PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2512987-2	1989	Intestinal DAO, in analogy with lipoprotein lipase (another heparin-released enzyme), is believed to be electrostatically linked to endothelial binding sites composed of a glycosaminoglycan (GAG) which is presumably heparan sulphate, but the complete mechanism of enzyme release is not known.	Heparitin Sulfate	216-232	amine oxidase, copper containing 1	Rattus norvegicus	11-14
2512987-2	1989	Intestinal DAO, in analogy with lipoprotein lipase (another heparin-released enzyme), is believed to be electrostatically linked to endothelial binding sites composed of a glycosaminoglycan (GAG) which is presumably heparan sulphate, but the complete mechanism of enzyme release is not known.	Heparitin Sulfate	216-232	lipoprotein lipase	Rattus norvegicus	32-50
2512987-4	1989	Heparan sulphate, a compound with the same hexosamine as heparin but with a lower concentration of sulphated iduronic acid, induced a very high release of DAO (3-fold less than heparin), while the other tested GAGs, composed of higher proportions of non sulphated uronic acid and with galactosamine instead of glucosamine, induced a significantly lower release.	Heparitin Sulfate	0-16	amine oxidase, copper containing 1	Rattus norvegicus	155-158
2512987-5	1989	In rats treated with 60 mg heparan sulphate the significant decrease in ileal mucosal DAO activity indicates that, in analogy with heparin, the high plasma enzymatic activity induced is of enterocytic origin.	Heparitin Sulfate	27-43	amine oxidase, copper containing 1	Rattus norvegicus	86-89
2512987-3	1989	In this study we assayed in rats the DAO-releasing capability of heparan sulphate, dermatan sulphate, chondroitin sulphate A and hyaluronic acid, all heparin related compounds.	Heparitin Sulfate	65-81	amine oxidase, copper containing 1	Rattus norvegicus	37-40
2612912-6	1989	We suggest that free fatty acids (FFA) and heparin to some extent share the same site of interaction on the LPL molecule; and that a high local concentration of FFA can displace LPL from its site of action--the vascular endothelium--by competing for binding to heparan sulfate.	Heparitin Sulfate	261-276	lipoprotein lipase	Cavia porcellus	108-111
2612912-6	1989	We suggest that free fatty acids (FFA) and heparin to some extent share the same site of interaction on the LPL molecule; and that a high local concentration of FFA can displace LPL from its site of action--the vascular endothelium--by competing for binding to heparan sulfate.	Heparitin Sulfate	261-276	lipoprotein lipase	Cavia porcellus	178-181
2519615-2	1989	Syndecan, a heparan sulfate-rich integral membrane proteoglycan, functions as a matrix receptor by binding cells to interstitial collagens, fibronectin, and thrombospondin.	Heparitin Sulfate	12-27	syndecan 1	Homo sapiens	0-8
2629459-4	1989	In a separate series of experiments, treatments of endothelial cells with interleukin 1 beta and tumor necrosis factor alpha, physiological mediators of immunologic and inflammatory responses, were shown to cause an inhibition of the synthesis of endothelial cell surface heparan sulfate.	Heparitin Sulfate	272-287	interleukin 1 beta	Homo sapiens	74-124
2533389-3	1989	Interaction of tetranectin with chondroitin sulphate A, B, and C, heparan sulphate and trypan blue could be demonstrated by crossed immunoelectrophoresis against monospecific rabbit anti-tetranectin.	Heparitin Sulfate	66-82	C-type lectin domain family 3 member B	Homo sapiens	15-26
2509487-1	1989	Cultured monolayers of NMuMG mouse mammary epithelial cells have augmented amounts of cell surface chondroitin sulfate glycosaminoglycan (GAG) when cultured in transforming growth factor-beta (TGF-beta), presumably because of increased synthesis on their cell surface proteoglycan (named syndecan), previously shown to contain chondroitin sulfate and heparan sulfate GAG.	Heparitin Sulfate	351-366	transforming growth factor, beta 1	Mus musculus	193-201
2509487-4	1989	Characterization of purified syndecan confirms the enhanced addition of chondroitin sulfate in TGF-beta: (a) radiosulfate incorporation into chondroitin sulfate is increased 6.2-fold in this proteoglycan fraction and heparan sulfate is increased 1.8-fold, despite no apparent increase in amount of core protein per cell, and (b) the size and density of the proteoglycan are increased, but reduced by removal of chondroitin sulfate.	Heparitin Sulfate	217-232	transforming growth factor, beta 1	Mus musculus	95-103
2529852-0	1989	Effect of a heparan sulphate with high affinity for antithrombin III upon inactivation of thrombin and coagulation factor Xa.	Heparitin Sulfate	12-28	serpin family C member 1	Homo sapiens	52-68
2688761-3	1989	There is evidence for an analogous acceleratory mechanism in vivo, that functions by the binding of antithrombin to a subpopulation of heparan sulphate proteoglycans intercalated in the surface of endothelial cells.	Heparitin Sulfate	135-151	serpin family C member 1	Homo sapiens	100-112
2529263-2	1989	Polyclonal heparan sulfate antibodies were produced by immunizing rabbits with HSPG purified from the Engelbreth-Holm-Swarm mouse tumor; these antibodies stained rat intestinal basement membranes.	Heparitin Sulfate	11-26	syndecan 2	Mus musculus	79-83
2679069-7	1989	It is concluded that the effect of warfarin on hemostatic system activation is modulated by the endogenous heparan sulfate-ATIII mechanism.	Heparitin Sulfate	107-122	serpin family C member 1	Homo sapiens	123-128
2529852-0	1989	Effect of a heparan sulphate with high affinity for antithrombin III upon inactivation of thrombin and coagulation factor Xa.	Heparitin Sulfate	12-28	coagulation factor II, thrombin	Homo sapiens	56-64
2529852-0	1989	Effect of a heparan sulphate with high affinity for antithrombin III upon inactivation of thrombin and coagulation factor Xa.	Heparitin Sulfate	12-28	coagulation factor X	Homo sapiens	115-124
2529852-1	1989	The kinetics of inhibition of human alpha-thrombin and coagulation Factor Xa by antithrombin III were examined under pseudo-first-order reaction conditions as a function of the concentration of heparan sulphate with high affinity for antithrombin III.	Heparitin Sulfate	194-210	coagulation factor II, thrombin	Homo sapiens	42-50
2529852-1	1989	The kinetics of inhibition of human alpha-thrombin and coagulation Factor Xa by antithrombin III were examined under pseudo-first-order reaction conditions as a function of the concentration of heparan sulphate with high affinity for antithrombin III.	Heparitin Sulfate	194-210	serpin family C member 1	Homo sapiens	80-96
2529852-1	1989	The kinetics of inhibition of human alpha-thrombin and coagulation Factor Xa by antithrombin III were examined under pseudo-first-order reaction conditions as a function of the concentration of heparan sulphate with high affinity for antithrombin III.	Heparitin Sulfate	194-210	serpin family C member 1	Homo sapiens	234-250
2529852-10	1989	It was observed that the apparent binding affinity for thrombin was higher for heparan sulphate (180 nM) than for heparin (14 nM).	Heparitin Sulfate	79-95	coagulation factor II, thrombin	Homo sapiens	55-63
2529852-11	1989	The rate constant for transformation of the antithrombin III-Factor Xa complex into irreversible product differed between heparan sulphate (96 min-1) and heparin (429 min-1).	Heparitin Sulfate	122-138	serpin family C member 1	Homo sapiens	44-60
2529852-11	1989	The rate constant for transformation of the antithrombin III-Factor Xa complex into irreversible product differed between heparan sulphate (96 min-1) and heparin (429 min-1).	Heparitin Sulfate	122-138	coagulation factor X	Homo sapiens	61-70
2621717-9	1989	Heparan sulphate from small follicles bound to fibronectin (17%), laminin (15%) and that from large follicles bound to fibronectin (13%), laminin (10%) and LDL (6%).	Heparitin Sulfate	0-16	fibronectin 1	Bos taurus	47-58
2621717-9	1989	Heparan sulphate from small follicles bound to fibronectin (17%), laminin (15%) and that from large follicles bound to fibronectin (13%), laminin (10%) and LDL (6%).	Heparitin Sulfate	0-16	fibronectin 1	Bos taurus	119-130
2500452-2	1989	Binding of bFGF to ECM can be competed by heparin or heparan sulfate, and ECM-bound bFGF can be released by treating the cells with heparinase or heparatinase.	Heparitin Sulfate	53-68	fibroblast growth factor 2	Bos taurus	11-15
2500452-4	1989	The increase is prevented upon removal of ECM-bound bFGF by a neutral 2 M NaCl wash. Soluble heparin and heparan sulfate reduce the amount of ECM-bound bFGF released into the medium, possibly competing with ECM polysaccharides for heparinase-like enzymes produced by endothelial cells, suggesting that these enzymes are involved in the mobilization of ECM-bound bFGF.	Heparitin Sulfate	105-120	fibroblast growth factor 2	Bos taurus	52-56
2500452-4	1989	The increase is prevented upon removal of ECM-bound bFGF by a neutral 2 M NaCl wash. Soluble heparin and heparan sulfate reduce the amount of ECM-bound bFGF released into the medium, possibly competing with ECM polysaccharides for heparinase-like enzymes produced by endothelial cells, suggesting that these enzymes are involved in the mobilization of ECM-bound bFGF.	Heparitin Sulfate	105-120	fibroblast growth factor 2	Bos taurus	152-156
2500452-4	1989	The increase is prevented upon removal of ECM-bound bFGF by a neutral 2 M NaCl wash. Soluble heparin and heparan sulfate reduce the amount of ECM-bound bFGF released into the medium, possibly competing with ECM polysaccharides for heparinase-like enzymes produced by endothelial cells, suggesting that these enzymes are involved in the mobilization of ECM-bound bFGF.	Heparitin Sulfate	105-120	fibroblast growth factor 2	Bos taurus	152-156
2470739-9	1989	In contrast, heparan sulfate proteoglycan form LD and heparan sulfate-derivatized serum albumin had far lower inhibitory activities, indicating that the active site for the interaction between cells and PG-M is on the chondroitin sulfate chains.	Heparitin Sulfate	13-28	versican	Gallus gallus	203-207
2505639-4	1989	In addition, chondroitin sulfates and heparan sulfate are identified either by prior digestion with chondroitin ABC or AC lyase, as generated disaccharides fail to bind to the blot, or by treatment of the entire blot with nitrous acid following binding.	Heparitin Sulfate	38-53	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	112-115
2470739-9	1989	In contrast, heparan sulfate proteoglycan form LD and heparan sulfate-derivatized serum albumin had far lower inhibitory activities, indicating that the active site for the interaction between cells and PG-M is on the chondroitin sulfate chains.	Heparitin Sulfate	54-69	versican	Gallus gallus	203-207
2763268-6	1989	PF4 affinity for GAGs is as follows: heparin greater than heparan sulphate much greater than dermatan sulphate.	Heparitin Sulfate	58-74	platelet factor 4	Homo sapiens	0-3
2522961-3	1989	When the mouse glomerular basement membrane and rat Reichert"s membrane were exposed to antibodies directed to the core protein of heparan sulfate proteoglycan, 95% or more of the gold particles were over double tracks, whereas after exposure of Reichert"s membrane to antisera against laminin, collagen IV, or entactin, labeling of the double tracks remained at the random level.	Heparitin Sulfate	131-146	nidogen 1	Rattus norvegicus	311-319
2523815-4	1989	The copurification of a heparan sulfate proteoglycan with NCAM was demonstrated following immunopurification of NCAM from a detergent extract of cell membranes derived from Na2(35)SO4-labeled neural retinal cells.	Heparitin Sulfate	24-39	neural cell adhesion molecule 1	Homo sapiens	58-62
2523815-4	1989	The copurification of a heparan sulfate proteoglycan with NCAM was demonstrated following immunopurification of NCAM from a detergent extract of cell membranes derived from Na2(35)SO4-labeled neural retinal cells.	Heparitin Sulfate	24-39	neural cell adhesion molecule 1	Homo sapiens	112-116
2715188-2	1989	When HSPG isolated from confluent cells was added exogenously to log phase cells, it was internalized and free heparan sulfate (HS) chains appeared transiently in the nucleus.	Heparitin Sulfate	111-126	syndecan 2	Rattus norvegicus	5-9
2654474-9	1989	The findings are compatible with the notion that EC-SOD C in the vasculature forms an equilibrium between plasma and heparan sulfate in the glycocalyx of the endothelium.	Heparitin Sulfate	117-132	superoxide dismutase 3	Homo sapiens	49-55
2654474-10	1989	Furthermore, tissue EC-SOD is probably distributed between heparan sulfate on the surface of most cell types in the organs and in the interstitial matrix.	Heparitin Sulfate	59-74	superoxide dismutase 3	Homo sapiens	20-26
2523675-1	1989	Heparin and heparan sulfate can be cleaved selectively at their N-sulfated glucosamine residues by direct treatment with nitrous acid at pH 1.5.	Heparitin Sulfate	12-27	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	137-141
2470345-10	1989	(3) Forms I and II of liver alpha-L-iduronidase showed no difference in their activities towards disaccharide substrates derived from two glycosaminoglycan sources, heparan sulphate and dermatan sulphate.	Heparitin Sulfate	165-181	alpha-L-iduronidase	Homo sapiens	28-47
2466852-6	1989	Heparin sulfate (10 micrograms/ml) dramatically inhibited the ability of bFGF to stimulate the proliferation of keratinocytes.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	73-77
2624745-1	1989	The neural cell adhesion molecule (N-CAM) plays an integral role in cell interactions during neural development, with the binding of heparan sulfate proteoglycan to the amino-terminal region of N-CAM being required for N-CAM function.	Heparitin Sulfate	133-148	neural cell adhesion molecule 1	Rattus norvegicus	4-33
2624745-1	1989	The neural cell adhesion molecule (N-CAM) plays an integral role in cell interactions during neural development, with the binding of heparan sulfate proteoglycan to the amino-terminal region of N-CAM being required for N-CAM function.	Heparitin Sulfate	133-148	neural cell adhesion molecule 1	Rattus norvegicus	35-40
2624745-1	1989	The neural cell adhesion molecule (N-CAM) plays an integral role in cell interactions during neural development, with the binding of heparan sulfate proteoglycan to the amino-terminal region of N-CAM being required for N-CAM function.	Heparitin Sulfate	133-148	neural cell adhesion molecule 1	Rattus norvegicus	194-199
2624745-1	1989	The neural cell adhesion molecule (N-CAM) plays an integral role in cell interactions during neural development, with the binding of heparan sulfate proteoglycan to the amino-terminal region of N-CAM being required for N-CAM function.	Heparitin Sulfate	133-148	neural cell adhesion molecule 1	Rattus norvegicus	194-199
2624745-2	1989	In the present study we have used synthetic peptides (HBD-1 and HBD-2), derived from the primary amino acid sequence of rat N-CAM, to identify the region of N-CAM that binds heparan sulfate.	Heparitin Sulfate	174-189	neural cell adhesion molecule 1	Rattus norvegicus	124-129
2624745-2	1989	In the present study we have used synthetic peptides (HBD-1 and HBD-2), derived from the primary amino acid sequence of rat N-CAM, to identify the region of N-CAM that binds heparan sulfate.	Heparitin Sulfate	174-189	neural cell adhesion molecule 1	Rattus norvegicus	157-162
2521892-2	1989	Heparitinase treatment of the heparan sulfate proteoglycan fraction (containing 86% heparan sulfate and 10% chondroitin sulfate) that was eluted from the lipoprotein lipase affinity column with 1 M NaCl led to the appearance of a major protein core with a molecular size of 55,000 daltons, as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Heparitin Sulfate	30-45	lipoprotein lipase	Rattus norvegicus	154-172
2529793-3	1989	Heparitinase specifically degrades heparan sulphate, thus treatment of rat embryos with this enzyme in vitro should result in the perturbation of any tissue interactions which involve heparan sulphate proteoglycan.	Heparitin Sulfate	35-51	syndecan 2	Rattus norvegicus	184-213
2525358-2	1989	Initial studies described the significance of heparan sulfate proteoglycans of Balb/c 3T3 cells in their adhesion on fibronectin matrices, including their binding to multiple domains in FN, the importance of this binding in microfilament and close contact formation, and the cooperativity of both HS-PG and 140k glycoprotein integrin"s binding to FN to achieve tight-focal contacts under cells.	Heparitin Sulfate	46-61	fibronectin 1	Mus musculus	117-128
2735657-2	1989	We previously reported that LPL binds to cultured endothelial cells with a Km of 2.7 x 10(-7) M and that this binding is inhibited by heparinase, heparin, or heparan sulfate.	Heparitin Sulfate	158-173	lipoprotein lipase	Bos taurus	28-31
2973992-4	1988	From the estimated concentration of heparan sulphate on the endothelial cell surface it is proposed that the non-thrombogenic property of blood vessels is due to the acceleration of the factor Xa or prothrombinase:ATIII interaction by the greater mass of surface-bound heparan sulphate rather than by the much smaller proportion of heparin-like molecules (with high affinity for antithrombin III) which may be present.	Heparitin Sulfate	36-52	coagulation factor X	Homo sapiens	186-195
3223951-6	1988	However, SAA2 binding to heparan sulphate increases its beta-sheet structure, whereas with SAA1 secondary structure is not apparently altered by its interaction with heparan sulphate.	Heparitin Sulfate	25-41	serum amyloid A2	Homo sapiens	9-13
2973992-1	1988	Heparan sulphate with no affinity for antithrombin III (ATIII) was observed to cause acceleration of the factor Xa:ATIII interaction by 1100-fold (k2, 7 X 10(7) M-1.min-1) and the prothrombinase:ATIII interaction by 2900-fold (k2, 2.5 X 10(7) M-1.min-1).	Heparitin Sulfate	0-16	serpin family C member 1	Homo sapiens	56-61
2973992-4	1988	From the estimated concentration of heparan sulphate on the endothelial cell surface it is proposed that the non-thrombogenic property of blood vessels is due to the acceleration of the factor Xa or prothrombinase:ATIII interaction by the greater mass of surface-bound heparan sulphate rather than by the much smaller proportion of heparin-like molecules (with high affinity for antithrombin III) which may be present.	Heparitin Sulfate	36-52	coagulation factor X	Homo sapiens	199-213
2973992-1	1988	Heparan sulphate with no affinity for antithrombin III (ATIII) was observed to cause acceleration of the factor Xa:ATIII interaction by 1100-fold (k2, 7 X 10(7) M-1.min-1) and the prothrombinase:ATIII interaction by 2900-fold (k2, 2.5 X 10(7) M-1.min-1).	Heparitin Sulfate	0-16	coagulation factor X	Homo sapiens	105-114
2973992-4	1988	From the estimated concentration of heparan sulphate on the endothelial cell surface it is proposed that the non-thrombogenic property of blood vessels is due to the acceleration of the factor Xa or prothrombinase:ATIII interaction by the greater mass of surface-bound heparan sulphate rather than by the much smaller proportion of heparin-like molecules (with high affinity for antithrombin III) which may be present.	Heparitin Sulfate	36-52	serpin family C member 1	Homo sapiens	214-219
2973992-1	1988	Heparan sulphate with no affinity for antithrombin III (ATIII) was observed to cause acceleration of the factor Xa:ATIII interaction by 1100-fold (k2, 7 X 10(7) M-1.min-1) and the prothrombinase:ATIII interaction by 2900-fold (k2, 2.5 X 10(7) M-1.min-1).	Heparitin Sulfate	0-16	serpin family C member 1	Homo sapiens	115-120
2973992-1	1988	Heparan sulphate with no affinity for antithrombin III (ATIII) was observed to cause acceleration of the factor Xa:ATIII interaction by 1100-fold (k2, 7 X 10(7) M-1.min-1) and the prothrombinase:ATIII interaction by 2900-fold (k2, 2.5 X 10(7) M-1.min-1).	Heparitin Sulfate	0-16	coagulation factor X	Homo sapiens	180-194
2973992-4	1988	From the estimated concentration of heparan sulphate on the endothelial cell surface it is proposed that the non-thrombogenic property of blood vessels is due to the acceleration of the factor Xa or prothrombinase:ATIII interaction by the greater mass of surface-bound heparan sulphate rather than by the much smaller proportion of heparin-like molecules (with high affinity for antithrombin III) which may be present.	Heparitin Sulfate	36-52	serpin family C member 1	Homo sapiens	379-395
2973992-1	1988	Heparan sulphate with no affinity for antithrombin III (ATIII) was observed to cause acceleration of the factor Xa:ATIII interaction by 1100-fold (k2, 7 X 10(7) M-1.min-1) and the prothrombinase:ATIII interaction by 2900-fold (k2, 2.5 X 10(7) M-1.min-1).	Heparitin Sulfate	0-16	serpin family C member 1	Homo sapiens	115-120
2973992-4	1988	From the estimated concentration of heparan sulphate on the endothelial cell surface it is proposed that the non-thrombogenic property of blood vessels is due to the acceleration of the factor Xa or prothrombinase:ATIII interaction by the greater mass of surface-bound heparan sulphate rather than by the much smaller proportion of heparin-like molecules (with high affinity for antithrombin III) which may be present.	Heparitin Sulfate	269-285	coagulation factor X	Homo sapiens	186-195
2973992-4	1988	From the estimated concentration of heparan sulphate on the endothelial cell surface it is proposed that the non-thrombogenic property of blood vessels is due to the acceleration of the factor Xa or prothrombinase:ATIII interaction by the greater mass of surface-bound heparan sulphate rather than by the much smaller proportion of heparin-like molecules (with high affinity for antithrombin III) which may be present.	Heparitin Sulfate	269-285	coagulation factor X	Homo sapiens	199-213
2973992-4	1988	From the estimated concentration of heparan sulphate on the endothelial cell surface it is proposed that the non-thrombogenic property of blood vessels is due to the acceleration of the factor Xa or prothrombinase:ATIII interaction by the greater mass of surface-bound heparan sulphate rather than by the much smaller proportion of heparin-like molecules (with high affinity for antithrombin III) which may be present.	Heparitin Sulfate	269-285	serpin family C member 1	Homo sapiens	214-219
3144000-3	1988	One such molecule is a cell surface proteoglycan, named syndecan, that contains both heparan sulfate and chondroitin sulfate chains.	Heparitin Sulfate	85-100	syndecan 1	Homo sapiens	56-64
2971068-0	1988	Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.	Heparitin Sulfate	25-40	fibroblast growth factor 2	Bos taurus	47-77
2973466-5	1988	In contrast, acidic fibroblast growth factor (aFGF) displayed negligible binding to heparan sulfate proteoglycan.	Heparitin Sulfate	84-99	fibroblast growth factor 1	Homo sapiens	13-44
2973466-5	1988	In contrast, acidic fibroblast growth factor (aFGF) displayed negligible binding to heparan sulfate proteoglycan.	Heparitin Sulfate	84-99	fibroblast growth factor 1	Homo sapiens	46-50
2970980-1	1988	In this study we examined the effect of experimental diabetes and of treatment with an aldose reductase inhibitor on the level of sulfation of glomerular basement membrane (GBM) heparan sulfate, the principal glycosaminoglycan in this extracellular matrix.	Heparitin Sulfate	178-193	aldo-keto reductase family 1 member B1	Rattus norvegicus	87-103
2973155-1	1988	Recent evidence suggests that heparan sulfate on endothelial cell surfaces acts as a catalyst for the neutralization of thrombin by antithrombin III (AT III).	Heparitin Sulfate	30-45	serpin family C member 1	Homo sapiens	150-156
2973155-3	1988	We evaluated the ability of cultured human fibroblasts to catalyze the interaction between thrombin and AT III and found that heparan sulfate produced by post-confluent fibroblasts was anticoagulantly active.	Heparitin Sulfate	126-141	coagulation factor II, thrombin	Homo sapiens	91-99
2973155-3	1988	We evaluated the ability of cultured human fibroblasts to catalyze the interaction between thrombin and AT III and found that heparan sulfate produced by post-confluent fibroblasts was anticoagulantly active.	Heparitin Sulfate	126-141	serpin family C member 1	Homo sapiens	104-110
2973155-5	1988	These results indicate that fibroblasts do produce an anticoagulantly active species of heparan sulfate and that the normal interaction between AT III and thrombin may be driven by initial release of heparan sulfate from the cell surface by thrombin followed by AT III interaction with the soluble thrombin-heparan sulfate complex.	Heparitin Sulfate	200-215	serpin family C member 1	Homo sapiens	144-150
2973155-5	1988	These results indicate that fibroblasts do produce an anticoagulantly active species of heparan sulfate and that the normal interaction between AT III and thrombin may be driven by initial release of heparan sulfate from the cell surface by thrombin followed by AT III interaction with the soluble thrombin-heparan sulfate complex.	Heparitin Sulfate	200-215	coagulation factor II, thrombin	Homo sapiens	155-163
2973155-5	1988	These results indicate that fibroblasts do produce an anticoagulantly active species of heparan sulfate and that the normal interaction between AT III and thrombin may be driven by initial release of heparan sulfate from the cell surface by thrombin followed by AT III interaction with the soluble thrombin-heparan sulfate complex.	Heparitin Sulfate	200-215	coagulation factor II, thrombin	Homo sapiens	241-249
2973155-5	1988	These results indicate that fibroblasts do produce an anticoagulantly active species of heparan sulfate and that the normal interaction between AT III and thrombin may be driven by initial release of heparan sulfate from the cell surface by thrombin followed by AT III interaction with the soluble thrombin-heparan sulfate complex.	Heparitin Sulfate	200-215	coagulation factor II, thrombin	Homo sapiens	241-249
2973155-5	1988	These results indicate that fibroblasts do produce an anticoagulantly active species of heparan sulfate and that the normal interaction between AT III and thrombin may be driven by initial release of heparan sulfate from the cell surface by thrombin followed by AT III interaction with the soluble thrombin-heparan sulfate complex.	Heparitin Sulfate	200-215	serpin family C member 1	Homo sapiens	144-150
2973155-5	1988	These results indicate that fibroblasts do produce an anticoagulantly active species of heparan sulfate and that the normal interaction between AT III and thrombin may be driven by initial release of heparan sulfate from the cell surface by thrombin followed by AT III interaction with the soluble thrombin-heparan sulfate complex.	Heparitin Sulfate	200-215	coagulation factor II, thrombin	Homo sapiens	155-163
2973155-5	1988	These results indicate that fibroblasts do produce an anticoagulantly active species of heparan sulfate and that the normal interaction between AT III and thrombin may be driven by initial release of heparan sulfate from the cell surface by thrombin followed by AT III interaction with the soluble thrombin-heparan sulfate complex.	Heparitin Sulfate	200-215	coagulation factor II, thrombin	Homo sapiens	241-249
2973155-5	1988	These results indicate that fibroblasts do produce an anticoagulantly active species of heparan sulfate and that the normal interaction between AT III and thrombin may be driven by initial release of heparan sulfate from the cell surface by thrombin followed by AT III interaction with the soluble thrombin-heparan sulfate complex.	Heparitin Sulfate	200-215	coagulation factor II, thrombin	Homo sapiens	241-249
2973155-1	1988	Recent evidence suggests that heparan sulfate on endothelial cell surfaces acts as a catalyst for the neutralization of thrombin by antithrombin III (AT III).	Heparitin Sulfate	30-45	coagulation factor II, thrombin	Homo sapiens	120-128
2973155-1	1988	Recent evidence suggests that heparan sulfate on endothelial cell surfaces acts as a catalyst for the neutralization of thrombin by antithrombin III (AT III).	Heparitin Sulfate	30-45	serpin family C member 1	Homo sapiens	132-148
2968652-0	1988	Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein.	Heparitin Sulfate	45-60	amyloid beta precursor protein	Homo sapiens	0-12
2968652-2	1988	It is now shown that the core protein of a heparan sulfate proteoglycan secreted from a nerve cell line (PC12) has an amino acid sequence and a size very similar to those of the amyloid beta protein precursor and that these molecules are antigenically related.	Heparitin Sulfate	43-58	amyloid beta precursor protein	Homo sapiens	178-190
2968652-3	1988	This amyloid beta protein precursor-related protein is not found in the conditioned medium of a variant cell line (F3 PC12) that does not secrete heparan sulfate proteoglycan.	Heparitin Sulfate	146-161	amyloid beta precursor protein	Homo sapiens	5-17
2971068-1	1988	Cultured bovine capillary endothelial (BCE) cells were found to synthesize and secrete high molecular mass heparan sulfate proteoglycans and glycosaminoglycans, which bound basic fibroblast growth factor (bFGF).	Heparitin Sulfate	107-122	fibroblast growth factor 2	Bos taurus	173-203
2971068-1	1988	Cultured bovine capillary endothelial (BCE) cells were found to synthesize and secrete high molecular mass heparan sulfate proteoglycans and glycosaminoglycans, which bound basic fibroblast growth factor (bFGF).	Heparitin Sulfate	107-122	fibroblast growth factor 2	Bos taurus	205-209
2971068-2	1988	The secreted heparan sulfate molecules were purified by DEAE cellulose chromatography, followed by Sepharose 4B chromatography and affinity chromatography on immobilized bFGF.	Heparitin Sulfate	13-28	fibroblast growth factor 2	Bos taurus	170-174
2971068-4	1988	However, elution from bFGF with increasing salt concentrations demonstrated varying affinities for bFGF among the secreted heparan sulfate molecules, with part of the heparan sulfate requiring NaCl concentrations between 1.0 and 1.5 M for elution.	Heparitin Sulfate	123-138	fibroblast growth factor 2	Bos taurus	22-26
2971068-4	1988	However, elution from bFGF with increasing salt concentrations demonstrated varying affinities for bFGF among the secreted heparan sulfate molecules, with part of the heparan sulfate requiring NaCl concentrations between 1.0 and 1.5 M for elution.	Heparitin Sulfate	123-138	fibroblast growth factor 2	Bos taurus	99-103
2971068-6	1988	The purified bFGF-binding heparan sulfate competed with 125I-bFGF for binding to low-affinity binding sites but not to high-affinity sites on the cells.	Heparitin Sulfate	26-41	fibroblast growth factor 2	Bos taurus	13-17
2971068-6	1988	The purified bFGF-binding heparan sulfate competed with 125I-bFGF for binding to low-affinity binding sites but not to high-affinity sites on the cells.	Heparitin Sulfate	26-41	fibroblast growth factor 2	Bos taurus	61-65
2971068-8	1988	Soluble bFGF was readily degraded by plasmin, whereas bFGF bound to heparan sulfate was protected from proteolytic degradation.	Heparitin Sulfate	68-83	fibroblast growth factor 2	Bos taurus	54-58
2971068-9	1988	Treatment of the heparan sulfate with heparinase before addition of plasmin abolished the protection and resulted in degradation of bFGF by the added proteinase.	Heparitin Sulfate	17-32	fibroblast growth factor 2	Bos taurus	132-136
2971068-10	1988	The results suggest that heparan sulfate released either directly by cells or through proteolytic degradation of their extracellular milieu may act as carrier for bFGF and facilitate the diffusion of locally produced growth factor by competing with its binding to surrounding matrix structures.	Heparitin Sulfate	25-40	fibroblast growth factor 2	Bos taurus	163-167
2965305-6	1988	Here, we clearly demonstrate that the major sulphated glycosaminoglycan of mouse marrow stroma, heparan sulphate, possesses the ability to adsorb both GM-CSF and the multilineage haemopoietic growth factor, Interleukin 3 (IL-3).	Heparitin Sulfate	96-112	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	151-157
3260902-6	1988	However, a highly inhibitory heparan sulfate species obtained from postconfluent SMC suppressed EGF binding by 45%.	Heparitin Sulfate	29-44	LOC521832	Bos taurus	96-99
2897367-2	1988	Here we report that the 250-kDa receptor subunit that binds the multifunctional protein, transforming growth factor-beta 1 (TGF-beta 1), contains chains of heparan sulfate and chondroitin sulfate and thus is a proteoglycan.	Heparitin Sulfate	156-171	transforming growth factor beta 1	Homo sapiens	89-122
2897367-2	1988	Here we report that the 250-kDa receptor subunit that binds the multifunctional protein, transforming growth factor-beta 1 (TGF-beta 1), contains chains of heparan sulfate and chondroitin sulfate and thus is a proteoglycan.	Heparitin Sulfate	156-171	transforming growth factor beta 1	Homo sapiens	124-134
2967181-4	1988	P-HS 1 has a Mr of 175,000 and possesses four heparan sulfate side-chains (Mr 32,000) covalently bound to the protein core via a galactose- and xylose-containing polysaccharide-protein binding region.	Heparitin Sulfate	46-61	prostaglandin-endoperoxide synthase 1	Bos taurus	0-6
3280364-11	1988	The medium and the Triton extract contained different proportions of both chondroitin sulfate and heparan sulfate proteoglycans, while heparan sulfate was the only proteoglycan recovered from the guanidine extract.	Heparitin Sulfate	98-113	versican	Gallus gallus	114-126
3391615-1	1988	Glucosamine-6-sulphatase (G6S), a lysosomal enzyme found in all cells, is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate.	Heparitin Sulfate	113-129	glucosamine (N-acetyl)-6-sulfatase	Homo sapiens	0-24
3391615-1	1988	Glucosamine-6-sulphatase (G6S), a lysosomal enzyme found in all cells, is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate.	Heparitin Sulfate	113-129	glucosamine (N-acetyl)-6-sulfatase	Homo sapiens	26-29
2967301-0	1988	Heparan sulfate proteoglycans in the substratum adhesion sites of human neuroblastoma cells: modulation of affinity binding to fibronectin.	Heparitin Sulfate	0-15	fibronectin 1	Homo sapiens	127-138
2967302-8	1988	Increasing concentrations of heparan sulfate, dermatan sulfate, and chondroitin sulfate correlated with increasing aFGF potentiation.	Heparitin Sulfate	29-44	fibroblast growth factor 1	Rattus norvegicus	115-119
2967302-9	1988	The maximally active concentrations of heparan sulfate (100 micrograms/ml), dermatan sulfate (10 mg/ml), and chondroitin sulfate (1 mg/ml) increased the activity of aFGF 11-, 110-, and 11-fold, respectively.	Heparitin Sulfate	39-54	fibroblast growth factor 1	Rattus norvegicus	165-169
2967302-15	1988	The highest concentration of heparan sulfate studied (1 mg/ml) inhibited the activity of bFGF.	Heparitin Sulfate	29-44	fibroblast growth factor 2	Rattus norvegicus	89-93
2967302-17	1988	Heparan sulfate and chondroitin sulfate showed concentration-dependent potentiation of NGF; maximally active concentrations of heparan sulfate (100 micrograms/ml) and chondroitin sulfate (1 mg/ml) increased the potency of NGF 3-fold, whereas heparin, dermatan sulfate and hyaluronic acid had no effect.	Heparitin Sulfate	0-15	nerve growth factor	Rattus norvegicus	87-90
2967302-17	1988	Heparan sulfate and chondroitin sulfate showed concentration-dependent potentiation of NGF; maximally active concentrations of heparan sulfate (100 micrograms/ml) and chondroitin sulfate (1 mg/ml) increased the potency of NGF 3-fold, whereas heparin, dermatan sulfate and hyaluronic acid had no effect.	Heparitin Sulfate	0-15	nerve growth factor	Rattus norvegicus	222-225
2967302-17	1988	Heparan sulfate and chondroitin sulfate showed concentration-dependent potentiation of NGF; maximally active concentrations of heparan sulfate (100 micrograms/ml) and chondroitin sulfate (1 mg/ml) increased the potency of NGF 3-fold, whereas heparin, dermatan sulfate and hyaluronic acid had no effect.	Heparitin Sulfate	127-142	nerve growth factor	Rattus norvegicus	87-90
2967302-17	1988	Heparan sulfate and chondroitin sulfate showed concentration-dependent potentiation of NGF; maximally active concentrations of heparan sulfate (100 micrograms/ml) and chondroitin sulfate (1 mg/ml) increased the potency of NGF 3-fold, whereas heparin, dermatan sulfate and hyaluronic acid had no effect.	Heparitin Sulfate	127-142	nerve growth factor	Rattus norvegicus	222-225
2965305-6	1988	Here, we clearly demonstrate that the major sulphated glycosaminoglycan of mouse marrow stroma, heparan sulphate, possesses the ability to adsorb both GM-CSF and the multilineage haemopoietic growth factor, Interleukin 3 (IL-3).	Heparitin Sulfate	96-112	interleukin 3	Mus musculus	207-220
2965305-6	1988	Here, we clearly demonstrate that the major sulphated glycosaminoglycan of mouse marrow stroma, heparan sulphate, possesses the ability to adsorb both GM-CSF and the multilineage haemopoietic growth factor, Interleukin 3 (IL-3).	Heparitin Sulfate	96-112	interleukin 3	Mus musculus	222-226
2906331-9	1988	The mitogenic activities of aFGF and bFGF were potentiated similarly by heparan sulfate and by heparin, with a maximum stimulation of about 100% at 100 micrograms/ml heparin.	Heparitin Sulfate	72-87	fibroblast growth factor 1	Rattus norvegicus	28-32
2964821-0	1988	Isolation of heparan sulfates with antithrombin III affinity and anticoagulant potency from BALB/c 3T3, B16.F10 melanoma, and cutaneous fibrosarcoma cell lines.	Heparitin Sulfate	13-29	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	35-51
3276308-3	1988	A specific binding of SAP to hyaluronic acid, heparan sulfate, and dermatan sulfate was also confirmed by the fact that these glycosaminoglycans blocked the binding of SAP to agarose, a specific ligand of SAP.	Heparitin Sulfate	46-61	amyloid P component, serum	Homo sapiens	22-25
3401619-7	1988	Heparan sulfate chains were isolated as chondroitinase-resistant material and treated with nitrous acid.	Heparitin Sulfate	0-15	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	40-54
2963012-9	1988	These results indicate that the mammary epithelial cells have at least two distinct cell surface receptors for fibronectin: a trypsin-resistant molecule that binds cells to the sequence RGD and a trypsin-labile, heparan sulfate-rich PG that binds cells to the COOH-terminal heparin binding domain.	Heparitin Sulfate	212-227	fibronectin 1	Mus musculus	111-122
2906331-9	1988	The mitogenic activities of aFGF and bFGF were potentiated similarly by heparan sulfate and by heparin, with a maximum stimulation of about 100% at 100 micrograms/ml heparin.	Heparitin Sulfate	72-87	fibroblast growth factor 2	Rattus norvegicus	37-41
3374475-4	1988	LPL secretion could also be stimulated by heparan sulfate and dermatan sulfate, but not by hyaluronic acid, chondroitin sulfate or keratan sulfate.	Heparitin Sulfate	42-57	lipoprotein lipase	Rattus norvegicus	0-3
3680513-6	1987	We therefore conclude that the effect of warfarin on hemostatic system activation is modulated by the endogenous heparan sulfate-antithrombin mechanism.	Heparitin Sulfate	113-128	serpin family C member 1	Homo sapiens	129-141
2445746-9	1987	Like platelet factor 4, but unlike histidine-rich glycoprotein, S protein/vitronectin readily neutralized the anticoagulant activities of heparan sulfate of Mr approximately 20,000.	Heparitin Sulfate	138-153	vitronectin	Homo sapiens	64-73
2445746-9	1987	Like platelet factor 4, but unlike histidine-rich glycoprotein, S protein/vitronectin readily neutralized the anticoagulant activities of heparan sulfate of Mr approximately 20,000.	Heparitin Sulfate	138-153	vitronectin	Homo sapiens	74-85
2445746-10	1987	These findings suggest that S protein/vitronectin may interact through its glycosaminoglycan binding domain(s) with various functional domains of the heparin (heparan sulfate) molecule, including the antithrombin-binding pentasaccharide sequence.	Heparitin Sulfate	159-174	vitronectin	Homo sapiens	28-37
2445746-10	1987	These findings suggest that S protein/vitronectin may interact through its glycosaminoglycan binding domain(s) with various functional domains of the heparin (heparan sulfate) molecule, including the antithrombin-binding pentasaccharide sequence.	Heparitin Sulfate	159-174	vitronectin	Homo sapiens	38-49
2445746-10	1987	These findings suggest that S protein/vitronectin may interact through its glycosaminoglycan binding domain(s) with various functional domains of the heparin (heparan sulfate) molecule, including the antithrombin-binding pentasaccharide sequence.	Heparitin Sulfate	159-174	serpin family C member 1	Homo sapiens	200-212
3123254-7	1987	The action of protamine on PF4 kinetics in the rabbits pretreated with 30 mg heparan sulphate was similar to that obtained with heparin pretreatment; however, a higher dose of protamine was required to obtain the optimal effect.	Heparitin Sulfate	77-93	platelet factor 4	Homo sapiens	27-30
2446864-7	1987	Binding of MAG to collagen G is most effectively blocked by a high molecular weight dextran sulfate, heparan sulfate and heparin, with chondroitin sulfate and a low molecular weight dextran sulfate being less potent blockers.	Heparitin Sulfate	101-116	myelin-associated glycoprotein	Mus musculus	11-14
2963617-0	1987	Basement-membrane heparan sulphate with high affinity for antithrombin synthesized by normal and transformed mouse mammary epithelial cells.	Heparitin Sulfate	18-34	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	58-70
3689206-4	1987	This binding was displaced by heparin and was completely abolished by selective removal of heparan sulfate from cells with heparitinase, indicating that antithrombin III binds to heparan sulfate on the surface of endothelial cells.	Heparitin Sulfate	91-106	serpin family C member 1	Homo sapiens	153-169
3689206-4	1987	This binding was displaced by heparin and was completely abolished by selective removal of heparan sulfate from cells with heparitinase, indicating that antithrombin III binds to heparan sulfate on the surface of endothelial cells.	Heparitin Sulfate	179-194	serpin family C member 1	Homo sapiens	153-169
3689206-8	1987	Whereas the size of heparan sulfate chains derived from the cell surface was not altered by xyloside treatment, they appeared to have slightly less net negative charge and a significantly reduced proportion of the molecule with high affinity for antithrombin III in the presence of xyloside.	Heparitin Sulfate	20-35	serpin family C member 1	Homo sapiens	246-262
3689206-11	1987	These results suggest that beta-D-xyloside caused a dose-dependent decrease in production as well as some subtle structural alterations of cell-surface-associated heparan sulfate, which could serve as binding sites for antithrombin III on the endothelial cells and mediate enhancing the anticoagulant activity of this protein.	Heparitin Sulfate	163-178	serpin family C member 1	Homo sapiens	219-235
3680389-6	1987	The second, a relatively smaller proteoglycan, eluted from Sepharose CL-2B with a Kav of 0.61 and contained primarily heparan sulfate chains with an average molecular weight of 16,000.	Heparitin Sulfate	118-133	versican	Gallus gallus	33-45
3680389-9	1987	A second, smaller proteoglycan had a similar monomer size (Kav of 0.63) to the cell layer heparan sulfate proteoglycan, but differed from it in that this molecule contained primarily chondroitin sulfate chains with an average molecular weight of 32,000.	Heparitin Sulfate	90-105	versican	Gallus gallus	18-30
2958303-2	1987	The promotion of normal cell growth by aFGF was suppressed by heparan sulfate but enhanced by heparin, while growth promotion by bFGF was suppressed by both GAGs.	Heparitin Sulfate	62-77	fibroblast growth factor 1	Homo sapiens	39-43
2958303-4	1987	The growth of spontaneously transformed cells was enhanced by heparan sulfate or heparin in the presence of 10% FBS or aFGF, while growth promotion in the presence of bFGF was suppressed by both GAGs.	Heparitin Sulfate	62-77	fibroblast growth factor 1	Homo sapiens	119-123
2958303-6	1987	The findings that heparan sulfate enhanced the growth of transformed cells but suppressed the growth of normal cells in the presence of 10% FBS or aFGF were consistent with those of our previous studies on human fibroblasts, confirming the occurrence of some common alterations in the signal transduction system or cell surface upon cellular transformation.	Heparitin Sulfate	18-33	fibroblast growth factor 1	Homo sapiens	147-151
2957958-0	1987	Effects of nerve growth factor-induced differentiation on the heparan sulfate of PC12 pheochromocytoma cells and comparison with developing brain.	Heparitin Sulfate	62-77	nerve growth factor	Rattus norvegicus	11-30
3476950-9	1987	This sequence probably confers the affinity of EC-SOD for heparin and heparan sulfate.	Heparitin Sulfate	70-85	superoxide dismutase 3	Homo sapiens	47-53
2957958-2	1987	Nitrous acid degradation studies revealed significant differences in the distribution of N-sulfate and N-acetyl groups in heparan sulfate present in the PC12 cell-soluble fraction, membranes, and medium and demonstrated that NGF treatment led to an increased proportion of N-sulfated segments in the cell-associated heparan sulfate, although no such change was seen in that released into the culture medium.	Heparitin Sulfate	122-137	nerve growth factor	Rattus norvegicus	225-228
3574136-3	1987	Since the glycosaminoglycan, heparan sulfate, was found to stimulate the lipoprotein lipase reaction in vitro, we investigated the plasma heparan sulfate content and measured the urinary excretion of heparan sulfate in control rats and rats with experimentally induced nephrotic syndrome.	Heparitin Sulfate	29-44	lipoprotein lipase	Rattus norvegicus	73-91
2957958-2	1987	Nitrous acid degradation studies revealed significant differences in the distribution of N-sulfate and N-acetyl groups in heparan sulfate present in the PC12 cell-soluble fraction, membranes, and medium and demonstrated that NGF treatment led to an increased proportion of N-sulfated segments in the cell-associated heparan sulfate, although no such change was seen in that released into the culture medium.	Heparitin Sulfate	316-331	nerve growth factor	Rattus norvegicus	225-228
2957958-6	1987	Our studies therefore demonstrate the presence in PC12 cells of several pools of heparan sulfate having different structural properties, and that significant alterations in the charge, size, and sulfation pattern of PC12 cell heparan sulfate accompany NGF-induced differentiation and neurite outgrowth.	Heparitin Sulfate	81-96	nerve growth factor	Rattus norvegicus	252-255
2957958-6	1987	Our studies therefore demonstrate the presence in PC12 cells of several pools of heparan sulfate having different structural properties, and that significant alterations in the charge, size, and sulfation pattern of PC12 cell heparan sulfate accompany NGF-induced differentiation and neurite outgrowth.	Heparitin Sulfate	226-241	nerve growth factor	Rattus norvegicus	252-255
2954956-0	1987	Isolation and characterization of fibronectin-binding proteoglycan carrying both heparan sulfate and dermatan sulfate chains from human placenta.	Heparitin Sulfate	81-96	fibronectin 1	Homo sapiens	34-45
2955807-0	1987	Comparative effect of heparin and heparan sulphate on two abnormal antithrombin III type 3 variants.	Heparitin Sulfate	34-50	serpin family C member 1	Homo sapiens	67-83
2955807-4	1987	In an attempt to explain the thrombotic tendency observed in this abnormality we compared the effect of heparin and heparan sulphate on these abnormal AT III, since, unlike heparin, heparan sulphate is a naturally occurring anticoagulant in the human.	Heparitin Sulfate	116-132	serpin family C member 1	Homo sapiens	151-157
2955807-7	1987	At this concentration of heparan sulphate the two abnormal AT III still exhibit a heparin cofactor activity below 10%.	Heparitin Sulfate	25-41	serpin family C member 1	Homo sapiens	59-65
2955079-9	1987	The large-sized HSPG, which is concentrated in synaptic regions, contains only GAG chains of Mr 20,000, suggesting that each HSPG contains only one kind of heparan sulfate chain in its structure.	Heparitin Sulfate	156-171	syndecan 2	Rattus norvegicus	16-20
2955079-9	1987	The large-sized HSPG, which is concentrated in synaptic regions, contains only GAG chains of Mr 20,000, suggesting that each HSPG contains only one kind of heparan sulfate chain in its structure.	Heparitin Sulfate	156-171	syndecan 2	Rattus norvegicus	125-129
2440029-5	1987	Competition experiments using heparin, heparan sulfate, and other sulfated polysaccharides show that this fibronectin site interacts with heparin-like cell or particle surface components in promoting matrix-driven translocation.	Heparitin Sulfate	39-54	fibronectin 1	Homo sapiens	106-117
3032267-11	1987	The accumulated heparan sulfate could then promote a sustained release of lipoprotein lipase into the culture medium which in turn leads to increased enzyme synthesis.	Heparitin Sulfate	16-31	lipoprotein lipase	Rattus norvegicus	74-92
2951375-0	1987	Structure and affinity for antithrombin of heparan sulfate chains derived from basement membrane proteoglycans.	Heparitin Sulfate	43-58	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	27-39
2948956-0	1987	Ca2+-mediated association of human serum amyloid P component with heparan sulfate and dermatan sulfate.	Heparitin Sulfate	66-81	amyloid P component, serum	Homo sapiens	35-60
2948956-2	1987	The binding of human SAP to heparan sulfate and dermatan sulfate was studied using Sepharose-immobilized SAP.	Heparitin Sulfate	28-43	amyloid P component, serum	Homo sapiens	21-24
2948956-3	1987	The apparent dissociation constants of heparan sulfate and dermatan sulfate for immobilized-SAP were estimated to be approximately 2 X 10(-7) M in the presence of 2 mM CaCl2 at neutral pH and physiological ionic strength.	Heparitin Sulfate	39-54	amyloid P component, serum	Homo sapiens	92-95
2948956-7	1987	The calcium-dependent binding of [3H]heparan sulfate and [3H]dermatan sulfate to SAP was strongly inhibited by heparan sulfate, heparin, and dermatan sulfate.	Heparitin Sulfate	37-52	amyloid P component, serum	Homo sapiens	81-84
2948961-7	1987	Initially (Step 1) there was proteolytic cleavage of the protein core and partial endoglycosidic cleavage of the heparan sulfate chains (t1/2 approximately 6 h), with generation of larger glycosaminoglycan-peptide intermediates with chains of Mr approximately 10,000, about one-third their original size.	Heparitin Sulfate	113-128	interleukin 1 receptor like 1	Homo sapiens	137-159
3793724-1	1987	Inhibition of thrombin by heparin cofactor II (HCII) is accelerated by dermatan sulfate, heparan sulfate, and heparin.	Heparitin Sulfate	89-104	coagulation factor II, thrombin	Homo sapiens	14-22
3793724-1	1987	Inhibition of thrombin by heparin cofactor II (HCII) is accelerated by dermatan sulfate, heparan sulfate, and heparin.	Heparitin Sulfate	89-104	serpin family D member 1	Homo sapiens	26-45
3793724-1	1987	Inhibition of thrombin by heparin cofactor II (HCII) is accelerated by dermatan sulfate, heparan sulfate, and heparin.	Heparitin Sulfate	89-104	serpin family D member 1	Homo sapiens	47-51
3118854-9	1987	Though the percentage of heparan sulfate on total glycosaminoglycans (GAGs) of the C-6-S group was lower than in the cholesterol-diet group, there were no significant differences in the percentages of dermatan sulfate and chondroitin-4/6-sulfate in total GAGs between the cholesterol-diet and C-6-S groups.	Heparitin Sulfate	25-40	LOW QUALITY PROTEIN: complement component C6	Oryctolagus cuniculus	83-86
3545309-7	1986	Since 100 percent of the cells examined showed positive and specific immunofluorescent staining with well-characterized antibodies to the four components of the extracellular matrix, and since studies with colloidal gold revealed the presence of fibronectin closely associated with and inside cells identified by electron microscopy as Sertoli cells, it must be concluded that Sertoli cells synthesize these four proteins and presumably heparan sulfate.	Heparitin Sulfate	437-452	fibronectin 1	Rattus norvegicus	246-257
3766958-1	1986	We found a tumor metastasis-associated heparan sulfate (HS)-degrading endoglycosidase in melanoma cells that is a unique endo-beta-glucuronidase (heparanase) capable of specifically cleaving HS at intrachain sites (M. Nakajima, T. Irimura, N. DiFerrante, and G. L. Nicolson, 1984, J. Biol.	Heparitin Sulfate	39-54	glucuronidase, beta	Mus musculus	126-144
2947695-4	1986	Distribution of fibronectin differed from that of laminin and correlated best with that of heparan sulfate proteoglycan.	Heparitin Sulfate	91-106	fibronectin 1	Homo sapiens	16-27
3768351-0	1986	Chemically modified heparins as inhibitors of heparan sulfate specific endo-beta-glucuronidase (heparanase) of metastatic melanoma cells.	Heparitin Sulfate	46-61	glucuronidase, beta	Mus musculus	76-94
3768351-1	1986	To determine the significance of the heparan sulfate (HS) degradative endo-beta-glucuronidase (heparanase) in tumor invasion and metastasis and to develop possible antimetastatic agents, we synthesized specific inhibitors of this enzyme.	Heparitin Sulfate	37-52	glucuronidase, beta	Mus musculus	75-93
3768351-1	1986	To determine the significance of the heparan sulfate (HS) degradative endo-beta-glucuronidase (heparanase) in tumor invasion and metastasis and to develop possible antimetastatic agents, we synthesized specific inhibitors of this enzyme.	Heparitin Sulfate	54-56	glucuronidase, beta	Mus musculus	75-93
3766958-1	1986	We found a tumor metastasis-associated heparan sulfate (HS)-degrading endoglycosidase in melanoma cells that is a unique endo-beta-glucuronidase (heparanase) capable of specifically cleaving HS at intrachain sites (M. Nakajima, T. Irimura, N. DiFerrante, and G. L. Nicolson, 1984, J. Biol.	Heparitin Sulfate	56-58	glucuronidase, beta	Mus musculus	126-144
3766958-1	1986	We found a tumor metastasis-associated heparan sulfate (HS)-degrading endoglycosidase in melanoma cells that is a unique endo-beta-glucuronidase (heparanase) capable of specifically cleaving HS at intrachain sites (M. Nakajima, T. Irimura, N. DiFerrante, and G. L. Nicolson, 1984, J. Biol.	Heparitin Sulfate	191-193	glucuronidase, beta	Mus musculus	126-144
3766958-8	1986	Incubation of the solid-phase HS substrates with B16 melanoma cell extracts in the presence of D-saccharic acid 1,4-lactone (a potent exo-beta-glucuronidase inhibitor) resulted in the time- and dose-dependent release of [14C]HS fragments.	Heparitin Sulfate	30-32	glucuronidase, beta	Mus musculus	138-156
3768885-2	1986	Both TA3-Ha and TA3-St cells contained cell-surface heparan sulfate that was released into culture, but not chondroitin sulfate.	Heparitin Sulfate	52-67	RIKEN cDNA 2700049A03 gene	Mus musculus	5-8
3768885-2	1986	Both TA3-Ha and TA3-St cells contained cell-surface heparan sulfate that was released into culture, but not chondroitin sulfate.	Heparitin Sulfate	52-67	RIKEN cDNA 2700049A03 gene	Mus musculus	16-19
3754874-3	1986	Purpurin is a constituent of adherons and promotes cell-adheron adhesion by interacting with a cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	108-123	retinol binding protein 4	Gallus gallus	0-8
3731061-2	1986	The optimum pH for HS degradation by HS endoglycosidase (heparanase) for all cell lines is about 5.6, but the activity of the enzyme is still present at physiological pH.	Heparitin Sulfate	19-21	heparanase	Mus musculus	57-67
3731061-3	1986	The gel permeation analysis of degradation products revealed that heparanase cuts HS in fragments about one-seventh of their original size.	Heparitin Sulfate	82-84	heparanase	Mus musculus	66-76
2943303-8	1986	35SO4(2-)-Labeled heparan sulfate chains prepared from the proteoglycan by a beta-elimination reaction were endocytosed with similar kinetics.	Heparitin Sulfate	18-33	amyloid beta precursor protein	Homo sapiens	75-81
2937928-1	1986	We have previously communicated that heparan sulfate and heparin released 16S acetylcholinesterase (AChE) from cholinergic synapses.	Heparitin Sulfate	37-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	100-104
2418031-6	1986	A 25,000-mol-wt heparin (heparan sulfate)-binding domain of N-CAM has been identified by limited proteolysis, and this fragment promotes cell attachment when bound to glass surfaces.	Heparitin Sulfate	25-40	neural cell adhesion molecule 1	Gallus gallus	60-65
2418031-8	1986	These data are the first evidence that N-CAM is a multifunctional protein that contains both cell-and heparin (heparan sulfate)-binding domains.	Heparitin Sulfate	111-126	neural cell adhesion molecule 1	Gallus gallus	39-44
2949946-2	1986	Biochemical analyses of substratum adhesion sites indicated important functions for cell-surface heparan sulphate proteoglycan (HS-PG) in directly mediating adhesive responses by the binding of heparan sulphate sequences to fibronectin.	Heparitin Sulfate	97-113	syndecan 2	Mus musculus	128-133
2949946-2	1986	Biochemical analyses of substratum adhesion sites indicated important functions for cell-surface heparan sulphate proteoglycan (HS-PG) in directly mediating adhesive responses by the binding of heparan sulphate sequences to fibronectin.	Heparitin Sulfate	97-113	fibronectin 1	Mus musculus	224-235
3818322-9	1986	wt about 10,000) isolated from the normal and CCl4-damaged livers resulted in identifying heparan sulfate (HS).	Heparitin Sulfate	90-105	chemokine (C-C motif) ligand 4	Mus musculus	46-50
3818322-9	1986	wt about 10,000) isolated from the normal and CCl4-damaged livers resulted in identifying heparan sulfate (HS).	Heparitin Sulfate	107-109	chemokine (C-C motif) ligand 4	Mus musculus	46-50
3818322-10	1986	The 35SO4 incorporation into HS band isolated from the CCl4-damaged liver, as an indicator of HS synthesis, was increased compared with that of the normal liver.	Heparitin Sulfate	29-31	chemokine (C-C motif) ligand 4	Mus musculus	55-59
3818322-10	1986	The 35SO4 incorporation into HS band isolated from the CCl4-damaged liver, as an indicator of HS synthesis, was increased compared with that of the normal liver.	Heparitin Sulfate	94-96	chemokine (C-C motif) ligand 4	Mus musculus	55-59
3083264-6	1986	This raises the question of whether the binding of heparan sulphate to N-CAM is also required for cell-cell adhesion.	Heparitin Sulfate	51-67	neural cell adhesion molecule 1	Gallus gallus	71-76
3949798-9	1986	Heparan sulfate isolated from pig intestinal mucosa (HS I, Mr approximately 20,000) and from human aorta (HS II, Mr approximately 40,000) exhibited anti-Factor Xa activities of 180 and 20 units/micromol [corrected], respectively.	Heparitin Sulfate	0-15	aldo-keto reductase family 1 member B10	Homo sapiens	53-57
3949798-9	1986	Heparan sulfate isolated from pig intestinal mucosa (HS I, Mr approximately 20,000) and from human aorta (HS II, Mr approximately 40,000) exhibited anti-Factor Xa activities of 180 and 20 units/micromol [corrected], respectively.	Heparitin Sulfate	0-15	coagulation factor X	Homo sapiens	153-162
2436525-15	1986	Heparan sulfate did not inhibit intrinsic prothrombin activation but catalyzed the inhibition of the thrombin generated by the formation of thrombin-antithrombin III complex.	Heparitin Sulfate	0-15	coagulation factor II, thrombin	Homo sapiens	101-109
2436525-15	1986	Heparan sulfate did not inhibit intrinsic prothrombin activation but catalyzed the inhibition of the thrombin generated by the formation of thrombin-antithrombin III complex.	Heparitin Sulfate	0-15	serpin family C member 1	Homo sapiens	149-165
3816417-8	1986	The heparan sulphate from Reichert"s membrane bound to antithrombin with high affinity and was found to contain the unique 3-O-sulphated glucosamine residue previously identified in the antithrombin-binding region of heparin.	Heparitin Sulfate	4-20	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	55-67
3816417-8	1986	The heparan sulphate from Reichert"s membrane bound to antithrombin with high affinity and was found to contain the unique 3-O-sulphated glucosamine residue previously identified in the antithrombin-binding region of heparin.	Heparitin Sulfate	4-20	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	186-198
3816417-9	1986	The EHS tumour heparan sulphate showed a higher N-/O-sulphate ratio and a lower affinity for antithrombin.	Heparitin Sulfate	15-31	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	93-105
2937928-5	1986	Fifty percent of the binding of the 16S AChE was blocked by heparan sulfate, heparin, or previous treatment of the cell with heparitinase.	Heparitin Sulfate	60-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-44
4010229-4	1985	Selective and partial inhibition of cell attachment to type I collagen, and, to a lesser extent, fibronectin, occurred upon preincubating these substrates with the sulfated glycosaminoglycans, heparin and heparan sulfate, at concentrations of 1 to 100 micrograms/ml; for 3T3 cells heparin was significantly more inhibitory (mean maximal inhibition of approximately 40%) than were two heparan sulfate fractions.	Heparitin Sulfate	205-220	fibronectin 1	Mus musculus	97-108
20493103-6	1986	The existence of a heparin-binding domain in class I- and class II-A forms of AChE, opens the possibility, that heparan sulfate proteoglycans could be involved in the anchorage of both types of esterase to synaptic regions.	Heparitin Sulfate	112-127	acetylcholinesterase	Rattus norvegicus	78-82
6235872-8	1984	These results suggest that heparan sulfate acts primarily by potentiating antithrombin III, while dermatan sulfate acts by potentiating heparin cofactor II.	Heparitin Sulfate	27-42	serpin family C member 1	Homo sapiens	74-90
6468662-1	1984	The specific binding of fibronectin to collagen and heparan sulfate is important in cell adhesion and formation of connective tissue.	Heparitin Sulfate	52-67	fibronectin 1	Homo sapiens	24-35
3891641-5	1985	Five out of 7 SCC lines showed a shift in GAG production compared with normal keratinocytes, so that in these lines heparan sulphate was the major GAG as opposed to hyaluronic acid in the normal keratinocytes.	Heparitin Sulfate	116-132	serpin family B member 3	Homo sapiens	14-17
3161537-0	1985	Secondary structure of human plasma fibronectin: conformational change induced by calf alveolar heparan sulfates.	Heparitin Sulfate	96-112	fibronectin 1	Homo sapiens	36-47
3161537-3	1985	The calf alveolar heparan sulfates induced a change in the conformation of fibronectin: the magnitude of the change depended on the molecular properties of the particular heparan sulfate preparations.	Heparitin Sulfate	18-34	fibronectin 1	Bos taurus	75-86
3161537-3	1985	The calf alveolar heparan sulfates induced a change in the conformation of fibronectin: the magnitude of the change depended on the molecular properties of the particular heparan sulfate preparations.	Heparitin Sulfate	18-33	fibronectin 1	Bos taurus	75-86
3157703-0	1985	Evidence that cell surface heparan sulfate is involved in the high affinity thrombin binding to cultured porcine aortic endothelial cells.	Heparitin Sulfate	27-42	coagulation factor II, thrombin	Bos taurus	76-84
3157703-1	1985	It has been postulated that thrombin binds to endothelial cells through, at least in part, cell surface glycosaminoglycans such as heparan sulfate, which could serve as antithrombin cofactor on the endothelium.	Heparitin Sulfate	131-146	coagulation factor II, thrombin	Bos taurus	28-36
3157703-5	1985	Both specific and nonspecific binding of 125I-thrombin to the endothelial cell surface was partially inhibited in the presence of protamine sulfate, after the removal of cell surface heparan sulfate by the treatment of cells with crude Flavobacterium heparinum enzyme or purified heparitinase.	Heparitin Sulfate	183-198	coagulation factor II, thrombin	Bos taurus	46-54
3157703-10	1985	Our results provide the first direct evidence that heparan sulfate on the cell surface is involved in the high-affinity, active site-independent thrombin binding by endothelial cells, and also suggest the presence of thrombin-binding sites that are not directly related to heparan sulfate.	Heparitin Sulfate	51-66	coagulation factor II, thrombin	Bos taurus	145-153
3157703-10	1985	Our results provide the first direct evidence that heparan sulfate on the cell surface is involved in the high-affinity, active site-independent thrombin binding by endothelial cells, and also suggest the presence of thrombin-binding sites that are not directly related to heparan sulfate.	Heparitin Sulfate	51-66	coagulation factor II, thrombin	Bos taurus	217-225
6238835-1	1984	Plasma fibronectin (pFN) contains binding domains for an unidentified receptor on the surface of fibroblasts and for heparan sulfate chains of proteoglycans on these same cells.	Heparitin Sulfate	117-132	fibronectin 1	Homo sapiens	7-18
6238835-3	1984	The cell-binding fragment (CBF) of pFN was purified from chymotryptic digests free of any heparan sulfate-binding activity.	Heparitin Sulfate	90-105	CCAAT enhancer binding protein zeta	Homo sapiens	27-30
6484489-5	1984	The assay was also applied to determine the structure-function relationship of heparin and heparansulphate in activation of fibronectin.	Heparitin Sulfate	91-106	fibronectin 1	Homo sapiens	124-135
6484489-8	1984	It is concluded that the assay is very convenient to detect biological active fibronectin and to elucidate the structure-function relationship of heparin and heparansulphate in activating fibronectin.	Heparitin Sulfate	158-173	fibronectin 1	Homo sapiens	78-89
6484489-8	1984	It is concluded that the assay is very convenient to detect biological active fibronectin and to elucidate the structure-function relationship of heparin and heparansulphate in activating fibronectin.	Heparitin Sulfate	158-173	fibronectin 1	Homo sapiens	188-199
6235872-0	1984	Heparan sulfate and dermatan sulfate inhibit the generation of thrombin activity in plasma by complementary pathways.	Heparitin Sulfate	0-15	coagulation factor II, thrombin	Homo sapiens	63-71
6235872-4	1984	Heparan sulfate inhibited thrombin generation and accelerated the inactivation of added thrombin and factor Xa in normal plasma but not in antithrombin III-depleted plasma.	Heparitin Sulfate	0-15	coagulation factor II, thrombin	Homo sapiens	26-34
6235872-4	1984	Heparan sulfate inhibited thrombin generation and accelerated the inactivation of added thrombin and factor Xa in normal plasma but not in antithrombin III-depleted plasma.	Heparitin Sulfate	0-15	coagulation factor II, thrombin	Homo sapiens	88-96
6235872-4	1984	Heparan sulfate inhibited thrombin generation and accelerated the inactivation of added thrombin and factor Xa in normal plasma but not in antithrombin III-depleted plasma.	Heparitin Sulfate	0-15	coagulation factor X	Homo sapiens	101-110
6235872-6	1984	In addition, heparan sulfate was an effective inhibitor of factor Xa generation, while dermatan sulfate was not.	Heparitin Sulfate	13-28	coagulation factor X	Homo sapiens	59-68
6235872-9	1984	The inhibition of thrombin generation by heparan sulfate and dermatan sulfate thus appears to occur by complementary pathways, both of which may contribute to the anticoagulation of blood in vivo.	Heparitin Sulfate	41-56	coagulation factor II, thrombin	Homo sapiens	18-26
6321520-6	1984	However, the inhibitory effect of fibronectin was greatly enhanced by adding the protein together with heparin, heparan sulfate, collagen, or a fibronectin-binding collagen peptide (CB-7), which is consistent with an "activation" of fibronectin on binding to these matrix components.	Heparitin Sulfate	112-127	fibronectin 1	Rattus norvegicus	34-45
6746744-6	1984	The labeled proteoglycans extracted from control kidneys eluted as a single peak with Kav = 0.25 (Mr = approximately 130,000), and approximately 95% of the radioactivity was associated with heparan sulfate proteoglycan (HS-PG), the remainder with chondroitin (or dermatan) sulfate proteoglycan (CS-PG).	Heparitin Sulfate	190-205	syndecan 1	Rattus norvegicus	220-225
6231139-0	1984	Heparan sulfate and dermatan sulfate from the liver of a patient with Hurler syndrome: high performance liquid chromatography of their degradation products after incubation with alpha-L-iduronidase-deficient fibroblasts.	Heparitin Sulfate	0-15	alpha-L-iduronidase	Homo sapiens	178-197
6083829-10	1984	In contrast, heparan sulfate is associated with increased cell-substratum adhesion and is involved in the spreading of cells onto fibronectin and other substrata.	Heparitin Sulfate	13-28	fibronectin 1	Homo sapiens	130-141
6231919-3	1984	This effect of antithrombin III was potentiated by heparin, and to a modest extent by heparan sulphate, cellulose sulphate, dextran sulphate and xylan sulphate.	Heparitin Sulfate	86-102	serpin family C member 1	Homo sapiens	15-31
6352571-2	1983	It was proposed that this could reflect binding of PF4 to heparin or heparan sulphate, known granule constituents.	Heparitin Sulfate	69-85	platelet factor 4	Homo sapiens	51-54
6882775-1	1983	The interactions of bovine milk lipoprotein lipase (triacylglycero-protein acylhydrolase, EC 3.1.1.34) with the glycosaminoglycans heparin and heparan sulphate were investigated using the technique of fluorescence polarization spectroscopy.	Heparitin Sulfate	143-159	lipoprotein lipase	Bos taurus	32-50
6643486-3	1983	In low ionic strength buffer, intact fibronectin bound to heparin and high sulfated heparan sulfate, but not to low sulfated heparan sulfate, dermatan sulfate, chondroitin sulfates A and C, or hyaluronic acid.	Heparitin Sulfate	84-99	fibronectin 1	Homo sapiens	37-48
6643486-5	1983	The 150K-140K fragments exhibited the same specificities as intact fibronectin, binding only to heparin and high sulfated heparan sulfate.	Heparitin Sulfate	122-137	fibronectin 1	Homo sapiens	67-78
6224480-12	1983	It is concluded that in the low-sulphated heparan sulphates GlcNSO3 residues that do not occur in (GlcNSO3-UA-)n blocks tend to have a significantly smaller extent of C-6 O-sulphation than do GlcNAc residues that occur in -GlcNSO3-UA-GlcNAc-GlcUA-GlcNSO3-sequences.	Heparitin Sulfate	42-59	complement C6	Bos taurus	167-170
6687888-2	1983	Heparin, dermatan sulfate, and heparan sulfate from bovine liver (in order of decreasing activity) activated HCII.	Heparitin Sulfate	31-46	serpin family D member 1	Homo sapiens	109-113
6687888-3	1983	In contrast, only heparin and bovine liver heparan sulfate activated ATIII, whereas dermatan sulfate was inactive at concentrations less than or equal to 1 mg/ml.	Heparitin Sulfate	43-58	serpin family C member 1	Bos taurus	69-74
6222058-0	1983	Correlation between cell substrate attachment in vitro and cell surface heparan sulfate affinity for fibronectin and collagen.	Heparitin Sulfate	72-87	fibronectin 1	Mus musculus	101-112
6861909-4	1983	This adhesive response could be completely prevented by predigesting the cells with Flavobacterium heparanase, but not with chondroitinase ABC, indicating that the cell surface Fn responsible for antibody-mediated adhesion is associated with heparan sulfate proteoglycans on the cell surface.	Heparitin Sulfate	242-257	fibronectin 1	Rattus norvegicus	177-179
6861909-10	1983	These experiments indicate that (1) much of the cell surface fibronectin is complexed with heparan sulfate proteoglycan and is initially inaccessible to bind to polyvalent antibody on the substratum to promote adhesion; (2) the surface of neuroblastoma cells contains a fibronectin-like molecule which is important in their substratum adhesion; and (3) monoclonal antibodies are valuable tools in "mapping" the orientation of cell surface molecules like fibronectin by measuring adhesive responses to antibody-coated substrata.	Heparitin Sulfate	91-106	fibronectin 1	Rattus norvegicus	61-72
6222912-0	1983	Contact formation by fibroblasts adhering to heparan sulfate-binding substrata (fibronectin or platelet factor 4).	Heparitin Sulfate	45-60	fibronectin 1	Homo sapiens	80-91
6222912-2	1983	FN has binding domains for HS and an unidentified cell surface receptor, whereas PF4 binds to only HS on the surface of the cell.	Heparitin Sulfate	27-29	fibronectin 1	Homo sapiens	0-2
6222912-2	1983	FN has binding domains for HS and an unidentified cell surface receptor, whereas PF4 binds to only HS on the surface of the cell.	Heparitin Sulfate	99-101	platelet factor 4	Homo sapiens	81-84
6222058-3	1983	These latter heparan sulfates do, however, bind to both fibronectin and collagen, as reported earlier (Stamatoglou, S.C., and J.M.	Heparitin Sulfate	13-29	fibronectin 1	Mus musculus	56-67
6833245-10	1983	Cellular heparan sulfate decreased by 70% in response to NGF and increased by an equivalent amount in the culture medium, whereas an NGF-induced increase in chondroitin sulfate labeling occurred specifically in the cell membranes.	Heparitin Sulfate	9-24	nerve growth factor	Rattus norvegicus	57-60
6218833-7	1983	Such an excess suggests that lipoprotein lipase may interact with approximately one in four of the available heparan sulphate chains.	Heparitin Sulfate	109-125	lipoprotein lipase	Bos taurus	29-47
6220715-0	1983	Covalent binding of lactosaminoglycans and heparan sulphate to fibronectin synthesized by a human teratocarcinoma cell line.	Heparitin Sulfate	43-59	fibronectin 1	Homo sapiens	63-74
6835010-9	1983	This and other evidence suggests that the high-charge GAG in human plasma responsible for LPL activation is heparan sulfate (HS).	Heparitin Sulfate	108-123	lipoprotein lipase	Homo sapiens	90-93
6835010-9	1983	This and other evidence suggests that the high-charge GAG in human plasma responsible for LPL activation is heparan sulfate (HS).	Heparitin Sulfate	125-127	lipoprotein lipase	Homo sapiens	90-93
6218163-10	1983	A variety of mucopolysaccharides were able to inhibit interaction of C1q with 125I-LMW-Hep, the most effective being heparan sulfate and dermatan sulfate.	Heparitin Sulfate	117-132	complement C1q C chain	Homo sapiens	69-72
6402508-9	1983	The acetylation of heparan sulfate in alpha-N-acetylglucosaminidase-deficient lysosomes could be stimulated by the addition of 0.5 mM ATP.	Heparitin Sulfate	19-34	N-acetyl-alpha-glucosaminidase	Homo sapiens	38-67
6402508-12	1983	Incorporation of [3H]acetate from [3H]acetyl-CoA into heparan sulfate (by alpha-N-acetylglucosaminidase-deficient lysosomes) and into N-acetylglucosamine (by normal lysosomes) showed a similar concentration dependence.	Heparitin Sulfate	54-69	N-acetyl-alpha-glucosaminidase	Homo sapiens	74-103
6412199-3	1983	The glycoprotein fibronectin is a constituent of connective tissue with a high affinity to polyanions such as heparan sulfate or heparin.	Heparitin Sulfate	110-125	fibronectin 1	Homo sapiens	17-28
6219115-0	1983	Cell surface heparan sulfate mediates some adhesive responses to glycosaminoglycan-binding matrices, including fibronectin.	Heparitin Sulfate	13-28	fibronectin 1	Mus musculus	111-122
7171625-6	1982	Reference standard chondroitin 4-sulfate and chondroitin 6-sulfate had no effect upon heparan sulfate binding, whereas 90% of the heparan sulfate bound to fibronectin or collagen was eluted with heparin and 60% removed from fibronectin with dermatan sulfate.	Heparitin Sulfate	130-145	fibronectin 1	Mus musculus	155-166
7139602-4	1982	At saturation density in culture, the cell surface glycosaminoglycan of C1-S1 cells was approximately 80% heparan sulfate.	Heparitin Sulfate	106-121	complement component 1, s subcomponent 1	Mus musculus	72-77
6282259-7	1982	In general, HS1-HS3 were found in cell-derived heparan sulphates, whereas HS3-HS4 were present in the medium.	Heparitin Sulfate	47-64	hematopoietic cell specific Lyn substrate 1	Mus musculus	12-15
6213815-0	1982	Removal of sulfated (heparan sulfate) or nonsulfated (hyaluronic acid) glycosaminoglycans results in increased permeability of the glomerular basement membrane to 125I-bovine serum albumin.	Heparitin Sulfate	21-36	albumin	Homo sapiens	175-188
6214562-5	1982	The heparan sulfate proteoglycan was found to codistribute with fibronectin, and fibronectin and laminin gave coincidental stainings.	Heparitin Sulfate	4-19	fibronectin 1	Rattus norvegicus	64-75
6214562-10	1982	The proteoglycan may play a central role in assembly of such complexes since heparan sulfate has been shown to interact with both fibronectin and laminin.	Heparitin Sulfate	77-92	fibronectin 1	Rattus norvegicus	130-141
