss of presynaptic proteins in striatal neurons. Nitrites 124-131 NADPH oxidase 1 Mus musculus 70-74 18824664-6 2008 The cGMP agonists 8-bromo-cGMP and C-type natriuretic peptide also stimulated DDAH-2 gene and protein expression levels and DDAH activity and increased the amount of nitrite/nitrate released into the culture supernatants. Nitrites 166-173 natriuretic peptide C Rattus norvegicus 35-61 18820031-9 2008 Approximately 40% of this pH-sensitive increase in nitrite consumption could be blocked by the xanthine oxidoreductase inhibitor allopurinol, whereas lowering the Po(2) sufficiently to desaturate myoglobin accelerated it further. Nitrites 51-58 xanthine dehydrogenase Rattus norvegicus 95-118 18820031-10 2008 We conclude that rat heart contains several factors capable of catalyzing ischemic nitrite reduction; the most potent is contained within erythrocytes and activated by hypoxia, whereas the remainder includes xanthine oxidoreductase and other pH-sensitive factors endogenous to heart tissue, including deoxymyoglobin. Nitrites 83-90 xanthine dehydrogenase Rattus norvegicus 208-231 18837492-5 2008 Four energetically accessible reaction routes are revealed, i.e., the decomposition of the nitrite adduct forming C 2Cl 3O + NO and its sequential dissociation to CO + NO + CCl 3, the elimination of ClNO from the nitrite adduct leading to ClNO + Cl 2CCO, the Cl-atom shift of the nitrite adduct followed by the decomposition to CCl 3CO + NO, and the O-atom shift of the nitro adduct followed by C-C bond cleavage forming ClCNO + Cl 2CO. Nitrites 91-98 C-C motif chemokine ligand 3 Homo sapiens 173-178 18837492-5 2008 Four energetically accessible reaction routes are revealed, i.e., the decomposition of the nitrite adduct forming C 2Cl 3O + NO and its sequential dissociation to CO + NO + CCl 3, the elimination of ClNO from the nitrite adduct leading to ClNO + Cl 2CCO, the Cl-atom shift of the nitrite adduct followed by the decomposition to CCl 3CO + NO, and the O-atom shift of the nitro adduct followed by C-C bond cleavage forming ClCNO + Cl 2CO. Nitrites 213-220 C-C motif chemokine ligand 3 Homo sapiens 173-178 18837492-5 2008 Four energetically accessible reaction routes are revealed, i.e., the decomposition of the nitrite adduct forming C 2Cl 3O + NO and its sequential dissociation to CO + NO + CCl 3, the elimination of ClNO from the nitrite adduct leading to ClNO + Cl 2CCO, the Cl-atom shift of the nitrite adduct followed by the decomposition to CCl 3CO + NO, and the O-atom shift of the nitro adduct followed by C-C bond cleavage forming ClCNO + Cl 2CO. Nitrites 213-220 C-C motif chemokine ligand 3 Homo sapiens 173-178 18818408-6 2008 Thus, XOR and eNOS are ideally situated on the membranes of RBCs and blood vessels to generate intravascular vasodilator NO from nitrite during ischemic episodes. Nitrites 129-136 xanthine dehydrogenase Homo sapiens 6-9 18818408-6 2008 Thus, XOR and eNOS are ideally situated on the membranes of RBCs and blood vessels to generate intravascular vasodilator NO from nitrite during ischemic episodes. Nitrites 129-136 nitric oxide synthase 3 Homo sapiens 14-18 18818408-3 2008 Herein, we have demonstrated that conversion of nitrite to NO by blood vessels and RBCs was enhanced in the presence of the XOR substrate xanthine (10 micromol/L) and attenuated by the XOR inhibitor allopurinol (100 micromol/L) in acidic and hypoxic conditions only. Nitrites 48-55 xanthine dehydrogenase Homo sapiens 124-127 18701635-8 2008 Further analysis revealed that reduction of CBS activity during reperfusion was accompanied by an elevation of NO metabolites (nitrate and nitrite) in the kidney tissue. Nitrites 139-146 cystathionine beta synthase Rattus norvegicus 44-47 18818408-3 2008 Herein, we have demonstrated that conversion of nitrite to NO by blood vessels and RBCs was enhanced in the presence of the XOR substrate xanthine (10 micromol/L) and attenuated by the XOR inhibitor allopurinol (100 micromol/L) in acidic and hypoxic conditions only. Nitrites 48-55 xanthine dehydrogenase Homo sapiens 185-188 18851742-8 2008 RESULTS: The prophylactic HCE treatment increased the mice survival, the neutrophil migration to infectious site, the spreading ability and the hydrogen peroxide release, but decreased the serum TNF and nitrite. Nitrites 203-210 RNA guanylyltransferase and 5'-phosphatase Mus musculus 26-29 18821940-10 2008 Moreover, IL-15 induced a more intense immunological response in CD patients after triggering the production of both nitrites and IFN gamma (P = 0.0313, P = 0.0313, respectively). Nitrites 117-125 interleukin 15 Homo sapiens 10-15 18394025-9 2008 RESULTS: Despite similar infarct size, deficiency in iNOS resulted in significantly lower plasma nitrate/nitrite levels, better haemodynamic performance and lower mortality 2 weeks after coronary ligation. Nitrites 105-112 nitric oxide synthase 2, inducible Mus musculus 53-57 18836554-15 2008 NPY -treated rat enteric neurons in vitro exhibited increased nitrite and TNF-alpha production. Nitrites 62-69 neuropeptide Y Rattus norvegicus 0-3 18682903-0 2008 Nitrite-mediated inactivation of human plasma paraoxonase-1: possible beneficial effect of aromatic amino acids. Nitrites 0-7 paraoxonase 1 Homo sapiens 46-59 18768880-8 2008 PIR-B(-/-) BMMphi also produced more nitrite and TNF-alpha upon exposure to Salmonella than WT BMMphi did. Nitrites 37-44 paired Ig-like receptor B Mus musculus 0-5 18682903-3 2008 Nitrites (NO2-), either present as a contaminant and/or the main metabolic end product of nitric oxide (NO) degradation, may trigger nitrative damage to PON-1 enzyme. Nitrites 0-8 paraoxonase 1 Homo sapiens 153-158 18682903-5 2008 The aim of this study was to analyze whether nitrites could play a role in modifying human PON-1 activity. Nitrites 45-53 paraoxonase 1 Homo sapiens 91-96 18682903-6 2008 Our results revealed that PON-1 activity was inhibited by nitrite in dose- and time-dependent manner. Nitrites 58-65 paraoxonase 1 Homo sapiens 26-31 18682903-10 2008 The inhibition of PON-1 activity by nitrite was significantly reduced by tryptophan, reduced glutathione (GSH), and catalase additions. Nitrites 36-43 paraoxonase 1 Homo sapiens 18-23 18682903-11 2008 Therefore, we concluded that nitrites may have a role in the inactivation of PON-1, probably through nitration of enzyme phenyl residues, and additions of individual aromatic amino acids, with highlighting on tryptophan, could be of important value in minimizing the nitrite-induced inhibition of PON-1 enzyme. Nitrites 29-37 paraoxonase 1 Homo sapiens 77-82 18682903-11 2008 Therefore, we concluded that nitrites may have a role in the inactivation of PON-1, probably through nitration of enzyme phenyl residues, and additions of individual aromatic amino acids, with highlighting on tryptophan, could be of important value in minimizing the nitrite-induced inhibition of PON-1 enzyme. Nitrites 29-36 paraoxonase 1 Homo sapiens 77-82 18846773-7 2008 Our results show that there exists a relationship between serum nitrites concentration and the expression of eNOS and iNOS, as analyzed in protein extracts of placental tissues. Nitrites 64-72 nitric oxide synthase 2 Homo sapiens 118-122 18765195-13 2008 Nitrite and protein levels in BAL correlated well with PVR and may therefore be used as a non-invasive marker to predict graft function for NHBDs. Nitrites 0-7 PVR cell adhesion molecule Homo sapiens 55-58 18599123-6 2008 Both neuroglobin and cytoglobin are S-nitrosated when reacting with nitrite, with neuroglobin showing higher levels of S-nitrosation. Nitrites 68-75 neuroglobin Homo sapiens 5-16 18599123-0 2008 Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditions. Nitrites 53-60 neuroglobin Homo sapiens 21-32 18599123-0 2008 Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditions. Nitrites 53-60 cytoglobin Homo sapiens 37-47 18599123-6 2008 Both neuroglobin and cytoglobin are S-nitrosated when reacting with nitrite, with neuroglobin showing higher levels of S-nitrosation. Nitrites 68-75 cytoglobin Homo sapiens 21-31 18599123-2 2008 We have investigated whether ferrous neuroglobin and cytoglobin, the two hexacoordinate globins from vertebrates expressed in brain and in a variety of tissues, respectively, also react with nitrite under anaerobic conditions. Nitrites 191-198 neuroglobin Homo sapiens 37-48 18599123-2 2008 We have investigated whether ferrous neuroglobin and cytoglobin, the two hexacoordinate globins from vertebrates expressed in brain and in a variety of tissues, respectively, also react with nitrite under anaerobic conditions. Nitrites 191-198 cytoglobin Homo sapiens 53-63 18599123-7 2008 The possible biological significance of the reaction between nitrite and neuroglobin in vivo under brain hypoxia is discussed. Nitrites 61-68 neuroglobin Homo sapiens 73-84 18599123-4 2008 Deconvolution of absorbance spectra shows that, in the course of the reaction of neuroglobin with nitrite, ferric Fe(III) heme is generated in excess of nitrosyl Fe(II)-NO heme as due to the low affinity of ferrous neuroglobin for nitric oxide. Nitrites 98-105 neuroglobin Homo sapiens 81-92 18501719-6 2008 Mice deficient in endothelial nitric oxide synthase (eNOS-/-) demonstrated decreased blood and tissue nitrite, nitrate, and nitroso proteins, which were further reduced by low-nitrite (NOx) diet for 1 week. Nitrites 102-109 nitric oxide synthase 3, endothelial cell Mus musculus 18-51 18599123-4 2008 Deconvolution of absorbance spectra shows that, in the course of the reaction of neuroglobin with nitrite, ferric Fe(III) heme is generated in excess of nitrosyl Fe(II)-NO heme as due to the low affinity of ferrous neuroglobin for nitric oxide. Nitrites 98-105 neuroglobin Homo sapiens 215-226 18501719-0 2008 Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice. Nitrites 8-15 nitric oxide synthase 3, endothelial cell Mus musculus 67-100 18501719-5 2008 We sought to determine how exogenous nitrite affects steady-state concentrations of NO metabolites thought to originate from nitric oxide synthase (NOS)-derived NO as well as blood pressure and myocardial ischemia-reperfusion (I/R) injury. Nitrites 37-44 nitric oxide synthase 1, neuronal Mus musculus 125-146 18558493-7 2008 Conversely, murine rIFN-gamma-activated mouse MPhi produced high levels of nitrite and killed intracellular M. leprae in vitro. Nitrites 75-82 interferon gamma Rattus norvegicus 19-29 18685092-5 2008 Cardiac-specific eNOS overexpression resulted in significant increases in nitrite, nitrate, and nitrosothiols in the heart, plasma, and liver. Nitrites 74-81 nitric oxide synthase 3, endothelial cell Mus musculus 17-21 18539756-9 2008 Organ chamber experiments demonstrated that aortic relaxation induced by nitrite could be blocked by both hemoglobin and soluble guanylyl cyclase (sGC) inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one (ODQ). Nitrites 73-80 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 121-145 18539756-9 2008 Organ chamber experiments demonstrated that aortic relaxation induced by nitrite could be blocked by both hemoglobin and soluble guanylyl cyclase (sGC) inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one (ODQ). Nitrites 73-80 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 147-150 18539756-11 2008 These findings thus suggest that nitrite can be a precursor of EDRF and that sGC or other heme proteins inhibited by ODQ catalyze the reduction of nitrite to NO. Nitrites 147-154 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 77-80 18455513-7 2008 RESULTS: We found significant negative correlations between pro-MMP-9 levels and plasma nitrite (P=0.035, rs= -0.159), nitrate (P=0.040, rs= -0.158), and cGMP (P=0.011, rs= -0.189) concentrations. Nitrites 88-95 matrix metallopeptidase 9 Homo sapiens 64-69 18632562-5 2008 We find that myoglobin is responsible for nitrite-dependent NO* generation and cardiomyocyte protein iron-nitrosylation. Nitrites 42-49 myoglobin Mus musculus 13-22 18756103-0 2008 Nuruk extract inhibits lipopolysaccharide-induced production of nitrite and interleukin-6 in RAW 264.7 cells through blocking activation of p38 mitogen-activated protein kinase. Nitrites 64-71 mitogen-activated protein kinase 14 Mus musculus 140-143 18756103-3 2008 Both the n-hexane and water fractions from NE (MEH and MW, respectively) inhibited the production of nitrite and IL-6 in RAW 264.7 cells. Nitrites 101-108 epoxide hydrolase 1, microsomal Mus musculus 47-50 18632562-6 2008 Nitrite reduction to NO* by myoglobin dynamically inhibits cellular respiration and limits reactive oxygen species generation and mitochondrial enzyme oxidative inactivation after I/R injury. Nitrites 0-7 myoglobin Mus musculus 28-37 18632562-7 2008 In isolated myoglobin(+/+) but not in myoglobin(-/-) hearts, nitrite treatment resulted in an improved recovery of postischemic left ventricular developed pressure of 29%. Nitrites 61-68 myoglobin Mus musculus 12-21 18632562-8 2008 In vivo administration of nitrite reduced myocardial infarction by 61% in myoglobin(+/+) mice, whereas in myoglobin(-/-) mice nitrite had no protective effects. Nitrites 26-33 myoglobin Mus musculus 74-83 18545934-5 2008 RESULTS: All inhibitors reduced the IL-1beta induced nitrite and PGE2 release in a dose-dependent manner. Nitrites 53-60 interleukin 1 beta Bos taurus 36-44 18516050-3 2008 Here we report on nitrate reductase activity in rodent and human tissues that results in formation of nitrite and nitric oxide (NO) and is attenuated by the xanthine oxidoreductase inhibitor allopurinol. Nitrites 102-109 xanthine dehydrogenase Homo sapiens 157-180 18424432-7 2008 Administration of the xanthine oxidase (XO) inhibitor oxypurinol or aldehyde oxidase (AO) inhibitor raloxifene significantly decreased NO generation from nitrite in heart or liver. Nitrites 154-161 aldehyde oxidase 1 Homo sapiens 68-84 18424432-7 2008 Administration of the xanthine oxidase (XO) inhibitor oxypurinol or aldehyde oxidase (AO) inhibitor raloxifene significantly decreased NO generation from nitrite in heart or liver. Nitrites 154-161 aldehyde oxidase 1 Homo sapiens 86-88 18424432-10 2008 Overall, NO generation from nitrite mainly occurs in tissues not in the blood, with XO and AO playing critical roles in nitrite reduction, and this process is regulated by pH, oxygen tension, nitrite, and reducing substrate concentrations. Nitrites 120-127 aldehyde oxidase 1 Homo sapiens 91-93 18450747-1 2008 Metabolism of nitroglycerin (GTN) to 1,2-glycerol dinitrate (GDN) and nitrite by mitochondrial aldehyde dehydrogenase (ALDH2) is essentially involved in GTN bioactivation resulting in cyclic GMP-mediated vascular relaxation. Nitrites 70-77 aldehyde dehydrogenase 2 family member Homo sapiens 119-124 18424432-10 2008 Overall, NO generation from nitrite mainly occurs in tissues not in the blood, with XO and AO playing critical roles in nitrite reduction, and this process is regulated by pH, oxygen tension, nitrite, and reducing substrate concentrations. Nitrites 120-127 aldehyde oxidase 1 Homo sapiens 91-93 18450747-1 2008 Metabolism of nitroglycerin (GTN) to 1,2-glycerol dinitrate (GDN) and nitrite by mitochondrial aldehyde dehydrogenase (ALDH2) is essentially involved in GTN bioactivation resulting in cyclic GMP-mediated vascular relaxation. Nitrites 70-77 5'-nucleotidase, cytosolic II Homo sapiens 191-194 18394698-0 2008 A sandwich structured SiO(2)/cytochrome c/SiO(2) on a boron-doped diamond film electrode as an electrochemical nitrite biosensor. Nitrites 111-118 cytochrome c, somatic Homo sapiens 29-41 18605556-5 2008 When either of the reduced RDX products (MNX or TNX) was treated with ZVINs we observed nitrite (from MNX only), NO (from TNX only), N2O, NH4+, NH2NH2 and HCHO. Nitrites 88-95 keratin 86 Homo sapiens 41-44 18605556-5 2008 When either of the reduced RDX products (MNX or TNX) was treated with ZVINs we observed nitrite (from MNX only), NO (from TNX only), N2O, NH4+, NH2NH2 and HCHO. Nitrites 88-95 tenascin XA (pseudogene) Homo sapiens 48-51 18465875-0 2008 Kinetics of reaction of nitrite with deoxy hemoglobin after rapid deoxygenation or predeoxygenation by dithionite measured in solution and bound to the cytoplasmic domain of band 3 (SLC4A1). Nitrites 24-31 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 182-188 18367148-10 2008 RESULTS: APC treatment significantly reduced activities of oxidative enzymes and nitrate/nitrite levels in the lung tissues, and plasma levels of proinflammatory cytokines and D-dimer, and also significantly increased activities of antioxidative enzymes (P < .05). Nitrites 89-96 APC regulator of WNT signaling pathway Rattus norvegicus 9-12 18285514-6 2008 In particular, COMP-Ang-1 gene-transferred SHRs had significantly higher plasma levels of nitrite than other controls, which was found to be due to that expressed COMP-Ang-1 protein promoted nitrite synthesis by activating endothelial nitric oxide synthase, one of the Tie2 downstream-signalling molecules. Nitrites 90-97 TEK receptor tyrosine kinase Rattus norvegicus 269-273 18285514-6 2008 In particular, COMP-Ang-1 gene-transferred SHRs had significantly higher plasma levels of nitrite than other controls, which was found to be due to that expressed COMP-Ang-1 protein promoted nitrite synthesis by activating endothelial nitric oxide synthase, one of the Tie2 downstream-signalling molecules. Nitrites 191-198 TEK receptor tyrosine kinase Rattus norvegicus 269-273 18384429-0 2008 IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells. Nitrites 27-34 interleukin 13 Homo sapiens 0-5 18459802-0 2008 Completely different effects of desferrioxamine on hemin/nitrite/H2O2-induced bovine serum albumin nitration and oxidation. Nitrites 57-64 albumin Homo sapiens 85-98 18459802-4 2008 In the hemin/nitrite/H2O2 system-induced bovine serum albumin (BSA) nitration and oxidation model, BSA was analyzed for 3-nitrotyosine and carbonyl groups measured by spectrophotometry, SDS-PAGE, and Western blotting upon exposure to DFO. Nitrites 13-20 albumin Homo sapiens 48-61 18384429-0 2008 IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells. Nitrites 27-34 nitric oxide synthase 2 Homo sapiens 79-110 18483281-5 2008 The ability of diphenyleneiodonium to block the effects of nitrate, but not nitrite, on the induction of PgR mRNA and the activation of exogenously expressed ERalpha suggests that nitrite is the active anion. Nitrites 180-187 estrogen receptor 1 Homo sapiens 158-165 18313411-6 2008 HO-1 induction with an adenoviral vector carrying HO-1 showed a decrease in total iNOS protein, nitrite production, and iNOS dimer level from cells stimulated by IL-1beta. Nitrites 96-103 interleukin 1 beta Mus musculus 162-170 18510740-13 2008 The nitrite/nitrate (NOx-) levels were markedly increased in animals submitted to acute pancreatitis as compared to SAL group, approximately 76 and 68% in TAU and PLA2 protocol, respectively. Nitrites 4-11 phospholipase A2 group IB Rattus norvegicus 163-167 18483281-2 2008 Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780. Nitrites 69-76 progesterone receptor Homo sapiens 190-211 18483281-2 2008 Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780. Nitrites 69-76 progesterone receptor Homo sapiens 213-216 18483281-6 2008 Concentrations of nitrite, as low as 100 nmol/L, induced a significant increase in PgR mRNA, suggesting that physiologically and environmentally relevant doses of the anion activate ERalpha. Nitrites 18-25 progesterone receptor Homo sapiens 83-86 18483281-2 2008 Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780. Nitrites 69-76 trefoil factor 1 Homo sapiens 219-222 18483281-2 2008 Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780. Nitrites 69-76 cathepsin D Homo sapiens 228-239 18483281-6 2008 Concentrations of nitrite, as low as 100 nmol/L, induced a significant increase in PgR mRNA, suggesting that physiologically and environmentally relevant doses of the anion activate ERalpha. Nitrites 18-25 estrogen receptor 1 Homo sapiens 182-189 18483281-7 2008 Nitrite activated the chimeric receptor Gal-ER containing the DNA-binding domain of GAL-4 and the ligand-binding domain of ERalpha and blocked the binding of estradiol to the receptor, suggesting that the anion activates ERalpha through the ligand-binding domain. Nitrites 0-7 galectin 4 Homo sapiens 84-89 18483281-7 2008 Nitrite activated the chimeric receptor Gal-ER containing the DNA-binding domain of GAL-4 and the ligand-binding domain of ERalpha and blocked the binding of estradiol to the receptor, suggesting that the anion activates ERalpha through the ligand-binding domain. Nitrites 0-7 estrogen receptor 1 Homo sapiens 123-130 18483281-7 2008 Nitrite activated the chimeric receptor Gal-ER containing the DNA-binding domain of GAL-4 and the ligand-binding domain of ERalpha and blocked the binding of estradiol to the receptor, suggesting that the anion activates ERalpha through the ligand-binding domain. Nitrites 0-7 estrogen receptor 1 Homo sapiens 221-228 18213641-9 2008 Exposure to arsenic compounds, chlorophenols, diesel fuel, herbicides, nitrites/nitrates/nitrosamines, and organic dusts were associated with NHL(high) and NHL(low), while exhibiting little association with CLL. Nitrites 71-79 regulator of telomere elongation helicase 1 Homo sapiens 142-145 18280259-0 2008 Nitration of respiratory epithelial cells by myeloperoxidase depends on extracellular nitrite. Nitrites 86-93 myeloperoxidase Homo sapiens 45-60 18203719-3 2008 However, the reaction of nitrite with oxyhemoglobin (oxyHb) is well established and generates nitrate and methemoglobin (metHb). Nitrites 25-32 hemoglobin subunit gamma 2 Homo sapiens 106-119 18203719-3 2008 However, the reaction of nitrite with oxyhemoglobin (oxyHb) is well established and generates nitrate and methemoglobin (metHb). Nitrites 25-32 hemoglobin subunit gamma 2 Homo sapiens 121-126 18213641-9 2008 Exposure to arsenic compounds, chlorophenols, diesel fuel, herbicides, nitrites/nitrates/nitrosamines, and organic dusts were associated with NHL(high) and NHL(low), while exhibiting little association with CLL. Nitrites 71-79 regulator of telomere elongation helicase 1 Homo sapiens 156-164 23105749-4 2008 A positive correlation among serum prolactin and nitrite suggested that hyperprolactinemia could contribute to infertility by inducing oxidative damage. Nitrites 49-56 prolactin Homo sapiens 35-44 18325336-0 2008 Chloroplast nitrite uptake is enhanced in Arabidopsis PII mutants. Nitrites 12-19 nitrogen regulatory P-II-like protein Arabidopsis thaliana 54-57 18325336-2 2008 We have previously observed that Arabidopsis PII mutants are more sensitive to nitrite toxicity. Nitrites 79-86 nitrogen regulatory P-II-like protein Arabidopsis thaliana 45-48 18325336-3 2008 Using intact chloroplasts isolated from Arabidopsis leaves and (15)N-labelled nitrite we show that a light-dependent nitrite uptake into chloroplasts is increased in PII knock-out mutants when compared to the wild-type. Nitrites 78-85 nitrogen regulatory P-II-like protein Arabidopsis thaliana 166-169 18325336-3 2008 Using intact chloroplasts isolated from Arabidopsis leaves and (15)N-labelled nitrite we show that a light-dependent nitrite uptake into chloroplasts is increased in PII knock-out mutants when compared to the wild-type. Nitrites 117-124 nitrogen regulatory P-II-like protein Arabidopsis thaliana 166-169 18325336-6 2008 Our observations suggest that PII is involved in the regulation of nitrite uptake into higher plant chloroplasts. Nitrites 67-74 nitrogen regulatory P-II-like protein Arabidopsis thaliana 30-33 18284212-5 2008 Of the anions studied, particularly intriguing in terms of observed trends in substrate kinetics and their novel atomic compositions were the nitrite, nitrate, and azide anions, the latter of which was found to enhance the relative activity of human pancreatic alpha-amylase by nearly 5-fold. Nitrites 142-149 amylase alpha 2A Homo sapiens 250-274 17923423-5 2008 RESULTS: TNF-alpha and IL-1beta treatment caused a 3-5 fold increase in sGAG release with an increase in aggrecanase-specific aggrecan breakdown and an increase in nitrate and nitrite production. Nitrites 176-183 tumor necrosis factor Bos taurus 9-18 17923423-5 2008 RESULTS: TNF-alpha and IL-1beta treatment caused a 3-5 fold increase in sGAG release with an increase in aggrecanase-specific aggrecan breakdown and an increase in nitrate and nitrite production. Nitrites 176-183 interleukin 1 beta Bos taurus 23-31 18158157-0 2008 Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells. Nitrites 41-48 indoleamine 2,3-dioxygenase 1 Mus musculus 63-90 18284212-10 2008 In contrast, while nitrite considerably boosts the relative activity of human pancreatic alpha-amylase, its presence leads to changes in the electrostatic environment and active site conformations that substantially modify catalytic parameters and produce a novel acarbose rearrangement product. Nitrites 19-26 amylase alpha 2A Homo sapiens 78-102 18284212-11 2008 In particular, nitrite-substituted human pancreatic alpha-amylase demonstrates the unique ability to cleave acarbose into its acarviosine and maltose parts and carry out a previously unseen product elongation. Nitrites 15-22 amylase alpha 2A Homo sapiens 41-65 18059323-11 2008 The effects of cigarette smoke extract on nitrite formation stimulated by LPS were unaffected by inhibition of nicotinic receptors with alpha-bungarotoxin (100 units ml(-1)). Nitrites 42-49 toll-like receptor 4 Mus musculus 74-77 18258363-4 2008 Levels of dsRNA-induced nitrite production in a line of immortalized murine microglia (BV2) and in primary cultures of murine microglia were decreased by inhibition of JNK or p38 MAPK, but were increased by inhibition of extracellular signal-regulated kinase. Nitrites 24-31 mitogen-activated protein kinase 8 Mus musculus 168-171 18258363-4 2008 Levels of dsRNA-induced nitrite production in a line of immortalized murine microglia (BV2) and in primary cultures of murine microglia were decreased by inhibition of JNK or p38 MAPK, but were increased by inhibition of extracellular signal-regulated kinase. Nitrites 24-31 mitogen-activated protein kinase 14 Mus musculus 175-183 18714730-7 2008 Pre-block of ACE by captopril intensified diuresis and inhibited renal excretion of OAS, nitrites and nitrates in response to T4 injection. Nitrites 89-97 angiotensin I converting enzyme Rattus norvegicus 13-16 18250410-0 2008 Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells. Nitrites 141-148 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Mus musculus 22-31 18164136-6 2008 Furthermore, at 4 weeks, the nNOS protein content and NO production as reflected by the concentration of nitrite and nitrate were drastically elevated as measured by Western blot analysis and NO colorimetric assay, respectively. Nitrites 105-112 nitric oxide synthase, brain Cavia porcellus 29-33 18059323-12 2008 However, the effects of cigarette smoke extract on LPS-induced nitrite formation were mimicked by hydrogen peroxide and reversed by the anti-oxidants N-acetyl cysteine and glutathione. Nitrites 63-70 toll-like receptor 4 Mus musculus 51-54 18199125-4 2008 We encountered that nrc mutants of denitrifying strains show a decrease in anaerobic growth rates not only with nitrate, but also with nitrite, NO and N(2)O, which is concomitant to their lower NADH oxidation activities in vitro. Nitrites 135-142 nuclear receptor coactivator 6 Homo sapiens 20-23 18199125-5 2008 We show that nitrate, nitrite and NO are activating signals for transcription of nrc in these strains. Nitrites 22-29 nuclear receptor coactivator 6 Homo sapiens 81-84 18054434-8 2008 Furthermore, exposure to exogenous NO donors inhibited SULT2B1a mRNA expression, and exposure to sodium nitroprusside, LPS/TNF-alpha and L-glutamic acid in combination with cyclothiazide increased the production of nitrite, a stable degradation product of NO. Nitrites 215-222 tumor necrosis factor Rattus norvegicus 123-132 17905436-0 2008 Crystal structures of manganese- and cobalt-substituted myoglobin in complex with NO and nitrite reveal unusual ligand conformations. Nitrites 89-96 myoglobin Homo sapiens 56-65 17905436-2 2008 Hemoglobin (Hb) and myoglobin (Mb) convert, under certain conditions, nitrite to NO. Nitrites 70-77 myoglobin Homo sapiens 20-29 17914444-2 2008 The presence of inducible NO synthase protein in a number of inflammatory dermatoses, coupled with the induction of an intense cutaneous inflammatory infiltrate following topical application of the NO donor-acidified nitrite (NO2(-)), has set the paradigm of NO being an inflammatory mediator in human skin. Nitrites 217-224 nitric oxide synthase 2 Homo sapiens 16-37 17914444-5 2008 In contrast acidified nitrite, releasing equal quantities of NO (measured by dermal microdialysis and cutaneous erythema), induces an intense epidermal infiltrate of macrophages with a similar dermal infiltrate of CD3-, CD4-, CD8-, and CD68-positive cells and neutrophils. Nitrites 22-29 CD4 molecule Homo sapiens 220-223 17914444-5 2008 In contrast acidified nitrite, releasing equal quantities of NO (measured by dermal microdialysis and cutaneous erythema), induces an intense epidermal infiltrate of macrophages with a similar dermal infiltrate of CD3-, CD4-, CD8-, and CD68-positive cells and neutrophils. Nitrites 22-29 CD8a molecule Homo sapiens 226-229 17914444-5 2008 In contrast acidified nitrite, releasing equal quantities of NO (measured by dermal microdialysis and cutaneous erythema), induces an intense epidermal infiltrate of macrophages with a similar dermal infiltrate of CD3-, CD4-, CD8-, and CD68-positive cells and neutrophils. Nitrites 22-29 CD68 molecule Homo sapiens 236-240 18161731-7 2008 Nitration of human hemoglobin by H(2)O(2)/nitrite was detected on Tyr24 and Tyr42 (alpha-chain) and on Tyr130 and Trp15 (beta-chain) in the alphabeta-dimer. Nitrites 42-49 Fc gamma receptor and transporter Homo sapiens 83-94 17983423-8 2008 Chondroitin sulfate reduced IL-1beta-induced NF-kappaB nuclear translocation, but not AP-1 translocation, it decreased IL-1beta-induced phosphorylation of Erk1/2 and abrogated p38MAPK phosphorylation, but did not prevent IL-1beta-induced increase in nitrite. Nitrites 250-257 interleukin-1 beta Oryctolagus cuniculus 28-36 18348730-11 2008 IL-1beta induced a transient increase in iNOS expression and stimulated the production of nitrite release. Nitrites 90-97 interleukin 1 beta Homo sapiens 0-8 18348730-12 2008 Stimulation by either dynamic compression or SB203580 in isolation reduced the IL-1beta induced iNOS expression and nitrite production. Nitrites 116-123 interleukin 1 beta Homo sapiens 79-87 18190523-8 2008 ANG II application enhanced the LPS-induced increases in IL-1 and nitrite concentrations, as well as the LPS-induced morphological changes and AP-1 activation, and these enhancements were inhibited by losartan (10(-5) M). Nitrites 66-73 angiotensinogen Rattus norvegicus 0-6 18006476-5 2008 METHODS AND RESULTS: Treatment of vascular EC with a FXR ligand resulted in upregulation of expression of eNOS mRNA and protein and an increased production of nitrite/nitrate. Nitrites 159-166 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 53-56 18078452-5 2008 Treatment with LPS/IFN-gamma for 24 hr elicited the induction of inducible (iNOS) activity as determined by nitrite and nitrate (NO(x)) accumulation in the culture medium. Nitrites 108-115 interferon gamma Rattus norvegicus 19-28 18326983-6 2008 Increased exogenous or endogenous CO2 deoxygenates hemoglobin, thereby increasing the fraction of hemoglobin reacting with nitrite to form methemoglobin together with release of superoxide and nitric oxide. Nitrites 123-130 hemoglobin subunit gamma 2 Homo sapiens 139-152 18078452-5 2008 Treatment with LPS/IFN-gamma for 24 hr elicited the induction of inducible (iNOS) activity as determined by nitrite and nitrate (NO(x)) accumulation in the culture medium. Nitrites 108-115 nitric oxide synthase 2 Rattus norvegicus 76-80 22062097-5 2008 Nitrite added to a batter of meat is partially oxidized to nitrate by sequestering oxygen - thus it acts as an antioxidant - a part of nitrite is bound to myoglobin, forming the heat stable NO-myoglobin, a part is bound to proteins or other substances in meat. Nitrites 0-7 myoglobin Homo sapiens 155-164 18554536-4 2008 Nitration of cytochrome c by biological oxidants in vitro can be achieved via different mechanisms, which include reactions with peroxynitrite, nitrite plus hydrogen peroxide, and nitric oxide plus hydrogen peroxide, and result in a loss in its electron transport capacity and in a higher peroxidatic activity. Nitrites 135-142 cytochrome c, somatic Homo sapiens 13-25 22062097-5 2008 Nitrite added to a batter of meat is partially oxidized to nitrate by sequestering oxygen - thus it acts as an antioxidant - a part of nitrite is bound to myoglobin, forming the heat stable NO-myoglobin, a part is bound to proteins or other substances in meat. Nitrites 0-7 myoglobin Homo sapiens 193-202 22062097-5 2008 Nitrite added to a batter of meat is partially oxidized to nitrate by sequestering oxygen - thus it acts as an antioxidant - a part of nitrite is bound to myoglobin, forming the heat stable NO-myoglobin, a part is bound to proteins or other substances in meat. Nitrites 135-142 myoglobin Homo sapiens 155-164 22062097-5 2008 Nitrite added to a batter of meat is partially oxidized to nitrate by sequestering oxygen - thus it acts as an antioxidant - a part of nitrite is bound to myoglobin, forming the heat stable NO-myoglobin, a part is bound to proteins or other substances in meat. Nitrites 135-142 myoglobin Homo sapiens 193-202 17705669-10 2008 Exogenous ghrelin administration increased gastric acid output, mucus content and total plasma nitrite levels, while these effects of ghrelin were inhibited by applying L-NAME. Nitrites 95-102 ghrelin and obestatin prepropeptide Rattus norvegicus 10-17 19062523-5 2008 NO-synthase (NOS) activity was estimated as nitrite (NO2-) accumulation in culture medium; NO2- concentration in the presence of L-NAME, inhibitor of all NOS types, was considered as NOS-independent and was subtracted from each value. Nitrites 44-51 nitric oxide synthase 3 Canis lupus familiaris 0-11 19062523-6 2008 The nitrite accumulation was linear in time during 3 days of cultivation and was inhibited by 1400W, inducible NOS (iNOS) inhibitor, and 7-nitroindazole, constitutive NOS"s inhibitor, at doses 5-50 and 10-200 microM, respectively. Nitrites 4-11 nitric oxide synthase 2 Canis lupus familiaris 116-120 19062523-6 2008 The nitrite accumulation was linear in time during 3 days of cultivation and was inhibited by 1400W, inducible NOS (iNOS) inhibitor, and 7-nitroindazole, constitutive NOS"s inhibitor, at doses 5-50 and 10-200 microM, respectively. Nitrites 4-11 nitric oxide synthase 2 Canis lupus familiaris 101-114 18044879-1 2007 In nitrite-treated cytochrome cd1 nitrite reductase, heme d1 is electron paramagnetic resonance silent but paramagnetic. Nitrites 3-10 CD1c molecule Homo sapiens 30-33 18071229-3 2007 The as-prepared gold nanoparticles attached glassy carbon electrode (Au/GCE) presented excellent catalytic ability toward the oxidation of nitrite. Nitrites 139-146 aminomethyltransferase Homo sapiens 72-75 18071229-4 2007 Compared with bare GCE and planar gold electrode, the Au/GCE obviously decreased the overpotential of nitrite oxidation and improved the peak current. Nitrites 102-109 aminomethyltransferase Homo sapiens 19-22 18071229-4 2007 Compared with bare GCE and planar gold electrode, the Au/GCE obviously decreased the overpotential of nitrite oxidation and improved the peak current. Nitrites 102-109 aminomethyltransferase Homo sapiens 57-60 18071229-5 2007 The catalytic current was found to be linearly proportional to the nitrite concentration in the range of 1 x 10(-5) - 5 x 10(-3) M, with a detection limit of 2.4 x 10(-6) M. The Au/GCE was successfully applied to the electrochemical determination of nitrite in a real wastewater sample, showing excellent stability and anti-interference ability. Nitrites 67-74 aminomethyltransferase Homo sapiens 181-184 18071229-5 2007 The catalytic current was found to be linearly proportional to the nitrite concentration in the range of 1 x 10(-5) - 5 x 10(-3) M, with a detection limit of 2.4 x 10(-6) M. The Au/GCE was successfully applied to the electrochemical determination of nitrite in a real wastewater sample, showing excellent stability and anti-interference ability. Nitrites 250-257 aminomethyltransferase Homo sapiens 181-184 17982448-1 2007 Nitrite reacts with deoxyhemoglobin to form nitric oxide (NO) and methemoglobin. Nitrites 0-7 hemoglobin subunit gamma 2 Homo sapiens 66-79 17891158-6 2007 KEY RESULTS: PPARalpha agonists GW7647 and WY14643 reduced LPS-induced NO production in a dose-dependent manner as measured by the accumulation of nitrite into the culture medium. Nitrites 147-154 peroxisome proliferator activated receptor alpha Mus musculus 13-22 17898699-4 2007 Repeated intravenous doses of cationized catalase significantly decreased cisplatin-induced changes in serum creatinine, blood urea nitrogen, nitrite/nitrate levels, lactic dehydrogenase activity, and renal total glutathione and malondialdehyde contents. Nitrites 142-149 catalase Mus musculus 41-49 17982448-3 2007 We have discovered that products of the nitrite-hemoglobin reaction generate dinitrogen trioxide (N2O3) via a novel reaction of NO and nitrite-bound methemoglobin. Nitrites 40-47 hemoglobin subunit gamma 2 Homo sapiens 149-162 17982448-3 2007 We have discovered that products of the nitrite-hemoglobin reaction generate dinitrogen trioxide (N2O3) via a novel reaction of NO and nitrite-bound methemoglobin. Nitrites 135-142 hemoglobin subunit gamma 2 Homo sapiens 149-162 17982448-4 2007 The oxygen-bound form of nitrite-methemoglobin shows a degree of ferrous nitrogen dioxide (Fe(II)-NO2*) character, so it may rapidly react with NO to form N2O3. Nitrites 25-32 hemoglobin subunit gamma 2 Homo sapiens 33-46 17982448-7 2007 Because the reaction redox-cycles (that is, regenerates ferrous heme) and the nitrite-methemoglobin intermediate is not observable by electron paramagnetic resonance spectroscopy, this reaction has been "invisible" to experimentalists over the last 100 years. Nitrites 78-85 hemoglobin subunit gamma 2 Homo sapiens 86-99 17889368-0 2007 Hemoglobin S-nitrosation on oxygenation of nitrite/deoxyhemoglobin incubations is attenuated by methemoglobin. Nitrites 43-50 hemoglobin subunit gamma 2 Homo sapiens 96-109 17998492-6 2007 RESULTS: Three of the original decision aid variables (dysuria, the presence of leukocytes [greater than a trace amount], and the presence of nitrites [any positive]) were associated with having a positive urine culture result (P < or = .001), but 1 variable (symptoms for 1 day) was not (P = .96). Nitrites 142-150 activation induced cytidine deaminase Homo sapiens 40-43 17693071-4 2007 The aim of this investigation was to characterize exhaled breath condensate nitrite in volunteers, healthy smokers, and stable COPD (GOLD-stages 0-4) and to compare this parameter with inflammatory markers in exhaled breath condensate and with lung function in order to test the hypothesis that elevated exhaled breath condensate nitrite reflects hyperinflation in COPD. Nitrites 76-83 COPD Homo sapiens 127-131 17644579-10 2007 Nitrite production was stimulated by bradykinin and carbachol in microvessels in vitro; pregnancy enhanced nitrite release. Nitrites 0-7 kininogen 1 Canis lupus familiaris 37-47 17935739-5 2007 For this purpose, the amount of stable nitrite, the end product of NO generation by activated chondrocytes, has been evaluated by Griess colorimetric reaction in culture medium of human primary chondrocytes and in the murine ATDC5 cell line stimulated with leptin (400 nM) and interferon-gamma (1 ng/ml), alone or in combination. Nitrites 39-46 leptin Mus musculus 257-263 17935739-5 2007 For this purpose, the amount of stable nitrite, the end product of NO generation by activated chondrocytes, has been evaluated by Griess colorimetric reaction in culture medium of human primary chondrocytes and in the murine ATDC5 cell line stimulated with leptin (400 nM) and interferon-gamma (1 ng/ml), alone or in combination. Nitrites 39-46 interferon gamma Mus musculus 277-293 17935739-9 2007 Pre-treatment with Wortmannin, LY 294002, PD 098,059 and SB 203580 caused a significant decrease in nitrite production, NOS type II protein expression and NOS type II mRNA expression induced by leptin and interferon-gamma co-stimulation. Nitrites 100-107 leptin Mus musculus 194-200 17600531-0 2007 Reactivity and endogenous modification by nitrite and hydrogen peroxide: does human neuroglobin act only as a scavenger? Nitrites 42-49 neuroglobin Homo sapiens 84-95 17673149-5 2007 VIP inhibited LPS-induced TNF-alpha, IL-12 and nitrites accumulation in NOD macrophages while it increased IL-10 production. Nitrites 47-55 vasoactive intestinal polypeptide Mus musculus 0-3 17673149-5 2007 VIP inhibited LPS-induced TNF-alpha, IL-12 and nitrites accumulation in NOD macrophages while it increased IL-10 production. Nitrites 47-55 toll-like receptor 4 Mus musculus 14-17 17673149-7 2007 The inhibitory effect of VIP-induced IL-10 on nitrites was mediated by COX metabolites mostly in NOD cells as indomethacine inhibited both the increase in IL-10 and the reduction of nitrites exerted by VIP. Nitrites 46-54 vasoactive intestinal polypeptide Mus musculus 25-28 17673149-7 2007 The inhibitory effect of VIP-induced IL-10 on nitrites was mediated by COX metabolites mostly in NOD cells as indomethacine inhibited both the increase in IL-10 and the reduction of nitrites exerted by VIP. Nitrites 46-54 interleukin 10 Mus musculus 37-42 17673149-7 2007 The inhibitory effect of VIP-induced IL-10 on nitrites was mediated by COX metabolites mostly in NOD cells as indomethacine inhibited both the increase in IL-10 and the reduction of nitrites exerted by VIP. Nitrites 46-54 interleukin 10 Mus musculus 155-160 17673149-7 2007 The inhibitory effect of VIP-induced IL-10 on nitrites was mediated by COX metabolites mostly in NOD cells as indomethacine inhibited both the increase in IL-10 and the reduction of nitrites exerted by VIP. Nitrites 46-54 vasoactive intestinal polypeptide Mus musculus 202-205 17673149-7 2007 The inhibitory effect of VIP-induced IL-10 on nitrites was mediated by COX metabolites mostly in NOD cells as indomethacine inhibited both the increase in IL-10 and the reduction of nitrites exerted by VIP. Nitrites 182-190 vasoactive intestinal polypeptide Mus musculus 25-28 17673149-7 2007 The inhibitory effect of VIP-induced IL-10 on nitrites was mediated by COX metabolites mostly in NOD cells as indomethacine inhibited both the increase in IL-10 and the reduction of nitrites exerted by VIP. Nitrites 182-190 interleukin 10 Mus musculus 37-42 17673149-7 2007 The inhibitory effect of VIP-induced IL-10 on nitrites was mediated by COX metabolites mostly in NOD cells as indomethacine inhibited both the increase in IL-10 and the reduction of nitrites exerted by VIP. Nitrites 182-190 vasoactive intestinal polypeptide Mus musculus 202-205 17615278-0 2007 A novel method of measuring reduction of nitrite-induced methemoglobin applied to fetal and adult blood of humans and sheep. Nitrites 41-48 hemoglobin subunit gamma 2 Homo sapiens 57-70 17615278-1 2007 The reaction of nitrite with deoxyhemoglobin results in the production of nitric oxide and methemoglobin, a reaction recently proposed as an important oxygen-sensitive source of vasoactive nitric oxide during hypoxic and anoxic stress, with several animal studies suggesting that nitrite may have therapeutic potential. Nitrites 16-23 hemoglobin subunit gamma 2 Homo sapiens 91-104 17615278-1 2007 The reaction of nitrite with deoxyhemoglobin results in the production of nitric oxide and methemoglobin, a reaction recently proposed as an important oxygen-sensitive source of vasoactive nitric oxide during hypoxic and anoxic stress, with several animal studies suggesting that nitrite may have therapeutic potential. Nitrites 280-287 hemoglobin subunit gamma 2 Homo sapiens 91-104 17615278-4 2007 After nitrite-induced production of 20% methemoglobin, the blood was equilibrated with carbon monoxide, which effectively stopped further production. Nitrites 6-13 hemoglobin subunit gamma 2 Homo sapiens 40-53 17615278-8 2007 In conclusion, the novel methodology permits absolute quantification of the reduction of nitrite-induced methemoglobin in whole blood. Nitrites 89-96 hemoglobin subunit gamma 2 Homo sapiens 105-118 18049307-6 2007 Basal, calcium ionophore-stimulated, or interleukin-1 beta-induced NO synthesis was determined by measuring total nitrite in the media. Nitrites 114-121 interleukin 1 beta Rattus norvegicus 40-58 17765919-0 2007 Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. Nitrites 0-7 xanthine dehydrogenase Rattus norvegicus 66-89 17765919-9 2007 Reduction in infarction by nitrite was abolished by the inhibition of flavoprotein reductases and the molybdenum site of xanthine oxidoreductase and was associated with an increase in activity of xanthine dehydrogenase and xanthine oxidase during ischemia. Nitrites 27-34 xanthine dehydrogenase Rattus norvegicus 121-144 17765919-9 2007 Reduction in infarction by nitrite was abolished by the inhibition of flavoprotein reductases and the molybdenum site of xanthine oxidoreductase and was associated with an increase in activity of xanthine dehydrogenase and xanthine oxidase during ischemia. Nitrites 27-34 xanthine dehydrogenase Rattus norvegicus 196-218 17765919-12 2007 Nitrite but not nitrate protects against infarction by a mechanism involving xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. Nitrites 0-7 xanthine dehydrogenase Rattus norvegicus 77-100 17558353-3 2007 We have found that APC suppresses the induction of the potent vasoactive peptide adrenomedullin (ADM) and could downregulate lipopolysaccharide (LPS)-induced ADM messenger RNA (mRNA) and nitrite levels in cell culture. Nitrites 187-194 APC regulator of WNT signaling pathway Homo sapiens 19-22 17614117-6 2007 Residual organics showed little competition with nitrite during short-term chlorination; thus chlorine demand could be predicted by the nitrite residual (5.0 +/- 0.1 mg Cl2 mg NO2(-)-N(-1)). Nitrites 136-143 endogenous retrovirus group W member 5 Homo sapiens 169-172 17658478-2 2007 We investigated the association of -786T/C, -922A/G, 4B/4A, and 894G/T polymorphisms of eNOS with the disease and its impact on nitrite and malonaldehyde levels in 190 COPD patients and 134 healthy controls, all smokers. Nitrites 128-135 nitric oxide synthase 3 Homo sapiens 88-92 17690891-10 2007 TNF-alpha, IL-1beta, IL-6 and nitrite levels decreased after EPO treatment especially in the ipsilateral testis. Nitrites 30-37 erythropoietin Rattus norvegicus 61-64 17697943-2 2007 However, the effects of endothelial nitric oxide synthase (eNOS) gene polymorphisms or haplotypes on the circulating concentrations of nitrite (a sensitive marker of NO formation) and cGMP are unknown. Nitrites 135-142 nitric oxide synthase 3 Homo sapiens 59-63 17682069-6 2007 Mechanistically, nitrite dose-dependently modifies and inhibits complex I by posttranslational S-nitrosation; this dampens electron transfer and effectively reduces reperfusion reactive oxygen species generation and ameliorates oxidative inactivation of complexes II-IV and aconitase, thus preventing mitochondrial permeability transition pore opening and cytochrome c release. Nitrites 17-24 cytochrome c, somatic Homo sapiens 356-368 17678654-9 2007 Addition of S100B to control biopsy specimens resulted in a significant increase of iNOS protein expression and nitrite production. Nitrites 112-119 S100 calcium binding protein B Homo sapiens 12-17 17632098-7 2007 In lipopolysaccharide from Escherichia coli (LPS)-treated RAW 264.7 macrophages, NCX 6560 reduced iNOS expression and dimer assembly more efficiently than atorvastatin and inhibited nitrite accumulation (IC(50)=6.7+/-1.6 microM) and TNFalpha release. Nitrites 182-189 solute carrier family 8 member A1 Rattus norvegicus 81-84 17678654-10 2007 In celiac disease patients but not in controls biopsy specimens, gliadin challenge significantly increased S100B messenger RNA and protein expression, iNOS protein expression, and nitrite production, but these effects were completely inhibited by S100B antibody. Nitrites 180-187 S100 calcium binding protein B Homo sapiens 247-252 17555556-6 2007 Motoneuron survival was inversely correlated with nitrate + nitrite concentrations in mSOD1(G93A) co-cultures, suggesting the important role of nitric oxide in microglia-induced motoneuron injury. Nitrites 60-67 superoxide dismutase 1, soluble Mus musculus 86-91 17914162-9 2007 That is, IL-1beta exposure (100 U/ml) induced a time-dependent decrease in rat insulinoma (RIN) cell viability, which coincided with an induction in iNOS expression and nitrite accumulation. Nitrites 169-176 interleukin 1 beta Rattus norvegicus 9-17 17709521-8 2007 The NOS2 genotype observed in healthy controls was correlated with an increase in NOS2 expression and higher concentrations of nitrate and nitrite in control serum. Nitrites 139-146 nitric oxide synthase 2 Homo sapiens 4-8 17659281-3 2007 This lysine ligation has been previously observed only in the pentaheme nitrite reductases, suggesting that OTR may have a possible role in nitrite reduction. Nitrites 72-79 tetrathionate reductase family octaheme c-type cytochrome Shewanella oneidensis MR-1 108-111 17692543-5 2007 S-Nitrosation of OT dithiol by acidified nitrite at pH 3.0 was examined by absorption spectroscopy and HPLC-UV-MS, which revealed that both singly and doubly S-nitrosated OT are formed. Nitrites 41-48 oxytocin/neurophysin I prepropeptide Homo sapiens 17-19 17692543-5 2007 S-Nitrosation of OT dithiol by acidified nitrite at pH 3.0 was examined by absorption spectroscopy and HPLC-UV-MS, which revealed that both singly and doubly S-nitrosated OT are formed. Nitrites 41-48 oxytocin/neurophysin I prepropeptide Homo sapiens 171-173 17568573-2 2007 Nitrite reduction to NO may be catalyzed by hemoglobin, myoglobin or other metal-containing enzymes and occurs at increasing rates under conditions of physiologic hypoxia or ischemia. Nitrites 0-7 myoglobin Homo sapiens 56-65 17689680-7 2007 RESULTS: IFN-gamma significantly increased nitrite, iNOS protein and iNOS mRNA, and iNOS promoter activation. Nitrites 43-50 interferon gamma Mus musculus 9-18 17347445-8 2007 There was a trend toward enhanced production of nitrate relative to nitrite as an end product of NO metabolism in IL-13-stimulated cells. Nitrites 68-75 interleukin 13 Homo sapiens 114-119 17605605-6 2007 RESULTS: IL-1-GLN-CS and GLN-CS treatments decreased nitrite release, compared with IL-1 treatment; IL-1-GLN-CS treatment decreased IL-1-induced PGE(2) release. Nitrites 53-60 interleukin 1 beta Homo sapiens 9-13 17566055-6 2007 Saccharomyces cerevisiae cells expressing CsNitr1-S absorbed nitrite from an acidic medium at a slower rate than mock-transformed control cells, and accumulated nitrite to only one-sixth the concentration of the control cells, suggesting that CsNitr1-S enhances the efflux of nitrite from the cell. Nitrites 61-68 probable nitrite transporter At1g68570-like Cucumis sativus 42-49 17475504-8 2007 Levels of circulating nitrite/nitrate, the end-metabolites of nitric oxide, were also significantly affected by ACE inhibition, with the same order of potency. Nitrites 22-29 angiotensin I converting enzyme Rattus norvegicus 112-115 17566055-6 2007 Saccharomyces cerevisiae cells expressing CsNitr1-S absorbed nitrite from an acidic medium at a slower rate than mock-transformed control cells, and accumulated nitrite to only one-sixth the concentration of the control cells, suggesting that CsNitr1-S enhances the efflux of nitrite from the cell. Nitrites 161-168 probable nitrite transporter At1g68570-like Cucumis sativus 42-49 17566055-6 2007 Saccharomyces cerevisiae cells expressing CsNitr1-S absorbed nitrite from an acidic medium at a slower rate than mock-transformed control cells, and accumulated nitrite to only one-sixth the concentration of the control cells, suggesting that CsNitr1-S enhances the efflux of nitrite from the cell. Nitrites 161-168 probable nitrite transporter At1g68570-like Cucumis sativus 42-49 17566055-7 2007 Insertion of T-DNA in a single CsNitr1-L homolog (At1g68570) in Arabidopsis resulted in nitrite accumulation in leaves to more than five times the concentration found in the wild type. Nitrites 88-95 probable nitrite transporter At1g68570-like Cucumis sativus 31-38 17566055-9 2007 CsNitr1-L may possibly load cytosolic nitrite into chloroplast stroma in the chloroplast envelope during nitrate assimilation. Nitrites 38-45 probable nitrite transporter At1g68570-like Cucumis sativus 0-7 17566055-10 2007 The presence of genes homologous to CsNitr1-L in the genomes of Arabidopsis and rice indicates that facilitated nitrite transport is of general physiological importance in plant nutrition. Nitrites 112-119 probable nitrite transporter At1g68570-like Cucumis sativus 36-43 17530864-5 2007 Nitrite ion rapidly accumulated in the extracellular medium over a period of 5-8 h post-activation in both cell lines, indicating the presence of active nitric oxide synthase (iNOS) during that period. Nitrites 0-7 nitric oxide synthase 2, inducible Mus musculus 176-180 17495223-4 2007 The NO generated by reaction of deoxygenated Mb with nitrite is functionally relevant and leads to a downregulation of cardiac energy status, which was not observed in mice lacking Mb. Nitrites 53-60 myoglobin Mus musculus 45-47 17495223-4 2007 The NO generated by reaction of deoxygenated Mb with nitrite is functionally relevant and leads to a downregulation of cardiac energy status, which was not observed in mice lacking Mb. Nitrites 53-60 myoglobin Mus musculus 181-183 17277235-7 2007 We evaluated the interaction of processed meat and nitrate plus nitrite intake with CYP2A6 activity, an enzyme able to metabolize some NOC to their carcinogenic form. Nitrites 64-71 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 84-90 17532345-10 2007 Treating RAW 264.7 macrophages with a PPARgamma antagonist resulted in defective ROS production in response to LPS, however, stimulated nitrite production was unaltered. Nitrites 136-143 peroxisome proliferator-activated receptor gamma Rattus norvegicus 38-47 17554176-1 2007 The periplasmic nitrate reductase from Cupriavidus necator (also known as Ralstonia eutropha) is a heterodimer that is able to reduce nitrate to nitrite. Nitrites 145-152 H16_RS30030 Ralstonia eutropha H16 16-33 17277235-7 2007 We evaluated the interaction of processed meat and nitrate plus nitrite intake with CYP2A6 activity, an enzyme able to metabolize some NOC to their carcinogenic form. Nitrites 64-71 nocturnin Homo sapiens 135-138 17336418-8 2007 PPT/DPN reduced nitrate/nitrite production and iNOS mRNA in Kupffer cells following trauma-hemorrhage; however, these levels in DPN-treated animals remained higher than sham. Nitrites 24-31 tachykinin, precursor 1 Rattus norvegicus 0-3 17470727-9 2007 ERalpha activation had the most potent effects on both nitrite formation and inhibiting O(2)(-) (P<0.05). Nitrites 55-62 estrogen receptor 1 Homo sapiens 0-7 17471586-6 2007 RESULTS: Transfection of the hOC/iNOS plasmid increased iNOS protein and total nitrite levels in PC3 and DU145 cells, but not LNCaP or HT29. Nitrites 79-86 nitric oxide synthase 2 Homo sapiens 33-37 17407761-5 2007 Here, we report for the first time on the use of lentiviral vector-based shRNA delivery to efficiently suppress the IL-1beta-mediated induction of iNOS expression, the accumulation of nitrite and provide significant protection against the cytotoxic effects of IL-1beta exposure. Nitrites 184-191 interleukin 1 beta Homo sapiens 116-124 17471586-6 2007 RESULTS: Transfection of the hOC/iNOS plasmid increased iNOS protein and total nitrite levels in PC3 and DU145 cells, but not LNCaP or HT29. Nitrites 79-86 chromobox 8 Homo sapiens 97-100 17548042-4 2007 As compared with wild-type mice, the increases in the plasma NO level measured as nitrite and nitrate and hepatic iNOS were significantly reduced in IL-1alpha/beta(-/-) and TNFalpha(-/-) mice 8 and 12h after the LPS challenge. Nitrites 82-89 interleukin 1 alpha Mus musculus 149-158 17548042-4 2007 As compared with wild-type mice, the increases in the plasma NO level measured as nitrite and nitrate and hepatic iNOS were significantly reduced in IL-1alpha/beta(-/-) and TNFalpha(-/-) mice 8 and 12h after the LPS challenge. Nitrites 82-89 tumor necrosis factor Mus musculus 173-181 17237253-11 2007 Nitrite production in response to the ACE inhibitors was greater in microvessels from SWOP. Nitrites 0-7 angiotensin I converting enzyme Canis lupus familiaris 38-41 17447754-9 2007 In this case, a very unusual binding mode is observed where one nitrite is eta1-O and the other one is eta1-N bound. Nitrites 64-71 secreted phosphoprotein 1 Homo sapiens 75-79 17447754-9 2007 In this case, a very unusual binding mode is observed where one nitrite is eta1-O and the other one is eta1-N bound. Nitrites 64-71 secreted phosphoprotein 1 Homo sapiens 103-107 17447754-13 2007 Finally, using a bidentate neutral bis(pyrazolyl)methane ligand, two eta1-O coordinated nitrite ligands are observed. Nitrites 88-95 secreted phosphoprotein 1 Homo sapiens 69-73 17229473-6 2007 Moreover, leptin increased plasma concentration and urinary excretion of NO metabolites, nitrites+nitrates (NO(x)), and of NO second messenger, cyclic GMP. Nitrites 89-97 leptin Rattus norvegicus 10-16 17237253-8 2007 Nitrite production in response to carbachol, bradykinin, and A23187 was also enhanced in microvessels from SWOP (P < 0.05). Nitrites 0-7 kininogen 1 Canis lupus familiaris 45-55 17306574-2 2007 We evaluated the association of eNOS genotypes/haplotypes with the plasma concentrations of nitrite/nitrate (NO(x)), which are products of nitric oxide in HT, T2DM, and T2DM+HT patients. Nitrites 92-99 nitric oxide synthase 3 Homo sapiens 32-36 17457174-10 2007 Interestingly, inhibition of IFN-gamma in CpG-treated animals reduced TNF-alpha (P < 0.05), IL-6 (P < 0.05), nitrite (P < 0.05), and intestinal permeability following hemorrhagic shock (P < 0.05) and down-regulated expression of TLR4. Nitrites 115-122 interferon gamma Rattus norvegicus 29-38 17578710-5 2007 Homocysteine did not affect basal nitrite accumulation; however, it significantly increased the nitrite accumulation induced by the calcium ionophore A23187 or interleukin-1beta only at 1 mM. Nitrites 96-103 interleukin 1 beta Rattus norvegicus 160-177 17094870-3 2007 Here, we investigated whether NOS2-mediated nitrite/nitrate synthesis modulates responsiveness to inhaled NO. Nitrites 44-51 nitric oxide synthase 2 Rattus norvegicus 30-34 17322300-2 2007 Nitrite reacts with deoxyhemoglobin in an allosteric reaction that generates NO and oxidizes deoxyhemoglobin to methemoglobin. Nitrites 0-7 hemoglobin subunit gamma 2 Homo sapiens 112-125 17696737-2 2007 The aim of the present study was to quantify nitrate+nitrite (NO2+NO3) in tobacco products as well as to study tobacco exposure related biomarkers in controls, patients with oral precancers (OPC) and oral cancer patients. Nitrites 53-60 NBL1, DAN family BMP antagonist Homo sapiens 66-69 17094870-11 2007 Here, responsiveness to inhaled NO is dependent on the ability of NOS2 inhibitors to reduce nitrite and nitrate levels in serum and released in the lung. Nitrites 92-99 nitric oxide synthase 2 Rattus norvegicus 66-70 17242981-4 2007 Using the hph-1 mouse, which displays a partial BH4 deficiency owing to impaired activity of GTP cyclohydrolase, we report decreased levels of glutathione in brain and kidney and evidence for decreased basal generation of nitric oxide in the periphery (as judged by the plasma nitrate plus nitrite concentration). Nitrites 290-297 hyperphenylalaninemia 1 Mus musculus 10-15 17242981-6 2007 However, the concentration of plasma nitrate plus nitrite achieved was significantly decreased in the hph-1 mouse. Nitrites 50-57 hyperphenylalaninemia 1 Mus musculus 102-107 17169333-0 2007 Multidrug resistance related protein (ABCC1) and its role on nitrite production by the murine macrophage cell line RAW 264.7. Nitrites 61-68 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 38-43 17241650-11 2007 Moreover, incubation with 3 microg/ml F32, 30 microg/ml TAE, F29/30, F31/33 or F34/35 induced accumulation of nitrite in culture medium indicating induction of NO production. Nitrites 110-117 N-acetyltransferase domain containing 1 Mus musculus 38-41 17241650-11 2007 Moreover, incubation with 3 microg/ml F32, 30 microg/ml TAE, F29/30, F31/33 or F34/35 induced accumulation of nitrite in culture medium indicating induction of NO production. Nitrites 110-117 mitogen-activated protein kinase kinase 3, opposite strand Mus musculus 69-72 17082222-12 2007 Nitrite administrated luminally in endothelial nitric oxide synthase-deficient mice increased mucosal blood flow. Nitrites 0-7 nitric oxide synthase 3, endothelial cell Mus musculus 35-68 17169333-8 2007 ABCC1 inhibition by indomethacin, probenecid or MK571 decreased LPS induced nitrite production in a concentration-dependent manner, the same result was observed with BSO and again GSH reversed its effect. Nitrites 76-83 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 0-5 17169333-10 2007 In conclusion, LPS modulated the expression and activity of ABCC1 transporters in RAW macrophages and inhibitors of these transporters were capable of inhibiting nitrite production suggesting a role for ABCC1 transporters in the inflammatory process. Nitrites 162-169 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 60-65 17169333-10 2007 In conclusion, LPS modulated the expression and activity of ABCC1 transporters in RAW macrophages and inhibitors of these transporters were capable of inhibiting nitrite production suggesting a role for ABCC1 transporters in the inflammatory process. Nitrites 162-169 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 203-208 17633643-4 2007 The denitrification system played an important role in preventing nitrite inhibition of DNT biodegradation, but it was necessary to supply an additional carbon source to ensure complete nitrite removal. Nitrites 66-73 5', 3'-nucleotidase, cytosolic Homo sapiens 88-91 16816886-5 2007 There was a positive correlation between serum leptin and total nitrite levels (r=0.65, p<0.001). Nitrites 64-71 leptin Homo sapiens 47-53 17056288-5 2007 An aliquot of conditioned culture media was first treated with nitrate reductase, NADPH, glucose-6-phosphate dehydrogenase and glucose-6-phosphate to convert nitrate to nitrite quantitatively. Nitrites 169-176 glucose-6-phosphate dehydrogenase Homo sapiens 89-122 17364963-1 2007 Production of nitrogen dioxide by the activity of myeloperoxidase (MPO) in the presence of nitrite is now considered a key step in the pathophysiology of low-density lipoprotein (LDL) oxidation. Nitrites 91-98 myeloperoxidase Homo sapiens 50-65 17364963-1 2007 Production of nitrogen dioxide by the activity of myeloperoxidase (MPO) in the presence of nitrite is now considered a key step in the pathophysiology of low-density lipoprotein (LDL) oxidation. Nitrites 91-98 myeloperoxidase Homo sapiens 67-70 17364963-2 2007 This study shows that betanin, a phytochemical of the betalain class, inhibits the production of lipid hydroperoxides in human LDL submitted to a MPO/nitrite-induced oxidation. Nitrites 150-157 myeloperoxidase Homo sapiens 146-149 17364963-5 2007 In addition, unidentified oxidation product(s) of betanin by MPO/nitrite inhibit(s) the MPO/nitrite-induced LDL oxidation as effectively as the parent compound. Nitrites 65-72 myeloperoxidase Homo sapiens 88-91 17364963-5 2007 In addition, unidentified oxidation product(s) of betanin by MPO/nitrite inhibit(s) the MPO/nitrite-induced LDL oxidation as effectively as the parent compound. Nitrites 92-99 myeloperoxidase Homo sapiens 61-64 17364963-5 2007 In addition, unidentified oxidation product(s) of betanin by MPO/nitrite inhibit(s) the MPO/nitrite-induced LDL oxidation as effectively as the parent compound. Nitrites 92-99 myeloperoxidase Homo sapiens 88-91 17250799-4 2007 The pseudoperoxidase activity of lactoperoxidase increased lipid peroxidation, while thiocyanate and nitrite-reduced lipid peroxidation. Nitrites 101-108 lactoperoxidase Homo sapiens 33-48 16859981-4 2007 Reaction and determination acidity for nitrite is the same which made the method much simpler compared with the widely accepted fluorescence method with DAN as a fluorescence reagent. Nitrites 39-46 NBL1, DAN family BMP antagonist Homo sapiens 153-156 17202421-0 2007 Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase. Nitrites 0-7 xanthine dehydrogenase Rattus norvegicus 107-130 17117376-2 2007 Using angiotensin II as the model system, we demonstrate that nitrite catalyzed the selective iodination of the peptide at the N-terminus in an acidic solution. Nitrites 62-69 angiotensinogen Homo sapiens 6-20 17202421-7 2007 Renal tissue homogenates produced significant amounts of NO from nitrite, an effect that was attenuated significantly by the xanthine oxidoreductase inhibitor allopurinol. Nitrites 65-72 xanthine dehydrogenase Rattus norvegicus 125-148 17300995-4 2007 Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA. Nitrites 95-102 heme oxygenase 1 Mus musculus 14-18 17300995-4 2007 Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA. Nitrites 95-102 ATPase, class II, type 9A Mus musculus 130-133 17160351-3 2007 The anoxic release of NO is mediated by endothelial nitric oxide synthase (eNOS), can be abolished by inhibitors of NOS and is accompanied by consumption of intracellular nitrite. Nitrites 171-178 nitric oxide synthase 3, endothelial cell Mus musculus 75-79 17160351-5 2007 The phenomenon is attributed to anoxic reduction of intracellular nitrite by eNOS, and its magnitude and duration suggests that the nitrite reductase activity of eNOS is relevant for fast NO delivery in hypoxic vascular tissues. Nitrites 66-73 nitric oxide synthase 3, endothelial cell Mus musculus 77-81 17160351-5 2007 The phenomenon is attributed to anoxic reduction of intracellular nitrite by eNOS, and its magnitude and duration suggests that the nitrite reductase activity of eNOS is relevant for fast NO delivery in hypoxic vascular tissues. Nitrites 66-73 nitric oxide synthase 3, endothelial cell Mus musculus 162-166 17056198-5 2006 This caused up to 2.1-fold radiosensitization of EMT-6 tumor cells, which was associated with the iNOS-mediated production of the radiosensitizing molecule nitric oxide, as confirmed by accumulation of its oxidative metabolite nitrite, Western blot analysis, and reverse transcriptase-polymerase chain reaction. Nitrites 227-234 nitric oxide synthase 2, inducible Mus musculus 98-102 17393066-1 2007 The study aimed to assay the cerebrospinal fluid (CSF) levels of protein S100B, a biomarker of astrocyte activation in relation to kynurenic acid (KYNA) and nitric oxide (NO) metabolites, nitrate/nitrite (NOx) concentrations in acute relapse multiple sclerosis (MS) patients. Nitrites 196-203 S100 calcium binding protein B Homo sapiens 73-78 17192887-7 2007 DMH-induced increases in the total nitrite/nitrate levels and the nitric oxide synthase (NOS) activity (n = 10-12, P < 0.05) were also reduced in the DMH + GM-CSF group (n = 8-9, P < 0.05). Nitrites 35-42 colony stimulating factor 2 Rattus norvegicus 159-165 17564365-6 2007 In order to model the nitrite accumulation observed, the ASM1 model was extended with a two-step nitrification and denitrification including nitrite as intermediate. Nitrites 22-29 H19 imprinted maternally expressed transcript Homo sapiens 57-61 17564365-6 2007 In order to model the nitrite accumulation observed, the ASM1 model was extended with a two-step nitrification and denitrification including nitrite as intermediate. Nitrites 141-148 H19 imprinted maternally expressed transcript Homo sapiens 57-61 17041163-4 2006 The current study now reveals that the resistance phenotype of C-cpe isolates extends beyond temperature resistance to also include, for both vegetative cells and spores, enhanced resistance to osmotic stress (from NaCl) and nitrites. Nitrites 225-233 cpe Clostridium perfringens 65-68 17723778-2 2006 The Co(II) signal was enhanced by exploitation of the catalytic process in the presence of nitrite. Nitrites 91-98 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-10 17109653-8 2006 prevented hypertension-induced attenuation of acetylcholine-induced endothelium-dependent relaxation, impairment of vascular endothelial lining, decrease in expression of mRNA for endothelial nitric oxide synthase (eNOS), serum nitrite/nitrate concentration and increase in expression of mRNA for p22phox, superoxide anion and serum TBARS. Nitrites 228-235 nitric oxide synthase 3 Rattus norvegicus 215-219 17010309-7 2006 The inhibition by ANP of the LPS-induced nitrite response was abrogated by a NP-receptor antagonist, HS-142-1 (100 ng/ml). Nitrites 41-48 natriuretic peptide A Rattus norvegicus 18-21 17023389-3 2006 We created mouse embryo fibroblast (MEF) cell lines that would facilitate investigation of the effect of mPGES-1 genetic deletion on prostanoid biosynthesis in fibroblast lineage cells and its subsequent effect on the expression of inducible NOS (iNOS) and nitrite biosynthesis using cells derived from mPGES-1 wild-type (WT), heterozygous (Het), and null mice. Nitrites 257-264 nitric oxide synthase 2, inducible Mus musculus 232-245 16963453-5 2006 This was illustrated by the fact that engagement of beta2 integrins increased the production of nitrite, a stable end-product of nitric oxide. Nitrites 96-103 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 52-57 17073484-11 2006 The results were interpreted in terms of the mechanisms that the charge separation of an incorporated Ru(II) complex took place to produce a pair of a Ru(III) complex and an electron and that the generated Ru(III) complex was reduced by a nitrite ion before it recombined with the electron. Nitrites 239-246 mitochondrially encoded cytochrome c oxidase III Homo sapiens 154-157 17073484-11 2006 The results were interpreted in terms of the mechanisms that the charge separation of an incorporated Ru(II) complex took place to produce a pair of a Ru(III) complex and an electron and that the generated Ru(III) complex was reduced by a nitrite ion before it recombined with the electron. Nitrites 239-246 mitochondrially encoded cytochrome c oxidase III Homo sapiens 209-212 17023389-6 2006 In addition, we show that mPGES-1 gene deletion and subsequent decrease in PGE2 levels results in a differential induction profile of iNOS and nitrite levels (the stable breakdown product of nitric oxide (NO) in mPGES-1 WT MEFs compared with null MEFs. Nitrites 143-150 prostaglandin E synthase Mus musculus 26-33 17043238-8 2006 Compared with wild-type microglia, mSOD1(G93A) microglia produced and released more superoxide and nitrite+nitrate, and induced more neuronal death. Nitrites 99-106 superoxide dismutase 1, soluble Mus musculus 35-40 17023389-6 2006 In addition, we show that mPGES-1 gene deletion and subsequent decrease in PGE2 levels results in a differential induction profile of iNOS and nitrite levels (the stable breakdown product of nitric oxide (NO) in mPGES-1 WT MEFs compared with null MEFs. Nitrites 143-150 prostaglandin E synthase Mus musculus 212-219 17345786-12 2006 Olmesartan significantly improved cardiovascular remodeling and cardiac nitrite/ nitrate content, but co-administration of olmesartan and (D-Ala7)-Ang-(1-7) partially reversed this anti-remodeling effect and the increase in nitrite/nitrate. Nitrites 72-79 angiogenin Rattus norvegicus 147-155 17345786-12 2006 Olmesartan significantly improved cardiovascular remodeling and cardiac nitrite/ nitrate content, but co-administration of olmesartan and (D-Ala7)-Ang-(1-7) partially reversed this anti-remodeling effect and the increase in nitrite/nitrate. Nitrites 224-231 angiogenin Rattus norvegicus 147-155 17071778-5 2006 These inhibitory effects were confirmed by in vitro studies, where the presence of leptin reduced the concentrations of progesterone, PGE and nitrites in the media of both ovarian explants and preovulatory follicle cultures. Nitrites 142-150 leptin Rattus norvegicus 83-89 16952382-8 2006 Moreover, hCG increased nitrate uptake into MLTC-1, which suggests the gonadotropin aids nitrite and nitrate ions in their steroidogenesis inhibitory activity. Nitrites 89-96 hypertrichosis 2 (generalised, congenital) Homo sapiens 10-13 17055381-1 2006 The mitochondrial aldehyde dehydrogenase (ALDH2, mtALDH) was recently found to catalyze the reduction of nitroglycerin (glyceryl trinitrate [GTN]) to generate nitrite and 1,2-glyceryl dinitrate. Nitrites 159-166 aldehyde dehydrogenase 2, mitochondrial Mus musculus 42-47 17029353-4 2006 The shift to higher frequency of the Raman bands of the type 1 copper center with the addition of nitrite ions suggests a stronger Cu-S(Cys) interaction in the substrate-bound A. xylosoxidans nitrite reductase. Nitrites 98-105 nitrite reductase large subunit Achromobacter xylosoxidans 192-209 16968407-5 2006 In this context, we hypothesize that IL-10, through its ability to inhibit anti-leishmanial macrophage activation, associated with the lower frequency of TNF-alpha(+) monocytes and ordinary levels of nitrite and nitrate are the major mechanisms associated with disease onset. Nitrites 200-207 interleukin 10 Homo sapiens 37-42 16962929-0 2006 eNOS gene T-786C polymorphism modulates atorvastatin-induced increase in blood nitrite. Nitrites 79-86 nitric oxide synthase 3 Homo sapiens 0-4 17032626-7 2006 A positive correlation between NOx (nitrites and nitrates levels) and VEGF was found in healthy individuals (r = 0.55, p = 0.003), but there was no correlation in hypertensive patients. Nitrites 36-44 vascular endothelial growth factor A Homo sapiens 70-74 16962939-0 2006 Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio. Nitrites 32-39 myeloperoxidase Homo sapiens 16-31 16933320-7 2006 Up-regulation of iNOS led to increased generation of NO as reflected by elevated nitrite levels (an end product of NO metabolism). Nitrites 81-88 nitric oxide synthase 2 Rattus norvegicus 17-21 18970764-0 2006 Simultaneous determination of nitrite and nitrate in dew, rain, snow and lake water samples by ion-pair high-performance liquid chromatography. Nitrites 30-37 Ras interacting protein 1 Homo sapiens 58-62 16905358-2 2006 The first known member Nar1.1 encodes a chloroplast nitrite transporter that regulates nitrate assimilation according to carbon availability, and data supporting the idea that NAR1 proteins may participate in adjusting both nitrite and carbon utilization by Chlamydomonas cells are presented herein. Nitrites 52-59 NAR1.1 Chlamydomonas reinhardtii 23-29 18970764-6 2006 This method was applied for the simultaneous determination of nitrite and nitrate in dew, rain, snow and lake water samples collected in southeast Massachusetts. Nitrites 62-69 Ras interacting protein 1 Homo sapiens 90-94 18970764-8 2006 Nitrite was only a minor species in dew (0.62-0.83mug/mL), rain (<0.005-0.14mug/mL), snow (0.021-0.032mug/mL) and lake water (0.12-0.16mug/mL). Nitrites 0-7 Ras interacting protein 1 Homo sapiens 59-63 17031261-5 2006 Urinary excretion of nitrite was lower in the aging rats (P < 0.05), and this was associated with reduced nitric oxide synthase (NOS) activity and reduced eNOS and iNOS protein expression in the aorta. Nitrites 21-28 nitric oxide synthase 2 Rattus norvegicus 167-171 16846834-10 2006 COX-2 was not modified, but iNOS protein was significantly reduced accompanied by a diminished nitrite production, in a dose-dependent manner, in comparison to the TNBS group. Nitrites 95-102 nitric oxide synthase 2 Rattus norvegicus 28-32 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. Nitrites 152-159 insulin like growth factor 1 Homo sapiens 182-187 17003285-2 2006 LPS decreased IGF-I mRNA in hepatocyte cultures and increased the nitrite + nitrate levels in the culture medium. Nitrites 66-73 interferon regulatory factor 6 Homo sapiens 0-3 17003285-8 2006 However, in cocultures, the iNOS inhibitor l-NIL prevented the effect of LPS on nitrite+nitrate levels, but only attenuated the LPS-induced decrease in IGF-I gene expression. Nitrites 80-87 nitric oxide synthase 2 Homo sapiens 28-32 17003285-3 2006 Furthermore, there was a negative correlation between the IGF-I mRNA and the nitrite+nitrate levels. Nitrites 77-84 insulin like growth factor 1 Homo sapiens 58-63 17003285-8 2006 However, in cocultures, the iNOS inhibitor l-NIL prevented the effect of LPS on nitrite+nitrate levels, but only attenuated the LPS-induced decrease in IGF-I gene expression. Nitrites 80-87 interferon regulatory factor 6 Homo sapiens 73-76 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. Nitrites 152-159 nitric oxide synthase 2 Homo sapiens 26-47 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. Nitrites 152-159 nitric oxide synthase 2 Homo sapiens 49-53 16647868-7 2006 We also show that NO2* radicals, generated by a myeloperoxidase/H2O2/nitrite system, also degrade DMPO/HO*. Nitrites 69-76 myeloperoxidase Homo sapiens 48-63 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. Nitrites 152-159 interferon regulatory factor 6 Homo sapiens 145-148 18040808-0 2006 Effects of inhalant nitrites on VEGF expression: a feasible link to Kaposi"s sarcoma? Nitrites 20-28 vascular endothelial growth factor A Homo sapiens 32-36 18040808-6 2006 The in vivo growth rate of a subcutaneous VEGF-responsive tumor was also shown to be accelerated by inhalant nitrite exposure. Nitrites 109-116 vascular endothelial growth factor A Homo sapiens 42-46 18040808-7 2006 Because the development of KS is extensively linked to VEGF and its receptors, the purported link between inhalant nitrites and KS may be explained mechanistically, at least in part, through the stimulation of VEGF expression by these inhalants. Nitrites 115-123 vascular endothelial growth factor A Homo sapiens 55-59 18040808-7 2006 Because the development of KS is extensively linked to VEGF and its receptors, the purported link between inhalant nitrites and KS may be explained mechanistically, at least in part, through the stimulation of VEGF expression by these inhalants. Nitrites 115-123 vascular endothelial growth factor A Homo sapiens 210-214 16906150-4 2006 We therefore hypothesized that the multicopper oxidase, ceruloplasmin, could oxidize NO to NO+, with subsequent hydration to nitrite. Nitrites 125-132 ceruloplasmin Mus musculus 56-69 16906150-6 2006 Compared to controls, plasma nitrite concentrations were substantially reduced in ceruloplasmin knockout mice, which were more susceptible to liver infarction after ischemia and reperfusion. Nitrites 29-36 ceruloplasmin Mus musculus 82-95 16904722-11 2006 Nitro-group of PNP converted to nitrite and nitrate. Nitrites 32-39 purine nucleoside phosphorylase Homo sapiens 15-18 16937444-7 2006 In addition, L-NAME was able to inhibit the GH-effects on intracellular cAMP concentration under basal conditions and in response to CT. GH induced a Ca(2+)-dependent increase of nitrites/nitrates production, indicating the involvement of the constitutive rather than the inducible NOS isoform, which was directly confirmed by Western blot analysis. Nitrites 179-187 growth hormone 1 Homo sapiens 44-46 16863986-2 2006 These difficulties result from oxidation of nitrite (within minutes) by heme proteins, such as hemoglobin, myoglobin, cytoglobin, and neuroglobin; its low levels in vivo; and its ubiquitous presence in laboratory buffers and glassware. Nitrites 44-51 cytoglobin Homo sapiens 118-128 16863986-2 2006 These difficulties result from oxidation of nitrite (within minutes) by heme proteins, such as hemoglobin, myoglobin, cytoglobin, and neuroglobin; its low levels in vivo; and its ubiquitous presence in laboratory buffers and glassware. Nitrites 44-51 neuroglobin Homo sapiens 134-145 16937444-7 2006 In addition, L-NAME was able to inhibit the GH-effects on intracellular cAMP concentration under basal conditions and in response to CT. GH induced a Ca(2+)-dependent increase of nitrites/nitrates production, indicating the involvement of the constitutive rather than the inducible NOS isoform, which was directly confirmed by Western blot analysis. Nitrites 179-187 growth hormone 1 Homo sapiens 137-139 16376593-10 2006 Neutrophil nitrite was correlated with SOD activity and iNOS levels, but not in lymphocytes. Nitrites 11-18 nitric oxide synthase 2 Homo sapiens 56-60 16918246-7 2006 Superoxide dismutase (SOD) enhanced nitrite- and NOR 3-induced fluorescence increase in the bacterial fraction, and the degree of the enhancement decreased as the concentrations of nitrite and NOR 3 were increased. Nitrites 36-43 superoxide dismutase 1 Homo sapiens 0-20 16918246-7 2006 Superoxide dismutase (SOD) enhanced nitrite- and NOR 3-induced fluorescence increase in the bacterial fraction, and the degree of the enhancement decreased as the concentrations of nitrite and NOR 3 were increased. Nitrites 36-43 superoxide dismutase 1 Homo sapiens 22-25 16918246-7 2006 Superoxide dismutase (SOD) enhanced nitrite- and NOR 3-induced fluorescence increase in the bacterial fraction, and the degree of the enhancement decreased as the concentrations of nitrite and NOR 3 were increased. Nitrites 181-188 superoxide dismutase 1 Homo sapiens 0-20 16918246-7 2006 Superoxide dismutase (SOD) enhanced nitrite- and NOR 3-induced fluorescence increase in the bacterial fraction, and the degree of the enhancement decreased as the concentrations of nitrite and NOR 3 were increased. Nitrites 181-188 superoxide dismutase 1 Homo sapiens 22-25 16413208-0 2006 Dietary administration of bovine lactoferrin influences the immune ability of the giant freshwater prawn Macrobrachium rosenbergii (de Man) and its resistance against Aeromonas hydrophila infection and nitrite stress. Nitrites 202-209 lactotransferrin Bos taurus 33-44 16691532-15 2006 Animals receiving both L- NAME and aminoguanidine (AG), an inducible nitric oxide synthase (iNOS) inhibitor (65 mg/Kg body weight/day, orally), showed significant decrease in the nitrite serum levels, sympathetic denervation and macrophage infiltration at day 7. Nitrites 179-186 nitric oxide synthase 2 Rattus norvegicus 59-90 16691532-15 2006 Animals receiving both L- NAME and aminoguanidine (AG), an inducible nitric oxide synthase (iNOS) inhibitor (65 mg/Kg body weight/day, orally), showed significant decrease in the nitrite serum levels, sympathetic denervation and macrophage infiltration at day 7. Nitrites 179-186 nitric oxide synthase 2 Rattus norvegicus 92-96 16434229-3 2006 Comparing with the calculated energies, it can be concluded that the syn conformers with Cs overall symmetry, a planar CC(O)ONO skeleton in nitrites, and a planar CC(O)ON skeleton in nitrates, respectively, are the most stable in the gas phase. Nitrites 140-148 synemin Homo sapiens 69-72 16910783-1 2006 Nitrite (NO(2)-), N (G)-hydroxy-L-arginine (NOHA), and hydroxylamine (NH(2)OH) are products of nitric oxide synthase (NOS) activity and can also be formed by secondary reactions of nitric oxide (NO). Nitrites 0-7 nitric oxide synthase 2 Homo sapiens 95-116 16705756-4 2006 Nitrite plus nitrate levels were lower in iNOS(-/-) compared with iNOS(+/+) mice, but CCl(4) did not produce a significant effect in any mice. Nitrites 0-7 nitric oxide synthase 2, inducible Mus musculus 42-46 16473374-3 2006 During our study, we investigated the effects of azathioprine on the inducible nitric oxide synthase (iNOS) in lipopolysaccharide stimulated murine macrophages (RAW 264.7) by measurement of iNOS protein (immunoblotting), iNOS mRNA (semiquantitative competitive RT-PCR), and NO production (nitrite levels). Nitrites 289-296 nitric oxide synthase 2, inducible Mus musculus 102-106 16696940-6 2006 Nitrite increase was blocked by L-NAME and 1400W indicating the participation of the inducible Nitric Oxide Synthase (iNOS). Nitrites 0-7 nitric oxide synthase 2 Rattus norvegicus 85-116 16696940-6 2006 Nitrite increase was blocked by L-NAME and 1400W indicating the participation of the inducible Nitric Oxide Synthase (iNOS). Nitrites 0-7 nitric oxide synthase 2 Rattus norvegicus 118-122 16741643-5 2006 RESULTS: The vascular endothelial growth factor (mean, 220.6 pg/ml, P < 0.005) and nitrite (mean, 29.4 microM, P = 0.043) levels of patients with cancer were significantly higher than those of controls (mean vascular endothelial growth factor, 67 pg/ml; mean nitrite, 23 microM). Nitrites 262-269 vascular endothelial growth factor A Homo sapiens 13-47 16713667-8 2006 Similarly, levels of iNOS expression and nitrite formation were significantly lower in normal human lung epithelial cells treated with PQ and NAC than PQ-treated alone cells. Nitrites 41-48 X-linked Kx blood group Homo sapiens 142-145 16288974-6 2006 Follow-up studies in the liver revealed significant nitrite-induced expression of VEGF protein and mRNA. Nitrites 52-59 vascular endothelial growth factor A Mus musculus 82-86 16955242-6 2006 RESULTS: In cultured synoviocytes, SP, TNF-alpha and IL-1beta induced significantly increased nitrite concentrations. Nitrites 94-101 tachykinin 1 Mus musculus 35-37 16955242-6 2006 RESULTS: In cultured synoviocytes, SP, TNF-alpha and IL-1beta induced significantly increased nitrite concentrations. Nitrites 94-101 tumor necrosis factor Mus musculus 39-48 16955242-6 2006 RESULTS: In cultured synoviocytes, SP, TNF-alpha and IL-1beta induced significantly increased nitrite concentrations. Nitrites 94-101 interleukin 1 beta Mus musculus 53-61 16839461-6 2006 EPO at 100 IU/kg increased nitrite, and at 1,000 IU/kg it raised cAMP. Nitrites 27-34 erythropoietin Rattus norvegicus 0-3 16288974-9 2006 In conclusion, multiple exposures to inhalant nitrite appeared to cause alteration in the expression of a number of genes relating to cancer and angiogenesis, including VEGF. Nitrites 46-53 vascular endothelial growth factor A Mus musculus 169-173 16914097-7 2006 Our in vitro results indicate a correlation between nitrite and IFN-gamma production in PBMC culture supernatants. Nitrites 52-59 interferon gamma Homo sapiens 64-73 16490313-4 2006 Stimulation of differentiated PC12 cells with Abeta (1-42) (1 microg/mL) for 36 h caused a significant increase of nitrite production, compared to un-stimulated cells, that was inhibited in a concentration-dependent manner by both the non-selective iNOS inhibitor, L-NAME (0.3-30 microM), and, at higher extent, by the selective iNOS inhibitor SMT (0.3-30 microM). Nitrites 115-122 nitric oxide synthase 2 Rattus norvegicus 249-253 16490313-4 2006 Stimulation of differentiated PC12 cells with Abeta (1-42) (1 microg/mL) for 36 h caused a significant increase of nitrite production, compared to un-stimulated cells, that was inhibited in a concentration-dependent manner by both the non-selective iNOS inhibitor, L-NAME (0.3-30 microM), and, at higher extent, by the selective iNOS inhibitor SMT (0.3-30 microM). Nitrites 115-122 nitric oxide synthase 2 Rattus norvegicus 329-333 16527817-7 2006 Therefore, CPR catalyzes organic nitrate reduction, producing nitrite, whereas CP can mediate further nitrite reduction to NO. Nitrites 62-69 cytochrome p450 oxidoreductase Homo sapiens 11-14 16670299-2 2006 Th1-type cytokines induce NO synthase 2, which metabolizes arginine into nitrites, while the Th2-type cytokines produce arginase, which converts arginine into polyamines and proline. Nitrites 73-81 negative elongation factor complex member C/D, Th1l Mus musculus 0-3 16527817-8 2006 Nitrite-dependent NO generation contributed <10% of the CPR-CP-mediated NO generation from organic nitrates; thus, NO2(-) is not the main precursor of NO. Nitrites 0-7 cytochrome p450 oxidoreductase Rattus norvegicus 59-62 16527817-10 2006 Studies suggested that organic nitrite (R-O-NO) was produced from organic nitrate reduction by CPR. Nitrites 31-38 cytochrome p450 oxidoreductase Homo sapiens 95-98 16636306-5 2006 Treatment with two structurally dissimilar iNOS inhibitors at doses sufficient to decrease urine nitrate and/or nitrite exacerbated proteinuria. Nitrites 112-119 nitric oxide synthase 2 Rattus norvegicus 43-47 16771678-4 2006 Neuronal NOS2 was assessed by increases in nitrite accumulation, and increases in NOS2 mRNA levels and fluorescence of the NO-sensitive probe DAF-2 DA. Nitrites 43-50 nitric oxide synthase 2, inducible Mus musculus 9-13 16771679-9 2006 Reduced nitrite release persisted in spite of normal responsiveness to inflammatory stimulation as measured by tumor necrosis factor alpha and interleukin-6 production and release. Nitrites 8-15 interleukin 6 Mus musculus 143-156 16771679-10 2006 These data suggest that the human-specific release of nanomolar levels of nitrite may largely result from differences between the human and mouse NOS2 genes, which may program different degrees of nitric oxide responses to inflammatory signals in humans than in mice. Nitrites 74-81 nitric oxide synthase 2, inducible Mus musculus 146-150 16632127-9 2006 A line of evidence including inhibitor studies, EPR spectroscopy, and nitrite/nitrate detection identifies catalase as a possible oxidant for the conversion of hydroxyurea to NO. Nitrites 70-77 catalase Rattus norvegicus 107-115 16644698-5 2006 IL-1beta alone induced a strong inhibition of insulin secretion and glucose oxidation rate and a marked increase in medium nitrite accumulation as an indicator of nitric oxide generation. Nitrites 123-130 interleukin 1 beta Rattus norvegicus 0-8 16622064-4 2006 In a cycA-cycY double mutant, nitrite reduction was largely inhibited. Nitrites 30-37 cyclin Y Homo sapiens 10-14 16502104-6 2006 The P35 elicited increased nitrite production from mononuclear splenocytes from M. a. paratuberculosis-sensitized mice. Nitrites 27-34 interleukin 12a Mus musculus 4-7 16609365-0 2006 A -786T>C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholine. Nitrites 86-93 nitric oxide synthase 3 Homo sapiens 33-66 16543501-4 2006 Relative to data in control rats, arteries from Adv-CYP4A2-transduced rats produced more 20-HETE (129+/-10 versus 97+/-7 pmol/mg protein, P<0.01) and less nitric oxide (NO; 4.2+/-1.6 versus 8.4+/-1 nmol nitrite+nitrate/mg; P<0.05). Nitrites 206-213 cytochrome P450, family 4, subfamily a, polypeptide 2 Rattus norvegicus 52-58 16680018-12 2006 The increase in plasma concentration of nitrate and nitrite was inhibited by BBS-2. Nitrites 52-59 Bardet-Biedl syndrome 2 protein Ovis aries 77-82 16496123-10 2006 Both the reduction in plasma nitrate and nitrite and the elevation in aortic superoxide associated with STZ diabetes were normalised with VEGF treatment. Nitrites 41-48 vascular endothelial growth factor A Rattus norvegicus 138-142 16336215-0 2006 Mechanism of nitrite oxidation by eosinophil peroxidase: implications for oxidant production and nitration by eosinophils. Nitrites 13-20 eosinophil peroxidase Homo sapiens 34-55 16670642-11 2006 In contrast, plasma levels of nitrite/nitrate, IL-1ra (as marker of cytokine response), remained markedly increased at 5 h after endotoxin infusion as compared with baseline values. Nitrites 30-37 interleukin-1 receptor antagonist protein Sus scrofa 47-53 16336215-3 2006 Nitrite is also a substrate for eosinophil peroxidase. Nitrites 0-7 eosinophil peroxidase Homo sapiens 32-53 16336215-8 2006 These results demonstrate that nitrite is readily oxidized by compound I, which contains Fe(V) at the active site. Nitrites 31-38 FEV transcription factor, ETS family member Homo sapiens 89-94 16336215-12 2006 This result is explained by our finding that nitrite reacts 10-fold faster with compound II of eosinophil peroxidase than with the analogous redox intermediate of myeloperoxidase. Nitrites 45-52 eosinophil peroxidase Homo sapiens 95-116 16336215-12 2006 This result is explained by our finding that nitrite reacts 10-fold faster with compound II of eosinophil peroxidase than with the analogous redox intermediate of myeloperoxidase. Nitrites 45-52 myeloperoxidase Homo sapiens 163-178 16336215-14 2006 We propose that at sites of eosinophilic inflammation, low concentrations of nitrite will retard oxidant production by eosinophil peroxidase, whereas at higher concentrations nitrogen dioxide will be a major oxidant formed by these cells. Nitrites 77-84 eosinophil peroxidase Homo sapiens 119-140 16354662-5 2006 The one-electron reactions led to superoxide formation as detected by cytochrome c reduction and, interestingly, reductive N-denitration of tetryl or 2,4-dinitrophenyl-N-methylnitramine, resulting in the release of nitrite. Nitrites 215-222 cytochrome c, somatic Homo sapiens 70-82 16442076-1 2006 In this work, we demonstrate that endothelial nitric oxide synthase is capable of anoxic reduction of nitrite anions to nitric oxide at physiological pH by absorption and EPR spectroscopy and electrochemical measurements. Nitrites 102-109 nitric oxide synthase 3 Homo sapiens 34-67 16430850-3 2006 Moreover, the entrapped Mb realized direct electron transfer with the electrode and displayed an elegant catalytic activity toward the reduction of hydrogen peroxide, nitrite, and trichloroacetic acid, by which the mediator-free biosensors could be fabricated. Nitrites 167-174 myoglobin Homo sapiens 24-26 16545248-6 2006 The concentration of MPO was correlated with the concentrations of 8-isoprostane and nitrate, which were normalized to the nitrite concentration. Nitrites 123-130 myeloperoxidase Homo sapiens 21-24 16544952-9 2006 In the presence of 5 muM nitrite, the concentration in human skin cells, the product yields by sunlight were 5-10-fold greater than those in the absence of nitrite. Nitrites 25-32 latexin Homo sapiens 21-24 16601319-3 2006 Pretreatment with ISO (1-300 microM) resulted in dose-dependent inhibition of accumulation of NOS-2-derived nitrite in culture medium (IC(50) = 9,3 microM) as well as inhibition of NOS-2 protein induction in cultured J774.2 cells; ISO given 10 hours after LPS did not influence activity of NOS-2. Nitrites 108-115 nitric oxide synthase 2, inducible Mus musculus 94-99 16443213-4 2006 NCX 2057 also decreased the levels of LPS/IFNgamma-induced nitrite accumulation (IC(50)=4.3+/-0.7 microM) in RAW 264.7 cells. Nitrites 59-66 T cell leukemia, homeobox 2 Mus musculus 0-3 16443213-4 2006 NCX 2057 also decreased the levels of LPS/IFNgamma-induced nitrite accumulation (IC(50)=4.3+/-0.7 microM) in RAW 264.7 cells. Nitrites 59-66 toll-like receptor 4 Mus musculus 38-41 16443213-4 2006 NCX 2057 also decreased the levels of LPS/IFNgamma-induced nitrite accumulation (IC(50)=4.3+/-0.7 microM) in RAW 264.7 cells. Nitrites 59-66 interferon gamma Mus musculus 42-50 16375865-3 2006 Isolated PGHS-2 in absence of its substrate arachidonate was not only tyrosine-nitrated with peroxynitrite, but also with nitrite/hydrogen peroxide in complete absence of myeloperoxidase. Nitrites 99-106 prostaglandin-endoperoxide synthase 2 Homo sapiens 9-15 16375865-4 2006 Our data favor an autocatalytic activation of nitrite by PGHS-2 with a subsequent nitration of the essential tyrosine residue in the cyclooxygenase domain. Nitrites 46-53 prostaglandin-endoperoxide synthase 2 Homo sapiens 57-63 16375865-5 2006 Under inflammatory conditions, nitrite formed via NO-synthase-2 may therefore act as an endogenous regulator for PGHS-2 in stimulated macrophages. Nitrites 31-38 prostaglandin-endoperoxide synthase 2 Homo sapiens 113-119 16375865-6 2006 Nitration of PGHS-2 by the autocatalytic activation of nitrite further depends on the intracellular concentration of arachidonate since arachidonate reacted competitively with nitrite and could prevent PGHS-2 from nitration when excessively present. Nitrites 55-62 prostaglandin-endoperoxide synthase 2 Homo sapiens 13-19 16375865-6 2006 Nitration of PGHS-2 by the autocatalytic activation of nitrite further depends on the intracellular concentration of arachidonate since arachidonate reacted competitively with nitrite and could prevent PGHS-2 from nitration when excessively present. Nitrites 55-62 prostaglandin-endoperoxide synthase 2 Homo sapiens 202-208 16375865-6 2006 Nitration of PGHS-2 by the autocatalytic activation of nitrite further depends on the intracellular concentration of arachidonate since arachidonate reacted competitively with nitrite and could prevent PGHS-2 from nitration when excessively present. Nitrites 176-183 prostaglandin-endoperoxide synthase 2 Homo sapiens 13-19 16298151-8 2006 Further, SAP treatment of infected AMs induced significant (P<0.05) elaboration of nitrite (72.1+/-8.3 nM/ml), compared to the controls, and these AMs showed augmented expression of inducible NO synthase. Nitrites 86-93 amyloid P component, serum Mus musculus 9-12 16417494-6 2006 Global repression by the nitrate- and nitrite-responsive two-component system, NarQ-NarP, was shown for the first time. Nitrites 38-45 DNA-binding transcriptional dual regulator NarP Escherichia coli str. K-12 substr. MG1655 84-88 16443167-4 2006 In the presence of chloride, bromide, and nitrite, the myeloperoxidase-hydrogen peroxide system caused an oxidation, bromination, and nitrosylation/nitration of eight amino acid residues of albumin as detected by fragment analysis of tryptic digests with matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. Nitrites 42-49 myeloperoxidase Homo sapiens 55-70 16223598-4 2006 The activity of mtNOS and nitrite levels significantly increased after sepsis in iNOS+/+ mice. Nitrites 26-33 nitric oxide synthase 2, inducible Mus musculus 81-85 16288975-4 2006 The selective iNOS inhibitor 1,3-PBIT (10 mg/kg, ip; 1h after endotoxin) prevented endotoxin-induced decrease in MAP, renal CYP 4A1/A3 protein level and CYP 4A activity and increase in systemic and renal nitrite production. Nitrites 204-211 nitric oxide synthase 2 Rattus norvegicus 14-18 16297853-1 2006 Three unusual substrates-bromide (Br(-)), nitrite (NO(2)(-)), and thiocyanate (SCN(-))-compete for oxidation by eosinophil peroxidase (EPO) in physiologic fluids in the presence of H(2)O(2) to yield, respectively, hypobromous acid (HOBr), nitrogen dioxide (NO(2)()), or hypothiocyanous acid (HOSCN). Nitrites 42-49 eosinophil peroxidase Mus musculus 112-133 16436205-5 2006 Nonetheless astrocytes cultured from G93A-SOD1 (but not wild-type human SOD1-expressing) transgenic mouse pups demonstrated a significant elevation in either the basal or the tumor necrosis alpha (TNFalpha)-stimulated levels of proinflammatory eicosanoids prostaglandin E2 (PGE2) and leukotriene B4 (LTB4); inducible nitric oxide synthase (iNOS) and *NO (indexed by nitrite release into the culture medium); and protein carbonyl products. Nitrites 366-373 superoxide dismutase 1 Homo sapiens 42-46 16436205-5 2006 Nonetheless astrocytes cultured from G93A-SOD1 (but not wild-type human SOD1-expressing) transgenic mouse pups demonstrated a significant elevation in either the basal or the tumor necrosis alpha (TNFalpha)-stimulated levels of proinflammatory eicosanoids prostaglandin E2 (PGE2) and leukotriene B4 (LTB4); inducible nitric oxide synthase (iNOS) and *NO (indexed by nitrite release into the culture medium); and protein carbonyl products. Nitrites 366-373 tumor necrosis factor Mus musculus 197-205 16297853-1 2006 Three unusual substrates-bromide (Br(-)), nitrite (NO(2)(-)), and thiocyanate (SCN(-))-compete for oxidation by eosinophil peroxidase (EPO) in physiologic fluids in the presence of H(2)O(2) to yield, respectively, hypobromous acid (HOBr), nitrogen dioxide (NO(2)()), or hypothiocyanous acid (HOSCN). Nitrites 42-49 eosinophil peroxidase Mus musculus 135-138 16413411-2 2006 Recently, we have shown that plasma nitrite mirrors acute changes in endothelial nitric oxide synthase activity in various mammals, including humans. Nitrites 36-43 nitric oxide synthase 3 Homo sapiens 69-102 16166591-1 2006 In vivo, bromide (Br(-)), nitrite (NO(2)(-)), and thiocyanate (SCN(-)) compete for oxidation by eosinophil peroxidase (EPO) and H(2)O(2), yielding, respectively, HOBr, NO(2)., and HOSCN. Nitrites 26-33 eosinophil peroxidase Homo sapiens 96-117 16166591-1 2006 In vivo, bromide (Br(-)), nitrite (NO(2)(-)), and thiocyanate (SCN(-)) compete for oxidation by eosinophil peroxidase (EPO) and H(2)O(2), yielding, respectively, HOBr, NO(2)., and HOSCN. Nitrites 26-33 eosinophil peroxidase Homo sapiens 119-122 16297873-3 2006 The data presented demonstrate that IL-4 alone can inhibit nitrite release in the presence and absence of IL-1beta and partially reverse the IL-1beta induced PGE2 release. Nitrites 59-66 interleukin 4 Homo sapiens 36-40 16216040-0 2006 Easy oxidation and nitration of human myoglobin by nitrite and hydrogen peroxide. Nitrites 51-58 myoglobin Homo sapiens 38-47 16216040-1 2006 The modification of human myoglobin (HMb) by reaction with nitrite and hydrogen peroxide has been investigated. Nitrites 59-66 myoglobin Homo sapiens 26-35 16297873-4 2006 When provided in combination, IL-4 and dynamic compression could further abrogate the IL-1beta induced nitrite and PGE2 release. Nitrites 103-110 interleukin 4 Homo sapiens 30-34 16297873-4 2006 When provided in combination, IL-4 and dynamic compression could further abrogate the IL-1beta induced nitrite and PGE2 release. Nitrites 103-110 interleukin 1 beta Homo sapiens 86-94 16951741-2 2006 The cytochrome c-catalyzed nitration of tyrosine occurred in proportion to the concentration of hydrogen peroxide, nitrite or cytochrome c. Nitrites 115-122 cytochrome c, somatic Homo sapiens 4-16 16951741-8 2006 At this pH, the UV as well as visible spectrum of cytochrome c was changed by nitrite, even in the presence of hydrogen peroxide, probably via the formation of a heme iron-nitric oxide complex. Nitrites 78-85 cytochrome c, somatic Homo sapiens 50-62 16391109-0 2006 Involvement of NarK1 and NarK2 proteins in transport of nitrate and nitrite in the denitrifying bacterium Pseudomonas aeruginosa PAO1. Nitrites 68-75 nitrite extrusion protein 1 Pseudomonas aeruginosa PAO1 15-20 16391109-0 2006 Involvement of NarK1 and NarK2 proteins in transport of nitrate and nitrite in the denitrifying bacterium Pseudomonas aeruginosa PAO1. Nitrites 68-75 nitrite extrusion protein 2 Pseudomonas aeruginosa PAO1 25-30 16391109-1 2006 Two transmembrane proteins were tentatively classified as NarK1 and NarK2 in the Pseudomonas genome project and hypothesized to play an important physiological role in nitrate/nitrite transport in Pseudomonas aeruginosa. Nitrites 176-183 nitrite extrusion protein 1 Pseudomonas aeruginosa PAO1 58-63 16391109-1 2006 Two transmembrane proteins were tentatively classified as NarK1 and NarK2 in the Pseudomonas genome project and hypothesized to play an important physiological role in nitrate/nitrite transport in Pseudomonas aeruginosa. Nitrites 176-183 nitrite extrusion protein 2 Pseudomonas aeruginosa PAO1 68-73 16739926-8 2006 The level of total nitrites NO2-/NO3- was also higher in smokers (5.65 +/- 0.68 vs. 14.6 +/- 1.43; p < 0.001). Nitrites 19-27 NBL1, DAN family BMP antagonist Homo sapiens 33-36 16912414-4 2006 The current data demonstrate that IL-1beta induced nitrite and PGE2 release and inhibited [3H]-thymidine and 35SO4 incorporation. Nitrites 51-58 interleukin 1 beta Homo sapiens 34-42 16912414-5 2006 Inhibitor experiments indicate that 1400W and NS-398 either partially reversed or abolished IL-1beta induced nitrite and PGE2 release. Nitrites 109-116 interleukin 1 beta Homo sapiens 92-100 16308662-9 2006 Taken together, the inhibition of LPS-induced nitrite production might be due to the suppression of NF-kappaB, p38 MAPK signal pathway and the ROS scavenging effect. Nitrites 46-53 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 100-109 16308662-9 2006 Taken together, the inhibition of LPS-induced nitrite production might be due to the suppression of NF-kappaB, p38 MAPK signal pathway and the ROS scavenging effect. Nitrites 46-53 mitogen-activated protein kinase 14 Mus musculus 111-114 16183707-6 2006 IL-1beta impaired acetylcholine (ACh) and sodium nitroprusside (SNP) vasodilation and increased nitrite and O(2)(.) Nitrites 96-103 interleukin 1 beta Rattus norvegicus 0-8 16800771-10 2006 In vivo mechanistic studies with BRBs indicate that they reduce the growth rate of premalignant esophageal cells, in part, through down-regulation of cyclooxygenase-2 leading to reduced prostaglandin production and of inducible nitric oxide synthase leading to reduced nitrate/nitrite levels in the esophagus. Nitrites 277-284 prostaglandin-endoperoxide synthase 2 Homo sapiens 150-166 16328964-5 2006 This cytokine increased inosine concentration from 30 min to 6 h, with no effect at 24 h. Both TNF-alpha and inosine increased nitrite accumulation and nitric oxide synthase activity. Nitrites 127-134 tumor necrosis factor Homo sapiens 95-104 15857166-4 2006 Treatment with erythropoietin inhibited the expression of iNOS mRNA and nitrite production resulting from proinflammatory stimulation by IFN-gamma and LPS. Nitrites 72-79 interferon gamma Rattus norvegicus 137-146 16360270-5 2006 A highly selective iNOS inhibitor GW274150 (1-30 mg/kg orally, 24h after FCA) suppressed the accumulation of nitrite in the inflamed paw indicating substantial iNOS inhibition. Nitrites 109-116 nitric oxide synthase 2 Rattus norvegicus 19-23 15857166-4 2006 Treatment with erythropoietin inhibited the expression of iNOS mRNA and nitrite production resulting from proinflammatory stimulation by IFN-gamma and LPS. Nitrites 72-79 erythropoietin Rattus norvegicus 15-29 16083314-9 2006 Pretreatment with EPO attenuated the increase in nitrite levels; however, this did not reach statistical significance. Nitrites 49-56 erythropoietin Rattus norvegicus 18-21 17332683-5 2006 CORM-3 significantly attenuated the inflammatory response to LPS and INF-gamma as evidenced by a significant reduction (p < 0.001) in nitrite levels and TNF-alpha production (P < 0.05). Nitrites 137-144 interferon gamma Mus musculus 69-78 16133214-7 2005 However, in vitro grown PII mutants did show a higher sensitivity to nitrite (NO (2) (-) ) compared to the wild-type plants. Nitrites 69-76 nitrogen regulatory P-II-like protein Arabidopsis thaliana 24-27 16183332-5 2005 Furthermore, in vitro studies confirmed that NO*-derived species (peroxynitrite and nitrites) and the neutrophil enzyme myeloperoxidase by themselves increased the activation of NF-kappaB, thereby arguing for an in vivo pathogenetic role of NO*-related products and neutrophil enzymes to human ALI. Nitrites 84-92 nuclear factor kappa B subunit 1 Homo sapiens 178-187 16269753-5 2005 Additional experiments revealed that the level of tceA expression was independent of the concentration of chlorinated ethenes (sum concentrations of TCE and DCEs of 2.2 to 333 microM), the concentration of the electron donor hydrogen (concentrations of 12 nM to 17 microM), and the presence of alternate bacterial electron acceptors (5 mM concentrations of fumarate, sulfate, sulfite, thiosulfate, nitrate, or nitrite) but was highly dependent on incubation temperature. Nitrites 410-417 transcription elongation factor A1 Homo sapiens 50-54 16242127-4 2005 NO donors such as S-nitrosoglutathione (GSNO), S-nitroso-N-acetylpenicillamine, and 3-morpholinosydnonimine significantly increased the nitrite concentration while they inhibited the ALDH2 activity. Nitrites 136-143 aldehyde dehydrogenase 2 family member Rattus norvegicus 183-188 16307975-8 2005 Our results showed that diabetic rats were associated with increased 8-OHdG, IL-6, and ET-1 decreased [nitrate+nitrite]. Nitrites 111-118 endothelin 1 Rattus norvegicus 87-91 16006543-6 2005 Nitrate/nitrite plasma levels of Hct-augmented hamsters increased relative to control and L-NAME treated animals. Nitrites 8-15 hair constriction Mus musculus 33-36 16100121-5 2005 Expression of inducible nitric-oxide synthase and cyclooxygenase-2 were also inhibited by cyclopentenone IsoPs as was nitrite and prostaglandin production (IC50 approximately 360 and 210 nM, respectively). Nitrites 118-125 prostaglandin-endoperoxide synthase 2 Mus musculus 50-66 16234848-6 2005 H/R promoted significant increases in cellular nitrite levels that were significantly abrogated by the specific iNOS inhibitor N6-(1-iminoethyl)-L-lysine, di hy drochloride. Nitrites 47-54 nitric oxide synthase 2 Homo sapiens 112-116 16215387-11 2005 In addition, nitrite release from cultured alveolar macrophages was suppressed by IL-10 inhalation (-96%). Nitrites 13-20 interleukin 10 Rattus norvegicus 82-87 16189417-6 2005 Furthermore, STAT-6 mice receiving DSS had dramatically higher levels of serum nitrite/nitrate than all other groups. Nitrites 79-86 signal transducer and activator of transcription 6 Mus musculus 13-19 15902277-8 2005 A single injection of 25 microg of pE9iNOS DNA in a lipid vector into the centre of a murine sarcoma (RIF1) induced iNOS protein expression by four-fold and increased nitrite concentration eight-fold. Nitrites 167-174 replication timing regulatory factor 1 Mus musculus 102-106 15902277-8 2005 A single injection of 25 microg of pE9iNOS DNA in a lipid vector into the centre of a murine sarcoma (RIF1) induced iNOS protein expression by four-fold and increased nitrite concentration eight-fold. Nitrites 167-174 nitric oxide synthase 2, inducible Mus musculus 38-42 16148608-8 2005 RESULTS: Incubation of cultures with interleukin-1beta for 24 h caused a significant increase in nitrite generation. Nitrites 97-104 interleukin 1 beta Rattus norvegicus 37-54 16199562-2 2005 Transcription initiation from the Escherichia coli napF operon control region is activated by the Fnr protein in response to anaerobiosis and by the NarQ-NarP two-component regulatory system in response to nitrate or nitrite. Nitrites 217-224 napF Haemophilus influenzae Rd KW20 51-55 16199562-2 2005 Transcription initiation from the Escherichia coli napF operon control region is activated by the Fnr protein in response to anaerobiosis and by the NarQ-NarP two-component regulatory system in response to nitrate or nitrite. Nitrites 217-224 response regulator Haemophilus influenzae Rd KW20 154-158 16148608-9 2005 Interleukin-1beta-induced nitrite production by vascular smooth muscle cells was significantly suppressed by GGA in a dose-dependent manner. Nitrites 26-33 interleukin 1 beta Rattus norvegicus 0-17 16148608-10 2005 GGA-suppressed nitrite production was accompanied by decreased iNOS mRNA and protein accumulations. Nitrites 15-22 nitric oxide synthase 2 Rattus norvegicus 63-67 16039116-5 2005 Combined with previously reported lower nitrite levels with 1,25(OH)(2)D(3), this increased p53 expression may favor DNA repair over apoptosis. Nitrites 40-47 tumor protein p53 Homo sapiens 92-95 15886273-10 2005 The protective effects of kallikrein were accompanied by increased urinary nitrate/nitrite and cGMP levels, and suppression of superoxide formation. Nitrites 83-90 kallikrein related peptidase 4 Homo sapiens 26-36 16408059-4 2005 We further find that nitrite readily affects cyclic GMP production, cytochrome P450 activities, and heat shock protein 70 and heme oxygenase-1 expression in a variety of tissues. Nitrites 21-28 heme oxygenase 1 Homo sapiens 126-142 16056137-4 2005 Unexpectedly, attenuation of nitrite production by pretreatment with the nitric oxide synthase inhibitor N-Omega-nitro-L-arginine methyl ester greatly enhanced lipopolysaccharide-stimulated secreted phospholipase A2 release from astrocytes; postreatment with N-Omega-nitro-L-arginine methyl ester did not potentiate secreted phospholipase A2 release, and addition of an nitric oxide donor attenuated the secreted phospholipase A2 release. Nitrites 29-36 phospholipase A2 group IB Homo sapiens 199-215 16133968-10 2005 The downregulation of nitrate/nitrite by these inhibitors suggests that TNF-alpha modulates iNOS expression. Nitrites 30-37 tumor necrosis factor Rattus norvegicus 72-81 16133968-10 2005 The downregulation of nitrate/nitrite by these inhibitors suggests that TNF-alpha modulates iNOS expression. Nitrites 30-37 nitric oxide synthase 2 Rattus norvegicus 92-96 16140881-5 2005 The decline in nitrite levels was accompanied by 37 and 67% reductions in iNOS and eNOS expressions, respectively. Nitrites 15-22 nitric oxide synthase 2 Rattus norvegicus 74-78 16056137-4 2005 Unexpectedly, attenuation of nitrite production by pretreatment with the nitric oxide synthase inhibitor N-Omega-nitro-L-arginine methyl ester greatly enhanced lipopolysaccharide-stimulated secreted phospholipase A2 release from astrocytes; postreatment with N-Omega-nitro-L-arginine methyl ester did not potentiate secreted phospholipase A2 release, and addition of an nitric oxide donor attenuated the secreted phospholipase A2 release. Nitrites 29-36 phospholipase A2 group IB Homo sapiens 325-341 16056137-4 2005 Unexpectedly, attenuation of nitrite production by pretreatment with the nitric oxide synthase inhibitor N-Omega-nitro-L-arginine methyl ester greatly enhanced lipopolysaccharide-stimulated secreted phospholipase A2 release from astrocytes; postreatment with N-Omega-nitro-L-arginine methyl ester did not potentiate secreted phospholipase A2 release, and addition of an nitric oxide donor attenuated the secreted phospholipase A2 release. Nitrites 29-36 phospholipase A2 group IB Homo sapiens 325-341 16109514-0 2005 Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia-reperfusion injury. Nitrites 0-7 xanthine dehydrogenase Rattus norvegicus 32-55 15950430-4 2005 Low concentrations of TNFalpha caused luteolysis, which resulted in a decreased level of P4, and increased levels of PGF2alpha, LTC4 and nitrite/nitrate (stable metabolites of nitric oxide-NO) in the blood. Nitrites 137-144 tumor necrosis factor Bos taurus 22-30 16109514-1 2005 BACKGROUND: It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2- -derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS)-dependent NO production is impaired. Nitrites 135-142 xanthine dehydrogenase Rattus norvegicus 37-60 16109514-1 2005 BACKGROUND: It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2- -derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS)-dependent NO production is impaired. Nitrites 135-142 xanthine dehydrogenase Rattus norvegicus 62-65 16007000-1 2005 OBJECTIVES: Controversy exists regarding the effects of polymorphisms in the endothelial nitric oxide synthase (eNOS) gene on nitrites/nitrates (NOx) plasma concentrations. Nitrites 126-134 nitric oxide synthase 3 Homo sapiens 77-110 16033420-3 2005 Although Abeta 25-35 by itself had little effect on iNOS mRNA, protein, and nitrite production, it enhanced TNF-alpha-induced iNOS expression and nitrite generation in OLGs. Nitrites 146-153 tumor necrosis factor Homo sapiens 108-117 16033420-5 2005 Cell permeable C2-ceramide enhanced TNF-alpha-induced iNOS expression and nitrite generation. Nitrites 74-81 tumor necrosis factor Homo sapiens 36-45 16033420-6 2005 Moreover, the specific nSMase inhibitor, 3-O-methyl-sphingomyelin (3-OMS), inhibited iNOS expression and nitrite production induced by TNF-alpha or by the combination of TNF-alpha and Abeta. Nitrites 105-112 sphingomyelin phosphodiesterase 2 Homo sapiens 23-29 16033420-6 2005 Moreover, the specific nSMase inhibitor, 3-O-methyl-sphingomyelin (3-OMS), inhibited iNOS expression and nitrite production induced by TNF-alpha or by the combination of TNF-alpha and Abeta. Nitrites 105-112 tumor necrosis factor Homo sapiens 135-144 16007000-1 2005 OBJECTIVES: Controversy exists regarding the effects of polymorphisms in the endothelial nitric oxide synthase (eNOS) gene on nitrites/nitrates (NOx) plasma concentrations. Nitrites 126-134 nitric oxide synthase 3 Homo sapiens 112-116 16022734-4 2005 RESULTS: HSPG stimulated up-regulation of tumor necrosis factor-alpha (TNF-alpha), production of inducible nitric oxide synthase (iNOS) mRNA and accumulation of TNF-alpha protein and nitrite (NO2-) in a time- and concentration-dependent manner. Nitrites 183-190 syndecan 2 Mus musculus 9-13 16002724-3 2005 E(NO) and nitrite levels were elevated significantly in naive IL-10(-/-) mice as compared with C57 mice. Nitrites 10-17 interleukin 10 Mus musculus 62-67 15774613-1 2005 Plasma levels of nitrite ions have been used as an index of nitric oxide synthase (NOS) activity in vivo. Nitrites 17-24 nitric oxide synthase 2 Homo sapiens 60-81 15622524-5 2005 The appearance of iNOS expression correlates with increased levels of nitrite + nitrate levels and appearance of mitochondrial damage detected either at morphological and biochemical level. Nitrites 70-77 nitric oxide synthase 2 Rattus norvegicus 18-22 16046449-5 2005 In this study, we modified Cu,Zn-superoxide dismutase by using a combination of myeloperoxidase, hydrogen peroxide, and nitrite. Nitrites 120-127 superoxide dismutase 1 Homo sapiens 27-53 15963975-3 2005 Coadministration of icatibant, a bradykinin B(2)-receptor antagonist (200 microg/kg/day), with enalapril blunted the stimulatory effect of the ACE inhibitor on eNOS mRNA expression, circulating levels of nitrite/nitrate, the relaxant activity of ACh and the release of 6-keto-PGF1alpha in L-NAME-treated rats. Nitrites 204-211 angiotensin I converting enzyme Rattus norvegicus 143-146 15829709-5 2005 Total urinary nitrate and nitrite (NOx) excretion rates in UT-A1/3(-/-) mice were more than double those in wild-type mice. Nitrites 26-33 solute carrier family 14 (urea transporter), member 2 Mus musculus 59-64 15888326-10 2005 The lower increase in nitrite production from iNOS together with a greater contractile prostanoid production in the old rats would be responsible for the increase observed in their contraction to phenylephrine after IL-1 ss treatment. Nitrites 22-29 nitric oxide synthase 2 Rattus norvegicus 46-50 15890551-6 2005 Cytokine-stimulated iNOS expression, measured by nitrite accumulation and in vitro l-citrulline production, was similarly reduced by exposing C6 cells to the NF-kappaB inhibitors. Nitrites 49-56 nitric oxide synthase 2 Rattus norvegicus 20-24 15930438-4 2005 Quercetin at 100 micromol/L significantly prevented the IL-1beta-induced release of nitrite into the culture medium. Nitrites 84-91 interleukin 1 beta Rattus norvegicus 56-64 15826818-2 2005 Addition of mIL-4 to the eosinophil culture increased iNOS activity and nitrite production but did not improve the stimulatory effect of IFN-gamma and LPS. Nitrites 72-79 interleukin 4 Mus musculus 12-17 15897676-0 2005 Unexpected effects of nitric oxide synthase inhibitors on extracellular nitrite levels in the hippocampus in vivo. Nitrites 72-79 nitric oxide synthase 2 Homo sapiens 22-43 15826818-3 2005 In contrast to eosinophils, addition of mIL-4 to macrophage cultures inhibited the iNOS expression and nitrite production induced by IFN-gamma plus LPS. Nitrites 103-110 interleukin 4 Mus musculus 40-45 15826818-7 2005 The production of nitrite by eosinophils stimulated by IFN-gamma plus LPS was inhibited by the presence of IL-10 in the medium. Nitrites 18-25 interleukin 18 Rattus norvegicus 55-64 15826818-3 2005 In contrast to eosinophils, addition of mIL-4 to macrophage cultures inhibited the iNOS expression and nitrite production induced by IFN-gamma plus LPS. Nitrites 103-110 interleukin 18 Rattus norvegicus 133-142 15826818-7 2005 The production of nitrite by eosinophils stimulated by IFN-gamma plus LPS was inhibited by the presence of IL-10 in the medium. Nitrites 18-25 interleukin 10 Rattus norvegicus 107-112 15677761-2 2005 We used a nitrite assay to demonstrate that ADM (10 pM to 100 nM) stimulated NO release from the cells, with a maximal response observed with 1 nM at 30 min. Nitrites 10-17 adrenomedullin Homo sapiens 44-47 15971422-2 2005 Nitrotyrosine is formed by nitration of tyrosine by reactive nitrogen species such as peroxynitrite, the formation of which may be enhanced by xanthine oxidoreductase (XOR), since it can generate nitric oxide from nitrite/nitrate, and superoxide during xanthine metabolism. Nitrites 92-99 xanthine dehydrogenase Rattus norvegicus 143-166 15971422-2 2005 Nitrotyrosine is formed by nitration of tyrosine by reactive nitrogen species such as peroxynitrite, the formation of which may be enhanced by xanthine oxidoreductase (XOR), since it can generate nitric oxide from nitrite/nitrate, and superoxide during xanthine metabolism. Nitrites 92-99 xanthine dehydrogenase Rattus norvegicus 168-171 15778348-9 2005 TNF-alpha and IFN-beta, which are secreted by Stat3-inhibited tumor cells, are able to activate macrophage NO production, whereas neutralizing TNF-alpha in the tumor supernatant from Stat3-blocked tumor cells abrogates nitrite production. Nitrites 219-226 tumor necrosis factor Mus musculus 0-9 15808411-7 2005 Nitrite formed either by autooxidation of NO or by conversion of nitrate to nitrite by xanthine oxidase was converted into the powerful nitric dioxide radical by lactoperoxidase and H(2)O(2) that is derived from the metabolism of xanthine oxidase. Nitrites 0-7 lactoperoxidase Bos taurus 162-177 15808411-7 2005 Nitrite formed either by autooxidation of NO or by conversion of nitrate to nitrite by xanthine oxidase was converted into the powerful nitric dioxide radical by lactoperoxidase and H(2)O(2) that is derived from the metabolism of xanthine oxidase. Nitrites 76-83 lactoperoxidase Bos taurus 162-177 15841216-1 2005 Nitrite represents a circulating and tissue storage form of NO whose bioactivation is mediated by the enzymatic action of xanthine oxidoreductase, nonenzymatic disproportionation, and reduction by deoxyhemoglobin, myoglobin, and tissue heme proteins. Nitrites 0-7 xanthine dehydrogenase Mus musculus 122-145 15834587-7 2005 The recovery of DXR-induced growth inhibition was closely associated with an increase in Bcl-2 in the presence of <10 microM nitrite. Nitrites 128-135 BCL2 apoptosis regulator Homo sapiens 89-94 15834587-8 2005 Vascular endothelial growth factor (VEGF) secretion was also increased in the presence of <10 and <20 microM nitrite, respectively, in DU145 and SKRC or T24 cells. Nitrites 115-122 vascular endothelial growth factor A Homo sapiens 0-34 15834587-8 2005 Vascular endothelial growth factor (VEGF) secretion was also increased in the presence of <10 and <20 microM nitrite, respectively, in DU145 and SKRC or T24 cells. Nitrites 115-122 vascular endothelial growth factor A Homo sapiens 36-40 15946604-10 2005 Ex vivo study revealed that RP-1 (50 microg/ml) treatment to peritoneal macrophages inhibited LPS (5 microg/ml) induced nitrite generation to 37%, IFN-gamma secretion to 5%, IL-6 secretion to 50% and TNF-alpha secretion to 50 % of LPS treated control values. Nitrites 120-127 retinitis pigmentosa 1 (human) Mus musculus 28-32 15892615-3 2005 The driving stage of this process is methemoglobin-catalyzed peroxidase oxidation of nitrite. Nitrites 85-92 hemoglobin subunit gamma 2 Homo sapiens 37-50 15778348-9 2005 TNF-alpha and IFN-beta, which are secreted by Stat3-inhibited tumor cells, are able to activate macrophage NO production, whereas neutralizing TNF-alpha in the tumor supernatant from Stat3-blocked tumor cells abrogates nitrite production. Nitrites 219-226 signal transducer and activator of transcription 3 Mus musculus 46-51 15778348-9 2005 TNF-alpha and IFN-beta, which are secreted by Stat3-inhibited tumor cells, are able to activate macrophage NO production, whereas neutralizing TNF-alpha in the tumor supernatant from Stat3-blocked tumor cells abrogates nitrite production. Nitrites 219-226 tumor necrosis factor Mus musculus 143-152 15778348-9 2005 TNF-alpha and IFN-beta, which are secreted by Stat3-inhibited tumor cells, are able to activate macrophage NO production, whereas neutralizing TNF-alpha in the tumor supernatant from Stat3-blocked tumor cells abrogates nitrite production. Nitrites 219-226 signal transducer and activator of transcription 3 Mus musculus 183-188 15778348-10 2005 Moreover, interrupting Stat3 signaling in tumor cells leads to macrophage-mediated, nitrite-dependent cytostatic activity against nontransduced tumor cells. Nitrites 84-91 signal transducer and activator of transcription 3 Mus musculus 23-28 15778348-9 2005 TNF-alpha and IFN-beta, which are secreted by Stat3-inhibited tumor cells, are able to activate macrophage NO production, whereas neutralizing TNF-alpha in the tumor supernatant from Stat3-blocked tumor cells abrogates nitrite production. Nitrites 219-226 interferon beta 1, fibroblast Mus musculus 14-22 15811508-4 2005 We have previously reported that the reaction of nitrite with deoxy-Hb, which furnishes heme-Fe(II)NO, represents one attractive route for the formation of SNO-Hb. Nitrites 49-56 strawberry notch homolog 1 Homo sapiens 156-159 15811508-8 2005 We further show in bioassay experiments that combinations of nitrite and deoxy-Hb--under conditions that suppress SNO-Hb formation--exhibit no direct vasodilatory activity. Nitrites 61-68 strawberry notch homolog 1 Homo sapiens 114-117 15507538-10 2005 Both GHRP-2 (10(-7) M) and ghrelin (10(-7) M) prevented endotoxin-induced IL-6 and decreased nitrite/nitrate release from peritoneal macrophages in vitro. Nitrites 93-100 ghrelin and obestatin prepropeptide Rattus norvegicus 27-34 15784871-12 2005 Sodium nitrite infusions increased the nitrite and methemoglobin levels (<2.1% of total hemoglobin) in the blood and cerebrospinal fluid without evoking systemic hypotension. Nitrites 7-14 hemoglobin subunit gamma 2 Homo sapiens 51-64 15740057-1 2005 The effect of curing agents (salt, glucose, nitrate, nitrite, and ascorbic acid) on the binding of skeletal peptides (carnosine and anserine) and a sarcoplasmic protein (myoglobin) with key flavor compounds (hexanal, octanal, 2-pentanone, 2-methylbutanal, and 3-methylbutanal) has been studied by solid-phase microextraction (SPME). Nitrites 53-60 myoglobin Homo sapiens 170-179 15740057-6 2005 Finally, sodium chloride, glucose, and nitrite increased the interaction of myoglobin with hexanal, octanal, and methional. Nitrites 39-46 myoglobin Homo sapiens 76-85 15810551-6 2005 Using microelectrodes, NA and nitrite were simultaneously measured in pure recombinant eNOS giving similar enzyme activity. Nitrites 30-37 nitric oxide synthase 3 Homo sapiens 87-91 15725942-4 2005 Cultured human aortic vascular smooth muscle cells (HASMC) were stimulated for 18 hours with 10 ng/mL interleukin-1beta (IL-1beta), resulting in a marked increase of iNOS levels and NO production, as determined by Western blotting and nitrite measurement, respectively. Nitrites 235-242 interleukin 1 beta Homo sapiens 102-119 15725942-4 2005 Cultured human aortic vascular smooth muscle cells (HASMC) were stimulated for 18 hours with 10 ng/mL interleukin-1beta (IL-1beta), resulting in a marked increase of iNOS levels and NO production, as determined by Western blotting and nitrite measurement, respectively. Nitrites 235-242 interleukin 1 beta Homo sapiens 121-129 15561798-6 2005 Furthermore, the apicularen A-induced nitrite production was suppressed by the NF-kappaB inhibitor Bay 11-7082 [(E)-3-(4-methylphenylsulfonyl)-2-propenenitrile] and the JNK inhibitor SP600125 [anthra[1,9-cd]pyrazol-6(2H)-one]. Nitrites 38-45 mitogen-activated protein kinase 8 Mus musculus 169-172 15734263-11 2005 Exposure to lipopolysaccharide (LPS) and IFN-gamma significant increased endogenous nitrite production. Nitrites 84-91 interferon gamma Homo sapiens 41-50 15718929-7 2005 Similarly, L-NMMA given prophylactically, but not therapeutically, blocked TNF-alpha-induced increases in exhaled NO flow rates and plasma nitrite and nitrate concentrations (both P = 0.02). Nitrites 139-146 tumor necrosis factor Canis lupus familiaris 75-84 15788155-3 2005 Murine IFN-gamma-activated peritoneal exudate cells (PEC) produced nitric oxide (NO), measured as nitrite plus nitrate, and superoxide. Nitrites 98-105 interferon gamma Mus musculus 7-16 15374815-7 2005 Nitrite production by HT-29 cells was significantly increased (P < 0.01) in cocultures with MMCs stimulated with IFN-gamma and LPS. Nitrites 0-7 interferon gamma Homo sapiens 116-125 15683787-0 2005 Kinetic spectrofluorimetric determination of trace ascorbic acid based on its inhibition on the oxidation of pyronine Y by nitrite. Nitrites 123-130 PTPN13 like Y-linked Homo sapiens 109-119 15683787-2 2005 The method is based on the inhibition of ascorbic acid on the oxidation of pyronine Y (PRY) by nitrite. Nitrites 95-102 PTPN13 like Y-linked Homo sapiens 75-85 15683787-2 2005 The method is based on the inhibition of ascorbic acid on the oxidation of pyronine Y (PRY) by nitrite. Nitrites 95-102 PTPN13 like Y-linked Homo sapiens 87-90 15742413-8 2005 Plasma ET-1 level in DU patients was higher than that of H pylori-negative and positive controls (3.59+/-0.96 vs 0.89+/-0.54 vs 0.3+/-0.2 pg/mL, P<0.01), while nitrate/nitrite levels among them were also significantly different (8.55+/-0.71 vs 5.27+/-0.68 vs 6.39+/-0.92 mumol/L, P<0.05). Nitrites 171-178 endothelin 1 Homo sapiens 7-11 15374815-7 2005 Nitrite production by HT-29 cells was significantly increased (P < 0.01) in cocultures with MMCs stimulated with IFN-gamma and LPS. Nitrites 0-7 interferon regulatory factor 6 Homo sapiens 130-133 15374815-9 2005 Interestingly, stimulation of HT-29 with conditioned media from MMCs pretreated with steroids before stimulation with LPS and IFN-gamma induced a significantly (P < 0.01) lower nitrite production. Nitrites 180-187 interferon regulatory factor 6 Homo sapiens 118-121 15374815-9 2005 Interestingly, stimulation of HT-29 with conditioned media from MMCs pretreated with steroids before stimulation with LPS and IFN-gamma induced a significantly (P < 0.01) lower nitrite production. Nitrites 180-187 interferon gamma Homo sapiens 126-135 15377279-2 2005 Conversion of GTN into 1,2-GDN (1,2-glycerol dinitrate) and nitrite by mitochondrial ALDH2 (aldehyde dehydrogenase 2) may be an essential pathway of GTN bioactivation in blood vessels. Nitrites 60-67 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 85-90 15655519-8 2005 The inducible nitric oxide synthase (iNOS) inhibitor, 1400 W (10 microM) and Tolb inhibited the production of nitrite induced by LPS, whereas BaCl(2) and PNU-37883A had no effect. Nitrites 110-117 nitric oxide synthase 2 Rattus norvegicus 4-35 15655519-8 2005 The inducible nitric oxide synthase (iNOS) inhibitor, 1400 W (10 microM) and Tolb inhibited the production of nitrite induced by LPS, whereas BaCl(2) and PNU-37883A had no effect. Nitrites 110-117 nitric oxide synthase 2 Rattus norvegicus 37-41 15377279-2 2005 Conversion of GTN into 1,2-GDN (1,2-glycerol dinitrate) and nitrite by mitochondrial ALDH2 (aldehyde dehydrogenase 2) may be an essential pathway of GTN bioactivation in blood vessels. Nitrites 60-67 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 92-116 15693824-4 2005 Nitrate reduction varied between individuals (mean 85.4 +/- 15.9 nmol nitrite min(-1) with 10 ml 1 mm KNO(3) mouth wash) and was found to be concentrated at the rear of the tongue dorsal surface. Nitrites 70-77 CD59 molecule (CD59 blood group) Homo sapiens 78-84 15665833-3 2005 Ganciclovir treatment of organotypic brain slice cultures derived from CD11b-HSVTK mice abolished microglial release of nitrite, proinflammatory cytokines and chemokines. Nitrites 120-127 integrin alpha M Mus musculus 71-76 15667592-8 2005 When control macrophages were activated with lipopolysaccharide+interferon-gamma for 24 hr a significant increase in nitrite content and in prostanoids were observed. Nitrites 117-124 interferon gamma Sus scrofa 64-80 15620895-7 2005 The method was applied to the determination of nitrite in tap water, waste water, and human urine samples. Nitrites 47-54 nuclear RNA export factor 1 Homo sapiens 58-61 15669350-3 2004 In the absence of O2, CL-20 underwent a rapid decomposition with the concurrent formation of nitrite to ultimately produce nitrous oxide, ammonium, formate, glyoxal, and glycolate. Nitrites 93-100 epithelial membrane protein 1 Homo sapiens 22-27 15773227-5 2005 Increased expression (by 104%) and activity (3.3-fold) of iNOS was specifically observed in proximal tubules (PTs) of the cortex, accompanied by higher (2-fold) tissue nitrite levels. Nitrites 168-175 nitric oxide synthase 2 Rattus norvegicus 58-62 15598504-3 2005 In this review we survey, in the context of our own recent studies, the chemical reactivity of nitrite with oxyhemoglobin, deoxyhemoglobin and methemoglobin, and place these reactions in both a physiological and pharmacological/therapeutic context. Nitrites 95-102 hemoglobin subunit gamma 2 Homo sapiens 143-156 15585341-5 2005 The JNK inhibitor SP600125 and the p38 inhibitor SB203580 independently reduced both nitrite accumulation and induction of inflammatory nitric oxide synthase (iNOS). Nitrites 85-92 mitogen-activated protein kinase 8 Homo sapiens 4-7 15585341-5 2005 The JNK inhibitor SP600125 and the p38 inhibitor SB203580 independently reduced both nitrite accumulation and induction of inflammatory nitric oxide synthase (iNOS). Nitrites 85-92 mitogen-activated protein kinase 1 Homo sapiens 35-38 16180452-0 2005 Microbial sulphate reduction during anaerobic digestion: EGSB process performance and potential for nitrite suppression of SRB activity. Nitrites 100-107 chaperonin containing TCP1 subunit 4 Homo sapiens 123-126 15577225-6 2004 Pretreatment with protocatechuic acid isopropyl ester effectively suppressed the LPS/GalN-induced increase in plasma tumor necrosis factor (TNF)-alpha alanine aminotransferase (ALT), nitrite/nitrate levels, and hepatic malondialdehyde levels. Nitrites 183-190 toll-like receptor 4 Mus musculus 81-84 15607619-6 2004 The level of plasma nitrite/nitrate was associated with the change in iNOS expression in SHR. Nitrites 20-27 nitric oxide synthase 2 Rattus norvegicus 70-74 15554929-8 2004 In contrast, PARP-1(-/-) mice exhibited a significant reduction of colon damage and apoptosis, which was associated with increased colonic expression of Bcl-2 and lower levels of plasma nitrate/nitrite when compared to wild-type mice. Nitrites 194-201 poly (ADP-ribose) polymerase family, member 1 Mus musculus 13-19 15498507-1 2004 It has been reported that macrophages produce substantial amounts of nitrite and nitrate after addition of catalase, but the mechanism associated remains unclear. Nitrites 69-76 catalase Mus musculus 107-115 15567873-4 2004 METHODS: We used