6282259-7	1982	In general, HS1-HS3 were found in cell-derived heparan sulphates, whereas HS3-HS4 were present in the medium.	Heparitin Sulfate	47-64	hemoglobin, activating region	Mus musculus	16-19
7309739-12	1981	The specificity of platelet endoglucuronidase and the demonstration that the preparation utilized contained no detectable protease activity is further evidence that lipoprotein lipase is bound to endothelial cell heparan sulfate or heparan sulfate-like molecules.	Heparitin Sulfate	213-228	lipoprotein lipase	Homo sapiens	165-183
7309739-12	1981	The specificity of platelet endoglucuronidase and the demonstration that the preparation utilized contained no detectable protease activity is further evidence that lipoprotein lipase is bound to endothelial cell heparan sulfate or heparan sulfate-like molecules.	Heparitin Sulfate	232-247	lipoprotein lipase	Homo sapiens	165-183
6452123-2	1980	Lipoprotein lipase (EC 3.1.1.34), which was previously shown to bind to immobilized heparin, was now found to bind also to heparan sulphate and dermatan sulphate and to some extent to chondroitin sulphate.	Heparitin Sulfate	123-139	lipoprotein lipase	Rattus norvegicus	0-18
6459128-5	1981	The free form of heparan sulfate was found to be the activator which stimulated the lipoprotein lipase reaction in vitro in the presence of apolipoprotein CII.	Heparitin Sulfate	17-32	lipoprotein lipase	Homo sapiens	84-102
6459128-5	1981	The free form of heparan sulfate was found to be the activator which stimulated the lipoprotein lipase reaction in vitro in the presence of apolipoprotein CII.	Heparitin Sulfate	17-32	apolipoprotein C2	Homo sapiens	140-158
6270157-3	1981	It is prevented from binding to the LDL receptor by an excess of unlabeled LDL or by heparin sulfate.	Heparitin Sulfate	85-100	low density lipoprotein receptor	Homo sapiens	36-48
7263639-9	1981	Heparan sulfate was present in small amounts in both PG-I and PG-II.	Heparitin Sulfate	0-15	decorin	Homo sapiens	62-67
6256752-9	1980	Because these fibroblast adhesion sites do not contain collagen, which could potentially mediate adhesion to the substratum-bound CIg, these data support other evidence that multivalent heparan sulfate proteoglycans mediate substratum adhesion of these cells by coordinate binding to fibronectin on the cell surface and CIg on the substratum.	Heparitin Sulfate	186-201	fibronectin 1	Mus musculus	284-295
6457061-0	1981	Involvement of cell surface heparin sulfate in the binding of lipoprotein lipase to cultured bovine endothelial cells.	Heparitin Sulfate	28-43	lipoprotein lipase	Bos taurus	62-80
6457061-12	1981	The removal of heparan sulfate from the cell surface by purified heparinase totally inhibited the binding of lipoprotein lipase by endothelial cells, but the removal of chondroitin sulfate by chondroitin ABC lyase had no effect on this binding.	Heparitin Sulfate	15-30	lipoprotein lipase	Bos taurus	109-127
6457061-13	1981	These results provide direct evidence for lipoprotein lipase attachment to endothelial cells through heparan sulfate on the cell surface, and provide evidence for the release of lipoprotein lipase by heparin through a detachment from this binding site.	Heparitin Sulfate	101-116	lipoprotein lipase	Bos taurus	42-60
7419968-8	1980	These observations are consistent with the proposal that a major portion of endothelium-bound thrombin may be associated with pericellular heparan sulfate; heparin competes for thrombin with the heparan sulfate sites, and because of its higher affinity for thrombin, heparin displaces bound thrombin from, or inhibits binding of free thrombin by, the endothelium.	Heparitin Sulfate	139-154	prothrombin	Oryctolagus cuniculus	94-102
7419968-8	1980	These observations are consistent with the proposal that a major portion of endothelium-bound thrombin may be associated with pericellular heparan sulfate; heparin competes for thrombin with the heparan sulfate sites, and because of its higher affinity for thrombin, heparin displaces bound thrombin from, or inhibits binding of free thrombin by, the endothelium.	Heparitin Sulfate	195-210	prothrombin	Oryctolagus cuniculus	94-102
161508-1	1979	Oligosaccharides obtained from heparan sulphate by nitrous acid degradation were shown to be degraded sequentially by beta-D-glucuronidase or alpha-L-iduronidase followed by alpha D-N-acetylglucosaminidase.	Heparitin Sulfate	31-47	glucuronidase beta	Homo sapiens	118-138
6771264-3	1980	Fibronectin isolated from chick embryo fibroblasts binds both hyaluronic acid and heparin; heparan sulfate is bound less efficiently, and chondroitin sulfate and glycopeptides are bound minimally.	Heparitin Sulfate	91-106	fibronectin 1	Gallus gallus	0-11
7368150-3	1980	A semi-synthetic heparin analogue showed no evidence of binding to At III, but a sample of heparan sulphate did interact with At III at a concentration 3 times that of heparin.	Heparitin Sulfate	91-107	serpin family C member 1	Homo sapiens	126-132
161508-1	1979	Oligosaccharides obtained from heparan sulphate by nitrous acid degradation were shown to be degraded sequentially by beta-D-glucuronidase or alpha-L-iduronidase followed by alpha D-N-acetylglucosaminidase.	Heparitin Sulfate	31-47	alpha-L-iduronidase	Homo sapiens	142-161
148364-2	1978	High concentrations of chondroitin sulphate A, B and C and heparitin sulphate partly or completely inhibited the response of CFU-E to erythropoietin stimulation whereas addition of heparin, hyalyronic acid and keratan sulphate II in concentrations up to 100 microgram/ml did not elicit an inhibition of erythrocytic colony formation.	Heparitin Sulfate	59-77	erythropoietin	Mus musculus	134-148
153251-3	1979	Cultured skin fibroblasts from both insulin-dependent and noninsulin-dependent diabetics were found to have increased proportions of heparan sulfate in the media relative to the other sulfated glycosaminoglycans.	Heparitin Sulfate	133-148	insulin	Homo sapiens	36-43
155819-9	1979	The results demonstrate that the sites contain heparan sulfate since they are removed by treatment with heparitinase and by nitrous acid oxidation-procedures specific for heparan sulfate; and that sialoglycoproteins or other glycosaminoglycans do not represent major components of these sites since the latter are not affected by digestion with neuraminidase and other glycosaminoglycan-specific enzymes.	Heparitin Sulfate	47-62	neuraminidase 1	Homo sapiens	345-358
154210-2	1978	The degradation of dermatan sulphate and heparan sulphate is disturbed due to alpha-L-iduronidase deficiency, leading to intracellular storage and excessive urinary secretion of these substances.	Heparitin Sulfate	41-57	alpha-L-iduronidase	Homo sapiens	78-97
102641-3	1978	This patient exhibited a high level of urinary excretion of dermatan sulfate and heparan sulfate, which could be interpreted in terms of her low alpha-L-iduronidase activity.	Heparitin Sulfate	81-96	alpha-L-iduronidase	Homo sapiens	145-164
33742285-0	2021	Prognostic impact of the glypican family of heparan sulfate proteoglycans on the survival of breast cancer patients.	Heparitin Sulfate	44-59	glypican 1	Homo sapiens	25-33
409573-2	1977	We have demonstrated complete inhibition of GM1 ganglioside beta-galactosidase activity in vitro by both heparan sulfate and dermatan sulfate, but the effect on lactosylceramide and galactosylceramide hydrolysis was less marked.	Heparitin Sulfate	105-120	galactosidase beta 1	Homo sapiens	60-78
33284486-7	2021	Furthermore, the interaction of mesoglycan with syndecan 4 (SDC4), a coreceptor belonging to the class of heparan sulfate proteoglycans, represents the upstream event of the ANXA2 behavior.	Heparitin Sulfate	106-121	syndecan 4	Homo sapiens	48-58
33284486-7	2021	Furthermore, the interaction of mesoglycan with syndecan 4 (SDC4), a coreceptor belonging to the class of heparan sulfate proteoglycans, represents the upstream event of the ANXA2 behavior.	Heparitin Sulfate	106-121	syndecan 4	Homo sapiens	60-64
33284486-7	2021	Furthermore, the interaction of mesoglycan with syndecan 4 (SDC4), a coreceptor belonging to the class of heparan sulfate proteoglycans, represents the upstream event of the ANXA2 behavior.	Heparitin Sulfate	106-121	annexin A2	Homo sapiens	174-179
33781652-4	2021	Subsequent analysis of CXCL8- and CCL2-induced chemotaxis revealed that leukocyte migration was strongly reduced after eliminating heparan sulfate from the surface of neutrophils and monocytes.	Heparitin Sulfate	131-146	C-X-C motif chemokine ligand 8	Homo sapiens	23-28
33781652-4	2021	Subsequent analysis of CXCL8- and CCL2-induced chemotaxis revealed that leukocyte migration was strongly reduced after eliminating heparan sulfate from the surface of neutrophils and monocytes.	Heparitin Sulfate	131-146	C-C motif chemokine ligand 2	Homo sapiens	34-38
33758009-0	2021	Hypercholesterolemia in Progressive Renal Failure Is Associated with Changes in Hepatic Heparan Sulfate - PCSK9 Interaction.	Heparitin Sulfate	88-103	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	106-111
34059731-0	2021	Heparan sulfate proteoglycan glypican-1 and PECAM-1 cooperate in shear-induced endothelial nitric oxide production.	Heparitin Sulfate	0-15	glypican 1	Homo sapiens	29-39
33609572-0	2021	Proteinuria converts hepatic heparan sulfate to an effective proprotein convertase subtilisin kexin type 9 enzyme binding partner.	Heparitin Sulfate	29-44	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	61-106
33609572-2	2021	Heparan sulfate proteoglycan also mediates low-density lipoprotein receptor degradation by a regulator of cholesterol homeostasis, proprotein convertase subtilisin kexin type 9 (PCSK9), thereby hampering triglyceride-rich remnant lipoproteins uptake.	Heparitin Sulfate	0-15	low density lipoprotein receptor	Rattus norvegicus	43-75
33609572-2	2021	Heparan sulfate proteoglycan also mediates low-density lipoprotein receptor degradation by a regulator of cholesterol homeostasis, proprotein convertase subtilisin kexin type 9 (PCSK9), thereby hampering triglyceride-rich remnant lipoproteins uptake.	Heparitin Sulfate	0-15	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	131-176
33609572-2	2021	Heparan sulfate proteoglycan also mediates low-density lipoprotein receptor degradation by a regulator of cholesterol homeostasis, proprotein convertase subtilisin kexin type 9 (PCSK9), thereby hampering triglyceride-rich remnant lipoproteins uptake.	Heparitin Sulfate	0-15	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	178-183
33609572-9	2021	PCSK9 partly colocalized with hypersulfated heparan sulfate in proteinuric rats, but not in control rats.	Heparitin Sulfate	44-59	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	0-5
33609572-10	2021	Hence, proteinuria induces hypersulfated hepatic heparan sulfate proteoglycans, increasing their affinity to PCSK9.	Heparitin Sulfate	49-64	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	109-114
33846619-0	2021	Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate.	Heparitin Sulfate	70-85	lysine demethylase 2B	Homo sapiens	28-33
34042151-0	2021	A novel mutation in ext2 caused hereditary multiple exostoses through reducing the synthesis of heparan sulfate.	Heparitin Sulfate	96-111	exostosin glycosyltransferase 2	Homo sapiens	20-24
34042151-2	2021	Over 70% of HME cases arise from monoallelic mutations in either of the two genes encoding the heparan sulfate (HS) synthesis enzymes, ext1 and ext2.	Heparitin Sulfate	95-110	exostosin glycosyltransferase 1	Homo sapiens	135-139
34042151-2	2021	Over 70% of HME cases arise from monoallelic mutations in either of the two genes encoding the heparan sulfate (HS) synthesis enzymes, ext1 and ext2.	Heparitin Sulfate	95-110	exostosin glycosyltransferase 2	Homo sapiens	144-148
34042151-2	2021	Over 70% of HME cases arise from monoallelic mutations in either of the two genes encoding the heparan sulfate (HS) synthesis enzymes, ext1 and ext2.	Heparitin Sulfate	112-114	exostosin glycosyltransferase 1	Homo sapiens	135-139
34042151-2	2021	Over 70% of HME cases arise from monoallelic mutations in either of the two genes encoding the heparan sulfate (HS) synthesis enzymes, ext1 and ext2.	Heparitin Sulfate	112-114	exostosin glycosyltransferase 2	Homo sapiens	144-148
34042151-5	2021	Although the resulting truncated protein was still localized to the Golgi, similar to the full-length EXT2, its HS synthesis activity decreased by 40%.	Heparitin Sulfate	112-114	exostosin glycosyltransferase 2	Homo sapiens	102-106
34004353-9	2021	These results strongly imply that Hpa2 functions as a tumor suppressor in head and neck cancer, involving Sox2 upregulation mediated, in part, by the high-affinity interaction of Hpa2 with heparan sulfate.	Heparitin Sulfate	189-204	heparanase 2 (inactive)	Homo sapiens	34-38
34013835-0	2021	Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate.	Heparitin Sulfate	136-151	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	46-51
34013835-4	2021	In addition, hypoxia inhibits the binding of the spike to NCI-H460 human lung epithelial cells by decreasing the cell surface levels of heparan sulfate (HS), a known attachment receptor of SARS-CoV-2.	Heparitin Sulfate	136-151	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	49-54
34013835-4	2021	In addition, hypoxia inhibits the binding of the spike to NCI-H460 human lung epithelial cells by decreasing the cell surface levels of heparan sulfate (HS), a known attachment receptor of SARS-CoV-2.	Heparitin Sulfate	153-155	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	49-54
34016163-1	2021	BACKGROUND: The endoglycosidase heparanase which degrades heparan sulfate proteoglycans, exerts a pro-inflammatory mediator in various inflammatory disorders.	Heparitin Sulfate	58-73	heparanase	Mus musculus	16-42
33999952-6	2021	RESULTS: Compared with immediately before aortic declamping, arterial syndecan-1 increased by 18% [253.8 (151.6-372.0) ng/ml vs. 299.1 (172.0-713.7) ng/ml, p < 0.001] but arterial heparan sulfate decreased by 14% [148.1 (135.7-161.7) ng/ml vs. 128.0 (119.0-138.2) ng/ml, p < 0.001] at one minute after aortic declamping.	Heparitin Sulfate	180-195	syndecan 1	Homo sapiens	70-80
34004353-9	2021	These results strongly imply that Hpa2 functions as a tumor suppressor in head and neck cancer, involving Sox2 upregulation mediated, in part, by the high-affinity interaction of Hpa2 with heparan sulfate.	Heparitin Sulfate	189-204	SRY-box transcription factor 2	Homo sapiens	106-110
34004353-9	2021	These results strongly imply that Hpa2 functions as a tumor suppressor in head and neck cancer, involving Sox2 upregulation mediated, in part, by the high-affinity interaction of Hpa2 with heparan sulfate.	Heparitin Sulfate	189-204	heparanase 2 (inactive)	Homo sapiens	179-183
33744761-2	2021	Basic fibroblast growth factor (bFGF1) similarly interacts with heparin-like molecules, notably heparan sulfate proteoglycans (HSPG), in the extracellular matrix and on cell surfaces.	Heparitin Sulfate	96-111	syndecan 2	Mus musculus	127-131
33997891-8	2021	For CgA, the glycosylation site carried either CS or HS, making it a so-called hybrid site.	Heparitin Sulfate	53-55	chromogranin A	Mus musculus	4-7
33983408-0	2021	Specific heparan sulfate modifications stabilize the synaptic organizer MADD-4/Punctin at C. elegans neuromuscular junctions.	Heparitin Sulfate	9-24	Protein madd-4	Caenorhabditis elegans	72-78
33983408-7	2021	Using single chain antibodies that recognize different heparan sulfate modification patterns, we show in vivo that these two heparan sulfate epitopes are carried by the SDN-1 core protein, the unique C. elegans syndecan orthologue, at neuromuscular junctions.	Heparitin Sulfate	55-70	Syndecan;putative syndecan	Caenorhabditis elegans	169-174
33983408-7	2021	Using single chain antibodies that recognize different heparan sulfate modification patterns, we show in vivo that these two heparan sulfate epitopes are carried by the SDN-1 core protein, the unique C. elegans syndecan orthologue, at neuromuscular junctions.	Heparitin Sulfate	125-140	Syndecan;putative syndecan	Caenorhabditis elegans	169-174
33744761-7	2021	Consequently, even though bFGF and p5R both interact with heparan sulfate moieties, p5R binding was restricted to HSPG in amyloid deposits and did not bind HSPG in healthy tissues, whereas bFGF preferentially reacted with HSPG in normal tissue.	Heparitin Sulfate	58-73	fibroblast growth factor 2	Mus musculus	26-30
32638071-1	2021	Glypican-3 (GPC3) is considered as a cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	50-65	glypican 3	Mus musculus	0-10
32985651-0	2021	Human diamine oxidase cellular binding and internalization in vitro and rapid clearance in vivo are not mediated by N-glycans but by heparan sulfate proteoglycan interactions.	Heparitin Sulfate	133-148	amine oxidase copper containing 1	Homo sapiens	6-21
32638071-1	2021	Glypican-3 (GPC3) is considered as a cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	50-65	glypican 3	Mus musculus	12-16
33924175-1	2021	Antithrombin (AT) is a natural anticoagulant that interacts with activated proteases of the coagulation system and with heparan sulfate proteoglycans (HSPG) on the surface of cells.	Heparitin Sulfate	120-135	serpin family C member 1	Homo sapiens	0-12
33607500-0	2021	Binding of the human antioxidation protein alpha1-microglobulin (A1M) to heparin and heparan sulfate.	Heparitin Sulfate	85-100	alpha-1-microglobulin/bikunin precursor	Homo sapiens	65-68
33607500-11	2021	The discovery of the binding of A1M to heparin and HS provides new insights into the biological role of A1M and represents the basis for a novel method for purification of A1M from plasma.	Heparitin Sulfate	51-53	PZP, alpha-2-macroglobulin like	Mus musculus	32-35
33607500-11	2021	The discovery of the binding of A1M to heparin and HS provides new insights into the biological role of A1M and represents the basis for a novel method for purification of A1M from plasma.	Heparitin Sulfate	51-53	PZP, alpha-2-macroglobulin like	Mus musculus	104-107
33607500-11	2021	The discovery of the binding of A1M to heparin and HS provides new insights into the biological role of A1M and represents the basis for a novel method for purification of A1M from plasma.	Heparitin Sulfate	51-53	PZP, alpha-2-macroglobulin like	Mus musculus	104-107
33927256-4	2021	The current study elucidates the significance of glypican-1 (GPC-1), a heparan sulfate proteoglycan, in regulating the activation of human bone marrow-derived stromal cells (BSCs) of fibroblast lineage (HS-5).	Heparitin Sulfate	71-86	glypican 1	Homo sapiens	49-59
33927256-4	2021	The current study elucidates the significance of glypican-1 (GPC-1), a heparan sulfate proteoglycan, in regulating the activation of human bone marrow-derived stromal cells (BSCs) of fibroblast lineage (HS-5).	Heparitin Sulfate	71-86	glypican 1	Homo sapiens	61-66
33997316-1	2021	Syndecan-1 and syndecan-4 are members of the syndecan family of transmembrane heparan sulfate proteoglycans.	Heparitin Sulfate	78-93	syndecan 1	Bos taurus	0-10
33997316-1	2021	Syndecan-1 and syndecan-4 are members of the syndecan family of transmembrane heparan sulfate proteoglycans.	Heparitin Sulfate	78-93	syndecan 4	Bos taurus	15-25
33692650-3	2021	Retention of neutrophil elastase within NETs is provided by ejected DNA chains, although this protein is also capable of interacting with a range of other endogenous polyanions, such as heparin and heparan sulfate.	Heparitin Sulfate	198-213	elastase, neutrophil expressed	Homo sapiens	13-32
33915212-10	2021	Heparin-binding to the open conformation of spike structurally supports the state and may aid ACE2 binding as reported with cell surface-bound heparan sulfate.	Heparitin Sulfate	143-158	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	44-49
33915212-10	2021	Heparin-binding to the open conformation of spike structurally supports the state and may aid ACE2 binding as reported with cell surface-bound heparan sulfate.	Heparitin Sulfate	143-158	angiotensin converting enzyme 2	Homo sapiens	94-98
33923753-2	2021	VEGFR2 can interact with VEGFR2 co-receptors such as heparan sulfate proteoglycans (HSPGs) and neuropilin 2 (NRP2), but the exact roles of these co-receptors, or of sulfatase 2 (SULF2), an enzyme that removes sulfate groups from HSPGs and inhibits HSPG-mediated uptake of very low density lipoprotein (VLDL), in angiogenesis and tip cell biology are unknown.	Heparitin Sulfate	53-68	kinase insert domain receptor	Homo sapiens	0-6
33921767-3	2021	Syndecan-1 is mostly restricted to epithelia, and bears heparan sulfate chains that are capable of interacting with a large array of polypeptides, including extracellular matrix components and potent mediators of proliferation, adhesion and migration.	Heparitin Sulfate	56-71	syndecan 1	Homo sapiens	0-10
33863273-2	2021	Extracellular matrix (ECM) components in animals include heparan-sulfate proteoglycans, which are analogs of bacterial peptidoglycan and are involved in the extracellular distribution of Shh.	Heparitin Sulfate	57-72	sonic hedgehog signaling molecule	Homo sapiens	187-190
33923753-2	2021	VEGFR2 can interact with VEGFR2 co-receptors such as heparan sulfate proteoglycans (HSPGs) and neuropilin 2 (NRP2), but the exact roles of these co-receptors, or of sulfatase 2 (SULF2), an enzyme that removes sulfate groups from HSPGs and inhibits HSPG-mediated uptake of very low density lipoprotein (VLDL), in angiogenesis and tip cell biology are unknown.	Heparitin Sulfate	53-68	kinase insert domain receptor	Homo sapiens	25-31
33920100-2	2021	Previous research indicated that CHI3L1 is able to interact with different extracellular matrix components, such as heparan sulfate.	Heparitin Sulfate	116-131	chitinase 3 like 1	Homo sapiens	33-39
33851732-5	2021	In addition to ACE2, several recent studies have implicated the crucial role cell surface heparan sulfate (HS) as a necessary assisting co-factor for ACE2-mediated SARS-CoV-2 entry.	Heparitin Sulfate	90-105	angiotensin converting enzyme 2	Homo sapiens	150-154
33851732-5	2021	In addition to ACE2, several recent studies have implicated the crucial role cell surface heparan sulfate (HS) as a necessary assisting co-factor for ACE2-mediated SARS-CoV-2 entry.	Heparitin Sulfate	107-109	angiotensin converting enzyme 2	Homo sapiens	150-154
33704312-0	2021	Synthetic heparan sulfate ligands for vascular endothelial growth factor to modulate angiogenesis.	Heparitin Sulfate	10-25	vascular endothelial growth factor A	Homo sapiens	38-72
33920100-5	2021	Using a solid-phase binding assay, we found that heparan sulfate-bound VEGF-A and CCL2 were displaced by recombinant CHI3L1 in a dose-dependent manner.	Heparitin Sulfate	49-64	vascular endothelial growth factor A	Homo sapiens	71-77
33920100-5	2021	Using a solid-phase binding assay, we found that heparan sulfate-bound VEGF-A and CCL2 were displaced by recombinant CHI3L1 in a dose-dependent manner.	Heparitin Sulfate	49-64	C-C motif chemokine ligand 2	Homo sapiens	82-86
33920100-5	2021	Using a solid-phase binding assay, we found that heparan sulfate-bound VEGF-A and CCL2 were displaced by recombinant CHI3L1 in a dose-dependent manner.	Heparitin Sulfate	49-64	chitinase 3 like 1	Homo sapiens	117-123
32651954-1	2021	Glucuronyl C5-epimerase (Hsepi) is a key enzyme in the biosynthesis of heparan sulfate that is a sulfated polysaccharide expressed on the cell surface and in the extracellular matrix of alveolar walls and blood vessels.	Heparitin Sulfate	71-86	glucuronyl C5-epimerase	Mus musculus	0-23
33586859-0	2021	CA10 regulates neurexin heparan sulfate addition via a direct binding in the secretory pathway.	Heparitin Sulfate	24-39	carbonic anhydrase 10	Homo sapiens	0-4
33687395-0	2021	Convergent chemoenzymatic synthesis and biological evaluation of a heparan sulfate proteoglycan syndecan-1 mimetic.	Heparitin Sulfate	67-82	syndecan 1	Homo sapiens	96-106
33889573-1	2021	Background: Sulfatase 2 (SULF2) removes the 6-O-sulfate groups from heparan sulfate proteoglycans (HSPG) and consequently alters the binding sites for various signaling molecules.	Heparitin Sulfate	68-83	sulfatase 2	Mus musculus	12-23
33889573-1	2021	Background: Sulfatase 2 (SULF2) removes the 6-O-sulfate groups from heparan sulfate proteoglycans (HSPG) and consequently alters the binding sites for various signaling molecules.	Heparitin Sulfate	68-83	sulfatase 2	Mus musculus	25-30
33889573-1	2021	Background: Sulfatase 2 (SULF2) removes the 6-O-sulfate groups from heparan sulfate proteoglycans (HSPG) and consequently alters the binding sites for various signaling molecules.	Heparitin Sulfate	68-83	syndecan 2	Mus musculus	99-103
33269518-3	2021	This function is thought to be fostered by the heparan sulfate chains attached to the domain I of vertebrate Pcan.	Heparitin Sulfate	47-62	terribly reduced optic lobes	Drosophila melanogaster	109-113
33515635-2	2021	Previous studies of the nervous system suggest that heparan sulfate proteoglycans can inactivate PTPsigma by clustering PTPsigma receptors on neurons, but this finding has yet to be visually verified with adequate resolution.	Heparitin Sulfate	52-67	protein tyrosine phosphatase receptor type S	Homo sapiens	97-105
33515635-2	2021	Previous studies of the nervous system suggest that heparan sulfate proteoglycans can inactivate PTPsigma by clustering PTPsigma receptors on neurons, but this finding has yet to be visually verified with adequate resolution.	Heparitin Sulfate	52-67	protein tyrosine phosphatase receptor type S	Homo sapiens	120-128
33515635-3	2021	Here, we sought to visualize and quantify how heparan sulfate proteoglycans regulate the organization and activation of PTPsigma in hematopoietic stem/progenitor cells (HSPCs).	Heparitin Sulfate	46-61	protein tyrosine phosphatase receptor type S	Homo sapiens	120-128
32909036-8	2021	Overall, our study provides structural details for a new type of galectin-sugar interaction that broadens glycospace for ligand binding to Gal-3 and suggests how the lectin may recognize other negatively charged polysaccharides like glycoaminoglycans (e.g. heparan sulfate) on the cell surface.	Heparitin Sulfate	257-272	galectin 3	Homo sapiens	139-144
32651954-1	2021	Glucuronyl C5-epimerase (Hsepi) is a key enzyme in the biosynthesis of heparan sulfate that is a sulfated polysaccharide expressed on the cell surface and in the extracellular matrix of alveolar walls and blood vessels.	Heparitin Sulfate	71-86	glucuronyl C5-epimerase	Mus musculus	25-30
33239522-2	2021	Glypican-3 (GPC3) is a member of the heparan sulfate proteoglycan family of proteins and is highly expressed in hepatocellular carcinoma (HCC) cell membranes.	Heparitin Sulfate	37-52	glypican 3	Mus musculus	0-10
33239522-2	2021	Glypican-3 (GPC3) is a member of the heparan sulfate proteoglycan family of proteins and is highly expressed in hepatocellular carcinoma (HCC) cell membranes.	Heparitin Sulfate	37-52	glypican 3	Mus musculus	12-16
33691578-1	2021	PURPOSE: Heparanase is an endo-beta-glucuronidase that cleaves side chains of heparan-sulfate proteoglycans, an integral constituent of the extra cellular matrix.	Heparitin Sulfate	78-93	heparanase	Homo sapiens	9-19
33513400-7	2021	Additionally, OXT can promote gamma-interferon expression to inhibit cathepsin L and increases superoxide dismutase expression to reduce heparin and heparan sulphate fragmentation.	Heparitin Sulfate	149-165	oxytocin/neurophysin I prepropeptide	Homo sapiens	14-17
33791697-2	2021	The interaction of SARS-CoV-2 spike protein with cell surface heparan sulfate (HS) promotes viral entry 3 .	Heparitin Sulfate	62-77	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	30-35
33791697-2	2021	The interaction of SARS-CoV-2 spike protein with cell surface heparan sulfate (HS) promotes viral entry 3 .	Heparitin Sulfate	79-81	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	30-35
33735525-2	2021	Here we report a novel mechanistic role for the heparan sulfate editing enzyme sulfatase 2 (SULF2) in CCA pathogenesis.	Heparitin Sulfate	48-63	sulfatase 2	Homo sapiens	79-90
33735525-2	2021	Here we report a novel mechanistic role for the heparan sulfate editing enzyme sulfatase 2 (SULF2) in CCA pathogenesis.	Heparitin Sulfate	48-63	sulfatase 2	Homo sapiens	92-97
33839004-1	2021	Mucopolysaccharidosis IIIB (MPS IIIB, Sanfilippo syndrome type B) is caused by a deficiency in alpha-N-acetylglucosaminidase (NAGLU) activity, which leads to the accumulation of heparan sulfate (HS).	Heparitin Sulfate	178-193	N-acetyl-alpha-glucosaminidase	Homo sapiens	28-36
33839004-1	2021	Mucopolysaccharidosis IIIB (MPS IIIB, Sanfilippo syndrome type B) is caused by a deficiency in alpha-N-acetylglucosaminidase (NAGLU) activity, which leads to the accumulation of heparan sulfate (HS).	Heparitin Sulfate	178-193	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	95-124
33839004-1	2021	Mucopolysaccharidosis IIIB (MPS IIIB, Sanfilippo syndrome type B) is caused by a deficiency in alpha-N-acetylglucosaminidase (NAGLU) activity, which leads to the accumulation of heparan sulfate (HS).	Heparitin Sulfate	178-193	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	126-131
33860088-3	2021	Our recent study revealed that sulfated glycosaminoglycans, especially highly sulfated domains of heparan sulfate (heparan sulfate S-domains), participate in cancer pathology by mediating transcellular propagation of p53 aggregates.	Heparitin Sulfate	98-113	tumor protein p53	Homo sapiens	217-220
33860088-3	2021	Our recent study revealed that sulfated glycosaminoglycans, especially highly sulfated domains of heparan sulfate (heparan sulfate S-domains), participate in cancer pathology by mediating transcellular propagation of p53 aggregates.	Heparitin Sulfate	115-130	tumor protein p53	Homo sapiens	217-220
33755115-0	2021	Re-expression of glucuronyl C5-epimerase in the mutant MEF cells increases heparan sulfate epimerization but has no influence on the Golgi localization and enzymatic activity of 2-O-sulfotransferase.	Heparitin Sulfate	75-90	glucuronyl C5-epimerase	Mus musculus	17-40
33755115-0	2021	Re-expression of glucuronyl C5-epimerase in the mutant MEF cells increases heparan sulfate epimerization but has no influence on the Golgi localization and enzymatic activity of 2-O-sulfotransferase.	Heparitin Sulfate	75-90	E74-like factor 4 (ets domain transcription factor)	Mus musculus	55-58
33718824-1	2021	The lon-2 gene in Caenorhabditis elegans encodes a heparan sulfate proteoglycan family glypican that negatively regulates the BMP signaling pathway responsible for controlling body length.	Heparitin Sulfate	51-66	LONg	Caenorhabditis elegans	4-9
33718824-1	2021	The lon-2 gene in Caenorhabditis elegans encodes a heparan sulfate proteoglycan family glypican that negatively regulates the BMP signaling pathway responsible for controlling body length.	Heparitin Sulfate	51-66	GlyPicaN	Caenorhabditis elegans	87-95
33606708-1	2021	Glypican-5 (GPC5) is a heparan sulfate proteoglycan (HSPG) localized to the plasma membrane.	Heparitin Sulfate	23-38	glypican 5	Homo sapiens	0-10
33357145-1	2021	Syndecan-1 (SDC1) belongs to heparan sulfate proteoglycans which may interact with different growth factors, cytokines, morphogens and promote tumor growth and invasion.	Heparitin Sulfate	29-44	syndecan 1	Homo sapiens	0-10
33357145-1	2021	Syndecan-1 (SDC1) belongs to heparan sulfate proteoglycans which may interact with different growth factors, cytokines, morphogens and promote tumor growth and invasion.	Heparitin Sulfate	29-44	syndecan 1	Homo sapiens	12-16
33617524-6	2021	We consider Shh aggregate formation to comprise of multimerisation, association with heparan sulfate proteoglycans (HSPG) and binding with lipoproteins.	Heparitin Sulfate	85-100	sonic hedgehog signaling molecule	Homo sapiens	12-15
33472827-2	2021	In this study using animals of both sexes, we investigated the role of heparan sulfate proteoglycans in the modulation of IFN-gamma signaling following demyelination.	Heparitin Sulfate	71-86	interferon gamma	Homo sapiens	122-131
33472827-6	2021	We found that PI-88, a heparan sulfate mimetic, directly antagonized IFN-gamma to rescue human OPC proliferation and differentiation in vitro and blocked the IFN-gamma mediated inhibitory effects on OPC recruitment in vivo Importantly, heparanase modulation by PI-88 or OGT2155 in demyelinated lesion rescued IFN-gamma mediated axonal damage and demyelination.	Heparitin Sulfate	23-38	interferon gamma	Homo sapiens	69-78
33051777-1	2021	Heparanase is the predominant enzyme that cleaves heparan sulfate, the main polysaccharide in the extracellular matrix.	Heparitin Sulfate	50-65	heparanase	Mus musculus	0-10
33606708-1	2021	Glypican-5 (GPC5) is a heparan sulfate proteoglycan (HSPG) localized to the plasma membrane.	Heparitin Sulfate	23-38	glypican 5	Homo sapiens	12-16
32785657-4	2021	In MDCK cells (Distal tubular cell) and NRK-52E (Proximal tubular cell), AMPK inhibition resulted in increased sGAG levels under normal glucose conditions characteristically of heparan sulfate class, whereas AMPK activation did not have any effect.	Heparitin Sulfate	177-192	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	73-77
33039540-0	2021	A biomimetic collagen-bone granule-heparan sulfate combination scaffold for BMP2 delivery.	Heparitin Sulfate	35-50	bone morphogenetic protein 2	Bos taurus	76-80
33039540-4	2021	Here we report on a biomimetic scaffold consisting of bovine collagen type I, bone granules (IntergraftTM), and heparan sulfate with increased affinity for BMP2 (HS3).	Heparitin Sulfate	112-127	bone morphogenetic protein 2	Bos taurus	156-160
33580179-0	2021	pH-dependent and dynamic interactions of cystatin C with heparan sulfate.	Heparitin Sulfate	57-72	cystatin C	Mus musculus	41-51
33580179-3	2021	Here we investigated the interaction between Cst-3 and heparan sulfate (HS), a major component of extracellular matrix.	Heparitin Sulfate	55-70	cystatin C	Mus musculus	45-50
33580179-3	2021	Here we investigated the interaction between Cst-3 and heparan sulfate (HS), a major component of extracellular matrix.	Heparitin Sulfate	72-74	cystatin C	Mus musculus	45-50
33580179-7	2021	We further discovered that HS-binding severely impairs the inhibitory activity of Cst-3 towards papain, suggesting the interaction could actively regulate Cst-3 activity.	Heparitin Sulfate	27-29	cystatin C	Mus musculus	82-87
33580179-7	2021	We further discovered that HS-binding severely impairs the inhibitory activity of Cst-3 towards papain, suggesting the interaction could actively regulate Cst-3 activity.	Heparitin Sulfate	27-29	cystatin C	Mus musculus	155-160
33595099-8	2021	CLR for heparan sulfate increased with interleukin-6 (P< 0.003) and the urine flow (P< 0.01).	Heparitin Sulfate	8-23	interleukin 6	Homo sapiens	39-52
33592143-1	2021	Heparan sulfate (HS) can play important roles in the biology and pathology of amyloid beta (Abeta), a hallmark of Alzheimer"s disease.	Heparitin Sulfate	0-15	amyloid beta precursor protein	Homo sapiens	78-90
33592143-1	2021	Heparan sulfate (HS) can play important roles in the biology and pathology of amyloid beta (Abeta), a hallmark of Alzheimer"s disease.	Heparitin Sulfate	0-15	amyloid beta precursor protein	Homo sapiens	92-97
33592143-1	2021	Heparan sulfate (HS) can play important roles in the biology and pathology of amyloid beta (Abeta), a hallmark of Alzheimer"s disease.	Heparitin Sulfate	17-19	amyloid beta precursor protein	Homo sapiens	78-90
33592143-1	2021	Heparan sulfate (HS) can play important roles in the biology and pathology of amyloid beta (Abeta), a hallmark of Alzheimer"s disease.	Heparitin Sulfate	17-19	amyloid beta precursor protein	Homo sapiens	92-97
33278943-0	2021	The abnormal accumulation of heparan sulfate in patients with mucopolysaccharidosis prevents the elastolytic activity of cathepsin V.	Heparitin Sulfate	29-44	cathepsin V	Homo sapiens	121-132
33562126-4	2021	Syndecan-1 (SDC-1) is a transmembrane heparan sulfate proteoglycan that acts as a co-receptor in various cellular processes including angiogenesis.	Heparitin Sulfate	38-53	syndecan 1	Homo sapiens	0-10
33562126-4	2021	Syndecan-1 (SDC-1) is a transmembrane heparan sulfate proteoglycan that acts as a co-receptor in various cellular processes including angiogenesis.	Heparitin Sulfate	38-53	syndecan 1	Homo sapiens	12-17
33278943-7	2021	HS bound tightly to CatV and impaired its activity.	Heparitin Sulfate	0-2	cathepsin V	Homo sapiens	20-24
33246160-2	2021	Syndecan-4 (Sdc4) is a heparan sulfate proteoglycan, expressed under inflammatory conditions and by chondrocytes during OA.	Heparitin Sulfate	23-38	syndecan 4	Homo sapiens	0-10
33197333-1	2021	Heparin and heparan sulfate (HS) are highly sulfated polysaccharides covalently bound to cell surface proteins, which directly interact with many extracellular proteins, including the transforming growth factor-beta (TGFbeta) family ligand antagonist, follistatin 288 (FS288).	Heparitin Sulfate	12-27	tumor necrosis factor	Homo sapiens	184-215
33197333-1	2021	Heparin and heparan sulfate (HS) are highly sulfated polysaccharides covalently bound to cell surface proteins, which directly interact with many extracellular proteins, including the transforming growth factor-beta (TGFbeta) family ligand antagonist, follistatin 288 (FS288).	Heparitin Sulfate	12-27	transforming growth factor alpha	Homo sapiens	217-224
33197333-1	2021	Heparin and heparan sulfate (HS) are highly sulfated polysaccharides covalently bound to cell surface proteins, which directly interact with many extracellular proteins, including the transforming growth factor-beta (TGFbeta) family ligand antagonist, follistatin 288 (FS288).	Heparitin Sulfate	29-31	tumor necrosis factor	Homo sapiens	184-215
33197333-1	2021	Heparin and heparan sulfate (HS) are highly sulfated polysaccharides covalently bound to cell surface proteins, which directly interact with many extracellular proteins, including the transforming growth factor-beta (TGFbeta) family ligand antagonist, follistatin 288 (FS288).	Heparitin Sulfate	29-31	transforming growth factor alpha	Homo sapiens	217-224
33176060-6	2021	Skeletal muscle myosin also reduced the inhibition of factor Xa and thrombin by antithrombin in the presence of heparan sulfate.	Heparitin Sulfate	112-127	coagulation factor X	Homo sapiens	54-63
33176060-6	2021	Skeletal muscle myosin also reduced the inhibition of factor Xa and thrombin by antithrombin in the presence of heparan sulfate.	Heparitin Sulfate	112-127	coagulation factor II, thrombin	Homo sapiens	68-76
33176060-6	2021	Skeletal muscle myosin also reduced the inhibition of factor Xa and thrombin by antithrombin in the presence of heparan sulfate.	Heparitin Sulfate	112-127	serpin family C member 1	Homo sapiens	80-92
33246160-2	2021	Syndecan-4 (Sdc4) is a heparan sulfate proteoglycan, expressed under inflammatory conditions and by chondrocytes during OA.	Heparitin Sulfate	23-38	syndecan 4	Homo sapiens	12-16
33420124-1	2021	Glypican-3 (GPC3) is a cell surface heparan sulfate proteoglycan that is being evaluated as an emerging therapeutic target in hepatocellular carcinoma (HCC).	Heparitin Sulfate	36-51	glypican 3	Homo sapiens	0-10
33572941-2	2021	IDUA catalyzes the degradation of the glycosaminoglycans dermatan and heparan sulfate (DS and HS, respectively).	Heparitin Sulfate	70-85	alpha-L-iduronidase	Homo sapiens	0-4
33514685-0	2021	Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection.	Heparitin Sulfate	21-36	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	13-18
33514685-0	2021	Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection.	Heparitin Sulfate	21-36	angiotensin converting enzyme 2	Homo sapiens	85-89
33318039-7	2021	Furthermore, co-localization studies showed that extracellular PKCdelta was anchored on the cell surface of liver cancer cells via association with Glypican 3, a liver cancer-related heparan sulfate proteoglycan.	Heparitin Sulfate	183-198	protein kinase C delta	Homo sapiens	63-71
33318039-7	2021	Furthermore, co-localization studies showed that extracellular PKCdelta was anchored on the cell surface of liver cancer cells via association with Glypican 3, a liver cancer-related heparan sulfate proteoglycan.	Heparitin Sulfate	183-198	glypican 3	Homo sapiens	148-158
33585253-0	2020	Elucidating the Consequences of Heparan Sulfate Binding by Heparanase 2.	Heparitin Sulfate	32-47	heparanase 2 (inactive)	Homo sapiens	59-71
33585253-3	2020	Hpa2 lacks the heparan sulfate (HS)-degrading activity typical of heparanase, yet exhibits high affinity to HS, affinity that is 10-fold higher than that of heparanase.	Heparitin Sulfate	15-30	heparanase 2 (inactive)	Homo sapiens	0-4
33585253-3	2020	Hpa2 lacks the heparan sulfate (HS)-degrading activity typical of heparanase, yet exhibits high affinity to HS, affinity that is 10-fold higher than that of heparanase.	Heparitin Sulfate	32-34	heparanase 2 (inactive)	Homo sapiens	0-4
33508266-8	2021	This gene encodes the heparan sulfate glucosamine 3-O-sulfotransferase 6 (3-OST-6) which is involved in the last step of heparan sulfate biosynthesis.	Heparitin Sulfate	22-37	heparan sulfate-glucosamine 3-sulfotransferase 6	Homo sapiens	74-81
33508266-10	2021	CONCLUSIONS: We conclude that mutant 3-OST-6 fails to transfer sulfo groups to the 3-OH position of heparan sulfate, resulting in incomplete heparan sulfate biosynthesis.	Heparitin Sulfate	100-115	heparan sulfate-glucosamine 3-sulfotransferase 6	Homo sapiens	37-44
33508266-10	2021	CONCLUSIONS: We conclude that mutant 3-OST-6 fails to transfer sulfo groups to the 3-OH position of heparan sulfate, resulting in incomplete heparan sulfate biosynthesis.	Heparitin Sulfate	141-156	heparan sulfate-glucosamine 3-sulfotransferase 6	Homo sapiens	37-44
33472641-6	2021	High sodium diet increased expression of nuclear factor of activated t-cells 5 (NFAT5)-a transcription factor responsive to changes in osmolarity-and moderately sulfated heparan sulfate in skin of healthy controls.	Heparitin Sulfate	170-185	nuclear factor of activated T cells 5	Homo sapiens	41-78
33472641-6	2021	High sodium diet increased expression of nuclear factor of activated t-cells 5 (NFAT5)-a transcription factor responsive to changes in osmolarity-and moderately sulfated heparan sulfate in skin of healthy controls.	Heparitin Sulfate	170-185	nuclear factor of activated T cells 5	Homo sapiens	80-85
33173010-4	2021	In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells.	Heparitin Sulfate	167-182	angiotensin converting enzyme 2	Homo sapiens	72-103
33173010-4	2021	In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells.	Heparitin Sulfate	167-182	angiotensin converting enzyme 2	Homo sapiens	105-110
33420239-1	2021	Sulf2a belongs to the Sulf family of extracellular sulfatases which selectively remove 6-O-sulfate groups from heparan sulfates, a critical regulation level for their role in modulating the activity of signalling molecules.	Heparitin Sulfate	111-127	sulfatase 2a	Danio rerio	0-6
33420124-1	2021	Glypican-3 (GPC3) is a cell surface heparan sulfate proteoglycan that is being evaluated as an emerging therapeutic target in hepatocellular carcinoma (HCC).	Heparitin Sulfate	36-51	glypican 3	Homo sapiens	12-16
33403386-8	2021	When HS release from Gpc-1 was enhanced by ascorbate in ApoE4/4 fibroblasts, there was efficient transfer of Abeta and HS from the nuclei to autophagosomes.	Heparitin Sulfate	5-7	glypican 1	Homo sapiens	21-26
33436043-0	2021	The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma.	Heparitin Sulfate	41-56	C-X-C motif chemokine ligand 12	Homo sapiens	4-15
33436043-3	2021	The gamma isoform of CXCL12 (CXCL12gamma) has been reported to be highly expressed in mouse BM and to show enhanced biological activity compared to the "common" CXCL12alpha isoform, mediated by its unique extended C-terminal domain, which binds heparan sulfate proteoglycans (HSPGs) with an extraordinary high affinity.	Heparitin Sulfate	245-260	chemokine (C-X-C motif) ligand 12	Mus musculus	21-27
33436043-3	2021	The gamma isoform of CXCL12 (CXCL12gamma) has been reported to be highly expressed in mouse BM and to show enhanced biological activity compared to the "common" CXCL12alpha isoform, mediated by its unique extended C-terminal domain, which binds heparan sulfate proteoglycans (HSPGs) with an extraordinary high affinity.	Heparitin Sulfate	245-260	chemokine (C-X-C motif) ligand 12	Mus musculus	29-40
33436043-6	2021	CRISPR-Cas9 was employed to delete CXCL12gamma and the heparan sulfate (HS) co-polymerase EXT1 in BMSCs.	Heparitin Sulfate	55-70	exostosin glycosyltransferase 1	Homo sapiens	90-94
33403386-8	2021	When HS release from Gpc-1 was enhanced by ascorbate in ApoE4/4 fibroblasts, there was efficient transfer of Abeta and HS from the nuclei to autophagosomes.	Heparitin Sulfate	5-7	apolipoprotein E	Homo sapiens	56-61
33403386-0	2021	Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1.	Heparitin Sulfate	133-148	apolipoprotein E	Homo sapiens	12-29
33403386-8	2021	When HS release from Gpc-1 was enhanced by ascorbate in ApoE4/4 fibroblasts, there was efficient transfer of Abeta and HS from the nuclei to autophagosomes.	Heparitin Sulfate	5-7	amyloid beta precursor protein	Homo sapiens	109-114
33403386-0	2021	Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1.	Heparitin Sulfate	133-148	glypican 1	Homo sapiens	154-164
33403386-8	2021	When HS release from Gpc-1 was enhanced by ascorbate in ApoE4/4 fibroblasts, there was efficient transfer of Abeta and HS from the nuclei to autophagosomes.	Heparitin Sulfate	119-121	glypican 1	Homo sapiens	21-26
33403386-3	2021	The amyloid precursor protein (APP) and the heparan sulfate (HS)-containing proteoglycan glypican-1 (Gpc-1) are both processed in endosomes, and mutually regulated by the APP degradation products and the released HS.	Heparitin Sulfate	44-59	glypican 1	Homo sapiens	89-99
33403386-3	2021	The amyloid precursor protein (APP) and the heparan sulfate (HS)-containing proteoglycan glypican-1 (Gpc-1) are both processed in endosomes, and mutually regulated by the APP degradation products and the released HS.	Heparitin Sulfate	44-59	glypican 1	Homo sapiens	101-106
33403386-8	2021	When HS release from Gpc-1 was enhanced by ascorbate in ApoE4/4 fibroblasts, there was efficient transfer of Abeta and HS from the nuclei to autophagosomes.	Heparitin Sulfate	119-121	apolipoprotein E	Homo sapiens	56-61
32390181-7	2021	In experiments with heterologously expressed protein, the extracellular domain of LRRTM4 was found to engage in heparan-sulfate dependent binding with pikachurin.	Heparitin Sulfate	112-127	leucine rich repeat transmembrane neuronal 4	Homo sapiens	82-88
33185156-1	2021	BACKGROUND: An endo-beta-glucuronidase enzyme, Heparanase (HPSE) degrades the side chains of polymeric heparan sulfate (HS), a glycosaminoglycan formed by alternate repetitive units of D-glucosamine and D-glucuronic acid/L-iduronic acid.	Heparitin Sulfate	103-118	heparanase	Homo sapiens	47-57
33185156-1	2021	BACKGROUND: An endo-beta-glucuronidase enzyme, Heparanase (HPSE) degrades the side chains of polymeric heparan sulfate (HS), a glycosaminoglycan formed by alternate repetitive units of D-glucosamine and D-glucuronic acid/L-iduronic acid.	Heparitin Sulfate	103-118	heparanase	Homo sapiens	59-63
33185156-1	2021	BACKGROUND: An endo-beta-glucuronidase enzyme, Heparanase (HPSE) degrades the side chains of polymeric heparan sulfate (HS), a glycosaminoglycan formed by alternate repetitive units of D-glucosamine and D-glucuronic acid/L-iduronic acid.	Heparitin Sulfate	120-122	heparanase	Homo sapiens	47-57
33185156-1	2021	BACKGROUND: An endo-beta-glucuronidase enzyme, Heparanase (HPSE) degrades the side chains of polymeric heparan sulfate (HS), a glycosaminoglycan formed by alternate repetitive units of D-glucosamine and D-glucuronic acid/L-iduronic acid.	Heparitin Sulfate	120-122	heparanase	Homo sapiens	59-63
33185156-3	2021	The degradation of HS by HPSE enzyme leads to the conditions like inflammation, angiogenesis, and metastasis.	Heparitin Sulfate	19-21	heparanase	Homo sapiens	25-29
32367652-0	2021	The heparan sulfate proteoglycan Syndecan-1 regulates colon cancer stem cell function via a focal adhesion kinase - Wnt signaling axis.	Heparitin Sulfate	4-19	syndecan 1	Homo sapiens	33-43
32367652-0	2021	The heparan sulfate proteoglycan Syndecan-1 regulates colon cancer stem cell function via a focal adhesion kinase - Wnt signaling axis.	Heparitin Sulfate	4-19	protein tyrosine kinase 2	Homo sapiens	92-113
32367652-1	2021	In colon cancer, downregulation of the transmembrane heparan sulfate proteoglycan Syndecan-1 is associated with increased invasiveness, metastasis and dedifferentiation.	Heparitin Sulfate	53-68	syndecan 1	Homo sapiens	82-92
33129446-3	2021	Both heparin (HP) and heparan sulfate (HS) bind to the N-lobe domain of hLF.	Heparitin Sulfate	22-37	HLF transcription factor, PAR bZIP family member	Homo sapiens	72-75
33129446-3	2021	Both heparin (HP) and heparan sulfate (HS) bind to the N-lobe domain of hLF.	Heparitin Sulfate	39-41	HLF transcription factor, PAR bZIP family member	Homo sapiens	72-75
33968333-7	2021	Docking studies using GlycoTorch Vina and subsequent MD simulations of the spike trimer in the presence of dodecasaccharides of the GAGs heparin and heparan sulfate supported this possibility.	Heparitin Sulfate	149-164	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	75-80
33968333-10	2021	These findings identify a site in the spike protein that favors heparan sulfate binding that may be particularly pertinent for a better understanding of the recent UK and South African strains.	Heparitin Sulfate	64-79	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	38-43
33271281-5	2021	MPO binding to GLX of human ECs and subsequent internalization was mediated by cell surface heparan sulfate chains.	Heparitin Sulfate	92-107	myeloperoxidase	Homo sapiens	0-3
33402482-1	2021	BACKGROUND/AIM: The mechanisms underlying the contribution of the heparan sulfate proteoglycan syndecan-1 to liver tissue injury and to crucial biological processes, such as fibrogenesis, remain to be elucidated.	Heparitin Sulfate	66-81	syndecan 1	Homo sapiens	95-105
32390181-7	2021	In experiments with heterologously expressed protein, the extracellular domain of LRRTM4 was found to engage in heparan-sulfate dependent binding with pikachurin.	Heparitin Sulfate	112-127	EGF like, fibronectin type III and laminin G domains	Homo sapiens	151-161
33319323-1	2021	Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease caused by a mutation in the IDUA gene, which codes alpha-L-iduronidase (IDUA), a lysosomal hydrolase that degrades two glycosaminoglycans (GAGs): heparan sulfate (HS) and dermatan sulfate (DS).	Heparitin Sulfate	214-229	iduronidase, alpha-L	Mus musculus	96-100
33028660-0	2021	Heparan sulfate synthesized by Ext1 regulates receptor tyrosine kinase signaling and promotes resistance to EGFR inhibitors in GBM.	Heparitin Sulfate	0-15	exostosin glycosyltransferase 1	Homo sapiens	31-35
33028660-0	2021	Heparan sulfate synthesized by Ext1 regulates receptor tyrosine kinase signaling and promotes resistance to EGFR inhibitors in GBM.	Heparitin Sulfate	0-15	ret proto-oncogene	Homo sapiens	46-70
33028660-0	2021	Heparan sulfate synthesized by Ext1 regulates receptor tyrosine kinase signaling and promotes resistance to EGFR inhibitors in GBM.	Heparitin Sulfate	0-15	epidermal growth factor receptor	Homo sapiens	108-112
33319323-1	2021	Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease caused by a mutation in the IDUA gene, which codes alpha-L-iduronidase (IDUA), a lysosomal hydrolase that degrades two glycosaminoglycans (GAGs): heparan sulfate (HS) and dermatan sulfate (DS).	Heparitin Sulfate	214-229	iduronidase, alpha-L	Mus musculus	140-144
33319323-1	2021	Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease caused by a mutation in the IDUA gene, which codes alpha-L-iduronidase (IDUA), a lysosomal hydrolase that degrades two glycosaminoglycans (GAGs): heparan sulfate (HS) and dermatan sulfate (DS).	Heparitin Sulfate	231-233	iduronidase, alpha-L	Mus musculus	96-100
33319323-1	2021	Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease caused by a mutation in the IDUA gene, which codes alpha-L-iduronidase (IDUA), a lysosomal hydrolase that degrades two glycosaminoglycans (GAGs): heparan sulfate (HS) and dermatan sulfate (DS).	Heparitin Sulfate	231-233	iduronidase, alpha-L	Mus musculus	140-144
33414810-2	2020	In most cases, EXT1 and EXT2, which encode glycosyltransferases involved in the biosynthesis of heparan sulfate, are the genes responsible.	Heparitin Sulfate	96-111	exostosin glycosyltransferase 1	Homo sapiens	15-19
33414810-2	2020	In most cases, EXT1 and EXT2, which encode glycosyltransferases involved in the biosynthesis of heparan sulfate, are the genes responsible.	Heparitin Sulfate	96-111	exostosin glycosyltransferase 2	Homo sapiens	24-28
33355559-4	2020	Our results also revealed that higher affinity to heparan sulfate of the rigid stapled Tat peptides correlated well with the higher cellular uptake compared with non-stapled Tat peptides with flexible charge display.	Heparitin Sulfate	50-65	tyrosine aminotransferase	Homo sapiens	87-90
33355559-4	2020	Our results also revealed that higher affinity to heparan sulfate of the rigid stapled Tat peptides correlated well with the higher cellular uptake compared with non-stapled Tat peptides with flexible charge display.	Heparitin Sulfate	50-65	tyrosine aminotransferase	Homo sapiens	174-177
33333756-3	2020	This study aimed to elucidate the role of heparan sulfate integrin interaction and downstream kinase phosphorylation for HIF-1alpha stabilisation under compressive and tensile strain and to which extent downstream synthesis of VEGF and prostaglandins is HIF-1alpha-dependent in a model of simulated OTM in PDLF.	Heparitin Sulfate	42-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-131
33326477-0	2020	Correction: Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice.	Heparitin Sulfate	74-89	vascular endothelial growth factor A	Mus musculus	39-43
33333756-3	2020	This study aimed to elucidate the role of heparan sulfate integrin interaction and downstream kinase phosphorylation for HIF-1alpha stabilisation under compressive and tensile strain and to which extent downstream synthesis of VEGF and prostaglandins is HIF-1alpha-dependent in a model of simulated OTM in PDLF.	Heparitin Sulfate	42-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	254-264
33302918-1	2020	BACKGROUND: Glypican-1 is a heparan sulfate proteoglycan that is overexpressed in prostate cancer (PCa), and a variety of solid tumors.	Heparitin Sulfate	28-43	glypican 1	Homo sapiens	12-22
33381505-3	2020	In this study, we used heparan sulfate (HS), which is a highly acidic linear polysaccharide with a highly variable structure, to mimic the negative charges of the extracellular microenvironment and detected the adhesive behaviors of integrin alpha4beta7 expressing 293T cells to immobilized MAdCAM-1 in vitro.	Heparitin Sulfate	23-38	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	291-299
33381505-3	2020	In this study, we used heparan sulfate (HS), which is a highly acidic linear polysaccharide with a highly variable structure, to mimic the negative charges of the extracellular microenvironment and detected the adhesive behaviors of integrin alpha4beta7 expressing 293T cells to immobilized MAdCAM-1 in vitro.	Heparitin Sulfate	40-42	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	291-299
32810562-6	2020	To confirm the importance of HS in vivo, we deleted Ext1, which encodes an enzyme essential for HS biosynthesis, specifically in the mouse skeletal muscles (referred to as mExt1CKO mice).	Heparitin Sulfate	96-98	exostosin glycosyltransferase 1	Mus musculus	52-56
33159882-2	2020	Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) is one of several specialized enzymes required for heparan sulfate synthesis and catalyzes the transfer of the sulfate groups to the sugar moiety of heparan sulfate.	Heparitin Sulfate	99-114	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	0-38
33159882-2	2020	Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) is one of several specialized enzymes required for heparan sulfate synthesis and catalyzes the transfer of the sulfate groups to the sugar moiety of heparan sulfate.	Heparitin Sulfate	99-114	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	40-46
33159882-2	2020	Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) is one of several specialized enzymes required for heparan sulfate synthesis and catalyzes the transfer of the sulfate groups to the sugar moiety of heparan sulfate.	Heparitin Sulfate	197-212	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	0-38
33159882-2	2020	Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) is one of several specialized enzymes required for heparan sulfate synthesis and catalyzes the transfer of the sulfate groups to the sugar moiety of heparan sulfate.	Heparitin Sulfate	197-212	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	40-46
33159882-6	2020	The heparan sulfate synthesized by the individual 1 cell line lacks 2-O-sulfated domains but had an increase in N- and 6-O-sulfated domains demonstrating functional impairment of the HS2ST1.	Heparitin Sulfate	4-19	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	183-189
33159882-7	2020	As heparan sulfate modulates FGF-mediated signaling, we found a significantly decreased activation of the MAP kinases ERK1/2 in FGF-2-stimulated cell lines of affected individuals that could be restored by addition of heparin, a GAG similar to heparan sulfate.	Heparitin Sulfate	3-18	fibroblast growth factor 2	Homo sapiens	29-32
33159882-7	2020	As heparan sulfate modulates FGF-mediated signaling, we found a significantly decreased activation of the MAP kinases ERK1/2 in FGF-2-stimulated cell lines of affected individuals that could be restored by addition of heparin, a GAG similar to heparan sulfate.	Heparitin Sulfate	3-18	mitogen-activated protein kinase 3	Homo sapiens	118-124
33159882-7	2020	As heparan sulfate modulates FGF-mediated signaling, we found a significantly decreased activation of the MAP kinases ERK1/2 in FGF-2-stimulated cell lines of affected individuals that could be restored by addition of heparin, a GAG similar to heparan sulfate.	Heparitin Sulfate	3-18	fibroblast growth factor 2	Homo sapiens	128-133
33159882-7	2020	As heparan sulfate modulates FGF-mediated signaling, we found a significantly decreased activation of the MAP kinases ERK1/2 in FGF-2-stimulated cell lines of affected individuals that could be restored by addition of heparin, a GAG similar to heparan sulfate.	Heparitin Sulfate	244-259	fibroblast growth factor 2	Homo sapiens	29-32
33159882-7	2020	As heparan sulfate modulates FGF-mediated signaling, we found a significantly decreased activation of the MAP kinases ERK1/2 in FGF-2-stimulated cell lines of affected individuals that could be restored by addition of heparin, a GAG similar to heparan sulfate.	Heparitin Sulfate	244-259	mitogen-activated protein kinase 3	Homo sapiens	118-124
33159882-7	2020	As heparan sulfate modulates FGF-mediated signaling, we found a significantly decreased activation of the MAP kinases ERK1/2 in FGF-2-stimulated cell lines of affected individuals that could be restored by addition of heparin, a GAG similar to heparan sulfate.	Heparitin Sulfate	244-259	fibroblast growth factor 2	Homo sapiens	128-133
32928959-8	2020	The interaction of N-MADD-4B with NLG-1 is also disrupted by heparin, used as a surrogate for the extracellular matrix component, heparan sulphate, and whose high-affinity binding to the Ig-like domain may proceed from surface charge complementarity, as suggested by homology 3D modelling.	Heparitin Sulfate	130-146	COesterase domain-containing protein;Neuroligin-1	Caenorhabditis elegans	34-39
32998001-0	2020	Heparan sulfate binds the extracellular Annexin A1 and blocks its effects on pancreatic cancer cells.	Heparitin Sulfate	0-15	annexin A1	Homo sapiens	40-50
32976972-7	2020	Enzymic digestion by cell surface heparin/heparan sulfate using heparinase I, II, and III could significantly prevent TFV attachment, suggesting that heparan sulfate plays an important role in TFV attachment.	Heparitin Sulfate	42-57	heparinase i, ii, and iii	None	64-89
32976972-7	2020	Enzymic digestion by cell surface heparin/heparan sulfate using heparinase I, II, and III could significantly prevent TFV attachment, suggesting that heparan sulfate plays an important role in TFV attachment.	Heparitin Sulfate	150-165	heparinase i, ii, and iii	None	64-89
33256730-1	2020	Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix.	Heparitin Sulfate	53-69	heparanase	Homo sapiens	0-10
32623935-2	2020	An important feature of syndecan-1 related to its role in pathologies is that it can be shed from the surface of cells as an intact ectodomain composed of the extracellular core protein and attached heparan sulfate and chondroitin sulfate chains.	Heparitin Sulfate	199-214	syndecan 1	Homo sapiens	24-34
32623935-5	2020	The accessibility of these proteases to the core protein of syndecan-1 is enhanced, and shedding facilitated, when the heparan sulfate chains of syndecan-1 have been shortened by the enzymatic activity of heparanase.	Heparitin Sulfate	119-134	syndecan 1	Homo sapiens	60-70
32623935-5	2020	The accessibility of these proteases to the core protein of syndecan-1 is enhanced, and shedding facilitated, when the heparan sulfate chains of syndecan-1 have been shortened by the enzymatic activity of heparanase.	Heparitin Sulfate	119-134	syndecan 1	Homo sapiens	145-155
32623935-5	2020	The accessibility of these proteases to the core protein of syndecan-1 is enhanced, and shedding facilitated, when the heparan sulfate chains of syndecan-1 have been shortened by the enzymatic activity of heparanase.	Heparitin Sulfate	119-134	heparanase	Homo sapiens	205-215
33239699-0	2020	The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis.	Heparitin Sulfate	4-19	syndecan 1	Mus musculus	33-43
33239699-0	2020	The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis.	Heparitin Sulfate	4-19	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	93-98
33239699-0	2020	The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis.	Heparitin Sulfate	4-19	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	99-102
33239699-1	2020	The heparan sulfate proteoglycan Syndecan-1, a mediator of signals between the extracellular matrix and cells involved is able to interact with OPG, one of the major regulators of osteoclastogenesis.	Heparitin Sulfate	4-19	syndecan 1	Mus musculus	33-43
33239699-1	2020	The heparan sulfate proteoglycan Syndecan-1, a mediator of signals between the extracellular matrix and cells involved is able to interact with OPG, one of the major regulators of osteoclastogenesis.	Heparitin Sulfate	4-19	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	144-147
33146178-0	2020	Visualizing antithrombin-binding 3-O-sulfated heparan sulfate motifs on cell surfaces.	Heparitin Sulfate	46-61	serpin family C member 1	Homo sapiens	12-24
33230178-1	2020	Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome B) is an autosomal recessive lysosomal storage disorder caused by the deficiency of alpha-N-acetylglucosaminidase activity, leading to increased levels of nondegraded heparan sulfate (HS).	Heparitin Sulfate	230-245	N-acetyl-alpha-glucosaminidase	Canis lupus familiaris	147-176
33146178-1	2020	To map the cellular topography of the rare 3-O-sulfated structural motif of heparan sulfate (HS), we constructed quantum dot-based probes for antithrombin and FGF2, which reveal widely different distribution of the targeted HS motifs.	Heparitin Sulfate	76-91	fibroblast growth factor 2	Homo sapiens	159-163
33146178-1	2020	To map the cellular topography of the rare 3-O-sulfated structural motif of heparan sulfate (HS), we constructed quantum dot-based probes for antithrombin and FGF2, which reveal widely different distribution of the targeted HS motifs.	Heparitin Sulfate	93-95	serpin family C member 1	Homo sapiens	142-154
33146178-1	2020	To map the cellular topography of the rare 3-O-sulfated structural motif of heparan sulfate (HS), we constructed quantum dot-based probes for antithrombin and FGF2, which reveal widely different distribution of the targeted HS motifs.	Heparitin Sulfate	93-95	fibroblast growth factor 2	Homo sapiens	159-163
32629061-5	2020	Mechanistically, copper/iron ions enhanced alpha-synuclein fibrils internalization was mediated by negatively charged membrane heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	127-142	synuclein alpha	Homo sapiens	43-58
33214666-4	2020	In myeloid precursors, the granulocyte-macrophage progenitors (GMPs), loss of NSP4 results in the decrease of cellular levels of histamine, serotonin and heparin/heparan sulfate.	Heparitin Sulfate	162-177	protease, serine 57	Mus musculus	78-82
32970989-1	2020	We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD).	Heparitin Sulfate	67-82	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	24-29
32970989-2	2020	Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site.	Heparitin Sulfate	34-49	angiotensin converting enzyme 2	Homo sapiens	79-83
32970989-5	2020	On cells, spike protein binding depends on both heparan sulfate and ACE2.	Heparitin Sulfate	48-63	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	10-15
32970989-6	2020	Unfractionated heparin, non-anticoagulant heparin, heparin lyases, and lung heparan sulfate potently block spike protein binding and/or infection by pseudotyped virus and authentic SARS-CoV-2 virus.	Heparitin Sulfate	76-91	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	107-112
32970989-7	2020	We suggest a model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2.	Heparitin Sulfate	68-83	angiotensin converting enzyme 2	Homo sapiens	120-124
32860852-7	2020	VEGF was found to interact with heparan sulfate proteoglycans on the CAF sEV surface and could be released by heparinase I/III.	Heparitin Sulfate	32-47	vascular endothelial growth factor A	Homo sapiens	0-4
33154448-1	2020	Heparan sulfate (HS) chains, covalently linked to heparan sulfate proteoglycans (HSPG), promote synaptic development and functions by connecting various synaptic adhesion proteins (AP).	Heparitin Sulfate	0-15	syndecan 2	Mus musculus	81-85
33154448-1	2020	Heparan sulfate (HS) chains, covalently linked to heparan sulfate proteoglycans (HSPG), promote synaptic development and functions by connecting various synaptic adhesion proteins (AP).	Heparitin Sulfate	17-19	syndecan 2	Mus musculus	81-85
33154448-1	2020	Heparan sulfate (HS) chains, covalently linked to heparan sulfate proteoglycans (HSPG), promote synaptic development and functions by connecting various synaptic adhesion proteins (AP).	Heparitin Sulfate	50-65	syndecan 2	Mus musculus	81-85
33298900-2	2020	Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry.	Heparitin Sulfate	139-154	angiotensin converting enzyme 2	Homo sapiens	71-75
33298900-2	2020	Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry.	Heparitin Sulfate	139-154	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	283-288
33298900-2	2020	Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry.	Heparitin Sulfate	156-158	angiotensin converting enzyme 2	Homo sapiens	71-75
33298900-2	2020	Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry.	Heparitin Sulfate	156-158	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	283-288
33298900-3	2020	We show that heparin/HS binds to Spike directly, and facilitates the attachment of Spike-bearing viral particles to the cell surface to promote viral entry.	Heparitin Sulfate	21-23	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	33-38
33298900-3	2020	We show that heparin/HS binds to Spike directly, and facilitates the attachment of Spike-bearing viral particles to the cell surface to promote viral entry.	Heparitin Sulfate	21-23	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	83-88
33196458-0	2020	Drug-selected population in melanoma A2058 cells as melanoma stem-like cells retained angiogenic features - the potential roles of heparan-sulfate binding ANGPTL4 protein.	Heparitin Sulfate	131-146	angiopoietin like 4	Homo sapiens	155-162
33294792-4	2020	Besides, we found that treatment with Syndecan-1, a heparan sulfate proteoglycan involved in NSC proliferation, hastened the division of qNSCs and increased proliferation of aNSCs shortening their G1 phase in vitro.	Heparitin Sulfate	52-67	syndecan 1	Mus musculus	38-48
32731916-4	2020	ECM is composed of diverse components including several proteins and polysaccharide chains such as chondroitin sulfate, heparan sulfate, and hyaluronic acid.	Heparitin Sulfate	120-135	multimerin 1	Homo sapiens	0-3
32927086-14	2020	SDC4 silencing cells are more dependent of growth factors present in the FCS to synthesize heparan sulfate than parental cells.	Heparitin Sulfate	91-106	syndecan 4	Homo sapiens	0-4
32711078-9	2020	Docking studies in P32 protein of SPPV and GTPV revealed conserved binding pattern with heparan sulfate which is involved in the virus attachment and varied glycosyltransferase fold with UDP-glucose.	Heparitin Sulfate	88-103	complement C1q binding protein	Homo sapiens	19-22
32818603-1	2020	OBJECTIVE: Exostosin-1 (EXT1) and EXT2 are the major genetic etiologies of multiple hereditary exostoses and are essential for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	127-142	exostosin glycosyltransferase 1	Mus musculus	11-22
32818603-1	2020	OBJECTIVE: Exostosin-1 (EXT1) and EXT2 are the major genetic etiologies of multiple hereditary exostoses and are essential for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	127-142	exostosin glycosyltransferase 1	Mus musculus	24-28
32818603-1	2020	OBJECTIVE: Exostosin-1 (EXT1) and EXT2 are the major genetic etiologies of multiple hereditary exostoses and are essential for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	127-142	exostosin glycosyltransferase 2	Mus musculus	34-38
32818603-1	2020	OBJECTIVE: Exostosin-1 (EXT1) and EXT2 are the major genetic etiologies of multiple hereditary exostoses and are essential for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	144-146	exostosin glycosyltransferase 1	Mus musculus	11-22
32818603-1	2020	OBJECTIVE: Exostosin-1 (EXT1) and EXT2 are the major genetic etiologies of multiple hereditary exostoses and are essential for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	144-146	exostosin glycosyltransferase 1	Mus musculus	24-28
32818603-1	2020	OBJECTIVE: Exostosin-1 (EXT1) and EXT2 are the major genetic etiologies of multiple hereditary exostoses and are essential for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	144-146	exostosin glycosyltransferase 2	Mus musculus	34-38
33037075-4	2020	In addition, Nrxn1alpha showed robust heparan sulfate (HS)-dependent, high-affinity interactions with Ig domains of PTPsigma that were regulated by the splicing status of PTPsigma.	Heparitin Sulfate	38-53	protein tyrosine phosphatase, receptor type, S	Mus musculus	116-124
33065549-1	2020	We previously reported that binding to heparan sulfate (HS) is required for the ability of the placentally secreted pregnancy-specific glycoprotein 1 (PSG1) to induce endothelial tubulogenesis.	Heparitin Sulfate	39-54	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	116-149
33065549-1	2020	We previously reported that binding to heparan sulfate (HS) is required for the ability of the placentally secreted pregnancy-specific glycoprotein 1 (PSG1) to induce endothelial tubulogenesis.	Heparitin Sulfate	39-54	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	151-155
33065549-1	2020	We previously reported that binding to heparan sulfate (HS) is required for the ability of the placentally secreted pregnancy-specific glycoprotein 1 (PSG1) to induce endothelial tubulogenesis.	Heparitin Sulfate	56-58	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	116-149
33065549-1	2020	We previously reported that binding to heparan sulfate (HS) is required for the ability of the placentally secreted pregnancy-specific glycoprotein 1 (PSG1) to induce endothelial tubulogenesis.	Heparitin Sulfate	56-58	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	151-155
33037075-4	2020	In addition, Nrxn1alpha showed robust heparan sulfate (HS)-dependent, high-affinity interactions with Ig domains of PTPsigma that were regulated by the splicing status of PTPsigma.	Heparitin Sulfate	38-53	protein tyrosine phosphatase, receptor type, S	Mus musculus	171-179
33037075-4	2020	In addition, Nrxn1alpha showed robust heparan sulfate (HS)-dependent, high-affinity interactions with Ig domains of PTPsigma that were regulated by the splicing status of PTPsigma.	Heparitin Sulfate	55-57	protein tyrosine phosphatase, receptor type, S	Mus musculus	116-124
33037075-4	2020	In addition, Nrxn1alpha showed robust heparan sulfate (HS)-dependent, high-affinity interactions with Ig domains of PTPsigma that were regulated by the splicing status of PTPsigma.	Heparitin Sulfate	55-57	protein tyrosine phosphatase, receptor type, S	Mus musculus	171-179
33178691-3	2020	Here we demonstrate that silencing of syndecan-4, a transmembrane heparan sulfate proteoglycan, interferes with the correct polarization of migrating mammalian myoblasts (i.e., activated satellite stem cells).	Heparitin Sulfate	66-81	syndecan 4	Homo sapiens	38-48
32771510-0	2020	Selective regulation of RANKL/RANK/OPG pathway by heparan sulfate through the binding with estrogen receptor beta in MC3T3-E1 cells.	Heparitin Sulfate	50-65	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	24-29
32771510-0	2020	Selective regulation of RANKL/RANK/OPG pathway by heparan sulfate through the binding with estrogen receptor beta in MC3T3-E1 cells.	Heparitin Sulfate	50-65	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	35-38
32771510-0	2020	Selective regulation of RANKL/RANK/OPG pathway by heparan sulfate through the binding with estrogen receptor beta in MC3T3-E1 cells.	Heparitin Sulfate	50-65	estrogen receptor 1 (alpha)	Mus musculus	91-113
32771510-1	2020	Heparan sulfate (HS) is a linear anionic polysaccharide with repeating sulfated disaccharide units, which has been proven with various regulatory osteogenesis effects through multi-pathway signaling, but its impacts on receptor-activator of nuclear factor kappa beta ligand/receptor-activator of nuclear factor kappa beta/osteoprotegerin (RANKL/RANK/OPG) pathway is still poorly understood.	Heparitin Sulfate	0-15	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	322-337
32771510-1	2020	Heparan sulfate (HS) is a linear anionic polysaccharide with repeating sulfated disaccharide units, which has been proven with various regulatory osteogenesis effects through multi-pathway signaling, but its impacts on receptor-activator of nuclear factor kappa beta ligand/receptor-activator of nuclear factor kappa beta/osteoprotegerin (RANKL/RANK/OPG) pathway is still poorly understood.	Heparitin Sulfate	0-15	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	339-344
32771510-1	2020	Heparan sulfate (HS) is a linear anionic polysaccharide with repeating sulfated disaccharide units, which has been proven with various regulatory osteogenesis effects through multi-pathway signaling, but its impacts on receptor-activator of nuclear factor kappa beta ligand/receptor-activator of nuclear factor kappa beta/osteoprotegerin (RANKL/RANK/OPG) pathway is still poorly understood.	Heparitin Sulfate	0-15	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	350-353
32991636-5	2020	Molecular docking simulations confirmed enhanced binding of heparan sulphate to a model of the adapted SAT1 virus, with the region around VP1 arginine 112 contributing the most to binding.	Heparitin Sulfate	60-76	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	103-107
33021626-0	2021	Structure, Dynamics, and Interactions of GPI-Anchored Human Glypican-1 with Heparan Sulfates in a Membrane.	Heparitin Sulfate	76-92	glypican 1	Homo sapiens	60-70
33021626-1	2021	Glypican-1 and its heparan sulfate (HS) chains play important roles in modulating many biological processes including growth factor signaling.	Heparitin Sulfate	19-34	glypican 1	Homo sapiens	0-10
33021626-1	2021	Glypican-1 and its heparan sulfate (HS) chains play important roles in modulating many biological processes including growth factor signaling.	Heparitin Sulfate	36-38	glypican 1	Homo sapiens	0-10
32822214-5	2020	Furthermore, we showed by real-time PCR that this dimension modification of endothelial glycocalyx may be attributed to a significant downregulation of heparan sulfate proteoglycan (HSPG)-related genes, including syndecan-3, glypican-1, and EXT1, not resulting from an enhanced shedding of sulfated glycosaminoglycans (sGAGs) from the vessel wall to the plasma.	Heparitin Sulfate	152-167	syndecan 3	Rattus norvegicus	213-223
32822214-5	2020	Furthermore, we showed by real-time PCR that this dimension modification of endothelial glycocalyx may be attributed to a significant downregulation of heparan sulfate proteoglycan (HSPG)-related genes, including syndecan-3, glypican-1, and EXT1, not resulting from an enhanced shedding of sulfated glycosaminoglycans (sGAGs) from the vessel wall to the plasma.	Heparitin Sulfate	152-167	glypican 1	Rattus norvegicus	225-235
32822214-5	2020	Furthermore, we showed by real-time PCR that this dimension modification of endothelial glycocalyx may be attributed to a significant downregulation of heparan sulfate proteoglycan (HSPG)-related genes, including syndecan-3, glypican-1, and EXT1, not resulting from an enhanced shedding of sulfated glycosaminoglycans (sGAGs) from the vessel wall to the plasma.	Heparitin Sulfate	152-167	exostosin glycosyltransferase 1	Rattus norvegicus	241-245
32945393-4	2020	Heparanase (Hpa), the only mammalian endoglycosidase that cleaves heparan sulfate, has been demonstrated to contribute to the growth, angiogenesis and metastasis of numerous cancers.	Heparitin Sulfate	66-81	heparanase	Homo sapiens	0-10
32945393-4	2020	Heparanase (Hpa), the only mammalian endoglycosidase that cleaves heparan sulfate, has been demonstrated to contribute to the growth, angiogenesis and metastasis of numerous cancers.	Heparitin Sulfate	66-81	heparanase	Homo sapiens	12-15
33050843-0	2022	Investigating the pernicious effects of heparan sulfate in serum amyloid A1 protein aggregation: a structural bioinformatics approach.	Heparitin Sulfate	40-55	serum amyloid A1	Homo sapiens	59-75
33050843-4	2022	Recent experimental findings insinuate that heparan sulphate (HS), a glycosaminoglycans, exhibits binding with SAA1 to promote its aggregation.	Heparitin Sulfate	44-60	serum amyloid A1	Homo sapiens	111-115
33050843-4	2022	Recent experimental findings insinuate that heparan sulphate (HS), a glycosaminoglycans, exhibits binding with SAA1 to promote its aggregation.	Heparitin Sulfate	62-64	serum amyloid A1	Homo sapiens	111-115
33050843-12	2022	In conclusion, the aforementioned conformational ramifications induced by HS on SAA1 could potentially be the proteopathic incendiary behind AA amyloidosis; this incendiary will need to be considered in future studies for developing effective therapeutics against AA amyloidosis.	Heparitin Sulfate	74-76	serum amyloid A1	Homo sapiens	80-84
32483835-5	2020	We find that soluble heparin and heparan sulfate efficiently inhibit human IL-27 activity as shown by decreased STAT signaling and downstream biological effects.	Heparitin Sulfate	33-48	interleukin 27	Homo sapiens	75-80
32483835-6	2020	In contrast, membrane-bound heparan sulfate seems to positively regulate IL-27 activity.	Heparitin Sulfate	28-43	interleukin 27	Homo sapiens	73-78
32673751-0	2020	Heparan sulfate co-immobilized with cRGD ligands and BMP2 on biomimetic platforms promotes BMP2-mediated osteogenic differentiation.	Heparitin Sulfate	0-15	bone morphogenetic protein 2	Homo sapiens	91-95
32977498-1	2020	Syndecan-1 is a transmembrane heparan sulfate proteoglycan which is indispensable in the structural and functional integrity of epithelia.	Heparitin Sulfate	30-45	syndecan 1	Homo sapiens	0-10
32977498-4	2020	Furthermore, overexpression of syndecan-1 in hepatoma cells is associated with a shift of heparan sulfate structure toward a highly sulfated type specific for normal liver.	Heparitin Sulfate	90-105	syndecan 1	Homo sapiens	31-41
32977498-8	2020	Accordingly, a reporter gene assay revealed the inhibition of Ets-1 as well as AP-1 transcription factor-induced promoter activation, presumably an effect of the heparan sulfate switch.	Heparitin Sulfate	162-177	ETS proto-oncogene 1, transcription factor	Homo sapiens	62-67
32977498-8	2020	Accordingly, a reporter gene assay revealed the inhibition of Ets-1 as well as AP-1 transcription factor-induced promoter activation, presumably an effect of the heparan sulfate switch.	Heparitin Sulfate	162-177	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-83
32673751-8	2020	Altogether, our results show that HS facilitated and sustained the synergy between BMP2 and integrin pathways and that the co-immobilization of HS and cRGD peptides optimised BMP2-mediated osteogenic differentiation.	Heparitin Sulfate	144-146	bone morphogenetic protein 2	Homo sapiens	175-179
32673751-10	2020	Previous studies have shown that the presentation of BMP2 via extracellular matrix molecules, such as heparan sulfate (HS), can upregulate BMP2 signaling.	Heparitin Sulfate	102-117	bone morphogenetic protein 2	Homo sapiens	53-57
32992731-2	2020	Proposed mechanisms involve host cell membrane-bound angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine proteases (TTSPs), such as transmembrane serine protease isoform 2 (TMPRSS2), lysosomal endopeptidase Cathepsin L (CTSL), subtilisin-like proprotein peptidase furin (FURIN), and even potentially membrane bound heparan sulfate proteoglycans.	Heparitin Sulfate	332-347	angiotensin converting enzyme 2	Homo sapiens	53-84
32992731-2	2020	Proposed mechanisms involve host cell membrane-bound angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine proteases (TTSPs), such as transmembrane serine protease isoform 2 (TMPRSS2), lysosomal endopeptidase Cathepsin L (CTSL), subtilisin-like proprotein peptidase furin (FURIN), and even potentially membrane bound heparan sulfate proteoglycans.	Heparitin Sulfate	332-347	angiotensin converting enzyme 2	Homo sapiens	86-90
32992731-2	2020	Proposed mechanisms involve host cell membrane-bound angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine proteases (TTSPs), such as transmembrane serine protease isoform 2 (TMPRSS2), lysosomal endopeptidase Cathepsin L (CTSL), subtilisin-like proprotein peptidase furin (FURIN), and even potentially membrane bound heparan sulfate proteoglycans.	Heparitin Sulfate	332-347	transmembrane serine protease 2	Homo sapiens	190-197
32856704-4	2020	Recently, we identified and characterized the lysosomal enzyme arylsulfatase K (Arsk) exhibiting glucuronate-2-sulfatase activity as needed for the degradation of heparan sulfate (HS), chondroitin sulfate (CS) and dermatan sulfate (DS).	Heparitin Sulfate	163-178	arylsulfatase K	Mus musculus	63-78
32856704-4	2020	Recently, we identified and characterized the lysosomal enzyme arylsulfatase K (Arsk) exhibiting glucuronate-2-sulfatase activity as needed for the degradation of heparan sulfate (HS), chondroitin sulfate (CS) and dermatan sulfate (DS).	Heparitin Sulfate	163-178	arylsulfatase K	Mus musculus	80-84
32673751-10	2020	Previous studies have shown that the presentation of BMP2 via extracellular matrix molecules, such as heparan sulfate (HS), can upregulate BMP2 signaling.	Heparitin Sulfate	102-117	bone morphogenetic protein 2	Homo sapiens	139-143
32673751-10	2020	Previous studies have shown that the presentation of BMP2 via extracellular matrix molecules, such as heparan sulfate (HS), can upregulate BMP2 signaling.	Heparitin Sulfate	119-121	bone morphogenetic protein 2	Homo sapiens	53-57
32673751-10	2020	Previous studies have shown that the presentation of BMP2 via extracellular matrix molecules, such as heparan sulfate (HS), can upregulate BMP2 signaling.	Heparitin Sulfate	119-121	bone morphogenetic protein 2	Homo sapiens	139-143
32673751-7	2020	Finally, we proved that HS co-immobilized with cRGD both sustained BMP2 signaling and enhanced osteogenic differentiation compared to BMP2 directly immobilized on streptavidin, even with a low cRGD surface concentration.	Heparitin Sulfate	24-26	bone morphogenetic protein 2	Homo sapiens	67-71
32673751-8	2020	Altogether, our results show that HS facilitated and sustained the synergy between BMP2 and integrin pathways and that the co-immobilization of HS and cRGD peptides optimised BMP2-mediated osteogenic differentiation.	Heparitin Sulfate	34-36	bone morphogenetic protein 2	Homo sapiens	83-87
32915137-4	2020	We discovered that inclusion of the positively charged A1 insert in mouse neuroligin-1 increases its binding to heparan sulphate, a modification on neurexin.	Heparitin Sulfate	112-128	neuroligin 1	Mus musculus	74-86
32785987-1	2020	BACKGROUND: Mucopolysaccharidosis type I (MPS-I) is a lysosomal storage disorder caused by a deficiency of the enzyme alpha-l-iduronidase, leading to accumulation of undegraded dermatan and heparan sulfates in the cells and secondary multiorgan dysfunction.	Heparitin Sulfate	190-206	alpha-L-iduronidase	Canis lupus familiaris	118-137
32697099-4	2020	Reduced hydrophobic and electrostatic interactions of MSN@PLA-PEG-CPP with mucus decreased mucus trapping by 36.0%, increased cellular uptake of MSN@PLA-PEG-CPP 2.3-fold in mucous conditions via active, heparan sulfate proteoglycan receptor-mediated and caveolae-mediated endocytosis and electrostatic interactions.	Heparitin Sulfate	203-218	moesin	Homo sapiens	54-57
32697099-4	2020	Reduced hydrophobic and electrostatic interactions of MSN@PLA-PEG-CPP with mucus decreased mucus trapping by 36.0%, increased cellular uptake of MSN@PLA-PEG-CPP 2.3-fold in mucous conditions via active, heparan sulfate proteoglycan receptor-mediated and caveolae-mediated endocytosis and electrostatic interactions.	Heparitin Sulfate	203-218	moesin	Homo sapiens	145-148
32706374-6	2020	In hippocampal cultures, expression of exogenous FAM19A1 decreased neurexin O-glycosylation and suppressed its heparan sulfate modification, suggesting that FAM19As regulate the post-translational modification of neurexins.	Heparitin Sulfate	111-126	TAFA chemokine like family member 1	Homo sapiens	49-56
32543879-8	2020	CXCL4 blocked viral attachment through binding to the RSV main receptor heparan sulfate, instead of interacting with RSV surface proteins.	Heparitin Sulfate	72-87	platelet factor 4	Homo sapiens	0-5
31965290-1	2020	INTRODUCTION: Mucopolysaccharidosis (MPS) IIIB is a lysosomal disorder in which a deficiency in alpha-N-acetylglucosaminidase impairs the degradation of heparan sulphate, which accumulates in tissues causing multiple organs dysfunction.	Heparitin Sulfate	153-169	N-acetyl-alpha-glucosaminidase	Homo sapiens	96-125
32899927-1	2020	Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate and has been shown in various cancers to promote metastasis, angiogenesis, osteolysis, and chemoresistance.	Heparitin Sulfate	53-68	heparanase	Homo sapiens	0-10
32899927-1	2020	Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate and has been shown in various cancers to promote metastasis, angiogenesis, osteolysis, and chemoresistance.	Heparitin Sulfate	53-68	heparanase	Homo sapiens	12-16
32683952-1	2020	Sulfatase 2 (SULF2) is a heparan sulfate editing enzyme that regulates the milieu of growth factors and cytokines involved in a variety of cellular processes.	Heparitin Sulfate	25-40	sulfatase 2	Mus musculus	0-11
32683952-1	2020	Sulfatase 2 (SULF2) is a heparan sulfate editing enzyme that regulates the milieu of growth factors and cytokines involved in a variety of cellular processes.	Heparitin Sulfate	25-40	sulfatase 2	Mus musculus	13-18
32698687-8	2020	Overexpressing Kir2.1 in endothelium of arteries from obese mice restored flow- and heparanase-sensitivity, indicating an important role for heparan sulfates in the flow-activation of Kir.	Heparitin Sulfate	141-157	potassium inwardly-rectifying channel, subfamily J, member 2	Mus musculus	15-21
32698687-8	2020	Overexpressing Kir2.1 in endothelium of arteries from obese mice restored flow- and heparanase-sensitivity, indicating an important role for heparan sulfates in the flow-activation of Kir.	Heparitin Sulfate	141-157	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	15-18
32772683-2	2020	Heparan sulfate (HS) sugars play important roles in regulating VEGF bioactivity in the pericellular compartment.	Heparitin Sulfate	0-15	vascular endothelial growth factor A	Rattus norvegicus	63-67
32460635-5	2020	In this AuNP-PMS/FGF2 composite, PMS, playing as the high-active mimic of heparin/heparan sulfate (HS), is covalently anchored to AuNPs and bound with FGF2 on the surface of nanoparticles, forming a HS/FGF2 complex nanomimics to facilitate its binding to FGF receptor (FGFR) and promote high neural-inductive activity of mESCs.	Heparitin Sulfate	82-97	fibroblast growth factor 2	Mus musculus	17-21
32460635-5	2020	In this AuNP-PMS/FGF2 composite, PMS, playing as the high-active mimic of heparin/heparan sulfate (HS), is covalently anchored to AuNPs and bound with FGF2 on the surface of nanoparticles, forming a HS/FGF2 complex nanomimics to facilitate its binding to FGF receptor (FGFR) and promote high neural-inductive activity of mESCs.	Heparitin Sulfate	82-97	fibroblast growth factor 2	Mus musculus	151-155
32460635-5	2020	In this AuNP-PMS/FGF2 composite, PMS, playing as the high-active mimic of heparin/heparan sulfate (HS), is covalently anchored to AuNPs and bound with FGF2 on the surface of nanoparticles, forming a HS/FGF2 complex nanomimics to facilitate its binding to FGF receptor (FGFR) and promote high neural-inductive activity of mESCs.	Heparitin Sulfate	82-97	fibroblast growth factor 2	Mus musculus	151-155
32772683-2	2020	Heparan sulfate (HS) sugars play important roles in regulating VEGF bioactivity in the pericellular compartment.	Heparitin Sulfate	17-19	vascular endothelial growth factor A	Rattus norvegicus	63-67
32843889-1	2020	Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the animal cell surface and in the extracellular matrix.	Heparitin Sulfate	120-135	exostosin like glycosyltransferase 3	Homo sapiens	0-16
32848136-4	2020	The functional requirement for ITGB3 derives from its interactions with heparan sulfate proteoglycans (HSPGs) and the process of integrin endocytosis, allowing the capture of extracellular vesicles and their endocytosis-mediated internalization.	Heparitin Sulfate	72-87	integrin subunit beta 3	Homo sapiens	31-36
32859014-2	2020	Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan sulfates (HS) that are attached at the extracellular domain of syndecan-1.	Heparitin Sulfate	79-95	syndecan 1	Homo sapiens	150-160
32859014-2	2020	Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan sulfates (HS) that are attached at the extracellular domain of syndecan-1.	Heparitin Sulfate	97-99	syndecan 1	Homo sapiens	150-160
32843889-1	2020	Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the animal cell surface and in the extracellular matrix.	Heparitin Sulfate	120-135	exostosin like glycosyltransferase 3	Homo sapiens	18-23
32843889-1	2020	Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the animal cell surface and in the extracellular matrix.	Heparitin Sulfate	137-139	exostosin like glycosyltransferase 3	Homo sapiens	0-16
32843889-1	2020	Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the animal cell surface and in the extracellular matrix.	Heparitin Sulfate	137-139	exostosin like glycosyltransferase 3	Homo sapiens	18-23
32843889-5	2020	Compared with the established function of EXTL3 as a glycosyltransferase in HS biosynthesis, the REG-receptor function of EXTL3 is not conclusive.	Heparitin Sulfate	76-78	exostosin like glycosyltransferase 3	Homo sapiens	42-47
32522852-4	2020	PAPST1 is a sulfotransferase involved in heparan sulfate proteoglycan synthesis encoded by the solute carrier family 35 member B2 gene (SLC35B2).	Heparitin Sulfate	41-56	solute carrier family 35 member B2	Homo sapiens	0-6
32074489-2	2020	TG2 is unconventionally secreted through extracellular vesicles in a way that depends on heparan sulphate (HS) proteoglycan syndecan-4 (Sdc4), the deletion of which reduces experimental kidney fibrosis as a result of lower extracellular TG2 in the tubule-interstitium.	Heparitin Sulfate	89-105	transglutaminase 2	Rattus norvegicus	0-3
32074489-2	2020	TG2 is unconventionally secreted through extracellular vesicles in a way that depends on heparan sulphate (HS) proteoglycan syndecan-4 (Sdc4), the deletion of which reduces experimental kidney fibrosis as a result of lower extracellular TG2 in the tubule-interstitium.	Heparitin Sulfate	89-105	syndecan 4	Rattus norvegicus	136-140
32074489-2	2020	TG2 is unconventionally secreted through extracellular vesicles in a way that depends on heparan sulphate (HS) proteoglycan syndecan-4 (Sdc4), the deletion of which reduces experimental kidney fibrosis as a result of lower extracellular TG2 in the tubule-interstitium.	Heparitin Sulfate	107-109	transglutaminase 2	Rattus norvegicus	0-3
32074489-2	2020	TG2 is unconventionally secreted through extracellular vesicles in a way that depends on heparan sulphate (HS) proteoglycan syndecan-4 (Sdc4), the deletion of which reduces experimental kidney fibrosis as a result of lower extracellular TG2 in the tubule-interstitium.	Heparitin Sulfate	107-109	syndecan 4	Rattus norvegicus	136-140
32074489-4	2020	HS-binding TG2 mutants had reduced extracellular TG2 in transfected NRK-52E, suggesting that TG2-externalisation depends on an intact TG2 heparin binding site.	Heparitin Sulfate	0-2	transglutaminase 2	Rattus norvegicus	11-14
32074489-4	2020	HS-binding TG2 mutants had reduced extracellular TG2 in transfected NRK-52E, suggesting that TG2-externalisation depends on an intact TG2 heparin binding site.	Heparitin Sulfate	0-2	transglutaminase 2	Rattus norvegicus	49-52
32074489-4	2020	HS-binding TG2 mutants had reduced extracellular TG2 in transfected NRK-52E, suggesting that TG2-externalisation depends on an intact TG2 heparin binding site.	Heparitin Sulfate	0-2	transglutaminase 2	Rattus norvegicus	49-52
32074489-4	2020	HS-binding TG2 mutants had reduced extracellular TG2 in transfected NRK-52E, suggesting that TG2-externalisation depends on an intact TG2 heparin binding site.	Heparitin Sulfate	0-2	transglutaminase 2	Rattus norvegicus	49-52
32522852-4	2020	PAPST1 is a sulfotransferase involved in heparan sulfate proteoglycan synthesis encoded by the solute carrier family 35 member B2 gene (SLC35B2).	Heparitin Sulfate	41-56	solute carrier family 35 member B2	Homo sapiens	95-129
32522852-4	2020	PAPST1 is a sulfotransferase involved in heparan sulfate proteoglycan synthesis encoded by the solute carrier family 35 member B2 gene (SLC35B2).	Heparitin Sulfate	41-56	solute carrier family 35 member B2	Homo sapiens	136-143
32522852-7	2020	Thus, PAPST1-triggered synthesis of cell surface heparan sulfate is required for the efficient replication of SBV and other bunyaviruses.IMPORTANCE SBV is a newly emerging orthobunyavirus (family Peribunyaviridae) that has spread rapidly across Europe since 2011, resulting in substantial economic losses in livestock farming.	Heparitin Sulfate	49-64	solute carrier family 35 member B2	Homo sapiens	6-12
32849563-6	2020	Heparan sulfate proteoglycan dependency of the pattern recognition of properdin was evaluated on PTEC knocked down for syndecan-1 by shRNA technology.	Heparitin Sulfate	0-15	syndecan 1	Homo sapiens	119-129
32849532-1	2020	CD138 (syndecan 1), a member of the heparan-sulfate proteoglycan family, regulates diverse biological responses by interacting with chemokines, cytokines, growth factors, and adhesion molecules.	Heparitin Sulfate	36-51	syndecan 1	Mus musculus	0-5
32530114-4	2020	Here, we investigated the potential involvement of heparan sulfate proteoglycans (HSPGs) in augmented FGFR1 signaling and cellular senescence.	Heparitin Sulfate	51-66	fibroblast growth factor receptor 1	Mus musculus	102-107
32494847-3	2020	This was associated with the surge in the levels of one of key scaffolding heparan sulfate proteoglycans of endothelial glycocalyx, syndecan-4, and specifically, its extracellular domain (ectodomain).	Heparitin Sulfate	75-90	syndecan 4	Mus musculus	132-142
32767333-5	2020	Syndecan-1 (CD138) is a transmembrane heparan sulfate proteoglycan expressed and actively shed by most myeloma cells.	Heparitin Sulfate	38-53	syndecan 1	Homo sapiens	0-10
32767333-5	2020	Syndecan-1 (CD138) is a transmembrane heparan sulfate proteoglycan expressed and actively shed by most myeloma cells.	Heparitin Sulfate	38-53	syndecan 1	Homo sapiens	12-17
32562306-2	2020	We have previously reported the heparan sulfate proteoglycans (HSPGs) glypican-1 (GPC1) and -4 (GPC4) as the markers of lineage-specific human neural stem cells (hNSCs) and mediators of hNSC lineage potential.	Heparitin Sulfate	32-47	glypican 1	Homo sapiens	70-80
32562306-2	2020	We have previously reported the heparan sulfate proteoglycans (HSPGs) glypican-1 (GPC1) and -4 (GPC4) as the markers of lineage-specific human neural stem cells (hNSCs) and mediators of hNSC lineage potential.	Heparitin Sulfate	32-47	glypican 1	Homo sapiens	82-86
32562306-2	2020	We have previously reported the heparan sulfate proteoglycans (HSPGs) glypican-1 (GPC1) and -4 (GPC4) as the markers of lineage-specific human neural stem cells (hNSCs) and mediators of hNSC lineage potential.	Heparitin Sulfate	32-47	glypican 4	Homo sapiens	96-100
32562306-3	2020	Here, we further examined phenotypical characteristics and GPC1 and GPC4 during neural differentiation of hNSCs in the presence of two neurogenic growth factors reported to bind to heparan sulfate: brain-derived neurotrophic factor (BDNF) and platelet-derived growth factor-B (PDGF-B).	Heparitin Sulfate	181-196	brain derived neurotrophic factor	Homo sapiens	233-237
32849532-1	2020	CD138 (syndecan 1), a member of the heparan-sulfate proteoglycan family, regulates diverse biological responses by interacting with chemokines, cytokines, growth factors, and adhesion molecules.	Heparitin Sulfate	36-51	syndecan 1	Mus musculus	7-17
32709762-0	2020	Correction: Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.	Heparitin Sulfate	20-35	hepcidin antimicrobial peptide	Homo sapiens	61-69
32701966-1	2020	Syndecan-1 (Sdc-1) is a heparan sulfate proteoglycan that can bind cytokines and chemokines via its heparan sulfate side chains, and has immunomodulatory properties in experimental models.	Heparitin Sulfate	24-39	syndecan 1	Homo sapiens	0-10
32701966-1	2020	Syndecan-1 (Sdc-1) is a heparan sulfate proteoglycan that can bind cytokines and chemokines via its heparan sulfate side chains, and has immunomodulatory properties in experimental models.	Heparitin Sulfate	24-39	syndecan 1	Homo sapiens	12-17
32701966-1	2020	Syndecan-1 (Sdc-1) is a heparan sulfate proteoglycan that can bind cytokines and chemokines via its heparan sulfate side chains, and has immunomodulatory properties in experimental models.	Heparitin Sulfate	100-115	syndecan 1	Homo sapiens	0-10
32701966-1	2020	Syndecan-1 (Sdc-1) is a heparan sulfate proteoglycan that can bind cytokines and chemokines via its heparan sulfate side chains, and has immunomodulatory properties in experimental models.	Heparitin Sulfate	100-115	syndecan 1	Homo sapiens	12-17
32636266-0	2020	Antiresorptive activity of osteoprotegerin requires an intact heparan sulfate-binding site.	Heparitin Sulfate	62-77	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	27-42
32636266-3	2020	We have previously shown that one likely function of the C-terminal domains of OPG is to bind cell surface heparan sulfate (HS), but the in vivo evidence was lacking.	Heparitin Sulfate	107-122	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	79-82
32636266-3	2020	We have previously shown that one likely function of the C-terminal domains of OPG is to bind cell surface heparan sulfate (HS), but the in vivo evidence was lacking.	Heparitin Sulfate	124-126	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	79-82
32636266-7	2020	Mechanistically, we propose that the HS immobilizes secreted OPG at the surface of osteoblasts lineage cells, which facilitates binding of OPG to membrane-anchored RANKL.	Heparitin Sulfate	37-39	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	61-64
32636266-7	2020	Mechanistically, we propose that the HS immobilizes secreted OPG at the surface of osteoblasts lineage cells, which facilitates binding of OPG to membrane-anchored RANKL.	Heparitin Sulfate	37-39	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	139-142
32636266-7	2020	Mechanistically, we propose that the HS immobilizes secreted OPG at the surface of osteoblasts lineage cells, which facilitates binding of OPG to membrane-anchored RANKL.	Heparitin Sulfate	37-39	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	164-169
32699847-3	2020	Here we use murine leukemia viruses pseudotyped with Spike from SARS-CoV or SARS-CoV-2 to demonstrate that ACE2-mediated coronavirus entry can be mitigated by heparin, a heparan sulfate-related glycan, or by genetic ablation of biosynthetic enzymes for the cell surface heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	170-185	angiotensin converting enzyme 2	Homo sapiens	107-111
32760722-3	2020	This stroma is rich in extracellular matrix (ECM) factors, including heparan sulfate proteoglycans (HSPGs), such as the BC-associated syndecan-1 (SDC1).	Heparitin Sulfate	69-84	syndecan 1	Homo sapiens	134-144
32699847-3	2020	Here we use murine leukemia viruses pseudotyped with Spike from SARS-CoV or SARS-CoV-2 to demonstrate that ACE2-mediated coronavirus entry can be mitigated by heparin, a heparan sulfate-related glycan, or by genetic ablation of biosynthetic enzymes for the cell surface heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	270-285	angiotensin converting enzyme 2	Homo sapiens	107-111
32760722-3	2020	This stroma is rich in extracellular matrix (ECM) factors, including heparan sulfate proteoglycans (HSPGs), such as the BC-associated syndecan-1 (SDC1).	Heparitin Sulfate	69-84	syndecan 1	Mus musculus	146-150
32699853-5	2020	Unfractionated heparin, non-anticoagulant heparin, treatment with heparin lyases, and purified lung heparan sulfate potently block spike protein binding and infection by spike protein-pseudotyped virus and SARS-CoV-2 virus.	Heparitin Sulfate	100-115	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	170-175
32699853-1	2020	We show that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain.	Heparitin Sulfate	66-81	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	24-29
32699853-2	2020	Docking studies suggest a putative heparin/heparan sulfate-binding site adjacent to the domain that binds to ACE2.	Heparitin Sulfate	43-58	angiotensin converting enzyme 2	Homo sapiens	109-113
32760727-0	2020	Heparan Sulfate Proteoglycan Clustering in Wnt Signaling and Dispersal.	Heparitin Sulfate	0-15	Wnt oncogene analog 2	Drosophila melanogaster	43-46
32760727-3	2020	Heparan sulfate proteoglycans (HSPGs) are extracellular regulators involved in Wnt ligand dispersal.	Heparitin Sulfate	0-15	Wnt oncogene analog 2	Drosophila melanogaster	79-82
32699853-4	2020	Contrary to studies with purified components, spike protein binding to heparan sulfate and ACE2 on cells occurs codependently.	Heparitin Sulfate	71-86	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	46-51
32699853-5	2020	Unfractionated heparin, non-anticoagulant heparin, treatment with heparin lyases, and purified lung heparan sulfate potently block spike protein binding and infection by spike protein-pseudotyped virus and SARS-CoV-2 virus.	Heparitin Sulfate	100-115	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	131-136
32765462-7	2020	Finally the results of binding blocking assay and infection inhibition assay showed that recombinant HSPA8 protein and antibody to HSPA8 could inhibit IBV Beaudette strain infection of Vero cells that were treated with heparanase to remove heparan sulfate from the cell surface.	Heparitin Sulfate	240-255	heat shock protein family A (Hsp70) member 8	Homo sapiens	101-106
32664575-1	2020	Disruption of the Heparan sulfate (HS)-biosynthetic gene N-acetylglucosamine N-Deacetylase/N-sulfotransferase 1 (Ndst1) during nervous system development causes malformations that are composites of those caused by mutations of multiple HS binding growth factors and morphogens.	Heparitin Sulfate	18-33	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	113-118
32664575-1	2020	Disruption of the Heparan sulfate (HS)-biosynthetic gene N-acetylglucosamine N-Deacetylase/N-sulfotransferase 1 (Ndst1) during nervous system development causes malformations that are composites of those caused by mutations of multiple HS binding growth factors and morphogens.	Heparitin Sulfate	35-37	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	113-118
32664575-3	2020	Therefore, we generated mice bearing a Purkinje-cell-specific deletion in Ndst1 gene function by using Cre/loxP technology under the control of the Purkinje cell protein 2 (Pcp2/L7) promotor, which results in HS undersulfation.	Heparitin Sulfate	209-211	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	74-79
32664575-3	2020	Therefore, we generated mice bearing a Purkinje-cell-specific deletion in Ndst1 gene function by using Cre/loxP technology under the control of the Purkinje cell protein 2 (Pcp2/L7) promotor, which results in HS undersulfation.	Heparitin Sulfate	209-211	Purkinje cell protein 2 (L7)	Mus musculus	148-171
32765462-7	2020	Finally the results of binding blocking assay and infection inhibition assay showed that recombinant HSPA8 protein and antibody to HSPA8 could inhibit IBV Beaudette strain infection of Vero cells that were treated with heparanase to remove heparan sulfate from the cell surface.	Heparitin Sulfate	240-255	heat shock protein family A (Hsp70) member 8	Homo sapiens	131-136
32159248-0	2020	Distribution of heparan sulfate correlated with the expression of heparanase-1 and matrix metalloproteinase-9 in an ovariectomized rats skin.	Heparitin Sulfate	16-31	matrix metallopeptidase 9	Rattus norvegicus	83-109
32636307-6	2020	This cleavage induced the release of TSP-1 C-terminal domains from the extracellular matrix and abolished its previously described multisite cooperative interactions with heparan sulfate proteoglycans and CD36 on HT1080 cells.	Heparitin Sulfate	171-186	thrombospondin 1	Homo sapiens	37-42
32371389-11	2020	Wnt3a co-localised with heparan sulfate proteoglycans in the pericellular matrix of chondrocytes in OA cartilage, in which canonical Wnt signalling was activated.	Heparitin Sulfate	24-39	wingless-type MMTV integration site family, member 3A	Mus musculus	0-5
32371389-11	2020	Wnt3a co-localised with heparan sulfate proteoglycans in the pericellular matrix of chondrocytes in OA cartilage, in which canonical Wnt signalling was activated.	Heparitin Sulfate	24-39	Wnt family member 3A	Homo sapiens	0-3
32515730-2	2020	Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis.	Heparitin Sulfate	131-147	N-deacetylase and N-sulfotransferase 1	Homo sapiens	107-112
32573073-7	2020	Further, ARTN also interacts with heparan sulphate proteoglycan syndecan-3 and mediates non-RET signalling via activation of Src kinases.	Heparitin Sulfate	34-50	artemin	Homo sapiens	9-13
32573073-7	2020	Further, ARTN also interacts with heparan sulphate proteoglycan syndecan-3 and mediates non-RET signalling via activation of Src kinases.	Heparitin Sulfate	34-50	syndecan 3	Homo sapiens	64-74
32276212-4	2020	Conjugation with MES is used to edge a negative charge that can mimic CCR5 and Heparan sulfate (initial point of contact of HIV-1 env to host cell surface) electrostatic charge (Sulfate group).	Heparitin Sulfate	79-94	endogenous retrovirus group K member 20	Homo sapiens	130-133
32377957-2	2020	Heparanase is a protein capable of degrading heparan sulfate (HS) chains.	Heparitin Sulfate	45-60	heparanase	Homo sapiens	0-10
32377957-2	2020	Heparanase is a protein capable of degrading heparan sulfate (HS) chains.	Heparitin Sulfate	62-64	heparanase	Homo sapiens	0-10
32699853-6	2020	These findings support a model for SARS-CoV-2 infection in which viral attachment and infection involves formation of a complex between heparan sulfate and ACE2.	Heparitin Sulfate	136-151	angiotensin converting enzyme 2	Homo sapiens	156-160
32515730-2	2020	Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis.	Heparitin Sulfate	149-151	N-deacetylase and N-sulfotransferase 1	Homo sapiens	107-112
32656005-9	2020	Heparan sulfate (HS) normally acts as a storage site for basic fibroblast growth factor (bFGF), a paracrine stimulator of aldosterone, but accumulates in MPS-IIIA due to deficiency of heparan sulfatase.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	57-87
32577638-4	2020	In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells.	Heparitin Sulfate	167-182	angiotensin converting enzyme 2	Homo sapiens	72-103
32577638-4	2020	In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells.	Heparitin Sulfate	167-182	angiotensin converting enzyme 2	Homo sapiens	105-110
32656005-9	2020	Heparan sulfate (HS) normally acts as a storage site for basic fibroblast growth factor (bFGF), a paracrine stimulator of aldosterone, but accumulates in MPS-IIIA due to deficiency of heparan sulfatase.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	89-93
32656005-9	2020	Heparan sulfate (HS) normally acts as a storage site for basic fibroblast growth factor (bFGF), a paracrine stimulator of aldosterone, but accumulates in MPS-IIIA due to deficiency of heparan sulfatase.	Heparitin Sulfate	17-19	fibroblast growth factor 2	Homo sapiens	57-87
32656005-9	2020	Heparan sulfate (HS) normally acts as a storage site for basic fibroblast growth factor (bFGF), a paracrine stimulator of aldosterone, but accumulates in MPS-IIIA due to deficiency of heparan sulfatase.	Heparitin Sulfate	17-19	fibroblast growth factor 2	Homo sapiens	89-93
32503118-2	2020	Earlier, we demonstrated that plasma membrane-associated heparan sulfate proteoglycans (HSPGs) bind the extracellular Hsp90 and thereby promote the Hsp90-mediated motility of tumor cells.	Heparitin Sulfate	57-72	heat shock protein 90 alpha family class A member 1	Homo sapiens	148-153
32485953-3	2020	Heparan sulfate proteoglycans (HSPGs) such as cell membrane-bound syndecans (SDCs) and glypicans (GPCs) mediate hMSC lineage differentiation and with syndecan-1 (SDC-1) reported in both adipogenesis and osteogenesis, these macromolecules are potential regulators of the osteo-adipogenic balance.	Heparitin Sulfate	0-15	syndecan 1	Homo sapiens	150-160
32503118-2	2020	Earlier, we demonstrated that plasma membrane-associated heparan sulfate proteoglycans (HSPGs) bind the extracellular Hsp90 and thereby promote the Hsp90-mediated motility of tumor cells.	Heparitin Sulfate	57-72	heat shock protein 90 alpha family class A member 1	Homo sapiens	118-123
32320623-3	2020	Using mass spectrometry, we found that heparan sulfate was shed into the airspace for up to three weeks after intratracheal bleomycin-induced lung injury and coincided with induction of matrix metalloproteinases (including matrix metalloproteinase 2).	Heparitin Sulfate	39-54	matrix metallopeptidase 2	Mus musculus	223-249
32320623-4	2020	Delayed inhibition of metalloproteinases, beginning seven days after bleomycin using the nonspecific MMP inhibitor doxycycline, attenuated heparan sulfate shedding and improved lung function, suggesting that heparan sulfate shedding may impair lung recovery.	Heparitin Sulfate	139-154	matrix metallopeptidase 2	Mus musculus	101-104
32320623-7	2020	We hypothesized that matrix metalloproteinase-associated heparan sulfate shedding contributed to delayed lung recovery in part by the release of large, highly sulfated fragments that sequestered lung-reparative growth factors such as hepatocyte growth factor.	Heparitin Sulfate	57-72	hepatocyte growth factor	Mus musculus	234-258
32320623-8	2020	In vitro, heparan sulfate bound hepatocyte growth factor and attenuated growth factor signaling, suggesting that heparan sulfate shed into the airspace after injury may directly impair lung repair.	Heparitin Sulfate	10-25	hepatocyte growth factor	Mus musculus	32-56
32320623-8	2020	In vitro, heparan sulfate bound hepatocyte growth factor and attenuated growth factor signaling, suggesting that heparan sulfate shed into the airspace after injury may directly impair lung repair.	Heparitin Sulfate	113-128	hepatocyte growth factor	Mus musculus	32-56
32485953-3	2020	Heparan sulfate proteoglycans (HSPGs) such as cell membrane-bound syndecans (SDCs) and glypicans (GPCs) mediate hMSC lineage differentiation and with syndecan-1 (SDC-1) reported in both adipogenesis and osteogenesis, these macromolecules are potential regulators of the osteo-adipogenic balance.	Heparitin Sulfate	0-15	syndecan 1	Homo sapiens	162-167
32471161-1	2020	Heparan sulfate proteoglycan syndecan-1, CD138, is known to be associated with cell proliferation, adhesion, and migration in malignancies.	Heparitin Sulfate	0-15	syndecan 1	Homo sapiens	29-39
32471161-1	2020	Heparan sulfate proteoglycan syndecan-1, CD138, is known to be associated with cell proliferation, adhesion, and migration in malignancies.	Heparitin Sulfate	0-15	syndecan 1	Homo sapiens	41-46
32456321-1	2020	Syndecan-4 is a member of the syndecan family of transmembrane heparan sulfate proteoglycans, and is involved in cell protection, proliferation, and the blood coagulation-fibrinolytic system in vascular endothelial cells.	Heparitin Sulfate	63-78	syndecan 4	Bos taurus	0-10
32456321-2	2020	Heparan sulfate chains enable fibroblast growth factor-2 (FGF-2) to form a complex with its receptor and to transduce the cell growth signal.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Bos taurus	30-56
32456321-2	2020	Heparan sulfate chains enable fibroblast growth factor-2 (FGF-2) to form a complex with its receptor and to transduce the cell growth signal.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Bos taurus	58-63
32205445-1	2020	Endorepellin, the C-terminal fragment of the heparan sulfate proteoglycan perlecan, influences various signaling pathways in endothelial cells by binding to VEGFR2.	Heparitin Sulfate	45-60	kinase insert domain receptor	Homo sapiens	157-163
32398079-3	2020	HSPG biosynthesis is a complex process involving enzymatic attachment of heparan sulfate (HS) chains to a core protein.	Heparitin Sulfate	73-88	syndecan 2	Homo sapiens	0-4
32432544-3	2020	We now show that heparan sulfate proteoglycans (HSPGs) act as alternative co-receptors for RSPO3 using a combination of ligand mutagenesis and ligand engineering.	Heparitin Sulfate	17-32	R-spondin 3	Homo sapiens	91-96
32432544-5	2020	Conversely, the HSPG-binding domains of RSPO3 can be entirely replaced with an antibody that recognizes heparan sulfate (HS) chains attached to multiple HSPGs without diminishing WNT-potentiating activity in cultured cells and intestinal organoids.	Heparitin Sulfate	104-119	R-spondin 3	Homo sapiens	40-45
32432544-5	2020	Conversely, the HSPG-binding domains of RSPO3 can be entirely replaced with an antibody that recognizes heparan sulfate (HS) chains attached to multiple HSPGs without diminishing WNT-potentiating activity in cultured cells and intestinal organoids.	Heparitin Sulfate	16-18	R-spondin 3	Homo sapiens	40-45
32413029-3	2020	As a heparan sulfate proteoglycan, perlecan (HSPG2) stores and stabilizes growth factors, including heparin-binding Wnt3A, a positive regulator of PCa cell growth.	Heparitin Sulfate	5-20	heparan sulfate proteoglycan 2	Homo sapiens	45-50
32366836-7	2020	Furthermore, siRNA-mediated silencing of heparan sulfate (HS)-synthesizing enzyme, exostosin-2, leads to decreased internalization of BDTOs, prevented tau-induced autophagy-lysosomal pathway impairment, and decreased hyperphosphorylated tau levels.	Heparitin Sulfate	41-56	exostosin glycosyltransferase 2	Homo sapiens	83-94
32187531-5	2020	Our binding analyses further revealed that glycosaminoglycans, heparin and heparan sulfate, are ligands for OTK and thus may play a role in the Sema1a-PlexA axon guidance system.	Heparitin Sulfate	75-90	off-track	Drosophila melanogaster	108-111
32187531-5	2020	Our binding analyses further revealed that glycosaminoglycans, heparin and heparan sulfate, are ligands for OTK and thus may play a role in the Sema1a-PlexA axon guidance system.	Heparitin Sulfate	75-90	Semaphorin 1a	Drosophila melanogaster	144-150
32187531-5	2020	Our binding analyses further revealed that glycosaminoglycans, heparin and heparan sulfate, are ligands for OTK and thus may play a role in the Sema1a-PlexA axon guidance system.	Heparitin Sulfate	75-90	Plexin A	Drosophila melanogaster	151-156
32366836-7	2020	Furthermore, siRNA-mediated silencing of heparan sulfate (HS)-synthesizing enzyme, exostosin-2, leads to decreased internalization of BDTOs, prevented tau-induced autophagy-lysosomal pathway impairment, and decreased hyperphosphorylated tau levels.	Heparitin Sulfate	58-60	exostosin glycosyltransferase 2	Homo sapiens	83-94
32222663-2	2020	HPSE-mediated breakdown of structural heparan sulfate (HS) networks in the extracellular matrix (ECM) and basement membranes (BM) directly facilitates tumor growth and metastasis.	Heparitin Sulfate	38-53	heparanase	Homo sapiens	0-4
32222663-2	2020	HPSE-mediated breakdown of structural heparan sulfate (HS) networks in the extracellular matrix (ECM) and basement membranes (BM) directly facilitates tumor growth and metastasis.	Heparitin Sulfate	55-57	heparanase	Homo sapiens	0-4
32477959-1	2020	The heparan sulfate proteoglycan Syndecan-1 binds cytokines, morphogens and extracellular matrix components, regulating cancer stem cell properties and invasiveness.	Heparitin Sulfate	4-19	syndecan 1	Homo sapiens	33-43
32477959-2	2020	Syndecan-1 is modulated by the heparan sulfate-degrading enzyme heparanase, but the underlying regulatory mechanisms are only poorly understood.	Heparitin Sulfate	31-46	syndecan 1	Homo sapiens	0-10
32477959-2	2020	Syndecan-1 is modulated by the heparan sulfate-degrading enzyme heparanase, but the underlying regulatory mechanisms are only poorly understood.	Heparitin Sulfate	31-46	heparanase	Homo sapiens	64-74
32425936-4	2020	Interaction of human MASP-2 with heparan sulfate/heparin was evaluated by surface plasmon resonance, ELISA and in renal tissue.	Heparitin Sulfate	33-48	MBL associated serine protease 2	Homo sapiens	21-27
32425936-9	2020	Surface plasmon resonance showed MASP-2 binding with heparin and heparan sulfate, revealing high Kon and Koff rates resulted in a Kd of ~2 muM and confirmed inhibition by heparin-derived tetrasaccharide.	Heparitin Sulfate	65-80	MBL associated serine protease 2	Homo sapiens	33-39
32425936-10	2020	In renal tissue, MASP-2 partially colocalized with agrin and heparan sulfate, but not with activated C3, suggesting docking, storage, and potential inactivation of MASP-2 by heparan sulfate in basement membranes.	Heparitin Sulfate	61-76	MBL associated serine protease 2	Homo sapiens	17-23
32425936-10	2020	In renal tissue, MASP-2 partially colocalized with agrin and heparan sulfate, but not with activated C3, suggesting docking, storage, and potential inactivation of MASP-2 by heparan sulfate in basement membranes.	Heparitin Sulfate	174-189	MBL associated serine protease 2	Homo sapiens	17-23
32277030-0	2020	ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis.	Heparitin Sulfate	53-68	zinc finger protein 263	Homo sapiens	0-6
32425936-10	2020	In renal tissue, MASP-2 partially colocalized with agrin and heparan sulfate, but not with activated C3, suggesting docking, storage, and potential inactivation of MASP-2 by heparan sulfate in basement membranes.	Heparitin Sulfate	174-189	MBL associated serine protease 2	Homo sapiens	164-170
32277030-6	2020	Examination of the promoter regions of all genes involved in heparin/heparan sulfate assembly uncovered a transcription factor-binding motif for ZNF263, a C2H2 zinc finger protein.	Heparitin Sulfate	69-84	zinc finger protein 263	Sus scrofa	145-151
32425936-11	2020	Our data show that highly sulfated GAGs mediated inhibition of all three complement pathways, whereas short heparin- and heparan sulfate-derived oligosaccharides selectively blocked the lectin pathway via MASP-2 inhibition.	Heparitin Sulfate	121-136	MBL associated serine protease 2	Homo sapiens	205-211
32425936-12	2020	Binding of MASP-2 to immobilized heparan sulfate/heparin and partial co-localization of agrin/heparan sulfate with MASP, but not C3b, might suggest that in vivo heparan sulfate proteoglycans act as a docking platform for MASP-2 and possibly prevent the lectin pathway from activation.	Heparitin Sulfate	33-48	MBL associated serine protease 2	Homo sapiens	11-17
32169857-0	2020	Correction: Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.	Heparitin Sulfate	20-35	hepcidin antimicrobial peptide	Homo sapiens	61-69
32313611-3	2020	Syndecan-1 (Sdc1) is a member of the heparan sulfate proteoglycan family that has mainly been investigated for its role in regulating proliferation and survival of epithelia and tumor cells, but little is known about its roles in regulating obesity and glucose homeostasis.	Heparitin Sulfate	37-52	syndecan 1	Mus musculus	0-10
32313611-3	2020	Syndecan-1 (Sdc1) is a member of the heparan sulfate proteoglycan family that has mainly been investigated for its role in regulating proliferation and survival of epithelia and tumor cells, but little is known about its roles in regulating obesity and glucose homeostasis.	Heparitin Sulfate	37-52	syndecan 1	Mus musculus	12-16
32289862-1	2020	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulfate and hence participates in remodeling of the extracellular matrix, leading to release of cytokines that are immobilized by binding to heparan sulfate proteoglycans (HSPGs), and consequently activating signaling pathways.	Heparitin Sulfate	63-78	heparanase	Homo sapiens	0-10
32289862-1	2020	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulfate and hence participates in remodeling of the extracellular matrix, leading to release of cytokines that are immobilized by binding to heparan sulfate proteoglycans (HSPGs), and consequently activating signaling pathways.	Heparitin Sulfate	63-78	heparanase	Homo sapiens	12-16
32289862-1	2020	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulfate and hence participates in remodeling of the extracellular matrix, leading to release of cytokines that are immobilized by binding to heparan sulfate proteoglycans (HSPGs), and consequently activating signaling pathways.	Heparitin Sulfate	212-227	heparanase	Homo sapiens	0-10
32289862-1	2020	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulfate and hence participates in remodeling of the extracellular matrix, leading to release of cytokines that are immobilized by binding to heparan sulfate proteoglycans (HSPGs), and consequently activating signaling pathways.	Heparitin Sulfate	212-227	heparanase	Homo sapiens	12-16
32292405-5	2020	Here we identified the Heparan Sulfate Proteoglycan Syndecan 4 as the molecular switch, controlling HCV transmission by LCs.	Heparitin Sulfate	23-38	syndecan 4	Homo sapiens	52-62
32292405-6	2020	Syndecan 4 was highly upregulated upon activation of LCs and interference with Heparan Sulfate Proteoglycans or silencing of Syndecan 4 abrogated HCV transmission.	Heparitin Sulfate	79-94	syndecan 4	Homo sapiens	0-10
32292405-12	2020	Blocking Heparan Sulfate Proteoglycans abrogated HCV transmission by LCs ex vivo identifying Heparan Sulfate Proteoglycans and Syndecan 4 as potential targets to prevent sexual transmission of HCV.	Heparitin Sulfate	9-24	syndecan 4	Homo sapiens	127-137
32083852-1	2020	Human endo-O-sulfatases (Sulf-1 and Sulf-2) are extracellular heparan sulfate proteoglycan (HSPG)-specific 6-O-endosulfatases, which regulate a multitude of cell-signaling events through heparan sulfate (HS)-protein interactions and are associated with the onset of osteoarthritis.	Heparitin Sulfate	62-77	sulfatase 1	Homo sapiens	25-31
32083852-1	2020	Human endo-O-sulfatases (Sulf-1 and Sulf-2) are extracellular heparan sulfate proteoglycan (HSPG)-specific 6-O-endosulfatases, which regulate a multitude of cell-signaling events through heparan sulfate (HS)-protein interactions and are associated with the onset of osteoarthritis.	Heparitin Sulfate	62-77	sulfatase 2	Homo sapiens	36-42
32083852-1	2020	Human endo-O-sulfatases (Sulf-1 and Sulf-2) are extracellular heparan sulfate proteoglycan (HSPG)-specific 6-O-endosulfatases, which regulate a multitude of cell-signaling events through heparan sulfate (HS)-protein interactions and are associated with the onset of osteoarthritis.	Heparitin Sulfate	92-94	sulfatase 1	Homo sapiens	25-31
32083852-1	2020	Human endo-O-sulfatases (Sulf-1 and Sulf-2) are extracellular heparan sulfate proteoglycan (HSPG)-specific 6-O-endosulfatases, which regulate a multitude of cell-signaling events through heparan sulfate (HS)-protein interactions and are associated with the onset of osteoarthritis.	Heparitin Sulfate	92-94	sulfatase 2	Homo sapiens	36-42
32269093-2	2020	Here we demonstrate a functional convergence of ADAMTS-1 and the transmembrane heparan sulfate proteoglycan syndecan-4 in influencing adhesion, migration and angiogenesis.	Heparitin Sulfate	79-94	syndecan 4	Homo sapiens	108-118
32188725-4	2020	Here, we found that a heparan sulfate (HS) octadecasaccharide (18-mer-HP or hepatoprotective 18-mer) displays potent hepatoprotection by targeting the HMGB1/RAGE axis.	Heparitin Sulfate	22-37	high mobility group box 1	Homo sapiens	151-156
32188725-4	2020	Here, we found that a heparan sulfate (HS) octadecasaccharide (18-mer-HP or hepatoprotective 18-mer) displays potent hepatoprotection by targeting the HMGB1/RAGE axis.	Heparitin Sulfate	22-37	advanced glycosylation end-product specific receptor	Homo sapiens	157-161
32188725-4	2020	Here, we found that a heparan sulfate (HS) octadecasaccharide (18-mer-HP or hepatoprotective 18-mer) displays potent hepatoprotection by targeting the HMGB1/RAGE axis.	Heparitin Sulfate	39-41	high mobility group box 1	Homo sapiens	151-156
32188725-4	2020	Here, we found that a heparan sulfate (HS) octadecasaccharide (18-mer-HP or hepatoprotective 18-mer) displays potent hepatoprotection by targeting the HMGB1/RAGE axis.	Heparitin Sulfate	39-41	advanced glycosylation end-product specific receptor	Homo sapiens	157-161
32188725-6	2020	Furthermore, purified syndecan-1, but not syndecan-1 core protein, binds to HMGB1, suggesting that HMGB1 binds to HS polysaccharide side chains of syndecan-1.	Heparitin Sulfate	114-116	syndecan 1	Homo sapiens	22-32
32188725-6	2020	Furthermore, purified syndecan-1, but not syndecan-1 core protein, binds to HMGB1, suggesting that HMGB1 binds to HS polysaccharide side chains of syndecan-1.	Heparitin Sulfate	114-116	high mobility group box 1	Homo sapiens	99-104
32057196-4	2020	We identified pathogenic mechanisms of inflammasome activation, including that disease-specific 2-O-sulphated heparan sulphate was essential for priming an IL-1beta response via the Toll-like receptor 4 complex.	Heparitin Sulfate	96-126	interleukin 1 alpha	Homo sapiens	156-164
32188113-0	2020	Mucopolysaccharidosis Type I. Mucopolysaccharidosis type I (MPS I) is caused by the deficiency of alpha-l-iduronidase, leading to the storage of dermatan and heparan sulfate.	Heparitin Sulfate	158-173	alpha-L-iduronidase	Homo sapiens	98-117
32111039-1	2020	Mucopolysaccharidosis IIIB (MPS IIIB) is an inherited metabolic disease due to deficiency of alpha-N-Acetylglucosaminidase (NAGLU) enzyme with subsequent storage of undegraded heparan sulfate (HS).	Heparitin Sulfate	176-191	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	124-129
31794784-0	2020	The role of heparin/heparan sulphate in the IFN-gamma-led Arena.	Heparitin Sulfate	20-36	interferon gamma	Homo sapiens	44-53
31868274-7	2020	Interestingly, HS depletion in ECs results in the inactivation of decapentaplegic (Dpp) signaling.	Heparitin Sulfate	15-17	decapentaplegic	Drosophila melanogaster	83-86
31868274-8	2020	Moreover, ectopic Dpp signaling completely rescued the defects caused by HS depletion.	Heparitin Sulfate	73-75	decapentaplegic	Drosophila melanogaster	18-21
32111039-1	2020	Mucopolysaccharidosis IIIB (MPS IIIB) is an inherited metabolic disease due to deficiency of alpha-N-Acetylglucosaminidase (NAGLU) enzyme with subsequent storage of undegraded heparan sulfate (HS).	Heparitin Sulfate	193-195	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	124-129
32098168-6	2020	Endothelial cells exposed to laminar flow secrete SEMA3F, which subsequently binds to heparan sulfates on the surface of ECs.	Heparitin Sulfate	86-102	semaphorin 3F	Homo sapiens	50-56
31811897-3	2020	MuSK activation requires a complex interplay between its co-receptor Lrp4 (low-density lipoprotein receptor-related protein-4), the motor neuron-derived heparan-sulfate proteoglycan Agrin and the intracellular adaptor protein Dok-7.	Heparitin Sulfate	153-168	muscle associated receptor tyrosine kinase	Homo sapiens	0-4
32074129-0	2020	Human and mouse activin genes: Divergent expression of activin A protein variants and identification of a novel heparan sulfate-binding domain in activin B. Activins are members of the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins and were originally identified as components of follicular fluid.	Heparitin Sulfate	112-127	tumor necrosis factor	Homo sapiens	185-216
32074129-0	2020	Human and mouse activin genes: Divergent expression of activin A protein variants and identification of a novel heparan sulfate-binding domain in activin B. Activins are members of the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins and were originally identified as components of follicular fluid.	Heparitin Sulfate	112-127	transforming growth factor alpha	Homo sapiens	218-226
33073008-1	2020	The glycosaminoglycans (GAGs), dermatan sulfate (DS) and heparan sulfate (HS) are both substrates for alpha-l-iduronidase (IDUA).	Heparitin Sulfate	57-72	alpha-L-iduronidase	Homo sapiens	123-127
33073008-1	2020	The glycosaminoglycans (GAGs), dermatan sulfate (DS) and heparan sulfate (HS) are both substrates for alpha-l-iduronidase (IDUA).	Heparitin Sulfate	74-76	alpha-L-iduronidase	Homo sapiens	123-127
32154058-9	2020	Conclusions: Bivariate analysis of IDUA with HS in newborn DBS can accurately predict early MPSI symptoms, control false positive rates, and enhance presymptomatic treatment.	Heparitin Sulfate	45-47	alpha-L-iduronidase	Homo sapiens	35-39
31250000-4	2020	METHODS: We examined the effect of ZIKV NS1 on expression and release of heparan sulfate (HS), hyaluronic acid (HA), and sialic acid on human trophoblast cell lines and anchoring villous explants from first-trimester placentas infected with ZIKV ex vivo.	Heparitin Sulfate	73-88	influenza virus NS1A binding protein	Homo sapiens	40-43
31935212-0	2020	Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice.	Heparitin Sulfate	62-77	vascular endothelial growth factor A	Mus musculus	27-31
31935212-4	2020	Heparan sulfate (HS) act as a co-receptor for VEGF.	Heparitin Sulfate	0-15	vascular endothelial growth factor A	Mus musculus	46-50
31935212-4	2020	Heparan sulfate (HS) act as a co-receptor for VEGF.	Heparitin Sulfate	17-19	vascular endothelial growth factor A	Mus musculus	46-50
32274719-10	2020	The chapter also describes the cooperation between exostin loss-of-function and heparanase upregulation in hereditary Multiple Osteochondroma syndrome as a paradigmatic example of constitutive alteration of the heparanase/heparan sulfate proteoglycan system which may contribute to progression to malignant secondary chondrosarcoma.	Heparitin Sulfate	222-237	heparanase	Homo sapiens	80-90
32274730-5	2020	The endoglycosidase heparanase degrades heparan sulfate, thereby affecting glomerular barrier function, immune reactivity and inflammation.	Heparitin Sulfate	40-55	heparanase	Mus musculus	4-30
32266656-2	2020	Perlecan/HSPG2, a large, multi-domain heparan sulfate proteoglycan, is concentrated in the reactive stroma that surrounds tumors.	Heparitin Sulfate	38-53	heparan sulfate proteoglycan 2	Homo sapiens	9-14
32266658-1	2020	Glypican-1 (GPC-1) is a cell surface heparan sulphate proteoglycan that is critical during normal development, but which is not required for normal homoeostasis in the adult.	Heparitin Sulfate	37-53	glypican 1	Homo sapiens	0-10
32266658-1	2020	Glypican-1 (GPC-1) is a cell surface heparan sulphate proteoglycan that is critical during normal development, but which is not required for normal homoeostasis in the adult.	Heparitin Sulfate	37-53	glypican 1	Homo sapiens	12-17
32274706-7	2020	More unexpectedly, heparanase also influences heparan sulfate biosynthesis, such that overexpression of the enzyme results in generation of highly sulfated, heparin-like oligosaccharides.	Heparitin Sulfate	46-61	heparanase	Homo sapiens	19-29
32274707-1	2020	Heparanase is an endo-beta-glucuronidase that cleaves at a limited number of internal sites the glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	114-129	heparanase	Homo sapiens	0-10
32274707-1	2020	Heparanase is an endo-beta-glucuronidase that cleaves at a limited number of internal sites the glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	131-133	heparanase	Homo sapiens	0-10
32274707-2	2020	Heparanase enzymatic activity was first reported in 1975 and by 1983 evidence was beginning to emerge that the enzyme was a facilitator of tumor metastasis by cleaving HS chains present in blood vessel basement membranes and, thereby, aiding the passage of tumor cells through blood vessel walls.	Heparitin Sulfate	168-170	heparanase	Homo sapiens	0-10
32274730-6	2020	Increased expression of glomerular heparanase correlates with loss of glomerular heparan sulfate in many glomerular diseases.	Heparitin Sulfate	81-96	heparanase	Mus musculus	35-45
32274731-3	2020	Heparanase (HPSE), which is the enzyme that cuts off the side chains of heparan sulfate (HS) proteoglycan, appears to be involved in the aetiopathogenesis of fibrosis in all these organs, even if with different mechanisms.	Heparitin Sulfate	72-87	heparanase	Homo sapiens	0-10
32274731-3	2020	Heparanase (HPSE), which is the enzyme that cuts off the side chains of heparan sulfate (HS) proteoglycan, appears to be involved in the aetiopathogenesis of fibrosis in all these organs, even if with different mechanisms.	Heparitin Sulfate	72-87	heparanase	Homo sapiens	12-16
32274731-3	2020	Heparanase (HPSE), which is the enzyme that cuts off the side chains of heparan sulfate (HS) proteoglycan, appears to be involved in the aetiopathogenesis of fibrosis in all these organs, even if with different mechanisms.	Heparitin Sulfate	89-91	heparanase	Homo sapiens	0-10
32274707-15	2020	The enzymatic activity of heparanase has also emerged in unexpected situations, such as in the spread of HS-binding viruses and in Type-1 diabetes where the destruction of intracellular HS in pancreatic insulin-producing beta cells precipitates diabetes.	Heparitin Sulfate	105-107	heparanase	Homo sapiens	26-36
32274707-15	2020	The enzymatic activity of heparanase has also emerged in unexpected situations, such as in the spread of HS-binding viruses and in Type-1 diabetes where the destruction of intracellular HS in pancreatic insulin-producing beta cells precipitates diabetes.	Heparitin Sulfate	186-188	heparanase	Homo sapiens	26-36
32274731-3	2020	Heparanase (HPSE), which is the enzyme that cuts off the side chains of heparan sulfate (HS) proteoglycan, appears to be involved in the aetiopathogenesis of fibrosis in all these organs, even if with different mechanisms.	Heparitin Sulfate	89-91	heparanase	Homo sapiens	12-16
32274708-1	2020	The cell surface heparan sulfate proteoglycan Syndecan-1 acts as an important co-receptor for receptor tyrosine kinases and chemokine receptors, and as an adhesion receptor for structural glycoproteins of the extracellular matrix.	Heparitin Sulfate	17-32	syndecan 1	Homo sapiens	46-56
32274709-1	2020	The retaining endo-beta-D-glucuronidase Heparanase (HPSE) is the primary mammalian enzyme responsible for breakdown of the glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	141-156	heparanase	Homo sapiens	52-56
32274709-1	2020	The retaining endo-beta-D-glucuronidase Heparanase (HPSE) is the primary mammalian enzyme responsible for breakdown of the glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	158-160	heparanase	Homo sapiens	52-56
32274732-2	2020	Human heparanase-1 is critically and uniquely engaged in cleavage of heparan sulfate, an integral part of glycocalyx and extracellular matrix where it harbors distinct growth factors, cytokines, and other biologically active molecules.	Heparitin Sulfate	69-84	heparanase	Homo sapiens	6-18
32274711-2	2020	Heparanase remains the only known enzyme to cleave heparan sulfate, which is an abundant component of the extracellular matrix.	Heparitin Sulfate	51-66	heparanase	Homo sapiens	0-10
32274733-3	2020	Heparanase (Hpa) is an endoglycosidase that cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HSPGs) into shorter oligosaccharides, activity that is highly implicated in cell invasion associated with cancer metastasis and inflammation.	Heparitin Sulfate	52-67	heparanase	Homo sapiens	0-10
32274717-1	2020	Heparanase is upregulated in various tumors, and its expression is closely associated with tumor growth, angiogenesis and metastasis, which accomplishes this mainly through degrading heparan sulfate and releasing heparin-binding growth factors thereby influencing multiple signaling pathways.	Heparitin Sulfate	183-198	heparanase	Homo sapiens	0-10
32274733-3	2020	Heparanase (Hpa) is an endoglycosidase that cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HSPGs) into shorter oligosaccharides, activity that is highly implicated in cell invasion associated with cancer metastasis and inflammation.	Heparitin Sulfate	52-67	heparanase	Homo sapiens	12-15
32274733-3	2020	Heparanase (Hpa) is an endoglycosidase that cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HSPGs) into shorter oligosaccharides, activity that is highly implicated in cell invasion associated with cancer metastasis and inflammation.	Heparitin Sulfate	88-103	heparanase	Homo sapiens	0-10
32274733-3	2020	Heparanase (Hpa) is an endoglycosidase that cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HSPGs) into shorter oligosaccharides, activity that is highly implicated in cell invasion associated with cancer metastasis and inflammation.	Heparitin Sulfate	88-103	heparanase	Homo sapiens	12-15
32274736-1	2020	The story of heparanase (HPSE) in viral infection has roots in the longstanding connection between heparan sulfate (HS) and a large number of viruses.	Heparitin Sulfate	99-114	heparanase	Homo sapiens	13-23
32274736-1	2020	The story of heparanase (HPSE) in viral infection has roots in the longstanding connection between heparan sulfate (HS) and a large number of viruses.	Heparitin Sulfate	99-114	heparanase	Homo sapiens	25-29
32274736-1	2020	The story of heparanase (HPSE) in viral infection has roots in the longstanding connection between heparan sulfate (HS) and a large number of viruses.	Heparitin Sulfate	116-118	heparanase	Homo sapiens	13-23
32274736-1	2020	The story of heparanase (HPSE) in viral infection has roots in the longstanding connection between heparan sulfate (HS) and a large number of viruses.	Heparitin Sulfate	116-118	heparanase	Homo sapiens	25-29
32274738-2	2020	HPSE1 at the time was widely regarded as being the sole mammalian enzyme capable of cleaving Heparan Sulfate (HS).	Heparitin Sulfate	93-108	heparanase	Homo sapiens	0-5
32274738-2	2020	HPSE1 at the time was widely regarded as being the sole mammalian enzyme capable of cleaving Heparan Sulfate (HS).	Heparitin Sulfate	110-112	heparanase	Homo sapiens	0-5
32274740-1	2020	In this chapter, we will emphasize the importance of heparan sulfate proteoglycans (HSPG) in controlling various physiological and pathological molecular mechanisms and discuss how the heparanase enzyme can modulate the effects triggered by HSPG.	Heparitin Sulfate	53-68	syndecan 2	Homo sapiens	84-88
32306341-2	2020	ZG16p binds to mannose via the well-conserved GXXXD loop among mJRLs and sulfated glycosaminoglycans (e.g., heparin and heparan sulfate) via the basic patch of molecular surface.	Heparitin Sulfate	120-135	zymogen granule protein 16	Rattus norvegicus	0-5
32175019-3	2020	Loading of Anti-miR-21 at various N/P ratios was investigated by gel retardation, ethidium bromide dye exclusion, heparin sulfate competition and DNase I digestion experiments.	Heparitin Sulfate	114-129	microRNA 21	Homo sapiens	16-22
32002903-5	2020	In addition, many plasma proteins such as antithrombin III, superoxide dismutase, C1 inhibitor, and growth factors and cytokines bind to heparan sulfate and by this scenario contribute to the establishment of an anticoagulant and anti-inflammatory endothelial surface.	Heparitin Sulfate	137-152	serpin family C member 1	Homo sapiens	42-58
31385193-4	2019	In MPS IIIA patients, the excess of lysosomal storage of heparan sulfate often leads to mental retardation, hyperactive behavior, and connective tissue impairments, which occur due to various known missense mutations in the SGSH, leading to protein dysfunction.	Heparitin Sulfate	57-72	N-sulfoglucosamine sulfohydrolase	Homo sapiens	224-228
31518222-2	2020	As a kind of endo-beta-dglucuronidase, heparanase is the known only enzyme in mammals which could degrade heparan sulfate(HS) specifically.	Heparitin Sulfate	106-121	heparanase	Homo sapiens	39-49
32186269-4	2020	OBJECTIVE: The effect of Ca2+ and Zn2+ on the amyloid fibril formation by beta-casein was investigated in the absence and presence of HS, which was significantly to explore the relationship between the concentration changes of Ca2+ and Zn2+ and amyloid fibril formation.	Heparitin Sulfate	134-136	casein beta	Homo sapiens	74-85
32186269-5	2020	METHOD: In this work, the influence of Ca2+ and Zn2+ on the beta-casein fibril formation in the absence and presence of HS was investigated by various methods of Thioflavin T fluorescence assay, transmission electron microscopy and intrinsic fluorescence measure.	Heparitin Sulfate	120-122	casein beta	Homo sapiens	60-71
32186269-10	2020	CONCLUSION: Ca2+ and Zn2+ were capable of promoting the beta-casein fibril formation in the both absence and presence of HS.	Heparitin Sulfate	121-123	casein beta	Homo sapiens	56-67
31834878-8	2019	Among the validated genes we focused on, one of the most consistent genetic modifier genes protecting against pTDP accumulation and motor deficits was the heparan sulfate-modifying enzyme hse-5, the C. elegans homolog of glucuronic acid epimerase (GLCE).	Heparitin Sulfate	155-170	D-glucuronyl C5-epimerase	Caenorhabditis elegans	188-193
31834878-8	2019	Among the validated genes we focused on, one of the most consistent genetic modifier genes protecting against pTDP accumulation and motor deficits was the heparan sulfate-modifying enzyme hse-5, the C. elegans homolog of glucuronic acid epimerase (GLCE).	Heparitin Sulfate	155-170	glucuronic acid epimerase	Homo sapiens	221-246
31834878-8	2019	Among the validated genes we focused on, one of the most consistent genetic modifier genes protecting against pTDP accumulation and motor deficits was the heparan sulfate-modifying enzyme hse-5, the C. elegans homolog of glucuronic acid epimerase (GLCE).	Heparitin Sulfate	155-170	glucuronic acid epimerase	Homo sapiens	248-252
31834922-2	2019	IDUA codes for alpha-L-iduronidase (IDUA), a lysosomal hydrolase that degrades glycosaminoglycans (GAGs): heparan sulphate and dermatan sulphate.	Heparitin Sulfate	106-122	iduronidase, alpha-L	Mus musculus	0-4
31834922-2	2019	IDUA codes for alpha-L-iduronidase (IDUA), a lysosomal hydrolase that degrades glycosaminoglycans (GAGs): heparan sulphate and dermatan sulphate.	Heparitin Sulfate	106-122	iduronidase, alpha-L	Mus musculus	36-40
31330188-1	2019	OBJECTIVE: Exostosin-1 (Ext1) encodes a glycosyltransferase required for heparan sulfate (HS) chain elongation in HS-proteoglycan biosynthesis.	Heparitin Sulfate	73-88	exostosin glycosyltransferase 1	Mus musculus	11-22
30907009-1	2019	BACKGROUND: Sanfilippo syndrome (mucopolysaccharidosis type IIIA; MPS IIIA) is an inherited paediatric-onset neurodegenerative disorder caused by the lysosomal deficiency of sulphamidase with subsequent accumulation of heparan sulphate.	Heparitin Sulfate	219-235	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	174-186
31744142-2	2019	Over the last several decades, a neuron-specific isoform of agrin, a heparan sulfate proteoglycan, has been identified as playing a central role in synapse formation at all vertebrate skeletal neuromuscular synapses.	Heparitin Sulfate	69-84	agrin	Mus musculus	60-65
31543446-3	2019	Sorting of LPL requires bivalent interactions between LPL and SDC1-linked heparan sulfate chains and between LPL and the Golgi membrane.	Heparitin Sulfate	74-89	lipoprotein lipase	Homo sapiens	11-14
31543446-3	2019	Sorting of LPL requires bivalent interactions between LPL and SDC1-linked heparan sulfate chains and between LPL and the Golgi membrane.	Heparitin Sulfate	74-89	syndecan 1	Homo sapiens	62-66
31526452-2	2019	Previously, we determined that DENV nonstructural protein 1 (NS1) induces endothelial hyperpermeability, disrupts the endothelial glycocalyx layer (EGL) in vitro and triggers shedding of structural components, including sialic acid (Sia) and heparan sulfate.	Heparitin Sulfate	242-257	influenza virus NS1A binding protein	Homo sapiens	61-64
31777174-3	2019	Temporally controlled GF perturbations of MAPK signaling dynamics applied using microfluidics reveal that this wider mix of ERK states emerges through the combination of an intracellular feedback, and competition of FGF2 binding to FGF receptors (FGFRs) and heparan sulfate proteoglycan (HSPG) co-receptors.	Heparitin Sulfate	258-273	Eph receptor B1	Rattus norvegicus	124-127
31493777-8	2019	Mechanistically, sepsis-induced eGC breakdown required the loss of its main constituent heparan sulfate; a result of heparan sulfate-specific enzyme heparanase, which was suppressed by Tie2 activation.	Heparitin Sulfate	88-103	TEK receptor tyrosine kinase	Homo sapiens	185-189
31493777-8	2019	Mechanistically, sepsis-induced eGC breakdown required the loss of its main constituent heparan sulfate; a result of heparan sulfate-specific enzyme heparanase, which was suppressed by Tie2 activation.	Heparitin Sulfate	117-132	TEK receptor tyrosine kinase	Homo sapiens	185-189
31461325-9	2019	Increased 6-O-sulfation coincided with loss of endothelial sulfatase-1 (Sulf-1), an enzyme that specifically removes 6-O-sulfates from heparan sulfate.	Heparitin Sulfate	135-150	sulfatase 1	Mus musculus	59-70
31461325-9	2019	Increased 6-O-sulfation coincided with loss of endothelial sulfatase-1 (Sulf-1), an enzyme that specifically removes 6-O-sulfates from heparan sulfate.	Heparitin Sulfate	135-150	sulfatase 1	Mus musculus	72-78
31330188-12	2019	Conversely, Ext1 overexpressing cells, with higher HS content, showed decreased chondrogenic differentiation and enhanced Wnt/beta-catenin signaling.	Heparitin Sulfate	51-53	exostosin glycosyltransferase 1	Mus musculus	12-16
31330188-1	2019	OBJECTIVE: Exostosin-1 (Ext1) encodes a glycosyltransferase required for heparan sulfate (HS) chain elongation in HS-proteoglycan biosynthesis.	Heparitin Sulfate	73-88	exostosin glycosyltransferase 1	Mus musculus	24-28
31481501-4	2019	We show that heparanase, the sole mammalian endoglucuronidase that cleaves heparan sulfate in ECM, is preferentially expressed in clinical/experimental obesity-associated breast tumors.	Heparitin Sulfate	75-90	heparanase	Homo sapiens	13-23
31619273-8	2019	We show that extracellular histones bind to the heparan sulfate proteoglycan CD138 on the surface of MM cells to promote the creation of immune-tumor cell clusters bringing immune and MM cells into close proximity, and thus facilitating not only NK but also T lymphocyte anti-MM activity.	Heparitin Sulfate	48-63	syndecan 1	Homo sapiens	77-82
31434553-9	2019	Mechanistically, both Sulfs reduced HS sulfation in the infarcted myocardium, thereby diminishing Vegfa (vascular endothelial growth factor A) interaction with HS.	Heparitin Sulfate	160-162	vascular endothelial growth factor A	Mus musculus	105-141
31434553-0	2019	Heparan Sulfate-Editing Extracellular Sulfatases Enhance VEGF Bioavailability for Ischemic Heart Repair.	Heparitin Sulfate	0-15	vascular endothelial growth factor A	Mus musculus	57-61
31434553-3	2019	SULF2 (Sulf2 in mice) and its isoform SULF1 (Sulf1) act as endosulfatases removing 6-O-sulfate groups from heparan sulfate (HS) in the extracellular space, thus eliminating docking sites for HS-binding proteins.	Heparitin Sulfate	107-122	sulfatase 2	Mus musculus	0-5
31434553-3	2019	SULF2 (Sulf2 in mice) and its isoform SULF1 (Sulf1) act as endosulfatases removing 6-O-sulfate groups from heparan sulfate (HS) in the extracellular space, thus eliminating docking sites for HS-binding proteins.	Heparitin Sulfate	107-122	sulfatase 2	Mus musculus	7-12
31434553-3	2019	SULF2 (Sulf2 in mice) and its isoform SULF1 (Sulf1) act as endosulfatases removing 6-O-sulfate groups from heparan sulfate (HS) in the extracellular space, thus eliminating docking sites for HS-binding proteins.	Heparitin Sulfate	107-122	sulfatase 1	Mus musculus	38-43
31434553-3	2019	SULF2 (Sulf2 in mice) and its isoform SULF1 (Sulf1) act as endosulfatases removing 6-O-sulfate groups from heparan sulfate (HS) in the extracellular space, thus eliminating docking sites for HS-binding proteins.	Heparitin Sulfate	107-122	sulfatase 1	Mus musculus	45-50
31434553-3	2019	SULF2 (Sulf2 in mice) and its isoform SULF1 (Sulf1) act as endosulfatases removing 6-O-sulfate groups from heparan sulfate (HS) in the extracellular space, thus eliminating docking sites for HS-binding proteins.	Heparitin Sulfate	124-126	sulfatase 2	Mus musculus	0-5
31434553-3	2019	SULF2 (Sulf2 in mice) and its isoform SULF1 (Sulf1) act as endosulfatases removing 6-O-sulfate groups from heparan sulfate (HS) in the extracellular space, thus eliminating docking sites for HS-binding proteins.	Heparitin Sulfate	124-126	sulfatase 2	Mus musculus	7-12
31434553-3	2019	SULF2 (Sulf2 in mice) and its isoform SULF1 (Sulf1) act as endosulfatases removing 6-O-sulfate groups from heparan sulfate (HS) in the extracellular space, thus eliminating docking sites for HS-binding proteins.	Heparitin Sulfate	124-126	sulfatase 1	Mus musculus	38-43
31434553-3	2019	SULF2 (Sulf2 in mice) and its isoform SULF1 (Sulf1) act as endosulfatases removing 6-O-sulfate groups from heparan sulfate (HS) in the extracellular space, thus eliminating docking sites for HS-binding proteins.	Heparitin Sulfate	124-126	sulfatase 1	Mus musculus	45-50
31537875-6	2019	The microfluidic chip flow model confirmed that HPSE2 prevented heparan sulfate shedding by HPSE1.	Heparitin Sulfate	64-79	heparanase 2	Mus musculus	48-53
31434553-9	2019	Mechanistically, both Sulfs reduced HS sulfation in the infarcted myocardium, thereby diminishing Vegfa (vascular endothelial growth factor A) interaction with HS.	Heparitin Sulfate	36-38	vascular endothelial growth factor A	Mus musculus	98-103
31434553-9	2019	Mechanistically, both Sulfs reduced HS sulfation in the infarcted myocardium, thereby diminishing Vegfa (vascular endothelial growth factor A) interaction with HS.	Heparitin Sulfate	36-38	vascular endothelial growth factor A	Mus musculus	105-141
31434553-9	2019	Mechanistically, both Sulfs reduced HS sulfation in the infarcted myocardium, thereby diminishing Vegfa (vascular endothelial growth factor A) interaction with HS.	Heparitin Sulfate	160-162	vascular endothelial growth factor A	Mus musculus	98-103
31424293-1	2019	Background: Glypican 3 (GPC3), a plasma membrane heparan sulfate proteoglycan, is overexpressed on human hepatocellular carcinoma and may represent a promising biomarker.	Heparitin Sulfate	49-64	glypican 3	Homo sapiens	12-22
31424293-1	2019	Background: Glypican 3 (GPC3), a plasma membrane heparan sulfate proteoglycan, is overexpressed on human hepatocellular carcinoma and may represent a promising biomarker.	Heparitin Sulfate	49-64	glypican 3	Homo sapiens	24-28
30963603-9	2019	In contrast with the heparan sulfate chains, the Wnt-binding groove that we identified in the protein core of GPC3 seemed to promote Wnt signaling in conditions when FZD was not abundant.	Heparitin Sulfate	21-36	glypican 3	Mus musculus	110-114