data from a multicentre, case-control study with maternal information on residential water source, and nitrate/nitrite levels of tap water measured by dipstick. Nitrites 128-135 nuclear RNA export factor 1 Homo sapiens 146-149 16245077-7 2004 EPEC OMP up regulated iNOS, induced nitrite production and NF-kappaB and MAPK were activated in caco-2 cells. Nitrites 36-43 olfactory marker protein Homo sapiens 5-8 15475378-2 2004 NR activity in tomato roots increased significantly after 24 h of anaerobiosis and increased further by 48 h, with a concomitant release of nitrite into the culture medium. Nitrites 140-147 nitrate reductase [NADH] Solanum lycopersicum 0-2 15554716-1 2004 Cytochrome c nitrite reductase is a dimeric decaheme-containing enzyme that catalyzes the reduction of nitrite to ammonium. Nitrites 13-20 cytochrome c, somatic Homo sapiens 0-12 15477010-10 2004 In addition, HOCl-oxidized cyt c (HOCl-cyt c) exhibited a higher affinity for NO and enhancement of nonenzymatic NO synthesis from nitrite reduction. Nitrites 131-138 cytochrome c, somatic Homo sapiens 27-32 15477010-10 2004 In addition, HOCl-oxidized cyt c (HOCl-cyt c) exhibited a higher affinity for NO and enhancement of nonenzymatic NO synthesis from nitrite reduction. Nitrites 131-138 cytochrome c, somatic Homo sapiens 39-44 15477010-11 2004 Furthermore, HOCl-mediated cyt c oxidation also resulted in a significant elevation of cyt c nitration derived from either NO trapping of the cyt c-derived tyrosyl radical or cyt c-catalyzed one-electron oxidation of nitrite. Nitrites 217-224 cytochrome c, somatic Homo sapiens 27-32 15477010-11 2004 Furthermore, HOCl-mediated cyt c oxidation also resulted in a significant elevation of cyt c nitration derived from either NO trapping of the cyt c-derived tyrosyl radical or cyt c-catalyzed one-electron oxidation of nitrite. Nitrites 217-224 cytochrome c, somatic Homo sapiens 87-92 15477010-11 2004 Furthermore, HOCl-mediated cyt c oxidation also resulted in a significant elevation of cyt c nitration derived from either NO trapping of the cyt c-derived tyrosyl radical or cyt c-catalyzed one-electron oxidation of nitrite. Nitrites 217-224 cytochrome c, somatic Homo sapiens 87-92 15477010-11 2004 Furthermore, HOCl-mediated cyt c oxidation also resulted in a significant elevation of cyt c nitration derived from either NO trapping of the cyt c-derived tyrosyl radical or cyt c-catalyzed one-electron oxidation of nitrite. Nitrites 217-224 cytochrome c, somatic Homo sapiens 87-92 15450943-11 2004 Epicatechin significantly reduced IL-1beta-induced nitrite production, iNOS protein and mRNA expressions, and it also inhibited IL-1beta-induced IkappaBalpha protein degradation, NF-kappaB activation, and iNOS promoter activity. Nitrites 51-58 interleukin 1 beta Rattus norvegicus 34-42 15308624-6 2004 In contrast, antisense knockdown of DNA methyltransferase-3b expression and activity increased iNOS promoter activity and nitrite production. Nitrites 122-129 DNA methyltransferase 3B Mus musculus 36-60 15345513-9 2004 Nitrite levels and the ratio of reduced to oxidized glutathione were selectively increased in ischemic muscles by NCX 4016. Nitrites 0-7 T cell leukemia, homeobox 2 Mus musculus 114-117 15454240-2 2004 The inhibition of the newly discovered cytosolic carbonic anhydrase (CA, EC 4.2.1.1) isozyme XIII of murine origin (mCA XIII) has been investigated with a series of anions, such as the physiological ones (bicarbonate, chloride), or the metal complexing anions (cyanate, cyanide, azide, hydrogen sulfide, etc), nitrate, nitrite, sulfate, sulfamate, sulfamide as well as with phenylboronic and phenylarsonic acids. Nitrites 319-326 carbonic anhydrase 13 Mus musculus 116-124 15627874-8 2004 However, there was a significantly positive correlation between BALF IL-8 and nitrite levels in patients with CF (r = 0.5) and also in control patients (r = 0.6). Nitrites 78-85 C-X-C motif chemokine ligand 8 Homo sapiens 69-73 15521966-7 2004 The serum concentrations of high density lipoprotein (HDL) cholesterol and nitrite/nitrate were significantly lower in the E4 group than in the E2 group (P < 0.05). Nitrites 75-82 ubiquitination factor E4A Homo sapiens 123-125 15505162-12 2004 CONCLUSIONS: CSF nitrite and nitrate levels were increased in mildly disabled patients with MS and found to correlate with the volume of Gd-enhanced lesions on MRI. Nitrites 17-24 colony stimulating factor 2 Homo sapiens 13-16 15636171-3 2004 We observed a concentration-dependent suppression of nitrite formation by about 80%, which was due to an inhibition of iNOS expression. Nitrites 53-60 nitric oxide synthase 2 Rattus norvegicus 119-123 15301945-5 2004 The immobilized Mb displayed good electrocatalytic responses to the reduction of both hydrogen peroxide (H(2)O(2)) and nitrite (NO(2)(-)), which were used to develop novel sensors for H(2)O(2) and NO(2)(-). Nitrites 119-126 myoglobin Homo sapiens 16-18 15258160-7 2004 IRP-1 nitration was strongly reduced when IFN-gamma/LPS/PMA-stimulated cells were incubated with myeloperoxidase inhibitors, which points to the contribution of the nitrite/H2O2/peroxidase pathway to IRP-1 nitration in vivo. Nitrites 165-172 aconitase 1 Mus musculus 0-5 15258160-7 2004 IRP-1 nitration was strongly reduced when IFN-gamma/LPS/PMA-stimulated cells were incubated with myeloperoxidase inhibitors, which points to the contribution of the nitrite/H2O2/peroxidase pathway to IRP-1 nitration in vivo. Nitrites 165-172 interferon gamma Mus musculus 42-51 15258160-7 2004 IRP-1 nitration was strongly reduced when IFN-gamma/LPS/PMA-stimulated cells were incubated with myeloperoxidase inhibitors, which points to the contribution of the nitrite/H2O2/peroxidase pathway to IRP-1 nitration in vivo. Nitrites 165-172 myeloperoxidase Mus musculus 97-112 15490108-6 2004 The expression and activity of eNOS were measured using quantitative PCR and nitrite measurements respectively. Nitrites 77-84 nitric oxide synthase 3 Homo sapiens 31-35 15187170-5 2004 Both 2AG and CP55,940 significantly increased the production of nitrite from mast cells, which was abrogated by L-NAME and N-(3-(aminomethyl)benzyl)acetamidine (1400W), a selective inducible NOS (iNOS) inhibitor. Nitrites 64-71 nitric oxide synthase, inducible Cavia porcellus 181-194 15187170-5 2004 Both 2AG and CP55,940 significantly increased the production of nitrite from mast cells, which was abrogated by L-NAME and N-(3-(aminomethyl)benzyl)acetamidine (1400W), a selective inducible NOS (iNOS) inhibitor. Nitrites 64-71 nitric oxide synthase, inducible Cavia porcellus 196-200 15187170-6 2004 Nitrite production consistently paralleled a CP55,940-induced increase in the expression of iNOS protein in mast cells. Nitrites 0-7 nitric oxide synthase, inducible Cavia porcellus 92-96 15373757-7 2004 RESULTS: Oxytocin increased nitrite release by fetal membranes. Nitrites 28-35 oxytocin/neurophysin I prepropeptide Homo sapiens 9-17 15493876-1 2004 Oxidative modification of low-density lipoprotein (LDL) is a pivotal process in early atherogenesis and can be brought about by myeloperoxidase (MPO), which is capable of reacting with nitrite, a NO metabolite. Nitrites 185-192 myeloperoxidase Homo sapiens 128-143 15493876-1 2004 Oxidative modification of low-density lipoprotein (LDL) is a pivotal process in early atherogenesis and can be brought about by myeloperoxidase (MPO), which is capable of reacting with nitrite, a NO metabolite. Nitrites 185-192 myeloperoxidase Homo sapiens 145-148 15493876-2 2004 We studied MPO-mediated formation of conjugated dienes in isolated human LDL in dependence on the concentrations of nitrite and chloride. Nitrites 116-123 myeloperoxidase Homo sapiens 11-14 15493876-6 2004 We propose a prominent role of lipid peroxidation for the proatherogenic action of the MPO/nitrite system, whereas peroxynitrite may be competent for protein tyrosine nitration of LDL. Nitrites 91-98 myeloperoxidase Homo sapiens 87-90 15493876-7 2004 Monomeric and oligomeric flavan-3-ols present in cocoa products effectively counteracted, at micromolar concentrations, the MPO/nitrite-mediated lipid peroxidation of LDL. Nitrites 128-135 myeloperoxidase Homo sapiens 124-127 15461866-9 2004 Oral administration of HCT-1026 (15 mg/kg) or NCX-2216 (100 mg/kg) to naive rats was followed by significant and long lasting increases in cortical nitrite levels. Nitrites 148-155 T cell leukemia homeobox 2 Homo sapiens 46-49 15371131-6 2004 As well as induction of iNOS by LPS, "constitutive" iNOS was present in some cultures, producing nitrite in amounts that were also subsequently reduced after cell treatment with 1400 W. CONCLUSION: Rat mesenteric LSMC produce nitrite and express iNOS in response to bacterial LPS. Nitrites 97-104 nitric oxide synthase 2 Rattus norvegicus 52-56 15371131-3 2004 Treatment of LSMC for 24 h with LPS (1-100 microg/mL) activated iNOS protein induction, associated with (1) assay of increased nitrite concentrations in the medium representing cellular nitric oxide synthesis, and (2) demonstration of iNOS in cell extracts by Western blotting. Nitrites 127-134 nitric oxide synthase 2 Rattus norvegicus 64-68 15371131-6 2004 As well as induction of iNOS by LPS, "constitutive" iNOS was present in some cultures, producing nitrite in amounts that were also subsequently reduced after cell treatment with 1400 W. CONCLUSION: Rat mesenteric LSMC produce nitrite and express iNOS in response to bacterial LPS. Nitrites 97-104 nitric oxide synthase 2 Rattus norvegicus 52-56 15371131-5 2004 1400 W (1 microM), a selective iNOS inhibitor, prevented LPS-induced nitrite formation but not iNOS expression. Nitrites 69-76 nitric oxide synthase 2 Rattus norvegicus 31-35 15371131-6 2004 As well as induction of iNOS by LPS, "constitutive" iNOS was present in some cultures, producing nitrite in amounts that were also subsequently reduced after cell treatment with 1400 W. CONCLUSION: Rat mesenteric LSMC produce nitrite and express iNOS in response to bacterial LPS. Nitrites 226-233 nitric oxide synthase 2 Rattus norvegicus 52-56 15371131-6 2004 As well as induction of iNOS by LPS, "constitutive" iNOS was present in some cultures, producing nitrite in amounts that were also subsequently reduced after cell treatment with 1400 W. CONCLUSION: Rat mesenteric LSMC produce nitrite and express iNOS in response to bacterial LPS. Nitrites 226-233 nitric oxide synthase 2 Rattus norvegicus 52-56 15353992-13 2004 Alone, interferon gamma (IFNgamma)--but not IL-1beta or TNFalpha--generated nitrite in vitro. Nitrites 76-83 interferon gamma Mus musculus 25-33 15353992-14 2004 A cytokine cocktail of IL-1beta, TNFalpha, and IFNgamma synergistically enhanced nitrite production. Nitrites 81-88 interleukin 1 beta Mus musculus 23-31 15294346-4 2004 IL-1beta mRNA transcription was reduced by 35% following nitrite inhalant exposure, consistent with inhibition of activation-induced phosphorylation of macrophage mitogen-activated protein kinase p38. Nitrites 57-64 interleukin 1 beta Homo sapiens 0-8 15353992-14 2004 A cytokine cocktail of IL-1beta, TNFalpha, and IFNgamma synergistically enhanced nitrite production. Nitrites 81-88 tumor necrosis factor Mus musculus 33-41 15294346-4 2004 IL-1beta mRNA transcription was reduced by 35% following nitrite inhalant exposure, consistent with inhibition of activation-induced phosphorylation of macrophage mitogen-activated protein kinase p38. Nitrites 57-64 mitogen-activated protein kinase 14 Homo sapiens 196-199 15353992-14 2004 A cytokine cocktail of IL-1beta, TNFalpha, and IFNgamma synergistically enhanced nitrite production. Nitrites 81-88 interferon gamma Mus musculus 47-55 15353992-19 2004 The pro-inflammatory cytokines, IL-1beta, TNFalpha, and IFNgamma, synergistically induce nitrite production, which was abrogated by treatment with the nitric oxide synthase inhibitor, AG. Nitrites 89-96 interleukin 1 beta Mus musculus 32-40 15353992-19 2004 The pro-inflammatory cytokines, IL-1beta, TNFalpha, and IFNgamma, synergistically induce nitrite production, which was abrogated by treatment with the nitric oxide synthase inhibitor, AG. Nitrites 89-96 tumor necrosis factor Mus musculus 42-50 15294346-7 2004 Nitrite inhalant exposure blocked activation-induced increases in caspase-1 activity, consistent with a 50% reduction in 17 kDa IL-1beta shown in Western blots. Nitrites 0-7 caspase 1 Homo sapiens 66-75 15294346-7 2004 Nitrite inhalant exposure blocked activation-induced increases in caspase-1 activity, consistent with a 50% reduction in 17 kDa IL-1beta shown in Western blots. Nitrites 0-7 interleukin 1 beta Homo sapiens 128-136 15353992-19 2004 The pro-inflammatory cytokines, IL-1beta, TNFalpha, and IFNgamma, synergistically induce nitrite production, which was abrogated by treatment with the nitric oxide synthase inhibitor, AG. Nitrites 89-96 interferon gamma Mus musculus 56-64 15294346-8 2004 Thus, exposure to nitrite inhalants reduced macrophage production of IL-1beta by reducing transcription, as well as post-translational processing mediated by caspase-1. Nitrites 18-25 interleukin 1 beta Homo sapiens 69-77 15353992-19 2004 The pro-inflammatory cytokines, IL-1beta, TNFalpha, and IFNgamma, synergistically induce nitrite production, which was abrogated by treatment with the nitric oxide synthase inhibitor, AG. Nitrites 89-96 nitric oxide synthase 1, neuronal Mus musculus 151-172 15294346-8 2004 Thus, exposure to nitrite inhalants reduced macrophage production of IL-1beta by reducing transcription, as well as post-translational processing mediated by caspase-1. Nitrites 18-25 caspase 1 Homo sapiens 158-167 15212902-9 2004 Products of CL-20 oxic degradation included three high molecular weight compounds and anions (nitrite and formate). Nitrites 94-101 epithelial membrane protein 1 Homo sapiens 12-17 15304319-4 2004 In the presence of nitrite and hydrogen peroxide, AtGLB1 was the most efficient at mediating tyrosine nitration of its own and other proteins via the formation of reactive nitrogen species as a result of nitrite oxidation. Nitrites 19-26 nitrogen regulatory P-II-like protein Arabidopsis thaliana 50-56 15304319-4 2004 In the presence of nitrite and hydrogen peroxide, AtGLB1 was the most efficient at mediating tyrosine nitration of its own and other proteins via the formation of reactive nitrogen species as a result of nitrite oxidation. Nitrites 204-211 nitrogen regulatory P-II-like protein Arabidopsis thaliana 50-56 15304319-5 2004 AtGLB1 mRNA significantly accumulated in Arabidopsis seedlings exposed to nitrite, supporting the physiological relevance of its function to nitrite and nitrite-derived reactive nitrogen species. Nitrites 74-81 nitrogen regulatory P-II-like protein Arabidopsis thaliana 0-6 15304319-5 2004 AtGLB1 mRNA significantly accumulated in Arabidopsis seedlings exposed to nitrite, supporting the physiological relevance of its function to nitrite and nitrite-derived reactive nitrogen species. Nitrites 141-148 nitrogen regulatory P-II-like protein Arabidopsis thaliana 0-6 15304319-5 2004 AtGLB1 mRNA significantly accumulated in Arabidopsis seedlings exposed to nitrite, supporting the physiological relevance of its function to nitrite and nitrite-derived reactive nitrogen species. Nitrites 141-148 nitrogen regulatory P-II-like protein Arabidopsis thaliana 0-6 15304320-7 2004 In chondrocytes overexpressing functional PPARgamma protein, 15d-PGJ(2) pre-treatment inhibited inducible NO synthase and COX-2 mRNA expression, nitrite and PGE(2) production, p65 translocation and NF-kappaB activation. Nitrites 145-152 peroxisome proliferator-activated receptor gamma Rattus norvegicus 42-51 15309569-9 2004 In addition, an inhibitor of HO-1 activity, chromium III mesoporhyrin (CrMP), attenuated the inhibitory activity of TauBr but not that of TauCl, as measured by nitrite accumulation. Nitrites 160-167 heme oxygenase 1 Mus musculus 29-33 15673165-5 2004 Nitrite production induced by inflammatory IL-1beta on cultured chondrocytes was inhibited by the N-benzo[d]isothiazol-3-yl-amidines tested, in particular by N-benzo[d]isothiazol-3-yl-benzamidine, which was the most active. Nitrites 0-7 interleukin 1 beta Homo sapiens 43-51 15598426-5 2004 Experiments employing immunomagnetic depletion of Mac-1+ cells from ascites indicated that macrophages were a major cellular source of the nitrite production. Nitrites 139-146 integrin alpha M Mus musculus 50-55 15166094-6 2004 Surprisingly, iNOS expression was not increased at 72 hours; instead, upregulation of neuronal NO synthase (nNOS) was evident at both the mRNA (+266+/-20%, P<0.005) and the protein levels (+195+/-66%, P<0.005), which was accompanied by an increase in myocardial nitrite/nitrate (+20+/-4%, P<0.05). Nitrites 268-275 nitric oxide synthase, brain Oryctolagus cuniculus 108-112 15203186-9 2004 Nitrite--recently found to be a substrate for MPO--showed some competing properties. Nitrites 0-7 myeloperoxidase Homo sapiens 46-49 15115662-6 2004 Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation. Nitrites 75-82 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 18-23 15115662-6 2004 Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation. Nitrites 75-82 interleukin 1 beta Homo sapiens 49-57 15115662-6 2004 Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation. Nitrites 75-82 interferon gamma Homo sapiens 58-66 15115662-6 2004 Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation. Nitrites 206-213 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 18-23 15115662-6 2004 Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation. Nitrites 206-213 interleukin 1 beta Homo sapiens 49-57 15115662-6 2004 Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation. Nitrites 206-213 interferon gamma Homo sapiens 58-66 15297929-3 2004 Results further showed that the populations of both ammonia and nitrite oxidizers were significantly enriched with the increase of the substrate N/COD ratio, while a decreasing trend of heterotrophic population was observed in the aerobic granules. Nitrites 64-71 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 147-150 15179450-10 2004 The finding of increased liver nitrite/nitrate content in NCX-1000-treated animals together with an increase in cGMP levels in their liver homogenates suggests that this nitro-compound behaves as a liver-selective NO donor. Nitrites 31-38 T cell leukemia homeobox 2 Homo sapiens 58-61 15220209-5 2004 The inhibition of p42/44 MAPK and protein kinase C prevented, whereas inhibition of p38 MAPK augmented, AGE-induced nitrite release and iNOS expression. Nitrites 116-123 cyclin-dependent kinase 20 Mus musculus 18-21 15220209-5 2004 The inhibition of p42/44 MAPK and protein kinase C prevented, whereas inhibition of p38 MAPK augmented, AGE-induced nitrite release and iNOS expression. Nitrites 116-123 mitogen-activated protein kinase 14 Mus musculus 84-92 15224139-11 2004 The results suggested that eNOS gene promoter activity was enhanced to 148.2+/-33.7% (P<0.05) of the control after PAECs were incubated with 10 micromol/L histamine for 24 h. The nitrite and nitrate content in culture media measured by colorimetric method after incubation with 10 micromol/L histamine for 24 h indicated that the NO production in PAECs was increased. Nitrites 182-189 nitric oxide synthase 3 Homo sapiens 27-31 15214777-4 2004 Chemiluminescence detection experiments show the ability of catalase to catalyze the formation of nitrite and nitrate from hydroxyurea. Nitrites 98-105 catalase Homo sapiens 60-68 15064952-7 2004 Insulin also induced membrane hyperpolarization and increased intracellular Ca2+, L-[3H]citrulline, cGMP and nitrite formation. Nitrites 109-116 insulin Homo sapiens 0-7 15285793-3 2004 METHODS: Rat cortical microglia were stimulated with bacterial lipopolysaccharide (LPS) to induce NOS2 expression (assessed by nitrite and nitrate accumulation, NO production, and NOS2 mRNA levels) and IL-1beta release (assessed by ELISA). Nitrites 127-134 nitric oxide synthase 2 Rattus norvegicus 98-102 15173317-6 2004 Activation of parent, vector- or p35-transfected cells with cisplatin and IFN-gamma or LPS and IFN-gamma caused equivalent levels of inducible nitric oxide synthase (iNOS) expression and produced equal amounts of nitrite, which ruled out attenuated iNOS activity during P35-mediated protection. Nitrites 213-220 interferon gamma Mus musculus 95-104 15191513-7 2004 In these patients (inducible nitric oxide synthase-positive group), the serum level of gastrin was significantly higher than that of the inducible nitric oxide synthase-negative group (509.5 +/- 141.5 pg/mL vs. 210.0 +/- 227.2 pg/mL; P < 0.01), whereas there were no significant differences in serum levels of pepsinogen, anti-parietal cell antibody, and nitrate and nitrite or in scores of histological gastritis. Nitrites 370-377 gastrin Homo sapiens 87-94 14751861-6 2004 Tiron or SOD significantly increased nitrite released from vessels of aged rats, but this was still significantly less than that in young rats. Nitrites 37-44 superoxide dismutase 1 Rattus norvegicus 9-12 15147953-4 2004 The data presented demonstrate that TGFbeta3 enhanced 35SO4 and [3H]thymidine incorporation and inhibited nitrite release after 48 h of culture when compared to unsupplemented constructs. Nitrites 106-113 transforming growth factor beta 3 Homo sapiens 36-44 15142856-8 2004 IL-6 caused reductions in ACh- and bradykinin-induced vascular relaxation and nitrite production that were more prominent in pregnant than virgin rats. Nitrites 78-85 interleukin 6 Rattus norvegicus 0-4 15457925-9 2004 Leptin treatment significantly increased tissue SH and plasma nitrite levels when compared to the I/R group (p < 0.05). Nitrites 62-69 leptin Rattus norvegicus 0-6 15155666-3 2004 ApoE knockout mice were infected with T. gondii, and at 5 weeks of infection, serum, feces, and liver cholesterol; aortic lesion size, cellularity, and inflammatory cytokines; and levels of serum nitrite and gamma interferon (IFN-gamma) were analyzed. Nitrites 196-203 apolipoprotein E Mus musculus 0-4 15457925-11 2004 These results suggest that leptin could exert a protective effect on I/R induced renal damage by decreasing TNF-alpha levels and increasing nitrite level. Nitrites 140-147 leptin Rattus norvegicus 27-33 15173604-9 2004 In RAW 264.7 murine macrophage cells stimulated with lipopolysaccharide (1 microg/ml), NCX 6550, but not pravastatin, significantly decreased inducible NO synthase and cyclooxygenase-2 protein expression as well as nitrite accumulation. Nitrites 215-222 T cell leukemia, homeobox 2 Mus musculus 87-90 14607816-2 2004 C57BL/6 mice injected intraperitoneally with the specific inducible NO synthase (iNOS) inhibitor 1400W (10 mg/kg every 8 h for 72 h) exhibited decreased alveolar nitrite levels and Na(+)-dependent amiloride-sensitive alveolar fluid clearance as compared with mice injected with vehicle. Nitrites 162-169 nitric oxide synthase 2, inducible Mus musculus 81-85 15370299-5 2004 Pretreatment of BAECs with CLA mix (10 microg/mL) for either 3 or 24 h, followed by incubation with 5 microM bradykinin (BK) for 3 h, however, increased BK-stimulated nitrite release by 2.4 +/- 0.6- and 3.0 +/- 0.4-fold, respectively, more than control cells (BK-stimulation without CLA pretreatment). Nitrites 167-174 kininogen 1 Bos taurus 109-119 15080860-2 2004 Our previous studies suggested a relationship between cerebrospinal fluid (CSF) NO metabolites (nitrates and nitrites, NN(x)) and IGF-1 in patients with progressive encephalopathy, hypsarrhythmia and optic atrophy syndrome. Nitrites 109-117 insulin like growth factor 1 Homo sapiens 130-135 15088102-9 2004 Nitrite and nitrate release from hearts before (2.3 +/- 0.9 nmol/min/g) and after (2.4 +/- 1.9 nmol/min/g) 15 min treatment with erythropoietin (1.0 U/ml) were not different. Nitrites 0-7 erythropoietin Oryctolagus cuniculus 129-143 15155540-2 2004 In 8-week-old mice, myeloperoxidase (MPO) levels are significantly elevated in the early phase at 6 h and reach their maximum at 24 h to decline to basal value at 48 h. Nitrate+nitrite (NO(x)) levels in the paw are maximal after 2 h and slowly decline thereafter in contrast to prostaglandin E(2) levels that peak in the second phase at the 72 h point. Nitrites 177-184 myeloperoxidase Mus musculus 20-35 15155540-2 2004 In 8-week-old mice, myeloperoxidase (MPO) levels are significantly elevated in the early phase at 6 h and reach their maximum at 24 h to decline to basal value at 48 h. Nitrate+nitrite (NO(x)) levels in the paw are maximal after 2 h and slowly decline thereafter in contrast to prostaglandin E(2) levels that peak in the second phase at the 72 h point. Nitrites 177-184 myeloperoxidase Mus musculus 37-40 15370299-5 2004 Pretreatment of BAECs with CLA mix (10 microg/mL) for either 3 or 24 h, followed by incubation with 5 microM bradykinin (BK) for 3 h, however, increased BK-stimulated nitrite release by 2.4 +/- 0.6- and 3.0 +/- 0.4-fold, respectively, more than control cells (BK-stimulation without CLA pretreatment). Nitrites 167-174 kininogen 1 Bos taurus 121-123 15370299-5 2004 Pretreatment of BAECs with CLA mix (10 microg/mL) for either 3 or 24 h, followed by incubation with 5 microM bradykinin (BK) for 3 h, however, increased BK-stimulated nitrite release by 2.4 +/- 0.6- and 3.0 +/- 0.4-fold, respectively, more than control cells (BK-stimulation without CLA pretreatment). Nitrites 167-174 kininogen 1 Bos taurus 153-155 15370299-5 2004 Pretreatment of BAECs with CLA mix (10 microg/mL) for either 3 or 24 h, followed by incubation with 5 microM bradykinin (BK) for 3 h, however, increased BK-stimulated nitrite release by 2.4 +/- 0.6- and 3.0 +/- 0.4-fold, respectively, more than control cells (BK-stimulation without CLA pretreatment). Nitrites 167-174 kininogen 1 Bos taurus 153-155 15081246-2 2004 Upon LPS challenge, we observed a dramatic increase in the culture medium of the TNF-alpha protein, an effect thereafter followed by an increase of nitric oxide synthase type 2 (NOS2) mRNA and, at later times, of nitrite accumulation, an index of nitric oxide (NO) production. Nitrites 213-220 tumor necrosis factor Rattus norvegicus 81-90 15097014-3 2004 METHODS: We examined nitrosatable drug exposure and NTD-affected pregnancies in relation to dietary nitrite and total nitrite intake in a case-control study of Mexican American women. Nitrites 100-107 fuzzy planar cell polarity protein Homo sapiens 52-55 15097014-8 2004 Women within the highest tertile (greater than 10.5 mg/day) of total nitrite were 7.5 times more likely to have an NTD-affected pregnancy if they took nitrosatable drugs (95% CI = 1.8-45.4). Nitrites 69-76 fuzzy planar cell polarity protein Homo sapiens 115-118 15354951-8 2004 Another oxide of nitrogen, nitrite, is a good substrate for myeloperoxidase Compound I but slowly reacts with Compound II. Nitrites 27-34 myeloperoxidase Homo sapiens 60-75 15354951-9 2004 Nitrogen dioxide is formed after nitrite oxidation by myeloperoxidase. Nitrites 33-40 myeloperoxidase Homo sapiens 54-69 15086905-5 2004 A protein tyrosine kinase inhibitor (genistein), or a p38 mitogen-activated protein kinase (MAPK) inhibitor (SB203580) suppressed AGE-induced iNOS expression and nitrite release from mesangial cells. Nitrites 162-169 mitogen-activated protein kinase 14 Homo sapiens 54-57 15086905-7 2004 Activation of PPAR-gamma by rosiglitazone inhibited AGE-induced iNOS expression, nitrite release, and p38 MAPK activation in mesangial cells. Nitrites 81-88 peroxisome proliferator activated receptor gamma Homo sapiens 14-24 15086905-8 2004 AGE-stimulated nitrite release was attenuated by pretreatment with anti-tumor necrosis factor-alpha (TNF-alpha) and anti-transforming growth factor-beta (TGF-beta) antibodies. Nitrites 15-22 tumor necrosis factor Homo sapiens 101-110 15080699-1 2004 Previous investigations of nitrite and nitric oxide reduction by myoglobin in surfactant film modified electrodes characterized several distinct steps in the denitrification pathway, including isolation of a nitroxyl adduct similar to that proposed in the P450nor catalytic cycle. Nitrites 27-34 myoglobin Homo sapiens 65-74 15158691-6 2004 MCF-7 cells transduced with inducible nitric oxide synthase gene (iNOS) through an adenoviral vector overexpressed iNOS and produced increased amounts of nitrite, an indicator of increased *NO production. Nitrites 154-161 nitric oxide synthase 2 Homo sapiens 66-70 15050440-1 2004 The findings of various studies reporting temporal changes in CSF total nitrite/nitrate (NOx) levels after subarachnoid hemorrhage (SAH) vary considerably. Nitrites 72-79 colony stimulating factor 2 Homo sapiens 62-65 18969390-10 2004 The method was successfully applied to the determination of low levels of nitrite in different water samples (river, fountain, tap and commercial drinking waters). Nitrites 74-81 nuclear RNA export factor 1 Homo sapiens 127-130 15013844-5 2004 Half maximal inhibition of interferon-gamma/lipopolysaccharide induced nitrite accumulation in murine macrophages required about 0.5 mM of the flavonoid. Nitrites 71-78 interferon gamma Mus musculus 27-43 15044069-4 2004 SNAP and SIN-1, but not SNP, elicited dramatic increases in media nitrite and intracellular NOx-related fluorescence from cells preloaded with a NOx indicator. Nitrites 66-73 mitogen-activated protein kinase associated protein 1 Mus musculus 9-14 14665447-12 2004 Expressions of endothelial NOS protein and NOx, the stable end product of NO, i.e., nitrite/nitrate, concentration in the kidney were significantly lower in the vehicle-treated exercise group than in the vehicle-treated sedentary group, whereas those in the TA-0201-treated exercise group were significantly higher than those in the vehicle-treated exercise group. Nitrites 84-91 nitric oxide synthase 3 Rattus norvegicus 15-30 15025513-2 2004 We report here that treatment of glycine ethyl ester at 37 degrees C with excess nitrite acidified with HCl, followed by ether extraction, gave 30-40% yields of a product identified as ethyl chloro(hydroximino)acetate [ClC(=NOH)COOEt, ECHA] and a 9% yield of ethyl chloroacetate. Nitrites 81-88 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Homo sapiens 235-239 14681238-4 2004 Exposure of fibrinogen to nitrating oxidants, including those produced by the myeloperoxidase-hydrogen peroxide-nitrite system, significantly accelerates clot formation and factor XIII cross-linking, whereas exposure of fibrinogen to non-nitrating oxidants decelerates clot formation. Nitrites 112-119 fibrinogen beta chain Homo sapiens 12-22 14681238-4 2004 Exposure of fibrinogen to nitrating oxidants, including those produced by the myeloperoxidase-hydrogen peroxide-nitrite system, significantly accelerates clot formation and factor XIII cross-linking, whereas exposure of fibrinogen to non-nitrating oxidants decelerates clot formation. Nitrites 112-119 fibrinogen beta chain Homo sapiens 220-230 14734648-6 2004 Urinary and plasma concentrations of nitrites, a NO metabolite, were lower in Eng+/- than in Eng+/+ mice. Nitrites 37-45 endoglin Mus musculus 78-81 14734648-6 2004 Urinary and plasma concentrations of nitrites, a NO metabolite, were lower in Eng+/- than in Eng+/+ mice. Nitrites 37-45 endoglin Mus musculus 93-96 15135362-0 2004 Interleukin-1beta up-regulates nitrite production: effects on ovarian function. Nitrites 31-38 interleukin 1 beta Rattus norvegicus 0-17 14980701-3 2004 In this work we show that also metmyoglobin and methemoglobin can nitrate free tyrosine in the presence of nitrite and H(2)O(2). Nitrites 107-114 hemoglobin subunit gamma 2 Homo sapiens 48-61 15076232-5 2004 Nitrite was quantified as a measure for inducible nitric oxide synthase (iNOS) activity. Nitrites 0-7 nitric oxide synthase 2 Homo sapiens 40-71 15076232-5 2004 Nitrite was quantified as a measure for inducible nitric oxide synthase (iNOS) activity. Nitrites 0-7 nitric oxide synthase 2 Homo sapiens 73-77 15135364-5 2004 In RINm5F cells, transfected with NOS2-specific small interfering RNA followed by a 12 h exposure to cytokines, there was a significant reduction in NOS2 protein, nitrite, and apoptosis. Nitrites 163-170 nitric oxide synthase 2 Rattus norvegicus 34-38 14707155-7 2004 Acetylcholine (ACh)-induced relaxation of Phe contraction and vascular eNOS protein and nitrite/nitrate production were less in IL-6-infused than in control pregnant rats. Nitrites 88-95 interleukin 6 Rattus norvegicus 128-132 15803717-5 2004 The immobilized Mb displays the features of a peroxidase and acts in an electrocatalytic manner in the reduction of oxygen, trichloroacetic acid (TCA), and nitrite. Nitrites 156-163 myoglobin Homo sapiens 16-18 14757118-6 2004 Interleukin-1 beta-induced nitrite production was twofold increased by 0.05 microM cerivastatin, and this effect could be reversed by addition of 100 microM mevalonate. Nitrites 27-34 interleukin 1 beta Rattus norvegicus 0-18 14968431-0 2004 The role of Ynt1 in nitrate and nitrite transport in the yeast Hansenula polymorpha. Nitrites 32-39 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 12-16 14968431-4 2004 Nitrite uptake in a wild-type strain was partially inhibited by nitrate to levels shown by a YNT1-disrupted strain in which, in turn, nitrite transport was not inhibited by nitrate. Nitrites 0-7 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 93-97 14968431-4 2004 Nitrite uptake in a wild-type strain was partially inhibited by nitrate to levels shown by a YNT1-disrupted strain in which, in turn, nitrite transport was not inhibited by nitrate. Nitrites 134-141 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 93-97 14968431-5 2004 It is concluded that nitrite uptake takes place by two different transport systems: Ynt1 and a nitrite-specific transporter(s). Nitrites 21-28 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 84-88 14968431-7 2004 Ynt1 presents its optimal rate for nitrite uptake at pH 6, while pH 4 was optimal for the specific nitrite uptake system(s). Nitrites 35-42 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 0-4 14968431-7 2004 Ynt1 presents its optimal rate for nitrite uptake at pH 6, while pH 4 was optimal for the specific nitrite uptake system(s). Nitrites 99-106 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 0-4 14968431-8 2004 At pH 5.5, the contribution of Ynt1 to high-affinity nitrate and nitrite uptake was around 95% and 60%, respectively. Nitrites 65-72 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 31-35 14968431-9 2004 The apparent Km of Ynt1 for nitrate and nitrite is in the microM range, as is the specific nitrite uptake system for nitrite. Nitrites 40-47 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 19-23 14968431-9 2004 The apparent Km of Ynt1 for nitrate and nitrite is in the microM range, as is the specific nitrite uptake system for nitrite. Nitrites 91-98 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 19-23 14968431-9 2004 The apparent Km of Ynt1 for nitrate and nitrite is in the microM range, as is the specific nitrite uptake system for nitrite. Nitrites 91-98 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 19-23 14968431-10 2004 The analysis of the effect of the reduced nitrogen sources on nitrate assimilation revealed that glutamine inactivates nitrate and nitrite transport, dependent on Ynt1, but not the nitrite-specific system. Nitrites 131-138 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 163-167 14717588-0 2004 Albumin oxidation to diverse radicals by the peroxidase activity of Cu,Zn-superoxide dismutase in the presence of bicarbonate or nitrite: diffusible radicals produce cysteinyl and solvent-exposed and -unexposed tyrosyl radicals. Nitrites 129-136 superoxide dismutase 1 Homo sapiens 68-94 14717588-9 2004 Overall, the results prove the diffusible and radical nature of the oxidants produced during the peroxidase activity of Cu,Zn-SOD in the presence of bicarbonate or nitrite. Nitrites 164-171 superoxide dismutase 1 Homo sapiens 120-129 14678790-0 2004 Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration. Nitrites 39-46 cytochrome c, somatic Homo sapiens 0-12 14700515-6 2004 RESULTS: Infection of neuronal cells with Ad-eNOS increased the nitrite production but decreased the level of superoxide anion (O(2)(-)), indicating that eNOS gene delivery increased NO availability. Nitrites 64-71 nitric oxide synthase 3 Rattus norvegicus 45-49 14700515-6 2004 RESULTS: Infection of neuronal cells with Ad-eNOS increased the nitrite production but decreased the level of superoxide anion (O(2)(-)), indicating that eNOS gene delivery increased NO availability. Nitrites 64-71 nitric oxide synthase 3 Rattus norvegicus 154-158 14678790-3 2004 We report herein a novel function for cytochrome c as a catalyst for nitrite (NO2-) and hydrogen peroxide (H2O2)-mediated nitration reactions. Nitrites 69-76 cytochrome c, somatic Homo sapiens 38-50 14657615-5 2004 Nitrites accumulated in supernatants of SMC cultures were measured as an index of NO released following treatment with IL-1beta. Nitrites 0-8 interleukin 1 beta Homo sapiens 119-127 15199233-1 2004 Nitrite and nitrate are widely used reporters of endogenous nitric oxide (NO) and nitric oxide synthase (NOS) activity, which are crucial for a broad spectrum of physiological and pathophysiological pathways. Nitrites 0-7 nitric oxide synthase 2 Homo sapiens 82-103 15199238-1 2004 Measurement of the nitric oxide (NO) metabolites nitrite and nitrate in biological matrices is a reliable method to assess NO synthase (NOS) activity. Nitrites 49-56 nitric oxide synthase 2 Homo sapiens 123-134 15588129-2 2004 In the presence of NADH or NADPH, diaphorase can convert selected NO donors, glycerol trinitrate (GTN) and formaldoxime (FAL) to nitrites and nitrates with NO as an intermediate. Nitrites 129-137 dihydrolipoamide dehydrogenase Homo sapiens 34-44 14643177-0 2004 Epidermal growth factor modulation of prostaglandins and nitrite biosynthesis in rat fetal membranes. Nitrites 57-64 epidermal growth factor like 1 Rattus norvegicus 0-23 15478859-7 2004 The level of nitrite accumulation rose in the culture of cells isolated from heifers with BRTI from 4+/-0.53 microM after 0.5h to 6.9+/-0.52 microM after 72 h. Our data suggest that during BRTI the increase of neutrophil secretory action results in augmentation of enzyme release including elastase, MPO and ALK-P, and the nitrite production. Nitrites 13-20 myeloperoxidase Bos taurus 300-303 14643177-3 2004 The aim of the present study was to investigate the effect of EGF in vivo on the PGs and nitrite production of rat fetal membranes. Nitrites 89-96 epidermal growth factor like 1 Rattus norvegicus 62-65 15303730-1 2004 The aim of the present work was to evaluate the performance of a semi-pilot scale BAF in order to obtain a highly polished effluent in terms of removal of organic matter, suspended solids and ammonia and to observe the influence of temperature, pH and nitrite accumulation on the nitrification process. Nitrites 252-259 BAF nuclear assembly factor 1 Homo sapiens 82-85 14657339-8 2003 Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production. Nitrites 207-214 nitric oxide synthase 2 Homo sapiens 28-32 14657339-8 2003 Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production. Nitrites 207-214 myeloperoxidase Homo sapiens 47-50 14657339-8 2003 Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production. Nitrites 207-214 nitric oxide synthase 2 Homo sapiens 106-110 12907425-7 2003 BBS-2 treatment blocked NOS2 dimerization and completely inhibited the endotoxin-induced increase of plasma nitrate and nitrite levels. Nitrites 120-127 Bardet-Biedl syndrome 2 (human) Mus musculus 0-5 14568906-3 2003 In addition, tissue concentrations of nitrite and nitrate were significantly increased in rats transfected with the eNOS gene up to 2 weeks after transfection. Nitrites 38-45 nitric oxide synthase 3 Rattus norvegicus 116-120 15028566-6 2003 NOS-2 activity was assessed after 24 hours by nitrite accumulation in the culture media. Nitrites 46-53 nitric oxide synthase 2, inducible Mus musculus 0-5 12962704-8 2003 On the other hand, sodium nitroprusside (SNP) and nitrites inhibit rhodanese activity only in the presence of thiols, which suggests that S-nitrosothiols (RSNO) also have to participate in this reaction in this case. Nitrites 50-58 thiosulfate sulfurtransferase Bos taurus 67-76 14642608-8 2003 Administration of NCX-1000 to BDL and sham operated rats resulted in a similar increase of nitrite/nitrate and cGMP concentrations in the liver. Nitrites 91-98 solute carrier family 8 member A1 Rattus norvegicus 18-21 14659696-3 2003 Several reactions mediate protein nitration, and all predominantly depend on z.rad;NO- and nitrite-dependent formation of nitrogen dioxide, a species capable of nitrating aromatic amino acids, nucleotides and unsaturated fatty acids. Nitrites 91-98 RRAD, Ras related glycolysis inhibitor and calcium channel regulator Homo sapiens 79-82 14642697-7 2003 The incubation of HUVECs and BAECs with ox-LDL reduced basal and bradykinin-induced NO and nitrite concentration (p from <0.001 to <0.01). Nitrites 91-98 kininogen 1 Bos taurus 65-75 14679069-4 2003 Incubation of MIN6 cells with IL-1beta, IFN-gamma, and TNF-alpha (cytomix) increased production of nitrites, with increased expression of iNOS mRNA. Nitrites 99-107 interleukin 1 beta Mus musculus 30-38 14679069-4 2003 Incubation of MIN6 cells with IL-1beta, IFN-gamma, and TNF-alpha (cytomix) increased production of nitrites, with increased expression of iNOS mRNA. Nitrites 99-107 interferon gamma Mus musculus 40-49 14679069-4 2003 Incubation of MIN6 cells with IL-1beta, IFN-gamma, and TNF-alpha (cytomix) increased production of nitrites, with increased expression of iNOS mRNA. Nitrites 99-107 tumor necrosis factor Mus musculus 55-64 14679069-5 2003 When treated with cytomix, the DN NF-kappaB-transfected mutant demonstrated significantly less nitrite production and apoptosis than parent MIN6. Nitrites 95-102 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 34-43 12960269-5 2003 In the presence of hydrogen peroxide and nitrite (NO2-; hereafter called EPO with substrates), EPO catalyzes the formation of nitrogen dioxide. Nitrites 41-48 eosinophil peroxidase Homo sapiens 73-76 14576508-4 2003 Incubation of cultures with interleukin (IL)-1beta (10 ng/mL) caused a significant increase in nitrite production. Nitrites 95-102 interleukin 1 beta Rattus norvegicus 28-50 14576508-5 2003 C-reactive protein significantly decreased the IL-1beta-induced nitrite production by VSMCs in a dose-dependent manner (10-100 microg/mL). Nitrites 64-71 C-reactive protein Rattus norvegicus 0-18 14576508-5 2003 C-reactive protein significantly decreased the IL-1beta-induced nitrite production by VSMCs in a dose-dependent manner (10-100 microg/mL). Nitrites 64-71 interleukin 1 beta Rattus norvegicus 47-55 12960269-5 2003 In the presence of hydrogen peroxide and nitrite (NO2-; hereafter called EPO with substrates), EPO catalyzes the formation of nitrogen dioxide. Nitrites 41-48 eosinophil peroxidase Homo sapiens 95-98 13679077-5 2003 Another potential source of reactive nitrogen species is the myeloperoxidase-hydrogen peroxide-nitrite system of activated phagocytes. Nitrites 95-102 myeloperoxidase Homo sapiens 61-76 14521929-2 2003 Because nitrites produce nitric oxide, we hypothesized that their toxicological effects might be partly mediated via regulation of angiogenic factors such as vascular endothelial growth factor (VEGF). Nitrites 8-16 vascular endothelial growth factor A Mus musculus 158-192 14521929-2 2003 Because nitrites produce nitric oxide, we hypothesized that their toxicological effects might be partly mediated via regulation of angiogenic factors such as vascular endothelial growth factor (VEGF). Nitrites 8-16 vascular endothelial growth factor A Mus musculus 194-198 14521929-6 2003 These results demonstrate that in vivo exposure to an inhalant nitrite results in altered tissue expression of VEGF and its receptors, suggesting that some of its toxicological effects may be mediated partly through a mechanism involving angiogenesis. Nitrites 63-70 vascular endothelial growth factor A Mus musculus 111-115 14558624-8 2003 Under the optimum conditions, we monitored the changes in the concentration of the nitrite levels through synergistic stimulation of tumor necrosis factor alpha plus gamma-interferon in PC12 cells. Nitrites 83-90 tumor necrosis factor Rattus norvegicus 133-160 13679077-9 2003 Xanthine nitration by myeloperoxidase required hydrogen peroxide and nitrite. Nitrites 69-76 myeloperoxidase Homo sapiens 22-37 14669994-4 2003 We demonstrate that ADP-ribosylation inhibitors specifically inhibit ERK MAPK activation and reduce the release of inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), IL-6 and nitrite. Nitrites 196-203 mitogen-activated protein kinase 1 Mus musculus 69-72 12971945-0 2003 Human salivary peroxidase-catalyzed oxidation of nitrite and nitration of salivary components 4-hydroxyphenylacetic acid and proteins. Nitrites 49-56 lactoperoxidase Homo sapiens 6-25 12971945-3 2003 H2O2-dependent oxidation of nitrite and H2O2-dependent nitration of HPA were observed in dialyzed saliva and by partially purified salivary peroxidase (SPX). Nitrites 28-35 lactoperoxidase Homo sapiens 131-150 12971945-3 2003 H2O2-dependent oxidation of nitrite and H2O2-dependent nitration of HPA were observed in dialyzed saliva and by partially purified salivary peroxidase (SPX). Nitrites 28-35 lactoperoxidase Homo sapiens 152-155 14583343-1 2003 Changes in plasma nitrite concentration in the human forearm circulation have recently been shown to reflect acute changes in endothelial nitric oxide synthase (eNOS)-activity. Nitrites 18-25 nitric oxide synthase 3 Homo sapiens 126-159 12912858-11 2003 CO also significantly decreased serum nitrite levels (iNOS activity). Nitrites 38-45 nitric oxide synthase 2 Rattus norvegicus 54-58 13678668-6 2003 The interaction of TNFalpha, IL6, and IFNgamma proteins was modeled in vitro using Walker EOC-20 murine microglia with nitrite (NO(2)(-)) efflux as a quantitative index of cell response. Nitrites 119-126 interferon gamma Mus musculus 38-46 12960352-5 2003 We show in this study that IFN-gamma induced iNOS protein expression (by 50-fold from control, p < 0.01) and nitrite accumulation (71.6 +/- 14 micro M, p < 0.01 relative to control), and that hypoxia inhibited NO production (7.6 +/- 1.7 micro M, p < 0.01) without altering iNOS protein expression. Nitrites 112-119 interferon gamma Mus musculus 27-36 14512099-3 2003 In SHR, the NCX 4016 treatment increased the serum nitrite/nitrate and diminished the serum thromboxane B2, whereas aspirin did not change blood pressure but abolished the serum thromboxane B2. Nitrites 51-58 solute carrier family 8 member A1 Rattus norvegicus 12-15 12911628-3 2003 Application of IFN-gamma followed by LPS caused dopaminergic cell death and accompanying increases in nitrite production and lactate dehydrogenase release. Nitrites 102-109 interferon gamma Rattus norvegicus 15-24 12935887-5 2003 The oxygen uptake by the AA/nitrite/SCN(-) system was also observed in an acidic buffer solution. Nitrites 28-35 sorcin Homo sapiens 36-39 12899636-0 2003 The tetraheme cytochrome CymA is required for anaerobic respiration with dimethyl sulfoxide and nitrite in Shewanella oneidensis. Nitrites 96-103 cytochrome c Shewanella oneidensis MR-1 25-29 12899636-8 2003 We also demonstrate that CymA is essential for growth with DMSO (dimethyl sulfoxide) and for reduction of nitrite, implicating CymA in at least five different electron transfer pathways in Shewanella. Nitrites 106-113 cytochrome c Shewanella oneidensis MR-1 25-29 12879250-12 2003 Finally, also a diminished production of systemic nitrite levels was observed in AsA- and IL-1ra-treated islet recipients. Nitrites 50-57 interleukin 1 receptor antagonist Mus musculus 90-96 12899636-8 2003 We also demonstrate that CymA is essential for growth with DMSO (dimethyl sulfoxide) and for reduction of nitrite, implicating CymA in at least five different electron transfer pathways in Shewanella. Nitrites 106-113 cytochrome c Shewanella oneidensis MR-1 127-131 12966985-6 2003 Microcosm studies using a DNT-degrading culture from column effluent suggest that, after the onset of 2,4-DNT degradation, nitrite evolution will eventually control the extent of degradation achieved by two mechanisms. Nitrites 123-130 5', 3'-nucleotidase, cytosolic Homo sapiens 26-29 12884303-7 2003 The protective effect of IL-18 bp:Fc was accompanied by modified ex vivo immune responses, in that spleen cells and peritoneal macrophages contained fewer IFN-gamma secreting cells and released lower amounts of nitrite (an index of nitric oxide production) and IL-1beta. Nitrites 211-218 interleukin 18 binding protein Mus musculus 25-33 12873449-0 2003 Reduction of nitrite production by endothelin-1 in isolated porcine ciliary processes. Nitrites 13-20 endothelin 1 Homo sapiens 35-47 12966985-7 2003 First, high levels of nitrite (40 mM) were found to strongly inhibit 2,4-DNT degradation. Nitrites 22-29 5', 3'-nucleotidase, cytosolic Homo sapiens 73-76 12873449-2 2003 This study investigates whether endothelin-1 can reduce the production of nitrite (a stable metabolite of NO) in isolated porcine ciliary processes. Nitrites 74-81 endothelin 1 Homo sapiens 32-44 12873449-5 2003 In a concentration-dependent manner (0.1 nM to 1 microM), endothelin-1 significantly decreased basal nitrite production (1 microM: 81.7+/-3.5%; P<0.001). Nitrites 101-108 endothelin 1 Homo sapiens 58-70 12966985-8 2003 Second, nitrite production reduces the solution pH, and at pH levels below 6.0, 2,4-DNT degradation slows rapidly. Nitrites 8-15 5', 3'-nucleotidase, cytosolic Homo sapiens 84-87 12873449-9 2003 The inhibitory effect of endothelin-1 on forskolin-induced nitrite production was significantly reversed by BQ123 (1 microM: 132.4+/-5.1%; P<0.01), but not by BQ788 (1 microM: 112.7+/-4.1%; P=0.64) or unoprostone (30 microM: 109.3+/-4.8%; P=0.98). Nitrites 59-66 endothelin 1 Homo sapiens 25-37 12967034-0 2003 Naringin and naringenin inhibit nitrite-induced methemoglobin formation. Nitrites 32-39 hemoglobin subunit gamma 2 Homo sapiens 48-61 12873449-10 2003 These results suggest that endothelin-1, through an ETA receptor activation, can reduce both basal and forskolin-induced nitrite production in isolated porcine ciliary processes. Nitrites 121-128 endothelin 1 Homo sapiens 27-39 12873449-10 2003 These results suggest that endothelin-1, through an ETA receptor activation, can reduce both basal and forskolin-induced nitrite production in isolated porcine ciliary processes. Nitrites 121-128 endothelin receptor type A Homo sapiens 52-55 14559427-10 2003 Incubation of L2 cells with a mixture of interferon gamma (IFNgamma), lipopolysaccharide (LPS), and tumor necrosis factor (TNFalpha) resulted in high levels of nitrite formation resulting from iNOS induction. Nitrites 160-167 interferon gamma Rattus norvegicus 41-57 14559427-10 2003 Incubation of L2 cells with a mixture of interferon gamma (IFNgamma), lipopolysaccharide (LPS), and tumor necrosis factor (TNFalpha) resulted in high levels of nitrite formation resulting from iNOS induction. Nitrites 160-167 interferon gamma Rattus norvegicus 59-67 14559427-10 2003 Incubation of L2 cells with a mixture of interferon gamma (IFNgamma), lipopolysaccharide (LPS), and tumor necrosis factor (TNFalpha) resulted in high levels of nitrite formation resulting from iNOS induction. Nitrites 160-167 tumor necrosis factor Rattus norvegicus 123-131 14559427-10 2003 Incubation of L2 cells with a mixture of interferon gamma (IFNgamma), lipopolysaccharide (LPS), and tumor necrosis factor (TNFalpha) resulted in high levels of nitrite formation resulting from iNOS induction. Nitrites 160-167 nitric oxide synthase 2 Rattus norvegicus 193-197 12834739-7 2003 This observation suggested that in addition to the two well-accepted groups of phosphorus removal bacteria (one can only utilize oxygen to take up phosphorus, P(O), while the other can use both oxygen and nitrate, P(ON)), a new group of phosphorus removal bacteria, P(ON(n)), which could use oxygen, nitrate or nitrite to take up phosphorus was identified. Nitrites 311-318 paraoxonase 1 Homo sapiens 214-219 12869138-4 2003 When stimulated with IFN-gamma, culture supernatants from young PMs contained higher amounts of nitrite and TNF-alpha. Nitrites 96-103 interferon gamma Rattus norvegicus 21-30 12878034-7 2003 The biological implication of drug activation by LPO with nitrite is discussed. Nitrites 58-65 lactoperoxidase Homo sapiens 49-52 12818368-3 2003 Upon stimulation with 1 microg/mL lipopolysaccharide plus 100 U/mL interferon-gamma which induced the expression of inducible nitric oxide synthase, cultured astrocytes generated large amounts of NO as measured by nitrite assay and ESR technique. Nitrites 214-221 nitric oxide synthase 2 Rattus norvegicus 116-147 12839867-6 2003 In differentiated 3T3-F442A, treatment with TNFalpha (20 ng ml(-1)) induced the expression of a functional iNOS as demonstrated by nitrite assay, Western blot, reverse transcription-polymerase chain reaction and Northern blot analysis. Nitrites 131-138 tumor necrosis factor Mus musculus 44-52 12839867-6 2003 In differentiated 3T3-F442A, treatment with TNFalpha (20 ng ml(-1)) induced the expression of a functional iNOS as demonstrated by nitrite assay, Western blot, reverse transcription-polymerase chain reaction and Northern blot analysis. Nitrites 131-138 nitric oxide synthase 2, inducible Mus musculus 107-111 12839867-9 2003 ET-1, but not ET-3, inhibited the TNFalpha-induced expression of iNOS protein and mRNA as well as nitrite production. Nitrites 98-105 endothelin 1 Mus musculus 0-4 12839867-9 2003 ET-1, but not ET-3, inhibited the TNFalpha-induced expression of iNOS protein and mRNA as well as nitrite production. Nitrites 98-105 tumor necrosis factor Mus musculus 34-42 12690103-1 2003 A significant increase in the induction of inducible nitric-oxide synthase (iNOS) protein expression and in the levels of nitrite plus nitrate was observed in rat aortic smooth muscle cells (RASMCs) stably transfected with catalase (RASMC-2C2) as compared with empty vector-transfected RASMC-V4 cells after exposure to cytokines and lipopolysaccharide. Nitrites 122-129 catalase Rattus norvegicus 223-231 12804571-8 2003 The effects of formate on ATPase activity disappeared when cells were performing anaerobic (nitrate/nitrite) or aerobic respiration. Nitrites 100-107 ATPase Escherichia coli 26-32 12943506-0 2003 Nitrite-catalase interaction as an important element of nitrite toxicity. Nitrites 56-63 catalase Homo sapiens 8-16 12943506-1 2003 It was established that nitrite in the presence of chloride, bromide, and thiocyanate decreases the rate of hydrogen peroxide decomposition by catalase. Nitrites 24-31 catalase Homo sapiens 143-151 12943506-4 2003 These facts suggest that nitrite induces inhibition of catalase with no change in the essence of the enzymatic process. Nitrites 25-32 catalase Homo sapiens 55-63 12943506-5 2003 Even micromolar nitrite concentrations induced a considerable decrease in catalase activity. Nitrites 16-23 catalase Homo sapiens 74-82 12943506-7 2003 In contrast, fluoride protected catalase from nitrite inhibition in the presence of the above-mentioned halides and pseudohalide. Nitrites 46-53 catalase Homo sapiens 32-40 12943506-8 2003 As hydrogen peroxide is a necessary factor for triggering a number of important toxic effects of nitrite, the latter increases its toxicity by inhibiting catalase. Nitrites 97-104 catalase Homo sapiens 154-162 12943506-10 2003 The naturally existing gradient of chloride and other anion concentrations between intra- and extracellular media appears to be the most important mechanism of cell protection from inhibition of intracellular catalase by nitrite. Nitrites 221-228 catalase Homo sapiens 209-217 12805624-6 2003 Accordingly, nitrite (NO2-) strongly represses NRT1.1 and NIA1 transcript accumulation in the roots. Nitrites 13-20 nitrate transporter 1.1 Arabidopsis thaliana 47-51 12892378-6 2003 Concomitantly, plasma NO products (nitrate + nitrite), which increased 2.2-fold during Mg-deficiency, were completely suppressed by the SPR blockade. Nitrites 45-52 sepiapterin reductase Rattus norvegicus 136-139 12805624-6 2003 Accordingly, nitrite (NO2-) strongly represses NRT1.1 and NIA1 transcript accumulation in the roots. Nitrites 13-20 nitrate reductase 1 Arabidopsis thaliana 58-62 12736051-5 2003 The proposed method has been successfully applied to the determination of nitrite in tap water and lake water without extraction. Nitrites 74-81 nuclear RNA export factor 1 Homo sapiens 85-88 12782181-3 2003 Exposure of A498 cells to a cytokine mixture consisting of interferon gamma, interleukin-1 beta and tumor necrosis factor-alpha (TNF-alpha) increased nitrite production, iNOS mRNA and protein expression. Nitrites 150-157 interferon gamma Homo sapiens 59-75 12820230-5 2003 Nitrite accumulation in culture medium and apoptosis of MC3T3-E1 cells were induced by the addition of 10(-10) M TNF-alpha, and inhibited by the simultaneous addition of soy extract (0.05g/L). Nitrites 0-7 tumor necrosis factor Mus musculus 113-122 12782181-3 2003 Exposure of A498 cells to a cytokine mixture consisting of interferon gamma, interleukin-1 beta and tumor necrosis factor-alpha (TNF-alpha) increased nitrite production, iNOS mRNA and protein expression. Nitrites 150-157 interleukin 1 beta Homo sapiens 77-95 12782181-8 2003 Furthermore, the NF-kappa B inhibitor pyrrolidinedithiocarbamate (PDTC) decreased cytokine-activated iNOS protein expression and nitrite production. Nitrites 129-136 nuclear factor kappa B subunit 1 Homo sapiens 17-27 12782181-3 2003 Exposure of A498 cells to a cytokine mixture consisting of interferon gamma, interleukin-1 beta and tumor necrosis factor-alpha (TNF-alpha) increased nitrite production, iNOS mRNA and protein expression. Nitrites 150-157 tumor necrosis factor Homo sapiens 100-127 12782181-3 2003 Exposure of A498 cells to a cytokine mixture consisting of interferon gamma, interleukin-1 beta and tumor necrosis factor-alpha (TNF-alpha) increased nitrite production, iNOS mRNA and protein expression. Nitrites 150-157 tumor necrosis factor Homo sapiens 129-138 12782181-4 2003 Pharmacological inhibition of tyrosine kinases, including janus kinase (JAK2), and protein kinase C (PKC) inhibited cytokine-mediated nitrite production and iNOS protein expression. Nitrites 134-141 Janus kinase 2 Homo sapiens 72-76 12562562-8 2003 High tidal volume ventilation also increased lung inducible nitric oxide synthase (NOS2) expression and air space total nitrite at 3 h. Inhibition of NOS2 activity preserved cAMP-dependent AFC. Nitrites 120-127 nitric oxide synthase 2 Rattus norvegicus 150-154 12521994-5 2003 In keeping with the sensitivity of Fancc(-/-) cells to IFNgamma, inducible nitric oxide synthase (iNOS) levels and nitrite release were both increased following stimulation of Fancc(-/-) macrophages with this cytokine, either alone or in combination with bacterial lipopolysaccharide. Nitrites 115-122 Fanconi anemia, complementation group C Mus musculus 176-181 12727333-5 2003 Low levels of wt alpha-synuclein blocked H(2)O(2)-induced cytotoxicity and nitrite production, a protective effect that was partly decreased upon higher expression. Nitrites 75-82 synuclein alpha Homo sapiens 17-32 12797467-1 2003 Myeloperoxidase (MPO) catalyzes a nitration reaction to form nitrotyrosine in the presence of high nitrite, the metabolite of NO. Nitrites 99-106 myeloperoxidase Homo sapiens 0-15 12797467-1 2003 Myeloperoxidase (MPO) catalyzes a nitration reaction to form nitrotyrosine in the presence of high nitrite, the metabolite of NO. Nitrites 99-106 myeloperoxidase Homo sapiens 17-20 12797467-2 2003 Human leukocyte was shown to cause phenolic nitration using released MPO as a catalyst in the presence of nitrite. Nitrites 106-113 myeloperoxidase Homo sapiens 69-72 12797467-10 2003 We conclude that MPO may act predominantly to scavenge nitrotyrosine under physiological nitrite condition, and protect against injurious effect of nitrotyrosine. Nitrites 89-96 myeloperoxidase Homo sapiens 17-20 12686872-10 2003 This change in erectile function was a result of eNOS over expression with an increase in eNOS protein expression and constitutive NOS activity as well as an increase in nitric oxide biosynthesis, as reflected by an increase in cavernous nitrate plus nitrite formation. Nitrites 251-258 nitric oxide synthase 3 Rattus norvegicus 49-53 14659339-7 2003 In the metastatic disease group, there was a positive correlation between serum VEGF levels and nitrate+nitrite levels (r=0.436, P<0.05). Nitrites 104-111 vascular endothelial growth factor A Homo sapiens 80-84 12686999-3 2003 Here we provide evidence for bacteria that anaerobically oxidize ammonium with nitrite to N2 in the world"s largest anoxic basin, the Black Sea. Nitrites 79-86 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 140-143 12620815-13 2003 strain DN22 catalyzed the release of two nitrite ions from each reacted RDX molecule. Nitrites 41-48 radixin Oryctolagus cuniculus 72-75 12667961-7 2003 CRP alone was a weak inducer of NO production in VSMC as measured by determining nitrite levels, and interferon-gamma alone was totally ineffective, whereas CRP plus interferon-gamma was a powerful stimulus. Nitrites 81-88 C-reactive protein Homo sapiens 0-3 12594738-4 2003 LPS significantly increased iNOS mRNA expression, peaking at 6 h, while nitrite formation increased with time up to 72 h. Although TNFalpha alone induced neither iNOS mRNA expression nor nitrite formation, it significantly potentiated the effect of LPS on both. Nitrites 72-79 tumor necrosis factor Homo sapiens 131-139 12719662-4 2003 Microglial production of nitrite, interleukin-6 and tumor necrosis factor-alpha was induced by Abeta40, but not Abeta42. Nitrites 25-32 interleukin 6 Homo sapiens 34-79 12615686-8 2003 Overexpression of G6PD was also associated with enhanced nitric oxide synthase activity, resulting in elevated levels of cGMP, nitrate, and nitrite, and this response was increased after stimulation with bradykinin. Nitrites 140-147 glucose-6-phosphate dehydrogenase Bos taurus 18-22 12615686-8 2003 Overexpression of G6PD was also associated with enhanced nitric oxide synthase activity, resulting in elevated levels of cGMP, nitrate, and nitrite, and this response was increased after stimulation with bradykinin. Nitrites 140-147 kininogen 1 Bos taurus 204-214 12628482-4 2003 At the same time, low levels of nitrite accumulated in the culture medium and expression of nitric oxide synthase-2 (NOS-2) and NOS-3 protein was detected. Nitrites 32-39 nitric oxide synthase 2, inducible Mus musculus 92-115 12628482-4 2003 At the same time, low levels of nitrite accumulated in the culture medium and expression of nitric oxide synthase-2 (NOS-2) and NOS-3 protein was detected. Nitrites 32-39 nitric oxide synthase 2, inducible Mus musculus 117-122 12628482-4 2003 At the same time, low levels of nitrite accumulated in the culture medium and expression of nitric oxide synthase-2 (NOS-2) and NOS-3 protein was detected. Nitrites 32-39 nitric oxide synthase 3, endothelial cell Mus musculus 128-133 12588513-5 2003 In contrast, IL-6 release was already significantly higher 6 h after stimulation and further increased at 24 h. The correlation between accumulated nitrite and secreted IL-6 was 0.84 after 24 h of incubation with LPS. Nitrites 148-155 interleukin 6 Mus musculus 13-17 12612415-0 2003 Modification by fluoride, bromide, iodide, thiocyanate and nitrite anions of reaction of a myeloperoxidase-H2O2-Cl- system with nucleosides. Nitrites 59-66 myeloperoxidase Homo sapiens 91-106 12588513-5 2003 In contrast, IL-6 release was already significantly higher 6 h after stimulation and further increased at 24 h. The correlation between accumulated nitrite and secreted IL-6 was 0.84 after 24 h of incubation with LPS. Nitrites 148-155 interleukin 6 Mus musculus 169-173 12584267-10 2003 Correspondingly, urinary nitrate/nitrite excretion was significantly elevated in ET-1 transgenic mice. Nitrites 33-40 endothelin 1 Mus musculus 81-85 12620644-6 2003 When cells were co-treated with increasing doses of rhGGF2 and PMA or IFNgamma, only concentrations of 50 ng/ml, but not 10 or 100 ng/ml, were able to decrease oxidative burst activity and nitrite release. Nitrites 189-196 interferon gamma Homo sapiens 70-78 12606047-1 2003 In the presence of a H(2)O(2)-generating system, myeloperoxidase (MPO) caused conjugated diene formation in low-density lipoprotein (LDL), indicating lipid peroxidation which was dependent on nitrite but not on chloride. Nitrites 192-199 myeloperoxidase Homo sapiens 49-64 12606047-1 2003 In the presence of a H(2)O(2)-generating system, myeloperoxidase (MPO) caused conjugated diene formation in low-density lipoprotein (LDL), indicating lipid peroxidation which was dependent on nitrite but not on chloride. Nitrites 192-199 myeloperoxidase Homo sapiens 66-69 12606047-0 2003 Myeloperoxidase/nitrite-mediated lipid peroxidation of low-density lipoprotein as modulated by flavonoids. Nitrites 16-23 myeloperoxidase Homo sapiens 0-15 12606047-4 2003 The MPO-catalyzed oxidation of flavonoids was accelerated in the presence of nitrite. Nitrites 77-84 myeloperoxidase Homo sapiens 4-7 12574380-3 2003 Group IIA PLA(2) stimulated iNOS expression and promoted nitrite production in a dose- and time-dependent manner in Raw264.7 cells. Nitrites 57-64 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 10-16 12574380-10 2003 However, site-directed mutation in residue responsible for PLA(2) catalytic activity markedly reduced their ability to production of nitrites and expression of iNOS. Nitrites 133-141 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 59-65 12574380-11 2003 These results suggest that group IIA PLA(2) induces nitrite production by involving of M-type sPLA(2)R, which then mediates signal transduction events that lead to PI3K/Akt activation. Nitrites 52-59 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 37-43 12574380-11 2003 These results suggest that group IIA PLA(2) induces nitrite production by involving of M-type sPLA(2)R, which then mediates signal transduction events that lead to PI3K/Akt activation. Nitrites 52-59 thymoma viral proto-oncogene 1 Mus musculus 169-172 12527339-6 2003 resulted in a significant reduction of the expression of iNOS protein in rat lung tissue and in the plasma nitrite/nitrate (NOx) level. Nitrites 107-114 nitric oxide synthase 2 Rattus norvegicus 57-61 12549937-10 2003 Thus, XOR catalyzed nitrate reduction to nitrite and NO occurs and can be an important source of NO production in ischemic tissues. Nitrites 41-48 xanthine dehydrogenase Homo sapiens 6-9 12524412-4 2003 NO derived nitrite excretion determined from a 24 hour sterile urine collection was correlated with intestinal macromolecular permeability (polyethylene glycol excretion ratio), markers of systemic endotoxin exposure (IgG:IgM endotoxin core antibody (EndoCAb) ratio), disease severity, and the magnitude of systemic inflammation (peak C reactive protein (CRP) and Acute Physiology and Chronic Health Evaluation score II (APACHE-II)). Nitrites 11-18 C-reactive protein Homo sapiens 335-353 12571850-3 2003 Then, iNOS activity was indirectly studied by measuring nitrite accumulation, using the Griess colorimetric reaction, in culture medium of human primary chondrocytes and ATDC5 cells. Nitrites 56-63 nitric oxide synthase 2 Homo sapiens 6-10 12543127-6 2003 Furthermore, iNOS activity (nitrite) was also reduced to 50%. Nitrites 28-35 nitric oxide synthase 2 Gallus gallus 13-17 12627879-4 2003 Pretreatment with ONO-RS-082, the secretory PLA2 (sPLA2) inhibitor, at 1 to 10 micromol/l reduced IL-1beta-stimulated nitrite production and iNOS expression. Nitrites 118-125 phospholipase A2 group IB Homo sapiens 44-48 12627879-4 2003 Pretreatment with ONO-RS-082, the secretory PLA2 (sPLA2) inhibitor, at 1 to 10 micromol/l reduced IL-1beta-stimulated nitrite production and iNOS expression. Nitrites 118-125 phospholipase A2 group IIA Homo sapiens 50-55 12627879-4 2003 Pretreatment with ONO-RS-082, the secretory PLA2 (sPLA2) inhibitor, at 1 to 10 micromol/l reduced IL-1beta-stimulated nitrite production and iNOS expression. Nitrites 118-125 interleukin 1 beta Homo sapiens 98-106 12627879-5 2003 Nordihydroguaiaretic acid (NDGA, 1 to 10 micromol/l), the LOX inhibitor, also reduced IL-1beta (10 ng/ml)-stimulated nitrite production and iNOS expression in a dose-dependent manner. Nitrites 117-124 interleukin 1 beta Homo sapiens 86-94 12627879-6 2003 Exogenous 12(S)-hydroxyeicosatetraenoic acids (HETE) enhanced the IL-1beta-stimulated nitrite production and iNOS expression. Nitrites 86-93 interleukin 1 beta Homo sapiens 66-74 12524412-4 2003 NO derived nitrite excretion determined from a 24 hour sterile urine collection was correlated with intestinal macromolecular permeability (polyethylene glycol excretion ratio), markers of systemic endotoxin exposure (IgG:IgM endotoxin core antibody (EndoCAb) ratio), disease severity, and the magnitude of systemic inflammation (peak C reactive protein (CRP) and Acute Physiology and Chronic Health Evaluation score II (APACHE-II)). Nitrites 11-18 C-reactive protein Homo sapiens 355-358 12563676-10 2003 The serum nitrite/nitrate levels, histological grades of articular cartilage degradation, and numbers of apoptotic chondrocytes and nitrotyrosine positive chondrocytes were significantly lower in NOS2-/- mice with AMA than in WT mice with AMA. Nitrites 10-17 nitric oxide synthase 2, inducible Mus musculus 196-200 12509805-6 2003 By contrast, the selective p38 kinase inhibitor SB203,580 amplified the effects of IL-1beta/TNF-alpha on nitrite accumulation. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 83-91 12509805-6 2003 By contrast, the selective p38 kinase inhibitor SB203,580 amplified the effects of IL-1beta/TNF-alpha on nitrite accumulation. Nitrites 105-112 tumor necrosis factor Rattus norvegicus 92-101 12494944-3 2003 The nitrite levels in urine of iNOS+/+ but not iNOS/ mice increased after infection. Nitrites 4-11 nitric oxide synthase 2, inducible Mus musculus 31-35 12488138-0 2002 Inhibition of human surfactant protein A function by oxidation intermediates of nitrite. Nitrites 80-87 surfactant protein A1 Homo sapiens 20-40 15055718-9 2003 On the other hand, long-term treatment with this AT1 receptor antagonist produced a significant increase of nitrate/nitrite and cGMP plasma levels. Nitrites 116-123 angiotensin II receptor, type 1a Rattus norvegicus 49-52 12500206-7 2003 Among ascitic patients, those with high LBP showed greater (P <.05) levels of sCD14, tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), nitrites + nitrates (NOx)/creatinine, and renin, and lower vascular resistance. Nitrites 151-159 lipopolysaccharide binding protein Homo sapiens 40-43 12488138-3 2002 We report here that a mixture of hypochlorous acid (HOCl) and nitrite (NO 2 - ) induces nitration, oxidation, and chlorination of tyrosine residues in human SP-A and inhibits SP-A"s ability to aggregate lipids and bind mannose. Nitrites 62-69 surfactant protein A1 Homo sapiens 157-161 12488138-3 2002 We report here that a mixture of hypochlorous acid (HOCl) and nitrite (NO 2 - ) induces nitration, oxidation, and chlorination of tyrosine residues in human SP-A and inhibits SP-A"s ability to aggregate lipids and bind mannose. Nitrites 62-69 surfactant protein A1 Homo sapiens 175-179 12440938-0 2002 Erythropoietin and interleukin-1beta modulate nitrite production in a Swiss 3T3 cell model of rheumatoid synovial fibroblasts. Nitrites 46-53 erythropoietin Mus musculus 0-14 12526099-2 2002 Adipocytes incubated with TNF induced dose- and time-dependent accumulation of nitrite in the culture medium through the iNOS induction as confirmed by Western blotting. Nitrites 79-86 tumor necrosis factor Homo sapiens 26-29 12526099-2 2002 Adipocytes incubated with TNF induced dose- and time-dependent accumulation of nitrite in the culture medium through the iNOS induction as confirmed by Western blotting. Nitrites 79-86 nitric oxide synthase 2 Homo sapiens 121-125 12526099-3 2002 Treatment of cells with TNF in the presence of all-trans-retinoic acid (RA) significantly decreased their ability to produce nitrite and iNOS induction. Nitrites 125-132 tumor necrosis factor Homo sapiens 24-27 12359714-4 2002 For example, MPO catalyzes oxidation of tyrosine and nitrite to form tyrosyl radical and nitrogen dioxide ((. Nitrites 53-60 myeloperoxidase Mus musculus 13-16 12376366-3 2002 Pulmonary cells that expressed hHO-1 exhibited a fourfold increase in HO activity associated with decreases in the steady-state levels of heme and cGMP without changes in soluble GC (sGC) and endothelial nitric oxide synthase (NOS) proteins or basal nitrite production. Nitrites 250-257 heme oxygenase 1 Homo sapiens 31-36 12440938-0 2002 Erythropoietin and interleukin-1beta modulate nitrite production in a Swiss 3T3 cell model of rheumatoid synovial fibroblasts. Nitrites 46-53 interleukin 1 beta Mus musculus 19-36 12440938-4 2002 The results show that, over 3 days, both alone and in combination with the pro-inflammatory cytokine IL-1beta (10 ng/ml), rHuEPO (25 micro-units/ml) induced significant production of nitrite in cell culture supernatants. Nitrites 183-190 interleukin 1 beta Mus musculus 101-109 12411410-5 2002 After 24 h of incubation, leptin (1-10 micro g ml(-1)) potently synergized with IFN-gamma (100 U ml(-1)) in nitric oxide (NO) release, evaluated as nitrite and nitrate (NO(x)), and prostaglandin E(2) (PGE(2)) production in culture medium. Nitrites 148-155 leptin Mus musculus 26-32 12411410-5 2002 After 24 h of incubation, leptin (1-10 micro g ml(-1)) potently synergized with IFN-gamma (100 U ml(-1)) in nitric oxide (NO) release, evaluated as nitrite and nitrate (NO(x)), and prostaglandin E(2) (PGE(2)) production in culture medium. Nitrites 148-155 interferon gamma Mus musculus 80-89 12377220-4 2002 The results show that ovotransferrin stimulates the production of IL-6, nitrite and MMP by HD11 cells and augments phorbol ester-induced respiratory burst. Nitrites 72-79 transferrin (ovotransferrin) Gallus gallus 22-36 12270552-3 2002 In this study, we show the varying concentrations of nitrite and nitrate present in different body fluids during AK-5 tumor growth and regression in Wistar rats. Nitrites 53-60 adenylate kinase isoenzyme 5 Rattus norvegicus 113-117 12296741-0 2002 Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase. Nitrites 43-50 cytochrome c, somatic Homo sapiens 65-77 12202921-5 2002 In 1/3 to 2/3 of the subjects tested, sodium nitrate or nitrite decreased production of Th1 cytokines (interleukin-2, interferon-gamma, and tumor necrosis factor-beta). Nitrites 56-63 negative elongation factor complex member C/D Homo sapiens 88-91 12202921-5 2002 In 1/3 to 2/3 of the subjects tested, sodium nitrate or nitrite decreased production of Th1 cytokines (interleukin-2, interferon-gamma, and tumor necrosis factor-beta). Nitrites 56-63 interleukin 2 Homo sapiens 103-116 12202921-5 2002 In 1/3 to 2/3 of the subjects tested, sodium nitrate or nitrite decreased production of Th1 cytokines (interleukin-2, interferon-gamma, and tumor necrosis factor-beta). Nitrites 56-63 interferon gamma Homo sapiens 118-166 12202921-8 2002 Because nitrate/nitrite shifted the balance from a Th1 to a Th2 response in some individuals, exposure to these compounds may decrease these persons" responsiveness to infectious diseases. Nitrites 16-23 negative elongation factor complex member C/D Homo sapiens 51-54 12296741-1 2002 Cytochrome c nitrite reductase catalyzes the six-electron reduction of nitrite to ammonia without the release of potential reaction intermediates, such as NO or hydroxylamine. Nitrites 13-20 cytochrome c, somatic Homo sapiens 0-12 12450113-0 2002 Appearance of nitrite reducing activity of cytochrome c upon heat denaturation. Nitrites 14-21 cytochrome c, somatic Equus caballus 43-55 12450070-8 2002 L-NAME (10(-4) M) partially inhibited nitrite release in both basal and Ang-II-stimulated S aortic rings. Nitrites 38-45 angiogenin Oryctolagus cuniculus 72-75 12237169-8 2002 RESULTS: Incubation of cardiac myocytes with interleukin-1beta (IL-1beta; 10 ng/ml) caused a significant increase in nitrite production. Nitrites 117-124 interleukin 1 beta Rattus norvegicus 45-62 12237169-8 2002 RESULTS: Incubation of cardiac myocytes with interleukin-1beta (IL-1beta; 10 ng/ml) caused a significant increase in nitrite production. Nitrites 117-124 interleukin 1 beta Rattus norvegicus 64-72 12237169-9 2002 CRP significantly increased the IL-1beta-induced nitrite production in a dose-dependent manner (10-100 microg/ml). Nitrites 49-56 C-reactive protein Rattus norvegicus 0-3 12237169-9 2002 CRP significantly increased the IL-1beta-induced nitrite production in a dose-dependent manner (10-100 microg/ml). Nitrites 49-56 interleukin 1 beta Rattus norvegicus 32-40 12450070-9 2002 In NS aortic rings, the NO inhibitor did not inhibit basal nitrite release but blunted the Ang-II-stimulated nitrite level. Nitrites 109-116 angiogenin Oryctolagus cuniculus 91-94 12450070-10 2002 A significant negative correlation between nitrite release and the ANP vasorelaxant effect on basal tone was dependent on the Ang-II-sensitizing dose. Nitrites 43-50 angiogenin Oryctolagus cuniculus 126-129 12426117-1 2002 The peroxidase-catalyzed nitration of tyrosine derivatives by nitrite and hydrogen peroxide has been studied in detail using the enzymes lactoperoxidase (LPO) from bovine milk and horseradish peroxidase (HRP). Nitrites 62-69 lactoperoxidase Bos taurus 137-152 12426117-1 2002 The peroxidase-catalyzed nitration of tyrosine derivatives by nitrite and hydrogen peroxide has been studied in detail using the enzymes lactoperoxidase (LPO) from bovine milk and horseradish peroxidase (HRP). Nitrites 62-69 lactoperoxidase Bos taurus 154-157 12370118-8 2002 1400 W (50 micromol/l) fully counteracted both the suppression of glucose oxidation rate, (pro)insulin biosynthesis and nitrite accumulation caused by IL-1beta. Nitrites 120-127 interleukin 1 beta Mus musculus 151-159 12237746-8 2002 In mice treated with LPS significantly increased levels of plasma nitrite and serum TNF-alpha were observed, changes inhibited by aminoguanidine [an inhibitor of inducible NO synthase (iNOS)] and pentoxifylline (an inhibitor of tumor necrosis factor-alpha formation), respectively. Nitrites 66-73 nitric oxide synthase 2, inducible Mus musculus 162-183 12237746-8 2002 In mice treated with LPS significantly increased levels of plasma nitrite and serum TNF-alpha were observed, changes inhibited by aminoguanidine [an inhibitor of inducible NO synthase (iNOS)] and pentoxifylline (an inhibitor of tumor necrosis factor-alpha formation), respectively. Nitrites 66-73 nitric oxide synthase 2, inducible Mus musculus 185-189 12230634-6 2002 The decreased insulin response was associated with significant elevation of nitric oxide produced from GSNO and SNAP co-administered with vitamin C, as assessed by plasma nitrate/nitrite levels. Nitrites 179-186 insulin Canis lupus familiaris 14-21 12127413-6 2002 In addition, pre-incubation of macrophages from a transformed chicken macrophage cell line, MQ-NCSU, with 50 microg/ml anti-CD14 and anti-TLR4 antibodies significantly reduced where as pre-incubation with 100 microg/ml completely blocked LPS-mediated iNOS activity as measured by nitrite levels. Nitrites 280-287 CD14 molecule Gallus gallus 124-128 12127413-6 2002 In addition, pre-incubation of macrophages from a transformed chicken macrophage cell line, MQ-NCSU, with 50 microg/ml anti-CD14 and anti-TLR4 antibodies significantly reduced where as pre-incubation with 100 microg/ml completely blocked LPS-mediated iNOS activity as measured by nitrite levels. Nitrites 280-287 toll like receptor 4 Gallus gallus 138-142 12208366-6 2002 Of special interest has been the finding that XOR can catalyze the reduction of nitrates and nitrites to nitric oxide (NO), acting as a source of both NO and peroxynitrite. Nitrites 93-101 xanthine dehydrogenase Homo sapiens 46-49 12351936-12 2002 Nitrite production was greatest over the initial 24 hr of stimulation with iNOS enzyme activity peaking at 12 hr. Nitrites 0-7 nitric oxide synthase 2 Homo sapiens 75-79 12197734-1 2002 Catalytic reduction of nitrite and theoretical prediction of eta(1)-, eta(2)-N(2)O bound intermediates. Nitrites 23-30 secreted phosphoprotein 1 Homo sapiens 61-69 12351936-8 2002 Following stimulation, iNOS induction was monitored via measurement of nitrite production and in vitro iNOS enzyme activity. Nitrites 71-78 nitric oxide synthase 2 Homo sapiens 23-27 12230105-3 2002 When OD (1 mg/ml) was used in combination with 10 U/ml of recombinant interferon-gamma (rIFN-gamma), there was a marked cooperative induction of NO production (36.13+/-7.12 microM) by the Griess method (nitrite). Nitrites 203-210 interferon gamma Rattus norvegicus 88-98 12351936-11 2002 Induction of nitrite production by a cytomix [IFNgamma (100 ng/ml) + TNFalpha (30 ng/ml) + IL-1beta (5 ng/ml)] was differentially enhanced by exposure to supplemental factors including LPS, L-arginine, and BH4. Nitrites 13-20 interferon gamma Homo sapiens 46-54 12351936-11 2002 Induction of nitrite production by a cytomix [IFNgamma (100 ng/ml) + TNFalpha (30 ng/ml) + IL-1beta (5 ng/ml)] was differentially enhanced by exposure to supplemental factors including LPS, L-arginine, and BH4. Nitrites 13-20 tumor necrosis factor Homo sapiens 69-77 12351936-11 2002 Induction of nitrite production by a cytomix [IFNgamma (100 ng/ml) + TNFalpha (30 ng/ml) + IL-1beta (5 ng/ml)] was differentially enhanced by exposure to supplemental factors including LPS, L-arginine, and BH4. Nitrites 13-20 interleukin 1 beta Homo sapiens 91-99 12226143-6 2002 RESULTS: Leptin increased plasma concentrations of NO metabolites (nitrates + nitrites, NO(x)) by 32.5%, 58.0%, and 29.7% at 1, 2, and 4 hours, respectively. Nitrites 78-86 leptin Rattus norvegicus 9-15 12355497-11 2002 Administration of anti-LOX-1 antibody, which blocks LOX-1 activity, suppressed joint swelling (by 33.5%), leukocyte infiltration, and joint nitrite accumulation at 24 hours, as well as cartilage destruction at 7 days, compared with control rats. Nitrites 140-147 oxidized low density lipoprotein receptor 1 Rattus norvegicus 23-28 12358336-9 2002 In iNOS-deficient mice, both iNOS expression and NT formation were completely abolished, and the total amounts of nitrite and nitrate in BAL fluid were significantly decreased. Nitrites 114-121 nitric oxide synthase 2, inducible Mus musculus 3-7 12183564-3 2002 Immunoblotting and nitrite assays revealed that C. burnetii infection of L-929 cells augments expression of iNOS up-regulated in response to gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha). Nitrites 19-26 nitric oxide synthase 2, inducible Mus musculus 108-112 12183564-5 2002 Nitrite production by cytokine-treated cells was significantly inhibited by the iNOS inhibitor S-methylisothiourea (SMT). Nitrites 0-7 nitric oxide synthase 2, inducible Mus musculus 80-84 12198324-6 2002 Angiotensin II (1 microg) released renal nitrites by 485 +/- 178, 470 +/- 150, 185 +/- 45, and 515 +/- 100 nmol/ml/30 s in the kidneys from normotensive, losartan-treated normotensive rats, hypertensive, and losartan-treated hypertensive rats, respectively. Nitrites 41-49 angiotensinogen Rattus norvegicus 0-14 12244435-0 2002 Nitrite accumulation and nitric oxide emission in relation to cellular signaling in nitrite reductase antisense tobacco. Nitrites 0-7 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 84-101 12244435-1 2002 An antisense nitrite reductase (NiR, EC 1.7.7.1) tobacco ( Nicotiana tabacum L.) transformant (clone 271) was used to gain insight into a possible correlation between nitrate reductase (NR, EC 1.6.6.1)-dependent nitrite accumulation and nitric oxide (NO(.)) Nitrites 13-20 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 32-35 12196156-1 2002 The pentahaem enzyme cytochrome c nitrite reductase catalyses the reduction of nitrite to ammonia, a key reaction in the biological nitrogen cycle. Nitrites 34-41 cytochrome c, somatic Homo sapiens 21-33 12200115-3 2002 The removal of RDX was accompanied by the formation and accumulation of nitrite ion (NO(2)(-)), formaldehyde (HCHO), ammonium (NH(4)(+)), and nitrous oxide (N(2)O). Nitrites 72-79 radixin Homo sapiens 15-18 12200115-6 2002 Product stoichiometry showed that each reacted RDX molecule produced one nitrite ion and the product distribution gave a carbon (C) and nitrogen (N) mass balance of 91 and 92%, respectively, supporting the occurrence of a mono-denitration step prior to the ring cleavage and decomposition. Nitrites 73-80 radixin Homo sapiens 47-50 12172843-4 2002 The presence of the high-affinity nitrate transport system I (NRT2;1, NAR2) made cells able to sense the very low concentrations of nitrate present in culture medium with no added nitrate and to express optimally Nii1, Nrt2;1, Nrt2;3, and Nar1 genes involved in nitrate/nitrite assimilation. Nitrites 270-277 uncharacterized protein Chlamydomonas reinhardtii 213-217 12171787-5 2002 Bradykinin (10(-5) mol/L) and acetylcholine (10(-5) mol/L) increased nitrite release by 83+/-13 and 72+/-6 pmol/mg, respectively (P<0.05 versus control). Nitrites 69-76 kininogen 1 Canis lupus familiaris 0-10 12171788-3 2002 METHODS AND RESULTS: After gene transfer, expression of eNOS in cultured cells was detected by increased intracellular cGMP and nitrate/nitrite levels and NO synthase activity. Nitrites 136-143 nitric oxide synthase 3 Rattus norvegicus 56-60 12110981-10 2002 The method was applied, and validated chemometrically, for the determination of nitrite in different types of water (spring, mineral, tap, well, and sea). Nitrites 80-87 nuclear RNA export factor 1 Homo sapiens 134-137 12052727-1 2002 Nitrites and nitrates are widely used reporters of endogenous activity of nitric oxide synthases (NOS), an important group of enzymes producing the gaseous signal molecule nitric oxide (NO). Nitrites 0-8 nitric oxide synthase 2 Homo sapiens 74-96 12069938-6 2002 TNF-alpha caused significant inhibition of ACh- and bradykinin-induced vascular relaxation and nitrite/nitrate production that were more prominent in pregnant than virgin rats. Nitrites 95-102 tumor necrosis factor Rattus norvegicus 0-9 12110440-8 2002 The NO synthesis appeared to be via inducible NO synthase (iNOS) on the basis of the time course and levels of nitrite obtained, although the inhibition of other NOS isoforms by aminoguanidine cannot be excluded. Nitrites 111-118 nitric oxide synthase 2 Homo sapiens 36-57 12093672-5 2002 Levels of nitrite and/or nitrate in the serum were elevated within 2 h after administration of IL-18, reaching a peak at 4 h and then decreasing gradually to the basal level over a 24-h period of time. Nitrites 10-17 interleukin 18 Mus musculus 95-100 12110440-8 2002 The NO synthesis appeared to be via inducible NO synthase (iNOS) on the basis of the time course and levels of nitrite obtained, although the inhibition of other NOS isoforms by aminoguanidine cannot be excluded. Nitrites 111-118 nitric oxide synthase 2 Homo sapiens 59-63 12099927-6 2002 Interestingly, we observed a significant negative correlation between IL-6 and nitrite/nitrate levels in the CSF in the total MS group. Nitrites 79-86 interleukin 6 Homo sapiens 70-74 12127127-9 2002 Plasma and intestinal levels of the nitric oxide products, nitrite/nitrate, were increased in the iNOS +/+ mice fed the TPN solution but not in the chow-fed groups or the iNOS -/- mice receiving TPN solution. Nitrites 59-66 nitric oxide synthase 2, inducible Mus musculus 98-102 12188499-5 2002 The expression levels of iNOS mRNA and the nitrite content in the membranes significantly correlated with those of TNF-alpha and cPLA2 mRNAs, respectively. Nitrites 43-50 tumor necrosis factor Homo sapiens 115-124 12188499-5 2002 The expression levels of iNOS mRNA and the nitrite content in the membranes significantly correlated with those of TNF-alpha and cPLA2 mRNAs, respectively. Nitrites 43-50 phospholipase A2 group IVA Homo sapiens 129-134 12115884-6 2002 Induction of iNOS was confirmed by measurement of nitrate/nitrite production and by immunodetection. Nitrites 58-65 nitric oxide synthase 2 Homo sapiens 13-17 11996950-5 2002 Incubation of cell cultures with interleukin-1beta (IL-1beta) for 24 h caused a significant increase in nitrite accumulation. Nitrites 104-111 interleukin 1 beta Homo sapiens 33-50 12012430-6 2002 The levels of nitrite (NO(2) (-)) and nitrate (NO(3) (-)) in the hippocampus of wild-type mice were increased with time after ischemia-reperfusion, whereas the increase was significantly inhibited in IL-1 knockout mice. Nitrites 14-21 interleukin 1 complex Mus musculus 200-204 11996950-9 2002 Use of specific tyrosine kinase inhibitor herbimycin A, genistein, or PP2 (Src family kinase inhibitor) indicated that tyrosine kinases are required for IL-1beta-stimulated and beta-VLDL-enhanced nitrite accumulation, while specific inhibition of ERK1/2 or p38-MAP kinase had no effects. Nitrites 196-203 neuropeptide Y receptor Y6 (pseudogene) Homo sapiens 70-73 11996950-5 2002 Incubation of cell cultures with interleukin-1beta (IL-1beta) for 24 h caused a significant increase in nitrite accumulation. Nitrites 104-111 interleukin 1 beta Homo sapiens 52-60 11996950-9 2002 Use of specific tyrosine kinase inhibitor herbimycin A, genistein, or PP2 (Src family kinase inhibitor) indicated that tyrosine kinases are required for IL-1beta-stimulated and beta-VLDL-enhanced nitrite accumulation, while specific inhibition of ERK1/2 or p38-MAP kinase had no effects. Nitrites 196-203 interleukin 1 beta Homo sapiens 153-161 11996950-6 2002 Although beta-VLDL alone did not increase nitrite accumulation in unstimulated VSMC, beta-VLDL significantly enhanced nitrite accumulation in IL-1beta-stimulated VSMC in a time- and dose-dependent manner. Nitrites 118-125 interleukin 1 beta Homo sapiens 142-150 11996950-9 2002 Use of specific tyrosine kinase inhibitor herbimycin A, genistein, or PP2 (Src family kinase inhibitor) indicated that tyrosine kinases are required for IL-1beta-stimulated and beta-VLDL-enhanced nitrite accumulation, while specific inhibition of ERK1/2 or p38-MAP kinase had no effects. Nitrites 196-203 mitogen-activated protein kinase 3 Homo sapiens 247-253 11996950-7 2002 beta-VLDL-induced nitrite accumulation in IL-1beta-stimulated VSMC was accompanied by an increase in iNOS protein and mRNA expression. Nitrites 18-25 interleukin 1 beta Homo sapiens 42-50 11996950-9 2002 Use of specific tyrosine kinase inhibitor herbimycin A, genistein, or PP2 (Src family kinase inhibitor) indicated that tyrosine kinases are required for IL-1beta-stimulated and beta-VLDL-enhanced nitrite accumulation, while specific inhibition of ERK1/2 or p38-MAP kinase had no effects. Nitrites 196-203 mitogen-activated protein kinase 1 Homo sapiens 257-260 11877405-3 2002 However, since the discovery that myeloperoxidase (MPO) and eosinophil peroxidase (EPO) can generate nitrotyrosine via oxidation of nitrite (NO(2)(-)), several questions have arisen. Nitrites 132-139 myeloperoxidase Mus musculus 34-49 11996950-10 2002 Our results suggest that beta-VLDL enhances iNOS expression and nitrite accumulation in IL-1beta-stimulated VSMC through tyrosine kinase(s)-dependent mechanisms. Nitrites 64-71 interleukin 1 beta Homo sapiens 88-96 11877405-3 2002 However, since the discovery that myeloperoxidase (MPO) and eosinophil peroxidase (EPO) can generate nitrotyrosine via oxidation of nitrite (NO(2)(-)), several questions have arisen. Nitrites 132-139 myeloperoxidase Mus musculus 51-54 11877405-3 2002 However, since the discovery that myeloperoxidase (MPO) and eosinophil peroxidase (EPO) can generate nitrotyrosine via oxidation of nitrite (NO(2)(-)), several questions have arisen. Nitrites 132-139 eosinophil peroxidase Mus musculus 60-81 11877405-3 2002 However, since the discovery that myeloperoxidase (MPO) and eosinophil peroxidase (EPO) can generate nitrotyrosine via oxidation of nitrite (NO(2)(-)), several questions have arisen. Nitrites 132-139 erythropoietin Mus musculus 83-86 11978125-3 2002 In addition, nitrite was found to bind both Cbl(III) and Cbl(II) and a binding constant of 3.5 x 10(2) M(-1) was measured for (NO(2)-Cbl(II))(1-). Nitrites 13-20 Cbl proto-oncogene Homo sapiens 44-47 11943658-3 2002 Incubation of transplant AMs with SP-A increased intracellular Ca(2+) concentration ([Ca(2+)](i)) by 70% and nitrite and nitrate (NO(x)) production by 45% (from 0.24 +/- 0.02 to 1.3 +/- 0.21 nmol small middle dot 10(6) AMs(-1).h(-1)). Nitrites 109-116 surfactant protein A1 Homo sapiens 34-38 11978125-3 2002 In addition, nitrite was found to bind both Cbl(III) and Cbl(II) and a binding constant of 3.5 x 10(2) M(-1) was measured for (NO(2)-Cbl(II))(1-). Nitrites 13-20 Cbl proto-oncogene Homo sapiens 48-51 11978125-3 2002 In addition, nitrite was found to bind both Cbl(III) and Cbl(II) and a binding constant of 3.5 x 10(2) M(-1) was measured for (NO(2)-Cbl(II))(1-). Nitrites 13-20 Cbl proto-oncogene Homo sapiens 57-60 11978125-3 2002 In addition, nitrite was found to bind both Cbl(III) and Cbl(II) and a binding constant of 3.5 x 10(2) M(-1) was measured for (NO(2)-Cbl(II))(1-). Nitrites 13-20 Cbl proto-oncogene Homo sapiens 57-60 12066846-7 2002 Nitrostyrene treatment of macrophages, stimulated with IFN gamma and LPS, resulted in a dose dependent differential inhibition in IL12, IL6 and nitrite production, even using doses < 0.5 microg/mL. Nitrites 144-151 interferon gamma Homo sapiens 55-64 12066846-7 2002 Nitrostyrene treatment of macrophages, stimulated with IFN gamma and LPS, resulted in a dose dependent differential inhibition in IL12, IL6 and nitrite production, even using doses < 0.5 microg/mL. Nitrites 144-151 interferon regulatory factor 6 Homo sapiens 69-72 12066846-8 2002 Thus ranking of the three, on the basis of the suppressive effect obtained, is IL12 > nitrite > IL6. Nitrites 89-96 interleukin 6 Homo sapiens 102-105 12133319-16 2002 (4) A significant positive correlation was found between the MMP-2 mRNA levels and nitrites/nitrates levels in L-arginine group and asthmatic group (r(s) = 0.65, 0.68, P < 0.05), but there was no significant correlation between the nitrites/nitrates levels and the TIMP-1 mRNA levels in the two groups (r(s) = 0.23, 0.18, P > 0.05). Nitrites 83-91 matrix metallopeptidase 2 Rattus norvegicus 61-66 12021246-9 2002 Our observations provide strong evidence that myeloperoxidase generates reactive nitrogen species in vivo and that it operates in this fashion only when nitrite and nitrate become available. Nitrites 153-160 myeloperoxidase Mus musculus 46-61 12009845-5 2002 The addition of IL-1 beta, TNF-alpha, and IFN-gamma together increased nitrite production: 257.5 +/- 35.8 % and S-nitrosothiol production : 413 +/- 29%, P < 0.001. Nitrites 71-78 interleukin 1 beta Homo sapiens 16-25 12009845-5 2002 The addition of IL-1 beta, TNF-alpha, and IFN-gamma together increased nitrite production: 257.5 +/- 35.8 % and S-nitrosothiol production : 413 +/- 29%, P < 0.001. Nitrites 71-78 tumor necrosis factor Homo sapiens 27-36 12009845-5 2002 The addition of IL-1 beta, TNF-alpha, and IFN-gamma together increased nitrite production: 257.5 +/- 35.8 % and S-nitrosothiol production : 413 +/- 29%, P < 0.001. Nitrites 71-78 interferon gamma Homo sapiens 42-51 12133319-16 2002 (4) A significant positive correlation was found between the MMP-2 mRNA levels and nitrites/nitrates levels in L-arginine group and asthmatic group (r(s) = 0.65, 0.68, P < 0.05), but there was no significant correlation between the nitrites/nitrates levels and the TIMP-1 mRNA levels in the two groups (r(s) = 0.23, 0.18, P > 0.05). Nitrites 235-243 matrix metallopeptidase 2 Rattus norvegicus 61-66 11939777-2 2002 The NapB protein is essential in transferring electrons to the large catalytic subunit NapA, which subsequently reduces nitrate to nitrite. Nitrites 131-138 NSF attachment protein beta Homo sapiens 4-8 18968594-7 2002 Oxygen, trichloroacetic acid (TCA) and nitrite were catalytically reduced by Mb-PAM film electrodes with significant lowering of overpotential. Nitrites 39-46 myoglobin Homo sapiens 77-79 11927648-7 2002 Upon stimulation with antigen, IFN-gamma, or anti-CD8, nitrite production was increased significantly (8.4+/-0.6, 7.6+/-0.9, and 6.6+/-0.9 microM/2x10(5) cells/48 h NO2-, respectively; P<0.01), whereas unstimulated PMC released 2.1 +/- 0.3 microM/2 x 10(5) cells/48 h NO2-. Nitrites 55-62 interferon gamma Rattus norvegicus 31-40 12062366-5 2002 RESULTS: Nitrite accumulation in the myoblast culture supernatant or iNOS protein in the cell pellet was significantly increased after incubation with IL-1beta in combination with gamma-IFN. Nitrites 9-16 interleukin 1 beta Homo sapiens 151-159 12081242-10 2002 We concluded that the decrease in nitrate/nitrite concentration in preovulatory follicles after hCG injection was due mainly to decreased iNOS expression in granulosa cells. Nitrites 42-49 nitric oxide synthase 2 Rattus norvegicus 138-142 11927384-5 2002 ATP levels were reduced by approximately 30% while nitrite production increased twofold from BRIN BD11 cells incubated for 24 h in the presence of Type-1 diabetic patient sera compared with normal human sera. Nitrites 51-58 defensin beta 11 Rattus norvegicus 98-102 12064473-4 2002 The production of nitrite peaked after 48 h of incubation, and this reflected transcriptional activation of the NOS-2 gene and increased expression of the NOS-2 protein. Nitrites 18-25 nitric oxide synthase 2, inducible Mus musculus 112-117 12064473-4 2002 The production of nitrite peaked after 48 h of incubation, and this reflected transcriptional activation of the NOS-2 gene and increased expression of the NOS-2 protein. Nitrites 18-25 nitric oxide synthase 2, inducible Mus musculus 155-160 11960752-1 2002 Myeloperoxidase, in the presence of hydrogen peroxide and nitrite, promotes the lipid peroxidation of low density lipoprotein (LDL); the modified lipoprotein is then capable of being readily endocytosed by macrophages. Nitrites 58-65 myeloperoxidase Homo sapiens 0-15 11954828-7 2002 PARP-/- mice, and their wild-type littermate showed a similar time-dependent increase in plasma nitrite/nitrate and in gut and lung MDA content, as well as the presence of nitrotyrosine in the gut. Nitrites 96-103 poly (ADP-ribose) polymerase family, member 1 Mus musculus 0-4 11911836-2 2002 Sanguiin H-6 inhibited nitrite production, taken as an index for NO, in a concentration-dependent fashion. Nitrites 23-30 H6 family homeobox 1 Homo sapiens 9-12 11887178-9 2002 In addition, Iso as well as IGF-1 significantly increased eNOS activity measured by nitrite production. Nitrites 84-91 insulin-like growth factor 1 Rattus norvegicus 28-33 11814459-5 2002 There was a weak but significant correlation between the nitrite/nitrate and endothelin-1 concentrations in the NP and NTP groups (r(1)=0.46, P<0.05, and r(2)=0.38, P<0.05, respectively) which probably revealed the balance between these vasoactive factors. Nitrites 57-64 endothelin 1 Homo sapiens 77-89 11874235-6 2002 However, SIN-1-induced NO* production, measured by nitrite release to the hOB medium, was not altered by cotreatment with SOD and CAT. Nitrites 51-58 MAPK associated protein 1 Homo sapiens 9-14 11875313-6 2002 IL-1beta increased nitrite formation in a time-dependent manner. Nitrites 19-26 interleukin 1 beta Rattus norvegicus 0-8 11917083-9 2002 The results presented here provide direct in vivo evidence to confirm that NR is involved in the nitrite-dependent NO production in the green alga. Nitrites 97-104 uncharacterized protein Chlamydomonas reinhardtii 75-77 12053462-7 2002 Nitrite levels were significantly decreased both in the ipsi- and contralateral striatum and forebrain cortex of NGF- and FGF-treated animals compared with QA treatment. Nitrites 0-7 nerve growth factor Rattus norvegicus 113-116 11823513-7 2002 Infected IL-12p40(-/-) and IFN-gamma(-/-) mice also mounted anti-Citrobacter serum and gut-associated IgA responses and strongly expressed inducible NO synthase (iNOS) in mucosal tissue, despite diminished serum nitrite/nitrate levels. Nitrites 212-219 interleukin 12b Mus musculus 9-17 11823513-7 2002 Infected IL-12p40(-/-) and IFN-gamma(-/-) mice also mounted anti-Citrobacter serum and gut-associated IgA responses and strongly expressed inducible NO synthase (iNOS) in mucosal tissue, despite diminished serum nitrite/nitrate levels. Nitrites 212-219 interferon gamma Mus musculus 27-36 11869456-0 2002 Angiotensin converting enzyme inhibitor therapy in children with Alport syndrome: effect on urinary albumin, TGF-beta, and nitrite excretion. Nitrites 123-130 angiotensin I converting enzyme Homo sapiens 0-29 11863253-6 2002 RESULTS: A twofold increase in plasma TNF-alpha levels in pregnant rats resulted in a significant increase in arterial pressure (97 +/- 3.6 v 116 +/- 2.1 mm Hg, pregnant versus TNF-alpha pregnant, respectively, P < .05), but no significant change in urinary nitrite/nitrate excretion (22.0 +/- 1.9 v 20.8 +/- 2.5 micromol/24 h, pregnant versus TNF-alpha pregnant, respectively), a measure of whole body NO production. Nitrites 261-268 tumor necrosis factor Rattus norvegicus 38-47 11878390-2 2002 This method is similar to U.S. Environmental Protection Agency method 353.2 and U.S. Geological Survey method 1-2545-90 except that nitrate is reduced to nitrite by soluble nitrate reductase (NaR, EC 1.6.6.1) purified from corn leaves rather than a packed-bed cadmium reactor. Nitrites 154-161 nitrate reductase [NADH] 1 Zea mays 173-190 11862421-9 2002 Moreover, significant nitrite production was detected in the HN12 cell line after treatment with IL-13 toxin for 48--96 h. Taken together, our results suggest that IL-13 toxin-induced cytotoxicity is at least partially mediated by the apoptosis and nitric oxide pathways. Nitrites 22-29 interleukin 13 Homo sapiens 97-102 11792648-8 2002 Basal and ACh-induced nitrite/nitrate production was less in TNF-alpha-infused than in control pregnant rats. Nitrites 22-29 tumor necrosis factor Rattus norvegicus 61-70 11834136-5 2002 The concentrations of nitrites, cGMP and cAMP in the culture medium of HUVECs treated with a mixture of thrombin and adenosine were significantly higher compared with the culture medium of HUVECs treated with thrombin alone. Nitrites 22-30 coagulation factor II, thrombin Homo sapiens 104-112 11862421-9 2002 Moreover, significant nitrite production was detected in the HN12 cell line after treatment with IL-13 toxin for 48--96 h. Taken together, our results suggest that IL-13 toxin-induced cytotoxicity is at least partially mediated by the apoptosis and nitric oxide pathways. Nitrites 22-29 interleukin 13 Homo sapiens 164-169 11751209-5 2002 Ron tk-/- mice succumb to nickel-induced ALI earlier, express larger, early increases in interleukin-6, monocyte chemoattractant protein-1, and macrophage inflammatory protein-2, display greater serum nitrite levels, and exhibit earlier onset of pulmonary pathology and augmented pulmonary tyrosine nitrosylation. Nitrites 201-208 macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Mus musculus 0-3 11849384-3 2002 METHODS: Induction of iNOS was examined by RT-PCR, Western blot, immunohistochemistry and nitrite measurements. Nitrites 90-97 nitric oxide synthase 2 Homo sapiens 22-26 11858480-6 2002 RESULTS: Increased TF and PAI-1 antigen, and PAI-1 activity levels were associated with increasing IL-6 and nitrite + nitrate levels (p <0.05), the development of MOF (p <0.05), and mortality (p <0.05). Nitrites 108-115 coagulation factor III, tissue factor Homo sapiens 19-21 11858480-6 2002 RESULTS: Increased TF and PAI-1 antigen, and PAI-1 activity levels were associated with increasing IL-6 and nitrite + nitrate levels (p <0.05), the development of MOF (p <0.05), and mortality (p <0.05). Nitrites 108-115 serpin family E member 1 Homo sapiens 26-31 11858480-6 2002 RESULTS: Increased TF and PAI-1 antigen, and PAI-1 activity levels were associated with increasing IL-6 and nitrite + nitrate levels (p <0.05), the development of MOF (p <0.05), and mortality (p <0.05). Nitrites 108-115 serpin family E member 1 Homo sapiens 45-50 11755292-9 2002 Growth hormone, but not placebo, greatly improved this response (p = 0.03) and, concomitantly, increased the forearm release of nitrite and cGMP (p < 0.05). Nitrites 128-135 growth hormone 1 Homo sapiens 0-14 11751214-3 2002 Human bronchial epithelial cells stimulated with 50 ng/ml interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma express iNOS mRNA, protein and increased nitrite in the cell culture media, which was inhibited by the selective iNOS inhibitor 1400W. Nitrites 168-175 interferon gamma Homo sapiens 110-126 19008412-5 2009 In support of the beneficial effects of pcDNA3.1-eNOS treatment being because of enhanced eNOS expression and activity, increased eNOS protein levels were documented in aorta, liver, kidney, and heart of fructose-treated rats injected with pcDNA3.1-eNOS, and corresponding elevations in nitrite/nitrate and cGMP concentrations were observed in urine. Nitrites 287-294 nitric oxide synthase 3 Rattus norvegicus 49-53 11812639-3 2002 Nitrites formation was used as an indirect way to assess LPS-mediated activation of nitric oxide synthase (iNOS, type 2). Nitrites 0-8 nitric oxide synthase 2 Rattus norvegicus 107-111 11751214-3 2002 Human bronchial epithelial cells stimulated with 50 ng/ml interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma express iNOS mRNA, protein and increased nitrite in the cell culture media, which was inhibited by the selective iNOS inhibitor 1400W. Nitrites 168-175 interleukin 1 beta Homo sapiens 58-104 12051519-7 2002 Endothelin-1 additions diminished nitrate and nitrite levels in embryos from both control and n-stz diabetic rats, whereas bosentan stimulated nitrate and nitrite generation in those embryos. Nitrites 46-53 endothelin 1 Rattus norvegicus 0-12 11742807-1 2002 In rat aortic smooth muscle cells (RASMC), interferon (IFN)-gamma enhanced nitrite accumulation and type II nitric oxide synthase (iNOS) protein expression induced by interleukin (IL)-1 beta. Nitrites 75-82 interferon gamma Rattus norvegicus 43-65 12097830-6 2002 RESULTS: Ticlopidine enhanced interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner. Nitrites 67-74 interleukin 1 beta Rattus norvegicus 30-47 12097830-6 2002 RESULTS: Ticlopidine enhanced interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner. Nitrites 67-74 interleukin 1 beta Rattus norvegicus 49-57 12097830-9 2002 KT 5720, a selective inhibitor of protein kinase A, but not KT 5823, a selective inhibitor of protein kinase G, abolished the enhancement of IL-1beta-induced nitrite production by ticlopidine. Nitrites 158-165 interleukin 1 beta Rattus norvegicus 141-149 11902126-2 2002 Patients with 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase and dihydropteridine reductase deficiencies exhibited decreased CSF nitrite + nitrate levels compared with healthy control subjects. Nitrites 142-149 6-pyruvoyltetrahydropterin synthase Homo sapiens 14-50 11902126-2 2002 Patients with 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase and dihydropteridine reductase deficiencies exhibited decreased CSF nitrite + nitrate levels compared with healthy control subjects. Nitrites 142-149 sepiapterin reductase Homo sapiens 52-73 11793130-6 2002 Urinary nitrite + nitrate excretion was significantly lower in iNOS KO mice compared to control animals at all time points; in C57 mice, urinary nitrite declined progressively with more prolonged duration of diabetes. Nitrites 8-15 nitric oxide synthase 2, inducible Mus musculus 63-67 11755929-4 2002 Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 5-13 11755929-4 2002 Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs. Nitrites 105-112 tumor necrosis factor Rattus norvegicus 18-27 11862553-1 2002 Nitrite binds reversibly to the ferriheme proteins metmyoglobin and methemoglobin in aqueous buffer solution at a physiological pH of 7.4. Nitrites 0-7 hemoglobin subunit gamma 2 Homo sapiens 68-81 12210732-7 2002 On the other hand, IL-1beta, a Th1 proinflammatory cytokine, dramatically increases nitrite and nitrate levels, as well as inducible nitric oxide synthase (iNOS) transcripts and also upregulates islet ICAM-1 expression as well as circulating ICAM-1 levels. Nitrites 84-91 interleukin 1 beta Mus musculus 19-27 12210732-7 2002 On the other hand, IL-1beta, a Th1 proinflammatory cytokine, dramatically increases nitrite and nitrate levels, as well as inducible nitric oxide synthase (iNOS) transcripts and also upregulates islet ICAM-1 expression as well as circulating ICAM-1 levels. Nitrites 84-91 negative elongation factor complex member C/D, Th1l Mus musculus 31-34 11744809-6 2002 METHODS: NO synthesis by the iNOS pathway was evaluated by nitrite and iNOS mRNA and protein productions. Nitrites 59-66 nitric oxide synthase 2 Rattus norvegicus 29-33 11744809-8 2002 RESULTS: High 30 mM glucose concentration led to significant increases in nitrite production of rat mesangial cells upon stimulation with lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma) compared with control 5.6 mM glucose concentration. Nitrites 74-81 interferon gamma Rattus norvegicus 168-184 11744809-8 2002 RESULTS: High 30 mM glucose concentration led to significant increases in nitrite production of rat mesangial cells upon stimulation with lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma) compared with control 5.6 mM glucose concentration. Nitrites 74-81 interferon gamma Rattus norvegicus 186-195 11899430-8 2001 Furthermore, we demonstrated that exogenous TNF-alpha, at a dose range of 1.9-50 ng per ml, also restored the nitrite response to LPS in the presence of adrenaline. Nitrites 110-117 tumor necrosis factor Mus musculus 44-53 11795978-4 2002 Nitrite concentrations in conditioned media of similarly treated cells were used to quantify iNOS activity. Nitrites 0-7 nitric oxide synthase 2 Equus caballus 93-97 12448468-3 2002 This paper presents the results of studies on determining half saturation constants for nitrate, KNO3, and nitrite, KNO2, in raw wastewater. Nitrites 107-114 ADAM metallopeptidase with thrombospondin type 1 motif 18 Homo sapiens 116-120 12579894-8 2002 Simultaneously, the CuZn-SOD activities in rat liver were determined by nitrite method. Nitrites 72-79 superoxide dismutase 1 Rattus norvegicus 20-28 11577085-11 2001 Heparan sulfate chains of glypican-1 were either cleaved with heparanase at sites embracing the highly modified regions or with nitrite at N-unsubstituted glucosamine residues. Nitrites 128-135 glypican 1 Homo sapiens 26-36 11903618-3 2001 In this study, we found that GM-CSF stimulates the expression of the inducible isoform of nitric oxide synthase (iNOS) in a fetal-skin-derived dendritic cell line (FSDC) and, consequently, increases the nitrite production from 11.9 +/- 3.2 micromol/L (basal level) to 26.9 +/- 4.2 micromol/L. Nitrites 203-210 colony stimulating factor 2 Homo sapiens 29-35 11903618-3 2001 In this study, we found that GM-CSF stimulates the expression of the inducible isoform of nitric oxide synthase (iNOS) in a fetal-skin-derived dendritic cell line (FSDC) and, consequently, increases the nitrite production from 11.9 +/- 3.2 micromol/L (basal level) to 26.9 +/- 4.2 micromol/L. Nitrites 203-210 nitric oxide synthase 2 Homo sapiens 113-117 11903618-4 2001 Pyrrolidinedithiocarbamate (PDTC) inhibits nitrite production, with a half maximal inhibitory concentration (IC50) of 19.3 micromol/L and the iNOS protein expression in FSDC. Nitrites 43-50 nitric oxide synthase 2 Homo sapiens 142-146 11743809-1 2001 GGN-MRP is an extract from the Maillard reaction products of nitrite with glucose and glycine in the Maillard browning system. Nitrites 61-68 gametogenetin Mus musculus 0-3 11811525-8 2001 The generation of nitrite (NO2-) and nitrate (NO3-) by the NaN3/catalase/H2O2 system was maximal at pH 5.0. Nitrites 18-25 catalase Homo sapiens 64-72 11743809-1 2001 GGN-MRP is an extract from the Maillard reaction products of nitrite with glucose and glycine in the Maillard browning system. Nitrites 61-68 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 4-7 11698492-2 2001 Production of NO (as nitrite) by bronchoalveolar lavage cells of IL-10 knockout ((-/-)) mice was assessed after ovalbumin sensitization and airway challenge (S/C) and was compared with the IL-10-sufficient, wild-type (WT) C57Bl6. Nitrites 21-28 interleukin 10 Mus musculus 65-70 11700425-6 2001 In addition, we found a significant correlation between nitrate/nitrite levels and TNF-R1 (r =.70; p =.0001) or TNF-R2 (r =.62; p =.0013), respectively. Nitrites 64-71 TNF receptor superfamily member 1A Homo sapiens 83-89 11700425-6 2001 In addition, we found a significant correlation between nitrate/nitrite levels and TNF-R1 (r =.70; p =.0001) or TNF-R2 (r =.62; p =.0013), respectively. Nitrites 64-71 TNF receptor superfamily member 1B Homo sapiens 112-118 11748259-1 2001 Nitrotyrosine formation is a hallmark of vascular inflammation, with polymorphonuclear neutrophil-derived (PMN-derived) and monocyte-derived myeloperoxidase (MPO) being shown to catalyze this posttranslational protein modification via oxidation of nitrite (NO(2)(-)) to nitrogen dioxide (NO(2)(*)). Nitrites 248-255 myeloperoxidase Mus musculus 141-156 11748259-1 2001 Nitrotyrosine formation is a hallmark of vascular inflammation, with polymorphonuclear neutrophil-derived (PMN-derived) and monocyte-derived myeloperoxidase (MPO) being shown to catalyze this posttranslational protein modification via oxidation of nitrite (NO(2)(-)) to nitrogen dioxide (NO(2)(*)). Nitrites 248-255 myeloperoxidase Mus musculus 158-161 11730359-9 2001 Plasma and urine nitrite/nitrate levels were significantly lower in l-NAME-treated Thy-1 rats compared to nontreated Thy-1 rats. Nitrites 17-24 Thy-1 cell surface antigen Rattus norvegicus 83-88 11729502-6 2001 RESULTS: Lovastatin (10(-5) mol/L) significantly increased interleukin-1 beta (IL-1 beta, 10 ng/mL)-induced nitrite accumulation in a time (0-24 hours)-dependent manner. Nitrites 108-115 interleukin 1 beta Rattus norvegicus 59-77 11729502-6 2001 RESULTS: Lovastatin (10(-5) mol/L) significantly increased interleukin-1 beta (IL-1 beta, 10 ng/mL)-induced nitrite accumulation in a time (0-24 hours)-dependent manner. Nitrites 108-115 interleukin 1 beta Rattus norvegicus 79-88 11729502-8 2001 Furthermore, inhibition of Rho by C3 exoenzyme mimicked the increase in IL-1 beta-induced nitrite accumulation induced by lovastatin in the vascular smooth muscle cells. Nitrites 90-97 interleukin 1 beta Rattus norvegicus 72-81 11606324-4 2001 We report both the concentration-dependent inhibitory effect of CRH upon cytokine-stimulated nitrite release by H5V murine endothelioma cells, and its stimulatory one in HUVEC cells. Nitrites 93-100 corticotropin releasing hormone Mus musculus 64-67 11687295-1 2001 Incubation of human hemoglobin with nitrite and hydrogen peroxide was found to induce autonitration and nitration of another protein (bovine serum albumin), as demonstrated by detection of nitrotyrosine residues in Western blots of separated membrane proteins. Nitrites 36-43 albumin Homo sapiens 141-154 11566406-9 2001 Based on the actual amount of dinitrotoluene degradation, nitrite release, NaOH consumption, and oxygen uptake were close to the theoretical stoichiometric coefficients of complete DNT mineralization. Nitrites 58-65 5', 3'-nucleotidase, cytosolic Homo sapiens 181-184 11693258-4 2001 The AGEs-stimulated nitrite production from C6 glioma cells was inhibited by actinomycin D, cyclohexamide, and the NO synthase inhibitor, Nomega-nitro-L-arginine methyl ester (L-NAME), suggesting that the increase of AGEs-induced nitrite release is due to iNOS up-regulation. Nitrites 20-27 nitric oxide synthase 2 Homo sapiens 256-260 11693258-7 2001 The tyrosine kinase inhibitor (genistein and tyrphostin), the Ras-farnesyl transferase inhibitor (FPT inhibitor-II), or the p38 MAPK inhibitor (SB203580) suppressed AGEs-induced iNOS expression and nitrite release from C6 glioma cells. Nitrites 198-205 mitogen-activated protein kinase 14 Homo sapiens 124-127 11693258-7 2001 The tyrosine kinase inhibitor (genistein and tyrphostin), the Ras-farnesyl transferase inhibitor (FPT inhibitor-II), or the p38 MAPK inhibitor (SB203580) suppressed AGEs-induced iNOS expression and nitrite release from C6 glioma cells. Nitrites 198-205 nitric oxide synthase 2 Homo sapiens 178-182 11606324-12 2001 In fact, anti-Svg-30 inhibited CRH-induced increase of nitrite release and iNOS expression in HUVEC cells. Nitrites 55-62 corticotropin releasing hormone Mus musculus 31-34 11606324-10 2001 CRH increased medium nitrites and iNOS protein expression in H5V cells pretreated with the selective CRH-R1 antagonist CP 154,526. Nitrites 21-29 corticotropin releasing hormone Mus musculus 0-3 11600573-4 2001 Compared with control islets, cells preincubated for 12 or 72 h with proinflammatory and Th1 cytokines showed a significant decrease of glucose-stimulated insulin secretion and a significant increase of nitrites production. Nitrites 203-211 negative elongation factor complex member C/D Homo sapiens 89-92 11534936-8 2001 RESULTS: In the acute phase of colitis, intracolonic nitrite/nitrate levels were significantly higher in the 100 and 500 mg supplemented L-Arg groups than in D-Arg group. Nitrites 53-60 Rho guanine nucleotide exchange factor 12 Rattus norvegicus 137-142 11583718-12 2001 The increase in the serum level of nitrite/nitrate after 3 months of estrogen therapy showed a significant inverse correlation (r=0.52, P<0.01) with the reduction in the plasma level of ACE activity. Nitrites 35-42 angiotensin I converting enzyme Homo sapiens 189-192 11697546-3 2001 In mouse peritoneal macrophages stimulated with lipopolysaccharide, HIP-4 and HIP-5 inhibited nitrite production without affecting prostaglandin E2 (PGE2) accumulation. Nitrites 94-101 cystathionine beta-synthase Mus musculus 68-73 11716172-9 2001 Furthermore, it is shown that nitrite release from Nomega-hydroxy-L-arginine by alveolar macrophages is nitric oxide synthase independent. Nitrites 30-37 nitric oxide synthase 2 Homo sapiens 104-125 11552025-2 2001 The levels of nitrite + nitrate (NOx) in CSF were fourfold higher in patients with PPMS than in controls (p < 0.001), whereas the concentrations in plasma were similar. Nitrites 14-21 colony stimulating factor 2 Homo sapiens 41-44 11642005-3 2001 TNF alpha was measured by cytotoxicity on L-929 cells and nitrite by the Griess reaction, after reduction of all nitrates to nitrites by nitrate reductase, 1 h after LPS injection (0.5 mg/kg i.p.) Nitrites 58-65 tumor necrosis factor Mus musculus 0-9 11513730-7 2001 Inorganic nitrate, like nitrite, was shown to be reduced at the molybdenum site of XOR. Nitrites 24-31 xanthine dehydrogenase Homo sapiens 83-86 11642005-3 2001 TNF alpha was measured by cytotoxicity on L-929 cells and nitrite by the Griess reaction, after reduction of all nitrates to nitrites by nitrate reductase, 1 h after LPS injection (0.5 mg/kg i.p.) Nitrites 125-133 tumor necrosis factor Mus musculus 0-9 11697130-2 2001 Combined treatment of lipopolysaccharide (LPS, 1 microgram/ml) and tumor necrosis factor-alpha (TNF-alpha, 50 ng/ml) synergistically enhanced (23-folds) nitrite production from KNRK cells. Nitrites 153-160 tumor necrosis factor Rattus norvegicus 67-94 11564662-6 2001 The in vivo intravenous administration of aODNs to iNOS, 24 and 12 h before murine tumour necrosis factor alpha (mTNFalpha) challenge, significantly reduced the nitrite levels induced by the mTNFalpha challenge. Nitrites 161-168 nitric oxide synthase 2, inducible Mus musculus 51-55 11536169-6 2001 PD98059, a selective MEK inhibitor, inhibited sPLA(2)-induced nitrite production and iNOS expression as well as ERK phosphorylation. Nitrites 62-69 mitogen-activated protein kinase kinase 7 Homo sapiens 21-24 11536169-6 2001 PD98059, a selective MEK inhibitor, inhibited sPLA(2)-induced nitrite production and iNOS expression as well as ERK phosphorylation. Nitrites 62-69 phospholipase A2 group IIA Homo sapiens 46-53 11536169-11 2001 Furthermore, the NF-kappaB inhibitor PDTC suppressed sPLA(2)-induced nitrite production and iNOS expression as well as IkappaBalpha degradation. Nitrites 69-76 phospholipase A2 group IIA Homo sapiens 53-60 11697130-2 2001 Combined treatment of lipopolysaccharide (LPS, 1 microgram/ml) and tumor necrosis factor-alpha (TNF-alpha, 50 ng/ml) synergistically enhanced (23-folds) nitrite production from KNRK cells. Nitrites 153-160 tumor necrosis factor Rattus norvegicus 96-105 11521163-2 2001 Treatment of cultured RASMC with LPS and IFN-gamma resulted in an increase of nitrite, tumour necrosis factor (TNF-alpha) production and induction of iNOS mRNA. Nitrites 78-85 interferon gamma Mus musculus 41-50 11535790-13 2001 Examination of the genome of the related bacterium R. sphaeroides 2.4.1 revealed that it encodes ppaZ but not nirV and evidence is presented suggesting that a common ancestor of 2.4.3 and 2.4.1 had both nitrite and nitric oxide reductase activity but as the strains diverged 2.4.1 lost nirK and nirV, making it incapable of nitrite reduction. Nitrites 203-210 pseudoazurin Rhodobacter sphaeroides 2.4.1 97-101 11566950-10 2001 In addition, Ang II increased the systemic and renal venous levels of isoprostanes, TBARS, and ET and caused a transient decrease in urinary nitrites (that returned to control levels by day 9). Nitrites 141-149 angiotensinogen Rattus norvegicus 13-19 11488590-4 2001 We demonstrate the novel electronitration (electrooxidation in the presence of nitrite) of a specific tyrosine residue in horse heart myoglobin and also in apomyoglobin. Nitrites 79-86 myoglobin Equus caballus 134-143 11521757-10 2001 The inhibition of neutrophil adherence to epithelial cells with ICAM-1 monoclonal antibody or a semipermeable membrane upregulated nitrite production. Nitrites 131-138 intercellular adhesion molecule 1 Homo sapiens 64-70 11479842-7 2001 The low levels of LMVEC iNOS expression are associated with a 4-fold lower nitrite and nitrate production. Nitrites 75-82 nitric oxide synthase 2 Homo sapiens 24-28 11457725-7 2001 Stable overexpression of Rac2 in RAW 264.7 cells augmented LPS-induced nitrite generation (~60%) and NOS2 activity (~45%) without measurably affecting NOS2 protein abundance and led to a redistribution of NOS2 to a high-speed Triton X-100-insoluble fraction. Nitrites 71-78 Rac family small GTPase 2 Mus musculus 25-29 11515815-5 2001 Nitrite, produced at high concentrations from NO during inflammation, can react with neutrophil myeloperoxidase-derived hypochlorous acid (HOCl) to form the active oxidant nitryl chloride, a species capable of nitrating tyrosine and tyrosyl residues on proteins. Nitrites 0-7 myeloperoxidase Homo sapiens 96-111 11454939-2 2001 Maximal induced activity, measured by the accumulation of nitrite in culture medium, occurred following treatment with lipopolysaccharide and interferon-gamma. Nitrites 58-65 interferon gamma Rattus norvegicus 142-158 11454939-9 2001 Promoter activity in stable transfected C6 cells was inhibited by ethanol exposure with a similar concentration dependence as observed for inhibition of nitrite production, indicating that iNOS inhibition by ethanol is transcriptional. Nitrites 153-160 nitric oxide synthase 2 Rattus norvegicus 189-193 11520904-2 2001 After 24 h of lipopolysaccharide (LPS) (1 microg/mL) and interferon-gamma (IFN-gamma) (300 U/mL) stimulation, a significant increase in NO production, evaluated as nitrite, was observed in the culture medium. Nitrites 164-171 interferon gamma Rattus norvegicus 75-84 11520904-5 2001 The cannabinoid CB1 receptor antagonist, SR141716A (0.1-100 nM), but not the cannabinoid CB2 receptor antagonist, SR144528 (0.1-100 nM), reduced in a dose-related manner WIN 55,212-2-and cannabinol-induced inhibition of nitrite production. Nitrites 220-227 cannabinoid receptor 1 Rattus norvegicus 16-19 11444504-5 2001 The lipophilic statins fluvastatin and lovastatin significantly increased interleukin-1beta-induced nitrite production by cardiac myocytes, whereas hydrophilic pravastatin did not. Nitrites 100-107 interleukin 1 beta Rattus norvegicus 74-91 11455018-8 2001 CYP2J2 transfection attenuated the HR-induced increase in 8-iso-prostaglandin F(2alpha) (p < 0.05) and decreased the amount of extracellular superoxide detected by cytochrome c reduction under normoxic conditions (p < 0.05) but did not significantly affect HR-induced decreases in eNOS expression, L-arginine uptake and conversion, and nitrite production. Nitrites 342-349 cytochrome P450 2J2 Bos taurus 0-6 11474215-6 2001 TNF-alpha increased nitrite release to the incubation medium. Nitrites 20-27 tumor necrosis factor Rattus norvegicus 0-9 11444837-4 2001 We found that myoglobin catalyzed the oxidation of nitrite and promoted the nitration of tyrosine. Nitrites 51-58 myoglobin Homo sapiens 14-23 11444837-5 2001 Both nitrite oxidation and tyrosine nitration were H(2)O(2)-dependent and required the formation of ferryl (Fe(+4)) myoglobin. Nitrites 5-12 myoglobin Homo sapiens 116-125 11454666-5 2001 In contrast, the 5-lipoxygenase (5-LO) inhibitor ZM 230,487 significantly decreased HO-1, iNOS and nitrite, which were not affected by zileuton. Nitrites 99-106 arachidonate 5-lipoxygenase Homo sapiens 17-31 11432840-8 2001 In addition, iNOS expression and nitrite release were dramatically reduced in the parp-1(-/-)p53(-/-) mice compared with parp-1(+/+)p53(-/-) mice. Nitrites 33-40 poly (ADP-ribose) polymerase family, member 1 Mus musculus 82-88 11432840-8 2001 In addition, iNOS expression and nitrite release were dramatically reduced in the parp-1(-/-)p53(-/-) mice compared with parp-1(+/+)p53(-/-) mice. Nitrites 33-40 transformation related protein 53, pseudogene Mus musculus 93-96 11690564-6 2001 This pathway depends on the presence of nitrite and is still effective when the two conventional signaling pathways are blocked by superoxide dismutase (SOD). Nitrites 40-47 superoxide dismutase 1 Homo sapiens 131-151 11690564-6 2001 This pathway depends on the presence of nitrite and is still effective when the two conventional signaling pathways are blocked by superoxide dismutase (SOD). Nitrites 40-47 superoxide dismutase 1 Homo sapiens 153-156 11690564-7 2001 Nitrite-dependent apoptosis induction is neither blocked by SOD nor by the hydroxyl radical scavenger terephthalate, but it is inhibited by the peroxidase inhibitor aminobenzoyl hydrazide and by the hypochlorous acid (HOCl) scavenger taurine. Nitrites 0-7 superoxide dismutase 1 Homo sapiens 60-63 11444504-6 2001 Increased nitrite production by fluvastatin was accompanied by increased iNOS mRNA and protein accumulation. Nitrites 10-17 nitric oxide synthase 2 Rattus norvegicus 73-77 11444504-9 2001 Furthermore, both Rho inhibitor C3 exoenzyme and Rho kinase inhibitor Y-27632 significantly increased interleukin-1beta-induced nitrite accumulation in cardiac myocytes. Nitrites 128-135 interleukin 1 beta Rattus norvegicus 102-119 11476184-4 2001 Incubation of RAW264.7 cells with CPT (0.1 to 10 microM) inhibited the LPS/IFN-gamma-induced nitrite accumulation in a concentration-dependent manner with an IC50 value of 0.59+/-0.07 microM. Nitrites 93-100 toll-like receptor 4 Mus musculus 71-84 11442316-2 2001 A severe inflammatory response characterized by peritoneal exudation, high peritoneal levels of nitrate/nitrite, and leukocyte infiltration into peritoneal exudate was induced by zymosan administration in iNOS +/+ mice. Nitrites 104-111 nitric oxide synthase 2, inducible Mus musculus 205-209 11442316-5 2001 Peritoneal administration of zymosan in the iNOS +/+ mice induced also a significant increase in the plasma levels of nitrite/nitrate and in the levels of peroxynitrite at 18 h after zymosan challenge. Nitrites 118-125 nitric oxide synthase 2, inducible Mus musculus 44-48 11384769-6 2001 Furthermore, the administration of apelin-12 (10 nmol/kg) in rats produced a transitory elevation of the plasma nitrite/nitrate concentration from a basal level of 21.4+/-1.6 to 27.0+/-1.5 microM. Nitrites 112-119 apelin Rattus norvegicus 35-41 11375254-6 2001 However, AMT present during culture additionally to LPS, suppressed LPS-induced nitrite accumulation and LPS-stimulated [3H]-L-arginine uptake in the same concentration-dependent manner. Nitrites 80-87 aminomethyltransferase Rattus norvegicus 9-12 11407704-8 2001 RESULTS: In iNOS+/+ animals with AIA, the plasma concentration of nitrite/nitrate was increased 3-fold and iNOS expression was detected in cells of the joint. Nitrites 66-73 nitric oxide synthase 2, inducible Mus musculus 12-16 11445506-4 2001 In addition, dipstick measurements were made of nitrates and nitrites in tap water for the subset of women living in the same home they had lived in during their pregnancies. Nitrites 61-69 nuclear RNA export factor 1 Homo sapiens 73-76 11389723-0 2001 Mechanism of nitrite-stimulated catalysis by lactoperoxidase. Nitrites 13-20 lactoperoxidase Homo sapiens 45-60 11389723-1 2001 The reactions of lactoperoxidase (LPO) intermediates compound I, compound II and compound III, with nitrite (NO2(-)) were investigated. Nitrites 100-107 lactoperoxidase Homo sapiens 17-32 11389723-1 2001 The reactions of lactoperoxidase (LPO) intermediates compound I, compound II and compound III, with nitrite (NO2(-)) were investigated. Nitrites 100-107 lactoperoxidase Homo sapiens 34-37 11379045-5 2001 We confirm NOS activation because IFN gamma stimulates nitrite production and enzyme activity in SMG. Nitrites 55-62 interferon gamma Mus musculus 34-43 11402201-1 2001 Transgenic plants of Arabidopsis bearing the spinach (Spinacia oleracea) nitrite reductase (NiR, EC 1.7.7.1) gene that catalyzes the six-electron reduction of nitrite to ammonium in the second step of the nitrate assimilation pathway were produced by use of the cauliflower mosaic virus 35S promoter and nopaline synthase terminator. Nitrites 73-80 nitrite reductase 1 Arabidopsis thaliana 92-95 11523538-6 2001 Treatment of microglial cultures with IL-5 increased nitrite levels, while GM-CSF treatment had no effect. Nitrites 53-60 interleukin 5 Homo sapiens 38-42 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Nitrites 166-173 interleukin 1 beta Rattus norvegicus 15-32 11334875-4 2001 Lipopolysaccharide, the active component of endotoxin, significantly induced the expression of inducible nitric oxide synthase and cyclooxygenase-2, leading to the accumulation of nitrite and prostaglandin E(2), respectively. Nitrites 180-187 prostaglandin-endoperoxide synthase 2 Mus musculus 131-147 11343416-8 2001 Activation of the NOS2 pathway was estimated by measurement of mRNA (Northern blot) and protein (Western blot) expression, enzyme activity by conversion of [(3)H]L -arginine to [(3)H]L -citrulline, and nitrite accumulation. Nitrites 202-209 nitric oxide synthase 2 Rattus norvegicus 18-22 11247772-4 2001 iNOS mRNA levels, determined by RT-PCR, and production of nitrite, a stable oxidation product of NO, were markedly elevated in SMC overexpressing IL-1 alpha precursor, and modestly elevated in SMC overexpressing mature IL-1 alpha, relative to SMC transfected with vector alone. Nitrites 58-65 interleukin 1 alpha Rattus norvegicus 146-156 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Nitrites 166-173 interleukin 1 beta Rattus norvegicus 34-42 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Nitrites 166-173 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 52-57 11287034-9 2001 RESULT(S): Administration of IL-1 beta increased nitrite and PGE(2) levels over that observed in the control group after culture of ovarian dispersates for 24 and 48 hours. Nitrites 49-56 interleukin 1 beta Rattus norvegicus 29-38 11399523-10 2001 Inhibition of p38 activity prevented IL-1 beta-induced nitrite production in the presence of D-glucose. Nitrites 55-62 mitogen activated protein kinase 14 Rattus norvegicus 14-17 11399523-10 2001 Inhibition of p38 activity prevented IL-1 beta-induced nitrite production in the presence of D-glucose. Nitrites 55-62 interleukin 1 beta Rattus norvegicus 37-46 11372197-5 2001 Comparisons to hydroxylamine oxidoreductase, the electron donor to cyt c554, and cytochrome c nitrite reductase, an enzyme involved in nitrite ammonification, reveal substantial structural similarity in the polypeptide chain surrounding the heme core environment. Nitrites 94-101 cytochrome c, somatic Homo sapiens 81-93 11275480-5 2001 In the presence of superoxide dismutase (SOD), which also converts NO(-) to *NO, nitrite accumulation was almost doubled and no oxidation of NADPH was observed. Nitrites 81-88 superoxide dismutase 1 Homo sapiens 19-39 11275480-5 2001 In the presence of superoxide dismutase (SOD), which also converts NO(-) to *NO, nitrite accumulation was almost doubled and no oxidation of NADPH was observed. Nitrites 81-88 superoxide dismutase 1 Homo sapiens 41-44 11287034-10 2001 Aspirin dose dependently reduced the IL-1 beta-stimulated increase in nitrite production from ovarian dispersates after culture for 24 and 48 hours. Nitrites 70-77 interleukin 1 beta Rattus norvegicus 37-46 11324986-5 2001 Once induced, iNOS will produce large amounts of NO for long periods of time, so that NO is converted into NO2, nitrite, peroxynitrite and free radicals to induce pathophysiological actions, such as optic nerve degeneration and posterior retinal degeneration lesion, which lead to glaucoma, retinopathy, age-related macular degeneration (AMD), myopia, cataracts and uveitis. Nitrites 112-119 nitric oxide synthase 2 Homo sapiens 14-18 11254342-6 2001 Mb could act as an enzyme-like catalyst in DHP-PDDA films as demonstrated by catalytic reduction of trichloroacetic acid, nitrite, and oxygen with a decrease in the electrode potentials required. Nitrites 122-129 myoglobin Homo sapiens 0-2 11292369-4 2001 Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine. Nitrites 48-55 toll-like receptor 4 Mus musculus 15-18 11294465-4 2001 Incubation with local anesthetics alone did not induce nitrite accumulation; however, the nitrite production induced by stimulation with