31495905-4	2019	By contrast, FGF19, 21, and 23 coevolve through losing binding affinity for extracellular matrix heparan sulfate while acquiring affinity for transmembrane alpha-Klotho (KL) or beta-KL as a coreceptor, thereby adapting to an endocrine mode of action to drive interorgan crosstalk that regulates a broad spectrum of metabolic homeostasis.	Heparitin Sulfate	97-112	fibroblast growth factor 19	Homo sapiens	13-18
31211456-4	2019	EXT-1 and EXT-2 encode glycosyltransferases that are necessary for the synthesis of heparin sulfate.	Heparitin Sulfate	84-99	exostosin glycosyltransferase 1	Homo sapiens	0-5
31211456-4	2019	EXT-1 and EXT-2 encode glycosyltransferases that are necessary for the synthesis of heparin sulfate.	Heparitin Sulfate	84-99	exostosin glycosyltransferase 2	Homo sapiens	10-15
31341044-7	2019	Sialylated glycans and heparan sulfate chains covalently attached to the SPOCK2 core protein were critical for its antiviral activity.	Heparitin Sulfate	23-38	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2	Mus musculus	73-79
31341044-10	2019	Testican-2/SPOCK2 is a complex type of secreted proteoglycan with heparan sulfate GAG chains attached to the core protein.	Heparitin Sulfate	66-81	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2	Mus musculus	11-17
31341044-12	2019	Treatment with purified testican-2/SPOCK2 protein can efficiently block influenza virus infection in vitro and in vivo We also identified the heparan sulfate moiety as a key regulatory module for this inhibitory effect.	Heparitin Sulfate	142-157	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2	Mus musculus	35-41
31660087-5	2019	On the other hand, the LRK sequence exhibited a good binding affinity with the proteoglycan heparan sulfate and could act as a cofactor by sustaining the release of embedded growth factors.	Heparitin Sulfate	92-107	versican	Gallus gallus	79-91
31537875-7	2019	Furthermore, heparan sulfate did not interfere with cluster of differentiation-14 (CD14)-dependent LPS binding, but instead reduced the presentation of the LPS to TLR4.	Heparitin Sulfate	13-28	toll-like receptor 4	Mus musculus	163-167
31032901-1	2019	Heparanase is an endo-beta-d-glucuronidase that cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans.	Heparitin Sulfate	56-71	heparanase	Homo sapiens	0-10
31533830-1	2019	BACKGROUND: During muscle regeneration, the chemokine CXCL12 (SDF-1) and the synthesis of some specific heparan sulfates (HS) have been shown to be critical.	Heparitin Sulfate	104-120	chemokine (C-X-C motif) ligand 12	Mus musculus	54-60
31533830-1	2019	BACKGROUND: During muscle regeneration, the chemokine CXCL12 (SDF-1) and the synthesis of some specific heparan sulfates (HS) have been shown to be critical.	Heparitin Sulfate	104-120	chemokine (C-X-C motif) ligand 12	Mus musculus	62-67
31533830-1	2019	BACKGROUND: During muscle regeneration, the chemokine CXCL12 (SDF-1) and the synthesis of some specific heparan sulfates (HS) have been shown to be critical.	Heparitin Sulfate	122-124	chemokine (C-X-C motif) ligand 12	Mus musculus	54-60
31032901-1	2019	Heparanase is an endo-beta-d-glucuronidase that cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans.	Heparitin Sulfate	73-75	heparanase	Homo sapiens	0-10
31032901-1	2019	Heparanase is an endo-beta-d-glucuronidase that cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans.	Heparitin Sulfate	92-107	heparanase	Homo sapiens	0-10
31020862-1	2019	Patients with the lysosomal storage disease mucopolysaccharidosis IIIA (MPSIIIA) lack the lysosomal enzyme N-sulfoglucosamine sulfohydrolase (SGSH), one of the many enzymes involved in degradation of heparan sulfate.	Heparitin Sulfate	200-215	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	142-146
31315930-0	2019	Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.	Heparitin Sulfate	8-23	hepcidin antimicrobial peptide	Homo sapiens	49-57
31315930-3	2019	Proteoglycans that function as receptors of these signaling proteins in the liver are commonly decorated by heparan sulfate, but the potential role of hepatic heparan sulfate in hepcidin expression and iron homeostasis is unclear.	Heparitin Sulfate	159-174	hepcidin antimicrobial peptide	Homo sapiens	178-186
31315930-4	2019	Here, we show that modulation of hepatic heparan sulfate significantly alters hepcidin expression and iron metabolism both in vitro and in vivo Specifically, enzymatic removal of heparan sulfate from primary human hepatocytes, CRISPR/Cas9 manipulation of heparan sulfate biosynthesis in human hepatoma cells, or pharmacological manipulation of heparan sulfate-protein interactions using sodium chlorate or surfen dramatically reduced baseline and BMP6/SMAD1/5/8-dependent hepcidin expression.	Heparitin Sulfate	41-56	hepcidin antimicrobial peptide	Homo sapiens	78-86
31315930-4	2019	Here, we show that modulation of hepatic heparan sulfate significantly alters hepcidin expression and iron metabolism both in vitro and in vivo Specifically, enzymatic removal of heparan sulfate from primary human hepatocytes, CRISPR/Cas9 manipulation of heparan sulfate biosynthesis in human hepatoma cells, or pharmacological manipulation of heparan sulfate-protein interactions using sodium chlorate or surfen dramatically reduced baseline and BMP6/SMAD1/5/8-dependent hepcidin expression.	Heparitin Sulfate	41-56	bone morphogenetic protein 6	Homo sapiens	447-451
31315930-4	2019	Here, we show that modulation of hepatic heparan sulfate significantly alters hepcidin expression and iron metabolism both in vitro and in vivo Specifically, enzymatic removal of heparan sulfate from primary human hepatocytes, CRISPR/Cas9 manipulation of heparan sulfate biosynthesis in human hepatoma cells, or pharmacological manipulation of heparan sulfate-protein interactions using sodium chlorate or surfen dramatically reduced baseline and BMP6/SMAD1/5/8-dependent hepcidin expression.	Heparitin Sulfate	41-56	SMAD family member 1	Homo sapiens	452-459
31315930-4	2019	Here, we show that modulation of hepatic heparan sulfate significantly alters hepcidin expression and iron metabolism both in vitro and in vivo Specifically, enzymatic removal of heparan sulfate from primary human hepatocytes, CRISPR/Cas9 manipulation of heparan sulfate biosynthesis in human hepatoma cells, or pharmacological manipulation of heparan sulfate-protein interactions using sodium chlorate or surfen dramatically reduced baseline and BMP6/SMAD1/5/8-dependent hepcidin expression.	Heparitin Sulfate	41-56	hepcidin antimicrobial peptide	Homo sapiens	472-480
31315930-4	2019	Here, we show that modulation of hepatic heparan sulfate significantly alters hepcidin expression and iron metabolism both in vitro and in vivo Specifically, enzymatic removal of heparan sulfate from primary human hepatocytes, CRISPR/Cas9 manipulation of heparan sulfate biosynthesis in human hepatoma cells, or pharmacological manipulation of heparan sulfate-protein interactions using sodium chlorate or surfen dramatically reduced baseline and BMP6/SMAD1/5/8-dependent hepcidin expression.	Heparitin Sulfate	179-194	hepcidin antimicrobial peptide	Homo sapiens	78-86
31315930-4	2019	Here, we show that modulation of hepatic heparan sulfate significantly alters hepcidin expression and iron metabolism both in vitro and in vivo Specifically, enzymatic removal of heparan sulfate from primary human hepatocytes, CRISPR/Cas9 manipulation of heparan sulfate biosynthesis in human hepatoma cells, or pharmacological manipulation of heparan sulfate-protein interactions using sodium chlorate or surfen dramatically reduced baseline and BMP6/SMAD1/5/8-dependent hepcidin expression.	Heparitin Sulfate	179-194	hepcidin antimicrobial peptide	Homo sapiens	78-86
33654855-1	2019	Heparanase, an endo-beta-D-glucuronidase, cleaves cell surface and extracellular matrix heparan sulfate (HS) chains at distinct sites and plays important biological roles including modulation of cell growth and metastasis.	Heparitin Sulfate	88-103	heparanase	Homo sapiens	0-10
33654855-1	2019	Heparanase, an endo-beta-D-glucuronidase, cleaves cell surface and extracellular matrix heparan sulfate (HS) chains at distinct sites and plays important biological roles including modulation of cell growth and metastasis.	Heparitin Sulfate	88-103	glucuronidase beta	Homo sapiens	20-40
31544795-1	2019	IDUA contributes to the degradation of the glycosaminoglycans, including heparan sulphate and dermatan sulphate.	Heparitin Sulfate	73-89	alpha-L-iduronidase	Homo sapiens	0-4
31315930-4	2019	Here, we show that modulation of hepatic heparan sulfate significantly alters hepcidin expression and iron metabolism both in vitro and in vivo Specifically, enzymatic removal of heparan sulfate from primary human hepatocytes, CRISPR/Cas9 manipulation of heparan sulfate biosynthesis in human hepatoma cells, or pharmacological manipulation of heparan sulfate-protein interactions using sodium chlorate or surfen dramatically reduced baseline and BMP6/SMAD1/5/8-dependent hepcidin expression.	Heparitin Sulfate	179-194	hepcidin antimicrobial peptide	Homo sapiens	78-86
31315930-5	2019	Moreover inactivation of the heparan sulfate biosynthetic gene N-deacetylase and N-sulfotransferase 1 (Ndst1) in murine hepatocytes (Ndst1 f/f AlbCre +) reduced hepatic hepcidin expression and caused a redistribution of systemic iron, leading to iron accumulation in the liver and serum of mice.	Heparitin Sulfate	29-44	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	63-101
31315930-5	2019	Moreover inactivation of the heparan sulfate biosynthetic gene N-deacetylase and N-sulfotransferase 1 (Ndst1) in murine hepatocytes (Ndst1 f/f AlbCre +) reduced hepatic hepcidin expression and caused a redistribution of systemic iron, leading to iron accumulation in the liver and serum of mice.	Heparitin Sulfate	29-44	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	103-108
31315930-5	2019	Moreover inactivation of the heparan sulfate biosynthetic gene N-deacetylase and N-sulfotransferase 1 (Ndst1) in murine hepatocytes (Ndst1 f/f AlbCre +) reduced hepatic hepcidin expression and caused a redistribution of systemic iron, leading to iron accumulation in the liver and serum of mice.	Heparitin Sulfate	29-44	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	133-138
31315930-5	2019	Moreover inactivation of the heparan sulfate biosynthetic gene N-deacetylase and N-sulfotransferase 1 (Ndst1) in murine hepatocytes (Ndst1 f/f AlbCre +) reduced hepatic hepcidin expression and caused a redistribution of systemic iron, leading to iron accumulation in the liver and serum of mice.	Heparitin Sulfate	29-44	hepcidin antimicrobial peptide	Mus musculus	169-177
31315930-6	2019	Manipulation of heparan sulfate had a similar effect on IL6-dependent hepcidin expression in vitro and suppressed IL6-mediated iron redistribution induced by lipopolysaccharide in vivo These results provide compelling evidence that hepatocyte heparan sulfate plays a key role in regulating hepcidin expression and iron homeostasis in mice and in human hepatocytes.	Heparitin Sulfate	16-31	interleukin 6	Mus musculus	56-59
31315930-6	2019	Manipulation of heparan sulfate had a similar effect on IL6-dependent hepcidin expression in vitro and suppressed IL6-mediated iron redistribution induced by lipopolysaccharide in vivo These results provide compelling evidence that hepatocyte heparan sulfate plays a key role in regulating hepcidin expression and iron homeostasis in mice and in human hepatocytes.	Heparitin Sulfate	16-31	hepcidin antimicrobial peptide	Mus musculus	70-78
31315930-6	2019	Manipulation of heparan sulfate had a similar effect on IL6-dependent hepcidin expression in vitro and suppressed IL6-mediated iron redistribution induced by lipopolysaccharide in vivo These results provide compelling evidence that hepatocyte heparan sulfate plays a key role in regulating hepcidin expression and iron homeostasis in mice and in human hepatocytes.	Heparitin Sulfate	16-31	interleukin 6	Mus musculus	114-117
31315930-6	2019	Manipulation of heparan sulfate had a similar effect on IL6-dependent hepcidin expression in vitro and suppressed IL6-mediated iron redistribution induced by lipopolysaccharide in vivo These results provide compelling evidence that hepatocyte heparan sulfate plays a key role in regulating hepcidin expression and iron homeostasis in mice and in human hepatocytes.	Heparitin Sulfate	16-31	hepcidin antimicrobial peptide	Mus musculus	290-298
31315930-6	2019	Manipulation of heparan sulfate had a similar effect on IL6-dependent hepcidin expression in vitro and suppressed IL6-mediated iron redistribution induced by lipopolysaccharide in vivo These results provide compelling evidence that hepatocyte heparan sulfate plays a key role in regulating hepcidin expression and iron homeostasis in mice and in human hepatocytes.	Heparitin Sulfate	243-258	interleukin 6	Mus musculus	114-117
31467315-6	2019	EXTL3 is an N-acetyl glucosamine (GlcNAc) transferase, performing a key step in heparan sulfate (HS) glucosaminoglycan synthesis.	Heparitin Sulfate	80-95	exostosin like glycosyltransferase 3	Homo sapiens	0-5
31465316-1	2019	BACKGROUND EXT1 is an endoplasmic reticulum-resident glycosyl transferase whose intracellular expression alters the biosynthesis and distribution of heparan sulfate.	Heparitin Sulfate	149-164	exostosin glycosyltransferase 1	Homo sapiens	11-15
31308409-4	2019	Syndecan-4 (SDC4) is a transmembrane heparan sulfate proteoglycan that binds to, and modulates the activity of, many extracellular proteins implicated in placental development.	Heparitin Sulfate	37-52	syndecan 4	Homo sapiens	0-10
31391090-8	2019	We determined a novel mode of action of a therapeutic candidate antibody, which potently inhibits neuronal internalization of AD tau species by masking of epitopes present in MTBD important for interaction with neuron surface Heparan Sulfate Proteoglycans (HSPGs).	Heparitin Sulfate	226-241	microtubule associated protein tau	Homo sapiens	129-132
30980466-4	2019	Here, we addressed the role of the heparan sulfate-editing enzyme Sulf2 in the control of gliogenesis and found an unanticipated function for this enzyme.	Heparitin Sulfate	35-50	sulfatase 2	Mus musculus	66-71
31228227-1	2019	Mucopolysaccharidosis type IIIC (MPSIIIC) is a severe, rare autosomal recessive disorder caused by variants in the heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT) gene which result in lysosomal accumulation of heparan sulfate.	Heparitin Sulfate	219-234	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	164-170
31085206-0	2019	Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545.	Heparitin Sulfate	64-79	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	43-46
31085206-5	2019	Here, we investigate the potential of the heparan sulfate mimetic PG545 as a dual purpose compound to target both DENV virion infectivity and NS1 function.	Heparitin Sulfate	42-57	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	142-145
31094413-10	2019	These findings confirm that SDC1 is the dominant endocytic proteoglycan receptor for TRLs in human Hep3B cells and that binding and uptake of TRLs depend on SDC1 and N- and 2-O-sulfation as well as 6-O-sulfation of heparan sulfate chains catalyzed by HS6ST2.	Heparitin Sulfate	215-230	syndecan 1	Homo sapiens	28-32
31308409-4	2019	Syndecan-4 (SDC4) is a transmembrane heparan sulfate proteoglycan that binds to, and modulates the activity of, many extracellular proteins implicated in placental development.	Heparitin Sulfate	37-52	syndecan 4	Homo sapiens	12-16
30953622-0	2019	The cyanobacterial neurotoxin beta-N-methylamino-l-alanine prevents addition of heparan sulfate to glypican-1 and increases processing of amyloid precursor protein in dividing neuronal cells.	Heparitin Sulfate	80-95	glypican 1	Mus musculus	99-109
30806661-1	2019	Hereditary multiple osteochondromas (HMO) is a rare autosomal dominant skeletal disorder, caused by heterozygous variants in either EXT1 or EXT2, which encode proteins involved in the biogenesis of heparan sulphate.	Heparitin Sulfate	198-214	exostosin glycosyltransferase 1	Homo sapiens	132-136
30806661-1	2019	Hereditary multiple osteochondromas (HMO) is a rare autosomal dominant skeletal disorder, caused by heterozygous variants in either EXT1 or EXT2, which encode proteins involved in the biogenesis of heparan sulphate.	Heparitin Sulfate	198-214	exostosin glycosyltransferase 2	Homo sapiens	140-144
31266258-1	2019	Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular matrix proteins.	Heparitin Sulfate	0-15	syndecan 2	Homo sapiens	31-35
31266258-1	2019	Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular matrix proteins.	Heparitin Sulfate	84-101	syndecan 2	Homo sapiens	31-35
30953622-2	2019	In proteoglycans, e.g. glypican-1, this should preclude substitution with heparan sulfate chains.	Heparitin Sulfate	74-89	glypican 1	Mus musculus	23-33
30953622-6	2019	Cells expressing a recombinant, anchor-less glypican-1 secreted heparan sulfate-deficient glypican-1.	Heparitin Sulfate	64-79	glypican 1	Mus musculus	44-54
30953622-6	2019	Cells expressing a recombinant, anchor-less glypican-1 secreted heparan sulfate-deficient glypican-1.	Heparitin Sulfate	64-79	glypican 1	Mus musculus	90-100
31212795-0	2019	Tunicate Heparan Sulfate Enriched in 2-Sulfated beta-Glucuronic Acid: Structure, Anticoagulant Activity, and Inhibitory Effect on the Binding of Human Colon Adenocarcinoma Cells to Immobilized P-Selectin.	Heparitin Sulfate	9-24	selectin P	Homo sapiens	193-203
30996093-6	2019	The critical roles of EXT1 in heparan sulfate synthesis and vaccinia virus infection were confirmed.	Heparitin Sulfate	30-45	exostosin glycosyltransferase 1	Homo sapiens	22-26
30996093-7	2019	TM9SF2 was validated as a player mediating heparan sulfate expression, explaining its contribution to vaccinia virus infection.	Heparitin Sulfate	43-58	transmembrane 9 superfamily member 2	Homo sapiens	0-6
31000523-3	2019	Specifically, we showed that the TRF2 upregulation in cancer cells has extratelomeric roles in activating the expression of a network of genes involved in the biosynthesis of heparan sulfate proteoglycan, leading to profound changes in glycocalyx length and stiffness, as revealed by atomic force microscopy.	Heparitin Sulfate	175-190	telomeric repeat binding factor 2	Homo sapiens	33-37
31309128-1	2019	Deficiency in NAGLU disrupts the lysosomal turnover of heparan sulfate (HS), which results in the abnormal accumulation of partially degraded HS in cells and tissues.	Heparitin Sulfate	55-70	N-acetyl-alpha-glucosaminidase	Homo sapiens	14-19
30978702-4	2019	These BC subtypes overexpress syndecan-1 (SDC1), a transmembrane heparan sulfate proteoglycan that mediates angiogenesis as well as the proliferation and invasiveness of cancer cells.	Heparitin Sulfate	65-80	syndecan 1	Homo sapiens	30-40
30978702-4	2019	These BC subtypes overexpress syndecan-1 (SDC1), a transmembrane heparan sulfate proteoglycan that mediates angiogenesis as well as the proliferation and invasiveness of cancer cells.	Heparitin Sulfate	65-80	syndecan 1	Homo sapiens	42-46
30562054-1	2019	Altered expression of syndecan-2 (SDC2), a heparan sulfate proteoglycan, has been associated with diverse types of human cancers.	Heparitin Sulfate	43-58	syndecan 2	Homo sapiens	22-32
30562054-1	2019	Altered expression of syndecan-2 (SDC2), a heparan sulfate proteoglycan, has been associated with diverse types of human cancers.	Heparitin Sulfate	43-58	syndecan 2	Homo sapiens	34-38
30919596-5	2019	This "shedding" of syndecan-1 is inhibited by the presence of the heparan sulfate chains, which can be removed by heparanase.	Heparitin Sulfate	66-81	syndecan 1	Homo sapiens	19-29
30919596-8	2019	Inflammation associated with malaria triggers increased heparanase activity that degrades the heparan sulfate on the membrane-bound syndecan-1.	Heparitin Sulfate	94-109	syndecan 1	Homo sapiens	132-142
30919596-9	2019	Inflammation also upregulates MMP-9 and the removal of heparan sulfate gives MMP-9 access to cleave syndecan-1, thereby releasing dimeric syndecan-1 ectodomains with at least four chondroitin sulfate chains attached.	Heparitin Sulfate	55-70	matrix metallopeptidase 9	Homo sapiens	77-82
30919596-9	2019	Inflammation also upregulates MMP-9 and the removal of heparan sulfate gives MMP-9 access to cleave syndecan-1, thereby releasing dimeric syndecan-1 ectodomains with at least four chondroitin sulfate chains attached.	Heparitin Sulfate	55-70	syndecan 1	Homo sapiens	100-110
30919596-9	2019	Inflammation also upregulates MMP-9 and the removal of heparan sulfate gives MMP-9 access to cleave syndecan-1, thereby releasing dimeric syndecan-1 ectodomains with at least four chondroitin sulfate chains attached.	Heparitin Sulfate	55-70	syndecan 1	Homo sapiens	138-148
31309128-1	2019	Deficiency in NAGLU disrupts the lysosomal turnover of heparan sulfate (HS), which results in the abnormal accumulation of partially degraded HS in cells and tissues.	Heparitin Sulfate	72-74	N-acetyl-alpha-glucosaminidase	Homo sapiens	14-19
31309128-1	2019	Deficiency in NAGLU disrupts the lysosomal turnover of heparan sulfate (HS), which results in the abnormal accumulation of partially degraded HS in cells and tissues.	Heparitin Sulfate	142-144	N-acetyl-alpha-glucosaminidase	Homo sapiens	14-19
31309128-4	2019	The focus of these studies was to further characterize the ability of NAGLU-IGF2 to clear accumulated HS compared to unmodified NAGLU in primary cellular models of MPS IIIB.	Heparitin Sulfate	102-104	N-acetyl-alpha-glucosaminidase	Homo sapiens	70-80
31309128-4	2019	The focus of these studies was to further characterize the ability of NAGLU-IGF2 to clear accumulated HS compared to unmodified NAGLU in primary cellular models of MPS IIIB.	Heparitin Sulfate	102-104	N-acetyl-alpha-glucosaminidase	Homo sapiens	70-75
31309128-5	2019	Here, we establish distinct primary cell models of MPS IIIB with HS accumulation.	Heparitin Sulfate	65-67	N-acetyl-alpha-glucosaminidase	Homo sapiens	51-59
31309128-8	2019	In contrast, under conditions of limited exposure duration, NAGLU-IGF2 was taken up more rapidly than the unmodified NAGLU into MPS IIIB primary fibroblasts, astrocytes, and cortical neurons, where it efficiently degraded accumulated HS.	Heparitin Sulfate	234-236	N-acetyl-alpha-glucosaminidase	Homo sapiens	60-70
31309128-8	2019	In contrast, under conditions of limited exposure duration, NAGLU-IGF2 was taken up more rapidly than the unmodified NAGLU into MPS IIIB primary fibroblasts, astrocytes, and cortical neurons, where it efficiently degraded accumulated HS.	Heparitin Sulfate	234-236	N-acetyl-alpha-glucosaminidase	Homo sapiens	60-65
30872481-2	2019	Of these, glucuronyl C5-epimerase (Glce) catalyzes C5-epimerization of the HS component, d-glucuronic acid (GlcA), into l-iduronic acid (IdoA), which provides internal flexibility to the polymer and forges protein-binding sites to ensure polymer function.	Heparitin Sulfate	75-77	glucuronic acid epimerase	Homo sapiens	10-33
31100859-5	2019	A marine-derived, heparan sulphate-containing glycosaminoglycan extract, isolated from the crab Portunus pelagicus, was identified to inhibit human BACE1 with comparable bioactivity to that of mammalian heparin (IC50 = 1.85 mug mL-1 (R2 = 0.94) and 2.43 mug mL-1 (R2 = 0.93), respectively), while possessing highly attenuated anticoagulant activities.	Heparitin Sulfate	18-34	beta-secretase 1	Homo sapiens	148-153
31100859-5	2019	A marine-derived, heparan sulphate-containing glycosaminoglycan extract, isolated from the crab Portunus pelagicus, was identified to inhibit human BACE1 with comparable bioactivity to that of mammalian heparin (IC50 = 1.85 mug mL-1 (R2 = 0.94) and 2.43 mug mL-1 (R2 = 0.93), respectively), while possessing highly attenuated anticoagulant activities.	Heparitin Sulfate	18-34	L1 cell adhesion molecule	Mus musculus	228-232
31100859-5	2019	A marine-derived, heparan sulphate-containing glycosaminoglycan extract, isolated from the crab Portunus pelagicus, was identified to inhibit human BACE1 with comparable bioactivity to that of mammalian heparin (IC50 = 1.85 mug mL-1 (R2 = 0.94) and 2.43 mug mL-1 (R2 = 0.93), respectively), while possessing highly attenuated anticoagulant activities.	Heparitin Sulfate	18-34	L1 cell adhesion molecule	Mus musculus	258-262
30788513-0	2019	Expression and purification of recombinant extracellular sulfatase HSulf-2 allows deciphering of enzyme sub-domain coordinated role for the binding and 6-O-desulfation of heparan sulfate.	Heparitin Sulfate	171-186	sulfatase 2	Homo sapiens	67-74
31110966-1	2019	Heparanase is a beta-D-endoglucuronidase that cleaves heparan sulfate, a complex glycosaminoglycan found ubiquitously throughout mammalian cells and tissues.	Heparitin Sulfate	54-69	heparanase	Homo sapiens	0-10
30698737-4	2019	Instead, TRF2 binding to a distal regulatory element promotes the expression of SULF2, an endoglucosamine-6-sulfatase that impairs the VEGF-A association to the plasma membrane by inducing post-synthetic modification of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	220-235	telomeric repeat binding factor 2	Homo sapiens	9-13
30698737-4	2019	Instead, TRF2 binding to a distal regulatory element promotes the expression of SULF2, an endoglucosamine-6-sulfatase that impairs the VEGF-A association to the plasma membrane by inducing post-synthetic modification of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	220-235	sulfatase 2	Homo sapiens	80-85
31018591-4	2019	To interfere with reinforced Shh signaling, we examined the potential of defined heparin and heparan sulfate (HS) polysaccharides to block Shh solubilization and Ptc receptor binding.	Heparitin Sulfate	93-108	sonic hedgehog signaling molecule	Homo sapiens	139-142
31018591-6	2019	Consistent with the established binding of soluble heparin or HS to the Shh CW target motif, both polysaccharides impaired proteolytic Shh processing and release from source cells.	Heparitin Sulfate	62-64	sonic hedgehog signaling molecule	Homo sapiens	72-75
31018591-6	2019	Consistent with the established binding of soluble heparin or HS to the Shh CW target motif, both polysaccharides impaired proteolytic Shh processing and release from source cells.	Heparitin Sulfate	62-64	sonic hedgehog signaling molecule	Homo sapiens	135-138
31018591-7	2019	We also show that HS and heparin bind to, and block, another set of basic amino acids required for unimpaired Shh binding to Ptc receptors on receiving cells.	Heparitin Sulfate	18-20	sonic hedgehog signaling molecule	Homo sapiens	110-113
30952866-0	2019	N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization.	Heparitin Sulfate	54-69	syndecan 2	Mus musculus	11-21
30952866-4	2019	These differences are due to a significantly higher 6-O sulfation level in Sdc2 versus Sdc4 heparan sulfate (HS) chains, leading to an increase in VEGFA165 binding sites and formation of a ternary Sdc2-VEGFA165-VEGFR2 complex which enhances VEGFR2 activation.	Heparitin Sulfate	92-107	syndecan 4	Mus musculus	87-91
30952866-4	2019	These differences are due to a significantly higher 6-O sulfation level in Sdc2 versus Sdc4 heparan sulfate (HS) chains, leading to an increase in VEGFA165 binding sites and formation of a ternary Sdc2-VEGFA165-VEGFR2 complex which enhances VEGFR2 activation.	Heparitin Sulfate	92-107	syndecan 2	Mus musculus	197-201
30952866-4	2019	These differences are due to a significantly higher 6-O sulfation level in Sdc2 versus Sdc4 heparan sulfate (HS) chains, leading to an increase in VEGFA165 binding sites and formation of a ternary Sdc2-VEGFA165-VEGFR2 complex which enhances VEGFR2 activation.	Heparitin Sulfate	109-111	syndecan 2	Mus musculus	75-79
30952866-4	2019	These differences are due to a significantly higher 6-O sulfation level in Sdc2 versus Sdc4 heparan sulfate (HS) chains, leading to an increase in VEGFA165 binding sites and formation of a ternary Sdc2-VEGFA165-VEGFR2 complex which enhances VEGFR2 activation.	Heparitin Sulfate	109-111	syndecan 4	Mus musculus	87-91
30952866-4	2019	These differences are due to a significantly higher 6-O sulfation level in Sdc2 versus Sdc4 heparan sulfate (HS) chains, leading to an increase in VEGFA165 binding sites and formation of a ternary Sdc2-VEGFA165-VEGFR2 complex which enhances VEGFR2 activation.	Heparitin Sulfate	109-111	syndecan 2	Mus musculus	197-201
30952866-4	2019	These differences are due to a significantly higher 6-O sulfation level in Sdc2 versus Sdc4 heparan sulfate (HS) chains, leading to an increase in VEGFA165 binding sites and formation of a ternary Sdc2-VEGFA165-VEGFR2 complex which enhances VEGFR2 activation.	Heparitin Sulfate	109-111	kinase insert domain protein receptor	Mus musculus	211-217
30952866-4	2019	These differences are due to a significantly higher 6-O sulfation level in Sdc2 versus Sdc4 heparan sulfate (HS) chains, leading to an increase in VEGFA165 binding sites and formation of a ternary Sdc2-VEGFA165-VEGFR2 complex which enhances VEGFR2 activation.	Heparitin Sulfate	109-111	kinase insert domain protein receptor	Mus musculus	241-247
30872481-2	2019	Of these, glucuronyl C5-epimerase (Glce) catalyzes C5-epimerization of the HS component, d-glucuronic acid (GlcA), into l-iduronic acid (IdoA), which provides internal flexibility to the polymer and forges protein-binding sites to ensure polymer function.	Heparitin Sulfate	75-77	glucuronic acid epimerase	Homo sapiens	35-39
30096360-1	2019	It is now well recognized that heparanase, an endo-beta-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, promotes tumorigenesis by diverse mechanisms.	Heparitin Sulfate	92-107	glucuronidase beta	Homo sapiens	51-71
31001480-1	2019	Heparanase (HPSE), the only known mammalian endoglycosidase responsible for heparan sulfate cleavage, is a multi-faceted protein affecting multiple malignant behaviors in cancer cells.	Heparitin Sulfate	76-91	heparanase	Homo sapiens	0-10
31001480-1	2019	Heparanase (HPSE), the only known mammalian endoglycosidase responsible for heparan sulfate cleavage, is a multi-faceted protein affecting multiple malignant behaviors in cancer cells.	Heparitin Sulfate	76-91	heparanase	Homo sapiens	12-16
30720464-5	2019	Sepsis is associated with degradation of the endothelial glycocalyx, releasing heparan sulfate fragments (of sufficient size and sulfation to bind BDNF) into the circulation.	Heparitin Sulfate	79-94	brain derived neurotrophic factor	Homo sapiens	147-151
30720464-6	2019	Heparan sulfate fragments penetrated the hippocampal blood-brain barrier during sepsis and inhibited BDNF-mediated LTP.	Heparitin Sulfate	0-15	brain derived neurotrophic factor	Homo sapiens	101-105
30720464-7	2019	Glycoarray approaches demonstrated that the avidity of heparan sulfate for BDNF increased with sulfation at the 2-O position of iduronic acid and the N position of glucosamine.	Heparitin Sulfate	55-70	brain derived neurotrophic factor	Homo sapiens	75-79
30096360-1	2019	It is now well recognized that heparanase, an endo-beta-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, promotes tumorigenesis by diverse mechanisms.	Heparitin Sulfate	109-111	glucuronidase beta	Homo sapiens	51-71
30125619-6	2019	Furthermore, full-length BMPER is targeted to the plasma membrane via binding of its C-terminal region to cell surface heparan sulphate proteoglycans but the active cleavage fragment is diffusible.	Heparitin Sulfate	119-135	BMP binding endothelial regulator	Homo sapiens	25-30
30814516-3	2019	Secreted and furin-processed ADAMTS9 bound heparan sulfate and was internalized by LRP1, LRP2 and clathrin-mediated endocytosis to be gathered in Rab11 vesicles with a unique periciliary localization defined by super-resolution microscopy.	Heparitin Sulfate	43-58	furin, paired basic amino acid cleaving enzyme	Homo sapiens	13-18
30471091-5	2019	HS6ST2 transfers sulfate from adenosine 3"-phosphate, 5"-phosphosulfate to the sixth position of the N-sulphoglucosamine residue in heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	132-147	heparan sulfate 6-O-sulfotransferase 2	Homo sapiens	0-6
30684694-3	2019	Our study generated several HS biosynthesis-deficient cell clones by disrupting SLC35B2, B3GAT3, or B4GALT7 gene using the CRISPR/Cas9 system.	Heparitin Sulfate	28-30	solute carrier family 35 member B2	Homo sapiens	80-87
30684694-3	2019	Our study generated several HS biosynthesis-deficient cell clones by disrupting SLC35B2, B3GAT3, or B4GALT7 gene using the CRISPR/Cas9 system.	Heparitin Sulfate	28-30	beta-1,3-glucuronyltransferase 3	Homo sapiens	89-95
30684694-3	2019	Our study generated several HS biosynthesis-deficient cell clones by disrupting SLC35B2, B3GAT3, or B4GALT7 gene using the CRISPR/Cas9 system.	Heparitin Sulfate	28-30	beta-1,4-galactosyltransferase 7	Homo sapiens	100-107
30922347-1	2019	BACKGROUND: Heparanase (HPSE) is an endo-beta-glucuronidase that degrades heparan sulfate (HS) chains on proteoglycans.	Heparitin Sulfate	74-89	heparanase	Homo sapiens	12-22
30922347-1	2019	BACKGROUND: Heparanase (HPSE) is an endo-beta-glucuronidase that degrades heparan sulfate (HS) chains on proteoglycans.	Heparitin Sulfate	74-89	heparanase	Homo sapiens	24-28
30922347-1	2019	BACKGROUND: Heparanase (HPSE) is an endo-beta-glucuronidase that degrades heparan sulfate (HS) chains on proteoglycans.	Heparitin Sulfate	74-89	glucuronidase beta	Homo sapiens	41-59
30922347-1	2019	BACKGROUND: Heparanase (HPSE) is an endo-beta-glucuronidase that degrades heparan sulfate (HS) chains on proteoglycans.	Heparitin Sulfate	91-93	heparanase	Homo sapiens	12-22
30922347-1	2019	BACKGROUND: Heparanase (HPSE) is an endo-beta-glucuronidase that degrades heparan sulfate (HS) chains on proteoglycans.	Heparitin Sulfate	91-93	heparanase	Homo sapiens	24-28
30922347-1	2019	BACKGROUND: Heparanase (HPSE) is an endo-beta-glucuronidase that degrades heparan sulfate (HS) chains on proteoglycans.	Heparitin Sulfate	91-93	glucuronidase beta	Homo sapiens	41-59
30842157-0	2019	ROBO1 Expression in Metastasizing Breast and Ovarian Cancer: SLIT2-induced Chemotaxis Requires Heparan Sulfates (Heparin).	Heparitin Sulfate	95-111	slit guidance ligand 2	Homo sapiens	61-66
30659446-3	2019	Here, we demonstrated that the digestion of heparan sulfate (HS) moieties of HSPGs with a heparinase I/III blend and the metabolic inhibition of the sulfation of HS chains by sodium chlorate considerably impair the migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells stimulated by extracellular native Hsp90.	Heparitin Sulfate	44-59	heat shock protein 90 alpha family class A member 1	Homo sapiens	331-336
30659446-3	2019	Here, we demonstrated that the digestion of heparan sulfate (HS) moieties of HSPGs with a heparinase I/III blend and the metabolic inhibition of the sulfation of HS chains by sodium chlorate considerably impair the migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells stimulated by extracellular native Hsp90.	Heparitin Sulfate	61-63	heat shock protein 90 alpha family class A member 1	Homo sapiens	331-336
30659446-3	2019	Here, we demonstrated that the digestion of heparan sulfate (HS) moieties of HSPGs with a heparinase I/III blend and the metabolic inhibition of the sulfation of HS chains by sodium chlorate considerably impair the migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells stimulated by extracellular native Hsp90.	Heparitin Sulfate	77-79	heat shock protein 90 alpha family class A member 1	Homo sapiens	331-336
30818840-1	2019	In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis.	Heparitin Sulfate	41-56	heparanase	Homo sapiens	65-75
30818840-1	2019	In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis.	Heparitin Sulfate	41-56	heparanase	Homo sapiens	77-81
30818840-1	2019	In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis.	Heparitin Sulfate	58-60	heparanase	Homo sapiens	65-75
30818840-1	2019	In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis.	Heparitin Sulfate	58-60	heparanase	Homo sapiens	77-81
30818840-1	2019	In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis.	Heparitin Sulfate	177-179	heparanase	Homo sapiens	65-75
30818840-1	2019	In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis.	Heparitin Sulfate	177-179	heparanase	Homo sapiens	77-81
30814516-3	2019	Secreted and furin-processed ADAMTS9 bound heparan sulfate and was internalized by LRP1, LRP2 and clathrin-mediated endocytosis to be gathered in Rab11 vesicles with a unique periciliary localization defined by super-resolution microscopy.	Heparitin Sulfate	43-58	ADAM metallopeptidase with thrombospondin type 1 motif 9	Homo sapiens	29-36
30406694-6	2019	In addition, circular dichroism analysis showed that the spectrum changes induced by OppA-heparan sulphate binding were attenuated by the variant proteins, indicating that these motifs are the OppA recognition domains for the eukaryotic cell surface.	Heparitin Sulfate	90-106	OppA	Lactococcus lactis	85-89
30873384-1	2019	Glypican 3 (GPC3) is a heparan sulfate proteoglycan and cell surface oncofetal protein which is highly expressed on a variety of pediatric solid embryonal tumors including the majority of hepatoblastomas, Wilms tumors, rhabdoid tumors, certain germ cell tumor subtypes, and a minority of rhabdomyosarcomas.	Heparitin Sulfate	23-38	glypican 3	Homo sapiens	0-10
30873384-1	2019	Glypican 3 (GPC3) is a heparan sulfate proteoglycan and cell surface oncofetal protein which is highly expressed on a variety of pediatric solid embryonal tumors including the majority of hepatoblastomas, Wilms tumors, rhabdoid tumors, certain germ cell tumor subtypes, and a minority of rhabdomyosarcomas.	Heparitin Sulfate	23-38	glypican 3	Homo sapiens	12-16
30873384-2	2019	Via both its core protein and heparan sulfate side chains, GPC3 activates the canonical Wnt/beta-catenin pathway, which is frequently overexpressed in these malignancies.	Heparitin Sulfate	30-45	glypican 3	Homo sapiens	59-63
30873384-2	2019	Via both its core protein and heparan sulfate side chains, GPC3 activates the canonical Wnt/beta-catenin pathway, which is frequently overexpressed in these malignancies.	Heparitin Sulfate	30-45	catenin beta 1	Homo sapiens	92-104
30997052-2	2019	This case report expands the EXT2 gene mutation database and the clinical spectrum of patients with deficiencies in the heparan sulfate pathway.	Heparitin Sulfate	120-135	exostosin glycosyltransferase 2	Homo sapiens	29-33
30617207-0	2019	Heparan Sulfate Sulfation by Hs2st Restricts Astroglial Precursor Somal Translocation in Developing Mouse Forebrain by a Non-Cell-Autonomous Mechanism.	Heparitin Sulfate	0-15	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	29-34
30617207-4	2019	Here, we investigated the cell and molecular function of a specific form of HS sulfation, 2-O HS sulfation catalyzed by the enzyme Hs2st, in midline astroglial development and in regulating FGF protein levels and interaction with HS.	Heparitin Sulfate	76-78	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	131-136
30617207-4	2019	Here, we investigated the cell and molecular function of a specific form of HS sulfation, 2-O HS sulfation catalyzed by the enzyme Hs2st, in midline astroglial development and in regulating FGF protein levels and interaction with HS.	Heparitin Sulfate	76-78	fibroblast growth factor 17	Mus musculus	190-193
30617207-8	2019	Using the developing mouse telencephalic midline as an exemplar, we show that the specific sulfation modification of the cell surface and extracellular carbohydrate heparan sulfate (HS) performed by Hs2st suppresses the supply of translocation signals to astroglial precursors by a non-cell-autonomous mechanism.	Heparitin Sulfate	182-184	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	199-204
30406694-6	2019	In addition, circular dichroism analysis showed that the spectrum changes induced by OppA-heparan sulphate binding were attenuated by the variant proteins, indicating that these motifs are the OppA recognition domains for the eukaryotic cell surface.	Heparitin Sulfate	90-106	OppA	Lactococcus lactis	193-197
30414409-0	2019	The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity.	Heparitin Sulfate	20-35	transthyretin	Homo sapiens	56-69
30518643-1	2019	Histidine-rich glycoprotein (HRG) is an abundant plasma protein with a multidomain structure, allowing its interaction with many ligands, including phospholipids, plasminogen, fibrinogen, IgG antibodies, and heparan sulfate.	Heparitin Sulfate	208-223	histidine rich glycoprotein	Homo sapiens	0-27
30518643-1	2019	Histidine-rich glycoprotein (HRG) is an abundant plasma protein with a multidomain structure, allowing its interaction with many ligands, including phospholipids, plasminogen, fibrinogen, IgG antibodies, and heparan sulfate.	Heparitin Sulfate	208-223	histidine rich glycoprotein	Homo sapiens	29-32
30518643-4	2019	HRG was shown to interact with the heparan sulfate expressed by target cells, inhibiting an early postbinding step associated with HIV-1 infection.	Heparitin Sulfate	35-50	histidine rich glycoprotein	Homo sapiens	0-3
30592149-2	2019	The disease is caused by a change in the nucleotide sequence of an X-linked gene encoding glypican 3, a protein belonging to the heparan-sulfate membrane proteoglycan family.	Heparitin Sulfate	129-144	glypican 3	Homo sapiens	90-100
30470711-3	2019	This process was dependent on both PI(4,5)P2-mediated recruitment of FGF2 at the inner leaflet and heparan sulfates capturing FGF2 at the outer plasma membrane leaflet.	Heparitin Sulfate	99-115	fibroblast growth factor 2	Homo sapiens	126-130
30458230-1	2019	Glucuronyl C5-epimerase (Hsepi) catalyzes the conversion of glucuronic acid to iduronic acid in the process of heparan sulfate biosynthesis.	Heparitin Sulfate	111-126	glucuronyl C5-epimerase	Mus musculus	0-23
29553138-7	2019	Interferon-beta was induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.	Heparitin Sulfate	115-130	interferon beta 1	Homo sapiens	0-15
29553138-7	2019	Interferon-beta was induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.	Heparitin Sulfate	115-130	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	31-36
30168023-11	2019	Binding of TSP-2 to FGF2 impaired the growth factor ability to interact with its cellular receptors, since TSP-2-derived fragments prevented the binding of FGF2 to both heparin (used as a structural analog of heparan sulfate proteoglycans) and FGFR-1.	Heparitin Sulfate	209-224	thrombospondin 2	Homo sapiens	11-16
30168023-11	2019	Binding of TSP-2 to FGF2 impaired the growth factor ability to interact with its cellular receptors, since TSP-2-derived fragments prevented the binding of FGF2 to both heparin (used as a structural analog of heparan sulfate proteoglycans) and FGFR-1.	Heparitin Sulfate	209-224	fibroblast growth factor 2	Homo sapiens	20-24
30168023-11	2019	Binding of TSP-2 to FGF2 impaired the growth factor ability to interact with its cellular receptors, since TSP-2-derived fragments prevented the binding of FGF2 to both heparin (used as a structural analog of heparan sulfate proteoglycans) and FGFR-1.	Heparitin Sulfate	209-224	thrombospondin 2	Homo sapiens	107-112
30446119-1	2019	Heparanase, an endo-beta-D-glucuronidase, cleaves cell surface and extracellular matrix heparan sulfate (HS) chains and plays important roles in cellular growth and metastasis.	Heparitin Sulfate	88-103	glucuronidase beta	Homo sapiens	20-40
30446119-1	2019	Heparanase, an endo-beta-D-glucuronidase, cleaves cell surface and extracellular matrix heparan sulfate (HS) chains and plays important roles in cellular growth and metastasis.	Heparitin Sulfate	105-107	glucuronidase beta	Homo sapiens	20-40
30500378-1	2019	Heparan sulfate proteoglycans (HSPG) are macromolecular glyco-conjugates expressed ubiquitously on the cell surface and in the extracellular matrix where they interact with a wide range of ligands to regulate many aspects of cellular function.	Heparitin Sulfate	0-15	syndecan 2	Homo sapiens	31-35
30500378-2	2019	The capacity of the side glycosaminoglycan chain heparan sulfate (HS) being able to interact with diverse protein ligands relies on its complex structure that is generated by a controlled biosynthesis process, involving the actions of glycosyl-transferases, sulfotransferases and the glucuronyl C5-epimerase.	Heparitin Sulfate	49-64	glucuronic acid epimerase	Homo sapiens	284-307
30500378-2	2019	The capacity of the side glycosaminoglycan chain heparan sulfate (HS) being able to interact with diverse protein ligands relies on its complex structure that is generated by a controlled biosynthesis process, involving the actions of glycosyl-transferases, sulfotransferases and the glucuronyl C5-epimerase.	Heparitin Sulfate	66-68	glucuronic acid epimerase	Homo sapiens	284-307
30458230-1	2019	Glucuronyl C5-epimerase (Hsepi) catalyzes the conversion of glucuronic acid to iduronic acid in the process of heparan sulfate biosynthesis.	Heparitin Sulfate	111-126	glucuronyl C5-epimerase	Mus musculus	25-30
30458230-10	2019	The results suggest that Hsepi expression modulates BMP signaling activity, which, at least partially, is associated with defected molecular structure of heparan sulfate expressed in the cells.	Heparitin Sulfate	154-169	glucuronyl C5-epimerase	Mus musculus	25-30
30470661-1	2019	The extracellular sulfatases (Sulfs), sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), have an important role in cell signaling by modulating the 6-O-sulfation of heparan sulfate proteoglycans (HSPGs) on the cell surface.	Heparitin Sulfate	159-174	sulfatase 1	Rattus norvegicus	38-49
30470661-1	2019	The extracellular sulfatases (Sulfs), sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), have an important role in cell signaling by modulating the 6-O-sulfation of heparan sulfate proteoglycans (HSPGs) on the cell surface.	Heparitin Sulfate	159-174	sulfatase 1	Rattus norvegicus	51-56
30470661-1	2019	The extracellular sulfatases (Sulfs), sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), have an important role in cell signaling by modulating the 6-O-sulfation of heparan sulfate proteoglycans (HSPGs) on the cell surface.	Heparitin Sulfate	159-174	sulfatase 2	Rattus norvegicus	62-73
30470661-1	2019	The extracellular sulfatases (Sulfs), sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), have an important role in cell signaling by modulating the 6-O-sulfation of heparan sulfate proteoglycans (HSPGs) on the cell surface.	Heparitin Sulfate	159-174	sulfatase 2	Rattus norvegicus	75-80
30528227-1	2019	BACKGROUND: Sanfilippo syndrome type A (mucopolysaccharidosis type IIIA) is a lysosomal disorder wherein deficient heparan-N-sulfatase (HNS) activity results in the accumulation of heparan sulfate in the central nervous system and is associated with progressive neurodegeneration in early childhood.	Heparitin Sulfate	181-196	N-sulfoglucosamine sulfohydrolase	Homo sapiens	40-71
30579746-6	2019	Osteostimulation of PCL-TCP was enhanced through the addition of a bone matrix-mimicking heparan sulphate glycosaminoglycan (HS3) with increased affinity for bone morphogenetic protein-2 (BMP-2).	Heparitin Sulfate	89-105	bone morphogenetic protein 2	Rattus norvegicus	158-186
30579746-14	2019	CONCLUSION: Enhancing the biomimicry of devices using a heparan sulphate with increased affinity to BMP-2 can serve to improve the performance of PCL-TCP scaffolds and provides a suitable treatment for cranioplasty.	Heparitin Sulfate	56-72	bone morphogenetic protein 2	Rattus norvegicus	100-105
30714949-6	2019	Low creatinine clearance correlated inversely (r = - 0.60) and plasma creatinine directly (r = 0.52) with the two-fold variability in heparan sulfate, which was the only shedding substance that also correlated with C-reactive protein (r = 0.51) and, therefore, showed higher concentrations after surgery.	Heparitin Sulfate	134-149	C-reactive protein	Homo sapiens	215-233
30635159-1	2019	Mucopolysaccharidosis IIIB is caused by a marked decrease in N-acetyl-alpha-d-glucosaminidase (NAGLU) enzyme activity, which leads to the accumulation of heparan sulfate in key organs, progressive brain atrophy, and neurocognitive decline.	Heparitin Sulfate	154-169	N-acetyl-alpha-glucosaminidase	Homo sapiens	61-93
30635159-1	2019	Mucopolysaccharidosis IIIB is caused by a marked decrease in N-acetyl-alpha-d-glucosaminidase (NAGLU) enzyme activity, which leads to the accumulation of heparan sulfate in key organs, progressive brain atrophy, and neurocognitive decline.	Heparitin Sulfate	154-169	N-acetyl-alpha-glucosaminidase	Homo sapiens	95-100
30520531-8	2019	Several of the F-spondin-like domains have insertions in the canonical TSP fold, most notably the coiled coil region in domain 4, which may be utilized in protein-protein binding interactions, suggesting that this protein functions as a heparan sulfate binding site.	Heparitin Sulfate	237-252	thrombospondin 1	Homo sapiens	71-74
30621228-0	2019	Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction.	Heparitin Sulfate	36-51	transglutaminase 2	Homo sapiens	17-35
30621228-3	2019	As the TG2-HSPG interaction is largely mediated by the heparan sulfate (HS) chains of proteoglycans, in the past few years a number of studies have investigated the affinity of TG2 for HS, and the TG2 heparin binding site has been mapped with alternative outlooks.	Heparitin Sulfate	55-70	transglutaminase 2	Homo sapiens	7-10
30621228-3	2019	As the TG2-HSPG interaction is largely mediated by the heparan sulfate (HS) chains of proteoglycans, in the past few years a number of studies have investigated the affinity of TG2 for HS, and the TG2 heparin binding site has been mapped with alternative outlooks.	Heparitin Sulfate	55-70	syndecan 2	Homo sapiens	11-15
30621228-3	2019	As the TG2-HSPG interaction is largely mediated by the heparan sulfate (HS) chains of proteoglycans, in the past few years a number of studies have investigated the affinity of TG2 for HS, and the TG2 heparin binding site has been mapped with alternative outlooks.	Heparitin Sulfate	11-13	transglutaminase 2	Homo sapiens	7-10
30621228-4	2019	In this review, we aim to provide a compendium of the main literature available on the interaction of TG2 with HS, with reference to the pathological processes in which extracellular TG2 plays a role.	Heparitin Sulfate	111-113	transglutaminase 2	Homo sapiens	102-105
30239102-2	2019	Disaccharide analogues of heparan sulfate had previously been identified as the shortest components out of the sugars that bind to FGF-1 and FGF-2.	Heparitin Sulfate	26-41	fibroblast growth factor 1	Homo sapiens	131-136
30239102-2	2019	Disaccharide analogues of heparan sulfate had previously been identified as the shortest components out of the sugars that bind to FGF-1 and FGF-2.	Heparitin Sulfate	26-41	fibroblast growth factor 2	Homo sapiens	141-146
30081189-2	2018	It is caused by mutations in the IDUA gene, which lead to the accumulation of the glycosaminoglycans dermatan and heparan sulfate.	Heparitin Sulfate	114-129	alpha-L-iduronidase	Homo sapiens	33-37
31480068-1	2019	OBJECTIVE: Heparanase (HPA), mammalian endo-beta-d-glucuronidase, separates heparan sulfate chains of proteoglycans and changes the structure of the extracellular matrix.	Heparitin Sulfate	76-91	heparanase	Homo sapiens	11-21
31480068-1	2019	OBJECTIVE: Heparanase (HPA), mammalian endo-beta-d-glucuronidase, separates heparan sulfate chains of proteoglycans and changes the structure of the extracellular matrix.	Heparitin Sulfate	76-91	heparanase	Homo sapiens	23-26
30798810-0	2019	The role of heparin, heparanase and heparan sulfates in hepcidin regulation.	Heparitin Sulfate	36-52	hepcidin antimicrobial peptide	Mus musculus	56-64
30798810-3	2019	Heparin was found to inhibit hepcidin expression and BMP6 activity in hepatic cell lines and in mice, suggesting that endogenous heparan sulfates are involved in the pathway of hepcidin expression.	Heparitin Sulfate	129-145	hepcidin antimicrobial peptide	Mus musculus	29-37
30798810-3	2019	Heparin was found to inhibit hepcidin expression and BMP6 activity in hepatic cell lines and in mice, suggesting that endogenous heparan sulfates are involved in the pathway of hepcidin expression.	Heparitin Sulfate	129-145	bone morphogenetic protein 6	Mus musculus	53-57
30798810-3	2019	Heparin was found to inhibit hepcidin expression and BMP6 activity in hepatic cell lines and in mice, suggesting that endogenous heparan sulfates are involved in the pathway of hepcidin expression.	Heparitin Sulfate	129-145	hepcidin antimicrobial peptide	Mus musculus	177-185
30798810-5	2019	The evidences supporting the role of heparan sulfate in hepcidin expression are summarized in this chapter and open the way for new understanding in hepcidin expression and its control in pathological condition.	Heparitin Sulfate	37-52	hepcidin antimicrobial peptide	Mus musculus	56-64
30798810-5	2019	The evidences supporting the role of heparan sulfate in hepcidin expression are summarized in this chapter and open the way for new understanding in hepcidin expression and its control in pathological condition.	Heparitin Sulfate	37-52	hepcidin antimicrobial peptide	Mus musculus	149-157
30958238-12	2018	Among other results, model-based hypothesis testing predicted lymphatic vessel-dependent concentration of heparan sulfate, the binding partner of CCL21.	Heparitin Sulfate	106-121	C-C motif chemokine ligand 21	Homo sapiens	146-151
29069492-1	2018	Zymogen granule protein 16 (ZG16p) is a soluble lectin that binds to both mannose and heparin/heparan sulfate.	Heparitin Sulfate	94-109	zymogen granule protein 16	Homo sapiens	0-26
30588283-7	2018	One novel potent mechanism is mediated by the heparan sulfate proteoglycan, syndecan-1 (sdc1), which is selectively expressed by IL-17-producing subsets of NKT and gammadelta T cells.	Heparitin Sulfate	46-61	syndecan 1	Mus musculus	76-86
30588283-7	2018	One novel potent mechanism is mediated by the heparan sulfate proteoglycan, syndecan-1 (sdc1), which is selectively expressed by IL-17-producing subsets of NKT and gammadelta T cells.	Heparitin Sulfate	46-61	syndecan 1	Mus musculus	88-92
30588283-7	2018	One novel potent mechanism is mediated by the heparan sulfate proteoglycan, syndecan-1 (sdc1), which is selectively expressed by IL-17-producing subsets of NKT and gammadelta T cells.	Heparitin Sulfate	46-61	interleukin 17A	Mus musculus	129-134
29069492-1	2018	Zymogen granule protein 16 (ZG16p) is a soluble lectin that binds to both mannose and heparin/heparan sulfate.	Heparitin Sulfate	94-109	zymogen granule protein 16	Homo sapiens	28-33
29730503-7	2018	This heparin-induced Fbln7 release was abrogated in CHO-745 cells lacking heparan sulfate proteoglycan or in CHO-K1 cells expressing the Fbln7 mutant lacking the N-terminal coiled-coil domain, suggesting that Fbln7 was tethered to pericellular matrix via this domain.	Heparitin Sulfate	74-89	fibulin-7	Cricetulus griseus	21-26
30487472-1	2018	Heparanase (HPSE) has been defined as a multitasking protein that exhibits a peculiar enzymatic activity towards HS chains but which simultaneously performs other non-enzymatic functions.	Heparitin Sulfate	113-115	heparanase	Homo sapiens	0-10
30487472-1	2018	Heparanase (HPSE) has been defined as a multitasking protein that exhibits a peculiar enzymatic activity towards HS chains but which simultaneously performs other non-enzymatic functions.	Heparitin Sulfate	113-115	heparanase	Homo sapiens	12-16
30487472-2	2018	Through its enzymatic activity, HPSE catalyzes the cutting of the side chains of heparan sulfate (HS) proteoglycans, thus contributing to the remodeling of the extracellular matrix and of the basal membranes.	Heparitin Sulfate	81-96	heparanase	Homo sapiens	32-36
30487472-2	2018	Through its enzymatic activity, HPSE catalyzes the cutting of the side chains of heparan sulfate (HS) proteoglycans, thus contributing to the remodeling of the extracellular matrix and of the basal membranes.	Heparitin Sulfate	98-100	heparanase	Homo sapiens	32-36
30441818-1	2018	The enzyme heparanase, an endo-beta-glucuronidase, degrades heparan sulfate (HS) chains on the cell surface and in the extracellular matrix.	Heparitin Sulfate	60-75	glucuronidase beta	Homo sapiens	31-49
30555321-2	2018	An example of such a moiety is the sulfation at the C3 position of glucosamine residues in HS chain via 3-O sulfotransferase (3-OST) enzymes, which generates a unique virus-cell fusion receptor during herpes simplex virus (HSV) entry and spread.	Heparitin Sulfate	91-93	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	104-124
30555321-2	2018	An example of such a moiety is the sulfation at the C3 position of glucosamine residues in HS chain via 3-O sulfotransferase (3-OST) enzymes, which generates a unique virus-cell fusion receptor during herpes simplex virus (HSV) entry and spread.	Heparitin Sulfate	91-93	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	126-131
30441818-1	2018	The enzyme heparanase, an endo-beta-glucuronidase, degrades heparan sulfate (HS) chains on the cell surface and in the extracellular matrix.	Heparitin Sulfate	77-79	glucuronidase beta	Homo sapiens	31-49
30254073-2	2018	It is now known that the three C-terminal domains of OPG also play essential roles in its function by mediating OPG dimerization, OPG-heparan sulfate (HS) interactions, and formation of the OPG-HS-receptor activator of nuclear factor kappaB ligand (RANKL) ternary complex.	Heparitin Sulfate	134-149	TNF receptor superfamily member 11b	Homo sapiens	53-56
30389911-7	2018	Furthermore, mice injected with syndecan ectodomains, heparan sulfate, and N-desulfated heparin derivatives into periosteal regions of calvaria showed reduction in the formation of tartrate-resistant acid phosphatase (TRAP)-positive mature osteoclasts on the calvarial bone surface, thereby exhibiting decreased bone resorption.	Heparitin Sulfate	54-69	acid phosphatase 5, tartrate resistant	Mus musculus	181-216
30442949-6	2018	Here, we investigated the catch bond interaction between the hydrophilic domain of the human cell surface sulfatase 1 (Sulf1HD) and its physiological substrate heparan sulfate (HS) by atomic force microscopy based single molecule force spectroscopy (AFM-SMFS).	Heparitin Sulfate	160-175	sulfatase 1	Homo sapiens	106-117
30442949-6	2018	Here, we investigated the catch bond interaction between the hydrophilic domain of the human cell surface sulfatase 1 (Sulf1HD) and its physiological substrate heparan sulfate (HS) by atomic force microscopy based single molecule force spectroscopy (AFM-SMFS).	Heparitin Sulfate	177-179	sulfatase 1	Homo sapiens	106-117
30442949-9	2018	Even though structural data of Sulf1HD is lacking, our results allow to draft a detailed picture of the directed and processive desulfation of HS.	Heparitin Sulfate	143-145	sulfatase 1	Homo sapiens	31-36
30389911-6	2018	The inhibitory effects of syndecan ectodomains, heparan sulfate, and N-desulfated heparin derivatives on osteoclast differentiation were attributed to their direct binding to the macrophage-colony stimulating factor (M-CSF), resulting in the blocking of M-CSF-mediated downstream signals such as extracellular signal-regulated kinase (ERK), c-JUN N-terminal kinase (JNK), p38, and Akt.	Heparitin Sulfate	48-63	colony stimulating factor 1	Homo sapiens	179-215
30389911-6	2018	The inhibitory effects of syndecan ectodomains, heparan sulfate, and N-desulfated heparin derivatives on osteoclast differentiation were attributed to their direct binding to the macrophage-colony stimulating factor (M-CSF), resulting in the blocking of M-CSF-mediated downstream signals such as extracellular signal-regulated kinase (ERK), c-JUN N-terminal kinase (JNK), p38, and Akt.	Heparitin Sulfate	48-63	colony stimulating factor 1	Homo sapiens	217-222
30389911-8	2018	Together, these results revealed a novel role of heparan sulfate chains of syndecan ectodomains in the regulation of osteoclast differentiation.	Heparitin Sulfate	49-64	syndecan 1	Homo sapiens	75-83
29978271-1	2018	Mucopolysaccharidosis II (MPS II) is caused by a deficiency of iduronate-2-sulfatase that results in accumulation of glycosaminoglycans (GAG), including heparan sulfate (HS), which is considered to contribute to neuropathology.	Heparitin Sulfate	153-168	iduronate 2-sulfatase	Mus musculus	63-84
29173042-1	2018	Antithrombin (AT) is a serpin that inhibits mainly thrombin and fXa after being activated by binding to glycosaminoglycans as heparin and heparan sulfate.	Heparitin Sulfate	138-153	serpin family C member 1	Homo sapiens	0-12
29173042-1	2018	Antithrombin (AT) is a serpin that inhibits mainly thrombin and fXa after being activated by binding to glycosaminoglycans as heparin and heparan sulfate.	Heparitin Sulfate	138-153	coagulation factor II, thrombin	Homo sapiens	4-12
29173042-1	2018	Antithrombin (AT) is a serpin that inhibits mainly thrombin and fXa after being activated by binding to glycosaminoglycans as heparin and heparan sulfate.	Heparitin Sulfate	138-153	coagulation factor X	Homo sapiens	64-67
29978271-1	2018	Mucopolysaccharidosis II (MPS II) is caused by a deficiency of iduronate-2-sulfatase that results in accumulation of glycosaminoglycans (GAG), including heparan sulfate (HS), which is considered to contribute to neuropathology.	Heparitin Sulfate	170-172	iduronate 2-sulfatase	Mus musculus	63-84
30405705-3	2018	Upon binding to FGF receptors with heparan sulfate as co-factor, FGF10 activates several intracellular signaling cascades, resulting in cell proliferation, differentiation, and invasion.	Heparitin Sulfate	35-50	fibroblast growth factor 10	Homo sapiens	16-19
30425728-5	2018	FGF10 is a typical paracrine FGF and chiefly mediates biological responses by activating FGFR2b with heparin/heparan sulfate (HS) as cofactor.	Heparitin Sulfate	109-124	fibroblast growth factor 10	Mus musculus	0-5
30425728-5	2018	FGF10 is a typical paracrine FGF and chiefly mediates biological responses by activating FGFR2b with heparin/heparan sulfate (HS) as cofactor.	Heparitin Sulfate	109-124	fibroblast growth factor 10	Mus musculus	0-3
30352976-3	2018	The experiments showed that Cu(edtc)2 induced the expression of syndecan-4, a transmembrane heparan sulfate proteoglycan, in a dose- and time-dependent manner.	Heparitin Sulfate	92-107	syndecan 4	Bos taurus	64-74
29458182-8	2018	Based upon mutually exclusive interactions of FGF2 with PI(4,5)P2 versus heparan sulfates, an assembly/disassembly pathway has been proposed to be the underlying principle of directional transport of FGF2 across the plasma membrane.	Heparitin Sulfate	73-89	fibroblast growth factor 2	Homo sapiens	200-204
29458182-9	2018	Thus, the core mechanism of unconventional secretion of FGF2 is based upon three discrete steps with (i) PI(4,5)P2 dependent oligomerization of FGF2 at the inner leaflet, (ii) insertion of membrane spanning FGF2 oligomers into the plasma membrane and (iii) disassembly at the outer leaflet mediated by heparan sulfates that subsequently retain FGF2 on cell surfaces.	Heparitin Sulfate	302-318	fibroblast growth factor 2	Homo sapiens	56-60
30405705-3	2018	Upon binding to FGF receptors with heparan sulfate as co-factor, FGF10 activates several intracellular signaling cascades, resulting in cell proliferation, differentiation, and invasion.	Heparitin Sulfate	35-50	fibroblast growth factor 10	Homo sapiens	65-70
30157624-3	2018	Here, we report a method for remodeling the glycocalyx of mutant Ext1-/- mESCs with defective biosynthesis of HS to drive their mesodermal differentiation in an embryoid body culture.	Heparitin Sulfate	110-112	exostosin glycosyltransferase 1	Mus musculus	65-69
30337538-0	2018	Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility.	Heparitin Sulfate	44-59	MHC I like leukocyte 2	Mus musculus	30-35
30337538-6	2018	Notably, an unusual basic patch on the alpha3 domain is involved in the binding to heparan sulfate which is essential for MILL2 interactions with fibroblasts.	Heparitin Sulfate	83-98	MHC I like leukocyte 2	Mus musculus	122-127
30235481-1	2018	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulphate (HS) chains of proteoglycans (HSPGs).	Heparitin Sulfate	63-79	heparanase	Homo sapiens	0-10
29732534-7	2018	3-O-sulfation of heparan sulfate by HS3ST2 makes ovarian cancer cells intrinsically sensitive to oncogenic signals, which sheds new light on the application of HS3ST2 as a companion diagnostic for targeted therapy using kinase inhibitors or therapeutic antibodies.	Heparitin Sulfate	17-32	heparan sulfate-glucosamine 3-sulfotransferase 2	Homo sapiens	36-42
29732534-7	2018	3-O-sulfation of heparan sulfate by HS3ST2 makes ovarian cancer cells intrinsically sensitive to oncogenic signals, which sheds new light on the application of HS3ST2 as a companion diagnostic for targeted therapy using kinase inhibitors or therapeutic antibodies.	Heparitin Sulfate	17-32	heparan sulfate-glucosamine 3-sulfotransferase 2	Homo sapiens	160-166
30850186-2	2018	As a kind of endo-beta-glucuronidase, heparanase is the known only enzyme in mammals which could degrade heparan sulfate(HS) specifically.	Heparitin Sulfate	105-120	glucuronidase beta	Homo sapiens	18-36
30850186-2	2018	As a kind of endo-beta-glucuronidase, heparanase is the known only enzyme in mammals which could degrade heparan sulfate(HS) specifically.	Heparitin Sulfate	105-120	heparanase	Homo sapiens	38-48
29753267-1	2018	We have previously shown that the heterodimeric cytokine interleukin-12, and the homodimer of its larger subunit p40, both bind to heparin and heparan sulfate with relatively high affinity.	Heparitin Sulfate	143-158	interleukin 9	Homo sapiens	113-116
29579286-1	2018	Background: Mammalian cells express a single functional heparanase, an endoglycosidase that cleaves heparan sulfate and thereby promotes tumor metastasis, angiogenesis, and inflammation.	Heparitin Sulfate	100-115	heparanase	Homo sapiens	56-66
30237293-6	2018	Heparinase-mediated degradation or impaired synthesis of heparan sulfate (HS), a major component of the endothelial glycocalyx, reduces VWF fiber-dependent platelet recruitment.	Heparitin Sulfate	57-72	Von Willebrand factor	Mus musculus	136-139
30237293-6	2018	Heparinase-mediated degradation or impaired synthesis of heparan sulfate (HS), a major component of the endothelial glycocalyx, reduces VWF fiber-dependent platelet recruitment.	Heparitin Sulfate	74-76	Von Willebrand factor	Mus musculus	136-139
30237293-9	2018	In conclusion, we identified HS chains as a relevant binding factor for VWF fibers at the endothelial cell surface in vitro and in vivo.	Heparitin Sulfate	29-31	Von Willebrand factor	Mus musculus	72-75
30248108-0	2018	Differential binding of chemokines CXCL1, CXCL2 and CCL2 to mouse glomerular endothelial cells reveals specificity for distinct heparan sulfate domains.	Heparitin Sulfate	128-143	chemokine (C-X-C motif) ligand 1	Mus musculus	35-40
30248108-0	2018	Differential binding of chemokines CXCL1, CXCL2 and CCL2 to mouse glomerular endothelial cells reveals specificity for distinct heparan sulfate domains.	Heparitin Sulfate	128-143	chemokine (C-X-C motif) ligand 2	Mus musculus	42-47
30248108-0	2018	Differential binding of chemokines CXCL1, CXCL2 and CCL2 to mouse glomerular endothelial cells reveals specificity for distinct heparan sulfate domains.	Heparitin Sulfate	128-143	chemokine (C-C motif) ligand 2	Mus musculus	52-56
30248108-7	2018	We found differential affinities of CXCL1, CXCL2 and CCL2 for HS in isolated mGEnC-1 glycocalyx, heparan sulfate from bovine kidney or low molecular weight heparin in competition ELISAs using mGEnC-1 as a substrate, indicating that chemokine binding is affected by the domain structure of the different HS preparations.	Heparitin Sulfate	97-112	growth-regulated protein homolog alpha	Bos taurus	36-41
30248108-7	2018	We found differential affinities of CXCL1, CXCL2 and CCL2 for HS in isolated mGEnC-1 glycocalyx, heparan sulfate from bovine kidney or low molecular weight heparin in competition ELISAs using mGEnC-1 as a substrate, indicating that chemokine binding is affected by the domain structure of the different HS preparations.	Heparitin Sulfate	97-112	C-C motif chemokine 2	Bos taurus	53-57
30063822-0	2018	Paramagnetic Tag for Glycosylation Sites in Glycoproteins: Structural Constraints on Heparan Sulfate Binding to Robo1.	Heparitin Sulfate	85-100	long intergenic non-protein coding RNA 1194	Homo sapiens	13-16
30235481-1	2018	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulphate (HS) chains of proteoglycans (HSPGs).	Heparitin Sulfate	63-79	heparanase	Homo sapiens	12-16
30063822-0	2018	Paramagnetic Tag for Glycosylation Sites in Glycoproteins: Structural Constraints on Heparan Sulfate Binding to Robo1.	Heparitin Sulfate	85-100	roundabout guidance receptor 1	Homo sapiens	112-117
30235481-1	2018	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulphate (HS) chains of proteoglycans (HSPGs).	Heparitin Sulfate	63-79	glucuronidase beta	Homo sapiens	29-49
30235481-1	2018	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulphate (HS) chains of proteoglycans (HSPGs).	Heparitin Sulfate	81-83	heparanase	Homo sapiens	0-10
30235481-1	2018	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulphate (HS) chains of proteoglycans (HSPGs).	Heparitin Sulfate	81-83	heparanase	Homo sapiens	12-16
30235481-1	2018	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulphate (HS) chains of proteoglycans (HSPGs).	Heparitin Sulfate	81-83	glucuronidase beta	Homo sapiens	29-49
30333909-1	2018	Heparanase (HPSE), a heparan sulfate-specific endo-beta-D-glucuronidase, plays an important role in tumor cell metastasis through the degradation of extracellular matrix heparan sulfate proteoglycans.	Heparitin Sulfate	21-36	heparanase	Homo sapiens	0-10
30333909-1	2018	Heparanase (HPSE), a heparan sulfate-specific endo-beta-D-glucuronidase, plays an important role in tumor cell metastasis through the degradation of extracellular matrix heparan sulfate proteoglycans.	Heparitin Sulfate	21-36	heparanase	Homo sapiens	12-16
30333909-1	2018	Heparanase (HPSE), a heparan sulfate-specific endo-beta-D-glucuronidase, plays an important role in tumor cell metastasis through the degradation of extracellular matrix heparan sulfate proteoglycans.	Heparitin Sulfate	21-36	glucuronidase beta	Homo sapiens	51-71
30082319-0	2018	Domains with highest heparan sulfate-binding affinity reside at opposite ends in BMP2/4 versus BMP5/6/7: Implications for function.	Heparitin Sulfate	21-36	bone morphogenetic protein 2	Homo sapiens	81-87
30082319-0	2018	Domains with highest heparan sulfate-binding affinity reside at opposite ends in BMP2/4 versus BMP5/6/7: Implications for function.	Heparitin Sulfate	21-36	bone morphogenetic protein 5	Homo sapiens	95-103
30100184-4	2018	Mice lacking heparan sulfate (HS) on neurexin-1 show reduced survival, as well as structural and functional deficits at central synapses.	Heparitin Sulfate	13-28	neurexin I	Mus musculus	37-47
30100184-4	2018	Mice lacking heparan sulfate (HS) on neurexin-1 show reduced survival, as well as structural and functional deficits at central synapses.	Heparitin Sulfate	30-32	neurexin I	Mus musculus	37-47
29698813-11	2018	The recent advent of biologicals such as biopolymers mimicking heparan sulfate; coenzyme Q10 and antisense oligonucleotide that suppress connexin 43 expression, all offer promise.	Heparitin Sulfate	63-78	gap junction protein alpha 1	Homo sapiens	137-148
30237860-6	2018	We demonstrated here, that among all cell surface heparan-sulfate proteoglycans, syndecan-4 (SDC4) was essential for cancer cell interaction with ATXbeta but was restrained by heparan-sulfate chains.	Heparitin Sulfate	50-65	syndecan 4	Mus musculus	81-91
30237860-6	2018	We demonstrated here, that among all cell surface heparan-sulfate proteoglycans, syndecan-4 (SDC4) was essential for cancer cell interaction with ATXbeta but was restrained by heparan-sulfate chains.	Heparitin Sulfate	50-65	syndecan 4	Mus musculus	93-97
30064964-1	2018	Mucopolysaccharidosis type II (MPS II or Hunter syndrome) is a lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase (IDS), an enzyme that catabolizes glycosaminoglycans (GAGs) including heparan sulfate (HS) and dermatan sulfate (DS).	Heparitin Sulfate	208-223	iduronate 2-sulfatase	Mus musculus	139-142
30064964-1	2018	Mucopolysaccharidosis type II (MPS II or Hunter syndrome) is a lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase (IDS), an enzyme that catabolizes glycosaminoglycans (GAGs) including heparan sulfate (HS) and dermatan sulfate (DS).	Heparitin Sulfate	225-227	iduronate 2-sulfatase	Mus musculus	139-142
29999301-1	2018	Factor Xa (fXa) inhibition by antithrombin (AT) enabled by heparin or heparan sulfate is critical for controlling blood coagulation.	Heparitin Sulfate	70-85	coagulation factor X	Homo sapiens	0-9
29999301-1	2018	Factor Xa (fXa) inhibition by antithrombin (AT) enabled by heparin or heparan sulfate is critical for controlling blood coagulation.	Heparitin Sulfate	70-85	coagulation factor X	Homo sapiens	11-14
30054430-0	2018	The exostosin family of glycosyltransferases: mRNA expression profiles and heparan sulphate structure in human breast carcinoma cell lines.	Heparitin Sulfate	75-91	exostosin glycosyltransferase 1	Homo sapiens	4-13
30054430-3	2018	The exostosin (EXT) proteins are glycosyltransferases involved in elongation of HS, a regulator of intracellular signaling, cell-cell interactions, and tissue morphogenesis.	Heparitin Sulfate	80-82	exostosin glycosyltransferase 1	Homo sapiens	4-13
30054430-3	2018	The exostosin (EXT) proteins are glycosyltransferases involved in elongation of HS, a regulator of intracellular signaling, cell-cell interactions, and tissue morphogenesis.	Heparitin Sulfate	80-82	exostosin glycosyltransferase 1	Homo sapiens	15-18
29999301-1	2018	Factor Xa (fXa) inhibition by antithrombin (AT) enabled by heparin or heparan sulfate is critical for controlling blood coagulation.	Heparitin Sulfate	70-85	serpin family C member 1	Homo sapiens	30-42
29733455-6	2018	CXCL9(74-103) competes with CXCL6 and CCL3 for binding to the glycosaminoglycans heparan sulfate and chondroitin sulfate in vitro.	Heparitin Sulfate	81-96	chemokine (C-X-C motif) ligand 9	Mus musculus	0-5
29999301-9	2018	The observed post-inhibition binding of heparin to the trapped AT/fXa intermediates hints at the likely role played by heparan sulfate in their catabolism.	Heparitin Sulfate	119-134	coagulation factor X	Homo sapiens	66-69
28288070-11	2018	Pep19-4LF prevented the release of tumor necrosis factor alpha caused by heparan sulfate in human mononuclear cells by binding to this damage-associated molecular pattern.	Heparitin Sulfate	73-88	Purkinje cell protein 4	Homo sapiens	0-5
28288070-11	2018	Pep19-4LF prevented the release of tumor necrosis factor alpha caused by heparan sulfate in human mononuclear cells by binding to this damage-associated molecular pattern.	Heparitin Sulfate	73-88	tumor necrosis factor	Homo sapiens	35-62
29901129-1	2018	Schwartz-Jampel syndrome type 1 (SJS1) is a rare autosomal recessive disease caused by mutations in the gene heparan sulfate proteoglycan 2 (HSPG2; also known as basement membrane-specific heparin sulfate).	Heparitin Sulfate	189-204	heparan sulfate proteoglycan 2	Homo sapiens	109-139
29901129-1	2018	Schwartz-Jampel syndrome type 1 (SJS1) is a rare autosomal recessive disease caused by mutations in the gene heparan sulfate proteoglycan 2 (HSPG2; also known as basement membrane-specific heparin sulfate).	Heparitin Sulfate	189-204	heparan sulfate proteoglycan 2	Homo sapiens	141-146
30082715-7	2018	Furthermore, we identify decreased heparan sulfate levels in Slc10a7-/- mouse cartilage and patient fibroblasts.	Heparitin Sulfate	35-50	solute carrier family 10 (sodium/bile acid cotransporter family), member 7	Mus musculus	61-68
29903730-5	2018	MPO binding to the glycocalyx was further characterized using Chinese hamster ovary cells and its glycosaminoglycan mutants-pgsA-745 (mutant Chinese hamster ovary cells lacking heparan sulfate and chondroitin sulfate glycosaminoglycan) and pgsD-677 (mutant Chinese hamster ovary cells lacking heparan sulfate glycosaminoglycan), which revealed heparan sulfate as the main mediator of MPO binding.	Heparitin Sulfate	177-192	myeloperoxidase	Cricetulus griseus	0-3
29903730-5	2018	MPO binding to the glycocalyx was further characterized using Chinese hamster ovary cells and its glycosaminoglycan mutants-pgsA-745 (mutant Chinese hamster ovary cells lacking heparan sulfate and chondroitin sulfate glycosaminoglycan) and pgsD-677 (mutant Chinese hamster ovary cells lacking heparan sulfate glycosaminoglycan), which revealed heparan sulfate as the main mediator of MPO binding.	Heparitin Sulfate	293-308	myeloperoxidase	Cricetulus griseus	0-3
29903730-11	2018	Conclusions- These findings provide evidence that MPO, via ionic interaction with heparan sulfate side chains, can cause neutrophil-dependent Sdc1 shedding and collapse of the EG structure.	Heparitin Sulfate	82-97	myeloperoxidase	Mus musculus	50-53
29903730-11	2018	Conclusions- These findings provide evidence that MPO, via ionic interaction with heparan sulfate side chains, can cause neutrophil-dependent Sdc1 shedding and collapse of the EG structure.	Heparitin Sulfate	82-97	syndecan 1	Mus musculus	142-146
29733455-6	2018	CXCL9(74-103) competes with CXCL6 and CCL3 for binding to the glycosaminoglycans heparan sulfate and chondroitin sulfate in vitro.	Heparitin Sulfate	81-96	chemokine (C-X-C motif) ligand 5	Mus musculus	28-33
29733455-6	2018	CXCL9(74-103) competes with CXCL6 and CCL3 for binding to the glycosaminoglycans heparan sulfate and chondroitin sulfate in vitro.	Heparitin Sulfate	81-96	chemokine (C-C motif) ligand 3	Mus musculus	38-42
29920400-1	2018	The structure of heparin and heparan sulfate (Hep/HS) oligosaccharides, as determined by the length and the pattern of sulfation, acetylation, and uronic acid epimerization, dictates their biological function through modulating interactions with protein targets.	Heparitin Sulfate	29-44	DNL-type zinc finger	Homo sapiens	46-49
29475023-1	2018	Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a temporal and dynamic fashion.	Heparitin Sulfate	13-28	heparan sulfate proteoglycan 2	Homo sapiens	45-50
29803826-2	2018	Heparanase is the sole mammalian enzyme with HS degrading endoglycosidase activity.	Heparitin Sulfate	45-47	heparanase	Homo sapiens	0-10
28478303-1	2018	Heparanase degrades heparan sulfate in glomerular basement membrane (GBM) and plays an important role in diabetic nephropathy (DN).	Heparitin Sulfate	20-35	heparanase	Mus musculus	0-10
30101150-1	2018	Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB [MPS IIIB]) is a lysosomal storage disorder primarily affecting the brain that is caused by a deficiency in the enzyme alpha-N-acetylglucosaminidase (NAGLU), leading to intralysosomal accumulation of heparan sulfate.	Heparitin Sulfate	260-275	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	179-208
29934346-9	2018	Strikingly, extracellular interactions of PTPsigma with heparan sulfates and Slitrks, intracellular interactions of PTPsigma with liprin-alpha and its associated proteins through the D2 domain, as well as distinct substrates are all critical.	Heparitin Sulfate	56-72	protein tyrosine phosphatase, receptor type, S	Rattus norvegicus	42-50
29669302-1	2018	Hepatocellular carcinoma (HCC) is characterized by elevation in the activity of sulfatase-2, an extracellular enzyme that catalyzes removal of 6-O-sulfate groups from heparan sulfate.	Heparitin Sulfate	167-182	sulfatase 2	Homo sapiens	80-91
29752409-2	2018	We previously reported that tau and alpha-synuclein aggregates bind heparan sulfate proteoglycans (HSPGs) on the cell surface, promoting cellular uptake and intracellular seeding.	Heparitin Sulfate	68-83	microtubule associated protein tau	Homo sapiens	28-31
29752409-2	2018	We previously reported that tau and alpha-synuclein aggregates bind heparan sulfate proteoglycans (HSPGs) on the cell surface, promoting cellular uptake and intracellular seeding.	Heparitin Sulfate	68-83	synuclein alpha	Homo sapiens	36-51
29981367-1	2018	Heparan acetyl CoA: alpha-glucosaminide N-acetyltransferase (HGSNAT) is a lysosomal multi-pass transmembrane protein whose deficiency may lead to an accumulation of heparan sulphate and the neurodegenerative lysosomal storage disorder mucopolysaccharidosis (MPS) IIIC.	Heparitin Sulfate	165-181	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	61-67
29718295-1	2018	The HS3ST3A1/B1 genes encode two homologous 3-O-sulfotransferases involved in the late modification step during heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	112-127	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	Mus musculus	4-12
29420785-2	2018	Both chondroitin sulphate (CS) and heparan sulphate (HS) are important constituents of GAG ligands for RPTPsigma, although they have opposite effects on neuronal cells.	Heparitin Sulfate	35-51	protein tyrosine phosphatase receptor type S	Homo sapiens	103-112
29420785-2	2018	Both chondroitin sulphate (CS) and heparan sulphate (HS) are important constituents of GAG ligands for RPTPsigma, although they have opposite effects on neuronal cells.	Heparitin Sulfate	53-55	protein tyrosine phosphatase receptor type S	Homo sapiens	103-112
28941021-0	2018	Immobilization of vitronectin-binding heparan sulfates onto surfaces to support human pluripotent stem cells.	Heparitin Sulfate	38-54	vitronectin	Homo sapiens	18-29
29420785-4	2018	We prepared recombinant RPTPsigma N-terminal fragment containing the GAG binding site and various types of biotin-conjugated GAG (CS and HS) with chemical modification and chemo-enzymatic synthesis.	Heparitin Sulfate	137-139	protein tyrosine phosphatase receptor type S	Homo sapiens	24-33
28941021-3	2018	In vivo, VN binds the ECM in a sequence-dependent manner with heparan sulfate (HS) glycosaminoglycans.	Heparitin Sulfate	62-77	vitronectin	Homo sapiens	9-11
29940912-8	2018	Regarding the biosynthesis of heparan sulfate chains, differential alterations in transcription depending on the presence or not of metastasis affected genes involved in the modification of uronic acid (epimerization and 2-O sulfation), and some isoforms responsible for sulfation of glucosamine (NDST1, HS6ST1).	Heparitin Sulfate	30-45	N-deacetylase and N-sulfotransferase 1	Homo sapiens	297-302
28941021-8	2018	Compositional analysis demonstrated that 6-O- and N-sulfation, as well as lengths greater than three disaccharide units (dp6) are critical for VN binding to HS-coated surfaces.	Heparitin Sulfate	157-159	vitronectin	Homo sapiens	143-145
29171721-0	2018	Heparan sulfate inhibits inflammation and improves wound healing by downregulating the NLR family pyrin domain containing 3 (NLRP3) inflammasome in diabetic rats.	Heparitin Sulfate	0-15	NLR family, pyrin domain containing 3	Rattus norvegicus	87-123
29171721-0	2018	Heparan sulfate inhibits inflammation and improves wound healing by downregulating the NLR family pyrin domain containing 3 (NLRP3) inflammasome in diabetic rats.	Heparitin Sulfate	0-15	NLR family, pyrin domain containing 3	Rattus norvegicus	125-130
29171721-10	2018	CONCLUSIONS: Heparan sulfate inhibits inflammation and improves wound healing by downregulating the NLRP3 inflammasome and cleaved IL-1beta during the wound healing process in diabetic rats.	Heparitin Sulfate	13-28	NLR family, pyrin domain containing 3	Rattus norvegicus	100-105
29171721-10	2018	CONCLUSIONS: Heparan sulfate inhibits inflammation and improves wound healing by downregulating the NLRP3 inflammasome and cleaved IL-1beta during the wound healing process in diabetic rats.	Heparitin Sulfate	13-28	interleukin 1 beta	Rattus norvegicus	131-139
29955035-1	2018	Heparanase is an endo-beta-glucuronidase that specifically cleaves the saccharide chains of heparan sulfate (HS) proteoglycans and releases HS-bound cytokines, chemokines, and bioactive growth-promoting factors.	Heparitin Sulfate	92-107	glucuronidase beta	Homo sapiens	22-40
30042881-1	2018	The aim of this study was to determine the role of the perlecan (Hspg2) heparan sulphate (HS) side chains on cell and matrix homeostasis in tail and Achilles tendons in 3 and 12 week old Hspg2 exon 3 null HS deficient (Hspg2Delta3 - /Delta3 -) and C57 BL/6 Wild Type (WT) mice.	Heparitin Sulfate	72-88	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	65-70
30042881-1	2018	The aim of this study was to determine the role of the perlecan (Hspg2) heparan sulphate (HS) side chains on cell and matrix homeostasis in tail and Achilles tendons in 3 and 12 week old Hspg2 exon 3 null HS deficient (Hspg2Delta3 - /Delta3 -) and C57 BL/6 Wild Type (WT) mice.	Heparitin Sulfate	90-92	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	65-70
29940912-8	2018	Regarding the biosynthesis of heparan sulfate chains, differential alterations in transcription depending on the presence or not of metastasis affected genes involved in the modification of uronic acid (epimerization and 2-O sulfation), and some isoforms responsible for sulfation of glucosamine (NDST1, HS6ST1).	Heparitin Sulfate	30-45	heparan sulfate 6-O-sulfotransferase 1	Homo sapiens	304-310
29700203-8	2018	In the anterior stomach, loss of epithelial HS leads to stratification and differentiation defects of the multilayered squamous epithelium, along with reduced Hh and Bmp signaling activity.	Heparitin Sulfate	44-46	bone morphogenetic protein 1	Homo sapiens	166-169
29904116-4	2018	Breast cancer cells depleted of heparan sulfate or chondroitin sulfate glycosaminoglycans lose their ability to induce APRIL secretion from neutrophils, and heparan sulfate and chondroitin sulfate can induce secretion that is comparable to that of breast cancer cell-induced secretion.	Heparitin Sulfate	32-47	TNF superfamily member 13	Homo sapiens	119-124
29904116-6	2018	Thus, apart from the putative role of cell surface heparan sulfate in binding APRIL that leads to cell growth, we demonstrate that heparan sulfate, as well as chondroitin sulfate plays a novel role in promoting neutrophil secretion of APRIL that could lead to further cell growth.	Heparitin Sulfate	51-66	TNF superfamily member 13	Homo sapiens	78-83
29904116-6	2018	Thus, apart from the putative role of cell surface heparan sulfate in binding APRIL that leads to cell growth, we demonstrate that heparan sulfate, as well as chondroitin sulfate plays a novel role in promoting neutrophil secretion of APRIL that could lead to further cell growth.	Heparitin Sulfate	131-146	TNF superfamily member 13	Homo sapiens	235-240
29904116-7	2018	We propose that breast cancer cells take advantage of the neutrophil recruitment to the tumor microenvironment through the dual role of heparan sulfate as cell surface receptor or docking molecule for APRIL and as a ligand that induces neutrophil APRIL secretion to promote their own growth.	Heparitin Sulfate	136-151	TNF superfamily member 13	Homo sapiens	201-206
29904116-7	2018	We propose that breast cancer cells take advantage of the neutrophil recruitment to the tumor microenvironment through the dual role of heparan sulfate as cell surface receptor or docking molecule for APRIL and as a ligand that induces neutrophil APRIL secretion to promote their own growth.	Heparitin Sulfate	136-151	TNF superfamily member 13	Homo sapiens	247-252
29580921-0	2018	Potential role for Ext1-dependent heparan sulfate in regulating P311 gene expression in A549 carcinoma cells.	Heparitin Sulfate	34-49	exostosin glycosyltransferase 1	Mus musculus	19-23
29580921-0	2018	Potential role for Ext1-dependent heparan sulfate in regulating P311 gene expression in A549 carcinoma cells.	Heparitin Sulfate	34-49	neuronal regeneration related protein	Mus musculus	64-68
29580921-1	2018	BACKGROUND: Exostosin-1 (EXT1), a member of the EXT protein family, is indispensable for synthesis of heparan sulfate (HS) chains that bind to and modulate the signaling efficiency of numerous growth factor activities.	Heparitin Sulfate	102-117	exostosin glycosyltransferase 1	Mus musculus	12-23
29580921-1	2018	BACKGROUND: Exostosin-1 (EXT1), a member of the EXT protein family, is indispensable for synthesis of heparan sulfate (HS) chains that bind to and modulate the signaling efficiency of numerous growth factor activities.	Heparitin Sulfate	102-117	exostosin glycosyltransferase 1	Mus musculus	25-29
29580921-1	2018	BACKGROUND: Exostosin-1 (EXT1), a member of the EXT protein family, is indispensable for synthesis of heparan sulfate (HS) chains that bind to and modulate the signaling efficiency of numerous growth factor activities.	Heparitin Sulfate	119-121	exostosin glycosyltransferase 1	Mus musculus	12-23
29580921-1	2018	BACKGROUND: Exostosin-1 (EXT1), a member of the EXT protein family, is indispensable for synthesis of heparan sulfate (HS) chains that bind to and modulate the signaling efficiency of numerous growth factor activities.	Heparitin Sulfate	119-121	exostosin glycosyltransferase 1	Mus musculus	25-29
29580921-9	2018	GENERAL SIGNIFICANCE: This study considers a possible novel mechanism of Ext1-regulated heparan sulfate structure in modifying tumor-stroma interactions through altering stromal tgf-ss1 expression.	Heparitin Sulfate	88-103	exostosin glycosyltransferase 1	Mus musculus	73-77
29924795-12	2018	Four week-old Nphs1 knockout mice subjected to protamine sulfate model of podocyte injury demonstrated failure to recover from foot process effacement following heparin sulfate.	Heparitin Sulfate	161-176	nephrosis 1, nephrin	Mus musculus	14-19
29545125-2	2018	MO has been linked to mutations in either EXT1 or EXT2, two glycosyltransferases required for the synthesis of heparan sulfate (HS).	Heparitin Sulfate	111-126	exostosin glycosyltransferase 1	Homo sapiens	42-46
29545125-2	2018	MO has been linked to mutations in either EXT1 or EXT2, two glycosyltransferases required for the synthesis of heparan sulfate (HS).	Heparitin Sulfate	111-126	exostosin glycosyltransferase 2	Homo sapiens	50-54
29545125-2	2018	MO has been linked to mutations in either EXT1 or EXT2, two glycosyltransferases required for the synthesis of heparan sulfate (HS).	Heparitin Sulfate	128-130	exostosin glycosyltransferase 1	Homo sapiens	42-46
29545125-2	2018	MO has been linked to mutations in either EXT1 or EXT2, two glycosyltransferases required for the synthesis of heparan sulfate (HS).	Heparitin Sulfate	128-130	exostosin glycosyltransferase 2	Homo sapiens	50-54
29520710-0	2018	A Traveling Wave Ion Mobility Spectrometry (TWIMS) Study of the Robo1-Heparan Sulfate Interaction.	Heparitin Sulfate	70-85	roundabout guidance receptor 1	Homo sapiens	64-69
29520710-3	2018	Previous studies suggest that HS is required to promote the binding of Robo1 to Slit to form the minimal signaling complex, but the molecular details and the structural requirements of HS for this interaction are still unclear.	Heparitin Sulfate	30-32	roundabout guidance receptor 1	Homo sapiens	71-76
29520710-5	2018	The results suggest that Robo1 exists in two conformations that differ by their compactness and capability to interact with HS.	Heparitin Sulfate	124-126	roundabout guidance receptor 1	Homo sapiens	25-30
29520710-9	2018	Furthermore, the effect of N-glycosylation on the conformation of Robo1 and its binding modes with HS is reported.	Heparitin Sulfate	99-101	roundabout guidance receptor 1	Homo sapiens	66-71
29496505-8	2018	Also, hypoxia decreased both the number of Cuprolinic blue-positive glycosaminoglycan chains along collagen fibrils and Sulfatase 1, which modulates the effect of heparan sulfate by removing the 6-O-sulfate groups.	Heparitin Sulfate	163-178	sulfatase 1	Homo sapiens	120-131
29773865-1	2018	Perlecan (HSPG2), a heparan sulfate proteoglycan, is a component of basement membranes and participates in a variety of biological activities.	Heparitin Sulfate	20-35	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	10-15
29686391-0	2018	Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).	Heparitin Sulfate	53-68	microtubule associated protein tau	Homo sapiens	0-3
29462330-0	2018	Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.	Heparitin Sulfate	88-104	chondroitin sulfate proteoglycan 4	Homo sapiens	13-48
29462330-0	2018	Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.	Heparitin Sulfate	88-104	chondroitin sulfate proteoglycan 4	Homo sapiens	50-55
29471321-1	2018	Heparanase, an endo-glucuronidase that specifically cleaves heparan sulfate (HS), is upregulated in several pathological conditions.	Heparitin Sulfate	60-75	heparanase	Mus musculus	0-10
29471321-1	2018	Heparanase, an endo-glucuronidase that specifically cleaves heparan sulfate (HS), is upregulated in several pathological conditions.	Heparitin Sulfate	77-79	heparanase	Mus musculus	0-10
29686391-4	2018	Using CRISPRi technology we have tested 3200 genes for their ability to regulate tau entry and identified enzymes in the heparan sulfate proteoglycan biosynthetic pathway as key regulators.	Heparitin Sulfate	121-136	microtubule associated protein tau	Homo sapiens	81-84
29523771-1	2018	Syndecan-1 (Sdc1) is a major cell surface heparan sulfate (HS) proteoglycan of epithelial cells, a cell type targeted by many bacterial pathogens early in their pathogenesis.	Heparitin Sulfate	42-57	syndecan 1	Mus musculus	0-10
29523771-1	2018	Syndecan-1 (Sdc1) is a major cell surface heparan sulfate (HS) proteoglycan of epithelial cells, a cell type targeted by many bacterial pathogens early in their pathogenesis.	Heparitin Sulfate	42-57	syndecan 1	Mus musculus	12-16
29570275-2	2018	Glycosaminoglycan chains, including heparan sulfate (HS) and chondroitin sulfate (CS), act as ligands that regulate LAR signaling.	Heparitin Sulfate	36-51	protein tyrosine phosphatase receptor type F	Homo sapiens	116-119
29523771-1	2018	Syndecan-1 (Sdc1) is a major cell surface heparan sulfate (HS) proteoglycan of epithelial cells, a cell type targeted by many bacterial pathogens early in their pathogenesis.	Heparitin Sulfate	59-61	syndecan 1	Mus musculus	0-10
29570275-2	2018	Glycosaminoglycan chains, including heparan sulfate (HS) and chondroitin sulfate (CS), act as ligands that regulate LAR signaling.	Heparitin Sulfate	53-55	protein tyrosine phosphatase receptor type F	Homo sapiens	116-119
29523771-1	2018	Syndecan-1 (Sdc1) is a major cell surface heparan sulfate (HS) proteoglycan of epithelial cells, a cell type targeted by many bacterial pathogens early in their pathogenesis.	Heparitin Sulfate	59-61	syndecan 1	Mus musculus	12-16
29541207-5	2018	Mutations to exostosin-1 (EXT1) and EXT2 mutations cause insufficient heparan sulfate biosynthesis, leading to chondrocyte proliferation, abnormal bone growth in neighboring regions, multiple exostoses, and ultimately malignant transformation.	Heparitin Sulfate	70-85	exostosin glycosyltransferase 1	Homo sapiens	13-24
29305908-2	2018	Thus, changes in the amounts, structures, and chain lengths of heparan sulfate have profound effects on aspects of cell growth controlled by heparin-binding growth factors such as FGF2.	Heparitin Sulfate	63-78	fibroblast growth factor 2	Mus musculus	180-184
29305908-3	2018	Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate.	Heparitin Sulfate	77-92	exostosin glycosyltransferase 1	Mus musculus	32-36
29305908-3	2018	Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate.	Heparitin Sulfate	77-92	exostosin glycosyltransferase 2	Mus musculus	38-42
29305908-3	2018	Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate.	Heparitin Sulfate	77-92	exostosin-like glycosyltransferase 1	Mus musculus	44-49
29305908-3	2018	Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate.	Heparitin Sulfate	77-92	exostosin-like glycosyltransferase 2	Mus musculus	51-56
29305908-3	2018	Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate.	Heparitin Sulfate	77-92	exostosin-like glycosyltransferase 3	Mus musculus	62-67
29305908-3	2018	Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate.	Heparitin Sulfate	211-226	exostosin glycosyltransferase 1	Mus musculus	32-36
29305908-3	2018	Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate.	Heparitin Sulfate	211-226	exostosin glycosyltransferase 2	Mus musculus	38-42
29305908-3	2018	Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate.	Heparitin Sulfate	211-226	exostosin-like glycosyltransferase 1	Mus musculus	44-49
29305908-3	2018	Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate.	Heparitin Sulfate	211-226	exostosin-like glycosyltransferase 2	Mus musculus	51-56
29305908-3	2018	Exostosin glycosyltransferases (EXT1, EXT2, EXTL1, EXTL2, and EXTL3) control heparan sulfate biosynthesis, and the expression levels of their genes regulate the amounts, chain lengths, and sulfation patterns of heparan sulfate.	Heparitin Sulfate	211-226	exostosin-like glycosyltransferase 3	Mus musculus	62-67
29305908-4	2018	Unlike EXT1, EXT2, and EXTL3, EXTL2 functions chain termination of heparan sulfate.	Heparitin Sulfate	67-82	exostosin-like glycosyltransferase 2	Mus musculus	30-35
29120519-2	2018	The large majority of patients with MHE carry loss-of-function mutations in the EXT1 or EXT2 gene, which encodes a glycosyltransferase essential for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	149-164	exostosin glycosyltransferase 1	Homo sapiens	80-84
29120519-2	2018	The large majority of patients with MHE carry loss-of-function mutations in the EXT1 or EXT2 gene, which encodes a glycosyltransferase essential for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	149-164	exostosin glycosyltransferase 2	Homo sapiens	88-92
29414779-0	2018	Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.	Heparitin Sulfate	104-119	neurturin	Homo sapiens	68-77
29414779-0	2018	Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.	Heparitin Sulfate	104-119	GDNF family receptor alpha 2	Homo sapiens	78-83
29414779-6	2018	We have identified a heparan sulfate-binding site on NRTN and a putative binding site in GFRa2, suggesting that heparan sulfate has a role in the assembly of the signaling complex.	Heparitin Sulfate	21-36	neurturin	Homo sapiens	53-57
29414779-6	2018	We have identified a heparan sulfate-binding site on NRTN and a putative binding site in GFRa2, suggesting that heparan sulfate has a role in the assembly of the signaling complex.	Heparitin Sulfate	112-127	neurturin	Homo sapiens	53-57
29414779-6	2018	We have identified a heparan sulfate-binding site on NRTN and a putative binding site in GFRa2, suggesting that heparan sulfate has a role in the assembly of the signaling complex.	Heparitin Sulfate	112-127	GDNF family receptor alpha 2	Homo sapiens	89-94
29414779-7	2018	We further show that mutant NRTN with reduced affinity for heparan sulfate may provide a route forward for delivery of NRTN with increased exposure in preclinical in vivo models and ultimately to Parkinson"s patients.	Heparitin Sulfate	59-74	neurturin	Homo sapiens	28-32
29414779-7	2018	We further show that mutant NRTN with reduced affinity for heparan sulfate may provide a route forward for delivery of NRTN with increased exposure in preclinical in vivo models and ultimately to Parkinson"s patients.	Heparitin Sulfate	59-74	neurturin	Homo sapiens	119-123
29305908-7	2018	RESULTS: Reduced expression of either EXT1, EXT2, or EXTL3 decreased heparan sulfate biosynthesis, and consequently suppressed the FGF2-dependent proliferation of mouse L fibroblasts.	Heparitin Sulfate	69-84	exostosin glycosyltransferase 1	Mus musculus	38-42
29305908-7	2018	RESULTS: Reduced expression of either EXT1, EXT2, or EXTL3 decreased heparan sulfate biosynthesis, and consequently suppressed the FGF2-dependent proliferation of mouse L fibroblasts.	Heparitin Sulfate	69-84	exostosin glycosyltransferase 2	Mus musculus	44-48
29305908-7	2018	RESULTS: Reduced expression of either EXT1, EXT2, or EXTL3 decreased heparan sulfate biosynthesis, and consequently suppressed the FGF2-dependent proliferation of mouse L fibroblasts.	Heparitin Sulfate	69-84	exostosin-like glycosyltransferase 3	Mus musculus	53-58
29305908-8	2018	In contrast, although knockdown of EXTL2 increased the amounts of heparan sulfate, FGF2-dependent proliferation was significantly inhibited because the increased heparan sulfate enhanced the incorporation of FGF2 into the cells.	Heparitin Sulfate	66-81	exostosin-like glycosyltransferase 2	Mus musculus	35-40
29305908-8	2018	In contrast, although knockdown of EXTL2 increased the amounts of heparan sulfate, FGF2-dependent proliferation was significantly inhibited because the increased heparan sulfate enhanced the incorporation of FGF2 into the cells.	Heparitin Sulfate	162-177	exostosin-like glycosyltransferase 2	Mus musculus	35-40
29305908-8	2018	In contrast, although knockdown of EXTL2 increased the amounts of heparan sulfate, FGF2-dependent proliferation was significantly inhibited because the increased heparan sulfate enhanced the incorporation of FGF2 into the cells.	Heparitin Sulfate	162-177	fibroblast growth factor 2	Mus musculus	83-87
29305908-8	2018	In contrast, although knockdown of EXTL2 increased the amounts of heparan sulfate, FGF2-dependent proliferation was significantly inhibited because the increased heparan sulfate enhanced the incorporation of FGF2 into the cells.	Heparitin Sulfate	162-177	fibroblast growth factor 2	Mus musculus	208-212
29305908-9	2018	CONCLUSIONS: EXTL2 controls FGF2 signaling through regulation of heparan sulfate biosynthesis in a manner distinct from that of other exostosins.	Heparitin Sulfate	65-80	exostosin-like glycosyltransferase 2	Mus musculus	13-18
29305908-9	2018	CONCLUSIONS: EXTL2 controls FGF2 signaling through regulation of heparan sulfate biosynthesis in a manner distinct from that of other exostosins.	Heparitin Sulfate	65-80	fibroblast growth factor 2	Mus musculus	28-32
29330473-2	2018	Our previous studies demonstrated that, during acute inflammation, endothelial heparan sulfate (HS) contributes to the adhesion and transendothelial migration of leukocytes into perivascular tissues by direct interaction with L-selectin and the presentation of bound chemokines.	Heparitin Sulfate	79-94	selectin, lymphocyte	Mus musculus	226-236
29330473-2	2018	Our previous studies demonstrated that, during acute inflammation, endothelial heparan sulfate (HS) contributes to the adhesion and transendothelial migration of leukocytes into perivascular tissues by direct interaction with L-selectin and the presentation of bound chemokines.	Heparitin Sulfate	96-98	selectin, lymphocyte	Mus musculus	226-236
29330473-4	2018	To reduce sulfation of HS specifically in the endothelium, we generated Ndst1 f/f Tie2Cre + mice in which N-deacetylase/N-sulfotransferase-1 (Ndst1), the gene that initiates HS sulfation modifications in HS biosynthesis, was expressly ablated in endothelium.	Heparitin Sulfate	174-176	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	106-140
29541207-5	2018	Mutations to exostosin-1 (EXT1) and EXT2 mutations cause insufficient heparan sulfate biosynthesis, leading to chondrocyte proliferation, abnormal bone growth in neighboring regions, multiple exostoses, and ultimately malignant transformation.	Heparitin Sulfate	70-85	exostosin glycosyltransferase 1	Homo sapiens	26-30
29541207-5	2018	Mutations to exostosin-1 (EXT1) and EXT2 mutations cause insufficient heparan sulfate biosynthesis, leading to chondrocyte proliferation, abnormal bone growth in neighboring regions, multiple exostoses, and ultimately malignant transformation.	Heparitin Sulfate	70-85	exostosin glycosyltransferase 2	Homo sapiens	36-40
29518031-7	2018	The delivery mechanism involves lipid-raft-mediated endocytosis following heparan sulfate interaction; d-Iduna-EGFP was localized in the nucleus as well as the cytoplasm, and its residence time was much longer than that of other controls such as TAT and Hph-1.	Heparitin Sulfate	74-89	ring finger protein 146	Homo sapiens	105-110
29616016-9	2018	In conclusion, using this novel Medical-In silico approach, our data suggest (i) that HS induces necroptosis in cardiomyocytes by phosphorylation (activation) of receptor-interacting protein 3, (ii) that HS is a therapeutic target in trauma- or sepsis-associated cardiomyopathy, and (iii) indicate that this proof-of-concept is a first step toward simulating the extent of activated components in the pro-apoptotic pathway induced by HS with only a small data set gained from the in vitro experiments by using machine learning algorithms.	Heparitin Sulfate	86-88	receptor-interacting serine-threonine kinase 3	Mus musculus	162-192
29616016-9	2018	In conclusion, using this novel Medical-In silico approach, our data suggest (i) that HS induces necroptosis in cardiomyocytes by phosphorylation (activation) of receptor-interacting protein 3, (ii) that HS is a therapeutic target in trauma- or sepsis-associated cardiomyopathy, and (iii) indicate that this proof-of-concept is a first step toward simulating the extent of activated components in the pro-apoptotic pathway induced by HS with only a small data set gained from the in vitro experiments by using machine learning algorithms.	Heparitin Sulfate	204-206	receptor-interacting serine-threonine kinase 3	Mus musculus	162-192
29408503-0	2018	Common traffic routes for imported spermine and endosomal glypican-1-derived heparan sulfate in fibroblasts.	Heparitin Sulfate	77-92	glypican 1	Mus musculus	58-68
29408503-6	2018	The antibodies used were specific for spermine, glypican-1-derived heparan sulfate, Rab7, nucleolin and a marker for autophagosomes.	Heparitin Sulfate	67-82	glypican 1	Mus musculus	48-58
29408503-9	2018	When ascorbate was added, heparan sulfate and spermine were transported to the nucleus where they colocalized with nucleolin.	Heparitin Sulfate	26-41	nucleolin	Mus musculus	115-124
29408503-12	2018	During the chase, when arrest was abolished, heparan sulfate and spermine were both transported to the nucleus and targeted nucleolin.	Heparitin Sulfate	45-60	nucleolin	Mus musculus	124-133
29203543-8	2018	Ultimately, by employing mouse strains resistant or susceptible to chronic VVC, it was determined that heparan sulfate (HS) in the vaginal environment of susceptible mice serves as a competitive ligand for Mac-1 on PMNs, which effectively renders the PMNs incapable of binding to Candida to initiate killing.	Heparitin Sulfate	103-118	integrin alpha M	Mus musculus	206-211
29222072-0	2018	Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression.	Heparitin Sulfate	0-15	vascular cell adhesion molecule 1	Rattus norvegicus	82-88
29222072-0	2018	Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression.	Heparitin Sulfate	0-15	intercellular adhesion molecule 1	Rattus norvegicus	93-99
29222072-2	2018	Cardiac injury involves the release of various damage-associated molecular patterns (DAMPs) including heparan sulfate (HS), a constituent of the extracellular matrix (ECM), through the TLR4 receptor activation triggering a strong inflammatory response, inducing leukocytes recruitment.	Heparitin Sulfate	102-117	toll-like receptor 4	Rattus norvegicus	185-189
29222072-2	2018	Cardiac injury involves the release of various damage-associated molecular patterns (DAMPs) including heparan sulfate (HS), a constituent of the extracellular matrix (ECM), through the TLR4 receptor activation triggering a strong inflammatory response, inducing leukocytes recruitment.	Heparitin Sulfate	119-121	toll-like receptor 4	Rattus norvegicus	185-189
29346724-3	2018	The exostosin (EXT) proteins are glycosyltransferases in the Golgi apparatus that assemble HS chains on HSPGs.	Heparitin Sulfate	91-93	exostosin glycosyltransferase 1	Homo sapiens	4-13
29346724-3	2018	The exostosin (EXT) proteins are glycosyltransferases in the Golgi apparatus that assemble HS chains on HSPGs.	Heparitin Sulfate	91-93	exostosin glycosyltransferase 1	Homo sapiens	15-18
29346724-4	2018	The EXTL3 enzyme mainly works as an initiator in HS biosynthesis.	Heparitin Sulfate	49-51	exostosin like glycosyltransferase 3	Homo sapiens	4-9
29212806-3	2018	Expression of the heparan sulfate (HS) proteoglycan syndecan-1 is a hallmark of MM.	Heparitin Sulfate	18-33	syndecan 1	Homo sapiens	52-62
29212806-3	2018	Expression of the heparan sulfate (HS) proteoglycan syndecan-1 is a hallmark of MM.	Heparitin Sulfate	35-37	syndecan 1	Homo sapiens	52-62
29203543-8	2018	Ultimately, by employing mouse strains resistant or susceptible to chronic VVC, it was determined that heparan sulfate (HS) in the vaginal environment of susceptible mice serves as a competitive ligand for Mac-1 on PMNs, which effectively renders the PMNs incapable of binding to Candida to initiate killing.	Heparitin Sulfate	120-122	integrin alpha M	Mus musculus	206-211
29415886-0	2018	Osteoblastic heparan sulfate regulates osteoprotegerin function and bone mass.	Heparitin Sulfate	13-28	TNF receptor superfamily member 11b	Homo sapiens	39-54
29453458-6	2018	Inhibited ITK expression did not affect the CXCR4 receptor on the cell surface, whereas CD4 and LFA-1 integrin levels were slightly enhanced in ITK knockdown cells and heparan sulfate (HS) expression was completely abolished in ITK depleted T-cells.	Heparitin Sulfate	168-183	IL2 inducible T cell kinase	Homo sapiens	144-147
29453458-6	2018	Inhibited ITK expression did not affect the CXCR4 receptor on the cell surface, whereas CD4 and LFA-1 integrin levels were slightly enhanced in ITK knockdown cells and heparan sulfate (HS) expression was completely abolished in ITK depleted T-cells.	Heparitin Sulfate	168-183	IL2 inducible T cell kinase	Homo sapiens	144-147
29449596-0	2018	Heparan sulfates facilitate harmless amyloidogenic fibril formation interacting with elastin-like peptides.	Heparitin Sulfate	0-16	elastin	Homo sapiens	85-92
29449596-1	2018	Heparan sulfates (HSs) modulate tissue elasticity in physiopathological conditions by interacting with various matrix constituents as tropoelastin and elastin-derived peptides.	Heparitin Sulfate	0-16	elastin	Homo sapiens	134-146
29237830-10	2018	Axl-mediated LASV entry is facilitated by heparan sulfate and critically depends on the late endosomal protein LAMP-1 as an intracellular entry factor.	Heparitin Sulfate	42-57	AXL receptor tyrosine kinase	Homo sapiens	0-3
29251941-2	2018	Mutations in the SGSH enzyme, the only mammalian heparan N-sulfatase, cause accumulation of lysosomal inclusion bodies in brain cells comprising heparan sulfate (HS) glycosaminoglycans (GAGs).	Heparitin Sulfate	145-160	N-sulfoglucosamine sulfohydrolase	Homo sapiens	17-21
29449596-1	2018	Heparan sulfates (HSs) modulate tissue elasticity in physiopathological conditions by interacting with various matrix constituents as tropoelastin and elastin-derived peptides.	Heparitin Sulfate	0-16	elastin	Homo sapiens	139-146
29449596-1	2018	Heparan sulfates (HSs) modulate tissue elasticity in physiopathological conditions by interacting with various matrix constituents as tropoelastin and elastin-derived peptides.	Heparitin Sulfate	18-21	elastin	Homo sapiens	134-146
29449596-1	2018	Heparan sulfates (HSs) modulate tissue elasticity in physiopathological conditions by interacting with various matrix constituents as tropoelastin and elastin-derived peptides.	Heparitin Sulfate	18-21	elastin	Homo sapiens	139-146
29288051-7	2018	CD spectral changes of SAA (1-76) peptide but not full-length SAA were observed when incubated with HS, although the spectrum was not typical for a beta-structure.	Heparitin Sulfate	100-102	serum amyloid A1 cluster	Homo sapiens	23-26
29342138-6	2018	Dimerization of the stabilized ternary complexes and receptor activation remain dependent on the binding of heparan sulfate, a mandatory cofactor of paracrine FGF signalling.	Heparitin Sulfate	108-123	fibroblast growth factor 23	Homo sapiens	159-162
29348482-1	2018	Mucopolysaccharidosis (MPS) IIIB is an inherited lysosomal storage disease caused by the deficiency of the enzyme alpha-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation.	Heparitin Sulfate	165-180	N-acetyl-alpha-glucosaminidase	Rattus norvegicus	114-143
29348482-1	2018	Mucopolysaccharidosis (MPS) IIIB is an inherited lysosomal storage disease caused by the deficiency of the enzyme alpha-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation.	Heparitin Sulfate	165-180	N-acetyl-alpha-glucosaminidase	Rattus norvegicus	145-150
29348482-1	2018	Mucopolysaccharidosis (MPS) IIIB is an inherited lysosomal storage disease caused by the deficiency of the enzyme alpha-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation.	Heparitin Sulfate	182-184	N-acetyl-alpha-glucosaminidase	Rattus norvegicus	114-143
29348482-1	2018	Mucopolysaccharidosis (MPS) IIIB is an inherited lysosomal storage disease caused by the deficiency of the enzyme alpha-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation.	Heparitin Sulfate	182-184	N-acetyl-alpha-glucosaminidase	Rattus norvegicus	145-150
29288051-4	2018	In the present study, we examined the effect of C-terminal truncation on amyloid fibril formation of human SAA induced by heparan sulfate (HS).	Heparitin Sulfate	122-137	serum amyloid A1 cluster	Homo sapiens	107-110
29288051-4	2018	In the present study, we examined the effect of C-terminal truncation on amyloid fibril formation of human SAA induced by heparan sulfate (HS).	Heparitin Sulfate	139-141	serum amyloid A1 cluster	Homo sapiens	107-110
29392318-10	2018	ciChEnCs synthesized glycosaminoglycans chondroitin sulfate and the complement factor H ligand heparan sulfate.	Heparitin Sulfate	95-110	complement factor H	Homo sapiens	79-87
29399340-1	2018	Cell surface heparan sulfate (HS) proteoglycans interact with other extracellular matrix (ECM) components, and HS-binding regions are present in ECM proteins such as fibronectin and fibrillin.	Heparitin Sulfate	13-28	fibronectin 1	Homo sapiens	166-177
30107380-2	2018	Specific heparan sulfate structures enhance the HGF/Met signaling at both cell and animal-based model systems.	Heparitin Sulfate	9-24	hepatocyte growth factor	Cricetulus griseus	48-51
29186350-2	2018	Absence of NAGLU leads to accumulation of partially degraded heparan sulphate within lysosomes and the extracellular matrix, giving rise to severe CNS degeneration with progressive cognitive impairment and behavioural problems.	Heparitin Sulfate	61-77	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	11-16
29186350-11	2018	LV.NAGLU treatment led to behavioural correction, normalization of heparan sulphate and sulphation patterning, reduced inflammatory cytokine expression and correction of astrocytosis, microgliosis and lysosomal compartment size throughout the brain.	Heparitin Sulfate	67-83	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	3-8
29316553-6	2018	RESULTS: Disruption of Gas6 expression led to the inhibition of HS biosynthesis through the reduction of several HS biosynthetic enzymes.	Heparitin Sulfate	64-66	growth arrest specific 6	Mus musculus	23-27
29316553-6	2018	RESULTS: Disruption of Gas6 expression led to the inhibition of HS biosynthesis through the reduction of several HS biosynthetic enzymes.	Heparitin Sulfate	113-115	growth arrest specific 6	Mus musculus	23-27
30107380-3	2018	Biochemical studies indicate that heparan sulfate interacts with HGF and a natural occurring splicing variant NK1 of HGF with similar affinity.	Heparitin Sulfate	34-49	hepatocyte growth factor	Cricetulus griseus	65-68
30107380-3	2018	Biochemical studies indicate that heparan sulfate interacts with HGF and a natural occurring splicing variant NK1 of HGF with similar affinity.	Heparitin Sulfate	34-49	hepatocyte growth factor	Cricetulus griseus	117-120
28864123-5	2018	In parallel, we also increased glucose concentration and supplied heparan sulfate to avoid depletion of glucose and bFGF, respectively.	Heparitin Sulfate	66-81	fibroblast growth factor 2	Homo sapiens	116-120
28836185-1	2018	BACKGROUND: In the severe neurodegenerative disorder mucopolysaccharidosis type IIIB (MPSIIIB or Sanfilippo disease type B), deficiency of the lysosomal enzyme N-acetyl-alpha-glucosaminidase (NAGLU) results in accumulation of heparan sulfate.	Heparitin Sulfate	226-241	N-acetyl-alpha-glucosaminidase	Homo sapiens	160-190
28893506-0	2017	Cytochrome b561, copper, beta-cleaved amyloid precursor protein and niemann-pick C1 protein are involved in ascorbate-induced release and membrane penetration of heparan sulfate from endosomal S-nitrosylated glypican-1.	Heparitin Sulfate	162-177	glypican 1	Homo sapiens	208-218
29671225-2	2018	Deficiency of the lysosomal enzyme, iduronate-2-sulfatase (EC 3.1.6.13) results in deposition of the glycosaminoglycans, dermatan, and heparan sulfate in various tissues.	Heparitin Sulfate	135-150	iduronate 2-sulfatase	Homo sapiens	36-57
29158323-2	2017	The glycosaminoglycan heparan sulphate (HS) binds to FGFs and exists in an enormous number of differentially sulphated forms produced by the action of HS modifying enzymes, and so has the potential to present an extremely large amount of information in FGF/ERK signalling.	Heparitin Sulfate	40-42	mitogen-activated protein kinase 1	Mus musculus	257-260
29215008-4	2017	N-sulfo-rich HS is frequently internalized and associated with the signaling vesicle, known as the Frizzled/Wnt/LRP6 signalosome, in the presence of Wnt8.	Heparitin Sulfate	13-15	LDL receptor related protein 6 L homeolog	Xenopus laevis	112-116
29215008-4	2017	N-sulfo-rich HS is frequently internalized and associated with the signaling vesicle, known as the Frizzled/Wnt/LRP6 signalosome, in the presence of Wnt8.	Heparitin Sulfate	13-15	Wnt family member 8A L homeolog	Xenopus laevis	149-153
29215008-5	2017	Conversely, N-acetyl-rich HS is rarely internalized and accumulates Frzb, a secreted Wnt antagonist.	Heparitin Sulfate	26-28	frzb	Xenopus laevis	68-72
29215008-7	2017	Thus, these two types of HS clusters may constitute a cellular platform for the distribution and signaling of Wnt8.	Heparitin Sulfate	25-27	Wnt family member 8A L homeolog	Xenopus laevis	110-114
28893506-1	2017	Ascorbate-induced release of heparan sulfate from S-nitrosylated heparan sulfate proteoglycan glypican-1 takes place in endosomes.	Heparitin Sulfate	29-44	glypican 1	Homo sapiens	94-104
28893506-12	2017	Re-oxidation of copper (I) is coupled to reductive, deaminative release of heparan sulfate from glypican-1.	Heparitin Sulfate	75-90	glypican 1	Homo sapiens	96-106
29125867-12	2017	Our findings indicate that CXCR4 activation attenuates thrombin-induced lung endothelial barrier function impairment and suggest that protective effects of CXCL12 are dictated by its CXCR4 agonist activity and interactions of distinct protein moieties with heparan sulfate on the endothelial surface.	Heparitin Sulfate	257-272	C-X-C motif chemokine ligand 12	Homo sapiens	156-162
28837800-5	2017	MCP-1 inhibition, however, increased glomerular endothelial glycocalyx coverage, with preservation of heparan sulfate.	Heparitin Sulfate	102-117	chemokine (C-C motif) ligand 2	Mus musculus	0-5
29125867-12	2017	Our findings indicate that CXCR4 activation attenuates thrombin-induced lung endothelial barrier function impairment and suggest that protective effects of CXCL12 are dictated by its CXCR4 agonist activity and interactions of distinct protein moieties with heparan sulfate on the endothelial surface.	Heparitin Sulfate	257-272	C-X-C motif chemokine receptor 4	Homo sapiens	27-32
28657777-3	2017	By removing 6-O-sulfates from specific heparan sulfate intrachain sites, Sulf2 modulates the functions of many growth factors and cytokines.	Heparitin Sulfate	39-54	sulfatase 2	Mus musculus	73-78
29016740-1	2017	Aims: Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI).	Heparitin Sulfate	51-66	fibroblast growth factor 1	Homo sapiens	6-32
28206697-4	2017	Among the different enzymes playing a role in such changes, heparanase-1 is responsible for cleaving heparan sulfate (HS) at a limited number of sites, clearly involved in tissue remodeling.	Heparitin Sulfate	101-116	heparanase	Homo sapiens	60-72
28206697-4	2017	Among the different enzymes playing a role in such changes, heparanase-1 is responsible for cleaving heparan sulfate (HS) at a limited number of sites, clearly involved in tissue remodeling.	Heparitin Sulfate	118-120	heparanase	Homo sapiens	60-72
28799166-5	2017	Membrane-inserted FGF2 oligomers are dynamic translocation intermediates that are disassembled at the extracellular leaflet mediated by membrane proximal heparan sulphate proteoglycans.	Heparitin Sulfate	154-170	fibroblast growth factor 2	Homo sapiens	18-22
29016740-1	2017	Aims: Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI).	Heparitin Sulfate	51-66	fibroblast growth factor 1	Homo sapiens	34-38
28126521-1	2017	The HS3ST1 gene controls endothelial cell production of HSAT+ - a form of heparan sulfate containing a specific pentasaccharide motif that binds the anticoagulant protein antithrombin (AT).	Heparitin Sulfate	74-89	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	Mus musculus	4-10
28888201-2	2017	The sCMC component in the hydrogel served the purpose of mimicking heparan sulfate and thus enabled strong binding with TGF-beta1 and its consequential long term presentation to the encapsulated cells.	Heparitin Sulfate	67-82	transforming growth factor beta 1	Homo sapiens	120-129
28126521-1	2017	The HS3ST1 gene controls endothelial cell production of HSAT+ - a form of heparan sulfate containing a specific pentasaccharide motif that binds the anticoagulant protein antithrombin (AT).	Heparitin Sulfate	74-89	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	171-183
29104277-0	2017	Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation.	Heparitin Sulfate	0-15	exostosin glycosyltransferase 1	Homo sapiens	72-78
28474284-5	2017	This review focuses on the interactions and contribution to the pathogenesis and progression of OA through the DAMPs: high-mobility group box 1 (HMGB-1), the receptor for advanced glycation end-products (RAGE), the alarmin proteins S100A8 and S100A9, and heparan sulfate.	Heparitin Sulfate	255-270	high mobility group box 1	Homo sapiens	145-151
29104277-0	2017	Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation.	Heparitin Sulfate	0-15	heparan sulfate 6-O-sulfotransferase 1	Homo sapiens	83-89
29062064-0	2017	Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.	Heparitin Sulfate	15-30	sulfatase 1	Mus musculus	34-39
29062064-0	2017	Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.	Heparitin Sulfate	15-30	sulfatase 2	Mus musculus	44-49
29062064-2	2017	Here we report a novel mechanism in which extracellular removal of 6-O-sulfate groups from HS by the endosulfatases, Sulf1 and Sulf2, is essential for axon guidance during development.	Heparitin Sulfate	91-93	sulfatase 1	Mus musculus	117-122
29062064-2	2017	Here we report a novel mechanism in which extracellular removal of 6-O-sulfate groups from HS by the endosulfatases, Sulf1 and Sulf2, is essential for axon guidance during development.	Heparitin Sulfate	91-93	sulfatase 2	Mus musculus	127-132
29085061-3	2017	We found that cell surface binding and internalization of 3D8 scFv were inhibited markedly in soluble heparan sulfate (HS)/chondroitin sulfate (CS)-deficient or -removed cells and in the presence of soluble HS and CS.	Heparitin Sulfate	102-117	immunglobulin heavy chain variable region	Homo sapiens	62-66
29085061-3	2017	We found that cell surface binding and internalization of 3D8 scFv were inhibited markedly in soluble heparan sulfate (HS)/chondroitin sulfate (CS)-deficient or -removed cells and in the presence of soluble HS and CS.	Heparitin Sulfate	119-121	immunglobulin heavy chain variable region	Homo sapiens	62-66
29085061-3	2017	We found that cell surface binding and internalization of 3D8 scFv were inhibited markedly in soluble heparan sulfate (HS)/chondroitin sulfate (CS)-deficient or -removed cells and in the presence of soluble HS and CS.	Heparitin Sulfate	207-209	immunglobulin heavy chain variable region	Homo sapiens	62-66
29023478-7	2017	With intact HS, 60% of EC borders expressed Cx43 and dye spread to 2.88 +- 0.09 neighboring cells.	Heparitin Sulfate	12-14	gap junction protein alpha 1	Homo sapiens	44-48
28474284-9	2017	Heparan sulfate has been shown to facilitate the binding of HMGB-1 to RAGE and could play a role in the progression of OA.	Heparitin Sulfate	0-15	high mobility group box 1	Homo sapiens	60-66
28474284-9	2017	Heparan sulfate has been shown to facilitate the binding of HMGB-1 to RAGE and could play a role in the progression of OA.	Heparitin Sulfate	0-15	advanced glycosylation end-product specific receptor	Homo sapiens	70-74
29070611-7	2017	Starting with four sets of 254 HS tetrasaccharides, we identified 25 sequences that bind to CXCL13 monomer, among which a single one bound to CXCL13 dimer with high consistency.	Heparitin Sulfate	31-33	C-X-C motif chemokine ligand 13	Homo sapiens	92-98
29070611-7	2017	Starting with four sets of 254 HS tetrasaccharides, we identified 25 sequences that bind to CXCL13 monomer, among which a single one bound to CXCL13 dimer with high consistency.	Heparitin Sulfate	31-33	C-X-C motif chemokine ligand 13	Homo sapiens	142-148
29070611-9	2017	Consistently, we designed CXCL13 mutations that preclude interaction with HS without affecting CXCR5-dependent cell signalling, opening the possibility to unambiguously demonstrate the role of HS in the biological function of this chemokine.	Heparitin Sulfate	74-76	C-X-C motif chemokine ligand 13	Homo sapiens	26-32
29070611-9	2017	Consistently, we designed CXCL13 mutations that preclude interaction with HS without affecting CXCR5-dependent cell signalling, opening the possibility to unambiguously demonstrate the role of HS in the biological function of this chemokine.	Heparitin Sulfate	193-195	C-X-C motif chemokine ligand 13	Homo sapiens	26-32
28894089-0	2017	Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.	Heparitin Sulfate	0-15	proprotein convertase subtilisin/kexin type 9	Homo sapiens	38-43
28927006-5	2017	In mammals, heparanase (HPSE) is the only known enzyme capable of regulating HS functions via a selective endoglycosidase activity that cleaves polymeric HS chains at internal sites.	Heparitin Sulfate	77-79	heparanase	Homo sapiens	12-22
28927006-5	2017	In mammals, heparanase (HPSE) is the only known enzyme capable of regulating HS functions via a selective endoglycosidase activity that cleaves polymeric HS chains at internal sites.	Heparitin Sulfate	77-79	heparanase	Homo sapiens	24-28
28778449-1	2017	Heparanase is a heparan sulfate degrading enzyme that cleaves heparan sulfate (HS) chains present on HS proteoglycans (HSPGs), and has been well characterized for its roles in tumor metastasis and inflammation.	Heparitin Sulfate	16-31	heparanase	Homo sapiens	0-10
28778449-1	2017	Heparanase is a heparan sulfate degrading enzyme that cleaves heparan sulfate (HS) chains present on HS proteoglycans (HSPGs), and has been well characterized for its roles in tumor metastasis and inflammation.	Heparitin Sulfate	62-77	heparanase	Homo sapiens	0-10
28778449-1	2017	Heparanase is a heparan sulfate degrading enzyme that cleaves heparan sulfate (HS) chains present on HS proteoglycans (HSPGs), and has been well characterized for its roles in tumor metastasis and inflammation.	Heparitin Sulfate	79-81	heparanase	Homo sapiens	0-10
28734894-1	2017	d-Glucuronyl C5-epimerase (GLCE) is one of key enzymes in heparan sulfate biosynthesis and possesses tumour-suppressor function in breast carcinogenesis.	Heparitin Sulfate	58-73	glucuronic acid epimerase	Homo sapiens	0-25
28734894-1	2017	d-Glucuronyl C5-epimerase (GLCE) is one of key enzymes in heparan sulfate biosynthesis and possesses tumour-suppressor function in breast carcinogenesis.	Heparitin Sulfate	58-73	glucuronic acid epimerase	Homo sapiens	27-31
28955044-1	2017	Cell penetrating peptide derived from human eosinophil cationic protein (CPPecp) is a 10-amino-acid peptide containing a core heparan sulfate (HS)-binding motif of human eosinophil cationic protein (ECP).	Heparitin Sulfate	126-141	ribonuclease A family member 3	Homo sapiens	44-71
28955044-1	2017	Cell penetrating peptide derived from human eosinophil cationic protein (CPPecp) is a 10-amino-acid peptide containing a core heparan sulfate (HS)-binding motif of human eosinophil cationic protein (ECP).	Heparitin Sulfate	126-141	ribonuclease A family member 3	Homo sapiens	170-197
28955044-1	2017	Cell penetrating peptide derived from human eosinophil cationic protein (CPPecp) is a 10-amino-acid peptide containing a core heparan sulfate (HS)-binding motif of human eosinophil cationic protein (ECP).	Heparitin Sulfate	143-145	ribonuclease A family member 3	Homo sapiens	44-71
28955044-1	2017	Cell penetrating peptide derived from human eosinophil cationic protein (CPPecp) is a 10-amino-acid peptide containing a core heparan sulfate (HS)-binding motif of human eosinophil cationic protein (ECP).	Heparitin Sulfate	143-145	ribonuclease A family member 3	Homo sapiens	170-197
28955044-1	2017	Cell penetrating peptide derived from human eosinophil cationic protein (CPPecp) is a 10-amino-acid peptide containing a core heparan sulfate (HS)-binding motif of human eosinophil cationic protein (ECP).	Heparitin Sulfate	143-145	ribonuclease A family member 3	Homo sapiens	199-202
28894089-4	2017	The heparan sulfate-binding site is located in the PCSK9 prodomain and formed by surface-exposed basic residues interacting with trisulfated heparan sulfate disaccharide repeats.	Heparitin Sulfate	4-19	proprotein convertase subtilisin/kexin type 9	Homo sapiens	51-56
28894089-5	2017	Accordingly, heparan sulfate mimetics and monoclonal antibodies directed against the heparan sulfate-binding site are potent PCSK9 inhibitors.	Heparitin Sulfate	13-28	proprotein convertase subtilisin/kexin type 9	Homo sapiens	125-130
28894089-5	2017	Accordingly, heparan sulfate mimetics and monoclonal antibodies directed against the heparan sulfate-binding site are potent PCSK9 inhibitors.	Heparitin Sulfate	85-100	proprotein convertase subtilisin/kexin type 9	Homo sapiens	125-130
28894089-6	2017	We propose that heparan sulfate proteoglycans lining the hepatocyte surface capture PCSK9 and facilitates subsequent PCSK9:LDLR complex formation.	Heparitin Sulfate	16-31	proprotein convertase subtilisin/kexin type 9	Homo sapiens	84-89
28894089-6	2017	We propose that heparan sulfate proteoglycans lining the hepatocyte surface capture PCSK9 and facilitates subsequent PCSK9:LDLR complex formation.	Heparitin Sulfate	16-31	proprotein convertase subtilisin/kexin type 9	Homo sapiens	117-122
28894089-0	2017	Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.	Heparitin Sulfate	0-15	low density lipoprotein receptor	Homo sapiens	51-63
28894089-6	2017	We propose that heparan sulfate proteoglycans lining the hepatocyte surface capture PCSK9 and facilitates subsequent PCSK9:LDLR complex formation.	Heparitin Sulfate	16-31	low density lipoprotein receptor	Homo sapiens	123-127
28894089-7	2017	Our findings provide new insights into LDL biology and show that targeting PCSK9 using heparan sulfate mimetics is a potential therapeutic strategy in coronary artery disease.PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL.	Heparitin Sulfate	87-102	proprotein convertase subtilisin/kexin type 9	Homo sapiens	75-80
28894089-7	2017	Our findings provide new insights into LDL biology and show that targeting PCSK9 using heparan sulfate mimetics is a potential therapeutic strategy in coronary artery disease.PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL.	Heparitin Sulfate	87-102	proprotein convertase subtilisin/kexin type 9	Homo sapiens	175-180
28894089-7	2017	Our findings provide new insights into LDL biology and show that targeting PCSK9 using heparan sulfate mimetics is a potential therapeutic strategy in coronary artery disease.PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL.	Heparitin Sulfate	87-102	low density lipoprotein receptor	Homo sapiens	196-208
28389983-8	2017	The present work comprehensively investigates the efficacy of these ions for assigning the C-5 stereochemistry of the reducing end uronic acid in 33 HS tetrasaccharides.	Heparitin Sulfate	149-151	complement C5	Homo sapiens	91-94
28601604-3	2017	This disorder results from a mutation in the gene encoding the lysosomal sulphatase sulphamidase, and as a consequence heparan sulphate accumulates, accompanied by secondarily-stored gangliosides.	Heparitin Sulfate	119-135	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	84-96
28751108-1	2017	BACKGROUND: The autosomal recessive, neurodegenerative disorder mucopolysaccharidosis type IIIB (MPSIIIB) is caused by a deficiency of the lysosomal enzyme N-acetyl-alpha-glucosaminidase (NAGLU), resulting in accumulation of heparan sulfate.	Heparitin Sulfate	225-240	N-acetyl-alpha-glucosaminidase	Homo sapiens	156-186
28751108-1	2017	BACKGROUND: The autosomal recessive, neurodegenerative disorder mucopolysaccharidosis type IIIB (MPSIIIB) is caused by a deficiency of the lysosomal enzyme N-acetyl-alpha-glucosaminidase (NAGLU), resulting in accumulation of heparan sulfate.	Heparitin Sulfate	225-240	N-acetyl-alpha-glucosaminidase	Homo sapiens	188-193
28827536-0	2017	Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type.	Heparitin Sulfate	71-86	synuclein alpha	Homo sapiens	28-43
28859094-3	2017	Herein, we show that epithelial deletion of Heparan Sulfate (HS) synthetase Ext1 resulted in expanded branching tips and reduced branching number, associated with several mesenchymal developmental defects.	Heparitin Sulfate	44-59	exostosin glycosyltransferase 1	Homo sapiens	76-80
28859094-3	2017	Herein, we show that epithelial deletion of Heparan Sulfate (HS) synthetase Ext1 resulted in expanded branching tips and reduced branching number, associated with several mesenchymal developmental defects.	Heparitin Sulfate	61-63	exostosin glycosyltransferase 1	Homo sapiens	76-80
28859141-8	2017	The glycosaminoglycan content and structure in Aspn-/- skin was profoundly altered: chondroitin/dermatan sulfate was more than doubled and had an altered composition, while heparan sulfate was halved and had a decreased sulfation.	Heparitin Sulfate	173-188	asporin	Mus musculus	47-51
28827536-4	2017	We show, using a pH-sensitive probe, that internalization of alpha-synuclein amyloid fibrils in neuroblastoma cells is dependent on heparan sulfate, whereas internalization of smaller non-amyloid oligomers is not.	Heparitin Sulfate	132-147	synuclein alpha	Homo sapiens	61-76
28827536-5	2017	We also show that alpha-synuclein fibril uptake in an oligodendrocyte-like cell line is equally dependent on heparan sulfate, while astrocyte- and microglia-like cell lines have other means to internalize the fibrils.	Heparitin Sulfate	109-124	synuclein alpha	Homo sapiens	18-33
28827536-6	2017	In addition, we analyzed the interaction between the alpha-synuclein amyloid fibrils and heparan sulfate and show that overall sulfation of the heparan sulfate chains is more important than sulfation at particular sites along the chains.	Heparitin Sulfate	89-104	synuclein alpha	Homo sapiens	53-68
28827536-6	2017	In addition, we analyzed the interaction between the alpha-synuclein amyloid fibrils and heparan sulfate and show that overall sulfation of the heparan sulfate chains is more important than sulfation at particular sites along the chains.	Heparitin Sulfate	144-159	synuclein alpha	Homo sapiens	53-68
28448806-3	2017	EXT-1 is essential for heparan sulphate synthesis, which may play a role in the dentin mineralization.	Heparitin Sulfate	23-39	exostosin glycosyltransferase 1	Homo sapiens	0-5
28739923-3	2017	Glypican-2 (GPC2) is a cell surface heparan sulfate proteoglycan that is important for neuronal cell adhesion and neurite outgrowth.	Heparitin Sulfate	36-51	glypican 2	Homo sapiens	0-10
28739923-3	2017	Glypican-2 (GPC2) is a cell surface heparan sulfate proteoglycan that is important for neuronal cell adhesion and neurite outgrowth.	Heparitin Sulfate	36-51	glypican 2	Homo sapiens	12-16
28813681-2	2017	To dissect the molecular basis for this functional pleiotropy, we engineered an FGF1 partial agonist carrying triple mutations (FGF1DeltaHBS) that diminished its ability to induce heparan sulfate (HS)-assisted FGF receptor (FGFR) dimerization and activation.	Heparitin Sulfate	180-195	fibroblast growth factor 1	Homo sapiens	80-84
28813681-2	2017	To dissect the molecular basis for this functional pleiotropy, we engineered an FGF1 partial agonist carrying triple mutations (FGF1DeltaHBS) that diminished its ability to induce heparan sulfate (HS)-assisted FGF receptor (FGFR) dimerization and activation.	Heparitin Sulfate	197-199	fibroblast growth factor 1	Homo sapiens	80-84
28768899-2	2017	Although it has been well established that MHE is caused by mutations in EXT1 and EXT2, which encode glycosyltransferase essential for heparan sulfate (HS) biosynthesis, the cellular origin and molecular mechanisms of MHE remain elusive.	Heparitin Sulfate	135-150	exostosin glycosyltransferase 1	Mus musculus	73-77
28768899-2	2017	Although it has been well established that MHE is caused by mutations in EXT1 and EXT2, which encode glycosyltransferase essential for heparan sulfate (HS) biosynthesis, the cellular origin and molecular mechanisms of MHE remain elusive.	Heparitin Sulfate	135-150	exostosin glycosyltransferase 2	Mus musculus	82-86
28768899-2	2017	Although it has been well established that MHE is caused by mutations in EXT1 and EXT2, which encode glycosyltransferase essential for heparan sulfate (HS) biosynthesis, the cellular origin and molecular mechanisms of MHE remain elusive.	Heparitin Sulfate	135-150	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	101-120
28768899-2	2017	Although it has been well established that MHE is caused by mutations in EXT1 and EXT2, which encode glycosyltransferase essential for heparan sulfate (HS) biosynthesis, the cellular origin and molecular mechanisms of MHE remain elusive.	Heparitin Sulfate	152-154	exostosin glycosyltransferase 1	Mus musculus	73-77
28768899-2	2017	Although it has been well established that MHE is caused by mutations in EXT1 and EXT2, which encode glycosyltransferase essential for heparan sulfate (HS) biosynthesis, the cellular origin and molecular mechanisms of MHE remain elusive.	Heparitin Sulfate	152-154	exostosin glycosyltransferase 2	Mus musculus	82-86
28768899-2	2017	Although it has been well established that MHE is caused by mutations in EXT1 and EXT2, which encode glycosyltransferase essential for heparan sulfate (HS) biosynthesis, the cellular origin and molecular mechanisms of MHE remain elusive.	Heparitin Sulfate	152-154	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	101-120
28478695-1	2017	Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is a rare X-linked recessive lysosomal disorder caused by defective iduronate-2-sulfatase (IDS), resulting in accumulation of heparan sulfate and dermatan sulfate glycosaminoglycans (GAGs).	Heparitin Sulfate	182-197	iduronate 2-sulfatase	Mus musculus	147-150
28596239-6	2017	Furthermore, Slit2, a chemorepulsive ligand, was identified to be colocalized with HS in forming a ligand gradient across cellular membranes.	Heparitin Sulfate	83-85	slit guidance ligand 2	Homo sapiens	13-18
28019669-2	2017	Previously, we reported that transforming growth factor-beta1 (TGF-beta1 ) regulates the synthesis of a large heparan sulfate proteoglycan, perlecan, and a small leucine-rich dermatan sulfate proteoglycan, biglycan, in vascular endothelial cells depending on cell density.	Heparitin Sulfate	110-125	transforming growth factor beta 1	Bos taurus	29-61
28019669-2	2017	Previously, we reported that transforming growth factor-beta1 (TGF-beta1 ) regulates the synthesis of a large heparan sulfate proteoglycan, perlecan, and a small leucine-rich dermatan sulfate proteoglycan, biglycan, in vascular endothelial cells depending on cell density.	Heparitin Sulfate	110-125	transforming growth factor beta 1	Bos taurus	63-72
28211170-3	2017	Shear stress induces the remodelling of the major component of the glycocalyx including glypican-1, a cell membrane heparan sulphate proteoglycan.	Heparitin Sulfate	116-132	glypican 1	Homo sapiens	88-98
28629128-1	2017	FGF-1 is a potent mitogen that, by interacting simultaneously with Heparan Sulfate Glycosaminoglycan HSGAG and the extracellular domains of its membrane receptor (FGFR), generates an intracellular signal that finally leads to cell division.	Heparitin Sulfate	67-82	fibroblast growth factor 1	Homo sapiens	0-5
28547849-4	2017	We previously found that fractones capture and store fibroblast growth factor 2 (FGF-2) via heparan sulfate binding, and may deliver FGF-2 to neural stem cells in a timely manner.	Heparitin Sulfate	92-107	fibroblast growth factor 2	Homo sapiens	53-79
28547849-4	2017	We previously found that fractones capture and store fibroblast growth factor 2 (FGF-2) via heparan sulfate binding, and may deliver FGF-2 to neural stem cells in a timely manner.	Heparitin Sulfate	92-107	fibroblast growth factor 2	Homo sapiens	81-86
28722655-6	2017	Vectorial translocation of FGF2 across the membrane is governed by sequential and mutually exclusive interactions with PI(4,5)P2 and heparan sulfates on opposing sides of the membrane.	Heparitin Sulfate	133-149	fibroblast growth factor 2	Homo sapiens	27-31
28064160-2	2017	Heparanase (HPSE), an endoglycosidase that cleaves heparan sulfate chains, is involved in the EMT of several cell lines, and may have a major role in this pro-fibrotic process potentially responsible for the failure of dialysis.	Heparitin Sulfate	51-66	heparanase	Homo sapiens	0-10
28064160-2	2017	Heparanase (HPSE), an endoglycosidase that cleaves heparan sulfate chains, is involved in the EMT of several cell lines, and may have a major role in this pro-fibrotic process potentially responsible for the failure of dialysis.	Heparitin Sulfate	51-66	heparanase	Homo sapiens	12-16
28690282-4	2017	EXT1 and EXT2 genes encode exostosin 1 and exostosin 2, respectively, both of which are transmembrane glycosyltransferases that elongate the chains of heparin sulfate (HS) at HS proteoglycans (HSPGs).	Heparitin Sulfate	151-166	exostosin glycosyltransferase 1	Homo sapiens	0-4
28690282-4	2017	EXT1 and EXT2 genes encode exostosin 1 and exostosin 2, respectively, both of which are transmembrane glycosyltransferases that elongate the chains of heparin sulfate (HS) at HS proteoglycans (HSPGs).	Heparitin Sulfate	151-166	exostosin glycosyltransferase 2	Homo sapiens	9-13
28690282-4	2017	EXT1 and EXT2 genes encode exostosin 1 and exostosin 2, respectively, both of which are transmembrane glycosyltransferases that elongate the chains of heparin sulfate (HS) at HS proteoglycans (HSPGs).	Heparitin Sulfate	151-166	exostosin glycosyltransferase 1	Homo sapiens	27-38
28690282-4	2017	EXT1 and EXT2 genes encode exostosin 1 and exostosin 2, respectively, both of which are transmembrane glycosyltransferases that elongate the chains of heparin sulfate (HS) at HS proteoglycans (HSPGs).	Heparitin Sulfate	151-166	exostosin glycosyltransferase 2	Homo sapiens	43-54
28690282-4	2017	EXT1 and EXT2 genes encode exostosin 1 and exostosin 2, respectively, both of which are transmembrane glycosyltransferases that elongate the chains of heparin sulfate (HS) at HS proteoglycans (HSPGs).	Heparitin Sulfate	168-170	exostosin glycosyltransferase 1	Homo sapiens	0-4
28690282-4	2017	EXT1 and EXT2 genes encode exostosin 1 and exostosin 2, respectively, both of which are transmembrane glycosyltransferases that elongate the chains of heparin sulfate (HS) at HS proteoglycans (HSPGs).	Heparitin Sulfate	168-170	exostosin glycosyltransferase 2	Homo sapiens	9-13
28690282-4	2017	EXT1 and EXT2 genes encode exostosin 1 and exostosin 2, respectively, both of which are transmembrane glycosyltransferases that elongate the chains of heparin sulfate (HS) at HS proteoglycans (HSPGs).	Heparitin Sulfate	168-170	exostosin glycosyltransferase 1	Homo sapiens	27-38
28690282-4	2017	EXT1 and EXT2 genes encode exostosin 1 and exostosin 2, respectively, both of which are transmembrane glycosyltransferases that elongate the chains of heparin sulfate (HS) at HS proteoglycans (HSPGs).	Heparitin Sulfate	168-170	exostosin glycosyltransferase 2	Homo sapiens	43-54
28331220-4	2017	Although these phenotypes overlap considerably with some known SEMDs, they had a novel causal gene, exostosin-like glycosyltransferase 3 (EXTL3), that encodes a glycosyltransferase involved in the synthesis of heparin and heparan sulfate.	Heparitin Sulfate	222-237	exostosin like glycosyltransferase 3	Homo sapiens	100-136
28331220-4	2017	Although these phenotypes overlap considerably with some known SEMDs, they had a novel causal gene, exostosin-like glycosyltransferase 3 (EXTL3), that encodes a glycosyltransferase involved in the synthesis of heparin and heparan sulfate.	Heparitin Sulfate	222-237	exostosin like glycosyltransferase 3	Homo sapiens	138-143
28747756-5	2017	Combinatorial ECMs composed of collagen IV + heparan sulfate + laminin (CHL) or collagen IV + gelatin + heparan sulfate (CGH) demonstrated significantly higher expression of CD31, compared to single-factor ECMs.	Heparitin Sulfate	45-60	platelet and endothelial cell adhesion molecule 1	Homo sapiens	174-178
28747756-5	2017	Combinatorial ECMs composed of collagen IV + heparan sulfate + laminin (CHL) or collagen IV + gelatin + heparan sulfate (CGH) demonstrated significantly higher expression of CD31, compared to single-factor ECMs.	Heparitin Sulfate	104-119	platelet and endothelial cell adhesion molecule 1	Homo sapiens	174-178
29100299-2	2017	NT4 peptides specifically bind to lipoprotein receptor-related proteins (LRP) receptors and to heparan sulfate chains on membrane proteoglycans and can be efficiently internalized by cancer cells expressing these membrane targets.	Heparitin Sulfate	95-110	neurotrophin 4	Homo sapiens	0-3
28672878-2	2017	As the exact composition of the heparan sulfate portion of the resulting HSPG molecules is critical to the broad spectrum of biological processes involved in oncogenesis, the epigenetic regulation of heparan sulfate biosynthesis has far-reaching effects on many cellular activities related to cancer progression.	Heparitin Sulfate	32-47	syndecan 2	Homo sapiens	73-77
28672878-2	2017	As the exact composition of the heparan sulfate portion of the resulting HSPG molecules is critical to the broad spectrum of biological processes involved in oncogenesis, the epigenetic regulation of heparan sulfate biosynthesis has far-reaching effects on many cellular activities related to cancer progression.	Heparitin Sulfate	200-215	syndecan 2	Homo sapiens	73-77
33429571-1	2017	Fibroblast growth factor 2 (FGF-2), an important paracrine growth factor, binds electrostatically with low micromolar affinity to heparan sulfates present on extracellular matrix proteins.	Heparitin Sulfate	130-146	fibroblast growth factor 2	Homo sapiens	0-26
33429571-1	2017	Fibroblast growth factor 2 (FGF-2), an important paracrine growth factor, binds electrostatically with low micromolar affinity to heparan sulfates present on extracellular matrix proteins.	Heparitin Sulfate	130-146	fibroblast growth factor 2	Homo sapiens	28-33
33429571-2	2017	A single molecular analysis served as a basis to decipher the nanomechanical mechanism of the interaction between FGF-2 and the heparan sulfate surrogate, heparin, with a modular atomic force microscope (AFM) design combining magnetic actuators with force measurements at the low force regime (1 x 101 to 1 x 104 pN/s).	Heparitin Sulfate	128-143	fibroblast growth factor 2	Homo sapiens	114-119
28659919-7	2017	Postoperative heparanase levels positively correlated with noradrenalin dose at 12 h after ICU admission and showed a high predictive value of vasopressor requirements within the first 24 h. Postoperative heparan sulfate showed a strong positive correlation with interleukin-6 levels day 0, 1, and 2 post-ICU admission and a strong negative correlation with lactate clearance during the first 6 h post-ICU admission.	Heparitin Sulfate	205-220	interleukin 6	Mus musculus	263-276
28664165-1	2017	Sanfilippo syndrome type B (mucopolysaccharidosis IIIB), caused by inherited deficiency of alpha-N-acetylglucosaminidase (NAGLU), required for lysosomal degradation of heparan sulfate (HS), is a pediatric neurodegenerative disorder with no approved treatment.	Heparitin Sulfate	168-183	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	91-120
28664165-1	2017	Sanfilippo syndrome type B (mucopolysaccharidosis IIIB), caused by inherited deficiency of alpha-N-acetylglucosaminidase (NAGLU), required for lysosomal degradation of heparan sulfate (HS), is a pediatric neurodegenerative disorder with no approved treatment.	Heparitin Sulfate	168-183	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	122-127
28593992-1	2017	Hunter syndrome is a rare but devastating childhood disease caused by mutations in the IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate.	Heparitin Sulfate	206-221	iduronate 2-sulfatase	Homo sapiens	87-90
28593992-1	2017	Hunter syndrome is a rare but devastating childhood disease caused by mutations in the IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate.	Heparitin Sulfate	206-221	iduronate 2-sulfatase	Homo sapiens	105-126
28664165-1	2017	Sanfilippo syndrome type B (mucopolysaccharidosis IIIB), caused by inherited deficiency of alpha-N-acetylglucosaminidase (NAGLU), required for lysosomal degradation of heparan sulfate (HS), is a pediatric neurodegenerative disorder with no approved treatment.	Heparitin Sulfate	185-187	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	91-120
28664165-1	2017	Sanfilippo syndrome type B (mucopolysaccharidosis IIIB), caused by inherited deficiency of alpha-N-acetylglucosaminidase (NAGLU), required for lysosomal degradation of heparan sulfate (HS), is a pediatric neurodegenerative disorder with no approved treatment.	Heparitin Sulfate	185-187	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	122-127
27744520-4	2017	In this study, we employed a siRNA knockdown approach for heparan sulphate (EXT1) and heparan/chondroitin/dermatan sulphate-biosynthetic enzymes (beta4GalT7) in the aggressive human breast cancer cell line MDA-MB-231 to study the impact on cell behaviour and hyaluronan biosynthesis.	Heparitin Sulfate	58-74	exostosin glycosyltransferase 1	Homo sapiens	76-80
28466453-4	2017	RECENT FINDINGS: Most HME cases are linked to loss-of-function mutations in EXT1 or EXT2 that encode glycosyltransferases responsible for heparan sulfate (HS) synthesis, leading to HS deficiency.	Heparitin Sulfate	138-153	exostosin glycosyltransferase 1	Homo sapiens	76-80
28466453-4	2017	RECENT FINDINGS: Most HME cases are linked to loss-of-function mutations in EXT1 or EXT2 that encode glycosyltransferases responsible for heparan sulfate (HS) synthesis, leading to HS deficiency.	Heparitin Sulfate	138-153	exostosin glycosyltransferase 2	Homo sapiens	84-88
28466453-4	2017	RECENT FINDINGS: Most HME cases are linked to loss-of-function mutations in EXT1 or EXT2 that encode glycosyltransferases responsible for heparan sulfate (HS) synthesis, leading to HS deficiency.	Heparitin Sulfate	155-157	exostosin glycosyltransferase 1	Homo sapiens	76-80
28466453-4	2017	RECENT FINDINGS: Most HME cases are linked to loss-of-function mutations in EXT1 or EXT2 that encode glycosyltransferases responsible for heparan sulfate (HS) synthesis, leading to HS deficiency.	Heparitin Sulfate	155-157	exostosin glycosyltransferase 2	Homo sapiens	84-88
28025251-3	2017	Heparanase (HPSE) is an endoglycosidase that cleaves HS in the ECM and cell membrane.	Heparitin Sulfate	53-55	heparanase	Homo sapiens	0-10
28025251-3	2017	Heparanase (HPSE) is an endoglycosidase that cleaves HS in the ECM and cell membrane.	Heparitin Sulfate	53-55	heparanase	Homo sapiens	12-16
28025251-4	2017	By degrading HS, HPSE not only alters the integrity of the ECM but also releases growth factors and angiogenic factors bound to HS chains, therefore, changes various cellular activities, including cell mobility that is critical for cancer metastasis.	Heparitin Sulfate	13-15	heparanase	Homo sapiens	17-21
28025251-6	2017	Here, we describe a method for non-reducing end labeling of HS via click chemistry (CC), and further use it in a novel HPSE assay.	Heparitin Sulfate	60-62	heparanase	Homo sapiens	119-123
28187268-6	2017	Homeostatic pulmonary endothelial glycocalyx reconstitution occurred rapidly after nonseptic degradation and was associated with induction of the HS biosynthetic enzyme, exostosin (EXT)-1.	Heparitin Sulfate	146-148	exostosin-like glycosyltransferase 3	Mus musculus	170-179
28187268-6	2017	Homeostatic pulmonary endothelial glycocalyx reconstitution occurred rapidly after nonseptic degradation and was associated with induction of the HS biosynthetic enzyme, exostosin (EXT)-1.	Heparitin Sulfate	146-148	exostosin glycosyltransferase 1	Mus musculus	181-187