bacterial endotoxin lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) was increased in a dose-dependent manner by bupivacaine (maximal 3-fold at 360 microM), tetracaine (maximal 7-fold at 360 microM), and lidocaine at higher doses (5-fold increase at 3.3 mM). Nitrites 90-97 interferon gamma Rattus norvegicus 186-202 11294465-4 2001 Incubation with local anesthetics alone did not induce nitrite accumulation; however, the nitrite production induced by stimulation with bacterial endotoxin lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) was increased in a dose-dependent manner by bupivacaine (maximal 3-fold at 360 microM), tetracaine (maximal 7-fold at 360 microM), and lidocaine at higher doses (5-fold increase at 3.3 mM). Nitrites 90-97 interferon gamma Rattus norvegicus 204-213 11294465-8 2001 Increased nitrite production was accompanied by increased NOS2 catalytic activity, steady state mRNA levels, and promoter activation. Nitrites 10-17 nitric oxide synthase 2 Rattus norvegicus 58-62 11259452-7 2001 However, BRE expression was downregulated in human adrenal adenoma and pheochromocytoma, whereas its expression was enhanced in abnormal adrenal tissues of rats chronically treated with nitrate or nitrite. Nitrites 197-204 BRISC and BRCA1 A complex member 2 Homo sapiens 9-12 11292369-4 2001 Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine. Nitrites 149-156 toll-like receptor 4 Mus musculus 123-126 11292369-4 2001 Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine. Nitrites 149-156 toll-like receptor 4 Mus musculus 123-126 11288757-11 2001 Serum total nitrite correlated (Pearson product moment) with percentage of neutrophils in BALF (R = 0.650, P < 0.0001), MPO (R = 0.431, P = 0.0055), change in FEV1 from baseline (deltaFEV1) (R = -0348, P = 0.0298), and days after transplantation (R = 0.345, P = 0.0294). Nitrites 12-19 myeloperoxidase Homo sapiens 123-126 11346959-4 2001 At the pH optimum of pH 6.0, nitrite was reduced to NO with reduced cytochrome c as electron donor at a rate comparable to the nitrate-reducing activity of root-specific succinate-dependent PM-bound nitrate reductase (PM-NR). Nitrites 29-36 cytochrome c, somatic Homo sapiens 68-80 11240902-6 2001 Nitrite production in culture supernatants was due to induction of isoform NOS-2 because both NG monomethyl L-arginine (100 microM) and dexamethasone (20 microM) inhibited, by 60 and 50%, respectively, nitrite accumulation in culture supernatants. Nitrites 0-7 nitric oxide synthase 2, inducible Mus musculus 75-80 11240902-6 2001 Nitrite production in culture supernatants was due to induction of isoform NOS-2 because both NG monomethyl L-arginine (100 microM) and dexamethasone (20 microM) inhibited, by 60 and 50%, respectively, nitrite accumulation in culture supernatants. Nitrites 202-209 nitric oxide synthase 2, inducible Mus musculus 75-80 11326829-9 2001 The level of iNOS immunoreactivity on PBM was highly correlated with nitrite generation both in all the subjects studied and in TB patients alone. Nitrites 69-76 nitric oxide synthase 2 Homo sapiens 13-17 11326829-10 2001 Spontaneous TNF-alpha production showed a stronger correlation with nitrite production than with IL-1 beta. Nitrites 68-75 tumor necrosis factor Homo sapiens 12-21 11054430-3 2001 Furthermore, hypochlorous acid (HOCl), the major strong oxidant generated by MPO in the presence of physiological concentrations of chloride ions, can also react with nitrite, forming the reactive intermediate nitryl chloride. Nitrites 167-174 myeloperoxidase Homo sapiens 77-80 11179135-10 2001 The increase in nitrite levels was supported by immunocytochemistry and Western blot analysis for iNOS protein in A549 cells, indicating activation of iNOS in response to RSV infection. Nitrites 16-23 nitric oxide synthase 2 Homo sapiens 98-102 11179135-10 2001 The increase in nitrite levels was supported by immunocytochemistry and Western blot analysis for iNOS protein in A549 cells, indicating activation of iNOS in response to RSV infection. Nitrites 16-23 nitric oxide synthase 2 Homo sapiens 151-155 11230326-8 2001 Ang II increased SBP (from 133+/-10 to 158+/-8 mm Hg), plasma Ang II (179+/-77 pg/mL), and isoprostanes (156+/-19 pg/mL) without altering ET levels (38+/-5 pg/mL) or urinary nitrites (1.8+/-0.5 microgram/d). Nitrites 174-182 angiotensinogen Rattus norvegicus 0-6 11230326-9 2001 Losartan prevented Ang II-induced increases in SBP and isoprostanes (SBP went from 137+/-5 to 120+/-4 mm Hg; isoprostanes were 115+/-15 pg/mL) while increasing urinary nitrite levels (5.2+/-1.1 microgram/d). Nitrites 168-175 angiotensinogen Rattus norvegicus 19-25 11289303-2 2001 For assimilation of nitrate (and nitrite) there are two types of uptake system known: ABC transporters that are driven by ATP hydrolysis, and secondary transporters reliant on a proton motive force. Nitrites 33-40 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 86-89 11419907-7 2001 J774A.1 cells cultured in RPMI exhibit a 5-fold increase in nitrites in culture supernatants after LPS stimulation whereas those in DMEM/F12 do not. Nitrites 60-68 toll-like receptor 4 Mus musculus 99-102 11209611-3 2001 Spontaneous decomposition of ONOOH to NO3- in 0.15 M phosphate, pH 4.5, gave delta V++ = 6.0 +/- 0.7 and 14 +/- 1.0 cm3 mol-1 in the presence of 53 microM and 5 mM nitrite ion, respectively. Nitrites 164-171 NBL1, DAN family BMP antagonist Homo sapiens 38-41 11054430-0 2001 The nitric oxide congener nitrite inhibits myeloperoxidase/H2O2/ Cl- -mediated modification of low density lipoprotein. Nitrites 26-33 myeloperoxidase Homo sapiens 43-58 11054430-2 2001 Recent studies have shown that myeloperoxidase (MPO), an abundant heme protein released by activated leukocytes, can oxidize nitrite (NO(2-)) to a radical species, most likely nitrogen dioxide. Nitrites 125-132 myeloperoxidase Homo sapiens 31-46 11054430-2 2001 Recent studies have shown that myeloperoxidase (MPO), an abundant heme protein released by activated leukocytes, can oxidize nitrite (NO(2-)) to a radical species, most likely nitrogen dioxide. Nitrites 125-132 myeloperoxidase Homo sapiens 48-51 11054430-5 2001 Interestingly, nitrite concentrations as low as 12.5 and 25 microm significantly decreased MPO/H2O2)/Cl- -induced modification of apoB lysine residues, formation of N-chloramines, and increases in the relative electrophoretic mobility of LDL. Nitrites 15-22 myeloperoxidase Homo sapiens 91-94 11054430-7 2001 Furthermore, experiments using ascorbate (12.5-200 microm) and the tyrosine analogue 4-hydroxyphenylacetic acid (12.5-200 microm), which are both substrates of MPO, indicated that nitrite inhibits MPO-mediated LDL modifications by trapping the enzyme in its inactive compound II form. Nitrites 180-187 myeloperoxidase Homo sapiens 160-163 11054430-7 2001 Furthermore, experiments using ascorbate (12.5-200 microm) and the tyrosine analogue 4-hydroxyphenylacetic acid (12.5-200 microm), which are both substrates of MPO, indicated that nitrite inhibits MPO-mediated LDL modifications by trapping the enzyme in its inactive compound II form. Nitrites 180-187 myeloperoxidase Homo sapiens 197-200 11450112-6 2001 Despite the relatively small number of bacteria so far screened, striking correlations are beginning to emerge between the organization of the nap genes, the physiology of the host, the conditions under which the nap genes are expressed, and even the fate of nitrite, the product of Nap activity. Nitrites 259-266 catenin beta like 1 Homo sapiens 143-146 11450112-6 2001 Despite the relatively small number of bacteria so far screened, striking correlations are beginning to emerge between the organization of the nap genes, the physiology of the host, the conditions under which the nap genes are expressed, and even the fate of nitrite, the product of Nap activity. Nitrites 259-266 catenin beta like 1 Homo sapiens 213-216 11450112-6 2001 Despite the relatively small number of bacteria so far screened, striking correlations are beginning to emerge between the organization of the nap genes, the physiology of the host, the conditions under which the nap genes are expressed, and even the fate of nitrite, the product of Nap activity. Nitrites 259-266 catenin beta like 1 Homo sapiens 283-286 11587563-10 2001 Preincubation of PMNs with nitrite elevated the free radical generation and myeloperoxidase (MPO) release. Nitrites 27-34 myeloperoxidase Rattus norvegicus 76-91 11168643-4 2001 Phorbol 12-myristate 13-acetate (PMA)-stimulated and interferon-gamma (IFN-gamma)-induced superoxide formation was enhanced in peritoneal Mphi lacking TRAP; nitrite production in response to stimulation with lipopolysaccharide (LPS) and IFN-gamma was also increased. Nitrites 157-164 interferon gamma Mus musculus 0-80 11168643-4 2001 Phorbol 12-myristate 13-acetate (PMA)-stimulated and interferon-gamma (IFN-gamma)-induced superoxide formation was enhanced in peritoneal Mphi lacking TRAP; nitrite production in response to stimulation with lipopolysaccharide (LPS) and IFN-gamma was also increased. Nitrites 157-164 interferon gamma Mus musculus 71-80 11587558-8 2001 The increases paralleled the increases in ALT levels with peak levels of serum nitrate plus nitrite at 6 h (168 +/- 27 microM). Nitrites 92-99 glutamic pyruvic transaminase, soluble Mus musculus 42-45 11139389-16 2001 These findings suggest that on formation of an electron transfer complex with azurin, a conformational change in NiR occurs that returns the catalytic Cu centre to a functionally active state capable of binding and reducing nitrite. Nitrites 224-231 nitrite reductase large subunit Achromobacter xylosoxidans 113-116 11149897-8 2001 Consistently with their PARP inhibitory effects, the purines also protected interferon gamma + endotoxin (IFN/LPS) -stimulated RAW macrophages from the inhibition of mitochondrial respiration and inhibited nitrite production from IFN/LPS-stimulated macrophages. Nitrites 206-213 interferon alpha 1 Homo sapiens 76-113 11149897-8 2001 Consistently with their PARP inhibitory effects, the purines also protected interferon gamma + endotoxin (IFN/LPS) -stimulated RAW macrophages from the inhibition of mitochondrial respiration and inhibited nitrite production from IFN/LPS-stimulated macrophages. Nitrites 206-213 interferon alpha 1 Homo sapiens 106-109 11587563-10 2001 Preincubation of PMNs with nitrite elevated the free radical generation and myeloperoxidase (MPO) release. Nitrites 27-34 myeloperoxidase Rattus norvegicus 93-96 11756889-7 2001 Nitrate (NO3) was 49.8 +/- 5.0 micromol/L in patients with PDR and 24.2 +/- 2.8 micromol/L in patients with macula hole; it was also significantly elevated in patients with PDR (P = 0.004, Mann-Whitney), whereas nitrite (NO2) was not detected in this study. Nitrites 212-219 NBL1, DAN family BMP antagonist Homo sapiens 9-12 11178941-8 2001 After IL-1beta stimulation, NO degrees production was highly increased in the supernatants (45-fold increase in nitrite, 60-fold increase in nitrosothiols) as well as in cell lysates (35-fold increase in nitrosothiols). Nitrites 112-119 interleukin 1 beta Homo sapiens 6-14 11575091-7 2001 While the activity of ammonia and nitrite oxidizers within the UBAF were 47.65 and 4.36 mg O2/g VS h, respectively. Nitrites 34-41 immunoglobulin kappa variable 1D-39 Homo sapiens 91-100 11113053-7 2000 However, simultaneous addition of IL-1beta, interferon-gamma, and TNF-alpha or the chemokines to cultures resulted in the induction of iNOS, high levels of nitrite, and a marked trypanocidal activity. Nitrites 156-163 interleukin 1 beta Mus musculus 34-42 11113053-7 2000 However, simultaneous addition of IL-1beta, interferon-gamma, and TNF-alpha or the chemokines to cultures resulted in the induction of iNOS, high levels of nitrite, and a marked trypanocidal activity. Nitrites 156-163 interferon gamma Mus musculus 44-60 11113053-7 2000 However, simultaneous addition of IL-1beta, interferon-gamma, and TNF-alpha or the chemokines to cultures resulted in the induction of iNOS, high levels of nitrite, and a marked trypanocidal activity. Nitrites 156-163 tumor necrosis factor Mus musculus 66-75 11256528-8 2001 TNF-alpha + IFN-gamma increased the nitrite synthesis (52.0 +/- 0.2; p < 0.05 vs. control; n = 6). Nitrites 36-43 tumor necrosis factor Sus scrofa 0-9 11256528-8 2001 TNF-alpha + IFN-gamma increased the nitrite synthesis (52.0 +/- 0.2; p < 0.05 vs. control; n = 6). Nitrites 36-43 interferon gamma Sus scrofa 12-21 11078710-7 2000 Methemoglobin formation increased in proportion to the intracellular nitrite concentration. Nitrites 69-76 hemoglobin subunit gamma 2 Homo sapiens 0-13 11097628-3 2000 LPS/IFN-induced nitrite production, the inducible form of nitric oxide synthase (NOS-2) mRNA, and protein expression were dose dependently inhibited by ANG II on coincubation, which was abolished on ANG II type 2 (AT(2)) receptor blockade by PD-123319. Nitrites 16-23 angiotensinogen Rattus norvegicus 152-158 11104730-0 2000 Surfactant protein A differentially regulates IFN-gamma- and LPS-induced nitrite production by rat alveolar macrophages. Nitrites 73-80 interferon gamma Rattus norvegicus 46-55 11131166-9 2000 Interestingly, compounds almost equally effective in inhibiting nitrite accumulation did not show the same cytotoxic potential, and most sesquiterpene lactones inhibited nitrite accumulation at concentrations where inhibition of NF-kappaB activation was not significant. Nitrites 170-177 nuclear factor kappa B subunit 1 Homo sapiens 229-238 11078710-8 2000 Nitrite reacted with erythrocyte ascorbate, but ascorbate loading of cells decreased nitrite-induced methemoglobin formation only at high nitrite concentrations. Nitrites 85-92 hemoglobin subunit gamma 2 Homo sapiens 101-114 11078710-8 2000 Nitrite reacted with erythrocyte ascorbate, but ascorbate loading of cells decreased nitrite-induced methemoglobin formation only at high nitrite concentrations. Nitrites 138-145 hemoglobin subunit gamma 2 Homo sapiens 101-114 11116101-5 2000 Increased nitrite production by fluvastatin was accompanied by increased iNOS mRNA and protein accumulation. Nitrites 10-17 nitric oxide synthase 2 Rattus norvegicus 73-77 11090106-4 2000 Intraperitoneal injection of NCX-1015 to mice (up to 27.7 micromol kg(-1)) produced nitrite accumulation in the peritoneal cavity maximal at 60 min. Nitrites 84-91 T cell leukemia, homeobox 2 Mus musculus 29-32 11116119-4 2000 In the AdeNOS-treated rats, the local expression of eNOS in the NTS was confirmed by immunohistochemical staining and Western blot analysis for the eNOS protein and by increased production of nitrite/nitrate in the NTS measured by in vivo microdialysis. Nitrites 192-199 nitric oxide synthase 3 Rattus norvegicus 9-13 11194055-10 2000 However, MITU demonstrated a clear inhibition of iNOS at 120 microM with a serum nitrite value of 25.7002 +/- 0.0647, with control values of 24.3421 microM. Nitrites 81-88 nitric oxide synthase 2 Homo sapiens 49-53 11116119-4 2000 In the AdeNOS-treated rats, the local expression of eNOS in the NTS was confirmed by immunohistochemical staining and Western blot analysis for the eNOS protein and by increased production of nitrite/nitrate in the NTS measured by in vivo microdialysis. Nitrites 192-199 nitric oxide synthase 3 Rattus norvegicus 52-56 10967106-0 2000 Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells. Nitrites 133-140 myeloid differentiation primary response gene 88 Mus musculus 18-23 10967106-0 2000 Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells. Nitrites 133-140 interleukin 1 beta Mus musculus 41-58 10967106-0 2000 Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells. Nitrites 133-140 interferon gamma Mus musculus 60-76 10967106-5 2000 Inducible nitric oxide synthase mRNA accumulation and nitrite production, which required the simultaneous presence of IL-1beta and IFN-gamma, were also suppressed by approximately 70%, and these cells were more resistant to cytokine-induced apoptosis as compared with parental cells. Nitrites 54-61 interleukin 1 beta Mus musculus 118-126 10967106-5 2000 Inducible nitric oxide synthase mRNA accumulation and nitrite production, which required the simultaneous presence of IL-1beta and IFN-gamma, were also suppressed by approximately 70%, and these cells were more resistant to cytokine-induced apoptosis as compared with parental cells. Nitrites 54-61 interferon gamma Mus musculus 131-140 11199364-12 2000 This peptone-induced gastrin response during salivary deviation was inhibited by addition of nitrite to the perfusate. Nitrites 93-100 gastrin Homo sapiens 21-28 11199364-13 2000 CONCLUSIONS: Acid-induced inhibition of peptone-stimulated gastrin release is partly dependent on intraluminal NO formed in the reaction between salivary nitrite and gastric acid. Nitrites 154-161 gastrin Homo sapiens 59-66 11067741-7 2000 Stable expression of NOS II was assessed by measuring nitrite accumulation in media every 2 days. Nitrites 54-61 nitric oxide synthase 2, inducible Mus musculus 21-27 11093766-2 2000 Lipopolysaccharides (LPSs) and interferon-gamma stimulated in the same concentration- and time-dependent manner NO synthesis (measured by nitrite accumulation) and L-[(3)H]arginine uptake. Nitrites 138-145 interferon gamma Rattus norvegicus 31-47 11093766-5 2000 The NF-kappaB inhibitors pyrrolidine dithiocarbamate and N(alpha)-p-tosyl-L-lysine chloromethyl ketone abrogated LPS- and interferon-gamma-induced increase of nitrite accumulation and L-[(3)H]arginine uptake as well as up-regulation of iNOS and CAT-2B mRNA. Nitrites 159-166 interferon gamma Rattus norvegicus 122-138 11093766-5 2000 The NF-kappaB inhibitors pyrrolidine dithiocarbamate and N(alpha)-p-tosyl-L-lysine chloromethyl ketone abrogated LPS- and interferon-gamma-induced increase of nitrite accumulation and L-[(3)H]arginine uptake as well as up-regulation of iNOS and CAT-2B mRNA. Nitrites 159-166 nitric oxide synthase 2 Rattus norvegicus 236-240 11093766-5 2000 The NF-kappaB inhibitors pyrrolidine dithiocarbamate and N(alpha)-p-tosyl-L-lysine chloromethyl ketone abrogated LPS- and interferon-gamma-induced increase of nitrite accumulation and L-[(3)H]arginine uptake as well as up-regulation of iNOS and CAT-2B mRNA. Nitrites 159-166 solute carrier family 7 member 2 Rattus norvegicus 245-251 11149241-6 2000 Nitrite accumulation in the culture media of SMCs incubated with TF was determined by diazotization method. Nitrites 0-7 transferrin Homo sapiens 65-67 11149241-14 2000 The nitrite content in the culture medium incubated with TF was three times the content of control. Nitrites 4-11 transferrin Homo sapiens 57-59 11103793-4 2000 After monoculture, treatment of RAW 264.7 cells with IFN-gamma for 24 h generated a large amount of nitrite (NO2-), as reported previously, whereas no increase in NO2- concentration was observed in the IFN-gamma-treated P+ or P-subclones. Nitrites 100-107 interferon gamma Mus musculus 53-62 11020457-5 2000 The polyphenols quercetin and resveratrol at a micromolar range suppressed iNOS gene expression and NO production, as determined by reverse transcription-polymerase chain reaction and nitrite assay. Nitrites 184-191 nitric oxide synthase 2, inducible Mus musculus 75-79 11052959-5 2000 NOS2 activation was estimated by mRNA (RT-PCR) and protein (Western-blot) expression and plasma nitrate/nitrite accumulation. Nitrites 104-111 nitric oxide synthase 2 Rattus norvegicus 0-4 11193088-0 2000 Optical biosensing of nitrite ions using cytochrome cd1 nitrite reductase encapsulated in a sol-gel matrix. Nitrites 22-29 CD1c molecule Homo sapiens 52-55 11193088-3 2000 In order to develop an optical biosensing system for the determination of nitrite ions in environmental waters, cytochrome cd1 nitrite reductase has been extracted and purified from the bacterium Paracoccus pantotrophus. Nitrites 74-81 CD1c molecule Homo sapiens 123-126 11193088-4 2000 The protein has been spectroscopically characterised in solution and important kinetic parameters of nitrite reduction of the cytochrome cd1 enzyme, i.e., Km, Vmax and kcat have been determined. Nitrites 101-108 CD1c molecule Homo sapiens 137-140 11193088-5 2000 The influence of pH on the activity of the cytochrome cd1 has been investigated and the results suggest that this enzyme can be used for the determination of nitrite in the pH range 6-9. Nitrites 158-165 CD1c molecule Homo sapiens 54-57 11193088-6 2000 Biosensing experiments with the cytochrome cd1 in solution suggested that the decrease in intensity of the absorption band associated with the d1 haem (which is the nitrite binding site), at 460 nm, with increasing nitrite concentrations would enable the measurement of this analyte with the optimum limit of detection. Nitrites 165-172 CD1c molecule Homo sapiens 43-46 11193088-6 2000 Biosensing experiments with the cytochrome cd1 in solution suggested that the decrease in intensity of the absorption band associated with the d1 haem (which is the nitrite binding site), at 460 nm, with increasing nitrite concentrations would enable the measurement of this analyte with the optimum limit of detection. Nitrites 215-222 CD1c molecule Homo sapiens 43-46 11070493-7 2000 Interestingly, microglial nitrite production in response to a secreted form of the beta-amyloid precursor protein (sAPP) was unaffected by DHEA. Nitrites 26-33 amyloid beta precursor protein Homo sapiens 83-113 11063722-6 2000 The functional importance of the diminished eNOS expression was revealed by the finding that serum nitrite/nitrate levels among individuals carrying the -786T-->C mutation were significantly lower than among those without the mutation. Nitrites 99-106 nitric oxide synthase 3 Homo sapiens 44-48 11098975-13 2000 iNOS+/+ mice subjected to SMAO had increased plasma concentrations of nitrite (NO2-) and nitrate (NO3-), and the plasma concentrations of NO2- and NO3- were highest in the mice in which bacterial translocation had occurred. Nitrites 70-77 nitric oxide synthase 2, inducible Mus musculus 0-4 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). Nitrites 0-7 interleukin 1 beta Rattus norvegicus 47-69 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). Nitrites 0-7 tumor necrosis factor Rattus norvegicus 73-106 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). Nitrites 0-7 mitogen activated protein kinase 3 Rattus norvegicus 192-195 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). Nitrites 0-7 mitogen activated protein kinase kinase 1 Rattus norvegicus 318-325 11046058-5 2000 Incubating LPS-primed monocytes with NCX-4016 resulted in intracellular NO formation as assessed by measuring nitrite/nitrate, intracellular cGMP concentration, and intracellular NO formation. Nitrites 110-117 T cell leukemia homeobox 2 Homo sapiens 37-40 11069728-6 2000 The effect on NO release in bovine chondrocytes was at the level of inducible nitric oxide synthase (iNOS) gene expression, which was inhibited at similar concentrations as nitrite production. Nitrites 173-180 nitric oxide synthase 2 Bos taurus 68-99 11105912-6 2000 Therefore, we investigated whether IL1beta modified the level of nitrite, a stable metabolite of NO, in Sertoli cells. Nitrites 65-72 interleukin 1 beta Rattus norvegicus 35-42 11105912-7 2000 Dose-response curves to IL1beta for gammaGTP activity and nitrite production were observed. Nitrites 58-65 interleukin 1 beta Rattus norvegicus 24-31 11069728-6 2000 The effect on NO release in bovine chondrocytes was at the level of inducible nitric oxide synthase (iNOS) gene expression, which was inhibited at similar concentrations as nitrite production. Nitrites 173-180 nitric oxide synthase 2 Bos taurus 101-105 11024352-4 2000 The nitrite release of LPS was enhanced significantly by lower concentrations of porin, whereas the effect of IFN-gamma was enhanced by porin at higher concentrations. Nitrites 4-11 toll-like receptor 4 Mus musculus 23-26 11001767-5 2000 Angiotensin II (ANG II, 100 nM) increased EC production of nitrate/nitrite by 2.4-fold. Nitrites 67-74 angiotensinogen Homo sapiens 0-14 11001767-5 2000 Angiotensin II (ANG II, 100 nM) increased EC production of nitrate/nitrite by 2.4-fold. Nitrites 67-74 angiotensinogen Homo sapiens 16-22 10986217-2 2000 We have previously shown that protection against D-galactosamine (D-GalN) induced liver injury by prostaglandin E(1) (PGE(1)) was accompanied by an increase in TNF-alpha and nitrite/nitrate in serum. Nitrites 174-181 galanin and GMAP prepropeptide Rattus norvegicus 68-72 11040335-3 2000 iNOS activity in a cell-free extract of lipopolysaccharide/interferon-gamma-stimulated RAW 264.7 cells was found to be markedly increased, and this increase was prevented by C-1 and C-2, accompanied by the parallel reduction in nitrite accumulation in culture medium. Nitrites 228-235 nitric oxide synthase 2 Homo sapiens 0-4 11040335-3 2000 iNOS activity in a cell-free extract of lipopolysaccharide/interferon-gamma-stimulated RAW 264.7 cells was found to be markedly increased, and this increase was prevented by C-1 and C-2, accompanied by the parallel reduction in nitrite accumulation in culture medium. Nitrites 228-235 interferon gamma Homo sapiens 59-75 11040335-3 2000 iNOS activity in a cell-free extract of lipopolysaccharide/interferon-gamma-stimulated RAW 264.7 cells was found to be markedly increased, and this increase was prevented by C-1 and C-2, accompanied by the parallel reduction in nitrite accumulation in culture medium. Nitrites 228-235 oogenesin 1 Mus musculus 174-177 11040335-3 2000 iNOS activity in a cell-free extract of lipopolysaccharide/interferon-gamma-stimulated RAW 264.7 cells was found to be markedly increased, and this increase was prevented by C-1 and C-2, accompanied by the parallel reduction in nitrite accumulation in culture medium. Nitrites 228-235 complement component 2 (within H-2S) Mus musculus 182-185 11024352-5 2000 Polysaccharide (PS) moiety of LPS stimulated the nitrite release of elicited macrophages by 1.6-fold compared to untreated control. Nitrites 49-56 toll-like receptor 4 Mus musculus 30-33 11024352-17 2000 Therefore, both nitrite release and thymocyte proliferation by LPS could be substituted by PS only. Nitrites 16-23 toll-like receptor 4 Mus musculus 63-66 10976000-1 2000 L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. Nitrites 95-102 interleukin 1 beta Rattus norvegicus 77-86 10921509-6 2000 To determine the role of TNF-alpha on mesangial cell nitrite production, we examined the effect of anti-TNF-alpha antibody on morphine-induced nitrite production. Nitrites 143-150 tumor necrosis factor Homo sapiens 104-113 10921509-12 2000 Anti-TNF-alpha antibody attenuated morphine induced nitrite generation. Nitrites 52-59 tumor necrosis factor Homo sapiens 5-14 11062761-6 2000 IFN gamma alone and in combination with other cytokines was effective in inducing nitrite (NO) production and inducible nitric oxide synthetase (iNOS) expression in macrophages, while IL-1, TNF alpha and IL-6 individually, as well as in various combinations, were not. Nitrites 82-89 interferon gamma Mus musculus 0-9 10976000-2 2000 The thiol depletor diethyl maleate (DEM) and an inhibitor of glutathione reductase 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) reduced IL-1 beta-stimulated nitrite release in islets. Nitrites 156-163 interleukin 1 beta Rattus norvegicus 135-144 10945857-5 2000 to CD-1 mice, serum levels of both TNF-alpha and IL-1beta transiently increased, and peaked at 2 h. After the peak responses of TNF-alpha and IL-1beta, serum levels of nitrite and nitrate increased until at least 8 h. Pretreatment of the mice with cerivastatin (20 mg/kg i.p. Nitrites 168-175 interleukin 1 beta Mus musculus 49-57 10996037-6 2000 The response of IFN-gamma (50 U/ml)-activated macrophages (1.68 nmol nitrite/well) was potentiated (3.52, 4.96, and 4.44 nmol nitrite/well) by fumonisin B(1) (1, 10, and 100 microg/ml, respectively). Nitrites 69-76 interferon gamma Rattus norvegicus 16-25 10996037-6 2000 The response of IFN-gamma (50 U/ml)-activated macrophages (1.68 nmol nitrite/well) was potentiated (3.52, 4.96, and 4.44 nmol nitrite/well) by fumonisin B(1) (1, 10, and 100 microg/ml, respectively). Nitrites 126-133 interferon gamma Rattus norvegicus 16-25 11028657-6 2000 Oxymetazoline and xylometazoline were shown to have a dose dependent inhibitory effect on total iNOS activity indicated by nitrite/nitrate formation in the Griess assay. Nitrites 123-130 nitric oxide synthase 2 Rattus norvegicus 96-100 10964667-0 2000 Nitrite inhalation in rats elevates tissue NOS III expression and alters tyrosine nitration and phosphorylation. Nitrites 0-7 nitric oxide synthase 3 Rattus norvegicus 43-50 10936493-8 2000 Increase of nitrite and nitrate (as an index of NO formation) in the hippocampus, as observed after ischemia, was reduced in animals treated with recombinant human erythropoietin. Nitrites 12-19 erythropoietin Homo sapiens 164-178 10874128-9 2000 Finally, clonidine (1.0 x 10(-4) M to 1.0 x 10(-3) M) dose dependently increased the levels of LPS/IFN-gamma-induced nitrites, the breakdown product of NO, in supernatants of rat C6 glioma cells. Nitrites 117-125 interferon gamma Rattus norvegicus 95-108 10975603-3 2000 Concentration of nitrites in the 24-h supernatants of cells stimulated with recombinant murine IFN-gamma (25 U/ml) reached the following values (mean +/- SEM; in microM): C57BL/10 (33.7+/-1.88) = C57BL/6 (32.1+/-2.10) > SIL (24.0+/-1.55) > CBA/J (18.1+/-1.79) = C3H/HeN (18.0+/-1.10) > DBA/2 (11.4+/-1.16) = DBA/1 (11.0+/-1.20) = Balb/c (11.0+/-1.16). Nitrites 17-25 interferon gamma Mus musculus 95-104 10906155-7 2000 The GH-induced increase in iNOS transcript levels was accompanied by a significant increase in nitrite concentrations in conditioned media, which was blocked by the addition of L-N(G)-monomethylarginine. Nitrites 95-102 nitric oxide synthase 2, inducible Mus musculus 27-31 10963998-11 2000 Studies on glypican-1 glycoforms that recycle suggest that heparan sulfate chains are degraded by endoheparanase at or near GlcNH(2) residues, followed by deaminative cleavage catalysed by NO-derived nitrite. Nitrites 200-207 glypican 1 Homo sapiens 11-21 10983841-8 2000 There was a significant correlation between NOx (nitrite + nitrate) and ET-1 in sera from all 44 women (NP, NTP and PE groups) (p<0.001). Nitrites 49-56 endothelin 1 Homo sapiens 72-76 10916096-10 2000 Kallikrein gene delivery significantly decreased total urinary protein and albumin excretion and increased levels of urinary kinin, nitrite/nitrate, and cGMP levels. Nitrites 132-139 kallikrein related peptidase 4 Homo sapiens 0-10 10944420-3 2000 IFN-gamma alone or combined with LPS induced iNOS expression and increased nitrite production in iNOS(+/+) macrophages, but not in iNOS(-/-) macrophages. Nitrites 75-82 interferon gamma Mus musculus 0-9 10944420-3 2000 IFN-gamma alone or combined with LPS induced iNOS expression and increased nitrite production in iNOS(+/+) macrophages, but not in iNOS(-/-) macrophages. Nitrites 75-82 nitric oxide synthase 2, inducible Mus musculus 97-101 10944420-3 2000 IFN-gamma alone or combined with LPS induced iNOS expression and increased nitrite production in iNOS(+/+) macrophages, but not in iNOS(-/-) macrophages. Nitrites 75-82 nitric oxide synthase 2, inducible Mus musculus 97-101 10923019-9 2000 Wound fluid nitrite/nitrate levels were higher in WT than iNOS-KO animals but were not significantly influenced by additional arginine. Nitrites 12-19 nitric oxide synthase 2, inducible Mus musculus 58-62 10975603-3 2000 Concentration of nitrites in the 24-h supernatants of cells stimulated with recombinant murine IFN-gamma (25 U/ml) reached the following values (mean +/- SEM; in microM): C57BL/10 (33.7+/-1.88) = C57BL/6 (32.1+/-2.10) > SIL (24.0+/-1.55) > CBA/J (18.1+/-1.79) = C3H/HeN (18.0+/-1.10) > DBA/2 (11.4+/-1.16) = DBA/1 (11.0+/-1.20) = Balb/c (11.0+/-1.16). Nitrites 17-25 Scl/Tal1 interrupting locus Mus musculus 223-226 10913595-6 2000 At 200 microM, they inhibited by 32.2-72.4% nitrite accumulation induced by lipopolysaccharide (0.1 microgram/ml)/interferon-gamma (100 U/ml) in mouse peritoneal exudate macrophages. Nitrites 44-51 interferon gamma Mus musculus 114-130 10913595-8 2000 Instead, they showed a clear scavenging effect (6.9-43.9%) at the low concentrations of 2-10 microM of about 12 microM nitrite generated from an NO donor, 1-propanamine-3-hydroxy-2-nitroso-1-propylhydrazino (PAPA NONOate). Nitrites 119-126 pappalysin 1 Homo sapiens 208-212 10930185-4 2000 RESULTS: Ouabain (0.01-1 mmol/l) further enhanced interleukin-1beta (II-1beta)-induced nitrite production by WKY and SHR VSMC, although a more pronounced effect was observed in SHR cells (maximum response 52.1 +/- 5.2 and 71.2 +/- 6.4% of 11-1beta effect in WKY and SHR cells, respectively). Nitrites 87-94 interleukin 1 beta Rattus norvegicus 50-67 10777476-0 2000 Mechanism of reaction of myeloperoxidase with nitrite. Nitrites 46-53 myeloperoxidase Homo sapiens 25-40 10777476-2 2000 In order to clarify if nitrite could be a physiological substrate of myeloperoxidase, we investigated the reactions of the ferric enzyme and its redox intermediates, compound I and compound II, with nitrite under pre-steady state conditions by using sequential mixing stopped-flow analysis in the pH range 4-8. Nitrites 23-30 myeloperoxidase Homo sapiens 69-84 10777476-2 2000 In order to clarify if nitrite could be a physiological substrate of myeloperoxidase, we investigated the reactions of the ferric enzyme and its redox intermediates, compound I and compound II, with nitrite under pre-steady state conditions by using sequential mixing stopped-flow analysis in the pH range 4-8. Nitrites 199-206 myeloperoxidase Homo sapiens 69-84 10777476-3 2000 At 15 degrees C the rate of formation of the low spin MPO-nitrite complex is (2.5 +/- 0.2) x 10(4) m(-1) s(-1) at pH 7 and (2.2 +/- 0.7) x 10(6) m(-1) s(-1) at pH 5. Nitrites 58-65 myeloperoxidase Homo sapiens 54-57 10777476-5 2000 Nitrite is oxidized by two one-electron steps in the MPO peroxidase cycle. Nitrites 0-7 myeloperoxidase Homo sapiens 53-56 10880577-8 2000 We also show that methemoglobin does not form with peroxynitrite any spectrally detectable product, but with contaminations of nitrite and H(2)O(2) present in the peroxynitrite sample. Nitrites 57-64 hemoglobin subunit gamma 2 Homo sapiens 18-31 10909895-5 2000 In addition, an overproduction of nitric oxide (NO, examined by its metabolites nitrite/nitrate) by inducible NO synthase (iNOS, examined by western blot analysis) is attenuated by pretreatment of LPS rats with terbutaline. Nitrites 80-87 nitric oxide synthase 2 Rattus norvegicus 100-121 10909895-5 2000 In addition, an overproduction of nitric oxide (NO, examined by its metabolites nitrite/nitrate) by inducible NO synthase (iNOS, examined by western blot analysis) is attenuated by pretreatment of LPS rats with terbutaline. Nitrites 80-87 nitric oxide synthase 2 Rattus norvegicus 123-127 10747881-5 2000 Here we show that exposure of human recombinant alpha-synuclein to nitrating agents (peroxynitrite/CO(2) or myeloperoxidase/H(2)O(2)/nitrite) induces formation of nitrated alpha-synuclein oligomers that are highly stabilized due to covalent cross-linking via the oxidation of tyrosine to form o,o"-dityrosine. Nitrites 91-98 synuclein alpha Homo sapiens 48-63 10747881-5 2000 Here we show that exposure of human recombinant alpha-synuclein to nitrating agents (peroxynitrite/CO(2) or myeloperoxidase/H(2)O(2)/nitrite) induces formation of nitrated alpha-synuclein oligomers that are highly stabilized due to covalent cross-linking via the oxidation of tyrosine to form o,o"-dityrosine. Nitrites 91-98 synuclein alpha Homo sapiens 172-187 10843690-2 2000 sPLA2 by itself barely stimulated nitrite production and iNOS expression in Raw264.7 cells. Nitrites 34-41 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 0-5 11126085-6 2000 Nitrite dipstick test correctly identified 13 of the 45 urine samples with proven UTI (28.9% sensitivity). Nitrites 0-7 alpha-1-microglobulin/bikunin precursor Homo sapiens 82-85 11126085-8 2000 The nitrite dipstick test was found to be less sensitive than significant leukocyturia in detecting UTI. Nitrites 4-11 alpha-1-microglobulin/bikunin precursor Homo sapiens 100-103 10843690-8 2000 Moreover, when we transfected cDNA-encoding type II sPLA2, we observed that the sPLA2-transfected cells produced two times more nitrites than the empty vector or cytosolic PLA2-transfected cells. Nitrites 128-136 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 52-57 10843690-8 2000 Moreover, when we transfected cDNA-encoding type II sPLA2, we observed that the sPLA2-transfected cells produced two times more nitrites than the empty vector or cytosolic PLA2-transfected cells. Nitrites 128-136 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 80-85 10843690-8 2000 Moreover, when we transfected cDNA-encoding type II sPLA2, we observed that the sPLA2-transfected cells produced two times more nitrites than the empty vector or cytosolic PLA2-transfected cells. Nitrites 128-136 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 53-57 10843690-10 2000 We found that the NF-kappa B inhibitor pyrrolidinedithiocarbamate prevented nitrite production, iNOS induction, and mRNA accumulation by sPLA2 plus LPS in Raw264.7 cells. Nitrites 76-83 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 18-28 10843690-13 2000 It stimulates iNOS expression and nitrite production by a mechanism that requires the activation of NF-kappa B. Nitrites 34-41 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 100-110 10807981-9 2000 Indeed, nitrite/nitrate was positive in 70% of AFP-negative HCC patients. Nitrites 8-15 alpha fetoprotein Homo sapiens 47-50 11483289-4 2000 Others have shown that nitrite exacerbates the ACE dysfunction of cultured endothelial cells in contact with activated polymorphonuclear neutrophils (PMN). Nitrites 23-30 angiotensin I converting enzyme Rattus norvegicus 47-50 10918945-0 2000 Long-term effect of antihypertensive therapy with calcium antagonist or angiotensin converting enzyme inhibitor on serum nitrite/nitrate levels in human essential hypertension. Nitrites 121-128 angiotensin I converting enzyme Homo sapiens 72-101 10840402-0 2000 Markedly elevated nitrate/nitrite levels in the cerebrospinal fluid of children with progressive encephalopathy with edema, hypsarrhythmia, and optic atrophy (PEHO syndrome). Nitrites 26-33 coiled-coil domain containing 88A Homo sapiens 159-163 11227456-7 2000 The method was applied to the determination of nitrite in tap and river water. Nitrites 47-54 SEC14 like lipid binding 2 Homo sapiens 58-61 10856269-4 2000 Incubation of cultures with interleukin-1beta (10 ng/mL) for 24 hours caused a significant increase in the production of nitrite, a stable metabolite of NO, in cultured rat vascular smooth muscle cells. Nitrites 121-128 interleukin 1 beta Rattus norvegicus 28-45 10856269-5 2000 The PPARgamma agonists troglitazone and 15-deoxy-triangle up(12,14)-prostaglandin J(2) (15d-PG J(2)) dose-dependently inhibited nitrite production by interleukin-1beta-stimulated vascular smooth muscle cells. Nitrites 128-135 peroxisome proliferator-activated receptor gamma Rattus norvegicus 4-13 10856269-5 2000 The PPARgamma agonists troglitazone and 15-deoxy-triangle up(12,14)-prostaglandin J(2) (15d-PG J(2)) dose-dependently inhibited nitrite production by interleukin-1beta-stimulated vascular smooth muscle cells. Nitrites 128-135 interleukin 1 beta Rattus norvegicus 150-167 10856269-6 2000 Decreased interleukin-1beta-induced nitrite production by the PPARgamma agonists was accompanied by decreased inducible NO synthase mRNA and protein accumulation. Nitrites 36-43 interleukin 1 beta Rattus norvegicus 10-27 10856269-6 2000 Decreased interleukin-1beta-induced nitrite production by the PPARgamma agonists was accompanied by decreased inducible NO synthase mRNA and protein accumulation. Nitrites 36-43 peroxisome proliferator-activated receptor gamma Rattus norvegicus 62-71 10933013-4 2000 S-antigen induced significant, dose-dependent nitrite production in both RAW 264.7 and rat peritoneal macrophages. Nitrites 46-53 S-antigen visual arrestin Rattus norvegicus 0-9 10781002-15 2000 LPS pretreatment increased serum corticosterone levels in both mice, while it increased the serum nitrate/nitrite levels in wild-type but not in iNOS deficient mice. Nitrites 106-113 toll-like receptor 4 Mus musculus 0-3 10818069-3 2000 Sodium salicylate, aspirin, and indomethacin dose-dependently enhanced nitrite production by interleukin (IL)-1beta-stimulated VSMCs at therapeutic plasma concentration ranges. Nitrites 71-78 interleukin 1 beta Rattus norvegicus 93-115 10818069-4 2000 Increased nitrite production by aspirin-like drugs was accompanied by increased iNOS mRNA and protein accumulation in VSMCs. Nitrites 10-17 nitric oxide synthase 2 Rattus norvegicus 80-84 10818069-7 2000 The 12-LO product 12-HETE dose-dependently enhanced nitrite production by IL-1beta-stimulated VSMCs, whereas the 15-LO product 15-HETE did not. Nitrites 52-59 interleukin 1 beta Rattus norvegicus 74-82 10800933-5 2000 The results demonstrate that KCI at 25-75 mM potently inhibits astrocyte nitrite production stimulated by interleukin-1 (IL-1)/interferon-gamma (IFNgamma). Nitrites 73-80 interferon gamma Homo sapiens 127-143 10800933-5 2000 The results demonstrate that KCI at 25-75 mM potently inhibits astrocyte nitrite production stimulated by interleukin-1 (IL-1)/interferon-gamma (IFNgamma). Nitrites 73-80 interferon gamma Homo sapiens 145-153 10766781-0 2000 Nitrite as a substrate and inhibitor of myeloperoxidase. Nitrites 0-7 myeloperoxidase Homo sapiens 40-55 10766781-5 2000 Nitrite was found to be a poor substrate for myeloperoxidase but an excellent inhibitor of its chlorination activity. Nitrites 0-7 myeloperoxidase Homo sapiens 45-60 10766781-7 2000 In the presence of physiological concentrations of nitrite and chloride, myeloperoxidase catalyzed little nitration of tyrosyl residues in a heptapeptide. Nitrites 51-58 myeloperoxidase Homo sapiens 73-88 10766781-11 2000 With neutrophils, myeloperoxidase-dependent nitration required a high concentration of nitrite (1 mM), was doubled by tyrosine, and increased 4-fold by superoxide dismutase. Nitrites 87-94 myeloperoxidase Homo sapiens 18-33 10766781-13 2000 We propose that at sites of inflammation myeloperoxidase will nitrate proteins, even though nitrite is a poor substrate, because the co-substrate tyrosine will be available to facilitate the reaction. Nitrites 92-99 myeloperoxidase Homo sapiens 41-56 10736124-8 2000 RESULTS: There were no statistically significant differences in the control and treatment groups with respect to baseline hemoglobin or methemoglobin concentrations, as well as nitrite-induced methemoglobin concentrations at the initiation of treatment (0.85+/-0.06 g/dL, 0.88+/-0.04 g/dL; mean+/-SEM; P =.31). Nitrites 177-184 hemoglobin subunit gamma 2 Homo sapiens 193-206 10754630-8 2000 In contrast, in cells costimulated by lipopolysaccharide plus gamma-interferon, volatile anesthetics significantly increased nitrite production and iNOS expression independent of ionomycin and other mediators studied. Nitrites 125-132 interferon gamma Mus musculus 62-78 10746650-8 2000 E2 treatment decreases NO production and the activity of iNOS with consequent diminished nitrite synthesis and nitrosine accumulation. Nitrites 89-96 nitric oxide synthase 2 Rattus norvegicus 57-61 10775561-3 2000 The effect of N-acetyl-L-cysteine on potentiating interleukin-1beta-induced nitrite production and iNOS expression was mimicked either by the enantiomers, L-cysteine and D-cysteine, or by a non-thiol-containing antioxidant, L-ascorbic acid. Nitrites 76-83 interleukin 1 beta Rattus norvegicus 50-67 10782904-9 2000 CONCLUSIONS: Our experiments show that in rat hepatocytes: 1) iNOS is induced by low oxygen tension; 2) the modification occurs at the transcriptional level; 3) the enzyme at 5% oxygen is able to catalyze the synthesis of NO, although no nitrites are accumulated in the medium. Nitrites 238-246 nitric oxide synthase 2 Rattus norvegicus 62-66 10713088-0 2000 Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase. Nitrites 13-20 xanthine dehydrogenase Homo sapiens 50-73 10802225-4 2000 Neutrophils undergoing spontaneous apoptosis in culture as assessed by annexin V binding generated significant amounts of nitrite. Nitrites 122-129 annexin A5 Homo sapiens 71-80 10802225-5 2000 Incubation with agonistic anti-Fas monoclonal antibody or tumor necrosis factor-alpha (TNF-alpha) enhanced neutrophil apoptosis at 6 h, although it decreased nitrite accumulation. Nitrites 158-165 tumor necrosis factor Homo sapiens 58-85 10802225-5 2000 Incubation with agonistic anti-Fas monoclonal antibody or tumor necrosis factor-alpha (TNF-alpha) enhanced neutrophil apoptosis at 6 h, although it decreased nitrite accumulation. Nitrites 158-165 tumor necrosis factor Homo sapiens 87-96 10660117-3 2000 Treatment of P ll cells with interferon-gamma and lipopolysaccharide resulted in a 23-fold increase in nitrite production and induced expression of iNOS protein. Nitrites 103-110 interferon gamma Homo sapiens 29-45 10660117-4 2000 The increase in nitrite levels was attenuated by the non-selective nitric oxide synthase (NOS) inhibitor N i-nitro-L-arginine methyl ester, hut not the neuronal NOS inhibitor 7-nitroindazole. Nitrites 16-23 nitric oxide synthase 2 Homo sapiens 67-88 10660117-6 2000 We have observed that Pl 1 cells grown under these culture conditions express basal iNOS activity, as evidenced by a 5-fold increase in nitrite accumulation over a 48-hr period, compared with that in cells grown in non-modified serum, which was inhibited by the selective iNOS inhibitor L.N6-(1-iminoethyl)-lysine. Nitrites 136-143 nitric oxide synthase 2 Homo sapiens 84-88 10705297-3 2000 IFN-gamma, TNF-alpha and IL-10 have been shown to be involved in the regulation of LPS-induced serum levels of the NO-oxidation products nitrate and nitrite. Nitrites 149-156 tumor necrosis factor Mus musculus 11-20 10705297-3 2000 IFN-gamma, TNF-alpha and IL-10 have been shown to be involved in the regulation of LPS-induced serum levels of the NO-oxidation products nitrate and nitrite. Nitrites 149-156 interleukin 10 Mus musculus 25-30 12212263-4 2000 The results suggest that this method is better than ratio derivative spectrum method and it can be applied for determining nitrate and nitrite (NO3- and NO2-) in environment water samples. Nitrites 135-142 NBL1, DAN family BMP antagonist Homo sapiens 144-147 10671549-4 2000 Cells transfected with either wild type (WT) or mutant (G93A) Cu, Zn-superoxide dismutase (Cu,Zn-SOD) produced comparable amounts of nitrite/nitrate but showed different degree of apoptosis. Nitrites 133-140 superoxide dismutase 1 Homo sapiens 62-89 10671549-4 2000 Cells transfected with either wild type (WT) or mutant (G93A) Cu, Zn-superoxide dismutase (Cu,Zn-SOD) produced comparable amounts of nitrite/nitrate but showed different degree of apoptosis. Nitrites 133-140 superoxide dismutase 1 Homo sapiens 91-100 10683447-6 2000 We conclude that plant NR produces both NO and its toxic derivative, peroxynitrite, under aerobic conditions when nitrite is provided as the substrate for NR. Nitrites 75-82 nitrate reductase [NADH] 1 Zea mays 23-25 10683447-6 2000 We conclude that plant NR produces both NO and its toxic derivative, peroxynitrite, under aerobic conditions when nitrite is provided as the substrate for NR. Nitrites 75-82 nitrate reductase [NADH] 1 Zea mays 155-157 10728381-11 2000 TNF alpha induced a concentration-dependent increase in iNOS mRNA expression and nitrite production as well as significant apoptosis of cardiomyocytes in the wild type mice (n = 4, P < 0.01). Nitrites 81-88 tumor necrosis factor Mus musculus 0-9 10672850-5 2000 Bradykinin and kallikrein all significantly increased nitrite release from coronary microvessels in a concentration-dependent manner. Nitrites 54-61 kininogen 1 Canis lupus familiaris 0-10 10640621-7 2000 The influence of neurons on glial inflammation was partly due to the cell-cell contacts between neurons and glia via neural cell adhesion molecules (NCAM) because NCAM significantly reduced LPS-stimulated nitrite production. Nitrites 205-212 neural cell adhesion molecule 1 Rattus norvegicus 149-153 10640621-7 2000 The influence of neurons on glial inflammation was partly due to the cell-cell contacts between neurons and glia via neural cell adhesion molecules (NCAM) because NCAM significantly reduced LPS-stimulated nitrite production. Nitrites 205-212 neural cell adhesion molecule 1 Rattus norvegicus 163-167 10648857-3 2000 Here, we have optimized a previously established test based on assessing the formation of neopterin or nitrite in interferon-gamma-treated human (THP-1) or murine (J774A.1, RAW264.7) monocytoid cell lines, respectively, in response to bacterial pyrogens. Nitrites 103-110 interferon gamma Homo sapiens 114-130 10648857-3 2000 Here, we have optimized a previously established test based on assessing the formation of neopterin or nitrite in interferon-gamma-treated human (THP-1) or murine (J774A.1, RAW264.7) monocytoid cell lines, respectively, in response to bacterial pyrogens. Nitrites 103-110 GLI family zinc finger 2 Homo sapiens 146-151 10644422-4 2000 We have previously observed that nitrite reactions with the matrix proteins elastin and collagen produce damaging effects that mimic those observed in age- and smoking-related illnesses. Nitrites 33-40 elastin Homo sapiens 76-83 10642319-4 2000 Nitrate/nitrite production in AdeNOS-transduced ZG cells increased from 0.15+/-0.01 to 0.27+/-0.01 micromol/L after stimulation with 1 nmol/L angiotensin II. Nitrites 8-15 angiotensinogen Homo sapiens 142-156 10642319-5 2000 The treatment of AdeNOS-transduced cells with 30 micromol/L L-nitro-arginine decreased angiotensin II-stimulated nitrite production from 0.27+/-0. Nitrites 113-120 angiotensinogen Homo sapiens 87-101 10642319-7 2000 Basal and angiotensin II-stimulated nitrite production was not increased in AdbetaGal-transduced or control cells. Nitrites 36-43 angiotensinogen Homo sapiens 10-24 10684988-7 2000 The number of intracellular parasites in PE was markedly decreased in young born to IFN-gamma-treated mothers, this not being accompanied by higher nitrite levels in culture supernatants. Nitrites 148-155 interferon gamma Rattus norvegicus 84-93 10653521-2 2000 Nitrite production was inhibited by the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine, as well as the transcription inhibitor actinomycin D. Nitrites 0-7 nitric oxide synthase 2 Rattus norvegicus 40-71 10653521-2 2000 Nitrite production was inhibited by the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine, as well as the transcription inhibitor actinomycin D. Nitrites 0-7 nitric oxide synthase 2 Rattus norvegicus 73-77 10653521-3 2000 Increases in iNOS mRNA, protein, and activity levels correlated with the formation of nitrite. Nitrites 86-93 nitric oxide synthase 2 Rattus norvegicus 13-17 10653521-4 2000 iNOS mRNA was first detectable 2 h after the onset of hepatocyte incubations and peaked at 4 h. These results indicate that nitrite formation is a result of the large scale production of nitric oxide (NO) by hepatocytes in response to the time-dependent induction of iNOS. Nitrites 124-131 nitric oxide synthase 2 Rattus norvegicus 0-4 10653521-4 2000 iNOS mRNA was first detectable 2 h after the onset of hepatocyte incubations and peaked at 4 h. These results indicate that nitrite formation is a result of the large scale production of nitric oxide (NO) by hepatocytes in response to the time-dependent induction of iNOS. Nitrites 124-131 nitric oxide synthase 2 Rattus norvegicus 267-271 10600756-3 1999 The tyrosine kinase inhibitor genistein decreased LPS- and GM-CSF-induced nitrite (NO(-2)) production. Nitrites 74-81 toll-like receptor 4 Mus musculus 50-53 10571667-4 1999 Similarly, significant increases in myeloperoxidase activity, a marker for neutrophil and macrophage content, were observed in the peritoneal lavage cells after intraperitoneal injection of mastoparan M. However, induction of nitrite by mastoparan M was completely inhibited by simultaneous addition of antimouse TNF-alpha antibody to the macrophage cultures. Nitrites 226-233 myeloperoxidase Mus musculus 36-51 10571667-4 1999 Similarly, significant increases in myeloperoxidase activity, a marker for neutrophil and macrophage content, were observed in the peritoneal lavage cells after intraperitoneal injection of mastoparan M. However, induction of nitrite by mastoparan M was completely inhibited by simultaneous addition of antimouse TNF-alpha antibody to the macrophage cultures. Nitrites 226-233 tumor necrosis factor Mus musculus 313-322 10601128-4 1999 The inhibition of either the ERK pathway or p38 MAPK activity with selective inhibitors blocked cytokine-induced iNOS protein and nitrite production. Nitrites 130-137 mitogen-activated protein kinase 1 Homo sapiens 29-32 10601128-4 1999 The inhibition of either the ERK pathway or p38 MAPK activity with selective inhibitors blocked cytokine-induced iNOS protein and nitrite production. Nitrites 130-137 mitogen-activated protein kinase 14 Homo sapiens 44-47 10601128-4 1999 The inhibition of either the ERK pathway or p38 MAPK activity with selective inhibitors blocked cytokine-induced iNOS protein and nitrite production. Nitrites 130-137 mitogen-activated protein kinase 1 Homo sapiens 48-52 10586945-7 1999 Superoxide production was measured by superoxide dismutase-inhibitable reduction of cytochrome C. RESULTS: Both S-antigen and IRBP induced significant, dose-dependent nitrite production in RAW 264.7 and rat peritoneal macrophages. Nitrites 167-174 S-antigen visual arrestin Rattus norvegicus 112-121 10586945-7 1999 Superoxide production was measured by superoxide dismutase-inhibitable reduction of cytochrome C. RESULTS: Both S-antigen and IRBP induced significant, dose-dependent nitrite production in RAW 264.7 and rat peritoneal macrophages. Nitrites 167-174 retinol binding protein 3 Rattus norvegicus 126-130 10737225-5 1999 Classical NOS inhibitor (L-nitro arginine) and iNOS-specific inhibitors completely blocked the increased nitrite level induced by VK2 treatment, but D-nitro arginine could not it. Nitrites 105-112 nitric oxide synthase 2 Bos taurus 47-51 10761399-4 1999 IRBP induced significant, dose-dependent nitrite production in both RAW 264.7 and rat peritoneal macrophages. Nitrites 41-48 retinol binding protein 3 Rattus norvegicus 0-4 10583867-5 1999 Further studies in CBA/J mice demonstrated that mice infected with PTN elicited a significantly higher lymphoproliferative response to crosslinked anti-CD3 mAb or Con A than PLK infected mice, and augmented production of TNFalpha, lower levels of nitrite and a higher number of NK cells. Nitrites 247-254 pleiotrophin Mus musculus 67-70 10707282-2 1999 In normal erythrocytes, the interaction of intracellular oxyhemoglobin with nitrite ions results in the formation of methemoglobin, whereas in metabolically exhausted erythrocytes, this leads predominantly to the formation of nitrite methemoglobin. Nitrites 76-83 hemoglobin subunit gamma 2 Homo sapiens 117-130 10707282-2 1999 In normal erythrocytes, the interaction of intracellular oxyhemoglobin with nitrite ions results in the formation of methemoglobin, whereas in metabolically exhausted erythrocytes, this leads predominantly to the formation of nitrite methemoglobin. Nitrites 76-83 hemoglobin subunit gamma 2 Homo sapiens 234-247 10707282-3 1999 The nitrite methemoglobin reacts with hydrogen peroxide to form reactive intermediates (e.g. peroxynitrous acid) and the products of hemoglobin destruction. Nitrites 4-11 hemoglobin subunit gamma 2 Homo sapiens 12-25 10527657-1 1999 The level of nitrite accumulation in the culture media of astrocytes activated with lipopolysaccharide (LPS) and interferon-gamma (IFN) was decreased by pretreatment of cells with LY294002, a quercetin derivative developed for phosphatidylinositol-3-kinase (PI3K) inhibitor, in a dose-dependent manner. Nitrites 13-20 interferon gamma Mus musculus 113-135 10527657-1 1999 The level of nitrite accumulation in the culture media of astrocytes activated with lipopolysaccharide (LPS) and interferon-gamma (IFN) was decreased by pretreatment of cells with LY294002, a quercetin derivative developed for phosphatidylinositol-3-kinase (PI3K) inhibitor, in a dose-dependent manner. Nitrites 13-20 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 227-256 10532951-4 1999 Similarly, incubation of NRVMs with IL-1beta and IFNgamma for 48 hours resulted in an increase in iNOS expression, nitrite production, and programmed cell death. Nitrites 115-122 interleukin 1 beta Rattus norvegicus 36-44 10532951-4 1999 Similarly, incubation of NRVMs with IL-1beta and IFNgamma for 48 hours resulted in an increase in iNOS expression, nitrite production, and programmed cell death. Nitrites 115-122 interferon gamma Rattus norvegicus 49-57 10532951-5 1999 Both the cytokine-induced nitrite accumulation and myocyte apoptosis could be completely prevented by the nonselective NOS inhibitor L-nitroarginine (3 mmol/L) or the specific iNOS inhibitor 2-amino-5, 6-dihydro-6-methyl-4H-1,3-thiazine (AMT, 100 micromol/L). Nitrites 26-33 nitric oxide synthase 2 Rattus norvegicus 176-180 10529453-4 1999 The expression of the potentially therapeutic ecNOS gene was evidenced by confirmation of ecNOS mRNA generation, indirect detection of active ecNOS protein and by measurement of nitrite ion accumulation in the medium from the transfected cell cultures. Nitrites 178-185 nitric oxide synthase 3 Rattus norvegicus 46-51 10523329-2 1999 Interleukin-1beta induced the production of nitrite, a stable metabolite of nitric oxide in a time- and dose-dependent manner. Nitrites 44-51 interleukin 1 beta Rattus norvegicus 0-17 10510444-3 1999 2 Treatment with LPS/IFN-gamma and mixed cytokines for 24 h elicited the induction of iNOS activity as determined by nitrite accumulation in the culture medium and assay of enzyme activity. Nitrites 117-124 interferon gamma Rattus norvegicus 21-30 10510444-3 1999 2 Treatment with LPS/IFN-gamma and mixed cytokines for 24 h elicited the induction of iNOS activity as determined by nitrite accumulation in the culture medium and assay of enzyme activity. Nitrites 117-124 nitric oxide synthase 2 Rattus norvegicus 86-90 10477397-6 1999 Following a 24 hours exposure to IL-1beta or IL-1beta + IFN-gamma, pancreatic islets isolated from IRF-1-/- mice presented a 30-50% reduction in medium nitrite accumulation and inducible NO-synthase (iNOS) expression. Nitrites 152-159 interleukin 1 beta Mus musculus 33-41 10477397-6 1999 Following a 24 hours exposure to IL-1beta or IL-1beta + IFN-gamma, pancreatic islets isolated from IRF-1-/- mice presented a 30-50% reduction in medium nitrite accumulation and inducible NO-synthase (iNOS) expression. Nitrites 152-159 interleukin 1 beta Mus musculus 45-53 10477397-6 1999 Following a 24 hours exposure to IL-1beta or IL-1beta + IFN-gamma, pancreatic islets isolated from IRF-1-/- mice presented a 30-50% reduction in medium nitrite accumulation and inducible NO-synthase (iNOS) expression. Nitrites 152-159 interferon gamma Mus musculus 56-65 10477397-6 1999 Following a 24 hours exposure to IL-1beta or IL-1beta + IFN-gamma, pancreatic islets isolated from IRF-1-/- mice presented a 30-50% reduction in medium nitrite accumulation and inducible NO-synthase (iNOS) expression. Nitrites 152-159 interferon regulatory factor 1 Mus musculus 99-104 10477397-7 1999 Interestingly, both wt and IRF-1-/- purified beta-cells failed to produce NO in response to IL-1beta alone, but presented a similar increase in nitrite accumulation and iNOS expression following exposure to IL-1beta + IFN-gamma. Nitrites 144-151 interferon regulatory factor 1 Mus musculus 27-32 10489101-10 1999 rHuEPO inhibited not only IL-1beta induced nitrite production, but also the expression of iNOS mRNA and protein. Nitrites 43-50 interleukin 1 beta Homo sapiens 26-34 10489101-13 1999 The inhibitory effect of rHuEPO on IL-1beta induced nitrite production was also eliminated in PKC depleted cells or in the existence of anti-EpoR antibody. Nitrites 52-59 interleukin 1 beta Homo sapiens 35-43 10489101-13 1999 The inhibitory effect of rHuEPO on IL-1beta induced nitrite production was also eliminated in PKC depleted cells or in the existence of anti-EpoR antibody. Nitrites 52-59 erythropoietin receptor Homo sapiens 141-145 10462538-9 1999 Attendant with the reduction of plasma nitrite/nitrate concentration by single and repeated doses of NOS inhibitors, activity and content of FMO1 in liver microsomes isolated from these NOS inhibitor cotreated rats were restored partially (in single-dose inhibitors) or completely (in repeat doses). Nitrites 39-46 flavin containing dimethylaniline monoxygenase 1 Rattus norvegicus 141-145 10690351-5 1999 RESULTS: ER alpha gene transfection of endothelial cells produced a 2-3-fold increase in eNOS mRNA and protein levels as well as a significant increase (P < 0.05) in NOS activity as measured by citrulline assay and nitrite accumulation in the media in response to bradykinin stimulation. Nitrites 218-225 estrogen receptor 1 Bos taurus 9-17 10690352-6 1999 RESULTS: Cultured endothelial cells showed almost 100% transduction with both viruses and a dose response of eNOS expression showed a five-fold increase in nitrite production for AdCMVeNOS with no change for beta-galactosidase-containing virus. Nitrites 156-163 nitric oxide synthase 3 Rattus norvegicus 109-113 10444534-4 1999 KGF given before transplantation inhibited the T cell-induced increase in bronchoalveolar lavage fluid protein, TNF-alpha, IFN-gamma, and nitrite levels measured on day 7 after transplantation without modifying cellular infiltration or proinflammatory cytokines and inducible. Nitrites 138-145 fibroblast growth factor 7 Mus musculus 0-3 10438436-7 1999 In the DHEA-S group, plasma circulating nitrate and nitrite increased significantly at 10 and 30 min after DHEA-S administration respectively (P < 0.05). Nitrites 52-59 sulfotransferase family 2A member 1 Homo sapiens 7-13 10437781-0 1999 Nitrogen dioxide radical generated by the myeloperoxidase-hydrogen peroxide-nitrite system promotes lipid peroxidation of low density lipoprotein. Nitrites 76-83 myeloperoxidase Homo sapiens 42-57 10437781-3 1999 We found that myeloperoxidase, an H2O2-generating system and nitrite (NO2-) peroxidized LDL lipids. Nitrites 61-68 myeloperoxidase Homo sapiens 14-29 10381925-10 1999 Plasma nitrite/nitrate levels and hepatic NOS activity were increased significantly by CCl4 treatment. Nitrites 7-14 C-C motif chemokine ligand 4 Rattus norvegicus 87-91 10412764-6 1999 METHODS AND RESULTS: Treatment of mesangial cells with interleukin-1 beta (IL-1 beta) induced iNOS activity measured as nitrite levels in cell culture supernatants. Nitrites 120-127 interleukin 1 beta Rattus norvegicus 55-73 10412764-6 1999 METHODS AND RESULTS: Treatment of mesangial cells with interleukin-1 beta (IL-1 beta) induced iNOS activity measured as nitrite levels in cell culture supernatants. Nitrites 120-127 interleukin 1 beta Rattus norvegicus 75-84 10412764-6 1999 METHODS AND RESULTS: Treatment of mesangial cells with interleukin-1 beta (IL-1 beta) induced iNOS activity measured as nitrite levels in cell culture supernatants. Nitrites 120-127 nitric oxide synthase 2 Rattus norvegicus 94-98 10412764-8 1999 In contrast, coincubation with LPC and IL-1 beta resulted in a markedly higher nitrite content compared to that after incubation with IL-1 beta alone. Nitrites 79-86 interleukin 1 beta Rattus norvegicus 39-48 10412764-8 1999 In contrast, coincubation with LPC and IL-1 beta resulted in a markedly higher nitrite content compared to that after incubation with IL-1 beta alone. Nitrites 79-86 interleukin 1 beta Rattus norvegicus 134-143 11798681-5 1999 RESULTS: IL-1 beta induced a significant increase in nitrite production, a decrease of islet cell DNA and insulin content and reduction of cell activity (MTT, P < 0.001); these changes were blocked by L-NMMA (P < 0.001). Nitrites 53-60 interleukin 1 beta Rattus norvegicus 9-18 10359564-4 1999 Incubation of LDL with isolated MPO, an H2O2-generating system, and nitrite (NO2-)-- a major end-product of NO metabolism--resulted in nitration of apolipoprotein B 100 tyrosyl residues and initiation of LDL lipid peroxidation. Nitrites 68-75 apolipoprotein B Homo sapiens 148-168 10342784-2 1999 In vitro studies in which intact rat aortic rings were incubated with endotoxin (1 microg/mL) or interferon-gamma (600 U/mL) indicated that the expression of inducible nitric oxide synthase (iNOS) activity was increased as measured by Northern blot analysis or determination of nitrite production. Nitrites 278-285 nitric oxide synthase 2 Rattus norvegicus 158-189 10342784-2 1999 In vitro studies in which intact rat aortic rings were incubated with endotoxin (1 microg/mL) or interferon-gamma (600 U/mL) indicated that the expression of inducible nitric oxide synthase (iNOS) activity was increased as measured by Northern blot analysis or determination of nitrite production. Nitrites 278-285 nitric oxide synthase 2 Rattus norvegicus 191-195 10369455-2 1999 Interleukin 1beta (IL-1beta) induces both enzymes with a similar time course resulting in an increase in nitrite production and sPLA2-IIA activity. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 0-17 10369455-2 1999 Interleukin 1beta (IL-1beta) induces both enzymes with a similar time course resulting in an increase in nitrite production and sPLA2-IIA activity. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 19-27 10410269-10 1999 Stimulation with CM increased nitrite production in 3T3 fibroblasts, which was significantly inhibited by antibodies against interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and iNOS inhibitor, L-NMMA. Nitrites 30-37 interleukin 1 beta Mus musculus 125-143 10410269-10 1999 Stimulation with CM increased nitrite production in 3T3 fibroblasts, which was significantly inhibited by antibodies against interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and iNOS inhibitor, L-NMMA. Nitrites 30-37 interleukin 1 beta Mus musculus 145-154 10410269-10 1999 Stimulation with CM increased nitrite production in 3T3 fibroblasts, which was significantly inhibited by antibodies against interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and iNOS inhibitor, L-NMMA. Nitrites 30-37 tumor necrosis factor Mus musculus 186-195 10215909-4 1999 Neuronal NOS appeared to be activated autonomously and produced NO in culture as monitored by nitrite accumulation. Nitrites 94-101 nitric oxide synthase 1 Rattus norvegicus 0-12 10235127-3 1999 In rats subjected to water immersion restraint stress over a 6-hour period, the concentration of gastric mucosal nitrite/nitrate, breakdown products of NO, increased with the development of gastric mucosal lesions and a decrease in cNOS activity and a drastic increase in iNOS activity in the gastric mucosal tissue. Nitrites 113-120 nitric oxide synthase 2 Rattus norvegicus 272-276 10235127-6 1999 This deteriorative action of postadministration of L-arginine (300 mg/kg intraperitoneally) was prevented by pretreatment with aminoguanidine (100 mg/kg subcutaneously), a selective iNOS inhibitor, with inhibition of increases in gastric mucosal iNOS activity and nitrite/nitrate concentration. Nitrites 264-271 nitric oxide synthase 2 Rattus norvegicus 182-186 10600037-6 1999 VSMC transfected with another plasmid, containing endothelial constitutive NO synthase (ecNOS) cDNA generated micromolar quantities of nitrite. Nitrites 135-142 nitric oxide synthase 3 Homo sapiens 88-93 10208844-6 1999 Treatment of rats with the selective iNOS inhibitor L-iminoethyl-lysine (L-NIL) dramatically reduced NO levels in lavage fluid as measured by decreases in nitrate and nitrite concentrations without significantly affecting iNOS protein levels. Nitrites 167-174 nitric oxide synthase 2 Rattus norvegicus 37-41 10203355-4 1999 (1) Nitrite produced by rat mesangial cells in primary culture was measured in incubations with tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS), with or without IFN-gamma. Nitrites 4-11 tumor necrosis factor Rattus norvegicus 96-123 10203355-4 1999 (1) Nitrite produced by rat mesangial cells in primary culture was measured in incubations with tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS), with or without IFN-gamma. Nitrites 4-11 tumor necrosis factor Rattus norvegicus 125-134 10201946-4 1999 However, inhibition of nitrite accumulation by >/=85% with higher concentrations of L-NMMA shows 1) up-regulation of PGE2 production, 2) accumulation of COX-2 protein in the 100,000 x g soluble and membrane fractions of the cytosolic fraction, and 3) with no significant effects on the accumulation of COX-2 mRNA. Nitrites 23-30 prostaglandin-endoperoxide synthase 2 Mus musculus 156-161 10201946-4 1999 However, inhibition of nitrite accumulation by >/=85% with higher concentrations of L-NMMA shows 1) up-regulation of PGE2 production, 2) accumulation of COX-2 protein in the 100,000 x g soluble and membrane fractions of the cytosolic fraction, and 3) with no significant effects on the accumulation of COX-2 mRNA. Nitrites 23-30 prostaglandin-endoperoxide synthase 2 Mus musculus 305-310 10090833-7 1999 RESULTS: IL-1 beta caused nitrite levels to increase nearly 10-fold over basal levels at 24 h (P < 0.05). Nitrites 26-33 interleukin 1 beta Rattus norvegicus 9-18 10090833-8 1999 Nitrite levels increased with the addition of either db-cAMP (100 microM, an 8-fold increase) or 8-Br-cGMP (100 microM, a 3-fold increase) to IL-1 beta (P < 0.05). Nitrites 0-7 interleukin 1 beta Rattus norvegicus 142-151 10051448-8 1999 Treatment with ITF overnight resulted in a low level of nitrite production by the cells, a 5-fold increase over control, in a concentration-dependent manner. Nitrites 56-63 trefoil factor 3 Rattus norvegicus 15-18 10090667-7 1999 iNOS-positive cells also were immunoreactive for nitrotyrosine, reflecting protein nitration by NO-derived peroxynitrite and nitrites. Nitrites 125-133 nitric oxide synthase 2 Homo sapiens 0-4 10435033-6 1999 Nitrite production by papillary muscles challenged with TNF-alpha alone. Nitrites 0-7 tumor necrosis factor Cavia porcellus 56-65 10435033-12 1999 The role of PAF and NO as mediators of TNF-alpha was suggested by: (1) the protective effect of L-NAME, but not of D-NAME, on electrical and mechanical alterations; (2) the stimulatory effect of TNF-alpha on nitrite production; (3) the inhibitory effect of WEB 2170 and CV 3988, on both the electromechanical alterations and the nitrite production; (4) the synthesis of PAF induced by TNF-alpha. Nitrites 208-215 tumor necrosis factor Cavia porcellus 39-48 10435033-12 1999 The role of PAF and NO as mediators of TNF-alpha was suggested by: (1) the protective effect of L-NAME, but not of D-NAME, on electrical and mechanical alterations; (2) the stimulatory effect of TNF-alpha on nitrite production; (3) the inhibitory effect of WEB 2170 and CV 3988, on both the electromechanical alterations and the nitrite production; (4) the synthesis of PAF induced by TNF-alpha. Nitrites 329-336 tumor necrosis factor Cavia porcellus 39-48 10218656-3 1999 While LPO/H2O2 alone generated only minute amounts of radicals from these compounds, the yield of radicals increased sharply when nitrite was also present. Nitrites 130-137 lactoperoxidase Homo sapiens 6-9 10218656-4 1999 In aerated buffer (pH 7) the nitrite-dependent oxidation of NAD(P)H by LPO/H2O2 produced superoxide radical, O2*-, which was detected as a DMPO/*O2H adduct. Nitrites 29-36 lactoperoxidase Homo sapiens 71-74 10218656-5 1999 We propose that in the LPO/H2O2/NO2-/biological electron donor systems the nitrite functions as a catalyst because of its preferential oxidation by LPO to a strongly oxidizing metabolite, most likely a nitrogen dioxide radical *NO2, which then reacts with the biological substrates more efficiently than does LPO/H2O2 alone. Nitrites 75-82 lactoperoxidase Homo sapiens 23-26 10218656-5 1999 We propose that in the LPO/H2O2/NO2-/biological electron donor systems the nitrite functions as a catalyst because of its preferential oxidation by LPO to a strongly oxidizing metabolite, most likely a nitrogen dioxide radical *NO2, which then reacts with the biological substrates more efficiently than does LPO/H2O2 alone. Nitrites 75-82 lactoperoxidase Homo sapiens 148-151 10218656-5 1999 We propose that in the LPO/H2O2/NO2-/biological electron donor systems the nitrite functions as a catalyst because of its preferential oxidation by LPO to a strongly oxidizing metabolite, most likely a nitrogen dioxide radical *NO2, which then reacts with the biological substrates more efficiently than does LPO/H2O2 alone. Nitrites 75-82 lactoperoxidase Homo sapiens 148-151 10484680-4 1999 Surprisingly, only serum-starved cells showed significant amount of nitrite accumulation and iNOS protein expression in response to IFN-gamma in dose- and time-dependent manners, but serum-supplied cells did not. Nitrites 68-75 interferon gamma Mus musculus 132-141 10076187-3 1999 Treatment with IL-1beta enhanced media accumulation of nitrites (4.8-fold), prostaglandin E2 (PGE2, 3. Nitrites 55-63 interleukin 1 beta Homo sapiens 15-23 10076187-7 1999 However, the addition of TGFbeta1 inhibited IL-1beta-stimulated nitrite (100%), PGE2 (44%) and lactate (78%) accumulation and inhibited IL-1beta-stimulated glucose consumption (74%) in a dose-dependent manner. Nitrites 64-71 transforming growth factor beta 1 Homo sapiens 25-33 10076187-7 1999 However, the addition of TGFbeta1 inhibited IL-1beta-stimulated nitrite (100%), PGE2 (44%) and lactate (78%) accumulation and inhibited IL-1beta-stimulated glucose consumption (74%) in a dose-dependent manner. Nitrites 64-71 interleukin 1 beta Homo sapiens 44-52 10190728-7 1999 In the overall series, a highly significant linear correlation between nitrites/nitrates and vWF:antigen levels was observed in patients with cirrhosis (r=0.79, p<0.001). Nitrites 71-79 von Willebrand factor Homo sapiens 93-96 10193805-5 1999 RESULTS: RHuEpo inhibited IL-1beta-induced nitrite production in a dose- and time-dependent manner with concomitant changes of intracellular cGMP contents. Nitrites 43-50 interleukin 1 beta Rattus norvegicus 26-34 10029554-0 1999 8-Nitro-2"-deoxyguanosine, a specific marker of oxidation by reactive nitrogen species, is generated by the myeloperoxidase-hydrogen peroxide-nitrite system of activated human phagocytes. Nitrites 142-149 myeloperoxidase Homo sapiens 108-123 10205669-0 1999 Roles of nitrate, nitrite and ammonium ion in phytochrome regulation of nitrate reductase gene expression in maize. Nitrites 18-25 nitrate reductase [NADH] 1 Zea mays 72-89 10334319-6 1999 Basal plasma venous concentrations of nitrites/nitrates (NO2- + NO3-) were determined both before and after intravenous insulin infusion. Nitrites 38-46 NBL1, DAN family BMP antagonist Homo sapiens 64-67 10206416-5 1999 Serum nitrite levels in preeclamptic women had significant positive correlations with hematocrit, fasting insulinemia, and apolipoprotein B and negative correlations with platelet count, serum phosphorus and glucose:insulin ratio. Nitrites 6-13 apolipoprotein B Homo sapiens 123-139 10206416-5 1999 Serum nitrite levels in preeclamptic women had significant positive correlations with hematocrit, fasting insulinemia, and apolipoprotein B and negative correlations with platelet count, serum phosphorus and glucose:insulin ratio. Nitrites 6-13 insulin Homo sapiens 106-113 10193578-0 1999 Inactivation of myocardial dihydrolipoamide dehydrogenase by myeloperoxidase systems: effect of halides, nitrite and thiol compounds. Nitrites 105-112 dihydrolipoamide dehydrogenase Equus caballus 27-57 10193578-0 1999 Inactivation of myocardial dihydrolipoamide dehydrogenase by myeloperoxidase systems: effect of halides, nitrite and thiol compounds. Nitrites 105-112 myeloperoxidase Equus caballus 61-76 9878697-2 1999 CsA applied simultaneously with iNOS activator IFN-gamma caused dose-dependent reduction of NO synthesis in confluent C6 cells, as determined by measuring accumulation of nitrite, an indicator of NO production, in 48 h culture supernatants. Nitrites 171-178 nitric oxide synthase 2 Rattus norvegicus 32-36 9878697-2 1999 CsA applied simultaneously with iNOS activator IFN-gamma caused dose-dependent reduction of NO synthesis in confluent C6 cells, as determined by measuring accumulation of nitrite, an indicator of NO production, in 48 h culture supernatants. Nitrites 171-178 interferon gamma Rattus norvegicus 47-56 10433070-6 1999 We found that (1) IL-1beta at 10 U/ml increased nitrite production, inhibited insulin release, increased HSP-70 expression and decreased GAD-65 expression. Nitrites 48-55 interleukin 1 beta Rattus norvegicus 18-26 10437301-7 1999 After interleukin-1 beta stimulation chondrocytes produced great quantities of nitrosothiols and nitrite. Nitrites 97-104 interleukin 1 beta Homo sapiens 6-24 9931117-5 1999 Tested separately, the p38 kinase and MAPK inhibitors partially reduced IL stimulation of nitrite, iNOS protein, and iNOS mRNA; used together, they completely abolished the effect of IL. Nitrites 90-97 mitogen-activated protein kinase 14 Homo sapiens 23-26 10761541-5 1999 However, both IL-1 beta and G-CSF caused a significant increase (p < 0.05) in nitrite levels at 48 h. NG-L-arginine-methyl-ester was used to inhibit nitrite production induced by G-CSF and this implicated nitric oxide synthase activity. Nitrites 81-88 interleukin 1 beta Rattus norvegicus 14-23 10761541-5 1999 However, both IL-1 beta and G-CSF caused a significant increase (p < 0.05) in nitrite levels at 48 h. NG-L-arginine-methyl-ester was used to inhibit nitrite production induced by G-CSF and this implicated nitric oxide synthase activity. Nitrites 81-88 colony stimulating factor 3 Rattus norvegicus 28-33 10761541-5 1999 However, both IL-1 beta and G-CSF caused a significant increase (p < 0.05) in nitrite levels at 48 h. NG-L-arginine-methyl-ester was used to inhibit nitrite production induced by G-CSF and this implicated nitric oxide synthase activity. Nitrites 152-159 interleukin 1 beta Rattus norvegicus 14-23 10761541-5 1999 However, both IL-1 beta and G-CSF caused a significant increase (p < 0.05) in nitrite levels at 48 h. NG-L-arginine-methyl-ester was used to inhibit nitrite production induced by G-CSF and this implicated nitric oxide synthase activity. Nitrites 152-159 colony stimulating factor 3 Rattus norvegicus 28-33 10761541-5 1999 However, both IL-1 beta and G-CSF caused a significant increase (p < 0.05) in nitrite levels at 48 h. NG-L-arginine-methyl-ester was used to inhibit nitrite production induced by G-CSF and this implicated nitric oxide synthase activity. Nitrites 152-159 colony stimulating factor 3 Rattus norvegicus 182-187 10761541-6 1999 When G-CSF and IL-1 beta were used in a combined treatment, nitrite levels were significantly increased (p < 0.05) at both 24 and 48 h. Both IL-3 alone and in combination with IL-1 beta caused elevated PGE2 production in this model. Nitrites 60-67 colony stimulating factor 3 Rattus norvegicus 5-10 10761541-6 1999 When G-CSF and IL-1 beta were used in a combined treatment, nitrite levels were significantly increased (p < 0.05) at both 24 and 48 h. Both IL-3 alone and in combination with IL-1 beta caused elevated PGE2 production in this model. Nitrites 60-67 interleukin 1 beta Rattus norvegicus 15-24 10761541-6 1999 When G-CSF and IL-1 beta were used in a combined treatment, nitrite levels were significantly increased (p < 0.05) at both 24 and 48 h. Both IL-3 alone and in combination with IL-1 beta caused elevated PGE2 production in this model. Nitrites 60-67 interleukin 3 Rattus norvegicus 144-148 10761541-6 1999 When G-CSF and IL-1 beta were used in a combined treatment, nitrite levels were significantly increased (p < 0.05) at both 24 and 48 h. Both IL-3 alone and in combination with IL-1 beta caused elevated PGE2 production in this model. Nitrites 60-67 interleukin 1 beta Rattus norvegicus 179-188 9886494-3 1999 Here we show that human spermatozoa exhibit a detectable NO synthase (NOS) activity, measured both as ability of the intact sperm and cell lysate to convert L-[3H]arginine into L-[3H]citrulline and as 24 h accumulation of extracellular nitrite in intact sperm suspensions. Nitrites 236-243 nitric oxide synthase 2 Homo sapiens 57-68 10534015-4 1999 Gossypol enhanced the nitrite content in culture media of SGC and inhibited basal progesterone secretion by SGC. Nitrites 22-29 sarcoglycan beta Homo sapiens 58-61 9882039-8 1998 Cat"s claw inhibited lipopolysaccharide-induced iNOS gene expression, nitrite formation, cell death and inhibited the activation of NF-kappaB. Nitrites 70-77 nuclear factor kappa B subunit 1 Homo sapiens 132-141 9860503-3 1998 The yield of 3-nitrotyrosine derived from interaction of equimolar nitrite and tyrosine at pH 1 is approximately 50% of that obtained from equimolar peroxynitrite-tyrosine interactions at pH 7. Nitrites 67-74 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 91-95 9792689-10 1998 Pyrrolidinedithiocarbamate (3-30 microM), an inhibitor of NF-kappaB, caused a concentration-dependent reduction in the nitrite response to LPS and UTP. Nitrites 119-126 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 58-67 9877390-6 1998 A human chondrosarcoma was also shown to have an upregulated inducible nitric oxide synthase by both the detection of mRNA for inducible nitric oxide synthase and the presence of nitrites from the culture medium of the tumor in organ culture. Nitrites 179-187 nitric oxide synthase 2 Rattus norvegicus 61-92 9806822-3 1998 Aminoguanidine, a selective inducible NO synthase (iNOS) inhibitor, at a dose of 100 mg kg-1 significantly reduced the LPS-induced increase in nitrite levels and improved mortality. Nitrites 143-150 nitric oxide synthase 2, inducible Mus musculus 28-49 9806822-3 1998 Aminoguanidine, a selective inducible NO synthase (iNOS) inhibitor, at a dose of 100 mg kg-1 significantly reduced the LPS-induced increase in nitrite levels and improved mortality. Nitrites 143-150 nitric oxide synthase 2, inducible Mus musculus 51-55 9806822-4 1998 Econazole, iNOS inhibitor, calmodulin antagonist, 5-lipoxygenase and a specific thromboxane synthase inhibitor, at a 1 mg kg-1 dose significantly decreased the LPS-induced increase in nitrite levels, but increased mortality 4. Nitrites 184-191 nitric oxide synthase 2, inducible Mus musculus 11-15 9806822-4 1998 Econazole, iNOS inhibitor, calmodulin antagonist, 5-lipoxygenase and a specific thromboxane synthase inhibitor, at a 1 mg kg-1 dose significantly decreased the LPS-induced increase in nitrite levels, but increased mortality 4. Nitrites 184-191 calmodulin 2 Mus musculus 27-37 9806822-4 1998 Econazole, iNOS inhibitor, calmodulin antagonist, 5-lipoxygenase and a specific thromboxane synthase inhibitor, at a 1 mg kg-1 dose significantly decreased the LPS-induced increase in nitrite levels, but increased mortality 4. Nitrites 184-191 arachidonate 5-lipoxygenase Mus musculus 50-64 9806822-6 1998 Indomethacin, a putative iNOS and non-selective cyclo-oxygenase (COX) inhibitor, of 1, 10 and 100 mg kg-1, dose dependently decreased the LPS-induced increase in nitrite levels. Nitrites 162-169 nitric oxide synthase 2, inducible Mus musculus 25-29 9811394-9 1998 There are a few studies assessing NO generation in hypertensive children via plasma nitrite and nitrate, the NO end products, which suggest normal or increased production as opposed to a reduction, perhaps as a compensatory phenomenon. Nitrites 84-91 nitric oxide synthase 2 Homo sapiens 34-36 9770329-2 1998 Cross-linking of CD23 by a monoclonal antibody induced iNOS mRNA, as detected by RT-PCR, and the production of NO measured as the stable derivative, nitrite. Nitrites 149-156 Fc epsilon receptor II Homo sapiens 17-21 9770329-4 1998 The iNOS activity reached a maximum 48 h after ligation of CD23, then declined rapidly until 72 h. In parallel, nitrite production was detected after 24 h and reached a maximum after 48 h. In addition, ligation of the CD23 molecule induced, in a time-dependent manner, the production of IL-10. Nitrites 112-119 nitric oxide synthase 2 Homo sapiens 4-8 9770329-4 1998 The iNOS activity reached a maximum 48 h after ligation of CD23, then declined rapidly until 72 h. In parallel, nitrite production was detected after 24 h and reached a maximum after 48 h. In addition, ligation of the CD23 molecule induced, in a time-dependent manner, the production of IL-10. Nitrites 112-119 Fc epsilon receptor II Homo sapiens 218-222 9770329-4 1998 The iNOS activity reached a maximum 48 h after ligation of CD23, then declined rapidly until 72 h. In parallel, nitrite production was detected after 24 h and reached a maximum after 48 h. In addition, ligation of the CD23 molecule induced, in a time-dependent manner, the production of IL-10. Nitrites 112-119 interleukin 10 Homo sapiens 287-292 9770329-6 1998 Furthermore, the addition of exogenous IL-10 suppressed CD23-driven iNOS mRNA expression, iNOS activity and production of nitrite. Nitrites 122-129 interleukin 10 Homo sapiens 39-44 9770329-6 1998 Furthermore, the addition of exogenous IL-10 suppressed CD23-driven iNOS mRNA expression, iNOS activity and production of nitrite. Nitrites 122-129 Fc epsilon receptor II Homo sapiens 56-60 9759915-3 1998 In this study, the effect of activation P2Z/P2X7 receptor was investigated on the bacterial lipopolysaccharide induced nitric oxide production in RAW 264.7 macrophage call line using the nitrite/nitrate assay. Nitrites 187-194 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 44-57 9767607-2 1998 Under these conditions, we were able to detect nitrite in the incubation medium when the eosinophils were stimulated with IFN-gamma or IL-8 in the presence of LPS. Nitrites 47-54 interferon gamma Rattus norvegicus 122-131 9767607-4 1998 Significant levels of nitrite in the medium were already present after 12 h of stimulation and increased steadily within the next 48 h. Regarding NO synthase, its highest activity was achieved at 12 h after IFN-gamma/LPS stimulation. Nitrites 22-29 interferon gamma Rattus norvegicus 207-216 9767607-9 1998 It was observed that these cells were able to produce nitrite and to kill the parasite after activation with LPS/IFN-gamma. Nitrites 54-61 interferon gamma Rattus norvegicus 113-122 9743555-2 1998 Incubation of macrophages with ATIII plus interferon-gamma (IFN-gamma) but not ATIII alone induced nitrite accumulation (a metabolite of NO) in a dose-dependent manner. Nitrites 99-106 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 Mus musculus 31-36 9743555-2 1998 Incubation of macrophages with ATIII plus interferon-gamma (IFN-gamma) but not ATIII alone induced nitrite accumulation (a metabolite of NO) in a dose-dependent manner. Nitrites 99-106 interferon gamma Mus musculus 42-58 9743555-2 1998 Incubation of macrophages with ATIII plus interferon-gamma (IFN-gamma) but not ATIII alone induced nitrite accumulation (a metabolite of NO) in a dose-dependent manner. Nitrites 99-106 interferon gamma Mus musculus 60-69 9716040-9 1998 The intensity of iNOS expression in AM was correlated with the level of exhaled NO (rs = 0.73, n = 76, P< 0.001) and the nitrite released in ELF (rs = 0.56, n = 76, P< 0.001). Nitrites 124-131 nitric oxide synthase 2 Homo sapiens 17-21 9716178-3 1998 In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants. Nitrites 222-229 tumor necrosis factor Homo sapiens 37-64 9716178-3 1998 In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants. Nitrites 222-229 interleukin 1 beta Homo sapiens 81-98 9888514-6 1998 Using the Griess colorimetric assay, we found that Ang II, by its AT2 receptor, induced nitrite formation from NO. Nitrites 88-95 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 51-57 9888514-6 1998 Using the Griess colorimetric assay, we found that Ang II, by its AT2 receptor, induced nitrite formation from NO. Nitrites 88-95 angiotensin II receptor, type 2 Mus musculus 66-78 9723778-2 1998 Incubation of M. bovis BCG-infected macrophages with recombinant bovine IFN-gamma led to increased nitrite levels in culture supernatants. Nitrites 99-106 interferon gamma Bos taurus 72-81 9691088-4 1998 The IL-1 receptor antagonist protein (IRAP) prevents TNF + LPS + IFN-gamma-induced iNOS expression and nitrite production, and attenuates the inhibitory effects on glucose-stimulated insulin secretion by human islets. Nitrites 103-110 interleukin 1 receptor antagonist Homo sapiens 4-36 9691088-4 1998 The IL-1 receptor antagonist protein (IRAP) prevents TNF + LPS + IFN-gamma-induced iNOS expression and nitrite production, and attenuates the inhibitory effects on glucose-stimulated insulin secretion by human islets. Nitrites 103-110 interleukin 1 receptor antagonist Homo sapiens 38-42 9691088-4 1998 The IL-1 receptor antagonist protein (IRAP) prevents TNF + LPS + IFN-gamma-induced iNOS expression and nitrite production, and attenuates the inhibitory effects on glucose-stimulated insulin secretion by human islets. Nitrites 103-110 tumor necrosis factor Homo sapiens 53-56 9691088-4 1998 The IL-1 receptor antagonist protein (IRAP) prevents TNF + LPS + IFN-gamma-induced iNOS expression and nitrite production, and attenuates the inhibitory effects on glucose-stimulated insulin secretion by human islets. Nitrites 103-110 interferon gamma Homo sapiens 65-74 9686606-12 1998 Peroxynitrite alone mediated cross-linking (100 microM ONOO-: 40.3+/-1.9% cross-linking; p < 0.002), and the addition of MPO significantly enhanced this effect (100 microM: 57.7+/-6.0%; p < 0.0002 with respect to no nitrite control). Nitrites 6-13 myeloperoxidase Homo sapiens 124-127 9688317-4 1998 Following immunisation with myelin basic protein (MBP)-complete Freund"s adjuvant (CFA), PVG rats developed higher serum levels of the surrogate markers of nitric oxide production, reactive nitrogen intermediates (RNI; nitrite and nitrate), than did their Lewis counterparts. Nitrites 219-226 myelin basic protein Rattus norvegicus 28-48 9688317-4 1998 Following immunisation with myelin basic protein (MBP)-complete Freund"s adjuvant (CFA), PVG rats developed higher serum levels of the surrogate markers of nitric oxide production, reactive nitrogen intermediates (RNI; nitrite and nitrate), than did their Lewis counterparts. Nitrites 219-226 myelin basic protein Rattus norvegicus 50-53 9667498-6 1998 We propose that the mechanism for the generation of melanin radicals by the LPO/H2O2/nitrite system involves oxidation of NO2- by LPO/H2O2 to a reactive metabolite, most likely the nitrogen dioxide radical (.NO2), which subsequently reacts with melanin 5,6-dihydroxyindole subunits producing the respective semiquinone radicals. Nitrites 85-92 lactoperoxidase Homo sapiens 76-79 9667498-6 1998 We propose that the mechanism for the generation of melanin radicals by the LPO/H2O2/nitrite system involves oxidation of NO2- by LPO/H2O2 to a reactive metabolite, most likely the nitrogen dioxide radical (.NO2), which subsequently reacts with melanin 5,6-dihydroxyindole subunits producing the respective semiquinone radicals. Nitrites 85-92 lactoperoxidase Homo sapiens 130-133 9655731-2 1998 It is produced by nitric oxide synthase (NOS) and is rapidly metabolized to nitrite and nitrate (NO2/NO3). Nitrites 76-83 nitric oxide synthase 2 Homo sapiens 18-39 9655731-2 1998 It is produced by nitric oxide synthase (NOS) and is rapidly metabolized to nitrite and nitrate (NO2/NO3). Nitrites 76-83 NBL1, DAN family BMP antagonist Homo sapiens 101-104 9614147-6 1998 We show that inhibition of NF-kappaB by pyrrolidinedithiocarbamate prevents poly(I-C) + IFN-gamma-, poly(I-C) + LPS-, and LPS-induced iNOS expression, nitrite production and IkappaB degradation by RAW 264.7 cells. Nitrites 151-158 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 27-36 9614147-6 1998 We show that inhibition of NF-kappaB by pyrrolidinedithiocarbamate prevents poly(I-C) + IFN-gamma-, poly(I-C) + LPS-, and LPS-induced iNOS expression, nitrite production and IkappaB degradation by RAW 264.7 cells. Nitrites 151-158 nitric oxide synthase 2, inducible Mus musculus 134-138 9614147-9 1998 In addition, we show that the combination of poly(I-C) + IFN-gamma stimulates iNOS expression, nitrite production, IkappaB degradation, and the release of IL-1 by primary mouse macrophages, and these effects are prevented by pyrrolidinedithiocarbamate. Nitrites 95-102 interferon gamma Mus musculus 57-66 9614147-10 1998 These findings indicate that double-stranded RNA, in the presence of IFN-gamma, is a potent activator of macrophages, stimulating iNOS expression, nitrite production, and IL-1 release by a mechanism which requires the activation of NF-kappaB. Nitrites 147-154 interferon gamma Mus musculus 69-78 9690866-4 1998 Incubation of T 67 astroglial cell line with IL-beta (10 ng ml(-1)) and TNF-alpha (500 u ml(-1)) produced a significant (P<0.05) increase of both nitrite (the breakdown product of NO), cyclic GMP and PGE2 levels in cell supernatants. Nitrites 149-156 tumor necrosis factor Homo sapiens 72-81 9690866-5 1998 N omega-nitro-L-arginine methyl ester (L-NAME; 20-300 microM), an inhibitor of NO synthase (NOS), inhibited the increase of cyclic GMP and nitrite levels found in supernatants of cytokine-treated astroglial cells and reduced the release of PGE2. Nitrites 139-146 nitric oxide synthase 2 Homo sapiens 79-90 9631803-10 1998 IL-10 levels correlated with IL-6 levels (days 1 and 2) and nitrite+nitrate levels (days 1 and 3; p<0.05). Nitrites 60-67 interleukin 10 Homo sapiens 0-5 9610731-7 1998 All IL-10 producing cell lines accumulated uM concentrations of nitrite in response to short term (24 hr) cytokine stimulation. Nitrites 64-71 interleukin 10 Mus musculus 4-9 9607316-0 1998 Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions. Nitrites 64-71 xanthine dehydrogenase Homo sapiens 0-23 9607316-1 1998 Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Nitrites 165-172 xanthine dehydrogenase Homo sapiens 0-23 9607316-1 1998 Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Nitrites 165-172 xanthine dehydrogenase Homo sapiens 25-28 10076538-3 1998 IL-1 beta also increased islet nitrite production, which was antagonized by EA and EA-A, but not by EA-S. Nitrites 31-38 interleukin 1 beta Rattus norvegicus 0-9 9573098-5 1998 When RAW264.7 cells were pretreated with human TNF or TNF(70-80) in the presence of IFN-gamma, there was a dose-dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants. Nitrites 266-273 tumor necrosis factor Homo sapiens 47-50 9573098-5 1998 When RAW264.7 cells were pretreated with human TNF or TNF(70-80) in the presence of IFN-gamma, there was a dose-dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants. Nitrites 266-273 tumor necrosis factor Homo sapiens 54-57 9573098-5 1998 When RAW264.7 cells were pretreated with human TNF or TNF(70-80) in the presence of IFN-gamma, there was a dose-dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants. Nitrites 266-273 interferon gamma Homo sapiens 84-93 9667075-9 1998 The modest enhancement in nitrite accumulation provoked by IGF-I in high glucose conditions was not accompanied by demonstrable increases in iNOS mRNA abundance or protein content. Nitrites 26-33 insulin-like growth factor 1 Rattus norvegicus 59-64 9617881-2 1998 Here we report for the first time that 1400W, a novel and highly selective inhibitor of iNOS activity, attenuates the delayed hypotension as well as the rise in the plasma levels of nitrite/nitrate caused by endotoxin in the rat. Nitrites 182-189 nitric oxide synthase 2 Rattus norvegicus 88-92 9617881-4 1998 Similarly, administration of another selective inhibitor of iNOS activity, L-NIL, 2 h after endotoxin injection abolished the rise in nitrite/nitrate and attenuated the delayed hypotension caused by endotoxin, but failed to ameliorate organ injury. Nitrites 134-141 nitric oxide synthase 2 Rattus norvegicus 60-64 9571172-3 1998 Therefore, we measured nitrite accumulation in cytokine-stimulated, rat mesangial cells (RMC) in response to graded concentrations of VEGF. Nitrites 23-30 vascular endothelial growth factor A Rattus norvegicus 134-138 9581907-4 1998 Expression of iNOS was confirmed by Northern and Western blot analyses, and expression of the functional iNOS protein, i.e., production of nitric oxide (NO), was determined by measuring nitrite accumulation in culture supernatants. Nitrites 186-193 nitric oxide synthase 2 Homo sapiens 105-109 9568691-6 1998 A serine protease inhibitor, Nalpha-P-tosyl-L-lysine chloromethyl ketone (TLCK), and a proteasome complex (26S) inhibitor, MG 132, inhibited IL-1beta-induced nitrite formation, an oxidation product of nitric oxide produced by iNOS, in a concentration-dependent manner, with complete inhibition observed at 100 micromol/l and 10 micromol/l, respectively. Nitrites 158-165 interleukin 1 beta Rattus norvegicus 141-149 9623681-9 1998 Compared to control subjects (29.0+/-4.5 fluorescence intensity (FI)), iNOS expression on AM was upregulated in TB patients (86.3+/-12.5 FI) p<0.001 and the capacity for spontaneous generation of nitrite was enhanced. Nitrites 199-206 nitric oxide synthase 2 Homo sapiens 71-75 9623681-10 1998 Nitrite production was inhibited by N(G)-monomethyl-L-arginine (L-NMMA), a competitive inhibitor of iNOS. Nitrites 0-7 nitric oxide synthase 2 Homo sapiens 100-104 9623681-11 1998 The expression of iNOS on AM was related to the concentration of exhaled NO (r=0.66, p<0.001) and the nitrite generation capacity of AM (r(s)=0.77, p<0.001). Nitrites 105-112 nitric oxide synthase 2 Homo sapiens 18-22 10864883-5 2000 NS-398 (a selective COX-2 inhibitor) reduced LPS plus UTP-elicited iNOS induction and nitrite accumulation, supporting for the positive regulation of iNOS gene expression by endogenous PGE(2). Nitrites 86-93 cytochrome c oxidase II, mitochondrial Mus musculus 20-25 10903806-5 2000 When added together, p38i and MEKi decreased IL-1 beta-induced nitrite production over 24 hours by 60%, but did not affect IL-1 beta-induced manganese superoxide dismutase (MnSOD) mRNA expression. Nitrites 63-70 interleukin 1 beta Rattus norvegicus 45-54 10939618-13 2000 Nitrite prevented HOCl-mediated bacterial killing, inhibition of MPO activity, cellular cytotoxicity and inhibition of TNF-alpha production. Nitrites 0-7 myeloperoxidase Mus musculus 65-68 10939618-13 2000 Nitrite prevented HOCl-mediated bacterial killing, inhibition of MPO activity, cellular cytotoxicity and inhibition of TNF-alpha production. Nitrites 0-7 tumor necrosis factor Mus musculus 119-128 10850643-2 2000 Two reports indicate that the human RBC possesses nitric oxide synthase (NOS) activity-by the accumulation of nitrite across a membraned chamber in one and by the hydrolysis of labeled L-arginine, presumably to labeled L-citrulline, in the other. Nitrites 110-117 nitric oxide synthase 2 Homo sapiens 50-71 10913230-3 2000 The incubation of HPASMC with various concentrations of LPS, IL-1(beta)or TNF(alpha)for 24 h caused a significant increase in nitrite release and PGI(2)production. Nitrites 126-133 interleukin 1 beta Homo sapiens 61-71 10913230-3 2000 The incubation of HPASMC with various concentrations of LPS, IL-1(beta)or TNF(alpha)for 24 h caused a significant increase in nitrite release and PGI(2)production. Nitrites 126-133 tumor necrosis factor Homo sapiens 74-84 10913230-7 2000 Addition of L-NMMA to a medium containing LPS or IL-1(beta)reduced nitrite release and attenuated the stimulatory effect of those agents on PGI(2)production. Nitrites 67-74 interleukin 1 beta Homo sapiens 49-59 10788454-3 2000 Total nitrate and nitrite production was completely abolished in cells from iNOS-deficient animals compared with control cells. Nitrites 18-25 nitric oxide synthase 2, inducible Mus musculus 76-80 10919016-5 2000 Stimulation with IL-1 alpha + TNF-alpha + IFN-alpha induced a significant (P < 0.001) increase of nitrite generation by both human colonic biopsies and HT-29 cells. Nitrites 101-108 interleukin 1 alpha Homo sapiens 17-27 10919016-5 2000 Stimulation with IL-1 alpha + TNF-alpha + IFN-alpha induced a significant (P < 0.001) increase of nitrite generation by both human colonic biopsies and HT-29 cells. Nitrites 101-108 tumor necrosis factor Homo sapiens 30-39 10919016-5 2000 Stimulation with IL-1 alpha + TNF-alpha + IFN-alpha induced a significant (P < 0.001) increase of nitrite generation by both human colonic biopsies and HT-29 cells. Nitrites 101-108 interferon alpha 1 Homo sapiens 42-51 10919016-6 2000 The presence of Interleukin-13 produced a significant (P < 0.001) suppression of the cytokine-induced nitrite generation from both colonic biopsies and HT-29 cells. Nitrites 105-112 interleukin 13 Homo sapiens 16-30 10919016-8 2000 Interleukin-13 has an inhibitory effect on cytokine induced nitrite production in colonic mucosa and could play an anti-inflammatory role in intestinal inflammation. Nitrites 60-67 interleukin 13 Homo sapiens 0-14 10807014-5 2000 The continuous infusion of 4-ABH4 efficiently suppressed the enhanced calcium-dependent/independent NO synthase activities induced by endotoxin in lung homogenates and completely suppressed the increase in plasma nitrite + nitrate caused by endotoxin at 5 h, with no significant difference compared with the L- NMMA treatment. Nitrites 213-220 abhydrolase domain containing 4, N-acyl phospholipase B Rattus norvegicus 29-33 10807014-6 2000 Treatment of RAW264.7 murine macrophages with 4-ABH4 but not with L-NMMA suppressed endotoxin-induced tumor necrosis factor-alpha release by the cells, whereas nitrite in the supernatant decreased in a dose-dependent fashion in both assay systems. Nitrites 160-167 abhydrolase domain containing 4 Mus musculus 48-52 10753947-3 2000 Sequential activation with the cytokines IFN-gamma and either tumor necrosis factor-alpha or interleukin-1beta resulted in the induction of iNOS and production of nitrite (20 nM/min) but failed to elicit nitrosation of extracellular 2,3-diaminonapthalene. Nitrites 163-170 interferon gamma Mus musculus 41-89 10753947-3 2000 Sequential activation with the cytokines IFN-gamma and either tumor necrosis factor-alpha or interleukin-1beta resulted in the induction of iNOS and production of nitrite (20 nM/min) but failed to elicit nitrosation of extracellular 2,3-diaminonapthalene. Nitrites 163-170 interleukin 1 beta Mus musculus 93-110 10753947-4 2000 Stimulation with IFN-gamma and bacterial lipopolysaccharide increased the relative level of iNOS protein and nitrite production of ANA-1 cells 2-fold; however, a substantial level of NO in the media was also observed, and nitrosation of 2,3-diaminonapthalene was increased greater than 30-fold. Nitrites 109-116 interferon gamma Mus musculus 17-26 10779013-3 2000 The NOS-2 activity, assessed by nitrite accumulation, was absent from untreated cultures but was induced by interleukin-1beta and interferon-gamma acting synergistically. Nitrites 32-39 nitric oxide synthase 2 Homo sapiens 4-9 10779013-3 2000 The NOS-2 activity, assessed by nitrite accumulation, was absent from untreated cultures but was induced by interleukin-1beta and interferon-gamma acting synergistically. Nitrites 32-39 interleukin 1 beta Homo sapiens 108-125 10779013-3 2000 The NOS-2 activity, assessed by nitrite accumulation, was absent from untreated cultures but was induced by interleukin-1beta and interferon-gamma acting synergistically. Nitrites 32-39 interferon gamma Homo sapiens 130-146 10835296-4 2000 Our results demonstrate that PBN cotreatment prevents the generation of nitrite by RIN-5F cells induced by treatment with tumor necrosis factor-alpha, interleukin 1beta, and interferon-gamma in a dose-dependent fashion. Nitrites 72-79 tumor necrosis factor Mus musculus 122-149 10835296-4 2000 Our results demonstrate that PBN cotreatment prevents the generation of nitrite by RIN-5F cells induced by treatment with tumor necrosis factor-alpha, interleukin 1beta, and interferon-gamma in a dose-dependent fashion. Nitrites 72-79 interleukin 1 beta Mus musculus 151-168 10835296-4 2000 Our results demonstrate that PBN cotreatment prevents the generation of nitrite by RIN-5F cells induced by treatment with tumor necrosis factor-alpha, interleukin 1beta, and interferon-gamma in a dose-dependent fashion. Nitrites 72-79 interferon gamma Mus musculus 174-190 10835296-6 2000 Aminoguanidine, a selective inhibitor of inducible nitric oxide synthase (iNOS), abolished the cytokine-induced nitrite generation whereas N-nitro-l-arginine, an inhibitor more selective for other NOS isoforms, was significantly less effective. Nitrites 112-119 nitric oxide synthase 2 Rattus norvegicus 41-72 10835296-6 2000 Aminoguanidine, a selective inhibitor of inducible nitric oxide synthase (iNOS), abolished the cytokine-induced nitrite generation whereas N-nitro-l-arginine, an inhibitor more selective for other NOS isoforms, was significantly less effective. Nitrites 112-119 nitric oxide synthase 2 Rattus norvegicus 74-78 10713108-4 2000 We find that in Abeta-stimulated astrocyte cultures, IL-1beta and TNFalpha production occur before iNOS production, new protein synthesis is required for increased iNOS mRNA levels, and the IL-1 receptor antagonist IL-1ra can inhibit nitrite accumulation. Nitrites 234-241 amyloid beta precursor protein Homo sapiens 16-21 10758772-0 2000 Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats. Nitrites 79-86 interleukin 6 Rattus norvegicus 40-53 10758772-2 2000 This infusion with IL-6 also increased the levels of nitrite and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) in rat hippocampus. Nitrites 53-60 interleukin 6 Rattus norvegicus 19-23 10705297-3 2000 IFN-gamma, TNF-alpha and IL-10 have been shown to be involved in the regulation of LPS-induced serum levels of the NO-oxidation products nitrate and nitrite. Nitrites 149-156 interferon gamma Mus musculus 0-9 10772174-7 2000 The limits of detection for nitrite and nitrate ions are 1 and 10 mg/kg, respectively. Nitrites 28-35 VPS52 subunit of GARP complex Homo sapiens 53-65 10683447-2 2000 Electrochemical and fluorometric measurements both showed that NO is produced by corn NR in the presence of nitrite and NADH at pH 7. Nitrites 108-115 nitrate reductase [NADH] 1 Zea mays 86-88 10642561-7 2000 Analysis of the culture supernatant demonstrated that the nitrite concentration was 1) proportional to the number of cultured trophoblast cells, 2) almost completely abolished in the presence of N(omega)-nitro-L-arginine methyl ester, and 3) increased 2-fold in cultures stimulated with gamma-interferon. Nitrites 58-65 interferon gamma Mus musculus 287-303 10686080-8 2000 Changes in nNOS expression were accompanied by an increase in cellular cGMP and medium nitrite levels. Nitrites 87-94 nitric oxide synthase 1 Homo sapiens 11-15 10665933-5 2000 Glomerular nitrite production by isolated cultured glomeruli was reduced after IL-10 treatment in vivo (high dose: 2.3 +/- 2.3 nmol/10(4) glomeruli per 72 h; low dose: 28 +/- 5 nmol/10(4) glomeruli per 72 h; control treatment: 82 +/- 11 nmol/10(4) glomeruli per 72 h). Nitrites 11-18 interleukin 10 Rattus norvegicus 79-84 10646512-5 2000 The inhibitory effects of Ang II on lipopolysaccharide-induced expression of iNOS mRNA and protein and nitrite accumulation were mimicked by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate. Nitrites 103-110 angiotensinogen Rattus norvegicus 26-32 10646512-6 2000 Down-regulation of PKC produced by long-term treatment of astroglia with phorbol 12-myristate 13-acetate abolished the inhibitory effect of Ang II on lipopolysaccharide-stimulated expression of iNOS mRNA and nitrite accumulation. Nitrites 208-215 angiotensinogen Rattus norvegicus 140-146 10646512-7 2000 Finally, the reduction of lipopolysaccharide-induced nitrite accumulation by Ang II was attenuated by the selective PKC inhibitor chelerythrine. Nitrites 53-60 angiotensinogen Rattus norvegicus 77-83 10722808-3 2000 Incubation of the cultures with interleukin 1 beta (IL-1 beta; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 101-108 interleukin 1 beta Rattus norvegicus 32-50 10722808-3 2000 Incubation of the cultures with interleukin 1 beta (IL-1 beta; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 101-108 interleukin 1 beta Rattus norvegicus 52-61 10722808-4 2000 Although carvedilol alone showed no effect on nitrite accumulation, it significantly enhanced IL-1 beta-induced nitrite production by cardiac myocytes. Nitrites 112-119 interleukin 1 beta Rattus norvegicus 94-103 10722808-6 2000 The nitrite production enhanced by carvedilol was accompanied by increased iNOS protein expression. Nitrites 4-11 nitric oxide synthase 2 Rattus norvegicus 75-79 10722808-8 2000 Addition of isoproterenol significantly increased nitrite production by IL-1 beta-stimulated cardiac myocytes. Nitrites 50-57 interleukin 1 beta Rattus norvegicus 72-81 11213481-2 2000 Our previous studies indicate that nitrite production is associated with the expression of inducible nitric oxide synthase (iNOS) and reflects NO production. Nitrites 35-42 nitric oxide synthase 2 Rattus norvegicus 91-122 11213481-2 2000 Our previous studies indicate that nitrite production is associated with the expression of inducible nitric oxide synthase (iNOS) and reflects NO production. Nitrites 35-42 nitric oxide synthase 2 Rattus norvegicus 124-128 11213481-7 2000 This reduction in nitrite production by EMS added at 3 hr may be due to the direct modification of thiol groups on the iNOS protein because we have determined that iNOS activity is inhibited by the sulfhydryl modifying reagent N-ethylmaleimide (NEM). Nitrites 18-25 nitric oxide synthase 2 Rattus norvegicus 119-123 11213481-7 2000 This reduction in nitrite production by EMS added at 3 hr may be due to the direct modification of thiol groups on the iNOS protein because we have determined that iNOS activity is inhibited by the sulfhydryl modifying reagent N-ethylmaleimide (NEM). Nitrites 18-25 nitric oxide synthase 2 Rattus norvegicus 164-168 10642306-5 2000 For this, we measured IL-1beta-stimulated nitrite (NOx) production with use of the Griess reagent, prostaglandin E(2) (PGE(2)) production with use of an enzyme immunoassay, and arachidonic acid release in the presence and absence of BEL. Nitrites 42-49 interleukin 1 beta Homo sapiens 22-30 10855945-5 2000 Nitrite production, an indicator of NO synthesis, was measured in the supernatant of rat macrophages whose inducible NO synthase (NOS II, iNOS) had been stimulated by the addition of S. enteritidis lipopolysaccharide (LPS, 50 microg/ml). Nitrites 0-7 nitric oxide synthase 2 Rattus norvegicus 138-142 10631272-5 2000 In addition, the NR mutants were used to study nitrate transporters from nitrite excretion. Nitrites 73-80 uncharacterized protein Chlamydomonas reinhardtii 17-19 10631272-7 2000 A double mutant, deficient in both the high-affinity nitrate transporter genes and NR, excreted nitrite at high CO(2) only when nitrate was present at mM concentrations. Nitrites 96-103 uncharacterized protein Chlamydomonas reinhardtii 83-85 11112001-18 2000 In addition, CS nitrite levels correlated with CS TNF-alpha levels in patients with impaired CFVR (r = 0.44, P = 0.003). Nitrites 16-23 tumor necrosis factor Homo sapiens 50-59 10585458-1 1999 Fully and partially reduced forms of isolated bovine cytochrome c oxidase undergo a two-electron oxidation-reduction process with added peroxynitrite, leading to catalytic oxidation of ferrocytochrome c to ferricytochrome c. The other major reaction product is nitrite ion, 86% of the added peroxynitrite being measurably converted to this species. Nitrites 142-149 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 53-73 10600756-3 1999 The tyrosine kinase inhibitor genistein decreased LPS- and GM-CSF-induced nitrite (NO(-2)) production. Nitrites 74-81 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 59-65 10600449-6 1999 Further, PTN + PLK-infected mice showed higher production of TNF-alpha and nitrite compared to PLK-infected mice. Nitrites 75-82 pleiotrophin Mus musculus 9-12 10600449-6 1999 Further, PTN + PLK-infected mice showed higher production of TNF-alpha and nitrite compared to PLK-infected mice. Nitrites 75-82 polo like kinase 1 Mus musculus 15-18 10582584-2 1999 After 24 h of PRL (5-100 nM) stimulation, a concentration-dependent increase of NO release, evaluated as nitrite, was observed in C6 culture medium. Nitrites 105-112 prolactin Rattus norvegicus 14-17 10630109-4 1999 To obtain first information regarding the molecular targets which might be affected by this constituent, two in vitro bioassays were performed: (i) DNA binding activity of the transcription factor NF-kappa B was evaluated by electrophoretic mobility shift assay (EMSA) using TNF-alpha-activated Jurkat T cells and (ii) nitrite accumulation in cell culture supernatants of LPS-activated RAW 264.7 macrophages was determined as a parameter for inducible nitric oxide synthase (iNOS)-dependent nitric oxide release. Nitrites 319-326 nuclear factor kappa B subunit 1 Homo sapiens 197-207 10563648-2 1999 Patients with MS with an active disease course exhibited increased CSF nitrite levels compared with patients with stable MS and healthy control subjects, whereas CSF nitrate levels did not differ between these groups. Nitrites 71-78 colony stimulating factor 2 Homo sapiens 67-70 10563648-4 1999 These data indicate that CSF nitrite levels may reflect clinical disease activity in MS. Nitrites 29-36 colony stimulating factor 2 Homo sapiens 25-28 10564099-5 1999 ET-1 caused a 2.5-fold increase in eNOS protein in BPAECs, inhibitable with an endothelin B receptor antagonist, and an increase in eNOS mRNA and nitrite production. Nitrites 146-153 endothelin 1 Rattus norvegicus 0-4 10559846-6 1999 Thus, LPS-induced nitrite levels are easily detectable, although lower than those detected only with antigenic stimulation. Nitrites 18-25 toll-like receptor 4 Mus musculus 6-9 10559846-7 1999 Concomitant addition of LPS and L-N-arginine methyl ester (L-NAME) restored the ability to produce detectable levels of nitrite, which had been lost with L-NAME treatment. Nitrites 120-127 toll-like receptor 4 Mus musculus 24-27 10540190-4 1999 Synthesis of nitrite, IL-6 and IL-10 was maximal upon combined stimulation with LPS + IFN-gamma, whereas lower amounts of the three mediators were detected when both stimuli were given alone. Nitrites 13-20 interferon gamma Mus musculus 86-95 10541285-8 1999 Similarly, cilazaprilat elicited greater bradykinin-dependent increases of nitrite/nitrate in the medulla. Nitrites 75-82 kininogen 1 Canis lupus familiaris 41-51 10515827-4 1999 In contrast, higher levels of IL-6, IL-10, and MCP-1 in plasma and higher levels of IL-12, interferon (IFN)-gamma, and nitrite/nitrate were found in all compartments of TNF/Lt-alpha-deficient mice. Nitrites 119-126 tumor necrosis factor Mus musculus 169-172 10515827-5 1999 These data confirm that TNF or Lt-alpha is a key cytokine for the anticryptococcal response and demonstrate its major role for the induction of IL-1beta, IL-6, and KC in the brain; however, its presence is not a prerequisite for IL-12, IFN-gamma, and nitrite/nitrate production. Nitrites 251-258 tumor necrosis factor Mus musculus 24-27 10515827-5 1999 These data confirm that TNF or Lt-alpha is a key cytokine for the anticryptococcal response and demonstrate its major role for the induction of IL-1beta, IL-6, and KC in the brain; however, its presence is not a prerequisite for IL-12, IFN-gamma, and nitrite/nitrate production. Nitrites 251-258 lymphotoxin A Mus musculus 31-39 10645729-4 1999 ARS levels were very low in cells grown in the presence of NH4Cl and dramatically increased on agar medium deprived of any nitrogen source or containing nitrate, nitrite, urea, arginine or glutamine. Nitrites 162-169 uncharacterized protein Chlamydomonas reinhardtii 0-3 10645729-5 1999 Compared to nitrogen-free medium, a slight positive effect of nitrate in the NR+ strain and a significant negative effect of nitrite in both NR+ and NR- strains were observed. Nitrites 125-132 uncharacterized protein Chlamydomonas reinhardtii 141-143 10645729-5 1999 Compared to nitrogen-free medium, a slight positive effect of nitrate in the NR+ strain and a significant negative effect of nitrite in both NR+ and NR- strains were observed. Nitrites 125-132 uncharacterized protein Chlamydomonas reinhardtii 141-143 10506184-4 1999 However, a 30-60-min pulse of rat islets with IFN-gamma, followed by washing to remove the cytokine and continued culture with 0.1 unit/ml IL-1 for 40 h, results in iNOS expression and nitrite production to levels similar in magnitude to the individual effects of 1.0 unit/ml IL-1. Nitrites 185-192 interferon gamma Rattus norvegicus 46-55 10506184-6 1999 IFN-gamma also primes for IL-1-induced iNOS expression and nitrite formation by NOD mouse islets. Nitrites 59-66 interferon gamma Mus musculus 0-9 10506184-7 1999 The priming actions of IFN-gamma appear to be selective for beta-cells, as IFN-gamma primes for IL-1-induced nitrite formation by primary beta-cells and RINm5F insulinoma cells, but not primary alpha-cells. Nitrites 109-116 interferon gamma Rattus norvegicus 23-32 10506184-7 1999 The priming actions of IFN-gamma appear to be selective for beta-cells, as IFN-gamma primes for IL-1-induced nitrite formation by primary beta-cells and RINm5F insulinoma cells, but not primary alpha-cells. Nitrites 109-116 interferon gamma Rattus norvegicus 75-84 10523329-7 1999 Nitrite accumulation was higher by the cells treated with interleukin-1beta combined with either interferon-gamma or tumor necrosis factor-alpha compared with those treated with interleukin-1beta alone. Nitrites 0-7 interleukin 1 beta Rattus norvegicus 58-75 10523329-7 1999 Nitrite accumulation was higher by the cells treated with interleukin-1beta combined with either interferon-gamma or tumor necrosis factor-alpha compared with those treated with interleukin-1beta alone. Nitrites 0-7 interferon gamma Rattus norvegicus 97-144 10523329-7 1999 Nitrite accumulation was higher by the cells treated with interleukin-1beta combined with either interferon-gamma or tumor necrosis factor-alpha compared with those treated with interleukin-1beta alone. Nitrites 0-7 interleukin 1 beta Rattus norvegicus 178-195 10523329-8 1999 N-Acetyl-L-cysteine upregulated nitrite production and inducible nitric oxide synthase expression induced by combination treatment with interleukin-1beta and either interferon-gamma or tumor necrosis factor-alpha. Nitrites 32-39 interleukin 1 beta Rattus norvegicus 136-153 10490919-7 1999 The survival rate to endotoxin in mice was significantly (P <.01) increased by the presence of higenamine in the LPS-treated group up to 48 h. Serum nitrite/nitrate levels were significantly (P <.05) reduced by higenamine in LPS-treated rats. Nitrites 152-159 toll-like receptor 4 Mus musculus 116-119 10464338-5 1999 We now demonstrate that EPO readily uses nitrite (NO(2)(-)), a major end-product of nitric oxide ((. Nitrites 41-48 eosinophil peroxidase Homo sapiens 24-27 10510443-3 1999 Cyclosporin A and FK506 (at 1 microM) also significantly inhibited nitrite production induced by recombinant murine interferon-gamma (rIFNgamma) and recombinant murine interleukin-1beta (rIL-1beta) in J774 and VSMC, respectively. Nitrites 67-74 interferon gamma Mus musculus 116-132 10510443-3 1999 Cyclosporin A and FK506 (at 1 microM) also significantly inhibited nitrite production induced by recombinant murine interferon-gamma (rIFNgamma) and recombinant murine interleukin-1beta (rIL-1beta) in J774 and VSMC, respectively. Nitrites 67-74 interleukin 1 beta Mus musculus 168-185 10510443-3 1999 Cyclosporin A and FK506 (at 1 microM) also significantly inhibited nitrite production induced by recombinant murine interferon-gamma (rIFNgamma) and recombinant murine interleukin-1beta (rIL-1beta) in J774 and VSMC, respectively. Nitrites 67-74 interleukin 1 beta Rattus norvegicus 187-196 10744866-0 1999 An indigenously developed nitrite kit to aid in the diagnosis of urinary tract infection. Nitrites 26-33 activation induced cytidine deaminase Homo sapiens 41-44 10476793-10 1999 Treatment with IL-13 decreased nitrite levels in aqueous humor and enhanced the expression of tumor necrosis factor-alpha (TNF-alpha) and IL-6 mRNA in ocular tissues. Nitrites 31-38 interleukin 13 Rattus norvegicus 15-20 10476793-11 1999 CONCLUSIONS: Interleukin-13 treatment inhibits LPS-induced ocular inflammation with inhibition of nitrite release and increased TNF and IL-6 production in the eye. Nitrites 98-105 interleukin 13 Rattus norvegicus 13-27 10485617-4 1999 The vascular expression of bNOS as well as that of ecNOS was decreased along with tissue nitrite/nitrate contents in DOCA-salt and 2K1C hypertension. Nitrites 89-96 nitric oxide synthase 1 Rattus norvegicus 27-31 10485617-5 1999 The expression of both bNOS and ecNOS was increased in SHR with concomitant changes of tissue nitrite/nitrate contents. Nitrites 94-101 nitric oxide synthase 1 Rattus norvegicus 23-27 10485617-5 1999 The expression of both bNOS and ecNOS was increased in SHR with concomitant changes of tissue nitrite/nitrate contents. Nitrites 94-101 nitric oxide synthase 3 Rattus norvegicus 32-37 10432387-4 1999 METHODS: Expression of iNOS was evaluated by NO production (nitrite analysis), protein (Western blot analysis) and mRNA (RT-PCR analysis) levels in mesangial cells stimulated by a combination of lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) in the presence and absence of all-trans-retinoic acid (ATRA) or its active metabolite, 13-cis-retinoic acid (13-cis-RA). Nitrites 60-67 nitric oxide synthase 2, inducible Mus musculus 23-27 10385647-6 1999 The induction of HBP23 mRNA expression by LPS was preceded by that of the inducible nitric oxide synthase (iNOS) and the production of nitrite in KC. Nitrites 135-142 peroxiredoxin 1 Rattus norvegicus 17-22 10411000-3 1999 Incubation of fMLP-activated neutrophils with OH-L-Arg resulted in a production of nitrite, nitrate, and citrulline that was greater than with unstimulated neutrophils but was not inhibited by the NOS inhibitors L-NMMA and L-NIO or the cytochrome P450 inhibitor troleandomycin and was not seen when OH-L-Arg was replaced with L-Arg. Nitrites 83-90 formyl peptide receptor 1 Homo sapiens 14-18 10407321-6 1999 By using this "reaction continuous-flow mass spectrometry" (R/CFMS) we developed methods for the (15)N determination of nitrite and nitrate from tracer experiment samples, i.e. artificially enriched in (15)N. Because both methods are based on the same principle, one continuous flow setup connected directly to a quadrupole mass spectrometer for all determinations was used. Nitrites 120-127 colony stimulating factor 1 receptor Homo sapiens 62-66 10433499-4 1999 In rat bone marrow derived macrophages 15 nM activin A caused the stimulation of prostaglandin (PG) E2 and thromboxane (TX) A2 formation, production of nitrite as a marker for nitric oxide (NO) and the release of the cytokines tumour necrosis factor (TNF) alpha and interleukin (IL) -1beta. Nitrites 152-159 inhibin subunit beta A Rattus norvegicus 45-54 10433499-10 1999 In contrast to the nitrite production activin A induced PGE2 synthesis was susceptible to tyrosine kinase inhibition by genistein and tyrphostin 46 (IC50 was 10 and 20 microM, respectively). Nitrites 19-26 inhibin subunit beta A Rattus norvegicus 38-47 10437653-5 1999 In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol. Nitrites 244-251 colony stimulating factor 3 Homo sapiens 35-40 10437653-5 1999 In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol. Nitrites 244-251 interferon gamma Homo sapiens 65-74 10380907-3 1999 We also investigated SP-induced formation of nitrite and nitrate as an index of nitric oxide (NO) production. Nitrites 45-52 tachykinin precursor 1 Homo sapiens 21-23 10330425-13 1999 12-LO KO macrophages generated 50% less nitrate/nitrite when compared with C57BL/6 macrophages. Nitrites 48-55 arachidonate 15-lipoxygenase Mus musculus 0-5 10385249-9 1999 Rh-EPO (25, 50 and 100 U 100 g(-1), 5 min following the onset of reperfusion) increased survival rate (70% at 4 h of reperfusion with the highest dose), reduced plasma nitrite/nitrate concentrations (10.3+/-3.3 microM), increased MAP, did not change RBC count and blood Hb, and inhibited iNOS activity in thoracic aortae. Nitrites 168-175 erythropoietin Rattus norvegicus 3-6 10218970-4 1999 Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively. Nitrites 86-94 interleukin 1 beta Rattus norvegicus 5-27 10218970-4 1999 Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively. Nitrites 86-94 tumor necrosis factor Rattus norvegicus 32-65 10329044-7 1999 There was accumulation of nitrite in the culture medium of IFN-gamma-treated cells, suggesting the generation of NOx. Nitrites 26-33 interferon gamma Homo sapiens 59-68 10447723-1 1999 Both the nitrite and prostaglandin E2 (PGE2) release caused by lipopolysaccharide (LPS) in J774 macrophages are inhibited by SB 203580, a specific p38 mitogen-activated protein kinase (MAPK) inhibitor, in a concentration-dependent manner. Nitrites 9-16 mitogen-activated protein kinase 14 Homo sapiens 147-150 10231435-9 1999 The combination of the LPS/IFN-gamma mixture induced iNOS expression and NO production in murine mesangial cells, as assessed by Western blot analysis and measurement of nitrite levels. Nitrites 170-177 toll-like receptor 4 Mus musculus 23-26 10231435-9 1999 The combination of the LPS/IFN-gamma mixture induced iNOS expression and NO production in murine mesangial cells, as assessed by Western blot analysis and measurement of nitrite levels. Nitrites 170-177 interferon gamma Mus musculus 27-36 10231435-9 1999 The combination of the LPS/IFN-gamma mixture induced iNOS expression and NO production in murine mesangial cells, as assessed by Western blot analysis and measurement of nitrite levels. Nitrites 170-177 nitric oxide synthase 2, inducible Mus musculus 53-57 10328994-1 1999 Treatment of rat aortic smooth muscle cells (RASMC) with 1 or 100 microg ml-1 lipopolysaccharide (LPS) for 20-24 h led to expression of the inducible form of nitric oxide synthase (iNOS) as detected by Western blotting for iNOS protein, and by determination of increased cellular nitrite formation. Nitrites 280-287 nitric oxide synthase 2 Rattus norvegicus 181-185 10328994-8 1999 The ability of PDTC and TPCK to abolish LPS-specific NF-kappaB activation, while also producing considerable inhibition of iNOS protein expression and nitrite formation, suggests that induction of iNOS by LPS in RASMC involves NF-kappaB-dependent transcription. Nitrites 151-158 nitric oxide synthase 2 Rattus norvegicus 197-201 10212230-3 1999 Treatment of rat islets with poly(IC) + interferon-gamma (IFN-gamma) stimulates the time- and concentration-dependent expression of iNOS and production of nitrite by rat islets. Nitrites 155-162 interferon gamma Rattus norvegicus 40-56 10212230-3 1999 Treatment of rat islets with poly(IC) + interferon-gamma (IFN-gamma) stimulates the time- and concentration-dependent expression of iNOS and production of nitrite by rat islets. Nitrites 155-162 interferon gamma Rattus norvegicus 58-67 10212230-4 1999 iNOS expression and nitrite production by rat islets in response to poly(IC) + IFN-gamma correlate with an inhibition of insulin secretion and islet degeneration, effects that are prevented by the iNOS inhibitor aminoguanidine (AG). Nitrites 20-27 interferon gamma Rattus norvegicus 79-88 10212230-4 1999 iNOS expression and nitrite production by rat islets in response to poly(IC) + IFN-gamma correlate with an inhibition of insulin secretion and islet degeneration, effects that are prevented by the iNOS inhibitor aminoguanidine (AG). Nitrites 20-27 nitric oxide synthase 2 Rattus norvegicus 197-201 10212230-8 1999 Treatment of macrophage-depleted rat islets for 40 h with poly(IC) + IFN-gamma results in the expression of iNOS, production of nitrite, and inhibition of insulin secretion. Nitrites 128-135 interferon gamma Rattus norvegicus 69-78 10198363-7 1999 There was a correlation between the endotoxin content of the SP-A and SP-D preparations and their ability to stimulate production of nitrite by alveolar macrophages. Nitrites 133-140 surfactant protein A1 Rattus norvegicus 61-65 10198363-7 1999 There was a correlation between the endotoxin content of the SP-A and SP-D preparations and their ability to stimulate production of nitrite by alveolar macrophages. Nitrites 133-140 surfactant protein D Rattus norvegicus 70-74 10102685-3 1999 Exposure of islets isolated from C57BL/6 mice to IL-1beta for 24 h in vitro resulted in an induction of iNOS mRNA expression, an increase in nitrite formation, and a decrease in insulin release and proinsulin biosynthesis as compared with untreated C57BL/6 islets. Nitrites 141-148 interleukin 1 beta Mus musculus 49-57 10203355-9 1999 TNF-alpha or LPS alone did not induce nitrite production, but with IFN-gamma these compounds did induce nitrite production. Nitrites 104-111 interferon gamma Rattus norvegicus 67-76 10203355-14 1999 It can be concluded that (1) iNOS can be induced without active NF-kappaB; (2) Dex, acetylsalicylic acid, and PDTC inhibit only p65; and (3) JAK2 is involved in iNOS induction, and the contribution of JAK2 to nitrite production is greater than that of NF-kappaB. Nitrites 209-216 Janus kinase 2 Rattus norvegicus 141-145 10203355-14 1999 It can be concluded that (1) iNOS can be induced without active NF-kappaB; (2) Dex, acetylsalicylic acid, and PDTC inhibit only p65; and (3) JAK2 is involved in iNOS induction, and the contribution of JAK2 to nitrite production is greater than that of NF-kappaB. Nitrites 209-216 nitric oxide synthase 2 Rattus norvegicus 161-165 10200991-7 1999 RESULTS: Angiotensin II and TGF-beta significantly decreased IL-1 beta-stimulated nitrite accumulation. Nitrites 82-89 angiotensinogen Rattus norvegicus 9-23 10200991-7 1999 RESULTS: Angiotensin II and TGF-beta significantly decreased IL-1 beta-stimulated nitrite accumulation. Nitrites 82-89 transforming growth factor, beta 1 Rattus norvegicus 28-36 10200991-7 1999 RESULTS: Angiotensin II and TGF-beta significantly decreased IL-1 beta-stimulated nitrite accumulation. Nitrites 82-89 interleukin 1 beta Rattus norvegicus 61-70 10069792-5 1999 The IL-1beta-induced nitrite production by VSMCs was significantly increased by homocysteine in a dose-dependent manner. Nitrites 21-28 interleukin 1 beta Rattus norvegicus 4-12 10069792-8 1999 Cysteine, glutathione, or hydrogen peroxide also increased nitrite accumulation in IL-1beta-stimulated VSMCs. Nitrites 59-66 interleukin 1 beta Rattus norvegicus 83-91 10070167-3 1999 AVP inhibited lipopolysaccharide (LPS)- and interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner, with concomitant changes in cGMP content, iNOS mRNA, and iNOS protein. Nitrites 81-88 arginine vasopressin Rattus norvegicus 0-3 10070167-3 1999 AVP inhibited lipopolysaccharide (LPS)- and interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner, with concomitant changes in cGMP content, iNOS mRNA, and iNOS protein. Nitrites 81-88 interleukin 1 beta Rattus norvegicus 44-61 10070167-3 1999 AVP inhibited lipopolysaccharide (LPS)- and interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner, with concomitant changes in cGMP content, iNOS mRNA, and iNOS protein. Nitrites 81-88 interleukin 1 beta Rattus norvegicus 63-71 10218656-0 1999 Oxidation of biological electron donors and antioxidants by a reactive lactoperoxidase metabolite from nitrite (NO2-): an EPR and spin trapping study. Nitrites 103-110 lactoperoxidase Homo sapiens 71-86 10218656-1 1999 We report that a lactoperoxidase (LPO) metabolite derived from nitrite (NO2-) catalyses one-electron oxidation of biological electron donors and antioxidants such as NADH, NADPH, cysteine, glutathione, ascorbate, and Trolox C. Nitrites 63-70 lactoperoxidase Homo sapiens 17-32 10218656-1 1999 We report that a lactoperoxidase (LPO) metabolite derived from nitrite (NO2-) catalyses one-electron oxidation of biological electron donors and antioxidants such as NADH, NADPH, cysteine, glutathione, ascorbate, and Trolox C. Nitrites 63-70 lactoperoxidase Homo sapiens 34-37 10198566-5 1999 RESULTS: Addition of the FSGS factor to cultured RMC led to a significant inhibition of nitrite accumulation, an index of NO synthesis. Nitrites 88-95 actinin alpha 4 Homo sapiens 25-29 10079054-2 1999 The decrease in NO, as demonstrated by measurement of nitrite was found to correlate well with a decrease in inducible nitric oxide synthase (iNOS) mRNA. Nitrites 54-61 nitric oxide synthase 2, inducible Mus musculus 109-140 10079054-2 1999 The decrease in NO, as demonstrated by measurement of nitrite was found to correlate well with a decrease in inducible nitric oxide synthase (iNOS) mRNA. Nitrites 54-61 nitric oxide synthase 2, inducible Mus musculus 142-146 10205669-6 1999 The products of nitrate reduction i.e., nitrite and ammonium ion had inhibitory and stimulatory effects respectively, on NR transcript accumulation. Nitrites 40-47 nitrate reductase [NADH] 1 Zea mays 121-123 10063925-6 1999 Adrenomedullin levels had significant correlations with aldosterone (r = 0.55; P < 0.001), plasma renin activity (r = 0.49; P < 0.001) and nitrates-nitrites levels (r = 0.52; P < 0.001). Nitrites 154-162 adrenomedullin Homo sapiens 0-14 10193578-1 1999 Dihydrolipoamide dehydrogenase (LADH) lipoamide reductase activity decreased whereas enzyme diaphorase activity increased after LADH treatment with myeloperoxidase (MPO) dependent systems (MPO/H2O2/halide, MPO/NADH/halide and MPO/H2O2/nitrite systems. Nitrites 235-242 myeloperoxidase Equus caballus 148-163 10193578-1 1999 Dihydrolipoamide dehydrogenase (LADH) lipoamide reductase activity decreased whereas enzyme diaphorase activity increased after LADH treatment with myeloperoxidase (MPO) dependent systems (MPO/H2O2/halide, MPO/NADH/halide and MPO/H2O2/nitrite systems. Nitrites 235-242 myeloperoxidase Equus caballus 165-168 10193578-1 1999 Dihydrolipoamide dehydrogenase (LADH) lipoamide reductase activity decreased whereas enzyme diaphorase activity increased after LADH treatment with myeloperoxidase (MPO) dependent systems (MPO/H2O2/halide, MPO/NADH/halide and MPO/H2O2/nitrite