28588666-1	2017	Hunter syndrome (or mucopolysaccharidosis type II, MPS II) is an X-linked recessive disorder induced by a deficiency of the iduronate 2-sulfatase (IDS) enzyme, resulting in the accumulation of glycosaminoglycan substrates, heparan sulfate and dermatan sulfate, in the lysosomes.	Heparitin Sulfate	223-238	iduronate 2-sulfatase	Homo sapiens	124-145
28588666-1	2017	Hunter syndrome (or mucopolysaccharidosis type II, MPS II) is an X-linked recessive disorder induced by a deficiency of the iduronate 2-sulfatase (IDS) enzyme, resulting in the accumulation of glycosaminoglycan substrates, heparan sulfate and dermatan sulfate, in the lysosomes.	Heparitin Sulfate	223-238	iduronate 2-sulfatase	Homo sapiens	147-150
28539925-6	2017	Compared to CXCL9(74-103), CXCL9(74-93) showed equally high affinity for heparin and heparan sulfate (HS), but lower affinity for binding to chondroitin sulfate (CS) and cellular GAGs.	Heparitin Sulfate	85-100	chemokine (C-X-C motif) ligand 9	Mus musculus	27-32
28381397-4	2017	Surface expression of CD138 increased heparan sulfate levels on ASCs, which are known to bind pro-survival cytokines, leading to increased survival in a cell-intrinsic manner in vivo.	Heparitin Sulfate	38-53	syndecan 1	Homo sapiens	22-27
28558026-4	2017	Using this system, we demonstrate that heparin, an analog of heparan sulfate, induced the dimerization of RPTPsigma, whereas chondroitin sulfate increased RPTPsigma activity by inhibiting RPTPsigma dimerization.	Heparitin Sulfate	61-76	protein tyrosine phosphatase receptor type S	Homo sapiens	106-115
28539925-6	2017	Compared to CXCL9(74-103), CXCL9(74-93) showed equally high affinity for heparin and heparan sulfate (HS), but lower affinity for binding to chondroitin sulfate (CS) and cellular GAGs.	Heparitin Sulfate	102-104	chemokine (C-X-C motif) ligand 9	Mus musculus	27-32
28300561-0	2017	Nucleolin is a nuclear target of heparan sulfate derived from glypican-1.	Heparitin Sulfate	33-48	nucleolin	Mus musculus	0-9
28264929-0	2017	The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.	Heparitin Sulfate	33-48	agouti related neuropeptide	Homo sapiens	4-26
28264929-2	2017	Through heparan sulfate moieties, syndecans are thought to anchor AgRP near its receptor, enhancing its orexigenic effects.	Heparitin Sulfate	8-23	agouti related neuropeptide	Homo sapiens	66-70
28264929-5	2017	Addressing this long-standing incongruity, we used calorimetry and magnetic resonance to probe interactions of AgRP peptides with glycosaminoglycans, including heparan sulfate.	Heparitin Sulfate	160-175	agouti related neuropeptide	Homo sapiens	111-115
28264929-6	2017	We show that mature, cleaved, C-terminal AgRP, not the N-terminal domain, binds heparan sulfate.	Heparitin Sulfate	80-95	agouti related neuropeptide	Homo sapiens	41-45
28401457-1	2017	IDS is responsible for the lysosomal degradation of heparan sulfate and dermatan sulfate and linked to an X-linked lysosomal storage disease, mucopolysaccharidosis 2 (MPS2), resulting in neurological damage and early death.	Heparitin Sulfate	52-67	iduronate 2-sulfatase	Homo sapiens	0-3
28249356-6	2017	Mislocalization of ss1-integrin, reductions in fibronectin, and alterations in heparan sulfate content all contribute to reduced FGF responsiveness in satellite cells.	Heparitin Sulfate	79-94	fibroblast growth factor 2	Homo sapiens	129-132
28300561-0	2017	Nucleolin is a nuclear target of heparan sulfate derived from glypican-1.	Heparitin Sulfate	33-48	glypican 1	Mus musculus	62-72
28300561-1	2017	The recycling, S-nitrosylated heparan sulfate (HS) proteoglycan glypican-1 releases anhydromannose (anMan)-containing HS chains by a nitrosothiol-catalyzed cleavage in endosomes that can be constitutive or induced by ascorbate.	Heparitin Sulfate	30-45	glypican 1	Mus musculus	64-74
28300561-1	2017	The recycling, S-nitrosylated heparan sulfate (HS) proteoglycan glypican-1 releases anhydromannose (anMan)-containing HS chains by a nitrosothiol-catalyzed cleavage in endosomes that can be constitutive or induced by ascorbate.	Heparitin Sulfate	47-49	glypican 1	Mus musculus	64-74
28300561-1	2017	The recycling, S-nitrosylated heparan sulfate (HS) proteoglycan glypican-1 releases anhydromannose (anMan)-containing HS chains by a nitrosothiol-catalyzed cleavage in endosomes that can be constitutive or induced by ascorbate.	Heparitin Sulfate	118-120	glypican 1	Mus musculus	64-74
27585241-5	2017	Biglycan was found to form a complex with either transforming growth factor-beta1 or the transforming growth factor-beta1 type I receptor, ALK5, and to intensify the phosphorylation of Smad2/3, resulting in a lower expression of the transmembrane heparan sulfate proteoglycan, syndecan-4.	Heparitin Sulfate	247-262	biglycan	Bos taurus	0-8
28174207-7	2017	Heparan sulfate proteoglycans and heparin derivatives further enhance HBEGF-induced differentiation by forming a complex with the epidermal growth factor receptor, leading to activation of the ERK1/2 and STAT3 pathways and up-regulation of the inhibitor of DNA binding transcription factor.	Heparitin Sulfate	0-15	heparin binding EGF like growth factor	Homo sapiens	70-75
28174207-7	2017	Heparan sulfate proteoglycans and heparin derivatives further enhance HBEGF-induced differentiation by forming a complex with the epidermal growth factor receptor, leading to activation of the ERK1/2 and STAT3 pathways and up-regulation of the inhibitor of DNA binding transcription factor.	Heparitin Sulfate	0-15	epidermal growth factor receptor	Homo sapiens	130-162
28174207-7	2017	Heparan sulfate proteoglycans and heparin derivatives further enhance HBEGF-induced differentiation by forming a complex with the epidermal growth factor receptor, leading to activation of the ERK1/2 and STAT3 pathways and up-regulation of the inhibitor of DNA binding transcription factor.	Heparitin Sulfate	0-15	mitogen-activated protein kinase 3	Homo sapiens	193-199
28174207-7	2017	Heparan sulfate proteoglycans and heparin derivatives further enhance HBEGF-induced differentiation by forming a complex with the epidermal growth factor receptor, leading to activation of the ERK1/2 and STAT3 pathways and up-regulation of the inhibitor of DNA binding transcription factor.	Heparitin Sulfate	0-15	signal transducer and activator of transcription 3	Homo sapiens	204-209
27585241-5	2017	Biglycan was found to form a complex with either transforming growth factor-beta1 or the transforming growth factor-beta1 type I receptor, ALK5, and to intensify the phosphorylation of Smad2/3, resulting in a lower expression of the transmembrane heparan sulfate proteoglycan, syndecan-4.	Heparitin Sulfate	247-262	SMAD family member 2	Bos taurus	185-192
28120511-10	2017	We also demonstrated that heparin sulfate modification significantly improved bFGF immobilization and absorption to the collagen by examining the release kinetics of bFGF from scaffolds.	Heparitin Sulfate	26-41	fibroblast growth factor 2	Rattus norvegicus	78-82
28120511-10	2017	We also demonstrated that heparin sulfate modification significantly improved bFGF immobilization and absorption to the collagen by examining the release kinetics of bFGF from scaffolds.	Heparitin Sulfate	26-41	fibroblast growth factor 2	Rattus norvegicus	166-170
28445472-1	2017	Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2.	Heparitin Sulfate	128-143	exostosin glycosyltransferase 1	Homo sapiens	170-174
28180900-5	2017	Substitution of selected amino acid residues in DKK2 designed to decrease heparan sulfate binding by HSA-DKK2 variants, further improved the PK properties of the molecule in rodents.	Heparitin Sulfate	74-89	dickkopf WNT signaling pathway inhibitor 2	Homo sapiens	48-52
28180900-5	2017	Substitution of selected amino acid residues in DKK2 designed to decrease heparan sulfate binding by HSA-DKK2 variants, further improved the PK properties of the molecule in rodents.	Heparitin Sulfate	74-89	dickkopf WNT signaling pathway inhibitor 2	Homo sapiens	105-109
27496348-0	2017	Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling.	Heparitin Sulfate	19-34	fibroblast growth factor 2	Homo sapiens	108-112
28468283-1	2017	Of the circa 40 cytokines of the TGF-beta superfamily, around a third are currently known to bind to heparin and heparan sulphate.	Heparitin Sulfate	113-129	transforming growth factor beta 1	Homo sapiens	33-41
28445472-1	2017	Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2.	Heparitin Sulfate	128-143	exostosin glycosyltransferase 2	Homo sapiens	178-182
28445472-1	2017	Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2.	Heparitin Sulfate	145-147	exostosin glycosyltransferase 1	Homo sapiens	170-174
28445472-1	2017	Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2.	Heparitin Sulfate	145-147	exostosin glycosyltransferase 2	Homo sapiens	178-182
28438208-9	2017	The protective mechanism of DcR3 mediates through interacting with heparan sulfate proteoglycans and activating IL-4+YM1+ M2a-like microglia that reduces Abeta-induced proinflammatory cytokines and promotes phagocytosis ability of microglia.	Heparitin Sulfate	67-82	Dcr3	Mus musculus	28-32
28439042-0	2017	Correction: Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif.	Heparitin Sulfate	61-76	gremlin 2, DAN family BMP antagonist	Homo sapiens	47-52
28938567-3	2017	In this study, we demonstrated that gemcitabine increased the expression of heparanase (HPA1), the only known mammalian endoglycosidase capable of cleaving heparan sulfate, both in vitro and in vivo.	Heparitin Sulfate	156-171	heparanase	Homo sapiens	76-86
28397746-6	2017	Moreover, the alteration of endogenous heparan sulfates has been found to cause a reduction in hepcidin expression in vitro and in vivo, indicating that heparins act by interfering with the interaction between BMPs and components of the complex involved in the activation of the BMP/SMAD1/5/8 pathway.	Heparitin Sulfate	39-55	hepcidin antimicrobial peptide	Mus musculus	95-103
28397746-6	2017	Moreover, the alteration of endogenous heparan sulfates has been found to cause a reduction in hepcidin expression in vitro and in vivo, indicating that heparins act by interfering with the interaction between BMPs and components of the complex involved in the activation of the BMP/SMAD1/5/8 pathway.	Heparitin Sulfate	39-55	SMAD family member 1	Mus musculus	283-290
28938567-3	2017	In this study, we demonstrated that gemcitabine increased the expression of heparanase (HPA1), the only known mammalian endoglycosidase capable of cleaving heparan sulfate, both in vitro and in vivo.	Heparitin Sulfate	156-171	heparanase	Homo sapiens	88-92
28978009-4	2017	Here, we find that cancer cell internalization of CAIX is negatively regulated by post-translational modification with chondroitin or heparan sulfate glycosaminoglycan chains.	Heparitin Sulfate	134-149	carbonic anhydrase 9	Homo sapiens	50-54
32646162-0	2017	Enhanced Biological Activity of BMP-2 Bound to Surface-Grafted Heparan Sulfate.	Heparitin Sulfate	63-78	bone morphogenetic protein 2	Mus musculus	32-37
32646162-2	2017	This study reports the development and application of model surfaces that present BMP-2 via heparan sulfate (HS), a ubiquitous component of the extracellular matrix (ECM).	Heparitin Sulfate	92-107	bone morphogenetic protein 2	Mus musculus	82-87
32646162-2	2017	This study reports the development and application of model surfaces that present BMP-2 via heparan sulfate (HS), a ubiquitous component of the extracellular matrix (ECM).	Heparitin Sulfate	109-111	bone morphogenetic protein 2	Mus musculus	82-87
27899064-2	2017	Growth differentiation factor 5 (GDF5) belongs to the bone morphogenetic protein family of proteins and is vital for skeletal formation; however, its interaction with heparin and heparan sulfate (HS) has not been studied.	Heparitin Sulfate	179-194	growth differentiation factor 5	Homo sapiens	0-31
28209511-0	2017	Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway.	Heparitin Sulfate	33-48	heparanase	Homo sapiens	0-12
28209511-0	2017	Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway.	Heparitin Sulfate	33-48	syndecan 1	Homo sapiens	54-64
28209511-0	2017	Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway.	Heparitin Sulfate	33-48	vascular endothelial growth factor C	Homo sapiens	146-152
28209511-0	2017	Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway.	Heparitin Sulfate	33-48	mitogen-activated protein kinase 1	Homo sapiens	153-156
28209511-2	2017	The main mechanism includes heparanase-1 (HPA-1) degrades the heparan sulfate chain of syndecan-1 (SDC-1), and the following shedding of heparan sulfate from tumor cell releases and activates SDC-1 sequestered growth factors.	Heparitin Sulfate	62-77	heparanase	Homo sapiens	28-40
28209511-2	2017	The main mechanism includes heparanase-1 (HPA-1) degrades the heparan sulfate chain of syndecan-1 (SDC-1), and the following shedding of heparan sulfate from tumor cell releases and activates SDC-1 sequestered growth factors.	Heparitin Sulfate	62-77	heparanase	Homo sapiens	42-47
28209511-2	2017	The main mechanism includes heparanase-1 (HPA-1) degrades the heparan sulfate chain of syndecan-1 (SDC-1), and the following shedding of heparan sulfate from tumor cell releases and activates SDC-1 sequestered growth factors.	Heparitin Sulfate	62-77	syndecan 1	Homo sapiens	87-97
28209511-2	2017	The main mechanism includes heparanase-1 (HPA-1) degrades the heparan sulfate chain of syndecan-1 (SDC-1), and the following shedding of heparan sulfate from tumor cell releases and activates SDC-1 sequestered growth factors.	Heparitin Sulfate	137-152	heparanase	Homo sapiens	28-40
28209511-2	2017	The main mechanism includes heparanase-1 (HPA-1) degrades the heparan sulfate chain of syndecan-1 (SDC-1), and the following shedding of heparan sulfate from tumor cell releases and activates SDC-1 sequestered growth factors.	Heparitin Sulfate	137-152	heparanase	Homo sapiens	42-47
28209511-2	2017	The main mechanism includes heparanase-1 (HPA-1) degrades the heparan sulfate chain of syndecan-1 (SDC-1), and the following shedding of heparan sulfate from tumor cell releases and activates SDC-1 sequestered growth factors.	Heparitin Sulfate	137-152	syndecan 1	Homo sapiens	87-97
28209511-2	2017	The main mechanism includes heparanase-1 (HPA-1) degrades the heparan sulfate chain of syndecan-1 (SDC-1), and the following shedding of heparan sulfate from tumor cell releases and activates SDC-1 sequestered growth factors.	Heparitin Sulfate	137-152	syndecan 1	Homo sapiens	99-104
28209511-2	2017	The main mechanism includes heparanase-1 (HPA-1) degrades the heparan sulfate chain of syndecan-1 (SDC-1), and the following shedding of heparan sulfate from tumor cell releases and activates SDC-1 sequestered growth factors.	Heparitin Sulfate	137-152	syndecan 1	Homo sapiens	192-197
28209511-4	2017	Herein, we found that HPA-1 could degrade the heparan sulfate on hepatocarcinoma cell surface.	Heparitin Sulfate	46-61	heparanase	Homo sapiens	22-27
28209511-5	2017	Importantly, HPA-1-induced shedding of heparan sulfate chain from SDC-1 facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1/VEGF-C complex into the medium of hepatocarcinoma cell.	Heparitin Sulfate	39-54	heparanase	Homo sapiens	13-18
28209511-5	2017	Importantly, HPA-1-induced shedding of heparan sulfate chain from SDC-1 facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1/VEGF-C complex into the medium of hepatocarcinoma cell.	Heparitin Sulfate	39-54	syndecan 1	Homo sapiens	66-71
28209511-5	2017	Importantly, HPA-1-induced shedding of heparan sulfate chain from SDC-1 facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1/VEGF-C complex into the medium of hepatocarcinoma cell.	Heparitin Sulfate	39-54	vascular endothelial growth factor C	Homo sapiens	99-135
28209511-5	2017	Importantly, HPA-1-induced shedding of heparan sulfate chain from SDC-1 facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1/VEGF-C complex into the medium of hepatocarcinoma cell.	Heparitin Sulfate	39-54	vascular endothelial growth factor C	Homo sapiens	137-143
28209511-5	2017	Importantly, HPA-1-induced shedding of heparan sulfate chain from SDC-1 facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1/VEGF-C complex into the medium of hepatocarcinoma cell.	Heparitin Sulfate	39-54	syndecan 1	Homo sapiens	150-155
28209511-5	2017	Importantly, HPA-1-induced shedding of heparan sulfate chain from SDC-1 facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1/VEGF-C complex into the medium of hepatocarcinoma cell.	Heparitin Sulfate	39-54	vascular endothelial growth factor C	Homo sapiens	156-162
28170292-1	2017	Heparanase, a heparan sulfate (HS)-specific endoglycosidase, plays an important role in inflammation and mediates acute pulmonary and renal injuries during sepsis.	Heparitin Sulfate	14-29	heparanase	Mus musculus	0-10
28170292-1	2017	Heparanase, a heparan sulfate (HS)-specific endoglycosidase, plays an important role in inflammation and mediates acute pulmonary and renal injuries during sepsis.	Heparitin Sulfate	31-33	heparanase	Mus musculus	0-10
28152381-0	2017	Binding of the chemokine CXCL12alpha to its natural extracellular matrix ligand heparan sulfate enables myoblast adhesion and facilitates cell motility.	Heparitin Sulfate	80-95	C-X-C motif chemokine ligand 12	Homo sapiens	25-31
28031321-2	2017	Here, we report that the dextran sulfate sodium (DSS)-induced mouse model of chronic colitis is associated with increases in the serum level of IL-1beta and the colonic epithelial expression of the cell-surface heparan sulfate proteoglycan, syndecan-2.	Heparitin Sulfate	211-226	syndecan 2	Mus musculus	241-251
28205415-0	2017	Microfluidic Screening Reveals Heparan Sulfate Enhances Human Mesenchymal Stem Cell Growth by Modulating Fibroblast Growth Factor-2 Transport.	Heparitin Sulfate	31-46	fibroblast growth factor 2	Homo sapiens	105-131
28205415-3	2017	However, hMSCs also produce endogenous FGF-2, which critically interacts with cell surface heparan sulfate (HS).	Heparitin Sulfate	91-106	fibroblast growth factor 2	Homo sapiens	39-44
28205415-3	2017	However, hMSCs also produce endogenous FGF-2, which critically interacts with cell surface heparan sulfate (HS).	Heparitin Sulfate	108-110	fibroblast growth factor 2	Homo sapiens	39-44
28205415-4	2017	We assessed the interplay of FGF-2 with a heparan sulfate variant (HS8) engineered to bind FGF-2 and potentiate its activity.	Heparitin Sulfate	42-57	fibroblast growth factor 2	Homo sapiens	91-96
27899064-2	2017	Growth differentiation factor 5 (GDF5) belongs to the bone morphogenetic protein family of proteins and is vital for skeletal formation; however, its interaction with heparin and heparan sulfate (HS) has not been studied.	Heparitin Sulfate	179-194	growth differentiation factor 5	Homo sapiens	33-37
27899064-2	2017	Growth differentiation factor 5 (GDF5) belongs to the bone morphogenetic protein family of proteins and is vital for skeletal formation; however, its interaction with heparin and heparan sulfate (HS) has not been studied.	Heparitin Sulfate	196-198	growth differentiation factor 5	Homo sapiens	0-31
27899064-2	2017	Growth differentiation factor 5 (GDF5) belongs to the bone morphogenetic protein family of proteins and is vital for skeletal formation; however, its interaction with heparin and heparan sulfate (HS) has not been studied.	Heparitin Sulfate	196-198	growth differentiation factor 5	Homo sapiens	33-37
28196860-6	2017	Our data also implicate NCX-9 in a LON-2/heparan sulfate and UNC-6/netrin-mediated, RAC-dependent signaling pathway to guide left/right patterning within this circuit.	Heparitin Sulfate	41-56	Mitochondrial sodium/calcium exchanger protein	Caenorhabditis elegans	24-29
28196860-6	2017	Our data also implicate NCX-9 in a LON-2/heparan sulfate and UNC-6/netrin-mediated, RAC-dependent signaling pathway to guide left/right patterning within this circuit.	Heparitin Sulfate	41-56	LONg	Caenorhabditis elegans	35-40
28290520-9	2017	This could potentially be attributed to reduced glycosaminoglycan binding ability, as surface plasmon resonance spectroscopy showed that nitration reduced heparan sulphate binding by CCL2.	Heparitin Sulfate	155-171	chemokine (C-C motif) ligand 2	Mus musculus	183-187
28292981-15	2017	Results revealed that heparan sulfate present in the vagina of mice susceptible to chronic vaginitis served as a competitive ligand for the receptor (Mac-1) necessary for fungal recognition and neutrophil-mediated killing.	Heparitin Sulfate	22-37	integrin alpha M	Mus musculus	150-155
28104757-0	2017	Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif.	Heparitin Sulfate	49-64	gremlin 2, DAN family BMP antagonist	Homo sapiens	35-40
28104757-2	2017	Similar to the BMP ligands, certain DAN family members have been shown to interact with heparin and heparan sulfate (HS).	Heparitin Sulfate	100-115	bone morphogenetic protein 1	Homo sapiens	15-18
28104757-2	2017	Similar to the BMP ligands, certain DAN family members have been shown to interact with heparin and heparan sulfate (HS).	Heparitin Sulfate	100-115	NBL1, DAN family BMP antagonist	Homo sapiens	36-39
28104757-2	2017	Similar to the BMP ligands, certain DAN family members have been shown to interact with heparin and heparan sulfate (HS).	Heparitin Sulfate	117-119	bone morphogenetic protein 1	Homo sapiens	15-18
28104757-2	2017	Similar to the BMP ligands, certain DAN family members have been shown to interact with heparin and heparan sulfate (HS).	Heparitin Sulfate	117-119	NBL1, DAN family BMP antagonist	Homo sapiens	36-39
28104757-4	2017	In the present study, we used mutagenesis, heparin-binding measurements, and cell surface-binding analysis to identify lysine residues that are important for heparin/HS binding in Grem2.	Heparitin Sulfate	166-168	gremlin 2, DAN family BMP antagonist	Homo sapiens	180-185
28104757-5	2017	We determined that residues involved in heparin/HS binding, while not necessary for BMP antagonism, merge with the heparin/HS-binding epitope of BMP2.	Heparitin Sulfate	48-50	bone morphogenetic protein 2	Homo sapiens	145-149
28270211-3	2017	The heparan sulfate proteoglycan Syndecan-1 acts as a coreceptor for growth factors and chemokines, modulating inflammation, tumor progression, and cancer stemness, thus it may emerge as a molecular marker for IBC.	Heparitin Sulfate	4-19	syndecan 1	Homo sapiens	33-43
27291835-0	2017	Affinity Selection of FGF2-Binding Heparan Sulfates for Ex Vivo Expansion of Human Mesenchymal Stem Cells.	Heparitin Sulfate	35-51	fibroblast growth factor 2	Homo sapiens	22-26
28148688-2	2017	Whole-exome sequencing revealed homozygous missense mutations affecting exostosin-like 3 (EXTL3), a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	132-147	exostosin like glycosyltransferase 3	Homo sapiens	72-88
28148688-2	2017	Whole-exome sequencing revealed homozygous missense mutations affecting exostosin-like 3 (EXTL3), a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	132-147	exostosin like glycosyltransferase 3	Homo sapiens	90-95
28148688-2	2017	Whole-exome sequencing revealed homozygous missense mutations affecting exostosin-like 3 (EXTL3), a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	149-151	exostosin like glycosyltransferase 3	Homo sapiens	72-88
28148688-2	2017	Whole-exome sequencing revealed homozygous missense mutations affecting exostosin-like 3 (EXTL3), a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	149-151	exostosin like glycosyltransferase 3	Homo sapiens	90-95
28211985-1	2017	NDST1 encodes an enzyme involved in the first steps in the synthesis of heparan sulfate chains, proteoglycans that are regulators found on the cell surface and in the extracellular matrix.	Heparitin Sulfate	72-87	N-deacetylase and N-sulfotransferase 1	Homo sapiens	0-5
27291835-3	2017	The biological activity of FGF2 is controlled through interactions with heparan sulfate (HS) that facilitates ligand-receptor complex formation.	Heparitin Sulfate	72-87	fibroblast growth factor 2	Homo sapiens	27-31
27291835-3	2017	The biological activity of FGF2 is controlled through interactions with heparan sulfate (HS) that facilitates ligand-receptor complex formation.	Heparitin Sulfate	89-91	fibroblast growth factor 2	Homo sapiens	27-31
28031461-0	2017	Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c.	Heparitin Sulfate	0-15	fibroblast growth factor 1	Homo sapiens	37-69
28286736-1	2017	Heparan sulfate (HS) mediates the activity of various growth factors including TGF-beta.	Heparitin Sulfate	0-15	transforming growth factor beta 1	Homo sapiens	79-87
28286736-1	2017	Heparan sulfate (HS) mediates the activity of various growth factors including TGF-beta.	Heparitin Sulfate	17-19	transforming growth factor beta 1	Homo sapiens	79-87
28286736-2	2017	Heparanase is an endo-glucuronidase that specifically cleaves and modifies HS structure.	Heparitin Sulfate	75-77	heparanase	Homo sapiens	0-10
28207863-1	2017	Severe mucopolysaccharidosis type II (MPS II) is a progressive lysosomal storage disease caused by mutations in the IDS gene, leading to a deficiency in the iduronate-2-sulfatase enzyme that is involved in heparan sulphate and dermatan sulphate catabolism.	Heparitin Sulfate	206-222	iduronate 2-sulfatase	Mus musculus	116-119
28207863-1	2017	Severe mucopolysaccharidosis type II (MPS II) is a progressive lysosomal storage disease caused by mutations in the IDS gene, leading to a deficiency in the iduronate-2-sulfatase enzyme that is involved in heparan sulphate and dermatan sulphate catabolism.	Heparitin Sulfate	206-222	iduronate 2-sulfatase	Mus musculus	157-178
28031461-4	2017	The results suggest that FGF12-FGFR1c2 binding site prefers a longer NS domain at the non-reducing terminus than FGF22-FGFR1c2 In addition, FGF22-FGFR1c2 can tolerate an HS chain having an N-acetylglucosamine residue at its non-reducing end.	Heparitin Sulfate	170-172	fibroblast growth factor 12	Homo sapiens	25-30
28031461-4	2017	The results suggest that FGF12-FGFR1c2 binding site prefers a longer NS domain at the non-reducing terminus than FGF22-FGFR1c2 In addition, FGF22-FGFR1c2 can tolerate an HS chain having an N-acetylglucosamine residue at its non-reducing end.	Heparitin Sulfate	170-172	fibroblast growth factor 22	Homo sapiens	113-118
28031461-4	2017	The results suggest that FGF12-FGFR1c2 binding site prefers a longer NS domain at the non-reducing terminus than FGF22-FGFR1c2 In addition, FGF22-FGFR1c2 can tolerate an HS chain having an N-acetylglucosamine residue at its non-reducing end.	Heparitin Sulfate	170-172	fibroblast growth factor 22	Homo sapiens	140-145
28031461-5	2017	These results clearly demonstrate the different specificity of FGF12-FGFR1c2 and FGF22-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling.	Heparitin Sulfate	112-114	fibroblast growth factor 12	Homo sapiens	63-68
28031461-5	2017	These results clearly demonstrate the different specificity of FGF12-FGFR1c2 and FGF22-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling.	Heparitin Sulfate	112-114	fibroblast growth factor 22	Homo sapiens	81-86
28132690-1	2017	EXTL3 regulates the biosynthesis of heparan sulfate (HS), important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs).	Heparitin Sulfate	36-51	exostosin like glycosyltransferase 3	Homo sapiens	0-5
28132690-1	2017	EXTL3 regulates the biosynthesis of heparan sulfate (HS), important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs).	Heparitin Sulfate	53-55	exostosin like glycosyltransferase 3	Homo sapiens	0-5
27585464-1	2017	Mucopolysaccharidosis type IIIA (MPS IIIA, Sanfilippo A) is a neurodegenerative lysosomal storage disorder caused by the deficiency of sulphamidase enzyme (SGSH) leading to accumulation of heparan sulfate (HS).	Heparitin Sulfate	189-204	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	135-147
27585464-1	2017	Mucopolysaccharidosis type IIIA (MPS IIIA, Sanfilippo A) is a neurodegenerative lysosomal storage disorder caused by the deficiency of sulphamidase enzyme (SGSH) leading to accumulation of heparan sulfate (HS).	Heparitin Sulfate	189-204	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	156-160
27585464-1	2017	Mucopolysaccharidosis type IIIA (MPS IIIA, Sanfilippo A) is a neurodegenerative lysosomal storage disorder caused by the deficiency of sulphamidase enzyme (SGSH) leading to accumulation of heparan sulfate (HS).	Heparitin Sulfate	206-208	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	135-147
27585464-1	2017	Mucopolysaccharidosis type IIIA (MPS IIIA, Sanfilippo A) is a neurodegenerative lysosomal storage disorder caused by the deficiency of sulphamidase enzyme (SGSH) leading to accumulation of heparan sulfate (HS).	Heparitin Sulfate	206-208	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	156-160
27693511-10	2017	We found levels of mRNAs encoding heparan sulfate proteoglycans (HSPGs), particularly SDC1 mRNA, and cell surface levels of heparan sulfate to be reduced in cells after SMAD6 knockdown.	Heparitin Sulfate	34-49	SMAD family member 6	Homo sapiens	169-174
28082743-9	2017	The uptake of ASC-derived artificial nanovesicles was inhibited by heparin, which is a competitive inhibitor of heparan sulfate proteoglycan that is associated with FGF2 signaling.	Heparitin Sulfate	112-127	fibroblast growth factor 2	Mus musculus	165-169
28451171-3	2017	Masking of extracellular (ECM)-resident heparan sulfate (HS) through metalloshielding results in very effective inhibition of physiologically critical HS functions including enzyme (heparanase, HPSE) and protein growth factor recognition.	Heparitin Sulfate	40-55	heparanase	Homo sapiens	194-198
28451171-3	2017	Masking of extracellular (ECM)-resident heparan sulfate (HS) through metalloshielding results in very effective inhibition of physiologically critical HS functions including enzyme (heparanase, HPSE) and protein growth factor recognition.	Heparitin Sulfate	57-59	heparanase	Homo sapiens	194-198
27758044-2	2017	Heparanase accomplishes this by degrading heparan sulfate which regulates the abundance and location of heparin-binding growth factors thereby influencing multiple signaling pathways that control gene expression, syndecan shedding and cell behavior.	Heparitin Sulfate	42-57	heparanase	Homo sapiens	0-10
27758044-2	2017	Heparanase accomplishes this by degrading heparan sulfate which regulates the abundance and location of heparin-binding growth factors thereby influencing multiple signaling pathways that control gene expression, syndecan shedding and cell behavior.	Heparitin Sulfate	42-57	syndecan 1	Homo sapiens	213-221
27535874-4	2017	We previously demonstrated that OECs express higher levels of sulfatases, enzymes that remove 6-O-sulfate groups from heparan sulphate proteoglycans, than SCs and that RNAi knockdown of sulfatase prevented OEC-astrocyte mixing in vitro.	Heparitin Sulfate	118-134	arylsulfatase family member H	Homo sapiens	62-71
27543953-4	2016	In this study, highly metastatic renal cell carcinoma cells were genetically modified to suppress HS production by knocking down its synthetic enzyme NDST1.	Heparitin Sulfate	98-100	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	150-155
28013294-9	2017	Lysosomal over-acidification and HS accumulation were detected in patient-derived and VPS33A-depleted cells, suggesting a novel role of this gene in lysosomal functions.	Heparitin Sulfate	33-35	VPS33A core subunit of CORVET and HOPS complexes	Homo sapiens	86-92
28387673-1	2017	BACKGROUND: Heparan sulfate proteoglycans (HSPGs) promote amyloid-beta peptide and tau fibrillization in Alzheimer"s disease (AD) and provide resistance against proteolytic breakdown.	Heparitin Sulfate	12-27	microtubule associated protein tau	Homo sapiens	83-86
28387673-2	2017	Heparanase (HPSE) is the only enzyme that cleaves heparan sulfate (HS).	Heparitin Sulfate	50-65	heparanase	Homo sapiens	0-10
28387673-2	2017	Heparanase (HPSE) is the only enzyme that cleaves heparan sulfate (HS).	Heparitin Sulfate	50-65	heparanase	Homo sapiens	12-16
28387673-2	2017	Heparanase (HPSE) is the only enzyme that cleaves heparan sulfate (HS).	Heparitin Sulfate	67-69	heparanase	Homo sapiens	0-10
28387673-2	2017	Heparanase (HPSE) is the only enzyme that cleaves heparan sulfate (HS).	Heparitin Sulfate	67-69	heparanase	Homo sapiens	12-16
27804885-2	2017	Heparanase, an endo-beta-D-glucuronidase, is capable of specifically degrading heparan sulfate (HS), one of the excellular matrix (ECM) components.	Heparitin Sulfate	79-94	heparanase	Homo sapiens	0-10
27804885-2	2017	Heparanase, an endo-beta-D-glucuronidase, is capable of specifically degrading heparan sulfate (HS), one of the excellular matrix (ECM) components.	Heparitin Sulfate	79-94	glucuronidase beta	Homo sapiens	20-40
27804885-2	2017	Heparanase, an endo-beta-D-glucuronidase, is capable of specifically degrading heparan sulfate (HS), one of the excellular matrix (ECM) components.	Heparitin Sulfate	96-98	heparanase	Homo sapiens	0-10
27804885-2	2017	Heparanase, an endo-beta-D-glucuronidase, is capable of specifically degrading heparan sulfate (HS), one of the excellular matrix (ECM) components.	Heparitin Sulfate	96-98	glucuronidase beta	Homo sapiens	20-40
27705927-7	2016	These observations on chain length-induced specificity carry major mechanistic implications with regard to HS in cancer biology, while also presenting a novel paradigm for developing novel anti-CSC hexasaccharides that prevent cancer relapse.Heparan sulfate (HS) of specific length, i.e., hexasaccharide (HS06), but not longer or shorter sequences, selectively inhibit cancer stem cells (CSCs) through isoform specific activation of p38 mitogen-activated protein kinase.	Heparitin Sulfate	242-257	mitogen-activated protein kinase 14	Homo sapiens	433-436
27663556-5	2017	Ion mobility-mass spectrometry (IMMS) of FGF1 in the presence of several HS fragments ranging from tetrasaccharide (dp4) to dodecasaccharide (dp12) in length was performed.	Heparitin Sulfate	73-75	fibroblast growth factor 1	Homo sapiens	41-45
27558380-1	2017	Syndecan-1 (SDC1), with a variable ectodomain carrying heparan sulphate (HS) chains between different Syndecans, participates in many steps of inflammatory responses.	Heparitin Sulfate	55-71	syndecan 1	Homo sapiens	0-10
27558380-1	2017	Syndecan-1 (SDC1), with a variable ectodomain carrying heparan sulphate (HS) chains between different Syndecans, participates in many steps of inflammatory responses.	Heparitin Sulfate	55-71	syndecan 1	Homo sapiens	12-16
27558380-1	2017	Syndecan-1 (SDC1), with a variable ectodomain carrying heparan sulphate (HS) chains between different Syndecans, participates in many steps of inflammatory responses.	Heparitin Sulfate	73-75	syndecan 1	Homo sapiens	0-10
27558380-1	2017	Syndecan-1 (SDC1), with a variable ectodomain carrying heparan sulphate (HS) chains between different Syndecans, participates in many steps of inflammatory responses.	Heparitin Sulfate	73-75	syndecan 1	Homo sapiens	12-16
27558380-2	2017	In the process of proteolysis, the HS chains of the complete extracellular domain can be shed from the cell surface, by which they can mediate most of SDC1"s function.	Heparitin Sulfate	35-37	syndecan 1	Homo sapiens	151-155
27935954-3	2016	The formation of vessel sprouts, triggered by angiogenesis regulating factors with lowest affinities for heparan sulfate (e.g. VEGF), is followed by vessel-stabilizing PDGF-B or bFGF with medium affinity for HS, and by inhibitors such as PF-4 and TSP-1 with the highest affinities for HS.	Heparitin Sulfate	105-120	vascular endothelial growth factor A	Homo sapiens	127-131
27935954-3	2016	The formation of vessel sprouts, triggered by angiogenesis regulating factors with lowest affinities for heparan sulfate (e.g. VEGF), is followed by vessel-stabilizing PDGF-B or bFGF with medium affinity for HS, and by inhibitors such as PF-4 and TSP-1 with the highest affinities for HS.	Heparitin Sulfate	105-120	platelet derived growth factor subunit B	Homo sapiens	168-174
27935954-3	2016	The formation of vessel sprouts, triggered by angiogenesis regulating factors with lowest affinities for heparan sulfate (e.g. VEGF), is followed by vessel-stabilizing PDGF-B or bFGF with medium affinity for HS, and by inhibitors such as PF-4 and TSP-1 with the highest affinities for HS.	Heparitin Sulfate	105-120	fibroblast growth factor 2	Homo sapiens	178-182
28078057-3	2016	Since heparanase is a kind of endo-beta-D-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix, which further regulate the bioavailability of growth factors (FGF-2, TGF-beta).	Heparitin Sulfate	84-99	glucuronidase beta	Homo sapiens	35-55
27496765-6	2016	We identified a heparan sulfate-PG glypican-4 as a substrate for the LARGE2-dependent modification by affinity purification and subsequent mass spectrometric analysis.	Heparitin Sulfate	16-31	glypican 4	Homo sapiens	35-45
27496765-6	2016	We identified a heparan sulfate-PG glypican-4 as a substrate for the LARGE2-dependent modification by affinity purification and subsequent mass spectrometric analysis.	Heparitin Sulfate	16-31	LARGE xylosyl- and glucuronyltransferase 2	Homo sapiens	69-75
27425888-6	2016	To improve the diffusion of the growth factor neurturin (NRTN), we modified its capacity to attach to heparan sulfates in the extracellular matrix.	Heparitin Sulfate	102-118	neurturin	Homo sapiens	46-55
27425888-6	2016	To improve the diffusion of the growth factor neurturin (NRTN), we modified its capacity to attach to heparan sulfates in the extracellular matrix.	Heparitin Sulfate	102-118	neurturin	Homo sapiens	57-61
27743961-6	2016	A similar 3A mutation engineered into C2 and C41 cDNAs also improved viral replication (2-8 fold) in HeLa but the heparan sulfate mediated cell-binding enhancement by the VP1 change was C15-specific.	Heparitin Sulfate	114-129	placenta associated 8	Homo sapiens	186-189
27685787-5	2016	DAC and Aza reduced the level of glycocalyx degradation products (e.g., heparan sulfate and haluronic acid) and protected glycocalyx integrity.	Heparitin Sulfate	72-87	dachshund family transcription factor 1	Mus musculus	0-3
27714703-4	2016	METHODS: To mimic this behavior, we conjugated heparan sulfate decorated recombinant domain I of perlecan/HSPG2 onto an electrospun poly(epsilon-caprolactone) (PCL) scaffold, hypothesizing that the heparan sulfate chains will enhance rhBMP-2 loading onto the scaffold and preserve delivered rhBMP-2 bioactivity.	Heparitin Sulfate	47-62	heparan sulfate proteoglycan 2	Homo sapiens	106-111
27810711-0	2016	Obstacles and solutions for chemical synthesis of syndecan-3 (53-62) glycopeptides with two heparan sulfate chains.	Heparitin Sulfate	92-107	syndecan 3	Homo sapiens	50-60
28078057-3	2016	Since heparanase is a kind of endo-beta-D-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix, which further regulate the bioavailability of growth factors (FGF-2, TGF-beta).	Heparitin Sulfate	84-99	fibroblast growth factor 2	Homo sapiens	254-259
27810711-3	2016	In this work, we give the full account of the synthesis of syndecan-3 glycopeptide (53-62) containing two different heparan sulfate chains.	Heparitin Sulfate	116-131	syndecan 3	Homo sapiens	59-69
28078057-3	2016	Since heparanase is a kind of endo-beta-D-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix, which further regulate the bioavailability of growth factors (FGF-2, TGF-beta).	Heparitin Sulfate	84-99	transforming growth factor beta 1	Homo sapiens	261-269
27666777-1	2016	Heparanase, the only known mammalian endoglycosidase degrading heparan sulfate (HS) chains of HS proteoglycans (HSPG), is a highly versatile protein affecting multiple events in tumor cells and their microenvironment.	Heparitin Sulfate	63-78	heparanase	Homo sapiens	0-10
27666777-1	2016	Heparanase, the only known mammalian endoglycosidase degrading heparan sulfate (HS) chains of HS proteoglycans (HSPG), is a highly versatile protein affecting multiple events in tumor cells and their microenvironment.	Heparitin Sulfate	80-82	heparanase	Homo sapiens	0-10
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Heparitin Sulfate	42-57	melanoma antigen	Mus musculus	4-7
27699767-2	2016	We sought to determine whether polymorphisms of the glucuronic acid epimerase (GLCE) rs3865014 and sulfatase-2 (SULF2) rs2281279, genes coding for enzymes participating in heparan sulfate side chain activity, associate with hypertension, selected cardiometabolic risk factors and cardiovascular events in the Tampere adult population cardiovascular risk study.	Heparitin Sulfate	172-187	glucuronic acid epimerase	Homo sapiens	79-83
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Heparitin Sulfate	59-61	melanoma antigen	Mus musculus	4-7
27699767-2	2016	We sought to determine whether polymorphisms of the glucuronic acid epimerase (GLCE) rs3865014 and sulfatase-2 (SULF2) rs2281279, genes coding for enzymes participating in heparan sulfate side chain activity, associate with hypertension, selected cardiometabolic risk factors and cardiovascular events in the Tampere adult population cardiovascular risk study.	Heparitin Sulfate	172-187	sulfatase 2	Homo sapiens	99-110
27699767-2	2016	We sought to determine whether polymorphisms of the glucuronic acid epimerase (GLCE) rs3865014 and sulfatase-2 (SULF2) rs2281279, genes coding for enzymes participating in heparan sulfate side chain activity, associate with hypertension, selected cardiometabolic risk factors and cardiovascular events in the Tampere adult population cardiovascular risk study.	Heparitin Sulfate	172-187	sulfatase 2	Homo sapiens	112-117
27898729-7	2016	We found that these GAG extracts were heavily contaminated with RNA, which co-migrated with HS in barium acetate gel electrophoresis and interfered with 1,9-dimethylmethylene blue (DMMB) assays, resulting in an overestimation of GAG yields.	Heparitin Sulfate	92-94	melanoma antigen	Mus musculus	20-23
27653286-0	2016	Structural Aspects of Heparan Sulfate Binding to Robo1-Ig1-2.	Heparitin Sulfate	22-37	roundabout guidance receptor 1	Homo sapiens	49-60
27697839-0	2016	Heparan Sulfate Regulates the Structure and Function of Osteoprotegerin in Osteoclastogenesis.	Heparitin Sulfate	0-15	TNF receptor superfamily member 11b	Homo sapiens	56-71
27697839-3	2016	OPG is known to be a high-affinity heparan sulfate (HS)-binding protein.	Heparitin Sulfate	35-50	TNF receptor superfamily member 11b	Homo sapiens	0-3
27697839-3	2016	OPG is known to be a high-affinity heparan sulfate (HS)-binding protein.	Heparitin Sulfate	52-54	TNF receptor superfamily member 11b	Homo sapiens	0-3
27697839-4	2016	Presumably, HS could regulate the function of OPG and affect how it inhibits RANKL.	Heparitin Sulfate	12-14	TNF receptor superfamily member 11b	Homo sapiens	46-49
27697839-4	2016	Presumably, HS could regulate the function of OPG and affect how it inhibits RANKL.	Heparitin Sulfate	12-14	TNF superfamily member 11	Homo sapiens	77-82
27697839-11	2016	Using a HS binding-deficient OPG mutant, we further show that in an osteoblast/bone marrow macrophage co-culture system, immobilization of OPG by HS at the osteoblast cell surface substantially lowers the inhibitory threshold of OPG toward RANKL.	Heparitin Sulfate	8-10	TNF receptor superfamily member 11b	Homo sapiens	29-32
27697839-11	2016	Using a HS binding-deficient OPG mutant, we further show that in an osteoblast/bone marrow macrophage co-culture system, immobilization of OPG by HS at the osteoblast cell surface substantially lowers the inhibitory threshold of OPG toward RANKL.	Heparitin Sulfate	8-10	TNF receptor superfamily member 11b	Homo sapiens	139-142
27697839-11	2016	Using a HS binding-deficient OPG mutant, we further show that in an osteoblast/bone marrow macrophage co-culture system, immobilization of OPG by HS at the osteoblast cell surface substantially lowers the inhibitory threshold of OPG toward RANKL.	Heparitin Sulfate	8-10	TNF receptor superfamily member 11b	Homo sapiens	139-142
27697839-11	2016	Using a HS binding-deficient OPG mutant, we further show that in an osteoblast/bone marrow macrophage co-culture system, immobilization of OPG by HS at the osteoblast cell surface substantially lowers the inhibitory threshold of OPG toward RANKL.	Heparitin Sulfate	146-148	TNF receptor superfamily member 11b	Homo sapiens	29-32
27697839-11	2016	Using a HS binding-deficient OPG mutant, we further show that in an osteoblast/bone marrow macrophage co-culture system, immobilization of OPG by HS at the osteoblast cell surface substantially lowers the inhibitory threshold of OPG toward RANKL.	Heparitin Sulfate	146-148	TNF receptor superfamily member 11b	Homo sapiens	139-142
27697839-11	2016	Using a HS binding-deficient OPG mutant, we further show that in an osteoblast/bone marrow macrophage co-culture system, immobilization of OPG by HS at the osteoblast cell surface substantially lowers the inhibitory threshold of OPG toward RANKL.	Heparitin Sulfate	146-148	TNF receptor superfamily member 11b	Homo sapiens	139-142
27697839-11	2016	Using a HS binding-deficient OPG mutant, we further show that in an osteoblast/bone marrow macrophage co-culture system, immobilization of OPG by HS at the osteoblast cell surface substantially lowers the inhibitory threshold of OPG toward RANKL.	Heparitin Sulfate	146-148	TNF superfamily member 11	Homo sapiens	240-245
27697839-12	2016	These discoveries strongly suggest that HS plays an active role in regulating OPG-RANKL interaction and osteoclastogenesis.	Heparitin Sulfate	40-42	TNF receptor superfamily member 11b	Homo sapiens	78-81
27697839-12	2016	These discoveries strongly suggest that HS plays an active role in regulating OPG-RANKL interaction and osteoclastogenesis.	Heparitin Sulfate	40-42	TNF superfamily member 11	Homo sapiens	82-87
27576132-1	2016	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate side chains contributing to breakdown of the extracellular matrix.	Heparitin Sulfate	63-78	glucuronidase beta	Homo sapiens	22-42
27445159-4	2016	The recombinantly expressed serglycin produced with 25mM glucose present in the culture medium was found to possess anticoagulant activity one-seventh of that of porcine unfractionated heparin, demonstrating that bioengineered human heparin-like heparan sulfate may be a safe next-generation pharmaceutical heparin.	Heparitin Sulfate	246-261	serglycin	Homo sapiens	28-37
27445159-2	2016	Here we report the biosynthesis of heparin-like heparan sulfate via the recombinant expression of human serglycin in human cells.	Heparitin Sulfate	48-63	serglycin	Homo sapiens	104-113
27803285-0	2016	Heparan sulfate differentially controls CXCL12alpha- and CXCL12gamma-mediated cell migration through differential presentation to their receptor CXCR4.	Heparitin Sulfate	0-15	C-X-C motif chemokine receptor 4	Homo sapiens	145-150
27748933-3	2016	The proteins EXT1 and EXT2 form a hetero-oligomeric complex that functions in heparan sulfate proteoglycan biosynthesis.	Heparitin Sulfate	78-93	exostosin glycosyltransferase 1	Homo sapiens	13-17
27748933-3	2016	The proteins EXT1 and EXT2 form a hetero-oligomeric complex that functions in heparan sulfate proteoglycan biosynthesis.	Heparitin Sulfate	78-93	exostosin glycosyltransferase 2	Homo sapiens	22-26
27783649-7	2016	Further, we found that exosome-fibronectin binding is heparan sulfate-dependent, consistent with our observation that trabecular meshwork exosomes are enriched in the heparin/heparan sulfate binding annexins A2 and A6.	Heparitin Sulfate	54-69	fibronectin 1	Homo sapiens	31-42
27788205-0	2016	A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.	Heparitin Sulfate	81-96	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	132-137
27788205-0	2016	A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.	Heparitin Sulfate	81-96	MHC class I antigen 1	Sus scrofa	192-196
27783649-7	2016	Further, we found that exosome-fibronectin binding is heparan sulfate-dependent, consistent with our observation that trabecular meshwork exosomes are enriched in the heparin/heparan sulfate binding annexins A2 and A6.	Heparitin Sulfate	175-190	fibronectin 1	Homo sapiens	31-42
27779234-9	2016	However, cells overexpressing full-length ADAMTS6 lack heparan sulphate and focal adhesions, whilst depletion of ADAMTS6 induces a prominent glycocalyx.	Heparitin Sulfate	55-71	ADAM metallopeptidase with thrombospondin type 1 motif 6	Homo sapiens	42-49
27779234-10	2016	Thus ADAMTS10 and ADAMTS6 oppositely affect heparan sulphate-rich interfaces including focal adhesions.	Heparitin Sulfate	44-60	ADAM metallopeptidase with thrombospondin type 1 motif 10	Homo sapiens	5-13
27779234-10	2016	Thus ADAMTS10 and ADAMTS6 oppositely affect heparan sulphate-rich interfaces including focal adhesions.	Heparitin Sulfate	44-60	ADAM metallopeptidase with thrombospondin type 1 motif 6	Homo sapiens	18-25
27779234-12	2016	Here we reveal that ADAMTS6 causes a reduction in heparan sulphate-rich interfaces, and its expression is regulated by ADAMTS10.	Heparitin Sulfate	50-66	ADAM metallopeptidase with thrombospondin type 1 motif 6	Homo sapiens	20-27
27779234-12	2016	Here we reveal that ADAMTS6 causes a reduction in heparan sulphate-rich interfaces, and its expression is regulated by ADAMTS10.	Heparitin Sulfate	50-66	ADAM metallopeptidase with thrombospondin type 1 motif 10	Homo sapiens	119-127
27711215-4	2016	Among them are exogenous heparins, which are strong hepcidin repressors with a mechanism of action not fully understood but that may involve the competition with the structurally similar endogenous Heparan Sulfates (HS).	Heparitin Sulfate	198-214	hepcidin antimicrobial peptide	Mus musculus	52-60
27768722-0	2016	The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling.	Heparitin Sulfate	4-19	glypican 6	Homo sapiens	33-43
27768722-0	2016	The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling.	Heparitin Sulfate	4-19	mitogen-activated protein kinase 3	Homo sapiens	124-130
27768722-4	2016	Here we investigated glypicans (GPC1-6), a family of evolutionary conserved heparan sulfate proteoglycans anchored to the extracellular leaflet of the cell membrane, in experimental and clinical heart failure, and explored the function of glypican-6 in cardiac cells in vitro.	Heparitin Sulfate	76-91	glypican 1	Homo sapiens	32-38
27784961-1	2016	Currently, hepatitis B virus (HBV), upon attaching to human hepatocytes, is considered to interact first with heparan sulfate proteoglycan (HSPG) via an antigenic loop of HBV envelope S protein.	Heparitin Sulfate	110-125	syndecan 2	Homo sapiens	140-144
27502551-1	2016	Heparin/heparan sulfate (HS) glycosaminoglycans are required for Slit-Robo cellular responses.	Heparitin Sulfate	8-23	roundabout 1	Drosophila melanogaster	70-74
27711215-4	2016	Among them are exogenous heparins, which are strong hepcidin repressors with a mechanism of action not fully understood but that may involve the competition with the structurally similar endogenous Heparan Sulfates (HS).	Heparitin Sulfate	216-218	hepcidin antimicrobial peptide	Mus musculus	52-60
27694984-5	2016	Upon SNx, extracellular TG2 deposited in the tubulointerstitium and peri-glomerulus via binding to heparan sulphate (HS) chains of proteoglycans and co-associated with syndecan-4.	Heparitin Sulfate	99-115	transglutaminase 2	Rattus norvegicus	24-27
27611601-0	2016	Integrated Approach to Identify Heparan Sulfate Ligand Requirements of Robo1.	Heparitin Sulfate	32-47	roundabout guidance receptor 1	Homo sapiens	71-76
27240275-1	2016	Heparanase, an only endo-beta-d-glucuronidase capable of cleaving heparan sulfate (HS) side chains at specific sites, contributes to remodeling of the extracellular matrix (ECM) and releasing of HS-linked growth factors, cytokines and signaling proteins.	Heparitin Sulfate	66-81	glucuronidase beta	Homo sapiens	25-45
27240275-1	2016	Heparanase, an only endo-beta-d-glucuronidase capable of cleaving heparan sulfate (HS) side chains at specific sites, contributes to remodeling of the extracellular matrix (ECM) and releasing of HS-linked growth factors, cytokines and signaling proteins.	Heparitin Sulfate	83-85	glucuronidase beta	Homo sapiens	25-45
27694984-5	2016	Upon SNx, extracellular TG2 deposited in the tubulointerstitium and peri-glomerulus via binding to heparan sulphate (HS) chains of proteoglycans and co-associated with syndecan-4.	Heparitin Sulfate	117-119	transglutaminase 2	Rattus norvegicus	24-27
27677855-0	2016	Independent multimerization of Latent TGFbeta Binding Protein-1 stabilized by cross-linking and enhanced by heparan sulfate.	Heparitin Sulfate	108-123	transforming growth factor beta 1	Homo sapiens	38-45
27387504-0	2016	NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length.	Heparitin Sulfate	60-75	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	0-5
27650265-4	2016	In cultured cell lines, the EXT1 and EXT2 enzymes, initiating HS biosynthesis, were stimulated at the translational level by polyamines.	Heparitin Sulfate	62-64	exostosin glycosyltransferase 1	Homo sapiens	28-32
27650265-4	2016	In cultured cell lines, the EXT1 and EXT2 enzymes, initiating HS biosynthesis, were stimulated at the translational level by polyamines.	Heparitin Sulfate	62-64	exostosin glycosyltransferase 2	Homo sapiens	37-41
27627962-5	2016	Because fibroblast growth factor 22 (FGF22), a heparan sulfate binding growth factor, has been shown to act as a presynaptic organizer released from the postsynaptic site, it seems possible that postsynaptic SDC2 presents FGF22 to the presynaptic FGF receptor to promote presynaptic differentiation.	Heparitin Sulfate	47-62	fibroblast growth factor 22	Homo sapiens	8-35
27627962-5	2016	Because fibroblast growth factor 22 (FGF22), a heparan sulfate binding growth factor, has been shown to act as a presynaptic organizer released from the postsynaptic site, it seems possible that postsynaptic SDC2 presents FGF22 to the presynaptic FGF receptor to promote presynaptic differentiation.	Heparitin Sulfate	47-62	fibroblast growth factor 22	Homo sapiens	37-42
27627962-5	2016	Because fibroblast growth factor 22 (FGF22), a heparan sulfate binding growth factor, has been shown to act as a presynaptic organizer released from the postsynaptic site, it seems possible that postsynaptic SDC2 presents FGF22 to the presynaptic FGF receptor to promote presynaptic differentiation.	Heparitin Sulfate	47-62	syndecan 2	Homo sapiens	208-212
27387504-0	2016	NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length.	Heparitin Sulfate	60-75	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	7-41
27387504-1	2016	Analysis of heparan sulfate synthesized by HEK 293 cells overexpressing murine NDST1 and/or NDST2 demonstrated that the amount of heparan sulfate was increased in NDST2- but not in NDST1-overexpressing cells.	Heparitin Sulfate	12-27	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	79-84
27387504-1	2016	Analysis of heparan sulfate synthesized by HEK 293 cells overexpressing murine NDST1 and/or NDST2 demonstrated that the amount of heparan sulfate was increased in NDST2- but not in NDST1-overexpressing cells.	Heparitin Sulfate	130-145	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	79-84
27387504-1	2016	Analysis of heparan sulfate synthesized by HEK 293 cells overexpressing murine NDST1 and/or NDST2 demonstrated that the amount of heparan sulfate was increased in NDST2- but not in NDST1-overexpressing cells.	Heparitin Sulfate	130-145	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	92-97
27387504-1	2016	Analysis of heparan sulfate synthesized by HEK 293 cells overexpressing murine NDST1 and/or NDST2 demonstrated that the amount of heparan sulfate was increased in NDST2- but not in NDST1-overexpressing cells.	Heparitin Sulfate	130-145	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	163-168
27387504-3	2016	However, the role of NDST2 in regulating the amount of heparan sulfate synthesized was confirmed by analyzing heparan sulfate content in tissues isolated from Ndst2(-/-) mice, which contained reduced levels of the polysaccharide.	Heparitin Sulfate	55-70	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	21-26
27387504-5	2016	In vivo transcript expression levels of the heparan sulfate-polymerizing enzymes Ext1 and Ext2 were also largely unaffected by NDST2 levels, pointing to a mode of regulation other than increased gene transcription.	Heparitin Sulfate	44-59	exostosin glycosyltransferase 1	Mus musculus	81-85
27387504-5	2016	In vivo transcript expression levels of the heparan sulfate-polymerizing enzymes Ext1 and Ext2 were also largely unaffected by NDST2 levels, pointing to a mode of regulation other than increased gene transcription.	Heparitin Sulfate	44-59	exostosin glycosyltransferase 2	Mus musculus	90-94
27387504-6	2016	Size estimation of heparan sulfate polysaccharide chains indicated that increased chain lengths in NDST2-overexpressing cells alone could explain the increased heparan sulfate content.	Heparitin Sulfate	19-34	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	99-104
27387504-7	2016	A model is discussed where NDST2-specific substrate modification stimulates elongation resulting in increased heparan sulfate chain length.	Heparitin Sulfate	110-125	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	27-32
27828631-1	2016	Background:: Heparanase is an enzyme that cleaves heparan sulfate chains.	Heparitin Sulfate	50-65	heparanase	Homo sapiens	13-23
27291973-6	2016	The optimum N/L/P ratio of 20:33:10 was chosen for microencapsulation of anti-VEGF siRNA by ethanol drop method, showing particle size of 130nm, zeta-potential of +4mV, siRNA loading efficiency and capacity of 96% and 13wt%, and high stability against heparin sulfate (extracellular matrix).	Heparitin Sulfate	252-267	vascular endothelial growth factor A	Homo sapiens	78-82
27491071-1	2016	Mucopolysaccharidosis type IIIC (MPSIIIC) is a severe lysosomal storage disease caused by deficiency in activity of the transmembrane enzyme heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT) that catalyses the N-acetylation of alpha-glucosamine residues of heparan sulfate.	Heparitin Sulfate	264-279	heparan-alpha-glucosaminide N-acetyltransferase	Mus musculus	141-188
27491071-1	2016	Mucopolysaccharidosis type IIIC (MPSIIIC) is a severe lysosomal storage disease caused by deficiency in activity of the transmembrane enzyme heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT) that catalyses the N-acetylation of alpha-glucosamine residues of heparan sulfate.	Heparitin Sulfate	264-279	heparan-alpha-glucosaminide N-acetyltransferase	Mus musculus	190-196
27151304-7	2016	S100A8/A9 mediates its effects by binding to cell surface receptors, such as heparan sulfate, TLR4 and RAGE on immune and tumor cells.	Heparitin Sulfate	77-92	S100 calcium binding protein A8	Homo sapiens	0-9
27511124-1	2016	Biosynthesis of heparan sulfate (HS) involves conversion of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) units catalyzed by glucuronyl C5-epimerase (Hsepi).	Heparitin Sulfate	16-31	glucuronic acid epimerase	Homo sapiens	155-160
27511124-1	2016	Biosynthesis of heparan sulfate (HS) involves conversion of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) units catalyzed by glucuronyl C5-epimerase (Hsepi).	Heparitin Sulfate	33-35	glucuronic acid epimerase	Homo sapiens	155-160
27511124-4	2016	Overexpression of Hsepi alone resulted in an unexpected increase in HS chain length.	Heparitin Sulfate	68-70	glucuronic acid epimerase	Homo sapiens	18-23
27853671-6	2016	Heparan sulfate promotes effective protein-protein interactions, thereby facilitating the assembly of type VII collagen anchoring fibrils and elastin-associated microfibrils.	Heparitin Sulfate	0-15	elastin	Homo sapiens	142-149
27382052-3	2016	Key steps of this process are (i) phosphoinositide-dependent membrane recruitment, (ii) FGF2 oligomerization and membrane pore formation, and (iii) extracellular trapping mediated by membrane-proximal heparan sulfate proteoglycans.	Heparitin Sulfate	201-216	fibroblast growth factor 2	Homo sapiens	88-92
27061054-0	2016	The BDLF3 gene product of Epstein-Barr virus, gp150, mediates non-productive binding to heparan sulfate on epithelial cells and only the binding domain of CD21 is required for infection.	Heparitin Sulfate	88-103	envelope glycoprotein 150	Human gammaherpesvirus 4	4-9
27225479-4	2016	METHODS AND RESULTS: Lymphatic endothelial deficiency in the major heparan sulfate biosynthetic enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1; involved in glycan-chain sulfation) was associated with reduced lymphangiogenesis in pathological models, including spontaneous neoplasia.	Heparitin Sulfate	67-82	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	103-137
27225479-4	2016	METHODS AND RESULTS: Lymphatic endothelial deficiency in the major heparan sulfate biosynthetic enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1; involved in glycan-chain sulfation) was associated with reduced lymphangiogenesis in pathological models, including spontaneous neoplasia.	Heparitin Sulfate	67-82	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	139-144
27990411-5	2016	The cell adhesion to LL-37 was partially inhibited by specific Mac-1 antagonists, including mAb against the alphaM integrin subunit and neutrophil inhibitory factor, and completely blocked when anti-Mac-1 antibodies were combined with heparin, suggesting that cell surface heparan sulfate proteoglycans act cooperatively with integrin Mac-1.	Heparitin Sulfate	273-288	integrin subunit alpha M	Homo sapiens	63-68
27350175-7	2016	INF2 mutant podocytes do show impaired reversal of protamine sulfate-induced foot process effacement by heparin sulfate perfusion.	Heparitin Sulfate	104-119	inverted formin, FH2 and WH2 domain containing	Mus musculus	0-4
27545212-2	2016	The G allele of the HSPG2-rs3767140 may affect the binding of heparan sulfate (HS) chains and hence cause loss of HS from the basement membrane.	Heparitin Sulfate	62-77	heparan sulfate proteoglycan 2	Homo sapiens	20-25
27545212-2	2016	The G allele of the HSPG2-rs3767140 may affect the binding of heparan sulfate (HS) chains and hence cause loss of HS from the basement membrane.	Heparitin Sulfate	79-81	heparan sulfate proteoglycan 2	Homo sapiens	20-25
27990411-5	2016	The cell adhesion to LL-37 was partially inhibited by specific Mac-1 antagonists, including mAb against the alphaM integrin subunit and neutrophil inhibitory factor, and completely blocked when anti-Mac-1 antibodies were combined with heparin, suggesting that cell surface heparan sulfate proteoglycans act cooperatively with integrin Mac-1.	Heparitin Sulfate	273-288	cathelicidin antimicrobial peptide	Homo sapiens	21-26
26762172-1	2016	Heparanase is a beta-d-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes.	Heparitin Sulfate	51-66	heparanase	Homo sapiens	0-10
27113165-11	2016	We attribute the timing effect to a conformational change in HPV virions, thought to occur upon initial binding to heparan sulfate proteoglycans (HSPG) on the cell surface.	Heparitin Sulfate	115-130	syndecan 2	Homo sapiens	146-150
25998837-1	2016	MPS IIIC stands out among lysosomal diseases because it is the only one caused by a deficiency not of a hydrolase but of HGSNAT (heparan--glucosaminide N-acetyltransferase), which catalyzes acetylation of glycosaminoglycan heparan sulfate (HS) prior to its hydrolysis.	Heparitin Sulfate	223-238	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	121-127
25998837-1	2016	MPS IIIC stands out among lysosomal diseases because it is the only one caused by a deficiency not of a hydrolase but of HGSNAT (heparan--glucosaminide N-acetyltransferase), which catalyzes acetylation of glycosaminoglycan heparan sulfate (HS) prior to its hydrolysis.	Heparitin Sulfate	223-238	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	129-171
25998837-1	2016	MPS IIIC stands out among lysosomal diseases because it is the only one caused by a deficiency not of a hydrolase but of HGSNAT (heparan--glucosaminide N-acetyltransferase), which catalyzes acetylation of glycosaminoglycan heparan sulfate (HS) prior to its hydrolysis.	Heparitin Sulfate	240-242	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	121-127
25998837-1	2016	MPS IIIC stands out among lysosomal diseases because it is the only one caused by a deficiency not of a hydrolase but of HGSNAT (heparan--glucosaminide N-acetyltransferase), which catalyzes acetylation of glycosaminoglycan heparan sulfate (HS) prior to its hydrolysis.	Heparitin Sulfate	240-242	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	129-171
27129145-1	2016	Heparanase is an endo-glucuronidase that specifically cleaves heparan sulfate (HS) and heparin polysaccharides.	Heparitin Sulfate	62-77	heparanase	Homo sapiens	0-10
27129145-1	2016	Heparanase is an endo-glucuronidase that specifically cleaves heparan sulfate (HS) and heparin polysaccharides.	Heparitin Sulfate	79-81	heparanase	Homo sapiens	0-10
27255651-4	2016	We demonstrated here that the branched peptide NT4 binds sulfated glycosaminoglycans with high affinity and with preferential binding to heparan sulfate.	Heparitin Sulfate	137-152	neurotrophin 4	Homo sapiens	47-50
26791445-1	2016	There is a functional relationship between the heparan sulfate proteoglycan glypican-1 and the amyloid precursor protein (APP) of Alzheimer disease.	Heparitin Sulfate	47-62	glypican 1	Mus musculus	76-86
26791445-1	2016	There is a functional relationship between the heparan sulfate proteoglycan glypican-1 and the amyloid precursor protein (APP) of Alzheimer disease.	Heparitin Sulfate	47-62	amyloid beta (A4) precursor protein	Mus musculus	95-120
26791445-2	2016	In wild-type mouse embryonic fibroblasts, expression and processing of the APP is required for endosome-to-nucleus translocation of anhydromannose-containing heparan sulfate released from S-nitrosylated glypican-1 by ascorbate-induced, nitrosothiol-catalyzed deaminative cleavage.	Heparitin Sulfate	158-173	glypican 1	Mus musculus	203-213
27098652-0	2016	The heparan sulphate deficient Hspg2 exon 3 null mouse displays reduced deposition of TGF-beta1 in skin compared to C57BL/6 wild type mice.	Heparitin Sulfate	4-20	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	31-36
27015605-10	2016	Taken together, in a dorsal air pouch inflammation model heparastatin (SF4) potentially suppresses extravasation of inflammatory cells by impairing the degradation of basement membrane heparan sulfate.	Heparitin Sulfate	185-200	SURP and G patch domain containing 1	Mus musculus	71-74
27098652-0	2016	The heparan sulphate deficient Hspg2 exon 3 null mouse displays reduced deposition of TGF-beta1 in skin compared to C57BL/6 wild type mice.	Heparitin Sulfate	4-20	transforming growth factor, beta 1	Mus musculus	86-95
26945629-8	2016	Analysis of the native SAA1.1 structure has led to the identification of a competing site for high-density lipoprotein (HDL) and heparin, thus providing the structural basis for a role of heparin and heparan sulfate in the conversion of SAA1 to AA.	Heparitin Sulfate	200-215	serum amyloid A1	Homo sapiens	23-27
27064211-5	2016	An immunoprecipitation method together with liquid chromatography-tandem mass spectrometry showed that alpha-N-acetylglucosaminidase (Naglu; a degradation enzyme of heparan sulfate) is one of the glycoproteins recognized by Ts4 in the epididymal spermatozoa.	Heparitin Sulfate	165-180	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	103-132
27064211-5	2016	An immunoprecipitation method together with liquid chromatography-tandem mass spectrometry showed that alpha-N-acetylglucosaminidase (Naglu; a degradation enzyme of heparan sulfate) is one of the glycoproteins recognized by Ts4 in the epididymal spermatozoa.	Heparitin Sulfate	165-180	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	134-139
27064211-5	2016	An immunoprecipitation method together with liquid chromatography-tandem mass spectrometry showed that alpha-N-acetylglucosaminidase (Naglu; a degradation enzyme of heparan sulfate) is one of the glycoproteins recognized by Ts4 in the epididymal spermatozoa.	Heparitin Sulfate	165-180	Trichinella spiralis resistance 4	Mus musculus	224-227
27064211-9	2016	In addition, Ts4 inhibited sperm acrosome reaction induced by heparan sulfate.	Heparitin Sulfate	62-77	Trichinella spiralis resistance 4	Mus musculus	13-16
26331342-10	2016	Both the SD-OCT and the electroretinogram changes appear attributable to intraretinal deposition of heparan sulfate.	Heparitin Sulfate	100-115	plexin A2	Homo sapiens	12-15
26945629-8	2016	Analysis of the native SAA1.1 structure has led to the identification of a competing site for high-density lipoprotein (HDL) and heparin, thus providing the structural basis for a role of heparin and heparan sulfate in the conversion of SAA1 to AA.	Heparitin Sulfate	200-215	serum amyloid A1	Homo sapiens	237-241
26936875-0	2016	N-sulfation of heparan sulfate is critical for syndecan-4-mediated podocyte cell-matrix interactions.	Heparitin Sulfate	15-30	syndecan 4	Mus musculus	47-57
27199253-0	2016	Bridging the gap: heparan sulfate and Scube2 assemble Sonic hedgehog release complexes at the surface of producing cells.	Heparitin Sulfate	18-33	sonic hedgehog signaling molecule	Homo sapiens	54-68
27151330-0	2016	Apolipoprotein E lipoprotein particles inhibit amyloid-beta uptake through cell surface heparan sulphate proteoglycan.	Heparitin Sulfate	88-104	apolipoprotein E	Cricetulus griseus	0-16
27151330-4	2016	Heparan sulphate proteoglycans (HSPGs) are abundant cell surface molecules that bind to both apoE and Abeta.	Heparitin Sulfate	0-16	apolipoprotein E	Cricetulus griseus	93-97
27151330-4	2016	Heparan sulphate proteoglycans (HSPGs) are abundant cell surface molecules that bind to both apoE and Abeta.	Heparitin Sulfate	0-16	amyloid beta (A4) precursor protein	Mus musculus	102-107
26907177-1	2016	BACKGROUND: Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare genetic disorder in which the deficiency of the lysosomal enzyme N-acetyl-alpha-glucosaminidase (NAGLU) results in the accumulation of heparan sulfate (HS), leading to progressive neurocognitive deterioration.	Heparitin Sulfate	200-215	N-acetyl-alpha-glucosaminidase	Homo sapiens	45-53
26920026-6	2016	Cell attachment to PRELP was inhibited by addition of soluble heparin or heparan sulfate (HS), by blocking sulfation of the fibroblasts or by treating the cells with a combination of chondroitinase and heparinase.	Heparitin Sulfate	73-88	proline and arginine rich end leucine rich repeat protein	Rattus norvegicus	19-24
26920026-6	2016	Cell attachment to PRELP was inhibited by addition of soluble heparin or heparan sulfate (HS), by blocking sulfation of the fibroblasts or by treating the cells with a combination of chondroitinase and heparinase.	Heparitin Sulfate	90-92	proline and arginine rich end leucine rich repeat protein	Rattus norvegicus	19-24
27013193-2	2016	Heparanase-2 (Hpa2) is a close homolog of heparanase that lacks intrinsic HS-degrading activity but retains the capacity to bind HS with high affinity.	Heparitin Sulfate	74-76	heparanase 2 (inactive)	Homo sapiens	0-12
27013193-2	2016	Heparanase-2 (Hpa2) is a close homolog of heparanase that lacks intrinsic HS-degrading activity but retains the capacity to bind HS with high affinity.	Heparitin Sulfate	74-76	heparanase 2 (inactive)	Homo sapiens	14-18
26975339-5	2016	Vector-derived SGSH enzyme improved heparan sulfate catabolism, reduced microglial activation, and, after a time delay, ameliorated GM3 ganglioside accumulation and halted ubiquitin-positive lesion formation in regions local to, or connected by projections to, the injection site.	Heparitin Sulfate	36-51	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	15-19
26987844-8	2016	In all these cell types, VEGF-C was found associated with the cell membrane by low affinity, heparan sulphate-mediated, interactions.	Heparitin Sulfate	93-109	vascular endothelial growth factor C	Homo sapiens	25-31
26907177-1	2016	BACKGROUND: Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare genetic disorder in which the deficiency of the lysosomal enzyme N-acetyl-alpha-glucosaminidase (NAGLU) results in the accumulation of heparan sulfate (HS), leading to progressive neurocognitive deterioration.	Heparitin Sulfate	200-215	N-acetyl-alpha-glucosaminidase	Homo sapiens	130-160
26907177-1	2016	BACKGROUND: Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare genetic disorder in which the deficiency of the lysosomal enzyme N-acetyl-alpha-glucosaminidase (NAGLU) results in the accumulation of heparan sulfate (HS), leading to progressive neurocognitive deterioration.	Heparitin Sulfate	200-215	N-acetyl-alpha-glucosaminidase	Homo sapiens	162-167
26907177-1	2016	BACKGROUND: Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare genetic disorder in which the deficiency of the lysosomal enzyme N-acetyl-alpha-glucosaminidase (NAGLU) results in the accumulation of heparan sulfate (HS), leading to progressive neurocognitive deterioration.	Heparitin Sulfate	217-219	N-acetyl-alpha-glucosaminidase	Homo sapiens	45-53
26907177-1	2016	BACKGROUND: Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare genetic disorder in which the deficiency of the lysosomal enzyme N-acetyl-alpha-glucosaminidase (NAGLU) results in the accumulation of heparan sulfate (HS), leading to progressive neurocognitive deterioration.	Heparitin Sulfate	217-219	N-acetyl-alpha-glucosaminidase	Homo sapiens	130-160
26907177-1	2016	BACKGROUND: Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare genetic disorder in which the deficiency of the lysosomal enzyme N-acetyl-alpha-glucosaminidase (NAGLU) results in the accumulation of heparan sulfate (HS), leading to progressive neurocognitive deterioration.	Heparitin Sulfate	217-219	N-acetyl-alpha-glucosaminidase	Homo sapiens	162-167
27199983-7	2016	Whereas podocytes are protected by cell-bound regulators, the GBM must recruit plasma factor H, which inhibits the AP on host surfaces carrying certain polyanions, such as heparan sulfate (HS) chains.	Heparitin Sulfate	172-187	complement factor H	Homo sapiens	86-94
27237321-4	2016	Herein, we show that targeting of DC glycan sulfation through mutation in the heparan sulfate biosynthetic enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1) in mice increased DC maturation and inhibited trafficking of DCs to draining lymph nodes.	Heparitin Sulfate	78-93	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	114-148
27237321-4	2016	Herein, we show that targeting of DC glycan sulfation through mutation in the heparan sulfate biosynthetic enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1) in mice increased DC maturation and inhibited trafficking of DCs to draining lymph nodes.	Heparitin Sulfate	78-93	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	150-155
27237321-10	2016	These findings indicate the genetic importance of DC heparan sulfate proteoglycans in tumor growth and may guide therapeutic development of novel strategies to target syndecan-4 and heparan sulfate in cancer.	Heparitin Sulfate	53-68	syndecan 4	Mus musculus	167-177
27063019-1	2016	3-O-Sulfotransferase (3-OST) is one of the enzymes involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	63-78	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	0-20
27063019-1	2016	3-O-Sulfotransferase (3-OST) is one of the enzymes involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	63-78	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	22-27
27063019-1	2016	3-O-Sulfotransferase (3-OST) is one of the enzymes involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	80-82	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	0-20
27063019-1	2016	3-O-Sulfotransferase (3-OST) is one of the enzymes involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	80-82	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	22-27
27063019-3	2016	3-OST is responsible for the transfer of a sulfate group from 3"-phosphoadenosine-5"-phosphosulfate (PAPS) to glucosamine units of HS.	Heparitin Sulfate	131-133	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	0-5
27063019-8	2016	The results show that the reaction mechanism of 3-OST occurs by a single elementary step, consisting of an associative SN2 transfer of the sulfate group from PAPS to the HS glucosamine units, with the transfer of a proton from glucosamine to the catalytic Glu184.	Heparitin Sulfate	170-172	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	48-53
27199983-7	2016	Whereas podocytes are protected by cell-bound regulators, the GBM must recruit plasma factor H, which inhibits the AP on host surfaces carrying certain polyanions, such as heparan sulfate (HS) chains.	Heparitin Sulfate	189-191	complement factor H	Homo sapiens	86-94