systems. Nitrites 235-242 myeloperoxidase Equus caballus 189-192 10193578-1 1999 Dihydrolipoamide dehydrogenase (LADH) lipoamide reductase activity decreased whereas enzyme diaphorase activity increased after LADH treatment with myeloperoxidase (MPO) dependent systems (MPO/H2O2/halide, MPO/NADH/halide and MPO/H2O2/nitrite systems. Nitrites 235-242 myeloperoxidase Equus caballus 189-192 10193578-1 1999 Dihydrolipoamide dehydrogenase (LADH) lipoamide reductase activity decreased whereas enzyme diaphorase activity increased after LADH treatment with myeloperoxidase (MPO) dependent systems (MPO/H2O2/halide, MPO/NADH/halide and MPO/H2O2/nitrite systems. Nitrites 235-242 myeloperoxidase Equus caballus 189-192 9918584-12 1999 The increase in nitrite induced by either ACE or NEP inhibitors or amlodipine was entirely abolished by Nw-nitro-L-arginine methyl ester, HOE 140 (a B2-kinin receptor antagonist), and dichloroisocoumarin (a serine protease inhibitor) in both groups. Nitrites 16-23 angiotensin I converting enzyme Canis lupus familiaris 42-45 11148756-2 1999 Our test system is based on the stimulation of IFN-gamma-primed human (THP-1) and murine (J774A.1 and RAW 264.7) monocytic cell lines by bacterial pyrogens to form neopterin or nitrite, respectively. Nitrites 177-184 interferon gamma Homo sapiens 47-56 10433070-8 1999 (3) In combination, AG completely blocked IL-1beta increased nitrite production, reversed IL-1beta inhibited insulin release by approximately 50%, completely reversed IL-1beta increased HSP-70 expression, but did not reverse IL-1beta inhibited GAD-65 expression. Nitrites 61-68 interleukin 1 beta Rattus norvegicus 42-50 9986918-1 1999 Glycosylated amino acids and glycosylated human serum albumin reduce nitrite to nitric oxide under anaerobic conditions. Nitrites 69-76 albumin Homo sapiens 48-61 10233688-3 1999 Interferon-gamma (IFN-gamma) completely overcame the enhancement of serotonin release and suppression of nitrite production induced by IL-4. Nitrites 105-112 interferon gamma Homo sapiens 0-16 10233688-3 1999 Interferon-gamma (IFN-gamma) completely overcame the enhancement of serotonin release and suppression of nitrite production induced by IL-4. Nitrites 105-112 interferon gamma Homo sapiens 18-27 10233688-3 1999 Interferon-gamma (IFN-gamma) completely overcame the enhancement of serotonin release and suppression of nitrite production induced by IL-4. Nitrites 105-112 interleukin 4 Homo sapiens 135-139 10233688-4 1999 Over several experiments, with or without IL-4 and/or IFN-gamma, serotonin release correlated inversely with nitrite production. Nitrites 109-116 interleukin 4 Homo sapiens 42-46 10233688-4 1999 Over several experiments, with or without IL-4 and/or IFN-gamma, serotonin release correlated inversely with nitrite production. Nitrites 109-116 interferon gamma Homo sapiens 54-63 10071480-11 1999 The initial reduction in total peripheral resistance and blood pressure, and the elevation of nitrite and cGMP levels were still present during somatostatin cotreatment, but values returned to baseline more rapidly at the end of the L-arginine infusion. Nitrites 94-101 somatostatin Homo sapiens 144-156 9930928-10 1999 Nitrite production was induced by IL-1beta, in a dose-dependent manner, in control islets whereas there was no significant increase in production in the islets of BB/S-R rats. Nitrites 0-7 interleukin 1 beta Rattus norvegicus 34-42 12136202-0 1999 Nitrite May Be an Important EDRF Modulator. Nitrites 0-7 alpha hemoglobin stabilizing protein Homo sapiens 28-32 12136202-6 1999 From these results a hypothesis is proposed that nitrite may be an EDRF modulator which controls the nitrosation level of reduced thiols in biological system. Nitrites 49-56 alpha hemoglobin stabilizing protein Homo sapiens 67-71 9794915-6 1998 In cocultured hepatocytes incubated with LPS and IFN-gamma, DNIC and nitrite levels decreased compared with those observed in hepatocytes cultured without macrophages in the same conditions. Nitrites 69-76 interferon gamma Rattus norvegicus 49-58 18967368-8 1998 The limit of detection of the method was calculated as 0.2 mumol dm(-3), and the reproducibility was checked by measuring the peak current for 19 injections of 10 muM nitrite, the standard deviation being 3.7%. Nitrites 167-174 latexin Homo sapiens 163-166 9761768-6 1998 Superoxide-radical generation by PMN was similar for the SP-A-/- and wild-type mice, but nitrite levels were increased in SP-A-/- mice. Nitrites 89-96 surfactant associated protein A1 Mus musculus 122-126 9751495-11 1998 CoCl2 inhibited the marked increase in islet nitrite production in response to IL-1beta. Nitrites 45-52 interleukin 1 beta Rattus norvegicus 79-87 9767541-6 1998 Kallikrein gene transfer caused left ventricular mass reduction and elevated glomerular filtration rate, renal blood flow, urinary excretion, urinary kinin, nitrite/nitrate content, cGMP and cAMP levels. Nitrites 157-164 kallikrein related peptidase 4 Homo sapiens 0-10 9788654-10 1998 Nitrate+nitrite levels returned to normal within 24 h. CRP generation increased during 12 h following trauma and was most marked in severest trauma (ISS >50). Nitrites 8-15 C-reactive protein Homo sapiens 55-58 9786505-18 1998 Our results indicated that andrographolide inhibits nitrite synthesis by suppressing expression of iNOS protein in vitro. Nitrites 52-59 nitric oxide synthase 2 Rattus norvegicus 99-103 9753243-2 1998 Endotoxemia for 6 hr resulted in a 5.9-fold rise in the serum levels of nitrite (P < 0.05) with a significant rise in the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactic dehydrogenase (LDH), suggestive of liver dysfunction. Nitrites 72-79 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 173-199 9753243-2 1998 Endotoxemia for 6 hr resulted in a 5.9-fold rise in the serum levels of nitrite (P < 0.05) with a significant rise in the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactic dehydrogenase (LDH), suggestive of liver dysfunction. Nitrites 72-79 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 201-204 9734601-10 1998 Finally, alpha-MSH inhibited nitrite production by 20% in the mouse cortical tubule cells (MCT), similar to parallel observations in a cultured mouse macrophage line (RAW cells). Nitrites 29-36 pro-opiomelanocortin-alpha Mus musculus 9-18 9734601-12 1998 The preservation of sodium absorption ex vivo and inhibition of nitrite production in cultured MCT cells suggests that alpha-MSH inhibits tubular injury by direct tubular effects. Nitrites 64-71 pro-opiomelanocortin-alpha Mus musculus 119-128 9759949-8 1998 RESULTS: In all of seven specimens from children with increased levels of nitrate/nitrite in the urine, we detected antibodies to iNOS, whereas in five of six control specimens--that is, from children with normal nitrate/nitrite levels--we could not detect any iNOS. Nitrites 82-89 nitric oxide synthase 2 Homo sapiens 130-134 9705211-2 1998 We report that both myeloperoxidase (MPO) and horseradish peroxidase (HRP) utilize nitrite (NO2-) and hydrogen peroxide (H2O2) as substrates to catalyze tyrosine nitration in proteins. Nitrites 83-90 myeloperoxidase Rattus norvegicus 37-40 9865496-5 1998 Our present data show a correlation between the production of nitrite + nitrate (NO2- + NO3-) and that of circulating cytokines IFN and IL-6. Nitrites 62-69 NBL1, DAN family BMP antagonist Homo sapiens 88-91 9865496-5 1998 Our present data show a correlation between the production of nitrite + nitrate (NO2- + NO3-) and that of circulating cytokines IFN and IL-6. Nitrites 62-69 interferon alpha 1 Homo sapiens 128-131 9865496-5 1998 Our present data show a correlation between the production of nitrite + nitrate (NO2- + NO3-) and that of circulating cytokines IFN and IL-6. Nitrites 62-69 interleukin 6 Homo sapiens 136-140 9723949-13 1998 TNF-alpha production was proportional to the indomethacin dose (from 3-20 mg kg(-1)) and correlated with the surface area of ulcerations and nitrite production, 24 h after indomethacin administration. Nitrites 141-148 tumor necrosis factor Rattus norvegicus 0-9 9756389-6 1998 Chondrocytes and patellae, as well as femoral head caps, responded concentration-dependently to IL-1beta challenge (0 to 250 U ml(-1) and 0 to 15 U ml(-1) respectively) by a large increase in nitrite level and a marked suppression of proteoglycan synthesis. Nitrites 192-199 interleukin 1 beta Rattus norvegicus 96-104 9756389-7 1998 Above these concentrations of IL-1beta (2500 U ml(-1) and 30 U ml(-1) respectively), proteoglycan synthesis plateaued whereas nitrite release still increased thus suggesting different concentration-response curves. Nitrites 126-133 interleukin 1 beta Rattus norvegicus 30-38 9681482-3 1998 Incubation of primary rat astrocytes with endotoxin [lipopolysaccharide (LPS)] and proinflammatory cytokines induced NOS-2 gene and protein expression, as assessed by nitrite production and measurement of L-citrulline synthesis in whole cell lysates. Nitrites 167-174 toll-like receptor 4 Mus musculus 73-76 10352496-5 1998 LPC by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose-dependently inhibited IL-1 beta-stimulated nitrite production. Nitrites 138-145 interleukin 1 beta Homo sapiens 117-126 9671763-5 1998 We report here that untreated p53 KO mice excreted 70% more nitrite plus nitrate than mice with wild-type (wt) p53. Nitrites 60-67 transformation related protein 53, pseudogene Mus musculus 30-33 9671763-7 1998 Upon treatment with heat-inactivated Corynebacterium parvum, urinary nitrite plus nitrate excretion of p53 KO mice exceeded that of wt controls by approximately 200%. Nitrites 69-76 transformation related protein 53, pseudogene Mus musculus 103-106 9667498-0 1998 Lactoperoxidase-catalyzed oxidation of melanin by reactive nitrogen species derived from nitrite (NO2-): an EPR study. Nitrites 89-96 lactoperoxidase Homo sapiens 0-15 9667498-2 1998 We observed that in the presence of nitrite LPO/H2O2 generated large amount of melanin radicals, as evidenced by a strong, up to 11-fold, increase in the intensity of the melanin EPR signal. Nitrites 36-43 lactoperoxidase Homo sapiens 44-47 9667498-5 1998 When the nitrite was present, the concentration of melanin radicals was linearly dependent on [NO2-] (for [NO2-] <5 mM), and increased when [LPO] and [H2O2] increased (at constant [NO2-]). Nitrites 9-16 lactoperoxidase Homo sapiens 144-147 9670978-5 1998 PGA2, PGD2, PGJ2, delta12PGJ2, and Wy14,643 reduced nitrite accumulation, with delta12PGJ2 being the most effective. Nitrites 52-59 prostaglandin D2 synthase (brain) Mus musculus 6-10 9670978-7 1998 Inhibition of nitrite accumulation was associated with a fall in inducible NOS protein and an induction of heme oxygenase 1, correlating both dose dependently and temporally. Nitrites 14-21 heme oxygenase 1 Mus musculus 107-123 9688852-3 1998 The LPS-IFN-gamma-induced nitrite release was inhibited in a concentration-dependent manner by these compounds. Nitrites 26-33 interferon gamma Bos taurus 8-17 9689011-3 1998 ATP (10(-3) M) inhibited 24-h nitrite production induced by lipopolysaccharide (LPS, 10 microg/ml)/interferon-gamma (IFN-gamma, 100 U/ml) by 48.2 +/- 6. Nitrites 30-37 interferon gamma Rattus norvegicus 99-115 9689011-3 1998 ATP (10(-3) M) inhibited 24-h nitrite production induced by lipopolysaccharide (LPS, 10 microg/ml)/interferon-gamma (IFN-gamma, 100 U/ml) by 48.2 +/- 6. Nitrites 30-37 interferon gamma Rattus norvegicus 117-126 9689011-5 1998 Also, coincubation with either 10(-4) M of UTP, ATP, or ATPgammaS inhibited LPS/IFN-gamma-induced nitrite production by 29.9 +/- 5.8, 36.4 +/- 4.3, and 50.3 +/- 6.5%, respectively, indicating involvement of purinergic P2Y2 receptors. Nitrites 98-105 interferon gamma Rattus norvegicus 76-89 9689011-5 1998 Also, coincubation with either 10(-4) M of UTP, ATP, or ATPgammaS inhibited LPS/IFN-gamma-induced nitrite production by 29.9 +/- 5.8, 36.4 +/- 4.3, and 50.3 +/- 6.5%, respectively, indicating involvement of purinergic P2Y2 receptors. Nitrites 98-105 purinergic receptor P2Y2 Rattus norvegicus 218-222 9713328-9 1998 In rat islets IL-12 induced a decrease in nitrite formation compared with control islets. Nitrites 42-49 interleukin 12B Rattus norvegicus 14-19 9694586-5 1998 This procedure, supplemented with deproteinization and reduction of nitrates to nitrites in the presence of NADPH-sensitive reductase, can be successfully applied for measurement of NOx levels in human body fluids (serum, urine and CSF). Nitrites 80-88 colony stimulating factor 2 Homo sapiens 232-235 9614147-2 1998 Individually, poly(I-C), interferon-gamma (IFN-gamma), and lipopolysaccharide (LPS) stimulate nitrite production and iNOS expression by RAW 264.7 cells. Nitrites 94-101 interferon gamma Mus musculus 25-41 9614147-2 1998 Individually, poly(I-C), interferon-gamma (IFN-gamma), and lipopolysaccharide (LPS) stimulate nitrite production and iNOS expression by RAW 264.7 cells. Nitrites 94-101 interferon gamma Mus musculus 43-52 9625727-3 1998 Regression analysis of serum ALT levels to serum nitrate plus nitrite levels in individual mice revealed a positive, linear relationship between serum ALT levels and serum nitrate plus nitrite levels with a correlation coefficient of 0.9 (P < 0.05). Nitrites 62-69 glutamic pyruvic transaminase, soluble Mus musculus 151-154 9625727-3 1998 Regression analysis of serum ALT levels to serum nitrate plus nitrite levels in individual mice revealed a positive, linear relationship between serum ALT levels and serum nitrate plus nitrite levels with a correlation coefficient of 0.9 (P < 0.05). Nitrites 185-192 glutamic pyruvic transaminase, soluble Mus musculus 151-154 9747450-9 1998 Only interferon-gamma incubated alone was capable of increasing nitrite levels. Nitrites 64-71 interferon gamma Homo sapiens 5-21 9747450-11 1998 CONCLUSION: We have shown that increased production of nitrite by human vascular tissue in response to cytokines is associated with induction of iNOS as shown at the molecular and protein levels, and further supported by the presence of increased Ca(2+)-independent nitric oxide synthase activity following cytokine stimulation. Nitrites 55-62 nitric oxide synthase 2 Homo sapiens 145-149 9641272-1 1998 Oxidation of oxyhemoglobin by nitrite ions to produce methemoglobin is one of the more employed procedures to oxidize the hemoprotein. Nitrites 30-37 hemoglobin subunit gamma 2 Homo sapiens 54-67 9612942-5 1998 Nitrite formation catalyzed by NR was mainly NADPH-dependent in roots of AM-colonized plants but not in those of the controls, which is consistent with the fact that NRs of fungi preferentially utilize NADPH as reductant. Nitrites 0-7 nitrate reductase [NADH] 1 Zea mays 31-33 10189065-3 1998 Methionine-enkephalin and mu-; delta- and kappa-agonists combined with interferon-gamma plus lipopolysaccharide caused an increase in nitrite release from cultured macrophages. Nitrites 134-141 interferon gamma Mus musculus 71-87 10189065-4 1998 Only 10 mM U-50488 led to a decrease in nitrite release from interferon-gamma and LPS-stimulated macrophages. Nitrites 40-47 interferon gamma Mus musculus 61-77 9671112-2 1998 Stimulation of the J774 cells with lipopolysaccharide together with interferon-gamma resulted in a dose-dependent cytotoxicity and production of PGE2 and NO, measured as nitrite. Nitrites 170-177 interferon gamma Mus musculus 68-84 9585299-4 1998 Incubation of cells with LPS (1 microg/mL) and IFN-gamma (100 u/mL) for 24 h resulted in significant increases in nitrite production and L-arginine transport. Nitrites 114-121 interferon gamma Rattus norvegicus 47-56 9581812-6 1998 Pc4 PDT resulted in a rapid increase in nitrite production in A431 cells, starting as early as 15 s post-PDT, and showed a progressive increase up to 15 min post-PDT. Nitrites 40-47 SUB1 regulator of transcription Homo sapiens 0-3 9573546-7 1998 Kallikrein gene delivery caused a decrease in blood urea nitrogen levels and increases in urinary kinin and nitrite/nitrate levels. Nitrites 108-115 kallikrein related peptidase 4 Homo sapiens 0-10 9667074-1 1998 In rats with gastric mucosal lesions induced by water immersion restraint (WIR) stress over a 6 h period, increases in the serum and gastric mucosal concentrations of nitrite/nitrate, the breakdown products of NO, occurred with a drastic increase in inducible NO synthase (iNOS) activity in the gastric mucosa. Nitrites 167-174 nitric oxide synthase 2 Rattus norvegicus 250-271 9667074-1 1998 In rats with gastric mucosal lesions induced by water immersion restraint (WIR) stress over a 6 h period, increases in the serum and gastric mucosal concentrations of nitrite/nitrate, the breakdown products of NO, occurred with a drastic increase in inducible NO synthase (iNOS) activity in the gastric mucosa. Nitrites 167-174 nitric oxide synthase 2 Rattus norvegicus 273-277 9667074-3 1998 A good positive correlation between either serum or gastric mucosal nitrite/nitrate concentration and gastric mucosal iNOS activity in all rats used (r = 0.741 or 0.842, respectively, p < 0.001) was found. Nitrites 68-75 nitric oxide synthase 2 Rattus norvegicus 118-122 9652371-6 1998 The reduction in lipopolysaccharide-stimulated nitrite accumulation produced by tetracyclines was significantly less when they were applied 6 h after lipopolysaccharide and absent 12 h after lipopolysaccharide, indicating that tetracyclines modify an early event in inducible NO synthase activation operating after mRNA transcription. Nitrites 47-54 nitric oxide synthase 2, inducible Mus musculus 266-287 9645314-2 1998 To identify the presence of IFN-gamma, we combined four typical activities of IFN-gamma: inhibition of cytopathic effect of vesicular stomatitis virus on IFN-gamma-treated fibroblasts, cytostatic activity of IFN-gamma-activated macrophages, induction of major histocompatibility complex II antigen expression on IFN-gamma-activated fibroblasts and macrophages, and induction of nitrite production in macrophages. Nitrites 378-385 interferon gamma Gallus gallus 28-37 9683921-2 1998 METHODS: We measured the accumulation of nitrite, a stable oxidation product of NO synthase (iNOS) protein in cultured neonatal rat cardiac myocytes. Nitrites 41-48 nitric oxide synthase 2 Rattus norvegicus 93-97 9683921-3 1998 RESULTS: Incubation of the cultures with interleukin-1 beta (IL-1 beta; 10 ng/ml) and tumor necrosis factor alpha (TNF alpha; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 164-171 interleukin 1 beta Rattus norvegicus 41-59 9683921-3 1998 RESULTS: Incubation of the cultures with interleukin-1 beta (IL-1 beta; 10 ng/ml) and tumor necrosis factor alpha (TNF alpha; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 164-171 interleukin 1 beta Rattus norvegicus 61-70 9683921-3 1998 RESULTS: Incubation of the cultures with interleukin-1 beta (IL-1 beta; 10 ng/ml) and tumor necrosis factor alpha (TNF alpha; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 164-171 tumor necrosis factor Rattus norvegicus 86-113 9683921-3 1998 RESULTS: Incubation of the cultures with interleukin-1 beta (IL-1 beta; 10 ng/ml) and tumor necrosis factor alpha (TNF alpha; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 164-171 tumor necrosis factor Rattus norvegicus 115-124 9528932-11 1998 Exposure to IL-1beta resulted in 10-fold higher medium nitrite levels in both subpopulations; this effect was prevented by the iNOS blocker, N(G)-methyl-L-arginine, which also prevented the IL-1beta-induced suppression in the glucose-responsive subpopulation. Nitrites 55-62 interleukin 1 beta Rattus norvegicus 12-20 9528932-11 1998 Exposure to IL-1beta resulted in 10-fold higher medium nitrite levels in both subpopulations; this effect was prevented by the iNOS blocker, N(G)-methyl-L-arginine, which also prevented the IL-1beta-induced suppression in the glucose-responsive subpopulation. Nitrites 55-62 nitric oxide synthase 2 Rattus norvegicus 127-131 9554814-9 1998 The effect of these agents on nitrite release was blocked by L-NAME, which inhibits NO synthase, HOE-140, which blocks bradykinin B2-receptor, and dichloroisocoumarin, which blocks kinin-forming enzymes. Nitrites 30-37 kininogen 1 Canis lupus familiaris 119-129 10036860-4 1998 A selective 5-HT1B/1D agonist sumatriptan (0.01-10 mumol/L) caused nitrite production. Nitrites 67-74 5-hydroxytryptamine receptor 1B Homo sapiens 12-18 10682461-11 1998 CONCLUSION: Total nitrites are increased both in maternal and fetal circulation in PIH. Nitrites 18-26 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 83-86 9510167-4 1998 The IL-1R antagonist protein completely prevents TNF + LPS-induced nitrite production, iNOS expression and the inhibitory effects on glucose-stimulated insulin secretion by rat islets. Nitrites 67-74 tumor necrosis factor Rattus norvegicus 49-52 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 interleukin 1 beta Rattus norvegicus 0-8 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 tumor necrosis factor Rattus norvegicus 54-57 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 tumor necrosis factor Rattus norvegicus 89-92 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 interleukin 1 beta Rattus norvegicus 121-129 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 interleukin 1 beta Rattus norvegicus 121-129 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 tumor necrosis factor Rattus norvegicus 89-92 11483289-5 2000 We hypothesized that exogenous nitrite would enhance endothelial ACE dysfunction associated with PMN activation in the isolated lung. Nitrites 31-38 angiotensin I converting enzyme Rattus norvegicus 65-68 9535016-6 1998 In the present study, a cloned murine microglial cell line (N9), stimulated with combined lipopolysaccharide/interferon-gamma (LPS/IFN) incubation, was shown to produce a significant increase in NO formation, as measured by medium nitrite levels, during 8-72 h exposure. Nitrites 231-238 toll-like receptor 4 Mus musculus 127-134 9559891-15 1998 The anti-transforming growth factor-beta1 (TGF-beta1) antibody, which inhibited TGF-beta1-induced suppression of nitrite production from IL-1beta-treated vascular rings, did not affect the inhibitory action of 17beta-oestradiol, suggesting that the effect of oestrogen on iNOS inhibition was not mediated by TGF-beta1. Nitrites 113-120 transforming growth factor, beta 1 Rattus norvegicus 4-41 9559891-4 1998 Treatment of the isolated aortic rings with interleukin-1beta (IL-1beta, 20 micro ml(-1)) led to the expression of iNOS mRNA and protein, as well as significant nitrite accumulation in the incubation media and suppression of phenylephrine (1 nM-10 microM)-evoked contraction. Nitrites 161-168 interleukin 1 beta Rattus norvegicus 44-61 9535019-9 1998 In PDMP-treated VSMC, IL-1beta (3 micro ml[-1])-stimulated release of nitrite (135 +/- 4 nmol mg(-1) protein 48 h[-1]) was significantly increased as compared to IL-1beta-stimulated control cells (40 +/- 3 nmol mg(-1) protein 48 h(-1); n = 6, P < 0.001). Nitrites 70-77 interleukin 1 beta Rattus norvegicus 22-30 9535019-9 1998 In PDMP-treated VSMC, IL-1beta (3 micro ml[-1])-stimulated release of nitrite (135 +/- 4 nmol mg(-1) protein 48 h[-1]) was significantly increased as compared to IL-1beta-stimulated control cells (40 +/- 3 nmol mg(-1) protein 48 h(-1); n = 6, P < 0.001). Nitrites 70-77 interleukin 1 beta Rattus norvegicus 162-170 9559891-15 1998 The anti-transforming growth factor-beta1 (TGF-beta1) antibody, which inhibited TGF-beta1-induced suppression of nitrite production from IL-1beta-treated vascular rings, did not affect the inhibitory action of 17beta-oestradiol, suggesting that the effect of oestrogen on iNOS inhibition was not mediated by TGF-beta1. Nitrites 113-120 transforming growth factor, beta 1 Rattus norvegicus 43-52 9559891-4 1998 Treatment of the isolated aortic rings with interleukin-1beta (IL-1beta, 20 micro ml(-1)) led to the expression of iNOS mRNA and protein, as well as significant nitrite accumulation in the incubation media and suppression of phenylephrine (1 nM-10 microM)-evoked contraction. Nitrites 161-168 interleukin 1 beta Rattus norvegicus 63-71 9559891-7 1998 17Beta-oestradiol (1 nM-10 microM) and the partial oestrogen receptor agonist 4-OH-tamoxifen (1 nM-10 microM) produced concentration-dependent inhibition of IL-1beta-induced nitrite accumulation and restored vasoconstrictor responsiveness to phenylephrine, similar to the iNOS inhibitor aminoguanidine (100 microM). Nitrites 174-181 interleukin 1 beta Rattus norvegicus 157-165 9559891-7 1998 17Beta-oestradiol (1 nM-10 microM) and the partial oestrogen receptor agonist 4-OH-tamoxifen (1 nM-10 microM) produced concentration-dependent inhibition of IL-1beta-induced nitrite accumulation and restored vasoconstrictor responsiveness to phenylephrine, similar to the iNOS inhibitor aminoguanidine (100 microM). Nitrites 174-181 nitric oxide synthase 2 Rattus norvegicus 272-276 9559891-15 1998 The anti-transforming growth factor-beta1 (TGF-beta1) antibody, which inhibited TGF-beta1-induced suppression of nitrite production from IL-1beta-treated vascular rings, did not affect the inhibitory action of 17beta-oestradiol, suggesting that the effect of oestrogen on iNOS inhibition was not mediated by TGF-beta1. Nitrites 113-120 transforming growth factor, beta 1 Rattus norvegicus 80-89 9559891-12 1998 Incubation with tumour necrosis factor alpha (TNF alpha, 1 ng ml(-1)) resulted in significant nitrite accumulation in the incubation media and suppression of the smooth muscle contractile response to phenylephrine, similar to IL-1beta. Nitrites 94-101 tumor necrosis factor Rattus norvegicus 46-58 9559891-15 1998 The anti-transforming growth factor-beta1 (TGF-beta1) antibody, which inhibited TGF-beta1-induced suppression of nitrite production from IL-1beta-treated vascular rings, did not affect the inhibitory action of 17beta-oestradiol, suggesting that the effect of oestrogen on iNOS inhibition was not mediated by TGF-beta1. Nitrites 113-120 interleukin 1 beta Rattus norvegicus 137-145 9559891-15 1998 The anti-transforming growth factor-beta1 (TGF-beta1) antibody, which inhibited TGF-beta1-induced suppression of nitrite production from IL-1beta-treated vascular rings, did not affect the inhibitory action of 17beta-oestradiol, suggesting that the effect of oestrogen on iNOS inhibition was not mediated by TGF-beta1. Nitrites 113-120 transforming growth factor, beta 1 Rattus norvegicus 80-89 9478958-4 1998 Forskolin, the most potent inhibitor of LPS-induced nitrite formation by Kupffer cells, decreased iNOS mRNA levels in a time-dependent manner. Nitrites 52-59 nitric oxide synthase 2 Rattus norvegicus 98-102 9478960-4 1998 Substitution of the culture medium of rat peritoneal macrophages at pH 7.4 with medium at pH 7.0 up-regulated iNOS activity, as reflected by a 2.5-fold increase in nitrite accumulation. Nitrites 164-171 nitric oxide synthase 2 Rattus norvegicus 110-114 9478960-9 1998 Indeed, 1) elevated TNFalpha bioactivity was observed in the medium of macrophages exposed to pH 7.0, and 2) incubation of macrophages with a neutralizing anti-TNFalpha antibody impaired both NF-kappaB activation and nitrite accumulation in response to acid challenge. Nitrites 217-224 tumor necrosis factor Rattus norvegicus 20-28 9659467-5 1998 RESULTS: Interleukin-1 beta (IL-1 beta) induced nitrite production by VSMCs in a time-dependent manner. Nitrites 48-55 interleukin 1 beta Mus musculus 9-27 9659467-5 1998 RESULTS: Interleukin-1 beta (IL-1 beta) induced nitrite production by VSMCs in a time-dependent manner. Nitrites 48-55 interleukin 1 beta Mus musculus 29-38 9659467-6 1998 The addition of the mouse monocyte cell line J774 to IL-1 beta-stimulated VSMCs further increased nitrite production in a monocyte number-dependent manner. Nitrites 98-105 interleukin 1 beta Mus musculus 53-62 9659467-7 1998 Enhanced nitrite production by coculture was accompanied by increased inducible NO synthase protein accumulation. Nitrites 9-16 nitric oxide synthase 2, inducible Mus musculus 70-91 9659467-8 1998 Addition of tumor necrosis factor-alpha (TNF-alpha) also enhanced IL-1 beta-induced nitrite production by VSMCs, but TNF-alpha showed no effect in the presence of monocytes. Nitrites 84-91 tumor necrosis factor Mus musculus 12-39 9659467-8 1998 Addition of tumor necrosis factor-alpha (TNF-alpha) also enhanced IL-1 beta-induced nitrite production by VSMCs, but TNF-alpha showed no effect in the presence of monocytes. Nitrites 84-91 tumor necrosis factor Mus musculus 41-50 9659467-8 1998 Addition of tumor necrosis factor-alpha (TNF-alpha) also enhanced IL-1 beta-induced nitrite production by VSMCs, but TNF-alpha showed no effect in the presence of monocytes. Nitrites 84-91 interleukin 1 beta Mus musculus 66-75 9659467-10 1998 The production of nitrite by coculture was markedly inhibited by an anti-TNF-alpha antibody. Nitrites 18-25 tumor necrosis factor Mus musculus 73-82 9585809-4 1998 L-NMMA and aminoguanidine, competitive inhibitors of iNOS suppressed NO production as measured by the NO byproduct, nitrite, as did IFN-B. Nitrites 116-123 nitric oxide synthase 2 Homo sapiens 53-57 9478960-9 1998 Indeed, 1) elevated TNFalpha bioactivity was observed in the medium of macrophages exposed to pH 7.0, and 2) incubation of macrophages with a neutralizing anti-TNFalpha antibody impaired both NF-kappaB activation and nitrite accumulation in response to acid challenge. Nitrites 217-224 tumor necrosis factor Rattus norvegicus 160-168 9475399-2 1998 We demonstrated that the addition of cytokines and lipopolysaccharides (C+L) to cultured peritubular cells resulted in high nitrite and iNOS mRNA levels, indicating the induction of an iNOS isoform. Nitrites 124-131 nitric oxide synthase 2 Rattus norvegicus 185-189 9494028-6 1998 In marked contrast, amlodipine caused a dose-dependent increase in nitrite production from 74+/-5 to 130+/-8 pmol/mg (by 85+/-21%,10(-5) mol/L, P<.05) that was similar in magnitude to that of either of the ACE inhibitors. Nitrites 67-74 angiotensin I converting enzyme Canis lupus familiaris 209-212 9486266-6 1998 An inhibitor of nitric oxide synthase (NOS) blocked nitrite production, indicating that changes in nitrite reflect NO production. Nitrites 52-59 nitric oxide synthase 1 Homo sapiens 16-37 9486266-6 1998 An inhibitor of nitric oxide synthase (NOS) blocked nitrite production, indicating that changes in nitrite reflect NO production. Nitrites 99-106 nitric oxide synthase 1 Homo sapiens 16-37 9475399-4 1998 Nitrite production in Sertoli cells and peritubular cells required both IFNgamma and TNF alpha and was potentiated by LPS, whereas IL-1alpha was ineffective. Nitrites 0-7 interleukin 18 Rattus norvegicus 72-80 9484793-7 1998 Thus lipocortin 1 mediates, at least in part, the inhibitory action exerted by dexamethasone on both iNOS protein expression in lung and iNOS activity (as measured by nitrite release) in primary peritoneal cells of rats. Nitrites 167-174 annexin A1 Rattus norvegicus 5-17 9468191-4 1998 PGD2 at a concentration of 10(-7) mol/L or greater dose-dependently inhibited nitrite accumulation in the medium of cultured VSMCs stimulated with interleukin 1beta (IL-1beta). Nitrites 78-85 interleukin 1 beta Rattus norvegicus 147-164 9475399-4 1998 Nitrite production in Sertoli cells and peritubular cells required both IFNgamma and TNF alpha and was potentiated by LPS, whereas IL-1alpha was ineffective. Nitrites 0-7 tumor necrosis factor Rattus norvegicus 85-94 9468191-4 1998 PGD2 at a concentration of 10(-7) mol/L or greater dose-dependently inhibited nitrite accumulation in the medium of cultured VSMCs stimulated with interleukin 1beta (IL-1beta). Nitrites 78-85 interleukin 1 beta Rattus norvegicus 166-174 9475399-5 1998 The induction of nitrite production and iNOS mRNA by IFNgamma+TNF alpha+LPS could be further enhanced by basic fibroblast growth factor in Sertoli cells but not in peritubular cells. Nitrites 17-24 interleukin 18 Rattus norvegicus 53-61 9475399-5 1998 The induction of nitrite production and iNOS mRNA by IFNgamma+TNF alpha+LPS could be further enhanced by basic fibroblast growth factor in Sertoli cells but not in peritubular cells. Nitrites 17-24 tumor necrosis factor Rattus norvegicus 62-71 9453609-2 1998 Substantial amounts of nitrite (a degradation product of NO) were produced and the initial rickettsial infection was suppressed in cultures of L929 cells treated with crude lymphokine preparations (LK) or with gamma interferon (IFN-gamma) plus tumor necrosis factor alpha (TNF-alpha) but not in L929 cell cultures treated with IFN-gamma alone or TNF-alpha alone. Nitrites 23-30 interferon gamma Mus musculus 210-237 9645394-4 1998 Conversely, superoxide dismutase (SOD) scavenged the O2.- released and increased the .NO-derived nitrite concentration detected. Nitrites 97-104 superoxide dismutase 1 Homo sapiens 12-32 9645394-4 1998 Conversely, superoxide dismutase (SOD) scavenged the O2.- released and increased the .NO-derived nitrite concentration detected. Nitrites 97-104 superoxide dismutase 1 Homo sapiens 34-37 9453609-2 1998 Substantial amounts of nitrite (a degradation product of NO) were produced and the initial rickettsial infection was suppressed in cultures of L929 cells treated with crude lymphokine preparations (LK) or with gamma interferon (IFN-gamma) plus tumor necrosis factor alpha (TNF-alpha) but not in L929 cell cultures treated with IFN-gamma alone or TNF-alpha alone. Nitrites 23-30 tumor necrosis factor Mus musculus 244-271 9453609-2 1998 Substantial amounts of nitrite (a degradation product of NO) were produced and the initial rickettsial infection was suppressed in cultures of L929 cells treated with crude lymphokine preparations (LK) or with gamma interferon (IFN-gamma) plus tumor necrosis factor alpha (TNF-alpha) but not in L929 cell cultures treated with IFN-gamma alone or TNF-alpha alone. Nitrites 23-30 tumor necrosis factor Mus musculus 273-282 9453609-2 1998 Substantial amounts of nitrite (a degradation product of NO) were produced and the initial rickettsial infection was suppressed in cultures of L929 cells treated with crude lymphokine preparations (LK) or with gamma interferon (IFN-gamma) plus tumor necrosis factor alpha (TNF-alpha) but not in L929 cell cultures treated with IFN-gamma alone or TNF-alpha alone. Nitrites 23-30 interferon gamma Mus musculus 228-237 9453609-2 1998 Substantial amounts of nitrite (a degradation product of NO) were produced and the initial rickettsial infection was suppressed in cultures of L929 cells treated with crude lymphokine preparations (LK) or with gamma interferon (IFN-gamma) plus tumor necrosis factor alpha (TNF-alpha) but not in L929 cell cultures treated with IFN-gamma alone or TNF-alpha alone. Nitrites 23-30 tumor necrosis factor Mus musculus 346-355 9453609-4 1998 Antibody-mediated neutralization of the IFN-gamma in the LK also inhibited both nitrite production and suppression of the initial rickettsial infection. Nitrites 80-87 interferon gamma Mus musculus 40-49 9453315-8 1998 Tissue slices of the renal cortex and medulla were studied to determine the effects of Ang II and L-NAME on the nitrite/nitrate production. Nitrites 112-119 angiotensinogen Rattus norvegicus 87-93 9541275-10 1998 In primary cultured rat glial cells, a combination of cytokines stimulated production of nitrite via expression of inducible NO synthase. Nitrites 89-96 nitric oxide synthase 2 Rattus norvegicus 115-136 9532589-5 1998 Nitrate and nitrite, were raised in the CSF and serum of patients with multiple sclerosis and other inflammatory neurological diseases compared to patients with non-inflammatory neurological disorders (median nitrate and nitrite: cerebrospinal fluid = 10.3 microM vs 15.4 microM vs 6.6 microM, P < 0.001, and serum = 49.0 microM vs 46.4 microM vs 38.8 microM, P = 0.02, respectively). Nitrites 12-19 colony stimulating factor 2 Homo sapiens 40-43 9458730-4 1998 NO production, measured by the accumulation of nitrite and nitrate, was enhanced by 10(-7) M ANG II. Nitrites 47-54 angiotensinogen Rattus norvegicus 93-99 9450756-4 1998 We have recently demonstrated that nitrite (NO2-), a major end-product of .NO metabolism, readily promotes tyrosine nitration through formation of nitryl chloride (NO2Cl) and nitrogen dioxide (.NO2) by reaction with the inflammatory mediators hypochlorous acid (HOCl) or myeloperoxidase. Nitrites 35-42 myeloperoxidase Homo sapiens 271-286 9453315-9 1998 Ang II stimulated the nitrite/nitrate production predominately in the renal medulla, which was significantly attenuated by L-NAME. Nitrites 22-29 angiotensinogen Rattus norvegicus 0-6 9585124-3 1998 In these cells, simultaneous addition of endothelin (ET) markedly inhibited TNF-alpha/IL-1beta-induced and LPS-induced nitrite production and iNOS expression, although ET by itself had no effect. Nitrites 119-126 tumor necrosis factor Rattus norvegicus 76-85 9661135-6 1998 RESULTS: IL-1 beta stimulated nitrite production in VSMC. Nitrites 30-37 interleukin 1 beta Rattus norvegicus 9-18 9661135-8 1998 Both 8-bromo-guanosine 3",5"-cyclic monophosphate (8-br-cGMP) and dibutylyl adenosine 3",5"-cyclic monophate enhanced IL-1 beta-induced nitrite production. Nitrites 136-143 interleukin 1 beta Rattus norvegicus 118-127 10806781-3 1998 The results were as follows: The content of nitrite and TNF-alpha in patients with malignant bone tumors was significantly higher than that in normal control; the content of nitrite and TNF-alpha in the malignant bone tumor group presented the positive correlation (r = 0.8909, P < 0.01). Nitrites 44-51 tumor necrosis factor Homo sapiens 186-195 9585124-2 1998 In primary cultured rat glial cells, a combination of inflammatory cytokines (tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta)) and bacterial lipopolysaccharide (LPS) stimulates production of nitrite via expression of the inducible form of nitric oxide synthase (iNOS). Nitrites 216-223 interleukin 1 beta Rattus norvegicus 122-139 9706250-9 1998 We conclude: 1) in addition to decreased granularity in atrial myocardiocytes, high circulating values of ANF here described suggest an increased turnover of the peptide in 2K2C hypertensive rats; 2) lower significant vascular relaxant effects in HT rats would indicate down regulation of ANF receptors in this model; the latter would derive from high plasma ANF concentration and, tentatively, because of greater activity of protein kinase C in the vascular wall; 39 similar values of plasma nitrite/nitrate in SH and HT rats would indicate a comparable NO circulating availability in both groups. Nitrites 493-500 natriuretic peptide A Rattus norvegicus 106-109 16793713-5 1998 A significant and inverse correlation of nitrate/nitrite excretion with endothelial markers (von Willebrand factor, soluble thrombomodulin) was documented. Nitrites 49-56 thrombomodulin Homo sapiens 124-138 10100492-6 1998 Inhibition of nitric oxide synthesis with L-NAME during activation with IFN-gamma + LPS reduced NO2- production to the same extent in both cell lines; however, cellular accumulation of nitrotyrosine was reduced by only 25% in the transfectant (P = 0.21) and 49% in the parent cell line (P = 0.007), suggesting that intracellular nitrite increased nitrotyrosine accumulation through a pathway not requiring NO synthesis, i.e., myeloperoxidase system. Nitrites 329-336 interferon gamma Mus musculus 72-81 9851362-5 1998 In addition, the above-mentioned changes in iNOS activity and LPO and NP-SH concentrations with lesion development in the gastric mucosa of rats with WIR stress were attenuated with both prevention of the lesion development and an increase in the concentration of gastric mucosal nitrite/nitrate, the breakdown products of NO, by pretreatment with aminoguanidine, a selective iNOS inhibitor. Nitrites 280-287 nitric oxide synthase 2 Rattus norvegicus 44-48 9405417-3 1997 These types of interferons did not aid LPS in the production of nitrite, but markedly inhibited in a concentration-dependent manner the nitrite release due to LPS/IFN-gamma. Nitrites 136-143 interferon gamma Bos taurus 163-172 9607004-6 1998 The specific nitric oxide synthase inhibitor, aminoguanidine, and anti-IFN-gamma antibody blocked formation of nitrite by the macrophages and spleen cells. Nitrites 111-118 interferon gamma Mus musculus 71-80 9440646-7 1997 Nitrite levels were significantly increased in rectal dialysates during colitis and correlated significantly with tissue myeloperoxidase and iNOS activity. Nitrites 0-7 myeloperoxidase Rattus norvegicus 121-136 9437521-4 1997 Here we report that in the presence of nitrite ions (NO2-), MXH2 undergoes oxidation by the mammalian enzyme lactoperoxidase (LPO) and hydrogen peroxide and that the process proceeds at a rate that is proportional to NO2- concentration. Nitrites 39-46 lactoperoxidase Homo sapiens 109-124 9437521-4 1997 Here we report that in the presence of nitrite ions (NO2-), MXH2 undergoes oxidation by the mammalian enzyme lactoperoxidase (LPO) and hydrogen peroxide and that the process proceeds at a rate that is proportional to NO2- concentration. Nitrites 39-46 lactoperoxidase Homo sapiens 126-129 9436821-5 1997 The activity of iNOS was assessed by the accumulation of nitrite in the conditioned medium of cultured VSMCs and by the hyporeactivity of carotid arteries to phenylephrine. Nitrites 57-64 nitric oxide synthase 2 Homo sapiens 16-20 9436821-7 1997 The IL-1beta-stimulated increase in nitrite formation, iNOS protein, and mRNA abundance in VSMCs was significantly augmented in the presence of thiopental (100 microM), whereas methohexital, hexobarbital, pentobarbital, and phenobarbital were without effect. Nitrites 36-43 interleukin 1 beta Homo sapiens 4-12 9440646-7 1997 Nitrite levels were significantly increased in rectal dialysates during colitis and correlated significantly with tissue myeloperoxidase and iNOS activity. Nitrites 0-7 nitric oxide synthase 2 Rattus norvegicus 141-145 9440646-8 1997 The correlation between nitrite dialysate levels and wall iNOS activity confirms that nitrite in dialysates is produced by inflammatory cells and not by colonic bacterial flora. Nitrites 24-31 nitric oxide synthase 2 Rattus norvegicus 58-62 9440646-8 1997 The correlation between nitrite dialysate levels and wall iNOS activity confirms that nitrite in dialysates is produced by inflammatory cells and not by colonic bacterial flora. Nitrites 86-93 nitric oxide synthase 2 Rattus norvegicus 58-62 9450620-4 1997 Furthermore, inhibition of lipopolysaccharide-induced nitrite production by glucocorticoid-induced proteins in J774 cells was reversed by addition of anti-lipocortin-1 neutralizing polyclonal antibody (1:60 dilution; 4 h before lipopolysaccharide). Nitrites 54-61 annexin A1 Mus musculus 155-167 9389745-4 1997 Treatment of mesangial cells with IL-1beta induces iNOS activity measured as nitrite levels in cell culture supernatants. Nitrites 77-84 interleukin 1 beta Rattus norvegicus 34-42 9389745-4 1997 Treatment of mesangial cells with IL-1beta induces iNOS activity measured as nitrite levels in cell culture supernatants. Nitrites 77-84 nitric oxide synthase 2 Rattus norvegicus 51-55 9389745-11 1997 Treatment of mesangial cells with the membrane-permeable cAMP analogue N6, O-2"-dibutyryladenosine 3",5"-phosphate (Bt2cAMP) markedly increases the production of nitrite. Nitrites 162-169 cathelicidin antimicrobial peptide Rattus norvegicus 57-61 9473147-6 1997 The upregulation of CAT-2 expression by TNF-alpha was associated with enhanced nitrite accumulation in the culture medium (70% increase compared with vehicle-treated cells at 24 h). Nitrites 79-86 solute carrier family 7 member 2 Homo sapiens 20-25 9473147-6 1997 The upregulation of CAT-2 expression by TNF-alpha was associated with enhanced nitrite accumulation in the culture medium (70% increase compared with vehicle-treated cells at 24 h). Nitrites 79-86 tumor necrosis factor Homo sapiens 40-49 9450620-2 1997 We report here that proteins recovered from the medium of dexamethasone-treated J774 macrophages (1, 10, 100 microg/ml) inhibited lipopolysaccharide-stimulated nitrite generation by 10.0 +/- 3.0%, 32.3 +/- 5.3% and 55.0 +/- 6.0%, respectively, and inducible NO synthase mRNA expression in these cells. Nitrites 160-167 nitric oxide synthase 2, inducible Mus musculus 248-269 9393827-11 1997 In cultured sheep and goat Mphi, a low proportion of cells expressed iNOS upon activation by L. monocytogenes and gamma interferon, resulting in nitrite generation at least 1 order of magnitude lower than that in similarly treated cattle Mphi. Nitrites 145-152 nitric oxide synthase, inducible Capra hircus 69-73 9421853-2 1997 Pretreatment of macrophages with IL-4 or IL-13 caused a similar, concentration-dependent inhibition of the formation of nitrite and the expression of iNOS protein elicited by LPS. Nitrites 120-127 interleukin 4 Rattus norvegicus 33-37 9421853-2 1997 Pretreatment of macrophages with IL-4 or IL-13 caused a similar, concentration-dependent inhibition of the formation of nitrite and the expression of iNOS protein elicited by LPS. Nitrites 120-127 interleukin 13 Rattus norvegicus 41-46 9421853-3 1997 In contrast, IL-13 was a much more potent inhibitor of the formation of nitrite and the expression of iNOS protein in activated RASM than IL-4. Nitrites 72-79 interleukin 13 Rattus norvegicus 13-18 9421853-4 1997 IL-10 caused only a small, but significant, inhibition of the nitrite formation induced by LPS in macrophages and RASM. Nitrites 62-69 interleukin 10 Rattus norvegicus 0-5 9421853-4 1997 IL-10 caused only a small, but significant, inhibition of the nitrite formation induced by LPS in macrophages and RASM. Nitrites 62-69 toll-like receptor 4 Mus musculus 91-94 9369275-4 1997 Interleukin-1beta (0.03 U/L) stimulated nitrite release by the aortic vessels. Nitrites 40-47 interleukin 1 beta Rattus norvegicus 0-17 9367897-2 1997 Treatment of retinal Muller glial (RMG) and retinal pigmented epithelial (RPE) cells from both wild-type and knockout mice with LPS and interferon gamma (IFN gamma) induced NO synthesis as determined by nitrite release into the media and was correlated to an increase in NOS-2 mRNA levels, evaluated by RT-PCR. Nitrites 203-210 interferon gamma Mus musculus 136-163 9367897-3 1997 However, the level of nitrite and the accumulation of mRNA was always less in cells from LT alpha/TNF alpha knockout mice than in wild type mice. Nitrites 22-29 lymphotoxin A Mus musculus 89-97 9394817-3 1997 Inducible NO synthase (iNOs) expression was not evidenced in non-stimulated MMC obtained by culture of hematopoietic progenitors in the presence of interleukin-3, whereas IgE-antigen-stimulated MMC expressed iNOs mRNA and protein and synthesized nitrites. Nitrites 246-254 nitric oxide synthase 2, inducible Mus musculus 0-21 9394817-3 1997 Inducible NO synthase (iNOs) expression was not evidenced in non-stimulated MMC obtained by culture of hematopoietic progenitors in the presence of interleukin-3, whereas IgE-antigen-stimulated MMC expressed iNOs mRNA and protein and synthesized nitrites. Nitrites 246-254 nitric oxide synthase 2, inducible Mus musculus 23-27 9427324-2 1997 BV-2 cells, activated with lipopolysaccharide (LPS), exhibited an increase in Mn-SOD-like immunoreactivity, that was associated with an accumulation of nitrite in the culture medium and an increase in immunoreactivity for the inducible type of nitric oxide synthase (i-NOS). Nitrites 152-159 superoxide dismutase 2, mitochondrial Mus musculus 78-84 9427324-3 1997 The i-NOS inhibitor L-N6-(1-iminoethyl)-lysine (NIL, 600 microM) suppressed the nitrite accumulation and the increase in Mn-SOD-like immunoreactivity in activated cells without significant effect on the level of i-NOS-like immunoreactivity. Nitrites 80-87 nitric oxide synthase 2, inducible Mus musculus 4-9 9366711-9 1997 Nitrite and nitrate levels of the liver, ileum, and blood were higher in the iNOS+/+ mice (P < .05). Nitrites 0-7 nitric oxide synthase 2, inducible Mus musculus 77-81 9408009-3 1997 Incubation of the cultures with interleukin-1beta (10 ng/ml) caused a significant increase in nitrite production. Nitrites 94-101 interleukin 1 beta Rattus norvegicus 32-49 9369263-6 1997 For instance, the highest dose of bradykinin, ramiprilat, A23187, kallikrein, and kininogen markedly increased nitrite production, from 60+/-10 to 156+/-12, 153+/-11, 161+/-15, 176+/-15, and 168+/-16 pmol/mg (all P<.05), respectively. Nitrites 111-118 kininogen 1 Canis lupus familiaris 34-44 9369263-8 1997 For instance, nitrite production elicited by bradykinin, ramiprilat, A23187, and kininogen was reduced to 95+/-8, 87+/-8, 94+/-11, and 85+/-11 pmol/mg (all P<.05), respectively, by the kinin antibody. Nitrites 14-21 kininogen 1 Canis lupus familiaris 45-55 9669207-9 1997 Lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) stimulated release of nitrite, lactate dehydrogenase (LDH), TNF alpha, IL-1 beta and IL-8 from rat peritoneal macrophages, all of which were significantly reduced by ITU. Nitrites 80-87 interferon gamma Rattus norvegicus 29-45 9669207-9 1997 Lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) stimulated release of nitrite, lactate dehydrogenase (LDH), TNF alpha, IL-1 beta and IL-8 from rat peritoneal macrophages, all of which were significantly reduced by ITU. Nitrites 80-87 interferon gamma Rattus norvegicus 47-56 9405166-6 1997 Only in high concentration - the specific proinflammatory action being documented by an enhanced release of interleukin-6 from cardiomyocytes - TNF alpha (1000 U/mol; 6, 24 h) weakly induces the mRNA for iNOS, with a consecutive moderate rise in cellular nitrite production. Nitrites 255-262 tumor necrosis factor Homo sapiens 144-153 9405166-6 1997 Only in high concentration - the specific proinflammatory action being documented by an enhanced release of interleukin-6 from cardiomyocytes - TNF alpha (1000 U/mol; 6, 24 h) weakly induces the mRNA for iNOS, with a consecutive moderate rise in cellular nitrite production. Nitrites 255-262 nitric oxide synthase 2 Homo sapiens 204-208 9375806-4 1997 We show that the interleukin-1 receptor antagonist protein (IRAP) prevents IL-1beta-induced nitrite formation and IL-1beta-induced inhibition of insulin secretion by isolated islets and primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitrites 92-99 interleukin 1 receptor antagonist Rattus norvegicus 17-58 9375806-4 1997 We show that the interleukin-1 receptor antagonist protein (IRAP) prevents IL-1beta-induced nitrite formation and IL-1beta-induced inhibition of insulin secretion by isolated islets and primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitrites 92-99 interleukin 1 receptor antagonist Rattus norvegicus 60-64 9375806-4 1997 We show that the interleukin-1 receptor antagonist protein (IRAP) prevents IL-1beta-induced nitrite formation and IL-1beta-induced inhibition of insulin secretion by isolated islets and primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitrites 92-99 interleukin 1 beta Rattus norvegicus 75-83 9375806-6 1997 To provide direct evidence to support beta-cell expression of IL-1 type I signaling receptors, we show that antiserum specific for the type I IL-1 receptor neutralizes IL-1beta-induced nitrite formation by RINm5F cells, and that RINm5F cells express the type I IL-1 receptor at the protein level. Nitrites 185-192 interleukin 1 beta Rattus norvegicus 168-176 9408009-4 1997 5-HT inhibited nitrite production by interleukin-1beta -stimulated vascular smooth muscle cells in a concentration-dependent manner (10(-8)-10(-5) M). Nitrites 15-22 interleukin 1 beta Rattus norvegicus 37-54 9322941-3 1997 Whereas ANP dose dependently (10(-6)-10(-8) M) inhibited NO synthesis (measured as nitrite accumulation, 20h) in all four types of macrophages (bone marrow derived and peritoneal macrophages; RAW 264.7 and J 774), urodilatin and atriopeptin I displayed only a weak effect restricted to the highest concentration (10(-6) M) employed. Nitrites 83-90 natriuretic peptide A Homo sapiens 8-11 9402285-3 1997 Both follicular nitrite (r = 0.42, P < 0.01) and nitrate (r = 0.49, P < 0.001) were found to be significantly correlated with follicular IL-1beta concentrations. Nitrites 16-23 interleukin 1 beta Homo sapiens 143-151 9355146-8 1997 The increased nitrite production by the K-strain and MQ-NCSU macrophages corresponded to an increased expression of iNOS mRNA as compared to the mRNA produced by GB1 and GB2 macrophages. Nitrites 14-21 nitric oxide synthase 2 Gallus gallus 116-120 9355146-8 1997 The increased nitrite production by the K-strain and MQ-NCSU macrophages corresponded to an increased expression of iNOS mRNA as compared to the mRNA produced by GB1 and GB2 macrophages. Nitrites 14-21 gamma-aminobutyric acid type B receptor subunit 1 Homo sapiens 162-165 9355146-8 1997 The increased nitrite production by the K-strain and MQ-NCSU macrophages corresponded to an increased expression of iNOS mRNA as compared to the mRNA produced by GB1 and GB2 macrophages. Nitrites 14-21 gamma-aminobutyric acid type B receptor subunit 2 Homo sapiens 170-173 9378986-6 1997 The PDTC concentration-dependent reductions in iNOS activity produced similar decreases in plasma nitrite/nitrate concentrations. Nitrites 98-105 nitric oxide synthase 2 Rattus norvegicus 47-51 9351506-8 1997 Incubation of rat aortic smooth muscle cells with zymosan-activated plasma (ZAP) induced the production of nitrite, the breakdown product of NO, due to the expression of the inducible isoform of NO synthase (iNOS) over 6 24 h. In addition, ZAP triggered the production of peroxynitrite in these cells, as measured by the oxidation of the fluorescent dye dihydrorhodamine 123 and by nitrotyrosine Western blotting. Nitrites 107-114 nitric oxide synthase 2 Rattus norvegicus 208-212 9336394-2 1997 Interleukin-1beta time- and dose-dependently enhanced the production of nitrite, a stable metabolite of nitric oxide. Nitrites 72-79 interleukin 1 beta Rattus norvegicus 0-17 9336394-3 1997 Parathyroid hormone-related protein(1-34) alone up to 10(-7) mol/L had no obvious effect, but significantly increased the cytokine-induced nitrite production. Nitrites 139-146 parathyroid hormone-like hormone Rattus norvegicus 0-35 9322941-9 1997 Reduction of nitrite accumulation by ANP was highest when added simultaneously with LPS and abolished when added 12 h after LPS stimulation. Nitrites 13-20 natriuretic peptide A Homo sapiens 37-40 9415301-10 1997 CONCLUSIONS: These studies demonstrate successful transfer of endothelial nitric oxide synthase into porcine coronary arteries as verified by histochemical localization of recombinant protein with an increase of nitric oxide release as demonstrated by enhanced nitrite production and an alteration in vasomotor function. Nitrites 261-268 nitric oxide synthase 3 Bos taurus 62-95 9400741-9 1997 Rat AM, stimulated with either LPS or IFN-gamma, produced nitrite in a time- and dose-dependent manner. Nitrites 58-65 interferon gamma Rattus norvegicus 38-47 9400741-10 1997 Combination of LPS and IFN-gamma resulted in a significantly enhanced nitrite formation. Nitrites 70-77 interferon gamma Rattus norvegicus 23-32 9369379-5 1997 Increasing concentrations of TNF-alpha (0.5-50 ng/ml) for 24 h resulted in a concentration-dependent decrease in lipoprotein lipase activity with reciprocal increase in nitrite production in the medium. Nitrites 169-176 tumor necrosis factor Homo sapiens 29-38 9295837-1 1997 OBJECTIVES: To examine the relationship between circulating methemoglobin and nitrite/nitrate concentrations and to compare these markers of nitric oxide overproduction with clinical variables in children diagnosed with septic shock. Nitrites 78-85 hemoglobin subunit gamma 2 Homo sapiens 60-73 9314409-8 1997 Human eNOS gene delivery induces significant increases in urinary and aortic cGMP levels and urinary and serum nitrite/nitrate content (P<.05), while no significant differences in body weight, heart rate, water intake, food consumption, or urine excretion were observed. Nitrites 111-118 nitric oxide synthase 3 Homo sapiens 6-10 9331268-5 1997 RESULTS: Exposure of BCE cells and keratocytes to LPS and IFN-gamma resulted in an increase of nitrite levels that was potentiate by the addition of TNF-alpha. Nitrites 95-102 interferon gamma Bos taurus 58-67 9339386-3 1997 RESULTS: Addition of TGF-beta 2 dose-dependently suppresses IL-1 beta-induced nitrite formation. Nitrites 78-85 transforming growth factor, beta 2 Rattus norvegicus 21-31 9339386-3 1997 RESULTS: Addition of TGF-beta 2 dose-dependently suppresses IL-1 beta-induced nitrite formation. Nitrites 78-85 interleukin 1 beta Rattus norvegicus 60-69 9339386-4 1997 Western and Northern blot analyses of mesangial cell extracts reveal that the inhibition of IL-1 beta-induced nitrite formation by TGF-beta 2 is due to decreased iNOS protein and iNOS mRNA steady state levels. Nitrites 110-117 interleukin 1 beta Rattus norvegicus 92-101 9339386-4 1997 Western and Northern blot analyses of mesangial cell extracts reveal that the inhibition of IL-1 beta-induced nitrite formation by TGF-beta 2 is due to decreased iNOS protein and iNOS mRNA steady state levels. Nitrites 110-117 transforming growth factor, beta 2 Rattus norvegicus 131-141 9339386-4 1997 Western and Northern blot analyses of mesangial cell extracts reveal that the inhibition of IL-1 beta-induced nitrite formation by TGF-beta 2 is due to decreased iNOS protein and iNOS mRNA steady state levels. Nitrites 110-117 nitric oxide synthase 2 Rattus norvegicus 162-166 9339386-4 1997 Western and Northern blot analyses of mesangial cell extracts reveal that the inhibition of IL-1 beta-induced nitrite formation by TGF-beta 2 is due to decreased iNOS protein and iNOS mRNA steady state levels. Nitrites 110-117 nitric oxide synthase 2 Rattus norvegicus 179-183 9331268-5 1997 RESULTS: Exposure of BCE cells and keratocytes to LPS and IFN-gamma resulted in an increase of nitrite levels that was potentiate by the addition of TNF-alpha. Nitrites 95-102 tumor necrosis factor Bos taurus 149-158 9331268-6 1997 Analysis by RT-PCR demonstrated that nitrite release was correlated to the expression of NOS-2 messenger RNA in BCE cells and keratocytes. Nitrites 37-44 nitric oxide synthase 2 Bos taurus 89-94 9331268-7 1997 Stereoselective inhibitors of NOS and cycloheximide inhibited LPS-IFN-gamma-induced nitrite release in both cells, whereas transforming growth factor-beta (TGF-beta) slightly potentiated it. Nitrites 84-91 interferon gamma Bos taurus 66-75 9331268-8 1997 Fibroblast growth factor-2 (FGF-2) inhibited LPS-IFN-gamma-induced nitrite release and NOS-2 messenger RNA accumulation in keratocytes but not in BCE cells. Nitrites 67-74 fibroblast growth factor 2 Bos taurus 0-26 9331268-8 1997 Fibroblast growth factor-2 (FGF-2) inhibited LPS-IFN-gamma-induced nitrite release and NOS-2 messenger RNA accumulation in keratocytes but not in BCE cells. Nitrites 67-74 fibroblast growth factor 2 Bos taurus 28-33 9331268-8 1997 Fibroblast growth factor-2 (FGF-2) inhibited LPS-IFN-gamma-induced nitrite release and NOS-2 messenger RNA accumulation in keratocytes but not in BCE cells. Nitrites 67-74 interferon gamma Bos taurus 49-58 9307076-8 1997 Nitrite production was enhanced when the MDM were primed (pretreated) with gamma or alpha interferon or other immune mediators such as IL-4 and was reduced by the iNOS inhibitor, N-methyl-L-arginine (L-NMMA). Nitrites 0-7 interleukin 4 Homo sapiens 135-139 9307076-8 1997 Nitrite production was enhanced when the MDM were primed (pretreated) with gamma or alpha interferon or other immune mediators such as IL-4 and was reduced by the iNOS inhibitor, N-methyl-L-arginine (L-NMMA). Nitrites 0-7 nitric oxide synthase 2 Homo sapiens 163-167 9281616-1 1997 This study demonstrates that exposure of primary rat hepatocytes or mouse BNL Cl.2 liver cell line to ethanol causes potentiation of tumor necrosis factor-alpha (TNF-alpha)- and lipopolysaccharide (LPS)-stimulated nitrite accumulation. Nitrites 214-221 tumor necrosis factor Mus musculus 133-160 9299361-7 1997 Simultaneous incubation with IL-1beta in the presence of the NOS inhibitor NG-monomethyl-l-arginine or the RNA synthesis inhibitor actinomycin D for 24 h completely inhibited ANP- and BNP- as well as IL-1beta-induced nitrite production. Nitrites 217-224 interleukin 1 beta Homo sapiens 29-37 9316879-3 1997 We found that chronic proteasome inhibition using MG-341 significantly attenuated the peptidoglycan/polysaccharide (PG/PS)-induced up-regulation of iNOS in the colon and spleen and the consequent increase in plasma levels of nitrate and nitrite. Nitrites 237-244 nitric oxide synthase 2 Homo sapiens 148-152 9375500-2 1997 The iNOS activity was determined by L-citrulline and nitrite measurement. Nitrites 53-60 nitric oxide synthase 2 Homo sapiens 4-8 9281616-3 1997 Consistent with nitrite production, the amount of inducible nitric oxide synthase (iNOS) mRNA and protein is initially detected at 4 hr after treatment with TNF-alpha/LPS/ethanol. Nitrites 16-23 nitric oxide synthase 2 Rattus norvegicus 50-81 9281616-3 1997 Consistent with nitrite production, the amount of inducible nitric oxide synthase (iNOS) mRNA and protein is initially detected at 4 hr after treatment with TNF-alpha/LPS/ethanol. Nitrites 16-23 nitric oxide synthase 2 Rattus norvegicus 83-87 9281616-3 1997 Consistent with nitrite production, the amount of inducible nitric oxide synthase (iNOS) mRNA and protein is initially detected at 4 hr after treatment with TNF-alpha/LPS/ethanol. Nitrites 16-23 tumor necrosis factor Rattus norvegicus 157-166 9242464-5 1997 Inhibition of iNOS in vivo was confirmed by decreases in plasma nitrite + nitrate concentrations in treated animals compared with that of controls (63-83% decreases for all experiments) and was supported by plasma and tumor concentrations of 1400W that were equivalent and 2.6-4.9 times higher than the EC50 previously reported for iNOS in a tissue assay. Nitrites 64-71 nitric oxide synthase 2, inducible Mus musculus 14-18 9293967-10 1997 Nitrite production in response to ACE inhibition was blocked by N-nitro-L-arginine methyl ester (L-NAME), a NO synthase inhibitor, and icatibant (HOE 140), a B2-kinin receptor-specific antagonist. Nitrites 0-7 angiotensin I converting enzyme Homo sapiens 34-37 9242548-5 1997 The NO release from iNOS-transfected cells, as measured by nitrite and nitrate accumulation and by cyclic guanosine monophosphate (cGMP) increases in rat reporter cells, was inhibitable (P < .01 for both) with N(omega)-methyl-L-arginine (L-NMA), a NOS inhibitor. Nitrites 59-66 nitric oxide synthase 2 Rattus norvegicus 20-24 9245483-5 1997 Dexamethasone (1 microM) increased the production of NO in IL-1beta-treated rat islets, as measured by the concentration of nitrite in the media. Nitrites 124-131 interleukin 1 beta Rattus norvegicus 59-67 9231726-2 1997 In these cells, simultaneous addition of endothelin (ET) decreased iNOS expression and nitrite accumulation induced by TNF-alpha/IL-1beta. Nitrites 87-94 tumor necrosis factor Rattus norvegicus 119-128 9231726-1 1997 In primary cultured rat glial cells, a combination of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) stimulates production of nitrite via expression of the inducible form of nitric oxide synthase (iNOS). Nitrites 183-190 tumor necrosis factor Rattus norvegicus 85-112 9231726-2 1997 In these cells, simultaneous addition of endothelin (ET) decreased iNOS expression and nitrite accumulation induced by TNF-alpha/IL-1beta. Nitrites 87-94 interleukin 1 beta Rattus norvegicus 129-137 9231726-1 1997 In primary cultured rat glial cells, a combination of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) stimulates production of nitrite via expression of the inducible form of nitric oxide synthase (iNOS). Nitrites 183-190 tumor necrosis factor Rattus norvegicus 114-123 9231726-1 1997 In primary cultured rat glial cells, a combination of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) stimulates production of nitrite via expression of the inducible form of nitric oxide synthase (iNOS). Nitrites 183-190 interleukin 1 beta Rattus norvegicus 129-146 9252519-4 1997 Dose-dependent inhibition of interleukin-1 beta- and interferon-gamma-stimulated nitrite/nitrate production was observed when cells were preincubated for 6 h with UDCA (0-800 microM), and a substantial inhibition (81 +/- 3.2%) was seen at 500 microM. Nitrites 81-88 interleukin 1 beta Homo sapiens 29-69 9231726-1 1997 In primary cultured rat glial cells, a combination of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) stimulates production of nitrite via expression of the inducible form of nitric oxide synthase (iNOS). Nitrites 183-190 interleukin 1 beta Rattus norvegicus 148-156 9231726-1 1997 In primary cultured rat glial cells, a combination of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) stimulates production of nitrite via expression of the inducible form of nitric oxide synthase (iNOS). Nitrites 183-190 nitric oxide synthase 2 Rattus norvegicus 254-258 9233642-5 1997 Additional experiments revealed that accessory cells in peritoneal cell populations were the principal target for the action of IFN-gamma and the main source of nitric oxide; the cytokine was more potent on unfractionated compared with purified mast cells, and IFN-gamma induced detectable nitrite production in mixed peritoneal cells, but not in purified mast cells. Nitrites 290-297 interferon gamma Mus musculus 128-137 9259476-5 1997 iNOS-enzyme activity was determined by measurement of nitrite in the supernatants of cell culture using the Griess-reaction. Nitrites 54-61 nitric oxide synthase 2 Rattus norvegicus 0-4 9252565-6 1997 Nitrite production by rat aortic macrovascular endothelial cells (RAEC) was significantly greater than that by the rat lung microvascular endothelial cells (RLMVEC) when stimulated with TNF-alpha + IFN-gamma, LPS + IFN-gamma, or TNF-alpha + LPS. Nitrites 0-7 tumor necrosis factor Rattus norvegicus 186-195 9249475-2 1997 Incubation of cultures with interleukin-1 beta (10 ng/ml) for 24 h caused a significant increase in nitrite production. Nitrites 100-107 interleukin 1 beta Rattus norvegicus 28-46 9249475-3 1997 The interleukin-1 beta-induced nitrite production by cardiac myocytes was significantly increased by adenosine or its stable analog 2-chloroadenosine in a dose-dependent manner (10(-7)-10(-4) M). Nitrites 31-38 interleukin 1 beta Rattus norvegicus 4-22 9249475-5 1997 The 2-chloroadenosine-induced nitrite production by interleukin-1 beta-stimulated cells was accompanied by inducible NO synthase mRNA and protein accumulation. Nitrites 30-37 interleukin 1 beta Rattus norvegicus 52-70 9252565-6 1997 Nitrite production by rat aortic macrovascular endothelial cells (RAEC) was significantly greater than that by the rat lung microvascular endothelial cells (RLMVEC) when stimulated with TNF-alpha + IFN-gamma, LPS + IFN-gamma, or TNF-alpha + LPS. Nitrites 0-7 interferon gamma Rattus norvegicus 198-207 9252565-6 1997 Nitrite production by rat aortic macrovascular endothelial cells (RAEC) was significantly greater than that by the rat lung microvascular endothelial cells (RLMVEC) when stimulated with TNF-alpha + IFN-gamma, LPS + IFN-gamma, or TNF-alpha + LPS. Nitrites 0-7 interferon gamma Rattus norvegicus 215-224 9252565-6 1997 Nitrite production by rat aortic macrovascular endothelial cells (RAEC) was significantly greater than that by the rat lung microvascular endothelial cells (RLMVEC) when stimulated with TNF-alpha + IFN-gamma, LPS + IFN-gamma, or TNF-alpha + LPS. Nitrites 0-7 tumor necrosis factor Rattus norvegicus 229-238 9252565-8 1997 The nitrite generation from rat pulmonary artery endothelial cells was intermediate between RAEC and RLMVEC responses when stimulated with IFN-gamma + LPS or TNF-alpha. Nitrites 4-11 interferon gamma Rattus norvegicus 139-148 9252565-8 1997 The nitrite generation from rat pulmonary artery endothelial cells was intermediate between RAEC and RLMVEC responses when stimulated with IFN-gamma + LPS or TNF-alpha. Nitrites 4-11 tumor necrosis factor Rattus norvegicus 158-167 9302361-4 1997 RESULTS: Incubation of cultures with interleukin-1 beta (10 ng/ml) for 24 h caused a significant increase in nitrite production. Nitrites 109-116 interleukin 1 beta Rattus norvegicus 37-55 9302361-5 1997 The interleukin-1 beta-induced nitrite production by vascular smooth muscle cells was significantly increased by adenosine or its stable analogue, 2-chloroadenosine, in a dose-dependent manner. Nitrites 31-38 interleukin 1 beta Rattus norvegicus 4-22 9302361-6 1997 The adenosine A2a receptor antagonist, KF17837, but not the A1 receptor antagonist, DPCPX, significantly inhibited 2-chloroadenosine-mediated nitrite production. Nitrites 142-149 adenosine A2a receptor Rattus norvegicus 4-26 9302361-7 1997 The 2-chloroadenosine-mediated nitrite production by interleukin-1 beta-stimulated cells was accompanied by increased inducible NO synthase mRNA accumulation. Nitrites 31-38 interleukin 1 beta Rattus norvegicus 53-71 9302361-7 1997 The 2-chloroadenosine-mediated nitrite production by interleukin-1 beta-stimulated cells was accompanied by increased inducible NO synthase mRNA accumulation. Nitrites 31-38 nitric oxide synthase 2 Rattus norvegicus 118-139 9302361-8 1997 In the presence of dibutyryl-cAMP (1 mM), interleukin-1 beta-induced nitrite accumulation was further increased, but the effect of 2-chloroadenosine was not additive or synergistic. Nitrites 69-76 interleukin 1 beta Rattus norvegicus 42-60 9191464-9 1997 Cell cultures treated with TNF alpha/IFN gamma/LPS in combination expressed iNOS mRNA, and this was associated with increases in supernatant nitrite concentrations over 24 h; however, this response diminished with successive passage of cells. Nitrites 141-148 tumor necrosis factor Homo sapiens 27-36 9201027-6 1997 Production of NO metabolites (nitrate and nitrite), measured as their coronary arteriovenous differencexCBF, was significantly increased after 1 to 2 days of CAR, both at baseline (153 +/- 56%) and during BK infusion (220 +/- 76%) (P < .05). Nitrites 42-49 kininogen 1 Canis lupus familiaris 205-207 9191464-9 1997 Cell cultures treated with TNF alpha/IFN gamma/LPS in combination expressed iNOS mRNA, and this was associated with increases in supernatant nitrite concentrations over 24 h; however, this response diminished with successive passage of cells. Nitrites 141-148 interferon gamma Homo sapiens 37-46 9191464-9 1997 Cell cultures treated with TNF alpha/IFN gamma/LPS in combination expressed iNOS mRNA, and this was associated with increases in supernatant nitrite concentrations over 24 h; however, this response diminished with successive passage of cells. Nitrites 141-148 nitric oxide synthase 2 Homo sapiens 76-80 9174292-5 1997 The resultant iNOS expression was measured by using Northern blot analysis and cell supernatant nitrite concentrations (in aqueous media, NO is oxidized primarily to nitrite, NO2-) by chemiluminescence. Nitrites 96-103 nitric oxide synthase 2, inducible Mus musculus 14-18 9174292-5 1997 The resultant iNOS expression was measured by using Northern blot analysis and cell supernatant nitrite concentrations (in aqueous media, NO is oxidized primarily to nitrite, NO2-) by chemiluminescence. Nitrites 166-173 nitric oxide synthase 2, inducible Mus musculus 14-18 9182711-0 1997 pH-dependence for binding a single nitrite ion to each type-2 copper centre in the copper-containing nitrite reductase of Alcaligenes xylosoxidans. Nitrites 35-42 nitrite reductase large subunit Achromobacter xylosoxidans 101-118 9227507-6 1997 In the current study, we demonstrate that L2 cells generate the oxidative products of NO., nitrite and nitrate, after exposure to tumor necrosis factor-alpha, lipopolysaccharide, and interferon-gamma. Nitrites 91-98 tumor necrosis factor Rattus norvegicus 130-157 9227507-6 1997 In the current study, we demonstrate that L2 cells generate the oxidative products of NO., nitrite and nitrate, after exposure to tumor necrosis factor-alpha, lipopolysaccharide, and interferon-gamma. Nitrites 91-98 interferon gamma Rattus norvegicus 183-199 9210623-9 1997 The concentration of nitrites in the hepatocyte supernatant rose from 14.70+/-3.55 micromol x l(-1) to 150.50+/-45.55 micromol x l(-1) in the presence of a combination of interleukin-1beta, TNF alpha and interferon gamma. Nitrites 21-29 interleukin 1 beta Rattus norvegicus 171-188 9192093-3 1997 High levels of nitrite (40-70 nM) were detected in IFN-gamma and LPS activated, infected murine cell culture supernatants, however, NO2- titres produced by infected murine cells did not differ between various catalase phenotype strains. Nitrites 15-22 interferon gamma Mus musculus 51-60 10851463-5 1997 Functional iNOS protein expression was confirmed by bioassay of nitrite accumulation in the culture supernatant. Nitrites 64-71 nitric oxide synthase 2, inducible Mus musculus 11-15 9225020-9 1997 It is concluded that nitrite decreases blood pressure in rats, which probably induces, by renin-angiotensin system activation, hypertrophy of the adrenal zona glomerulosa. Nitrites 21-28 renin Rattus norvegicus 90-95 9218182-9 1997 RESULTS: AVP inhibited IL-1 beta-induced nitrite production in a dose- and time-dependent manner with concomitant changes in intracellular cGMP contents. Nitrites 41-48 arginine vasopressin Rattus norvegicus 9-12 9218182-9 1997 RESULTS: AVP inhibited IL-1 beta-induced nitrite production in a dose- and time-dependent manner with concomitant changes in intracellular cGMP contents. Nitrites 41-48 interleukin 1 beta Rattus norvegicus 23-32 9210623-9 1997 The concentration of nitrites in the hepatocyte supernatant rose from 14.70+/-3.55 micromol x l(-1) to 150.50+/-45.55 micromol x l(-1) in the presence of a combination of interleukin-1beta, TNF alpha and interferon gamma. Nitrites 21-29 tumor necrosis factor Rattus norvegicus 190-199 9234372-6 1997 Incubation of RMG cells and microglia with the stereoselective inhibitor of NOS, NG-monomethyl-L-arginine (L-NMMA), inhibited nitrite release in LPS + IFN-gamma-stimulated RMG cells and microglia. Nitrites 126-133 interferon gamma Rattus norvegicus 151-160 9218182-11 1997 Inhibition of nitrite and cGMP production by AVP was reversed by administration of the specific V1 receptor antagonist [1-(beta-mercapto-beta,beta- cyclopentamethylene propionic acid), 2-(O-methyl)-tyrosine] -Arg8-vasopressin) but not by the oxytocin (OXT) receptor antagonist [d(CH2(5)), TyrMe2, Orn8]-Vasotocin. Nitrites 14-21 arginine vasopressin Rattus norvegicus 45-48 9234375-6 1997 The addition of TNF in the culture medium containing LPS/IFN-gamma further increases nitrite production in C3H/HeN RMG cells and allows the synthesis of low levels of nitrite in C3H/HeJ RMG cells. Nitrites 85-92 tumor necrosis factor Mus musculus 16-19 9234375-6 1997 The addition of TNF in the culture medium containing LPS/IFN-gamma further increases nitrite production in C3H/HeN RMG cells and allows the synthesis of low levels of nitrite in C3H/HeJ RMG cells. Nitrites 85-92 toll-like receptor 4 Mus musculus 53-56 9234375-6 1997 The addition of TNF in the culture medium containing LPS/IFN-gamma further increases nitrite production in C3H/HeN RMG cells and allows the synthesis of low levels of nitrite in C3H/HeJ RMG cells. Nitrites 85-92 interferon gamma Mus musculus 57-66 9234375-6 1997 The addition of TNF in the culture medium containing LPS/IFN-gamma further increases nitrite production in C3H/HeN RMG cells and allows the synthesis of low levels of nitrite in C3H/HeJ RMG cells. Nitrites 167-174 tumor necrosis factor Mus musculus 16-19 9234375-6 1997 The addition of TNF in the culture medium containing LPS/IFN-gamma further increases nitrite production in C3H/HeN RMG cells and allows the synthesis of low levels of nitrite in C3H/HeJ RMG cells. Nitrites 167-174 toll-like receptor 4 Mus musculus 53-56 9234375-6 1997 The addition of TNF in the culture medium containing LPS/IFN-gamma further increases nitrite production in C3H/HeN RMG cells and allows the synthesis of low levels of nitrite in C3H/HeJ RMG cells. Nitrites 167-174 interferon gamma Mus musculus 57-66 9153221-1 1997 The purpose of this study was to evaluate the effects of interferon-gamma (IFN-gamma) alone and in combination with interleukin 1beta (IL-1beta) on inducible nitric-oxide synthase (iNOS) mRNA and protein expression, nitrite production, and insulin secretion by islets of Langerhans. Nitrites 216-223 interleukin 1 beta Rattus norvegicus 135-143 9153192-5 1997 This superinduction of NOS-2 protein by pretreatment with GGTI-298 resulted in nitrite concentrations in the medium that were 5-fold higher at 10 ng/ml IL-1beta and 10-fold higher at 1 ng/ml IL-1beta. Nitrites 79-86 nitric oxide synthase 2 Rattus norvegicus 23-28 9153192-5 1997 This superinduction of NOS-2 protein by pretreatment with GGTI-298 resulted in nitrite concentrations in the medium that were 5-fold higher at 10 ng/ml IL-1beta and 10-fold higher at 1 ng/ml IL-1beta. Nitrites 79-86 interleukin 1 beta Rattus norvegicus 152-160 9153221-1 1997 The purpose of this study was to evaluate the effects of interferon-gamma (IFN-gamma) alone and in combination with interleukin 1beta (IL-1beta) on inducible nitric-oxide synthase (iNOS) mRNA and protein expression, nitrite production, and insulin secretion by islets of Langerhans. Nitrites 216-223 nitric oxide synthase 2 Rattus norvegicus 181-185 9153192-5 1997 This superinduction of NOS-2 protein by pretreatment with GGTI-298 resulted in nitrite concentrations in the medium that were 5-fold higher at 10 ng/ml IL-1beta and 10-fold higher at 1 ng/ml IL-1beta. Nitrites 79-86 angiotensin II receptor, type 1a Rattus norvegicus 140-144 9153221-2 1997 Treatment of rat islets with IL-1beta results in a concentration-dependent increase in the production of nitrite that is maximal at 5 units/ml. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 29-37 9153221-6 1997 iNOS expression and nitrite production by rat islets in response to 150 units/ml rat IFN-gamma and 0.1 unit/ml IL-1beta are correlated with an inhibition of insulin secretion and islet degeneration that are prevented by the iNOS inhibitor aminoguanidine. Nitrites 20-27 interferon gamma Rattus norvegicus 85-94 9153221-8 1997 Last, cellular damage during physical dispersion of islets results in the release of sufficient amounts of IL-1beta to induce iNOS expression and nitrite production in the presence of exogenously added rat IFN-gamma. Nitrites 146-153 interleukin 1 beta Rattus norvegicus 107-115 9153221-9 1997 The cellular source of IL-1beta under these conditions is believed to be resident islet macrophages as depletion of macrophages prior to dispersion prevents IFN-gamma-induced iNOS expression and nitrite formation by dispersed islet cells. Nitrites 195-202 interleukin 1 beta Rattus norvegicus 23-31 9153221-6 1997 iNOS expression and nitrite production by rat islets in response to 150 units/ml rat IFN-gamma and 0.1 unit/ml IL-1beta are correlated with an inhibition of insulin secretion and islet degeneration that are prevented by the iNOS inhibitor aminoguanidine. Nitrites 20-27 interleukin 1 beta Rattus norvegicus 111-119 9153221-10 1997 These studies show that the T-lymphocyte cytokine, IFN-gamma, increases the sensitivity of rat islets to the effects of IL-1beta on iNOS expression and nitrite production by 10-fold, in part, through the stabilization of iNOS mRNA. Nitrites 152-159 interferon gamma Rattus norvegicus 51-60 9151903-7 1997 Nitrite production and cytokine secretion (IL-1, IL-6, and TNF-alpha) are normal or even enhanced in hck-/-fgr-/-lyn-/- macrophages after LPS stimulation. Nitrites 0-7 hemopoietic cell kinase Mus musculus 101-104 9153221-10 1997 These studies show that the T-lymphocyte cytokine, IFN-gamma, increases the sensitivity of rat islets to the effects of IL-1beta on iNOS expression and nitrite production by 10-fold, in part, through the stabilization of iNOS mRNA. Nitrites 152-159 interleukin 1 beta Rattus norvegicus 120-128 9151903-7 1997 Nitrite production and cytokine secretion (IL-1, IL-6, and TNF-alpha) are normal or even enhanced in hck-/-fgr-/-lyn-/- macrophages after LPS stimulation. Nitrites 0-7 FGR proto-oncogene, Src family tyrosine kinase Mus musculus 107-110 9176264-4 1997 PAEM were incubated with TNF-alpha (100 U/ml) for 4 h. Incubation of PAEM with TNF-alpha resulted in increases in 1) the .NO oxidation product nitrite (NO2-), 2) nitrotyrosine immunofluorescence, 3) the oxidation of p42 (tentatively identified as actin), and 4) permeability to Evans blue dye-albumin. Nitrites 143-150 tumor necrosis factor Homo sapiens 25-34 9139718-11 1997 Inhibition of the PtdIns 3-kinase activity was paralleled by a reversal of the ability of IL-13 to inhibit iNOS mRNA expression and nitrite generation in HT-29 cells. Nitrites 132-139 interleukin 13 Homo sapiens 90-95 9175517-6 1997 Preincubation of T. spiralis L1 larvae with nitrite also caused an increase in the number of CD4(+) and CD8(+) cells as well as IL-2, IL-5, and INF-gamma levels. Nitrites 44-51 CD4 antigen Mus musculus 93-96 9175517-6 1997 Preincubation of T. spiralis L1 larvae with nitrite also caused an increase in the number of CD4(+) and CD8(+) cells as well as IL-2, IL-5, and INF-gamma levels. Nitrites 44-51 interleukin 2 Mus musculus 128-132 9175517-6 1997 Preincubation of T. spiralis L1 larvae with nitrite also caused an increase in the number of CD4(+) and CD8(+) cells as well as IL-2, IL-5, and INF-gamma levels. Nitrites 44-51 interleukin 5 Mus musculus 134-138 9175517-7 1997 An increased level of CD8(+) subsets and a depression of IL-2 and IL-5 production by MLNC were observed in mice infected with larvae without nitrite pretreatment. Nitrites 141-148 interleukin 2 Mus musculus 57-61 9175517-7 1997 An increased level of CD8(+) subsets and a depression of IL-2 and IL-5 production by MLNC were observed in mice infected with larvae without nitrite pretreatment. Nitrites 141-148 interleukin 5 Mus musculus 66-70 9176264-4 1997 PAEM were incubated with TNF-alpha (100 U/ml) for 4 h. Incubation of PAEM with TNF-alpha resulted in increases in 1) the .NO oxidation product nitrite (NO2-), 2) nitrotyrosine immunofluorescence, 3) the oxidation of p42 (tentatively identified as actin), and 4) permeability to Evans blue dye-albumin. Nitrites 143-150 tumor necrosis factor Homo sapiens 79-88 9146896-16 1997 Similarly, segments of rat aorta released detectable levels of nitrite and nitrate, which were reduced by NG-nitro-L-arginine methyl ester (L-NAME, 1 mM), which inhibits all isoforms of NOS, and by dexamethasone (1 microM), which inhibits the induction of iNOS. Nitrites 63-70 nitric oxide synthase 2 Rattus norvegicus 256-260 9145305-2 1997 We have demonstrated here that retinal Muller glial (RMG) cells obtained from RCS dystrophic rats and stimulated in vitro with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) accumulated higher levels of tumor necrosis factor (TNF) and inducible nitric oxide synthase (NOS II) mRNA and released in culture supernatants significantly higher amounts of TNF and nitrite compared to cells derived from nondystrophic controls. Nitrites 369-376 interferon gamma Rattus norvegicus 156-172 9145305-2 1997 We have demonstrated here that retinal Muller glial (RMG) cells obtained from RCS dystrophic rats and stimulated in vitro with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) accumulated higher levels of tumor necrosis factor (TNF) and inducible nitric oxide synthase (NOS II) mRNA and released in culture supernatants significantly higher amounts of TNF and nitrite compared to cells derived from nondystrophic controls. Nitrites 369-376 interferon gamma Rattus norvegicus 174-183 9145305-3 1997 The TNF and NOS II mRNA expression and TNF and nitrite synthesis induced in RMG cells from both strains by LPS + IFN-gamma was significantly prevented by including transforming growth factor-beta (TGF-beta) in the culture medium. Nitrites 47-54 interferon gamma Rattus norvegicus 113-122 9133470-4 1997 iNOS expression in allografts resulted in elevated serum nitrite/nitrate levels, indicative of increased in vivo nitric oxide (NO) production. Nitrites 57-64 nitric oxide synthase 2 Rattus norvegicus 0-4 9195135-6 1997 IL-1 beta caused a more than 10-fold increase in medium nitrite production, an indication of nitric oxide production, which was blocked by S-methyl-L-thiocitrulline. Nitrites 56-63 interleukin 1 beta Mus musculus 0-9 9195135-8 1997 The efficacy of S-methyl-L-thiocitrulline, NG-monomethyl-L-arginine and aminoguanidine in counteracting IL-1 beta induced nitrite formation was also compared. Nitrites 122-129 interleukin 1 beta Mus musculus 104-113 9226398-2 1997 In the present study, hepatic macrophages obtained from male rats were treated in vitro with somatostatin or octreotide and their effects on the release of nitrite, tumor necrosis factor (TNF), and hydrogen peroxide (H2O2) determined. Nitrites 156-163 somatostatin Rattus norvegicus 93-105 9226398-3 1997 At concentrations of 10(-14) M to 10(-12) M, or greater than 10(-10) M, somatostatin suppressed nitrite release by Kupffer cells. Nitrites 96-103 somatostatin Rattus norvegicus 72-84 9133470-8 1997 CONCLUSIONS: (1) iNOS expression and increased NO production occurred during the early stages of acute rejection, persisted throughout the unmodified rejection process, and localized to infiltrating inflammatory cells, but not allograft parenchymal cells; (2) aminoguanidine ameliorated the histological and functional changes of acute rejection; and (3) increased NO production, detected by the presence of iNOS mRNA, protein, or noninvasively by measuring serum nitrite/nitrate levels, may serve as an early marker of acute allograft rejection. Nitrites 464-471 nitric oxide synthase 2 Rattus norvegicus 17-21 9103445-8 1997 It was also observed that nitrite release by IFN-gamma-primed macrophages activated with LPS (1-100 ng/ml) was 20 times lower than that induced by IFN-gamma + BTp20. Nitrites 26-33 interferon gamma Mus musculus 45-54 9144574-5 1997 Sin-1 induced 4-fold higher levels of cellular nitrite than that generated by the chemical in cell free medium. Nitrites 47-54 MAPK associated protein 1 Homo sapiens 0-5 9108779-4 1997 Exposure of cultured SMCs to IL-1 beta increased NF-kappa B binding activity within 30 minutes and was associated with nitrite accumulation and the appearance of iNOS protein 24 hours later. Nitrites 119-126 interleukin 1 beta Rattus norvegicus 29-38 9175238-7 1997 An inverse correlation of nitrate/nitrite excretion with endothelial markers (von Willebrand factor, soluble thrombomodulin) was documented in NIDDM, this correlation was much stronger in IDDM. Nitrites 34-41 thrombomodulin Homo sapiens 109-123 9175238-8 1997 Moreover, in IDDM patients reduced nitrate/nitrite excretion was strongly associated with elevated plasmatic beta-thromboglobulin levels. Nitrites 43-50 pro-platelet basic protein Homo sapiens 109-129 9175238-10 1997 In IDDM the decreased nitrate/nitrite excretion may also lead to increased in vivo platelet activation, which suggests that the reduced amount of EDRF-NO might play a role in the pathogenesis of angiopathy in IDDM. Nitrites 30-37 alpha hemoglobin stabilizing protein Homo sapiens 146-150 9109387-2 1997 A 9-h irradiation with polychromatic visible light increased the formation of nitrite (NO index metabolite) from SIN-1 (1 mM) by 61% as compared to control samples incubated in the dark. Nitrites 78-85 MAPK associated protein 1 Homo sapiens 113-118 9103544-2 1997 Ethanol dose-dependently inhibits C6 cell NOS-2 activity, as measured by nitrite accumulation in culture medium, when present during LPS plus PMA treatment. Nitrites 73-80 nitric oxide synthase 2 Homo sapiens 42-47 10495784-4 1997 Coincubation of cells with 10(-9)-10(-6) M ANG II attenuated this LPS/gamma-IF-stimulated induction of nitrite. Nitrites 103-110 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 43-49 9110418-5 1997 Similarly, LPS-induced production of nitrite/nitrate (breakdown products of nitric oxide) was not affected by verapamil and diltiazem. Nitrites 37-44 toll-like receptor 4 Mus musculus 11-14 9701055-3 1997 Induction of nitric oxide synthase (NOS-2) expression in C6-hsp70 cells, assessed by nitrite accumulation, was significantly reduced compared to control C6-pTK cells (25+/-8% of control cell induction, P < 0.005), when induced with a maximally stimulatory combination of bacterial endotoxin lipopolysaccharide (LPS) plus a mixture of three cytokines ("CM:" TNF-alpha, IL1-beta, and IFN-gamma). Nitrites 85-92 nitric oxide synthase 2 Homo sapiens 36-41 9701055-3 1997 Induction of nitric oxide synthase (NOS-2) expression in C6-hsp70 cells, assessed by nitrite accumulation, was significantly reduced compared to control C6-pTK cells (25+/-8% of control cell induction, P < 0.005), when induced with a maximally stimulatory combination of bacterial endotoxin lipopolysaccharide (LPS) plus a mixture of three cytokines ("CM:" TNF-alpha, IL1-beta, and IFN-gamma). Nitrites 85-92 heat shock protein family A (Hsp70) member 4 Homo sapiens 60-65 9161026-1 1997 Higher plant nitrite reductase (NiR) is a monomeric chloroplastic protein catalysing the reduction of nitrite, the product of nitrate reduction, to ammonium. Nitrites 13-20 nitrite reductase 1 Arabidopsis thaliana 32-35 9126339-9 1997 Furthermore, NG-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, significantly decreased IFN-gamma induced elevations in medium levels of Epo and nitrite as well as cGMP levels in Hep3B cells. Nitrites 163-170 interferon gamma Homo sapiens 106-115 9126339-7 1997 IFN-gamma produced significant increases in medium levels of Epo and nitrite. Nitrites 69-76 interferon gamma Homo sapiens 0-9 9065411-5 1997 In addition, the effect of MIX is also observed by measuring nitrite, the stable breakdown product of NO: a 30-min pretreatment of T67 cells with MIX is able to reduce significantly the N-methyl-D-aspartate-induced nitrite production. Nitrites 61-68 Mix paired-like homeobox Homo sapiens 27-30 9065411-5 1997 In addition, the effect of MIX is also observed by measuring nitrite, the stable breakdown product of NO: a 30-min pretreatment of T67 cells with MIX is able to reduce significantly the N-methyl-D-aspartate-induced nitrite production. Nitrites 61-68 Mix paired-like homeobox Homo sapiens 146-149 9065411-5 1997 In addition, the effect of MIX is also observed by measuring nitrite, the stable breakdown product of NO: a 30-min pretreatment of T67 cells with MIX is able to reduce significantly the N-methyl-D-aspartate-induced nitrite production. Nitrites 215-222 Mix paired-like homeobox Homo sapiens 27-30 9065411-5 1997 In addition, the effect of MIX is also observed by measuring nitrite, the stable breakdown product of NO: a 30-min pretreatment of T67 cells with MIX is able to reduce significantly the N-methyl-D-aspartate-induced nitrite production. Nitrites 215-222 Mix paired-like homeobox Homo sapiens 146-149 9085046-0 1997 Interleukin-6 increases the levels of cyclic GMP and nitrite in rat hippocampal slices. Nitrites 53-60 interleukin 6 Rattus norvegicus 0-13 9085046-1 1997 We examined the effect of interleukin-6 on the levels of cGMP and nitrite in rat hippocampal slices. Nitrites 66-73 interleukin 6 Rattus norvegicus 26-39 9085046-3 1997 In addition, exposure of slices to interleukin-6 at 80, 400 and 2000 ng/ml or at 16, 80 and 400 ng/ml for 2 h significantly elevated the cGMP level and nitrite level, respectively, in a concentration-dependent manner. Nitrites 152-159 interleukin 6 Rattus norvegicus 35-48 9085046-5 1997 However when incubated in conjunction with 400 ng/ml interleukin-6 for 2 h, NG-nitro-L-arginine apparently prevented the increase in cGMP and nitrite induced by 400 ng/ml interleukin-6. Nitrites 142-149 interleukin 6 Rattus norvegicus 53-66 9085046-5 1997 However when incubated in conjunction with 400 ng/ml interleukin-6 for 2 h, NG-nitro-L-arginine apparently prevented the increase in cGMP and nitrite induced by 400 ng/ml interleukin-6. Nitrites 142-149 interleukin 6 Rattus norvegicus 171-184 21639224-5 1997 According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current. Nitrites 183-190 mitochondrially encoded cytochrome c oxidase II Homo sapiens 56-62 21639224-5 1997 According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current. Nitrites 183-190 mitochondrially encoded cytochrome c oxidase III Homo sapiens 78-85 21639224-5 1997 According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current. Nitrites 150-157 mitochondrially encoded cytochrome c oxidase II Homo sapiens 56-62 21639224-5 1997 According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current. Nitrites 183-190 mitochondrially encoded cytochrome c oxidase III Homo sapiens 81-84 21639224-5 1997 According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current. Nitrites 150-157 mitochondrially encoded cytochrome c oxidase III Homo sapiens 78-85 21639224-5 1997 According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current. Nitrites 150-157 mitochondrially encoded cytochrome c oxidase III Homo sapiens 81-84 21639224-5 1997 According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current. Nitrites 183-190 mitochondrially encoded cytochrome c oxidase III Homo sapiens 167-174 21639224-5 1997 According to the proposed reaction mechanism, dissolved Co(II) is oxidized to Co(III) upon addition of nioxime and high concentrations of ammonia and nitrite; a mixed Co(III)-ammonia-nitrite complex is adsorbed on the electrode surface; the Co(III) is reduced to Co(II) (complexed by nioxime) during the voltammetric scan, followed by its chemical reoxidation by the nitrite, initiating a catalytically enhanced current. Nitrites 183-190 mitochondrially encoded cytochrome c oxidase II Homo sapiens 263-269 9065390-4 1997 The transformants carrying nit1/ars did not express arylsulphatase when grown in ammonium-sufficient medium but readily accumulated the enzyme in ammonium-free medium either supplemented, or not supplemented, with nitrate or nitrite. Nitrites 225-232 uncharacterized protein Chlamydomonas reinhardtii 27-31 9137773-3 1997 Two fluorimetric methods have been described for the quantitative determination of RDX which are based on the detection of nitrite ions. Nitrites 123-130 radixin Homo sapiens 83-86 9137773-4 1997 After a basic decomposition of RDX the nitrite ion can be detected by reaction with 4-aminofluorescein and by reactions forming a lumogallion-gallium(III) complex. Nitrites 39-46 radixin Homo sapiens 31-34 9104557-5 1997 In contrast, chondrocytes treated with LPS or IL-1 beta synthesised nitrite in a dose-related manner. Nitrites 68-75 interleukin-1 beta Equus caballus 46-55 9373392-3 1997 Using RBC transformed by conversion of intracellular hemoglobin to methemoglobin with nitrite as the oxidizing agent, a concomitant modification of cytosolic rheological properties was achieved by the same HT procedure. Nitrites 86-93 hemoglobin subunit gamma 2 Homo sapiens 67-80 9063726-5 1997 Production of IL-1 beta and NO was determined by measurement of IL-1 beta and nitrite concentrations in cell lysates and the culture medium, respectively. Nitrites 78-85 interleukin 1 beta Rattus norvegicus 14-23 9104557-7 1997 Dexamethasone, an inhibitor of induction of the inducible isoform of NOS (iNOS), reduced nitrite synthesis by LPS-stimulated chondrocytes. Nitrites 89-96 nitric oxide synthase 2 Equus caballus 74-78 9087877-7 1997 CONCLUSIONS: These results, together with our previous demonstration that iNOS inhibition ameliorated lung allograft rejection, suggest that (1) iNOS expression and increased NO production contributed to acute rejection of the transplanted lung, (2) iNOS inhibition may offer an alternative in management of acute lung allograft rejection, and (3) increased NO production, detected by the presence of iNOS mRNA or protein or noninvasively by measuring serum nitrite/nitrate levels, may serve as an early marker of acute allograft rejection. Nitrites 458-465 nitric oxide synthase 2 Rattus norvegicus 74-78 10325618-0 1997 [The method to remove nitrite from tap water by tea]. Nitrites 22-29 SEC14 like lipid binding 2 Homo sapiens 35-38 9235225-3 1997 Substitution of the culture medium of rat peritoneal macrophages at pH 7.4 with medium at pH 7.0 upregulated iNOS activity, as reflected by a 2.5-fold increase in nitrite accumulation. Nitrites 163-170 nitric oxide synthase 2 Rattus norvegicus 109-113 9059850-6 1997 Only interleukin-1 beta treatment resulted in significant nitrite production, immunohistochemical staining for inducible nitric oxide synthase and detection of inducible NO synthase messenger RNA by reverse transcriptase-polymerase chain reaction (RT-PCR). Nitrites 58-65 interleukin 1 beta Homo sapiens 5-23 9235225-5 1997 Low environmental pH-induced iNOS gene expression involved the activation of nuclear factor-kappa B (NF-kappa B) transcription factor since [1] exposure of macrophages to low environmental pH increased NF-kappa B binding activity in the nucleus, and [2] treatment of macrophages with pyrrolidine dithiocarbamate or n-acetyl-leucinyl-norleucinal, two drugs preventing NF-kappa B translocation to the nucleus, canceled low pH-induced nitrite accumulation. Nitrites 432-439 nitric oxide synthase 2 Rattus norvegicus 29-33 9235225-7 1997 Indeed, [1] elevated TNF-alpha bioactivity was observed in the medium of macrophages exposed to pH 7.0, and [2] incubation of macrophages with a neutralizing anti-TNF-alpha antibody impaired both NF-kappa B activation and nitrite accumulation in response to acid challenge. Nitrites 222-229 tumor necrosis factor Rattus norvegicus 21-30 9235225-7 1997 Indeed, [1] elevated TNF-alpha bioactivity was observed in the medium of macrophages exposed to pH 7.0, and [2] incubation of macrophages with a neutralizing anti-TNF-alpha antibody impaired both NF-kappa B activation and nitrite accumulation in response to acid challenge. Nitrites 222-229 tumor necrosis factor Rattus norvegicus 163-172 9020872-4 1997 Northern-blot analysis showed that YNT1 is expressed when the yeast is grown in nitrate and nitrite but not in ammonium solution. Nitrites 92-99 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 35-39 9021956-3 1997 We have previously reported that, in cultured rat hepatocytes, a single cytokine interleukin-1beta (IL-1beta) stimulated a release of nitrite, an oxidation product of NO, into culture medium dose- and time-dependently. Nitrites 134-141 interleukin 1 beta Rattus norvegicus 81-98 9021956-3 1997 We have previously reported that, in cultured rat hepatocytes, a single cytokine interleukin-1beta (IL-1beta) stimulated a release of nitrite, an oxidation product of NO, into culture medium dose- and time-dependently. Nitrites 134-141 interleukin 1 beta Rattus norvegicus 100-108 9193655-4 1997 We found that inhibitors of ADP-ribosylation inhibited nitrite synthesis in RAW 264.7 macrophages after stimulation by IFN-gamma and LPS. Nitrites 55-62 interferon gamma Mus musculus 119-128 8993009-5 1997 PGE2 and cholera toxin increased the production of nitrite (an indicator of nitric oxide production) in IFN-gamma-treated ANA-1 macrophages by at least twofold. Nitrites 51-58 interferon gamma Mus musculus 104-113 9001323-6 1997 Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956). Nitrites 56-63 tumor necrosis factor Mus musculus 14-17 9001323-6 1997 Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956). Nitrites 56-63 interleukin 1 complex Mus musculus 25-29 9001323-6 1997 Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956). Nitrites 67-74 tumor necrosis factor Mus musculus 14-17 9001323-6 1997 Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956). Nitrites 67-74 interleukin 1 complex Mus musculus 25-29 9001323-6 1997 Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956). Nitrites 67-74 tumor necrosis factor Mus musculus 14-17 9001323-6 1997 Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956). Nitrites 67-74 interleukin 1 complex Mus musculus 25-29 9038808-3 1997 In L6 cells, the combination of interleukin-1 beta and interferon-gamma induced a marked accumulation of nitrite, a stable metabolite of nitric oxide. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 32-50 9038808-3 1997 In L6 cells, the combination of interleukin-1 beta and interferon-gamma induced a marked accumulation of nitrite, a stable metabolite of nitric oxide. Nitrites 105-112 interferon gamma Rattus norvegicus 55-71 9038920-4 1997 Nitrite concentration in the medium and intracellular guanosine 3",5"-cyclic monophosphate (cGMP) contents after 24-h exposure to LPS increased in proportion to the levels of iNOS induction in these cells. Nitrites 0-7 nitric oxide synthase 2 Rattus norvegicus 175-179 9512892-2 1997 Therefore, study of the reaction of nitrite with elastin in vitro was undertaken. Nitrites 36-43 elastin Homo sapiens 49-56 9010260-3 1997 MC isolated from rat glomeruli generated substantial amounts of nitrite, the stable NO end-product, when cells were stimulated with IL-1beta and tumour necrosis factor-alpha (TNF-alpha). Nitrites 64-71 interleukin 1 beta Rattus norvegicus 132-140 9010260-3 1997 MC isolated from rat glomeruli generated substantial amounts of nitrite, the stable NO end-product, when cells were stimulated with IL-1beta and tumour necrosis factor-alpha (TNF-alpha). Nitrites 64-71 tumor necrosis factor Rattus norvegicus 175-184 9010260-7 1997 Lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma), but not IL-1beta and TNF-alpha, induced rat peritoneal macrophages to produce large amounts of nitrite. Nitrites 154-161 interferon gamma Rattus norvegicus 29-45 9010260-7 1997 Lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma), but not IL-1beta and TNF-alpha, induced rat peritoneal macrophages to produce large amounts of nitrite. Nitrites 154-161 interferon gamma Rattus norvegicus 47-56 9512892-3 1997 By colorimetric assay, reactivity of nitrite with insoluble elastin at neutral pH, 37 degrees C, and physiologic concentration was confirmed. Nitrites 37-44 elastin Homo sapiens 60-67 9512892-4 1997 In histochemical studies on in situ human aortic elastin, nitrite-treated sections displayed marked structural disruptions. Nitrites 58-65 elastin Homo sapiens 49-56 9512892-5 1997 Determinations of fluorescence and absorbance on nitrite-treated soluble bovine elastin revealed marked alterations of fluorescence, and increased UV and visible absorbance. Nitrites 49-56 elastin Bos taurus 80-87 9512892-7 1997 The findings indicate that non-enzymatic nitration by nitrite may have deleterious effects on elastin in vivo and may provide insights into the pathogenesis of chronic elastin degenerative processes, including aortic aneurysms, pulmonary emphysema, and premature skin wrinkling, all of which have been well known to have associations with cigarette smoking. Nitrites 54-61 elastin Homo sapiens 94-101 9512892-7 1997 The findings indicate that non-enzymatic nitration by nitrite may have deleterious effects on elastin in vivo and may provide insights into the pathogenesis of chronic elastin degenerative processes, including aortic aneurysms, pulmonary emphysema, and premature skin wrinkling, all of which have been well known to have associations with cigarette smoking. Nitrites 54-61 elastin Homo sapiens 168-175 9039082-3 1997 Incubation of the cultures with interleukin-1 beta (10 ng/mL) for 24 hours caused a significant increase in nitrite production. Nitrites 108-115 interleukin 1 beta Rattus norvegicus 32-50 9102099-0 1997 [The toxic effect of glutamate and nitrite on the cyclic GMP level in neurons and their viability]. Nitrites 35-42 5'-nucleotidase, cytosolic II Homo sapiens 57-60 9039082-4 1997 Endothelin-1 significantly decreased the interleukin-1 beta-induced nitrite production by vascular smooth muscle cells in a dose-dependent manner (10(-11) to 10(-8) mol/L). Nitrites 68-75 endothelin 1 Rattus norvegicus 0-12 9039082-4 1997 Endothelin-1 significantly decreased the interleukin-1 beta-induced nitrite production by vascular smooth muscle cells in a dose-dependent manner (10(-11) to 10(-8) mol/L). Nitrites 68-75 interleukin 1 beta Rattus norvegicus 41-59 8985206-0 1997 Nitrite generation in interleukin-4-treated human macrophage cultures does not involve the nitric oxide synthase pathway. Nitrites 0-7 interleukin 4 Homo sapiens 22-35 8985206-2 1997 Recently, generation of nitrite in culture supernatants of human macrophages exposed to interferon-gamma and interleukin-4 (IFN-gamma/IL-4) was reported. Nitrites 24-31 interferon gamma Homo sapiens 88-104 8985206-2 1997 Recently, generation of nitrite in culture supernatants of human macrophages exposed to interferon-gamma and interleukin-4 (IFN-gamma/IL-4) was reported. Nitrites 24-31 interleukin 4 Homo sapiens 109-122 8985206-2 1997 Recently, generation of nitrite in culture supernatants of human macrophages exposed to interferon-gamma and interleukin-4 (IFN-gamma/IL-4) was reported. Nitrites 24-31 interferon gamma Homo sapiens 124-133 8985206-2 1997 Recently, generation of nitrite in culture supernatants of human macrophages exposed to interferon-gamma and interleukin-4 (IFN-gamma/IL-4) was reported. Nitrites 24-31 interleukin 4 Homo sapiens 134-138 8985206-8 1997 Nitrite accumulation in experiments with IFN-gamma/IL-4 in human monocytes appears to be an in vitro artifact produced by nitrate-reducing activities contained in cytokine preparations. Nitrites 0-7 interferon gamma Homo sapiens 41-50 8985206-8 1997 Nitrite accumulation in experiments with IFN-gamma/IL-4 in human monocytes appears to be an in vitro artifact produced by nitrate-reducing activities contained in cytokine preparations. Nitrites 0-7 interleukin 4 Homo sapiens 51-55 9010412-0 1997 A rostrocaudal gradient of nitrate plus nitrite concentrations in CSF. Nitrites 40-47 colony stimulating factor 2 Homo sapiens 66-69 9411502-3 1997 CSF nitrite and nitrate levels (the stable degradation product of NO) were determined by a modified Griess reaction. Nitrites 4-11 colony stimulating factor 2 Homo sapiens 0-3 9411502-4 1997 The mean +/- levels of nitrite and nitrate in CSF on admission were higher in patients with BM in comparison with controls and in children with viral meningitis. Nitrites 23-30 colony stimulating factor 2 Homo sapiens 46-49 9411502-6 1997 At 24 to 48 hours those who received dexamethasone therapy had a significantly lower mean +/- SD CSF nitrite concentration compared with that in non-steroid treated patients. Nitrites 101-108 colony stimulating factor 2 Homo sapiens 97-100 9411502-7 1997 In all patients with meningitis a significant positive correlation was found between CSF nitrite and CSF granulocyte counts and also CSF protein concentration. Nitrites 89-96 colony stimulating factor 2 Homo sapiens 85-88 9411502-7 1997 In all patients with meningitis a significant positive correlation was found between CSF nitrite and CSF granulocyte counts and also CSF protein concentration. Nitrites 89-96 colony stimulating factor 2 Homo sapiens 101-104 9411502-7 1997 In all patients with meningitis a significant positive correlation was found between CSF nitrite and CSF granulocyte counts and also CSF protein concentration. Nitrites 89-96 colony stimulating factor 2 Homo sapiens 101-104 8982730-5 1996 Induction of inducible NO synthase in mesangial cells by interleukin-1 beta leads to excessive formation of NO by the cells as measured by nitrite production. Nitrites 139-146 nitric oxide synthase 2 Homo sapiens 13-34 8986132-6 1996 Ebselen (20 microM) prevented the increase in nitrite production by rat islets exposed to IL-1 beta for 6 hr and induced significant protection against the acute inhibitory effects of alloxan or H2O2 exposure, as judged by the preserved glucose oxidation rates. Nitrites 46-53 interleukin 1 beta Rattus norvegicus 90-99 8982730-5 1996 Induction of inducible NO synthase in mesangial cells by interleukin-1 beta leads to excessive formation of NO by the cells as measured by nitrite production. Nitrites 139-146 interleukin 1 beta Homo sapiens 57-75 8986132-8 1996 Ebselen prevented the increase in nitrite production by human islets exposed for 14 hr to a combination of cytokines (IL-1 beta, tumor necrosis factor-alpha and interferon-gamma). Nitrites 34-41 interleukin 1 beta Homo sapiens 118-156 8986132-8 1996 Ebselen prevented the increase in nitrite production by human islets exposed for 14 hr to a combination of cytokines (IL-1 beta, tumor necrosis factor-alpha and interferon-gamma). Nitrites 34-41 interferon gamma Homo sapiens 161-177 8943052-4 1996 Similarly, minocycline > or = doxycycline inhibited both lipopolysaccharide- and interferon-gamma-stimulated iNOS in RAW 264.7 cells in vitro, as assessed by nitrite accumulation. Nitrites 161-168 interferon gamma Mus musculus 84-100 8980906-2 1996 Activation of the cells with lipopolysaccharide plus interferon-gamma (LI) induced iNOS, detected by nitrite or by labeled L-citrulline production and by a specific antibody against macrophage iNOS. Nitrites 101-108 interferon gamma Mus musculus 53-69 8980906-2 1996 Activation of the cells with lipopolysaccharide plus interferon-gamma (LI) induced iNOS, detected by nitrite or by labeled L-citrulline production and by a specific antibody against macrophage iNOS. Nitrites 101-108 nitric oxide synthase 2, inducible Mus musculus 83-87 8943431-12 1996 IL-10 suppressed the increase of nitrite concentration in cell culture supernatant of primary rat cerebral endothelial cells when stimulated with heat-killed pneumococci. Nitrites 33-40 interleukin 10 Rattus norvegicus 0-5 8943494-1 1996 Nitric oxide (NO) is readily oxidized to nitrate and nitrite and NO activates guanylyl cyclase, increasing cyclic GMP levels. Nitrites 53-60 5'-nucleotidase, cytosolic II Homo sapiens 114-117 8921801-5 1996 Incubation of the cultures with interleukin-1 beta (10 ng/mL) for 24 hours caused a significant increase in nitrite accumulation. Nitrites 108-115 interleukin 1 beta Homo sapiens 32-50 8921801-6 1996 Adrenomedullin significantly augmented nitrite production by interleukin-1 beta-stimulated but not by unstimulated cardiac myocytes in a dose-dependent manner (10(-10) to 10(-6) mol/L). Nitrites 39-46 adrenomedullin Homo sapiens 0-14 8921801-6 1996 Adrenomedullin significantly augmented nitrite production by interleukin-1 beta-stimulated but not by unstimulated cardiac myocytes in a dose-dependent manner (10(-10) to 10(-6) mol/L). Nitrites 39-46 interleukin 1 beta Homo sapiens 61-79 8921801-7 1996 The adrenomedullin-induced nitrite production by interleukin-1 beta-stimulated cells was accompanied by increased inducible NO synthase mRNA and protein expression. Nitrites 27-34 adrenomedullin Homo sapiens 4-18 8921801-7 1996 The adrenomedullin-induced nitrite production by interleukin-1 beta-stimulated cells was accompanied by increased inducible NO synthase mRNA and protein expression. Nitrites 27-34 interleukin 1 beta Homo sapiens 49-67 8921801-7 1996 The adrenomedullin-induced nitrite production by interleukin-1 beta-stimulated cells was accompanied by increased inducible NO synthase mRNA and protein expression. Nitrites 27-34 nitric oxide synthase 2 Homo sapiens 114-135 8921801-8 1996 In the presence of dibutyryl cAMP, the interleukin-1 beta-induced nitrite accumulation was increased further, but the stimulatory effect of adrenomedullin on nitrite production was abolished. Nitrites 66-73 interleukin 1 beta Homo sapiens 39-57 8921801-8 1996 In the presence of dibutyryl cAMP, the interleukin-1 beta-induced nitrite accumulation was increased further, but the stimulatory effect of adrenomedullin on nitrite production was abolished. Nitrites 158-165 adrenomedullin Homo sapiens 140-154 8942505-5 1996 RESULTS: Cellular fibronectin was higher in maternal plasma of preeclamptic than nonpregnant women (6.1 +/- 0.29 vs 4.2 +/- 0.27 microgram/ml, p < 0.01), as were stimulated endothelial nitric oxide and prostacyclin production (nitric oxide 42.5 +/- 3.9 vs 26.9 +/- 2.3 nmol nitrite/microgram protein/24 hours, p < 0.05; prostacyclin 261.7 +/- 31.2 vs 151.9 +/- 18.7 pg prostaglandin F1 alpha/microgram protein/24 hours, p < 0.05). Nitrites 277-284 fibronectin 1 Homo sapiens 18-29 8895350-2 1996 NIC delays the formation of nitrite by interleukin (IL)-1 beta-(IL-1, 25 U/ml)-stimulated RINm5F cells, and previous exposure of cells to IL-1 for 15 h prevents this effect. Nitrites 28-35 interleukin 1 beta Rattus norvegicus 39-68 8937711-11 1996 Mouse RAW 264.7 macrophages produced high levels of nitrite when cultured overnight in the presence of lipopolysaccharide (LPS) and interferon-gamma. Nitrites 52-59 toll-like receptor 4 Mus musculus 123-126 8937711-11 1996 Mouse RAW 264.7 macrophages produced high levels of nitrite when cultured overnight in the presence of lipopolysaccharide (LPS) and interferon-gamma. Nitrites 52-59 interferon gamma Mus musculus 132-148 8937711-12 1996 Addition of 2-amino-4-methylpyridine at the same time as the LPS and IFN-gamma, dose-dependently reduced the levels of nitrite (IC50 = 1.5 microM) without affecting the induction of NOS II protein. Nitrites 119-126 toll-like receptor 4 Mus musculus 61-64 8937711-12 1996 Addition of 2-amino-4-methylpyridine at the same time as the LPS and IFN-gamma, dose-dependently reduced the levels of nitrite (IC50 = 1.5 microM) without affecting the induction of NOS II protein. Nitrites 119-126 interferon gamma Homo sapiens 69-78 9237228-10 1996 In the presence of TNF alpha, nitrite accumulation was significantly reduced in normozoospermic samples. Nitrites 30-37 tumor necrosis factor Homo sapiens 19-28 8958048-3 1996 Interleukin-4 (IL-4) and interleukin-13 (IL-13) but not interleukin-10 (IL-10) inhibited both iNOS mRNA expression and nitrite release in A549 cells. Nitrites 119-126 interleukin 4 Homo sapiens 0-13 8958048-3 1996 Interleukin-4 (IL-4) and interleukin-13 (IL-13) but not interleukin-10 (IL-10) inhibited both iNOS mRNA expression and nitrite release in A549 cells. Nitrites 119-126 interleukin 4 Homo sapiens 15-19 8958048-3 1996 Interleukin-4 (IL-4) and interleukin-13 (IL-13) but not interleukin-10 (IL-10) inhibited both iNOS mRNA expression and nitrite release in A549 cells. Nitrites 119-126 interleukin 13 Homo sapiens 25-39 8958048-3 1996 Interleukin-4 (IL-4) and interleukin-13 (IL-13) but not interleukin-10 (IL-10) inhibited both iNOS mRNA expression and nitrite release in A549 cells. Nitrites 119-126 interleukin 13 Homo sapiens 41-46 8898115-2 1996 The decreased nitrite formation was due not to the inhibition of nitric oxide synthase activity but to suppression of NOS II mRNA and protein expression. Nitrites 14-21 nitric oxide synthase 2, inducible Mus musculus 118-124 8957237-2 1996 Incubation of the cultures with interleukin-1 beta (10 ng/ml) for 24 h caused a significant increase in the accumulation of nitrite, a stable metabolite of NO. Nitrites 124-131 interleukin 1 beta Rattus norvegicus 32-50 8957237-3 1996 Although cilostazol itself showed no effect on nitrite accumulation, it stimulated interleukin-1 beta-induced nitrite accumulation in a concentration-dependent manner (10(-8)-10(-5) M). Nitrites 110-117 interleukin 1 beta Rattus norvegicus 83-101 8957237-6 1996 In the presence of dibutyryl-cAMP, interleukin-1 beta-induced nitrite accumulation was further increased, but the stimulatory effect of cilostazol on nitrite accumulation was blunted. Nitrites 62-69 interleukin 1 beta Rattus norvegicus 35-53 8911924-4 1996 Lipopolysaccharide or interleukin-1 beta increased nitrite production and inducible NO synthase mRNA levels, and ethanol potentiated this effect. Nitrites 51-58 interleukin 1 beta Rattus norvegicus 22-40 8897830-3 1996 Removal of glucose from the media partially inhibited IL-1 beta-stimulated nitrite (NO2-) production [8.1 +/- 0.3 vs. 4.4 +/- 0.6 nmol. Nitrites 75-82 interleukin 1 beta Rattus norvegicus 54-63 8871657-7 1996 In contrast, IL-1 receptor antagonist exerted near complete inhibition of NOS II mRNA and nitrite induction. Nitrites 90-97 interleukin 1 receptor antagonist Homo sapiens 13-37 8857923-5 1996 IL-1 beta (0.03 U/L) stimulated nitrite production by BVSMCs. Nitrites 32-39 interleukin 1 beta Bos taurus 0-9 8870682-8 1996 Expression of the inducible NO synthase in response to lipopolysaccharide and interferon-gamma caused apoptosis in RAW 264.7 macrophages and neomycin-vector controls within 24 h. In contrast, p53 antisense RNA-expressing clones appeared highly resistant towards endogenous NO, although inducible NO synthase induction with concomitant nitrite production remained unchanged. Nitrites 335-342 tumor protein p53 Homo sapiens 192-195 8883421-0 1996 Plasma nitrate plus nitrite changes during continuous intravenous infusion interleukin 2. Nitrites 20-27 interleukin 2 Homo sapiens 75-88 8883421-12 1996 We conclude that determination of plasma nitrate + nitrite levels during CIVI IL-2 can usefully estimate, in a dose-dependent pattern, the degree of peripheral vascular relaxation and capillary leakage associated with cytokine action, clinically manifested as hypotension. Nitrites 51-58 interleukin 2 Homo sapiens 78-82 8904645-8 1996 The IL-1 beta (60 u ml-1 for 24 h)-stimulated accumulation of nitrite, which was taken as an index of NO production, was concentration-dependently increased by preferential inhibitors of cyclic AMP-dependent phosphodiesterases (rolipram and trequinsin). Nitrites 62-69 interleukin 1 beta Homo sapiens 4-13 8977376-9 1996 We have shown earlier that the cytotoxic activity of CF2 is known to be Ca2+ dependent and CF2-induced production of nitrite and the cytotoxicity is inhibited by NG-monomethyl-L-arginine. Nitrites 117-124 coagulation factor II Mus musculus 53-56 8943726-1 1996 Although primary macrophages and most murine macrophage cell lines such as RAW 264.7 cells respond to interferon-gamma (IFN-gamma) and/or lipopolysaccharide (LPS) by producing large amounts of nitrite, i.e. the oxidation product of nitric oxide (NO) produced by inducible NO synthase (iNOS), other cell lines like P388.D1 cells do not produce significant amounts. Nitrites 193-200 interferon gamma Mus musculus 102-118 8977376-9 1996 We have shown earlier that the cytotoxic activity of CF2 is known to be Ca2+ dependent and CF2-induced production of nitrite and the cytotoxicity is inhibited by NG-monomethyl-L-arginine. Nitrites 117-124 coagulation factor II Mus musculus 91-94 8943726-1 1996 Although primary macrophages and most murine macrophage cell lines such as RAW 264.7 cells respond to interferon-gamma (IFN-gamma) and/or lipopolysaccharide (LPS) by producing large amounts of nitrite, i.e. the oxidation product of nitric oxide (NO) produced by inducible NO synthase (iNOS), other cell lines like P388.D1 cells do not produce significant amounts. Nitrites 193-200 interferon gamma Mus musculus 120-129 8977376-10 1996 Thus, it is suggested that O2- and nitrite are necessary for cell killing by CF2 in a Ca(2+)-dependent manner and the killing may possibly be by generation of peroxynitrite. Nitrites 35-42 coagulation factor II Mus musculus 77-80 8912158-11 1996 After RY, nitrite/nitrate concentration increased to 22.7 +/- 30.1, 32.4 +/- 21.4 and 44.6 +/- 32.7 mol/l in RY1, RY2 and RY3, respectively; in RY45, serum nitrite/nitrate concentration was normal averaging 6.1 +/- 1.2 mol/l. Nitrites 10-17 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 Rattus norvegicus 109-112 8864129-0 1996 Elevated TNF-alpha and inducible nitric oxide production by alveolar macrophages after exposure to a nitrite inhalant. Nitrites 101-108 tumor necrosis factor Mus musculus 9-18 8864137-20 1996 Serum levels of tumor necrosis factor-alpha (TNF-alpha and nitrite/nitrate in IFN-gamma-treated mice were similar to those of controls. Nitrites 59-66 interferon gamma Mus musculus 78-87 8902940-5 1996 Selective inhibition of iNOS with mercaptoethylguanidine (MEG) reduced plasma nitrite/nitrate levels, but did not prevent the development of vascular hyporeactivity, and did not improve survival in this model of CLP. Nitrites 78-85 nitric oxide synthase 2 Rattus norvegicus 24-28 8884978-9 1996 On study admission and at 2-h intervals, plasma CGRP concentrations correlated directly with nitrite and nitrate values. Nitrites 93-100 calcitonin related polypeptide alpha Homo sapiens 48-52 8958563-2 1996 ET-1 inhibited the nitrite accumulation induced by a combination of interleukin-1 beta, tumor necrosis factor-alpha, and lipopolysaccharide in a concentration-dependent manner. Nitrites 19-26 endothelin 1 Rattus norvegicus 0-4 8958563-2 1996 ET-1 inhibited the nitrite accumulation induced by a combination of interleukin-1 beta, tumor necrosis factor-alpha, and lipopolysaccharide in a concentration-dependent manner. Nitrites 19-26 interleukin 1 beta Rattus norvegicus 68-115 8958563-5 1996 These observations indicate that ET-1 inhibits cytokine-stimulated nitrite accumulation through the ETA receptor. Nitrites 67-74 endothelin 1 Rattus norvegicus 33-37 8958563-5 1996 These observations indicate that ET-1 inhibits cytokine-stimulated nitrite accumulation through the ETA receptor. Nitrites 67-74 endothelin receptor type A Rattus norvegicus 100-103 8958563-6 1996 Western blot analysis showed that the suppression of nitrite accumulation was accompanied by a decrease in iNOS protein. Nitrites 53-60 nitric oxide synthase 2 Rattus norvegicus 107-111 8884240-4 1996 Furthermore, interleukin-1 beta induced a dose-dependent increase in nitric oxide (NO) release and in intracellular cyclic GMP accumulation: nitrite release was similar in both smooth muscle cell models but cyclic GMP accumulation was greater in diabetic cells than in controls. Nitrites 141-148 interleukin 1 beta Rattus norvegicus 13-31 8880700-3 1996 SOD activity in CSF was measured by the nitrite method modified by Oyanagui. Nitrites 40-47 superoxide dismutase 1 Homo sapiens 0-3 9064335-6 1996 Blood mononuclear cells from RA patients had increased NOS activity and increased NOS2 antigen content as compared to those from normal subjects, and responded to interferon-gamma with increased NOS expression and nitrite/nitrate production in vitro. Nitrites 214-221 interferon gamma Homo sapiens 163-179 8853356-0 1996 Nitrite oxidation of myoglobin in perfused myocardium: implications for energy coupling in respiration. Nitrites 0-7 myoglobin Rattus norvegicus 21-30 8853356-5 1996 With > 10 mM infused nitrite, myoglobin (Mb) oxidation becomes apparent. Nitrites 24-31 myoglobin Rattus norvegicus 33-42 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrites 46-53 tumor necrosis factor Homo sapiens 135-168 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrites 46-53 TNF receptor superfamily member 1A Homo sapiens 216-219 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrites 46-53 TNF receptor superfamily member 1B Homo sapiens 224-227 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrites 46-53 interferon gamma Homo sapiens 307-323 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrites 46-53 interleukin 10 Homo sapiens 327-341 8784069-4 1996 The cytokine combination of interleukin-1 beta (50 U/mL), tumor necrosis factor-alpha (10(3) U/mL), and interferon-gamma (10(3) U/mL) induced significant increases in MDA and nitrite and significant decreases in insulin and DNA in islets after 60-h incubation. Nitrites 175-182 interleukin 1 beta Homo sapiens 28-46 8784069-4 1996 The cytokine combination of interleukin-1 beta (50 U/mL), tumor necrosis factor-alpha (10(3) U/mL), and interferon-gamma (10(3) U/mL) induced significant increases in MDA and nitrite and significant decreases in insulin and DNA in islets after 60-h incubation. Nitrites 175-182 interferon gamma Homo sapiens 104-120 8941965-10 1996 Messenger RNA for iNOS was maximally expressed by 8 h and remained detectable for at least 48 h. Expression of iNOS mRNA induced by cytokines and LPS varied with strength of the stimulus as determined by nitrite production in culture supernatant. Nitrites 204-211 nitric oxide synthase 2 Bos taurus 18-22 8822811-4 1996 Incubation of cells from Janvier and Charles River rats with lipopolysaccharide and/or interferon-gamma increased nitrite production to a similar extent. Nitrites 114-121 interferon gamma Rattus norvegicus 87-103 8702745-8 1996 Similarly, expression of the inducible NO synthase in response to lipopolysaccharide and interferon-gamma also caused apoptosis in RAW macrophages and neo controls within 24 h. In contrast, Bcl-2 transfectants appeared highly resistant, although inducible NO synthase levels increased along with concomitant nitrite production similar to control cells. Nitrites 308-315 nitric oxide synthase 2, inducible Mus musculus 29-50 8702745-8 1996 Similarly, expression of the inducible NO synthase in response to lipopolysaccharide and interferon-gamma also caused apoptosis in RAW macrophages and neo controls within 24 h. In contrast, Bcl-2 transfectants appeared highly resistant, although inducible NO synthase levels increased along with concomitant nitrite production similar to control cells. Nitrites 308-315 interferon gamma Mus musculus 89-105 8702745-8 1996 Similarly, expression of the inducible NO synthase in response to lipopolysaccharide and interferon-gamma also caused apoptosis in RAW macrophages and neo controls within 24 h. In contrast, Bcl-2 transfectants appeared highly resistant, although inducible NO synthase levels increased along with concomitant nitrite production similar to control cells. Nitrites 308-315 B cell leukemia/lymphoma 2 Mus musculus 190-195 8941965-10 1996 Messenger RNA for iNOS was maximally expressed by 8 h and remained detectable for at least 48 h. Expression of iNOS mRNA induced by cytokines and LPS varied with strength of the stimulus as determined by nitrite production in culture supernatant. Nitrites 204-211 nitric oxide synthase 2 Bos taurus 111-115 8704216-4 1996 Constitutive NOS expression was detected by Western blotting of cell lysates and by the accumulation of nitrite in the culture media. Nitrites 104-111 nitric oxide synthase 3 Homo sapiens 0-16 8842423-5 1996 Treatment of mesangial cells with IL-1 beta or the membrane-permeable cyclic AMP analogue, N6, 0-2"-dibutyryladenosine 3",5"-phosphate (Bt2 cyclic AMP) for 24 h induces iNOS activity measured as nitrite levels in cell culture supernatants by 44 fold or 33 fold, respectively. Nitrites 195-202 interleukin 1 beta Rattus norvegicus 34-43 8864559-6 1996 During a 6 h incubation period neither LPS nor IFN gamma alone exerted a significant effect but when combined, caused a prominent increase in nitrite formation, iNOS mRNA and protein abundance. Nitrites 142-149 interferon gamma Mus musculus 47-56 8842423-6 1996 Incubation of mesangial cells with tetranactin inhibits IL-1 beta- and cyclic AMP-dependent production of nitrite in a dose-dependent fashion with IC50 values of 50 nM and 10 nM, respectively. Nitrites 106-113 interleukin 1 beta Rattus norvegicus 56-65 8842423-8 1996 Western-blot analyses of mesangial cell extracts reveal that the inhibition of nitrite synthesis by tetranactin is due to a suppression of iNOS protein levels. Nitrites 79-86 nitric oxide synthase 2 Rattus norvegicus 139-143 8760410-4 1996 Parental and Tat-expressing macrophages accumulated identical levels of nitrite following lipopolysaccharide (LPS) stimulation. Nitrites 72-79 tyrosine aminotransferase Homo sapiens 13-16 8754764-1 1996 Isolated rat islets or RINm5F insulinoma cells treated with interleukin-1 beta (IL-1 beta) for 18 h show reduced glucose-sensitive insulin release and increased nitrite formation as a result of nitric oxide synthase induction. Nitrites 161-168 interleukin 1 beta Rattus norvegicus 60-78 8754764-1 1996 Isolated rat islets or RINm5F insulinoma cells treated with interleukin-1 beta (IL-1 beta) for 18 h show reduced glucose-sensitive insulin release and increased nitrite formation as a result of nitric oxide synthase induction. Nitrites 161-168 interleukin 1 beta Rattus norvegicus 80-89 8754764-5 1996 Nitrite formation in islets and RINm5F cells in response to IL-1 beta was also significantly reduced during culture with EA or DHEA, although nitrite levels were still elevated above control values. Nitrites 0-7 interleukin 1 beta Rattus norvegicus 60-69 8754764-7 1996 Pyrrolidine dithiocarbamate also reduced IL-1 beta-induced nitrite formation. Nitrites 59-66 interleukin 1 beta Rattus norvegicus 41-50 8759861-3 1996 Insertional inactivation of nnrR prevents growth on nitrite, as well as the reduction of nitrite and NO, but has no effect on reduction of nitrate or photosynthetic growth. Nitrites 52-59 Crp/Fnr family transcriptional regulator Rhodobacter sphaeroides 2.4.1 28-32 8759861-3 1996 Insertional inactivation of nnrR prevents growth on nitrite, as well as the reduction of nitrite and NO, but has no effect on reduction of nitrate or photosynthetic growth. Nitrites 89-96 Crp/Fnr family transcriptional regulator Rhodobacter sphaeroides 2.4.1 28-32 8760410-5 1996 Interferon gamma (IFN-gamma) stimulation however, resulted in reduced levels of nitrite accumulation as a direct consequence of Tat expression. Nitrites 80-87 interferon gamma Homo sapiens 0-27 8760410-5 1996 Interferon gamma (IFN-gamma) stimulation however, resulted in reduced levels of nitrite accumulation as a direct consequence of Tat expression. Nitrites 80-87 Tat Human immunodeficiency virus 1 128-131 8760410-6 1996 Conditioned media from Tat-expressing cells reduced the level of nitrite accumulation in parental cells following IFN-gamma stimulation but not stimulation with LPS. Nitrites 65-72 Tat Human immunodeficiency virus 1 23-26 8760410-6 1996 Conditioned media from Tat-expressing cells reduced the level of nitrite accumulation in parental cells following IFN-gamma stimulation but not stimulation with LPS. Nitrites 65-72 interferon gamma Homo sapiens 114-123 8674325-8 1996 Children with increased plasma IL-6 concentrations (n = 6) had increased plasma nitrite/nitrate concentrations (p < 0.01 on each day), increased organ failure scores (p < .05 on days 1 and 3), and the highest plasma IL-10 concentrations (p < .05 on days 1 and 3, p = .054 on day 2) when compared with children with sepsis and undetectable IL-6 concentrations. Nitrites 80-87 interleukin 6 Homo sapiens 31-35 8841982-7 1996 The rapidity of the effect of endotoxin on Ca2+ channel activity suggested that constitutive NOS (cNOS) was involved, in accordance with our finding that endotoxin-induced transcriptional induction of NOS, as measured by nitrite production, required > 6 hr. Nitrites 221-228 nitric oxide synthase 3 Rattus norvegicus 80-96 8837043-1 1996 Based on the inhibition of nitrite formation by generating superoxide from xanthine/xanthine oxidase (X/XO) reaction system, metallothionein (MT) and other sulfhydryl containing amino acids have been selected to test their abilities to scavenge superoxide radicals. Nitrites 27-34 xanthine dehydrogenase Mus musculus 84-100 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrites 253-260 interleukin 1 beta Rattus norvegicus 66-84 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrites 253-260 tumor necrosis factor Rattus norvegicus 98-125 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrites 253-260 interferon gamma Rattus norvegicus 139-155 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrites 253-260 interferon gamma Rattus norvegicus 157-166 16535368-7 1996 Cytochrome c was reduced via a different pathway when nitrite-reducing cells were incubated with acetate than when they were incubated with butyrate. Nitrites 54-61 cytochrome c3 family protein Pseudomonas stutzeri 0-12 16535368-8 1996 Furthermore, addition of antimycin A to nitrite-reducing cells resulted in partial inhibition of electron transport to cytochrome c in acetate-supplemented cells but not in butyrate-supplemented cells. Nitrites 40-47 cytochrome c3 family protein Pseudomonas stutzeri 119-131 8964116-4 1996 Microvessels were incubated in the presence of agonists for nitric oxide production (acetylcholine and bradykinin), which caused dose-dependent increases in nitrite, a response that was blocked by NG-nitro-L-arginine methyl ester and receptor-specific antagonists (atropine and HOE 140, respectively). Nitrites 157-164 kininogen 1 Homo sapiens 103-113 8964116-6 1996 Incubation with norepinephrine or the alpha2-adrenergic agonist BHT 920 also caused dose-dependent increases in nitrite production, which were blocked by the B2-receptor antagonist HOE 140. Nitrites 112-119 bradykinin receptor B2 Homo sapiens 158-169 8674325-9 1996 Children with sepsis and detectable IL-6 concentrations, and children with undetectable IL-6 concentrations, both had increased nitrite/nitrate concentrations (p < .005 on days 1 through 3) and increased IL-10 concentrations (p < .05 on days 1 and 2) compared with controls. Nitrites 128-135 interleukin 6 Homo sapiens 88-92 8655981-5 1996 CSF levels of NO/nitrite correlated with those of TNF-alpha (r = .55; P = .001) and glucose (r = -.43; P = .02). Nitrites 17-24 tumor necrosis factor Homo sapiens 50-59 8841941-2 1996 Incubation of cultured neonatal rat cardiac myocytes with interleukin-1 beta (IL-1 beta) caused a significant increase in the production of nitrite, a stable metabolite of NO. Nitrites 140-147 interleukin 1 beta Rattus norvegicus 58-76 8841941-3 1996 Addition of phenylephrine significantly augmented nitrite production by IL-1 beta-stimulated but not by unstimulated myocytes in a dose-dependent manner. Nitrites 50-57 interleukin 1 beta Rattus norvegicus 72-81 8841941-2 1996 Incubation of cultured neonatal rat cardiac myocytes with interleukin-1 beta (IL-1 beta) caused a significant increase in the production of nitrite, a stable metabolite of NO. Nitrites 140-147 interleukin 1 beta Rattus norvegicus 78-87 8764316-4 1996 Nitrite production by BSC-1 cells exposed to H2O2 increased almost 10-fold compared with control. Nitrites 0-7 solute carrier family 12 member 1 Homo sapiens 22-27 8783331-10 1996 TNF alpha significantly stimulated islet nitrite production and cGMP accumulation, both effects being of a similar magnitude in cryopreserved and noncryopreserved islets. Nitrites 41-48 tumor necrosis factor Homo sapiens 0-9 8679546-7 1996 Nitrite treatment of intact cells produced almost complete conversion to methemoglobin, but no detectable lipid extraction. Nitrites 0-7 hemoglobin subunit gamma 2 Homo sapiens 73-86 24178685-8 1996 Ang II also inhibited the IL-1beta induced nitrite accumulation by SMCs. Nitrites 43-50 angiotensinogen Homo sapiens 0-6 24178685-8 1996 Ang II also inhibited the IL-1beta induced nitrite accumulation by SMCs. Nitrites 43-50 interleukin 1 beta Homo sapiens 26-34 8635652-1 1996 The aim of this study was to investigate whether strain-dependent differences in beta-cell sensitivity to interleukin (IL) 1 beta exist in vitro and in vivo and if so, whether these differences correlate to variations in IL-1 beta-induced islet inducible nitric oxide synthase (iNOS) mRNA expression and nitrite production in vitro and islet iNOS protein content in vivo. Nitrites 304-311 interleukin 1 beta Rattus norvegicus 221-230 8635652-9 1996 In conclusion, the relative resistance of BN rat islets to IL-1 beta-induced inhibition of beta-cell function in vitro was associated with lower islet iNOS mRNA expression and nitrite production in this strain. Nitrites 176-183 interleukin 1 beta Rattus norvegicus 59-68 8647201-3 1996 Incubation of macrophages with both LPS and TNF-alpha resulted in the expression of both IL-1 beta and inducible nitric oxide synthase (iNOS) mRNA transcripts and increased the release of IL-1 beta protein and nitrite production in culture supernatants. Nitrites 210-217 toll-like receptor 4 Mus musculus 36-39 8647201-3 1996 Incubation of macrophages with both LPS and TNF-alpha resulted in the expression of both IL-1 beta and inducible nitric oxide synthase (iNOS) mRNA transcripts and increased the release of IL-1 beta protein and nitrite production in culture supernatants. Nitrites 210-217 tumor necrosis factor Mus musculus 44-53 8809546-7 1996 In mouse peritoneal macrophages treated with IFN-gamma, both L-NMMA and anti-TNF-alpha antibody inhibited nitrite production and restored CT replication. Nitrites 106-113 interferon gamma Mus musculus 45-54 8809546-1 1996 IFN-gamma and/or LPS induced nitrite production and inhibition of Chlamydia trachomatis (CT) replication in the murine macrophage cell line, RAW264.7. Nitrites 29-36 interferon gamma Mus musculus 0-9 8809546-7 1996 In mouse peritoneal macrophages treated with IFN-gamma, both L-NMMA and anti-TNF-alpha antibody inhibited nitrite production and restored CT replication. Nitrites 106-113 tumor necrosis factor Mus musculus 77-86 8641730-2 1996 Incubation of cultures with interleukin-1beta (10 ng/mL) for 24 hours caused a significant increase in nitrite generation. Nitrites 103-110 interleukin 1 beta Rattus norvegicus 28-45 8675186-3 1996 The current study demonstrates that PAF induced nitrite formation, the end product of nitric oxide synthesis, by Kupffer cells in a dose- and time-dependent manner. Nitrites 48-55 PCNA clamp associated factor Rattus norvegicus 36-39 8675186-5 1996 PAF augmented lipopolysaccharide (LPS)-induced expression of inducible nitric oxide synthase messenger RNA (mRNA), protein, nitrite and cyclic guanosine monophosphate (cGMP) levels in Kupffer cells. Nitrites 124-131 PCNA clamp associated factor Rattus norvegicus 0-3 8641730-3 1996 The interleukin-1beta-induced nitrite production by vascular smooth muscle cells was significantly increased by adrenomedullin in a dose-dependent manner (10(-10) to 10(-6) mol/L). Nitrites 30-37 interleukin 1 beta Rattus norvegicus 4-21 8675186-6 1996 Treatment of Kupffer cells with actinomycin D or cycloheximide inhibited PAF- and LPS-stimulated nitrite and nitric oxide synthase protein formation confirming that de novo synthesis of the enzyme occurred. Nitrites 97-104 PCNA clamp associated factor Rattus norvegicus 73-76 8675186-7 1996 In Kupffer cells, the presence of an arginine analog, NG-methyl-L-arginine, attenuated nitrite formation induced by PAF and LPS alone or in combination. Nitrites 87-94 PCNA clamp associated factor Rattus norvegicus 116-119 8641730-3 1996 The interleukin-1beta-induced nitrite production by vascular smooth muscle cells was significantly increased by adrenomedullin in a dose-dependent manner (10(-10) to 10(-6) mol/L). Nitrites 30-37 adrenomedullin Rattus norvegicus 112-126 8641730-5 1996 The adrenomedullin-induced nitrite production by interleukin-1beta-stimulated cells was accompanied by increased inducible nitric oxide synthase mRNA accumulation. Nitrites 27-34 adrenomedullin Rattus norvegicus 4-18 8641730-5 1996 The adrenomedullin-induced nitrite production by interleukin-1beta-stimulated cells was accompanied by increased inducible nitric oxide synthase mRNA accumulation. Nitrites 27-34 interleukin 1 beta Rattus norvegicus 49-66 8641730-6 1996 In the presence of the phosphodiesterase inhibitor isobutylmethylxanthine, interleukin-1beta-induced nitrite accumulation was further increased, but the effect of adrenomedullin was not additive or synergistic. Nitrites 101-108 interleukin 1 beta Rattus norvegicus 75-92 8782901-3 1996 Incubation of rat microglial cells with A beta(1-40) caused a significant increase in nitrite, a stable metabolite of nitric oxide (NO), in culture media, while there was no detectable increase in nitrite in astrocyte-rich glial cells or cortical neurons after incubation with A beta(1-40). Nitrites 86-93 amyloid beta precursor protein Homo sapiens 40-46 8854644-8 1996 RESULTS: Nitrite production in supernatants of Meth A ascites cell cultures was 63 +/- 14 microM in IL-2 treated mice and 3.2 +/- 1.5 microM in untreated controls (p < 0.001). Nitrites 9-16 interleukin 2 Mus musculus 100-104 8854644-9 1996 MLA prevented the IL-2 therapy induced increase in nitrite production. Nitrites 51-58 interleukin 2 Mus musculus 18-22 8626679-4 1996 Interleukin-1 beta and tumor necrosis factor-alpha, alone or in combination, stimulated both the uptake of L-arginine and the accumulation of nitrite in the culture media in a dose-dependent manner. Nitrites 142-149 interleukin 1 beta Rattus norvegicus 0-50 8626679-6 1996 Ang II in the presence of cytokines up-regulated L-arginine transport while inhibiting nitrite accumulation. Nitrites 87-94 angiotensinogen Rattus norvegicus 0-6 8782901-4 1996 Nitrite production by microglial cells was also induced by A beta(1-42), but not A beta(25-35). Nitrites 0-7 amyloid beta precursor protein Homo sapiens 59-65 8782901-6 1996 Among the various cytokines investigated such as interleukin-1, interleukin-6, tumor necrosis factor-alpha and interferon-gamma (IFN-gamma), only IFN-gamma markedly enhanced A beta-dependent nitrite production. Nitrites 191-198 interleukin 6 Homo sapiens 64-106 8782901-6 1996 Among the various cytokines investigated such as interleukin-1, interleukin-6, tumor necrosis factor-alpha and interferon-gamma (IFN-gamma), only IFN-gamma markedly enhanced A beta-dependent nitrite production. Nitrites 191-198 interferon gamma Homo sapiens 129-138 8782901-6 1996 Among the various cytokines investigated such as interleukin-1, interleukin-6, tumor necrosis factor-alpha and interferon-gamma (IFN-gamma), only IFN-gamma markedly enhanced A beta-dependent nitrite production. Nitrites 191-198 interferon gamma Homo sapiens 146-155 8782901-6 1996 Among the various cytokines investigated such as interleukin-1, interleukin-6, tumor necrosis factor-alpha and interferon-gamma (IFN-gamma), only IFN-gamma markedly enhanced A beta-dependent nitrite production. Nitrites 191-198 amyloid beta precursor protein Homo sapiens 174-180 8620596-6 1996 iNOS mRNA was expressed in the allograft heart and native lung and was associated with increased serum nitrite/nitrate levels. Nitrites 103-110 nitric oxide synthase 2 Rattus norvegicus 0-4 8804922-3 1996 Following injection of endotoxin (bacterial lipopolysaccharide) in rats we detected increased inducible NO synthase mRNA levels in the left ventricular wall within 30 min which then peaked at 3 h. This was followed by an increase in myocardial inducible NO synthase enzyme activity and plasma levels of NO metabolites, nitrate and nitrite, which peaked at 6 and 12 h, respectively. Nitrites 331-338 nitric oxide synthase 2 Rattus norvegicus 94-115 8928839-2 1996 The infusion of myoglobin (375 mg/kg) resulted in a decrease in renal blood flow, an increase in renal vascular resistance, and a decrease in creatine clearance associated with a decrease in urinary excretory rate of nitrite/nitrate and guanosine 3",5"-cyclic monophosphate (cGMP). Nitrites 217-224 LOW QUALITY PROTEIN: myoglobin Oryctolagus cuniculus 16-25 8620596-7 1996 iNOS inhibition with aminoguanidine prevented or attenuated allograft heart and systemic vascular barrier dysfunction and reduced allograft serum nitrite/nitrate levels to isograft values. Nitrites 146-153 nitric oxide synthase 2 Rattus norvegicus 0-4 8737408-9 1996 Both recombinant human chromogranin A and bovine chromogranin A triggered an important accumulation of nitrite comparable to that induced by lipopolysaccharide, a well-known activator of microglia. Nitrites 103-110 chromogranin A Bos taurus 49-63 8621213-3 1996 Therefore, we designed these studies to test the hypothesis that Ang II exerts time-dependent effects on renal NO generation as assessed from renal excretion of nitrate and nitrite, percent increases in renal vascular resistance during inhibition of NO synthase with intravenous NG -nitro-L-arginine methyl ester (L-NAME), or decreases in renal vascular resistance during stimulation of endothelial NO synthase with intravenous acetylcholine. Nitrites 173-180 angiotensinogen Rattus norvegicus 65-71 8621213-6 1996 The renal excretion of nitrate and nitrite was increased during short-term Ang II infusions (from 205 +/- 22 to 331 +/- 58 pmol.min-1, P < .05) but was unchanged during prolonged Ang II infusion (control group, 197 +/- 33 versus Ang II, 245 +/- 42 pmol.min-1, P=NS). Nitrites 35-42 angiotensinogen Rattus norvegicus 75-81 8780024-5 1996 We also found that interferon-gamma potentiated the effect of lipopolysaccharide on nitrite accumulation as previously described by others and depressed the lipopolysaccharide-evoked production of prostaglandin E2, prostaglandin D2, and thromboxane. Nitrites 84-91 interferon gamma Rattus norvegicus 19-35 8737408-9 1996 Both recombinant human chromogranin A and bovine chromogranin A triggered an important accumulation of nitrite comparable to that induced by lipopolysaccharide, a well-known activator of microglia. Nitrites 103-110 chromogranin A Homo sapiens 23-37 8730734-4 1996 LPS-induced nitrite production was markedly attenuated by the nitroxybutylester derivatives of flurbiprofen (FNBE), aspirin, ketoprofen, naproxen, diclofenac and ketorolac, with each compound reducing accumulated nitrite levels by > 40% at the maximum concentrations (100 micrograms ml-1) used. Nitrites 12-19 toll-like receptor 4 Mus musculus 0-3 8730734-4 1996 LPS-induced nitrite production was markedly attenuated by the nitroxybutylester derivatives of flurbiprofen (FNBE), aspirin, ketoprofen, naproxen, diclofenac and ketorolac, with each compound reducing accumulated nitrite levels by > 40% at the maximum concentrations (100 micrograms ml-1) used. Nitrites 213-220 toll-like receptor 4 Mus musculus 0-3 8730734-9 1996 FNBE reduced LPS-induced nitrite production when added to cells up to 4 h after LPS. Nitrites 25-32 toll-like receptor 4 Mus musculus 13-16 8730734-6 1996 Further examination revealed that nitrite production was inhibited in a concentration-dependent (1-100 micrograms ml-1) manner by FNBE which at 100 micrograms ml-1 decreased LPS-stimulated levels by 63.3 +/- 8.6% (n = 7). Nitrites 34-41 toll-like receptor 4 Mus musculus 174-177 8688491-3 1996 TGF-beta 1"s effect on stimulated rat peritoneal macrophage (MO) production of prostacyclin and nitric oxide were assessed via measurement of their stable metabolites, 6-keto-PGF-1 alpha and nitrite, respectively. Nitrites 191-198 transforming growth factor, beta 1 Rattus norvegicus 0-10 8762862-2 1996 The present study was undertaken to investigate the production of nitrite (NO2-) by the spleen cells of mice in vitro and in vivo following inoculation of CF2. Nitrites 66-73 coagulation factor II Mus musculus 155-158 8688491-6 1996 In a similar study, TGF-beta 1 pretreatment led to a significant (p < 0.05) reduction of LPS stimulated MO nitrite production. Nitrites 110-117 transforming growth factor, beta 1 Rattus norvegicus 20-30 8627326-0 1996 Ex vivo measurement of brain tissue nitrite and nitrate accurately reflects nitric oxide synthase activity in vivo. Nitrites 36-43 nitric oxide synthase 2 Homo sapiens 76-97 8618000-7 1996 Substance P (10 nM to 1 muM) and calcitonin gene-related peptide (100 pM to 10 nM) significantly (p<0.05) increased nitrite formation, and this increase was blocked by the competitive nitric oxide synthase antagonist, NG-monomethyl-L-arginine. Nitrites 119-126 tachykinin precursor 1 Homo sapiens 0-11 8627326-1 1996 The ex vivo tissue concentration of nitrite and nitrate (NOx) was found to correlate closely with the activity of nitric oxide synthase (NOS; EC 1.14.13.39) in various brain regions. Nitrites 36-43 nitric oxide synthase 2 Homo sapiens 114-135 8707887-6 1996 inhibitors of NOS activity (aminoguanidine, L-NAME) or iNOS induction (dexamethasone, TGF beta) reduced LPS-stimulated nitrite production. Nitrites 119-126 nitric oxide synthase 2 Homo sapiens 55-59 8732506-2 1996 Incubation of cardiac myocytes for 24 h with interleukin-1 beta (IL-1 beta) caused a significant increase in the production of nitrite, a stable metabolite of nitric oxide. Nitrites 127-134 interleukin 1 beta Rattus norvegicus 45-63 8732506-2 1996 Incubation of cardiac myocytes for 24 h with interleukin-1 beta (IL-1 beta) caused a significant increase in the production of nitrite, a stable metabolite of nitric oxide. Nitrites 127-134 interleukin 1 beta Rattus norvegicus 65-74 8732506-3 1996 Dibutyl cAMP (db-cAMP) significantly augmented nitrite production by IL-1 beta-stimulated, but not by unstimulated cells, in a dose-dependent manner. Nitrites 47-54 interleukin 1 beta Rattus norvegicus 69-78 8732506-6 1996 cAMP-induced nitrite production by cytokine-stimulated cells was accompanied by increased iNOS mRNA accumulation. Nitrites 13-20 nitric oxide synthase 2 Rattus norvegicus 90-94 8732506-7 1996 The synergistic effect of cAMP on IL-1 beta-induced nitrite accumulation was mimicked by cAMP-generating agonists forskolin and isoproterenol. Nitrites 52-59 interleukin 1 beta Rattus norvegicus 34-43 8602881-2 1996 Treatment of smooth muscle cells with IL-Beta stimulated inducible nitric oxide synthase (iNOS) mRNA expression, which preceded the release of NO (as measured by the accumulation of nitrite in the culture media). Nitrites 182-189 nitric oxide synthase 2 Homo sapiens 90-94 8707887-6 1996 inhibitors of NOS activity (aminoguanidine, L-NAME) or iNOS induction (dexamethasone, TGF beta) reduced LPS-stimulated nitrite production. Nitrites 119-126 transforming growth factor beta 1 Homo sapiens 86-94 8707887-10 1996 Induction of iNOS mRNA by LPS, or by proinflammatory cytokines, occurred prior to the rise of medium nitrite in time course studies and was diminished by dexamethasone. Nitrites 101-108 nitric oxide synthase 2 Homo sapiens 13-17 8613229-3 1996 When myocytes were treated with interleukin-1beta (5 ng/mL), nitrite levels increased, and this effect was inhibited 80% by the specific iNOS inhibitor aminoguanidine. Nitrites 61-68 interleukin 1 beta Mus musculus 32-49 8882611-4 1996 LTA (10 microgram ml-1) caused within 24 h an enhanced accumulation of nitrite (an indicator of NO biosynthesis) in the supernatant of J774.2 macrophages which was prevented by the non-selective NOS inhibitor NG-monomethyl-L-arginine (L-NMMA; IC50: 35 microM) or by the iNOS-selective NOS inhibitor, aminoethyl-isothiourea (AE-ITU; IC50: 6 microM). Nitrites 71-78 nitric oxide synthase 2, inducible Mus musculus 270-274 8608643-2 1996 IFN-gamma-activated macrophages produced nitric oxide (NO) in a dose-dependent manner, as measured by increased nitrite concentration in the culture supernatant. Nitrites 112-119 interferon gamma Mus musculus 0-9 8613229-3 1996 When myocytes were treated with interleukin-1beta (5 ng/mL), nitrite levels increased, and this effect was inhibited 80% by the specific iNOS inhibitor aminoguanidine. Nitrites 61-68 nitric oxide synthase 2, inducible Mus musculus 137-141 8830053-5 1996 S-EIU suppressed the release of nitrite and lactate dehydrogenase from rat vascular smooth muscle cells treated with interleukin-1 beta and forskolin more potently than L-NMA or L-NNA. Nitrites 32-39 interleukin 1 beta Rattus norvegicus 117-135 8636445-7 1996 In protocol 1, IGF-I alone increased forearm nitrite release at 4 h (P < 0.03), which was reduced back to baseline by L-NMMA at 6 h (P < 0.05). Nitrites 45-52 insulin like growth factor 1 Homo sapiens 15-20 8815312-5 1996 The appearance of i-NOS mRNA after endotoxin treatment of BV-2 cells was confirmed by Northern blot analysis and in situ hybridization histochemistry, and functional enzyme activity was followed by release of nitric oxide (as nitrite) into the medium. Nitrites 226-233 nitric oxide synthase 2, inducible Mus musculus 18-23 8599841-2 1996 Schwann cells treated with IFN-gamma and TNF-alpha upregulated iNOS-specific mRNA within 12 hr and released nitrite in a time- and dose-dependent manner, reaching a plateau of secretion after 3 days. Nitrites 108-115 interferon gamma Homo sapiens 27-36 8676552-9 1996 These results indicate that the reduced nitrite production in the kidney of DOCA-salt hypertensive rats was increased more effectively by trichlormethiazide than by captopril, via increased immunoreactivity for B-NOS in the macula densa, and prevented renal damage. Nitrites 40-47 nitric oxide synthase 1 Rattus norvegicus 211-216 8726464-4 1996 RESULTS: DFGiNOS-infected sheep pulmonary artery endothelial cells (SPAEC) expressed significant iNOS mRNA and protein, releasing nitrite levels of 155.0 +/- 10.7 nmol/mg protein/24 h vs. 5.5 +/- 1.1 by control cells. Nitrites 130-137 nitric oxide synthase, inducible Ovis aries 12-16 8599841-2 1996 Schwann cells treated with IFN-gamma and TNF-alpha upregulated iNOS-specific mRNA within 12 hr and released nitrite in a time- and dose-dependent manner, reaching a plateau of secretion after 3 days. Nitrites 108-115 tumor necrosis factor Homo sapiens 41-50 8631029-6 1996 In tumor-derived endothelial cells, we demonstrated that neither cytokine alone was capable of inducing nitrite but that the combination of IL-1 alpha/IFN-gamma induced dose-dependent nitrite, with peak levels observed after 4 days incubation. Nitrites 184-191 interleukin 1 alpha Mus musculus 140-150 8631029-6 1996 In tumor-derived endothelial cells, we demonstrated that neither cytokine alone was capable of inducing nitrite but that the combination of IL-1 alpha/IFN-gamma induced dose-dependent nitrite, with peak levels observed after 4 days incubation. Nitrites 184-191 interferon gamma Mus musculus 151-160 8631029-7 1996 When tumor-derived, normal yolk sac, mouse brain, or mouse aortic endothelial cells were treated with IL-1 alpha (100 units/ml)/IFN-gamma (10 units/ml), tumor-derived endothelial cells produced significantly more nitrite when compared to the normal endothelial cells. Nitrites 213-220 interleukin 1 alpha Mus musculus 102-112 8631029-7 1996 When tumor-derived, normal yolk sac, mouse brain, or mouse aortic endothelial cells were treated with IL-1 alpha (100 units/ml)/IFN-gamma (10 units/ml), tumor-derived endothelial cells produced significantly more nitrite when compared to the normal endothelial cells. Nitrites 213-220 interferon gamma Mus musculus 128-137 8631029-8 1996 Nitrite production from IL-1 alpha/IFN-gamma was sensitive to the nitric oxide synthase inhibitors, NG-methyl-L-arginine or NG-nitro-L-arginine in a dose-dependent manner. Nitrites 0-7 interleukin 1 alpha Mus musculus 24-34 8631029-8 1996 Nitrite production from IL-1 alpha/IFN-gamma was sensitive to the nitric oxide synthase inhibitors, NG-methyl-L-arginine or NG-nitro-L-arginine in a dose-dependent manner. Nitrites 0-7 interferon gamma Mus musculus 35-44 8631029-9 1996 In addition, dexamethasone significantly inhibited nitrite production from IL-1 alpha/IFN-gamma-treated, tumor-derived endothelial cells. Nitrites 51-58 interleukin 1 alpha Mus musculus 75-85 8631029-9 1996 In addition, dexamethasone significantly inhibited nitrite production from IL-1 alpha/IFN-gamma-treated, tumor-derived endothelial cells. Nitrites 51-58 interferon gamma Mus musculus 86-95 8576219-4 1996 S100 beta treatment of astrocytes induced a time- and dose-dependent increase in accumulation of the NO metabolite, nitrite, in the conditioned medium. Nitrites 116-123 S100 calcium binding protein B Rattus norvegicus 0-9 8576219-5 1996 The S100 beta- stimulated nitrite production was blocked by cycloheximide and by the NOS inhibitor N-nitro-L-arginine methylester, but not by the inactive D-isomer of the inhibitor. Nitrites 26-33 S100 calcium binding protein B Rattus norvegicus 4-13 8904084-2 1996 Interleukin-1beta stimulated the production of nitrite and nitrate, stable metabolites of NO, in a dose- and time-dependent manner in vascular smooth muscle cells. Nitrites 47-54 interleukin 1 beta Rattus norvegicus 0-17 8904084-3 1996 Dipyridamole (1-100 mu M) enhanced interleukin-1beta-induced nitrite production in a dose- and time-dependent manner. Nitrites 61-68 interleukin 1 beta Rattus norvegicus 35-52 8904084-5 1996 Both 8-bromo-guanosine 3",5"-cyclic monophosphate (8-bromo-cGMP) and dibutyryl adenosine 3",5"-cyclic monophosphate (db-cAMP) enhanced the nitrite production in the presence of interleukin-1beta. Nitrites 139-146 interleukin 1 beta Rattus norvegicus 177-194 8904084-6 1996 Dipyridamole up-regulated the effect of both 8-bromo-cGMP and db-cAMP on the interleukin-1beta-induced nitrite production. Nitrites 103-110 interleukin 1 beta Rattus norvegicus 77-94 8575064-2 1996 Since the activity of NOS3 is known to be regulated in part by the intracellular Ca2+ activity ([Ca2+]i) in endothelial cells, we determined whether increasing myocyte [Ca2+]i by uniform electric field pacing was accompanied by an increase in NOS3 activity, detected as nitrite accumulation in the medium. Nitrites 270-277 nitric oxide synthase 3 Rattus norvegicus 22-26 8904084-9 1996 Furthermore, Rolipram and 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (Ro-20-1724), cAMP-specific phosphodiesterase type IV inhibitors, augmented the interleukin-1beta-induced nitrite production. Nitrites 179-186 interleukin 1 beta Rattus norvegicus 153-170 8549863-7 1996 Use of arginine-free medium, without or with NG-monomethyl-L-arginine, resulted in inhibition of nitrite formation by 5-1,000 U/ml IFN+TNF and partial restoration of the insulin secretory response to glucose. Nitrites 97-104 tumor necrosis factor Rattus norvegicus 131-138 8630528-8 1996 The phosphodiesterase inhibitor 3-isobutyl-1-methyl xanthine reduced interleukin-1 beta-induced nitrite production at 3.3 mmol/l D-glucose, an effect that could be reproduced by the cAMP analog dibutyryl cAMP. Nitrites 96-103 interleukin 1 beta Rattus norvegicus 69-87 8630528-4 1996 Further, we wished to investigate the effects of agents increasing the intracellular concentration of cAMP on interleukin-1 beta-induced nitrite production. Nitrites 137-144 interleukin 1 beta Rattus norvegicus 110-128 8630528-5 1996 We demonstrated that D-glucose potentiated interleukin-1 beta-induced nitrite production in rat islets without affecting the mRNA level of the inducible nitric oxide synthase. Nitrites 70-77 interleukin 1 beta Rattus norvegicus 43-61 8609118-8 1996 Fresh explants of bovine articular synovial tissue constitutively released nitrite that was inhibited by N omega-nitro-L-arginine methyl ester, but the release could not be enhanced by endotoxin, interleukin-1 beta, or tumor necrosis factor-alpha. Nitrites 75-82 interleukin 1 beta Bos taurus 196-246 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. Nitrites 239-246 interleukin 1 beta Rattus norvegicus 115-133 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. Nitrites 239-246 interleukin 1 beta Rattus norvegicus 115-133 8609118-4 1996 Explants of human and bovine cartilage and cultured chondrocytes released large amounts of nitrite, the stable end product of nitric oxide, when stimulated with endotoxin, interleukin-1 beta, or tumor necrosis factor-alpha. Nitrites 91-98 interleukin 1 beta Bos taurus 172-222 8609118-5 1996 The production of nitrite was time-dependent and endotoxin, interleukin-1 beta, and tumor necrosis factor-alpha dose-dependent and was inhibited by the nitric-oxide-synthase inhibitors N omega-nitro-L-arginine methyl ester and aminoguanidine. Nitrites 18-25 interleukin 1 beta Bos taurus 60-111 8603997-5 1996 Unlike murine macrophages, THP-1 cells produced little nitrite in response to interferon-gamma (IFN-gamma) and lipopolysaccharide, and a-MSH inhibited this production only slightly. Nitrites 55-62 interferon gamma Homo sapiens 78-94 8603997-5 1996 Unlike murine macrophages, THP-1 cells produced little nitrite in response to interferon-gamma (IFN-gamma) and lipopolysaccharide, and a-MSH inhibited this production only slightly. Nitrites 55-62 interferon gamma Homo sapiens 96-105 8552616-2 1996 We have reported that nanomolar concentrations of dexamethasone suppress IL-1 beta-induced iNOS protein expression and production of nitrite, the stable end product of NO formation, without affecting IL-1 beta-triggered increase in iNOS mRNA levels. Nitrites 133-140 interleukin 1 beta Rattus norvegicus 73-82 8598655-7 1996 LPS/IFN-stimulated EMT-6 cells produced 25 microM nitrite at 24 hr and reached a plateau of 55 microM nitrite at 48 hr. Nitrites 50-57 interferon gamma Mus musculus 4-7 8598655-7 1996 LPS/IFN-stimulated EMT-6 cells produced 25 microM nitrite at 24 hr and reached a plateau of 55 microM nitrite at 48 hr. Nitrites 50-57 IL2 inducible T cell kinase Mus musculus 19-22 8598655-7 1996 LPS/IFN-stimulated EMT-6 cells produced 25 microM nitrite at 24 hr and reached a plateau of 55 microM nitrite at 48 hr. Nitrites 102-109 interferon gamma Mus musculus 4-7 8598655-7 1996 LPS/IFN-stimulated EMT-6 cells produced 25 microM nitrite at 24 hr and reached a plateau of 55 microM nitrite at 48 hr. Nitrites 102-109 IL2 inducible T cell kinase Mus musculus 19-22 8598655-9 1996 Finally, L-arginine was necessary in the media for nitrite accumulation by LPS/IFN-stimulated cells, with maximal accumulation at 1 mM L-arginine. Nitrites 51-58 interferon gamma Mus musculus 79-82 8967289-9 1996 NRAMP is similar to the membranous bacterial system transporting nitrites. Nitrites 65-73 solute carrier family 11 member 1 Homo sapiens 0-5 8598489-9 1996 These results demonstrate that, unlike TNF, IL-1 does not cause neutrophil degranulation in man, despite its ability to cause neutrophilia and the rapid release of IL-6, IL-8, and nitrite/nitrate. Nitrites 180-187 interleukin 1 beta Homo sapiens 44-48 8548421-9 1996 Simultaneous treatment with IFN-gamma and TNF-alpha or IL-1 beta induced elaboration of nitrite, an end product of nitric oxide, in rat but not human SMCs. Nitrites 88-95 interferon gamma Rattus norvegicus 28-37 8548421-9 1996 Simultaneous treatment with IFN-gamma and TNF-alpha or IL-1 beta induced elaboration of nitrite, an end product of nitric oxide, in rat but not human SMCs. Nitrites 88-95 tumor necrosis factor Rattus norvegicus 42-51 8548421-9 1996 Simultaneous treatment with IFN-gamma and TNF-alpha or IL-1 beta induced elaboration of nitrite, an end product of nitric oxide, in rat but not human SMCs. Nitrites 88-95 interleukin 1 beta Rattus norvegicus 55-64 8603506-10 1996 A marked reduction in nitrite production, a measure of enzyme activity, from thoracic aortas in response to stimulation by either acetylcholine or bradykinin also occurred. Nitrites 22-29 kininogen 1 Canis lupus familiaris 147-157 8598489-0 1996 IL-1 beta does not cause neutrophil degranulation but does lead to IL-6, IL-8, and nitrite/nitrate release when used in patients with cancer. Nitrites 83-90 interleukin 1 beta Homo sapiens 0-9 18475707-2 1996 Macrophages pre-treated with IL-4 and then stimulated with IFN-gamma or LPS showed significant inhibition in their ability to produce NO as measured by nitrite production. Nitrites 152-159 interleukin 4 Mus musculus 29-33 8614265-6 1996 AE-SeU and AP-SeU potently inhibited nitrite formation by immunostimulated J774 macrophages (a model of iNOS activity) with EC50 values of 10 and 4 microM respectively. Nitrites 37-44 nitric oxide synthase 2 Rattus norvegicus 104-108 8699928-3 1996 TQA also prevented IL-1 beta-triggered initiation of Arg-induced relaxation and nitrite accumulation. Nitrites 80-87 interleukin 1 beta Rattus norvegicus 19-28 18475707-2 1996 Macrophages pre-treated with IL-4 and then stimulated with IFN-gamma or LPS showed significant inhibition in their ability to produce NO as measured by nitrite production. Nitrites 152-159 interferon gamma Mus musculus 59-68 18475707-3 1996 Simultaneous treatment of IL-4 pre-incubated cells with IFN-gamma and LPS together augmented nitrite accumulation. Nitrites 93-100 interleukin 4 Mus musculus 26-30 18475707-3 1996 Simultaneous treatment of IL-4 pre-incubated cells with IFN-gamma and LPS together augmented nitrite accumulation. Nitrites 93-100 interferon gamma Mus musculus 56-65 7499858-4 1995 When cultured cells of various origins are infected with this recombinant virus, there is inducible expression of iNOS in the presence of isopropylthio-beta-galactoside, as determined by Western blot and by detection of nitrite, a NO oxidation product. Nitrites 220-227 nitric oxide synthase 2 Homo sapiens 114-118 9123917-3 1996 The nitrite ingestion caused a decline level of cytochrome P-450 and inhibition of lipid peroxidation in rat liver. Nitrites 4-11 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 48-64 7499860-7 1995 Concurrent stimulation of rIFN-gamma with either viable or killed BCG resulted in a strong nitrite production by macrophages. Nitrites 91-98 interferon gamma Rattus norvegicus 26-36 7499860-8 1995 Neutralization of IFN-gamma and TNF-alpha caused a complete inhibition of nitrite production. Nitrites 74-81 interferon gamma Rattus norvegicus 18-27 8524846-5 1995 In the absence of added H4B, NO synthesis by the cells was minimal, whereas cells grown with supplemental H4B or the H4B precursor sepiapterin generated NO (74.1 and 63.3 nmol of nitrite per 10(6) cells per 24 h, respectively). Nitrites 179-186 H4 clustered histone 4 Homo sapiens 106-109 8594915-2 1995 Maximal nitrite (NO2(-)) production by cultured neonatal rat cardiac myocytes was achieved with 500 U/ml interleukin-1 beta (IL-1 beta) for 48 h (4.6 +/- 0.3 nmol/1.25 x 10(5) cells; n = 12). Nitrites 8-15 interleukin 1 beta Rattus norvegicus 105-123 8594915-2 1995 Maximal nitrite (NO2(-)) production by cultured neonatal rat cardiac myocytes was achieved with 500 U/ml interleukin-1 beta (IL-1 beta) for 48 h (4.6 +/- 0.3 nmol/1.25 x 10(5) cells; n = 12). Nitrites 8-15 interleukin 1 beta Rattus norvegicus 125-134 8524846-5 1995 In the absence of added H4B, NO synthesis by the cells was minimal, whereas cells grown with supplemental H4B or the H4B precursor sepiapterin generated NO (74.1 and 63.3 nmol of nitrite per 10(6) cells per 24 h, respectively). Nitrites 179-186 H4 clustered histone 4 Homo sapiens 106-109 8680718-11 1995 8 The addition of TNF-alpha produced a significant (P < 0.001) 3 fold increase of IL-1 alpha/IFN-gamma-induced nitrite generation. Nitrites 114-121 interferon gamma Homo sapiens 96-105 8680718-7 1995 The combination of IL-1 alpha/IFN-gamma produced a highly significant (P < 0.001) 4 fold increase in nitrite production at 48 h, compared to basal values, while no other pair of cytokines was effective. Nitrites 104-111 interleukin 1 alpha Homo sapiens 19-29 8680718-7 1995 The combination of IL-1 alpha/IFN-gamma produced a highly significant (P < 0.001) 4 fold increase in nitrite production at 48 h, compared to basal values, while no other pair of cytokines was effective. Nitrites 104-111 interferon gamma Homo sapiens 30-39 8680718-9 1995 6 Studies with IL-1 alpha/IFN-gamma combination demonstrated a time dependent expression of iNOS mRNA, first observed at 6 h, peaked at 24 h and was undetectable by 72 h. IL-1 alpha (0.3-10 ng ml-1) and IFN-gamma (10-300 u ml-1) in combination induced a concentration-dependent expression of iNOS mRNA at 24 h. 7 Pretreatment with cycloheximide before IL-1 alpha/IFN-gamma stimulation reduced nitrite levels to basal values. Nitrites 393-400 interleukin 1 alpha Homo sapiens 15-25 8680718-8 1995 5 Time course studies with IL-1 alpha/IFN-gamma combination revealed significant (P < 0.001) increases in nitrite at 24 h (153 +/- 7), 48 h (306 +/- 24), and 72 h (384 +/- 15) compared to basal values of 50 +/- 4, 75 +/- 8, and 103 +/- 8 nM per 10(6) cells respectively. Nitrites 109-116 interleukin 1 alpha Homo sapiens 27-37 8680718-8 1995 5 Time course studies with IL-1 alpha/IFN-gamma combination revealed significant (P < 0.001) increases in nitrite at 24 h (153 +/- 7), 48 h (306 +/- 24), and 72 h (384 +/- 15) compared to basal values of 50 +/- 4, 75 +/- 8, and 103 +/- 8 nM per 10(6) cells respectively. Nitrites 109-116 interferon gamma Homo sapiens 38-47 8680718-9 1995 6 Studies with IL-1 alpha/IFN-gamma combination demonstrated a time dependent expression of iNOS mRNA, first observed at 6 h, peaked at 24 h and was undetectable by 72 h. IL-1 alpha (0.3-10 ng ml-1) and IFN-gamma (10-300 u ml-1) in combination induced a concentration-dependent expression of iNOS mRNA at 24 h. 7 Pretreatment with cycloheximide before IL-1 alpha/IFN-gamma stimulation reduced nitrite levels to basal values. Nitrites 393-400 interferon gamma Homo sapiens 26-35 8680718-9 1995 6 Studies with IL-1 alpha/IFN-gamma combination demonstrated a time dependent expression of iNOS mRNA, first observed at 6 h, peaked at 24 h and was undetectable by 72 h. IL-1 alpha (0.3-10 ng ml-1) and IFN-gamma (10-300 u ml-1) in combination induced a concentration-dependent expression of iNOS mRNA at 24 h. 7 Pretreatment with cycloheximide before IL-1 alpha/IFN-gamma stimulation reduced nitrite levels to basal values. Nitrites 393-400 nitric oxide synthase 2 Homo sapiens 92-96 8680718-10 1995 These data suggest that the IL-1 alpha/IFN-gamma-induced nitrite production by HT-29 cells is dependent on de novo protein synthesis, probably the iNOS enzyme. Nitrites 57-64 interleukin 1 alpha Homo sapiens 28-38 8680718-10 1995 These data suggest that the IL-1 alpha/IFN-gamma-induced nitrite production by HT-29 cells is dependent on de novo protein synthesis, probably the iNOS enzyme. Nitrites 57-64 interferon gamma Homo sapiens 39-48 8680718-10 1995 These data suggest that the IL-1 alpha/IFN-gamma-induced nitrite production by HT-29 cells is dependent on de novo protein synthesis, probably the iNOS enzyme. Nitrites 57-64 nitric oxide synthase 2 Homo sapiens 147-151 8719795-17 1995 The induction of nitrite release by cultured macrophages activated with LTA (10 micrograms ml-1 for 24 h) was inhibited by 74 +/- 4% by WEB2086 (3 x 10(-4) M), but not by BN52021, indicating that only WEB2086 acts on intracellular PAF receptors. Nitrites 17-24 PCNA clamp associated factor Rattus norvegicus 231-234 8680718-11 1995 8 The addition of TNF-alpha produced a significant (P < 0.001) 3 fold increase of IL-1 alpha/IFN-gamma-induced nitrite generation. Nitrites 114-121 tumor necrosis factor Homo sapiens 18-27 8719803-9 1995 Furthermore, activation of cells with LPS and IFN-gamma had no effect on uptake of the neutral amino acid L-citrulline but selectively increased the Vmax for L-arginine transport 2.8 fold and nitrite levels from 24 +/- 7 to 188 +/- 14 pmol micrograms-1 protein 24 h-1. Nitrites 192-199 interferon gamma Rattus norvegicus 46-55 8680718-11 1995 8 The addition of TNF-alpha produced a significant (P < 0.001) 3 fold increase of IL-1 alpha/IFN-gamma-induced nitrite generation. Nitrites 114-121 interleukin 1 alpha Homo sapiens 85-95 8719803-13 1995 Cycloheximide (1 microM) abolished induction of L-arginine transport and nitrite accumulation in response to LPS and IFN-gamma. Nitrites 73-80 interferon gamma Rattus norvegicus 117-126 8680718-13 1995 These findings suggest that the up-regulation by TNF-alpha of IL-1 alpha/IFN-gamma-induced nitrite generation is at the post-transcriptional level. Nitrites 91-98 tumor necrosis factor Homo sapiens 49-58 8680718-13 1995 These findings suggest that the up-regulation by TNF-alpha of IL-1 alpha/IFN-gamma-induced nitrite generation is at the post-transcriptional level. Nitrites 91-98 interleukin 1 alpha Homo sapiens 62-72 8680718-13 1995 These findings suggest that the up-regulation by TNF-alpha of IL-1 alpha/IFN-gamma-induced nitrite generation is at the post-transcriptional level. Nitrites 91-98 interferon gamma Homo sapiens 73-82 7489995-4 1995 Pretreatment of mice with IL-1 resulted in elevated levels of nitrite/nitrate in serum and in enhanced nitric oxide synthase (NOS) activity in liver cells isolated from these animals. Nitrites 62-69 interleukin 1 complex Mus musculus 26-30 7588294-6 1995 Nitrite accumulation in culture medium was induced by IFN-gamma in a time- and dose-dependent manner and inhibited by cotreatment with inhibitors of NOS activity and by dexamethasone. Nitrites 0-7 interferon gamma Rattus norvegicus 54-63 7588294-7 1995 IL-1 beta, TNF-alpha, and bacterial lipopolysaccharide were found to have weak stimulatory effects on nitrite production on their own. Nitrites 102-109 interleukin 1 beta Rattus norvegicus 0-9 7588294-7 1995 IL-1 beta, TNF-alpha, and bacterial lipopolysaccharide were found to have weak stimulatory effects on nitrite production on their own. Nitrites 102-109 tumor necrosis factor Rattus norvegicus 11-20 7588294-8 1995 However, IL-1 beta and TNF-alpha showed strong synergy with IFN-gamma, but, surprisingly, lipopolysaccharide was found to exert potent inhibitory effects on IFN-gamma-induced nitrite synthesis. Nitrites 175-182 interferon gamma Rattus norvegicus 157-166 7500055-9 1995 Incubation of OA cartilage in serum-free medium resulted in spontaneous release, for up to 72 h, of substantial amounts of nitrite (up to approximately 80 microM/100 mg wet tissue), which could be inhibited by at least 80% with various inhibitors of iNOS, including inhibitors of protein synthesis and transcription factor NF-kappa B, but which (unlike murine macrophage iNOS) was not sensitive to hydrocortisone or TGF-beta. Nitrites 123-130 nitric oxide synthase 2, inducible Mus musculus 250-254 7500055-9 1995 Incubation of OA cartilage in serum-free medium resulted in spontaneous release, for up to 72 h, of substantial amounts of nitrite (up to approximately 80 microM/100 mg wet tissue), which could be inhibited by at least 80% with various inhibitors of iNOS, including inhibitors of protein synthesis and transcription factor NF-kappa B, but which (unlike murine macrophage iNOS) was not sensitive to hydrocortisone or TGF-beta. Nitrites 123-130 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 323-333 7500055-9 1995 Incubation of OA cartilage in serum-free medium resulted in spontaneous release, for up to 72 h, of substantial amounts of nitrite (up to approximately 80 microM/100 mg wet tissue), which could be inhibited by at least 80% with various inhibitors of iNOS, including inhibitors of protein synthesis and transcription factor NF-kappa B, but which (unlike murine macrophage iNOS) was not sensitive to hydrocortisone or TGF-beta. Nitrites 123-130 nitric oxide synthase 2, inducible Mus musculus 371-375 7500055-9 1995 Incubation of OA cartilage in serum-free medium resulted in spontaneous release, for up to 72 h, of substantial amounts of nitrite (up to approximately 80 microM/100 mg wet tissue), which could be inhibited by at least 80% with various inhibitors of iNOS, including inhibitors of protein synthesis and transcription factor NF-kappa B, but which (unlike murine macrophage iNOS) was not sensitive to hydrocortisone or TGF-beta. Nitrites 123-130 transforming growth factor, beta 1 Mus musculus 416-424 7500055-10 1995 Exposure of OA-affected cartilage to interleukin 1 beta, tumor necrosis factor-alpha, and lipopolysaccharide resulted in approximately 20-50% augmentation of nitrite accumulation, which was also sensitive to cycloheximide and pyrrolidine dithiocarbamate. Nitrites 158-165 interleukin 1 beta Homo sapiens 37-84 8675632-4 1995 This correlated with changes in cNOS activity as determined by nitrite measurements. Nitrites 63-70 nitric oxide synthase 3 Bos taurus 32-36 8597057-2 1995 Pretreatment of mice with interleukin-1 beta (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity. Nitrites 83-90 interleukin 1 beta Mus musculus 26-44 7499964-8 1995 The formation of nitrites by interferon-gamma-activated macrophages was inhibited by TauCl in a dose-dependent manner. Nitrites 17-25 interferon gamma Homo sapiens 29-45 8597057-2 1995 Pretreatment of mice with interleukin-1 beta (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity. Nitrites 83-90 interleukin 1 complex Mus musculus 46-50 7488131-3 1995 Addition of CsA dose dependently suppresses IL-1 beta-induced nitrite formation (IC50 = 0.9 microM). Nitrites 62-69 interleukin 1 beta Rattus norvegicus 44-53 8614565-2 1995 In fact, stimulation with Escherichia coli lipopolysaccharide (LPS) (1 microgram ml-1) or tumor necrosis factor alpha (TNF alpha) (500 U ml-1) enhances nitrite release in cell supernatants, as determined by the Griess reaction. Nitrites 152-159 tumor necrosis factor Homo sapiens 119-128 7488131-4 1995 Western- and Northern blot analyses of mesangial cell extracts reveal that the inhibition of IL-1 beta-induced nitrite formation by CsA is due to decreased iNOS protein and iNOS mRNA steady state levels. Nitrites 111-118 interleukin 1 beta Rattus norvegicus 93-102 7488131-4 1995 Western- and Northern blot analyses of mesangial cell extracts reveal that the inhibition of IL-1 beta-induced nitrite formation by CsA is due to decreased iNOS protein and iNOS mRNA steady state levels. Nitrites 111-118 nitric oxide synthase 2 Rattus norvegicus 156-160 7592903-7 1995 Furthermore, SNP is capable of inhibiting LPS/TNF alpha-inducible nitrite release, as determined by Griess reaction. Nitrites 66-73 tumor necrosis factor Homo sapiens 46-55 8546274-5 1995 The induction of iNOS activity was associated with an associated with an increased level of nitrite, an end metabolite of the l-arginine-NO pathway, in bronchoalveolar lavage fluid. Nitrites 92-99 nitric oxide synthase, inducible Cavia porcellus 17-21 7503239-2 1995 LPS + interferon-gamma (IF-gamma) promoted a time-dependent increase in nitrite (a NO metabolite) and iNOS mRNA and the appearance of NF-kappa B p50 and p65 in nuclear protein extracts. Nitrites 72-79 interferon gamma Oryctolagus cuniculus 6-22 7503239-2 1995 LPS + interferon-gamma (IF-gamma) promoted a time-dependent increase in nitrite (a NO metabolite) and iNOS mRNA and the appearance of NF-kappa B p50 and p65 in nuclear protein extracts. Nitrites 72-79 interferon gamma Oryctolagus cuniculus 24-32 7588208-4 1995 Inhibitors of NFkappaB, diethyldithiocarbamate, pyrrolidine dithiocarbamate, and N-acetyl cysteine prevent IL-1-induced iNOS expression at the level of messenger RNA, protein, and nitrite generation. Nitrites 180-187 nitric oxide synthase 2 Rattus norvegicus 120-124 7593352-2 1995 Bovine cerebral endothelial cells (BCEC) stained positively for NADPH-diaphorase/NO synthase activity and spontaneously produced nitrite, a stable NO oxidation product, which accumulated in the culture medium in a linear way for 48 h. Low concentrations of TNF-alpha (0.5-2 ng/ml) significantly enhanced nitrite production after a 24-h incubation. Nitrites 129-136 tumor necrosis factor Bos taurus 257-266 7593352-5 1995 TNF-alpha also significantly enhanced nitrite production in bovine cerebral smooth muscle cells (BCSMC). Nitrites 38-45 tumor necrosis factor Bos taurus 0-9 8590304-8 1995 Consistent with mammalian IFN-gamma, the nitrite-inducing activity was found to be heat labile, with over 90% of the activity lost within 5 minutes of heating. Nitrites 41-48 interferon gamma Homo sapiens 26-35 7561088-10 1995 Increased susceptibility of IFN-gamma R alpha o/o mice was associated with impaired nitric oxide (NO) production, as indicated by significantly lower plasma nitrite levels and by more transient expression of spleen inducible NO synthase mRNA. Nitrites 157-164 interferon gamma Mus musculus 28-37 8564256-15 1995 Pretreatment of mice with IL-4 (0.01-1 micrograms i.v., 20 min before LPS), but not with IL-10 (1 micrograms i.v., 20 min before LPS), caused a dose-dependent reduction in this LPS-stimulated formation of nitrite by peritoneal macrophages ex vivo. Nitrites 205-212 interleukin 4 Mus musculus 26-30 8564256-17 1995 Activation of murine macrophages with LPS (1 microgram ml-1 for 24 h) in vitro caused a significant increase in nitrite release in the supernatant of these cells. Nitrites 112-119 toll-like receptor 4 Mus musculus 38-41 7545171-3 1995 Native alpha 2M and the alpha 2M receptor-recognized derivative, alpha 2M-methylamine (alpha 2M-MA), increased nitrite generation by the RAW 264.7 murine macrophage cell line. Nitrites 111-118 alpha-2-macroglobulin Mus musculus 7-15 7545171-3 1995 Native alpha 2M and the alpha 2M receptor-recognized derivative, alpha 2M-methylamine (alpha 2M-MA), increased nitrite generation by the RAW 264.7 murine macrophage cell line. Nitrites 111-118 alpha-2-macroglobulin Mus musculus 24-32 7545171-3 1995 Native alpha 2M and the alpha 2M receptor-recognized derivative, alpha 2M-methylamine (alpha 2M-MA), increased nitrite generation by the RAW 264.7 murine macrophage cell line. Nitrites 111-118 alpha-2-macroglobulin Mus musculus 24-32 7545171-3 1995 Native alpha 2M and the alpha 2M receptor-recognized derivative, alpha 2M-methylamine (alpha 2M-MA), increased nitrite generation by the RAW 264.7 murine macrophage cell line. Nitrites 111-118 alpha-2-macroglobulin Mus musculus 24-32 7553604-6 1995 They inhibited lipopolysaccharide (LPS) and interferon-gamma (IFN gamma) induced nitrite production by mouse peritoneal cells by more than 50% at 2.5-10 microM. Nitrites 81-88 interferon gamma Mus musculus 44-60 7553604-6 1995 They inhibited lipopolysaccharide (LPS) and interferon-gamma (IFN gamma) induced nitrite production by mouse peritoneal cells by more than 50% at 2.5-10 microM. Nitrites 81-88 interferon gamma Mus musculus 62-71 8861713-6 1995 Interferon-gamma (1-100 IU/ml) and interleukin-1 alpha (1-10 IU/ml) alone were, however, able to stimulate the accumulation of nitrite in a concentration-dependent manner. Nitrites 127-134 interleukin 1 alpha Rattus norvegicus 35-54 8861714-4 1995 Phorbol 12-myristate 13-acetate (10(-9) - 3 x 10(-6) M) produced a concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but enhanced nitrite accumulation when added 12 hours following stimulation with LPS and IFN-gamma. Nitrites 105-112 interferon regulatory factor 6 Homo sapiens 163-166 8861714-1 1995 The combination of lipopolysaccharide (LPS; 100 ng/ml) and interferon-gamma (IFN-gamma; 10 IU/ml) synergistically stimulated induction of nitric oxide synthase activity in J774 macrophages, measured by nitrite accumulation during an overnight incubation. Nitrites 202-209 interferon regulatory factor 6 Homo sapiens 39-42 8861714-1 1995 The combination of lipopolysaccharide (LPS; 100 ng/ml) and interferon-gamma (IFN-gamma; 10 IU/ml) synergistically stimulated induction of nitric oxide synthase activity in J774 macrophages, measured by nitrite accumulation during an overnight incubation. Nitrites 202-209 interferon gamma Homo sapiens 59-75 8861714-1 1995 The combination of lipopolysaccharide (LPS; 100 ng/ml) and interferon-gamma (IFN-gamma; 10 IU/ml) synergistically stimulated induction of nitric oxide synthase activity in J774 macrophages, measured by nitrite accumulation during an overnight incubation. Nitrites 202-209 interferon gamma Homo sapiens 77-86 8527732-3 1995 There was a highly significant, linear relationship between the concentration of nitrite and ARG in the CSF suggesting that the production of NO is dependent on the availability of ARG. Nitrites 81-88 ABL proto-oncogene 2, non-receptor tyrosine kinase Homo sapiens 93-96 8556991-4 1995 However, LPS combined with either EGF or PDGF caused a significant increase in nitrite/nitrate concentration relative to LPS alone and growth factor alone. Nitrites 79-86 epidermal growth factor like 1 Rattus norvegicus 34-37 8556991-5 1995 The highest level level of nitrite/nitrate concentration was observed with the triple combination of LPS, EGF, and PDGF. Nitrites 27-34 epidermal growth factor like 1 Rattus norvegicus 106-109 7593555-8 1995 Production of nitrite by CM-exposed RAW 264.7 cells was blocked by inhibitors of NOS (L-N-methylarginine or aminoguanidine) or by antibodies to murine IFN-gamma or IL-1 beta. Nitrites 14-21 interferon gamma Mus musculus 151-160 7593555-8 1995 Production of nitrite by CM-exposed RAW 264.7 cells was blocked by inhibitors of NOS (L-N-methylarginine or aminoguanidine) or by antibodies to murine IFN-gamma or IL-1 beta. Nitrites 14-21 interleukin 1 beta Mus musculus 164-173 8527732-3 1995 There was a highly significant, linear relationship between the concentration of nitrite and ARG in the CSF suggesting that the production of NO is dependent on the availability of ARG. Nitrites 81-88 ABL proto-oncogene 2, non-receptor tyrosine kinase Homo sapiens 181-184 7544012-4 1995 alpha-MSH inhibited production of NO, as estimated from nitrite production and nitration of endogenous macrophage proteins. Nitrites 56-63 pro-opiomelanocortin-alpha Mus musculus 0-9 7544123-1 1995 Incubation with holo-transferrin, but not apo-transferrin, induced the nitrite accumulation in the culture medium of rat aortic smooth muscle cells concentration- and time-dependently, which occurred after a lag period of 6 hours. Nitrites 71-78 transferrin Rattus norvegicus 21-32 7544010-2 1995 We report that exposure of lipopolysaccharide-stimulated murine macrophages to therapeutic concentrations of aspirin (IC50 = 3 mM) and hydrocortisone (IC50 = 5 microM) inhibited the expression of iNOS and production of nitrite. Nitrites 219-226 nitric oxide synthase 2, inducible Mus musculus 196-200 7543752-2 1995 In the present study, we demonstrate that a combination (CL) of interleukin-1 alpha, interferon gamma, tumor necrosis factor alpha and lipopolysaccharide induces nitrite (NO2) production in cultured rat Sertoli cells. Nitrites 162-169 interleukin 1 alpha Rattus norvegicus 64-83 7643383-0 1995 Nitrate and nitrite regulation of the Fnr-dependent aeg-46.5 promoter of Escherichia coli K-12 is mediated by competition between homologous response regulators (NarL and NarP) for a common DNA-binding site. Nitrites 12-19 neuronal pentraxin 2 Homo sapiens 171-175 7643383-1 1995 The NarL and NarP proteins are homologous response regulators that function to regulate anaerobic respiratory gene expression in response to nitrate and nitrite in Escherichia coli. Nitrites 153-160 neuronal pentraxin 2 Homo sapiens 13-17 7643383-3 1995 aeg-46.5 operon expression is further induced by the NarP protein in response to nitrate or nitrite and this induction is antagonized by NarL. Nitrites 92-99 neuronal pentraxin 2 Homo sapiens 53-57 7643383-12 1995 Single and double nucleotide substitutions in the -44.5 region reduced or abolished nitrate and nitrite induction of aeg-46.5 operon expression in vivo and prevented the binding of MBP-NarP and MBP-NarL to the control region in vitro. Nitrites 96-103 myelin basic protein Homo sapiens 181-184 7643383-12 1995 Single and double nucleotide substitutions in the -44.5 region reduced or abolished nitrate and nitrite induction of aeg-46.5 operon expression in vivo and prevented the binding of MBP-NarP and MBP-NarL to the control region in vitro. Nitrites 96-103 neuronal pentraxin 2 Homo sapiens 185-189 7643383-12 1995 Single and double nucleotide substitutions in the -44.5 region reduced or abolished nitrate and nitrite induction of aeg-46.5 operon expression in vivo and prevented the binding of MBP-NarP and MBP-NarL to the control region in vitro. Nitrites 96-103 myelin basic protein Homo sapiens 194-197 7643383-13 1995 Presumably, the NarP and NarL proteins compete for the -44.5 binding site to regulate aeg-46.5 operon expression in response to nitrate and nitrite. Nitrites 140-147 neuronal pentraxin 2 Homo sapiens 16-20 7542498-7 1995 Peritoneal macrophages have significantly enhanced nitrite/nitrate production and NOS activity after treatment with LPS and/or IFN-gamma, whereas monocyte nitrite/nitrate production and NOS activity are not altered by the treatments. Nitrites 51-58 interferon gamma Homo sapiens 127-136 7582541-6 1995 NAS (0.01-5 mM) caused a concentration-dependent inhibition of the accumulation of nitrite in the conditioned medium of LPS/interferon-gamma (IFN gamma)-stimulated RAW 264.7 macrophages and interleukin-1 beta (IL-1 beta)-activated vascular smooth muscle cells (VSMC). Nitrites 83-90 interferon gamma Rattus norvegicus 120-140 7582541-6 1995 NAS (0.01-5 mM) caused a concentration-dependent inhibition of the accumulation of nitrite in the conditioned medium of LPS/interferon-gamma (IFN gamma)-stimulated RAW 264.7 macrophages and interleukin-1 beta (IL-1 beta)-activated vascular smooth muscle cells (VSMC). Nitrites 83-90 interferon gamma Rattus norvegicus 142-151 7585804-5 1995 RESULTS: Stimulation by LPS or in combination with interferon-gamma increased the accumulation of nitrite in the supernatant of J774 macrophages or cardiac myocytes. Nitrites 98-105 interferon gamma Rattus norvegicus 51-67 7501421-4 1995 Significantly higher levels of nitrite (NO2) were detected in supernatants from macrophage cultures treated with rIFN-gamma (10 u/ml or 100 u/ml) which induced microbistatic macrophage activity as well as from macrophage cultures treated with LPS + rIFN- when compared with levels of nitrite detected in supernatants of infected macrophages treated with medium only. Nitrites 31-38 interferon gamma Rattus norvegicus 113-123 7501421-4 1995 Significantly higher levels of nitrite (NO2) were detected in supernatants from macrophage cultures treated with rIFN-gamma (10 u/ml or 100 u/ml) which induced microbistatic macrophage activity as well as from macrophage cultures treated with LPS + rIFN- when compared with levels of nitrite detected in supernatants of infected macrophages treated with medium only. Nitrites 284-291 interferon gamma Rattus norvegicus 113-123 7619827-1 1995 In the presence of a suitable electron acceptor such as mammalian cytochrome c, hydroxylamine oxidoreductase (HAO) from the chemolithotrophic bacterium Nitrosomonas europaea catalyzes the oxidation of hydroxylamine or hydrazine to nitrite or dinitrogen, respectively. Nitrites 231-238 cytochrome c, somatic Homo sapiens 66-78 8570854-10 1995 Anti-TNF antibody (1:1000) caused a reduction in the release of H2O2 and nitrite. Nitrites 73-80 tumor necrosis factor-like Rattus norvegicus 5-8 7478251-3 1995 Also, bFGF dose-dependently inhibited nitrite levels in treated cell supernatants. Nitrites 38-45 fibroblast growth factor 2 Homo sapiens 6-10 8575535-3 1995 Incubation of the cultures with interleukin-1 beta (10 ng/ml) for 24 h caused a significant increase in nitrite generation. Nitrites 104-111 interleukin 1 beta Rattus norvegicus 32-50 8575535-4 1995 The interleukin-1 beta-induced nitrite production by vascular smooth muscle cells was significantly inhibited by aldosterone in a dose (10(-9) approximately 10(-6) M)-dependent manner. Nitrites 31-38 interleukin 1 beta Rattus norvegicus 4-22 7621816-7 1995 Based on its phenotype and expression pattern as well as its structural similarities to NRAMPs and a nitrate transporter in Aspergillus nidulans, we discuss a possible role for MVL in nitrite/nitrate transport and its implications. Nitrites 184-191 Malvolio Drosophila melanogaster 177-180 7622526-3 1995 The induction of M-CSF mRNA expression by either oxidized low density lipoprotein (ox-LDL) or tumor necrosis factor-alpha (TNF alpha) was attenuated by NO donors, S-nitrosoglutathione (GSNO), sodium nitroprusside (SNP), and 3-morpholinosydnonimine, but not by cGMP analogues, glutathione, or nitrite. Nitrites 292-299 colony stimulating factor 1 Homo sapiens 17-22 7622526-3 1995 The induction of M-CSF mRNA expression by either oxidized low density lipoprotein (ox-LDL) or tumor necrosis factor-alpha (TNF alpha) was attenuated by NO donors, S-nitrosoglutathione (GSNO), sodium nitroprusside (SNP), and 3-morpholinosydnonimine, but not by cGMP analogues, glutathione, or nitrite. Nitrites 292-299 tumor necrosis factor Homo sapiens 94-121 7622526-3 1995 The induction of M-CSF mRNA expression by either oxidized low density lipoprotein (ox-LDL) or tumor necrosis factor-alpha (TNF alpha) was attenuated by NO donors, S-nitrosoglutathione (GSNO), sodium nitroprusside (SNP), and 3-morpholinosydnonimine, but not by cGMP analogues, glutathione, or nitrite. Nitrites 292-299 tumor necrosis factor Homo sapiens 123-132 7543244-3 1995 Because we have shown that tyrosine kinase inhibitors attenuate IL-1 beta-induced cyclooxygenase expression and prostaglandin production, we investigated the effect of tyrosine kinase inhibitors on IL-1 beta-induced nitrite production and iNOS mRNA expression in rat mesangial cells. Nitrites 216-223 interleukin 1 beta Rattus norvegicus 198-207 7543244-4 1995 The tyrosine kinase inhibitors genistein and herbimycin A attenuated IL-1 beta-induced nitrite production in a dose-dependent manner. Nitrites 87-94 interleukin 1 beta Rattus norvegicus 69-78 7606802-2 1995 After 6 days of culture with IL-4, human monocytes released detectable amounts of nitrite and L-citrulline that were inhibited in the presence of nitro-L-arginine (1 mM). Nitrites 82-89 interleukin 4 Homo sapiens 29-33 7606802-3 1995 Incubation with an anti-CD23 mAb Fab fragment that suppressed the biological effect of CD23 led to a strong reduction (50 to 70%) of the IL-4-induced nitrite and L-citrulline production. Nitrites 150-157 Fc epsilon receptor II Homo sapiens 24-28 7606802-3 1995 Incubation with an anti-CD23 mAb Fab fragment that suppressed the biological effect of CD23 led to a strong reduction (50 to 70%) of the IL-4-induced nitrite and L-citrulline production. Nitrites 150-157 FA complementation group B Homo sapiens 33-36 7606802-3 1995 Incubation with an anti-CD23 mAb Fab fragment that suppressed the biological effect of CD23 led to a strong reduction (50 to 70%) of the IL-4-induced nitrite and L-citrulline production. Nitrites 150-157 Fc epsilon receptor II Homo sapiens 87-91 7606802-3 1995 Incubation with an anti-CD23 mAb Fab fragment that suppressed the biological effect of CD23 led to a strong reduction (50 to 70%) of the IL-4-induced nitrite and L-citrulline production. Nitrites 150-157 interleukin 4 Homo sapiens 137-141 7606802-4 1995 Ligation of membrane-associated CD23 or stimulation with recombinant soluble CD23 elicited monocytes to release nitrite and L-citrulline that was suppressed by nitro-L-arginine. Nitrites 112-119 Fc epsilon receptor II Homo sapiens 32-36 7606802-4 1995 Ligation of membrane-associated CD23 or stimulation with recombinant soluble CD23 elicited monocytes to release nitrite and L-citrulline that was suppressed by nitro-L-arginine. Nitrites 112-119 Fc epsilon receptor II Homo sapiens 77-81 7606802-5 1995 Preactivation of human monocytes with IFN-gamma led to subsequent increased IL-4- and CD23-driven nitrite and L-citrulline productions that were also suppressed in the presence of either nitro-L-arginine or the anti-CD23 mAb Fab fragment. Nitrites 98-105 interferon gamma Homo sapiens 38-47 7606802-5 1995 Preactivation of human monocytes with IFN-gamma led to subsequent increased IL-4- and CD23-driven nitrite and L-citrulline productions that were also suppressed in the presence of either nitro-L-arginine or the anti-CD23 mAb Fab fragment. Nitrites 98-105 interleukin 4 Homo sapiens 76-80 7606802-5 1995 Preactivation of human monocytes with IFN-gamma led to subsequent increased IL-4- and CD23-driven nitrite and L-citrulline productions that were also suppressed in the presence of either nitro-L-arginine or the anti-CD23 mAb Fab fragment. Nitrites 98-105 Fc epsilon receptor II Homo sapiens 86-90 7606802-5 1995 Preactivation of human monocytes with IFN-gamma led to subsequent increased IL-4- and CD23-driven nitrite and L-citrulline productions that were also suppressed in the presence of either nitro-L-arginine or the anti-CD23 mAb Fab fragment. Nitrites 98-105 Fc epsilon receptor II Homo sapiens 216-220 7606802-5 1995 Preactivation of human monocytes with IFN-gamma led to subsequent increased IL-4- and CD23-driven nitrite and L-citrulline productions that were also suppressed in the presence of either nitro-L-arginine or the anti-CD23 mAb Fab fragment. Nitrites 98-105 FA complementation group B Homo sapiens 225-228 7540573-4 1995 Addition of IL-1 beta alone or in combination with tumor necrosis factor-alpha induced a concentration- and time-dependent expression of the iNOS gene and associated NO production (measured as nitrite) from both islets and RIN cells. Nitrites 193-200 tumor necrosis factor Rattus norvegicus 51-78 7540573-4 1995 Addition of IL-1 beta alone or in combination with tumor necrosis factor-alpha induced a concentration- and time-dependent expression of the iNOS gene and associated NO production (measured as nitrite) from both islets and RIN cells. Nitrites 193-200 nitric oxide synthase 2 Rattus norvegicus 141-145 7540573-4 1995 Addition of IL-1 beta alone or in combination with tumor necrosis factor-alpha induced a concentration- and time-dependent expression of the iNOS gene and associated NO production (measured as nitrite) from both islets and RIN cells. Nitrites 193-200 interleukin 1 beta Rattus norvegicus 12-21 7541323-9 1995 Concentrations of nitric oxide oxidation products, nitrite and nitrate, in incubation media were increased after exposure of cells to interferon-gamma. Nitrites 51-58 interferon gamma Homo sapiens 134-150 7541386-5 1995 Hepatocytes isolated from endotoxemic rats released increased amounts of nitric oxide, measured by nitrite production, in response to interferon gamma (gamma-IFN) alone or in combination with LPS, tumor necrosis factor alpha, macrophage-colony stimulating factor, granulocyte/macrophage-colony stimulating factor, or hepatocyte growth factor. Nitrites 99-106 interferon gamma Rattus norvegicus 134-161 7556978-4 1995 Nitrite levels in the culture medium were 4.2 +/- 1.4 and 24.0 +/- 5 pmol.islet-1.24 h-1 in control islets and in IL-1 beta-exposed islets, respectively (n = 6, p = 0.05). Nitrites 0-7 interleukin 1 beta Rattus norvegicus 114-123 7556978-5 1995 In islets exposed to IL-1 beta and cholera or pertussis toxins, nitrite levels were 9.1 +/- 3 and 12.4 +/- 6 pmol.islet-1.24 h-1, respectively (n = 6, NS vs control islets). Nitrites 64-71 interleukin 1 beta Rattus norvegicus 21-30 7541386-7 1995 Increased nitrite production by hepatocytes was due to increased expression of iNOS mRNA and protein and was correlated with the time following induction of acute endotoxemia. Nitrites 10-17 nitric oxide synthase 2 Rattus norvegicus 79-83 7607720-3 1995 Nitrite release increased from 27 +/- 2 up to 103 +/- 5, 145 +/- 17, 84 +/- 4, 107 +/- 16, and 54 +/- 4 pmol/mg (P < .05) in response to 10(-5) mol/L of Ang I, II, III, IV, and Ang-(1-7), respectively. Nitrites 0-7 ANG Canis lupus familiaris 156-159 7621072-5 1995 The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). Nitrites 204-211 integrin subunit alpha M Homo sapiens 82-87 7607720-3 1995 Nitrite release increased from 27 +/- 2 up to 103 +/- 5, 145 +/- 17, 84 +/- 4, 107 +/- 16, and 54 +/- 4 pmol/mg (P < .05) in response to 10(-5) mol/L of Ang I, II, III, IV, and Ang-(1-7), respectively. Nitrites 0-7 ANG Canis lupus familiaris 180-183 7621072-5 1995 The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). Nitrites 204-211 integrin subunit alpha X Homo sapiens 92-97 7607720-7 1995 Angiotensin type 1 and type 2 and receptors mediate nitrite release after Ang I, II, III, and Ang-(1-7), whereas only type 2 receptors mediate nitrite release after Ang IV. Nitrites 52-59 ANG Canis lupus familiaris 0-3 7621072-5 1995 The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). Nitrites 204-211 Fc epsilon receptor II Homo sapiens 135-139 7621072-5 1995 The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). Nitrites 204-211 integrin subunit alpha M Homo sapiens 148-153 7607720-7 1995 Angiotensin type 1 and type 2 and receptors mediate nitrite release after Ang I, II, III, and Ang-(1-7), whereas only type 2 receptors mediate nitrite release after Ang IV. Nitrites 52-59 ANG Canis lupus familiaris 74-77 7621072-5 1995 The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). Nitrites 204-211 integrin subunit alpha X Homo sapiens 163-168 7621072-5 1995 The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). Nitrites 204-211 interleukin 1 beta Homo sapiens 263-272 7621072-5 1995 The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). Nitrites 204-211 interleukin 6 Homo sapiens 274-278 7621072-5 1995 The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). Nitrites 204-211 tumor necrosis factor Homo sapiens 284-293 7607720-7 1995 Angiotensin type 1 and type 2 and receptors mediate nitrite release after Ang I, II, III, and Ang-(1-7), whereas only type 2 receptors mediate nitrite release after Ang IV. Nitrites 52-59 ANG Canis lupus familiaris 74-77 7541062-2 1995 In vitro, an inhibitor of NO synthase (NOS) reduced the candidacidal activity and nitrite-producing capacity of activated resident peritoneal macrophages from immunocompetent C.B-17 and immunodeficient SCID mice. Nitrites 82-89 nitric oxide synthase 1, neuronal Mus musculus 26-37 7590863-4 1995 In sera of patients, nitrite plus nitrate levels correlated significantly with neopterin, soluble tumor necrosis factor receptor 55 and 75, and beta 2-microglobulin. Nitrites 21-28 beta-2-microglobulin Homo sapiens 144-164 7615812-8 1995 The ET-1 effect does not involve nitric oxide since NG-monomethyl-L-arginine did not alter ET-1-induced RMIC contraction; in addition, ET-1 had only a minor effect on cGMP levels and no effect on nitrite production. Nitrites 196-203 endothelin 1 Rattus norvegicus 4-8 7539260-2 1995 PDTC decreased by 90% both IL-1 beta-induced increase in medium nitrite accumulation (an indicator of NO production) and induction of iNOS mRNA expression. Nitrites 64-71 interleukin 1 beta Homo sapiens 27-36 7538755-2 1995 Incubation of vascular smooth muscle cells with IL-1 beta resulted in the release of nitrite and in the intracellular accumulation of L-citrulline. Nitrites 85-92 interleukin 1 beta Rattus norvegicus 48-57 7538755-4 1995 Ethanol (6.5-650 mM) potentiated the IL-1 beta-mediated stimulation of iNOS mRNA production, the appearance of iNOS protein and the generation of nitrite and L-citrulline from smooth muscle cells in a concentration-dependent manner. Nitrites 146-153 interleukin 1 beta Rattus norvegicus 37-46 7536666-3 1995 In the current set of experiments, measuring nitrite, a stable water-soluble secreted metabolite of NO as an index of iNOS activity and 1,25-(OH)2D3 in lipid extracts of cells incubated with 200 nM 25-OHD3 as an index of 1-hydroxylase activity, we demonstrate that NO and 1,25-(OH)2D production by HD-11 cells are temporally related, induced by the same kinds of activating agents, and coordinately regulated. Nitrites 45-52 nitric oxide synthase 2 Gallus gallus 118-122 7536663-2 1995 Although none of the peptides when applied alone induced the production of nitrite, a stable end product of NO, each peptide dramatically enhanced nitrite production induced by a cytokine combination of interleukin-1 alpha and tumor necrosis factor-alpha. Nitrites 147-154 interleukin 1 alpha Rattus norvegicus 203-254 7536663-4 1995 Time-dependent nitrite production by the cytokines was increased by CNP cotreatment and inhibited by NG-methyl-L-arginine, indicating involvement of the L-arginine-NO pathway. Nitrites 15-22 natriuretic peptide C Rattus norvegicus 68-71 7536663-5 1995 Northern blot analysis showed that the augmented nitrite production was accompanied by an increase in iNOS messenger RNA. Nitrites 49-56 nitric oxide synthase 2 Rattus norvegicus 102-106 7769383-7 1995 The low-spin component of the spectrum has been assigned to an LPO-NO2- adduct due to the presence of some nitrite impurities originating either from commercial unpasteurized milk or from external sources. Nitrites 107-114 lactoperoxidase Homo sapiens 63-66 7536776-6 1995 iNOS mRNA was expressed maximally 6 h after stimulation with S. dublin, whereas maximal nitrite accumulation in supernatants was measured at 24 to 48 h. Significant differences with regard to cytokine regulation of iNOS were observed between murine and bovine macrophages cultured under identical conditions. Nitrites 88-95 nitric oxide synthase 2, inducible Mus musculus 215-219 7536934-8 1995 Pretreatment of J774.2 cells with anti-LC1 (1:60 dilution at 4 h prior to LPS) also abolished the inhibitory effect of dexamethasone on iNOS expression and nitrite accumulation but not that on COX-2 expression. Nitrites 156-163 microtubule-associated protein 1B Mus musculus 39-42 7537701-3 1995 Here we demonstrate that injection of endotoxin into rats leads to the expression of an inducible isoform of .NO synthase (iNOS) in the thoracic aorta at 6 h and an increase in the circulating levels of nitrite/nitrate. Nitrites 203-210 nitric oxide synthase 2 Rattus norvegicus 123-127 7537467-2 1995 Under basal conditions, the production of nitrite, a stable metabolite of NO, was negligible; however, incubation with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IF-gamma) for 24 h resulted in a 12-fold increase in nitrite synthesis and the appearance of abundant iNOS mRNA and protein. Nitrites 42-49 tumor necrosis factor Mus musculus 119-146 7537467-2 1995 Under basal conditions, the production of nitrite, a stable metabolite of NO, was negligible; however, incubation with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IF-gamma) for 24 h resulted in a 12-fold increase in nitrite synthesis and the appearance of abundant iNOS mRNA and protein. Nitrites 42-49 interferon gamma Mus musculus 163-179 7537467-2 1995 Under basal conditions, the production of nitrite, a stable metabolite of NO, was negligible; however, incubation with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IF-gamma) for 24 h resulted in a 12-fold increase in nitrite synthesis and the appearance of abundant iNOS mRNA and protein. Nitrites 42-49 interferon gamma Mus musculus 181-189 7537467-2 1995 Under basal conditions, the production of nitrite, a stable metabolite of NO, was negligible; however, incubation with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IF-gamma) for 24 h resulted in a 12-fold increase in nitrite synthesis and the appearance of abundant iNOS mRNA and protein. Nitrites 234-241 tumor necrosis factor Mus musculus 119-146 7537467-2 1995 Under basal conditions, the production of nitrite, a stable metabolite of NO, was negligible; however, incubation with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IF-gamma) for 24 h resulted in a 12-fold increase in nitrite synthesis and the appearance of abundant iNOS mRNA and protein. Nitrites 234-241 tumor necrosis factor Mus musculus 148-157 7537467-2 1995 Under basal conditions, the production of nitrite, a stable metabolite of NO, was negligible; however, incubation with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IF-gamma) for 24 h resulted in a 12-fold increase in nitrite synthesis and the appearance of abundant iNOS mRNA and protein. Nitrites 234-241 interferon gamma Mus musculus 163-179 7537467-2 1995 Under basal conditions, the production of nitrite, a stable metabolite of NO, was negligible; however, incubation with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IF-gamma) for 24 h resulted in a 12-fold increase in nitrite synthesis and the appearance of abundant iNOS mRNA and protein. Nitrites 234-241 interferon gamma Mus musculus 181-189 7537467-3 1995 The induction of nitrite production and iNOS mRNA was time dependent, requiring approximately 8 h for expression of significant levels of nitrite or iNOS mRNA. Nitrites 17-24 nitric oxide synthase 2, inducible Mus musculus 149-153 7537467-3 1995 The induction of nitrite production and iNOS mRNA was time dependent, requiring approximately 8 h for expression of significant levels of nitrite or iNOS mRNA. Nitrites 138-145 nitric oxide synthase 2, inducible Mus musculus 40-44 7541741-8 1995 Bacterial lipopolysaccharide (LPS), a potent inducer of NOS, caused an increase in nitrite concentrations in pericyte supernatants 24 h after stimulation suggesting the presence of inducible NOS (iNOS). Nitrites 83-90 nitric oxide synthase 2 Homo sapiens 181-194 7541741-8 1995 Bacterial lipopolysaccharide (LPS), a potent inducer of NOS, caused an increase in nitrite concentrations in pericyte supernatants 24 h after stimulation suggesting the presence of inducible NOS (iNOS). Nitrites 83-90 nitric oxide synthase 2 Homo sapiens 196-200 7536714-6 1995 Induction of nitrite/nitrate production by the combination of tumor necrosis factor-alpha and bacterial lipopolysaccharide or that of interleukin-1 alpha and interferon gamma (100 U/mL) was also inhibited by cyclosporin A cotreatment. Nitrites 13-20 tumor necrosis factor Rattus norvegicus 62-89 7640349-8 1995 The medium nitrite accumulation, as an index of nitric oxide formation, was not influenced by IL-4 (10 ng/ml) alone, whilst IL-1 beta stimulation of medium nitrite was partly reduced by IL-4. Nitrites 156-163 interleukin 1 beta Rattus norvegicus 124-133 7640349-8 1995 The medium nitrite accumulation, as an index of nitric oxide formation, was not influenced by IL-4 (10 ng/ml) alone, whilst IL-1 beta stimulation of medium nitrite was partly reduced by IL-4. Nitrites 156-163 interleukin 4 Rattus norvegicus 186-190 7536714-2 1995 A combination of interleukin-1 alpha (100 U/mL) and tumor necrosis factor--alpha (5000 U/mL) induced accumulation of nitrite/nitrate, the stable end products of nitric oxide, in culture media within 48 hours. Nitrites 117-124 tumor necrosis factor Rattus norvegicus 17-80 7536714-6 1995 Induction of nitrite/nitrate production by the combination of tumor necrosis factor-alpha and bacterial lipopolysaccharide or that of interleukin-1 alpha and interferon gamma (100 U/mL) was also inhibited by cyclosporin A cotreatment. Nitrites 13-20 interleukin 1 alpha Rattus norvegicus 134-153 7536714-6 1995 Induction of nitrite/nitrate production by the combination of tumor necrosis factor-alpha and bacterial lipopolysaccharide or that of interleukin-1 alpha and interferon gamma (100 U/mL) was also inhibited by cyclosporin A cotreatment. Nitrites 13-20 interferon gamma Rattus norvegicus 158-185 7706480-7 1995 Measured by nitrite production, transfected HIT, and NIT-1 cells exhibited a more than 10-fold decrease in IL-1 beta sensitivity. Nitrites 12-19 interleukin 1 beta Mus musculus 107-116 7721443-4 1995 We determined serum levels of nitrite/nitrate (NO2 + NO3) at baseline and during the 6th, 12th, and 24th months of the study in two groups of PMW. Nitrites 30-37 NBL1, DAN family BMP antagonist Homo sapiens 53-56 7534984-1 1995 Consistent with stimulation of expression of an inducible form of nitric oxide synthase (iNOS), exposure of rat astroglial cultures to lipopolysaccharide (LPS) caused a time-dependent increase in the accumulation of nitrite in the culture media. Nitrites 216-223 nitric oxide synthase 2 Rattus norvegicus 89-93 7722422-4 1995 In the presence of IFN-gamma, immune complexes of IgG1, IgG2, IgG2b, or IgG3 isotype increased nitrite levels, whereas complexes of IgM isotype did not. Nitrites 95-102 interferon gamma Mus musculus 19-28 7722422-4 1995 In the presence of IFN-gamma, immune complexes of IgG1, IgG2, IgG2b, or IgG3 isotype increased nitrite levels, whereas complexes of IgM isotype did not. Nitrites 95-102 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 50-54 7722422-4 1995 In the presence of IFN-gamma, immune complexes of IgG1, IgG2, IgG2b, or IgG3 isotype increased nitrite levels, whereas complexes of IgM isotype did not. Nitrites 95-102 immunoglobulin heavy constant gamma 2B Mus musculus 62-67 7722422-4 1995 In the presence of IFN-gamma, immune complexes of IgG1, IgG2, IgG2b, or IgG3 isotype increased nitrite levels, whereas complexes of IgM isotype did not. Nitrites 95-102 Immunoglobulin heavy constant gamma 3 Mus musculus 72-76 7781710-5 1995 Sevoflurane impaired nitrite accumulation stimulated by bradykinin, and reduced the amount of NO released from endothelial cells. Nitrites 21-28 kininogen 1 Homo sapiens 56-66 7534984-2 1995 Addition of the peptide angiotensin II (ANG II) with LPS decreased subsequent formation of nitrite in a concentration-dependent manner (concentration inhibiting 50% of maximal response approximately 1 nM). Nitrites 91-98 angiotensinogen Rattus norvegicus 24-38 7534984-2 1995 Addition of the peptide angiotensin II (ANG II) with LPS decreased subsequent formation of nitrite in a concentration-dependent manner (concentration inhibiting 50% of maximal response approximately 1 nM). Nitrites 91-98 angiotensinogen Rattus norvegicus 40-46 7542532-8 1995 The inhibition by glibenclamide (3 microM) of the increase in nitrite induced by LPS in J774.2 macrophages was weaker when glibenclamide was given several hours after LPS, indicating that glibenclamide inhibits the induction, but not the activity, of iNOS. Nitrites 62-69 nitric oxide synthase 2 Rattus norvegicus 251-255 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitrites 209-216 interleukin 1 beta Rattus norvegicus 31-49 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitrites 209-216 interleukin 1 beta Rattus norvegicus 51-60 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitrites 209-216 tumor necrosis factor Rattus norvegicus 66-93 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitrites 209-216 tumor necrosis factor Rattus norvegicus 95-104 7535004-5 1995 Increasing the concentration of IL-1 beta and TNF-alpha caused a progressive elevation in nitrite production but did not further stimulate L-arginine uptake. Nitrites 90-97 interleukin 1 beta Rattus norvegicus 32-41 7535004-5 1995 Increasing the concentration of IL-1 beta and TNF-alpha caused a progressive elevation in nitrite production but did not further stimulate L-arginine uptake. Nitrites 90-97 tumor necrosis factor Rattus norvegicus 46-55 7535004-6 1995 Treatment of SMC with the combination of TNF-alpha and interferon-gamma (IFN-gamma) synergistically enhanced nitrite release without having any additional effect on L-arginine transport. Nitrites 109-116 tumor necrosis factor Rattus norvegicus 41-50 7535004-6 1995 Treatment of SMC with the combination of TNF-alpha and interferon-gamma (IFN-gamma) synergistically enhanced nitrite release without having any additional effect on L-arginine transport. Nitrites 109-116 interferon gamma Rattus norvegicus 55-71 7535004-6 1995 Treatment of SMC with the combination of TNF-alpha and interferon-gamma (IFN-gamma) synergistically enhanced nitrite release without having any additional effect on L-arginine transport. Nitrites 109-116 interferon gamma Rattus norvegicus 73-82 7535004-8 1995 Finally, treatment of SMC with interferon-gamma and N6,2"-O-dibutyryl adenosine 3",5"-cyclic monophosphate selectively stimulated the formation of nitrite by SMC but had no effect on L-arginine transport. Nitrites 147-154 interferon gamma Rattus norvegicus 31-47 7558509-3 1995 In the present study, dexamethasone was administered in vivo and was also used to treat macrophages in vitro prior to, and during, stimulation of nitrite production by interferon-gamma (IFN-gamma) and/or bacterial lipopolysaccharide (LPS). Nitrites 146-153 interferon gamma Mus musculus 168-184 7875768-4 1995 Treatment of cardiocytes with 3.4 nmol/L IL-1 beta for 24 hours stimulated NO (nitrite) production by threefold, which resulted from an increase in the inducible isoform of NO synthase mRNA. Nitrites 79-86 interleukin 1 beta Homo sapiens 41-50 7875768-5 1995 Dexamethasone inhibited IL-1 beta induction of nitrite production, whereas the protein kinase C inhibitor staurosporine had no effect. Nitrites 47-54 interleukin 1 beta Homo sapiens 24-33 7558509-5 1995 In most cases, these cells produced an equal or greater concentration of nitrite in response to IFN-gamma, LPS, or IFN-gamma plus LPS, than cells from vehicle control mice. Nitrites 73-80 interferon gamma Mus musculus 96-105 7533786-6 1995 iNOS mRNA levels were paralleled by changes in nitrite (a metabolic product of NO). Nitrites 47-54 nitric oxide synthase 2 Rattus norvegicus 0-4 7868243-6 1995 Addition of anti-IFN-gamma monoclonal antibodies to cultures of spleen cells from mice infected for 7 or 14 days remarkably decreased the levels of nitrite and resulted in a 47- and 4-fold increase in proliferation induced by stimulation with ConA or TLA, respectively. Nitrites 148-155 interferon gamma Mus musculus 17-26 7533786-9 1995 Transforming growth factor-beta 1 decreased IFN-gamma/TNF-alpha--stimulated iNOS mRNA and nitrite. Nitrites 90-97 transforming growth factor, beta 1 Rattus norvegicus 0-33 7533786-9 1995 Transforming growth factor-beta 1 decreased IFN-gamma/TNF-alpha--stimulated iNOS mRNA and nitrite. Nitrites 90-97 interferon gamma Rattus norvegicus 44-53 7533786-9 1995 Transforming growth factor-beta 1 decreased IFN-gamma/TNF-alpha--stimulated iNOS mRNA and nitrite. Nitrites 90-97 tumor necrosis factor Rattus norvegicus 54-63 7538104-8 1995 We detected inhibitory activity toward L1210 growth in serum of mice administered with hM-CSF, and the degree of the inhibitory activity was correlated with the level of nitrite (NO2-) in the serum. Nitrites 170-177 colony stimulating factor 1 Homo sapiens 87-93 7861129-4 1995 This inhibitor of ET-1 production was purified by gel-exclusion and ion-exchange chromatography as a 280-Da iron-containing molecule, able to release nitrites upon degradation. Nitrites 150-158 endothelin 1 Rattus norvegicus 18-22 7532189-9 1995 TGF-beta reduced expression of cardiac myocyte iNOS message and protein, reduced nitrite production, and reduced NO-mediated cytotoxicity in parallel. Nitrites 81-88 transforming growth factor, beta 1 Rattus norvegicus 0-8 8529105-6 1995 RESULTS: Expression of the transgene correlated with three Lshr-associated lipopolysaccharide/interferon-gamma-regulated macrophage activation phenotypes: respiratory burst, nitrite release, and uptake of L-arginine. Nitrites 174-181 interferon gamma Mus musculus 94-110 7774683-1 1995 Incubation of cultured rat vascular smooth muscle cells with interleukin-1 beta caused a significant increase in the production of nitrite, a stable metabolite of nitric oxide (NO), in time- and dose-dependent manners. Nitrites 131-138 interleukin 1 beta Rattus norvegicus 61-79 7774683-2 1995 Addition of ouabain to the culture further enhanced interleukin-1 beta-induced nitrite production. Nitrites 79-86 interleukin 1 beta Rattus norvegicus 52-70 7774683-4 1995 The calcium ionophore ionomycin also significantly enhanced interleukin-1 beta-induced nitrite generation. Nitrites 87-94 interleukin 1 beta Rattus norvegicus 60-78 7531975-4 1995 Protein kinase C activation led to enhanced mRNA expression of iNOS, and inhibitors of protein kinase C blocked nitrite accumulation in mesangial cells. Nitrites 112-119 nitric oxide synthase 2, inducible Mus musculus 63-67 7756597-3 1995 Treatment with lipopolysaccharide (0.1 micrograms/mL) and interferon-gamma (100 U/mL) for 12 h increased nitrite production from 2.7 +/- 0.2 to 25.4 +/- 1.3 nmol/mg of protein (P < 0.001; N = 9). Nitrites 105-112 interferon gamma Mus musculus 58-74 7756597-4 1995 2,4-Diamino-6-hydroxypyrimidine (6 mM) reduced lipopolysaccharide/interferon-gamma-induced nitrite production by 53.1 +/- 3.4%. Nitrites 91-98 interferon gamma Mus musculus 66-82 7822799-0 1995 Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. Nitrites 123-130 tumor necrosis factor Mus musculus 25-28 7530759-3 1995 Treatment of rat islets with a combination of tumor necrosis factor (TNF) and lipopolysaccharide (LPS), conditions known to activate macrophages, stimulate the expression of iNOS and the formation of nitrite. Nitrites 200-207 tumor necrosis factor-like Rattus norvegicus 46-67 7530759-3 1995 Treatment of rat islets with a combination of tumor necrosis factor (TNF) and lipopolysaccharide (LPS), conditions known to activate macrophages, stimulate the expression of iNOS and the formation of nitrite. Nitrites 200-207 tumor necrosis factor-like Rattus norvegicus 69-72 7733451-0 1995 Sample pretreatment with nitrate reductase and glucose-6-phosphate dehydrogenase quantitatively reduces nitrate while avoiding interference by NADP+ when the Griess reaction is used to assay for nitrite. Nitrites 195-202 glucose-6-phosphate dehydrogenase Homo sapiens 47-80 7829968-6 1995 In addition, IgE IC and anti-CD23 mAb induced, at least in some donors, a production of nitrite that was inhibited in the presence of L-NMMA. Nitrites 88-95 Fc epsilon receptor II Homo sapiens 29-33 7578879-6 1995 The combination IFN-gamma + TNF-alpha caused a 5-fold increase in the medium nitrite accumulation, indicating induction of nitric oxide formation. Nitrites 77-84 interferon gamma Rattus norvegicus 16-25 7578879-6 1995 The combination IFN-gamma + TNF-alpha caused a 5-fold increase in the medium nitrite accumulation, indicating induction of nitric oxide formation. Nitrites 77-84 tumor necrosis factor Rattus norvegicus 28-37 7541501-4 1995 When VSMC were stimulated with a combination of LPS, interferon-gamma (INF) and tumor necrosis factor (TNF) nitrite production was 5-fold greater than with LPS alone. Nitrites 108-115 tumor necrosis factor-like Rattus norvegicus 80-101 7475930-7 1995 Verapamil markedly increased the formation of nitrite in cardiac myocytes in response to LPS and IFN gamma, but not in vascular smooth muscle or mesangial cells. Nitrites 46-53 interferon gamma Rattus norvegicus 97-106 7475946-4 1995 At 1 microM pentamidine, the dose response dependence of nitrite formation on interferon-gamma was not affected. Nitrites 57-64 interferon gamma Mus musculus 78-94 7475946-5 1995 Tumor necrosis factor-alpha caused some enhancement of interferon-gamma-induced nitrite release only at high doses of 100 and 10,000 unit/ml. Nitrites 80-87 tumor necrosis factor Mus musculus 0-27 7475946-5 1995 Tumor necrosis factor-alpha caused some enhancement of interferon-gamma-induced nitrite release only at high doses of 100 and 10,000 unit/ml. Nitrites 80-87 interferon gamma Mus musculus 55-71 7541501-4 1995 When VSMC were stimulated with a combination of LPS, interferon-gamma (INF) and tumor necrosis factor (TNF) nitrite production was 5-fold greater than with LPS alone. Nitrites 108-115 tumor necrosis factor-like Rattus norvegicus 103-106 7544862-3 1995 In addition, in the aortic smooth muscle cells cultured in the presence of Arg, LPS- or IL-1 beta-triggered accumulation of nitrite was suppressed by the tyrosine kinase inhibitors. Nitrites 124-131 interleukin 1 beta Rattus norvegicus 88-97 7527554-5 1994 A COX inhibitor, indomethacin, enhanced IL-1 beta-induced steady-state level of the inducible NOS (iNOS) mRNA and nitrite production. Nitrites 114-121 interleukin 1 beta Rattus norvegicus 40-49 7478126-6 1995 RESULTS: The addition of IFN to dialysis fluid or saline resulted in a significant (P < 0.01) increase in the number of peritoneal macrophages at the time of infection; this was accompanied by a significant increase in both the number of Ia-positive peritoneal macrophages (P < 0.01) and the production of nitrite by macrophages (P < 0.05) at the time. Nitrites 312-319 interferon gamma Rattus norvegicus 25-28 7550551-2 1995 In case of SIN-1 generation of nitrites run in parallel to disappearance of sulfhydryl groups of N-acetylcysteine and glutathione, however, for a pair of SIN-1 and cysteine the rate of formation of nitrites was much slower than the rate of consumption of sulfhydryl groups. Nitrites 31-39 MAPK associated protein 1 Homo sapiens 11-16 7550551-2 1995 In case of SIN-1 generation of nitrites run in parallel to disappearance of sulfhydryl groups of N-acetylcysteine and glutathione, however, for a pair of SIN-1 and cysteine the rate of formation of nitrites was much slower than the rate of consumption of sulfhydryl groups. Nitrites 198-206 MAPK associated protein 1 Homo sapiens 11-16 7527442-7 1994 3) IFN-gamma levels from clone-GdKC-OVA cocultures closely paralleled the nitrite released by GdKCs. Nitrites 74-81 interferon gamma Mus musculus 3-12 7527442-8 1994 4) Only the addition of rIFN-gamma, and not IL-2 or IL-4, to cultures of purified GdKCs resulted in the release of nitrite. Nitrites 115-122 interferon gamma Rattus norvegicus 24-34 7527554-7 1994 In contrast to PGE2, a stable analog of PGI2, carba prostacyclin, enhanced IL-1 beta-induced iNOS mRNA levels and nitrite production. Nitrites 114-121 interleukin 1 beta Rattus norvegicus 75-84 7527832-5 1994 Interestingly, although nitrite accumulation in the culture medium of IMs isolated 48 h after induction of acute endotoxemia and stimulated with low concentrations of IFN-gamma and LPS was reduced, when compared with cells from control animals, these cells, as well as AMs, continued to express high levels of iNOS protein and mRNA. Nitrites 24-31 interferon gamma Rattus norvegicus 167-176 7528998-2 1994 CGRP, in a concentration-dependent manner, enhanced the release of nitrite (a stable oxidation product of NO) and the formation of L-citrulline from L-arginine caused by IL-1 beta. Nitrites 67-74 calcitonin-related polypeptide alpha Rattus norvegicus 0-4 7528998-3 1994 Two cAMP-dependent vasodilators, forskolin and isoproterenol, and the activator of the cAMP-dependent protein kinase, Sp-cAMPS, also enhanced the release of nitrite and the formation of L-citrulline evoked by IL-1 beta. Nitrites 157-164 interleukin 1 beta Rattus norvegicus 209-218 7534188-4 1994 All-trans-retinoic acid (all-trans-RA, 0.1-10 microM) and its active analogues produced concentration-dependent inhibition of IL-1 beta (0.1-10 ng ml-1)-induced nitrite production in cultured VSM cells. Nitrites 161-168 interleukin 1 beta Rattus norvegicus 126-135 7534188-8 1994 TGF-beta produced concentration-dependent (0.1-10 ng ml-1) inhibition of IL-1 beta-induced nitrite production and the maximum effect (approximately 90% inhibition) was significantly greater than that seen with all-trans-RA (approximately 70% with 10 microM). Nitrites 91-98 transforming growth factor, beta 1 Rattus norvegicus 0-8 7534188-8 1994 TGF-beta produced concentration-dependent (0.1-10 ng ml-1) inhibition of IL-1 beta-induced nitrite production and the maximum effect (approximately 90% inhibition) was significantly greater than that seen with all-trans-RA (approximately 70% with 10 microM). Nitrites 91-98 interleukin 1 beta Rattus norvegicus 73-82 7534188-11 1994 In addition to inhibiting IL-1 beta-induced nitrite production, all-trans-RA (10 microM) reduced substantially inducible NOS mRNA and protein levels in IL-1 beta-induced VSM cells (P < 0.01). Nitrites 44-51 interleukin 1 beta Rattus norvegicus 26-35 7534189-8 1994 Accumulation of nitrite (measured by the Griess reaction) was used as an indicator of NO formation and, hence, iNOS activity. Nitrites 16-23 nitric oxide synthase 2 Bos taurus 111-115 7965120-13 1994 In contrast, Hb markedly augmented nitrite accumulation induced by IL-1 beta. Nitrites 35-42 interleukin 1 beta Homo sapiens 67-76 7743368-2 1994 In this pilot study, we wanted to know if the serum values of nitrite/nitrate (NO2/NO3), the stable endproducts of NO biosynthesis, are elevated in patients with septic shock. Nitrites 62-69 NBL1, DAN family BMP antagonist Homo sapiens 83-86 7532078-3 1994 D609 dose-dependently suppressed production of NO, as measured by the release of nitrite and nitrate, in response to lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) in intact cultured cells with an IC50 of approximately 20 micrograms ml-1. Nitrites 81-88 interferon gamma Mus musculus 164-173 7534708-3 1994 Incubation of the culture with interleukin-1 beta (10 ng/ml) for 24 h caused a significant increase in nitrite levels. Nitrites 103-110 interleukin 1 beta Rattus norvegicus 31-49 7534708-4 1994 The basal and interleukin-1 beta-induced nitrite production by vascular smooth muscle cells were not affected by the presence of angiotensin converting enzyme inhibitors (0.1 approximately 10 microM), enalaprilat, cilazaprilat or captopril. Nitrites 41-48 interleukin 1 beta Rattus norvegicus 14-32 7526844-3 1994 Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production. Nitrites 232-239 interleukin 1 beta Rattus norvegicus 178-187 7532082-14 1994 The effect of sper mine on nitrite production can be prevented by isoniazid, hydrazine or hydroxylamine, inhibitors of spermine oxidase, as well as by phenylhydrazine, an aldehyde inhibitor. Nitrites 27-34 spermine oxidase Mus musculus 119-135 7532082-16 1994 Spermine dialdehyde (SDA, 10(-5) M) inhibits nitrite formation by IFN-activated J774.2 cells in the absence of serum when given as a pretreatment but not when given 6 h after stimulation. Nitrites 45-52 interferon gamma Mus musculus 66-69 7531790-1 1994 Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) triggers the expression of a macrophage-type of nitric oxide (NO) synthase and the subsequent increase of cellular concentration of cGMP and nitrite production. Nitrites 224-231 interleukin 1 beta Homo sapiens 52-70 7531790-1 1994 Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) triggers the expression of a macrophage-type of nitric oxide (NO) synthase and the subsequent increase of cellular concentration of cGMP and nitrite production. Nitrites 224-231 interleukin 1 beta Homo sapiens 72-81 7531790-3 1994 Inhibition of GTP-cyclohydrolase I, the rate-limiting enzyme for BH4 synthesis, with 2,4-diamino-6-hydroxy-pyrimidine (DAHP) potently suppresses IL-1 beta-induced nitrite production and elevation of cellular cGMP levels. Nitrites 163-170 GTP cyclohydrolase 1 Rattus norvegicus 14-34 7531790-3 1994 Inhibition of GTP-cyclohydrolase I, the rate-limiting enzyme for BH4 synthesis, with 2,4-diamino-6-hydroxy-pyrimidine (DAHP) potently suppresses IL-1 beta-induced nitrite production and elevation of cellular cGMP levels. Nitrites 163-170 interleukin 1 beta Rattus norvegicus 145-154 7531790-6 1994 N-acetylserotonin, an inhibitor of the BH4 synthetic enzyme sepiapterin reductase, completely abolishes IL-1 beta-stimulated nitrite production, whereas methotrexate, which inhibits the pterin salvage pathway, displays only a moderate inhibitory effect, thus suggesting that mesangial cells predominantly synthesize BH4 by de novo synthesis from GTP. Nitrites 125-132 sepiapterin reductase Rattus norvegicus 60-81 7531790-6 1994 N-acetylserotonin, an inhibitor of the BH4 synthetic enzyme sepiapterin reductase, completely abolishes IL-1 beta-stimulated nitrite production, whereas methotrexate, which inhibits the pterin salvage pathway, displays only a moderate inhibitory effect, thus suggesting that mesangial cells predominantly synthesize BH4 by de novo synthesis from GTP. Nitrites 125-132 interleukin 1 beta Rattus norvegicus 104-113 7846335-9 1994 No correlation was found between TNF-alpha and NO/nitrite, whereas a weak but significant correlation was found between NO/nitrite and concentrations of another cytokine, interleukin-1 beta (IL-1 beta). Nitrites 123-130 interleukin 1 beta Homo sapiens 171-189 7846335-9 1994 No correlation was found between TNF-alpha and NO/nitrite, whereas a weak but significant correlation was found between NO/nitrite and concentrations of another cytokine, interleukin-1 beta (IL-1 beta). Nitrites 123-130 interleukin 1 beta Homo sapiens 191-200 7526844-1 1994 In cultured glomerular mesangial cells, interleukin 1 beta (IL-1 beta) has been shown to induce a dose- and time-dependent accumulation of nitrite, a stable metabolite of nitric oxide (NO). Nitrites 139-146 interleukin 1 beta Rattus norvegicus 40-58 7526844-1 1994 In cultured glomerular mesangial cells, interleukin 1 beta (IL-1 beta) has been shown to induce a dose- and time-dependent accumulation of nitrite, a stable metabolite of nitric oxide (NO). Nitrites 139-146 interleukin 1 beta Rattus norvegicus 60-69 7526844-8 1994 In contrast, a 24 h treatment of mesangial cells with PMA or PDBu, a regimen that also causes depletion of PKC-epsilon, abolished inhibition of IL-1 beta-induced iNOS expression and nitrite production. Nitrites 182-189 interleukin 1 beta Rattus norvegicus 144-153 7524369-4 1994 However, combinations of IFN with either TNF or IL-1 resulted in significant nitrite production; simultaneous stimulation of cells with all three cytokines resulted in significantly increased nitrite production compared with any combination of two cytokines. Nitrites 77-84 interferon gamma Mus musculus 25-28 7523382-3 1994 The NO metabolites nitrite and nitrate rose > 10-fold in medium from stimulated versus unstimulated cells over 24 h. Concomitant with elevated nitrogen oxides, Egr-1 mRNA levels declined to 80% below unstimulated cells at 24 h. This decline was blocked by an inhibitor of NO production, NG-monomethyl-L-arginine. Nitrites 19-26 early growth response 1 Rattus norvegicus 163-168 7524369-4 1994 However, combinations of IFN with either TNF or IL-1 resulted in significant nitrite production; simultaneous stimulation of cells with all three cytokines resulted in significantly increased nitrite production compared with any combination of two cytokines. Nitrites 77-84 tumor necrosis factor Mus musculus 41-44 7524369-4 1994 However, combinations of IFN with either TNF or IL-1 resulted in significant nitrite production; simultaneous stimulation of cells with all three cytokines resulted in significantly increased nitrite production compared with any combination of two cytokines. Nitrites 77-84 interleukin 1 complex Mus musculus 48-52 7524482-6 1994 Thaliporphine (0.1-100 microM) dose-dependently inhibited nitrite accumulation in macrophages stimulated by interleukin-1 beta (IL-1 beta) whereas nitrite formation induced by tumour necrosis factor alpha was not inhibited. Nitrites 58-65 interleukin 1 beta Rattus norvegicus 108-126 7524482-6 1994 Thaliporphine (0.1-100 microM) dose-dependently inhibited nitrite accumulation in macrophages stimulated by interleukin-1 beta (IL-1 beta) whereas nitrite formation induced by tumour necrosis factor alpha was not inhibited. Nitrites 58-65 interleukin 1 beta Rattus norvegicus 128-137 7964313-5 1994 It was found that IL-1 beta induced a marked increase in islet nitrite production, as an index of nitric oxide formation, and that this was paralleled by a decrease in islet glucose oxidation rates. Nitrites 63-70 interleukin 1 beta Rattus norvegicus 18-27 7833830-2 1994 It reduced the rate of methemoglobin formation from oxyhemoglobin exposed to nitric oxide generated from the reaction of hydroxylamine with Complex I of catalase and it decreased the amount of nitrite formed in the reaction of oxygen with nitric oxide generated from sodium nitroprusside. Nitrites 193-200 catalase Rattus norvegicus 153-161 7927208-6 1994 Polyclonal rabbit anti-mouse anti-tumor necrosis factor-alpha reduced in vivo tumor necrosis factor-alpha levels (1 hr, 7,332 +/- 1,492 U tumor necrosis factor-alpha per milliliter) and reduced nitric oxide synthesis as measured by plasma nitrite and nitrate (352 +/- 69 mumol/L). Nitrites 239-246 tumor necrosis factor Mus musculus 34-61 7523451-3 1994 Treatment with IL-1 beta resulted in a marked increase in media nitrite and nitrate accumulation, morphological alterations, and increased release of lactate dehydrogenase (LDH) into media. Nitrites 64-71 interleukin 1 beta Rattus norvegicus 15-24 7523451-6 1994 Similarly, treatment with transforming growth factor beta 1, inhibited IL-1 beta-induced nitrite accumulation, but had no effect on the morphologic or cytotoxic endpoints. Nitrites 89-96 transforming growth factor, beta 1 Rattus norvegicus 26-59 7523451-6 1994 Similarly, treatment with transforming growth factor beta 1, inhibited IL-1 beta-induced nitrite accumulation, but had no effect on the morphologic or cytotoxic endpoints. Nitrites 89-96 interleukin 1 beta Rattus norvegicus 71-80 7858061-2 1994 In addition to induce IgE production, IL-4 was found to elicit nitrite (NO2-) release by PBMC. Nitrites 63-70 interleukin 4 Homo sapiens 38-42 7858061-3 1994 A marked correlation was observed between IgE secretion and nitrite release by PBMC stimulated with an optimal concentration of IL-4. Nitrites 60-67 interleukin 4 Homo sapiens 128-132 7812715-2 1994 The first step of the pathway, the reduction of nitrate to nitrite, is catalyzed by nitrate reductase, a multi-redox cofactor enzyme which belongs to the class of flavoprotein pyridine nucleotide cytochrome reductases. Nitrites 59-66 nitrate reductase [NADH] 1 Zea mays 84-101 7530231-0 1994 Heterogenous nitrite production by IL-4-stimulated human monocytes and peripheral blood mononuclear cells. Nitrites 13-20 interleukin 4 Homo sapiens 35-39 7530231-1 1994 The capacity of human peripheral blood mononuclear cells and monocytes to generate nitrites, spontaneously or in response to Interleukin-4 was evaluated in vitro. Nitrites 83-91 interleukin 4 Homo sapiens 125-138 7530231-4 1994 The present data also indicated that addition of Interleukin-4 generally resulted in an increased nitrite production, that was potentiated by IFN-gamma, inactive alone. Nitrites 98-105 interleukin 4 Homo sapiens 49-62 7530231-4 1994 The present data also indicated that addition of Interleukin-4 generally resulted in an increased nitrite production, that was potentiated by IFN-gamma, inactive alone. Nitrites 98-105 interferon gamma Homo sapiens 142-151 7524699-0 1994 Interleukin-1 beta stimulates nitrite production in the rat ovary: evidence for heterologous cell-cell interaction and for insulin-mediated regulation of the inducible isoform of nitric oxide synthase. Nitrites 30-37 interleukin 1 beta Rattus norvegicus 0-18 7521167-2 1994 Preincubation of human cultured T 67 astrocytoma cells with gp 120 (100-500 nM) produced a significant increase of nitrite (the breakdown product of NO) and PGE2 in cell supernatants. Nitrites 115-122 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 60-66 7521167-3 1994 The effect of gp 120 on both nitrite and PGE2 production was antagonized by inhibition of NO synthase by L-NAME (20-300 microM). Nitrites 29-36 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 14-20 7945814-9 1994 In the presence of anti-TNF antibody, the amounts of superoxide and hydrogen peroxide release were moderately reduced but nitrite release was dramatically inhibited. Nitrites 122-129 tumor necrosis factor Rattus norvegicus 24-27 7524699-2 1994 In an effort to determine whether NO generation mediates any of the intraovarian actions of interleukin-1 beta (IL-1 beta), we have looked for and characterized the accumulation of nitrite by IL-1 beta-treated, cultured whole ovarian dispersates. Nitrites 181-188 interleukin 1 beta Rattus norvegicus 192-201 7524699-3 1994 Application of IL-1 beta significantly enhanced basal nitrite release in a dose-, cell density- and time-dependent manner, the latter characterized by a lag time of about 20 h, suggestive of induction of NO synthase (NOS). Nitrites 54-61 interleukin 1 beta Rattus norvegicus 15-24 7524699-5 1994 Sustained nitrite accumulation required continuous application of IL-1 beta. Nitrites 10-17 interleukin 1 beta Rattus norvegicus 66-75 7524699-6 1994 The maximally stimulating dose of IL-1 beta (50 ng/ml) produced a 10-fold increase in nitrite accumulation by 96 h of culture, an effect reduced 23% when cells were cultured in substrate (i.e., arginine)-free media. Nitrites 86-93 interleukin 1 beta Rattus norvegicus 34-43 7524699-7 1994 IL-1 beta-stimulated nitrite accumulation was reduced to control levels by the simultaneous application of an IL-1 beta receptor antagonist, thereby suggesting a specific receptor-mediated effect. Nitrites 21-28 interleukin 1 beta Rattus norvegicus 0-9 7524699-7 1994 IL-1 beta-stimulated nitrite accumulation was reduced to control levels by the simultaneous application of an IL-1 beta receptor antagonist, thereby suggesting a specific receptor-mediated effect. Nitrites 21-28 interleukin 1 beta Rattus norvegicus 110-119 7524699-8 1994 Both the control and IL-1 beta-stimulated levels of nitrite accumulation were attenuated in a dose-dependent manner by inhibitors that favor the inducible form of NOS. Nitrites 52-59 interleukin 1 beta Rattus norvegicus 21-30 7524699-11 1994 IL-1 beta-induced nitrite accumulation was shown to require cell-cell interaction between granulosa and theca-interstitial cells. Nitrites 18-25 interleukin 1 beta Rattus norvegicus 0-9 7519531-10 1994 This study demonstrates that there is in vivo induction of iNOS in immune complex glomerulonephritis, corresponding to the generation of nitrite we have previously reported. Nitrites 137-144 nitric oxide synthase 2 Rattus norvegicus 59-63 7530664-8 1994 Nitrite, a stable endproduct of NO formation by cells, was detectable in the culture supernatants after 18-24 hr of exposure to interferon-gamma and lipopolysaccharide, and continued to accumulate in a linear fashion for at least 96 hr. Nitrites 0-7 interferon gamma Mus musculus 128-144 7530664-9 1994 Treatment of cultured retinal pigment epithelium with interferon-gamma, lipopolysaccharide and either basic fibroblast growth factor or epidermal growth factor as third signals augmented inducible nitric oxide synthase expression as evidenced by intensified signals on immunoblots, enhanced accumulation of nitrite and increased iNOS enzyme activity. Nitrites 307-314 interferon gamma Mus musculus 54-70 7518807-12 1994 Nitrite production was induced in X-irradiated, strain EVir-infected L929 cell cultures treated with TNF-alpha alone or IFN-gamma alone; however, more nitrite was produced in infected cultures treated with IFN-gamma plus TNF-alpha. Nitrites 0-7 tumor necrosis factor Mus musculus 101-110 7518807-12 1994 Nitrite production was induced in X-irradiated, strain EVir-infected L929 cell cultures treated with TNF-alpha alone or IFN-gamma alone; however, more nitrite was produced in infected cultures treated with IFN-gamma plus TNF-alpha. Nitrites 0-7 interferon gamma Mus musculus 120-129 7518807-12 1994 Nitrite production was induced in X-irradiated, strain EVir-infected L929 cell cultures treated with TNF-alpha alone or IFN-gamma alone; however, more nitrite was produced in infected cultures treated with IFN-gamma plus TNF-alpha. Nitrites 0-7 interferon gamma Mus musculus 206-215 7518807-12 1994 Nitrite production was induced in X-irradiated, strain EVir-infected L929 cell cultures treated with TNF-alpha alone or IFN-gamma alone; however, more nitrite was produced in infected cultures treated with IFN-gamma plus TNF-alpha. Nitrites 0-7 tumor necrosis factor Mus musculus 221-230 7518807-12 1994 Nitrite production was induced in X-irradiated, strain EVir-infected L929 cell cultures treated with TNF-alpha alone or IFN-gamma alone; however, more nitrite was produced in infected cultures treated with IFN-gamma plus TNF-alpha. Nitrites 151-158 interferon gamma Mus musculus 206-215 7518807-12 1994 Nitrite production was induced in X-irradiated, strain EVir-infected L929 cell cultures treated with TNF-alpha alone or IFN-gamma alone; however, more nitrite was produced in infected cultures treated with IFN-gamma plus TNF-alpha. Nitrites 151-158 tumor necrosis factor Mus musculus 221-230 7530664-9 1994 Treatment of cultured retinal pigment epithelium with interferon-gamma, lipopolysaccharide and either basic fibroblast growth factor or epidermal growth factor as third signals augmented inducible nitric oxide synthase expression as evidenced by intensified signals on immunoblots, enhanced accumulation of nitrite and increased iNOS enzyme activity. Nitrites 307-314 fibroblast growth factor 2 Mus musculus 102-132 7739201-7 1994 IL-1 alpha increased nitrite release in a dose-dependent fashion and a significant enhancement (p < 0.01) was attained at 10 U/ml. Nitrites 21-28 interleukin 1 alpha Homo sapiens 0-10 7518842-7 1994 Using a myocardial cytosolic iNOS preparation, nitrite formation from L-arginine and [3H] citrulline formation from [3H]L-arginine were increased significantly in the rejecting allogeneic grafts (P < 0.01). Nitrites 47-54 nitric oxide synthase 2 Rattus norvegicus 29-33 7739201-8 1994 OBs released 14.2 nmol/4.0 x 10(4) cells of nitrite after 72 hrs stimulation by 100 U/ml IL-1 alpha. Nitrites 44-51 interleukin 1 alpha Homo sapiens 89-99 20692968-4 1994 Addition of nitrite to the MPO/H(2)O(2) system markedly increased the formation of (+)-anti-BPDE. Nitrites 12-19 myeloperoxidase Homo sapiens 27-30 8027551-5 1994 rIFN-gamma-induced antimicrobial effects in AM correlated with amount of nitrites produced, but nitric oxide played only a minimal role in antibacterial effects induced in AM, because NG-MMLA (specific inhibitor of L-arginine-dependent nitric oxide production) failed to block antimicrobial activity of IFN-gamma-stimulated AM. Nitrites 73-81 interferon gamma Rattus norvegicus 0-10 8027551-5 1994 rIFN-gamma-induced antimicrobial effects in AM correlated with amount of nitrites produced, but nitric oxide played only a minimal role in antibacterial effects induced in AM, because NG-MMLA (specific inhibitor of L-arginine-dependent nitric oxide production) failed to block antimicrobial activity of IFN-gamma-stimulated AM. Nitrites 73-81 interferon gamma Rattus norvegicus 1-10 20692968-5 1994 Taken together, the results indicate that the principal pathway for the nitrite-stimulated formation of (+)-anti-BPDE in PMA-activated PMNs involves participation of MPO, whereas alternative pathways seem to be operative in the formation of BP-7,8-dione. Nitrites 72-79 myeloperoxidase Homo sapiens 166-169 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitrites 165-172 interleukin 1 beta Rattus norvegicus 48-66 7518670-2 1994 BAF increased intravesicular pH and enhanced nitrite release by activated macrophages; however, the NO concentration necessary to kill parasites was higher in BAF-exposed than control macrophages, suggesting that microbicidal nitrogen derivatives were less active at alkaline pH. Nitrites 45-52 BAF nuclear assembly factor 1 Homo sapiens 0-3 7518670-3 1994 Antibody to tumour necrosis factor alpha inhibited BAF-induced nitrite production in interferon-activated cultures. Nitrites 63-70 BAF nuclear assembly factor 1 Homo sapiens 51-54 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitrites 165-172 interleukin 1 beta Rattus norvegicus 68-77 7519400-4 1994 Both the expression of iNOS and nitrite formation induced by IL-1 beta were prevented by the mRNA transcriptional inhibitor actinomycin D. Nitrites 32-39 interleukin 1 beta Rattus norvegicus 61-70 7519400-6 1994 The tyrosine kinase inhibitors genistein and herbimycin A prevented IL-1 beta-induced expression of immunoprecipitable iNOS and nitrite release by islets, by insulinoma RINm5F cells, and by FACS-purified beta-cells. Nitrites 128-135 interleukin 1 beta Rattus norvegicus 68-77 7525477-2 1994 This induction can be measured by assaying cyclic GMP levels in the cultures, which correlates with, but is more sensitive than, measurement of nitrite accumulation. Nitrites 144-151 5'-nucleotidase, cytosolic II Homo sapiens 50-53 8033406-4 1994 Various levels of nitrite production were achieved by activating macrophages with interferon-gamma (IFN-gamma) (20 or 500 U/ml) with or without lipopolysaccharide (LPS) (10 ng/ml) for 20 h before the Listericidal assay, and by using normal and arginine-free culture medium during the Listericidal assay. Nitrites 18-25 interferon gamma Mus musculus 82-98 8033406-4 1994 Various levels of nitrite production were achieved by activating macrophages with interferon-gamma (IFN-gamma) (20 or 500 U/ml) with or without lipopolysaccharide (LPS) (10 ng/ml) for 20 h before the Listericidal assay, and by using normal and arginine-free culture medium during the Listericidal assay. Nitrites 18-25 interferon gamma Mus musculus 100-109 7959883-0 1994 Nitrite production by macrophages derived from BCG-resistant and -susceptible congenic mouse strains in response to IFN-gamma and infection with BCG. Nitrites 0-7 interferon gamma Mus musculus 116-125 7959883-9 1994 Addition of L-arginine to IFN-gamma-stimulated macrophages in the presence of NgMMLA restored nitrite production and bacteriostatic activity of macrophages. Nitrites 94-101 interferon gamma Mus musculus 26-35 7947461-8 1994 CD23-ligation also induced the production of nitrites by these cells. Nitrites 45-53 Fc epsilon receptor II Homo sapiens 0-4 7521071-2 1994 Treatment of vascular SMC with IL-1 beta stimulated iNOS mRNA expression and the subsequent release of nitrite, a stable oxidation product of nitric oxide (NO). Nitrites 103-110 interleukin 1 beta Rattus norvegicus 31-40 7515948-2 1994 Treatment of retinal Muller glial (RMG) cells with lipopolysaccharide (LPS), interferon-gamma, and tumor necrosis factor-alpha induced NO synthesis as determined by nitrite release in media. Nitrites 165-172 interferon gamma Rattus norvegicus 77-126 7521071-4 1994 The addition of IL-1 beta and cAMP derivatives resulted in a synergistic enhancement of both iNOS mRNA production and of nitrite formation. Nitrites 121-128 interleukin 1 beta Rattus norvegicus 16-25 7515501-2 1994 Stimulation with IL-1 beta alone leads to an approximately 40-fold increase in NOS activity and nitrite synthesis, whereas the elevation of cAMP with forskolin, cholera toxin, salbutamol, or dibutyryl-cAMP for 24 h resulted in a 2- to 12-fold increase in NOS activity. Nitrites 96-103 interleukin 1 beta Rattus norvegicus 17-26 8003032-2 1994 TNF alpha, IL-1 beta, and LPS caused a dose- and time-dependent increase of nitrite (NO2-), the stable metabolite of nitric oxide (NO), in conditioned media over 48 hours, while IFN gamma had a minimal effect. Nitrites 76-83 tumor necrosis factor Mus musculus 0-9 8003032-2 1994 TNF alpha, IL-1 beta, and LPS caused a dose- and time-dependent increase of nitrite (NO2-), the stable metabolite of nitric oxide (NO), in conditioned media over 48 hours, while IFN gamma had a minimal effect. Nitrites 76-83 interleukin 1 beta Mus musculus 11-20 7526665-5 1994 Concomitantly, NaNP decreased the release of histamine while increasing the release of nitrite. Nitrites 87-94 N-acylneuraminate-9-phosphatase Cavia porcellus 15-19 8081534-3 1994 These substances have been associated with significant hemolysis of red blood cells in patients with decreased or normal glucose-6-phosphate dehydrogenase levels because such nitrites act as cell-membrane oxidants. Nitrites 175-183 glucose-6-phosphate dehydrogenase Homo sapiens 121-154 18966013-3 1994 In contrast, membranes containing Co(III) porphyrins require the addition of lipophilic cationic sites (e.g. tridodecylmethylammonium ions) in order to achieve optimal anion selectivity (for nitrite and thiocyanate) as well as rapid and reversible Nernstian response toward these anionic species. Nitrites 191-198 mitochondrially encoded cytochrome c oxidase III Homo sapiens 34-41 7522713-4 1994 CD23-ligation activates the nitric oxide-dependent pathway, as demonstrated by the high levels of nitrites released in cell supernatants, and the accumulation of intracellular cyclic nucleotides in EK. Nitrites 98-106 Fc epsilon receptor II Homo sapiens 0-4 7514598-6 1994 Time course studies showed that nitrite was first detected in culture fluid about 8 h after endotoxin stimulation, and it accumulated at a linear rate during the ensuing 16 h. Inhibition by MSP occurred during the 8-h lipopolysaccharide (LPS) induction period; inhibition was maximal when MSP and LPS were added together and decreased progressively to no inhibition as the interval between LPS and MSP addition increased to 11 h. Nitrites 32-39 macrophage stimulating 1 (hepatocyte growth factor-like) Mus musculus 190-193 7514598-6 1994 Time course studies showed that nitrite was first detected in culture fluid about 8 h after endotoxin stimulation, and it accumulated at a linear rate during the ensuing 16 h. Inhibition by MSP occurred during the 8-h lipopolysaccharide (LPS) induction period; inhibition was maximal when MSP and LPS were added together and decreased progressively to no inhibition as the interval between LPS and MSP addition increased to 11 h. Nitrites 32-39 macrophage stimulating 1 (hepatocyte growth factor-like) Mus musculus 289-292 7514598-6 1994 Time course studies showed that nitrite was first detected in culture fluid about 8 h after endotoxin stimulation, and it accumulated at a linear rate during the ensuing 16 h. Inhibition by MSP occurred during the 8-h lipopolysaccharide (LPS) induction period; inhibition was maximal when MSP and LPS were added together and decreased progressively to no inhibition as the interval between LPS and MSP addition increased to 11 h. Nitrites 32-39 macrophage stimulating 1 (hepatocyte growth factor-like) Mus musculus 289-292 7514190-6 1994 Combinations of cytokines, notably IL-1 beta plus IFN-gamma plus TNF-alpha, induced increased expression of inducible NO synthase mRNA after 6 h and resulted in a fivefold increase in medium nitrite accumulation after 48 h. These cytokines did not impair glucose metabolism or insulin release in response to 16.7 mM glucose, but there was an 80% decrease in islet insulin content. Nitrites 191-198 tumor necrosis factor Homo sapiens 65-74 7518300-15 1994 Combination of Bt2 cyclic AMP and IL-1 beta or TNF alpha revealed a strong synergy in terms of nitrite formation. Nitrites 95-102 interleukin 1 beta Rattus norvegicus 34-43 7518300-15 1994 Combination of Bt2 cyclic AMP and IL-1 beta or TNF alpha revealed a strong synergy in terms of nitrite formation. Nitrites 95-102 tumor necrosis factor Rattus norvegicus 47-56 7518300-16 1994 Time-course studies indicated that cyclic AMP needed to be increased during the whole period of IL-1 Beta stimulation for maximal nitrite production.7. Nitrites 130-137 interleukin 1 beta Rattus norvegicus 96-105 8045593-4 1994 Only macrophages plated onto fibrinogen also released measurable levels of nitrites, again higher in Lshr compared to Lshs macrophages. Nitrites 75-83 luteinizing hormone/choriogonadotropin receptor Mus musculus 101-105 8045593-5 1994 Addition of interferon-gamma (IFN-gamma), but not bacterial lipopolysaccharide or mycobacterial lipoarabinomannan, as a second signal enhanced the TNF-alpha and nitrite responses of macrophages plated onto fibrinogen, particularly in the Lshr macrophages. Nitrites 161-168 interferon gamma Mus musculus 12-28 8045593-5 1994 Addition of interferon-gamma (IFN-gamma), but not bacterial lipopolysaccharide or mycobacterial lipoarabinomannan, as a second signal enhanced the TNF-alpha and nitrite responses of macrophages plated onto fibrinogen, particularly in the Lshr macrophages. Nitrites 161-168 interferon gamma Mus musculus 30-39 8045593-6 1994 Interaction with fibrinogen and fibronectin also primed macrophages for an enhanced TNF-alpha response to leishmanial parasites, but this was only translated into enhanced nitrite responses in the presence of IFN-gamma. Nitrites 172-179 fibronectin 1 Mus musculus 32-43 7514190-6 1994 Combinations of cytokines, notably IL-1 beta plus IFN-gamma plus TNF-alpha, induced increased expression of inducible NO synthase mRNA after 6 h and resulted in a fivefold increase in medium nitrite accumulation after 48 h. These cytokines did not impair glucose metabolism or insulin release in response to 16.7 mM glucose, but there was an 80% decrease in islet insulin content. Nitrites 191-198 interleukin 1 beta Homo sapiens 35-44 7514190-6 1994 Combinations of cytokines, notably IL-1 beta plus IFN-gamma plus TNF-alpha, induced increased expression of inducible NO synthase mRNA after 6 h and resulted in a fivefold increase in medium nitrite accumulation after 48 h. These cytokines did not impair glucose metabolism or insulin release in response to 16.7 mM glucose, but there was an 80% decrease in islet insulin content. Nitrites 191-198 interferon gamma Homo sapiens 50-59 7512570-2 1994 A potent vasoconstrictor, angiotensin II (Ang II), which causes a rapid phospholipase C-mediated phosphoinositide hydrolysis via the Ang II type 1 (AT1) receptor in VSMC, by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose dependently inhibited the IL-1 beta-induced nitrite production. Nitrites 217-224 angiotensinogen Homo sapiens 26-40 8182161-4 1994 CD23-ligation activates the nitric oxide-dependent pathway, as demonstrated by the high levels of nitrites released in cell supernatants, and the accumulation of intracellular cyclic nucleotides in EK. Nitrites 98-106 Fc epsilon receptor II Homo sapiens 0-4 7512570-2 1994 A potent vasoconstrictor, angiotensin II (Ang II), which causes a rapid phospholipase C-mediated phosphoinositide hydrolysis via the Ang II type 1 (AT1) receptor in VSMC, by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose dependently inhibited the IL-1 beta-induced nitrite production. Nitrites 217-224 angiotensinogen Homo sapiens 42-48 7512570-2 1994 A potent vasoconstrictor, angiotensin II (Ang II), which causes a rapid phospholipase C-mediated phosphoinositide hydrolysis via the Ang II type 1 (AT1) receptor in VSMC, by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose dependently inhibited the IL-1 beta-induced nitrite production. Nitrites 217-224 angiotensinogen Homo sapiens 133-139 7512570-2 1994 A potent vasoconstrictor, angiotensin II (Ang II), which causes a rapid phospholipase C-mediated phosphoinositide hydrolysis via the Ang II type 1 (AT1) receptor in VSMC, by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose dependently inhibited the IL-1 beta-induced nitrite production. Nitrites 217-224 angiotensin II receptor type 1 Homo sapiens 148-151 7512570-2 1994 A potent vasoconstrictor, angiotensin II (Ang II), which causes a rapid phospholipase C-mediated phosphoinositide hydrolysis via the Ang II type 1 (AT1) receptor in VSMC, by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose dependently inhibited the IL-1 beta-induced nitrite production. Nitrites 306-313 angiotensinogen Homo sapiens 26-40 7512570-2 1994 A potent vasoconstrictor, angiotensin II (Ang II), which causes a rapid phospholipase C-mediated phosphoinositide hydrolysis via the Ang II type 1 (AT1) receptor in VSMC, by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose dependently inhibited the IL-1 beta-induced nitrite production. Nitrites 306-313 angiotensinogen Homo sapiens 42-48 7512570-2 1994 A potent vasoconstrictor, angiotensin II (Ang II), which causes a rapid phospholipase C-mediated phosphoinositide hydrolysis via the Ang II type 1 (AT1) receptor in VSMC, by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose dependently inhibited the IL-1 beta-induced nitrite production. Nitrites 306-313 angiotensinogen Homo sapiens 133-139 7512570-2 1994 A potent vasoconstrictor, angiotensin II (Ang II), which causes a rapid phospholipase C-mediated phosphoinositide hydrolysis via the Ang II type 1 (AT1) receptor in VSMC, by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose dependently inhibited the IL-1 beta-induced nitrite production. Nitrites 306-313 angiotensin II receptor type 1 Homo sapiens 148-151 7512570-6 1994 Ang II also inhibited increases in nitrite production and iNOS mRNA and protein levels caused by tumor necrosis factor alpha. Nitrites 35-42 angiotensinogen Homo sapiens 0-6 7512570-7 1994 A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol. Nitrites 186-193 interleukin 1 beta Homo sapiens 168-177 7514363-4 1994 IL-1 beta, TNF-alpha, and LPS each induced NO synthase activity, assessed by release of nitrite, conversion of L-arginine to L-citrulline, and increased levels of guanosine 3",5"-cyclic monophosphate, whereas IL-2, IL-6, and interferon-gamma were ineffective. Nitrites 88-95 interleukin 1 beta Rattus norvegicus 0-9 8178348-5 1994 Nitrite levels in the medium (indirect measure of NO) after islets were cultured for a 24-hr period were nearly 3-fold greater in IL-1 beta-exposed islets than control islet cultures (5.8 +/- 1.0 microM vs. 2.2 +/- 0.3 microM, P = 0.03). Nitrites 0-7 interleukin 1 beta Rattus norvegicus 130-139 8178348-6 1994 Production of nitrite by islet cells in the presence of IL-1 beta was inhibited in cultures also containing 2 mM L-NG-monomethyl-Arginine (L-NMMA) (3.4 +/- 0.4 microM, n = 9, P = 0.09 vs. control). Nitrites 14-21 interleukin 1 beta Rattus norvegicus 56-65 7514363-4 1994 IL-1 beta, TNF-alpha, and LPS each induced NO synthase activity, assessed by release of nitrite, conversion of L-arginine to L-citrulline, and increased levels of guanosine 3",5"-cyclic monophosphate, whereas IL-2, IL-6, and interferon-gamma were ineffective. Nitrites 88-95 tumor necrosis factor Rattus norvegicus 11-20 7802762-10 1994 LPS and cytokine-induced NO production, determined by nitrite concentrations in the medium, was decreased in a concentration-dependent manner by the GTP-CH inhibitor, 2,4-diamino-6-hydroxypyrimidine (DAHP) at 24 h. DAHP also inhibited completely the LPS- and cytokine-induced accumulation of intracellular biopterins. Nitrites 54-61 GTP cyclohydrolase 1 Rattus norvegicus 149-155 8180968-5 1994 Preliminary experiments suggest that nitrite stimulates the metabolism of (-)-BP-7,8-diol by direct interaction with myeloperoxidase and hydrogen peroxide. Nitrites 37-44 myeloperoxidase Homo sapiens 117-132 8142651-3 1994 Treatment of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite in the culture media and in marked elevation of intracellular cyclic guanosine monophosphate (GMP) levels. Nitrites 97-104 interleukin 1 beta Homo sapiens 47-56 8142651-4 1994 The releasate from collagen-aggregated platelets blocked the IL-1 beta-mediated production of nitrite and the accumulation of cyclic GMP in smooth muscle cells in a platelet number-dependent manner. Nitrites 94-101 interleukin 1 beta Homo sapiens 61-70 8163651-4 1994 In this study we show that primary rat osteoblast-like cells as well as the clonal rat osteoblast-like cell line UMR-106, stimulated with IFN-gamma together with TNF-alpha and LPS, produce NO, measured as nitrite production. Nitrites 205-212 interferon gamma Rattus norvegicus 138-147 8163651-4 1994 In this study we show that primary rat osteoblast-like cells as well as the clonal rat osteoblast-like cell line UMR-106, stimulated with IFN-gamma together with TNF-alpha and LPS, produce NO, measured as nitrite production. Nitrites 205-212 toll-like receptor 4 Mus musculus 176-179 8163651-7 1994 The competitive inhibitor of NO production, NG-monomethyl-arginine (L-NMMA), and cycloheximide abolished the increase in nitrite production induced by TNF-alpha + IFN-gamma + LPS, while hydrocortisone had no effect, as previously reported for chondrocytes. Nitrites 121-128 tumor necrosis factor Mus musculus 151-160 8163651-7 1994 The competitive inhibitor of NO production, NG-monomethyl-arginine (L-NMMA), and cycloheximide abolished the increase in nitrite production induced by TNF-alpha + IFN-gamma + LPS, while hydrocortisone had no effect, as previously reported for chondrocytes. Nitrites 121-128 interferon gamma Mus musculus 163-172 8163651-7 1994 The competitive inhibitor of NO production, NG-monomethyl-arginine (L-NMMA), and cycloheximide abolished the increase in nitrite production induced by TNF-alpha + IFN-gamma + LPS, while hydrocortisone had no effect, as previously reported for chondrocytes. Nitrites 121-128 toll-like receptor 4 Mus musculus 175-178 8064164-6 1994 RESULTS: The formation of nitrite and cGMP was significantly increased after incubation of mesangial cells with interleukin-1 beta or lipopolysaccharide. Nitrites 26-33 interleukin 1 beta Rattus norvegicus 112-130 8064164-15 1994 CONCLUSIONS: The present findings support recent observations that interleukin-1 beta and lipopolysaccharide strongly induce NO production in mesangial cells, as is shown indirectly by the greatly increased formation of nitrite and cGMP. Nitrites 220-227 interleukin 1 beta Rattus norvegicus 67-85 8135804-2 1994 Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in the increased accumulation of nitrite in the medium. Nitrites 203-210 interferon gamma Mus musculus 131-147 7511593-9 1994 In addition, IL-4 induced an increased secretion of nitrite by monocytes, that was potentiated by IFN-gamma and inhibited by L-NMMA. Nitrites 52-59 interleukin 4 Homo sapiens 13-17 7511593-9 1994 In addition, IL-4 induced an increased secretion of nitrite by monocytes, that was potentiated by IFN-gamma and inhibited by L-NMMA. Nitrites 52-59 interferon gamma Homo sapiens 98-107 8136351-0 1994 EPR and electron nuclear double resonance (ENDOR) studies show nitrite binding to the type 2 copper centers of the dissimilatory nitrite reductase of Alcaligenes xylosoxidans (NCIMB 11015). Nitrites 63-70 nitrite reductase large subunit Achromobacter xylosoxidans 129-146 8135804-2 1994 Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in the increased accumulation of nitrite in the medium. Nitrites 203-210 interferon gamma Rattus norvegicus 149-159 7521274-5 1994 Both CsA and FK506 (at 1 mumol/L) significantly inhibited nitrite production induced by recombinant murine interleukin-1 beta (rIL-1 beta). Nitrites 58-65 interleukin 1 beta Mus musculus 107-125 8144903-4 1994 LPS and IFN-gamma alone and in combination markedly stimulated putrescine export and nitrite production throughout a 24-h period. Nitrites 85-92 interferon gamma Mus musculus 8-17 7521274-5 1994 Both CsA and FK506 (at 1 mumol/L) significantly inhibited nitrite production induced by recombinant murine interleukin-1 beta (rIL-1 beta). Nitrites 58-65 interleukin 1 beta Rattus norvegicus 127-137 7509602-3 1994 Stimulation with cytomix, a combination of interleukin-1 beta, tumor necrosis factor-alpha, and interferon-gamma, elevated nitrite levels by 873% in the culture supernatants and enhanced the conversion of arginine to citrulline by 273% at 24 h. An increased number of cells stained for iNOS and an increase in iNOS mRNA was also observed. Nitrites 123-130 interleukin 1 beta Mus musculus 43-90 7509602-3 1994 Stimulation with cytomix, a combination of interleukin-1 beta, tumor necrosis factor-alpha, and interferon-gamma, elevated nitrite levels by 873% in the culture supernatants and enhanced the conversion of arginine to citrulline by 273% at 24 h. An increased number of cells stained for iNOS and an increase in iNOS mRNA was also observed. Nitrites 123-130 interferon gamma Mus musculus 96-112 8032008-3 1994 It has been shown earlier that IL-1 beta will stimulate the production of nitrite in such cells. Nitrites 74-81 interleukin 1 beta Rattus norvegicus 31-40 7508220-5 1994 Hepatocyte iNOS messenger RNA (mRNA) levels were correlated with iNOS activity and circulating plasma nitrite and nitrate levels. Nitrites 102-109 nitric oxide synthase 2 Rattus norvegicus 11-15 8032008-5 1994 However, the tyrosine kinase antagonist tyrphostin inhibited, whereas sodium orthovanadate, okadaic acid and cyclosporin A, all inhibitors of protein phosphatases, potentiated IL-1 beta induced nitrite release to the medium. Nitrites 194-201 interleukin 1 beta Rattus norvegicus 176-185 7509393-6 1994 Nitrite concentration in the incubation medium was increased after IFN-gamma, which indicates the induction of nitric oxide release during the incubation period. Nitrites 0-7 interferon gamma Bos taurus 67-76 7507417-7 1994 One potential mechanism that may contribute to the enhanced production of nitrite in vessels from exercised dogs may be the induction of the calcium-dependent ECNOS gene. Nitrites 74-81 nitric oxide synthase 3 Canis lupus familiaris 159-164 7507509-3 1994 MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains. Nitrites 39-46 Fas (TNF receptor superfamily member 6) Mus musculus 4-7 7507509-3 1994 MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains. Nitrites 39-46 Fas (TNF receptor superfamily member 6) Mus musculus 8-11 7507509-3 1994 MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains. Nitrites 39-46 Fas (TNF receptor superfamily member 6) Mus musculus 8-11 7507509-3 1994 MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains. Nitrites 39-46 Fas (TNF receptor superfamily member 6) Mus musculus 8-11 7508388-13 1994 In turn, mutational inactivation of the structural gene for cytochrome cd1, nirS, or loss of in vivo nitrite reduction by mutation of the nirT gene, encoding a presumed tetraheme cytochrome, lowered the expression level of NO reductase to 5-20%, but hardly its catalytic activity. Nitrites 101-108 cbb3-type cytochrome c oxidase subunit I Pseudomonas stutzeri 223-235 8185875-6 1994 The principle component of the coating is nitrite ion, which in the presence of ozone is oxidized to nitrate ion on the filter medium (NO2- + O3 produces NO3- + O2). Nitrites 42-49 NBL1, DAN family BMP antagonist Homo sapiens 154-157 7508388-14 1994 The cellular concentration of NO reductase increased again on restoration of nitrite reduction in the nirS::Tn5 mutant MK202 by complementation with nirS or with the heterologous nirK gene, encoding the Cu-containing nitrite reductase from Pseudomonas aureofaciens. Nitrites 77-84 cbb3-type cytochrome c oxidase subunit I Pseudomonas stutzeri 30-42 7578850-3 1994 IL-1 beta, but not TNF-alpha, induced an increase in nitrite production, which was significantly reduced by the competitive inhibitor of nitric oxide synthase L-NG-monomethyl-arginine (L-NMMA) (0.1 mmol/L and 0.5 mmol/L). Nitrites 53-60 interleukin 1 beta Homo sapiens 0-9 7534178-3 1994 AII by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose-dependently inhibited IL1 beta-induced nitrite production. Nitrites 134-141 angiotensinogen Homo sapiens 0-3 7534178-3 1994 AII by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose-dependently inhibited IL1 beta-induced nitrite production. Nitrites 134-141 interleukin 1 beta Homo sapiens 117-125 7534178-5 1994 In parallel with the decrease in nitrite production, AII suppressed IL1 beta-induced increases in iNOS mRNA and protein levels, as measured by Northern blotting using an iNOS cDNA probe and by immunoblotting using an anti-iNOS antibody, respectively. Nitrites 33-40 angiotensinogen Homo sapiens 