26636652-1	2016	OBJECTIVE: To investigate the role of the heparan sulfate (HS) proteoglycan perlecan (HSPG-2) in regulating fibroblast growth factor (FGF) activity, bone and joint growth, and the onset and progression of posttraumatic osteoarthritis (OA) in a mouse gene-knockout model.	Heparitin Sulfate	42-57	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	86-92
27331006-10	2016	Among patients who received ERT with confirmed elevation of antibody titer, the concentrations of HS in the urine of patients with attenuated type were lower than those with severe type of MPS II.	Heparitin Sulfate	98-100	E74 like ETS transcription factor 3	Homo sapiens	28-31
26731579-0	2016	Expanding the 3-O-Sulfate Proteome--Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity.	Heparitin Sulfate	85-100	neuropilin 1	Mus musculus	56-68
26731579-4	2016	Fractionation of different animal sera yielded several proteins that bound specifically to columns containing 3-O-sulfated heparan sulfate modified by two members of the heparan sulfate 3-O-sulfotransferase superfamily, Hs3st1 and Hs3st2.	Heparitin Sulfate	123-138	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	Mus musculus	220-226
26731579-4	2016	Fractionation of different animal sera yielded several proteins that bound specifically to columns containing 3-O-sulfated heparan sulfate modified by two members of the heparan sulfate 3-O-sulfotransferase superfamily, Hs3st1 and Hs3st2.	Heparitin Sulfate	123-138	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	Mus musculus	231-237
26731579-6	2016	We show that 3-O-sulfation enhanced the binding of neuropilin-1 to heparan sulfate immobilized on plastic plates and to heparan sulfate present on cultured cells.	Heparitin Sulfate	67-82	neuropilin 1	Mus musculus	51-63
26731579-6	2016	We show that 3-O-sulfation enhanced the binding of neuropilin-1 to heparan sulfate immobilized on plastic plates and to heparan sulfate present on cultured cells.	Heparitin Sulfate	120-135	neuropilin 1	Mus musculus	51-63
26731579-7	2016	Chemoenzymatically synthesized 3-O-sulfated heparan sulfate dodecamers protected neuropilin-1 from thermal denaturation and inhibited neuropilin-1-dependent, semaphorin-3a-induced growth cone collapse of neurons derived from murine dorsal root ganglia.	Heparitin Sulfate	44-59	neuropilin 1	Mus musculus	81-93
26731579-7	2016	Chemoenzymatically synthesized 3-O-sulfated heparan sulfate dodecamers protected neuropilin-1 from thermal denaturation and inhibited neuropilin-1-dependent, semaphorin-3a-induced growth cone collapse of neurons derived from murine dorsal root ganglia.	Heparitin Sulfate	44-59	neuropilin 1	Mus musculus	134-146
26873445-1	2016	Heparanase, a heparan sulfate (HS)--specific endoglucuronidase, mediates the onset of proteinuria and renal damage during experimental diabetic nephropathy.	Heparitin Sulfate	14-29	heparanase	Mus musculus	0-10
26873445-1	2016	Heparanase, a heparan sulfate (HS)--specific endoglucuronidase, mediates the onset of proteinuria and renal damage during experimental diabetic nephropathy.	Heparitin Sulfate	31-33	heparanase	Mus musculus	0-10
26889021-2	2016	A27 is one of the three glycosaminoglycan (GAG) adhesion molecules and binds to heparan sulfate.	Heparitin Sulfate	80-95	immunoglobulin kappa variable 3-20	Homo sapiens	0-3
26889021-13	2016	We identified one protective antibody that binds adjacent to the heparan sulfate binding site of A27, likely affecting ligand binding.	Heparitin Sulfate	65-80	immunoglobulin kappa variable 3-20	Homo sapiens	97-100
26959705-3	2016	Different genetically modified mouse models have been instrumental to provide evidence that syndecan1, the core protein of HSPG, but also the degree of sulfation of the heparin sulfate chain, attached to syndecan 1, is important for hepatic TRL metabolism.	Heparitin Sulfate	169-184	syndecan 1	Mus musculus	204-214
26559461-2	2016	FGF10 specifically activates FGFR2b in a paracrine manner with heparan sulfate as a co-factor.	Heparitin Sulfate	63-78	fibroblast growth factor 10	Mus musculus	0-5
26852939-2	2016	We here demonstrate that binding of the chemokine-like inflammatory cytokine macrophage migration inhibitory factor (MIF) to epithelial lung and breast tumor cell lines A549 and MDA-MB231 is sensitive to enzymatic digestion of heparan sulphate chains and competitive inhibition with heparin.	Heparitin Sulfate	227-243	macrophage migration inhibitory factor	Homo sapiens	77-115
26852939-2	2016	We here demonstrate that binding of the chemokine-like inflammatory cytokine macrophage migration inhibitory factor (MIF) to epithelial lung and breast tumor cell lines A549 and MDA-MB231 is sensitive to enzymatic digestion of heparan sulphate chains and competitive inhibition with heparin.	Heparitin Sulfate	227-243	macrophage migration inhibitory factor	Homo sapiens	117-120
26852939-4	2016	These results suggested that proteoglycans carrying heparan sulphate chains are involved in MIF binding.	Heparitin Sulfate	52-68	macrophage migration inhibitory factor	Homo sapiens	92-95
27030596-5	2016	We show that removal of neuronal HS by conditional deletion of the Ext1 gene, which encodes an essential glycosyltransferase for HS biosynthesis, in postnatal neurons of amyloid model APP/PS1 mice led to a reduction in both Abeta oligomerization and the deposition of amyloid plaques.	Heparitin Sulfate	33-35	exostosin glycosyltransferase 1	Mus musculus	67-71
27161709-4	2016	HPA is an endo-beta-D-glucuronidase, capable of cleaving the lateral chains of heparan sulfate on cell surfaces and the extracellular matrix at acidic pH.	Heparitin Sulfate	79-94	glucuronidase beta	Homo sapiens	15-35
26626972-9	2016	Sulphamidase infusion mediated a statistically significant reduction in primary (heparan sulphate) and secondary (gangliosides GM2, GM3) substrate accumulation in the brain, with small reductions in micro- but not astro-gliosis.	Heparitin Sulfate	81-97	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	0-12
26997434-1	2016	The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively.	Heparitin Sulfate	170-185	chondroitin sulfate synthase 1	Homo sapiens	25-55
26997434-1	2016	The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively.	Heparitin Sulfate	170-185	chondroitin sulfate synthase 1	Homo sapiens	57-62
26997434-1	2016	The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively.	Heparitin Sulfate	170-185	exostosin like glycosyltransferase 3	Homo sapiens	68-84
26997434-1	2016	The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively.	Heparitin Sulfate	170-185	exostosin like glycosyltransferase 3	Homo sapiens	86-91
27067977-1	2016	Heparanase is an endo-beta-D-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix.	Heparitin Sulfate	71-86	glucuronidase beta	Homo sapiens	22-42
27030596-0	2016	Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-beta clearance and aggregation in Alzheimer"s disease.	Heparitin Sulfate	9-25	amyloid beta precursor protein	Homo sapiens	72-84
27030596-4	2016	Cell surface heparan sulfates (HSs), expressed on all cell types including neurons, have been implicated in several features in the pathogenesis of AD including its colocalization with amyloid plaques and modulatory role in Abeta aggregation.	Heparitin Sulfate	13-29	amyloid beta precursor protein	Homo sapiens	224-229
27030596-5	2016	We show that removal of neuronal HS by conditional deletion of the Ext1 gene, which encodes an essential glycosyltransferase for HS biosynthesis, in postnatal neurons of amyloid model APP/PS1 mice led to a reduction in both Abeta oligomerization and the deposition of amyloid plaques.	Heparitin Sulfate	33-35	presenilin 1	Mus musculus	188-191
27030596-5	2016	We show that removal of neuronal HS by conditional deletion of the Ext1 gene, which encodes an essential glycosyltransferase for HS biosynthesis, in postnatal neurons of amyloid model APP/PS1 mice led to a reduction in both Abeta oligomerization and the deposition of amyloid plaques.	Heparitin Sulfate	33-35	amyloid beta (A4) precursor protein	Mus musculus	224-229
26764203-0	2016	Heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, regulate glomerular integrity by modulating growth factor signaling.	Heparitin Sulfate	0-15	sulfatase 1	Mus musculus	36-41
26987116-2	2016	In Drosophila, Sdc binds via its extracellular heparan sulfate (HS) sidechains to the receptor protein tyrosine phosphatase LAR to promote the morphological growth of the neuromuscular junction (NMJ).	Heparitin Sulfate	47-62	Syndecan	Drosophila melanogaster	15-18
26987116-2	2016	In Drosophila, Sdc binds via its extracellular heparan sulfate (HS) sidechains to the receptor protein tyrosine phosphatase LAR to promote the morphological growth of the neuromuscular junction (NMJ).	Heparitin Sulfate	64-66	Syndecan	Drosophila melanogaster	15-18
26987116-2	2016	In Drosophila, Sdc binds via its extracellular heparan sulfate (HS) sidechains to the receptor protein tyrosine phosphatase LAR to promote the morphological growth of the neuromuscular junction (NMJ).	Heparitin Sulfate	64-66	Leukocyte-antigen-related-like	Drosophila melanogaster	124-127
26764203-0	2016	Heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, regulate glomerular integrity by modulating growth factor signaling.	Heparitin Sulfate	0-15	sulfatase 2	Mus musculus	46-51
27192836-7	2016	The results obtained demonstrate that two isoforms of membrane-bound Hsp90 are involved in migration of tumor cells in vitro and that cell surface heparan sulfate proteoglycans play a pivotal role in the "anchoring" of Hsp90alpha and Hsp90beta to the plasma membrane.	Heparitin Sulfate	147-162	heat shock protein 90 alpha family class A member 1	Homo sapiens	219-229
27192836-7	2016	The results obtained demonstrate that two isoforms of membrane-bound Hsp90 are involved in migration of tumor cells in vitro and that cell surface heparan sulfate proteoglycans play a pivotal role in the "anchoring" of Hsp90alpha and Hsp90beta to the plasma membrane.	Heparitin Sulfate	147-162	heat shock protein 90 alpha family class B member 1	Homo sapiens	234-243
26708018-1	2016	In previous studies Sulf2 has been evidenced to play an important role in tumor progression through editing sulfate moieties on heparan sulfate proteoglycans (HSPGs) and modulating heparin binding growth factors.	Heparitin Sulfate	128-143	sulfatase 2	Homo sapiens	20-25
26733159-1	2016	Sulfatase 2 (SULF2) is an extracellular enzyme that catalyzes the removal of 6-O-sulfate groups from the heparan sulfate (HS).	Heparitin Sulfate	105-120	sulfatase 2	Homo sapiens	0-11
26733159-1	2016	Sulfatase 2 (SULF2) is an extracellular enzyme that catalyzes the removal of 6-O-sulfate groups from the heparan sulfate (HS).	Heparitin Sulfate	105-120	sulfatase 2	Homo sapiens	13-18
26733159-1	2016	Sulfatase 2 (SULF2) is an extracellular enzyme that catalyzes the removal of 6-O-sulfate groups from the heparan sulfate (HS).	Heparitin Sulfate	122-124	sulfatase 2	Homo sapiens	0-11
26733159-1	2016	Sulfatase 2 (SULF2) is an extracellular enzyme that catalyzes the removal of 6-O-sulfate groups from the heparan sulfate (HS).	Heparitin Sulfate	122-124	sulfatase 2	Homo sapiens	13-18
26226327-0	2016	Acute Exacerbations of COPD Are Associated With Increased Expression of Heparan Sulfate and Chondroitin Sulfate in BAL.	Heparitin Sulfate	72-87	poly(ADP-ribose) polymerase family member 9	Homo sapiens	115-118
26226327-6	2016	RESULTS: Heparan sulfate and chondroitin sulfate were significantly increased in BAL of patients during exacerbations.	Heparitin Sulfate	9-24	poly(ADP-ribose) polymerase family member 9	Homo sapiens	81-84
26226327-7	2016	Levels of heparan sulfate were higher in the BAL of patients with microbial infections.	Heparitin Sulfate	10-25	poly(ADP-ribose) polymerase family member 9	Homo sapiens	45-48
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Heparitin Sulfate	13-28	matrix metallopeptidase 9	Homo sapiens	88-93
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Heparitin Sulfate	13-28	matrix metallopeptidase 2	Homo sapiens	95-100
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Heparitin Sulfate	13-28	matrix metallopeptidase 12	Homo sapiens	106-112
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Heparitin Sulfate	13-28	poly(ADP-ribose) polymerase family member 9	Homo sapiens	116-119
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Heparitin Sulfate	13-28	matrix metallopeptidase 2	Homo sapiens	194-198
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Heparitin Sulfate	13-28	poly(ADP-ribose) polymerase family member 9	Homo sapiens	230-233
26226327-10	2016	CONCLUSIONS: During AECOPD, there is increased expression of heparan sulfate and chondroitin sulfate in BAL.	Heparitin Sulfate	61-76	poly(ADP-ribose) polymerase family member 9	Homo sapiens	104-107
26250908-9	2016	In particular, desulfation at the 2-O position in the HS chain contributed to the premature senescence via the augmented FGFR1 signaling.	Heparitin Sulfate	54-56	fibroblast growth factor receptor 1	Homo sapiens	121-126
26909794-6	2016	We found that both the ectodomain and heparan sulfate chains of Sdc1 were required for full activity of Sdc1 in regulating ECM alignment, while transmembrane and cytoplasmic domains were dispensable.	Heparitin Sulfate	38-53	syndecan 1	Homo sapiens	64-68
26926788-3	2016	A likely target of the enzyme is the heparan sulfate (HS) proteoglycan syndecan-1 (Sdc1, CD138), which is highly expressed on myeloma cells and contributes to poor prognosis in this disease.	Heparitin Sulfate	37-52	syndecan 1	Homo sapiens	71-81
26926788-3	2016	A likely target of the enzyme is the heparan sulfate (HS) proteoglycan syndecan-1 (Sdc1, CD138), which is highly expressed on myeloma cells and contributes to poor prognosis in this disease.	Heparitin Sulfate	37-52	syndecan 1	Homo sapiens	83-87
26926788-3	2016	A likely target of the enzyme is the heparan sulfate (HS) proteoglycan syndecan-1 (Sdc1, CD138), which is highly expressed on myeloma cells and contributes to poor prognosis in this disease.	Heparitin Sulfate	37-52	syndecan 1	Homo sapiens	89-94
26926788-3	2016	A likely target of the enzyme is the heparan sulfate (HS) proteoglycan syndecan-1 (Sdc1, CD138), which is highly expressed on myeloma cells and contributes to poor prognosis in this disease.	Heparitin Sulfate	54-56	syndecan 1	Homo sapiens	71-81
26926788-3	2016	A likely target of the enzyme is the heparan sulfate (HS) proteoglycan syndecan-1 (Sdc1, CD138), which is highly expressed on myeloma cells and contributes to poor prognosis in this disease.	Heparitin Sulfate	54-56	syndecan 1	Homo sapiens	83-87
26926788-3	2016	A likely target of the enzyme is the heparan sulfate (HS) proteoglycan syndecan-1 (Sdc1, CD138), which is highly expressed on myeloma cells and contributes to poor prognosis in this disease.	Heparitin Sulfate	54-56	syndecan 1	Homo sapiens	89-94
26909794-6	2016	We found that both the ectodomain and heparan sulfate chains of Sdc1 were required for full activity of Sdc1 in regulating ECM alignment, while transmembrane and cytoplasmic domains were dispensable.	Heparitin Sulfate	38-53	syndecan 1	Homo sapiens	104-108
25420466-10	2016	Taken together, these results suggest that heparan sulfate chains activate FGF-2, which in turn elevates the expression and/or activity of metal transporter(s) that facilitate cadmium influx from the extracellular space into the cytoplasm.	Heparitin Sulfate	43-58	fibroblast growth factor 2	Bos taurus	75-80
26870616-4	2016	Our results revealed that the wound healing induced by CXCL8 was greatly attenuated by removal of HS.	Heparitin Sulfate	98-100	C-X-C motif chemokine ligand 8	Homo sapiens	55-60
26807595-2	2016	In this study, the effects of milk components (calcium, lactose, lipids, and heparan sulfate) and crowding agents on reduced and carboxymethylated (RCM) kappa-casein fibril formation was investigated using far-UV circular dichroism spectroscopy, thioflavin T binding assays, and transmission electron microscopy.	Heparitin Sulfate	77-92	casein kappa	Homo sapiens	153-165
26870616-0	2016	Role of heparan sulfate in mediating CXCL8-induced endothelial cell migration.	Heparitin Sulfate	8-23	C-X-C motif chemokine ligand 8	Homo sapiens	37-42
26870616-7	2016	Taken together, our results demonstrated an essential role of HS in mediating CXCL8-induced endothelial cell migration, and highlighted the biological importance of the interaction between CXCL8 and heparan sulfate in wound healing.	Heparitin Sulfate	62-64	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
24618185-2	2016	This study reports the successful use of synthetic heparan sulphate (Cacipliq20( ) , OTR3, Paris, France) in the treatment of a sickle cell ulcer that had failed to respond to several other means of treatment.	Heparitin Sulfate	51-67	zinc finger protein 746	Homo sapiens	91-96
26870616-7	2016	Taken together, our results demonstrated an essential role of HS in mediating CXCL8-induced endothelial cell migration, and highlighted the biological importance of the interaction between CXCL8 and heparan sulfate in wound healing.	Heparitin Sulfate	199-214	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
26645816-0	2016	The Caenorhabditis elegans Ephrin EFN-4 Functions Non-cell Autonomously with Heparan Sulfate Proteoglycans to Promote Axon Outgrowth and Branching.	Heparitin Sulfate	77-92	Ephrin-4	Caenorhabditis elegans	34-39
26601950-3	2016	Using exosomes isolated from myeloma cell lines and from myeloma patients, we identify exosomal fibronectin as a key heparan sulfate-binding ligand and mediator of exosome-cell interactions.	Heparitin Sulfate	117-132	fibronectin 1	Homo sapiens	96-107
26832929-3	2016	The heparan sulfate proteoglycan, syndecan-1 (CD138), was reported to regulate fibrosis, angiogenesis, inflammation and S. aureus infection.	Heparitin Sulfate	4-19	syndecan 1	Mus musculus	34-44
26601950-5	2016	Removal of heparan sulfate from the exosome surface releases fibronectin and dramatically inhibits exosome-target cell interaction.	Heparitin Sulfate	11-26	fibronectin 1	Homo sapiens	61-72
26601950-4	2016	We discovered that heparan sulfate plays a dual role in exosome-cell interaction; heparan sulfate on exosomes captures fibronectin, and on target cells it acts as a receptor for fibronectin.	Heparitin Sulfate	19-34	fibronectin 1	Homo sapiens	119-130
26601950-10	2016	These studies provide the first evidence that fibronectin binding to heparan sulfate mediates exosome-cell interactions, revealing a fundamental mechanism important for exosome-mediated cross-talk within tumor microenvironments.	Heparitin Sulfate	69-84	fibronectin 1	Homo sapiens	46-57
26601950-11	2016	Moreover, these results imply that therapeutic disruption of fibronectin-heparan sulfate interactions will negatively impact myeloma tumor growth and progression.	Heparitin Sulfate	73-88	fibronectin 1	Homo sapiens	61-72
26601950-4	2016	We discovered that heparan sulfate plays a dual role in exosome-cell interaction; heparan sulfate on exosomes captures fibronectin, and on target cells it acts as a receptor for fibronectin.	Heparitin Sulfate	19-34	fibronectin 1	Homo sapiens	178-189
26713365-6	2016	Similarly, targeted suppression of Ext1 by RNAi significantly suppressed cell surface expression of heparan sulfate and MCP-1 production in colon 26 cells.	Heparitin Sulfate	100-115	exostosin glycosyltransferase 1	Mus musculus	35-39
26601950-4	2016	We discovered that heparan sulfate plays a dual role in exosome-cell interaction; heparan sulfate on exosomes captures fibronectin, and on target cells it acts as a receptor for fibronectin.	Heparitin Sulfate	82-97	fibronectin 1	Homo sapiens	119-130
27579035-1	2016	Syndecan-1 (SDC1), with a long variable ectodomain carrying heparan sulfate chains, participates in many steps of inflammatory responses.	Heparitin Sulfate	60-75	syndecan 1	Homo sapiens	0-10
26729870-1	2016	Heparanase is an endoglycosidase that cleaves heparan sulfate side chains of proteoglycans, resulting in disassembly of the extracellular matrix underlying endothelial and epithelial cells and associating with enhanced cell invasion and metastasis.	Heparitin Sulfate	46-61	heparanase	Homo sapiens	0-10
27119984-2	2016	Syndecan-3 (SDC3), a member of the syndecan family of type I transmembrane heparan sulfate proteoglycans is a novel regulator of feeding behavior and body weight.	Heparitin Sulfate	75-90	syndecan 3	Bos taurus	0-10
27119984-2	2016	Syndecan-3 (SDC3), a member of the syndecan family of type I transmembrane heparan sulfate proteoglycans is a novel regulator of feeding behavior and body weight.	Heparitin Sulfate	75-90	syndecan 3	Bos taurus	12-16
26801396-0	2016	Heparan sulfate proteoglycans mediate Abeta-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells.	Heparitin Sulfate	0-15	amyloid beta precursor protein	Rattus norvegicus	38-43
26801396-3	2016	In this report, we examine the role of heparan sulfate proteoglycans (HSPG) in Abeta-induced vascular smooth muscle cell (VSMC) dysfunction in vitro.	Heparitin Sulfate	39-54	syndecan 1	Rattus norvegicus	70-74
26801396-3	2016	In this report, we examine the role of heparan sulfate proteoglycans (HSPG) in Abeta-induced vascular smooth muscle cell (VSMC) dysfunction in vitro.	Heparitin Sulfate	39-54	amyloid beta precursor protein	Rattus norvegicus	79-84
27579035-1	2016	Syndecan-1 (SDC1), with a long variable ectodomain carrying heparan sulfate chains, participates in many steps of inflammatory responses.	Heparitin Sulfate	60-75	syndecan 1	Homo sapiens	12-16
26387558-4	2016	Heparanase is an endoglycosidase with a role in remodelling the extracellular matrix through its ability to degrade heparan sulphate, and is involved in the pathogenesis of several proteinuric and fibrotic renal diseases.	Heparitin Sulfate	116-132	heparanase	Homo sapiens	0-10
26649979-0	2016	Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation.	Heparitin Sulfate	0-15	toll-like receptor 9	Mus musculus	68-72
26525852-0	2015	Affinity of the heparin binding motif of Noggin1 to heparan sulfate and its visualization in the embryonic tissues.	Heparitin Sulfate	52-67	noggin S homeolog	Xenopus laevis	41-48
26783399-0	2016	Exogenous Heparan Sulfate Enhances the TGF-beta3-Induced Chondrogenesis in Human Mesenchymal Stem Cells by Activating TGF-beta/Smad Signaling.	Heparitin Sulfate	10-25	transforming growth factor beta 3	Homo sapiens	39-48
26783399-0	2016	Exogenous Heparan Sulfate Enhances the TGF-beta3-Induced Chondrogenesis in Human Mesenchymal Stem Cells by Activating TGF-beta/Smad Signaling.	Heparitin Sulfate	10-25	transforming growth factor beta 1	Homo sapiens	39-47
26783399-2	2016	However, the effect of HS on TGF-beta-mediated mesenchymal stem cell (MSC) chondrogenesis and molecular mechanisms remains unknown.	Heparitin Sulfate	23-25	transforming growth factor beta 1	Homo sapiens	29-37
26574650-6	2015	In an attempt to establish structure activity relationships of heparan sulfate binding with its receptor, the synthesized oligosaccharides were incorporated onto a glycan microarray, and their bindings with a growth factor FGF-2 were examined.	Heparitin Sulfate	63-78	fibroblast growth factor 2	Homo sapiens	223-228
27326280-2	2012	Part of a group of clinically progressive disorders, it is caused by the deficiency of the lysosomal enzyme, alpha-L -iduronidase, which results in intralysosomal accumulation of dermatan sulfate and heparan sulfate and in turn causes cell dysfunction.	Heparitin Sulfate	200-215	alpha-L-iduronidase	Homo sapiens	109-129
26116392-0	2016	Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.	Heparitin Sulfate	8-23	glucuronyl C5-epimerase	Mus musculus	37-41
26116392-2	2016	Previous studies have shown that the distribution and signaling activity of Ihh is regulated by the concentration of the extracellular glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	153-168	Indian hedgehog	Mus musculus	76-79
26116392-2	2016	Previous studies have shown that the distribution and signaling activity of Ihh is regulated by the concentration of the extracellular glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	170-172	Indian hedgehog	Mus musculus	76-79
26116392-3	2016	An essential step during biosynthesis of HS is the epimerization of D-glucuronic to L-iduronic acid by the enzyme glucuronyl C5-epimerase (Hsepi or Glce).	Heparitin Sulfate	41-43	glucuronyl C5-epimerase	Mus musculus	114-137
26116392-3	2016	An essential step during biosynthesis of HS is the epimerization of D-glucuronic to L-iduronic acid by the enzyme glucuronyl C5-epimerase (Hsepi or Glce).	Heparitin Sulfate	41-43	glucuronyl C5-epimerase	Mus musculus	139-144
26116392-3	2016	An essential step during biosynthesis of HS is the epimerization of D-glucuronic to L-iduronic acid by the enzyme glucuronyl C5-epimerase (Hsepi or Glce).	Heparitin Sulfate	41-43	glucuronyl C5-epimerase	Mus musculus	148-152
26449522-11	2015	Cardiomyocytes and fibroblasts exposed to shed heparan sulfate-substituted syndecan-4 ectodomains showed increased Icam1, Vcam1, TNFalpha and IL-1beta expression and NF-kappaB-activation, suggesting direct regulation of immune cell recruitment pathways.	Heparitin Sulfate	47-62	syndecan 4	Mus musculus	75-85
26552066-2	2015	By means of its enzymatic activity, HPSE catalyzes the cutting of the side chains of heparan sulfate (HS) proteoglycans, thereby inducing the remodeling of the extracellular matrix and basement membranes.	Heparitin Sulfate	85-100	heparanase	Homo sapiens	36-40
26552066-2	2015	By means of its enzymatic activity, HPSE catalyzes the cutting of the side chains of heparan sulfate (HS) proteoglycans, thereby inducing the remodeling of the extracellular matrix and basement membranes.	Heparitin Sulfate	102-104	heparanase	Homo sapiens	36-40
26552066-4	2015	In addition to degrading HS chains, HPSE has non-enzymatic functions that trigger several signaling pathways.	Heparitin Sulfate	25-27	heparanase	Homo sapiens	36-40
26272754-0	2015	Heparin/heparan sulfates bind to and modulate neuronal L-type (Cav1.2) voltage-dependent Ca(2+) channels.	Heparitin Sulfate	8-24	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	63-69
26272754-2	2015	Here we used isothermal titration calorimetry and screened a set of peptides derived from the extracellular domains of Cav1.2alpha1 to identify putative binding sites between the channel and hyaluronic acid or another class of polyanionic glycans, such as heparin/heparan sulfates.	Heparitin Sulfate	264-280	caveolin 1	Homo sapiens	119-131
26306634-7	2015	The results provide the structural basis for a model of heparin/heparan sulfate binding to TGF-beta1 and demonstrate that the features in the polysaccharide required for binding are not identical to those required for sustaining the signaling by TGF-beta1 in hMSCs.	Heparitin Sulfate	64-79	transforming growth factor beta 1	Homo sapiens	91-100
26318599-1	2015	Heparan sulfate (HS)-containing, S-nitrosylated (SNO) glypican-1 (Gpc-1) releases anhydromannose-containing HS (anMan-HS) by SNO-catalyzed autodegradation in endosomes.	Heparitin Sulfate	0-15	glypican 1	Mus musculus	54-64
26318599-1	2015	Heparan sulfate (HS)-containing, S-nitrosylated (SNO) glypican-1 (Gpc-1) releases anhydromannose-containing HS (anMan-HS) by SNO-catalyzed autodegradation in endosomes.	Heparitin Sulfate	0-15	glypican 1	Mus musculus	66-71
26318599-1	2015	Heparan sulfate (HS)-containing, S-nitrosylated (SNO) glypican-1 (Gpc-1) releases anhydromannose-containing HS (anMan-HS) by SNO-catalyzed autodegradation in endosomes.	Heparitin Sulfate	17-19	glypican 1	Mus musculus	54-64
26318599-1	2015	Heparan sulfate (HS)-containing, S-nitrosylated (SNO) glypican-1 (Gpc-1) releases anhydromannose-containing HS (anMan-HS) by SNO-catalyzed autodegradation in endosomes.	Heparitin Sulfate	17-19	glypican 1	Mus musculus	66-71
26525373-1	2015	Histidine-rich glycoprotein (HRG) is an enigmatic glycoprotein able to interact with a variety of ligands such as IgG, complement components, heparan sulfate, thrombospondin, fibrinogen and plasminogen.	Heparitin Sulfate	142-157	histidine rich glycoprotein	Homo sapiens	0-27
26525373-1	2015	Histidine-rich glycoprotein (HRG) is an enigmatic glycoprotein able to interact with a variety of ligands such as IgG, complement components, heparan sulfate, thrombospondin, fibrinogen and plasminogen.	Heparitin Sulfate	142-157	histidine rich glycoprotein	Homo sapiens	29-32
26575439-2	2015	Breakdown of HS is carried out by heparanase (HPSE), an endo-beta-glucuronidase of the glycoside hydrolase 79 (GH79) family.	Heparitin Sulfate	13-15	heparanase	Homo sapiens	34-44
26575439-2	2015	Breakdown of HS is carried out by heparanase (HPSE), an endo-beta-glucuronidase of the glycoside hydrolase 79 (GH79) family.	Heparitin Sulfate	13-15	heparanase	Homo sapiens	46-50
26575439-2	2015	Breakdown of HS is carried out by heparanase (HPSE), an endo-beta-glucuronidase of the glycoside hydrolase 79 (GH79) family.	Heparitin Sulfate	13-15	glucuronidase beta	Homo sapiens	61-79
26600070-1	2015	Heparanase is an endo-beta-glucuronidase that cleaves heparan sulfate side chains from their proteoglycans.	Heparitin Sulfate	54-69	glucuronidase beta	Homo sapiens	22-40
26416892-6	2015	Hallmarks of unconventional secretion of FGF2 are: (i) sequential molecular interactions with the inner leaflet along with Tec kinase-dependent tyrosine phosphorylation of FGF2, (ii) PI(4,5)P2-dependent oligomerization and membrane pore formation, and (iii) extracellular trapping of FGF2 mediated by heparan sulfate proteoglycans on cell surfaces.	Heparitin Sulfate	301-316	fibroblast growth factor 2	Homo sapiens	41-45
26601141-3	2015	We describe the convergence of an HS-dependent pathway with the C-end rule (CendR) mechanism that enables peptide ligation with neuropilin-1 (NRP1), a cell surface receptor known to be involved in angiogenesis and vascular permeability.	Heparitin Sulfate	34-36	neuropilin 1	Homo sapiens	128-140
26601141-3	2015	We describe the convergence of an HS-dependent pathway with the C-end rule (CendR) mechanism that enables peptide ligation with neuropilin-1 (NRP1), a cell surface receptor known to be involved in angiogenesis and vascular permeability.	Heparitin Sulfate	34-36	neuropilin 1	Homo sapiens	142-146
26449522-11	2015	Cardiomyocytes and fibroblasts exposed to shed heparan sulfate-substituted syndecan-4 ectodomains showed increased Icam1, Vcam1, TNFalpha and IL-1beta expression and NF-kappaB-activation, suggesting direct regulation of immune cell recruitment pathways.	Heparitin Sulfate	47-62	intercellular adhesion molecule 1	Mus musculus	115-120
26449522-11	2015	Cardiomyocytes and fibroblasts exposed to shed heparan sulfate-substituted syndecan-4 ectodomains showed increased Icam1, Vcam1, TNFalpha and IL-1beta expression and NF-kappaB-activation, suggesting direct regulation of immune cell recruitment pathways.	Heparitin Sulfate	47-62	vascular cell adhesion molecule 1	Mus musculus	122-127
26449522-11	2015	Cardiomyocytes and fibroblasts exposed to shed heparan sulfate-substituted syndecan-4 ectodomains showed increased Icam1, Vcam1, TNFalpha and IL-1beta expression and NF-kappaB-activation, suggesting direct regulation of immune cell recruitment pathways.	Heparitin Sulfate	47-62	tumor necrosis factor	Mus musculus	129-137
26449522-11	2015	Cardiomyocytes and fibroblasts exposed to shed heparan sulfate-substituted syndecan-4 ectodomains showed increased Icam1, Vcam1, TNFalpha and IL-1beta expression and NF-kappaB-activation, suggesting direct regulation of immune cell recruitment pathways.	Heparitin Sulfate	47-62	interleukin 1 beta	Mus musculus	142-150
26449522-11	2015	Cardiomyocytes and fibroblasts exposed to shed heparan sulfate-substituted syndecan-4 ectodomains showed increased Icam1, Vcam1, TNFalpha and IL-1beta expression and NF-kappaB-activation, suggesting direct regulation of immune cell recruitment pathways.	Heparitin Sulfate	47-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	166-175
26448642-1	2015	INTRODUCTION: Sulf1 and Sulf2 are cell surface sulfatases, which remove specific 6-O-sulfate groups from heparan sulfate (HS) proteoglycans, resulting in modulation of various HS-dependent signaling pathways.	Heparitin Sulfate	105-120	sulfatase 1	Mus musculus	14-19
26410339-9	2015	CONCLUSIONS: The mRNA expression of HS3ST3A1, which encodes for a 3-O sulfating enzyme of heparan sulfate (3-OST-3A1), is decreased in pre-eclamptic placental tissue.	Heparitin Sulfate	90-105	heparan sulfate-glucosamine 3-sulfotransferase 3A1	Homo sapiens	36-44
26493749-1	2015	Heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase (HGSNAT) catalyzes the transmembrane acetylation of heparan sulfate in lysosomes required for its further catabolism.	Heparitin Sulfate	119-134	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	0-66
26493749-1	2015	Heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase (HGSNAT) catalyzes the transmembrane acetylation of heparan sulfate in lysosomes required for its further catabolism.	Heparitin Sulfate	119-134	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	68-74
26491162-3	2016	To test directly this hypothesis, we created mice that lack Ext1, an enzyme required for heparan sulfate biosynthesis, in hepatocytes.	Heparitin Sulfate	89-104	exostosin glycosyltransferase 1	Mus musculus	60-64
26491162-4	2016	Ext1(HEP) mutant mice exhibit an 8-fold reduction of heparan sulfate in primary hepatocytes and a 5-fold reduction of heparan sulfate in whole liver tissue.	Heparitin Sulfate	53-68	exostosin glycosyltransferase 1	Mus musculus	0-4
26491162-4	2016	Ext1(HEP) mutant mice exhibit an 8-fold reduction of heparan sulfate in primary hepatocytes and a 5-fold reduction of heparan sulfate in whole liver tissue.	Heparitin Sulfate	118-133	exostosin glycosyltransferase 1	Mus musculus	0-4
26448642-1	2015	INTRODUCTION: Sulf1 and Sulf2 are cell surface sulfatases, which remove specific 6-O-sulfate groups from heparan sulfate (HS) proteoglycans, resulting in modulation of various HS-dependent signaling pathways.	Heparitin Sulfate	105-120	sulfatase 2	Mus musculus	24-29
26448642-1	2015	INTRODUCTION: Sulf1 and Sulf2 are cell surface sulfatases, which remove specific 6-O-sulfate groups from heparan sulfate (HS) proteoglycans, resulting in modulation of various HS-dependent signaling pathways.	Heparitin Sulfate	122-124	sulfatase 1	Mus musculus	14-19
26448642-1	2015	INTRODUCTION: Sulf1 and Sulf2 are cell surface sulfatases, which remove specific 6-O-sulfate groups from heparan sulfate (HS) proteoglycans, resulting in modulation of various HS-dependent signaling pathways.	Heparitin Sulfate	122-124	sulfatase 2	Mus musculus	24-29
25864455-6	2015	Six other OspF-related proteins were capable of binding heparan sulfate, whereas representative OspE-related and Elp proteins lacked this activity.	Heparitin Sulfate	56-71	nuclear receptor subfamily 5 group A member 1	Homo sapiens	113-116
26336134-7	2015	The glycosylation of HRG may play a key competitive role in the interaction between HRG and heparin sulfate for binding bFGF and activating the FGF receptor.	Heparitin Sulfate	92-107	histidine rich glycoprotein	Homo sapiens	21-24
26336134-7	2015	The glycosylation of HRG may play a key competitive role in the interaction between HRG and heparin sulfate for binding bFGF and activating the FGF receptor.	Heparitin Sulfate	92-107	histidine rich glycoprotein	Homo sapiens	84-87
26336134-7	2015	The glycosylation of HRG may play a key competitive role in the interaction between HRG and heparin sulfate for binding bFGF and activating the FGF receptor.	Heparitin Sulfate	92-107	fibroblast growth factor 2	Homo sapiens	120-124
26292220-0	2015	Cellular interaction and cytotoxicity of the iowa mutation of apolipoprotein A-I (ApoA-IIowa) amyloid mediated by sulfate moieties of heparan sulfate.	Heparitin Sulfate	134-149	apolipoprotein A-I	Cricetulus griseus	62-80
25781054-2	2015	Perlecan, a multi-functional, heparan sulfate proteoglycan, shows diverse effects on distinct cell types, suggesting that it is one of the candidates that can augment the regenerative mechanisms in the injured CNS.	Heparitin Sulfate	30-45	heparan sulfate proteoglycan 2	Bos taurus	0-8
26210886-0	2015	Syndecan-1 alters heparan sulfate composition and signaling pathways in malignant mesothelioma.	Heparitin Sulfate	18-33	syndecan 1	Homo sapiens	0-10
26210886-1	2015	Syndecan-1 is a proteoglycan that acts as co-receptor through its heparan sulfate (HS) chains and plays important roles in cancer.	Heparitin Sulfate	66-81	syndecan 1	Homo sapiens	0-10
26210886-1	2015	Syndecan-1 is a proteoglycan that acts as co-receptor through its heparan sulfate (HS) chains and plays important roles in cancer.	Heparitin Sulfate	83-85	syndecan 1	Homo sapiens	0-10
26210886-4	2015	We used malignant mesothelioma, an aggressive tumor with poor prognosis, as a model and demonstrated that syndecan-1 over-expression down-regulates SULF1 and alters the HS biosynthetic machinery.	Heparitin Sulfate	169-171	syndecan 1	Homo sapiens	106-116
26210886-5	2015	Biochemical characterization revealed a 2.7-fold reduction in HS content upon syndecan-1 over-expression, but an overall increase in sulfation.	Heparitin Sulfate	62-64	syndecan 1	Homo sapiens	78-88
25979432-10	2015	ESL heparan sulfate can also bind L-selectin expressed by the neutrophils, which contributes to rolling and arrest.	Heparitin Sulfate	4-19	selectin L	Homo sapiens	34-44
26246518-0	2015	Old gene, new phenotype: mutations in heparan sulfate synthesis enzyme, EXT2 leads to seizure and developmental disorder, no exostoses.	Heparitin Sulfate	38-53	exostosin glycosyltransferase 2	Homo sapiens	72-76
26203194-5	2015	The C terminus is shown to be highly flexible in solution, but it orients the core protein transverse to the membrane, directing a surface evolutionarily conserved in Gpc1 orthologs toward the membrane, where it may interact with signaling molecules and/or membrane receptors on the cell surface, or even the enzymes involved in heparan sulfate substitution in the Golgi apparatus.	Heparitin Sulfate	329-344	glypican 1	Homo sapiens	167-171
26246518-7	2015	RESULTS: We identified two homozygous mutations p.Met87Arg and p.Arg95 Cys in exostosin 2, EXT2, a ubiquitously expressed gene that encodes a glycosyltransferase required for heparan sulfate synthesis.	Heparitin Sulfate	175-190	exostosin glycosyltransferase 2	Homo sapiens	78-89
26246518-7	2015	RESULTS: We identified two homozygous mutations p.Met87Arg and p.Arg95 Cys in exostosin 2, EXT2, a ubiquitously expressed gene that encodes a glycosyltransferase required for heparan sulfate synthesis.	Heparitin Sulfate	175-190	exostosin glycosyltransferase 2	Homo sapiens	91-95
25940317-6	2015	Moreover, recombinant DcR3.Fc and heparan sulfate proteoglycan binding domain of DcR3.Fc (HBD.Fc) fusion proteins attenuated weight loss and protected mice from IAV-induced lethality.	Heparitin Sulfate	34-49	Dcr3	Mus musculus	81-85
26407983-1	2015	BACKGROUND: Mucopolysaccharidosis type I (MPS I) is caused by the deficiency of alpha-L-iduronidase (IDUA), which is involved in the degradation of glycosaminoglycans (GAGs), such as heparan sulfate and dermatan sulfate in the lysosome.	Heparitin Sulfate	183-198	iduronidase, alpha-L	Mus musculus	101-105
26203194-2	2015	Glypican-1 (Gpc1) is the predominant heparan sulfate proteoglycan in the developing and adult human brain.	Heparitin Sulfate	37-52	glypican 1	Homo sapiens	0-10
25715761-8	2015	Selective expression of heparan sulfate (HS) proteoglycans syndecan-1 and perlecan in the AG2 colon cancer-initiating cell line suggests these PGs as potential biomarkers for cancer stem cells.	Heparitin Sulfate	24-39	syndecan 1	Homo sapiens	59-69
26203194-2	2015	Glypican-1 (Gpc1) is the predominant heparan sulfate proteoglycan in the developing and adult human brain.	Heparitin Sulfate	37-52	glypican 1	Homo sapiens	12-16
26332121-0	2015	Human Monoclonal Antibody Targeting the Heparan Sulfate Chains of Glypican-3 Inhibits HGF-Mediated Migration and Motility of Hepatocellular Carcinoma Cells.	Heparitin Sulfate	40-55	glypican 3	Mus musculus	66-76
26332121-0	2015	Human Monoclonal Antibody Targeting the Heparan Sulfate Chains of Glypican-3 Inhibits HGF-Mediated Migration and Motility of Hepatocellular Carcinoma Cells.	Heparitin Sulfate	40-55	hepatocyte growth factor	Mus musculus	86-89
26332121-13	2015	GPC3 interacted with HGF; however, a mutant GPC3 lacking the HS chain showed less interaction with HGF.	Heparitin Sulfate	61-63	glypican 3	Mus musculus	0-4
26332121-13	2015	GPC3 interacted with HGF; however, a mutant GPC3 lacking the HS chain showed less interaction with HGF.	Heparitin Sulfate	61-63	glypican 3	Mus musculus	44-48
26332121-13	2015	GPC3 interacted with HGF; however, a mutant GPC3 lacking the HS chain showed less interaction with HGF.	Heparitin Sulfate	61-63	hepatocyte growth factor	Mus musculus	99-102
25715761-8	2015	Selective expression of heparan sulfate (HS) proteoglycans syndecan-1 and perlecan in the AG2 colon cancer-initiating cell line suggests these PGs as potential biomarkers for cancer stem cells.	Heparitin Sulfate	24-39	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	90-93
25715761-8	2015	Selective expression of heparan sulfate (HS) proteoglycans syndecan-1 and perlecan in the AG2 colon cancer-initiating cell line suggests these PGs as potential biomarkers for cancer stem cells.	Heparitin Sulfate	41-43	syndecan 1	Homo sapiens	59-69
25715761-8	2015	Selective expression of heparan sulfate (HS) proteoglycans syndecan-1 and perlecan in the AG2 colon cancer-initiating cell line suggests these PGs as potential biomarkers for cancer stem cells.	Heparitin Sulfate	41-43	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	90-93
25483839-1	2015	While antithrombin (AT) has small basal inhibitory activity, it reaches its full inhibitory potential against activated blood coagulation factors, FXa, FIXa, and FIIa (thrombin), via an allosteric and/or template (bridging) mechanism by the action of heparin, heparan sulfate, or heparin-mimetic pentasaccharides (PS).	Heparitin Sulfate	260-275	serpin family C member 1	Homo sapiens	6-18
25977076-9	2015	Myeloperoxidase-positive cells infiltrated infected corneal facsimiles in a sub-Matrigel location, possibly due to CXCL8 colocalization with heparan sulfate, a Matrigel constituent.	Heparitin Sulfate	141-156	myeloperoxidase	Homo sapiens	0-15
26033936-2	2015	In eukaryotic cells, heparan sulfate (HS) is initially degraded by an endo-beta-glucuronidase called heparanase-1 (HPSE).	Heparitin Sulfate	21-36	heparanase	Cricetulus griseus	101-113
26033936-2	2015	In eukaryotic cells, heparan sulfate (HS) is initially degraded by an endo-beta-glucuronidase called heparanase-1 (HPSE).	Heparitin Sulfate	21-36	heparanase	Cricetulus griseus	115-119
26033936-2	2015	In eukaryotic cells, heparan sulfate (HS) is initially degraded by an endo-beta-glucuronidase called heparanase-1 (HPSE).	Heparitin Sulfate	38-40	heparanase	Cricetulus griseus	101-113
26033936-2	2015	In eukaryotic cells, heparan sulfate (HS) is initially degraded by an endo-beta-glucuronidase called heparanase-1 (HPSE).	Heparitin Sulfate	38-40	heparanase	Cricetulus griseus	115-119
25483839-1	2015	While antithrombin (AT) has small basal inhibitory activity, it reaches its full inhibitory potential against activated blood coagulation factors, FXa, FIXa, and FIIa (thrombin), via an allosteric and/or template (bridging) mechanism by the action of heparin, heparan sulfate, or heparin-mimetic pentasaccharides (PS).	Heparitin Sulfate	260-275	coagulation factor II, thrombin	Homo sapiens	10-18
26168721-1	2015	Cellular heparan sulfate (HS) has a dual role in scrapie pathogenesis; it is required for PrP(Sc) (scrapie prion protein) formation and facilitates infection of cells, mediating cellular uptake of prions.	Heparitin Sulfate	9-24	prion protein	Homo sapiens	90-93
25753925-8	2015	Myeloid precursor cells secreted all the APRIL they produced, and binding of secreted APRIL to MM cells, strictly dependent of heparan sulfate carried by CD138, resulted in an in situ internalization by tumor cells.	Heparitin Sulfate	127-142	TNF superfamily member 13	Homo sapiens	86-91
26295701-0	2015	Heparan Sulfate Biosynthesis Enzyme, Ext1, Contributes to Outflow Tract Development of Mouse Heart via Modulation of FGF Signaling.	Heparitin Sulfate	0-15	exostosin glycosyltransferase 1	Mus musculus	37-41
26126828-6	2015	Antibody-independent Tau uptake into BV2 cells was blocked by heparin, consistent with a previously described role for heparan sulfate proteoglycans.	Heparitin Sulfate	119-134	microtubule associated protein tau	Homo sapiens	21-24
26295701-3	2015	Ext1 is a glycosyltransferase responsible for heparan sulfate synthesis.	Heparitin Sulfate	46-61	exostosin glycosyltransferase 1	Mus musculus	0-4
26256079-3	2015	This review summarized the recent studies of oncofetal glypican-3 (GPC-3), a membrane-associated heparan sulfate proteoglycan, in the diagnosis and treatment of HCC.	Heparitin Sulfate	97-112	glypican 3	Homo sapiens	55-65
26251446-3	2015	Gremlin binds strongly to heparin and heparan sulfate and, in the present study, we sought to investigate its heparin-binding site.	Heparitin Sulfate	38-53	gremlin 1, DAN family BMP antagonist	Homo sapiens	0-7
26256047-2	2015	The stability and activity of inflammatory effectors, IL8 and neutrophil elastase (NE), can be prolonged by binding to airway heparan sulfate (HS)/syndecan-1, posing risk for developing chronic obstructive pulmonary disease(COPD).	Heparitin Sulfate	143-145	elastase, neutrophil expressed	Rattus norvegicus	83-85
26256047-2	2015	The stability and activity of inflammatory effectors, IL8 and neutrophil elastase (NE), can be prolonged by binding to airway heparan sulfate (HS)/syndecan-1, posing risk for developing chronic obstructive pulmonary disease(COPD).	Heparitin Sulfate	143-145	syndecan 1	Rattus norvegicus	147-157
26272378-0	2015	The transmembrane heparan sulphate proteoglycan syndecan-4 is involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc.	Heparitin Sulfate	18-34	syndecan 4	Rattus norvegicus	48-58
26265132-8	2015	Gene ontology analysis placed the miRNA-regulated genes (eva1a, layna, nefmb, ina, si:ch211-51a6.2, smoc1, sb:cb252) in key biological processes that included cell survival/apoptosis, ECM-cytoskeleton signaling, and heparan sulfate proteoglycan binding, CONCLUSION: Our results suggest a key role for miR-29b and miR-223 in zebrafish regeneration.	Heparitin Sulfate	216-231	eva-1 homolog A (C. elegans)	Danio rerio	57-62
26256047-2	2015	The stability and activity of inflammatory effectors, IL8 and neutrophil elastase (NE), can be prolonged by binding to airway heparan sulfate (HS)/syndecan-1, posing risk for developing chronic obstructive pulmonary disease(COPD).	Heparitin Sulfate	126-141	elastase, neutrophil expressed	Rattus norvegicus	62-81
26256047-2	2015	The stability and activity of inflammatory effectors, IL8 and neutrophil elastase (NE), can be prolonged by binding to airway heparan sulfate (HS)/syndecan-1, posing risk for developing chronic obstructive pulmonary disease(COPD).	Heparitin Sulfate	126-141	elastase, neutrophil expressed	Rattus norvegicus	83-85
26256047-2	2015	The stability and activity of inflammatory effectors, IL8 and neutrophil elastase (NE), can be prolonged by binding to airway heparan sulfate (HS)/syndecan-1, posing risk for developing chronic obstructive pulmonary disease(COPD).	Heparitin Sulfate	126-141	syndecan 1	Rattus norvegicus	147-157
26256047-2	2015	The stability and activity of inflammatory effectors, IL8 and neutrophil elastase (NE), can be prolonged by binding to airway heparan sulfate (HS)/syndecan-1, posing risk for developing chronic obstructive pulmonary disease(COPD).	Heparitin Sulfate	143-145	elastase, neutrophil expressed	Rattus norvegicus	62-81
26256079-3	2015	This review summarized the recent studies of oncofetal glypican-3 (GPC-3), a membrane-associated heparan sulfate proteoglycan, in the diagnosis and treatment of HCC.	Heparitin Sulfate	97-112	glypican 3	Homo sapiens	67-72
26175493-7	2015	Decreased phosphorylation of VEGFR2 at Tyr(951) was due to ECM-localized TG2, which reduced the binding of VEGF165 to endothelial ECM in a manner that required its ability to bind to HS but not its catalytic activity.	Heparitin Sulfate	183-185	kinase insert domain protein receptor	Mus musculus	29-35
25735873-4	2015	Here we sought to understand how heparanase, the sole mammalian heparan sulfate-degrading endoglycosidase may regulate mammary gland development.	Heparitin Sulfate	64-79	heparanase	Homo sapiens	33-43
26201468-3	2015	Here as a proof-of-concept study, we developed a FGFR1 neutralizing antisera, IMB-R1, employing a novel strategy aimed at preventing the access of essential heparan sulfate (HS) co-receptors to the heparin-binding domain on FGFR1.	Heparitin Sulfate	157-172	fibroblast growth factor receptor 1	Homo sapiens	49-54
26201468-15	2015	CONCLUSION: Our study suggests that blocking HS interaction with the heparin-binding domains of FGFR1 inhibited cancer cell growth, which can be an attractive strategy to inactivate cancer-related heparin-binding proteins.	Heparitin Sulfate	45-47	fibroblast growth factor receptor 1	Homo sapiens	96-101
26175493-7	2015	Decreased phosphorylation of VEGFR2 at Tyr(951) was due to ECM-localized TG2, which reduced the binding of VEGF165 to endothelial ECM in a manner that required its ability to bind to HS but not its catalytic activity.	Heparitin Sulfate	183-185	transglutaminase 2, C polypeptide	Mus musculus	73-76
26079194-10	2015	However, FGF-2 was still captured by fractones via heparan sulfates.	Heparitin Sulfate	51-67	fibroblast growth factor 2	Homo sapiens	9-14
25919894-1	2015	ZG16p is a soluble mammalian lectin that interacts with mannose and heparan sulfate.	Heparitin Sulfate	68-83	zymogen granule protein 16	Homo sapiens	0-5
26148345-3	2015	Here we demonstrate that in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan, modulates UNC-6/netrin signaling and may do this through interactions with the UNC-40/DCC receptor.	Heparitin Sulfate	70-85	LONg	Caenorhabditis elegans	52-57
26148345-3	2015	Here we demonstrate that in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan, modulates UNC-6/netrin signaling and may do this through interactions with the UNC-40/DCC receptor.	Heparitin Sulfate	70-85	GlyPicaN	Caenorhabditis elegans	58-66
26148345-3	2015	Here we demonstrate that in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan, modulates UNC-6/netrin signaling and may do this through interactions with the UNC-40/DCC receptor.	Heparitin Sulfate	70-85	Netrin unc-6	Caenorhabditis elegans	110-115
26148345-3	2015	Here we demonstrate that in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan, modulates UNC-6/netrin signaling and may do this through interactions with the UNC-40/DCC receptor.	Heparitin Sulfate	70-85	Netrin receptor unc-40	Caenorhabditis elegans	179-185
26147524-1	2015	Mucopolysaccharidosis (MPS) IIIB is a lysosomal disease due to the deficiency of the enzyme alpha-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation.	Heparitin Sulfate	143-158	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	92-121
26147524-1	2015	Mucopolysaccharidosis (MPS) IIIB is a lysosomal disease due to the deficiency of the enzyme alpha-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation.	Heparitin Sulfate	143-158	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	123-128
26147524-1	2015	Mucopolysaccharidosis (MPS) IIIB is a lysosomal disease due to the deficiency of the enzyme alpha-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation.	Heparitin Sulfate	160-162	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	92-121
26147524-1	2015	Mucopolysaccharidosis (MPS) IIIB is a lysosomal disease due to the deficiency of the enzyme alpha-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation.	Heparitin Sulfate	160-162	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	123-128
25736604-3	2015	Besides, recently, well-documented association of SAA with high-density lipoprotein or glycosaminoglycans, in particular heparin/heparin sulfate (HS), and specific interaction between SAA and human cystatin C (hCC), the ubiquitous inhibitor of cysteine proteases, was proved.	Heparitin Sulfate	129-144	serum amyloid A1 cluster	Homo sapiens	50-53
25736604-3	2015	Besides, recently, well-documented association of SAA with high-density lipoprotein or glycosaminoglycans, in particular heparin/heparin sulfate (HS), and specific interaction between SAA and human cystatin C (hCC), the ubiquitous inhibitor of cysteine proteases, was proved.	Heparitin Sulfate	129-144	cystatin C	Homo sapiens	198-208
26075383-0	2015	2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.	Heparitin Sulfate	4-19	hemoglobin, activating region	Mus musculus	33-36
26181364-7	2015	These data reveal a heparan sulfate-independent direct binding of CD44v6 to the ligands of Met and VEGFR-2 and suggest different roles of CD44v6 for these RTKs.	Heparitin Sulfate	20-35	kinase insert domain receptor	Homo sapiens	99-106
25931123-0	2015	2-O-Sulfated Domains in Syndecan-1 Heparan Sulfate Inhibit Neutrophil Cathelicidin and Promote Staphylococcus aureus Corneal Infection.	Heparitin Sulfate	35-50	syndecan 1	Mus musculus	24-34
26543570-8	2015	PhRICS was then used to probe the diffusion speed of gold nanoparticle-labelled fibroblast growth factor 2 (FGF2) bound to heparan sulfate in the pericellular matrix of live fibroblast cells.	Heparitin Sulfate	123-138	fibroblast growth factor 2	Homo sapiens	80-106
26543570-8	2015	PhRICS was then used to probe the diffusion speed of gold nanoparticle-labelled fibroblast growth factor 2 (FGF2) bound to heparan sulfate in the pericellular matrix of live fibroblast cells.	Heparitin Sulfate	123-138	fibroblast growth factor 2	Homo sapiens	108-112
25967551-4	2015	Heparan sulfate specifically modifies Shh processing at the cell surface, and purified glycosaminoglycans enhance the proteolytic removal of N- and C-terminal Shh peptides under cell-free conditions.	Heparitin Sulfate	0-15	sonic hedgehog signaling molecule	Homo sapiens	38-41
25967551-5	2015	The most likely explanation for these observations is direct Shh processing in the extracellular compartment, suggesting that heparan sulfate acts as a scaffold or activator for Shh ligands and the factors required for their turnover.	Heparitin Sulfate	126-141	sonic hedgehog signaling molecule	Homo sapiens	61-64
25967551-5	2015	The most likely explanation for these observations is direct Shh processing in the extracellular compartment, suggesting that heparan sulfate acts as a scaffold or activator for Shh ligands and the factors required for their turnover.	Heparitin Sulfate	126-141	sonic hedgehog signaling molecule	Homo sapiens	178-181
25967551-6	2015	We also show that purified heparan sulfate isolated from specific cell types and tissues mediates the release of bioactive Shh from pancreatic cancer cells, revealing a previously unknown regulatory role for these versatile molecules in a pathological context.	Heparitin Sulfate	27-42	sonic hedgehog signaling molecule	Homo sapiens	123-126
26075383-0	2015	2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.	Heparitin Sulfate	4-19	mitogen-activated protein kinase 1	Mus musculus	55-58
25922077-3	2015	Heparan sulfate (HS) side chains bind to IAPP, inducing conformational changes of the IAPP structure and an acceleration of fibril formation.	Heparitin Sulfate	0-15	islet amyloid polypeptide	Cricetulus griseus	41-45
25922077-3	2015	Heparan sulfate (HS) side chains bind to IAPP, inducing conformational changes of the IAPP structure and an acceleration of fibril formation.	Heparitin Sulfate	0-15	islet amyloid polypeptide	Cricetulus griseus	86-90
26075383-5	2015	Loss of Hs2st function phenocopies the thinned cerebral cortex of mutant mice in which Fgf2 or Erk1/2 function are abrogated, suggesting the hypothesis that 2-O-sulfated HS structures play a specific role in Fgf2/Erk signaling pathway in this context in vivo.	Heparitin Sulfate	170-172	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	8-13
25922077-3	2015	Heparan sulfate (HS) side chains bind to IAPP, inducing conformational changes of the IAPP structure and an acceleration of fibril formation.	Heparitin Sulfate	17-19	islet amyloid polypeptide	Cricetulus griseus	41-45
25922077-3	2015	Heparan sulfate (HS) side chains bind to IAPP, inducing conformational changes of the IAPP structure and an acceleration of fibril formation.	Heparitin Sulfate	17-19	islet amyloid polypeptide	Cricetulus griseus	86-90
26040666-2	2015	In this context, a promising candidate could be heparanase-1 (HPSE), an endoglycosidase that cleaves heparan sulfate chains and thus takes part in extracellular matrix remodeling.	Heparitin Sulfate	101-116	heparanase	Homo sapiens	48-60
25922077-11	2015	The interaction between HS and IAPP or the subsequent effects represent a possible therapeutic target whose blockage can lead to a prolonged survival of beta cells.	Heparitin Sulfate	24-26	islet amyloid polypeptide	Cricetulus griseus	31-35
26040666-2	2015	In this context, a promising candidate could be heparanase-1 (HPSE), an endoglycosidase that cleaves heparan sulfate chains and thus takes part in extracellular matrix remodeling.	Heparitin Sulfate	101-116	heparanase	Homo sapiens	62-66
26022293-5	2015	A screen for new Q descendant AQR and PQR migration mutations identified mig-13 as well as hse-5, the gene encoding the glucuronyl C5-epimerase enzyme, which catalyzes epimerization of glucuronic acid to iduronic acid in the heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	225-240	Abnormal cell migration protein 13	Caenorhabditis elegans	73-79
25912421-6	2015	Here, we demonstrate that ARPCA binds FGF8b and inhibits its capacity to form FGFR1-mediated ternary complexes with heparan sulphate proteoglycans.	Heparitin Sulfate	116-132	fibroblast growth factor receptor 1	Mus musculus	78-83
25921251-0	2015	High-resolution probing heparan sulfate-antithrombin interaction on a single endothelial cell surface: single-molecule AFM studies.	Heparitin Sulfate	24-39	serpin family C member 1	Homo sapiens	40-52
25921251-1	2015	Heparan sulfate (HS) plays diverse functions in multiple biological processes by interacting with a wide range of important protein ligands, such as the key anticoagulant factor, antithrombin (AT).	Heparitin Sulfate	0-15	serpin family C member 1	Homo sapiens	179-191
25921251-1	2015	Heparan sulfate (HS) plays diverse functions in multiple biological processes by interacting with a wide range of important protein ligands, such as the key anticoagulant factor, antithrombin (AT).	Heparitin Sulfate	0-15	serpin family C member 1	Homo sapiens	193-195
25921251-1	2015	Heparan sulfate (HS) plays diverse functions in multiple biological processes by interacting with a wide range of important protein ligands, such as the key anticoagulant factor, antithrombin (AT).	Heparitin Sulfate	17-19	serpin family C member 1	Homo sapiens	179-191
25921251-1	2015	Heparan sulfate (HS) plays diverse functions in multiple biological processes by interacting with a wide range of important protein ligands, such as the key anticoagulant factor, antithrombin (AT).	Heparitin Sulfate	17-19	serpin family C member 1	Homo sapiens	193-195
25829497-0	2015	Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.	Heparitin Sulfate	147-162	exostosin like glycosyltransferase 2	Homo sapiens	22-27
25829497-0	2015	Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.	Heparitin Sulfate	147-162	exostosin glycosyltransferase 1	Homo sapiens	45-54
25829497-0	2015	Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.	Heparitin Sulfate	147-162	exostosin glycosyltransferase 1	Homo sapiens	22-25
25829497-3	2015	The human exostosin (EXT) family of genes contains five members: the heparan sulfate polymerizing enzymes, EXT1 and EXT2, and three EXT-like genes, EXTL1, EXTL2, and EXTL3.	Heparitin Sulfate	69-84	exostosin glycosyltransferase 1	Homo sapiens	10-19
25829497-3	2015	The human exostosin (EXT) family of genes contains five members: the heparan sulfate polymerizing enzymes, EXT1 and EXT2, and three EXT-like genes, EXTL1, EXTL2, and EXTL3.	Heparitin Sulfate	69-84	exostosin glycosyltransferase 1	Homo sapiens	21-24
25995222-4	2015	RPTPsigma is reciprocally regulated by interactions with chondroitin sulfate or heparan sulfate containing extracellular proteoglycans in a mechanism called the proteoglycan switch.	Heparitin Sulfate	80-95	protein tyrosine phosphatase receptor type S	Homo sapiens	0-9
25995222-6	2015	Incubation of FLS with a proteoglycan-binding RPTPsigma decoy protein inhibited cell invasiveness and attachment to cartilage by disrupting a constitutive interaction between RPTPsigma and the heparan sulfate proteoglycan syndecan-4.	Heparitin Sulfate	193-208	protein tyrosine phosphatase receptor type S	Homo sapiens	46-55
25995222-6	2015	Incubation of FLS with a proteoglycan-binding RPTPsigma decoy protein inhibited cell invasiveness and attachment to cartilage by disrupting a constitutive interaction between RPTPsigma and the heparan sulfate proteoglycan syndecan-4.	Heparitin Sulfate	193-208	protein tyrosine phosphatase receptor type S	Homo sapiens	175-184
25995222-6	2015	Incubation of FLS with a proteoglycan-binding RPTPsigma decoy protein inhibited cell invasiveness and attachment to cartilage by disrupting a constitutive interaction between RPTPsigma and the heparan sulfate proteoglycan syndecan-4.	Heparitin Sulfate	193-208	syndecan 4	Homo sapiens	222-232
25863260-2	2015	Hereditary multiple exostoses patients carry heterozygous mutations in the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2, but studies suggest that EXT haploinsufficiency and ensuing partial HS deficiency are insufficient for exostosis formation.	Heparitin Sulfate	75-90	exostosin glycosyltransferase 1	Homo sapiens	117-121
25863260-2	2015	Hereditary multiple exostoses patients carry heterozygous mutations in the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2, but studies suggest that EXT haploinsufficiency and ensuing partial HS deficiency are insufficient for exostosis formation.	Heparitin Sulfate	75-90	exostosin glycosyltransferase 2	Homo sapiens	125-129
25863260-2	2015	Hereditary multiple exostoses patients carry heterozygous mutations in the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2, but studies suggest that EXT haploinsufficiency and ensuing partial HS deficiency are insufficient for exostosis formation.	Heparitin Sulfate	92-94	exostosin glycosyltransferase 1	Homo sapiens	117-121
25863260-2	2015	Hereditary multiple exostoses patients carry heterozygous mutations in the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2, but studies suggest that EXT haploinsufficiency and ensuing partial HS deficiency are insufficient for exostosis formation.	Heparitin Sulfate	92-94	exostosin glycosyltransferase 2	Homo sapiens	125-129
25808574-1	2015	Heparanase is an endo-beta-D-glucuronidase cleaving heparan sulfate side-chains of heparin sulfate proteoglycans, which is involved in wound healing, inflammation, neovascularization and tumor progression through the degradation and remodeling of the extracellular matrix and the release of sequestered pro-angiogenic factors.	Heparitin Sulfate	52-67	heparanase	Homo sapiens	0-10
25808574-1	2015	Heparanase is an endo-beta-D-glucuronidase cleaving heparan sulfate side-chains of heparin sulfate proteoglycans, which is involved in wound healing, inflammation, neovascularization and tumor progression through the degradation and remodeling of the extracellular matrix and the release of sequestered pro-angiogenic factors.	Heparitin Sulfate	52-67	glucuronidase beta	Homo sapiens	22-42
25851619-2	2015	Hemophilia B prophylaxis targets plasma FIX levels &gt; 1% but neglects extravascular FIX, which colocalizes with antithrombin-heparan sulfate.	Heparitin Sulfate	127-142	serpin family C member 1	Homo sapiens	114-126
25829497-4	2015	EXTL2 has been ascribed activities related to the initiation and termination of heparan sulfate chains.	Heparitin Sulfate	80-95	exostosin like glycosyltransferase 2	Homo sapiens	0-5
25829497-5	2015	Here we further investigated the role of EXTL2 in heparan sulfate chain elongation by gene silencing and overexpression strategies.	Heparitin Sulfate	50-65	exostosin like glycosyltransferase 2	Homo sapiens	41-46
25829497-7	2015	To study in more detail the role of EXTL2 in heparan sulfate chain elongation, we tested the ability of the overexpressed protein to catalyze the in vitro incorporation of N-acetylglucosamine and N-acetylgalactosamine to oligosaccharide acceptors resembling unmodified heparan sulfate and chondroitin sulfate precursor molecules.	Heparitin Sulfate	45-60	exostosin like glycosyltransferase 2	Homo sapiens	36-41
25829497-8	2015	Analysis of the generated products revealed that recombinant EXTL2 showed weak ability to transfer N-acetylgalactosamine to heparan sulfate precursor molecules but also, that EXTL2 exhibited much stronger in vitro N-acetylglucosamine-transferase activity related to elongation of heparan sulfate chains.	Heparitin Sulfate	124-139	exostosin like glycosyltransferase 2	Homo sapiens	61-66
25829497-8	2015	Analysis of the generated products revealed that recombinant EXTL2 showed weak ability to transfer N-acetylgalactosamine to heparan sulfate precursor molecules but also, that EXTL2 exhibited much stronger in vitro N-acetylglucosamine-transferase activity related to elongation of heparan sulfate chains.	Heparitin Sulfate	280-295	exostosin like glycosyltransferase 2	Homo sapiens	61-66
25829497-8	2015	Analysis of the generated products revealed that recombinant EXTL2 showed weak ability to transfer N-acetylgalactosamine to heparan sulfate precursor molecules but also, that EXTL2 exhibited much stronger in vitro N-acetylglucosamine-transferase activity related to elongation of heparan sulfate chains.	Heparitin Sulfate	280-295	exostosin like glycosyltransferase 2	Homo sapiens	175-180
26022293-5	2015	A screen for new Q descendant AQR and PQR migration mutations identified mig-13 as well as hse-5, the gene encoding the glucuronyl C5-epimerase enzyme, which catalyzes epimerization of glucuronic acid to iduronic acid in the heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	225-240	D-glucuronyl C5-epimerase	Caenorhabditis elegans	91-96
26022293-5	2015	A screen for new Q descendant AQR and PQR migration mutations identified mig-13 as well as hse-5, the gene encoding the glucuronyl C5-epimerase enzyme, which catalyzes epimerization of glucuronic acid to iduronic acid in the heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	256-271	Abnormal cell migration protein 13	Caenorhabditis elegans	73-79
26022293-5	2015	A screen for new Q descendant AQR and PQR migration mutations identified mig-13 as well as hse-5, the gene encoding the glucuronyl C5-epimerase enzyme, which catalyzes epimerization of glucuronic acid to iduronic acid in the heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	256-271	D-glucuronyl C5-epimerase	Caenorhabditis elegans	91-96
25842390-1	2015	Heparan sulphate (glucosamine) 3-O-sulphotransferase 2 (HS3ST2, also known as 3OST2) is an enzyme predominantly expressed in neurons wherein it generates rare 3-O-sulphated domains of unknown functions in heparan sulphates.	Heparitin Sulfate	0-16	heparan sulfate-glucosamine 3-sulfotransferase 2	Homo sapiens	56-62
25842390-1	2015	Heparan sulphate (glucosamine) 3-O-sulphotransferase 2 (HS3ST2, also known as 3OST2) is an enzyme predominantly expressed in neurons wherein it generates rare 3-O-sulphated domains of unknown functions in heparan sulphates.	Heparitin Sulfate	0-16	heparan sulfate-glucosamine 3-sulfotransferase 2	Homo sapiens	78-83
25842390-1	2015	Heparan sulphate (glucosamine) 3-O-sulphotransferase 2 (HS3ST2, also known as 3OST2) is an enzyme predominantly expressed in neurons wherein it generates rare 3-O-sulphated domains of unknown functions in heparan sulphates.	Heparitin Sulfate	205-222	heparan sulfate-glucosamine 3-sulfotransferase 2	Homo sapiens	56-62
25842390-1	2015	Heparan sulphate (glucosamine) 3-O-sulphotransferase 2 (HS3ST2, also known as 3OST2) is an enzyme predominantly expressed in neurons wherein it generates rare 3-O-sulphated domains of unknown functions in heparan sulphates.	Heparitin Sulfate	205-222	heparan sulfate-glucosamine 3-sulfotransferase 2	Homo sapiens	78-83
25842390-4	2015	Here, we first measured the transcript levels of all human heparan sulphate sulphotransferases in hippocampus of Alzheimer"s disease (n = 8; 76.8 +- 3.5 years old) and found increased expression of HS3ST2 (P < 0.001) compared with control brain (n = 8; 67.8 +- 2.9 years old).	Heparitin Sulfate	59-75	heparan sulfate-glucosamine 3-sulfotransferase 2	Homo sapiens	198-204
25842390-7	2015	We showed, in vitro, that the 3-O-sulphated heparan sulphates bind to tau, but not to GSK3B, protein kinase A or protein phosphatase 2, inducing its abnormal phosphorylation.	Heparitin Sulfate	44-61	microtubule associated protein tau	Homo sapiens	70-73
25842390-10	2015	By interacting with tau at the intracellular level, the 3-O-sulphated heparan sulphates produced by HS3ST2 might act as molecular chaperones allowing the abnormal phosphorylation of tau.	Heparitin Sulfate	70-87	microtubule associated protein tau	Homo sapiens	20-23
25842390-10	2015	By interacting with tau at the intracellular level, the 3-O-sulphated heparan sulphates produced by HS3ST2 might act as molecular chaperones allowing the abnormal phosphorylation of tau.	Heparitin Sulfate	70-87	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	Danio rerio	100-106
25842390-10	2015	By interacting with tau at the intracellular level, the 3-O-sulphated heparan sulphates produced by HS3ST2 might act as molecular chaperones allowing the abnormal phosphorylation of tau.	Heparitin Sulfate	70-87	microtubule associated protein tau	Homo sapiens	182-185
25527428-0	2015	Rapid nuclear transit and impaired degradation of amyloid beta and glypican-1-derived heparan sulfate in Tg2576 mouse fibroblasts.	Heparitin Sulfate	86-101	glypican 1	Mus musculus	67-77
25828531-3	2015	report that trimming of heparan sulfate side chains of syndecans by endosomal heparanase facilitates sorting into exosomes by the formation of tight syndecan clusters that are recruited by the multivalent adaptor syntenin to the ALIX-ESCRT sorting machinery at endosomes.	Heparitin Sulfate	24-39	syndecan binding protein	Homo sapiens	213-221
25828531-3	2015	report that trimming of heparan sulfate side chains of syndecans by endosomal heparanase facilitates sorting into exosomes by the formation of tight syndecan clusters that are recruited by the multivalent adaptor syntenin to the ALIX-ESCRT sorting machinery at endosomes.	Heparitin Sulfate	24-39	programmed cell death 6 interacting protein	Homo sapiens	229-233
25634957-1	2015	Heparanase, the exclusive mammalian heparan sulfate-degrading enzyme, has been suggested to be utilized by leukocytes to penetrate through the dense basement membranes surrounding blood venules.	Heparitin Sulfate	36-51	heparanase	Homo sapiens	0-10
25527428-1	2015	Anhydromannose (anMan)-containing heparan sulfate (HS) derived from S-nitrosylated glypican-1 is generated in endosomes by an endogenously or ascorbate induced S-nitrosothiol-catalyzed reaction.	Heparitin Sulfate	34-49	glypican 1	Mus musculus	83-93
25527428-1	2015	Anhydromannose (anMan)-containing heparan sulfate (HS) derived from S-nitrosylated glypican-1 is generated in endosomes by an endogenously or ascorbate induced S-nitrosothiol-catalyzed reaction.	Heparitin Sulfate	51-53	glypican 1	Mus musculus	83-93
25903683-11	2015	These observations indicated that pectin altered the sulfated structure of cell-surface HS to promote secretion of Wnt3a from differentiated Caco-2 cells and Wnt3a indirectly stimulated the proliferation of IEC-6 cells.	Heparitin Sulfate	88-90	Wnt family member 3A	Homo sapiens	115-120
25527428-6	2015	There was also greater nuclear accumulation of HS in Tg2576 MEF as determined by (35)S-sulfate-labeling experiments.	Heparitin Sulfate	47-49	E74-like factor 4 (ets domain transcription factor)	Mus musculus	60-63
25863062-4	2015	Upon investigating the specific interaction between the unique hydrophilic domain (HD) of the human cell-surface sulfatase Sulf1 against its physiological glycosaminoglycan (GAG) target heparan sulfate (HS) by single molecule force spectroscopy (SMFS), we found clear evidence of catch bond behavior in this system.	Heparitin Sulfate	186-201	sulfatase 1	Homo sapiens	123-128
25752613-2	2015	Heparan sulfate, a sulfated linear polysaccharide modified in a complex variety of ways, serves as an essential co-receptor in Slit-Robo signaling.	Heparitin Sulfate	0-15	roundabout 1	Drosophila melanogaster	132-136
25912399-3	2015	Here we demonstrate that a HS-degrading enzyme of the host, heparanase (HPSE), is upregulated through NF-kB and translocated to the cell surface upon HSV-1 infection for the removal of HS to facilitate viral release.	Heparitin Sulfate	27-29	heparanase	Homo sapiens	72-76
25863062-4	2015	Upon investigating the specific interaction between the unique hydrophilic domain (HD) of the human cell-surface sulfatase Sulf1 against its physiological glycosaminoglycan (GAG) target heparan sulfate (HS) by single molecule force spectroscopy (SMFS), we found clear evidence of catch bond behavior in this system.	Heparitin Sulfate	203-205	sulfatase 1	Homo sapiens	123-128
26131010-1	2015	BACKGROUND: Sulfatase 1 (SULF1) function is to remove the 6-O-sulphate group from heparan sulfate.	Heparitin Sulfate	82-97	sulfatase 1	Homo sapiens	12-23
25711986-10	2015	In fact, CE results confirmed the inductory effect of the sulfated sugars heparin and heparan sulfate on tau hyperphosphorylation, probably because of the exposition of new sites phosphorylatable by GSK3beta.	Heparitin Sulfate	86-101	glycogen synthase kinase 3 beta	Homo sapiens	199-207
25732677-10	2015	Taken together, our findings identify heparanase as a modulator of the syndecan-syntenin-ALIX pathway, fostering endosomal membrane budding and the biogenesis of exosomes by trimming the heparan sulfate chains on syndecans.	Heparitin Sulfate	187-202	syndecan 1	Homo sapiens	71-79
25732677-10	2015	Taken together, our findings identify heparanase as a modulator of the syndecan-syntenin-ALIX pathway, fostering endosomal membrane budding and the biogenesis of exosomes by trimming the heparan sulfate chains on syndecans.	Heparitin Sulfate	187-202	syndecan binding protein	Homo sapiens	80-88
25732677-10	2015	Taken together, our findings identify heparanase as a modulator of the syndecan-syntenin-ALIX pathway, fostering endosomal membrane budding and the biogenesis of exosomes by trimming the heparan sulfate chains on syndecans.	Heparitin Sulfate	187-202	programmed cell death 6 interacting protein	Homo sapiens	89-93
25367817-5	2015	The present work focuses on the P-selectin blocking activity of a unique heparan sulfate (HS) from the bivalve mollusk Nodipecten nodosus.	Heparitin Sulfate	73-88	selectin P	Homo sapiens	32-42
25367817-5	2015	The present work focuses on the P-selectin blocking activity of a unique heparan sulfate (HS) from the bivalve mollusk Nodipecten nodosus.	Heparitin Sulfate	90-92	selectin P	Homo sapiens	32-42
26131010-1	2015	BACKGROUND: Sulfatase 1 (SULF1) function is to remove the 6-O-sulphate group from heparan sulfate.	Heparitin Sulfate	82-97	sulfatase 1	Homo sapiens	25-30
25681501-3	2015	One such regulator is the heparan-sulfate-specific 6-O-endosulfatase Sulf1.	Heparitin Sulfate	26-41	sulfatase 1	Homo sapiens	69-74
25681501-4	2015	Sulf1 acts extracellularly to modify the structure of heparan sulfate chains to affect the bio-availability of Wnt ligands.	Heparitin Sulfate	54-69	sulfatase 1	Homo sapiens	0-5
25606800-9	2015	Heparan sulfate (HS), critical to establish CCL21 gradients, was down-regulated around lymphatics by anti-VEGFR-3 and this was dependent on heparanase-mediated degradation.	Heparitin Sulfate	0-15	C-C motif chemokine ligand 21	Homo sapiens	44-49
25606800-9	2015	Heparan sulfate (HS), critical to establish CCL21 gradients, was down-regulated around lymphatics by anti-VEGFR-3 and this was dependent on heparanase-mediated degradation.	Heparitin Sulfate	0-15	fms related receptor tyrosine kinase 4	Homo sapiens	106-113