53-56 7534178-5 1994 In parallel with the decrease in nitrite production, AII suppressed IL1 beta-induced increases in iNOS mRNA and protein levels, as measured by Northern blotting using an iNOS cDNA probe and by immunoblotting using an anti-iNOS antibody, respectively. Nitrites 33-40 interleukin 1 beta Homo sapiens 68-76 7534178-6 1994 AII also inhibited the increases in nitrite production and iNOS mRNA and protein levels caused by TNF alpha. Nitrites 36-43 angiotensinogen Homo sapiens 0-3 7516691-4 1994 Besides employing TPA directly, the synergistic effect of TNF could be traced back to protein kinase C activation since protein kinase C inhibitors (IC50 value for staurosporine: 4 nM) potently suppressed nitrite production in the case of IL-1/TNF administration. Nitrites 205-212 tumor necrosis factor Rattus norvegicus 58-61 7516691-5 1994 Further experiments using anti-TNF antibodies aimed to an autocrine loop following IL-1 addition to RINm5F cells, possibly involved in nitrite generation. Nitrites 135-142 tumor necrosis factor Rattus norvegicus 31-34 7505207-4 1994 IGF-I inhibited, in a concentration-dependent manner, the production of nitrite and L-citrulline evoked by IL-1 beta or TNF-alpha. Nitrites 72-79 insulin-like growth factor 1 Rattus norvegicus 0-5 7505207-4 1994 IGF-I inhibited, in a concentration-dependent manner, the production of nitrite and L-citrulline evoked by IL-1 beta or TNF-alpha. Nitrites 72-79 interleukin 1 beta Rattus norvegicus 107-116 7505207-4 1994 IGF-I inhibited, in a concentration-dependent manner, the production of nitrite and L-citrulline evoked by IL-1 beta or TNF-alpha. Nitrites 72-79 tumor necrosis factor Rattus norvegicus 120-129 7505207-6 1994 Two IGF-I-related proteins, IGF-II and insulin, also inhibited, but to a smaller extent, the release of nitrite and the formation of L-citrulline stimulated by IL-1 beta. Nitrites 104-111 insulin-like growth factor 1 Rattus norvegicus 4-9 7505207-6 1994 Two IGF-I-related proteins, IGF-II and insulin, also inhibited, but to a smaller extent, the release of nitrite and the formation of L-citrulline stimulated by IL-1 beta. Nitrites 104-111 insulin-like growth factor 2 Rattus norvegicus 28-34 7505207-6 1994 Two IGF-I-related proteins, IGF-II and insulin, also inhibited, but to a smaller extent, the release of nitrite and the formation of L-citrulline stimulated by IL-1 beta. Nitrites 104-111 interleukin 1 beta Rattus norvegicus 160-169 7506700-2 1994 Interferon gamma, tumor necrosis factor-alpha, and interleukin-1 beta each markedly increased mRNA and protein levels of this enzyme in parallel with the production of nitrite, a stable oxidative metabolite of nitric oxide. Nitrites 168-175 interferon gamma Homo sapiens 0-45 7506700-2 1994 Interferon gamma, tumor necrosis factor-alpha, and interleukin-1 beta each markedly increased mRNA and protein levels of this enzyme in parallel with the production of nitrite, a stable oxidative metabolite of nitric oxide. Nitrites 168-175 interleukin 1 beta Homo sapiens 51-69 7506700-5 1994 Transforming growth factor-beta 1, which inhibited the interferon gamma-, interleukin-1 beta-, and tumor necrosis factor-alpha-induced nitrite production, did not affect the increases in mRNA levels caused by these cytokines. Nitrites 135-142 transforming growth factor beta 1 Homo sapiens 0-33 7506700-5 1994 Transforming growth factor-beta 1, which inhibited the interferon gamma-, interleukin-1 beta-, and tumor necrosis factor-alpha-induced nitrite production, did not affect the increases in mRNA levels caused by these cytokines. Nitrites 135-142 tumor necrosis factor Homo sapiens 55-126 7505613-6 1993 Treatment of rat islets with 5 units/mL IL-1 beta induces a similar time-dependent production of both nitrite and PGE2. Nitrites 102-109 interleukin 1 beta Rattus norvegicus 40-49 7512249-2 1993 We demonstrate by immunoprecipitation and nitrite formation that interleukin-1 beta (IL1 beta) plus interferon-gamma (INF gamma) induce the expression of nitric oxide synthase in primary cultures of murine cortical astrocytes. Nitrites 42-49 interleukin 1 beta Mus musculus 65-83 7512249-2 1993 We demonstrate by immunoprecipitation and nitrite formation that interleukin-1 beta (IL1 beta) plus interferon-gamma (INF gamma) induce the expression of nitric oxide synthase in primary cultures of murine cortical astrocytes. Nitrites 42-49 interleukin 1 beta Mus musculus 85-93 7512249-2 1993 We demonstrate by immunoprecipitation and nitrite formation that interleukin-1 beta (IL1 beta) plus interferon-gamma (INF gamma) induce the expression of nitric oxide synthase in primary cultures of murine cortical astrocytes. Nitrites 42-49 interferon gamma Mus musculus 118-127 7505613-7 1993 IL-1 beta-induced nitrite and PGE2 production is attenuated by the NOS inhibitor NG-monomethyl-L-arginine (NMMA), but NMMA has no inhibitory effect on the expression of either iCOX or iNOS as determined by immunoprecipitation. Nitrites 18-25 interleukin 1 beta Rattus norvegicus 0-9 7505613-8 1993 Actinomycin D prevents IL-1 beta-induced iCOX and iNOS expression and the production of both nitrite and PGE2 by islets, suggesting that mRNA transcription is required for IL-1 beta-induced expression of both iNOS and iCOX. Nitrites 93-100 interleukin 1 beta Rattus norvegicus 23-32 7505613-8 1993 Actinomycin D prevents IL-1 beta-induced iCOX and iNOS expression and the production of both nitrite and PGE2 by islets, suggesting that mRNA transcription is required for IL-1 beta-induced expression of both iNOS and iCOX. Nitrites 93-100 interleukin 1 beta Rattus norvegicus 172-181 7508326-11 1993 Dexamethasone (1 microM) abolished the increases in both nitrite and citrulline production induced by LPS alone but only partially reversed the combined effects of LPS and IFN-gamma. Nitrites 57-64 toll-like receptor 4 Mus musculus 102-105 8222083-9 1993 In arterialized blood (O2 saturation, 94% to 99%), incubated nitrite was semiquantitatively converted to nitrate and MetHb. Nitrites 61-68 hemoglobin subunit gamma 2 Homo sapiens 117-122 7504698-4 1993 We show that IL-1 beta treatment results in the formation of nitric oxide (as measured by accumulation of nitrite and cGMP) in both a time- and concentration-dependent manner that is prevented by aminoguanidine, a selective inhibitor of the inducible isoform of nitric oxide synthase. Nitrites 106-113 interleukin 1 beta Rattus norvegicus 13-22 7693710-2 1993 In cultured vascular smooth muscle cells, interferon gamma (IFN-gamma) induced the accumulation of nitrite, a stable metabolite of nitric oxide, in a dose- and time-dependent manner. Nitrites 99-106 interferon gamma Homo sapiens 42-69 8250925-0 1993 Nitrite production by stimulated human polymorphonuclear leukocytes supplemented with azide and catalase. Nitrites 0-7 catalase Homo sapiens 96-104 8250925-2 1993 We report here that nitrite production by phorbol myristate acetate (PMA)-stimulated human polymorphonuclear leukocytes (PMN) is considerably increased by the addition of azide and a further increase occurs when catalase also is added. Nitrites 20-27 catalase Homo sapiens 212-220 8250925-3 1993 Nitrite production by the PMN-PMA-azide-catalase system is unaffected by superoxide dismutase or monomethylarginine but is markedly reduced by the substitution of chronic granulomatous disease for normal neutrophils. Nitrites 0-7 catalase Homo sapiens 40-48 8238533-4 1993 The vascular effects of TNF were associated with 1) decreased lung effluent nitrite (NO2-, oxidation product of nitric oxide), 2) increased lung effluent superoxide (O2-), and 3) increased lung myeloperoxidase (MPO). Nitrites 76-83 tumor necrosis factor Cavia porcellus 24-27 8250925-5 1993 These findings suggest that nitrite production does not, in this instance, reflect nitric oxide synthase activity by human neutrophils but rather the catalase-catalyzed conversion of azide to nitrite in the presence of H2O2 generated by the stimulated PMN. Nitrites 192-199 catalase Homo sapiens 150-158 8225220-6 1993 High serum nitrite/nitrate levels were associated with high plasma renin activity, high aldosterone and antidiuretic hormone levels and low urinary excretion of sodium. Nitrites 11-18 renin Homo sapiens 67-72 7506668-1 1993 Treatment of mesangial cells with recombinant human interleukin 1 beta dose dependently increased nitrite formation due to the induction of a macrophage-type of nitric oxide (NO) synthase. Nitrites 98-105 interleukin 1 beta Homo sapiens 52-70 7506668-2 1993 Addition of cyclosporin A, cyclosporin G or cyclosporin H dose dependently inhibited interleukin 1 beta-induced nitrite generation. Nitrites 112-119 interleukin 1 beta Homo sapiens 85-103 7694796-2 1993 Nitrite production by peritoneal macrophages from mice receiving OK-432 treatment was significantly inhibited by phospholipase A2 inhibitors [dexamethasone and 4-bromophenacyl bromide (4-BPB)], lipoxygenase inhibitors [nordihydroguaiaretic acid (NDGA) and ketoconazole] and a glutathione S-transferase (leukotrienes LTA4-LTC4) inhibitor (ethacrynic acid). Nitrites 0-7 phospholipase A2, group IB, pancreas Mus musculus 113-129 7694796-2 1993 Nitrite production by peritoneal macrophages from mice receiving OK-432 treatment was significantly inhibited by phospholipase A2 inhibitors [dexamethasone and 4-bromophenacyl bromide (4-BPB)], lipoxygenase inhibitors [nordihydroguaiaretic acid (NDGA) and ketoconazole] and a glutathione S-transferase (leukotrienes LTA4-LTC4) inhibitor (ethacrynic acid). Nitrites 0-7 hematopoietic prostaglandin D synthase Mus musculus 276-301 8228620-2 1993 TGF-beta, added simultaneously with or up to 4 h before interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS), inhibited macrophage leishmanicidal activity, nitrite (NO2-) production, and secretion of prostaglandin E2. Nitrites 162-169 transforming growth factor, beta 1 Mus musculus 0-8 7509009-2 1993 The combination of interferon-gamma (100 U/ml) and tumor necrosis factor-alpha (5000 U/ml) evoked a time-dependent increase in nitric oxide synthase mRNA and nitrite/nitrate production, both of which were inhibited by dexamethasone. Nitrites 158-165 tumor necrosis factor Rattus norvegicus 19-78 7691579-6 1993 rIL-1 beta induced the expression of iNOS mRNA in RIN cells and a 12- to 13-fold increase in medium nitrite accumulation, the latter indicating NO production. Nitrites 100-107 interleukin 1 beta Rattus norvegicus 0-10 7691579-8 1993 Thus, 10 mM nicotinamide decreased rIL-1 beta-induced nitrite formation by 30%, 20 mM by 60%, and 50 mM by 90%. Nitrites 54-61 interleukin 1 beta Rattus norvegicus 35-45 7691579-11 1993 Dexamethasone also decreased rIL-1 beta-induced nitrite production without affecting iNOS mRNA expression. Nitrites 48-55 interleukin 1 beta Rattus norvegicus 29-39 7691748-7 1993 Nitrite production was induced in mock-infected or R. prowazekii-infected L929 cell cultures treated with IFN-gamma plus TNF-alpha, but not in mock-infected cultures that were untreated or treated with IFN-gamma or TNF-alpha alone. Nitrites 0-7 interferon gamma Mus musculus 106-115 8275053-9 1993 In the presence of 25 U/ml IFN-gamma MDHM-D gave a half maximal response at a dilution of 1/100,000, showing a parallel concentration dependency for nitrite production and cytocidal activity. Nitrites 149-156 interferon gamma Mus musculus 27-36 7691748-7 1993 Nitrite production was induced in mock-infected or R. prowazekii-infected L929 cell cultures treated with IFN-gamma plus TNF-alpha, but not in mock-infected cultures that were untreated or treated with IFN-gamma or TNF-alpha alone. Nitrites 0-7 tumor necrosis factor Mus musculus 121-130 7691748-7 1993 Nitrite production was induced in mock-infected or R. prowazekii-infected L929 cell cultures treated with IFN-gamma plus TNF-alpha, but not in mock-infected cultures that were untreated or treated with IFN-gamma or TNF-alpha alone. Nitrites 0-7 tumor necrosis factor Mus musculus 215-224 7691748-8 1993 Nitrite production was also not induced in untreated, R. prowazekii-infected cultures; however, in some instances, it was induced in infected cultures treated with IFN-gamma or TNF-alpha alone. Nitrites 0-7 interferon gamma Mus musculus 164-173 7691748-8 1993 Nitrite production was also not induced in untreated, R. prowazekii-infected cultures; however, in some instances, it was induced in infected cultures treated with IFN-gamma or TNF-alpha alone. Nitrites 0-7 tumor necrosis factor Mus musculus 177-186 7691748-9 1993 Nitrite production was blocked by NGMA or aminoguanidine, and these compounds markedly relieved the synergistic inhibitory effect of IFN-gamma plus TNF-alpha on the growth of strain 83-2P in L929 cells. Nitrites 0-7 interferon gamma Mus musculus 133-142 7691748-9 1993 Nitrite production was blocked by NGMA or aminoguanidine, and these compounds markedly relieved the synergistic inhibitory effect of IFN-gamma plus TNF-alpha on the growth of strain 83-2P in L929 cells. Nitrites 0-7 tumor necrosis factor Mus musculus 148-157 8373422-5 1993 Addition of 25 U/ml of interleukin-1 beta during the last 24 h of culture, led to a marked inhibition of glucose-stimulated insulin release and a 5-6 fold increase in nitrite production by rat insulinoma cells. Nitrites 167-174 interleukin 1 beta Rattus norvegicus 23-41 8397260-6 1993 Within minutes, IL-1 beta concentration-dependently (1 pg/ml-100 ng/ml) enhanced the release from activated PMC of nitric oxide, as measured by its ability to inhibit thrombin-induced platelet aggregation, and as confirmed with a biochemical assay for nitrite. Nitrites 252-259 interleukin 1 beta Rattus norvegicus 16-25 7690801-6 1993 IL-1 beta alone (40 to 1000 U/ml) induced formation of increasing amounts of nitrite with increasing concentrations of IL-1 beta present. Nitrites 77-84 interleukin 1 beta Rattus norvegicus 0-9 7690801-6 1993 IL-1 beta alone (40 to 1000 U/ml) induced formation of increasing amounts of nitrite with increasing concentrations of IL-1 beta present. Nitrites 77-84 interleukin 1 beta Rattus norvegicus 119-128 7690801-9 1993 Conversely, addition of high concentrations of TNF-alpha (> or = 500 U/ml) led to near maximal levels of nitrite formation even at lowest IL-1 beta concentrations (40 U/ml). Nitrites 108-115 tumor necrosis factor Rattus norvegicus 47-56 8134178-1 1993 In a rat model of fatal infection caused by Pseudomonas aeruginosa, the circulating level of nitrite/nitrate (NO2-/NO3-), a good indicator for nitric oxide production, was remarkably increased after elevation of circulatory tumor necrosis factor (TNF). Nitrites 93-100 tumor necrosis factor-like Rattus norvegicus 224-245 8134178-1 1993 In a rat model of fatal infection caused by Pseudomonas aeruginosa, the circulating level of nitrite/nitrate (NO2-/NO3-), a good indicator for nitric oxide production, was remarkably increased after elevation of circulatory tumor necrosis factor (TNF). Nitrites 93-100 tumor necrosis factor-like Rattus norvegicus 247-250 7688311-3 1993 Under these conditions and in contrast to its reported deactivating potential, IL-10 strongly enhanced NO synthesis measured as nitrite (NO2-) release (half maximal stimulation at approximately 10 U/ml). Nitrites 128-135 interleukin 10 Homo sapiens 79-84 8313743-2 1993 The results showed that the serum levels of AOA and SOD activity (nitrite unit per mg serum protein) were significantly higher than that of non-pregnant women (P < 0.01 and P < 0.005), and indicated that the serum condition of antioxidation was improved during the normal pregnancy. Nitrites 66-73 superoxide dismutase 1 Homo sapiens 52-55 8368322-4 1993 Nitrite/nitrate accumulation was maximal at 72 h, with most of the increase occurring from 48 to 72 h. Maximal nitrite/nitrate production was observed with triple combinations with the combination of LPS, IL-1, and TNF giving the highest concentration (137.4 +/- 2.8 microM). Nitrites 0-7 tumor necrosis factor-like Rattus norvegicus 215-218 8368322-4 1993 Nitrite/nitrate accumulation was maximal at 72 h, with most of the increase occurring from 48 to 72 h. Maximal nitrite/nitrate production was observed with triple combinations with the combination of LPS, IL-1, and TNF giving the highest concentration (137.4 +/- 2.8 microM). Nitrites 111-118 tumor necrosis factor-like Rattus norvegicus 215-218 7691770-5 1993 Furthermore, gamma IFN increased the activity of the inducible isoform of NO-synthase as well as the concentration of nitrite, one of the breakdown products of NO and the antiplatelet activity of astrocytoma cells. Nitrites 118-125 interferon alpha 1 Homo sapiens 19-22 7688473-2 1993 Induction of NO synthase (NOS) and COX (COX-2) in the mouse macrophage cell line RAW264.7 by Escherichia coli lipopolysaccharide (1 microgram/ml, 18 h) caused an increase in the release of nitrite (NO2-) and prostaglandin E2 (PGE2), products of NOS and COX, respectively. Nitrites 189-196 nitric oxide synthase 1, neuronal Mus musculus 13-24 7687436-2 1993 Preincubation of astrocytoma cells with gp 120 (10 pM, 100 and 500 nM) produced a significant, dose-dependent increase of nitrite levels in supernatant of pretreated cells which was higher when compared to untreated cells. Nitrites 122-129 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 40-46 7687436-4 1993 The rise of nitrite following pretreatment of astrocytoma cells with gp 120 was accompanied by an increase in NO synthase activity which was mainly Ca(++)-independent. Nitrites 12-19 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 69-75 7688473-2 1993 Induction of NO synthase (NOS) and COX (COX-2) in the mouse macrophage cell line RAW264.7 by Escherichia coli lipopolysaccharide (1 microgram/ml, 18 h) caused an increase in the release of nitrite (NO2-) and prostaglandin E2 (PGE2), products of NOS and COX, respectively. Nitrites 189-196 cytochrome c oxidase II, mitochondrial Mus musculus 40-45 8398001-1 1993 Cultured aortic smooth muscle cells from spontaneously hypertensive rats produce more nitrite than cells from Wistar-Kyoto rats in response to interleukin-1 beta. Nitrites 86-93 interleukin 1 beta Rattus norvegicus 143-161 8398001-11 1993 Interleukin-1 beta elicited greater concentration-dependent productions of cyclic GMP and nitrite in rings from spontaneously hypertensive than from Wistar-Kyoto rats, and these were inhibited by methylene blue and nitro-L-arginine, respectively. Nitrites 90-97 interleukin 1 beta Rattus norvegicus 0-18 8499487-4 1993 TNF also increased nitrite production in TNF-resistant U937A/R cells. Nitrites 19-26 tumor necrosis factor Homo sapiens 0-3 7686937-6 1993 Suppression of nitrite accumulation and iNOS enzyme activity by prior exposure of macrophages to LPS could be explained by their markedly decreased content of iNOS protein, as revealed by immunoblot with monospecific anti-iNOS IgG. Nitrites 15-22 nitric oxide synthase 2, inducible Mus musculus 159-163 7686937-6 1993 Suppression of nitrite accumulation and iNOS enzyme activity by prior exposure of macrophages to LPS could be explained by their markedly decreased content of iNOS protein, as revealed by immunoblot with monospecific anti-iNOS IgG. Nitrites 15-22 nitric oxide synthase 2, inducible Mus musculus 159-163 7689587-4 1993 In this report, we present evidence for the production of NO, as measured by the production of nitrite, in highly enriched human fetal astrocyte cultures stimulated with IL-1 beta. Nitrites 95-102 interleukin 1 beta Homo sapiens 170-179 7689587-6 1993 The IL-1 beta-induced nitrite production by astrocytes was markedly enhanced when cells were co-stimulated with IFN-gamma or TNF-alpha (IFN-gamma > TNF-alpha); LPS had no effect used as a single agent or in combination with other cytokines. Nitrites 22-29 interleukin 1 beta Homo sapiens 4-13 7689587-6 1993 The IL-1 beta-induced nitrite production by astrocytes was markedly enhanced when cells were co-stimulated with IFN-gamma or TNF-alpha (IFN-gamma > TNF-alpha); LPS had no effect used as a single agent or in combination with other cytokines. Nitrites 22-29 interferon gamma Homo sapiens 112-121 7689587-6 1993 The IL-1 beta-induced nitrite production by astrocytes was markedly enhanced when cells were co-stimulated with IFN-gamma or TNF-alpha (IFN-gamma > TNF-alpha); LPS had no effect used as a single agent or in combination with other cytokines. Nitrites 22-29 tumor necrosis factor Homo sapiens 125-134 7689587-6 1993 The IL-1 beta-induced nitrite production by astrocytes was markedly enhanced when cells were co-stimulated with IFN-gamma or TNF-alpha (IFN-gamma > TNF-alpha); LPS had no effect used as a single agent or in combination with other cytokines. Nitrites 22-29 interferon gamma Homo sapiens 136-145 7689587-6 1993 The IL-1 beta-induced nitrite production by astrocytes was markedly enhanced when cells were co-stimulated with IFN-gamma or TNF-alpha (IFN-gamma > TNF-alpha); LPS had no effect used as a single agent or in combination with other cytokines. Nitrites 22-29 tumor necrosis factor Homo sapiens 151-160 8357951-2 1993 Incubation of cultured rat or human aortic smooth muscle cells with interleukin-1 beta evoked a time- and concentration-dependent release of nitrite, an oxidation product of nitric oxide. Nitrites 141-148 interleukin 1 beta Homo sapiens 68-86 8357951-3 1993 The exposure of cells to interleukin-1 beta in combination with eicosapentaenoic acid caused a significantly larger production of nitrite than that evoked by the cytokine alone. Nitrites 130-137 interleukin 1 beta Homo sapiens 25-43 8357951-5 1993 The production of nitrite evoked by equieffective concentrations of interleukin-1 beta in the presence and absence of eicosapentaenoic acid were inhibited to a similar extent by nitro L-arginine (an inhibitor of nitric oxide synthase), transforming growth factor beta 1, platelet-derived growth factorAB and thrombin. Nitrites 18-25 interleukin 1 beta Homo sapiens 68-86 8357951-5 1993 The production of nitrite evoked by equieffective concentrations of interleukin-1 beta in the presence and absence of eicosapentaenoic acid were inhibited to a similar extent by nitro L-arginine (an inhibitor of nitric oxide synthase), transforming growth factor beta 1, platelet-derived growth factorAB and thrombin. Nitrites 18-25 transforming growth factor beta 1 Homo sapiens 236-269 8357951-5 1993 The production of nitrite evoked by equieffective concentrations of interleukin-1 beta in the presence and absence of eicosapentaenoic acid were inhibited to a similar extent by nitro L-arginine (an inhibitor of nitric oxide synthase), transforming growth factor beta 1, platelet-derived growth factorAB and thrombin. Nitrites 18-25 coagulation factor II, thrombin Homo sapiens 308-316 8499487-3 1993 TNF stimulated U937A nitrite production through a process that was abolished by the competitive inhibitors of nitric-oxide synthase N-omega-nitro-L-arginine methyl ester (NAME) and N-G-monomethyl-L-arginine (NMMA) without inhibition of TNF-induced cytotoxicity. Nitrites 21-28 tumor necrosis factor Homo sapiens 0-3 8499487-3 1993 TNF stimulated U937A nitrite production through a process that was abolished by the competitive inhibitors of nitric-oxide synthase N-omega-nitro-L-arginine methyl ester (NAME) and N-G-monomethyl-L-arginine (NMMA) without inhibition of TNF-induced cytotoxicity. Nitrites 21-28 tumor necrosis factor Homo sapiens 236-239 8499487-4 1993 TNF also increased nitrite production in TNF-resistant U937A/R cells. Nitrites 19-26 tumor necrosis factor Homo sapiens 41-44 8388915-5 1993 Lactoperoxidase complexes with nitrite ion and thiocyanate ion were characterized for comparison with the cyanide complex. Nitrites 31-38 lactoperoxidase Bos taurus 0-15 8321846-2 1993 The microparticle-bound mu IFN-gamma was found to activate cultured macrophages for nitrite production and had an anti-leishmanial effect in mice. Nitrites 84-91 interferon gamma Mus musculus 27-36 8321846-4 1993 Further, inducement of nitrite production in cultured macrophages by microparticle-bound mu IFN-gamma required intact cell membrane receptors. Nitrites 23-30 interferon gamma Mus musculus 92-101 7683432-3 1993 Transforming growth factor beta 1 slightly increases the production of nitrite, an oxidation product of NO, induced by LPS plus IFN-gamma, whereas acidic and basic FGFs markedly inhibit the nitrite release due to LPS/IFN-gamma in a concentration-dependent manner, and epidermal growth factor did not modify LPS/IFN-gamma-induced NOS activity. Nitrites 71-78 transforming growth factor beta 1 Bos taurus 0-33 7684333-7 1993 Pretreatment with 5 and 50 mM nitrite markedly depressed tumor necrosis factor (TNF)-alpha-dependent natural cytotoxicity of PMC for the tumor target WEHI-164. Nitrites 30-37 tumor necrosis factor Rattus norvegicus 57-90 7684333-8 1993 Thus, high concentrations of nitrite enhanced mast cell histamine release, but depressed TNF-alpha-dependent cytotoxicity. Nitrites 29-36 tumor necrosis factor Rattus norvegicus 89-98 7683432-3 1993 Transforming growth factor beta 1 slightly increases the production of nitrite, an oxidation product of NO, induced by LPS plus IFN-gamma, whereas acidic and basic FGFs markedly inhibit the nitrite release due to LPS/IFN-gamma in a concentration-dependent manner, and epidermal growth factor did not modify LPS/IFN-gamma-induced NOS activity. Nitrites 71-78 interferon gamma Bos taurus 128-137 7683432-3 1993 Transforming growth factor beta 1 slightly increases the production of nitrite, an oxidation product of NO, induced by LPS plus IFN-gamma, whereas acidic and basic FGFs markedly inhibit the nitrite release due to LPS/IFN-gamma in a concentration-dependent manner, and epidermal growth factor did not modify LPS/IFN-gamma-induced NOS activity. Nitrites 190-197 interferon gamma Bos taurus 217-226 8505145-5 1993 M-CSF or GM-CSF derived macrophages on treatment with IFN-gamma showed enhanced release of nitrite as compared to medium derived macrophages. Nitrites 91-98 colony stimulating factor 1 (macrophage) Mus musculus 0-5 8505145-5 1993 M-CSF or GM-CSF derived macrophages on treatment with IFN-gamma showed enhanced release of nitrite as compared to medium derived macrophages. Nitrites 91-98 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 9-15 8505145-5 1993 M-CSF or GM-CSF derived macrophages on treatment with IFN-gamma showed enhanced release of nitrite as compared to medium derived macrophages. Nitrites 91-98 interferon gamma Mus musculus 54-63 8505145-7 1993 Out of the different combinations tested, only IFN-gamma plus TNF-treated macrophages showed enhancement in nitrite production as compared to that of IFN-gamma alone. Nitrites 108-115 interferon gamma Mus musculus 47-56 8505145-7 1993 Out of the different combinations tested, only IFN-gamma plus TNF-treated macrophages showed enhancement in nitrite production as compared to that of IFN-gamma alone. Nitrites 108-115 tumor necrosis factor Mus musculus 62-65 7682068-3 1993 Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-). Nitrites 140-147 nitric oxide synthase 2 Rattus norvegicus 0-31 7682068-3 1993 Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-). Nitrites 140-147 nitric oxide synthase 2 Rattus norvegicus 33-37 7683959-1 1993 Inflammatory cytokines (interleukin 1 alpha, 1 beta and tumor necrosis factor-alpha) induce the formation of nitrite by C6 astrocytoma cells in a manner that was blocked by inhibitors of NO synthase such as NG-monomethylarginine. Nitrites 109-116 tumor necrosis factor Homo sapiens 24-83 7681667-3 1993 Inflammatory M phi treated with LPS or IFN-gamma alone produced low levels of nitrite and were not apoptotic, whereas a synergistic effect was observed, the combined treatment leading to high amounts of nitrite and to apoptosis. Nitrites 78-85 interferon gamma Mus musculus 39-48 7681667-3 1993 Inflammatory M phi treated with LPS or IFN-gamma alone produced low levels of nitrite and were not apoptotic, whereas a synergistic effect was observed, the combined treatment leading to high amounts of nitrite and to apoptosis. Nitrites 203-210 interferon gamma Mus musculus 39-48 8383325-5 1993 IL-1 beta and IFN-gamma are sufficient to induce nitric oxide formation by human islets, whereas TNF-alpha potentiates nitrite production. Nitrites 119-126 tumor necrosis factor Homo sapiens 97-106 7680009-3 1993 The induction of iNOS mRNA paralleled the cytokine-induced nitrite production. Nitrites 59-66 nitric oxide synthase 2 Homo sapiens 17-21 7680009-4 1993 Actinomycin D abolished the IFN gamma- and TNF alpha-induced increases in iNOS mRNA and nitrite production. Nitrites 88-95 interferon gamma Homo sapiens 28-37 7680009-4 1993 Actinomycin D abolished the IFN gamma- and TNF alpha-induced increases in iNOS mRNA and nitrite production. Nitrites 88-95 tumor necrosis factor Homo sapiens 43-52 7680009-5 1993 Cycloheximide, which abolished both the IFN gamma- and TNF alpha-induced increases in nitrite production, had no effect on the IFN gamma-induced increase in iNOS mRNA but markedly inhibited the TNF alpha-induced one. Nitrites 86-93 interferon gamma Homo sapiens 40-49 7680009-5 1993 Cycloheximide, which abolished both the IFN gamma- and TNF alpha-induced increases in nitrite production, had no effect on the IFN gamma-induced increase in iNOS mRNA but markedly inhibited the TNF alpha-induced one. Nitrites 86-93 tumor necrosis factor Homo sapiens 55-64 7680540-2 1993 IL-1 beta stimulated the release of nitrite (a stable oxidation product of nitric oxide) from cultured smooth muscle cells. Nitrites 36-43 interleukin 1 beta Rattus norvegicus 0-9 7680540-3 1993 Thrombin inhibited in a concentration-dependent manner the release of nitrite caused by IL-1 beta. Nitrites 70-77 coagulation factor II Rattus norvegicus 0-8 8447474-2 1993 Incubation of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite and nitrate in the culture media. Nitrites 98-105 interleukin 1 beta Homo sapiens 48-57 7680540-3 1993 Thrombin inhibited in a concentration-dependent manner the release of nitrite caused by IL-1 beta. Nitrites 70-77 interleukin 1 beta Rattus norvegicus 88-97 8447474-3 1993 Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta. Nitrites 159-166 plasminogen Homo sapiens 0-7 8447474-3 1993 Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta. Nitrites 159-166 interleukin 1 beta Homo sapiens 129-138 8447474-3 1993 Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta. Nitrites 277-284 plasminogen Homo sapiens 0-7 8447474-3 1993 Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta. Nitrites 277-284 interleukin 1 beta Homo sapiens 129-138 8447456-6 1993 After 24 h of incubation, TNF and LPS impaired the contractions to 5-hydroxytryptamine and increased the accumulation of nitrite, a stable degradation product of NO. Nitrites 121-128 tumor necrosis factor Homo sapiens 26-29 8440413-5 1993 The production of nitric oxide by islets under these pulse conditions is demonstrated by IL-1 beta-induced nitrite and electron paramagnetic resonance-detectable iron-nitrosyl complex formation, both of which are prevented by NMMA. Nitrites 107-114 interleukin 1 beta Rattus norvegicus 89-98 8480530-1 1993 Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines. Nitrites 149-156 interferon gamma Rattus norvegicus 56-72 8382836-8 1993 Increased luminal protein and intestinal MPO activity paralleled the changes in nitrite levels. Nitrites 80-87 myeloperoxidase Oryctolagus cuniculus 41-44 7679351-3 1993 Treatment with interleukin-1 beta (IL-1), a cytokine known to induce NO synthase, dose-dependently increased the basal level of intracellular cGMP with a concomitant increase of nitrite in the conditioned media. Nitrites 178-185 interleukin-1 beta Oryctolagus cuniculus 15-33 8480530-1 1993 Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines. Nitrites 149-156 interferon gamma Rattus norvegicus 177-193 8480530-1 1993 Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines. Nitrites 149-156 colony stimulating factor 2 Rattus norvegicus 219-267 8480530-3 1993 It was based on a simple synergism between interferon-gamma and muramyldipeptide and a priming effect of granulocyte-macrophage colony-stimulating factor for interferon-gamma-induced nitrite production. Nitrites 183-190 colony stimulating factor 2 Rattus norvegicus 105-153 8480530-3 1993 It was based on a simple synergism between interferon-gamma and muramyldipeptide and a priming effect of granulocyte-macrophage colony-stimulating factor for interferon-gamma-induced nitrite production. Nitrites 183-190 interferon gamma Rattus norvegicus 158-174 8437574-0 1993 nir1, a conditional-lethal mutation in barley causing a defect in nitrite reduction. Nitrites 66-73 Nir1 Hordeum vulgare 0-4 8317306-2 1993 Lipopolysaccharide (LPS) induced a dose- and time-dependent stimulation of nitrite production which was further increased in the presence of interferon-gamma (IFN-gamma). Nitrites 75-82 toll-like receptor 4 Mus musculus 20-23 8317306-2 1993 Lipopolysaccharide (LPS) induced a dose- and time-dependent stimulation of nitrite production which was further increased in the presence of interferon-gamma (IFN-gamma). Nitrites 75-82 interferon gamma Mus musculus 141-157 8317306-2 1993 Lipopolysaccharide (LPS) induced a dose- and time-dependent stimulation of nitrite production which was further increased in the presence of interferon-gamma (IFN-gamma). Nitrites 75-82 interferon gamma Mus musculus 159-168 8317306-5 1993 These findings indicate that activation of J774 cells with LPS produces an increase in both L-arginine transport and nitrite synthesis. Nitrites 117-124 toll-like receptor 4 Mus musculus 59-62 15091830-1 1993 A microbiological study conducted as a complement to kinetic studies of biological denitrification as a process for treating high-sodium-nitrite wastewaters generated from ship-boiler-tube cleaning is described. Nitrites 137-144 inositol polyphosphate-5-phosphatase D Homo sapiens 172-176 7684804-2 1993 The LPS-induced cyclic GMP and nitrite increase was enhanced by interferon-gamma and was prevented by L-NG-nitroarginine, dexamethasone and cycloheximide. Nitrites 31-38 interferon gamma Rattus norvegicus 64-80 1490962-7 1992 Lung effluent levels of nitrite, the oxidation product of NO, were reduced after treatment with either TNF-alpha or NG-monomethyl-L-arginine compared with U-46619 alone. Nitrites 24-31 tumor necrosis factor Cavia porcellus 103-112 1333417-0 1992 Interaction of human myeloperoxidase with nitrite. Nitrites 42-49 myeloperoxidase Homo sapiens 21-36 1333417-1 1992 EPR (electron paramagnetic resonance) and optical spectroscopy show that human neutrophil myeloperoxidase is converted from ferric high-spin to low-spin by the addition of nitrite. Nitrites 172-179 myeloperoxidase Homo sapiens 90-105 1280597-2 1992 In cultured rat lung fibroblasts the presence of L-arginine was necessary for the production of nitrite to be induced by rat recombinant interferon-gamma and synergistically enhanced by lipopolysaccharide and interleukin-1 beta. Nitrites 96-103 interferon gamma Rattus norvegicus 137-153 1280597-2 1992 In cultured rat lung fibroblasts the presence of L-arginine was necessary for the production of nitrite to be induced by rat recombinant interferon-gamma and synergistically enhanced by lipopolysaccharide and interleukin-1 beta. Nitrites 96-103 interleukin 1 beta Rattus norvegicus 209-227 1384580-3 1992 Exposure to tumor necrosis factor-alpha caused a modest (2x) increase in nitrite production. Nitrites 73-80 tumor necrosis factor Rattus norvegicus 12-39 1327576-4 1992 Elevation of nitrite levels in the conditioned medium of cultures exposed to interleukin-1 beta correlated with the inhibition of thymidine incorporation. Nitrites 13-20 interleukin 1 beta Homo sapiens 77-95 1327576-5 1992 Platelet-derived growth factor-AB and -BB inhibited the production of nitric oxide (measured as nitrite levels in conditioned medium) by cells treated simultaneously with interleukin-1 beta and growth factor. Nitrites 96-103 interleukin 1 beta Homo sapiens 171-207 1384478-1 1992 Incubation of rabbit articular chondrocytes with interleukin-1 beta caused time-dependent expression of NO synthase, determined as nitrite, after a lag period of 6h. Nitrites 131-138 interleukin-1 beta Oryctolagus cuniculus 49-67 1500182-0 1992 In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interleukin-1: possible roles in malaria. Nitrites 21-28 tumor necrosis factor Mus musculus 44-65 1384465-5 1992 cGMP formation and nitrite production induced by IL-1 beta pretreatment of islets are also blocked by the protein synthesis inhibitor, cycloheximide. Nitrites 19-26 interleukin 1 beta Homo sapiens 49-58 1422583-5 1992 Stimulation with increasing concentrations (0.01-10 micrograms ml-1) of bacterial lipopolysaccharide (LPS) caused the cells to produce increasing amounts of nitrite in the perfusion medium. Nitrites 157-164 toll-like receptor 4 Mus musculus 102-105 1422583-7 1992 The nitrite accumulation caused by 0.1 microgram ml-1 of LPS was augmented by priming the cells for 2 h with increasing amounts of interferon-gamma. Nitrites 4-11 toll-like receptor 4 Mus musculus 57-60 1422583-7 1992 The nitrite accumulation caused by 0.1 microgram ml-1 of LPS was augmented by priming the cells for 2 h with increasing amounts of interferon-gamma. Nitrites 4-11 interferon gamma Mus musculus 131-147 1505677-4 1992 The cells were then stimulated by interferon-gamma and tumor necrosis factor-alpha to increase their production of NO from 1.3 to 12.2 microM in 24 h, as measured by nitrite. Nitrites 166-173 interferon gamma Mus musculus 34-82 1497665-5 1992 In contrast, rat or mouse peritoneal macrophages produced nitrite concentrations of approximately 20-100 microM in response to lipopolysaccharide, Interferon-gamma, or both. Nitrites 58-65 interferon gamma Mus musculus 147-163 1522385-3 1992 We found that a cell line that was sensitive to TNF-mediated cytotoxicity produced NO in response to TNF as measured by the accumulation of nitrite in the supernatants of TNF-stimulated cells. Nitrites 140-147 tumor necrosis factor Mus musculus 48-51 1522385-3 1992 We found that a cell line that was sensitive to TNF-mediated cytotoxicity produced NO in response to TNF as measured by the accumulation of nitrite in the supernatants of TNF-stimulated cells. Nitrites 140-147 tumor necrosis factor Mus musculus 101-104 1522385-3 1992 We found that a cell line that was sensitive to TNF-mediated cytotoxicity produced NO in response to TNF as measured by the accumulation of nitrite in the supernatants of TNF-stimulated cells. Nitrites 140-147 tumor necrosis factor Mus musculus 101-104 1522385-6 1992 TNF-resistant cell lines produced less NO than a TNF-sensitive cell line, and the amount of nitrite produced correlated with the relative sensitivity of each cell line to TNF-mediated cytotoxicity. Nitrites 92-99 tumor necrosis factor Mus musculus 0-3 1324289-8 1992 However, GM-CSF augmented the LPS-induced production of nitrite and PGE2 by CSF-1-derived macrophages only. Nitrites 56-63 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 9-15 1324289-8 1992 However, GM-CSF augmented the LPS-induced production of nitrite and PGE2 by CSF-1-derived macrophages only. Nitrites 56-63 colony stimulating factor 1 (macrophage) Mus musculus 76-81 1282159-11 1992 Interleukin-1 beta induced a time- and concentration-dependent production of nitrite. Nitrites 77-84 interleukin 1 beta Homo sapiens 0-18 1282159-12 1992 Cycloheximide and nitro-L-arginine inhibited the relaxations and the production of nitrite evoked by interleukin-1 beta-treated cells. Nitrites 83-90 interleukin 1 beta Homo sapiens 101-119 1282159-14 1992 Transforming growth factor-beta 1 reduced the interleukin-1 beta-dependent generation of nitrite by cultured smooth muscle cells and relaxation of contracted bioassay tissues. Nitrites 89-96 transforming growth factor beta 1 Homo sapiens 0-33 1282159-14 1992 Transforming growth factor-beta 1 reduced the interleukin-1 beta-dependent generation of nitrite by cultured smooth muscle cells and relaxation of contracted bioassay tissues. Nitrites 89-96 interleukin 1 beta Homo sapiens 46-64 1638511-2 1992 Resident macrophages treated with interferon-gamma (IFN-gamma), lipopolysaccharide (LPS) plus muramyldipeptide (MDP) expressed a cytostatic activity against P815 tumor cells and released interleukin 6 (IL-6) and nitrite but produced neither IL-1 nor tumor necrosis factor (TNF). Nitrites 212-219 interferon gamma Mus musculus 34-50 1632773-2 1992 It has been demonstrated that activation of mouse brain endothelium by TNF-alpha and IFN-gamma led to accumulation of nitrite which is presumably formed by oxidation of nitric oxide. Nitrites 118-125 tumor necrosis factor Mus musculus 71-80 1632773-2 1992 It has been demonstrated that activation of mouse brain endothelium by TNF-alpha and IFN-gamma led to accumulation of nitrite which is presumably formed by oxidation of nitric oxide. Nitrites 118-125 interferon gamma Mus musculus 85-94 1638511-2 1992 Resident macrophages treated with interferon-gamma (IFN-gamma), lipopolysaccharide (LPS) plus muramyldipeptide (MDP) expressed a cytostatic activity against P815 tumor cells and released interleukin 6 (IL-6) and nitrite but produced neither IL-1 nor tumor necrosis factor (TNF). Nitrites 212-219 interferon gamma Mus musculus 52-61 1621630-4 1992 Nitrites are absorbed and form methemoglobin, which interferes with the oxygen-carrying capacity of hemoglobin. Nitrites 0-8 hemoglobin subunit gamma 2 Homo sapiens 31-44 1621837-9 1992 In cells cultured in multiwell plates, interleukin-1 beta evoked a time- and concentration-dependent accumulation of nitrite in the extracellular medium that was inhibited dose dependently by transforming growth factor-beta 1. Nitrites 117-124 interleukin 1 beta Homo sapiens 39-57 1521836-2 1992 Various amino acids at 100 mM, bovine serum albumin (BSA) and trypsinized casein at 100 mg/ml effectively decreased the nitrite level of 50 mM-nitrite solution at pH 3 and 37 degrees C. Most, but not all, amino acids can convert nitrite into nitrogen gas; Pro can be converted into non-mutagenic nitrosoproline, CySH to S-nitrosocysteine, Trp to weakly mutagenic nitrosotryptophan and Tyr to non-mutagenic diazotyrosine. Nitrites 120-127 albumin Homo sapiens 38-51 1521836-2 1992 Various amino acids at 100 mM, bovine serum albumin (BSA) and trypsinized casein at 100 mg/ml effectively decreased the nitrite level of 50 mM-nitrite solution at pH 3 and 37 degrees C. Most, but not all, amino acids can convert nitrite into nitrogen gas; Pro can be converted into non-mutagenic nitrosoproline, CySH to S-nitrosocysteine, Trp to weakly mutagenic nitrosotryptophan and Tyr to non-mutagenic diazotyrosine. Nitrites 143-150 albumin Homo sapiens 38-51 1521836-2 1992 Various amino acids at 100 mM, bovine serum albumin (BSA) and trypsinized casein at 100 mg/ml effectively decreased the nitrite level of 50 mM-nitrite solution at pH 3 and 37 degrees C. Most, but not all, amino acids can convert nitrite into nitrogen gas; Pro can be converted into non-mutagenic nitrosoproline, CySH to S-nitrosocysteine, Trp to weakly mutagenic nitrosotryptophan and Tyr to non-mutagenic diazotyrosine. Nitrites 143-150 albumin Homo sapiens 38-51 1385162-2 1992 TGF-beta 1, PDGFAB and PDGFBB but not PDGFAA inhibited in a concentration-dependent manner the production of nitrite, an oxidation product of nitric oxide, evoked by interleukin-1 beta. Nitrites 109-116 transforming growth factor beta 1 Homo sapiens 0-10 1385162-2 1992 TGF-beta 1, PDGFAB and PDGFBB but not PDGFAA inhibited in a concentration-dependent manner the production of nitrite, an oxidation product of nitric oxide, evoked by interleukin-1 beta. Nitrites 109-116 interleukin 1 beta Homo sapiens 166-184 1621837-9 1992 In cells cultured in multiwell plates, interleukin-1 beta evoked a time- and concentration-dependent accumulation of nitrite in the extracellular medium that was inhibited dose dependently by transforming growth factor-beta 1. Nitrites 117-124 transforming growth factor beta 1 Homo sapiens 192-225 1555245-2 1992 Upon incubation with bacterial lipopolysaccharide (LPS) or rat interferon-gamma (IFN-gamma), cells from the microglia-enriched fraction released measurable amounts of nitrite into the supernatant within 24-48 hr. Nitrites 167-174 interferon gamma Rattus norvegicus 63-79 1588047-6 1992 Similarly, IL-10, IL-4, or TGF-beta alone blocked the production of NO, and when used in combination these cytokines exhibited an enhanced inhibitory effect on nitrite production. Nitrites 160-167 interleukin 10 Mus musculus 11-16 1588047-6 1992 Similarly, IL-10, IL-4, or TGF-beta alone blocked the production of NO, and when used in combination these cytokines exhibited an enhanced inhibitory effect on nitrite production. Nitrites 160-167 interleukin 4 Mus musculus 18-22 1588047-6 1992 Similarly, IL-10, IL-4, or TGF-beta alone blocked the production of NO, and when used in combination these cytokines exhibited an enhanced inhibitory effect on nitrite production. Nitrites 160-167 transforming growth factor, beta 1 Mus musculus 27-35 1599394-2 1992 Bacterial lipopolysaccharide (LPS) induced a dose- and time-dependent stimulation of nitrite production, which was further increased in the presence of interferon-gamma. Nitrites 85-92 interferon gamma Mus musculus 152-168 1567195-7 1992 These data support the view that ergothioneine and urate delay oxyhemoglobin oxidation by nitrite upon the temporary removal of the propagating species, i.e., nitrogen dioxide and, secondarily, ferrylhemoglobin, and within a mechanism encompassing alterations of the nitrite in equilibrium with nitrogen dioxide and ferrylhemoglobin in equilibrium with methemoglobin redox transitions. Nitrites 90-97 hemoglobin subunit gamma 2 Homo sapiens 353-366 1460412-4 1992 Nitrite induced methemoglobin can be extremely dangerous and even lethal. Nitrites 0-7 hemoglobin subunit gamma 2 Homo sapiens 16-29 1555245-2 1992 Upon incubation with bacterial lipopolysaccharide (LPS) or rat interferon-gamma (IFN-gamma), cells from the microglia-enriched fraction released measurable amounts of nitrite into the supernatant within 24-48 hr. Nitrites 167-174 interferon gamma Rattus norvegicus 81-90 1555245-3 1992 The production of nitrite was dependent on the cell number and the dose of IFN-gamma and LPS. Nitrites 18-25 interferon gamma Rattus norvegicus 75-84 1314664-7 1992 Second, when the illuminated reaction mixture was supplied with 0.2 mM to 1 mM nitrite, a concentration range of nitrite which quenches the tryptophan phosphorescence but not the fluorescence, the amount of reduced cytochrome c on illumination markedly decreased. Nitrites 79-86 cytochrome c, somatic Homo sapiens 215-227 1314664-7 1992 Second, when the illuminated reaction mixture was supplied with 0.2 mM to 1 mM nitrite, a concentration range of nitrite which quenches the tryptophan phosphorescence but not the fluorescence, the amount of reduced cytochrome c on illumination markedly decreased. Nitrites 113-120 cytochrome c, somatic Homo sapiens 215-227 1314741-0 1992 Curcumin inhibits nitrite-induced methemoglobin formation. Nitrites 18-25 hemoglobin subunit gamma 2 Homo sapiens 34-47 1314486-3 1992 A combination of lipopolysaccharide (LPS), interferon-gamma, tumor necrosis factor, and interleukin-1 stimulates the biosynthesis of large quantities of nitrite and nitrate (NO2- + NO3-). Nitrites 153-160 interferon gamma Rattus norvegicus 43-59 1373865-1 1992 The fried food mutagens IQ, MeIQ, Glu-P-1 and Trp-P-2 were treated with nitrite at pH 3.0 for 1 h at 37 degrees C. The resulting reaction mixtures were tested for mutagenicity towards Salmonella typhimurium TA97, TA98, TA100 and TA1535. Nitrites 72-79 polycystin 2, transient receptor potential cation channel Rattus norvegicus 46-53 1372867-1 1992 Activation of J774-macrophages with lipopolysaccharide (LPS) or LPS and recombinant interferon-gamma (IFN-gamma) induced nitric oxide (NO) synthase activity, as measured by the production of nitrite and citrulline. Nitrites 191-198 interferon gamma Homo sapiens 84-111 1606187-4 1992 Bradykinin had a stimulating effect on human and bovine endothelial cells and led to a threefold increase of nitrite/nitrate in endothelial cell column perfusates compared to those of unstimulated cells. Nitrites 109-116 kininogen 1 Homo sapiens 0-10 1540213-10 1992 Pretreatment with phorone, a glutathione S-transferase substrate, depleted cellular glutathione and decreased nitrite production from GTN. Nitrites 110-117 glutathione S-transferase kappa 1 Homo sapiens 29-54 1606639-2 1992 We showed here that nitrite influenced cell growth and antibody production in mouse lipopolysaccharide (LPS)-stimulated splenic B cells and B cell hybridomas. Nitrites 20-27 toll-like receptor 4 Mus musculus 104-107 1606639-3 1992 The addition of 10(-7) and 10(-6) M nitrite enhanced deoxyribonucleic acid (DNA) synthesis of LPS-stimulated splenic B cells. Nitrites 36-43 toll-like receptor 4 Mus musculus 94-97 1606639-4 1992 However, DNA synthesis and antibody production in the case of total spleen cells stimulated with LPS were suppressed by nitrite in a dose dependent-manner. Nitrites 120-127 toll-like receptor 4 Mus musculus 97-100 16668656-0 1992 Nitrate Reductase Regulates Expression of Nitrite Uptake and Nitrite Reductase Activities in Chlamydomonas reinhardtii. Nitrites 42-49 uncharacterized protein Chlamydomonas reinhardtii 0-17 1731791-2 1992 It was found that both IL-1 beta and nitroprusside increased islet nitrite production. Nitrites 67-74 interleukin 1 beta Mus musculus 23-32 16668656-3 1992 In mutants defective at the regulatory locus for nitrate reductase (nit-2), very low levels of nitrite uptake and nitrite reductase activities were expressed even in the presence of nitrate or nitrite. Nitrites 95-102 uncharacterized protein Chlamydomonas reinhardtii 49-66 16668656-3 1992 In mutants defective at the regulatory locus for nitrate reductase (nit-2), very low levels of nitrite uptake and nitrite reductase activities were expressed even in the presence of nitrate or nitrite. Nitrites 95-102 uncharacterized protein Chlamydomonas reinhardtii 68-73 16668656-3 1992 In mutants defective at the regulatory locus for nitrate reductase (nit-2), very low levels of nitrite uptake and nitrite reductase activities were expressed even in the presence of nitrate or nitrite. Nitrites 114-121 uncharacterized protein Chlamydomonas reinhardtii 49-66 16668656-3 1992 In mutants defective at the regulatory locus for nitrate reductase (nit-2), very low levels of nitrite uptake and nitrite reductase activities were expressed even in the presence of nitrate or nitrite. Nitrites 114-121 uncharacterized protein Chlamydomonas reinhardtii 68-73 16668656-4 1992 Both restoration of nitrate reductase activity in mutants defective at nit-1, nit-3, and nit-4 by isolating diploid strains among them and transformation of a structural mutant upon integration of the wild-type nit-1 gene gave rise to the wild-type expression pattern for nitrite uptake and nitrite reductase activities. Nitrites 272-279 uncharacterized protein Chlamydomonas reinhardtii 20-37 16668656-4 1992 Both restoration of nitrate reductase activity in mutants defective at nit-1, nit-3, and nit-4 by isolating diploid strains among them and transformation of a structural mutant upon integration of the wild-type nit-1 gene gave rise to the wild-type expression pattern for nitrite uptake and nitrite reductase activities. Nitrites 272-279 uncharacterized protein Chlamydomonas reinhardtii 211-216 16668656-5 1992 Conversely, inactivation of nitrate reductase by tungstate treatment in nitrate, nitrite, or nitrogen-free media made wild-type cells respond like nitrate reductase-deficient mutants with respect to the expression of nitrite uptake and nitrite reductase activities. Nitrites 81-88 uncharacterized protein Chlamydomonas reinhardtii 28-45 16668656-5 1992 Conversely, inactivation of nitrate reductase by tungstate treatment in nitrate, nitrite, or nitrogen-free media made wild-type cells respond like nitrate reductase-deficient mutants with respect to the expression of nitrite uptake and nitrite reductase activities. Nitrites 217-224 uncharacterized protein Chlamydomonas reinhardtii 28-45 16668656-6 1992 Our results indicate that nit-2 is a regulatory locus for both the nitrite uptake system and nitrite reductase, and that the nitrate reductase enzyme plays an important role in the regulation of the expression of both enzyme activities. Nitrites 67-74 uncharacterized protein Chlamydomonas reinhardtii 26-31 1731791-6 1992 The islets responded to IL-1 beta with an increased nitrite production and a decreased activity of aconitase, whereas the islet glucose oxidation rates were not decreased. Nitrites 52-59 interleukin 1 beta Mus musculus 24-33 1330790-5 1992 The measurement of nitrite production by mos exposed to the immunomodulators with or without treatment with 10 U/ml of IFN-gamma was found to be a highly convenient procedure, which correlated well with functional assays. Nitrites 19-26 interferon gamma Mus musculus 119-128 1282951-2 1992 The release of nitrite, an oxidation product of NO, from interleukin-1 beta-activated SMCs was inhibited by thrombin. Nitrites 15-22 interleukin 1 beta Rattus norvegicus 57-75 1282951-2 1992 The release of nitrite, an oxidation product of NO, from interleukin-1 beta-activated SMCs was inhibited by thrombin. Nitrites 15-22 coagulation factor II Rattus norvegicus 108-116 1740646-4 1992 In contrast, CSF-1-derived BMDMs produced nitrite in response to lipopolysaccharide (LPS) alone, whereas GM-CSF-derived BMDMs required interferon gamma plus LPS treatment. Nitrites 42-49 colony stimulating factor 1 Homo sapiens 13-18 1661096-8 1991 Treatment of smooth muscle cells with IL-1 beta also resulted in an eightfold increase in nitrite production, which was blocked when the cells were incubated with L-NNA. Nitrites 90-97 interleukin 1 beta Rattus norvegicus 38-47 1661096-9 1991 The addition of cycloheximide to smooth muscle cells during their incubation with IL-1 beta completely inhibited smooth muscle cell nitrite production, the effects of the smooth muscle cells on platelet cGMP levels, and platelet responses to thrombin. Nitrites 132-139 interleukin 1 beta Rattus norvegicus 82-91 1720090-7 1991 Both Meth-arg and N alpha-p-tosyl-L-lysine chloromethyl ketone (0.1 mM), a protease inhibitor, could completely counteract the IL-1 beta-induced increases in nitrite production and inhibition of aconitase activity and glucose oxidation rates. Nitrites 158-165 interleukin 1 beta Rattus norvegicus 127-136 1720090-9 1991 The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the IL-1 beta-induced rise in nitrite production and the IL-1 beta-induced inhibition of aconitase activity and insulin release. Nitrites 113-120 interleukin 1 beta Rattus norvegicus 45-54 1720090-9 1991 The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the IL-1 beta-induced rise in nitrite production and the IL-1 beta-induced inhibition of aconitase activity and insulin release. Nitrites 113-120 interleukin 1 beta Rattus norvegicus 87-96 1720090-9 1991 The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the IL-1 beta-induced rise in nitrite production and the IL-1 beta-induced inhibition of aconitase activity and insulin release. Nitrites 113-120 interleukin 1 beta Rattus norvegicus 87-96 1658153-5 1991 A combination of IL-1, LPS, and TNF-alpha was shown to induce maximal production of 355 +/- 51 nmol/10(6) cells/72 h of nitrite (NO2-), which was measured as a stable end-product of .N = O generation. Nitrites 120-127 interleukin 1 alpha Homo sapiens 17-21 1658153-5 1991 A combination of IL-1, LPS, and TNF-alpha was shown to induce maximal production of 355 +/- 51 nmol/10(6) cells/72 h of nitrite (NO2-), which was measured as a stable end-product of .N = O generation. Nitrites 120-127 tumor necrosis factor Homo sapiens 32-41 1804302-13 1991 In case of macrophages cultured with rIFN-gamma or rIL-4, the concentration of nitrite was related with cytotoxicity of macrophages against T. vaginalis, but the cytotoxicity of macrophages cultured with rIL-2 and rIFN-gamma was decreased in spite of its high production of nitrite. Nitrites 79-86 interferon gamma Rattus norvegicus 37-47 1804302-13 1991 In case of macrophages cultured with rIFN-gamma or rIL-4, the concentration of nitrite was related with cytotoxicity of macrophages against T. vaginalis, but the cytotoxicity of macrophages cultured with rIL-2 and rIFN-gamma was decreased in spite of its high production of nitrite. Nitrites 79-86 interleukin 4 Rattus norvegicus 51-56 1804302-13 1991 In case of macrophages cultured with rIFN-gamma or rIL-4, the concentration of nitrite was related with cytotoxicity of macrophages against T. vaginalis, but the cytotoxicity of macrophages cultured with rIL-2 and rIFN-gamma was decreased in spite of its high production of nitrite. Nitrites 79-86 interleukin 2 Rattus norvegicus 204-209 1804302-13 1991 In case of macrophages cultured with rIFN-gamma or rIL-4, the concentration of nitrite was related with cytotoxicity of macrophages against T. vaginalis, but the cytotoxicity of macrophages cultured with rIL-2 and rIFN-gamma was decreased in spite of its high production of nitrite. Nitrites 79-86 interferon gamma Rattus norvegicus 214-224 1804302-13 1991 In case of macrophages cultured with rIFN-gamma or rIL-4, the concentration of nitrite was related with cytotoxicity of macrophages against T. vaginalis, but the cytotoxicity of macrophages cultured with rIL-2 and rIFN-gamma was decreased in spite of its high production of nitrite. Nitrites 274-281 interferon gamma Rattus norvegicus 37-47 1804302-13 1991 In case of macrophages cultured with rIFN-gamma or rIL-4, the concentration of nitrite was related with cytotoxicity of macrophages against T. vaginalis, but the cytotoxicity of macrophages cultured with rIL-2 and rIFN-gamma was decreased in spite of its high production of nitrite. Nitrites 274-281 interleukin 4 Rattus norvegicus 51-56 1804302-14 1991 From the results obtained, it is assumed that rIL-2 and rIFN-gamma enhance the cytotoxicity of macrophages while rIL-4 inhibits the cytotoxicity against T. vaginalis, and that the production of nitrite does not relate with the cytotoxicity of macrophages, but nitric oxide may play a role as an inhibitory factor on the proliferation of T. vaginalis. Nitrites 194-201 interleukin 2 Rattus norvegicus 46-51 1804302-14 1991 From the results obtained, it is assumed that rIL-2 and rIFN-gamma enhance the cytotoxicity of macrophages while rIL-4 inhibits the cytotoxicity against T. vaginalis, and that the production of nitrite does not relate with the cytotoxicity of macrophages, but nitric oxide may play a role as an inhibitory factor on the proliferation of T. vaginalis. Nitrites 194-201 interferon gamma Rattus norvegicus 56-66 1716889-0 1991 Inhibitors of poly (ADP-ribose) polymerase suppress lipopolysaccharide-induced nitrite formation in macrophages. Nitrites 79-86 poly(ADP-ribose) polymerase 1 Homo sapiens 14-42 1915557-1 1991 Previously, we reported that exposure of bone marrow-derived macrophages (M phi) to a phagocytic stimulus in the simultaneous presence of interferon-gamma (IFN-gamma) induced these cells to generate nitrite (NO2-). Nitrites 199-206 interferon gamma Rattus norvegicus 156-165 1860156-8 1991 In aqueous buffer, pH 2.5, and in the presence of 1 mM AA, 50 microM nitrite was consumed with a t1/2 of 50 min only if molecular oxygen had first been removed from the system. Nitrites 69-76 interleukin 1 receptor like 1 Homo sapiens 97-107 1712676-11 1991 The activity for forming L-citrulline and nitrite/nitrate from L-arginine was markedly induced by treatment with either LPS alone or LPS + IFN-gamma but not with IFN-gamma. Nitrites 42-49 interferon gamma Mus musculus 139-148 1782986-1 1991 Rat alveolar and pleural macrophages incubated with lipopolysaccharide, opsonized zymosan or recombinant interferon-gamma, but not with recombinant tumor necrosis factor-alpha, produced nitrite dose and time dependently. Nitrites 186-193 interferon gamma Rattus norvegicus 105-121 1902865-5 1991 The LPS inhibitor polymyxin B and TNF alpha antibody produced a modest decrease in nitrite production, while IFN gamma antibody markedly inhibited both nitrite production and cytostasis. Nitrites 83-90 tumor necrosis factor Mus musculus 34-43 1902865-5 1991 The LPS inhibitor polymyxin B and TNF alpha antibody produced a modest decrease in nitrite production, while IFN gamma antibody markedly inhibited both nitrite production and cytostasis. Nitrites 152-159 interferon gamma Mus musculus 109-118 1902865-6 1991 Simultaneous treatment with polymyxin B, TNF alpha antibody, and IFN gamma antibody reduced EMT-6 cell nitrite production by 81%, and cytostasis by 74%. Nitrites 103-110 tumor necrosis factor Mus musculus 41-50 1902865-6 1991 Simultaneous treatment with polymyxin B, TNF alpha antibody, and IFN gamma antibody reduced EMT-6 cell nitrite production by 81%, and cytostasis by 74%. Nitrites 103-110 interferon gamma Mus musculus 65-74 2040662-0 1991 Effect of recombinant human interleukin-6 on nitrite production of mouse myeloid leukemia cells. Nitrites 45-52 interleukin 6 Homo sapiens 28-41 2043680-6 1991 Nitrite uptake expression was strongly inhibited by the presence of the glutamine synthetase inhibitor L-methionine-D,L-sulfoximine under either derepression or induction conditions, whereas that of nitrite reductase was not affected under the same conditions. Nitrites 0-7 uncharacterized protein Chlamydomonas reinhardtii 72-92 2043680-6 1991 Nitrite uptake expression was strongly inhibited by the presence of the glutamine synthetase inhibitor L-methionine-D,L-sulfoximine under either derepression or induction conditions, whereas that of nitrite reductase was not affected under the same conditions. Nitrites 0-7 uncharacterized protein Chlamydomonas reinhardtii 199-216 2029741-4 1991 Sodium azide, an inhibitor of myeloperoxidase and catalase, reduced the nitrite-stimulated metabolism of BP-7,8-diol in PMA-activated leukocytes. Nitrites 72-79 myeloperoxidase Homo sapiens 30-45 2029741-4 1991 Sodium azide, an inhibitor of myeloperoxidase and catalase, reduced the nitrite-stimulated metabolism of BP-7,8-diol in PMA-activated leukocytes. Nitrites 72-79 catalase Homo sapiens 50-58 2040662-1 1991 The effect of recombinant human interleukin-6 (rhIL-6) on induction of nitrite (NO(-2)) production was investigated in a mouse myeloid leukemia cell line (M1) and a subclone (Mm1). Nitrites 71-78 interleukin 6 Homo sapiens 32-45 1846742-2 1991 Reduction of nitrate, or nitrite, to N2O under aerobic conditions involves NO as an intermediate, as judged by trapping experiments with the ferric form of extracellular horse heart cytochrome c and the demonstration that the cells possess a nitric oxide reductase activity. Nitrites 25-32 cytochrome c, somatic Equus caballus 182-194 1706941-5 1991 Furthermore, nitrite production in these cells significantly decreased by addition of anti-interferon gamma antibody (62.9% inhibition). Nitrites 13-20 interferon gamma Mus musculus 91-107 1706941-6 1991 These data indicate that nitrite production in antigen-immunized spleen cells is affected with the immunogenicity of an antigen and regulated by T cells, especially interferon (IFN) gamma. Nitrites 25-32 interferon gamma Mus musculus 165-187 1855835-5 1991 In the study reported here, we evaluate the nitrite trapping capacity of thioproline in a male nonsmoking volunteer ingesting NO3- and eating a controlled diet. Nitrites 44-51 NBL1, DAN family BMP antagonist Homo sapiens 126-129 2060036-8 1991 Metabolism of either species to nitrite was dependent on the presence in the incubate of viable microsomes and of NADPH, and it was inhibited in the presence of carbon monoxide or the cytochrome P-450 inhibitor SKF525A. Nitrites 32-39 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 184-200 1713193-0 1991 Macrophages produce nitrite, nitrate and nitrosamines after addition of catalase. Nitrites 20-27 catalase Mus musculus 72-80 1713193-1 1991 Mouse macrophages produced nitrite and N-nitrosomorpholine after incubation with catalase. Nitrites 27-34 catalase Mus musculus 81-89 1855835-7 1991 We estimated the effective amount of nitrite, defined as the actual amount of nitrite participating in nitrosation in the stomach, to be 0.3% of the NO3- ingested. Nitrites 37-44 NBL1, DAN family BMP antagonist Homo sapiens 149-152 1855835-8 1991 Thus, the effective amount of NO2- for 6 mmol NO3- ingested was calculated to be 18 mumol, and 33% of this nitrite was trapped by ingestion of 0.45 mmol thioproline. Nitrites 107-114 NBL1, DAN family BMP antagonist Homo sapiens 46-49 2265709-3 1990 Tissue culture medium nitrite levels were raised in islets treated with IL-1 beta or TNF-alpha (48 h). Nitrites 22-29 interleukin 1 beta Rattus norvegicus 72-81 2265709-3 1990 Tissue culture medium nitrite levels were raised in islets treated with IL-1 beta or TNF-alpha (48 h). Nitrites 22-29 tumor necrosis factor Rattus norvegicus 85-94 2124251-1 1990 The present study demonstrates that murine dermal fibroblasts produce nitrite (NO2-) and nitrate (NO3-) upon treatment with interferon gamma (IFN-gamma). Nitrites 70-77 interferon gamma Mus musculus 124-151 2117605-1 1990 The murine adenocarcinoma cell line TA 3 synthesized nitrite from L-arginine upon stimulation with gamma-interferon (IFN-gamma) associated with tumor necrosis factor (TNF), and/or bacterial lipopolysaccharide (LPS), but not with IFN-gamma, TNF, or LPS added separately. Nitrites 53-60 interferon gamma Mus musculus 99-115 2124106-1 1990 Treatment of EMT 6 mammary adenocarcinoma cells with Interferon-gamma (IFN-gamma, 10 U.ml-1) plus endotoxin lipopolysaccharide (LPS, 100 ng.ml-1) induces concomitantly a growth arrest and production of citrulline and nitrite from L-arginine. Nitrites 217-224 interferon gamma Mus musculus 53-69 2124106-1 1990 Treatment of EMT 6 mammary adenocarcinoma cells with Interferon-gamma (IFN-gamma, 10 U.ml-1) plus endotoxin lipopolysaccharide (LPS, 100 ng.ml-1) induces concomitantly a growth arrest and production of citrulline and nitrite from L-arginine. Nitrites 217-224 interferon gamma Mus musculus 71-80 2276325-1 1990 Manganese-containing superoxide dismutase (Mn-SOD) activity in lung cancer tissue from 5 lung cancer patients was measured by nitrite formation method, and lipid peroxide (LPO) was measured spectrophotometrically by thiobarbituric acid reaction. Nitrites 126-133 superoxide dismutase 2 Homo sapiens 0-41 2276325-1 1990 Manganese-containing superoxide dismutase (Mn-SOD) activity in lung cancer tissue from 5 lung cancer patients was measured by nitrite formation method, and lipid peroxide (LPO) was measured spectrophotometrically by thiobarbituric acid reaction. Nitrites 126-133 superoxide dismutase 2 Homo sapiens 43-49 2117605-1 1990 The murine adenocarcinoma cell line TA 3 synthesized nitrite from L-arginine upon stimulation with gamma-interferon (IFN-gamma) associated with tumor necrosis factor (TNF), and/or bacterial lipopolysaccharide (LPS), but not with IFN-gamma, TNF, or LPS added separately. Nitrites 53-60 interferon gamma Mus musculus 117-126 2117605-1 1990 The murine adenocarcinoma cell line TA 3 synthesized nitrite from L-arginine upon stimulation with gamma-interferon (IFN-gamma) associated with tumor necrosis factor (TNF), and/or bacterial lipopolysaccharide (LPS), but not with IFN-gamma, TNF, or LPS added separately. Nitrites 53-60 tumor necrosis factor Mus musculus 144-165 2115549-3 1990 These inhibitors partially blocked induction of nitrite release in macrophages activated with the combination of IFN-gamma plus TNF-alpha, but were incapable of inhibiting when macrophages were activated by the combination of IFN-gamma plus LPS. Nitrites 48-55 interferon gamma Mus musculus 113-122 2115549-4 1990 MDF and TGF-beta 1, -beta 2, and -beta 3 inhibited IFN-gamma-induced nitrite release only if present during the induction phase; once IFN-gamma-nitrite release had commenced, addition of the same cytokines was no longer inhibitory. Nitrites 69-76 SCY1-like 1 (S. cerevisiae) Mus musculus 0-3 2115549-4 1990 MDF and TGF-beta 1, -beta 2, and -beta 3 inhibited IFN-gamma-induced nitrite release only if present during the induction phase; once IFN-gamma-nitrite release had commenced, addition of the same cytokines was no longer inhibitory. Nitrites 69-76 transforming growth factor, beta 1 Mus musculus 8-40 2115549-4 1990 MDF and TGF-beta 1, -beta 2, and -beta 3 inhibited IFN-gamma-induced nitrite release only if present during the induction phase; once IFN-gamma-nitrite release had commenced, addition of the same cytokines was no longer inhibitory. Nitrites 69-76 interferon gamma Mus musculus 51-60 2115549-4 1990 MDF and TGF-beta 1, -beta 2, and -beta 3 inhibited IFN-gamma-induced nitrite release only if present during the induction phase; once IFN-gamma-nitrite release had commenced, addition of the same cytokines was no longer inhibitory. Nitrites 144-151 SCY1-like 1 (S. cerevisiae) Mus musculus 0-3 2115549-4 1990 MDF and TGF-beta 1, -beta 2, and -beta 3 inhibited IFN-gamma-induced nitrite release only if present during the induction phase; once IFN-gamma-nitrite release had commenced, addition of the same cytokines was no longer inhibitory. Nitrites 144-151 interferon gamma Mus musculus 134-143 2115549-3 1990 These inhibitors partially blocked induction of nitrite release in macrophages activated with the combination of IFN-gamma plus TNF-alpha, but were incapable of inhibiting when macrophages were activated by the combination of IFN-gamma plus LPS. Nitrites 48-55 tumor necrosis factor Mus musculus 128-137 2109093-5 1990 Interferon gamma, in combination with tumor necrosis factor, interleukin-1 (IL-1), or endotoxin, induced murine brain endothelial cells to secrete nitrites (20-45 microM within 48 hr), which are breakdown products of nitric oxide. Nitrites 147-155 interferon gamma Mus musculus 0-16 2109093-5 1990 Interferon gamma, in combination with tumor necrosis factor, interleukin-1 (IL-1), or endotoxin, induced murine brain endothelial cells to secrete nitrites (20-45 microM within 48 hr), which are breakdown products of nitric oxide. Nitrites 147-155 tumor necrosis factor Homo sapiens 38-59 33944612-1 2021 Aim: We examined the relationships between visfatin/NAMPT and nitrite concentrations (a marker of nitric oxide [NO] formation) or sFlt-1 levels in 205 patients with preeclampsia (PE) responsive or nonresponsive to antihypertensive therapy, and whether NAMPT SNPs rs1319501 and rs3801266 affect nitrite concentrations in PE and 206 healthy pregnant women. Nitrites 62-69 nicotinamide phosphoribosyltransferase Homo sapiens 43-51 2109093-5 1990 Interferon gamma, in combination with tumor necrosis factor, interleukin-1 (IL-1), or endotoxin, induced murine brain endothelial cells to secrete nitrites (20-45 microM within 48 hr), which are breakdown products of nitric oxide. Nitrites 147-155 interleukin 1 alpha Homo sapiens 61-74 2093192-8 1990 These results indicated that the formation of methemoglobin from hemoglobin with nitrogen monoxide, nitrogen dioxide and nitrite ion appears to be controlled by the blood catalase. Nitrites 121-128 hemoglobin subunit gamma 2 Homo sapiens 46-59 9330595-3 1997 IL-1 beta significantly increased the production of NO (assessed by nitrite measured in the culture medium) and PGE2 in cultures of ovarian dispersates but had no effect on cultures of GL cells in which NO production was typically very low and PGE2 production was undetectable. Nitrites 68-75 interleukin 1 beta Rattus norvegicus 0-9 2154196-5 1990 Furthermore, we detected a virtually identical signal in macrophages non stimulated by IFN-gamma, following exposure to nitric oxide (after addition of an excess of nitrite in the presence of ascorbate). Nitrites 165-172 interferon gamma Mus musculus 87-96 33944612-3 2021 Results: In nonresponsive PE patients, visfatin/NAMPT levels were inversely related to nitrite concentrations and positively related to sFlt-1 levels. Nitrites 87-94 nicotinamide phosphoribosyltransferase Homo sapiens 39-47 33944612-3 2021 Results: In nonresponsive PE patients, visfatin/NAMPT levels were inversely related to nitrite concentrations and positively related to sFlt-1 levels. Nitrites 87-94 nicotinamide phosphoribosyltransferase Homo sapiens 48-53 33944612-4 2021 NAMPT SNP rs1319501 affected nitrite concentrations in nonresponsive PE patients and was tightly linked with NAMPT functional SNPs in Europeans. Nitrites 29-36 nicotinamide phosphoribosyltransferase Homo sapiens 0-5 34953459-3 2022 The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds. Nitrites 292-299 mitochondrially encoded cytochrome c oxidase II Homo sapiens 48-54 33808880-4 2021 We studied the PPARbeta/delta-regulation of lipopolysaccharide (LPS) induced inflammation (indicated by release of nitrite and IL-6) of rat pulmonary artery, using different combinations of agonists (GW0742 or L-165402) and antagonists (GSK3787 or GSK0660). Nitrites 115-122 peroxisome proliferator activated receptor alpha Rattus norvegicus 15-29 33808880-5 2021 LPS induced release of NO and IL-6 is not significantly reduced by incubation with PPARbeta/delta ligands (either agonist or antagonist), however, co-incubation with an agonist and antagonist significantly reduces LPS-induced nitrite production and Nos2 mRNA expression. Nitrites 226-233 nitric oxide synthase 2 Rattus norvegicus 249-253 33808880-10 2021 Agonist binding followed by antagonist simultaneously switches the PPARbeta/delta mode of action from induction to transrepression, which is linked with an increase in Nos2 mRNA expression and nitrite production. Nitrites 193-200 peroxisome proliferator activated receptor alpha Rattus norvegicus 67-75 33543749-0 2021 Influence of the heme distal pocket on nitrite binding orientation and reactivity in Sperm Whale myoglobin. Nitrites 39-46 myoglobin Physeter catodon 97-106 33543749-1 2021 Nitrite binding to recombinant wild-type Sperm Whale myoglobin (SWMb) was studied using a combination of spectroscopic methods including room-temperature magnetic circular dichroism. Nitrites 0-7 myoglobin Physeter catodon 53-62 33543749-4 2021 Substitution of the proximal heme ligand, histidine-93, with lysine yields a novel form of myoglobin (H93K) with enhanced reactivity towards nitrite. Nitrites 141-148 myoglobin Physeter catodon 91-100 22778905-6 2012 Coherent with the decreased iNOS, eNOS and DDAH-1 expression a decrease in nitrite levels and DDAH activity was observed in the OTA + C3G group. Nitrites 75-82 dimethylarginine dimethylaminohydrolase 1 Rattus norvegicus 43-49 22778905-6 2012 Coherent with the decreased iNOS, eNOS and DDAH-1 expression a decrease in nitrite levels and DDAH activity was observed in the OTA + C3G group. Nitrites 75-82 Rap guanine nucleotide exchange factor 1 Rattus norvegicus 134-137 34863604-4 2022 Nitrite exhibited a linear relationship with the grayscale of the gel interface in the range of 0.3-9 mug mL-1 with a detection limit of 0.3 mug mL-1. Nitrites 0-7 L1 cell adhesion molecule Mus musculus 106-110 34863604-4 2022 Nitrite exhibited a linear relationship with the grayscale of the gel interface in the range of 0.3-9 mug mL-1 with a detection limit of 0.3 mug mL-1. Nitrites 0-7 L1 cell adhesion molecule Mus musculus 145-149 34215856-14 2022 GS expressed a complete nap operon for periplasmic nitrate reduction to nitrite, and a putative octaheme cytochrome c (pOCC), whose involvement in nitrite reduction to ammonium remains to be verified. Nitrites 147-154 cytochrome c, somatic Homo sapiens 105-117 34826614-5 2022 Downregulated expression of mbp and bdnf associated with myelination of nerve fibers further confirmed that MC-LR and nitrite could damage the structure and function of neuron. Nitrites 118-125 myelin basic protein a Danio rerio 28-31 34826614-5 2022 Downregulated expression of mbp and bdnf associated with myelination of nerve fibers further confirmed that MC-LR and nitrite could damage the structure and function of neuron. Nitrites 118-125 brain-derived neurotrophic factor Danio rerio 36-40 34772633-4 2022 The simplified method presented a wide linear range of nitrite between 0.091 mug mL-1 and 1.47 mug mL-1, a sensitivity of 0.447 Abs mL microg-1, a determination coefficient of 0.998, and a low limit of detection of 0.053 mug mL-1. Nitrites 55-62 L1 cell adhesion molecule Mus musculus 81-94 34772633-4 2022 The simplified method presented a wide linear range of nitrite between 0.091 mug mL-1 and 1.47 mug mL-1, a sensitivity of 0.447 Abs mL microg-1, a determination coefficient of 0.998, and a low limit of detection of 0.053 mug mL-1. Nitrites 55-62 L1 cell adhesion molecule Mus musculus 99-103 34772633-4 2022 The simplified method presented a wide linear range of nitrite between 0.091 mug mL-1 and 1.47 mug mL-1, a sensitivity of 0.447 Abs mL microg-1, a determination coefficient of 0.998, and a low limit of detection of 0.053 mug mL-1. Nitrites 55-62 L1 cell adhesion molecule Mus musculus 225-229 34772633-8 2022 The developed method was furtherly applied in the determination of nitrite using a developed paper-based analytical device that detected a nitrite concentration of 3 mug mL-1 which is considered by the World Health Organization to be the maximal permissible limit of nitrite in drinking water. Nitrites 67-74 L1 cell adhesion molecule Mus musculus 170-174 34772633-8 2022 The developed method was furtherly applied in the determination of nitrite using a developed paper-based analytical device that detected a nitrite concentration of 3 mug mL-1 which is considered by the World Health Organization to be the maximal permissible limit of nitrite in drinking water. Nitrites 139-146 L1 cell adhesion molecule Mus musculus 170-174 34772633-8 2022 The developed method was furtherly applied in the determination of nitrite using a developed paper-based analytical device that detected a nitrite concentration of 3 mug mL-1 which is considered by the World Health Organization to be the maximal permissible limit of nitrite in drinking water. Nitrites 267-274 L1 cell adhesion molecule Mus musculus 170-174 34940921-4 2022 We measured plasma and CSF nitrite and nitrate levels in patients with PD with and without LID and in healthy controls. Nitrites 27-34 colony stimulating factor 2 Homo sapiens 23-26 34940921-5 2022 The levels of plasma and CSF nitrite and nitrate were measured by ozone-based chemiluminescence. Nitrites 29-36 colony stimulating factor 2 Homo sapiens 25-28 34940921-7 2022 CSF nitrite levels in patients with PD and LID were higher than in patients with PD without LID and healthy controls. Nitrites 4-11 colony stimulating factor 2 Homo sapiens 0-3 34940921-8 2022 CSF/plasma ratio of nitrite was higher in patients with PD and LID than in patients with PD without LID. Nitrites 20-27 colony stimulating factor 2 Homo sapiens 0-3 34940921-9 2022 The CSF/plasma ratio of nitrite in patients with PD and LID was higher than 1, indicating an intrathecal production of NO in patients with this motor complication. Nitrites 24-31 colony stimulating factor 2 Homo sapiens 4-7 33508993-3 2021 Given the ability of NO to mediate vasodilation and inhibit platelet aggregation, this CA II activity would represent a bioactivation of nitrite. Nitrites 137-144 carbonic anhydrase 2 Homo sapiens 87-92 33508993-5 2021 Here, we provide new experimental data in support of the nitrous anhydrase activity of CA II and the key role L-cysteine in the bioactivation of nitrite by CA II. Nitrites 145-152 carbonic anhydrase 2 Homo sapiens 156-161 33508993-6 2021 Using washed human platelets and by measuring VASP phosphorylation we provide evidence that exogenous nitrite (10 microM) is bioactivated to NO in a manner strongly depending on L-cysteine (100 and 200 microM). Nitrites 102-109 vasodilator stimulated phosphoprotein Homo sapiens 46-50 34829110-5 2021 A correlation analysis indicated that the relationships between residual nitrite contents and total PAH8 contents (tau = 0.692, p < 0.01) and total NAs contents (tau = 0.805, p < 0.01) were characterized with a positive correlation. Nitrites 73-80 microtubule associated protein tau Homo sapiens 115-118 34829110-5 2021 A correlation analysis indicated that the relationships between residual nitrite contents and total PAH8 contents (tau = 0.692, p < 0.01) and total NAs contents (tau = 0.805, p < 0.01) were characterized with a positive correlation. Nitrites 73-80 microtubule associated protein tau Homo sapiens 162-165 34313417-3 2021 Outside of the primary NOS-dependent biosynthetic pathway, other hemoproteins, including hemoglobin and myoglobin, generate NO via the reduction of nitrite. Nitrites 148-155 myoglobin Homo sapiens 104-113 34570637-10 2022 The possible involvement of a HIF/NF-kappaB/iNOS signaling pathway in the process of early vasculogenesis is suggested by the inverse relationship observed between nitrite reduction and NOS activation between HH10 and HH13 stages. Nitrites 164-171 nitric oxide synthase 2 Gallus gallus 44-48 34688205-0 2022 Influence of heme propionates on the nitrite reductase activity of myoglobin. Nitrites 37-44 myoglobin Equus caballus 67-76 34967938-7 2021 RESULTS: Administration of Klotho protein resulted in mitigation of injury, decreased level of NOX2 and NOX4, reduced generation of ROS/RNS and hydrogen peroxide (H2O2), decreased expression of inducible NOS and limited production of nitrates/nitrites in cells under I/R. Nitrites 243-251 klotho Homo sapiens 27-33 34968494-11 2022 Inorganic nitrites and nitrates can decrease the risk for osteoporotic fracture probably directly by decreasing osteoclast activity, decreasing fat accumulation in the marrow cavity, increasing osteoblast activity, and increasing bone perfusion or indirectly, by improving hyperglycemia, insulin resistance, and reducing body weight. Nitrites 10-18 insulin Homo sapiens 288-295 34739044-7 2021 Moreover, "M1-like" interstitial macrophage numbers, nitrite and interferon production were significantly increased in IL-4i1 -/- mice when compared to wild-type mice during acute Mtb HN878 infection. Nitrites 53-60 interleukin 4 induced 1 Mus musculus 119-125 34909830-7 2021 Additionally, Hex-Mn preserved body weight gain, preserved the hepatic glycogen content, and also reduced the thiobarbituric acid reactive substances and nitrite levels, as well as restored the superoxide dismutase. Nitrites 154-161 hematopoietically expressed homeobox Rattus norvegicus 14-17 34225116-4 2021 In this study, a nitrite-rich wastewater (STL, pH = 7.9) was reused as a composting moisture conditioning agent. Nitrites 17-24 RNF217 antisense RNA 1 (head to head) Homo sapiens 42-45 34225116-8 2021 Nitrite addition also stimulated nitrous oxide emissions yielded by biotic or chemical processes during STL addition, especially under the transient condition at 50 C-55 C, and resulted in a 28%-39% increase in greenhouse gas emissions compared with that of the control group. Nitrites 0-7 RNF217 antisense RNA 1 (head to head) Homo sapiens 104-107 34592471-5 2021 Results showed that recombinant endocan treatment in HUVEC could increase NO and nitrite levels. Nitrites 81-88 endothelial cell specific molecule 1 Homo sapiens 32-39 34943874-5 2021 In contrast, the very low levels of Ngb (~1 muM) in most tissues and organs support (pseudo-)enzymatic properties including NO/O2 metabolism, peroxynitrite and free radical scavenging, nitrite, hydroxylamine, hydrogen sulfide reduction, and the nitration of aromatic compounds. Nitrites 185-192 neuroglobin Mus musculus 36-39 34864344-4 2021 The results showed that NH4+ was efficiently oxidized to NO3-, mainly by ammonia- and nitrite-oxidizing bacteria in the oxic media, regardless of the configurations of the bioretention systems or stormwater conditions. Nitrites 86-93 NBL1, DAN family BMP antagonist Homo sapiens 57-60 34827886-3 2021 The alien species occurrences correlated positively (p < 0.05) with poor water quality, such as rivers with high ammonia-nitrogen and nitrite, but negatively with phosphate and dissolved oxygen. Nitrites 134-141 COP9 signalosome subunit 2 Homo sapiens 4-9 34371196-9 2021 The baseline platelet activity, determined as P-selectin expression, negatively correlated with nitrite in plasma and post-mouthwash stimulated saliva. Nitrites 96-103 selectin P Homo sapiens 46-56 34358651-4 2021 To enhance the efficiency of MnSOD in removing ROS and reducing oxidative caused by nitrite, in this study, we cloned grouper MnSOD (gMnSOD) fused with a cell-penetrating peptide, TAT, to construct a TAT-gMnSOD fusion protein and assessed its potential to eliminate excess ROS induced by high nitrite concentrations and enhance the resistance of zebrafish to environmental stressors. Nitrites 84-91 superoxide dismutase 2, mitochondrial Danio rerio 29-34 34358651-4 2021 To enhance the efficiency of MnSOD in removing ROS and reducing oxidative caused by nitrite, in this study, we cloned grouper MnSOD (gMnSOD) fused with a cell-penetrating peptide, TAT, to construct a TAT-gMnSOD fusion protein and assessed its potential to eliminate excess ROS induced by high nitrite concentrations and enhance the resistance of zebrafish to environmental stressors. Nitrites 84-91 superoxide dismutase 2, mitochondrial Danio rerio 126-131 34358651-4 2021 To enhance the efficiency of MnSOD in removing ROS and reducing oxidative caused by nitrite, in this study, we cloned grouper MnSOD (gMnSOD) fused with a cell-penetrating peptide, TAT, to construct a TAT-gMnSOD fusion protein and assessed its potential to eliminate excess ROS induced by high nitrite concentrations and enhance the resistance of zebrafish to environmental stressors. Nitrites 293-300 superoxide dismutase 2, mitochondrial Danio rerio 29-34 34358651-4 2021 To enhance the efficiency of MnSOD in removing ROS and reducing oxidative caused by nitrite, in this study, we cloned grouper MnSOD (gMnSOD) fused with a cell-penetrating peptide, TAT, to construct a TAT-gMnSOD fusion protein and assessed its potential to eliminate excess ROS induced by high nitrite concentrations and enhance the resistance of zebrafish to environmental stressors. Nitrites 293-300 superoxide dismutase 2, mitochondrial Danio rerio 126-131 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 9-16 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 46-51 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 9-16 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 60-66 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 9-16 fructose-bisphosphatase 2 Rattus norvegicus 75-81 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 9-16 PPARG coactivator 1 alpha Rattus norvegicus 101-111 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 9-16 forkhead box O1 Rattus norvegicus 124-129 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 9-16 forkhead box O1 Rattus norvegicus 231-236 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 196-203 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 46-51 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 196-203 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 60-66 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 196-203 fructose-bisphosphatase 2 Rattus norvegicus 75-81 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 196-203 PPARG coactivator 1 alpha Rattus norvegicus 101-111 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 196-203 forkhead box O1 Rattus norvegicus 124-129 34352258-8 2021 RESULTS: Nitrite decreased mRNA expression of PEPCK by 39%, G6Pase by 43%, FBPase by 41%, PC by 63%, PGC-1alpha by 45%, and FoxO1 by 27% in the renal tissue of rats with T2D; co-administration of nitrite and NaSH further decreases FoxO1, while had no additive effects on the tissue expression of the other genes. Nitrites 196-203 forkhead box O1 Rattus norvegicus 231-236 34647205-0 2022 NO3- is an important driver of nitrite-dependent anaerobic methane oxidation bacteria and CH4 fluxes in the reservoir riparian zone. Nitrites 31-38 NBL1, DAN family BMP antagonist Homo sapiens 0-3 34572594-9 2021 A strong association of Fg with neuronal PrPC and ICAM-1, accompanied with overexpression of IL-6 and enhanced generation of ROS, mitochondrial superoxide, and nitrite as well as the resulting neuronal death, was found. Nitrites 160-167 intercellular adhesion molecule 1 Mus musculus 50-56 34679685-1 2021 The depletion of nitrate and nitrite, stable nitric oxide (NO) end-products, promotes adipose tissue dysfunction and insulin resistance (IR). Nitrites 29-36 insulin Homo sapiens 117-124 34572594-10 2021 These effects were reduced by blocking the function of neuronal PrPC and ICAM-1, suggesting that the direct interaction of Fg with its neuronal receptors can induce overexpression of IL-6 and increase the generation of ROS, nitrite, and mitochondrial superoxide, ultimately leading to neuronal death. Nitrites 224-231 intercellular adhesion molecule 1 Mus musculus 73-79 34078001-6 2021 RESULTS: We found that FA activated SIRT1/AMPK/PGC-1alpha signaling pathway and attenuated IL-1beta-induced osteoarthritis chondrocyte degeneration by suppressing the production of IL-6, PGE2 , nitrite, Collagen I, Runx-2, MMP-1, MMP-3, and MMP-13, enhancing Collagen II and Aggrecan expression and inhibiting oxidative stress. Nitrites 194-201 interleukin 1 alpha Homo sapiens 91-99 34252698-5 2021 In addition, nitrite caused immune responses, including a decrease in lysozyme content and an increase in total complement activity, interleukin-6, and heme oxygenase concentrations in the serum. Nitrites 13-20 interleukin-6 Pelodiscus sinensis 133-146 34252698-9 2021 Among them, the glutathione S-transferase omega 1 (GSTO1) gene may relieve nitrite-induced oxidative damage in P. sinensis by participating in a variety of redox-related pathways, while the PPAR signaling pathway has been proposed to play an important regulatory role in lipid metabolism and immune responses. Nitrites 75-82 glutathione S-transferase omega-1 Pelodiscus sinensis 16-49 34252698-9 2021 Among them, the glutathione S-transferase omega 1 (GSTO1) gene may relieve nitrite-induced oxidative damage in P. sinensis by participating in a variety of redox-related pathways, while the PPAR signaling pathway has been proposed to play an important regulatory role in lipid metabolism and immune responses. Nitrites 75-82 glutathione S-transferase omega-1 Pelodiscus sinensis 51-56 34309015-4 2021 Inorganic nitrate (NO3 - ), through chemical reduction to nitrite and then NO, exerts potent BP-lowering but whether it might be useful in treating undesirable cardiac remodelling is unknown. Nitrites 58-65 NBL1, DAN family BMP antagonist Homo sapiens 19-22 34244826-8 2021 In addition, associations between concentrations of BDNF and neopterin as well as serum nitrite levels were found in patients after rTMS treatment, which indicates an influence of immune regulatory circuits on BDNF levels. Nitrites 88-95 brain derived neurotrophic factor Homo sapiens 210-214 34088102-4 2021 Based on the correlation analysis, the number of nitrifying bacteria was significantly positively correlated with NO3- and nxrA abundance, indicating that sucrose amendment promoted the growth of nitrifying bacteria, the contents of NO3- and the activity of nitrite oxidation. Nitrites 258-265 NBL1, DAN family BMP antagonist Homo sapiens 114-117 34309015-6 2021 In mouse models of cardiac remodelling, we also show that restoration of circulating nitrite levels using dietary nitrate improves endothelial dysfunction through targeting of xanthine oxidoreductase (XOR)-driven H2 O2 and superoxide, and reduces cardiac fibrosis through NO-mediated block of SMAD-phosphorylation leading to improvements in cardiac structure and function. Nitrites 85-92 xanthine dehydrogenase Mus musculus 176-199 34309015-6 2021 In mouse models of cardiac remodelling, we also show that restoration of circulating nitrite levels using dietary nitrate improves endothelial dysfunction through targeting of xanthine oxidoreductase (XOR)-driven H2 O2 and superoxide, and reduces cardiac fibrosis through NO-mediated block of SMAD-phosphorylation leading to improvements in cardiac structure and function. Nitrites 85-92 xanthine dehydrogenase Mus musculus 201-204 34064664-7 2021 Exposure to Ang II increased cell surface area, intracellular superoxide anion level, NADPH oxidase and inducible nitric oxide synthase activities, and reduced cellular superoxide dismutase activity and nitrite level, which were similarly reversed by both rutin and quercetin. Nitrites 203-210 angiotensinogen Rattus norvegicus 12-18 34257803-7 2021 In contrast, testicular damage was generally attenuated in the nitrite treatment groups due to a reduction in superoxide and peroxynitrite levels and the inhibition of caspase-3-dependent apoptosis (P < 0.05 vs. group B). Nitrites 63-70 caspase 3 Rattus norvegicus 168-177 34297254-5 2021 Induction of chemokines/cytokines at the mRNA level by LPS and resiquimod were, in general, only marginally affected by MAP kinase inhibition, and expression of TNF, Ccl2 and Ccl5 mRNAs, along with nitrite production, were enhanced by p38 inhibition in a stimulus-specific manner. Nitrites 198-205 mitogen-activated protein kinase 14 Mus musculus 235-238 34135407-6 2021 In HTR-8/SVneo cells, the COX-2 inhibitors induced an increase of IL-6 and nitrite and decreased IL-4 and TGF-beta1. Nitrites 75-82 mitochondrially encoded cytochrome c oxidase II Homo sapiens 26-31 35240169-6 2022 This decrease in current (DeltaI) had a linear relationship with the nitrite concentration in the range of 0.1 to 1 mg L-1 and 1 to 10 mg L-1, which was corresponding to the sensitivities of 48.62 and 2.24 muA mM-1 cm-2, respectively. Nitrites 69-76 L1 cell adhesion molecule Homo sapiens 119-128 34326021-7 2021 In diabetic rats, nitrite administration significantly increased gene expression of glucokinase, synaptotagmin III, syntaxin1A, SNAP25, Munc18b, and insulin genes as well as increased protein expression of proinsulin and C-peptide. Nitrites 18-25 glucokinase Rattus norvegicus 84-95 34326021-7 2021 In diabetic rats, nitrite administration significantly increased gene expression of glucokinase, synaptotagmin III, syntaxin1A, SNAP25, Munc18b, and insulin genes as well as increased protein expression of proinsulin and C-peptide. Nitrites 18-25 synaptotagmin 3 Rattus norvegicus 97-114 34326021-7 2021 In diabetic rats, nitrite administration significantly increased gene expression of glucokinase, synaptotagmin III, syntaxin1A, SNAP25, Munc18b, and insulin genes as well as increased protein expression of proinsulin and C-peptide. Nitrites 18-25 syntaxin 1A Rattus norvegicus 116-126 34326021-7 2021 In diabetic rats, nitrite administration significantly increased gene expression of glucokinase, synaptotagmin III, syntaxin1A, SNAP25, Munc18b, and insulin genes as well as increased protein expression of proinsulin and C-peptide. Nitrites 18-25 synaptosome associated protein 25 Rattus norvegicus 128-134 34326021-7 2021 In diabetic rats, nitrite administration significantly increased gene expression of glucokinase, synaptotagmin III, syntaxin1A, SNAP25, Munc18b, and insulin genes as well as increased protein expression of proinsulin and C-peptide. Nitrites 18-25 syntaxin binding protein 2 Rattus norvegicus 136-143 34326021-8 2021 CONCLUSION: Stimulatory effect of nitrite on insulin secretion in Type 2 diabetic rats is at least in part due to increased gene expression of molecules involved in glucose sensing (glucokinase), calcium sensing (synaptotagmin III), and exocytosis of insulin vesicles (syntaxin1A, SNAP25, and Munc18b) as well as increased expression of insulin genes. Nitrites 34-41 glucokinase Rattus norvegicus 182-193 34326021-8 2021 CONCLUSION: Stimulatory effect of nitrite on insulin secretion in Type 2 diabetic rats is at least in part due to increased gene expression of molecules involved in glucose sensing (glucokinase), calcium sensing (synaptotagmin III), and exocytosis of insulin vesicles (syntaxin1A, SNAP25, and Munc18b) as well as increased expression of insulin genes. Nitrites 34-41 synaptotagmin 3 Rattus norvegicus 213-230 34326021-8 2021 CONCLUSION: Stimulatory effect of nitrite on insulin secretion in Type 2 diabetic rats is at least in part due to increased gene expression of molecules involved in glucose sensing (glucokinase), calcium sensing (synaptotagmin III), and exocytosis of insulin vesicles (syntaxin1A, SNAP25, and Munc18b) as well as increased expression of insulin genes. Nitrites 34-41 syntaxin 1A Rattus norvegicus 269-279 34326021-8 2021 CONCLUSION: Stimulatory effect of nitrite on insulin secretion in Type 2 diabetic rats is at least in part due to increased gene expression of molecules involved in glucose sensing (glucokinase), calcium sensing (synaptotagmin III), and exocytosis of insulin vesicles (syntaxin1A, SNAP25, and Munc18b) as well as increased expression of insulin genes. Nitrites 34-41 synaptosome associated protein 25 Rattus norvegicus 281-287 34326021-8 2021 CONCLUSION: Stimulatory effect of nitrite on insulin secretion in Type 2 diabetic rats is at least in part due to increased gene expression of molecules involved in glucose sensing (glucokinase), calcium sensing (synaptotagmin III), and exocytosis of insulin vesicles (syntaxin1A, SNAP25, and Munc18b) as well as increased expression of insulin genes. Nitrites 34-41 syntaxin binding protein 2 Rattus norvegicus 293-300 35504499-9 2022 Nitrite treatment decreased inducible and neuronal NO synthases (iNOS, 0.4-fold; nNOS, 0.4-fold) and cystathionine beta-synthase (CBS, 0.1-fold) expression in the isolated heart from rats with T2D. Nitrites 0-7 nitric oxide synthase 2 Rattus norvegicus 65-69 35504499-9 2022 Nitrite treatment decreased inducible and neuronal NO synthases (iNOS, 0.4-fold; nNOS, 0.4-fold) and cystathionine beta-synthase (CBS, 0.1-fold) expression in the isolated heart from rats with T2D. Nitrites 0-7 nitric oxide synthase 1 Rattus norvegicus 81-85 35504499-9 2022 Nitrite treatment decreased inducible and neuronal NO synthases (iNOS, 0.4-fold; nNOS, 0.4-fold) and cystathionine beta-synthase (CBS, 0.1-fold) expression in the isolated heart from rats with T2D. Nitrites 0-7 cystathionine beta synthase Rattus norvegicus 101-128 35504499-10 2022 Co-administration of nitrite and NaSH further increased cystathionine gamma-lyase (CSE, 2.8-fold) and endothelial NOS (eNOS, 2.0-fold) expression and further decreased iNOS (0.4-fold) expression. Nitrites 21-28 cystathionine gamma-lyase Rattus norvegicus 56-81 35504499-10 2022 Co-administration of nitrite and NaSH further increased cystathionine gamma-lyase (CSE, 2.8-fold) and endothelial NOS (eNOS, 2.0-fold) expression and further decreased iNOS (0.4-fold) expression. Nitrites 21-28 cystathionine gamma-lyase Rattus norvegicus 83-86 35504499-10 2022 Co-administration of nitrite and NaSH further increased cystathionine gamma-lyase (CSE, 2.8-fold) and endothelial NOS (eNOS, 2.0-fold) expression and further decreased iNOS (0.4-fold) expression. Nitrites 21-28 nitric oxide synthase 3 Rattus norvegicus 102-117 35504499-10 2022 Co-administration of nitrite and NaSH further increased cystathionine gamma-lyase (CSE, 2.8-fold) and endothelial NOS (eNOS, 2.0-fold) expression and further decreased iNOS (0.4-fold) expression. Nitrites 21-28 nitric oxide synthase 2 Rattus norvegicus 168-172 35504499-12 2022 These anti-ischemic effects, following co-administration of nitrite and NaSH, were associated with higher CSE-derived H2S and eNOS-derived NO as well as lower iNOS-derived NO in the diabetic hearts. Nitrites 60-67 cystathionine gamma-lyase Rattus norvegicus 106-109 35504499-12 2022 These anti-ischemic effects, following co-administration of nitrite and NaSH, were associated with higher CSE-derived H2S and eNOS-derived NO as well as lower iNOS-derived NO in the diabetic hearts. Nitrites 60-67 nitric oxide synthase 2 Rattus norvegicus 159-163 35472539-2 2022 Herein, for the first time, a robust dual-response fluorescent sensor CGT with two different emission fluorophores and dual well-known response-group for visual bisulphites (HSO3-) and nitrites (NO2-) detection was reported. Nitrites 185-193 UDP glycosyltransferase 8 Homo sapiens 70-73 35240169-6 2022 This decrease in current (DeltaI) had a linear relationship with the nitrite concentration in the range of 0.1 to 1 mg L-1 and 1 to 10 mg L-1, which was corresponding to the sensitivities of 48.62 and 2.24 muA mM-1 cm-2, respectively. Nitrites 69-76 Mix1 homeobox-like 1 (Xenopus laevis) Mus musculus 210-219 35339022-2 2022 After ingesting sodium nitrite, nitrite ions oxidize hemoglobin to methemoglobin in red blood cells (RBCs), causing methemoglobinemia which can be fatal depending on the severity. Nitrites 32-39 hemoglobin subunit gamma 2 Homo sapiens 67-80 35503583-6 2022 In addition, the LaAlO3@GO/GCE electrode displayed excellent selectivity, repeatability, reproducibility, storage, and operational stability toward nitrite detection. Nitrites 148-155 glycine cleavage system protein H Homo sapiens 17-30 35592612-7 2022 Notably, insulin-sensitive glucose uptake is increased synergistically by nitrite. Nitrites 74-81 insulin Homo sapiens 9-16 35278812-7 2022 Nitrites significantly correlated with IL-8 during relapse. Nitrites 0-8 C-X-C motif chemokine ligand 8 Homo sapiens 39-43 35351554-5 2022 Besides, the potential selecting advantage of nitrate reducing bacteria over nitrite reducing bacteria and the enrichment of dissimilatory nitrate reduction to ammonium (DNRA) bacteria could be responsible for the nitrite and ammonia accumulation at pH 3. Nitrites 77-84 phenylalanine hydroxylase Homo sapiens 250-252 35351554-5 2022 Besides, the potential selecting advantage of nitrate reducing bacteria over nitrite reducing bacteria and the enrichment of dissimilatory nitrate reduction to ammonium (DNRA) bacteria could be responsible for the nitrite and ammonia accumulation at pH 3. Nitrites 214-221 phenylalanine hydroxylase Homo sapiens 250-252 35266499-6 2022 In this review, we discuss the active site environment, electronic structure, spectroscopic and electrochemical properties, and some interesting reactivities exhibited by the heme-Cu-Abeta complex with small molecules, such as oxygen (O2), nitric oxide (NO) and nitrite (NO2-). Nitrites 262-269 amyloid beta precursor protein Homo sapiens 183-188 35366369-6 2022 Both ARC1 and ARC2 from Arabidopsis could reduce N-hydroxylated compounds, while nitrite reduction to form NO could only be demonstrated for ARC2. Nitrites 81-88 FtsH extracellular protease family Arabidopsis thaliana 5-9 35217293-0 2022 Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1alpha pathway. Nitrites 22-29 thymoma viral proto-oncogene 1 Mus musculus 147-150 35217293-0 2022 Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1alpha pathway. Nitrites 22-29 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 151-160 35217293-10 2022 In human proximal tubule epithelial cells (HK-2), inorganic nitrite treatment prevented transforming growth factor beta-induced pro-fibrotic changes. Nitrites 60-67 tumor necrosis factor Homo sapiens 88-119 35217293-11 2022 Mechanistically, boosting the nitrate-nitrite-NO pathway promoted AMP-activated protein kinase (AMPK) phosphorylation, improved AKT-mediated peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) activity and restored mitochondrial function. Nitrites 38-45 thymoma viral proto-oncogene 1 Mus musculus 128-131 35217293-11 2022 Mechanistically, boosting the nitrate-nitrite-NO pathway promoted AMP-activated protein kinase (AMPK) phosphorylation, improved AKT-mediated peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) activity and restored mitochondrial function. Nitrites 38-45 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 141-209 35217293-11 2022 Mechanistically, boosting the nitrate-nitrite-NO pathway promoted AMP-activated protein kinase (AMPK) phosphorylation, improved AKT-mediated peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) activity and restored mitochondrial function. Nitrites 38-45 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 211-220 35150744-5 2022 In each of these two cases, the maximum amount of nitrite or nitrate formed was at best stoichiometric with the concentration of Mka HLP. Nitrites 50-57 HLP Homo sapiens 133-136 35344129-6 2022 Results showed increased physical activity in mice under behavioural tests, plasma nitrite and malondialdehyde (MDA) levels and monoamine oxidase A (MAO-A) activity decreased dose-dependently in MIS treated mice and superoxide dismutases (SOD) levels increased in treated groups as compared to disease control. Nitrites 83-90 anti-Mullerian hormone Mus musculus 195-198 35304512-9 2022 These findings suggest that nitrite impairs the fermentation ability of yeast by inhibiting the Pdc1 activity via its PTN modification at Tyr157 and Tyr344 of Pdc1. Nitrites 28-35 indolepyruvate decarboxylase 1 Saccharomyces cerevisiae S288C 96-100 35304512-9 2022 These findings suggest that nitrite impairs the fermentation ability of yeast by inhibiting the Pdc1 activity via its PTN modification at Tyr157 and Tyr344 of Pdc1. Nitrites 28-35 indolepyruvate decarboxylase 1 Saccharomyces cerevisiae S288C 159-163 35074739-6 2022 Meanwhile, high nitrite induced skin lesions in mice, accompanied with increased serum ALT, colon IL-6, TNF-alpha, and MDA levels, together with decreased serum Cr, colon sIgA, and T-AOC levels. Nitrites 16-23 glutamic pyruvic transaminase, soluble Mus musculus 87-90 35142315-5 2022 The oxygen atom transfer nitrite reduction of the Cu(II) nitrite complexes leads to the formation of copper(I)-PPh3 and O PPh3 which were confirmed by 1H and 31P NMR. Nitrites 25-32 caveolin 1 Homo sapiens 111-115 35142315-5 2022 The oxygen atom transfer nitrite reduction of the Cu(II) nitrite complexes leads to the formation of copper(I)-PPh3 and O PPh3 which were confirmed by 1H and 31P NMR. Nitrites 25-32 caveolin 1 Homo sapiens 122-126 35269826-0 2022 Nitrite Concentration in the Striated Muscles Is Reversely Related to Myoglobin and Mitochondrial Proteins Content in Rats. Nitrites 0-7 myoglobin Rattus norvegicus 70-79 35391922-2 2022 At least two major pathways produce NO: (1) the L-arginine-NO-oxidative pathway in which NO synthase (NOS) enzymes convert L-arginine to NO; (2) the nitrate-nitrite-NO reductive pathway in which NO is produced from the serial reduction of nitrate and nitrite. Nitrites 251-258 nitric oxide synthase 2 Homo sapiens 89-100 35074739-6 2022 Meanwhile, high nitrite induced skin lesions in mice, accompanied with increased serum ALT, colon IL-6, TNF-alpha, and MDA levels, together with decreased serum Cr, colon sIgA, and T-AOC levels. Nitrites 16-23 interleukin 6 Mus musculus 98-102 35074739-6 2022 Meanwhile, high nitrite induced skin lesions in mice, accompanied with increased serum ALT, colon IL-6, TNF-alpha, and MDA levels, together with decreased serum Cr, colon sIgA, and T-AOC levels. Nitrites 16-23 tumor necrosis factor Mus musculus 104-113 35074739-6 2022 Meanwhile, high nitrite induced skin lesions in mice, accompanied with increased serum ALT, colon IL-6, TNF-alpha, and MDA levels, together with decreased serum Cr, colon sIgA, and T-AOC levels. Nitrites 16-23 periphilin 1 Mus musculus 161-163 35074739-9 2022 Inversely, gut microbiota from normal mice reduced the effects of nitrite on serum ALT and Cr, together with colon sIgA and MDA. Nitrites 66-73 glutamic pyruvic transaminase, soluble Mus musculus 83-86 35074739-12 2022 In addition, AOM exhibited to be more toxic to the colon in the nitrite-treated mice in comparison with normal water-treated mice, and it might be due to the expression of Hspa1a and Hspa1b in the colon. Nitrites 64-71 heat shock protein 1A Mus musculus 172-178 35074739-12 2022 In addition, AOM exhibited to be more toxic to the colon in the nitrite-treated mice in comparison with normal water-treated mice, and it might be due to the expression of Hspa1a and Hspa1b in the colon. Nitrites 64-71 heat shock protein 1B Mus musculus 183-189 35163124-1 2022 The two homologous genes, NIA1 and NIA2, encode nitrate reductases in Arabidopsis, which govern the reduction of nitrate to nitrite. Nitrites 124-131 nitrate reductase 1 Arabidopsis thaliana 26-30 35197735-5 2022 In renal samples of rats treated with CCl4, the antioxidant enzymes (POD, SOD, CAT), PH level, protein level, and glutathione contents were significantly (p < 0.05) declined whereas renal biochemicals (H2O2, TBARS, and nitrite), specific gravity, level of urea, urobilinogen, serum BUN and creatinine were markedly (p < 0.05) increased relative to control group. Nitrites 219-226 C-C motif chemokine ligand 4 Rattus norvegicus 38-42 35163124-1 2022 The two homologous genes, NIA1 and NIA2, encode nitrate reductases in Arabidopsis, which govern the reduction of nitrate to nitrite. Nitrites 124-131 nitrate reductase 2 Arabidopsis thaliana 35-39 35159742-0 2022 A Novel Highly Sensitive Electrochemical Nitrite Sensor Based on a AuNPs/CS/Ti3C2 Nanocomposite. Nitrites 41-48 citrate synthase Homo sapiens 73-75 34151866-12 2022 Nitrite levels in media were lower for DDAH1 SNP LCLs compared to DDAH1 WT LCLs (p < 0.05). Nitrites 0-7 dimethylarginine dimethylaminohydrolase 1 Homo sapiens 39-44 35159742-3 2022 In this paper, we prepared an electrochemical sensor for highly sensitive and selective detection of nitrite, based on AuNPs/CS/MXene nanocomposite. Nitrites 101-108 citrate synthase Homo sapiens 125-127 35047570-5 2021 Furthermore, we found decreased expression of endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) along with elevated expression of endothelial-1(ET1) in HUVECs from IVF offspring, accompanied by lower secretion of nitrite, VEGF, and higher secretion of ET1 in the umbilical cord serum of IVF offspring. Nitrites 250-257 endothelin 1 Homo sapiens 181-184 35045112-11 2022 Both SS+Glu-2 and Glu-2 treatments significantly enhanced (P<0.05) the contents of nitrate (NO3-N) and nitrite (NO2-N), but sharply decreased (P<0.05) the ammonium (NH4+-N) content compared with no glucose addition. Nitrites 103-110 glucan endo-1,3-beta-glucosidase, basic isoform Malus domestica 8-13 35045112-11 2022 Both SS+Glu-2 and Glu-2 treatments significantly enhanced (P<0.05) the contents of nitrate (NO3-N) and nitrite (NO2-N), but sharply decreased (P<0.05) the ammonium (NH4+-N) content compared with no glucose addition. Nitrites 103-110 glucan endo-1,3-beta-glucosidase, basic isoform Malus domestica 18-23 35215227-5 2022 It exhibited scavenging activity of 50-85% at 1-10 mg/mL, it inhibited nitrite production and ICAM-1 expression in TNF-alpha-stimulated endothelial cell cultures dose-dependently, at a maximum of 58.7% at the maximum dose administered and exerted an obvious anti-inflammatory effect in vivo, settling early and decreasing at 180 min; a new herbal bioactive product was presented with promising therapeutic potential that can be an adjunct to conventional therapies for diseases based on oxidative stress and inflammation. Nitrites 71-78 tumor necrosis factor Rattus norvegicus 115-124 35221497-8 2022 Furthermore, TUNEL-positive cells were observed in granulosa cells of atretic follicles, and overexpression of caspase 8, c-Fos, and inducible nitric oxide synthase (iNOS) was detected in ovaries after nitrite exposure (p<0.01), suggesting that cell apoptosis and oxidative stress response were induced following nitrite exposure. Nitrites 202-209 caspase 8 Mus musculus 111-120 35221497-8 2022 Furthermore, TUNEL-positive cells were observed in granulosa cells of atretic follicles, and overexpression of caspase 8, c-Fos, and inducible nitric oxide synthase (iNOS) was detected in ovaries after nitrite exposure (p<0.01), suggesting that cell apoptosis and oxidative stress response were induced following nitrite exposure. Nitrites 202-209 nitric oxide synthase 2, inducible Mus musculus 166-170 35221497-8 2022 Furthermore, TUNEL-positive cells were observed in granulosa cells of atretic follicles, and overexpression of caspase 8, c-Fos, and inducible nitric oxide synthase (iNOS) was detected in ovaries after nitrite exposure (p<0.01), suggesting that cell apoptosis and oxidative stress response were induced following nitrite exposure. Nitrites 313-320 caspase 8 Mus musculus 111-120 35221497-8 2022 Furthermore, TUNEL-positive cells were observed in granulosa cells of atretic follicles, and overexpression of caspase 8, c-Fos, and inducible nitric oxide synthase (iNOS) was detected in ovaries after nitrite exposure (p<0.01), suggesting that cell apoptosis and oxidative stress response were induced following nitrite exposure. Nitrites 313-320 nitric oxide synthase 2, inducible Mus musculus 166-170 35158330-0 2021 Exercise and nitrite prevent and Nomega-nitrol-L-arginine methyl ester reproduces imbalance in the nuclear factor-kappaB/NADPH oxidase 2 and nuclear factor erythroid 2-related factor 2/NADPH oxidase 4/endothelial nitric oxide synthase systems in diabetes. Nitrites 13-20 NFE2 like bZIP transcription factor 2 Rattus norvegicus 141-184 2792974-5 1989 The administration of HSC with nitrite also induced unscheduled DNA synthesis in the pyloric mucosa, but led to decreased induction of ODC, RDS and DNA single-strand breaks in comparison with treatment with HSC alone. Nitrites 31-38 ornithine decarboxylase 1 Rattus norvegicus 135-138 35522874-3 2022 NO-synthase (NOS) activity was determined in oral fluid by the difference in nitrite concentration before and after incubation. Nitrites 77-84 nitric oxide synthase 2 Homo sapiens 0-11 2495172-0 1989 Antiproliferative activity of gamma-interferon combined with lipopolysaccharide on murine adenocarcinoma: dependence on an L-arginine metabolism with production of nitrite and citrulline. Nitrites 164-171 interferon gamma Mus musculus 30-46 2801224-8 1989 In patients with an intermediary ATP value (10-50 nmol/l) a positive nitrite test was used to confirm UTI. Nitrites 69-76 alpha-1-microglobulin/bikunin precursor Homo sapiens 102-105 2495172-3 1989 In the same time, the combination IFN-gamma + lipopolysaccharide induced synergistically the production of nitrite and citrulline by EMT6 cells. Nitrites 107-114 interferon gamma Mus musculus 34-43 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrites 107-114 interferon gamma Mus musculus 12-28 2696586-4 1989 The direct-acting mutagenic products of phenolic compounds with nitrite were all diazo derivatives, and those from indole compounds with nitrite were N-1 and/or C-3 nitrosated products. Nitrites 137-144 complement C3 Homo sapiens 161-164 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrites 107-114 interferon gamma Rattus norvegicus 30-40 3220326-0 1988 Interaction of nitrite with catalase in the perfused rat liver. Nitrites 15-22 catalase Rattus norvegicus 28-36 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrites 107-114 tumor necrosis factor Mus musculus 58-79 3220326-1 1988 The interaction of nitrite with catalase was investigated spectrophotometrically in the perfused rat liver. Nitrites 19-26 catalase Rattus norvegicus 32-40 3220326-6 1988 It was concluded that relatively low concentrations of nitrite caused decomposition of catalase compound I in the physiologically functioning liver cell. Nitrites 55-62 catalase Rattus norvegicus 87-95 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrites 107-114 tumor necrosis factor Rattus norvegicus 81-85 16666314-0 1988 The Conversion of Nitrite to Nitrogen Oxide(s) by the Constitutive NAD(P)H-Nitrate Reductase Enzyme from Soybean. Nitrites 18-25 chalcone reductase CHR1 Glycine max 83-92 3138176-10 1988 If RPCs were activated with IFN-gamma, then serum-opsonized strain 52 was also able to stimulate nitrite synthesis. Nitrites 97-104 interferon gamma Mus musculus 28-37 3049442-4 1988 By contrast, phenylhydrazine, nitrite, hydrogen peroxide, ter-butylhydroperoxide, cumene hydroperoxide and copper-ascorbate caused a noticeable oxidation of hemoglobin to methemoglobin. Nitrites 30-37 hemoglobin subunit gamma 2 Homo sapiens 171-184 2847585-2 1988 The copper-containing nitrite reductase from Achromobacter cycloclastes has been shown to have apparent Km"s for reduced cytochrome c and nitrite of 86 +/- 5 and 5.63 +/- 0.03 microM, respectively. Nitrites 22-29 cytochrome c, somatic Homo sapiens 121-133 3200618-0 1988 [Formation of transferrin and ceruloplasmin in the blood of rats with acute nitrite-induced methemoglobinemia]. Nitrites 76-83 transferrin Rattus norvegicus 14-25 3200618-0 1988 [Formation of transferrin and ceruloplasmin in the blood of rats with acute nitrite-induced methemoglobinemia]. Nitrites 76-83 ceruloplasmin Rattus norvegicus 30-43 3371807-2 1988 When whole blood was stored at 3 degrees C, rapid reduction of Met-Hb was observed in the nitrite-treated blood whereas neither reduction nor formation of Met-Hb was observed in the untreated and heated blood within 7 days. Nitrites 90-97 hemoglobin subunit gamma 2 Homo sapiens 63-69 24221417-8 1988 Subsequently when NiR was induced, nitrite was utilized and NR activity recovered. Nitrites 35-42 nitrate reductase Glycine max 18-21 24221417-9 1988 Nitrate reductase was induced in bacteroids of strain CB1809 when they were incubated in-vitro with nitrate or nitrite. Nitrites 111-118 inducible nitrate reductase [NADH] 1 Glycine max 0-17 3665926-13 1987 The specific nitrite-reducing activity with ascorbate-reduced phenazine methosulfate as electron donor was 1 mumol substrate min-1 mg protein-1. Nitrites 13-20 CD59 molecule (CD59 blood group) Homo sapiens 125-130 3345578-7 1988 At lower mass transfer rates, at lower pH and/or in the presence of SCN- or Cl-, relatively more ASC was consumed by a given amount of nitrite. Nitrites 135-142 PYD and CARD domain containing Homo sapiens 97-100 3345578-8 1988 Increased temperature caused more or less ASC to be consumed by a given amount of nitrite, depending on the conditions. Nitrites 82-89 PYD and CARD domain containing Homo sapiens 42-45 3345578-10 1988 The model predicts the variable stoichiometry of the reaction between nitrite and ASC in open, aerobic systems, and clarifies the mechanisms by which ASC inhibits nitrosation. Nitrites 70-77 PYD and CARD domain containing Homo sapiens 82-85 3345578-10 1988 The model predicts the variable stoichiometry of the reaction between nitrite and ASC in open, aerobic systems, and clarifies the mechanisms by which ASC inhibits nitrosation. Nitrites 70-77 PYD and CARD domain containing Homo sapiens 150-153 3345578-1 1988 Ascorbic acid and ascorbate ion (denoted together as ASC) inhibit nitrosation by competing for the nitrosating agents formed from nitrite (e.g. N2O3, NO+ and NOSCN). Nitrites 130-137 PYD and CARD domain containing Homo sapiens 53-56 3345578-2 1988 ASC is oxidized irreversibly by this reaction and the nitrite equivalents are reduced to nitric oxide (NO). Nitrites 54-61 PYD and CARD domain containing Homo sapiens 0-3 3345578-3 1988 In open, aerobic systems the effective stoichiometry of the reaction between ASC and nitrite is not fixed, but is determined by a competition between the physical removal of NO (and NO2) from the system and the oxidation of NO by dissolved O2. Nitrites 85-92 PYD and CARD domain containing Homo sapiens 77-80 3345578-5 1988 To determine the conditions under which ASC is most effective as a nitrosation inhibitor, we examined the kinetics of the reactions between nitrite and ASC and between nitrite and proline. Nitrites 140-147 PYD and CARD domain containing Homo sapiens 40-43 3345578-5 1988 To determine the conditions under which ASC is most effective as a nitrosation inhibitor, we examined the kinetics of the reactions between nitrite and ASC and between nitrite and proline. Nitrites 168-175 PYD and CARD domain containing Homo sapiens 40-43 2822381-7 1987 The results suggest that during the oxidation, the methemoglobin peroxide compound is generated and converts nitrite into nitrogen dioxide by its peroxidatic activity. Nitrites 109-116 hemoglobin subunit gamma 2 Homo sapiens 51-64 3118602-3 1987 The bacterial nitrite synthesis in gastric juice from porcine stomach mucin and the decrease of nitrite after adding acid, which has often been described in literature-results of an examination with a standardizable biomodel. Nitrites 14-21 LOC100508689 Homo sapiens 70-75 3110273-0 1987 Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma. Nitrites 13-20 interferon gamma Mus musculus 95-111 3110273-1 1987 Macrophage synthesis of nitrite and nitrate after activation by BCG infection or by treatment in vitro with both T cell-derived (lymphokines (LK) or recombinant murine interferon-gamma (IFN-gamma] and bacterial (lipopolysaccharide (LPS) and heat-killed bacillus Calmette-Guerin (hk BCG] agents was studied by using macrophages from C3H/He and C3H/HeJ mice. Nitrites 24-31 interferon gamma Mus musculus 186-195 3110273-5 1987 Recombinant IFN-gamma also stimulated nitrite/nitrate synthesis by C3H/He and CeH/HeJ macrophages as did LPS (C3H/He only) and hk BCG. Nitrites 38-45 interferon gamma Mus musculus 12-21 3110273-6 1987 When given concurrently with either LPS or hk BCG, IFN-gamma enhanced C3H/He and C3H/HeJ macrophage nitrite/nitrate synthesis over that produced by macrophages treated with either LPS or hk BCG alone. Nitrites 100-107 interferon gamma Mus musculus 51-60 3110273-10 1987 Taken together, these results indicate that T cell lymphokines and IFN-gamma are powerful modulators of macrophage nitrite/nitrate synthesis during BCG infection and in vitro, and nitrite/nitrate synthesis appears to be common property of both primed and fully activated macrophage populations. Nitrites 115-122 interferon gamma Mus musculus 67-76 2439225-2 1987 Murine peritoneal macrophages, elicited in vivo with thioglycolate and stimulated in vitro with LPS and/or gamma-interferon (IFN), produce copious amounts of nitrate and nitrite. Nitrites 170-177 interferon gamma Mus musculus 107-129 3002798-7 1986 The cytochrome c552 showed nitrite and hydroxylamine reductase activities with benzyl viologen as an artificial electron donor. Nitrites 27-34 cytochrome c, somatic Homo sapiens 4-16 3032675-1 1987 The ferric spleen green heme-protein exhibits hyperfine-shifted proton resonances between 90 and 20 ppm for the high-spin resting form and the chloride complex, and between 46 and -9.4 ppm for the low-spin nitrite complex. Nitrites 206-213 HEME Bos taurus 24-28 3679397-11 1987 gamma-Interferon (IFN) promoted both NMOR (2.5 microM) and nitrite (70 microM) formation. Nitrites 59-66 interferon gamma Mus musculus 0-22 3586082-5 1987 Methemoglobin level was 2% immediately after nitrite administration. Nitrites 45-52 hemoglobin subunit gamma 2 Homo sapiens 0-13 3085308-10 1986 The effects of nitrates, nitrites and mechanisms of the reconversion of methemoglobin to hemoglobin are discussed. Nitrites 25-33 HGB Sus scrofa 75-85 3530615-9 1986 Nitrites convert hemoglobin to methemoglobin, which reacts with cyanide to form cyanomethemoglobin. Nitrites 0-8 hemoglobin subunit gamma 2 Homo sapiens 31-44 3271881-2 1986 The involvement of cytochrome P-450 (P-450) as the catalyst in 2NP denitrification was revealed by the induction of nitrite-releasing activity following phenobarbital (PB) pretreatment, by a decrease in activity with carbon tetrachloride pretreatment, by the inhibition of the reaction with classical P-450 inhibitors, and by the observation of a type I binding spectrum. Nitrites 116-123 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 19-35 3754494-0 1986 Metabolic nitrite formation from N-nitrosamines: are there other pathways than reductive denitrosation by cytochrome P-450? Nitrites 10-17 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 106-122 3957895-2 1986 The nitrite production from myosin trinitrophenylated in the presence of PPi occurred at the same rate and to the same extent as that from myosin trinitrophenylated in the absence of PPi. Nitrites 4-11 myosin, heavy chain 15 Gallus gallus 28-34 3743868-2 1986 The cytochrome P-450 peroxygenase catalyzed reaction resulted in the production of nitrite and acetone. Nitrites 83-90 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 4-20 24240961-0 1985 Nitrite reduction in barley-root plastids: Dependence on NADPH coupled with glucose-6-phosphate and 6-phosphogluconate dehydrogenases, and possible involvement of an electron carrier and a diaphorase. Nitrites 0-7 2,4-dienoyl-CoA reductase 1 Homo sapiens 57-62 3957895-0 1986 Production of nitrite ions from trinitrophenyl myosin and from trinitrophenyl subfragment-1. Nitrites 14-21 myosin, heavy chain 15 Gallus gallus 47-53 3957895-1 1986 When trinitrophenyl (TNP) myosin of either chicken breast muscle or porcine cardiac muscle was left to stand in an alkaline medium at 20 degrees C for several hours, nitrite ions were found to be gradually produced. Nitrites 166-173 myosin, heavy chain 15 Gallus gallus 26-32 3957895-2 1986 The nitrite production from myosin trinitrophenylated in the presence of PPi occurred at the same rate and to the same extent as that from myosin trinitrophenylated in the absence of PPi. Nitrites 4-11 myosin, heavy chain 15 Gallus gallus 139-145 3957895-3 1986 The nitrite production was significantly reduced when thiols of myosin were modified with 2-nitro-5-thiocyanobenzoate. Nitrites 4-11 myosin, heavy chain 15 Gallus gallus 64-70 24240961-8 1985 The results indicate that both an electron carrier and a diaphorase having ferredoxin-NADP(+) reductase activity are involved in the electron-transport system of root plastids from NADPH, coupled with Glc6PDH and 6PGDH, to nitrite. Nitrites 223-230 2,4-dienoyl-CoA reductase 1 Homo sapiens 181-186 24240961-8 1985 The results indicate that both an electron carrier and a diaphorase having ferredoxin-NADP(+) reductase activity are involved in the electron-transport system of root plastids from NADPH, coupled with Glc6PDH and 6PGDH, to nitrite. Nitrites 223-230 g6pdh Hordeum vulgare 201-208 6321458-9 1984 The nitrosyl donor trapped by these reactions is believed to represent an intermediate in the reduction of nitrite by cytochrome c,d1. Nitrites 107-114 cytochrome c, somatic Homo sapiens 118-130 6424728-3 1984 The steady state methemoglobin levels were maintained by infusion of a nitrite solution at a rate of 2.8 mmol/h/l cells. Nitrites 71-78 hemoglobin subunit gamma 2 Homo sapiens 17-30 3836241-2 1985 Oxidation of hemoglobin to methemoglobin under aerobic conditions is induced by nitrite, catalyzed by methemoglobin in the presence of hydrogen peroxide, and inhibited by chemical reagents ranging from cysteine and ascorbic acid to sulfite. Nitrites 80-87 hemoglobin subunit gamma 2 Homo sapiens 27-40 3836241-2 1985 Oxidation of hemoglobin to methemoglobin under aerobic conditions is induced by nitrite, catalyzed by methemoglobin in the presence of hydrogen peroxide, and inhibited by chemical reagents ranging from cysteine and ascorbic acid to sulfite. Nitrites 80-87 hemoglobin subunit gamma 2 Homo sapiens 102-115 3836241-7 1985 The autocatalytic stage for hemoglobin oxidation results from nitrogen dioxide formed from nitrite through the peroxidase activity of methemoglobin. Nitrites 91-98 hemoglobin subunit gamma 2 Homo sapiens 134-147 3836241-8 1985 Peroxide and methemoglobin are formed during the initiation stage by electron transfer from nitrite that is kinetically first order in oxyhemoglobin and in nitrite. Nitrites 92-99 hemoglobin subunit gamma 2 Homo sapiens 13-26 3836241-8 1985 Peroxide and methemoglobin are formed during the initiation stage by electron transfer from nitrite that is kinetically first order in oxyhemoglobin and in nitrite. Nitrites 156-163 hemoglobin subunit gamma 2 Homo sapiens 13-26 6099057-2 1984 The nitrite method was found to be the best for our SOD assay kit. Nitrites 4-11 superoxide dismutase 1 Homo sapiens 52-55 6471815-2 1984 Butyl nitrite is predominantly converted to butanol, nitrite, and nitrate in acidic water and to butanol, nitrate, and methemoglobin in whole blood; however, butyl nitrite shows little initial conversion to those products in plasma. Nitrites 6-13 hemoglobin subunit gamma 2 Homo sapiens 119-132 6303331-0 1983 Nitrite reactivity of the binuclear copper site in T2D Rhus laccase: preparation of half met-NO2- T2D laccase and its correlation to half met-NO2- hemocyanin and tyrosinase. Nitrites 0-7 tyrosinase Homo sapiens 138-172 6318101-1 1983 In vitro, the reaction, in acidified solution, of the histamine H2 receptor antagonist ranitidine with excess nitrite, yielded nitroso derivative(s) eliciting a dose-dependent amount of unscheduled DNA synthesis in primary cultures of rat hepatocytes. Nitrites 110-117 histamine receptor H 2 Rattus norvegicus 54-75 18551483-6 1983 The NADPH-GDH activity at the outset increased exponentially with time in greenhouse culture but then decreased sharply accompanied by a rapid increase in biomass and nitrite concentration. Nitrites 167-174 glutamate dehydrogenase 1 Homo sapiens 10-13 6533036-1 1984 Nitrite was formed on incubation of N-nitrosamines with both microsomal systems and a reconstituted system consisting of cytochrome P-450 and NADPH P-450 reductase from pig liver. Nitrites 0-7 cytochrome P450 family 2 subfamily D member 6 Sus scrofa 121-137 6131752-1 1983 The in vitro reaction of nitrite with the histamine H2-receptor antagonist ranitidine, in acidified solutions or in human gastric juice, resulted in the formation of genotoxic derivatives, mainly eliciting base-pair substitutions in his-Salmonella typhimurium and trp- Escherichia coli and inducing an increased lethality in DNA repair-deficient bacteria. Nitrites 25-32 histamine receptor H2 Homo sapiens 42-63 16662897-7 1983 The nitrogenase activity of detached nodules initiated with the nitrate reductase-negative mutant strains was less affected by the KNO(3) treatment as compared to the wild-type strain; however, the results were less conclusive than those obtained with the isolated bacteroids.The addition of either KNO(3) or KNO(2) to detached nodules (wild type) suspended in a semisolid agar nutrient medium caused an inhibition of nitrogenase activity of 50% and 65% as compared to the minus N controls, and provided direct evidence for a localized effect of nitrate and nitrite at the nodule level. Nitrites 558-565 inducible nitrate reductase [NADH] 1 Glycine max 64-81 6137318-1 1983 Glucose-depleted, nitrite-treated opossum erythrocytes effectively reduce methemoglobin in an environment of physiological saline and added glucose does not accelerate the rate of reduction. Nitrites 18-25 hemoglobin subunit gamma 2 Homo sapiens 74-87 6137318-2 1983 In autologous plasma or 25 mM phosphate-buffered saline pH 7.4, added glucose significantly accelerates methemoglobin reduction in glucose-depleted, nitrite-treated opossum erythrocytes. Nitrites 149-156 hemoglobin subunit gamma 2 Homo sapiens 104-117 6326766-4 1983 These data explain the strange temperature dependence of the formation of methemoglobin by nitrite and support the assumption that the short-lived radical is localized on the hemoglobin molecule. Nitrites 91-98 hemoglobin subunit gamma 2 Homo sapiens 74-87 16662415-4 1982 (d) The generation of water-oxidation activity was not affected by the inhibitors of ATP formation and CO(2) fixation, but was inhibited by nitrite, methylviologen and phenylmercuric acetate which suppress or inhibit the reduction of ferredoxin in intact chloroplasts. Nitrites 140-147 ferredoxin-6, chloroplastic Triticum aestivum 234-244 16662475-10 1982 The complete inhibition of FMNH(2)-linked nitrate reductase activity by tungsten in nitrate-grown plants was apparently an artifact caused by the reduction of nitrite by nitrite reductase in the assay system. Nitrites 159-166 chalcone reductase CHR1 Glycine max 50-59 16662475-10 1982 The complete inhibition of FMNH(2)-linked nitrate reductase activity by tungsten in nitrate-grown plants was apparently an artifact caused by the reduction of nitrite by nitrite reductase in the assay system. Nitrites 159-166 chalcone reductase CHR1 Glycine max 178-187 16662417-4 1982 Correlations between nitrate or nitrite concentration in nodules and nodule weight/plant were highly significant.Cytosol from soybean nodules was found to contain NADH-dependent nitrate reductase activity (typical activity was 0.1 micromole per milligram protein x hour). Nitrites 32-39 chalcone reductase CHR1 Glycine max 186-195 6805975-0 1982 Metabolic nitrite formation from N-nitrosamines: evidence for a cytochrome P-450 dependent reaction. Nitrites 10-17 cytochrome P450 family 2 subfamily D member 6 Sus scrofa 64-80 6820251-7 1982 18O studies show that dissociation of nitrite from nitrite reductase can be slow relative to competing reduction or nitrosyl transfer. Nitrites 38-45 nitrite reductase small subunit NirD Pseudomonas stutzeri 51-68 6805975-1 1982 Nitrite was formed on incubation of N-nitrosamines with a reconstituted monooxygenase system, consisting of cytochrome P-450 (P-450) and NADPH P-450 reductase from pig liver. Nitrites 0-7 cytochrome P450 family 2 subfamily D member 6 Sus scrofa 108-124 7046984-3 1982 The present study was undertaken to investigate the effect of adding the concentration of nitrite recommended for the NAP Test (40 mM) to normal fasting human gastric juice. Nitrites 90-97 catenin beta like 1 Homo sapiens 118-121 16661906-3 1981 The nitrate-free in vivo assay system of nitrate reductase was used for measuring the production of nitrite. Nitrites 100-107 chalcone reductase CHR1 Glycine max 49-58 30866360-5 1982 In general, the 40 ppm of nitrite + 0.26% of potassium sorbate cure provided greater bacterial inhibition (especially in fat bacon) than did the nitrite cure. Nitrites 26-33 FAT atypical cadherin 1 Homo sapiens 121-124 7315740-4 1981 It has also been established that the formation of methemoglobin following nitrite administration occurs preferentially under oxygen poor conditions. Nitrites 75-82 hemoglobin subunit gamma 2 Homo sapiens 51-64 6271265-1 1981 Nitrite causes changes in the optical and EPR spectra of cytochrome oxidase from heart and alters the spectral, redox and basic properties of cytochrome c. Nitrites 0-7 cytochrome c, somatic Homo sapiens 142-154 7328862-0 1981 [Studies on the mechanism of methemoglobin formation by nitrite (author"s transl)]. Nitrites 56-63 hemoglobin subunit gamma 2 Homo sapiens 29-42 6272703-6 1981 Since the intermediate haemoglobins such as (alpha 2+ beta 3+)2 and (alpha 3+ beta 2+)2 were found to be produced by the oxidation of haemoglobin by nitrite, the changes in oxyhaemoglobin, intermediate haemoglobins and methaemoglobin during the reaction were followed by isoelectric-focusing electrophoresis. Nitrites 149-156 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 45-63 6270983-3 1981 Methemoglobin formation induced by nitrite was also inhibited by the addition of SOD and catalase. Nitrites 35-42 hemoglobin subunit gamma 2 Homo sapiens 0-13 6270983-3 1981 Methemoglobin formation induced by nitrite was also inhibited by the addition of SOD and catalase. Nitrites 35-42 superoxide dismutase 1 Homo sapiens 81-84 6270983-4 1981 The mechanism of methemoglobin formation by nitrite was discussed in regard to the oxidation of hemoglobin by superoxide and hydrogen peroxide as generated by the interaction of nitrite with hemoglobin. Nitrites 44-51 hemoglobin subunit gamma 2 Homo sapiens 17-30 6270983-4 1981 The mechanism of methemoglobin formation by nitrite was discussed in regard to the oxidation of hemoglobin by superoxide and hydrogen peroxide as generated by the interaction of nitrite with hemoglobin. Nitrites 178-185 hemoglobin subunit gamma 2 Homo sapiens 17-30 6272703-6 1981 Since the intermediate haemoglobins such as (alpha 2+ beta 3+)2 and (alpha 3+ beta 2+)2 were found to be produced by the oxidation of haemoglobin by nitrite, the changes in oxyhaemoglobin, intermediate haemoglobins and methaemoglobin during the reaction were followed by isoelectric-focusing electrophoresis. Nitrites 149-156 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 69-87 7470659-0 1980 Low erythrocyte glucose-6-phosphate dehydrogenase (g-6-PD) activity and susceptibility to nitrite-induced methemoglobin formation. Nitrites 90-97 glucose-6-phosphate dehydrogenase Homo sapiens 51-57 7470659-0 1980 Low erythrocyte glucose-6-phosphate dehydrogenase (g-6-PD) activity and susceptibility to nitrite-induced methemoglobin formation. Nitrites 90-97 hemoglobin subunit gamma 2 Homo sapiens 106-119 7020546-2 1980 In the NO3/NO2 couple, it is accepted that especially nitrite ion lays down a toxicological problem, probably because of its particular chemical reactivity: nitrite ion, which is the base of nitrous acid HNO2 (pKa = 3.36) can react with many functional groups from dietary or endogenous origin; it is also a reducing agent, only oxidable by chemical oxidants or adequate enzyme systems; at the same time it is an oxidant for many reduced substrates. Nitrites 54-61 NBL1, DAN family BMP antagonist Homo sapiens 7-10 16661493-6 1980 Through the use of a variety of electron donors and acceptors, the lack of nitrate reductase activity in NR1 cells was shown to be due to the absence of, or a defect in, that component of the enzyme which mediates the reduction of nitrate to nitrite.In other experiments, DI-6 and NR1 were grown on a solid medium containing casein hydrolysate (2 grams liter(-1)) as the sole N source. Nitrites 242-249 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 105-108 7356567-7 1980 Methemoglobin forms during diazotization because of reactions of oxyhemoglobin with both diazo reagent and nitrite ion. Nitrites 107-114 hemoglobin subunit gamma 2 Homo sapiens 0-13 6253458-6 1980 Conversion of hemoglobin to methemoglobin by nitrite treatment did not impair neutrophil-mediated hemolysis. Nitrites 45-52 hemoglobin subunit gamma 2 Homo sapiens 28-41 6253458-8 1980 H2O2 and methemoglobin are known to interact to form an oxidant complex whose cytotoxic potential was underlined by the marked sensitivity of nitrite-treated cells to commercial H2O2. Nitrites 142-149 hemoglobin subunit gamma 2 Homo sapiens 9-22 7350910-7 1980 Added hydroxylamine was cooxidized to nitrite in an amount equimolar with the HCN formed. Nitrites 38-45 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 78-81 7020546-2 1980 In the NO3/NO2 couple, it is accepted that especially nitrite ion lays down a toxicological problem, probably because of its particular chemical reactivity: nitrite ion, which is the base of nitrous acid HNO2 (pKa = 3.36) can react with many functional groups from dietary or endogenous origin; it is also a reducing agent, only oxidable by chemical oxidants or adequate enzyme systems; at the same time it is an oxidant for many reduced substrates. Nitrites 157-164 NBL1, DAN family BMP antagonist Homo sapiens 7-10 436113-1 1979 N6(Methylnitroso) adenosine (M6(NO)Ado) is found readily under acidic conditions by the interaction of nitrite with 6-methyladenosine, a naturally-occurring nucleoside. Nitrites 103-110 homeobox A7 Mus musculus 29-38 41590-1 1979 During the reaction of oxyhemoglobin (HbO2) with nitrite, the concentration of residual nitrite, nitrate, oxygen, and methemoglobin (Hb+) was determined successively. Nitrites 49-56 hemoglobin subunit gamma 2 Homo sapiens 118-131 7228251-1 1980 Several naturally occurring amino compounds, structurally related to pyrrolidine, were reacted with nitrite in heated, weakly acidic, aqueous systems and the amount of NPYR formed was measured. Nitrites 100-107 neuropeptide Y receptor Y1 Homo sapiens 168-172 7228251-3 1980 The yields of NPYR formed from pyrrolidine, putrescine, agmatine, spermidine, spermine, proline, ornithine and arginine with nitrite in the pH range 6.6 to 4.0 were determined. Nitrites 125-132 neuropeptide Y receptor Y1 Homo sapiens 14-18 499422-2 1979 Its effect seems to be due to its action in reducing methemoglobin formed by nitrite. Nitrites 77-84 hemoglobin subunit gamma 2 Homo sapiens 53-66 216667-0 1978 Reaction of cytochrome c with nitrite and nitric oxide. Nitrites 30-37 LOC104968582 Bos taurus 12-24 216667-16 1978 A model system for dissimilatory nitrite reductase was constructed by using bovine heart cytochrome c, nitrite and NADH plus PMS at pH 3.3, and a scheme involving cyclic turnover of ferrocytochrome c, Compound I and Compound II is presented, with kinetic parameters. Nitrites 33-40 LOC104968582 Bos taurus 89-101 676343-0 1978 Effect of nitrite on microsomal cytochrome P-450. Nitrites 10-17 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 32-48 676343-2 1978 Addition of nitrite to anaerobic rat liver microsomes leads to the appearance of a difference spectrum similar to the spectrum of the ferrous cytochrome P-450-NO complex. Nitrites 12-19 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 142-158 676343-8 1978 A similar spectrum can be obtained by addition of nitrite to urea-treated microsomes in which cytochrome P-450 has been converted to cytochrome P-420. Nitrites 50-57 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 94-110 676343-12 1978 It is concluded that in anaerobic microsomes, NO formed from nitrite complexes with ferrous cytochrome P-450 and thereby inhibits reductive drug metabolism. Nitrites 61-68 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 92-108 12468-0 1976 Formation of mutagenic N-nitroso compounds from the pesticides prometryne, dodine and carbaryl in the presence of nitrite at pH 1. Nitrites 114-121 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 125-129 560873-0 1977 Effect of nitrite upon leghemoglobin and interaction with nitrogen fixation. Nitrites 10-17 leghemoglobin A Glycine max 23-36 560873-2 1977 In the presence of leghemoglobin (0.1mM), a 3-fold enhancement of nitrogen fixation occurred but the inhibitory effect of nitrite was delayed. Nitrites 122-129 leghemoglobin A Glycine max 19-32 560873-3 1977 Spectra of leghemoglobin showed a rapid disappearance of the 574 nm and 541 nm peaks of oxyleghemoglobin the presence of nitrite. Nitrites 121-128 leghemoglobin A Glycine max 11-24 560873-5 1977 High nitrite levels could depress nitrogen fixation both by inactivation of nitrogenase and by conversion of leghemoglobin into an inactive form. Nitrites 5-12 leghemoglobin A Glycine max 109-122 16079-4 1977 Although activities of GS and GDH were low in two mutants that are unable to synthesize cytochrome c552 or reduce nitrite because of defects in the nirA gene, the nirA defect was separated from the GS and GDH defects by transduction with bacteriophage P1. Nitrites 114-121 glutamate dehydrogenase Escherichia coli 30-33 11898-0 1976 A mechanism for the conversion of oxyhemoglobin to methemoglobin by nitrite. Nitrites 68-75 hemoglobin subunit gamma 2 Homo sapiens 51-64 11898-1 1976 Each mole of oxyhemoglobin iron converted to methemoglobin causes the oxidation of 1.5 mol of nitrite to nitrate and consumes 1 mol of protons. Nitrites 94-101 hemoglobin subunit gamma 2 Homo sapiens 45-58 1033914-1 1976 Higher levels of NPy and NDMA in cooked bacon and its cooked-out fat were associated with those cures which contained higher levels of nitrite, but no correlation between nitrosamine concentrations and initial nitrate levels was observed. Nitrites 135-142 neuropeptide Y Homo sapiens 17-20 16659553-3 1976 One of the hydroxylamine reductases found only in small amounts is associated with nitrite reductase and is induced, together with nitrite reductase, by nitrite. Nitrites 83-90 ferredoxin--nitrite reductase, chloroplastic Zea mays 131-148 16659553-4 1976 The other two enzymes are noninducible by nitrite and can be totally separated from nitrite reductase, which subsequently remains capable of catalyzing the reduction of nitrite to ammonia. Nitrites 42-49 ferredoxin--nitrite reductase, chloroplastic Zea mays 84-101 187094-4 1976 The nitrite-induced methemoglobin, by competitively binding the toxic hydrosulfide anion until detoxified, presumably reactivated and protected cytochrome oxidase and therby aided the patient"s recovery by enhancing aerobic metabolism. Nitrites 4-11 hemoglobin subunit gamma 2 Homo sapiens 20-33 1194276-3 1975 The oxygen-binding function of myoglobin, in situ in muscle fiber bundles, was abolished by treatment with nitrite of hydroxylamine, which convert oxymyoglobin in situ to high spin ferric myoglobin, or with phenylhydrazine, which converts oxymyoglobin to denatured products, or with 2-hydroxyethylhydrazine, which appears to remove myoglobin from the muslce. Nitrites 107-114 myoglobin Homo sapiens 31-40 4599799-0 1974 Nitrite-induced inhibition of purified fractions of chicken muscle cathepsin D. Nitrites 0-7 cathepsin D Gallus gallus 67-78 1194276-3 1975 The oxygen-binding function of myoglobin, in situ in muscle fiber bundles, was abolished by treatment with nitrite of hydroxylamine, which convert oxymyoglobin in situ to high spin ferric myoglobin, or with phenylhydrazine, which converts oxymyoglobin to denatured products, or with 2-hydroxyethylhydrazine, which appears to remove myoglobin from the muslce. Nitrites 107-114 myoglobin Homo sapiens 150-159 1194276-3 1975 The oxygen-binding function of myoglobin, in situ in muscle fiber bundles, was abolished by treatment with nitrite of hydroxylamine, which convert oxymyoglobin in situ to high spin ferric myoglobin, or with phenylhydrazine, which converts oxymyoglobin to denatured products, or with 2-hydroxyethylhydrazine, which appears to remove myoglobin from the muslce. Nitrites 107-114 myoglobin Homo sapiens 150-159 1213205-1 1975 In acute experiments on dogs, a negative correlation between arterial pressure and the blood renin activity was shown during hemodynamic shifts following occlusion of the carotid arteries or v. cava anterior, as well as ephedrinum or nitrite of sodium administration. Nitrites 234-241 renin Canis lupus familiaris 93-98 16742412-11 1966 Nitrite reductase is induced by nitrite and only indirectly by nitrate. Nitrites 32-39 ferredoxin--nitrite reductase, chloroplastic Raphanus sativus 0-17 4869972-1 1967 V. Nitrite-dependent gas evolution in cells containing cytochrome c-552. Nitrites 3-10 cytochrome c, somatic Homo sapiens 55-67 5499448-0 1970 Evidence for an irreversible reaction between nitrite and human methemoglobin. Nitrites 46-53 hemoglobin subunit gamma 2 Homo sapiens 64-77 6053210-0 1967 The nitrite methemoglobin complex--its significance in methemoglobin analyses and its possible role in methemoglobinemia. Nitrites 4-11 hemoglobin subunit gamma 2 Homo sapiens 12-25 6053210-0 1967 The nitrite methemoglobin complex--its significance in methemoglobin analyses and its possible role in methemoglobinemia. Nitrites 4-11 hemoglobin subunit gamma 2 Homo sapiens 55-68 4860848-2 1966 Possible involvement of cytochrome c-552 in anaerobic nitrite metabolism. Nitrites 54-61 cytochrome c, somatic Homo sapiens 24-36 13777923-0 1960 [The behavior of nitrite inactivated T-1 phages in crossing and multiplicity reactivation tests]. Nitrites 17-24 CD5 molecule Homo sapiens 37-40 33524692-2 2021 The mechanisms involved in NOC formation are studied in regard with the dose-response relationship of added nitrite and its interaction with ascorbate on NOC formation in a cured and cooked meat model. Nitrites 108-115 nocturnin Homo sapiens 27-30 14406565-0 1959 Methemoglobin reduction rate of nitrite treated red cells as a function of cell age. Nitrites 32-39 hemoglobin subunit gamma 2 Homo sapiens 0-13 33839658-5 2021 Spectral changes upon nitrite adsorption imply an inner-sphere surface interaction (monodentate and bidentate) at pH 5.5 based on ATR-FTIR spectra of the nitrite-goethite interface over time. Nitrites 22-29 ATR serine/threonine kinase Homo sapiens 130-133 33524692-2 2021 The mechanisms involved in NOC formation are studied in regard with the dose-response relationship of added nitrite and its interaction with ascorbate on NOC formation in a cured and cooked meat model. Nitrites 108-115 nocturnin Homo sapiens 154-157 33410970-7 2021 RESULTS: We found that patients carrying the AG + GG genotypes for the rs3742879 polymorphism in ARG2 gene and the ARG2 GC haplotype show lower increases in nitrite levels and lower decreases in blood pressure after propofol anesthesia. Nitrites 157-164 arginase 2 Homo sapiens 97-101 33410970-7 2021 RESULTS: We found that patients carrying the AG + GG genotypes for the rs3742879 polymorphism in ARG2 gene and the ARG2 GC haplotype show lower increases in nitrite levels and lower decreases in blood pressure after propofol anesthesia. Nitrites 157-164 arginase 2 Homo sapiens 115-119 33410970-8 2021 On the other hand, subjects carrying the variant genotypes for the rs10483801 polymorphism in ARG2 gene show more intense decreases in blood pressure (CA genotype) and/or higher increases in nitrite levels (CA and AA genotypes) in response to propofol. Nitrites 191-198 arginase 2 Homo sapiens 94-98 34022899-20 2021 instillation induced less total cells in the BALF and nitrite production in the serum of JNK1-/- mice than those of WT mice. Nitrites 54-61 mitogen-activated protein kinase 8 Mus musculus 89-93 34018850-8 2021 Intravenous nitrite infusion induced greater effects, with significant decreases in LVEDP, EDPVR, LVEST, LV dP/dtmin, tau, and mean arterial pressure. Nitrites 12-19 microtubule associated protein tau Homo sapiens 118-121 33987886-3 2021 METHODS: A multistep nitrite-coated filter-pack system is newly adopted to transfer the O-atoms in terminal positions of O3 to nitrite on each filter to determine Delta17 O of O3 in terminal positions (denoted as Delta17 O(O3 )term ). Nitrites 21-28 immunoglobulin kappa variable 2D-38 (pseudogene) Homo sapiens 220-225 33987886-5 2021 RESULTS: The reciprocal of the NO3 - quantities on the nitrite-coated filters in each sample showed a strong linear relationship with Delta17 O of NO3 - . Nitrites 55-62 NBL1, DAN family BMP antagonist Homo sapiens 31-34 33987886-5 2021 RESULTS: The reciprocal of the NO3 - quantities on the nitrite-coated filters in each sample showed a strong linear relationship with Delta17 O of NO3 - . Nitrites 55-62 NBL1, DAN family BMP antagonist Homo sapiens 147-150 33657463-3 2021 During the activation of FPR2 induced by its agonist AGP-8694, a high level of Brucella uptake was accompanied by an increase in ERK phosphorylation, while intracellular survival at 24 h postincubation was observed to be associated with slightly reduced nitrite accumulation but augmented superoxide anion production. Nitrites 254-261 formyl peptide receptor 2 Mus musculus 25-29 33961276-11 2021 This intoxication case informs some novel points about nitrite intoxication; the concentration of methemoglobin decreased during the PM period, while the concentration of nitrate was stable. Nitrites 55-62 hemoglobin subunit gamma 2 Homo sapiens 98-111 33578127-2 2021 The main XOR activities are: (i) xanthine dehydrogenase (XDH) activity that performs the last two steps of purine catabolism, from hypoxanthine to uric acid; (ii) xanthine oxidase (XO) activity that, besides purine catabolism, produces reactive oxygen species (ROS); (iii) nitrite reductase activity that generates nitric oxide, contributing to vasodilation and regulation of blood pressure; (iv) NADH oxidase activity that produces ROS. Nitrites 273-280 xanthine dehydrogenase Homo sapiens 9-12 33676021-4 2021 Here, we compared the alleles and genotypes of single nucleotide polymorphisms (SNPs) in ARG1 (rs2781659; rs2781667; rs2246012; rs17599586) and ARG2 (rs3742879; rs10483801) in healthy pregnant women and preeclampsia, and examined whether these SNPs affect plasma nitrite concentrations (a marker of NO formation) in these groups. Nitrites 263-270 arginase 1 Homo sapiens 89-93 33676021-9 2021 CONCLUSIONS: Our results suggest that SNPs of ARG1 increase the risk of preeclampsia and modulate plasma nitrite levels in healthy pregnant women. Nitrites 105-112 arginase 1 Homo sapiens 46-50 33713800-3 2021 We showed that at conditions of increased NO need, this nitrate reservoir is used in situ to generate nitrite and NO, at least in part via the nitrate reductase activity of xanthine oxidoreductase (XOR). Nitrites 102-109 xanthine dehydrogenase Rattus norvegicus 173-196 33713800-3 2021 We showed that at conditions of increased NO need, this nitrate reservoir is used in situ to generate nitrite and NO, at least in part via the nitrate reductase activity of xanthine oxidoreductase (XOR). Nitrites 102-109 xanthine dehydrogenase Rattus norvegicus 198-201 33713800-8 2021 During the course of the overall experiment there was a gradual increase of XOR expression in muscle tissue, which likely led to enhanced nitrate to nitrite reduction. Nitrites 149-156 xanthine dehydrogenase Rattus norvegicus 76-79 33578127-2 2021 The main XOR activities are: (i) xanthine dehydrogenase (XDH) activity that performs the last two steps of purine catabolism, from hypoxanthine to uric acid; (ii) xanthine oxidase (XO) activity that, besides purine catabolism, produces reactive oxygen species (ROS); (iii) nitrite reductase activity that generates nitric oxide, contributing to vasodilation and regulation of blood pressure; (iv) NADH oxidase activity that produces ROS. Nitrites 273-280 xanthine dehydrogenase Homo sapiens 33-55 33578127-2 2021 The main XOR activities are: (i) xanthine dehydrogenase (XDH) activity that performs the last two steps of purine catabolism, from hypoxanthine to uric acid; (ii) xanthine oxidase (XO) activity that, besides purine catabolism, produces reactive oxygen species (ROS); (iii) nitrite reductase activity that generates nitric oxide, contributing to vasodilation and regulation of blood pressure; (iv) NADH oxidase activity that produces ROS. Nitrites 273-280 xanthine dehydrogenase Homo sapiens 57-60 33849366-9 2021 CONCLUSIONS: Water, heat, and excipients" nitrite and nitrate levels are the key players, which should collectively exist, to cause NDMA formation during MET tablets manufacturing. Nitrites 42-49 SAFB like transcription modulator Homo sapiens 154-157 33063115-10 2021 It was shown to act as a novel agent to reduce nitrite induced metHb formation in a dose dependent manner. Nitrites 47-54 hemoglobin subunit gamma 2 Homo sapiens 63-68 33916572-9 2021 Further, phosphorylation of ERK1/2 was increased after treatment with both acidified nitrite and indirect CAP. Nitrites 85-92 mitogen-activated protein kinase 3 Homo sapiens 28-34 33450066-10 2021 In contrast, inhibition of ALDH2 by benomyl (10 muM) inhibited NTG-induced nitrite production and relaxation and deletion of POR did not modulate this response. Nitrites 75-82 aldehyde dehydrogenase 2, mitochondrial Mus musculus 27-32 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrites 281-288 complement C2 Homo sapiens 62-65 33450066-5 2021 KEY RESULTS: Using microsomes containing recombinant CYPs expressed in human vascular tissues, we show that nitrite is released from NTG and PETN with CYP2C9 and CYP2C8 being most efficient. Nitrites 108-115 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 151-157 33450066-5 2021 KEY RESULTS: Using microsomes containing recombinant CYPs expressed in human vascular tissues, we show that nitrite is released from NTG and PETN with CYP2C9 and CYP2C8 being most efficient. Nitrites 108-115 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 162-168 33168291-2 2021 The reduction efficiency, products and mechanism of nitrate or nitrite by CO2- radical were investigated based on the results of batch experiments and theoretical calculation using density functional theory (DFT) methods, respectively. Nitrites 63-70 complement C2 Homo sapiens 74-77 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrites 281-288 complement C2 Homo sapiens 221-224 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrites 127-134 complement C2 Homo sapiens 62-65 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrites 127-134 complement C2 Homo sapiens 221-224 33168291-5 2021 Specifically, nitrate was firstly reduced into nitrite with the assistance of Zn/Ag bimetal, and then nitrite was further reduced into N2 by CO2- radical. Nitrites 102-109 complement C2 Homo sapiens 141-144 33544107-4 2021 The present study demonstrates that NAC-SNO under the same conditions and concentrations, in meat products, acts as an anti-clostridial compound similar to nitrite. Nitrites 156-163 NLR family, pyrin domain containing 1A Mus musculus 36-39 33115598-1 2021 BACKGROUND: Vitamin C may enhance nitric oxide (NO) production through stepwise reduction of dietary nitrate (NO3) to nitrite (NO2) to NO. Nitrites 118-125 NBL1, DAN family BMP antagonist Homo sapiens 110-113 33352382-0 2021 Nitrate and nitrite bacterial reduction at alkaline pH and high nitrate concentrations, comparison of acetate versus dihydrogen as electron donors. Nitrites 12-19 phenylalanine hydroxylase Homo sapiens 52-54 32916405-2 2021 Herein, a carbon selenide nanofilms modified carbon fiber cloth (CSe2 NF/CC) electrode was obtained via in-situ synthesis to detect nitrite. Nitrites 132-139 neurofascin Homo sapiens 70-72 32916405-5 2021 Additionally, the CSe2 NF/CC was successfully used for nitrite detection in different food samples such as pickled vegetables and sausage samples. Nitrites 55-62 neurofascin Homo sapiens 23-25 33790801-0 2021 NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women. Nitrites 90-97 nitric oxide synthase 3 Homo sapiens 0-4 33790801-3 2021 It analyzed the influence of NOS3 polymorphisms [-786T > C, 894G > T (Glu298Asp), and intron 4b/a] on the response of blood pressure (BP), nitrite concentration, and physical fitness in older adult women. Nitrites 139-146 nitric oxide synthase 3 Homo sapiens 29-33 33649977-9 2021 In addition, vit D elevated thiol content, SOD and CAT activities, and BDNF levels, while reduced nitrite and MDA concentration. Nitrites 98-105 vitrin Rattus norvegicus 13-16 33594566-1 2021 AD2 for efficient nitrate reduction without nitrite accumulation. Nitrites 44-51 apolipoprotein E Homo sapiens 0-3 33594566-6 2021 Results showed that strain AD2 removed 98.9% of nitrate-nitrogen (NO3--N) with an initial concentration about 100 mg L-1 in 48 h without nitrite-nitrogen (NO2--N) accumulation. Nitrites 137-144 apolipoprotein E Homo sapiens 27-30 33352382-3 2021 With both types of electron donors, nitrite reduction was the key step, likely to increase the pH and lead to nitrite accumulation. Nitrites 36-43 phenylalanine hydroxylase Homo sapiens 95-97 33352529-3 2021 For a long time it was assumed that hydroxylamine was directly converted to nitrite by a hydroxylamine oxidoreductase. Nitrites 76-83 thioredoxin reductase 1 Homo sapiens 103-117 33161133-4 2021 Nitrite supplementation in H9c2 myoblasts under high glucose diminishes the Bcl-xL expression and mitochondrial ROS levels without significant initiation of cell death or decline in total ROS levels. Nitrites 0-7 BCL2 like 1 Homo sapiens 76-82 33161133-6 2021 The study also revealed that under high glucose stress, nitrite may alter mitochondrial dynamics by Drp1 activation possibly via Akt1-Pim1 axis. Nitrites 56-63 utrophin Homo sapiens 100-104 33161133-6 2021 The study also revealed that under high glucose stress, nitrite may alter mitochondrial dynamics by Drp1 activation possibly via Akt1-Pim1 axis. Nitrites 56-63 AKT serine/threonine kinase 1 Homo sapiens 129-133 33161133-6 2021 The study also revealed that under high glucose stress, nitrite may alter mitochondrial dynamics by Drp1 activation possibly via Akt1-Pim1 axis. Nitrites 56-63 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 134-138 33486594-12 2021 MMIF as a pro-inflammatory mediator can cause increased susceptibility to glutamate-related neurotoxicity, increased nitrite production, increased ERK activation, and increased COX2/PGE2 signaling pathway activation and subsequent stimulation of CCL5-related chemotaxis. Nitrites 117-124 macrophage migration inhibitory factor Homo sapiens 0-4 33319981-0 2021 CdS/TiO2 Nanocomposite-Based Photoelectrochemical Sensor for a Sensitive Determination of Nitrite in Principle of Etching Reaction. Nitrites 90-97 CDP-diacylglycerol synthase 1 Homo sapiens 0-3 33170181-0 2021 Quantitative response to nitrite from field-induced decomposition of the chloride adduct of RDX by reactive stage tandem ion mobility spectrometry. Nitrites 25-32 radixin Homo sapiens 92-95 33170181-4 2021 A nitrite peak with S/N of 8.5 was observed with vapour concentrations of 54 ppb for RDX and 329 ppb for Interferent A in the ionization volume corresponding to 2 ng of RDX and 100 ng of Interferent A deposited on sample traps in the thermal desorption inlet. Nitrites 2-9 radixin Homo sapiens 85-88 33170181-4 2021 A nitrite peak with S/N of 8.5 was observed with vapour concentrations of 54 ppb for RDX and 329 ppb for Interferent A in the ionization volume corresponding to 2 ng of RDX and 100 ng of Interferent A deposited on sample traps in the thermal desorption inlet. Nitrites 2-9 radixin Homo sapiens 169-172 33319981-2 2021 The CdS etching process caused by nitrite-in-acid solution was confirmed and applied to nitrite sensing. Nitrites 34-41 CDP-diacylglycerol synthase 1 Homo sapiens 4-7 33319981-1 2021 The CdS/TiO2 nanocomposite (NC) photoelectrochemical (PEC) sensor was constructed based on a new sensing strategy for nitrite assay. Nitrites 118-125 CDP-diacylglycerol synthase 1 Homo sapiens 4-7 33126056-0 2021 Oral nitrite treatment increases S-nitrosylation of vascular protein kinase C and attenuates the responses to angiotensin II. Nitrites 5-12 proline rich transmembrane protein 2 Homo sapiens 61-77 33319981-3 2021 The CdS etching phenomenon occurring on the sensor led to an obvious reduction in the photocurrent response under visible-light irradiation, which responded to the nitrite concentration. Nitrites 164-171 CDP-diacylglycerol synthase 1 Homo sapiens 4-7 33319981-4 2021 The CdS/TiO2 NC-based PEC sensor exhibited excellent performance on nitrite detection. Nitrites 68-75 CDP-diacylglycerol synthase 1 Homo sapiens 4-7 33319981-5 2021 The linear range for nitrite determination was from 1-100 and 100-500 muM, and the sensitivity of the PEC sensor was 2.91 and 0.186 muA muM-1 cm-2, respectively. Nitrites 21-28 PWWP domain containing 3A, DNA repair factor Homo sapiens 136-141 33212150-9 2021 Compared to T2D + nitrite, co-administration of nitrite and NaSH resulted in significant increases in mRNA expression of PI3K, Akt, and eNOS and significant decreases in mRNA expression of G6Pase and FBPase but had no effect on PEPCK expression. Nitrites 48-55 AKT serine/threonine kinase 1 Rattus norvegicus 127-130 33212150-9 2021 Compared to T2D + nitrite, co-administration of nitrite and NaSH resulted in significant increases in mRNA expression of PI3K, Akt, and eNOS and significant decreases in mRNA expression of G6Pase and FBPase but had no effect on PEPCK expression. Nitrites 48-55 nitric oxide synthase 3 Rattus norvegicus 136-140 33212150-9 2021 Compared to T2D + nitrite, co-administration of nitrite and NaSH resulted in significant increases in mRNA expression of PI3K, Akt, and eNOS and significant decreases in mRNA expression of G6Pase and FBPase but had no effect on PEPCK expression. Nitrites 48-55 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 189-195 33212150-9 2021 Compared to T2D + nitrite, co-administration of nitrite and NaSH resulted in significant increases in mRNA expression of PI3K, Akt, and eNOS and significant decreases in mRNA expression of G6Pase and FBPase but had no effect on PEPCK expression. Nitrites 48-55 fructose-bisphosphatase 2 Rattus norvegicus 200-206 33212150-9 2021 Compared to T2D + nitrite, co-administration of nitrite and NaSH resulted in significant increases in mRNA expression of PI3K, Akt, and eNOS and significant decreases in mRNA expression of G6Pase and FBPase but had no effect on PEPCK expression. Nitrites 48-55 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 228-233 33212150-11 2021 This inhibitory effect of nitrite and NaSH co-administration on gluconeogenesis were associated with increased gene expression of PI3K, Akt, and eNOS in the liver. Nitrites 26-33 AKT serine/threonine kinase 1 Rattus norvegicus 136-139 33212150-11 2021 This inhibitory effect of nitrite and NaSH co-administration on gluconeogenesis were associated with increased gene expression of PI3K, Akt, and eNOS in the liver. Nitrites 26-33 nitric oxide synthase 3 Rattus norvegicus 145-149 33126056-4 2021 Our results show that oral nitrite treatment enhances circulating RXNO concentrations (measured by ozone-based chemiluminescence methods), increases aortic protein kinase C (PKC) nitrosylation (measured by resin-assisted capture SNO-RAC method), and reduces both angiotensin II-induced vasoconstriction (isolated aortic ring preparation) and hypertensive (in vivo invasive blood pressure measurements) effects implicating PKC nitrosylation as a key mechanism for the responses to oral nitrite. Nitrites 27-34 proline rich transmembrane protein 2 Homo sapiens 156-172 33126056-4 2021 Our results show that oral nitrite treatment enhances circulating RXNO concentrations (measured by ozone-based chemiluminescence methods), increases aortic protein kinase C (PKC) nitrosylation (measured by resin-assisted capture SNO-RAC method), and reduces both angiotensin II-induced vasoconstriction (isolated aortic ring preparation) and hypertensive (in vivo invasive blood pressure measurements) effects implicating PKC nitrosylation as a key mechanism for the responses to oral nitrite. Nitrites 27-34 proline rich transmembrane protein 2 Homo sapiens 174-177 33126056-4 2021 Our results show that oral nitrite treatment enhances circulating RXNO concentrations (measured by ozone-based chemiluminescence methods), increases aortic protein kinase C (PKC) nitrosylation (measured by resin-assisted capture SNO-RAC method), and reduces both angiotensin II-induced vasoconstriction (isolated aortic ring preparation) and hypertensive (in vivo invasive blood pressure measurements) effects implicating PKC nitrosylation as a key mechanism for the responses to oral nitrite. Nitrites 27-34 angiotensinogen Homo sapiens 263-277 33126056-4 2021 Our results show that oral nitrite treatment enhances circulating RXNO concentrations (measured by ozone-based chemiluminescence methods), increases aortic protein kinase C (PKC) nitrosylation (measured by resin-assisted capture SNO-RAC method), and reduces both angiotensin II-induced vasoconstriction (isolated aortic ring preparation) and hypertensive (in vivo invasive blood pressure measurements) effects implicating PKC nitrosylation as a key mechanism for the responses to oral nitrite. Nitrites 27-34 proline rich transmembrane protein 2 Homo sapiens 422-425 33126056-9 2021 Together, these results are consistent with the idea that PKC nitrosylation in the vasculature may underlie oral nitrite treatment-induced reduction in the vascular and hypertensive responses to angiotensin II. Nitrites 113-120 proline rich transmembrane protein 2 Homo sapiens 58-61 33126056-9 2021 Together, these results are consistent with the idea that PKC nitrosylation in the vasculature may underlie oral nitrite treatment-induced reduction in the vascular and hypertensive responses to angiotensin II. Nitrites 113-120 angiotensinogen Homo sapiens 195-209 33126056-0 2021 Oral nitrite treatment increases S-nitrosylation of vascular protein kinase C and attenuates the responses to angiotensin II. Nitrites 5-12 angiotensinogen Homo sapiens 110-124 33226391-1 2020 This work demonstrated the development of conducting poly(chrysoidine G) (PCG)-gold nanoparticle (AuNP)-modified fluorine-doped tin oxide (F : SnO2, FTO) film-coated glass electrodes for the sensitive electrochemical detection of nitrite (NO2-). Nitrites 230-237 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 149-152 33206969-6 2020 By constructing a mutant strain defective for napA, we demonstrated that the reduction of nitrate to nitrite was catalyzed by the periplasmic nitrate reductase, NapA. Nitrites 101-108 periplasmic nitrate reductase subunit alpha Agrobacterium fabrum str. C58 46-50 33206969-6 2020 By constructing a mutant strain defective for napA, we demonstrated that the reduction of nitrate to nitrite was catalyzed by the periplasmic nitrate reductase, NapA. Nitrites 101-108 periplasmic nitrate reductase subunit alpha Agrobacterium fabrum str. C58 161-165 32816364-7 2020 By integrating redox-active property of metalloporphyrinic MOFs and high conductivity of CFP, MOF thin films on CFP provided a significantly improvement of electrocatalytic performance to detoxify the carcinogenic nitrite with good stability. Nitrites 214-221 lysine acetyltransferase 8 Homo sapiens 59-62 33166836-4 2020 Using quantification of nitrite levels, RT-PCR analysis and RNA interference we demonstrate that adenosine A1 (A1R) and A2a receptor (A2aR) agonists induce a concentration-dependent decrease and increase of nitrite and nNOS mRNA levels in cultured cells from WKY and SHR, respectively. Nitrites 24-31 adenosine A2a receptor Rattus norvegicus 120-132 33166836-4 2020 Using quantification of nitrite levels, RT-PCR analysis and RNA interference we demonstrate that adenosine A1 (A1R) and A2a receptor (A2aR) agonists induce a concentration-dependent decrease and increase of nitrite and nNOS mRNA levels in cultured cells from WKY and SHR, respectively. Nitrites 24-31 adenosine A2a receptor Rattus norvegicus 134-138 14229676-0 1964 THE FORMATION OF GREEN HEME PIGMENTS FROM METMYOGLOBIN AND METHEMOGLOBIN BY THE ACTION OF NITRITE. Nitrites 90-97 hemoglobin subunit gamma 2 Homo sapiens 59-72 32854085-6 2020 Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved. Nitrites 58-65 L1 cell adhesion molecule Homo sapiens 50-53 33011197-10 2020 Increase in Iba-1 protein and nitrite levels after Abeta (1-42) administrationwere partially attenuated by salubrinal. Nitrites 30-37 amyloid beta precursor protein Rattus norvegicus 51-56 33070664-11 2020 Both Ang (1-7) and olmesartan increased eNOS expression and plasma nitrite which were reduced by A-779. Nitrites 67-74 angiogenin Rattus norvegicus 5-13 33166836-4 2020 Using quantification of nitrite levels, RT-PCR analysis and RNA interference we demonstrate that adenosine A1 (A1R) and A2a receptor (A2aR) agonists induce a concentration-dependent decrease and increase of nitrite and nNOS mRNA levels in cultured cells from WKY and SHR, respectively. Nitrites 207-214 adenosine A2a receptor Rattus norvegicus 120-132 33005412-7 2020 Higher concentrations of IL-6, TNF-alpha, IL-1beta, nitrite ( NO 2 - ) and nitrate ( NO 3 - ) and a lower concentration of IL-10 were observed in CD163-deficient mice treated with LPS. Nitrites 52-59 CD163 antigen Mus musculus 148-153 33166836-4 2020 Using quantification of nitrite levels, RT-PCR analysis and RNA interference we demonstrate that adenosine A1 (A1R) and A2a receptor (A2aR) agonists induce a concentration-dependent decrease and increase of nitrite and nNOS mRNA levels in cultured cells from WKY and SHR, respectively. Nitrites 207-214 adenosine A2a receptor Rattus norvegicus 134-138 33166836-5 2020 These effects in nitrite levels are attenuated by the administration of A1R and A2aR selective antagonists, CPT and ZM 241385. Nitrites 17-24 adenosine A2a receptor Rattus norvegicus 80-84 33166836-8 2020 Finally, it is shown that the cAMP-PKA pathway is involved in A1R and A2aR-mediated decrease and increase in nitrite levels in SHR and WKY cells. Nitrites 109-116 adenosine A2a receptor Rattus norvegicus 70-74 33213070-11 2020 The patients that received Vit C had decreased levels of the nitrate and nitrite ratio (p < 0.01) and C-reactive protein levels (p = 0.04). Nitrites 73-80 vitrin Homo sapiens 27-30 32141427-5 2020 Using a loss-of-function assay and inhibitor treatment, we found that AGT knockdown inhibited the increase of IL-1beta, matrix metalloproteinase (MMP)-13 and nitrite in IL-6-induced chondrocytes through blocking the renin-angiotensin system (RAS). Nitrites 158-165 angiotensinogen Homo sapiens 70-73 32141427-5 2020 Using a loss-of-function assay and inhibitor treatment, we found that AGT knockdown inhibited the increase of IL-1beta, matrix metalloproteinase (MMP)-13 and nitrite in IL-6-induced chondrocytes through blocking the renin-angiotensin system (RAS). Nitrites 158-165 interleukin 6 Homo sapiens 169-173 32891753-0 2020 Myoglobin promotes nitrite-dependent mitochondrial S-NITROSATION to mediate cytoprotection after hypoxia/reoxygenation. Nitrites 19-26 myoglobin Homo sapiens 0-9 32891753-3 2020 Nitrite, an endogenous signaling molecule and dietary constituent, mediates potent cardioprotection after I/R and this effect relies on its interaction with both myoglobin and mitochondria. Nitrites 0-7 myoglobin Homo sapiens 162-171 32891753-4 2020 While independent mechanistic studies have demonstrated that nitrite-mediated cardioprotection requires the presence of myoglobin and the post-translational S-nitrosation of critical cysteine residues on mitochondrial complex I, it is unclear whether myoglobin directly catalyzes the S-nitrosation of complex I or whether mitochondrial-dependent nitrite reductase activity contributes to S-nitrosation. Nitrites 61-68 myoglobin Homo sapiens 120-129 32891753-5 2020 Herein, using purified myoglobin and isolated mitochondria, we characterize and directly compare the nitrite reductase activities of mitochondria and myoglobin and assess their contribution to mitochondrial S-nitrosation. Nitrites 101-108 myoglobin Homo sapiens 23-32 32891753-5 2020 Herein, using purified myoglobin and isolated mitochondria, we characterize and directly compare the nitrite reductase activities of mitochondria and myoglobin and assess their contribution to mitochondrial S-nitrosation. Nitrites 101-108 myoglobin Homo sapiens 150-159 32891753-7 2020 Further, deoxygenated myoglobin catalyzes the nitrite-dependent S-nitrosation of mitochondrial proteins. Nitrites 46-53 myoglobin Homo sapiens 22-31 32891753-9 2020 Using a Chinese Hamster Ovary cell model stably transfected with human myoglobin, we show that both myoglobin and mitochondrial complex I expression are required for nitrite-dependent attenuation of cell death after anoxia/reoxygenation. Nitrites 166-173 myoglobin Homo sapiens 71-80 32891753-9 2020 Using a Chinese Hamster Ovary cell model stably transfected with human myoglobin, we show that both myoglobin and mitochondrial complex I expression are required for nitrite-dependent attenuation of cell death after anoxia/reoxygenation. Nitrites 166-173 myoglobin Homo sapiens 100-109 32891753-10 2020 These data expand the understanding of myoglobin"s role both as a nitrite reductase to a mediator of S-nitrosation and as a regulator of mitochondrial function, and have implications for nitrite-mediated cardioprotection after I/R. Nitrites 66-73 myoglobin Homo sapiens 39-48 33024169-1 2020 Recently, it was suggested that the nitrite (NO2-) produced from NO3- by oral bacteria might contribute to oral and general health. Nitrites 36-43 NBL1, DAN family BMP antagonist Homo sapiens 65-68 32980539-9 2020 In aged flies, nitrite supplementation significantly downregulated dTOR and upregulated dSir2 gene expression. Nitrites 15-22 Target of rapamycin Drosophila melanogaster 67-71 32980539-9 2020 In aged flies, nitrite supplementation significantly downregulated dTOR and upregulated dSir2 gene expression. Nitrites 15-22 Sirtuin 1 Drosophila melanogaster 88-93 32866809-7 2020 (3) Intracellular NO and supernatant nitrite levels were increased by inhibiting SIRT1 in the PE group. Nitrites 37-44 sirtuin 1 Homo sapiens 81-86 32666456-7 2020 The results of metagenomics and metatranscriptomics revealed that the nitrite oxidation process was blocked by the transcriptional suppression of nitrite oxidoreductase and the entire nitrogen metabolism process was dominated by the partial nitritation and anammox process. Nitrites 70-77 thioredoxin reductase 1 Homo sapiens 154-168 32666456-7 2020 The results of metagenomics and metatranscriptomics revealed that the nitrite oxidation process was blocked by the transcriptional suppression of nitrite oxidoreductase and the entire nitrogen metabolism process was dominated by the partial nitritation and anammox process. Nitrites 146-153 thioredoxin reductase 1 Homo sapiens 154-168 32524996-9 2020 Altogether, boosting this nitrate-nitrite-NO signaling pathway resulted in the decreases of vascular NADPH oxidase-derived oxidative stress and endothelial dysfunction, and consequently protected ApoE-/- mice against atherosclerosis. Nitrites 34-41 apolipoprotein E Mus musculus 196-200 32377760-12 2020 Interestingly, PEDF levels were negatively correlated with plasma nitrite/nitrate levels and erectile function in DMED patients and STZ-induced diabetic rats. Nitrites 66-73 serpin family F member 1 Homo sapiens 15-19 32755471-12 2020 Nitrite may be a safe therapy to concominantly improve multiple features of the metabolic syndrome including hypertension, insulin resistance, and endothelial dysfunction. Nitrites 0-7 insulin Homo sapiens 123-130 32825477-2 2020 With an increase in the amount of nitrite-based accelerator, the hydration of C3A, C3S, and betaC2S in the cement is accelerated, thereby improving its early strength and effectively preventing the initial frost damage. Nitrites 34-41 complement C3 Homo sapiens 78-86 32899278-2 2020 As the calcium nitrite content increased, the generation rate and generated amount of nitrite-based hydration products also increased, owing to the rapid reaction between NO2- ions in calcium nitrite and C3A(Al2O3). Nitrites 15-22 complement C3 Homo sapiens 204-207 32806494-0 2020 Systemic Insulin Resistance and Metabolic Perturbations in Chow Fed Inducible Nitric Oxide Synthase Knockout Male Mice: Partial Reversal by Nitrite Supplementation. Nitrites 140-147 nitric oxide synthase 2, inducible Mus musculus 68-99 32806494-9 2020 Obesity, gluconeogenesis, and adipose tissue insulin signaling were only partially reversed in nitrite supplemented iNOS-/- mice. Nitrites 95-102 nitric oxide synthase 2, inducible Mus musculus 116-120 32806494-10 2020 Our results thus demonstrate that nitrite supplementation to iNOS-/- mice improves insulin sensitivity and metabolic homeostasis, thus further highlighting the metabolic role of iNOS. Nitrites 34-41 nitric oxide synthase 2, inducible Mus musculus 61-65 32806494-10 2020 Our results thus demonstrate that nitrite supplementation to iNOS-/- mice improves insulin sensitivity and metabolic homeostasis, thus further highlighting the metabolic role of iNOS. Nitrites 34-41 nitric oxide synthase 2, inducible Mus musculus 178-182 32070846-4 2020 A colorimetric method for nitrite detection has been developed with an outstanding correlation coefficient (R2 = 0.9944), a wide linear range (1-75 muM) and 0.73 muM limit of detection (at S/N = 3) for nitrite ions. Nitrites 26-33 latexin Homo sapiens 148-151 32759980-6 2020 Western blotting showed expression of sialin, a known nitrate transporter, in the lacrimal glands and other eye components, and also xanthine oxidoreductase, a nitrate and nitrite reductase, in cornea and sclera. Nitrites 172-179 xanthine dehydrogenase Homo sapiens 133-156 32012385-3 2020 N removal to low effluent and nitrate and nitrite (NO3 - + NO2 - ) concentrations occurs mainly via SND by operating the aerated zone at low DO, but still achieving near-complete ammonium (NH4 + ) removal. Nitrites 42-49 NBL1, DAN family BMP antagonist Homo sapiens 51-54 32849729-8 2020 During hypoxia and anoxia, NO3 in the cytosol is metabolised to produce nitrite (NO2), which is reduced to form NO via the reductive pathway in the mitochondria. Nitrites 72-79 NBL1, DAN family BMP antagonist Homo sapiens 27-30 32457044-9 2020 We also report that CblC exhibits nitrite reductase activity, converting cob(I)alamin and nitrite to NOCbl. Nitrites 34-41 Cbl proto-oncogene C Homo sapiens 20-24 32457044-11 2020 The newly described nitrite reductase and denitration activities of CblC extend its catalytic versatility, adding to its known decyanation and dealkylation activities. Nitrites 20-27 Cbl proto-oncogene C Homo sapiens 68-72 32765562-6 2020 NO3 - that is not assimilated and utilized in plant tissues is converted via enzyme-catalyzed reactions to nitrite (NO2 -), which is toxic to plants and harmful to human health. Nitrites 107-114 NBL1, DAN family BMP antagonist Homo sapiens 0-3 32224135-0 2020 Consistent gastric pH-dependent effects of suppressors of gastric acid secretion on the antihypertensive responses to oral nitrite. Nitrites 123-130 phenylalanine hydroxylase Homo sapiens 19-21 32224135-9 2020 Our results clearly indicate that SGAS impair nitrite-induced gastric formation of NO and vasoactive RXNO in a pH-dependent manner, thus resulting in impaired responses to oral nitrite. Nitrites 46-53 phenylalanine hydroxylase Homo sapiens 111-113 32070846-4 2020 A colorimetric method for nitrite detection has been developed with an outstanding correlation coefficient (R2 = 0.9944), a wide linear range (1-75 muM) and 0.73 muM limit of detection (at S/N = 3) for nitrite ions. Nitrites 26-33 latexin Homo sapiens 162-165 32203798-7 2020 More importantly, the sensor has a high recovery rate when it is used to detect nitrite in tap water, mineral water, and sausage, indicating the feasibility of using this sensor in practical applications. Nitrites 80-87 nuclear RNA export factor 1 Homo sapiens 91-94 32035920-0 2020 Hydrogen sulfide stimulates xanthine oxidoreductase conversion to nitrite reductase and formation of NO. Nitrites 66-73 xanthine dehydrogenase Mus musculus 28-51 32035920-3 2020 Recent reports have challenged this dogma by identifying a beneficial function for XOR, under similar hypoxic/acidic conditions, whereby XOR catalyzes the reduction of nitrite (NO2-) to nitric oxide (NO) through poorly defined mechanisms. Nitrites 168-175 xanthine dehydrogenase Mus musculus 83-86 32035920-3 2020 Recent reports have challenged this dogma by identifying a beneficial function for XOR, under similar hypoxic/acidic conditions, whereby XOR catalyzes the reduction of nitrite (NO2-) to nitric oxide (NO) through poorly defined mechanisms. Nitrites 168-175 xanthine dehydrogenase Mus musculus 137-140 31880165-9 2020 The oxygen-dependent regulation of NO degradation by Cygb is also reviewed along with how Cygb paradoxically generates NO from nitrite under anaerobic conditions. Nitrites 127-134 cytoglobin Mus musculus 90-94 32574223-1 2020 PURPOSE: Nitrate (NO3-), through its conversion to nitrite (NO2-) and nitric oxide, has been shown to increase exercise tolerance in healthy younger adults and older diseased patients. Nitrites 51-58 NBL1, DAN family BMP antagonist Homo sapiens 18-21 32366372-7 2020 Moreover, AOPPs triggered the production of reactive oxygen species and nitrite by ERK and P38 signal and this, in turn, led to an upregulation of proliferation and migration. Nitrites 72-79 Eph receptor B1 Rattus norvegicus 83-86 32366372-7 2020 Moreover, AOPPs triggered the production of reactive oxygen species and nitrite by ERK and P38 signal and this, in turn, led to an upregulation of proliferation and migration. Nitrites 72-79 mitogen activated protein kinase 14 Rattus norvegicus 91-94 32173492-8 2020 Overexpression of TUG1 enhanced cell viability, decreased LDH release, decreased nitrite and PGE2 production after TNF-alpha treatment in HT-29 cells. Nitrites 81-88 taurine up-regulated 1 Homo sapiens 18-22 32300065-6 2020 The lower arterial pressure and enhanced natriuresis during high salt loading in Pkd1 knockout mice were associated with lower urinary nitrite/nitrate excretion and markedly increased urinary PGE2 excretion, whereas GFR, plasma renin concentration, and urinary endothelin-1 excretion were similar between knockout and control mice. Nitrites 135-142 polycystin 1, transient receptor potential channel interacting Mus musculus 81-85 32551436-5 2020 Based on theoretical calculations as well as a practical approach, we determined that the critical nitrite concentrations for nitrite oxidizing bacteria lie between 12 and 30 mgN/L at pH 6 to 6.8. Nitrites 99-106 helt bHLH transcription factor Homo sapiens 175-178 32551436-5 2020 Based on theoretical calculations as well as a practical approach, we determined that the critical nitrite concentrations for nitrite oxidizing bacteria lie between 12 and 30 mgN/L at pH 6 to 6.8. Nitrites 126-133 helt bHLH transcription factor Homo sapiens 175-178 32551436-6 2020 Consequently, we decided that the sensor should be able to reliably measure concentrations up to 50 mgN/L, which is about double the value of the critical nitrite concentration. Nitrites 155-162 helt bHLH transcription factor Homo sapiens 100-103 32551436-9 2020 Nevertheless, the sensor delivered reliable measurements for nitrite concentrations of 5-50 mgN/L or higher. Nitrites 61-68 helt bHLH transcription factor Homo sapiens 92-95 32106030-6 2020 On the contrary, only 4 mM catechin hydrate could enhance the rate of methemoglobin formation even in absence of nitrite and the rate of the reaction was (6.088 +- 0.31) x 10-5 min-1 which is comparable with that of 400 muM nitrite. Nitrites 224-231 hemoglobin subunit gamma 2 Homo sapiens 70-83 32365846-7 2020 Lower levels of IFN-gamma, TNF, fractalkine, IL-2, and nitrite were present in the co-cultures with clpB/ wbtC splenocytes than in those with splenocytes from LVS-immunized rats. Nitrites 55-62 caseinolytic mitochondrial matrix peptidase chaperone subunit B Rattus norvegicus 101-105 32087553-7 2020 Whole blood nitrite levels correlated inversely with plasma NO2-CLA (p = 0.039) but not with cGMP. Nitrites 12-19 selectin P ligand Homo sapiens 64-67 31793100-4 2020 Under limited N supply, compared with that of wild-type (WT) seedlings, the zmnlp5 mutant seedlings accumulated less nitrate and nitrite in the root tissues and ammonium in the shoot tissues. Nitrites 129-136 Protein RKD4 Zea mays 76-82 32036525-11 2020 The expression of caspase 3 and Bax level showed enhanced induction of immunoexpression, especially in the high doses of nitrites. Nitrites 121-129 caspase 3 Rattus norvegicus 18-27 32036525-11 2020 The expression of caspase 3 and Bax level showed enhanced induction of immunoexpression, especially in the high doses of nitrites. Nitrites 121-129 BCL2 associated X, apoptosis regulator Rattus norvegicus 32-35 32036525-12 2020 On the other hand, the maximal immunoexpression level of anti-apoptotic marker Bcl2 was found in lower doses of nitrites, whereas marked decrease of Bcl2 levels was observed in the higher doses. Nitrites 112-120 BCL2, apoptosis regulator Rattus norvegicus 79-83 31883231-10 2020 Plasma nitrite levels reduced after the first session of PR (0.074 [0.079] muM vs. 0.061 [0.04] muM; p = .027). Nitrites 7-14 latexin Homo sapiens 75-78 31883231-10 2020 Plasma nitrite levels reduced after the first session of PR (0.074 [0.079] muM vs. 0.061 [0.04] muM; p = .027). Nitrites 7-14 latexin Homo sapiens 96-99 31793100-8 2020 We further show that ZmNLP5 directly regulates the expression of nitrite reductase 1.1 (ZmNIR1.1) by binding to the nitrate-responsive cis-element (NRE) at the 5" UTR of the gene. Nitrites 65-72 Protein RKD4 Zea mays 21-27 31739104-9 2020 Administration of CCl4 to rat severely depleted the activity level of catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD), and reduced glutathione (GSH) concentration while appreciably increased the concentration of thiobarbituric acid reactive substances (TBARS), H2O2, nitrite, TNF-alpha, IL-1beta and IL-2 in lung and kidney tissues of rat. Nitrites 283-290 C-C motif chemokine ligand 4 Rattus norvegicus 18-22 32228174-8 2021 Interestingly, we found that the changes mentioned were linked with reduced levels of nitrites both at 24 h (< 171 pmol/mug protein; P < 0.001), and 48 h (< 250 pmol/mug protein; P < 0.05), which was associated with a reduced expression of mRNA of eNOS in endothelial cells incubated with TPP and high glucose. Nitrites 86-94 nitric oxide synthase 3 Homo sapiens 248-252 31927728-2 2020 Anolytic nitrite enhanced the electricity generation capability of the MFCs at relatively low concentrations (< 60 mg L-1) but inhibited the activity of anodic electrogenic bacteria at high concentrations. Nitrites 9-16 immunoglobulin kappa variable 1-16 Homo sapiens 118-121 31927728-5 2020 At an influent nitrite concentration of 60 mg L-1, the coulombic efficiency of the MFC was minimized at approximately 5.4%, and the charge transfer resistance was also lowest, while the concentrations of extracellular polymeric substances (EPS) and cytochrome c were both maximized. Nitrites 15-22 immunoglobulin kappa variable 1-16 Homo sapiens 46-49 31927728-6 2020 Higher anolytic nitrite concentrations (> 60 mg L-1) inhibited the production of cytochrome c and EPS and increased the charge transfer resistance, thereby reducing the efficiency of electron transfer in the anodic biofilm. Nitrites 16-23 immunoglobulin kappa variable 1-16 Homo sapiens 48-51 31927728-6 2020 Higher anolytic nitrite concentrations (> 60 mg L-1) inhibited the production of cytochrome c and EPS and increased the charge transfer resistance, thereby reducing the efficiency of electron transfer in the anodic biofilm. Nitrites 16-23 cytochrome c, somatic Homo sapiens 81-93 31658361-1 2020 BACKGROUND AND PURPOSE: Although it has been reported that bovine CAII is capable of generating NO from nitrite, the function and mechanism of CAII in nitrite-dependent NO formation and vascular responses remain controversial. Nitrites 104-111 carbonic anhydrase 2 Bos taurus 66-70 31967806-0 2020 Investigation into the Concentrations and Sources of Nitrates and Nitrites in Milk and Plant-based Powders. Nitrites 66-74 Weaning weight-maternal milk Bos taurus 78-82 31967806-1 2020 Milk powders in the United States (US) may contain nitrates and nitrites from several potential sources. Nitrites 64-72 Weaning weight-maternal milk Bos taurus 0-4 31967806-3 2020 Recently, milk powders manufactured in the US have been rejected during import to other countries due to having nitrite concentrations greater than 2 mg/kg (ppm). Nitrites 112-119 Weaning weight-maternal milk Bos taurus 10-14 31967806-4 2020 To date, the concentrations of nitrates and nitrites in milk and plant-based powders in the US is unknown. Nitrites 44-52 Weaning weight-maternal milk Bos taurus 56-60 31967806-11 2020 Nitrite was detected at concentrations greater than 2 mg/kg in 5 out of 39 different brands of retail milk and plant-based powders. Nitrites 0-7 Weaning weight-maternal milk Bos taurus 102-106 31940195-5 2020 ClNO2 and chloramine (NH2Cl, NHCl2, NCl3) production occurred in the applied bleach via aqueous reactions involving nitrite (NO2-) and ammonia (NH3), respectively. Nitrites 116-123 calpain 5 Homo sapiens 36-40 31658361-1 2020 BACKGROUND AND PURPOSE: Although it has been reported that bovine CAII is capable of generating NO from nitrite, the function and mechanism of CAII in nitrite-dependent NO formation and vascular responses remain controversial. Nitrites 151-158 carbonic anhydrase 2 Bos taurus 143-147 31658361-2 2020 We tested the hypothesis that CAII catalyzes NO formation from nitrite and contributes to nitrite dependent inhibition of platelet activation and vasodilation. Nitrites 63-70 carbonic anhydrase 2 Mus musculus 30-34 31658361-2 2020 We tested the hypothesis that CAII catalyzes NO formation from nitrite and contributes to nitrite dependent inhibition of platelet activation and vasodilation. Nitrites 90-97 carbonic anhydrase 2 Mus musculus 30-34 31658361-3 2020 EXPERIMENTAL APPROACH: The role of CAII in enzymatic NO generation was investigated by measuring NO formation from the reaction of isolated human and bovine CAII with nitrite using NO photolysis-chemiluminescence. Nitrites 167-174 carbonic anhydrase 2 Homo sapiens 35-39 31658361-3 2020 EXPERIMENTAL APPROACH: The role of CAII in enzymatic NO generation was investigated by measuring NO formation from the reaction of isolated human and bovine CAII with nitrite using NO photolysis-chemiluminescence. Nitrites 167-174 carbonic anhydrase 2 Bos taurus 157-161 31658361-4 2020 A CAII-deficient mouse model was used to determine the role of CAII in red blood cell mediated nitrite reduction and vasodilation. Nitrites 95-102 carbonic anhydrase 2 Mus musculus 63-67 31658361-5 2020 KEY RESULTS: We found that the commercially available purified bovine CAII exhibited limited and non-enzymatic NO-generating reactivity in the presence of nitrite with or without addition of the CA inhibitor dorzolamide; the NO formation was eliminated with purification of the enzyme. Nitrites 155-162 carbonic anhydrase 2 Bos taurus 70-74 31704330-5 2020 In addition, we found that nitrite exposure could alter the expression patterns of some key apoptosis-related genes (Caspase-3, Caspase-8, Caspase-9, p53, Bax, and Bcl-2). Nitrites 27-34 caspase-8 Takifugu rubripes 128-137 31704330-5 2020 In addition, we found that nitrite exposure could alter the expression patterns of some key apoptosis-related genes (Caspase-3, Caspase-8, Caspase-9, p53, Bax, and Bcl-2). Nitrites 27-34 caspase-9 Takifugu rubripes 139-148 31704330-5 2020 In addition, we found that nitrite exposure could alter the expression patterns of some key apoptosis-related genes (Caspase-3, Caspase-8, Caspase-9, p53, Bax, and Bcl-2). Nitrites 27-34 apoptosis regulator BAX Takifugu rubripes 155-158 31704330-5 2020 In addition, we found that nitrite exposure could alter the expression patterns of some key apoptosis-related genes (Caspase-3, Caspase-8, Caspase-9, p53, Bax, and Bcl-2). Nitrites 27-34 apoptosis regulator Bcl-2 Takifugu rubripes 164-169 31704330-6 2020 This indicated that the caspase-dependent apoptotic pathway and p53-Bax-Bcl-2 pathway might be involved in apoptosis induced by nitrite exposure. Nitrites 128-135 apoptosis regulator BAX Takifugu rubripes 68-71 31704330-6 2020 This indicated that the caspase-dependent apoptotic pathway and p53-Bax-Bcl-2 pathway might be involved in apoptosis induced by nitrite exposure. Nitrites 128-135 apoptosis regulator Bcl-2 Takifugu rubripes 72-77 31783303-6 2020 Nitrite significantly upregulated hsp70, hsp90, tnf-alpha, il-6, il-12, and baff mRNA levels after 96 h of exposure. Nitrites 0-7 tumor necrosis factor b (TNF superfamily, member 2) Takifugu rubripes 48-57 32047580-8 2020 Cynaroside inhibited IL-1beta-induced expression of catabolic factors (nitrite, iNOS, ROS, PGE2, Cox-2, MMP-1, MMP-3, MMP-13, and ADAMTS-4) and degradation of anabolic factors (collagen type II and aggrecan). Nitrites 71-78 interleukin 1 alpha Rattus norvegicus 21-29 31854935-3 2020 The results showed that after the operation of intermittent starvation, the NO3--N concentration at the end of the aerobic phase decreased to 8.72 mg L-1 and the NO2- accumulation percentage reached 83.18%, which indicated that the nitrite oxidizing bacteria (NOB) activity was effectively inhibited and that the nitritation performance improved. Nitrites 232-239 NBL1, DAN family BMP antagonist Homo sapiens 76-79 31854935-3 2020 The results showed that after the operation of intermittent starvation, the NO3--N concentration at the end of the aerobic phase decreased to 8.72 mg L-1 and the NO2- accumulation percentage reached 83.18%, which indicated that the nitrite oxidizing bacteria (NOB) activity was effectively inhibited and that the nitritation performance improved. Nitrites 232-239 L1 cell adhesion molecule Homo sapiens 150-153 31979350-9 2020 Interestingly, LPS-induced TNFalpha and nitrite levels were far lower in CB2 knockout cultures compared to wildtypes, while IL-6 levels did not differ. Nitrites 40-47 cannabinoid receptor 2 (macrophage) Mus musculus 73-76 31783303-6 2020 Nitrite significantly upregulated hsp70, hsp90, tnf-alpha, il-6, il-12, and baff mRNA levels after 96 h of exposure. Nitrites 0-7 interleukin-6 Takifugu rubripes 59-63 31610241-7 2020 Western immunoblotting analysis revealed that nitrite prevented the increase in Nox1 expression in the CC from 2K1C rats. Nitrites 46-53 NADPH oxidase 1 Rattus norvegicus 80-84 31689491-9 2020 In vivo, inhibition of NO synthases and xanthine oxidoreductase decreased nitrite levels in homozygotes but not in control mice. Nitrites 74-81 xanthine dehydrogenase Mus musculus 40-63 31449936-12 2020 We found a direct correlation between HIF-1alpha and 8-isoprostane and nitrite plasma levels. Nitrites 71-78 hypoxia inducible factor 1 subunit alpha Homo sapiens 38-48 31449936-13 2020 CONCLUSIONS: We concluded that LIC induces an early oxidative/nitrosative stress in the arm followed by an increase of HIF-1alpha plasma levels correlated with 8-isoprostane and nitrite levels, possibly as a local response. Nitrites 178-185 hypoxia inducible factor 1 subunit alpha Homo sapiens 119-129 32496983-8 2020 Protein nitration also occurs by activation of myeloperoxidase and H2O2, promoting oxidation of nitrite (NO2 - ). Nitrites 96-103 myeloperoxidase Homo sapiens 47-62 31595466-6 2020 In cytosol the NO3 - is reduced to NO2 - by cytosolic nitrate reductase (NR) and the produced NO2 - is further reduced to NH4 + by nitrite reductase (NiR) in plastids. Nitrites 131-138 NBL1, DAN family BMP antagonist Homo sapiens 15-18 31595467-4 2020 If NO3 - is a primary source, it is transported from roots and then it is rapidly converted to nitrite (NO2 -) by nitrate reductase (NR) (EC 1.6.6.1) which is a critical and very important enzyme for this conversion. Nitrites 95-102 nitrate reductase [NADH] Solanum lycopersicum 114-131 31595467-4 2020 If NO3 - is a primary source, it is transported from roots and then it is rapidly converted to nitrite (NO2 -) by nitrate reductase (NR) (EC 1.6.6.1) which is a critical and very important enzyme for this conversion. Nitrites 95-102 nitrate reductase [NADH] Solanum lycopersicum 133-135 31765889-5 2020 Mechanistically, subcutaneous primary mouse adipocytes exposed to palmitate (PA) and treated with nitrite exhibited higher mitochondrial respiration, increased protein expression of total mitochondrial complexes and elevated gene expression of the thermogenesis gene UCP-1, as well as of the creatine transporter SLC6A8. Nitrites 98-105 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 267-272 32351209-6 2020 Results showed that the treatment using miltefosine, ICHQ or ICHQ/Mic induced significantly higher anti-parasite IFN-gamma, IL-12, GM-CSF, nitrite and IgG2a isotype antibody levels, which were associated with low IL-4 and IL-10 production. Nitrites 139-146 cystatin E/M Mus musculus 61-65 32351209-6 2020 Results showed that the treatment using miltefosine, ICHQ or ICHQ/Mic induced significantly higher anti-parasite IFN-gamma, IL-12, GM-CSF, nitrite and IgG2a isotype antibody levels, which were associated with low IL-4 and IL-10 production. Nitrites 139-146 microphthalmia Japan Mus musculus 66-69 32351209-6 2020 Results showed that the treatment using miltefosine, ICHQ or ICHQ/Mic induced significantly higher anti-parasite IFN-gamma, IL-12, GM-CSF, nitrite and IgG2a isotype antibody levels, which were associated with low IL-4 and IL-10 production. Nitrites 139-146 cystatin E/M Mus musculus 53-57 32982068-0 2020 Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia. Nitrites 60-67 selectin P Homo sapiens 15-25 31765889-5 2020 Mechanistically, subcutaneous primary mouse adipocytes exposed to palmitate (PA) and treated with nitrite exhibited higher mitochondrial respiration, increased protein expression of total mitochondrial complexes and elevated gene expression of the thermogenesis gene UCP-1, as well as of the creatine transporter SLC6A8. Nitrites 98-105 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 Mus musculus 313-319 31350908-7 2019 This muscle nitrate reservoir has been found to be an important source of nitrite and nitric oxide (NO) via its reduction by tissue xanthine oxidoreductase. Nitrites 74-81 xanthine dehydrogenase Homo sapiens 132-155 31763675-9 2019 In the in vitro study, overexpression of DDAH-2 increased the levels of nitrite and intracellular cGMP, while the DDAH-2 knockdown induced the opposite effect. Nitrites 72-79 dimethylarginine dimethylaminohydrolase 2 Mus musculus 41-47 31600544-2 2019 Research has revealed an alternative NO-generating pathway, independent of NO synthase (NOS), in which the inorganic anions nitrate (NO3-) and nitrite (NO2-) are serially reduced to form NO. Nitrites 143-150 nitric oxide synthase 1, neuronal Mus musculus 75-86 31590920-4 2019 Co-treatment of cells with a cocktail of pro-inflammatory cytokines (IL-1beta, IFNgamma and TNFalpha) caused a marked increase in caspase activation and a reduction in cell viability, effects attenuated by inclusion of each EET; this was also associated with a reduction in cytokine-induced NFkappaB activation and nitrite accumulation. Nitrites 315-322 interleukin 1 beta Rattus norvegicus 69-77 31590920-4 2019 Co-treatment of cells with a cocktail of pro-inflammatory cytokines (IL-1beta, IFNgamma and TNFalpha) caused a marked increase in caspase activation and a reduction in cell viability, effects attenuated by inclusion of each EET; this was also associated with a reduction in cytokine-induced NFkappaB activation and nitrite accumulation. Nitrites 315-322 interleukin 18 Rattus norvegicus 79-87 31590920-4 2019 Co-treatment of cells with a cocktail of pro-inflammatory cytokines (IL-1beta, IFNgamma and TNFalpha) caused a marked increase in caspase activation and a reduction in cell viability, effects attenuated by inclusion of each EET; this was also associated with a reduction in cytokine-induced NFkappaB activation and nitrite accumulation. Nitrites 315-322 tumor necrosis factor Rattus norvegicus 92-100 31766976-1 2019 Background The enterosalivary nitrate-nitrite-nitric oxide pathway is an alternative pathway of nitric oxide generation, potentially linking the oral microbiome to insulin resistance and blood pressure (BP). Nitrites 30-58 insulin Homo sapiens 164-171 31768780-4 2019 A positive correlation was found between the plasma content of nitrites and nitrates and the level of transcripts of VCAM1, ICAM1 genes in peripheral blood leukocytes. Nitrites 63-71 vascular cell adhesion molecule 1 Homo sapiens 117-122 31513867-9 2019 Following nitrite inhalation, eRVSP remained unchanged but platelet activation was suppressed as evidenced by inhibition of adenosine diphosphate (ADP)-induced P-selectin expression and increase in phosphorylated vasodilator-stimulated phosphoprotein (P-VASPSer239) in platelets. Nitrites 10-17 vasodilator stimulated phosphoprotein Homo sapiens 213-250 31754421-5 2019 Acquired form is caused by exogenous oxidizing agents, such as nitrites or certain medications, while hereditary types of disease are the result of genetic deficiency in cytochrome B5 reductase, an enzyme responsible for MetHb reduction to hemoglobin. Nitrites 63-71 hemoglobin subunit gamma 2 Homo sapiens 221-226 29609494-7 2019 Diminution of SOD, GPx, GR and CA activity was congruent with elevated nitrite levels and upregulation of iNOS and UCP-2 expression, without any DNA damage. Nitrites 71-78 catalase Rattus norvegicus 31-33 31768780-4 2019 A positive correlation was found between the plasma content of nitrites and nitrates and the level of transcripts of VCAM1, ICAM1 genes in peripheral blood leukocytes. Nitrites 63-71 intercellular adhesion molecule 1 Homo sapiens 124-129 31479766-13 2019 However, co-administration of NaSH and nitrite resulted in further improvement in serum insulin level, GTT, PTT, liver function, oxidative stress, protein level and mRNA expression of GLUT4, as well as mRNA expression of H2S-producing enzymes in diabetic rats. Nitrites 39-46 solute carrier family 2 member 4 Rattus norvegicus 184-189 31394201-11 2019 Genotypes and haplotypes of DDAH1 were associated with ADMA levels in ED (P < 0.05), while haplotypes of DDAH2 were associated with levels of nitrite in ED (P < 0.05). Nitrites 145-152 dimethylarginine dimethylaminohydrolase 2 Homo sapiens 108-113 31394201-12 2019 Erectile dysfunction patients show an association between DDAH1 and DDAH2 polymorphisms with ADMA levels, which in turn are negatively correlated with nitrite levels. Nitrites 151-158 dimethylarginine dimethylaminohydrolase 1 Homo sapiens 58-63 31394201-12 2019 Erectile dysfunction patients show an association between DDAH1 and DDAH2 polymorphisms with ADMA levels, which in turn are negatively correlated with nitrite levels. Nitrites 151-158 dimethylarginine dimethylaminohydrolase 2 Homo sapiens 68-73 31541562-6 2019 ABSTRACT: Dietary nitrate (NO3 - ) supplementation, which increases plasma nitrite (NO2 - ) concentration, has been reported to attenuate skeletal muscle fatigue development. Nitrites 75-82 NBL1, DAN family BMP antagonist Mus musculus 27-30 31696161-7 2019 Docking observation suggested an inhibitory role of cyclooxygenase-1 or -2 for compounds A3, A4 and A5 in addition to their capacity to inhibit nitrite, interleukin-6, and nitric oxide synthase-II and cyclooxygenase-2 expression. Nitrites 144-151 prostaglandin-endoperoxide synthase 1 Mus musculus 52-74 31496247-4 2019 NAC-SNO was found to prevent, much better than nitrite, accumulation of reactive aldehydes and hydroxynonenal protein modification. Nitrites 47-54 synuclein alpha Homo sapiens 0-3 31203953-5 2019 This fully automated analyzer had a limit of detection of 0.02 mumol L-1 for nitrite and 0.14 mumol L-1 for nitrate. Nitrites 77-84 L1 cell adhesion molecule Homo sapiens 69-72 31496247-5 2019 In condition like those used by the industry for meat products processing, NAC-SNO acts better than nitrite to provide antioxidant protection without the side effect of N-nitrosation, oxidation, and the loss of nutrient generated by nitrite. Nitrites 233-240 synuclein alpha Homo sapiens 75-78 31610400-3 2019 NAMPT was positively correlated to nitrite (r = 0.217; P = 0.034) and inversely related to sFLT-1 (r = -0.340; P = 0.029) in healthy pregnant women, but inversely related to nitrite (r = -0.259; P = 0.035) and positively correlated to sFLT-1 (r = 0.326; P = 0.007) in preeclamptic patients, suggesting that NAMPT inhibits NO formation and interacts with the antiangiogenic factor sFLT-1 in preeclampsia. Nitrites 35-42 nicotinamide phosphoribosyltransferase Homo sapiens 0-5 30632647-4 2019 In our study, we demonstrated that GEN-27 administration (1, 5, or 10 muM) dose-dependently inhibited nitrite and nitric oxide (NO) levels in LPS-stimulated RAW264.7 cells. Nitrites 102-109 toll-like receptor 4 Mus musculus 142-145 31300167-7 2019 Such enrichment method resulted in a hard and thick anammox biofilm with a special granular morphology, and the nitrite tolerance concentration could reach 500 mg-N L-1. Nitrites 112-119 immunoglobulin kappa variable 1-16 Homo sapiens 165-168 31610400-3 2019 NAMPT was positively correlated to nitrite (r = 0.217; P = 0.034) and inversely related to sFLT-1 (r = -0.340; P = 0.029) in healthy pregnant women, but inversely related to nitrite (r = -0.259; P = 0.035) and positively correlated to sFLT-1 (r = 0.326; P = 0.007) in preeclamptic patients, suggesting that NAMPT inhibits NO formation and interacts with the antiangiogenic factor sFLT-1 in preeclampsia. Nitrites 174-181 nicotinamide phosphoribosyltransferase Homo sapiens 0-5 31351400-3 2019 At 48 h, nitrite exposure decreased the mRNA levels of mitochondrial MnSOD (mMn-SOD), CAT, and GPx. Nitrites 9-16 superoxide dismutase 2, mitochondrial Mus musculus 76-83 31348674-2 2019 Dietary NO3-, commonly found in leafy green and root vegetables, undergoes sequential reduction to nitrite and nitric oxide (NO) via the enterosalivary circulation. Nitrites 99-106 NBL1, DAN family BMP antagonist Homo sapiens 8-11 31423762-3 2019 By utilizing the porphyrinic linkers as catalytically active units, the GQD-MOF material exhibits a better electrochemical sensing activity toward nitrite in aqueous solutions compared to both the pristine MOF and GQD. Nitrites 147-154 lysine acetyltransferase 8 Homo sapiens 76-79 31251976-7 2019 While 2K1C hypertension decreased nuclear Nrf2 accumulation, both doses of nitrite increased nuclear Nrf2 accumulation and mRNA expression of Nrf2-regulated genes including superoxide dismutase-1 (SOD1), catalase (CAT), glutathione peroxidase (GPX), thioredoxin-1(TRDX-1) and -2 (TRDX-2). Nitrites 75-82 NFE2 like bZIP transcription factor 2 Rattus norvegicus 42-46 31251976-7 2019 While 2K1C hypertension decreased nuclear Nrf2 accumulation, both doses of nitrite increased nuclear Nrf2 accumulation and mRNA expression of Nrf2-regulated genes including superoxide dismutase-1 (SOD1), catalase (CAT), glutathione peroxidase (GPX), thioredoxin-1(TRDX-1) and -2 (TRDX-2). Nitrites 75-82 NFE2 like bZIP transcription factor 2 Rattus norvegicus 101-105 31251976-0 2019 Antioxidant and antihypertensive responses to oral nitrite involves activation of the Nrf2 pathway. Nitrites 51-58 NFE2 like bZIP transcription factor 2 Rattus norvegicus 86-90 31251976-7 2019 While 2K1C hypertension decreased nuclear Nrf2 accumulation, both doses of nitrite increased nuclear Nrf2 accumulation and mRNA expression of Nrf2-regulated genes including superoxide dismutase-1 (SOD1), catalase (CAT), glutathione peroxidase (GPX), thioredoxin-1(TRDX-1) and -2 (TRDX-2). Nitrites 75-82 NFE2 like bZIP transcription factor 2 Rattus norvegicus 101-105 31251976-3 2019 We hypothesized that nitrite treatment of two-kidney, one-clip (2K1C) hypertensive rats activates the Nrf2 pathway, promotes the transcription of antioxidant genes, and improves the vascular redox imbalance and dysfunction in this model. Nitrites 21-28 NFE2 like bZIP transcription factor 2 Rattus norvegicus 102-106 31251976-7 2019 While 2K1C hypertension decreased nuclear Nrf2 accumulation, both doses of nitrite increased nuclear Nrf2 accumulation and mRNA expression of Nrf2-regulated genes including superoxide dismutase-1 (SOD1), catalase (CAT), glutathione peroxidase (GPX), thioredoxin-1(TRDX-1) and -2 (TRDX-2). Nitrites 75-82 superoxide dismutase 1 Rattus norvegicus 173-195 31251976-7 2019 While 2K1C hypertension decreased nuclear Nrf2 accumulation, both doses of nitrite increased nuclear Nrf2 accumulation and mRNA expression of Nrf2-regulated genes including superoxide dismutase-1 (SOD1), catalase (CAT), glutathione peroxidase (GPX), thioredoxin-1(TRDX-1) and -2 (TRDX-2). Nitrites 75-82 superoxide dismutase 1 Rattus norvegicus 197-201 31251976-7 2019 While 2K1C hypertension decreased nuclear Nrf2 accumulation, both doses of nitrite increased nuclear Nrf2 accumulation and mRNA expression of Nrf2-regulated genes including superoxide dismutase-1 (SOD1), catalase (CAT), glutathione peroxidase (GPX), thioredoxin-1(TRDX-1) and -2 (TRDX-2). Nitrites 75-82 catalase Rattus norvegicus 204-212 31251976-7 2019 While 2K1C hypertension decreased nuclear Nrf2 accumulation, both doses of nitrite increased nuclear Nrf2 accumulation and mRNA expression of Nrf2-regulated genes including superoxide dismutase-1 (SOD1), catalase (CAT), glutathione peroxidase (GPX), thioredoxin-1(TRDX-1) and -2 (TRDX-2). Nitrites 75-82 catalase Rattus norvegicus 214-217 31251976-9 2019 These results suggest that activation of the Nrf2 pathway promotes antioxidant effects of nitrite, which may improve the vascular dysfunction in hypertension, even when nitrite is given at a sub-antihypertensive dose. Nitrites 90-97 NFE2 like bZIP transcription factor 2 Rattus norvegicus 45-49 31251976-9 2019 These results suggest that activation of the Nrf2 pathway promotes antioxidant effects of nitrite, which may improve the vascular dysfunction in hypertension, even when nitrite is given at a sub-antihypertensive dose. Nitrites 169-176 NFE2 like bZIP transcription factor 2 Rattus norvegicus 45-49 29858778-5 2019 After exposure to nitrite stress for 24 and 48 h, the intestine antioxidant enzyme (SOD, CAT, and GPx) activity and gene (hsp70 and ferritin) expression levels in the three C. butyricum groups were higher than those of the control. Nitrites 18-25 ATN24_RS18010 Clostridium butyricum 98-101 31552707-6 2019 Untreated Ins2Akita mice showed significant increases in urinary albumin excretion, histological changes, glomerular macrophage recruitment, the inflammatory cytokine KC-GRO/CXCL1, and urinary thiobarbituric acid reactive substances (TBARS) excretion as an indicator of oxidative stress, along with a significant reduction in kidney nitrate + nitrite levels compared to control mice at 18 weeks of age. Nitrites 343-350 insulin II Mus musculus 10-14 31173908-5 2019 In contrast, a NOS inhibitor, L-NAME or a low nitrite/nitrate diet treatment led to more pronounced decreases of nitrate levels in the skeletal muscle of both control and myoglobin deficient mice. Nitrites 46-53 myoglobin Mus musculus 171-180 31410575-5 2019 Under the optimal conditions, fluorescence linearly dropos in the 10 nM to 0.8 muM nitrite concentration range. Nitrites 83-90 latexin Homo sapiens 79-82 30968134-6 2019 The induction of AOX under aerobic conditions in response to various stresses can reduce electron transfer through complexes III and IV and thus prevents the leakage of electrons to nitrite and the subsequent accumulation of NO. Nitrites 182-189 acyl-CoA oxidase 1 Homo sapiens 17-20 30968134-7 2019 Excess NO under various stresses can inhibit complex IV; thus, the AOX pathway minimizes nitrite-dependent NO synthesis that would arise from enhanced electron leakage in the cytochrome pathway. Nitrites 89-96 acyl-CoA oxidase 1 Homo sapiens 67-70 30968134-9 2019 In contrast to its function under normoxia, AOX has a specific role under hypoxia, where AOX can facilitate nitrite-dependent NO production. Nitrites 108-115 acyl-CoA oxidase 1 Homo sapiens 44-47 30968134-9 2019 In contrast to its function under normoxia, AOX has a specific role under hypoxia, where AOX can facilitate nitrite-dependent NO production. Nitrites 108-115 acyl-CoA oxidase 1 Homo sapiens 89-92 31375925-1 2019 A cyclic voltammetric method is described for the determination of nitrite by using a multiwalled carbon nanotube paste electrode (MWCNT) that was modified with chitosan-functionalized silver nanoparticles (Chit-AgNPs). Nitrites 67-74 chitinase 1 Homo sapiens 207-211 31375925-4 2019 By combining the advantages of chitosan, AgNPs (in the form of Chit-AgNPs) and MWCNT, the assay exhibits a remarkable improvement in the cyclic voltammetric response towards the oxidation of nitrite at a typical peak potential of 0.81 V (vs. SCE) in buffer of pH 4.0. Nitrites 191-198 chitinase 1 Homo sapiens 63-67 31093850-11 2019 The nitrate/nitrite ratio was reduced in serum and in aortas of 6-month-old CD73-/- mice as compared to WT. Nitrites 12-19 5' nucleotidase, ecto Mus musculus 76-80 31002874-0 2019 Reciprocal regulation of sulfite oxidation and nitrite reduction by mitochondrial sulfite oxidase. Nitrites 47-54 sulfite oxidase Homo sapiens 82-97 31227868-4 2019 Nitrite and ammonium removal rates of up to 455 mg N-NO2- L-1 day-1 and 228 mg N-NH4+ L-1 were reached. Nitrites 0-7 L1 cell adhesion molecule Homo sapiens 58-61 31227868-4 2019 Nitrite and ammonium removal rates of up to 455 mg N-NO2- L-1 day-1 and 228 mg N-NH4+ L-1 were reached. Nitrites 0-7 L1 cell adhesion molecule Homo sapiens 86-89 31051259-1 2019 Nitrate (NO3-) contained in food and beverages can transiently increase nitric oxide (NO) availability following a stepwise reduction to nitrite (NO2-) by commensal bacteria in the oral cavity. Nitrites 137-144 NBL1, DAN family BMP antagonist Homo sapiens 9-12 31063820-6 2019 Mechanistically, protective effects of nitrite were abolished by NO scavenger and xanthine oxidase inhibitor, and inhibition of NADPH oxidase with apocynin attenuated LPS-induced oxidative stress similar to that of nitrite. Nitrites 39-46 xanthine dehydrogenase Mus musculus 82-98 31063820-8 2019 In LPS-activated macrophage cells, nitrite reduced NADPH oxidase activity and oxidative stress and these effects of nitrite were also abolished by NO scavenger and xanthine oxidase inhibitor, where xanthine oxidase-mediated reduction of nitrite attenuated NADPH oxidase activity in activated macrophages via a NO-dependent mechanism. Nitrites 35-42 xanthine dehydrogenase Mus musculus 164-180 31063820-8 2019 In LPS-activated macrophage cells, nitrite reduced NADPH oxidase activity and oxidative stress and these effects of nitrite were also abolished by NO scavenger and xanthine oxidase inhibitor, where xanthine oxidase-mediated reduction of nitrite attenuated NADPH oxidase activity in activated macrophages via a NO-dependent mechanism. Nitrites 35-42 xanthine dehydrogenase Mus musculus 198-214 31063820-8 2019 In LPS-activated macrophage cells, nitrite reduced NADPH oxidase activity and oxidative stress and these effects of nitrite were also abolished by NO scavenger and xanthine oxidase inhibitor, where xanthine oxidase-mediated reduction of nitrite attenuated NADPH oxidase activity in activated macrophages via a NO-dependent mechanism. Nitrites 116-123 xanthine dehydrogenase Mus musculus 164-180 31063820-8 2019 In LPS-activated macrophage cells, nitrite reduced NADPH oxidase activity and oxidative stress and these effects of nitrite were also abolished by NO scavenger and xanthine oxidase inhibitor, where xanthine oxidase-mediated reduction of nitrite attenuated NADPH oxidase activity in activated macrophages via a NO-dependent mechanism. Nitrites 116-123 xanthine dehydrogenase Mus musculus 198-214 31167903-0 2019 Mechanism of nitrite-dependent NO synthesis by human sulfite oxidase. Nitrites 13-20 sulfite oxidase Homo sapiens 53-68 31251052-2 2019 In the presence of a nitrite substrate, the Co(III) precatalyst, [Co(DIM)(NO2)2]+ (DIM = 2,3-dimethyl-1,4,8,11-tetraazacyclotetradeca-1,3-diene), is formed in situ. Nitrites 21-28 mitochondrially encoded cytochrome c oxidase III Homo sapiens 44-51 30941478-7 2019 Under the optimized conditions, the limits of detection achieved for glucose and nitrite were 27 mumol L-1 and 7 mumol L-1, respectively. Nitrites 81-88 immunoglobulin kappa variable 1-16 Homo sapiens 103-122 31113864-5 2019 Using bone marrow-derived macrophages from WT and RIP2-KO mice, we show that loss of RIP2 leads to deficient FcgammaR signaling and reactive oxygen species (ROS) production upon FcgammaR cross-linking without affecting cytokine secretion, phagocytosis, or nitrate/nitrite production. Nitrites 264-271 receptor (TNFRSF)-interacting serine-threonine kinase 2 Mus musculus 85-89 31257865-11 2019 Under these conditions, the cytochrome b5/cytochrome b5 reductase system can support a conserved role for cytoglobins through evolution, providing electrons for redox signaling reactions such as nitric oxide dioxygenation, nitrite reduction, and phospholipid oxidation. Nitrites 223-230 cytochrome b5 type A (microsomal) Danio rerio 28-41 31257865-11 2019 Under these conditions, the cytochrome b5/cytochrome b5 reductase system can support a conserved role for cytoglobins through evolution, providing electrons for redox signaling reactions such as nitric oxide dioxygenation, nitrite reduction, and phospholipid oxidation. Nitrites 223-230 cytochrome b5 type A (microsomal) Danio rerio 42-55 31308158-1 2019 Recently, Guenter Schwarz and colleagues published an elegant study in the Biochemical Journal (2019) 476, 1805-1815 which combines kinetic and spectroscopic studies with protein engineering to provide a mechanism for sulfite oxidase (SO)-catalyzed nitrite reduction that yields nitric oxide (NO). Nitrites 249-256 sulfite oxidase Homo sapiens 218-233 31308158-1 2019 Recently, Guenter Schwarz and colleagues published an elegant study in the Biochemical Journal (2019) 476, 1805-1815 which combines kinetic and spectroscopic studies with protein engineering to provide a mechanism for sulfite oxidase (SO)-catalyzed nitrite reduction that yields nitric oxide (NO). Nitrites 249-256 sulfite oxidase Homo sapiens 235-237 30417658-0 2019 Nitrite Protects Neurons Against Hypoxic Damage Through S-nitrosylation of Caspase-6. Nitrites 0-7 caspase 6 Mus musculus 75-84 30417658-7 2019 The effect of hypoxia on caspase-6 activation, microtubule disassembly, and neurite retraction was alleviated by nitrite treatment. Nitrites 113-120 caspase 6 Mus musculus 25-34 30417658-8 2019 The protective role of nitrite was further supported by the observation that the active-site Cys146 of caspase-6 was S-nitrosylated in hypoxic neuro-2a cells treated with nitrite. Nitrites 23-30 caspase 6 Mus musculus 103-112 30417658-8 2019 The protective role of nitrite was further supported by the observation that the active-site Cys146 of caspase-6 was S-nitrosylated in hypoxic neuro-2a cells treated with nitrite. Nitrites 171-178 caspase 6 Mus musculus 103-112 30417658-10 2019 Using the wild-type or Apo E-/- mice exposed to chronic hypoxia as a model, we demonstrated that supplementing drinking water with nitrite suppressed active caspase-6 in the cortex of the brain, concomitant with the prevention of hypoxia-induced anxiety in the animals. Nitrites 131-138 apolipoprotein E Mus musculus 23-28 30417658-10 2019 Using the wild-type or Apo E-/- mice exposed to chronic hypoxia as a model, we demonstrated that supplementing drinking water with nitrite suppressed active caspase-6 in the cortex of the brain, concomitant with the prevention of hypoxia-induced anxiety in the animals. Nitrites 131-138 caspase 6 Mus musculus 157-166 30417658-11 2019 Innovation: These results are the first evidence of a new pathway for the activation of caspase-6 and the first to indicate that nitrite can protect neurons against chronic hypoxic insult. Nitrites 129-136 caspase 6 Mus musculus 88-97 31167903-2 2019 Here, we report the stoichiometric reduction in nitrite to NO by human sulfite oxidase (SO), a mitochondrial intermembrane space enzyme primarily involved in cysteine catabolism. Nitrites 48-55 sulfite oxidase Homo sapiens 71-86 31167903-2 2019 Here, we report the stoichiometric reduction in nitrite to NO by human sulfite oxidase (SO), a mitochondrial intermembrane space enzyme primarily involved in cysteine catabolism. Nitrites 48-55 sulfite oxidase Homo sapiens 88-90 31167903-4 2019 In the presence of the physiological electron acceptor cytochrome c, we were able to close the catalytic cycle of sulfite-dependent nitrite reduction thus leading to steady-state NO synthesis, a finding that strongly supports a physiological relevance of SO-dependent NO formation. Nitrites 132-139 cytochrome c, somatic Homo sapiens 55-67 31167903-4 2019 In the presence of the physiological electron acceptor cytochrome c, we were able to close the catalytic cycle of sulfite-dependent nitrite reduction thus leading to steady-state NO synthesis, a finding that strongly supports a physiological relevance of SO-dependent NO formation. Nitrites 132-139 sulfite oxidase Homo sapiens 255-257 30928792-5 2019 Further analysis showed that ammonia-oxidizing bacteria (AOB) and nitrite oxidizing bacteria (NOB) in the O1 and O2 tanks together contributed to the conversion of ammonia nitrogen to nitrate, but the process of heterotrophic denitrification was inhibited in the A1 and A2 tanks because of insufficient carbon sources. Nitrites 66-73 immunoglobulin kappa variable 2D-40 Homo sapiens 106-115 31086893-4 2019 In this study, a combination of absorption and electron paramagnetic resonance spectroscopy and kinetic assays have been used to study the interaction of nitrite with the metal bound Abeta complexes. Nitrites 154-161 amyloid beta precursor protein Homo sapiens 183-188 31086893-5 2019 The data indicate that heme(III)-Cu(i)-Abeta, heme(II)-Cu(i)-Abeta, heme(II)-Abeta and Cu(i)-Abeta can reduce nitrite to nitric oxide (NO), an important biological messenger also related to AD, and thus behave as nitrite reductases. Nitrites 110-117 amyloid beta precursor protein Homo sapiens 39-44 31086893-5 2019 The data indicate that heme(III)-Cu(i)-Abeta, heme(II)-Cu(i)-Abeta, heme(II)-Abeta and Cu(i)-Abeta can reduce nitrite to nitric oxide (NO), an important biological messenger also related to AD, and thus behave as nitrite reductases. Nitrites 110-117 amyloid beta precursor protein Homo sapiens 61-66 31086893-5 2019 The data indicate that heme(III)-Cu(i)-Abeta, heme(II)-Cu(i)-Abeta, heme(II)-Abeta and Cu(i)-Abeta can reduce nitrite to nitric oxide (NO), an important biological messenger also related to AD, and thus behave as nitrite reductases. Nitrites 110-117 amyloid beta precursor protein Homo sapiens 61-66 31086893-5 2019 The data indicate that heme(III)-Cu(i)-Abeta, heme(II)-Cu(i)-Abeta, heme(II)-Abeta and Cu(i)-Abeta can reduce nitrite to nitric oxide (NO), an important biological messenger also related to AD, and thus behave as nitrite reductases. Nitrites 110-117 amyloid beta precursor protein Homo sapiens 61-66 31086893-6 2019 However these complexes reduce nitrite at different rates with heme(III)-Cu(i)-Abeta being the fastest following an inner sphere electron transfer mechanism. Nitrites 31-38 amyloid beta precursor protein Homo sapiens 79-84 31086893-7 2019 The rest of the metal-Abeta adducts follow an outer sphere electron transfer mechanism during nitrite reduction. Nitrites 94-101 amyloid beta precursor protein Homo sapiens 22-27 30943068-7 2019 siRNA knockdown of Rcn2 dramatically increased production of the nitric oxide (NO) breakdown products nitrite and nitrate by endothelial cells but not by smooth muscle cells. Nitrites 102-109 reticulocalbin 2 Mus musculus 19-23 30831514-4 2019 High initial NO2--N/NO3--N ratio enhanced denitrification rate mainly by accelerating nitrite reduction. Nitrites 86-93 NBL1, DAN family BMP antagonist Homo sapiens 20-23 31210282-13 2019 LPS + miR-124 remarkably decreased the BH4 content, nitrite level, and iNOS activity while LPS + miR-124 + GCH1 remarkably increased the BH4 content, nitrite level, and iNOS activity. Nitrites 150-157 GTP cyclohydrolase 1 Rattus norvegicus 107-111 30300060-0 2019 The Acute Effects of Mat Pilates on Hemodynamic and Salivary Nitrite Responses After Exercise in Postmenopausal Women. Nitrites 61-68 methionine adenosyltransferase 1A Homo sapiens 21-24 30602366-1 2019 OBJECTIVES: Nitrite as an alternative source of nitric oxide has been proposed, as it can mediate the protective response in the presence of ischemia or hypoxic conditions and inorganic nitrite can be reduced to nitric oxide by xanthine oxidoreductase. Nitrites 12-19 xanthine dehydrogenase Rattus norvegicus 228-251 30602366-1 2019 OBJECTIVES: Nitrite as an alternative source of nitric oxide has been proposed, as it can mediate the protective response in the presence of ischemia or hypoxic conditions and inorganic nitrite can be reduced to nitric oxide by xanthine oxidoreductase. Nitrites 186-193 xanthine dehydrogenase Rattus norvegicus 228-251 30970476-6 2019 The results showed that AOA secreted N-butyryl-dl-homoserine lactone (C4-HSL) and N-octanoyl-l-homoserine lactone (C8-HSL) to cope with nitrite accumulation, while they secreted N-(3-oxododecanoyl)-dl-homoserine lactone (OXOC12-HSL) to regulate their ammonium metabolism activity. Nitrites 136-143 lipase E, hormone sensitive type Homo sapiens 73-76 30849493-3 2019 Interestingly, our previous studies indicated that heme could bind to hIAPP, and the complex might induce the nitration of tyrosine residue (Y37) of hIAPP in the presence of hydrogen peroxide and nitrite. Nitrites 196-203 islet amyloid polypeptide Homo sapiens 70-75 30849493-3 2019 Interestingly, our previous studies indicated that heme could bind to hIAPP, and the complex might induce the nitration of tyrosine residue (Y37) of hIAPP in the presence of hydrogen peroxide and nitrite. Nitrites 196-203 islet amyloid polypeptide Homo sapiens 149-154 30849493-10 2019 The findings in this study that nitration of hIAPP promotes its oligomer formation and thus exacerbates its cytotoxicity suggests a possible link between the nitrite (or the sum of nitrite and nitrate) levels and T2D, and ameliorated nitration of hIAPP by diminishing nitrative stress might be a promising therapeutic strategy for T2D. Nitrites 158-165 islet amyloid polypeptide Homo sapiens 45-50 30849493-10 2019 The findings in this study that nitration of hIAPP promotes its oligomer formation and thus exacerbates its cytotoxicity suggests a possible link between the nitrite (or the sum of nitrite and nitrate) levels and T2D, and ameliorated nitration of hIAPP by diminishing nitrative stress might be a promising therapeutic strategy for T2D. Nitrites 181-188 islet amyloid polypeptide Homo sapiens 45-50 30900872-0 2019 Ratiometric Fluorescent Hydrogel Test Kit for On-Spot Visual Detection of Nitrite. Nitrites 74-81 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 38-41 30995881-7 2019 Tempol-treated DJ -1 -/- mice presented higher serum nitrite/nitrate levels than vehicle-treated DJ -1 -/- mice, suggesting a role of the NO system in the high blood pressure of this model. Nitrites 53-60 Parkinson disease (autosomal recessive, early onset) 7 Mus musculus 15-20 31064131-7 2019 The calibration graph for nitrites (after oxidation to nitrates) was linear in the range of 0.5-15 microg mL-1 with a correlation coefficient of 0.9972. Nitrites 26-34 L1 cell adhesion molecule Mus musculus 106-110 31064131-9 2019 The nitrate concentrations in the saliva samples were found in the range of 8.98-18.52 mug mL-1, whereas nitrite was in the range of 3.50-5.34 mug mL-1. Nitrites 105-112 L1 cell adhesion molecule Mus musculus 147-151 30995881-10 2019 The renal-selective silencing of Ucp2 led to normalization of blood pressure and serum nitrite/nitrate ratio in DJ -1 -/- mice. Nitrites 87-94 uncoupling protein 2 (mitochondrial, proton carrier) Mus musculus 33-37 30855607-1 2019 A direct NO-releasing reaction of nitrite catalyzed by [N(afaCy)3Fe(OTf)]+ (afa (azafulvene-amine); OTf (trifluoromethanesulfonate); Cy (cyclohexyl)) was investigated using density functional theory (DFT) with D3 dispersion correction. Nitrites 34-41 AFA Homo sapiens 58-61 30625591-5 2019 Under the optimized conditions, the detection limit of the proposed method was 0.06 micromol L-1 and 0.13 micromol L-1, and the linearity was up to 20 micromol L-1 and 80 micromol L-1 for nitrite and nitrate detection, respectively. Nitrites 188-195 immunoglobulin kappa variable 1-16 Homo sapiens 93-96 30625591-5 2019 Under the optimized conditions, the detection limit of the proposed method was 0.06 micromol L-1 and 0.13 micromol L-1, and the linearity was up to 20 micromol L-1 and 80 micromol L-1 for nitrite and nitrate detection, respectively. Nitrites 188-195 immunoglobulin kappa variable 1-16 Homo sapiens 115-118 30625591-5 2019 Under the optimized conditions, the detection limit of the proposed method was 0.06 micromol L-1 and 0.13 micromol L-1, and the linearity was up to 20 micromol L-1 and 80 micromol L-1 for nitrite and nitrate detection, respectively. Nitrites 188-195 immunoglobulin kappa variable 1-16 Homo sapiens 115-118 30625591-5 2019 Under the optimized conditions, the detection limit of the proposed method was 0.06 micromol L-1 and 0.13 micromol L-1, and the linearity was up to 20 micromol L-1 and 80 micromol L-1 for nitrite and nitrate detection, respectively. Nitrites 188-195 immunoglobulin kappa variable 1-16 Homo sapiens 115-118 29283317-2 2019 Results showed that 20 mg L-1 quinoline addition leading the ammonia and nitrite removal efficiency of the ABR reduced from about 90% to 40%. Nitrites 73-80 immunoglobulin kappa variable 1-16 Homo sapiens 26-29 30961671-7 2019 Methemoglobin-forming agents (e.g., nitrites, dimethylaminophenol) or hydroxocobalamin (Vitamin B12) are options. Nitrites 36-44 hemoglobin subunit gamma 2 Homo sapiens 0-13 30796298-6 2019 Herein, carbon screen-printed electrodes were modified with cytochrome c nitrite reductase together with glucose oxidase and catalase, so that nitrite cathodic detection could be performed by cyclic voltammetry under ambient air. Nitrites 73-80 cytochrome c, somatic Homo sapiens 60-72 30884848-1 2019 Nitrate reductase (NR) is important for higher land plants, as it catalyzes the rate-limiting step in the nitrate assimilation pathway, the two-electron reduction of nitrate to nitrite. Nitrites 177-184 nitrate reductase 1 Arabidopsis thaliana 0-17 30234781-13 2019 CONCLUSION: Our results demonstrated that altered expression of imprinted genes DLK1 and MEG3 were caused by hypermethylation of IG-DMR in HUVEC of preeclampsia group, accompanied by lower secretion of nitrite, VEGF, and higher secretion of ET1. Nitrites 202-209 delta like non-canonical Notch ligand 1 Homo sapiens 80-84 30234781-13 2019 CONCLUSION: Our results demonstrated that altered expression of imprinted genes DLK1 and MEG3 were caused by hypermethylation of IG-DMR in HUVEC of preeclampsia group, accompanied by lower secretion of nitrite, VEGF, and higher secretion of ET1. Nitrites 202-209 maternally expressed 3 Homo sapiens 89-93 30234781-13 2019 CONCLUSION: Our results demonstrated that altered expression of imprinted genes DLK1 and MEG3 were caused by hypermethylation of IG-DMR in HUVEC of preeclampsia group, accompanied by lower secretion of nitrite, VEGF, and higher secretion of ET1. Nitrites 202-209 vascular endothelial growth factor A Homo sapiens 211-215 30234781-13 2019 CONCLUSION: Our results demonstrated that altered expression of imprinted genes DLK1 and MEG3 were caused by hypermethylation of IG-DMR in HUVEC of preeclampsia group, accompanied by lower secretion of nitrite, VEGF, and higher secretion of ET1. Nitrites 202-209 endothelin 1 Homo sapiens 241-244 30249372-5 2019 With 100% of the sludge treated every 12 h at a treatment energy input of 0.066 kJ per mg mixed liquor suspended solids, the nitrite pathway was rapidly (within two weeks) established in the experimental reactor with stable effluent nitrite accumulation ratio (NO2-/(NO2- + NO3-)) of above 80% and significantly decreased NOB population. Nitrites 125-132 NBL1, DAN family BMP antagonist Homo sapiens 274-277 30585477-3 2019 Here we demonstrate that IDO1 is a mammalian nitrite reductase capable of chemically reducing nitrite to nitric oxide (NO) under hypoxia. Nitrites 45-52 indoleamine 2,3-dioxygenase 1 Homo sapiens 25-29 30585477-4 2019 Ultraviolet-visible absorption and resonance Raman spectroscopy showed that incubation of dithionite-reduced, ferrous-IDO1 protein (FeII-IDO1) with nitrite under anaerobic conditions resulted in the time-dependent formation of an FeII-nitrosyl IDO1 species, which was inhibited by substrate l-tryptophan, dependent on the concentration of nitrite or IDO1, and independent of the concentration of the reductant, dithionite. Nitrites 148-155 indoleamine 2,3-dioxygenase 1 Homo sapiens 118-122 30585477-4 2019 Ultraviolet-visible absorption and resonance Raman spectroscopy showed that incubation of dithionite-reduced, ferrous-IDO1 protein (FeII-IDO1) with nitrite under anaerobic conditions resulted in the time-dependent formation of an FeII-nitrosyl IDO1 species, which was inhibited by substrate l-tryptophan, dependent on the concentration of nitrite or IDO1, and independent of the concentration of the reductant, dithionite. Nitrites 148-155 indoleamine 2,3-dioxygenase 1 Homo sapiens 137-141 30585477-4 2019 Ultraviolet-visible absorption and resonance Raman spectroscopy showed that incubation of dithionite-reduced, ferrous-IDO1 protein (FeII-IDO1) with nitrite under anaerobic conditions resulted in the time-dependent formation of an FeII-nitrosyl IDO1 species, which was inhibited by substrate l-tryptophan, dependent on the concentration of nitrite or IDO1, and independent of the concentration of the reductant, dithionite. Nitrites 148-155 indoleamine 2,3-dioxygenase 1 Homo sapiens 137-141 30585477-4 2019 Ultraviolet-visible absorption and resonance Raman spectroscopy showed that incubation of dithionite-reduced, ferrous-IDO1 protein (FeII-IDO1) with nitrite under anaerobic conditions resulted in the time-dependent formation of an FeII-nitrosyl IDO1 species, which was inhibited by substrate l-tryptophan, dependent on the concentration of nitrite or IDO1, and independent of the concentration of the reductant, dithionite. Nitrites 148-155 indoleamine 2,3-dioxygenase 1 Homo sapiens 137-141 30585477-4 2019 Ultraviolet-visible absorption and resonance Raman spectroscopy showed that incubation of dithionite-reduced, ferrous-IDO1 protein (FeII-IDO1) with nitrite under anaerobic conditions resulted in the time-dependent formation of an FeII-nitrosyl IDO1 species, which was inhibited by substrate l-tryptophan, dependent on the concentration of nitrite or IDO1, and independent of the concentration of the reductant, dithionite. Nitrites 339-346 indoleamine 2,3-dioxygenase 1 Homo sapiens 118-122 30585477-4 2019 Ultraviolet-visible absorption and resonance Raman spectroscopy showed that incubation of dithionite-reduced, ferrous-IDO1 protein (FeII-IDO1) with nitrite under anaerobic conditions resulted in the time-dependent formation of an FeII-nitrosyl IDO1 species, which was inhibited by substrate l-tryptophan, dependent on the concentration of nitrite or IDO1, and independent of the concentration of the reductant, dithionite. Nitrites 339-346 indoleamine 2,3-dioxygenase 1 Homo sapiens 137-141 30585477-4 2019 Ultraviolet-visible absorption and resonance Raman spectroscopy showed that incubation of dithionite-reduced, ferrous-IDO1 protein (FeII-IDO1) with nitrite under anaerobic conditions resulted in the time-dependent formation of an FeII-nitrosyl IDO1 species, which was inhibited by substrate l-tryptophan, dependent on the concentration of nitrite or IDO1, and independent of the concentration of the reductant, dithionite. Nitrites 339-346 indoleamine 2,3-dioxygenase 1 Homo sapiens 137-141 30585477-4 2019 Ultraviolet-visible absorption and resonance Raman spectroscopy showed that incubation of dithionite-reduced, ferrous-IDO1 protein (FeII-IDO1) with nitrite under anaerobic conditions resulted in the time-dependent formation of an FeII-nitrosyl IDO1 species, which was inhibited by substrate l-tryptophan, dependent on the concentration of nitrite or IDO1, and independent of the concentration of the reductant, dithionite. Nitrites 339-346 indoleamine 2,3-dioxygenase 1 Homo sapiens 137-141 30706062-8 2019 The applicability of this method was further demonstrated by stacking and separation of copper ions/nitrite and even amphoteric ions-proteins of phycocyanin (blue, pI 4.4)/cytochrome C (brown, pI 10.2). Nitrites 100-107 cytochrome c, somatic Homo sapiens 172-184 30624978-9 2019 Plasma nitrate-nitrite levels increased in IL-4-treated RUPP rats, while placental preproendothelin-1 expression, plasma TNF-alpha and IL-6, and AT1-AA decreased in IL-4-treated RUPP rats compared with untreated RUPP rats ( P < 0.05). Nitrites 15-22 interleukin 4 Rattus norvegicus 43-47 30603848-12 2019 Model results reveal that when nitrite concentration (SNO2-) is higher than nitrite affinity constant (KNO2-), salinity (over ~ 3.0%) is responsible for Candidatus Scalindua dominance over Candidatus Kuenenia. Nitrites 76-83 ADAM metallopeptidase with thrombospondin type 1 motif 18 Homo sapiens 103-107 30603848-13 2019 Conversely, in nitrite-depleted conditions (KNO2- >= SNO2-), high nitrite affinity leads to the predominance of Ca. Nitrites 15-22 ADAM metallopeptidase with thrombospondin type 1 motif 18 Homo sapiens 44-48 30603848-13 2019 Conversely, in nitrite-depleted conditions (KNO2- >= SNO2-), high nitrite affinity leads to the predominance of Ca. Nitrites 69-76 ADAM metallopeptidase with thrombospondin type 1 motif 18 Homo sapiens 44-48 30551041-1 2019 In this study, the synergy of high nitrite (NO2--N) accumulated partial-denitrification (PD) and anammox in a continuously fed upflow anaerobic sludge blanket (UASB) reactor was verified for simultaneous nitrate (NO3--N) and ammonia (NH4+-N) removal. Nitrites 35-42 NBL1, DAN family BMP antagonist Homo sapiens 213-216 30777103-4 2019 METHODS: The influences of endogenous and exogenous H2S on the expression of IDO1, iNOS and NF-kappaB and STAT3 signaling proteins were investigated using qPCR or western blot, and the production of nitric oxide (NO) was analyzed by nitrate/nitrite assay in Cse-/- mice and MCF-7 and SGC-7901 cells. Nitrites 241-248 histocompatibility 2, S region (C4, Slp, Bf, C2) Mus musculus 52-55 30559212-6 2019 In a human liver cell line (HepG2) and in a validated hepatic 3D model with primary human hepatocyte spheroids, nitrite treatment reduced the degree of metabolically induced steatosis (i.e., high glucose, insulin, and free fatty acids), as well as drug-induced steatosis (i.e., amiodarone). Nitrites 112-119 insulin Homo sapiens 205-212 30559212-7 2019 Mechanistically, the salutary metabolic effects of nitrate and nitrite can be ascribed to nitrite-derived formation of NO species and activation of soluble guanylyl cyclase, where xanthine oxidoreductase is proposed to mediate the reduction of nitrite. Nitrites 63-70 xanthine dehydrogenase Homo sapiens 180-203 30399409-0 2019 Nitrite treatment downregulates vascular MMP-2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects. Nitrites 0-7 matrix metallopeptidase 2 Rattus norvegicus 41-46 30576115-6 2019 A hypothesis has been presented as to why cytochrome c containing nitrite reductases and cytochrome cd1 containing nitrite reductases follow different mechanistic pathways of nitrite reduction. Nitrites 66-73 cytochrome c, somatic Homo sapiens 42-54 29529688-7 2019 RESULTS: The mean concentration of myeloperoxidase was significantly higher in the diabetic group compared to the control group (16.2+-4.9 vs. 3.7+-1.8; P<0.001).The nitrite concentration was comparable in both groups while the concentration of nitrate was significantly higher in the diabetic group (41.2 [42.9] vs 31.9 [23]; P=0.017). Nitrites 169-176 myeloperoxidase Homo sapiens 35-50 30399409-2 2019 Given that impaired redox state activates matrix metalloproteinase (MMP)- 2 and promotes vascular remodeling, we hypothesized that nitrite treatment at a non-antihypertensive dose exerts antioxidant effects and attenuates both MMP-2 activation and vascular remodeling of hypertension. Nitrites 131-138 matrix metallopeptidase 2 Rattus norvegicus 42-75 30399409-2 2019 Given that impaired redox state activates matrix metalloproteinase (MMP)- 2 and promotes vascular remodeling, we hypothesized that nitrite treatment at a non-antihypertensive dose exerts antioxidant effects and attenuates both MMP-2 activation and vascular remodeling of hypertension. Nitrites 131-138 matrix metallopeptidase 2 Rattus norvegicus 227-232 30399409-11 2019 This effect was fully inhibited by the xanthine oxidase (XOR) inhibitor febuxostat, suggesting XOR-mediated generation of nitric oxide (NO) from nitrite as a mechanism explaining the responses to nitrite. Nitrites 145-152 xanthine dehydrogenase Rattus norvegicus 57-60 30399409-11 2019 This effect was fully inhibited by the xanthine oxidase (XOR) inhibitor febuxostat, suggesting XOR-mediated generation of nitric oxide (NO) from nitrite as a mechanism explaining the responses to nitrite. Nitrites 145-152 xanthine dehydrogenase Rattus norvegicus 95-98 30399409-11 2019 This effect was fully inhibited by the xanthine oxidase (XOR) inhibitor febuxostat, suggesting XOR-mediated generation of nitric oxide (NO) from nitrite as a mechanism explaining the responses to nitrite. Nitrites 196-203 xanthine dehydrogenase Rattus norvegicus 57-60 30399409-11 2019 This effect was fully inhibited by the xanthine oxidase (XOR) inhibitor febuxostat, suggesting XOR-mediated generation of nitric oxide (NO) from nitrite as a mechanism explaining the responses to nitrite. Nitrites 196-203 xanthine dehydrogenase Rattus norvegicus 95-98 30399409-14 2019 This response is mediated, at least in part, by XOR and is attributable to antioxidant effects of nitrite blunting vascular MMP-2 activation. Nitrites 98-105 xanthine dehydrogenase Rattus norvegicus 48-51 30526064-8 2019 Arginase-1 was negatively correlated with serum nitrite and nitrate (r = -0.8137 and r = -0.8444, respectively). Nitrites 48-55 arginase 1 Homo sapiens 0-10 30399409-14 2019 This response is mediated, at least in part, by XOR and is attributable to antioxidant effects of nitrite blunting vascular MMP-2 activation. Nitrites 98-105 matrix metallopeptidase 2 Rattus norvegicus 124-129 30545001-6 2018 For the NHC reduction, mARC uses cytochrome b5 and cytochrome b5 reductase, however for the nitrite reduction, plant mARC uses NR. Nitrites 92-99 cytochrome b5 type A Homo sapiens 33-46 30625496-7 2019 In addition, overexpression of miR-183/96/182 results in decreased production of nitrite and ROS in Raw264.7 cells. Nitrites 81-88 microRNA 183 Mus musculus 31-38 30545001-6 2018 For the NHC reduction, mARC uses cytochrome b5 and cytochrome b5 reductase, however for the nitrite reduction, plant mARC uses NR. Nitrites 92-99 cytochrome b5 type A Homo sapiens 51-64 30335579-12 2018 NEW & NOTEWORTHY A single hot water immersion (HWI) session induces an acute increase in plasma interleukin-6 and nitrite concentrations but does not acutely elevate heat shock protein-72 expression in monocytes [intracellular Hsp72 (iHsp72)]. Nitrites 118-125 alcohol dehydrogenase iron containing 1 Homo sapiens 30-33 30513985-3 2018 Remarkable increases in malondialdehyde (MDA) levels have suggested that nitrite and/or MC-LR exposures induce oxidative stress in fish spleen, which were indirectly confirmed by significant downregulations of total antioxidant capacity (T-AOC), glutathione (GSH) contents, as well as transcriptional levels of antioxidant enzyme genes cat1, sod1 and gpx1a. Nitrites 73-80 superoxide dismutase 1, soluble Danio rerio 342-346 30513985-3 2018 Remarkable increases in malondialdehyde (MDA) levels have suggested that nitrite and/or MC-LR exposures induce oxidative stress in fish spleen, which were indirectly confirmed by significant downregulations of total antioxidant capacity (T-AOC), glutathione (GSH) contents, as well as transcriptional levels of antioxidant enzyme genes cat1, sod1 and gpx1a. Nitrites 73-80 glutathione peroxidase 1a Danio rerio 351-356 30513985-4 2018 Simultaneously, nitrite and MC-LR significantly decreased serum complement C3 levels as well as the transcriptional levels of splenic c3b, lyz, il1beta, ifngamma and tnfalpha, and indicated that they could jointly impact the innate immunity of fish. Nitrites 16-23 complement C3 Danio rerio 64-77 30513985-4 2018 Simultaneously, nitrite and MC-LR significantly decreased serum complement C3 levels as well as the transcriptional levels of splenic c3b, lyz, il1beta, ifngamma and tnfalpha, and indicated that they could jointly impact the innate immunity of fish. Nitrites 16-23 complement C3a, tandem duplicate 2 Danio rerio 134-137 30513985-4 2018 Simultaneously, nitrite and MC-LR significantly decreased serum complement C3 levels as well as the transcriptional levels of splenic c3b, lyz, il1beta, ifngamma and tnfalpha, and indicated that they could jointly impact the innate immunity of fish. Nitrites 16-23 lysozyme Danio rerio 139-142 30513985-4 2018 Simultaneously, nitrite and MC-LR significantly decreased serum complement C3 levels as well as the transcriptional levels of splenic c3b, lyz, il1beta, ifngamma and tnfalpha, and indicated that they could jointly impact the innate immunity of fish. Nitrites 16-23 tumor necrosis factor a (TNF superfamily, member 2) Danio rerio 166-174 30339375-7 2018 In the presence of O2, both 5 and 6 transform to nitrite-bound monomers [(LMe(S-S))Ni(NO2)](ClO4) (7) and [(LBr(S-S))Ni(NO2)](ClO4)2 (8). Nitrites 49-56 lamin B receptor Homo sapiens 108-111 30450436-3 2018 Nitrate plus nitrite (NO3 + NO2) dominated TN species in urban/CAFO-influenced streams. Nitrites 13-20 NBL1, DAN family BMP antagonist Homo sapiens 22-25 30713473-7 2018 Our results showed that CsA (1 nM, 10 nM, and 100 nM) and CAIP (50 microM) have significantly reduced cAMP and nitrite levels as compared to MOR-treated (2.5 microM) T98G cells. Nitrites 111-118 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 24-27 30335864-0 2018 Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults. Nitrites 115-122 nitric oxide synthase 3 Homo sapiens 15-48 30257378-5 2018 Administration of CCl4 to rat decreased (p < 0.01) the level of catalase (CAT), total superoxide dismutase (SOD), peroxidase (POD), soluble protein and reduced glutathione (GSH) whereas elevated the concentration of H2O2, thiobarbituric acid reactive substances and nitrite in hepatic samples. Nitrites 269-276 C-C motif chemokine ligand 4 Rattus norvegicus 18-22 30295311-7 2018 In addition, this paper-based sensor has been successfully employed to determine the nitrite content in tap, river and lake water samples. Nitrites 85-92 nuclear RNA export factor 1 Homo sapiens 104-107 29744767-0 2018 Poppers and PrEP: Use of Pre-exposure Prophylaxis Among Men Who Have Sex with Men Who Use Inhaled Nitrites. Nitrites 98-106 prolyl endopeptidase Homo sapiens 12-16 30223329-4 2018 Concurrently, exposure to MC-LR or nitrite alone could significantly decrease T levels by downregulating gene expressions (gnrh2, lhbeta, ar, lhr) in the hypothalamic-pituitary-gonadal-liver-axis (HPGL-axis), and there were significant interactions between MC-LR and nitrite on them. Nitrites 35-42 luteinizing hormone subunit beta Danio rerio 130-136 30179715-0 2018 Nitrite mediated vasorelaxation in human chorionic plate vessels is enhanced by hypoxia and dependent on the NO-sGC-cGMP pathway. Nitrites 0-7 sarcoglycan beta Homo sapiens 112-115 30179715-5 2018 Reduction of nitrite to NO may be particularly relevant in tissue when the oxygen-dependent NO synthase (NOS) activity is compromised, e.g. in hypoxia. Nitrites 13-20 nitric oxide synthase 2 Homo sapiens 92-103 30281301-2 2018 The aim of this study was to compare nitrite with S-nitrosocysteine (Cys-SNO) and S-nitroso-N-acetylcysteine (NAC-SNO) with respect to N-NA formation, which was evaluated by determining the conversion of N-methylaniline to N-nitrosomethylaniline. Nitrites 37-44 strawberry notch homolog 1 Homo sapiens 73-76 30281301-3 2018 Under neutral and acidic pH conditions, N-NA formation rate was nitrite > Cys-SNO > NAC-SNO. Nitrites 64-71 strawberry notch homolog 1 Homo sapiens 81-84 30281301-3 2018 Under neutral and acidic pH conditions, N-NA formation rate was nitrite > Cys-SNO > NAC-SNO. Nitrites 64-71 synuclein alpha Homo sapiens 90-93 30281301-3 2018 Under neutral and acidic pH conditions, N-NA formation rate was nitrite > Cys-SNO > NAC-SNO. Nitrites 64-71 strawberry notch homolog 1 Homo sapiens 94-97 30281301-7 2018 In heated meat, Cys-SNO and NAC-SNO generated the nitrosyl-hemochrome pink pigment, better than nitrite. Nitrites 96-103 synuclein alpha Homo sapiens 28-31 30335864-5 2018 Thus, this study aimed to investigate the association of eNOS gene haplotypes and different levels of TS on nitrite concentrations (NO2-) and BP values in older adult. Nitrites 108-115 nitric oxide synthase 3 Homo sapiens 57-61 30092374-10 2018 LPA also increased the total nitrite level in tissue homogenates in LPAR1/3- and iNOS-dependent manner. Nitrites 29-36 lysophosphatidic acid receptor 1 Homo sapiens 68-73 30170003-7 2018 The results showing that NTP irradiation of the lactate solution rather than the inorganic salt solution induced the inactivation of catalase were dependent on the presence or absence of nitrite in these solutions. Nitrites 187-194 catalase Homo sapiens 133-141 30092374-10 2018 LPA also increased the total nitrite level in tissue homogenates in LPAR1/3- and iNOS-dependent manner. Nitrites 29-36 inositol-3-phosphate synthase 1 Homo sapiens 81-85 30235277-2 2018 Although hemoglobin E (HbE) solutions have been shown to exhibit decreased rate of nitrite reduction to NO, this observation has never been reported in erythrocytes from subjects with hemoglobin E/ss-thalassemia (HbE/ss-thal). Nitrites 83-90 hemoglobin subunit epsilon 1 Homo sapiens 9-21 29906753-2 2018 In this study, the ratio of S2O32--S/NO3--N and pH are confirmed to be two key factors affecting the thiosulfate-driven denitratation activity and nitrite accumulation. Nitrites 147-154 NBL1, DAN family BMP antagonist Homo sapiens 37-40 29906753-3 2018 Simultaneous high denitratation activity and substantial nitrite accumulation were observed at initial S2O32--S/NO3--N ratio of 1.5:1 and pH of 8.0. Nitrites 57-64 NBL1, DAN family BMP antagonist Homo sapiens 112-115 29906753-7 2018 At HRT of 30 min, the NO3- removal efficiency could achieve above 90% with the nitrate-to-nitrite transformation ratio of 0.8, implying the great potential to apply the thiosulfate-driven denitratation & anammox system for BNR with minimal sludge production. Nitrites 90-97 NBL1, DAN family BMP antagonist Homo sapiens 22-25 30196191-0 2018 Putting xanthine oxidoreductase and aldehyde oxidase on the NO metabolism map: Nitrite reduction by molybdoenzymes. Nitrites 79-86 xanthine dehydrogenase Homo sapiens 8-31 30196191-0 2018 Putting xanthine oxidoreductase and aldehyde oxidase on the NO metabolism map: Nitrite reduction by molybdoenzymes. Nitrites 79-86 aldehyde oxidase 1 Homo sapiens 36-52 30235277-2 2018 Although hemoglobin E (HbE) solutions have been shown to exhibit decreased rate of nitrite reduction to NO, this observation has never been reported in erythrocytes from subjects with hemoglobin E/ss-thalassemia (HbE/ss-thal). Nitrites 83-90 hemoglobin subunit epsilon 1 Homo sapiens 23-26 30235277-5 2018 HbNO produced from the reaction of nitrite with deoxyHb dialysate from both non-splenectomized and splenectomized HbE/ss-thal subjects was lower than that of normal (AA) hemoglobin subjects. Nitrites 35-42 hemoglobin subunit epsilon 1 Homo sapiens 114-117 30235277-7 2018 HbNO formation from the reactions of nitrite and deoxyHb inversely correlated with baseline platelet P-selectin expression, HbE levels, and tricuspid regurgitant velocity (TRV). Nitrites 37-44 selectin P Homo sapiens 101-111 30235277-7 2018 HbNO formation from the reactions of nitrite and deoxyHb inversely correlated with baseline platelet P-selectin expression, HbE levels, and tricuspid regurgitant velocity (TRV). Nitrites 37-44 hemoglobin subunit epsilon 1 Homo sapiens 124-127 30235277-8 2018 Nitrite plus deoxygenated erythrocytes from HbE/ss-thal subjects had a lower ability to inhibit ADP-induced P-selectin expression on platelets than erythrocytes from normal subjects. Nitrites 0-7 selectin P Homo sapiens 108-118 30235277-9 2018 We conclude that deoxyHb in erythrocytes from HbE/ss-thal subjects has a decreased ability to reduce nitrite to NO, which is correlated with increased platelet activity in these individuals. Nitrites 101-108 hemoglobin subunit epsilon 1 Homo sapiens 46-49 30229313-5 2018 Prior studies show how nitrites and nitrates in red meat can lead to increased insulin resistance, dysregulated blood glucose levels, and elevated oxidative stress all leading to chronic diseases. Nitrites 23-31 insulin Homo sapiens 79-86 30294630-8 2018 Although, the average concentration of NO3- and NO2- in drinking water was lower than the national standard limits, but the non-carcinogenic risk assessment showed that the children and adults are at a significant risk via nitrate and nitrite in the rural Divandarreh County (TTHQ > 1). Nitrites 235-242 NBL1, DAN family BMP antagonist Homo sapiens 39-42 30021348-5 2018 In hepatic sample of rat, CCl4 administration increased (p < 0.05) the level of nitrite, hydrogen peroxide (H2O2), thiobarbituric acid reactive substances (TBARS) whereas a decline was recorded in antioxidant enzymes; superoxide dismutase (SOD), peroxidase (POD), catalase (CAT) and in reduced glutathione (GSH). Nitrites 83-90 C-C motif chemokine ligand 4 Rattus norvegicus 26-30 30131697-9 2018 The endothelial nitric oxide synthase (eNOS) protein and myocardial nitrate/nitrite were impaired in the heart of diabetic rats, which, however, were restored after PKK treatment. Nitrites 76-83 kallikrein 1-related peptidase B3 Rattus norvegicus 165-168 30002061-9 2018 CSE-/- mice showed elevated vascular nitrite levels (measure of nitric oxide [NO]) in the unligated carotids, suggesting an elevation in baseline NO production, and the NO scavenger 2-(4-carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazolyl-1-oxy-3-oxide normalized the reduced inward remodeling, but not inflammation, of ligated carotids in CSE-/- mice. Nitrites 37-44 cystathionase (cystathionine gamma-lyase) Mus musculus 0-3 30016730-9 2018 Additionaly, PSAP reduced nitrite and malondialdehyde (MDA) levels and catalase (CAT) activity in the cerebral cortex and hippocampus of reserpinised mice. Nitrites 26-33 prosaposin Mus musculus 13-17 30135317-0 2018 Oral nitrite restores age-dependent phenotypes in eNOS-null mice. Nitrites 5-12 nitric oxide synthase 3, endothelial cell Mus musculus 50-54 30135317-6 2018 Treatment of 4-month-old eNOS-/- mice with nitrite for 10 days corrected the hypertension and serum hyperlipidemia and normalized the rate of fatty acid oxidation. Nitrites 43-50 nitric oxide synthase 3, endothelial cell Mus musculus 25-29 30135317-8 2018 Seven-month administration of nitrite to eNOS-/- mice reversed the age-dependent metabolic derangements and restored physical activity. Nitrites 30-37 nitric oxide synthase 3, endothelial cell Mus musculus 41-45 30111761-2 2018 In Finland, tap water is the main source of drinking water, and thus the nitrite in tap water increases nitrite exposure. Nitrites 73-80 nuclear RNA export factor 1 Homo sapiens 12-15 30111761-2 2018 In Finland, tap water is the main source of drinking water, and thus the nitrite in tap water increases nitrite exposure. Nitrites 73-80 nuclear RNA export factor 1 Homo sapiens 84-87 30111761-2 2018 In Finland, tap water is the main source of drinking water, and thus the nitrite in tap water increases nitrite exposure. Nitrites 104-111 nuclear RNA export factor 1 Homo sapiens 12-15 30111761-2 2018 In Finland, tap water is the main source of drinking water, and thus the nitrite in tap water increases nitrite exposure. Nitrites 104-111 nuclear RNA export factor 1 Homo sapiens 84-87 30338117-1 2018 Objectives: Plasma nitrite is a metabolite of nitric oxide and reflects endogenous nitric oxide synthase (NOS) activity. Nitrites 19-26 nitric oxide synthase 2 Homo sapiens 83-104 29659727-9 2018 Nitrite circumvented platelet NO resistance independently of other blood cells by directly activating sGC and phosphorylating VASP. Nitrites 0-7 vasodilator stimulated phosphoprotein Homo sapiens 126-130 29792932-4 2018 After culturing macrophages in the presence of LPS for 24-48 h, nitrite levels in the medium of xCT-deficient macrophages were significantly decreased compared to that of wild-type cells. Nitrites 64-71 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 Mus musculus 96-99 29792932-7 2018 When xCT-deficient macrophages were cultured with 2-mercaptoethanol, intracellular cysteine levels were increased and nitrite accumulation in the medium was significantly increased. Nitrites 118-125 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 Mus musculus 5-8 29734055-7 2018 Inhibiting KMO with Ro 61-8048 during LPS challenge attenuated extracellular nitrite accumulation and expression of KMO and TNF-alpha in response to LPS. Nitrites 77-84 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 11-14 29771512-3 2018 Here, we show that the ATP-dependent enzyme CreM installs the diazo group in cremeomycin via late-stage N-N bond formation using nitrite. Nitrites 129-136 cAMP responsive element modulator Homo sapiens 44-48 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. Nitrites 134-141 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 29702417-5 2018 This method has been successfully applied to the determination of nitrites in tap water, lake water and Yellow River water with recoveries in the range of 94.8%-105.4%. Nitrites 66-74 nuclear RNA export factor 1 Homo sapiens 78-81 29702279-12 2018 HO-1 played important roles in the down-regulation of superoxide levels in lung tissues by cordycepin, and HO-1 expression induced by cordycepin affected nitrite and nitrate concentrations in plasma and iNOS protein expression in lung tissues. Nitrites 154-161 heme oxygenase 1 Rattus norvegicus 107-111 29728915-3 2018 Isolated human and bovine erythrocytic CAII and CAIV can convert nitrite to nitrous acid (HONO) and its anhydride N2O3 which, in the presence of thiols (RSH), are further converted to S-nitrosothiols (RSNO) and NO. Nitrites 65-72 carbonic anhydrase 2 Bos taurus 39-43 29728915-3 2018 Isolated human and bovine erythrocytic CAII and CAIV can convert nitrite to nitrous acid (HONO) and its anhydride N2O3 which, in the presence of thiols (RSH), are further converted to S-nitrosothiols (RSNO) and NO. Nitrites 65-72 carbonic anhydrase 4 Bos taurus 48-52 29736649-2 2018 The nitrite and nitrate in drinking water had a concentration range of 0.030-0.113 and 2.41-8.70 mg L-1, with mean values of 0.059 +- 0.014 and 5.25 +- 1.61 mg L-1, respectively. Nitrites 4-11 immunoglobulin kappa variable 1-16 Homo sapiens 100-103 29736649-2 2018 The nitrite and nitrate in drinking water had a concentration range of 0.030-0.113 and 2.41-8.70 mg L-1, with mean values of 0.059 +- 0.014 and 5.25 +- 1.61 mg L-1, respectively. Nitrites 4-11 immunoglobulin kappa variable 1-16 Homo sapiens 160-163 29578055-12 2018 Serum nitrite levels correlated with the serum BNP levels. Nitrites 6-13 natriuretic peptide B Homo sapiens 47-50 29588193-7 2018 Nitrite levels indicated fast NO release (due to the molecule) and delayed (1-6 h) NO production linked to PI-3K/Akt-dependent eNOS activation. Nitrites 0-7 AKT serine/threonine kinase 1 Homo sapiens 113-116 29955103-6 2018 After APP treatment, nitrite was produced in myoglobin solution that provided a positive environment for nitrimyoglobin formation. Nitrites 21-28 myoglobin Homo sapiens 45-54 29680657-12 2018 Plasma nitrite and HMGB1 levels were significantly higher than those in the sham controls, and the elevated levels were significantly lowered in the presence of 1400 W. We concluded that the S-nitrosylation of Sirt1 under endotoxic conditions may uninhibit the acetylation of HMGB1 and its extracellular release. Nitrites 7-14 sirtuin 1 Mus musculus 210-215 29870054-2 2018 Nitrite levels, which are regulated by inducible nitric oxide synthase (iNOS), play a critical role in inflammation. Nitrites 0-7 nitric oxide synthase 2 Rattus norvegicus 39-70 29870054-2 2018 Nitrite levels, which are regulated by inducible nitric oxide synthase (iNOS), play a critical role in inflammation. Nitrites 0-7 nitric oxide synthase 2 Rattus norvegicus 72-76 29668882-0 2018 Hopanoid-producing bacteria in the Red Sea include the major marine nitrite oxidizers. Nitrites 68-75 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 39-42 29668882-5 2018 The distributions of hopanoid production and nitrite oxidation genes in the Red Sea are closely correlated, and the majority of hopanoid producers are taxonomically affiliated with the major marine nitrite oxidizers, Nitrospinae and Nitrospirae. Nitrites 45-52 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 80-83 29534920-9 2018 TGF-beta correlated directly with nitrite and nitrate and inversely to other inflammatory factors. Nitrites 34-41 transforming growth factor beta 1 Homo sapiens 0-8 29431233-6 2018 The percentage of functional membrane sperm treated with Lf was higher (50.7% +- 11.6%) compared to that of the control (37.6% +- 15.6%), while the iron (61.4 +- 11.6 vs 73.3 +- 13.8 mg/dl) and nitrite concentrations (16.3 +- 7.1 vs 25.9 +- 4.2 muM/mug protein) were lower, respectively (p < .05). Nitrites 194-201 lactotransferrin Equus caballus 57-59 29442870-6 2018 In tests, the NiO/MWCNTs/CP shown a sensitive current response toward nitrite, the oxidation peak current are linearly related to nitrite concentration in the range from 10-6 M to 10-4 M (R = 0.997) with a sensitivity of 3.53 muA muM-1 and a detection limit of 0.25 muM (S/N = 3). Nitrites 70-77 PWWP domain containing 3A, DNA repair factor Homo sapiens 230-235 29530793-0 2018 Nitrite exerts antioxidant effects, inhibits the mTOR pathway and reverses hypertension-induced cardiac hypertrophy. Nitrites 0-7 mechanistic target of rapamycin kinase Rattus norvegicus 49-53 29530793-9 2018 This nitrite dose also blunted hypertension-induced activation of mTOR pathway and cardiac hypertrophy. Nitrites 5-12 mechanistic target of rapamycin kinase Rattus norvegicus 66-70 29530793-10 2018 While the lower nitrite dose (1 mg/kg) did not affect blood pressure, it exerted antioxidant effects and tended to attenuate mTOR pathway activation and cardiac hypertrophy induced by hypertension. Nitrites 16-23 mechanistic target of rapamycin kinase Rattus norvegicus 125-129 29530793-11 2018 Our findings provide strong evidence that nitrite treatment decreases cardiac remodeling induced by hypertension as a result of its antioxidant effects and downregulation of mTOR signaling pathway. Nitrites 42-49 mechanistic target of rapamycin kinase Rattus norvegicus 174-178 29442870-6 2018 In tests, the NiO/MWCNTs/CP shown a sensitive current response toward nitrite, the oxidation peak current are linearly related to nitrite concentration in the range from 10-6 M to 10-4 M (R = 0.997) with a sensitivity of 3.53 muA muM-1 and a detection limit of 0.25 muM (S/N = 3). Nitrites 130-137 PWWP domain containing 3A, DNA repair factor Homo sapiens 230-235 29473818-1 2018 Nitro-conjugated linoleic acid (NO2-CLA) is formed by metabolic and inflammatory reactions of nitric oxide and nitrite, and represents the most abundant nitro-fatty acid species in humans. Nitrites 111-118 selectin P ligand Homo sapiens 36-39 29438701-8 2018 SL-CLP enhanced nitrate/nitrite (NOx) concentrations in the MAB of WT, but not iNOS-deficient mice. Nitrites 24-31 leucine-rich repeat LGI family, member 4 Mus musculus 3-6 29396380-7 2018 We demonstrated an increased expression of eNOs in myocardial tissue the heightening of nitrite concentration, accompanied with upregulation of proangiogenic growth factors and myocardium related mRNA. Nitrites 88-95 nitric oxide synthase 3 Rattus norvegicus 43-47 29657937-10 2018 In RDN model, the serum nitrite levels were decreased in male and increased in female by Ang II infusion when compared with vehicle infusion. Nitrites 24-31 angiotensinogen Rattus norvegicus 89-95 29306125-6 2018 The increased NO3--N/SCN--N ratio in the treated wastewater resulted in the decreased removal efficiency of nitrate, and the increased nitrate-to-nitrite transformation ratio and the ratio of NO2--N to NH4+-N. Nitrites 146-153 NBL1, DAN family BMP antagonist Homo sapiens 14-17 29505609-0 2018 Phosphorylated vasodilator-stimulated phosphoprotein (P-VASPSer239) in platelets is increased by nitrite and partially deoxygenated erythrocytes. Nitrites 97-104 vasodilator stimulated phosphoprotein Homo sapiens 15-52 29505609-3 2018 In this study, we investigated the effect of nitrite on phosphorylation of vasodilator-stimulated phosphoprotein on residue serine 239 (P-VASPSer239), a marker of protein kinase G (PKG) activation, in human platelets. Nitrites 45-52 vasodilator stimulated phosphoprotein Homo sapiens 75-112 29505609-3 2018 In this study, we investigated the effect of nitrite on phosphorylation of vasodilator-stimulated phosphoprotein on residue serine 239 (P-VASPSer239), a marker of protein kinase G (PKG) activation, in human platelets. Nitrites 45-52 protein kinase cGMP-dependent 1 Homo sapiens 163-179 29505609-9 2018 They also further support the idea that partially deoxygenated erythrocytes may modulate platelet activity, at least in part, via the NO/sGC/PKG pathway from NO formed by reduction of circulating nitrite ions. Nitrites 196-203 sarcoglycan beta Homo sapiens 137-140 29505609-9 2018 They also further support the idea that partially deoxygenated erythrocytes may modulate platelet activity, at least in part, via the NO/sGC/PKG pathway from NO formed by reduction of circulating nitrite ions. Nitrites 196-203 protein kinase cGMP-dependent 1 Homo sapiens 141-144 29355738-3 2018 Beyond these CO2 and pH-linked roles, it has been postulated that CA II might also reduce nitrite (NO2-) to nitric oxide (NO), as bicarbonate and NO2- both exhibit sp2 molecular geometry and NO also plays an important role in vasodilation and regulation of blood pressure. Nitrites 90-97 carbonic anhydrase 2 Bos taurus 66-71 29355738-5 2018 have shown that bovine CA II (BCA II) possesses nitrite dehydration activity and paradoxically demonstrated that CA inhibitors (CAIs) such as dorzolamide and acetazolamide significantly increased NO production (Aamand et al., 2009; Nielsen and Fago, 2015) [1,2]. Nitrites 48-55 carbonic anhydrase 2 Bos taurus 23-28 29291791-2 2018 Nitrite is on-line reduced to volatile nitric oxide (NO) by 1.5% (m/v) ascorbic acid and 1.0 mol L-1 hydrochloric acid. Nitrites 0-7 L1 cell adhesion molecule Mus musculus 97-100 29291791-5 2018 The limit of detection of the proposed method was calculated to be 0.26 mug mL-1 of nitrite by measuring NO emission at 237.0 nm. Nitrites 84-91 L1 cell adhesion molecule Mus musculus 76-80 29291791-6 2018 The calibration curve is linear for the nitrite concentration in the range of 2.0-100.0 mug mL-1 and good precision (2.3%, RSD) is readily achieved for 5.0 mug mL-1 nitrite. Nitrites 40-47 L1 cell adhesion molecule Mus musculus 92-96 29291791-6 2018 The calibration curve is linear for the nitrite concentration in the range of 2.0-100.0 mug mL-1 and good precision (2.3%, RSD) is readily achieved for 5.0 mug mL-1 nitrite. Nitrites 40-47 L1 cell adhesion molecule Mus musculus 160-164 29248688-6 2018 Under optimum conditions, the limits of detection in the original solutions were 0.49 mug L-1 and 0.40 mug L-1 for nitrate and nitrite, respectively. Nitrites 127-134 immunoglobulin kappa variable 1-16 Homo sapiens 107-110 29291791-6 2018 The calibration curve is linear for the nitrite concentration in the range of 2.0-100.0 mug mL-1 and good precision (2.3%, RSD) is readily achieved for 5.0 mug mL-1 nitrite. Nitrites 165-172 L1 cell adhesion molecule Mus musculus 92-96 29291791-6 2018 The calibration curve is linear for the nitrite concentration in the range of 2.0-100.0 mug mL-1 and good precision (2.3%, RSD) is readily achieved for 5.0 mug mL-1 nitrite. Nitrites 165-172 L1 cell adhesion molecule Mus musculus 160-164 29495331-1 2018 A novel fluorescence sensor of NR-beta-CD@AuNPs was prepared for the trace detection of nitrite in quantities as low as 4.25 x 10-3 mug mL-1 in an aqueous medium. Nitrites 88-95 L1 cell adhesion molecule Mus musculus 136-140 29531923-9 2018 Results: In female rats, the serum and kidney nitrite levels increased significantly by Ang II (P < 0.05) and decreased significantly (P < 0.05) when PD123319 was accompanied with Ang II. Nitrites 46-53 angiotensinogen Rattus norvegicus 88-94 29531923-9 2018 Results: In female rats, the serum and kidney nitrite levels increased significantly by Ang II (P < 0.05) and decreased significantly (P < 0.05) when PD123319 was accompanied with Ang II. Nitrites 46-53 angiotensinogen Rattus norvegicus 186-192 29414908-2 2018 For myoglobin (Mb), an initial binding of nitrite to the iron-coordinated oxygen molecule was proposed; the resulting ferrous-peroxynitrate species was not detected, but its decay product, the high-valent ferryl form, was demonstrated in stopped-flow experiments. Nitrites 42-49 myoglobin Bos taurus 4-13 29964852-5 2018 The highest concentrations of nitrite for Reactors I, II, III, and IV were 20.83, 22.81, 21.50, and 20.73 mg L-1, respectively, which occurred in the 30th, 35th, 38th, and 42nd cycles, respectively. Nitrites 30-37 immunoglobulin kappa variable 1-16 Homo sapiens 109-112 29355312-11 2018 We present here important mechanistic aspects of the copper-mediated nitrite reduction pathway with the use of model complexes employing the ligand HL2 and an analogous phenyl-based ligand, N-[2-(methylthio)phenyl]-2"-pyridinecarboxamide (HL1). Nitrites 69-76 intelectin 2 Homo sapiens 148-151 29355312-11 2018 We present here important mechanistic aspects of the copper-mediated nitrite reduction pathway with the use of model complexes employing the ligand HL2 and an analogous phenyl-based ligand, N-[2-(methylthio)phenyl]-2"-pyridinecarboxamide (HL1). Nitrites 69-76 intelectin 1 Homo sapiens 239-242 28949404-6 2018 These changes were associated with increased expression and/or activities of Syk, NF-kappaB p65, iNOS and COX-2 and decreased expression of IkappaB-alpha with enhanced levels of nitrite, nitrotyrosine, 6-keto-PGF1alpha , and TNF-alpha and activity of MPO in renal, cardiac and vascular tissues. Nitrites 178-185 NFKB inhibitor alpha Rattus norvegicus 140-153 29253818-8 2018 The infected groups treated with Asp49-PLA2-liposomes showed significant production in TNF-alpha measured in lymph nodes and paw (43.73pg/mL+-2.25 and 81.03pg/mL+-5.52, respectively) and nitrite levels (31.28muM+-0.58 and 35.64muM+-5.08) also measured in lymph nodes and paw tissues, respectively, compared to untreated groups. Nitrites 187-194 phospholipase A2, group V Mus musculus 39-43 29253818-8 2018 The infected groups treated with Asp49-PLA2-liposomes showed significant production in TNF-alpha measured in lymph nodes and paw (43.73pg/mL+-2.25 and 81.03pg/mL+-5.52, respectively) and nitrite levels (31.28muM+-0.58 and 35.64muM+-5.08) also measured in lymph nodes and paw tissues, respectively, compared to untreated groups. Nitrites 187-194 tumor necrosis factor Mus musculus 87-96 29450536-8 2018 Nitrate/nitrite levels in HLE cells showed a significant increase with 2% Cu-Ch treatment compared to CS. Nitrites 8-15 elastase, neutrophil expressed Homo sapiens 26-29 29362099-1 2018 Nitrate reductase (NR) mainly reduces nitrate to nitrite. Nitrites 49-56 nitrate reductase [NADH]-like Cucumis sativus 0-17 29362099-1 2018 Nitrate reductase (NR) mainly reduces nitrate to nitrite. Nitrites 49-56 nitrate reductase [NADH]-like Cucumis sativus 19-21 29362099-12 2018 Moreover, the increase of nitrite tissue level in short-term stressed roots and the nitrite/nitrate ratio, with a simultaneous decrease of nitrite reductase (NiR) activity, in both short- and long-term stressed roots, could promote the production of NO by NR in roots under salt stress. Nitrites 26-33 nitrate reductase [NADH]-like Cucumis sativus 256-258 29362099-12 2018 Moreover, the increase of nitrite tissue level in short-term stressed roots and the nitrite/nitrate ratio, with a simultaneous decrease of nitrite reductase (NiR) activity, in both short- and long-term stressed roots, could promote the production of NO by NR in roots under salt stress. Nitrites 84-91 nitrate reductase [NADH]-like Cucumis sativus 256-258 29257867-1 2018 The fundamental biogeochemical cycle of nitrogen includes cytochrome c nitrite reductase, which catalyzes the reduction of nitrite ions to ammonium with eight protons and six electrons (NO2- + 8H+ + 6e- NH4+ + 2H2O). Nitrites 71-78 cytochrome c, somatic Homo sapiens 58-70 29404208-7 2018 Environmental factors (especially turbidity and nitrite) exhibited significant influences on bacterial beta-diversity in surface water (at 0 m sampling depth), while community similarity in bottom water (at 2-3 m above sediment) was mainly determined by depth. Nitrites 48-55 INTS3 and NABP interacting protein Homo sapiens 79-81 29404208-7 2018 Environmental factors (especially turbidity and nitrite) exhibited significant influences on bacterial beta-diversity in surface water (at 0 m sampling depth), while community similarity in bottom water (at 2-3 m above sediment) was mainly determined by depth. Nitrites 48-55 INTS3 and NABP interacting protein Homo sapiens 118-120 28873645-3 2018 The combined effect of pH (from 7.2 to 3.2) and myoglobin oxidation state was evaluated in the reaction of nitrite with heme iron, and the observed rate constants of the reactions were determined. Nitrites 107-114 myoglobin Homo sapiens 48-57 28886566-6 2018 Removal of 60mgL-1 NH4+-N was associated only with smaller amounts of nitrite build-up (~5mgL-1 NO2--N) and negligible nitrate concentrations. Nitrites 70-77 LLGL scribble cell polarity complex component 1 Homo sapiens 13-18 29070503-8 2018 Additionally, the training-induced change in cfPWV was negatively correlated with the training-induced change in serum adiponectin, CTRP3, and CTRP5 levels ( r = -0.51, r = -0.48, r = -0.42, respectively, P < 0.05), and increased plasma nitrite/nitrate level by exercise training was correlated only with adiponectin levels ( r = 0.41, P < 0.05). Nitrites 240-247 adiponectin, C1Q and collagen domain containing Homo sapiens 119-130 29965686-5 2018 When the concentration of phosphate was 80 mg L-1, with an ammonia conversion rate 13.6%, accumulation rate of nitrite of 18.19%, and nitrite generation rate of 0.54 g (m3 d)-1, the reaction was severely inhibited. Nitrites 134-141 immunoglobulin kappa variable 1-16 Homo sapiens 46-49 29778214-4 2018 Consistent with this characterization, investigations into the biological function of bNOS have also emphasized a role for NOS-dependent nitrate and nitrite production in aerobic and microaerobic respiration. Nitrites 149-156 nitric oxide synthase 1 Homo sapiens 86-90 29643310-6 2018 However, the presence of nitrite at more than 10 muM interfered with the formation of HTP. Nitrites 25-32 latexin Homo sapiens 49-52 29071817-8 2018 CONCLUSIONS: Determining the levels of urinary YKL-40/Cr may help identify true cases of UTI in febrile young children, especially when they have pyuria but not nitrite, or have neither pyuria nor nitrite in the urine. Nitrites 161-168 chitinase 3 like 1 Homo sapiens 47-53 29071817-8 2018 CONCLUSIONS: Determining the levels of urinary YKL-40/Cr may help identify true cases of UTI in febrile young children, especially when they have pyuria but not nitrite, or have neither pyuria nor nitrite in the urine. Nitrites 197-204 chitinase 3 like 1 Homo sapiens 47-53 28816057-5 2018 Nitrite also rescues respiratory reserve capacity and increases proton leakage in LRRK2 PD patients" dermal fibroblasts. Nitrites 0-7 leucine rich repeat kinase 2 Homo sapiens 82-87 30703768-8 2018 RESULTS: PeTP (40%) significantly inhibited the IL-1beta-induced expression of nitrite, iNOS, PGE2, COX-2, MMP-1, MMP-3, MMP-13, and ADAMTS-4 in isolated primary rat chondrocytes. Nitrites 79-86 interleukin 1 beta Rattus norvegicus 48-56 29180007-7 2018 Accordingly, LPS-induced nitrite production was enhanced in primary astrocytes cultured from Fyn-deficient mice or rats. Nitrites 25-32 Fyn proto-oncogene Mus musculus 93-96 29380952-1 2018 Dietary nitrate (NO3-) is converted to nitrite (NO2-) and can be further reduced to the vasodilator nitric oxide (NO) amid a low O2 environment. Nitrites 39-46 NBL1, DAN family BMP antagonist Homo sapiens 17-20 29796576-6 2018 Paired urinalysis and urine culture from group culture-positive and group culture-negative were used to determine the sensitivity and specificity of pyuria and nitrite tests in detecting UTI. Nitrites 160-167 alpha-1-microglobulin/bikunin precursor Homo sapiens 187-190 29796576-16 2018 Positive nitrite is highly suggestive of UTI but has low sensitivity; whereas pyuria >= 10,000/mL revealed good sensitivity, but low specificity. Nitrites 9-16 alpha-1-microglobulin/bikunin precursor Homo sapiens 41-44 29473797-5 2018 Among various antioxidants, Vit E reacted more effectively with many nitrosating agents such as nitrate and nitrite found in cosmetic products. Nitrites 108-115 vitrin Homo sapiens 28-31 29281743-4 2017 Our data show that Hdac6-/- bone marrow-derived dendritic cells (BMDCs) have a higher bacterial load than Hdac6+/+ cells, correlating with weaker induction of IFN-related genes, pro-inflammatory cytokines and nitrite production after bacterial infection. Nitrites 209-216 histone deacetylase 6 Mus musculus 19-24 28917735-0 2018 Trace analysis of nitrite ions in environmental samples by using in-situ synthesized Zein biopolymeric nanoparticles as the novel green solid phase extractor. Nitrites 18-25 zein Zea mays 85-89 28917735-1 2018 For the first time, a novel green method using Zein biopolymeric nanoparticles as a green dispersive solid-phase extractor is reported for the separation and preconcentration of trace amount of nitrite (NO2-) ions in ppb levels. Nitrites 194-201 zein Zea mays 47-51 29321744-7 2017 Computer simulations for NO and O2 transport using reaction parameters reported in the literature were also conducted to predict nitrite-dependent NO production from XOR and AOR activity as a function of nitrite concentration, PO2 and pH. Nitrites 129-136 xanthine dehydrogenase Rattus norvegicus 166-169 29321744-7 2017 Computer simulations for NO and O2 transport using reaction parameters reported in the literature were also conducted to predict nitrite-dependent NO production from XOR and AOR activity as a function of nitrite concentration, PO2 and pH. Nitrites 204-211 xanthine dehydrogenase Rattus norvegicus 166-169 29321744-9 2017 Nitrite-mediated vasodilation with IP nitrite injections was reduced or abolished after inhibiting XOR with allopurinol (p < 0.001). Nitrites 0-7 xanthine dehydrogenase Rattus norvegicus 99-102 29964577-4 2017 When nitrite increased to 265.6 mg L-1, the MAAOB were inhibited obviously, and ammonia nitrogen removal efficiency decreased to about 63.01%. Nitrites 5-12 immunoglobulin kappa variable 1-16 Homo sapiens 35-38 29964577-5 2017 When influent nitrite concentration increased to 305.6 mg L-1, the removal rate of ammonia nitrogen further decreased to 43.93%. Nitrites 14-21 immunoglobulin kappa variable 1-16 Homo sapiens 58-61 28888950-3 2017 AOX is also reported to catalyze the reductive metabolism of nitro-compounds, N-oxides, sulfoxides, isoxazoles, isothiazoles, nitrite and hydroxamic acids. Nitrites 126-133 aldehyde oxidase 1 Homo sapiens 0-3 29629873-8 2017 ELP-VEGF infusion increased total plasma soluble fms-like tyrosine kinase-1 levels but dramatically reduced free plasma soluble fms-like tyrosine kinase-1 and induced urinary excretion of nitrate/nitrite, indicating enhanced renal nitric oxide signaling. Nitrites 196-203 diazepam binding inhibitor-like 5 Rattus norvegicus 0-3 29629873-8 2017 ELP-VEGF infusion increased total plasma soluble fms-like tyrosine kinase-1 levels but dramatically reduced free plasma soluble fms-like tyrosine kinase-1 and induced urinary excretion of nitrate/nitrite, indicating enhanced renal nitric oxide signaling. Nitrites 196-203 vascular endothelial growth factor A Rattus norvegicus 4-8 28801236-4 2017 METHODS: Biomarkers involved in indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I enzymatic pathways (namely neopterin, tryptophan, kynurenine, phenylalanine, tyrosine, and nitrite) were analyzed in a population of Spanish older adults aged 65 years and above, and their relationships with frailty status were evaluated. Nitrites 197-204 indoleamine 2,3-dioxygenase 1 Homo sapiens 32-61 29063286-10 2017 Immunoblotting revealed that nitrite significantly increased the phosphorylation of Akt (P < 0.05) and reduced the nuclear translocation of NF-kappaB (P < 0.05) compared with the NS group. Nitrites 29-36 AKT serine/threonine kinase 1 Rattus norvegicus 84-87 29053273-4 2017 In this study, we probed Fe(III) heme-nitrite coordination in Alcaligenes xylosoxidans cytochrome c" (AXCP), an NO carrier that excludes anions in its native state but that readily binds nitrite (Kd ~ 0.5 mM) following a distal Leu16 Gly mutation to remove distal steric constraints. Nitrites 38-45 D-alanyl-D-alanine carboxypeptidase Achromobacter xylosoxidans 87-99 28165641-1 2017 Nitrate (NO3-) supplementation resulting in higher plasma nitrite (NO2-) is reported to lower resting mean arterial blood pressure (MAP) and oxygen uptake (VO2 ) during submaximal exercise in non-athletic populations, whereas effects in general are absent in endurance-trained individuals. Nitrites 58-65 NBL1, DAN family BMP antagonist Homo sapiens 9-12 29035054-0 2017 Quantum Yields of Nitrite (NO2-) from the Photolysis of Nitrate (NO3-) in Ice at 313 nm. Nitrites 18-25 NBL1, DAN family BMP antagonist Homo sapiens 65-68 29965410-3 2017 The influent concentration of ammonia and nitrite was 61.44 mg L-1 and 0.77 mg L-1, respectively. Nitrites 42-49 immunoglobulin kappa variable 1-16 Homo sapiens 63-66 29965410-3 2017 The influent concentration of ammonia and nitrite was 61.44 mg L-1 and 0.77 mg L-1, respectively. Nitrites 42-49 immunoglobulin kappa variable 1-16 Homo sapiens 79-82 29965410-5 2017 The nitrite concentrations were 20.57 mg L-1 and 20.18 mg L-1, and the nitrite accumulation rate reached 95.92% and 99.58%, respectively. Nitrites 4-11 immunoglobulin kappa variable 1-16 Homo sapiens 41-51 29965410-5 2017 The nitrite concentrations were 20.57 mg L-1 and 20.18 mg L-1, and the nitrite accumulation rate reached 95.92% and 99.58%, respectively. Nitrites 4-11 immunoglobulin kappa variable 1-16 Homo sapiens 41-44 29053273-4 2017 In this study, we probed Fe(III) heme-nitrite coordination in Alcaligenes xylosoxidans cytochrome c" (AXCP), an NO carrier that excludes anions in its native state but that readily binds nitrite (Kd ~ 0.5 mM) following a distal Leu16 Gly mutation to remove distal steric constraints. Nitrites 187-194 D-alanyl-D-alanine carboxypeptidase Achromobacter xylosoxidans 87-99 28917840-4 2017 Surprisingly, non-cytotoxic NO (S-nitrosoglutathione) and nitrite markedly reduced Hcy-induced IRE1alpha phosphorylation, Xbp1 mRNA splicing, CHOP expression, and Annexin V-positive cells, indicating the cytoprotection of NO and nitrite against Hcy-induced ER stress and apoptosis. Nitrites 58-65 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 95-104 28917840-4 2017 Surprisingly, non-cytotoxic NO (S-nitrosoglutathione) and nitrite markedly reduced Hcy-induced IRE1alpha phosphorylation, Xbp1 mRNA splicing, CHOP expression, and Annexin V-positive cells, indicating the cytoprotection of NO and nitrite against Hcy-induced ER stress and apoptosis. Nitrites 58-65 X-box binding protein 1 Mus musculus 122-126 28917840-4 2017 Surprisingly, non-cytotoxic NO (S-nitrosoglutathione) and nitrite markedly reduced Hcy-induced IRE1alpha phosphorylation, Xbp1 mRNA splicing, CHOP expression, and Annexin V-positive cells, indicating the cytoprotection of NO and nitrite against Hcy-induced ER stress and apoptosis. Nitrites 58-65 DNA-damage inducible transcript 3 Mus musculus 142-146 28917840-4 2017 Surprisingly, non-cytotoxic NO (S-nitrosoglutathione) and nitrite markedly reduced Hcy-induced IRE1alpha phosphorylation, Xbp1 mRNA splicing, CHOP expression, and Annexin V-positive cells, indicating the cytoprotection of NO and nitrite against Hcy-induced ER stress and apoptosis. Nitrites 58-65 annexin A5 Mus musculus 163-172 28917840-5 2017 Moreover, inhibition of sGC/cGMP pathway abolished the cytoprotective effects of NO and nitrite, whereas cellular elevation of cGMP levels mimicked the cytoprotective actions of NO and nitrite. Nitrites 88-95 serglycin Mus musculus 24-27 28917840-6 2017 These findings provide the first evidence showing that both NO and nitrite can reduce ER stress and subsequent apoptosis via NO-sGC-cGMP pathway in neuronal cells and suggesting that NO and/or nitrite may have therapeutic value in the treatment of ER stress-associated neurodegenerative diseases. Nitrites 67-74 serglycin Mus musculus 128-131 28917840-6 2017 These findings provide the first evidence showing that both NO and nitrite can reduce ER stress and subsequent apoptosis via NO-sGC-cGMP pathway in neuronal cells and suggesting that NO and/or nitrite may have therapeutic value in the treatment of ER stress-associated neurodegenerative diseases. Nitrites 193-200 serglycin Mus musculus 128-131 28948330-0 2017 Spatial and temporal distribution of nitrite-dependent anaerobic methane-oxidizing bacteria in an intertidal zone of the East China Sea. Nitrites 37-44 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 132-135 28968930-4 2017 CCl4 toxicity displayed significant (p<0.05) increase in level of TBARS, H2O2, nitrite while a decrease in SOD, CAT, POD and GSH in liver samples of CCl4 treated group. Nitrites 82-89 C-C motif chemokine ligand 4 Rattus norvegicus 0-4 28833300-9 2017 The limits of detection achieved with this system were 2.8 muM for nitrite and 5.7 muM for ascorbate. Nitrites 67-74 latexin Homo sapiens 59-62 29145236-7 2017 Western blot analyses showed that nitrite pretreatment resulted in up-regulation of antiapoptotic factors Bcl-2 and p21waf1/cip1 signal proteins, but down-regulation of the proapoptotic factor Bax signal protein. Nitrites 34-41 B cell leukemia/lymphoma 2 Mus musculus 106-111 29145236-7 2017 Western blot analyses showed that nitrite pretreatment resulted in up-regulation of antiapoptotic factors Bcl-2 and p21waf1/cip1 signal proteins, but down-regulation of the proapoptotic factor Bax signal protein. Nitrites 34-41 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 124-128 29145236-7 2017 Western blot analyses showed that nitrite pretreatment resulted in up-regulation of antiapoptotic factors Bcl-2 and p21waf1/cip1 signal proteins, but down-regulation of the proapoptotic factor Bax signal protein. Nitrites 34-41 BCL2-associated X protein Mus musculus 193-196 29145236-8 2017 Furthermore, nitrite pretreatment also showed significant alleviation of AMI-induced signal protein expressions of inflammatory factors of NF-K B and oxidative factors of Hsp 70 and HO-1. Nitrites 13-20 heme oxygenase 1 Mus musculus 182-186 29145236-9 2017 CONCLUSION: These results suggest that nitrite show certain protective effects against the ischemic effects induced by AMI in mice, which might be attributed to the synthesis of NO induced by iNOS through up-regulation of antiapoptotic factors and down-regulation of proapoptotic and inflammatory factors. Nitrites 39-46 nitric oxide synthase 2, inducible Mus musculus 192-196 28941934-8 2017 Plasma nitrite concentrations significantly increased in nitrate supplementation compared to Placebo and Baseline (502 +- 246 nmol L-1; 73 +- 45 nmol L-1; 74 +- 49 nmol L-1 respectively; n = 11; P < 0.001). Nitrites 7-14 immunoglobulin kappa variable 1-16 Homo sapiens 150-153 28941934-8 2017 Plasma nitrite concentrations significantly increased in nitrate supplementation compared to Placebo and Baseline (502 +- 246 nmol L-1; 73 +- 45 nmol L-1; 74 +- 49 nmol L-1 respectively; n = 11; P < 0.001). Nitrites 7-14 immunoglobulin kappa variable 1-16 Homo sapiens 150-153 28804234-15 2017 Significant positive correlation was observed between nitrite and CRP ( r = 0.46, p < 0.05), TNF-alpha ( r = 0.53, p < 0.05), and inverse correlation with FMD ( r =0.62, p < 0.05). Nitrites 54-61 C-reactive protein Homo sapiens 66-69 28067100-10 2017 In turn, the pre- and post-exercise plasma concentrations of nitrite (NO2-) and nitrate (NO3-) were decreased in ApoE/LDLR-/- as compared to that in age-matched WT mice. Nitrites 61-68 apolipoprotein E Mus musculus 113-117 28067100-10 2017 In turn, the pre- and post-exercise plasma concentrations of nitrite (NO2-) and nitrate (NO3-) were decreased in ApoE/LDLR-/- as compared to that in age-matched WT mice. Nitrites 61-68 low density lipoprotein receptor Mus musculus 118-122 28622138-11 2017 The significant decrease in nitrite levels in myeloid leukemia suggests a decrease in nitric oxide synthase (NOS) activity. Nitrites 28-35 nitric oxide synthase 2 Homo sapiens 86-107 28957386-7 2017 In addition, these three warm years continued the pattern near St. Matthew Island of high concentrations (>1 muM) of nitrite occurring during summer in warm years. Nitrites 120-127 latexin Homo sapiens 112-115 28869560-4 2017 Moreover, these new PDE10A inhibitors were able to decrease the nitrite production in LPS-stimulated cells, thus demonstrating their potential as anti-inflammatory agents. Nitrites 64-71 phosphodiesterase 10A Homo sapiens 20-26 28590566-3 2017 Among the NO donors, tetraazamacrocyclic nitrosyl complexes, such as trans-[Ru(NO)Cl(cyclam)](PF6 )2 (cyclamNO), gained attention for their features, which include the possibility of being embedded in solid matrices, and ability to participate in a nitrite/NO catalytic conversion cycle. Nitrites 249-256 sperm associated antigen 17 Homo sapiens 94-97 29729279-3 2018 Renal CAII and CAIV are involved in the reabsorption of nitrite, the autoxidation product of the signalling molecule nitric oxide (NO): 4 NO + O2 + 2 H2O 4 ONO- + 4 H+. Nitrites 56-63 carbonic anhydrase 2 Homo sapiens 6-10 29729279-3 2018 Renal CAII and CAIV are involved in the reabsorption of nitrite, the autoxidation product of the signalling molecule nitric oxide (NO): 4 NO + O2 + 2 H2O 4 ONO- + 4 H+. Nitrites 56-63 carbonic anhydrase 4 Homo sapiens 15-19 28710281-1 2017 Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure. Nitrites 19-26 NBL1, DAN family BMP antagonist Mus musculus 106-109 28671819-3 2017 Cytoglobin is involved in cytoprotection pathways through yet undefined mechanisms, and it has recently been demonstrated that cytoglobin has redox signaling properties via nitric oxide (NO) and nitrite metabolism. Nitrites 195-202 cytoglobin Homo sapiens 127-137 28463648-9 2017 After M. tuberculosis infection, TOLLIP-deficient monocytes demonstrated increased IL-6, increased nitrite, and decreased bacterial replication. Nitrites 99-106 toll interacting protein Homo sapiens 33-39 28778164-21 2017 Serum level of total protein, albumin, globulin, nitrite, creatinine and blood urea nitrogen (BUN) was significantly increased (P < 0.01) by CCl4 treatment. Nitrites 49-56 C-C motif chemokine ligand 4 Rattus norvegicus 144-148 28671819-5 2017 When deoxygenated, cytoglobin can bind nitrite and reduce it to NO. Nitrites 39-46 cytoglobin Homo sapiens 19-29 28942826-17 2017 Nitrite level was unchanged by l-NAME but increased after 7-NI which also resulted in decreased GSH concentration and PON1 activity. Nitrites 0-7 paraoxonase 1 Rattus norvegicus 118-122 28660510-0 2017 Taurine mitigates nitrite-induced methemoglobin formation and oxidative damage in human erythrocytes. Nitrites 18-25 hemoglobin subunit gamma 2 Homo sapiens 34-47 28534128-9 2017 Serum cathepsin L activity positively associated with age, body mass index, nitrite level, neutrophil count, high-sensitivity C-reactive protein (hs-CRP), N-terminal pro-brain natriuretic peptide, high-mobility group box-1 protein (HMGB1) and 24-h proteinuria. Nitrites 76-83 cathepsin L Homo sapiens 6-17 28285190-0 2017 Nitrate decreases xanthine oxidoreductase-mediated nitrite reductase activity and attenuates vascular and blood pressure responses to nitrite. Nitrites 51-58 xanthine dehydrogenase Rattus norvegicus 18-41 28285190-3 2017 Moreover, xanthine oxidoreductase (XOR) mediates NO formation from nitrite and nitrate. Nitrites 67-74 xanthine dehydrogenase Rattus norvegicus 10-33 28285190-3 2017 Moreover, xanthine oxidoreductase (XOR) mediates NO formation from nitrite and nitrate. Nitrites 67-74 xanthine dehydrogenase Rattus norvegicus 35-38 28285190-4 2017 However, no study has examined whether nitrate attenuates XOR-mediated NO generation from nitrite. Nitrites 90-97 xanthine dehydrogenase Rattus norvegicus 58-61 28285190-5 2017 We hypothesized that nitrate attenuates the vascular and blood pressure responses to nitrite either by interfering with nitrite influx into vascular tissue, or by competing with nitrite for XOR, thus inhibiting XOR-mediated NO generation. Nitrites 85-92 xanthine dehydrogenase Rattus norvegicus 211-214 28285190-14 2017 Together, our results show that nitrate inhibits XOR-mediated NO production from nitrite, and this mechanism may explain how nitrate attenuates the vascular and blood pressure responses to nitrite. Nitrites 81-88 xanthine dehydrogenase Rattus norvegicus 49-52 28285190-14 2017 Together, our results show that nitrate inhibits XOR-mediated NO production from nitrite, and this mechanism may explain how nitrate attenuates the vascular and blood pressure responses to nitrite. Nitrites 189-196 xanthine dehydrogenase Rattus norvegicus 49-52 28824623-3 2017 In this regard, we identified in murine Hepa1-6 hepatoma cells a potent synergism between pro-inflammatory interleukin-beta/tumor necrosis factor-alpha and immunoregulatory IFNbeta as detected by analysis of iNOS expression and nitrite release. Nitrites 228-235 interferon beta 1, fibroblast Mus musculus 173-180 28683730-6 2017 RESULTS: The presence of leukocyte esterase and nitrites on urinalysis was associated with increased urinary NGAL (R2 0.16, p < 0.001 and R2 0.07, p < 0.001, respectively) in pre-operative samples. Nitrites 48-56 lipocalin 2 Homo sapiens 109-113 28573318-8 2017 Under the optimized experimental conditions, the signal intensity was linear over a nitrite concentration range of 0.006-0.075 mg L-1, with a correlation coefficient better than 0.9994. Nitrites 84-91 immunoglobulin kappa variable 1-16 Homo sapiens 130-133 28573318-9 2017 The limit of detection was 2.1 mug L-1 for the determination of nitrite by the proposed method. Nitrites 64-71 immunoglobulin kappa variable 1-16 Homo sapiens 35-38 28488787-2 2017 Here, we exposed replicate flow-through biofilm systems, fed with nitrite-supplemented tap water, to continuous immigration from a source community, present in the tap water, to determine the extent of selection and neutral processes in newly assembled biofilm communities at both the community and the functional guild (of nitrite-oxidizing bacteria, NOB) levels. Nitrites 66-73 nuclear RNA export factor 1 Homo sapiens 87-90 28656558-8 2017 Organic carbon increased the sensor nitrate plus nitrite results, not only in waters with high organic carbon concentrations, but also at the lower concentrations (< 10 mg C L-1) typical of boreal stream, river, and lake waters. Nitrites 49-56 adhesion G protein-coupled receptor L1 Homo sapiens 175-180 28343245-3 2017 The detection limit of nitrite ions was determined to be 9.4 nM (S/N = 3) and the linear range with high linear correlation was observed between 0.025 to 2.5 muM. Nitrites 23-30 latexin Homo sapiens 158-161 28458145-0 2017 Chlorite reactivity with myoglobin: Analogy with peroxide and nitrite chemistry? Nitrites 62-69 myoglobin Homo sapiens 25-34 28363495-2 2017 Production of NO through the reduction of endogenous myocardial nitrite by deoxygenated myoglobin has been shown to significantly reduce myocardial infarction damage and ischemic injury. Nitrites 64-71 myoglobin Homo sapiens 88-97 28392447-13 2017 Nitrite, in turn, prevented an I/R induced increase of calpains 10 at mitochondria and reduced levels of calpain 1. Nitrites 0-7 calpain 1 Homo sapiens 105-114 28438687-7 2017 However, dietary nitrite supplementation inhibited TGF-beta1-mediated cardiac remodeling by suppressing AT II and AT1R. Nitrites 17-24 transforming growth factor, beta 1 Rattus norvegicus 51-60 28438687-7 2017 However, dietary nitrite supplementation inhibited TGF-beta1-mediated cardiac remodeling by suppressing AT II and AT1R. Nitrites 17-24 angiotensinogen Rattus norvegicus 104-109 28438687-7 2017 However, dietary nitrite supplementation inhibited TGF-beta1-mediated cardiac remodeling by suppressing AT II and AT1R. Nitrites 17-24 angiotensin II receptor, type 1a Rattus norvegicus 114-118 28438687-8 2017 These results suggest that dietary nitrite levels achievable via a daily high-vegetable diet could improve hypertensive heart disease by inhibiting AT II-AT1R-mediated cardiac remodeling. Nitrites 35-42 angiotensinogen Rattus norvegicus 148-153 28438687-8 2017 These results suggest that dietary nitrite levels achievable via a daily high-vegetable diet could improve hypertensive heart disease by inhibiting AT II-AT1R-mediated cardiac remodeling. Nitrites 35-42 angiotensin II receptor, type 1a Rattus norvegicus 154-158 27987212-9 2017 Hence the ETC, likely the Q-cycle of Complex III generates NO from nitrite, and AOX reduces this activity by acting as a non-energy-conserving electron sink upstream of Complex III. Nitrites 67-74 ubiquinol oxidase 1, mitochondrial Nicotiana tabacum 80-83 28333392-4 2017 We report that C. reinhardtii supplied with nitrite (NO2- ) under aerobic conditions can reduce NO2- into nitric oxide (NO) using either a mitochondrial cytochrome c oxidase (COX) or a dual enzymatic system of nitrate reductase (NR) and amidoxime-reducing component, and that NO is subsequently reduced into N2 O by the enzyme NO reductase (NOR). Nitrites 44-51 uncharacterized protein Chlamydomonas reinhardtii 210-227 28333392-4 2017 We report that C. reinhardtii supplied with nitrite (NO2- ) under aerobic conditions can reduce NO2- into nitric oxide (NO) using either a mitochondrial cytochrome c oxidase (COX) or a dual enzymatic system of nitrate reductase (NR) and amidoxime-reducing component, and that NO is subsequently reduced into N2 O by the enzyme NO reductase (NOR). Nitrites 44-51 uncharacterized protein Chlamydomonas reinhardtii 229-231 28680423-8 2017 Use of bioreactors to study the effect of nitrate injection on sulfate reduction showed that accumulation of nitrite inhibited SRB activity at 2.5 M but not at 0.5 M NaCl. Nitrites 109-116 chaperonin containing TCP1 subunit 4 Homo sapiens 127-130 28617311-1 2017 This study aimed to investigate whether the -1026(A>C)(rs2779249) and +2087(A>G)(2297518) polymorphisms in the NOS2 gene were associated with chronic periodontitis (CP) and with salivary levels of nitrite (NO2-) and/or nitrate + nitrite (NOx). Nitrites 203-210 nitric oxide synthase 2 Homo sapiens 117-121 28617311-1 2017 This study aimed to investigate whether the -1026(A>C)(rs2779249) and +2087(A>G)(2297518) polymorphisms in the NOS2 gene were associated with chronic periodontitis (CP) and with salivary levels of nitrite (NO2-) and/or nitrate + nitrite (NOx). Nitrites 235-242 nitric oxide synthase 2 Homo sapiens 117-121 28843240-3 2017 The research proposed that organic nitrites, nitro oxide, cyanides, and isocyanides of cigarette smoke interfere with vitamin B12 metabolism, and convert it to inactive forms. Nitrites 35-43 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 126-129 28422664-7 2017 Experimental results show a better detection of nitrite, a surrogate of UTI, than that of conventional dipstick testing. Nitrites 48-55 alpha-1-microglobulin/bikunin precursor Homo sapiens 72-75 28289922-10 2017 Significant inhibition in mRNA expression of iNOS, TGF-beta1 and TNF-alpha level was noted after curcumin treatment along with lowered MPO activity, inflammatory cell count, ROS, nitrite levels and collagen deposition in lungs. Nitrites 179-186 nitric oxide synthase 2, inducible Mus musculus 45-49 28521187-11 2017 Nitrite levels were increased in CORT-treated animals and reversed by MIRT+ALA200 (HC), MIRT or MIRT+ALA (ST). Nitrites 0-7 cortistatin Homo sapiens 33-37 28542575-5 2017 In addition, melatonin increased dityrosine levels but suppressed nitrite levels by upregulating the expression of Nrf2 and heme oxygenase-1 in the Nrf2 antioxidant defense pathway. Nitrites 66-73 NFE2 like bZIP transcription factor 2 Bos taurus 115-119 28282582-4 2017 In this work the effect of nitrite on the catalytic reactions of catalase was studied. Nitrites 27-34 catalase Homo sapiens 65-73 28282582-5 2017 Catalase was inhibited by nitrite, and this process was pH-dependent. Nitrites 26-33 catalase Homo sapiens 0-8 28282582-7 2017 The presence of chloride significantly enhanced nitrite-induced catalase inhibition, in agreement with earlier observations. Nitrites 48-55 catalase Homo sapiens 64-72 28282582-8 2017 The kinetics of the reactions of nitrite with ferric catalase, its redox intermediate, Compound I, and catalase inactive form, Compound II, was also studied. Nitrites 33-40 catalase Homo sapiens 53-61 28282582-8 2017 The kinetics of the reactions of nitrite with ferric catalase, its redox intermediate, Compound I, and catalase inactive form, Compound II, was also studied. Nitrites 33-40 catalase Homo sapiens 103-111 28282582-9 2017 Possible mechanisms of nitrite-induced catalase inhibition are analyzed and the biological consequences of the reactions of catalase with nitrite are discussed. Nitrites 23-30 catalase Homo sapiens 39-47 28282582-9 2017 Possible mechanisms of nitrite-induced catalase inhibition are analyzed and the biological consequences of the reactions of catalase with nitrite are discussed. Nitrites 23-30 catalase Homo sapiens 124-132 28282582-9 2017 Possible mechanisms of nitrite-induced catalase inhibition are analyzed and the biological consequences of the reactions of catalase with nitrite are discussed. Nitrites 138-145 catalase Homo sapiens 124-132 28415421-5 2017 The linear ranges of nitrite are 0.5-366.4muM and 466.4-2666.4muM for the two segments, and the detection limit is 0.03muM (S/N=3). Nitrites 21-28 latexin Homo sapiens 42-45 28282582-0 2017 Interactions of nitrite with catalase: Enzyme activity and reaction kinetics studies. Nitrites 16-23 catalase Homo sapiens 29-37 28224182-13 2017 Moreover, PARP inhibition alleviated the elevated serum TNF-alpha level, renal NFkappaB, nitrite, and the decrease in SOD activity in diabetic animals. Nitrites 89-96 poly (ADP-ribose) polymerase 1 Rattus norvegicus 10-14 28542575-5 2017 In addition, melatonin increased dityrosine levels but suppressed nitrite levels by upregulating the expression of Nrf2 and heme oxygenase-1 in the Nrf2 antioxidant defense pathway. Nitrites 66-73 heme oxygenase 1 Bos taurus 124-140 28542575-5 2017 In addition, melatonin increased dityrosine levels but suppressed nitrite levels by upregulating the expression of Nrf2 and heme oxygenase-1 in the Nrf2 antioxidant defense pathway. Nitrites 66-73 NFE2 like bZIP transcription factor 2 Bos taurus 148-152 31057865-8 2017 The sensor demonstrated a sensitivity of 0.21 muA muM-1 cm-2 in the range of 20-100 muM and of 0.1 muA muM-1 cm-2 in the range of 100-1000 muM nitrite concentration and exhibited a low detection limit of 830 nM in the EBC matrix. Nitrites 143-150 PWWP domain containing 3A, DNA repair factor Homo sapiens 50-55 31057865-8 2017 The sensor demonstrated a sensitivity of 0.21 muA muM-1 cm-2 in the range of 20-100 muM and of 0.1 muA muM-1 cm-2 in the range of 100-1000 muM nitrite concentration and exhibited a low detection limit of 830 nM in the EBC matrix. Nitrites 143-150 latexin Homo sapiens 50-53 31057865-8 2017 The sensor demonstrated a sensitivity of 0.21 muA muM-1 cm-2 in the range of 20-100 muM and of 0.1 muA muM-1 cm-2 in the range of 100-1000 muM nitrite concentration and exhibited a low detection limit of 830 nM in the EBC matrix. Nitrites 143-150 PWWP domain containing 3A, DNA repair factor Homo sapiens 103-108 28187386-2 2017 High nitrite (NO2--N) was produced from NO3--N reduction in partial-denitrification process, which served as electron acceptor for anammox and was removed with ammonia (NH4+-N) in domestic wastewater simultaneously. Nitrites 5-12 NBL1, DAN family BMP antagonist Homo sapiens 40-43 28505174-8 2017 RESULTS: On average nitrite-modified ECM increased VEGF release both apically and basally by 0.15 +- 0.014 ng/mL (p <0.0001) and 0.21 +- 0.022 ng/mL (p <0.0001), respectively, in iPSC-derived RPE cells. Nitrites 20-27 vascular endothelial growth factor A Homo sapiens 51-55 28505174-9 2017 Nitrite-modified ECM increased PEDF release in iPSC-derived RPE cells apically by 0.16 +- 0.031 ng/mL (p <0.0001), but not basally (0.27 +- 0.015 vs. 0.32 +- 0.029 ng/mL, (p >0.05)). Nitrites 0-7 serpin family F member 1 Homo sapiens 31-35 28505174-10 2017 Nitrite-modified ECM increased production of C3a in iPSC-derived RPE cells by 0.52 +- 0.123 ng/mL (p <0.05). Nitrites 0-7 complement C3 Homo sapiens 45-48 28505174-11 2017 CONCLUSION: Nitrite-modified ECM increased VEGF, PEDF release, and C3a production in human iPSC-derived RPE cells. Nitrites 12-19 vascular endothelial growth factor A Homo sapiens 43-47 28505174-11 2017 CONCLUSION: Nitrite-modified ECM increased VEGF, PEDF release, and C3a production in human iPSC-derived RPE cells. Nitrites 12-19 serpin family F member 1 Homo sapiens 49-53 28505174-11 2017 CONCLUSION: Nitrite-modified ECM increased VEGF, PEDF release, and C3a production in human iPSC-derived RPE cells. Nitrites 12-19 complement C3 Homo sapiens 67-70 28259097-10 2017 The increased hippocampal nitrite concentrations caused by ovariectomy were also reversed by EE2 administration. Nitrites 26-33 esterase 3 Mus musculus 93-96 28131792-10 2017 Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue. Nitrites 215-222 interleukin 1 beta Homo sapiens 12-16 28131792-10 2017 Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue. Nitrites 215-222 interleukin 1 receptor antagonist Homo sapiens 86-110 28131792-10 2017 Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue. Nitrites 215-222 interleukin 1 receptor antagonist Homo sapiens 112-118 28383668-3 2017 It can be generated from nitrite through a reductive pathway, notably via the action of the nitrate reductase (NR), and evidence suggests an additional oxidative pathway, involving arginine. Nitrites 25-32 nitrate reductase 1 Arabidopsis thaliana 92-109 28235888-5 2017 Mutations in the SSU1 promoter that selectively inhibit induction by the reactive nitrogen species (RNS) nitrite, a previously reported activator of SSU1, support a model for C. albicans in which Cta4-dependent RNS induction and Zcf2-dependent RSS induction are mediated by parallel pathways, different from S. cerevisiae in which the transcription factor Fzf1 mediates responses to both RNS and RSS. Nitrites 105-112 Fzf1p Saccharomyces cerevisiae S288C 356-360 28340298-1 2017 Photolysis of nitrate (NO3-) produces reactive nitrogen and oxygen species via three different channels, forming: (1) nitrogen dioxide (NO2) and hydroxyl radical ( OH), (2) nitrite (NO2-) and oxygen atom (O(3P)), and (3) peroxynitrite (ONOO-). Nitrites 173-180 NBL1, DAN family BMP antagonist Homo sapiens 23-26 27992114-13 2017 CONCLUSIONS: The increase in total nitrite/nitrotyrosine in DM promoted significant compensatory increases in antioxidant activities of SOD, catalase and glutathione peroxidase/reductase probably to prevent cardiac oxidative damage. Nitrites 35-42 catalase Rattus norvegicus 141-149 28138957-12 2017 This effect is mainly mediated through an enhanced production of NO, cGMP and nitrite, via the induction of iNOS and inhibition of calcium influx through Ca2+ channels in rat aortic smooth muscle. Nitrites 78-85 nitric oxide synthase 2 Rattus norvegicus 108-112 28383668-3 2017 It can be generated from nitrite through a reductive pathway, notably via the action of the nitrate reductase (NR), and evidence suggests an additional oxidative pathway, involving arginine. Nitrites 25-32 nitrate reductase 1 Arabidopsis thaliana 111-113 28089828-13 2017 Nitrite decreased elevated serum IL-1beta in diabetic rats (4.0 +- 0.2 vs. 2.9 +- 0.2 pg/mL, P = 0.001). Nitrites 0-7 interleukin 1 beta Rattus norvegicus 33-41 28089828-14 2017 In diabetic rats, nitrite also significantly increased tissue levels of GLUT4 by 22% and 26% in soleus muscle and epididymal adipose tissue, respectively. Nitrites 18-25 solute carrier family 2 member 4 Rattus norvegicus 72-77 28079226-2 2017 Computational simulation shows that RDX hydrolysis is a highly exothermic multistep process involving initial deprotonation and nitrite elimination, cycle cleavage, further transformation of cycle-opened intermediates to end products caused by a series of C-N bond ruptures, hydroxide attachments, and proton transfers. Nitrites 128-135 radixin Homo sapiens 36-39 28153714-2 2017 A significant source of NO is dietary nitrate (NO3), which is initially metabolized by oral bacteria into nitrite (NO2-) and is subsequently converted into NO once digested in the acidic gastric environment. Nitrites 106-113 NBL1, DAN family BMP antagonist Homo sapiens 47-50 28079226-3 2017 Computationally predicted products of RDX hydrolysis such as nitrite, nitrous oxide, formaldehyde, formate, and ammonia correspond to experimentally observed ones. Nitrites 61-68 radixin Homo sapiens 38-41 28017872-0 2017 Nitrite-derived nitric oxide reduces hypoxia-inducible factor 1alpha-mediated extracellular vesicle production by endothelial cells. Nitrites 0-7 hypoxia inducible factor 1 subunit alpha Homo sapiens 37-68 28325291-5 2017 Nanoparticles harboring iNOS plasmids (constitutively active cytomegalovirus [CMV]-driven or transcriptionally regulated human osteocalcin [hOC]-driven) evoked iNOS protein expression and nitrite accumulation and impaired clonogenicity in the highly aggressive MDA-MB-231 human breast cancer model. Nitrites 188-195 nitric oxide synthase 2 Homo sapiens 24-28 28325291-5 2017 Nanoparticles harboring iNOS plasmids (constitutively active cytomegalovirus [CMV]-driven or transcriptionally regulated human osteocalcin [hOC]-driven) evoked iNOS protein expression and nitrite accumulation and impaired clonogenicity in the highly aggressive MDA-MB-231 human breast cancer model. Nitrites 188-195 bone gamma-carboxyglutamate protein Homo sapiens 127-138 28325291-7 2017 Nanoparticulate RALA/CMV-iNOS or RALA/hOC-iNOS increased median survival in mice bearing micrometastases by 27% compared with controls and also provoked elevated blood nitrite levels. Nitrites 168-175 v-ral simian leukemia viral oncogene A (ras related) Mus musculus 16-20 28325291-7 2017 Nanoparticulate RALA/CMV-iNOS or RALA/hOC-iNOS increased median survival in mice bearing micrometastases by 27% compared with controls and also provoked elevated blood nitrite levels. Nitrites 168-175 nitric oxide synthase 2 Homo sapiens 25-29 28325291-7 2017 Nanoparticulate RALA/CMV-iNOS or RALA/hOC-iNOS increased median survival in mice bearing micrometastases by 27% compared with controls and also provoked elevated blood nitrite levels. Nitrites 168-175 v-ral simian leukemia viral oncogene A (ras related) Mus musculus 33-37 28325291-7 2017 Nanoparticulate RALA/CMV-iNOS or RALA/hOC-iNOS increased median survival in mice bearing micrometastases by 27% compared with controls and also provoked elevated blood nitrite levels. Nitrites 168-175 nitric oxide synthase 2 Homo sapiens 42-46 27075937-0 2017 Nitrite and nitroso compounds can serve as specific catalase inhibitors. Nitrites 0-7 catalase Homo sapiens 52-60 27075937-1 2017 OBJECTIVE: We present evidence that nitrite and nitrosothiols, nitrosoamines and non-heme dinitrosyl iron complexes can reversibly inhibit catalase with equal effectiveness. Nitrites 36-43 catalase Homo sapiens 139-147 27075937-4 2017 It was found that chloride and bromide in concentration above 80 mM and thiocyanate in concentration above 20 muM enhance catalase inhibition by nitrite and the nitroso compounds more than 100 times. Nitrites 145-152 catalase Homo sapiens 122-130 27075937-9 2017 It is probable that a comparatively low chloride concentration in many cells is the main factor to protect catalase from inhibition by nitrite and nitroso compounds. Nitrites 135-142 catalase Homo sapiens 107-115 28107832-7 2017 The 2D device was applied in artificial urine samples and reached limits of detection (LODs) of 0.54 mM, 5.19 muM, and 2.34 muM for glucose, protein, and nitrite, respectively. Nitrites 154-161 latexin Homo sapiens 124-127 28052870-10 2017 During chronic Ang II infusion, urinary nitrite excretion, a marker for renal NO generation, was increased in WT mice, whereas renal cGMP generation was decreased and restored after sildenafil treatment, suggesting a preserved cGMP signaling after PDE5 inhibition. Nitrites 40-47 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 15-21 27874191-6 2017 Limit of detection values were 6.7 and 4.3 muM for nitrate and nitrite, respectively. Nitrites 63-70 latexin Homo sapiens 43-46 27923568-9 2017 The soluble CX3CL1 produced by neurons after noradrenaline treatment, reduced the accumulation of nitrites in microglia. Nitrites 98-106 C-X3-C motif chemokine ligand 1 Homo sapiens 12-18 27894754-5 2017 Furthermore, the applicability of the proposed modified electrode was demonstrated by measuring the concentration of nitrite and nitrate ions in the tap and mineral waters, sausages, salami, and cheese samples. Nitrites 117-124 nuclear RNA export factor 1 Homo sapiens 149-152 27693018-6 2017 Protection was associated with an IFN-gamma production against parasite antigens, which was mediated by both CD4+ and CD8+ T cells and correlated with antileishmanial nitrite production. Nitrites 167-174 interferon gamma Mus musculus 34-43 27821334-1 2017 In this paper, the spherical Au nanoparticles and 3D flower-like structure graphene were successively deposited on glassy carbon electrode (GCE) (Au/f-GE/GCE) via a facile and two-step electrodeposition method for the detection of nitrite ions (NaNO2). Nitrites 231-238 sulfatase modifying factor 1 Homo sapiens 149-153 27873112-3 2017 In the case of nitrite, the calculated limits of detection (LOD) for two of the polymeric sensors (10 muM) are very close to the sensitivity estimated for free DAQ in solution (LOD 5 muM), but with the advantage of a solid supported sensor with the format of a disposable test-strip made with affordable starting chemicals. Nitrites 15-22 latexin Homo sapiens 102-105 27873112-3 2017 In the case of nitrite, the calculated limits of detection (LOD) for two of the polymeric sensors (10 muM) are very close to the sensitivity estimated for free DAQ in solution (LOD 5 muM), but with the advantage of a solid supported sensor with the format of a disposable test-strip made with affordable starting chemicals. Nitrites 15-22 latexin Homo sapiens 183-186 27973680-3 2017 IFN-gamma increased the release of nitrite, a metabolite of nitric oxide, which was augmented by PGE2 , although PGE2 by itself slightly affects nitrite release. Nitrites 35-42 interferon gamma Rattus norvegicus 0-9 27865123-6 2017 Acidified nitrite (pH 2, 0.1 mol L-1) yielded no detectable spores on the iron surface during the flushing phase after disinfection. Nitrites 10-17 immunoglobulin kappa variable 1-16 Homo sapiens 33-36 27851698-8 2017 Interestingly, nitrite treatment attenuated PAB-induced RV hypertrophy and reduced the expression of phospho-Akt in RV tissue from mice with PAB. Nitrites 15-22 thymoma viral proto-oncogene 1 Mus musculus 109-112 27851698-9 2017 In neonatal rat cardiac fibroblast, nitrite also attenuated hypoxia-induced increase in expression of phospho-Akt. Nitrites 36-43 thymoma viral proto-oncogene 1 Mus musculus 110-113 27973680-6 2017 An EP2 agonist, ONO-AE1-259-01 also augmented IFN-gamma-induced nitrite release, while an EP1 agonist, ONO-DI-004, an EP3 agonist, ONO-AE-248, or an EP4 agonist, ONO-AE1-329, did not. Nitrites 64-71 prostaglandin E receptor 2 Rattus norvegicus 3-6 27973680-6 2017 An EP2 agonist, ONO-AE1-259-01 also augmented IFN-gamma-induced nitrite release, while an EP1 agonist, ONO-DI-004, an EP3 agonist, ONO-AE-248, or an EP4 agonist, ONO-AE1-329, did not. Nitrites 64-71 interferon gamma Rattus norvegicus 46-55 28194142-7 2017 The reduction of produced nitrite to ammonium does not proceed via the canonical Nrf system because nitrite reductase NrfA is absent in the genomes of both microorganisms. Nitrites 26-33 NFKB repressing factor Homo sapiens 81-84 27973680-9 2017 Furthermore, other prostanoid receptor agonists, PGD2 , PGF2alpha , iloprost, and U-46119, slightly affected IFN-gamma-induced nitrite release. Nitrites 127-134 interferon gamma Rattus norvegicus 109-118 29104725-1 2017 The purpose of this study was to verify the influence of the genotype or haplotype (interaction) of the NOS3 polymorphisms [-786T>C, 894G>T (Glu298Asp), and intron 4b/a] on the response to multicomponent training (various capacities and motor skills) on blood pressure (BP), nitrite concentration, redox status, and physical fitness in older adult women. Nitrites 281-288 nitric oxide synthase 3 Homo sapiens 104-108 27550472-9 2017 Furthermore, Vit E successfully normalized renal MDA and nitrite concentrations, elevated GSH level, and restored CAT and SOD activities in renal tissues. Nitrites 57-64 vitrin Rattus norvegicus 13-16 28680530-5 2017 miR-Let7A overexpression significantly prevented cell death and loss of tight junction proteins and attenuated proinflammatory response and nitrite production in the bEnd.3 cells under high glucose condition. Nitrites 140-147 microRNA 615 Mus musculus 0-3 28680530-5 2017 miR-Let7A overexpression significantly prevented cell death and loss of tight junction proteins and attenuated proinflammatory response and nitrite production in the bEnd.3 cells under high glucose condition. Nitrites 140-147 microRNA let7a-1 Mus musculus 4-9 28090786-11 2017 The up-regulation of almost half of those miRNAs (miR-125a-5p, miR-146b, miR-339-3p, miR-433) was inhibited by nitrite treatment, perpetuating baseline values. Nitrites 111-118 microRNA 146b Mus musculus 63-71 28090786-11 2017 The up-regulation of almost half of those miRNAs (miR-125a-5p, miR-146b, miR-339-3p, miR-433) was inhibited by nitrite treatment, perpetuating baseline values. Nitrites 111-118 microRNA 433 Mus musculus 85-92 28090786-13 2017 Correspondingly, a rise in Irak-M transcript and protein levels occurred by nitrite treatment within the early phase of reperfusion. Nitrites 76-83 interleukin-1 receptor-associated kinase 3 Mus musculus 27-33 27815981-0 2017 Nitrite coordination in myoglobin. Nitrites 0-7 myoglobin Homo sapiens 24-33 27815981-1 2017 The coordination of nitrite in myoglobin (Mb) has been characterized by resonance Raman spectroscopy and the frequencies of the nitrite bound to the heme Fe as well to the 2-vinyl have been computed by density functional theory (DFT) calculations. Nitrites 20-27 myoglobin Homo sapiens 31-40 27815981-1 2017 The coordination of nitrite in myoglobin (Mb) has been characterized by resonance Raman spectroscopy and the frequencies of the nitrite bound to the heme Fe as well to the 2-vinyl have been computed by density functional theory (DFT) calculations. Nitrites 128-135 myoglobin Homo sapiens 31-40 27495376-8 2016 In addition, clear upregulated expression of the inducible NO synthase (iNOS) with high nitrite levels were observed in RTT fibroblasts, justifying the increased nitrotyrosine protein modifications. Nitrites 88-95 nitric oxide synthase 2 Homo sapiens 49-70 28322358-7 2017 The pH-1 and pH-2 values of the nitrite-treated samples were higher than those of the control samples (p < 0.005). Nitrites 32-39 alanine--glyoxylate and serine--pyruvate aminotransferase Homo sapiens 4-8 28322358-7 2017 The pH-1 and pH-2 values of the nitrite-treated samples were higher than those of the control samples (p < 0.005). Nitrites 32-39 polyhomeotic homolog 2 Homo sapiens 13-17 27904528-11 2016 RESULTS: The nitrite and MDA levels were higher in the RT group (2.10 +-0.62 ppm, 26.02 +-2.16 nmol/ml; p < 0.05) and lower in the EPO + RT group (1.45 +-0.12 ppm, 25.49 +-1.90 nmol/ml; p < 0.05). Nitrites 13-20 erythropoietin Rattus norvegicus 134-137 27680892-0 2016 Crocin protects human erythrocytes from nitrite-induced methemoglobin formation and oxidative damage. Nitrites 40-47 hemoglobin subunit gamma 2 Homo sapiens 56-69 27680892-6 2016 Crocin reduced the level of methemoglobin, the primary acute effect of nitrite intoxication. Nitrites 71-78 hemoglobin subunit gamma 2 Homo sapiens 28-41 26218639-5 2016 In addition, after nitrite exposure, synaptophysin (SYN) positive buttons in the visual cortex was reduced, in contrast the increase of gamma-synuclein positive cells. Nitrites 19-26 synaptophysin Mus musculus 37-50 26218639-5 2016 In addition, after nitrite exposure, synaptophysin (SYN) positive buttons in the visual cortex was reduced, in contrast the increase of gamma-synuclein positive cells. Nitrites 19-26 synaptophysin Mus musculus 52-55 26218639-5 2016 In addition, after nitrite exposure, synaptophysin (SYN) positive buttons in the visual cortex was reduced, in contrast the increase of gamma-synuclein positive cells. Nitrites 19-26 synuclein, gamma Mus musculus 136-151 27744007-3 2016 Therefore, this study tested the hypothesis that dietary NO3- supplementation would be less effective at increasing the circulating plasma nitrite concentration ([NO2-]) and lowering blood pressure in smokers (S) compared to non-smokers (NS). Nitrites 139-146 NBL1, DAN family BMP antagonist Homo sapiens 57-60 27927230-7 2016 RESULTS: NO production as measured by nitrite was significantly increased in eNOS and CAV-1F92A transduced eASCs +(5.59 +- 0.22 muM) compared to eNOS alone (4.81 +- 0.59 muM) and un-transduced control cells (0.91 +- 0.23 muM) (p < 0.05). Nitrites 38-45 nitric oxide synthase 3 Homo sapiens 77-81 27826125-0 2016 Nitroxides catalytically inhibit nitrite oxidation and heme inactivation induced by H2O2, nitrite and metmyoglobin or methemoglobin. Nitrites 33-40 hemoglobin subunit gamma 2 Homo sapiens 118-131 27495376-8 2016 In addition, clear upregulated expression of the inducible NO synthase (iNOS) with high nitrite levels were observed in RTT fibroblasts, justifying the increased nitrotyrosine protein modifications. Nitrites 88-95 nitric oxide synthase 2 Homo sapiens 72-76 27901641-1 2016 PsbO1 is exclusively nitrated when isolated thylakoid membranes are incubated in a buffer bubbled with nitrogen dioxide (NO2) containing NO2 and nitrite. Nitrites 145-152 PS II oxygen-evolving complex 1 Arabidopsis thaliana 0-5 27744114-0 2016 Nitrite-mediated reduction of macrophage NADPH oxidase activity is dependent on xanthine oxidoreductase-derived nitric oxide but independent of S-nitrosation. Nitrites 0-7 xanthine dehydrogenase Mus musculus 80-103 27744114-11 2016 However, protein levels of p47phox and p67phox subunits were reduced by nitrite in activated macrophages. Nitrites 72-79 neutrophil cytosolic factor 1 Mus musculus 27-34 27744114-11 2016 However, protein levels of p47phox and p67phox subunits were reduced by nitrite in activated macrophages. Nitrites 72-79 neutrophil cytosolic factor 2 Mus musculus 39-46 27744114-13 2016 Increased uric acid levels after nitrite and diminished NO production during XOR-inhibition with febuxostat suggest that XOR is more active during nitrite-treatment of activated macrophages and plays an important role in the bioactivation of nitrite. Nitrites 33-40 xanthine dehydrogenase Mus musculus 121-124 27744114-13 2016 Increased uric acid levels after nitrite and diminished NO production during XOR-inhibition with febuxostat suggest that XOR is more active during nitrite-treatment of activated macrophages and plays an important role in the bioactivation of nitrite. Nitrites 147-154 xanthine dehydrogenase Mus musculus 77-80 27744114-13 2016 Increased uric acid levels after nitrite and diminished NO production during XOR-inhibition with febuxostat suggest that XOR is more active during nitrite-treatment of activated macrophages and plays an important role in the bioactivation of nitrite. Nitrites 147-154 xanthine dehydrogenase Mus musculus 121-124 27744114-13 2016 Increased uric acid levels after nitrite and diminished NO production during XOR-inhibition with febuxostat suggest that XOR is more active during nitrite-treatment of activated macrophages and plays an important role in the bioactivation of nitrite. Nitrites 147-154 xanthine dehydrogenase Mus musculus 77-80 27744114-13 2016 Increased uric acid levels after nitrite and diminished NO production during XOR-inhibition with febuxostat suggest that XOR is more active during nitrite-treatment of activated macrophages and plays an important role in the bioactivation of nitrite. Nitrites 147-154 xanthine dehydrogenase Mus musculus 121-124 27593618-6 2016 RESULTS: Our results show that, in comparison to a placebo group, consumption of beetroot juice that contains 4000 mg/L NO3- results in elevated levels of salivary NO2-, nitrite NO3-, and NO. Nitrites 170-177 NBL1, DAN family BMP antagonist Homo sapiens 120-123 27613099-8 2016 eNOS gene haplotypes GCB, TCB (G-allele of 894G/T, C-allele -786T/C, B-allele of Intron 4b/4a respectively) were associated with high nitrite/nitrate levels compared to GTB in both FDRS and CHD patients (p < 0.01). Nitrites 134-141 nitric oxide synthase 3 Homo sapiens 0-4 27613099-8 2016 eNOS gene haplotypes GCB, TCB (G-allele of 894G/T, C-allele -786T/C, B-allele of Intron 4b/4a respectively) were associated with high nitrite/nitrate levels compared to GTB in both FDRS and CHD patients (p < 0.01). Nitrites 134-141 pyruvate kinase M1/2 Homo sapiens 26-29 27612628-14 2016 Moreover, PARP-1 inhibition decreased serum levels of TNF-alpha and cardiac nitrite but increased cardiac GSH contents in diabetic animals. Nitrites 76-83 poly (ADP-ribose) polymerase 1 Rattus norvegicus 10-16 27707708-9 2016 Male, but not female, CD NOS3 KO mice had reduced urinary nitrite+nitrate excretion compared with controls after 7 days of water loading. Nitrites 58-65 nitric oxide synthase 3, endothelial cell Mus musculus 25-29 27588710-4 2016 In avr P. infestans potato leaves enhanced NR gene and protein expression was tuned with the depletion of nitrate contents and the increase in nitrite supply at 3 hpi. Nitrites 143-150 NADH nitrate reductase Solanum tuberosum 43-45 27623091-9 2016 Moreover, these improvement effects of methylphenidate on SAB and the nitrite level were decreased by the administration of selective iNOS and eNOS inhibitors. Nitrites 70-77 nitric oxide synthase 2, inducible Mus musculus 134-138 27615794-7 2016 Thus, nitrite toxicity, rather than N depletion or nitrite-dependent NO production, probably causes the rfnr2 root growth defect. Nitrites 6-13 root FNR 2 Arabidopsis thaliana 104-109 27615794-8 2016 Our results strongly suggest that RFNR2 has a major role in reduction of toxic nitrite in roots. Nitrites 79-86 root FNR 2 Arabidopsis thaliana 34-39 27615794-9 2016 A specific set of genes related to nitrite reduction and the supply of reducing power responded to nitrite concomitantly, suggesting that the products of these genes act co-operatively with RFNR2 to reduce nitrite in roots. Nitrites 35-42 root FNR 2 Arabidopsis thaliana 190-195 27615794-9 2016 A specific set of genes related to nitrite reduction and the supply of reducing power responded to nitrite concomitantly, suggesting that the products of these genes act co-operatively with RFNR2 to reduce nitrite in roots. Nitrites 99-106 root FNR 2 Arabidopsis thaliana 190-195 27615794-9 2016 A specific set of genes related to nitrite reduction and the supply of reducing power responded to nitrite concomitantly, suggesting that the products of these genes act co-operatively with RFNR2 to reduce nitrite in roots. Nitrites 99-106 root FNR 2 Arabidopsis thaliana 190-195 27588710-8 2016 Presented data confirmed the importance of nitrite processed by NR in NO generation in inoculated potato leaves. Nitrites 43-50 NADH nitrate reductase Solanum tuberosum 64-66 27593859-6 2016 RESULTS: SIN-1 treatment increased arginase activity in a time- and dose-dependent manner and reciprocally decreased nitrite/nitrate production that was prevented by peroxynitrite scavenger in HUVECs. Nitrites 117-124 MAPK associated protein 1 Homo sapiens 9-14 27591667-6 2016 Although a high detecting sensitivity of 162.5muAmM(-1) for electrocatalytic oxidation of nitrite could be also obtained on the presented sensor, the sensitivity is lower than that of TOAB/ZnPp-C60/GCE (233.9muAmM(-1)) due to the change in the structure of ZnPp-C60 and the electronic interactions between GO and ZnPp-C60. Nitrites 90-97 glycine decarboxylase Homo sapiens 189-201 27258202-8 2016 In patients, we found that for higher NO range of values the respiratory function is worse and that for higher AChE range of values the RBCs nitrite content increase. Nitrites 141-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 27543351-6 2016 By evaluating the activation of RAW macrophages cultured with different types of resiquimod-loaded Ace-DEX MPs, we found that MPs of lower CAC or higher MW promoted greater nitrite production and resulted in more robust cell activation. Nitrites 173-180 angiotensin I converting enzyme Homo sapiens 99-102 27609225-0 2016 Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis. Nitrites 69-76 xanthine dehydrogenase Mus musculus 9-12 27474450-9 2016 Our results show that boosting the nitrate-nitrite-NO pathway can partly compensate for age-related disturbances in endogenous NO generation via inhibition of NADPH oxidase and modulation of ANG II receptor expression. Nitrites 43-50 angiotensinogen Rattus norvegicus 191-197 27609225-0 2016 Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis. Nitrites 69-76 nitric oxide synthase 3, endothelial cell Mus musculus 25-29 27609225-5 2016 The aim of the present study was to investigate if eNOS deficiency is associated with changes in XOR expression and activity and the possible impact on nitrite, NO and ROS homeostasis. Nitrites 152-159 nitric oxide synthase 3, endothelial cell Mus musculus 51-55 27609225-8 2016 Following an acute dose of nitrate, plasma nitrite increased more in eNOS-/- compared with wt, and this augmented response was abolished by the selective XOR inhibitor febuxostat. Nitrites 43-50 nitric oxide synthase 3, endothelial cell Mus musculus 69-73 30246999-2 2016 The results showed that ammonia nitrogen concentration decreased from 45.3 to 2.7 mg L-1 after aerobic, and nitrite nitrogen concentration increased from 0.01 to 19.6 mg L-1, while nitrite nitrogen concentration decreased from 19.6 to 1.2 mg L-1 after anoxic, which means that rapid nitrification and denitrification are successfully achieved. Nitrites 108-115 L1 cell adhesion molecule Homo sapiens 170-173 27609225-8 2016 Following an acute dose of nitrate, plasma nitrite increased more in eNOS-/- compared with wt, and this augmented response was abolished by the selective XOR inhibitor febuxostat. Nitrites 43-50 xanthine dehydrogenase Mus musculus 154-157 30246999-2 2016 The results showed that ammonia nitrogen concentration decreased from 45.3 to 2.7 mg L-1 after aerobic, and nitrite nitrogen concentration increased from 0.01 to 19.6 mg L-1, while nitrite nitrogen concentration decreased from 19.6 to 1.2 mg L-1 after anoxic, which means that rapid nitrification and denitrification are successfully achieved. Nitrites 108-115 L1 cell adhesion molecule Homo sapiens 170-173 27609225-9 2016 Livers from eNOS-/- displayed higher nitrite reducing capacity compared with wt, and this effect was attenuated by febuxostat. Nitrites 37-44 nitric oxide synthase 3, endothelial cell Mus musculus 12-16 27609225-14 2016 In conclusion, eNOS deficiency is associated with an upregulation of XOR facilitating the nitrate-nitrite-NO pathway and decreasing the generation of ROS. Nitrites 98-105 nitric oxide synthase 3, endothelial cell Mus musculus 15-19 27609225-14 2016 In conclusion, eNOS deficiency is associated with an upregulation of XOR facilitating the nitrate-nitrite-NO pathway and decreasing the generation of ROS. Nitrites 98-105 xanthine dehydrogenase Mus musculus 69-72 27078869-15 2016 Our results show that XOR is important to the cardiovascular responses to nitrite in 2K1C hypertension, and XOR inhibitors commonly used by patients may cancel this effect. Nitrites 74-81 xanthine dehydrogenase Homo sapiens 22-25 27670067-7 2016 Among the doses of nitrite evaluated, the 50 nM was proved efficient: it significantly reduced cytolysis, mitochondrial damage, and lipid peroxidation, and enhanced antioxidant enzyme activity (superoxide dismutase, catalase, and glutathione peroxidase activity) and hepatic function parameters (portal resistance, bile flow, and bromosulfophthalein clearance). Nitrites 19-26 catalase Rattus norvegicus 216-224 27280428-11 2016 ACh-induced vascular nitrate/nitrite production was in Preg+sFlt-1 and RUPP < Preg, and in RUPP+PlGF > RUPP. Nitrites 29-36 placental growth factor Rattus norvegicus 99-103 25986942-14 2016 Rats fed with nitrite-supplemented diets exhibited weaker SOX2 oesophageal staining than rats fed with normal diets. Nitrites 14-21 SRY-box transcription factor 2 Rattus norvegicus 58-62 27435510-0 2016 Reliable SERS detection of nitrite based on pH and laser irradiance-dependent diazotization through a convenient sampling micro-chamber. Nitrites 27-34 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 9-13 27435510-3 2016 In this chamber, nitrites specifically trigger a pH and laser irradiance-dependent diazotization starting from p-aminothiophenol (PATP) absorbed onto the surface of Au NPs to form p,p"-dimercaptoazobenzene (DMAB) molecules, in which the presence of NO2(-) ions above 30.7 muM (1.38 ppm) in the siphoned liquid sample can be identified relying on SERS peak (1141 cm(-1)) intensity of the emerging azo moiety. Nitrites 17-25 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 346-350 27262938-7 2016 Under acute nitrite challenge, the mRNA encoding the AMPKalpha isoforms, as well as AMPK activity, changed over time. Nitrites 12-19 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 53-57 27232376-4 2016 Coadministration of subthreshold doses of lithium (3mg/kg) with nitric oxide synthase (NOS) inhibitors reversed the effect of SIS on seizure susceptibility and decreased hippocampal nitrite levels in IC animals. Nitrites 182-189 nitric oxide synthase 1, neuronal Mus musculus 64-85 27307103-7 2016 In all cell models, interferon-gamma activation leads to up-regulation of interleukin-12 and nitrite production. Nitrites 93-100 interferon gamma Homo sapiens 20-36 27559045-12 2016 Accordingly, Mincle deletion lowered production of nitrites in Con A hepatitis and inhibition of both C/EBPbeta and HIF-1alpha reduced the severity of liver disease. Nitrites 51-59 C-type lectin domain family 4, member e Mus musculus 13-19 27553127-6 2016 Plasma nitrite concentration was significantly greater following BRJ versus PLA 1 h post supplementation, and remained higher in BRJ throughout the testing session (p < 0.01). Nitrites 7-14 POU class 2 homeobox 3 Homo sapiens 76-81 27530158-17 2016 Administration of MBM to CCl4 exposed rats significantly increased the activity level of phase I and phase II enzymes and GSH while decreased the level of TBARS, H2O2, nitrite and DNA damages in renal tissues of rat. Nitrites 168-175 C-C motif chemokine ligand 4 Rattus norvegicus 25-29 29964739-6 2016 When the dissolved oxygen was controlled between 1 to 2 mg L-1, the nitrite accumulation rate could be maintained around 90%, ensuring the stable operation of the subsequent anaerobic ammonia oxidation system. Nitrites 68-75 immunoglobulin kappa variable 1-16 Homo sapiens 59-62 27280426-4 2016 We determined that after 7 days of a high-salt diet (HS7), there was a shift to 100% ETB expression in IMCDs, as well as a twofold increase in nitrite production (a metabolite of NO), and this increase could be prevented by acute inhibition of the ETB receptor. Nitrites 143-150 endothelin receptor type B Mus musculus 248-251 27387277-6 2016 Protection was associated with the IFN-gamma production against parasite extracts, which was mediated by both CD4(+) and CD8(+) T cells and correlated with the antileishmanial nitrite production. Nitrites 176-183 interferon gamma Mus musculus 35-44 27078869-0 2016 Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension. Nitrites 71-78 xanthine dehydrogenase Rattus norvegicus 16-39 27078869-2 2016 However, XOR can generate nitric oxide (NO) from nitrite, and increased superoxide could inactivate NO formed from nitrite. Nitrites 49-56 xanthine dehydrogenase Rattus norvegicus 9-12 27078869-3 2016 This study tested the hypothesis that XOR contributes to the cardiovascular effects of nitrite in renovascular hypertension, and that treatment with the antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) improves XOR-mediated effects of nitrite. Nitrites 87-94 xanthine dehydrogenase Rattus norvegicus 38-41 27235860-5 2016 Overexpression of PGC-1alpha with adenovirus or pharmacological agonist ameliorated AngII-induced the decrease of NO generation, evidenced by the restoration of cGMP and nitrite concentration. Nitrites 170-177 PPARG coactivator 1 alpha Homo sapiens 18-28 27493647-0 2016 Molecular Underpinnings of Nitrite Effect on CymA-Dependent Respiration in Shewanella oneidensis. Nitrites 27-34 cytochrome c Shewanella oneidensis MR-1 45-49 27473036-0 2016 Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2)-Dependent Signaling in Chronic Heart Failure. Nitrites 0-7 nuclear factor, erythroid derived 2, like 2 Mus musculus 63-106 27473036-0 2016 Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2)-Dependent Signaling in Chronic Heart Failure. Nitrites 0-7 nuclear factor, erythroid derived 2, like 2 Mus musculus 108-112 27493647-4 2016 In this study, we demonstrate in the model strain, Shewanella oneidensis MR-1, that nitrite, not through nitric oxide to which it may convert, inhibits respiration of fumarate, and probably many other EAs whose reduction depends on quinol dehydrogenase CymA. Nitrites 84-91 cytochrome c Shewanella oneidensis MR-1 253-257 27493647-6 2016 If nitrite is not promptly removed, intracellular cAMP levels drop, and this impairs Crp activity. Nitrites 3-10 cAMP-activated global transcriptional regulator CRP Shewanella oneidensis MR-1 85-88 27406916-7 2016 Additionally, we found that Gas6 inhibited lipopolysaccharide (LPS)-induced nitrite production in a STAT1 and LXR pathway-dependent manner in BMDM. Nitrites 76-83 signal transducer and activator of transcription 1 Mus musculus 100-105 27406916-7 2016 Additionally, we found that Gas6 inhibited lipopolysaccharide (LPS)-induced nitrite production in a STAT1 and LXR pathway-dependent manner in BMDM. Nitrites 76-83 nuclear receptor subfamily 1, group H, member 2 Mus musculus 110-113 27406916-7 2016 Additionally, we found that Gas6 inhibited lipopolysaccharide (LPS)-induced nitrite production in a STAT1 and LXR pathway-dependent manner in BMDM. Nitrites 76-83 growth arrest specific 6 Mus musculus 28-32 27129464-3 2016 Hemoglobin, xanthine oxidoreductase and carbonic anhydrase (CA) have been reported to reduce/convert nitrite to NO. Nitrites 101-108 xanthine dehydrogenase Homo sapiens 12-35 27208107-3 2016 Nitrogen and oxygen isotope ratios of nitrite (delta(15)NNO2- and delta(18)ONO2-, respectively) are geochemical tracers for evaluating the sources and the in situ rate of nitrite turnover determined from the activities of nitrification and denitrification; however, the isotope ratios of nitrite from archaeal ammonia oxidation have been characterized only for a few marine species. Nitrites 38-45 membrane frizzled-related protein Homo sapiens 56-60 27129464-8 2016 In reduced glutathione (GSH) containing aqueous buffer (pH 7.4), human and bovine erythrocytic CAII-mediated formation of GSNO from nitrite and GS(15)NO from (15)N-nitrite. Nitrites 132-139 carbonic anhydrase 2 Bos taurus 95-99 27129464-10 2016 Incubation of nitrite with bovine erythrocytic CAII and recombinant soluble guanylyl cyclase resulted in cGMP formation. Nitrites 14-21 carbonic anhydrase 2 Bos taurus 47-51 27129464-11 2016 Upon incubation of nitrite with bovine erythrocytic CAII and washed human platelets, cGMP and P-VASP(S239) were formed in the platelets. Nitrites 19-26 carbonic anhydrase 2 Bos taurus 52-56 29897188-0 2016 [Exposure of human hepatoma cells to nitrite and ammonia promotes invasive activity through activation of ROS/ODC pathway]. Nitrites 37-44 ornithine decarboxylase 1 Homo sapiens 110-113 27013260-7 2016 The results showed that both F10 fraction and water extract were not toxic to human cells, and they were able to stimulate the nitrite production, with values of 13.6 and 5.4 muM, respectively, suggesting that their biological activity could be due to macrophages activation via NO production. Nitrites 127-134 latexin Homo sapiens 175-178 26081147-5 2016 The study therefore aimed to examine an association of neuronal NOS (nNOS) gene polymorphism with nitrite, an indicator of nitrosative load; lipid peroxidation, an index of oxidative stress and PD susceptibility. Nitrites 98-105 nitric oxide synthase 1 Homo sapiens 55-67 26081147-5 2016 The study therefore aimed to examine an association of neuronal NOS (nNOS) gene polymorphism with nitrite, an indicator of nitrosative load; lipid peroxidation, an index of oxidative stress and PD susceptibility. Nitrites 98-105 nitric oxide synthase 1 Homo sapiens 69-73 27023380-3 2016 However, at a COD/N ratio of 5.0 (COD, 300mg L(-1)), ammonium and nitrite removal efficiencies were high (84% and 99%, respectively). Nitrites 66-73 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 14-17 27023380-3 2016 However, at a COD/N ratio of 5.0 (COD, 300mg L(-1)), ammonium and nitrite removal efficiencies were high (84% and 99%, respectively). Nitrites 66-73 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 34-37 27023380-4 2016 High COD, nitrite, and ammonium removal efficiencies (80%, 90% and 95%, respectively) were obtained on adding anaerobically pre-treated municipal wastewater (with nitrite) to the reactor. Nitrites 163-170 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 5-8 27131407-3 2016 The aim of this study was to assess whether oral intake of a nitrate (NO3-)-rich dietary supplement (amaranth extract) is able to increase NO3- and nitrite (NO2-) levels in blood plasma and saliva of healthy adults. Nitrites 148-155 NBL1, DAN family BMP antagonist Homo sapiens 70-73 27233360-12 2016 CCl4 injection in rats decreased the activity level of CAT, POD, SOD, GST and gamma-GT and GSH contents while elevated levels of TBARS, H2O2 and nitrite contents were observed in renal tissues. Nitrites 145-152 C-C motif chemokine ligand 4 Rattus norvegicus 0-4 27376045-16 2016 CONCLUSION: Our findings suggest that central effect of Ang II on blood pressure is accompanied with increased levels of MDA and nitrite in the circulation. Nitrites 129-136 angiotensinogen Rattus norvegicus 56-62 27243218-10 2016 Furthermore, the concentrations of nitric oxide, nitrite, nitrate, and the ferric reducing ability of plasma decreased with AAC indicating a lower oxidative stress status. Nitrites 49-56 glycine N-acyltransferase Bos taurus 124-127 27020551-0 2016 Inhibition of myeloperoxidase-mediated oxidative damage by nitrite in SH-SY5Y cells: Relevance to neuroprotection in neurodegenerative diseases. Nitrites 59-66 myeloperoxidase Homo sapiens 14-29 26970969-7 2016 LPS administration increased the oxido-nitrosative stress as evident by elevated levels of malondialdehyde, nitrite, and depletion of glutathione level in the hippocampus. Nitrites 108-115 toll-like receptor 4 Mus musculus 0-3 26748372-0 2016 Direct electrochemistry of cytochrome c immobilized on titanium nitride/multi-walled carbon nanotube composite for amperometric nitrite biosensor. Nitrites 128-135 cytochrome c, somatic Homo sapiens 27-39 27016566-10 2016 It also provides data on the isotopic effects observed in the nitrite produced during RDX biodegradation. Nitrites 62-69 radixin Homo sapiens 86-89 26748372-4 2016 Direct electrochemistry and electrocatalysis of cytochrome c immobilized on the MWCNTs-TiN composite modified on a glassy carbon electrode for nitrite sensing are investigated. Nitrites 143-150 cytochrome c, somatic Homo sapiens 48-60 26748372-7 2016 The applicability of the as-prepared biosensor is validated by the successful detection of nitrite in tap and sea water samples. Nitrites 91-98 nuclear RNA export factor 1 Homo sapiens 102-105 26769972-3 2016 Copper nitrite reductase (CuNiR), which converts nitrite to nitric oxide in denitrification, has been extensively studied by synchrotron radiation crystallography (SRX). Nitrites 7-14 sulfiredoxin 1 Homo sapiens 164-167 27506043-3 2016 Nitrite nitrogen kept accumulating up to 800 mg L-1 when the influent COD/TN ratio was 0.8 +- 0.2, and the removal rates of TN, ammonium nitrogen and total organic carbon (TOC) were only 18.3% +- 12.2%, 84.2% +- 10.3% and 60.7% +- 10.7%, respectively. Nitrites 0-7 immunoglobulin kappa variable 1-16 Homo sapiens 50-53 27506043-4 2016 By contrast, as the influent COD/ TN ratio was increased to 2.4 +- 0.5, the accumulated concentration of nitrite nitrogen sharply decreased from 800 mg L-1 to below 10 mg-L-1, and the removal rates of TN, ammonium nitrogen and TOC were increased to over 90%, 95% and 85%, respectively. Nitrites 105-112 immunoglobulin kappa variable 1-16 Homo sapiens 154-157 27506043-4 2016 By contrast, as the influent COD/ TN ratio was increased to 2.4 +- 0.5, the accumulated concentration of nitrite nitrogen sharply decreased from 800 mg L-1 to below 10 mg-L-1, and the removal rates of TN, ammonium nitrogen and TOC were increased to over 90%, 95% and 85%, respectively. Nitrites 105-112 immunoglobulin kappa variable 1-16 Homo sapiens 173-176 26830534-8 2016 Synthetic cysteine (Cys), glutathione (GSH), N-acetylcysteine (NAC) and N-acetylcysteine ethyl ester (NACET) inhibited nitrite-induced modifications of oxyhemoglobin including methemoglobin, HbSSG (CysSH >> NACET >> GSH NAC; thiol concentration, 50 muM) and HbSNO. Nitrites 119-126 latexin Homo sapiens 263-266 27000467-1 2016 The presence of nitric oxide (NO) synthase enzymes, mainly the NOS1 isoform, in skeletal muscle had been well established; however in the last decade it has been realized that NO may also be produced by reduction of nitrate and tissue nitrite. Nitrites 235-242 nitric oxide synthase 1 Rattus norvegicus 63-67 27000467-6 2016 Using skeletal muscle tissue homogenates we established that xanthine oxidoreductase (XOR) is at least partially responsible for the generation of nitrite and/or NO from nitrate and that this effect is increased by slight lowering of pH and by other processes related to the exercise itself. Nitrites 147-154 xanthine dehydrogenase Rattus norvegicus 61-84 27000467-6 2016 Using skeletal muscle tissue homogenates we established that xanthine oxidoreductase (XOR) is at least partially responsible for the generation of nitrite and/or NO from nitrate and that this effect is increased by slight lowering of pH and by other processes related to the exercise itself. Nitrites 147-154 xanthine dehydrogenase Rattus norvegicus 86-89 26976364-4 2016 Hemoglobin, xanthine oxidoreductase and carbonic anhydrase (CA) have been reported to convert nitrite to NO. Nitrites 94-101 xanthine dehydrogenase Homo sapiens 12-35 27136534-2 2016 The ferrous-deoxy Arabidopsis Hb1 and Hb2 (AHb1 and AHb2) have been shown to reduce nitrite to NO under hypoxia. Nitrites 84-91 hemoglobin 1 Arabidopsis thaliana 30-33 27136534-2 2016 The ferrous-deoxy Arabidopsis Hb1 and Hb2 (AHb1 and AHb2) have been shown to reduce nitrite to NO under hypoxia. Nitrites 84-91 homeobox protein 2 Arabidopsis thaliana 38-41 27136534-2 2016 The ferrous-deoxy Arabidopsis Hb1 and Hb2 (AHb1 and AHb2) have been shown to reduce nitrite to NO under hypoxia. Nitrites 84-91 hemoglobin 1 Arabidopsis thaliana 43-47 27136534-2 2016 The ferrous-deoxy Arabidopsis Hb1 and Hb2 (AHb1 and AHb2) have been shown to reduce nitrite to NO under hypoxia. Nitrites 84-91 hemoglobin 2 Arabidopsis thaliana 52-56 27136534-3 2016 Here, to test the hypothesis that a six- to five-coordinate heme iron transition might mediate the control of the nitrite reduction rate, we examined distal pocket mutants of AHb1 and AHb2 for nitrite reductase activity, NO production and spectroscopic features. Nitrites 114-121 hemoglobin 1 Arabidopsis thaliana 175-179 26830534-4 2016 The mechanism likely involves inhibition of catalase activity by nitrite (IC50, 9 muM), which allows H2O2 to accumulate and oxidize Cys moieties of oxyhemoglobin and erythrocytic GSH to form HbSSG in addition to GSSG. Nitrites 65-72 latexin Homo sapiens 82-85 27062724-10 2016 After one week in culture the media nitrite content was significantly higher in loaded groups than both control and TGF-beta1 stimulated groups, suggesting this may be a major therapeutic target. Nitrites 36-43 transforming growth factor beta 1 Homo sapiens 116-125 26867575-0 2016 Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine beta-Synthase. Nitrites 12-19 cystathionine beta-synthase Homo sapiens 83-110 26791826-7 2016 DNM2 overexpression decreased nitrite production (index of NO) in both COS7 and mIMCD-3 cells by 50-75%. Nitrites 30-37 dynamin 2 Mus musculus 0-4 26791826-8 2016 mIMCD-3 cells treated with a panel of dynamin inhibitors or DNM2 siRNA displayed increased nitrite production. Nitrites 91-98 dynamin 2 Mus musculus 60-64 26929369-2 2016 Analyses of the nitrite reduction mechanism in CuNiR with conventional synchrotron radiation crystallography (SRX) have been faced with difficulties, because X-ray photoreduction changes the native structures of metal centers and the enzyme-substrate complex. Nitrites 16-23 sulfiredoxin 1 Homo sapiens 110-113 30090283-0 2016 The functional role of the structure of the dioxo-isobacteriochlorin in the catalytic site of cytochrome cd1 for the reduction of nitrite. Nitrites 130-137 CD1c molecule Homo sapiens 105-108 30090283-1 2016 Cytochrome cd1 is a key enzyme in bacterial denitrification and catalyzes one-electron reduction of nitrite (NO2-) to nitric oxide (NO) at the heme d1 center under anaerobic conditions. Nitrites 100-107 CD1c molecule Homo sapiens 11-14 30090283-10 2016 These results suggest that the heme d1 has evolved as the catalytic site of cytochrome cd1 to catalyze the nitrite reduction at the highest possible redox potential while maintaining its catalytic activity. Nitrites 107-114 CD1c molecule Homo sapiens 87-90 26682792-4 2016 RESULTS: In myocardium of HFpEF patients and ZSF1-HFpEF rats, we observed the following: 1) E-selectin and intercellular adhesion molecule-1 expression levels were upregulated; 2) NADPH oxidase 2 expression was raised in macrophages and endothelial cells but not in cardiomyocytes; and 3) uncoupling of endothelial nitric oxide synthase, which was associated with reduced myocardial nitrite/nitrate concentration, cGMP content, and PKG activity. Nitrites 383-390 cytochrome b-245 beta chain Rattus norvegicus 180-195 26921631-9 2016 PARP inhibition significantly (p<0.01 and p<0.001) reduced the elevated levels of nitrite, inflammatory markers and also normalized the depleted NAD(total) levels. Nitrites 88-95 poly (ADP-ribose) polymerase 1 Rattus norvegicus 0-4 26553125-9 2016 The heme oxygenase-1 inhibitor zinc protoporphyrin attenuated the inhibitory effect of SCF4 on lipopolysaccharide-stimulated nitrite production and expression of inflammatory mediators, tumor necrosis factor alpha, and p-STAT1. Nitrites 125-132 heme oxygenase 1 Mus musculus 4-20 26516799-0 2016 Nitrite Reduces Ischemia-Induced Ventricular Arrhythmias by Attenuating Connexin 43 Dephosphorylation in Rats. Nitrites 0-7 gap junction protein, alpha 1 Rattus norvegicus 72-83 26516799-3 2016 The present study investigates whether nitrite can attenuate ischemia-induced ventricular arrhythmias and dephosphorylation of Cx43 in a rat model. Nitrites 39-46 gap junction protein, alpha 1 Rattus norvegicus 127-131 26516799-9 2016 Immunoblotting revealed that the level of phosphorylated Cx43 in the group given 0.15 mg/kg nitrite, but not in the other treated groups, was significantly higher compared with the control group (P = 0.007). Nitrites 92-99 gap junction protein, alpha 1 Rattus norvegicus 57-61 26516799-10 2016 CONCLUSIONS: Nitrite may have attenuated acute ischemia-induced ventricular arrhythmias and Cx43 dephosphorylation in rats. Nitrites 13-20 gap junction protein, alpha 1 Rattus norvegicus 92-96 26516799-11 2016 Nitric oxide, which might be generated by xanthine oxidoreductase via nitrite reduction, appears to play a crucial role in this antiarrhythmic effect. Nitrites 70-77 xanthine dehydrogenase Rattus norvegicus 42-65 26799712-7 2016 The model simulation results also show that the sulphur term (eta(S)) in the kinetic equations of nitrate, nitrite, sulphur and sulphate remains constant, rather than being controlled by its own concentration. Nitrites 107-114 endothelin receptor type A Homo sapiens 62-65 26729042-5 2016 Using the nitrate/nitrite assay, we also demonstrated that the thrombin- and TFLLR-induced production of nitric oxide was inhibited by SCH and L-NAME, a NOS inhibitor. Nitrites 18-25 coagulation factor II, thrombin Homo sapiens 63-71 26453114-6 2016 In patients" plasma, a negative correlation associated IL-6 with circulating nitrites (r = -0.33). Nitrites 77-85 interleukin 6 Homo sapiens 55-59 26453114-8 2016 In patients" plasma, nitrite synthesis was positively associated with MMP-9 activation (r = 0.45), pro-MMP-2 expression (r = 0.37), and negatively correlated with MMP-2 activation (r = -0.51). Nitrites 21-28 matrix metallopeptidase 9 Homo sapiens 70-75 26453114-8 2016 In patients" plasma, nitrite synthesis was positively associated with MMP-9 activation (r = 0.45), pro-MMP-2 expression (r = 0.37), and negatively correlated with MMP-2 activation (r = -0.51). Nitrites 21-28 matrix metallopeptidase 2 Homo sapiens 103-108 26453114-8 2016 In patients" plasma, nitrite synthesis was positively associated with MMP-9 activation (r = 0.45), pro-MMP-2 expression (r = 0.37), and negatively correlated with MMP-2 activation (r = -0.51). Nitrites 21-28 matrix metallopeptidase 2 Homo sapiens 163-168 26813102-0 2016 SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Nitrites 49-56 sirtuin 3 Homo sapiens 0-5 26813102-5 2016 Chronic oral nitrite treatment improved hyperglycemia in obese ZSF1 rats by a process that requires skeletal muscle SIRT3-AMPK-GLUT4 signaling. Nitrites 13-20 sirtuin 3 Rattus norvegicus 116-121 26813102-5 2016 Chronic oral nitrite treatment improved hyperglycemia in obese ZSF1 rats by a process that requires skeletal muscle SIRT3-AMPK-GLUT4 signaling. Nitrites 13-20 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 122-126 26813102-5 2016 Chronic oral nitrite treatment improved hyperglycemia in obese ZSF1 rats by a process that requires skeletal muscle SIRT3-AMPK-GLUT4 signaling. Nitrites 13-20 solute carrier family 2 member 4 Rattus norvegicus 127-132 26813102-6 2016 The glucose-lowering effect of nitrite was abolished in SIRT3-deficient human skeletal muscle cells, and in SIRT3 knockout mice fed a high-fat diet, as well. Nitrites 31-38 sirtuin 3 Homo sapiens 56-61 26813102-8 2016 Finally, early treatments with nitrite and metformin at the time of SU5416 injection reduced pulmonary pressures and vascular remodeling in the PH-HFpEF model with robust activation of skeletal muscle SIRT3 and AMP-activated protein kinase. Nitrites 31-38 sirtuin 3 Homo sapiens 201-206 26607249-4 2016 Ten weeks of sodium nitrite (80 or 160 mg/day, capsules, TheraVasc; randomized, placebo control, double blind) increased plasma nitrite acutely (5- to 15-fold, P < 0.001 vs. placebo) and chronically (P < 0.10) and was well tolerated without symptomatic hypotension or clinically relevant elevations in blood methemoglobin. Nitrites 20-27 hemoglobin subunit gamma 2 Homo sapiens 314-327 26454083-0 2016 NADPH-cytochrome P450 reductase-mediated denitration reaction of 2,4,6-trinitrotoluene to yield nitrite in mammals. Nitrites 96-103 cytochrome p450 oxidoreductase Rattus norvegicus 0-31 26454083-3 2016 A NADPH-cytochrome P450 reductase (P450R) was isolated and identified from rat liver microsomes as the enzyme responsible for not only the release of nitrite from TNT but also formation of superoxide and 4-hydroxyamino-2,6-dinitrotoluene (4-HADNT) under aerobic conditions. Nitrites 150-157 cytochrome p450 oxidoreductase Rattus norvegicus 2-33 26614570-10 2016 While sodium nitrite attenuated MMP-9 production by HUVECs, adding hemoglobin (NO scavenger) did not affect the responses to nitrite. Nitrites 13-20 matrix metallopeptidase 9 Homo sapiens 32-37 26493186-9 2016 COX-2 and PPAR-gamma inhibition further increased LPS-induced release of nitrites and nitrates in TF explants and adipocytes from OB-CC patients. Nitrites 73-81 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-5 26493186-9 2016 COX-2 and PPAR-gamma inhibition further increased LPS-induced release of nitrites and nitrates in TF explants and adipocytes from OB-CC patients. Nitrites 73-81 peroxisome proliferator activated receptor gamma Homo sapiens 10-20 26673783-4 2016 Nitrite reductase is a key enzyme involved in nitrite metabolism. Nitrites 46-53 Pyrroline 5-carboyxlate reductase Drosophila melanogaster 8-17 26614570-14 2016 Our findings may help to elucidate important new nitrite-mediated mechanisms by which statins affect imbalanced MMP activity in a variety of cardiovascular disease. Nitrites 49-56 matrix metallopeptidase 9 Homo sapiens 112-115 26848050-10 2016 The presence of WC1(+) gammadelta T lymphocytes was associated with higher expression of MHC-I on MDMs and increased concentration of nitrites in supernatants 72h after Map infection. Nitrites 134-142 uncharacterized protein LOC751809 Bos taurus 16-19 26435258-3 2016 The aim of the study was to measure and correlate plasma nitrite/nitrate levels with tissue specific expression of iNOS mRNA among women with different grades of cervical lesions and cervical cancer. Nitrites 57-64 nitric oxide synthase 2 Homo sapiens 115-119 26618754-9 2016 Experiments in the presence of nitrite for both systems support the involvement of a Cbl(I)(-) intermediate in the Cbl(II)/PA reaction. Nitrites 31-38 Cbl proto-oncogene Homo sapiens 85-88 26618754-9 2016 Experiments in the presence of nitrite for both systems support the involvement of a Cbl(I)(-) intermediate in the Cbl(II)/PA reaction. Nitrites 31-38 Cbl proto-oncogene Homo sapiens 115-118 27526131-5 2016 Acidotic conditions for up to 6 h increased the iNOS expression significantly which was functional as indicated by an elevated level of nitrate/nitrite formation by 30 %. Nitrites 144-151 nitric oxide synthase 2, inducible Mus musculus 48-52 27458036-6 2016 XOR has an activating role that is essential to the pharmacological action of quinone drugs, cyadox, antiviral nucleoside analogues, allopurinol, nitrate and nitrite. Nitrites 158-165 xanthine dehydrogenase Homo sapiens 0-3 26163002-10 2015 Additional studies on mucin gene expression demonstrated down regulation of Muc5ac and Muc6 in germ free mice after nitrite treatment. Nitrites 116-123 mucin 5, subtypes A and C, tracheobronchial/gastric Mus musculus 76-82 26609554-1 2016 Nitrite intake from the consumption of cured meat and tap water was estimated for Finnish children of 1, 3 and 6 years as well as Finnish adults of 25-74 years. Nitrites 0-7 nuclear RNA export factor 1 Homo sapiens 54-57 26544504-1 2016 Globins, such as hemoglobin (Hb) and myoglobin (Mb), have gained attention for their ability to reduce nitrite (NO2(-)) to nitric oxide (NO). Nitrites 103-110 myoglobin Homo sapiens 37-46 26374946-0 2016 Role of xanthine oxidoreductase in the anti-thrombotic effects of nitrite in rats in vivo. Nitrites 66-73 xanthine dehydrogenase Rattus norvegicus 8-31 26374946-2 2016 The goal of the work described here was to investigate the role of xanthine oxidoreductase (XOR) in the anti-platelet and anti-thrombotic activities of nitrite in rats in vivo. Nitrites 152-159 xanthine dehydrogenase Rattus norvegicus 67-90 26374946-2 2016 The goal of the work described here was to investigate the role of xanthine oxidoreductase (XOR) in the anti-platelet and anti-thrombotic activities of nitrite in rats in vivo. Nitrites 152-159 xanthine dehydrogenase Rattus norvegicus 92-95 26374946-7 2016 In turn, profound anti-platelet effect of nitrite measured ex vivo using collagen-induced whole-blood platelet aggregation (70.5 +- 7.1% vs. VEH 100 +- 4.5%, p < 0.05) and dynamic thromboxaneB2 generation was fully reversed by both XOR-inhibitors. Nitrites 42-49 xanthine dehydrogenase Rattus norvegicus 235-238 26374946-11 2016 In conclusion, the nitrite-induced anti-platelet effect in rats in vivo is mediated by XOR, but XOR does not fully account for the anti-thrombotic effects of nitrite. Nitrites 19-26 xanthine dehydrogenase Rattus norvegicus 87-90 27607739-0 2016 Dietary nitrite induces occludin nitration in the stomach. Nitrites 8-15 occludin Homo sapiens 24-32 27508376-5 2016 Ammonium removal rate was up to 95% in biofilters with or without electrolysis integration with an influent ammonium concentration of 40 mg/L, and the accumulation of nitrate and nitrite was much lower in the effluent of E-BF than that of BF. Nitrites 179-186 EBF transcription factor 1 Homo sapiens 221-225 26163002-10 2015 Additional studies on mucin gene expression demonstrated down regulation of Muc5ac and Muc6 in germ free mice after nitrite treatment. Nitrites 116-123 mucin 6, gastric Mus musculus 87-91 26202471-10 2015 RBCs that oxidized nitrite faster on Day 7 were associated with the greatest levels of storage-dependent hemolysis and increases in Prx-2 oxidation. Nitrites 19-26 peroxiredoxin 2 Homo sapiens 132-137 26882687-3 2015 Compounds 2, 4 and 14 exhibited significant anti-inflammatory activity against nitrite of LPS-stimulated production in the RAW 264.7 cell line. Nitrites 79-86 toll-like receptor 4 Mus musculus 90-93 26509703-6 2015 In spite of these similarities, they catalyze very different reactions: Nap abstracts an oxygen atom from nitrate releasing nitrite, whereas FdH catalyzes a hydrogen atom transfer from formate and releases carbon dioxide. Nitrites 124-131 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 141-144 26447683-1 2015 Primary nitrogen assimilation in plants includes the reduction of nitrite to ammonium in the chloroplasts by the enzyme nitrite reductase (NiR EC:1.7.7.1) or in the plastids of non-photosynthetic organs. Nitrites 66-73 nitrite reductase 1 Arabidopsis thaliana 139-142 26447683-3 2015 The aim was to overexpress AtNiR in an attempt to alter the level of residual nitrite in the leaf which can act as precursor to the formation of nitrosamines. Nitrites 78-85 nitrite reductase 1 Arabidopsis thaliana 27-32 26605044-2 2015 In this nitrogen removal process, a complete biological denitrification from nitrate (NO3 (-)) to molecular nitrogen (N2) was achieved by four reduction steps, forming nitrite (NO2 (-)), nitric oxide (NO) and nitrous oxide (N2O) as intermediate compounds. Nitrites 168-175 NBL1, DAN family BMP antagonist Homo sapiens 86-89 26452938-5 2015 Nanocomposite coated electrode showed high sensitivity to nitrite with a detection limit of 0.1 muM. Nitrites 58-65 latexin Homo sapiens 96-99 26325324-1 2015 INTRODUCTION: Dietary nitrate (NO3-) supplementation serves as an exogenous source of nitrite (NO2-) and nitric oxide (NO) through the NO3- - NO2- - NO pathway, and may improve vascular functions during normoxia. Nitrites 86-93 NBL1, DAN family BMP antagonist Homo sapiens 31-34 26325324-1 2015 INTRODUCTION: Dietary nitrate (NO3-) supplementation serves as an exogenous source of nitrite (NO2-) and nitric oxide (NO) through the NO3- - NO2- - NO pathway, and may improve vascular functions during normoxia. Nitrites 86-93 NBL1, DAN family BMP antagonist Homo sapiens 135-138 25911044-2 2015 Results obtained show that the initial deprotonation of RDX by hydroxide leads to nitrite elimination and formation of a denitrated cyclohexene intermediate. Nitrites 82-89 radixin Homo sapiens 56-59 26044183-6 2015 Inhibition of endothelial nitric oxide synthase (eNOS) and the absence of endothelium decreased nitrite-induced relaxations in both WKY and SHR aortae, indicating the role of endothelium-derived nitric oxide (NO) in the response. Nitrites 96-103 nitric oxide synthase 3 Rattus norvegicus 14-47 26044183-8 2015 The presence of NO scavengers decreased the relaxation to nitrite in both WKY and SHR preparations while inhibition of soluble guanylyl cyclase (sGC) abolished the response, indicating that besides producing NO, nitrite also induces relaxation by directly activating the enzyme. Nitrites 212-219 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 119-143 26044183-8 2015 The presence of NO scavengers decreased the relaxation to nitrite in both WKY and SHR preparations while inhibition of soluble guanylyl cyclase (sGC) abolished the response, indicating that besides producing NO, nitrite also induces relaxation by directly activating the enzyme. Nitrites 212-219 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 145-148 26044183-10 2015 The endothelium-dependent component of the relaxation to nitrite involves activation of eNOS with production of endothelium-derived NO, while the endothelium-independent component is due to stimulation of sGC. Nitrites 57-64 nitric oxide synthase 3 Rattus norvegicus 88-92 26500455-8 2015 Treatment with a combination of IL-6, LPS, TNF-alpha, IFN- gamma and IL-1beta induced the highest nitrite secretion (2.91 fold, P < 0.01) as compared to cells incubated in medium alone. Nitrites 98-105 interleukin 6 Homo sapiens 32-36 26500455-8 2015 Treatment with a combination of IL-6, LPS, TNF-alpha, IFN- gamma and IL-1beta induced the highest nitrite secretion (2.91 fold, P < 0.01) as compared to cells incubated in medium alone. Nitrites 98-105 tumor necrosis factor Homo sapiens 43-52 26500455-8 2015 Treatment with a combination of IL-6, LPS, TNF-alpha, IFN- gamma and IL-1beta induced the highest nitrite secretion (2.91 fold, P < 0.01) as compared to cells incubated in medium alone. Nitrites 98-105 interferon gamma Homo sapiens 54-64 26500455-8 2015 Treatment with a combination of IL-6, LPS, TNF-alpha, IFN- gamma and IL-1beta induced the highest nitrite secretion (2.91 fold, P < 0.01) as compared to cells incubated in medium alone. Nitrites 98-105 interleukin 1 beta Homo sapiens 69-77 26335043-4 2015 We studied the reaction between pyrite (5-125 mM) and nitrite (40-2000 muM) at pH 0, 5.5, and 6.8 in the absence and presence of oxygen. Nitrites 54-61 latexin Homo sapiens 71-74 26276822-2 2015 In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascular eNOS expression and nitrite/nitrate synthesis. Nitrites 184-191 nitric oxide synthase 3, endothelial cell Mus musculus 85-118 26276822-2 2015 In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascular eNOS expression and nitrite/nitrate synthesis. Nitrites 184-191 nitric oxide synthase 3, endothelial cell Mus musculus 120-124 26273901-4 2015 The assignment of the NO2(-) anion ligand in these complexes, resulting in oxidation from An(V) to An(VI), is substantiated by the replacement of the acetate ligands in AnO2(CH3CO2)2(NO2)(-) and AnO2(CH3CO2)3(-) by nitrites, to produce the tris(nitrite) complexes AnO2(NO2)3(-). Nitrites 215-223 anoctamin 2 Homo sapiens 169-173 26273901-4 2015 The assignment of the NO2(-) anion ligand in these complexes, resulting in oxidation from An(V) to An(VI), is substantiated by the replacement of the acetate ligands in AnO2(CH3CO2)2(NO2)(-) and AnO2(CH3CO2)3(-) by nitrites, to produce the tris(nitrite) complexes AnO2(NO2)3(-). Nitrites 215-222 anoctamin 2 Homo sapiens 169-173 26514658-8 2015 Overall, IL-1beta, VEGF, and nitrite levels as a read out of nitric oxide production were abundant in Ins2(Akita) CX3CR1-deficient retina. Nitrites 29-36 insulin II Mus musculus 102-106 26514658-8 2015 Overall, IL-1beta, VEGF, and nitrite levels as a read out of nitric oxide production were abundant in Ins2(Akita) CX3CR1-deficient retina. Nitrites 29-36 chemokine (C-X3-C motif) receptor 1 Mus musculus 114-120 26335043-5 2015 Significant oxidation of pyrite was measured at pH 0 with a yield of 100 muM Fe(III) after 5 mM pyrite was incubated with 2000 muM nitrite for 24 h. Dissolved oxygen increased the rate at pH 0. Nitrites 131-138 latexin Homo sapiens 73-76 26335043-5 2015 Significant oxidation of pyrite was measured at pH 0 with a yield of 100 muM Fe(III) after 5 mM pyrite was incubated with 2000 muM nitrite for 24 h. Dissolved oxygen increased the rate at pH 0. Nitrites 131-138 latexin Homo sapiens 127-130 26237518-0 2015 Six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase: insights from density functional theory studies. Nitrites 26-33 cytochrome c, somatic Homo sapiens 48-60 26237518-1 2015 In this Forum Article, an extensive discussion of the mechanism of six-electron, seven-proton nitrite reduction by the cytochrome c nitrite reductase enzyme is presented. Nitrites 94-101 cytochrome c, somatic Homo sapiens 119-131 25911044-7 2015 Computational results are in a good agreement with experimental data on hydrolysis of RDX, suggesting that 4-nitro-2,4-diazabutanal, nitrite, formaldehyde, and nitrous oxide are main products for early stages of RDX decomposition under alkaline conditions. Nitrites 133-140 radixin Homo sapiens 86-89 26023227-4 2015 Plasma nitrite (NO2 (-)) concentration was increased with Arg supplementation (P < 0.05) and tended to increase with Cit supplementation (P = 0.08) compared with Pla (83 +- 25, 106 +- 41, and 100 +- 38 nM with Pla, Arg, and Cit, respectively); however, mean arterial blood pressure was only lower (P < 0.05) after Cit supplementation. Nitrites 7-14 citron rho-interacting serine/threonine kinase Homo sapiens 120-123 26221772-5 2015 We found that inflammatory factors and Reactive Oxygen Species (ROS) production levels were altered according to miR-Let-7a expression level as measured by Western blot analysis, reverse transcription PCR, quantitative real time PCR, the measurement of nitrite (indicative of the nitric oxide (NO) pathway), and immunocytochemistry (ICC). Nitrites 253-260 microRNA 615 Mus musculus 113-116 26221772-5 2015 We found that inflammatory factors and Reactive Oxygen Species (ROS) production levels were altered according to miR-Let-7a expression level as measured by Western blot analysis, reverse transcription PCR, quantitative real time PCR, the measurement of nitrite (indicative of the nitric oxide (NO) pathway), and immunocytochemistry (ICC). Nitrites 253-260 microRNA let7a-1 Mus musculus 117-123 26221772-7 2015 In response to inflammation, miR-Let-7a participates in the reduction of nitrite production and the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6 and is involved in increased expression of brain derived neurotrophic factor (BDNF), interleukin (IL)-10, and IL-4 in microglia. Nitrites 73-80 microRNA 615 Mus musculus 29-32 26221772-7 2015 In response to inflammation, miR-Let-7a participates in the reduction of nitrite production and the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6 and is involved in increased expression of brain derived neurotrophic factor (BDNF), interleukin (IL)-10, and IL-4 in microglia. Nitrites 73-80 microRNA let7a-1 Mus musculus 33-39 26221772-7 2015 In response to inflammation, miR-Let-7a participates in the reduction of nitrite production and the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6 and is involved in increased expression of brain derived neurotrophic factor (BDNF), interleukin (IL)-10, and IL-4 in microglia. Nitrites 73-80 interleukin 6 Mus musculus 154-172 26221772-7 2015 In response to inflammation, miR-Let-7a participates in the reduction of nitrite production and the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6 and is involved in increased expression of brain derived neurotrophic factor (BDNF), interleukin (IL)-10, and IL-4 in microglia. Nitrites 73-80 brain derived neurotrophic factor Mus musculus 216-249 26221772-7 2015 In response to inflammation, miR-Let-7a participates in the reduction of nitrite production and the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6 and is involved in increased expression of brain derived neurotrophic factor (BDNF), interleukin (IL)-10, and IL-4 in microglia. Nitrites 73-80 brain derived neurotrophic factor Mus musculus 251-255 26221772-7 2015 In response to inflammation, miR-Let-7a participates in the reduction of nitrite production and the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6 and is involved in increased expression of brain derived neurotrophic factor (BDNF), interleukin (IL)-10, and IL-4 in microglia. Nitrites 73-80 interleukin 10 Mus musculus 258-277 26221772-7 2015 In response to inflammation, miR-Let-7a participates in the reduction of nitrite production and the expression of inducible nitric oxide synthase (iNOS), interleukin (IL)-6 and is involved in increased expression of brain derived neurotrophic factor (BDNF), interleukin (IL)-10, and IL-4 in microglia. Nitrites 73-80 interleukin 4 Mus musculus 283-287 24224525-1 2015 AIMS: Inorganic nitrate and nitrite from endogenous and dietary sources have emerged as alternative substrates for nitric oxide (NO) formation in addition to the classic L-arginine NO synthase (NOS)-dependent pathway. Nitrites 28-35 nitric oxide synthase 1, neuronal Mus musculus 181-192 25937621-3 2015 The potential of oral NO3(-) to modify exercise/performance via elevation of plasma nitrite concentration ([NO2(-)]) has been applied across a range of human test systems. Nitrites 84-91 NBL1, DAN family BMP antagonist Homo sapiens 22-25 26172912-0 2015 Distal Histidine Modulates the Unusual O-Binding of Nitrite to Myoglobin: Evidence from the Quantum Chemical Analysis of EPR Parameters. Nitrites 52-59 myoglobin Homo sapiens 63-72 26172912-2 2015 In contrast to the commonly found N-binding motif of nitrite to iron in synthetic models, the less commonly observed O-binding of nitrite to myoglobin ( Copeland , D. M. ; Soares , A. S. ; West , A. H. ; Richter-Addo , G. B. J. Inorg. Nitrites 130-137 myoglobin Homo sapiens 141-150 26172912-8 2015 Given to the very similar active sites, there exists a controversy within the two powerful experimental techniques in identifying the coordination motif of nitrite to myoglobin, which is central to understanding the denitrification mechanism. Nitrites 156-163 myoglobin Homo sapiens 167-176 26172912-9 2015 Herein, we report the computation of spin Hamiltonian EPR parameters of different linkage isomers of nitrite bound myoglobin using wave function based "ab initio" and density functional theories to shed light on the binding motif of nitrite to ferric iron. Nitrites 101-108 myoglobin Homo sapiens 115-124 26172912-9 2015 Herein, we report the computation of spin Hamiltonian EPR parameters of different linkage isomers of nitrite bound myoglobin using wave function based "ab initio" and density functional theories to shed light on the binding motif of nitrite to ferric iron. Nitrites 233-240 myoglobin Homo sapiens 115-124 25951615-0 2015 Inhibitory effects of nitrite on the reactions of bovine carbonic anhydrase II with CO2 and bicarbonate consistent with zinc-bound nitrite. Nitrites 22-29 carbonic anhydrase 2 Bos taurus 57-78 25951615-0 2015 Inhibitory effects of nitrite on the reactions of bovine carbonic anhydrase II with CO2 and bicarbonate consistent with zinc-bound nitrite. Nitrites 131-138 carbonic anhydrase 2 Bos taurus 57-78 25951615-2 2015 Bovine CA II may also react with nitrite to generate nitric oxide, although nitrite is a known inhibitor of the CO2 hydration reaction. Nitrites 33-40 carbonic anhydrase 2 Bos taurus 7-12 25951615-7 2015 The low affinity of the enzyme for nitrite suggests that the in vivo interaction between red blood cell CA II and nitrite requires compartmentalization at the anion exchanger protein of the red cell membrane to be physiologically relevant. Nitrites 35-42 carbonic anhydrase 2 Bos taurus 104-109 25951615-7 2015 The low affinity of the enzyme for nitrite suggests that the in vivo interaction between red blood cell CA II and nitrite requires compartmentalization at the anion exchanger protein of the red cell membrane to be physiologically relevant. Nitrites 114-121 carbonic anhydrase 2 Bos taurus 104-109 25314640-0 2015 Sulfite Oxidase Catalyzes Single-Electron Transfer at Molybdenum Domain to Reduce Nitrite to Nitric Oxide. Nitrites 82-89 sulfite oxidase Homo sapiens 0-15 25722172-0 2015 Nitrite detection in meat products samples by square-wave voltammetry at a new single walled carbon naonotubes--myoglobin modified electrode. Nitrites 0-7 myoglobin Homo sapiens 112-121 26321266-3 2015 Despite this long standing association between increased vascular XOR activity and negative clinical outcomes, recent reports reveal a new paradigm whereby the enzymatic activity of XOR mediates beneficial outcomes by catalyzing the one electron reduction of nitrite (NO2(-)) to nitric oxide (NO) when NO2(-) and/or nitrate (NO3(-)) levels are enhanced either via dietary or pharmacologic means. Nitrites 259-266 xanthine dehydrogenase Homo sapiens 66-69 26321266-3 2015 Despite this long standing association between increased vascular XOR activity and negative clinical outcomes, recent reports reveal a new paradigm whereby the enzymatic activity of XOR mediates beneficial outcomes by catalyzing the one electron reduction of nitrite (NO2(-)) to nitric oxide (NO) when NO2(-) and/or nitrate (NO3(-)) levels are enhanced either via dietary or pharmacologic means. Nitrites 259-266 xanthine dehydrogenase Homo sapiens 182-185 25722172-4 2015 The use of the sensor for the detection of nitrite ions in samples of meat products leads to comparable results with those obtained with the standard Griess spectrophotometric assay (ISO 2918/1975), proving the suitability of using immobilized myoglobin as electrocatalyst in the nitrite reduction process. Nitrites 43-50 myoglobin Homo sapiens 244-253 25722172-4 2015 The use of the sensor for the detection of nitrite ions in samples of meat products leads to comparable results with those obtained with the standard Griess spectrophotometric assay (ISO 2918/1975), proving the suitability of using immobilized myoglobin as electrocatalyst in the nitrite reduction process. Nitrites 280-287 myoglobin Homo sapiens 244-253 25754766-2 2015 In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation under normoxia and hypoxia in the rat and human vasculature. Nitrites 80-87 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 44-68 26177100-5 2015 Our second aim was to find a possible association between ACE gene polymorphism and inflammatory mediators (as interleukin (IL)-6) and/or cellular cytotoxicity induced by serum nitrite (as a breakdown product of the cytotoxic nitric oxide) in vitiligo patients. Nitrites 177-184 angiotensin I converting enzyme Homo sapiens 58-61 26177100-5 2015 Our second aim was to find a possible association between ACE gene polymorphism and inflammatory mediators (as interleukin (IL)-6) and/or cellular cytotoxicity induced by serum nitrite (as a breakdown product of the cytotoxic nitric oxide) in vitiligo patients. Nitrites 177-184 interleukin 6 Homo sapiens 111-129 26161958-7 2015 At the 50 m site, nitrite concentration decreased fivefold from 1 to 0.2 muM in just 30 hours accompanied by decreasing oxygen and increasing nitrate concentrations. Nitrites 18-25 latexin Homo sapiens 73-76 25818356-1 2015 PdCo alloy nanoparticle-embedded carbon nanofiber (PdCo/CNF) prepared by electrospinning and thermal treatment was employed as a high-performance platform for the determination of hydrogen peroxide and nitrite. Nitrites 202-209 NPHS1 adhesion molecule, nephrin Homo sapiens 56-59 25818356-4 2015 The proposed PdCo/CNF-based biosensor showed excellent analytical performances toward hydrogen peroxide (detection limit: 0.1 muM; linear range: 0.2 muM-23.5 mM) and nitrite (detection limit: 0.2 muM; linear range: 0.4-30 muM and 30-400 muM). Nitrites 166-173 NPHS1 adhesion molecule, nephrin Homo sapiens 18-21 25754766-2 2015 In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation under normoxia and hypoxia in the rat and human vasculature. Nitrites 80-87 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 70-75 25754766-3 2015 EXPERIMENTAL APPROACH: The role of ALDH2 in vascular responses to nitrite was studied using rat thoracic aorta and gluteal subcutaneous fat resistance vessels from patients with heart failure (HF; 16 patients) in vitro and by measurement of changes in forearm blood flow (FBF) during intra-arterial nitrite infusion (21 patients) in vivo. Nitrites 66-73 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 35-40 25754766-6 2015 KEY RESULTS: Both in rat aorta and human resistance vessels, dilatation to nitrite was diminished following ALDH2 inhibition, in particular under hypoxia. Nitrites 75-82 aldehyde dehydrogenase 2 family member Homo sapiens 108-113 25754766-8 2015 CONCLUSIONS AND IMPLICATIONS: In human and rat vascular tissue in vitro, hypoxic nitrite-mediated vasodilatation involves ALDH2. Nitrites 81-88 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 122-127 25841777-6 2015 During normoxia significant vasodilatation (15+-3%) was observed only at the highest concentration of nitrite, which was dependent on NO-sGC-cGMP signaling. Nitrites 102-109 sarcoglycan beta Homo sapiens 137-140 25841777-9 2015 Moreover, inhibition of various enzymatic systems reported to reduce nitrite in other vascular beds, i.e., aldehyde oxidase (raloxifene), aldehyde dehydrogenase (cyanamide), and NO synthase (L-NAME), had no effect on the nitrite response. Nitrites 69-76 aldehyde oxidase 1 Homo sapiens 107-123 25841777-10 2015 However, inhibition of xanthine oxidoreductase (XOR; febuxostat or allopurinol) abolished the sensitized response to nitrite during hypoxia and acidosis. Nitrites 117-124 xanthine dehydrogenase Homo sapiens 23-46 25841777-10 2015 However, inhibition of xanthine oxidoreductase (XOR; febuxostat or allopurinol) abolished the sensitized response to nitrite during hypoxia and acidosis. Nitrites 117-124 xanthine dehydrogenase Homo sapiens 48-51 26175726-6 2015 STC is also involved in the electron transfer pathway to reduce nitrite by interaction with the octaheme tetrathionate reductase (OTR), but not with cytochrome c nitrite reductase (ccNiR). Nitrites 64-71 tetrathionate reductase family octaheme c-type cytochrome Shewanella oneidensis MR-1 96-128 25902041-4 2015 Data from 832 human subjects revealed that heterozygous and homozygous Arg972 IRS-1 carriers had significantly lower levels of plasma eNOS and nitrite/nitrate than the homozygous wild-type (WT) IRS-1 carriers. Nitrites 143-150 insulin receptor substrate 1 Homo sapiens 78-83 25902041-9 2015 On the whole, our in vivo data demonstrate that Arg972 IRS-1 is associated with decreased plasma eNOS and nitrite/nitrate levels in human subjects. Nitrites 106-113 insulin receptor substrate 1 Homo sapiens 48-60 26161984-0 2015 Nitrite Modification of Extracellular Matrix Alters CD46 Expression and VEGF Release in Human Retinal Pigment Epithelium. Nitrites 0-7 CD46 molecule Homo sapiens 52-56 26161984-0 2015 Nitrite Modification of Extracellular Matrix Alters CD46 Expression and VEGF Release in Human Retinal Pigment Epithelium. Nitrites 0-7 vascular endothelial growth factor A Homo sapiens 72-76 26161984-2 2015 Herein we investigated the effect of nitrite modification of the extracellular matrix (ECM) as an in vitro model of "aging" and its effect on CD46 expression and vascular endothelial growth factor (VEGF) release in cocultured human retinal pigment epithelium (RPE). Nitrites 37-44 CD46 molecule Homo sapiens 142-146 26161984-2 2015 Herein we investigated the effect of nitrite modification of the extracellular matrix (ECM) as an in vitro model of "aging" and its effect on CD46 expression and vascular endothelial growth factor (VEGF) release in cocultured human retinal pigment epithelium (RPE). Nitrites 37-44 vascular endothelial growth factor A Homo sapiens 162-196 26161984-8 2015 Nitrite modification of ECM reduced the expression of CD46 on ARPE-19 cells by 0.5-fold (P = 0.003) and increased VEGF release in ARPE-19 cells by 1.7-fold (P < 0.001). Nitrites 0-7 CD46 molecule Homo sapiens 54-58 26161984-8 2015 Nitrite modification of ECM reduced the expression of CD46 on ARPE-19 cells by 0.5-fold (P = 0.003) and increased VEGF release in ARPE-19 cells by 1.7-fold (P < 0.001). Nitrites 0-7 vascular endothelial growth factor A Homo sapiens 114-118 26161984-10 2015 CONCLUSIONS: Nitrite modification of the ECM decreased CD46 expression and increased the release of VEGF from ARPE-19 cells. Nitrites 13-20 CD46 molecule Homo sapiens 55-59 26161984-10 2015 CONCLUSIONS: Nitrite modification of the ECM decreased CD46 expression and increased the release of VEGF from ARPE-19 cells. Nitrites 13-20 vascular endothelial growth factor A Homo sapiens 100-104 26175726-6 2015 STC is also involved in the electron transfer pathway to reduce nitrite by interaction with the octaheme tetrathionate reductase (OTR), but not with cytochrome c nitrite reductase (ccNiR). Nitrites 64-71 tetrathionate reductase family octaheme c-type cytochrome Shewanella oneidensis MR-1 130-133 25724690-13 2015 However, nitrite attenuated LPS-induced upregulation of iNOS expression. Nitrites 9-16 nitric oxide synthase 2 Homo sapiens 56-60 26091235-3 2015 Recently accumulated evidence has demonstrated that dietary intake of fruits and vegetables rich in nitrate/nitrite is an inexpensive and easily-practicable way to prevent insulin resistance and vascular endothelial dysfunction by increasing the NO availability; a NO-rich diet may also prevent other lifestyle-related diseases, including osteoporosis, chronic obstructive pulmonary disease (COPD), and cancer. Nitrites 108-115 insulin Homo sapiens 172-179 25955505-8 2015 An excellent electrocatalytic response of the immobilized Mb toward nitrite in the absence of electron transfer mediators was observed. Nitrites 68-75 myoglobin Homo sapiens 58-60 25797370-7 2015 PRL of 60kDa released by monocytes exhibited bioactivity in Nb2 cells, and both synthesized PRL and synthesized PRLr were related with nitrite and proinflammatory cytokine levels proapoptotic activity in CFP-M. bovis-induced monocytes. Nitrites 135-142 prolactin receptor Homo sapiens 112-116 25797370-7 2015 PRL of 60kDa released by monocytes exhibited bioactivity in Nb2 cells, and both synthesized PRL and synthesized PRLr were related with nitrite and proinflammatory cytokine levels proapoptotic activity in CFP-M. bovis-induced monocytes. Nitrites 135-142 prolactin Homo sapiens 92-95 25745028-2 2015 The Fd-NiR reaction produces ammonia from nitrite, and the activity is usually measured by nitrite disappearance. Nitrites 42-49 ferredoxin--nitrite reductase, chloroplastic Zea mays 7-10 25745028-2 2015 The Fd-NiR reaction produces ammonia from nitrite, and the activity is usually measured by nitrite disappearance. Nitrites 91-98 ferredoxin--nitrite reductase, chloroplastic Zea mays 7-10 25694484-6 2015 ANG II also increased renal production of ROS and urinary excretion of thiobarburic acid-reactive substances and reduced the activity of antioxidants and urinary excretion of nitrite/nitrate and the 17beta-estradiol metabolite 2-methoxyestradiol in Cyp1b1(-/-) but not Cyp1b1(+/+) mice. Nitrites 175-182 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 0-6 25881506-5 2015 NS398, a selective COX-2 inhibitor, reduced nitrite levels. Nitrites 44-51 mitochondrially encoded cytochrome c oxidase II Homo sapiens 19-24 25991919-1 2015 BACKGROUND AND AIM: The ability of inorganic nitrate and nitrite to convert to nitric oxide (NO), and some of its properties e.g. regulation of glucose metabolism, vascular homeostasis, and insulin signaling pathway, have recently raised the hypothesis that inorganic nitrate and nitrite could be potential therapeutic agents in type 2 diabetes. Nitrites 280-287 insulin Homo sapiens 190-197 25666609-9 2015 In its ferrous deoxy form, GLB-33 GD is capable of reversibly binding O2 with a very high affinity and of reducing nitrite to nitric oxide faster than other globins. Nitrites 115-122 GLoBin related Caenorhabditis elegans 27-33 25609426-10 2015 Exercise reduced 25, 75, and 50% of the IL-1beta plus IFN-gamma-induced iNOS, nitrite, and cleaved caspase-3 content, respectively, in pancreatic islets. Nitrites 78-85 interleukin 1 beta Mus musculus 40-48 25609426-10 2015 Exercise reduced 25, 75, and 50% of the IL-1beta plus IFN-gamma-induced iNOS, nitrite, and cleaved caspase-3 content, respectively, in pancreatic islets. Nitrites 78-85 interferon gamma Mus musculus 54-63 25897643-1 2015 A combination of electron paramagnetic resonance (EPR) spectroscopy and computational approaches has provided insight into the nature of the reaction coordinate for the one-electron reduction of nitrite by the mitochondrial amidoxime reducing component (mARC) enzyme. Nitrites 195-202 activity regulated cytoskeletal-associated protein Mus musculus 254-258 25637482-8 2015 In vitro experiments revealed that MPTP and MPP(+) act directly on monocytes to elicit a proinflammatory response that is, in part, dependent on the MyD88/NF-kappaB signaling pathway resulting in nitrite and proinflammatory cytokine production. Nitrites 196-203 myeloid differentiation primary response gene 88 Mus musculus 149-154 25637482-8 2015 In vitro experiments revealed that MPTP and MPP(+) act directly on monocytes to elicit a proinflammatory response that is, in part, dependent on the MyD88/NF-kappaB signaling pathway resulting in nitrite and proinflammatory cytokine production. Nitrites 196-203 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 155-164 25731855-4 2015 The efficiency of MPO to remove peroxynitrite was enhanced by L-tyrosine, nitrite and (-)-epicatechin, substances known to reduce Compound II with high reaction rate. Nitrites 38-45 myeloperoxidase Homo sapiens 18-21 25658043-1 2015 Cytochrome c nitrite reductases perform a key step in the biogeochemical N-cycle by catalyzing the six-electron reduction of nitrite to ammonium. Nitrites 13-20 cytochrome c, somatic Homo sapiens 0-12 25387246-3 2015 Recently, we found that increasing pseudoperoxidase activity induces elevated tyrosine nitration on Abeta in the presence of nitrite and hydrogen peroxide. Nitrites 125-132 amyloid beta precursor protein Homo sapiens 100-105 26262665-2 2015 This approach exploits the advantages of combined SERS/surface-enhanced resonant Raman Scattering (SERRS) by inducing the formation of homogeneous hot spots and a colored complex in resonance with the laser line, to yield detection limits for nitrite down to the subpicomolar level. Nitrites 243-250 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 50-97 26262665-2 2015 This approach exploits the advantages of combined SERS/surface-enhanced resonant Raman Scattering (SERRS) by inducing the formation of homogeneous hot spots and a colored complex in resonance with the laser line, to yield detection limits for nitrite down to the subpicomolar level. Nitrites 243-250 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 99-104 25631166-7 2015 The method has been further validated by applying it for the determination of nitrite anions in real samples, including tap water, lake water, and cured meat. Nitrites 78-85 nuclear RNA export factor 1 Homo sapiens 120-123 25568897-4 2015 The effects of pH value and detection potential on the current responses of Cu/f-RGO/GCE towards nitrite were optimized to obtain the maximal sensitivity. Nitrites 97-104 guanylate cyclase 2E, pseudogene Homo sapiens 85-88 25501648-10 2015 Nitrite circumvents the rapamycin induced attenuation of myoblast proliferation and enhances mTOR activity. Nitrites 0-7 mechanistic target of rapamycin kinase Mus musculus 93-97 25568897-9 2015 In this paper, not only did the Cu/f-RGO/GCE show high performance for determination of nitrite, but also it was simple to prepare, user-friendly and cost-effective. Nitrites 88-95 guanylate cyclase 2E, pseudogene Homo sapiens 41-44 25262340-0 2015 MWCNT-cysteamine-Nafion modified gold electrode based on myoglobin for determination of hydrogen peroxide and nitrite. Nitrites 110-117 myoglobin Homo sapiens 57-66 25262340-1 2015 In this work, a novel amperometric biosensor of hydrogen peroxide (H2O2) was developed based on the immobilization of myoglobin (Mb) on the surface of the multi-walled carbon nanotube (MWCNT) -Nafion-cysteamine (CA) modified gold electrode (Au) and its electrocatalytic activity was used for the determination of nitrite (NO2(-)). Nitrites 313-320 myoglobin Homo sapiens 118-127 25461271-7 2015 Dietary nitrite dose-dependently reduced the size of the hypertrophic adipocytes and TNF-alpha transcription in the adipose tissue of KKA(y) diabetic mice, which also restored the insulin-mediated signal transduction, including p85 and Akt phosphorylation, and subsequently restored the GLUT4 expression in the skeletal muscles. Nitrites 8-15 tumor necrosis factor Mus musculus 85-94 24943287-0 2015 The effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescents. Nitrites 60-67 nitric oxide synthase 3 Homo sapiens 15-48 24943287-1 2015 Obesity and the nitric oxide synthase 3 (NOS3) gene polymorphisms are associated with nitrite levels and hypertension. Nitrites 86-93 nitric oxide synthase 3 Homo sapiens 16-39 24943287-1 2015 Obesity and the nitric oxide synthase 3 (NOS3) gene polymorphisms are associated with nitrite levels and hypertension. Nitrites 86-93 nitric oxide synthase 3 Homo sapiens 41-45 24943287-2 2015 However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity. Nitrites 111-118 nitric oxide synthase 3 Homo sapiens 49-53 25451639-6 2015 When activated with LPS and IFNgamma, macrophages from Gch1(fl/fl)Tie2cre mice induced iNOS protein in a manner indistinguishable from wild-type controls, but produced no detectable NO, as judged by L-citrulline production, EPR spin trapping of NO, and by nitrite accumulation. Nitrites 256-263 GTP cyclohydrolase 1 Mus musculus 55-59 25554946-1 2015 Neuroglobin (Ngb) is a six-coordinate globin that can catalyze the reduction of nitrite to nitric oxide. Nitrites 80-87 neuroglobin Homo sapiens 0-11 25554946-1 2015 Neuroglobin (Ngb) is a six-coordinate globin that can catalyze the reduction of nitrite to nitric oxide. Nitrites 80-87 neuroglobin Homo sapiens 13-16 25554946-3 2015 We have shown that the H64L Ngb mutation increases the rate of nitrite reduction by 2000-fold compared to that of wild-type Ngb [Tiso, M., et al. Nitrites 63-70 neuroglobin Homo sapiens 28-31 25554946-12 2015 This suggests a relationship between the nitrite reduction rate and heme accessibility in Ngb, particularly marked for His64(E7) mutants. Nitrites 41-48 neuroglobin Homo sapiens 90-93 25461271-7 2015 Dietary nitrite dose-dependently reduced the size of the hypertrophic adipocytes and TNF-alpha transcription in the adipose tissue of KKA(y) diabetic mice, which also restored the insulin-mediated signal transduction, including p85 and Akt phosphorylation, and subsequently restored the GLUT4 expression in the skeletal muscles. Nitrites 8-15 extracellular matrix protein 1 Mus musculus 228-231 25461271-7 2015 Dietary nitrite dose-dependently reduced the size of the hypertrophic adipocytes and TNF-alpha transcription in the adipose tissue of KKA(y) diabetic mice, which also restored the insulin-mediated signal transduction, including p85 and Akt phosphorylation, and subsequently restored the GLUT4 expression in the skeletal muscles. Nitrites 8-15 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 287-292 26656812-6 2015 Hydrogen peroxide, oxygen, and nitrite were electrochemically catalyzed by the Mb-CA"s composite film with significant lowering of the reduction overpotential. Nitrites 31-38 myoglobin Homo sapiens 79-81 26451288-3 2015 Recently, we employed a combined histological, metabolomics, and transcriptional and protein analysis approach to establish that nitrate promoted the "browning" of white adipose tissue via the xanthine oxidoreductase catalyzed reductive nitrate-nitrite-nitric oxide pathway. Nitrites 245-252 xanthine dehydrogenase Homo sapiens 193-216 26063009-5 2015 In the present method, nitrite can be selectively detected down to 1 muM over several anions, such as nitrate, perchlorate, sulfate, fluoride, chloride, and bromide at mM levels. Nitrites 23-30 latexin Homo sapiens 69-72 24840342-3 2015 Pretreatment of RBCs with the PKC inhibitor chelerythrine, prior to the addition of phorbol-12-myristate-13-acetate (PMA), an activator of PKC, blocks the appearance of the morphology alterations and the sustained decrease in nitrates and nitrites levels induced by PMA. Nitrites 239-247 proline rich transmembrane protein 2 Homo sapiens 30-33 25053090-5 2015 In addition, betacyanins reduced the nitrite-level in the low concentration range of 2.5-20 muM. Nitrites 37-44 latexin Homo sapiens 92-95 25922551-5 2015 The inflammatory response expressed by PTX3 had a significant relationship with age, heart failure, infarct size, impaired flow in the infarct-related artery, and renal function and positively correlated with neopterin, TNF-alpha, 8-hydroxy-2"-deoxyguanosine, and nitrite/nitrate. Nitrites 264-271 pentraxin 3 Homo sapiens 39-43 25764971-6 2015 In the absence of the essential autophagy gene Atg7, macrophage populations are increased and key functions such as phagocytosis and nitrite burst are reduced, while the inflammatory cytokine response is significantly increased - a phenotype also observed in aged macrophages. Nitrites 133-140 autophagy related 7 Mus musculus 47-51 25664261-3 2015 In this study, we evaluated the effect of inducible NO synthase (iNOS) inhibitor, aminoguanidine (AG), on hemodynamic parameters and serum nitrite concentration in decompensated hemorrhagic shock model in normotensive and hypertensive male rats. Nitrites 139-146 nitric oxide synthase 2 Rattus norvegicus 65-69 25312440-3 2015 We investigated the hypothesis that inorganic nitrate and nitrite attenuate reactivity of renal microcirculation and blood pressure responses to angiotensin II (ANG II) by modulating nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NO bioavailability. Nitrites 58-65 angiotensinogen Homo sapiens 145-159 25312440-3 2015 We investigated the hypothesis that inorganic nitrate and nitrite attenuate reactivity of renal microcirculation and blood pressure responses to angiotensin II (ANG II) by modulating nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NO bioavailability. Nitrites 58-65 angiotensinogen Homo sapiens 161-167 25312440-5 2015 Contractions to ANG II (34%) and simultaneous NO synthase inhibition (56%) were attenuated by nitrite (18% and 26%). Nitrites 94-101 angiotensinogen Homo sapiens 16-22 25312440-6 2015 In a model of oxidative stress (superoxide dismutase-1 knockouts), abnormal ANG II-mediated arteriolar contractions (90%) were normalized by nitrite (44%). Nitrites 141-148 superoxide dismutase 1 Homo sapiens 32-54 25312440-6 2015 In a model of oxidative stress (superoxide dismutase-1 knockouts), abnormal ANG II-mediated arteriolar contractions (90%) were normalized by nitrite (44%). Nitrites 141-148 angiotensinogen Homo sapiens 76-82 25312440-10 2015 In preglomerular vascular smooth muscle cells and kidney cortex, nitrite reduced both basal and ANG II-induced NADPH oxidase activity. Nitrites 65-72 angiotensinogen Homo sapiens 96-102 26252500-12 2015 Thus, when cells are assimilating nitrate and NO appears (i.e. as a consequence of nitrite accumulation), THB1 has a double role: 1) to scavenge NO avoiding its toxic effects and 2) to control the nitrate reduction activity. Nitrites 83-90 uncharacterized protein Chlamydomonas reinhardtii 106-110 25878398-4 2015 Interestingly, the NOS3 -786TT genotype was associated with increased nitrite/nitrate levels only in IEI patients. Nitrites 70-77 nitric oxide synthase 3 Homo sapiens 19-23 25878398-8 2015 Here, we first demonstrate that NOS3 -786T>C variant affects nitrite/nitrate levels in IEI patients and that screening for NOS2A -2.5 kb (CCTTT) n polymorphism may be useful for differential diagnosis of various IEI. Nitrites 64-71 nitric oxide synthase 3 Homo sapiens 32-36 25059539-8 2015 Insulin and gliclazide have significantly attenuated, naloxone induced behavioral changes like jumping and rearing frequency, forepaw licking, wet dog shake, sneezing, straightening, circling, OMWS, and various biochemical impairments such as serum glucose, brain MDA, GSH, nitrite/nitrate, and Ca(+2) in morphine-dependent animals (invivo). Nitrites 274-281 insulin Canis lupus familiaris 0-7