25606800-9	2015	Heparan sulfate (HS), critical to establish CCL21 gradients, was down-regulated around lymphatics by anti-VEGFR-3 and this was dependent on heparanase-mediated degradation.	Heparitin Sulfate	17-19	C-C motif chemokine ligand 21	Homo sapiens	44-49
25606800-9	2015	Heparan sulfate (HS), critical to establish CCL21 gradients, was down-regulated around lymphatics by anti-VEGFR-3 and this was dependent on heparanase-mediated degradation.	Heparitin Sulfate	17-19	fms related receptor tyrosine kinase 4	Homo sapiens	106-113
25786136-1	2015	BACKGROUND: Heparanase, an endoglycosidase that cleaves heparan sulfate (HS), is involved in various biologic processes.	Heparitin Sulfate	56-71	heparanase	Mus musculus	12-22
25786136-1	2015	BACKGROUND: Heparanase, an endoglycosidase that cleaves heparan sulfate (HS), is involved in various biologic processes.	Heparitin Sulfate	73-75	heparanase	Mus musculus	12-22
25589788-5	2015	The combination of enzymatic, inhibitory, and overexpression approaches identified a heparan sulfate (HS) component of proteoglycans as an important determinant of the FXIIa binding capacity of HLF.	Heparitin Sulfate	85-100	HLF transcription factor, PAR bZIP family member	Homo sapiens	194-197
25614236-0	2015	The heparan sulfate-modifying enzyme glucuronyl C5-epimerase HSE-5 controls Caenorhabditis elegans Q neuroblast polarization during migration.	Heparitin Sulfate	4-19	D-glucuronyl C5-epimerase	Caenorhabditis elegans	61-66
25614236-3	2015	Here, we used the Caenorhabditis elegans mutant pool from the Million Mutation Project and isolated a mutant allele of the heparan sulfate-modifying enzyme glucuronyl C5-epimerase HSE-5.	Heparitin Sulfate	123-138	D-glucuronyl C5-epimerase	Caenorhabditis elegans	180-185
25589788-5	2015	The combination of enzymatic, inhibitory, and overexpression approaches identified a heparan sulfate (HS) component of proteoglycans as an important determinant of the FXIIa binding capacity of HLF.	Heparitin Sulfate	102-104	HLF transcription factor, PAR bZIP family member	Homo sapiens	194-197
25914755-7	2015	Depletion of heparan sulfate in young ECs elevated traction forces and actin filament thickness, while addition of heparan sulfate to the surface of aged ECs by treatment with angiopoietin-1 had the opposite effect.	Heparitin Sulfate	115-130	angiopoietin 1	Homo sapiens	176-190
25887999-1	2015	BACKGROUND: SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS).	Heparitin Sulfate	106-121	sulfatase 2	Homo sapiens	12-17
25887999-1	2015	BACKGROUND: SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS).	Heparitin Sulfate	123-125	sulfatase 2	Homo sapiens	12-17
27499864-1	2015	The heparan sulfate 6-O-endosulfatases sulf1 and sulf2 regulate multiple cellular processes and organ development.	Heparitin Sulfate	4-19	sulfatase 2 L homeolog	Xenopus laevis	49-54
25760599-0	2015	Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.	Heparitin Sulfate	83-98	amyloid beta precursor like protein 1	Homo sapiens	19-59
25760599-0	2015	Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.	Heparitin Sulfate	83-98	amyloid beta precursor like protein 1	Homo sapiens	61-66
25760599-2	2015	APP and its paralogues APP-like protein 1 (APLP1) and APP-like protein 2 (APLP2) contain the highly conserved heparan sulfate (HS) binding domain E2, which effects various (patho)physiological functions.	Heparitin Sulfate	110-125	amyloid beta precursor like protein 1	Homo sapiens	43-48
25760599-2	2015	APP and its paralogues APP-like protein 1 (APLP1) and APP-like protein 2 (APLP2) contain the highly conserved heparan sulfate (HS) binding domain E2, which effects various (patho)physiological functions.	Heparitin Sulfate	110-125	amyloid beta precursor like protein 2	Homo sapiens	74-79
25760599-2	2015	APP and its paralogues APP-like protein 1 (APLP1) and APP-like protein 2 (APLP2) contain the highly conserved heparan sulfate (HS) binding domain E2, which effects various (patho)physiological functions.	Heparitin Sulfate	127-129	amyloid beta precursor like protein 1	Homo sapiens	43-48
25760599-2	2015	APP and its paralogues APP-like protein 1 (APLP1) and APP-like protein 2 (APLP2) contain the highly conserved heparan sulfate (HS) binding domain E2, which effects various (patho)physiological functions.	Heparitin Sulfate	127-129	amyloid beta precursor like protein 2	Homo sapiens	74-79
25669977-0	2015	The heparan sulfate mimetic PG545 interferes with Wnt/beta-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine.	Heparitin Sulfate	4-19	catenin (cadherin associated protein), beta 1	Mus musculus	54-66
25548284-1	2015	Heparan sulfate (HS) and HS proteoglycans (HSPGs) colocalize with amyloid-beta (Abeta) deposits in Alzheimer disease brain and in Abeta precursor protein (AbetaPP) transgenic mouse models.	Heparitin Sulfate	0-15	amyloid beta (A4) precursor protein	Mus musculus	80-85
25573804-0	2015	Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-beta.	Heparitin Sulfate	0-15	interferon beta 1	Homo sapiens	68-76
25477293-1	2015	UNLABELLED: Heparan sulfate endosulfatase-1 and -2 (SULF1 and SULF2) are two important extracellular 6-O-endosulfatases that remove 6-O sulfate groups of N-glucosamine along heparan sulfate (HS) proteoglycan chains often found in the extracellular matrix.	Heparitin Sulfate	174-189	sulfatase 1	Homo sapiens	52-57
25477293-1	2015	UNLABELLED: Heparan sulfate endosulfatase-1 and -2 (SULF1 and SULF2) are two important extracellular 6-O-endosulfatases that remove 6-O sulfate groups of N-glucosamine along heparan sulfate (HS) proteoglycan chains often found in the extracellular matrix.	Heparitin Sulfate	174-189	sulfatase 2	Homo sapiens	62-67
25477293-1	2015	UNLABELLED: Heparan sulfate endosulfatase-1 and -2 (SULF1 and SULF2) are two important extracellular 6-O-endosulfatases that remove 6-O sulfate groups of N-glucosamine along heparan sulfate (HS) proteoglycan chains often found in the extracellular matrix.	Heparitin Sulfate	191-193	sulfatase 1	Homo sapiens	52-57
25477293-1	2015	UNLABELLED: Heparan sulfate endosulfatase-1 and -2 (SULF1 and SULF2) are two important extracellular 6-O-endosulfatases that remove 6-O sulfate groups of N-glucosamine along heparan sulfate (HS) proteoglycan chains often found in the extracellular matrix.	Heparitin Sulfate	191-193	sulfatase 2	Homo sapiens	62-67
25682080-1	2015	Heparanase is an endo-beta-glucuronidase that enzymatically cleaves heparan sulfates (HS) and heparan sulfate proteoglycan (HSPG) structures.	Heparitin Sulfate	68-84	glucuronidase beta	Homo sapiens	22-40
25682080-1	2015	Heparanase is an endo-beta-glucuronidase that enzymatically cleaves heparan sulfates (HS) and heparan sulfate proteoglycan (HSPG) structures.	Heparitin Sulfate	86-88	glucuronidase beta	Homo sapiens	22-40
25600805-6	2015	Other serpins, including antithrombin III and pigment epithelium-derived factor, were also degraded by heparan sulfate.	Heparitin Sulfate	103-118	serpin family F member 1	Homo sapiens	46-79
25711906-0	2015	Heparan sulfate provides a mechanism to respond to FGFR2b and control regenerative expansion.	Heparitin Sulfate	0-15	fibroblast growth factor receptor 2	Homo sapiens	51-56
25711906-2	2015	This is allowed by the synthesis of 3-O-sulfated heparan sulfate that up-regulate KIT and 3-O-sulfotransferase enzymes, augmenting 3-O-sulfated heparan sulfate.	Heparitin Sulfate	49-64	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	82-110
25711906-2	2015	This is allowed by the synthesis of 3-O-sulfated heparan sulfate that up-regulate KIT and 3-O-sulfotransferase enzymes, augmenting 3-O-sulfated heparan sulfate.	Heparitin Sulfate	144-159	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	82-110
25332157-0	2015	Oxidative stress is independent of inflammation in the neurodegenerative Sanfilippo syndrome type B. Mucopolysaccharidosis (MPS) type IIIB is a genetic deficiency of alpha-N-acetylglucosaminidase, inducing accumulation of partially degraded heparan sulfate (HS) oligosaccharides in tissues.	Heparitin Sulfate	241-256	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	166-195
25332157-0	2015	Oxidative stress is independent of inflammation in the neurodegenerative Sanfilippo syndrome type B. Mucopolysaccharidosis (MPS) type IIIB is a genetic deficiency of alpha-N-acetylglucosaminidase, inducing accumulation of partially degraded heparan sulfate (HS) oligosaccharides in tissues.	Heparitin Sulfate	258-260	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	166-195
25332157-2	2015	We have already shown that HS activates microglial cells through toll-like receptor 4 (TLR4) and triggers neuroinflammation.	Heparitin Sulfate	27-29	toll-like receptor 4	Mus musculus	65-85
25332157-2	2015	We have already shown that HS activates microglial cells through toll-like receptor 4 (TLR4) and triggers neuroinflammation.	Heparitin Sulfate	27-29	toll-like receptor 4	Mus musculus	87-91
25600805-1	2015	Heparan sulfate normally binds to heparin cofactor II and modulates the coagulation pathway by inhibiting thrombin.	Heparitin Sulfate	0-15	coagulation factor II, thrombin	Homo sapiens	106-114
25600805-5	2015	Heparan sulfate and dextran sulfate diminished the thrombin inhibitory activity of heparin cofactor II.	Heparitin Sulfate	0-15	coagulation factor II, thrombin	Homo sapiens	51-59
25600805-6	2015	Other serpins, including antithrombin III and pigment epithelium-derived factor, were also degraded by heparan sulfate.	Heparitin Sulfate	103-118	serpin family C member 1	Homo sapiens	25-41
25548284-1	2015	Heparan sulfate (HS) and HS proteoglycans (HSPGs) colocalize with amyloid-beta (Abeta) deposits in Alzheimer disease brain and in Abeta precursor protein (AbetaPP) transgenic mouse models.	Heparitin Sulfate	0-15	amyloid beta (A4) precursor protein	Mus musculus	130-135
25548284-1	2015	Heparan sulfate (HS) and HS proteoglycans (HSPGs) colocalize with amyloid-beta (Abeta) deposits in Alzheimer disease brain and in Abeta precursor protein (AbetaPP) transgenic mouse models.	Heparitin Sulfate	17-19	amyloid beta (A4) precursor protein	Mus musculus	80-85
25548284-1	2015	Heparan sulfate (HS) and HS proteoglycans (HSPGs) colocalize with amyloid-beta (Abeta) deposits in Alzheimer disease brain and in Abeta precursor protein (AbetaPP) transgenic mouse models.	Heparitin Sulfate	17-19	amyloid beta (A4) precursor protein	Mus musculus	130-135
26005591-5	2015	Heparanase is an endoglucuronidase that cleaves heparan sulfate chains of proteoglycans.	Heparitin Sulfate	48-63	heparanase	Homo sapiens	0-10
25567323-1	2015	Severe progressive neurological paediatric disease mucopolysaccharidosis III type C is caused by mutations in the HGSNAT gene leading to deficiency of acetyl-CoA: alpha-glucosaminide N-acetyltransferase involved in the lysosomal catabolism of heparan sulphate.	Heparitin Sulfate	243-259	heparan-alpha-glucosaminide N-acetyltransferase	Mus musculus	114-120
25624497-3	2015	GPC-4 showed strong (nanomolar) affinity and heparan sulfate (HS)-dependent interaction with the Ig domains of PTPsigma.	Heparitin Sulfate	45-60	glypican 4	Rattus norvegicus	0-5
25624497-3	2015	GPC-4 showed strong (nanomolar) affinity and heparan sulfate (HS)-dependent interaction with the Ig domains of PTPsigma.	Heparitin Sulfate	45-60	protein tyrosine phosphatase, receptor type, S	Rattus norvegicus	111-119
25624497-3	2015	GPC-4 showed strong (nanomolar) affinity and heparan sulfate (HS)-dependent interaction with the Ig domains of PTPsigma.	Heparitin Sulfate	62-64	glypican 4	Rattus norvegicus	0-5
25624497-3	2015	GPC-4 showed strong (nanomolar) affinity and heparan sulfate (HS)-dependent interaction with the Ig domains of PTPsigma.	Heparitin Sulfate	62-64	protein tyrosine phosphatase, receptor type, S	Rattus norvegicus	111-119
25643293-0	2015	Bovine lactoferrin inhibits Toscana virus infection by binding to heparan sulphate.	Heparitin Sulfate	66-82	lactotransferrin	Bos taurus	7-18
25246018-0	2015	The role of heparan sulfate as determining pathogenic factor in complement factor H-associated diseases.	Heparitin Sulfate	12-27	complement factor H	Homo sapiens	75-83
25351637-1	2015	CONTEXT AND OBJECTIVE: Heparanase-1 degrades heparan sulfate and has been correlated with tumor progression.	Heparitin Sulfate	45-60	heparanase	Homo sapiens	23-35
25600875-3	2015	Analysis of mutations in two exostosin glycosyltransferase genes (extl3 and ext2) revealed that loss of heparan sulfate (HS) chains results in a failure of collective cell migration due to enhanced Fgf ligand diffusion and loss of Fgf signal transduction.	Heparitin Sulfate	104-119	exostosin like glycosyltransferase 3	Homo sapiens	66-71
25408953-5	2015	The CIEF-MS analysis of several variants bearing punctual or deletion mutations within the two D1 and D2 basic clusters at the C-terminal end of IFN-gamma revealed the different contribution of these domains to the charge properties of this heparan sulfate-binding protein.	Heparitin Sulfate	241-256	interferon gamma	Homo sapiens	145-154
25600875-3	2015	Analysis of mutations in two exostosin glycosyltransferase genes (extl3 and ext2) revealed that loss of heparan sulfate (HS) chains results in a failure of collective cell migration due to enhanced Fgf ligand diffusion and loss of Fgf signal transduction.	Heparitin Sulfate	104-119	exostosin glycosyltransferase 2	Homo sapiens	76-80
25600875-3	2015	Analysis of mutations in two exostosin glycosyltransferase genes (extl3 and ext2) revealed that loss of heparan sulfate (HS) chains results in a failure of collective cell migration due to enhanced Fgf ligand diffusion and loss of Fgf signal transduction.	Heparitin Sulfate	121-123	exostosin like glycosyltransferase 3	Homo sapiens	66-71
25600875-3	2015	Analysis of mutations in two exostosin glycosyltransferase genes (extl3 and ext2) revealed that loss of heparan sulfate (HS) chains results in a failure of collective cell migration due to enhanced Fgf ligand diffusion and loss of Fgf signal transduction.	Heparitin Sulfate	121-123	exostosin glycosyltransferase 2	Homo sapiens	76-80
25404732-1	2015	The heparan sulfate proteoglycan syndecan-1 is proteolytically shed from the surface of multiple myeloma cells and is abundant in the bone marrow microenvironment where it promotes tumor growth, angiogenesis, and metastasis.	Heparitin Sulfate	4-19	syndecan 1	Homo sapiens	33-43
25404732-3	2015	Translocation of shed syndecan-1 (sSDC1) to the nucleus was blocked by addition of exogenous heparin or heparan sulfate, pretreatment of conditioned medium with heparinase III, or growth of cells in sodium chlorate, indicating that sulfated heparan sulfate chains are required for nuclear translocation.	Heparitin Sulfate	104-119	syndecan 1	Homo sapiens	22-32
25404732-3	2015	Translocation of shed syndecan-1 (sSDC1) to the nucleus was blocked by addition of exogenous heparin or heparan sulfate, pretreatment of conditioned medium with heparinase III, or growth of cells in sodium chlorate, indicating that sulfated heparan sulfate chains are required for nuclear translocation.	Heparitin Sulfate	241-256	syndecan 1	Homo sapiens	22-32
26053509-6	2015	The insulin"s ability to stimulate ILK was almost completely abolished when the cells were pre-incubated with heparinase III (HepIII), suggesting the heparan sulfates attached to syndecan-1 play an important role in the activation of ILK in response to insulin.	Heparitin Sulfate	150-166	integrin-linked kinase	Rattus norvegicus	35-38
26120938-8	2015	Surprisingly, aggressive metastatic cancer cells (U2020, DU145, KRC/Y) retained modification-oriented HS biosynthesis similar to normal PNT2 cells, possibly enabling the cells to keep like-to-normal cell surface glycosylation pattern to escape antimetastatic control.	Heparitin Sulfate	102-104	HIVEP zinc finger 3	Homo sapiens	64-67
25729613-5	2015	In particular, the common Y402H polymorphism affects the ability of FHL-1 and FH to localize to Bruch"s membrane and the inner choroid because it alters the ability of these complement regulators to bind heparan sulphate (HS) in these structures.	Heparitin Sulfate	204-220	four and a half LIM domains 1	Homo sapiens	68-73
25729613-5	2015	In particular, the common Y402H polymorphism affects the ability of FHL-1 and FH to localize to Bruch"s membrane and the inner choroid because it alters the ability of these complement regulators to bind heparan sulphate (HS) in these structures.	Heparitin Sulfate	204-220	complement factor H	Homo sapiens	68-70
25729613-5	2015	In particular, the common Y402H polymorphism affects the ability of FHL-1 and FH to localize to Bruch"s membrane and the inner choroid because it alters the ability of these complement regulators to bind heparan sulphate (HS) in these structures.	Heparitin Sulfate	222-224	four and a half LIM domains 1	Homo sapiens	68-73
25729613-5	2015	In particular, the common Y402H polymorphism affects the ability of FHL-1 and FH to localize to Bruch"s membrane and the inner choroid because it alters the ability of these complement regulators to bind heparan sulphate (HS) in these structures.	Heparitin Sulfate	222-224	complement factor H	Homo sapiens	68-70
26571129-1	2015	HPSE (heparanase) is the predominant enzyme in mammals capable of cleaving heparan sulfate, an activity highly implicated in cellular invasion and tumor metastasis.	Heparitin Sulfate	75-90	heparanase	Homo sapiens	0-4
26571129-1	2015	HPSE (heparanase) is the predominant enzyme in mammals capable of cleaving heparan sulfate, an activity highly implicated in cellular invasion and tumor metastasis.	Heparitin Sulfate	75-90	heparanase	Homo sapiens	6-16
25449226-7	2015	Association studies reveal TG2-syndecan-4 interaction through heparan sulphate side chains, and knockdown of syndecan-4 reduces cell surface TG2 activity and apoptotic cell clearance.	Heparitin Sulfate	62-78	syndecan 4	Homo sapiens	31-41
26236728-2	2015	Mentioned glycosaminoglycans chains are covalently O-linked to serine residues within the core proteins creating heparan sulfate/heparin proteoglycans (HSPG).	Heparitin Sulfate	113-128	syndecan 2	Homo sapiens	152-156
26307704-1	2015	Here we report ion mobility mass spectrometry (IMMS) separation and tandem mass spectrometry (MS(2)) sequencing methods used to analyze and differentiate six synthetically produced heparin/heparan sulfate (HS)-like octasaccharide (dp8) isomeric structures.	Heparitin Sulfate	189-204	dipeptidyl peptidase 8	Homo sapiens	231-234
26053509-6	2015	The insulin"s ability to stimulate ILK was almost completely abolished when the cells were pre-incubated with heparinase III (HepIII), suggesting the heparan sulfates attached to syndecan-1 play an important role in the activation of ILK in response to insulin.	Heparitin Sulfate	150-166	syndecan 1	Rattus norvegicus	179-189
26053509-6	2015	The insulin"s ability to stimulate ILK was almost completely abolished when the cells were pre-incubated with heparinase III (HepIII), suggesting the heparan sulfates attached to syndecan-1 play an important role in the activation of ILK in response to insulin.	Heparitin Sulfate	150-166	integrin-linked kinase	Rattus norvegicus	234-237
26053509-9	2015	These results strongly suggest that heparan sulfates on the syndecan-1 and/or shedding of syndecan-1 play a significant role in regulating ILK by insulin, and thereby regulating alkaline phosphatase and collagen synthesis in osteoblast cells.	Heparitin Sulfate	36-52	syndecan 1	Rattus norvegicus	60-70
26053509-9	2015	These results strongly suggest that heparan sulfates on the syndecan-1 and/or shedding of syndecan-1 play a significant role in regulating ILK by insulin, and thereby regulating alkaline phosphatase and collagen synthesis in osteoblast cells.	Heparitin Sulfate	36-52	syndecan 1	Rattus norvegicus	90-100
26053509-9	2015	These results strongly suggest that heparan sulfates on the syndecan-1 and/or shedding of syndecan-1 play a significant role in regulating ILK by insulin, and thereby regulating alkaline phosphatase and collagen synthesis in osteoblast cells.	Heparitin Sulfate	36-52	integrin-linked kinase	Rattus norvegicus	139-142
25521480-2	2014	Heparin, a soluble heparin sulfate (HS), can inhibit TCA HIV and FIV entry mediated by HSPG interaction in vitro.	Heparitin Sulfate	19-34	syndecan 2	Homo sapiens	87-91
25194470-2	2015	The heparan sulfate proteoglycan syndecan-1 (sdc1) has previously been shown to affect the response to arterial injury but has yet been studied in arteriogenesis.	Heparitin Sulfate	4-19	syndecan 1	Mus musculus	33-43
25194470-2	2015	The heparan sulfate proteoglycan syndecan-1 (sdc1) has previously been shown to affect the response to arterial injury but has yet been studied in arteriogenesis.	Heparitin Sulfate	4-19	syndecan 1	Mus musculus	45-49
25325980-0	2015	Heparan sulfate modulates Slit3-induced endothelial cell migration.	Heparitin Sulfate	0-15	slit guidance ligand 3	Mus musculus	26-31
25325980-3	2015	Here we describe using heparan sulfate-deficient mouse endothelial cells to determine the co-reception function of heparan sulfate in Slit3-induced endothelial cell migration in a Boyden chamber trans-well migration assay.	Heparitin Sulfate	23-38	slit guidance ligand 3	Mus musculus	134-139
25325980-3	2015	Here we describe using heparan sulfate-deficient mouse endothelial cells to determine the co-reception function of heparan sulfate in Slit3-induced endothelial cell migration in a Boyden chamber trans-well migration assay.	Heparitin Sulfate	115-130	slit guidance ligand 3	Mus musculus	134-139
25256447-8	2015	The concentration of HS in CSF in the patient with the attenuated phenotype of MPS IIIB 2 years after UCBT was very high and in the range of untreated MPS III patients.We conclude that the course of cognitive development, behavioral problems, and absence of biochemical correction in CSF demonstrate the absence of relevant effect of UCBT in MPS III patients, even when performed before clinical onset of CNS disease.	Heparitin Sulfate	21-23	N-acetyl-alpha-glucosaminidase	Homo sapiens	79-87
25325976-1	2015	Extracellular sulfatases (SULF1 and SULF2) selectively remove 6-O-sulfate groups from heparan sulfate proteoglycans (HSPGs) and by this process control important interactions of HSPGs with extracellular factors including morphogens, growth factors, and extracellular matrix components.	Heparitin Sulfate	86-101	sulfatase 1	Homo sapiens	26-31
25325976-1	2015	Extracellular sulfatases (SULF1 and SULF2) selectively remove 6-O-sulfate groups from heparan sulfate proteoglycans (HSPGs) and by this process control important interactions of HSPGs with extracellular factors including morphogens, growth factors, and extracellular matrix components.	Heparitin Sulfate	86-101	sulfatase 2	Homo sapiens	36-41
25359774-0	2014	Heparan sulfate inhibits hematopoietic stem and progenitor cell migration and engraftment in mucopolysaccharidosis I. Mucopolysaccharidosis I Hurler (MPSI-H) is a pediatric lysosomal storage disease caused by genetic deficiencies in IDUA, coding for alpha-l-iduronidase.	Heparitin Sulfate	0-15	alpha-L-iduronidase	Homo sapiens	233-237
25359774-0	2014	Heparan sulfate inhibits hematopoietic stem and progenitor cell migration and engraftment in mucopolysaccharidosis I. Mucopolysaccharidosis I Hurler (MPSI-H) is a pediatric lysosomal storage disease caused by genetic deficiencies in IDUA, coding for alpha-l-iduronidase.	Heparitin Sulfate	0-15	alpha-L-iduronidase	Homo sapiens	250-269
25359774-1	2014	Idua(-/-) mice share similar clinical pathology with patients, including the accumulation of the undegraded glycosaminoglycans (GAGs) heparan sulfate (HS), and dermatan sulfate (DS), progressive neurodegeneration, and dysostosis multiplex.	Heparitin Sulfate	134-149	iduronidase, alpha-L	Mus musculus	0-4
25359774-1	2014	Idua(-/-) mice share similar clinical pathology with patients, including the accumulation of the undegraded glycosaminoglycans (GAGs) heparan sulfate (HS), and dermatan sulfate (DS), progressive neurodegeneration, and dysostosis multiplex.	Heparitin Sulfate	151-153	iduronidase, alpha-L	Mus musculus	0-4
25521480-2	2014	Heparin, a soluble heparin sulfate (HS), can inhibit TCA HIV and FIV entry mediated by HSPG interaction in vitro.	Heparitin Sulfate	36-38	syndecan 2	Homo sapiens	87-91
25468659-0	2014	Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function.	Heparitin Sulfate	20-35	exostosin glycosyltransferase 2	Homo sapiens	62-67
25468659-3	2014	We studied the effect of heterozygous mutations in heparan sulfate elongation genes EXT1 and EXT2 on endothelial function in vitro as well as in vivo.	Heparitin Sulfate	51-66	exostosin glycosyltransferase 1	Homo sapiens	84-88
25468659-0	2014	Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function.	Heparitin Sulfate	20-35	exostosin glycosyltransferase 1	Homo sapiens	53-57
25468659-9	2014	CONCLUSIONS: Our data implicate that heparan sulfate elongation genes EXT1 and EXT2 are involved in maintaining endothelial homeostasis, presumably via increased nitric oxide bioavailability.	Heparitin Sulfate	37-52	exostosin glycosyltransferase 1	Homo sapiens	70-74
25468659-9	2014	CONCLUSIONS: Our data implicate that heparan sulfate elongation genes EXT1 and EXT2 are involved in maintaining endothelial homeostasis, presumably via increased nitric oxide bioavailability.	Heparitin Sulfate	37-52	exostosin glycosyltransferase 2	Homo sapiens	79-83
25399576-5	2014	The majority of angiogenic cytokines, including VEGF-A, FGF2, IL-8 and SDF-1alpha, manifest an obligate dependence on heparan sulfate (HS) for their biological activity.	Heparitin Sulfate	118-133	vascular endothelial growth factor A	Homo sapiens	48-54
25399576-5	2014	The majority of angiogenic cytokines, including VEGF-A, FGF2, IL-8 and SDF-1alpha, manifest an obligate dependence on heparan sulfate (HS) for their biological activity.	Heparitin Sulfate	135-137	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
25399576-5	2014	The majority of angiogenic cytokines, including VEGF-A, FGF2, IL-8 and SDF-1alpha, manifest an obligate dependence on heparan sulfate (HS) for their biological activity.	Heparitin Sulfate	118-133	fibroblast growth factor 2	Homo sapiens	56-60
25399576-5	2014	The majority of angiogenic cytokines, including VEGF-A, FGF2, IL-8 and SDF-1alpha, manifest an obligate dependence on heparan sulfate (HS) for their biological activity.	Heparitin Sulfate	118-133	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
25399576-5	2014	The majority of angiogenic cytokines, including VEGF-A, FGF2, IL-8 and SDF-1alpha, manifest an obligate dependence on heparan sulfate (HS) for their biological activity.	Heparitin Sulfate	135-137	vascular endothelial growth factor A	Homo sapiens	48-54
25286301-2	2014	PCPE-1 consists of two CUB domains that bind to the procollagen C-propeptide and are responsible for enhancing activity and a netrin-like (NTR) domain that binds to BMP-1 as well as heparin and heparan sulfate.	Heparitin Sulfate	194-209	procollagen C-endopeptidase enhancer	Homo sapiens	0-6
24752740-1	2014	Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2), an enzyme mediating 3-O-sulfation of heparan sulfate (HS), is silenced by hypermethylation in breast cancer.	Heparitin Sulfate	86-101	heparan sulfate-glucosamine 3-sulfotransferase 2	Homo sapiens	0-38
24752740-1	2014	Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2), an enzyme mediating 3-O-sulfation of heparan sulfate (HS), is silenced by hypermethylation in breast cancer.	Heparitin Sulfate	86-101	heparan sulfate-glucosamine 3-sulfotransferase 2	Homo sapiens	40-46
24752740-1	2014	Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2), an enzyme mediating 3-O-sulfation of heparan sulfate (HS), is silenced by hypermethylation in breast cancer.	Heparitin Sulfate	40-42	heparan sulfate-glucosamine 3-sulfotransferase 2	Homo sapiens	0-38
28649518-4	2015	Immunofluorescence analyses confirmed the down-regulated expression of some of these genes, in particular of the cartilage oligomeric matrix protein and osteopontin, encoded by COMP and SPP1, respectively, and showed the predominant reduction and disassembly of the heparan sulfate specific GAGs, as well as of the PG perlecan and type III and V collagens.	Heparitin Sulfate	266-281	secreted phosphoprotein 1	Homo sapiens	186-190
25558755-3	2014	These are caused by the deficiency or absence of alpha-L-iduronidase, essential to the metabolism of both dermatan and heparan sulfate, and it is encoded by the lDUA gene.	Heparitin Sulfate	119-134	alpha-L-iduronidase	Homo sapiens	49-68
25115442-0	2014	Granulin-epithelin precursor interacts with heparan sulfate on liver cancer cells.	Heparitin Sulfate	44-59	granulin precursor	Homo sapiens	0-18
25440058-4	2014	Diminished sulfation of heparan sulfate resulted in enhanced chemokine expression; increased macrophages in plaques; increased expression of ACAT2, a key enzyme in cholesterol ester storage; and increased foam cell conversion.	Heparitin Sulfate	24-39	acetyl-Coenzyme A acetyltransferase 2	Mus musculus	141-146
25305316-6	2014	FHL-1 is largely bound to Bruch"s membrane through interactions with heparan sulfate, and we show that the common Y402H polymorphism in the CFH gene, associated with an increased risk of AMD, reduces the binding of FHL-1 to this heparan sulfate.	Heparitin Sulfate	69-84	four and a half LIM domains 1	Homo sapiens	0-5
25305316-6	2014	FHL-1 is largely bound to Bruch"s membrane through interactions with heparan sulfate, and we show that the common Y402H polymorphism in the CFH gene, associated with an increased risk of AMD, reduces the binding of FHL-1 to this heparan sulfate.	Heparitin Sulfate	69-84	complement factor H	Homo sapiens	140-143
25305316-6	2014	FHL-1 is largely bound to Bruch"s membrane through interactions with heparan sulfate, and we show that the common Y402H polymorphism in the CFH gene, associated with an increased risk of AMD, reduces the binding of FHL-1 to this heparan sulfate.	Heparitin Sulfate	69-84	four and a half LIM domains 1	Homo sapiens	215-220
25305316-6	2014	FHL-1 is largely bound to Bruch"s membrane through interactions with heparan sulfate, and we show that the common Y402H polymorphism in the CFH gene, associated with an increased risk of AMD, reduces the binding of FHL-1 to this heparan sulfate.	Heparitin Sulfate	229-244	four and a half LIM domains 1	Homo sapiens	0-5
25305316-6	2014	FHL-1 is largely bound to Bruch"s membrane through interactions with heparan sulfate, and we show that the common Y402H polymorphism in the CFH gene, associated with an increased risk of AMD, reduces the binding of FHL-1 to this heparan sulfate.	Heparitin Sulfate	229-244	complement factor H	Homo sapiens	140-143
25305316-6	2014	FHL-1 is largely bound to Bruch"s membrane through interactions with heparan sulfate, and we show that the common Y402H polymorphism in the CFH gene, associated with an increased risk of AMD, reduces the binding of FHL-1 to this heparan sulfate.	Heparitin Sulfate	229-244	four and a half LIM domains 1	Homo sapiens	215-220
25385546-5	2014	Accordingly, heparan sulphate and heparin oligomers compete with TrkC for RPTPsigma binding in vitro and disrupt TrkC-dependent synaptic differentiation in neuronal co-culture assays.	Heparitin Sulfate	13-29	neurotrophic receptor tyrosine kinase 3	Homo sapiens	65-69
25385546-5	2014	Accordingly, heparan sulphate and heparin oligomers compete with TrkC for RPTPsigma binding in vitro and disrupt TrkC-dependent synaptic differentiation in neuronal co-culture assays.	Heparitin Sulfate	13-29	protein tyrosine phosphatase receptor type S	Homo sapiens	74-83
25385546-5	2014	Accordingly, heparan sulphate and heparin oligomers compete with TrkC for RPTPsigma binding in vitro and disrupt TrkC-dependent synaptic differentiation in neuronal co-culture assays.	Heparitin Sulfate	13-29	neurotrophic receptor tyrosine kinase 3	Homo sapiens	113-117
25202142-1	2014	The glycosyltransferase gene, Ext1, is essential for heparan sulfate production.	Heparitin Sulfate	53-68	exostosin glycosyltransferase 1	Mus musculus	30-34
25249499-11	2014	CONCLUSIONS: These results suggest that the HS side chains in perlecan are important mediators of the angiogenic response to ischemia through a mechanism that involves upregulation of VEGF expression.	Heparitin Sulfate	44-46	vascular endothelial growth factor A	Mus musculus	184-188
25459762-1	2014	Human alpha-L-iduronidase (IDUA) is a member of glycoside hydrolase family and is involved in the catabolism of glycosaminoglycans (GAGs), heparan sulfate (HS) and dermatan sulfate (DS).	Heparitin Sulfate	139-154	alpha-L-iduronidase	Homo sapiens	6-25
25344071-3	2014	We find that SDN-1 is the predominant heparan sulfate (HS) proteoglycan in the early C. elegans embryo, and that loss of HS biosynthesis or of the SDN-1 core protein results in misorientation of the spindle of the ABar blastomere.	Heparitin Sulfate	38-53	Syndecan;putative syndecan	Caenorhabditis elegans	13-18
25344071-3	2014	We find that SDN-1 is the predominant heparan sulfate (HS) proteoglycan in the early C. elegans embryo, and that loss of HS biosynthesis or of the SDN-1 core protein results in misorientation of the spindle of the ABar blastomere.	Heparitin Sulfate	55-57	Syndecan;putative syndecan	Caenorhabditis elegans	13-18
25194507-9	2014	Taken together, the data suggest a mechanism where fetuin-A, either endogenously synthesized or supplied extracellularly can extract histones from the nucleus or elsewhere in the cytosol/membrane and load them on cellular exosomes which then mediate adhesion by interacting with cell surface heparan sulfate proteoglycans via bound histones.	Heparitin Sulfate	292-307	alpha 2-HS glycoprotein	Homo sapiens	51-59
25049075-4	2014	Two heparin sulfate 3-O sulfotransferase (Hs3st) genes, Hs3st-A and Hs3st-B, encode the modification enzymes in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	112-127	Heparan sulfate 3-O sulfotransferase-A	Drosophila melanogaster	56-63
25049075-4	2014	Two heparin sulfate 3-O sulfotransferase (Hs3st) genes, Hs3st-A and Hs3st-B, encode the modification enzymes in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	112-127	Heparan sulfate 3-O sulfotransferase-B	Drosophila melanogaster	68-75
25049075-4	2014	Two heparin sulfate 3-O sulfotransferase (Hs3st) genes, Hs3st-A and Hs3st-B, encode the modification enzymes in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	129-131	Heparan sulfate 3-O sulfotransferase-A	Drosophila melanogaster	56-63
25049075-4	2014	Two heparin sulfate 3-O sulfotransferase (Hs3st) genes, Hs3st-A and Hs3st-B, encode the modification enzymes in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	129-131	Heparan sulfate 3-O sulfotransferase-B	Drosophila melanogaster	68-75
25459762-1	2014	Human alpha-L-iduronidase (IDUA) is a member of glycoside hydrolase family and is involved in the catabolism of glycosaminoglycans (GAGs), heparan sulfate (HS) and dermatan sulfate (DS).	Heparitin Sulfate	139-154	alpha-L-iduronidase	Homo sapiens	27-31
25459762-1	2014	Human alpha-L-iduronidase (IDUA) is a member of glycoside hydrolase family and is involved in the catabolism of glycosaminoglycans (GAGs), heparan sulfate (HS) and dermatan sulfate (DS).	Heparitin Sulfate	156-158	alpha-L-iduronidase	Homo sapiens	6-25
25459762-1	2014	Human alpha-L-iduronidase (IDUA) is a member of glycoside hydrolase family and is involved in the catabolism of glycosaminoglycans (GAGs), heparan sulfate (HS) and dermatan sulfate (DS).	Heparitin Sulfate	156-158	alpha-L-iduronidase	Homo sapiens	27-31
25386347-1	2014	Heparanase, a beta-D-endoglucuronidase abundant in platelets that was discovered 30 years ago, is an enzyme that cleaves heparan sulfate side chains on the cell surface and in the extracellular matrix.	Heparitin Sulfate	121-136	heparanase	Mus musculus	0-10
27896125-1	2014	Mucopolysaccharidosis type I (MPSI) is a rare autosomal recessive disorder caused by mutations in the gene encoding the lysosomal enzyme alpha-l-iduronidase (IDUA), which is instrumental in the hydrolysis of the glycosaminoglycans, dermatan and heparan sulfate.	Heparitin Sulfate	245-260	alpha-L-iduronidase	Homo sapiens	137-156
27896125-1	2014	Mucopolysaccharidosis type I (MPSI) is a rare autosomal recessive disorder caused by mutations in the gene encoding the lysosomal enzyme alpha-l-iduronidase (IDUA), which is instrumental in the hydrolysis of the glycosaminoglycans, dermatan and heparan sulfate.	Heparitin Sulfate	245-260	alpha-L-iduronidase	Homo sapiens	158-162
25176127-3	2014	Here, we report that heparan sulfate (HS) and chondroitin sulfate E (CSE) selectively regulate postsecretory trafficking of TIMP-3 by inhibiting its binding to LRP-1.	Heparitin Sulfate	21-36	TIMP metallopeptidase inhibitor 3	Homo sapiens	124-130
25176127-3	2014	Here, we report that heparan sulfate (HS) and chondroitin sulfate E (CSE) selectively regulate postsecretory trafficking of TIMP-3 by inhibiting its binding to LRP-1.	Heparitin Sulfate	21-36	LDL receptor related protein 1	Homo sapiens	160-165
25295599-0	2014	Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4.	Heparitin Sulfate	8-23	toll-like receptor 4	Mus musculus	116-121
25267636-2	2014	The cause is mutation in the gene encoding alpha-N-acetylglucosaminidase (NAGLU), deficiency of NAGLU, and accumulation of heparan sulfate.	Heparitin Sulfate	123-138	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	43-72
25043058-1	2014	Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation.	Heparitin Sulfate	87-103	fibroblast growth factor 1	Mus musculus	0-26
24753163-3	2014	RESULTS: To study HSPG-dependent coordination of these signaling pathways during mammalian visual system development, we have generated a series of OV-specific mutations in the heparan sulfate (HS) N-sulfotransferase genes (Ndst1 and Ndst2) and HS O-sulfotransferase genes (Hs2st, Hs6st1, and Hs6st2) in mice.	Heparitin Sulfate	177-192	syndecan 2	Homo sapiens	18-22
25156775-6	2014	The increased NDST1 then activated a heparan sulfate-related pathway involving activation of heparanase.	Heparitin Sulfate	37-52	N-deacetylase and N-sulfotransferase 1	Homo sapiens	14-19
25154787-1	2014	Syndecan-1 is a transmembrane heparan sulfate (HS) proteoglycan present on hepatocytes and involved in uptake of triglyceride-rich lipoproteins via its HS polysaccharide side chains.	Heparitin Sulfate	30-45	syndecan 1	Homo sapiens	0-10
25154787-1	2014	Syndecan-1 is a transmembrane heparan sulfate (HS) proteoglycan present on hepatocytes and involved in uptake of triglyceride-rich lipoproteins via its HS polysaccharide side chains.	Heparitin Sulfate	47-49	syndecan 1	Homo sapiens	0-10
24737657-1	2014	Heparanase is an endo-beta D-glucuronidase capable of cleaving heparan sulfate side chains, yielding heparan sulfate fragments.	Heparitin Sulfate	63-78	glucuronidase beta	Homo sapiens	22-42
24737657-1	2014	Heparanase is an endo-beta D-glucuronidase capable of cleaving heparan sulfate side chains, yielding heparan sulfate fragments.	Heparitin Sulfate	101-116	glucuronidase beta	Homo sapiens	22-42
25243896-9	2014	Moreover, radiolabeled HRG bound in a specific, heparan sulfate-independent manner, to differentiated human monocytic U937 cells in vitro.	Heparitin Sulfate	48-63	histidine rich glycoprotein	Homo sapiens	23-26
25043058-1	2014	Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation.	Heparitin Sulfate	87-103	fibroblast growth factor 1	Mus musculus	28-32
25230886-3	2014	EXT1 and EXT2, are tumor suppressor genes that encode glycosyltransferases involved in heparan sulfate elongation.	Heparitin Sulfate	87-102	exostosin glycosyltransferase 1	Homo sapiens	0-4
25230886-3	2014	EXT1 and EXT2, are tumor suppressor genes that encode glycosyltransferases involved in heparan sulfate elongation.	Heparitin Sulfate	87-102	exostosin glycosyltransferase 2	Homo sapiens	9-13
25231261-1	2014	BACKGROUND: Hunter Syndrome is an X-linked lysosomal storage disorder due to the deficit of iduronate 2-sulfatase, an enzyme catalysing the degradation of the glycosaminoglycans (GAG) dermatan- and heparan-sulfate.	Heparitin Sulfate	198-213	iduronate 2-sulfatase	Homo sapiens	92-113
24981920-2	2014	Herein, we report the first synthesis of a glycosaminoglycan family glycopeptide containing two different heparan sulfate chains, namely the extracellular domain of syndecan-3.	Heparitin Sulfate	106-121	syndecan 3	Homo sapiens	165-175
25024048-9	2014	Correlation analysis indicated a direct relationship between blood cell gene expression of MMP23B, involved in the breakdown of the extracellular matrix, and pain intensity, and an inverse relationship between blood cell gene expression of HS6ST1, responsible for 6-O-sulfation of heparan sulfate, and indicators of knee muscular strength.	Heparitin Sulfate	281-296	heparan sulfate 6-O-sulfotransferase 1	Homo sapiens	240-246
25034023-0	2014	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	Heparitin Sulfate	8-23	fibrillin 1	Homo sapiens	33-55
24937189-2	2014	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan-sulfate thus regulating the bioavailability of growth factors (FGF-2, TGF-beta).	Heparitin Sulfate	63-78	heparanase	Mus musculus	0-10
24937189-2	2014	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan-sulfate thus regulating the bioavailability of growth factors (FGF-2, TGF-beta).	Heparitin Sulfate	63-78	heparanase	Mus musculus	12-16
24937189-2	2014	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan-sulfate thus regulating the bioavailability of growth factors (FGF-2, TGF-beta).	Heparitin Sulfate	63-78	fibroblast growth factor 2	Mus musculus	134-139
24937189-2	2014	Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan-sulfate thus regulating the bioavailability of growth factors (FGF-2, TGF-beta).	Heparitin Sulfate	63-78	transforming growth factor, beta 1	Mus musculus	141-149
24880028-6	2014	CD8+ T cells are vital for clearance of WNF infected cells from the CNS, whereas TLR-3 and TLR-7 mediated anti-virus response through increased serum inflammatory cytokines to disrupt the BBB providing infected leucocytes and free virus access to the CNS (so called Trojan horse) Cellular virus attachment factors, promoting FV cell entry are widely distributed and include DC-SIGN (that detects complex carbohydrate molecules); Glycosamino glycans (GAG), Heparan sulphate(HSPG) Semaphorin 7A, Low Density Lipid receptors (LDLR); these are not FV specific virus entry receptors.	Heparitin Sulfate	456-472	toll like receptor 3	Equus caballus	81-86
24880028-6	2014	CD8+ T cells are vital for clearance of WNF infected cells from the CNS, whereas TLR-3 and TLR-7 mediated anti-virus response through increased serum inflammatory cytokines to disrupt the BBB providing infected leucocytes and free virus access to the CNS (so called Trojan horse) Cellular virus attachment factors, promoting FV cell entry are widely distributed and include DC-SIGN (that detects complex carbohydrate molecules); Glycosamino glycans (GAG), Heparan sulphate(HSPG) Semaphorin 7A, Low Density Lipid receptors (LDLR); these are not FV specific virus entry receptors.	Heparitin Sulfate	456-472	toll like receptor 7	Equus caballus	91-96
24959968-0	2014	Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.	Heparitin Sulfate	53-68	fibroblast growth factor 2	Homo sapiens	92-118
23761035-1	2014	Mucopolysaccharidosis-IIIB or Sanfilippo-B syndrome is caused by deficiency of lysosomal alpha-N-acetylglucosaminidase that leads to accumulation of heparan-sulphate and degeneration of central nervous system with progressive dementia, hyperactivity, and aggressive behavior.	Heparitin Sulfate	149-165	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	Homo sapiens	79-118
24911625-8	2014	This study investigated a single nucleotide polymorphism in SULF1, the enzyme responsible for the 6-O desulfation of heparan sulfate side chains.	Heparitin Sulfate	117-132	sulfatase 1	Homo sapiens	60-65
25101993-2	2014	Here, we report that loss of the heparan sulfate proteoglycan, syndecan-1, causes a profoundly depleted intradermal fat layer, which provides crucial thermogenic insulation for mammals.	Heparitin Sulfate	33-48	syndecan 1	Mus musculus	63-73
25098771-4	2014	Misexpressing the homolog of KAL-1/anosmin-1, a neural cell adhesion molecule mutant in Kallmann syndrome, in Caenorhabditis elegans causes a highly penetrant, heparan sulfate-dependent axonal branching phenotype in AIY interneurons.	Heparitin Sulfate	160-175	uncharacterized protein	Caenorhabditis elegans	29-34
25098771-7	2014	In addition, we show that heparan sulfate proteoglycan core proteins that carry the heparan sulfate chains act genetically in a highly redundant fashion to mediate kal-1-dependent branching in AIY neurons.	Heparitin Sulfate	26-41	uncharacterized protein	Caenorhabditis elegans	164-169
25098771-7	2014	In addition, we show that heparan sulfate proteoglycan core proteins that carry the heparan sulfate chains act genetically in a highly redundant fashion to mediate kal-1-dependent branching in AIY neurons.	Heparitin Sulfate	84-99	uncharacterized protein	Caenorhabditis elegans	164-169
25098771-9	2014	Because all of these heparan sulfate core proteins have been shown to act in different tissues, these studies indicate that KAL-1/anosmin-1 requires heparan sulfate with distinct modification patterns of different cellular origin for function.	Heparitin Sulfate	21-36	uncharacterized protein	Caenorhabditis elegans	124-129
25098771-9	2014	Because all of these heparan sulfate core proteins have been shown to act in different tissues, these studies indicate that KAL-1/anosmin-1 requires heparan sulfate with distinct modification patterns of different cellular origin for function.	Heparitin Sulfate	149-164	uncharacterized protein	Caenorhabditis elegans	124-129
25098771-10	2014	Our results support a model in which a three-dimensional scaffold of heparan sulfate mediates KAL-1/anosmin-1 and intercellular communication through complex and cooperative interactions.	Heparitin Sulfate	69-84	uncharacterized protein	Caenorhabditis elegans	94-99
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-X-C motif) ligand 1	Mus musculus	60-65
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-X-C motif) ligand 2	Mus musculus	67-72
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-X-C motif) ligand 2	Mus musculus	73-78
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-X-C motif) ligand 10	Mus musculus	80-85
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-X-C motif) ligand 10	Mus musculus	86-92
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-X-C motif) ligand 11	Mus musculus	97-102
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-X-C motif) ligand 11	Mus musculus	103-109
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-C motif) ligand 5	Mus musculus	131-137
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-C motif) ligand 5	Mus musculus	138-142
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-C motif) ligand 2	Mus musculus	239-244
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-C motif) ligand 2	Mus musculus	245-249
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-C motif) ligand 3	Mus musculus	251-261
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-C motif) ligand 3	Mus musculus	262-266
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-C motif) ligand 4	Mus musculus	271-280
25093679-4	2014	COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, MIP-1alpha/CCL3 and MIP-1beta/CCL4.	Heparitin Sulfate	9-25	chemokine (C-C motif) ligand 4	Mus musculus	281-285
24747732-1	2014	BACKGROUND: Heparanase is the only known mammalian glycosidase capable of cleaving heparan sulfate chains.	Heparitin Sulfate	83-98	heparanase	Homo sapiens	12-22
25034023-3	2014	We demonstrate the presence of heparin/heparan sulfate binding sites in fibrillin-2 and -3.	Heparitin Sulfate	39-54	fibrillin 2	Homo sapiens	72-90
25127119-5	2014	In this study, we characterized the substrate preferences of human HSulf2 using HS oligosaccharides with various lengths and sulfation degrees from several naturally occurring HS sources by applying liquid chromatography mass spectrometry based glycomics methods.	Heparitin Sulfate	80-82	sulfatase 2	Homo sapiens	67-73
24858854-3	2014	Hspg2(Delta3/Delta3) (MDelta3/Delta3) mice produce a mutant perlecan lacking the HS side chains.	Heparitin Sulfate	81-83	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	0-5
24858854-3	2014	Hspg2(Delta3/Delta3) (MDelta3/Delta3) mice produce a mutant perlecan lacking the HS side chains.	Heparitin Sulfate	81-83	delta like canonical Notch ligand 3	Mus musculus	14-20
24492943-0	2014	Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy.	Heparitin Sulfate	70-85	glypican 3	Mus musculus	96-106
24492943-7	2014	Then we report the identification of HS20, a human monoclonal antibody against GPC3, which preferentially recognized the heparan sulfate chains of GPC3, both the sulfated and nonsulfated portions.	Heparitin Sulfate	121-136	glypican 3	Mus musculus	79-83
24492943-7	2014	Then we report the identification of HS20, a human monoclonal antibody against GPC3, which preferentially recognized the heparan sulfate chains of GPC3, both the sulfated and nonsulfated portions.	Heparitin Sulfate	121-136	glypican 3	Mus musculus	147-151
24492943-11	2014	Taken together, our results show that a monoclonal antibody primarily targeting the heparin sulfate chains of GPC3 inhibited Wnt/beta-catenin signaling in HCC cells and had potent antitumor activity in vivo.	Heparitin Sulfate	84-99	glypican 3	Mus musculus	110-114
24492943-11	2014	Taken together, our results show that a monoclonal antibody primarily targeting the heparin sulfate chains of GPC3 inhibited Wnt/beta-catenin signaling in HCC cells and had potent antitumor activity in vivo.	Heparitin Sulfate	84-99	catenin (cadherin associated protein), beta 1	Mus musculus	129-141
24898256-0	2014	Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.	Heparitin Sulfate	159-174	amyloid beta (A4) precursor-like protein 2	Mus musculus	52-57
24874889-9	2014	Removal of cell surface heparan sulfate abrogated PLA2 and SB202190/BPB-PLA2 effect on ADAM17 maturation.	Heparitin Sulfate	24-39	phospholipase A2 group IB	Homo sapiens	50-54
24874889-9	2014	Removal of cell surface heparan sulfate abrogated PLA2 and SB202190/BPB-PLA2 effect on ADAM17 maturation.	Heparitin Sulfate	24-39	phospholipase A2 group IB	Homo sapiens	68-76
24874889-9	2014	Removal of cell surface heparan sulfate abrogated PLA2 and SB202190/BPB-PLA2 effect on ADAM17 maturation.	Heparitin Sulfate	24-39	ADAM metallopeptidase domain 17	Homo sapiens	87-93
24874889-11	2014	Moreover, the binding with heparan sulfate is crucial for the PLA2 effect.	Heparitin Sulfate	27-42	phospholipase A2 group IB	Homo sapiens	62-66
25074778-1	2014	PURPOSE: Heparan sulfate (HS) has been implicated in age-related macular degeneration (AMD), since it is the major binding partner for complement factor H (CFH) in human Bruch"s membrane (BrM), and CFH has a central role in inhibiting complement activation on extracellular matrices.	Heparitin Sulfate	9-24	complement factor H	Homo sapiens	135-154
25074778-1	2014	PURPOSE: Heparan sulfate (HS) has been implicated in age-related macular degeneration (AMD), since it is the major binding partner for complement factor H (CFH) in human Bruch"s membrane (BrM), and CFH has a central role in inhibiting complement activation on extracellular matrices.	Heparitin Sulfate	9-24	complement factor H	Homo sapiens	156-159
25074778-1	2014	PURPOSE: Heparan sulfate (HS) has been implicated in age-related macular degeneration (AMD), since it is the major binding partner for complement factor H (CFH) in human Bruch"s membrane (BrM), and CFH has a central role in inhibiting complement activation on extracellular matrices.	Heparitin Sulfate	9-24	complement factor H	Homo sapiens	198-201
25074778-1	2014	PURPOSE: Heparan sulfate (HS) has been implicated in age-related macular degeneration (AMD), since it is the major binding partner for complement factor H (CFH) in human Bruch"s membrane (BrM), and CFH has a central role in inhibiting complement activation on extracellular matrices.	Heparitin Sulfate	26-28	complement factor H	Homo sapiens	135-154
25074778-1	2014	PURPOSE: Heparan sulfate (HS) has been implicated in age-related macular degeneration (AMD), since it is the major binding partner for complement factor H (CFH) in human Bruch"s membrane (BrM), and CFH has a central role in inhibiting complement activation on extracellular matrices.	Heparitin Sulfate	26-28	complement factor H	Homo sapiens	156-159
25074778-1	2014	PURPOSE: Heparan sulfate (HS) has been implicated in age-related macular degeneration (AMD), since it is the major binding partner for complement factor H (CFH) in human Bruch"s membrane (BrM), and CFH has a central role in inhibiting complement activation on extracellular matrices.	Heparitin Sulfate	26-28	complement factor H	Homo sapiens	198-201
25074778-11	2014	CONCLUSIONS: The quantity of HS decreases substantially with age in human BrM, resulting in fewer binding sites for CFH and especially affecting the ability of the 402H variant of CFH to bind BrM.	Heparitin Sulfate	29-31	complement factor H	Homo sapiens	116-119
25074778-11	2014	CONCLUSIONS: The quantity of HS decreases substantially with age in human BrM, resulting in fewer binding sites for CFH and especially affecting the ability of the 402H variant of CFH to bind BrM.	Heparitin Sulfate	29-31	complement factor H	Homo sapiens	180-183
24898256-0	2014	Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.	Heparitin Sulfate	159-174	amyloid beta (A4) precursor protein	Mus musculus	0-25
24898256-0	2014	Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.	Heparitin Sulfate	159-174	amyloid beta (A4) precursor-like protein 2	Mus musculus	32-50
24898256-0	2014	Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.	Heparitin Sulfate	159-174	glypican 1	Mus musculus	140-150
24898256-1	2014	Anhydromannose (anMan)-containing heparan sulfate (HS) derived from the proteoglycan glypican-1 is generated in endosomes by an endogenously or ascorbate-induced S-nitrosothiolcatalyzed reaction.	Heparitin Sulfate	34-49	glypican 1	Mus musculus	85-95
24898256-1	2014	Anhydromannose (anMan)-containing heparan sulfate (HS) derived from the proteoglycan glypican-1 is generated in endosomes by an endogenously or ascorbate-induced S-nitrosothiolcatalyzed reaction.	Heparitin Sulfate	51-53	glypican 1	Mus musculus	85-95
24898256-4	2014	We showed by using deconvolution immunofluorescence microscopy with an anMan-specific monoclonal antibody as well as (35)S labeling experiments that expression of APP/APLP2 is required for ascorbate-induced transport of HS from endosomes to the nucleus.	Heparitin Sulfate	220-222	amyloid beta (A4) precursor-like protein 2	Mus musculus	167-172
25077071-0	2014	Carbohydrate-mediated modulation of NK cell receptor function: structural and functional influences of heparan sulfate moieties expressed on NK cell surface.	Heparitin Sulfate	103-118	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	36-52
25105093-3	2014	As substrates for the key enzymes sulfatases and heparanase, the modification of HSPGs is typically characterized by the degradation of heparan sulfate (HS) chains/sulfation patterns via the endo-6-O-sulfatases (Sulf1 and Sulf2) or by heparanase, an endo-glycosidase that cleaves the HS polymers releasing smaller fragments from HSPG complexes.	Heparitin Sulfate	136-151	sulfatase 1	Homo sapiens	212-217
25105093-3	2014	As substrates for the key enzymes sulfatases and heparanase, the modification of HSPGs is typically characterized by the degradation of heparan sulfate (HS) chains/sulfation patterns via the endo-6-O-sulfatases (Sulf1 and Sulf2) or by heparanase, an endo-glycosidase that cleaves the HS polymers releasing smaller fragments from HSPG complexes.	Heparitin Sulfate	136-151	sulfatase 2	Homo sapiens	222-227
25105093-3	2014	As substrates for the key enzymes sulfatases and heparanase, the modification of HSPGs is typically characterized by the degradation of heparan sulfate (HS) chains/sulfation patterns via the endo-6-O-sulfatases (Sulf1 and Sulf2) or by heparanase, an endo-glycosidase that cleaves the HS polymers releasing smaller fragments from HSPG complexes.	Heparitin Sulfate	81-83	sulfatase 1	Homo sapiens	212-217
25105093-3	2014	As substrates for the key enzymes sulfatases and heparanase, the modification of HSPGs is typically characterized by the degradation of heparan sulfate (HS) chains/sulfation patterns via the endo-6-O-sulfatases (Sulf1 and Sulf2) or by heparanase, an endo-glycosidase that cleaves the HS polymers releasing smaller fragments from HSPG complexes.	Heparitin Sulfate	81-83	sulfatase 2	Homo sapiens	222-227
25019288-4	2014	Our laboratory recently demonstrated that IL-2 is retained in blood vessels by heparan sulfate, and that biologically active IL-2 is released from vessel tissue by heparanase.	Heparitin Sulfate	79-94	interleukin 2	Mus musculus	42-46
24768893-2	2014	Post-synthetic remodelling of heparan sulphate (HS) by Sulf1 has been shown to modulate these same signalling pathways.	Heparitin Sulfate	30-46	sulfatase 1	Xenopus tropicalis	55-60
24768893-2	2014	Post-synthetic remodelling of heparan sulphate (HS) by Sulf1 has been shown to modulate these same signalling pathways.	Heparitin Sulfate	48-50	sulfatase 1	Xenopus tropicalis	55-60
24768893-3	2014	Sulf1 codes for an N-acetylglucosamine 6-O-endosulfatase, an enzyme that specifically removes the 6-O sulphate group from glucosamine in highly sulfated regions of HS chains.	Heparitin Sulfate	164-166	sulfatase 1	Xenopus tropicalis	0-5
25001284-2	2014	Using single-neuron laser axotomy and in vivo time-lapse imaging, we show that syndecan, a heparan sulfate (HS) proteoglycan, is required for growth cone function during axon regeneration in C. elegans.	Heparitin Sulfate	91-106	Syndecan;putative syndecan	Caenorhabditis elegans	79-87
25015005-8	2014	This was associated with diminished presence of CXCL1 at the luminal surface of synovial endothelial cells where this chemokine clustered and bound to heparan sulphate.	Heparitin Sulfate	151-167	chemokine (C-X-C motif) ligand 1	Mus musculus	48-53
25001284-2	2014	Using single-neuron laser axotomy and in vivo time-lapse imaging, we show that syndecan, a heparan sulfate (HS) proteoglycan, is required for growth cone function during axon regeneration in C. elegans.	Heparitin Sulfate	108-110	Syndecan;putative syndecan	Caenorhabditis elegans	79-87
24798737-1	2014	Perlecan/HSPG2 (Pln) is a large heparan sulfate proteoglycan abundant in the extracellular matrix of cartilage and the lacunocanalicular space of adult bones.	Heparitin Sulfate	32-47	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	9-14
24667567-1	2014	Heparanase, an endo-beta-glucuronidase cleaving heparan sulfate (HS) chains at cell surfaces and in the extracellular matrix (ECM), is involved in angiogenesis, tumor progression and metastasis as well as in inflammation and kidney dysfunction.	Heparitin Sulfate	48-63	glucuronidase beta	Homo sapiens	20-38
24667567-1	2014	Heparanase, an endo-beta-glucuronidase cleaving heparan sulfate (HS) chains at cell surfaces and in the extracellular matrix (ECM), is involved in angiogenesis, tumor progression and metastasis as well as in inflammation and kidney dysfunction.	Heparitin Sulfate	65-67	glucuronidase beta	Homo sapiens	20-38
24987005-2	2014	VEGF-B is produced as two isoforms: one that binds strongly to heparan sulfate in the pericellular matrix and a soluble form that can acquire binding via proteolytic processing.	Heparitin Sulfate	63-78	vascular endothelial growth factor B	Rattus norvegicus	0-6
25024924-2	2014	Neuropilin-1 (NRP-1) is a multidomain membrane protein with soluble isoforms interacting with a complex network of other membrane receptors, their respective ligands and heparan sulfate (HS).	Heparitin Sulfate	170-185	neuropilin 1	Homo sapiens	0-12
25024924-2	2014	Neuropilin-1 (NRP-1) is a multidomain membrane protein with soluble isoforms interacting with a complex network of other membrane receptors, their respective ligands and heparan sulfate (HS).	Heparitin Sulfate	170-185	neuropilin 1	Homo sapiens	14-19
25024924-2	2014	Neuropilin-1 (NRP-1) is a multidomain membrane protein with soluble isoforms interacting with a complex network of other membrane receptors, their respective ligands and heparan sulfate (HS).	Heparitin Sulfate	187-189	neuropilin 1	Homo sapiens	0-12
25024924-2	2014	Neuropilin-1 (NRP-1) is a multidomain membrane protein with soluble isoforms interacting with a complex network of other membrane receptors, their respective ligands and heparan sulfate (HS).	Heparitin Sulfate	187-189	neuropilin 1	Homo sapiens	14-19
25024924-14	2014	The results suggest that the interaction of NRP-1 with HS is more complex than anticipated and involving a far greater extent of the protein than just the b1-b2 domains.	Heparitin Sulfate	55-57	neuropilin 1	Homo sapiens	44-49
25024924-15	2014	NRP-1"s preference for binding long saccharide structures suggests it has the potential to bind large segments of HS chains and so organise their local structure.	Heparitin Sulfate	114-116	neuropilin 1	Homo sapiens	0-5
24960693-0	2014	Hs3st3-modified heparan sulfate controls KIT+ progenitor expansion by regulating 3-O-sulfotransferases.	Heparitin Sulfate	16-31	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	41-44
24920634-1	2014	The heparan sulfate proteoglycan Glypican 4 (Gpc4) is strongly expressed in mouse embryonic stem (ES) cells where it controls the maintenance of self-renewal by modulating Wnt/beta-catenin signaling activities.	Heparitin Sulfate	4-19	glypican 4	Mus musculus	33-43
24920634-1	2014	The heparan sulfate proteoglycan Glypican 4 (Gpc4) is strongly expressed in mouse embryonic stem (ES) cells where it controls the maintenance of self-renewal by modulating Wnt/beta-catenin signaling activities.	Heparitin Sulfate	4-19	glypican 4	Mus musculus	45-49
24920634-1	2014	The heparan sulfate proteoglycan Glypican 4 (Gpc4) is strongly expressed in mouse embryonic stem (ES) cells where it controls the maintenance of self-renewal by modulating Wnt/beta-catenin signaling activities.	Heparitin Sulfate	4-19	catenin (cadherin associated protein), beta 1	Mus musculus	176-188
24835176-5	2014	Among them, we identified a synthetic and not naturally occurring monosaccharide, 2,4-O-di-sulfated iduronic acid (Di-S-IdoA), as a potential inhibitor for CCL20-heparan sulfate interaction.	Heparitin Sulfate	162-177	chemokine (C-C motif) ligand 20	Mus musculus	156-161
24491019-0	2014	Apolipoprotein E increases cell association of amyloid-beta 40 through heparan sulfate and LRP1 dependent pathways.	Heparitin Sulfate	71-86	apolipoprotein E	Cricetulus griseus	0-16
25143170-1	2014	OBJECTIVE: To explore the effects of autotransplantation of NT-3 gene modified olfactory ensheathing cell (OEC) and neural stem cell (NSC) complex adhering to collagen protein-heparin sulfate scaffold on motor function of rats with cerebral hemorrhage.	Heparitin Sulfate	176-191	neurotrophin 3	Rattus norvegicus	60-64
24735886-11	2014	Both ECs and myocyte heparan sulfate proteoglycan-bound platelet-derived growth factor (PDGF) released by heparanase caused augmentation of GPIHBP1.	Heparitin Sulfate	21-36	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	Homo sapiens	140-147
24412195-8	2014	Differences in transcript expression of NDST1, HS6ST2 and HS6ST3, three heparan sulfate biosynthetic enzymes, within splanchnic mesoderm cells compared to H9 cells correlate to changes in glycosaminoglycan structure.	Heparitin Sulfate	72-87	N-deacetylase and N-sulfotransferase 1	Homo sapiens	40-45
24412195-8	2014	Differences in transcript expression of NDST1, HS6ST2 and HS6ST3, three heparan sulfate biosynthetic enzymes, within splanchnic mesoderm cells compared to H9 cells correlate to changes in glycosaminoglycan structure.	Heparitin Sulfate	72-87	heparan sulfate 6-O-sulfotransferase 2	Homo sapiens	47-53
24412195-8	2014	Differences in transcript expression of NDST1, HS6ST2 and HS6ST3, three heparan sulfate biosynthetic enzymes, within splanchnic mesoderm cells compared to H9 cells correlate to changes in glycosaminoglycan structure.	Heparitin Sulfate	72-87	heparan sulfate 6-O-sulfotransferase 3	Homo sapiens	58-64
24558194-2	2014	Recent studies show that raised level of SDC4, a cell-surface heparan sulfate (HS) proteoglycan, plays a role in pathogenesis of disc degeneration.	Heparitin Sulfate	62-77	syndecan 4	Homo sapiens	41-45
24684237-5	2014	The predicted targets of these miRNAs are clearly enriched in genes involved in heparan-sulfate biosynthesis, extracellular matrix-receptor interaction, carbohydrate digestion and absorption, p53 signaling, and cytokine-cytokine-receptor interaction.	Heparitin Sulfate	80-95	tumor protein p53	Homo sapiens	192-195
24833109-1	2014	Perlecan/HSPG2, a large heparan sulfate (HS) proteoglycan, normally is expressed in the basement membrane (BM) underlying epithelial and endothelial cells.	Heparitin Sulfate	24-39	heparan sulfate proteoglycan 2	Homo sapiens	9-14
25143170-10	2014	CONCLUSION: Autotransplantation of NT-3 gene modified OEC-NSC complex adhering to collagen protein-heparin sulfate scaffold may markedly ameliorate the motor function of cerebral hemorrhagic in rats.	Heparitin Sulfate	99-114	neurotrophin 3	Rattus norvegicus	35-39
24281389-2	2014	The attachment of AChE to the BL is primarily accomplished by the binding of the ColQ collagen domain to the heparan sulfate proteoglycan perlecan and the COOH-terminus to the muscle-specific receptor tyrosine kinase (MuSK), which in turn plays a fundamental role in the development and maintenance of the NMJ.	Heparitin Sulfate	109-124	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-22
24887057-1	2014	BACKGROUND: Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate chains of proteoglycans, resulting in the disassembly of the extracellular matrix.	Heparitin Sulfate	68-83	heparanase	Homo sapiens	12-22
24887057-1	2014	BACKGROUND: Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate chains of proteoglycans, resulting in the disassembly of the extracellular matrix.	Heparitin Sulfate	68-83	glucuronidase beta	Homo sapiens	34-54
24730525-2	2014	Fgf10 mediates biological responses by activating Fgf receptor 2b (Fgfr2b) with heparin/heparan sulfate in a paracrine manner.	Heparitin Sulfate	88-103	fibroblast growth factor 10	Mus musculus	0-5
24641902-5	2014	Heparan sulfate proteoglycan was shown to be involved in the association of ATX with blood cells.	Heparitin Sulfate	0-15	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	76-79
24641902-6	2014	The sequestration of ATX protein on the blood cells by heparan sulfate proteoglycan may accelerate the transport of LPA to the local apical surface of vascular endothelium with LPA receptors, promoting the hyperpermeability of venules and the pathological uptake of immune cells, aggravating lesion progression and itching in Naruto Research Institute Otsuka Atrichia mice.	Heparitin Sulfate	55-70	ectonucleotide pyrophosphatase/phosphodiesterase 2	Mus musculus	21-24
24530640-6	2014	Our results demonstrate that the major binding sites for RPTPsigma in adult mouse brain are on neurons and are not proteoglycan GAG chains, as RPTPsigma binding overlaps with the neuronal marker NeuN and was not significantly altered by treatments which eliminate chondroitin sulfate, heparan sulfate, or both.	Heparitin Sulfate	285-300	protein tyrosine phosphatase, receptor type, S	Mus musculus	57-66
24281389-2	2014	The attachment of AChE to the BL is primarily accomplished by the binding of the ColQ collagen domain to the heparan sulfate proteoglycan perlecan and the COOH-terminus to the muscle-specific receptor tyrosine kinase (MuSK), which in turn plays a fundamental role in the development and maintenance of the NMJ.	Heparitin Sulfate	109-124	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	81-85
24808863-13	2014	In this review we summarized the biochemical interactions of the proteins involved in the BMP/HJV/SMAD pathway and its natural inhibitors, the murine and rat models with high hepcidin levels currently available and finally the progresses in the development of hepcidin antagonists, with particular attention to the role of heparins and heparin sulfate proteoglycans in hepcidin expression and modulation of the BMP6/SMAD pathway.	Heparitin Sulfate	336-351	hepcidin antimicrobial peptide	Rattus norvegicus	260-268
24681169-0	2014	Bone morphogenetic protein-4 inhibits adult neurogenesis and is regulated by fractone-associated heparan sulfates in the subventricular zone.	Heparitin Sulfate	97-113	bone morphogenetic protein 4	Mus musculus	0-28
24681169-8	2014	Injection of heparitinase-1 was used to desulfate fractones and determine whether the binding and the effect of BMP-4 on cell proliferation are heparan sulfate-dependent.	Heparitin Sulfate	144-159	bone morphogenetic protein 4	Mus musculus	112-117
24681169-11	2014	Co-injection of heparitinase-1 and biotinylated-BMP-4 resulted in the absence of signal for biotinylated-BMP-4, indicating that the binding was heparan sulfate dependent.	Heparitin Sulfate	144-159	bone morphogenetic protein 4	Mus musculus	48-53
24681169-13	2014	These results show that BMP-4 inhibits cell proliferation in the SVZ neurogenic zone and that the binding of BMP-4 to fractone-associated heparan sulfates moderates this inhibitory effect.	Heparitin Sulfate	138-154	bone morphogenetic protein 4	Mus musculus	109-114
24862152-1	2014	Heparanase is an endo-beta-D-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix, activity that is strongly implicated in tumor metastasis and angiogenesis.	Heparitin Sulfate	71-86	glucuronidase beta	Homo sapiens	22-42
24357671-8	2014	Heparitinase I, which selectively cleaves heparan sulfate, completely abolished extracellular TG2 in normal and diseased kidney sections.	Heparitin Sulfate	42-57	transglutaminase 2, C polypeptide	Mus musculus	94-97
24357671-9	2014	In conclusion, the lack of Sdc4 heparan sulfate chains in the kidneys of Sdc4-null mice abrogates injury-induced externalization of TG2, thereby preventing profibrotic crosslinking of extracellular matrix and recruitment of large latent TGF-beta1.	Heparitin Sulfate	32-47	syndecan 4	Mus musculus	73-77
24357671-9	2014	In conclusion, the lack of Sdc4 heparan sulfate chains in the kidneys of Sdc4-null mice abrogates injury-induced externalization of TG2, thereby preventing profibrotic crosslinking of extracellular matrix and recruitment of large latent TGF-beta1.	Heparitin Sulfate	32-47	transglutaminase 2, C polypeptide	Mus musculus	132-135
24339435-1	2014	OBJECTIVE: Hepatic overexpression of sulfatase-2 (SULF2), a heparan sulfate remodeling enzyme, strongly contributes to high triglyceride (TG) levels in obese, type 2 diabetic (T2DM) db/db mice.	Heparitin Sulfate	60-75	sulfatase 2	Mus musculus	37-48
24339435-1	2014	OBJECTIVE: Hepatic overexpression of sulfatase-2 (SULF2), a heparan sulfate remodeling enzyme, strongly contributes to high triglyceride (TG) levels in obese, type 2 diabetic (T2DM) db/db mice.	Heparitin Sulfate	60-75	sulfatase 2	Mus musculus	50-55
24483599-1	2014	Hurler syndrome type 1 (MPS-1) is an autosomal recessive lysosomal disorder due to the deficiency of the enzyme alpha-L-iduronidase which is necessary for the degradation of dermatan and heparan sulfate.	Heparitin Sulfate	187-202	alpha-L-iduronidase	Homo sapiens	24-29
24483599-1	2014	Hurler syndrome type 1 (MPS-1) is an autosomal recessive lysosomal disorder due to the deficiency of the enzyme alpha-L-iduronidase which is necessary for the degradation of dermatan and heparan sulfate.	Heparitin Sulfate	187-202	alpha-L-iduronidase	Homo sapiens	112-131
24808863-13	2014	In this review we summarized the biochemical interactions of the proteins involved in the BMP/HJV/SMAD pathway and its natural inhibitors, the murine and rat models with high hepcidin levels currently available and finally the progresses in the development of hepcidin antagonists, with particular attention to the role of heparins and heparin sulfate proteoglycans in hepcidin expression and modulation of the BMP6/SMAD pathway.	Heparitin Sulfate	336-351	hepcidin antimicrobial peptide	Rattus norvegicus	260-268
23644656-1	2014	Heparan sulfate proteoglycans are an important and abundant component of the extracellular matrix, which undergo substantial remodeling throughout tumorigenesis via the enzymatic activity of heparanase.	Heparitin Sulfate	0-15	heparanase	Homo sapiens	191-201
23728345-2	2014	Recently, syndecan-1 (SDC1), a transmembrane heparan sulfate-bearing proteoglycan, was also speculated to have a critical role in contributing to angiogenesis when associated with MMP-9.	Heparitin Sulfate	45-60	syndecan 1	Mus musculus	10-20
23728345-2	2014	Recently, syndecan-1 (SDC1), a transmembrane heparan sulfate-bearing proteoglycan, was also speculated to have a critical role in contributing to angiogenesis when associated with MMP-9.	Heparitin Sulfate	45-60	syndecan 1	Mus musculus	22-26
24613844-1	2014	The cell surface heparan sulfate proteoglycan, syndecan-2, is known to play an important role in the tumorigenic activity of colon cancer cells.	Heparitin Sulfate	17-32	syndecan 2	Homo sapiens	47-57
24200809-5	2014	Moreover, WNT1-Cre/LoxP-mediated conditional targeting of NDST function in neural crest cells (NCCs) revealed that their impaired HS-dependent development contributes strongly to the observed cardiac defects.	Heparitin Sulfate	130-132	wingless-type MMTV integration site family, member 1	Mus musculus	10-14
24509075-6	2014	In addition, the heparan sulfate (HS) and chondroitin sulfate (CS) families of PGs interact directly with a number of growth factors, signalling pathways and ECM components including FGFs, Wnts and fibronectin.	Heparitin Sulfate	17-32	fibronectin 1	Homo sapiens	198-209
24509075-6	2014	In addition, the heparan sulfate (HS) and chondroitin sulfate (CS) families of PGs interact directly with a number of growth factors, signalling pathways and ECM components including FGFs, Wnts and fibronectin.	Heparitin Sulfate	34-36	fibronectin 1	Homo sapiens	198-209
24509440-6	2014	Smooth muscle cell perlecan bound both FGF1 and FGF2 via its heparan sulfate chains and promoted the signaling of FGF2 but not FGF1.	Heparitin Sulfate	61-76	fibroblast growth factor 1	Homo sapiens	39-43
24509440-6	2014	Smooth muscle cell perlecan bound both FGF1 and FGF2 via its heparan sulfate chains and promoted the signaling of FGF2 but not FGF1.	Heparitin Sulfate	61-76	fibroblast growth factor 2	Homo sapiens	48-52
24509440-7	2014	Also endothelial cell perlecan bound both FGF1 and FGF2 via its heparan sulfate chains, but in contrast, promoted the signaling of both growth factors.	Heparitin Sulfate	64-79	fibroblast growth factor 2	Homo sapiens	51-55
24409815-2	2014	MHE is largely caused by autosomal dominant mutations in EXT1 or EXT2, genes encoding Golgi-associated glycosyltransferases responsible for heparan sulfate (HS) synthesis.	Heparitin Sulfate	140-155	exostosin glycosyltransferase 1	Homo sapiens	57-61
24409815-2	2014	MHE is largely caused by autosomal dominant mutations in EXT1 or EXT2, genes encoding Golgi-associated glycosyltransferases responsible for heparan sulfate (HS) synthesis.	Heparitin Sulfate	140-155	exostosin glycosyltransferase 2	Homo sapiens	65-69
24409815-2	2014	MHE is largely caused by autosomal dominant mutations in EXT1 or EXT2, genes encoding Golgi-associated glycosyltransferases responsible for heparan sulfate (HS) synthesis.	Heparitin Sulfate	157-159	exostosin glycosyltransferase 1	Homo sapiens	57-61
24409815-2	2014	MHE is largely caused by autosomal dominant mutations in EXT1 or EXT2, genes encoding Golgi-associated glycosyltransferases responsible for heparan sulfate (HS) synthesis.	Heparitin Sulfate	157-159	exostosin glycosyltransferase 2	Homo sapiens	65-69
24176719-1	2014	The gene products of two members of the EXT gene family, EXT1 and EXT2, function together as a polymerase in the biosynthesis of heparan sulfate.	Heparitin Sulfate	129-144	exostosin glycosyltransferase 1	Mus musculus	57-61
24176719-1	2014	The gene products of two members of the EXT gene family, EXT1 and EXT2, function together as a polymerase in the biosynthesis of heparan sulfate.	Heparitin Sulfate	129-144	exostosin glycosyltransferase 2	Mus musculus	66-70
24451374-1	2014	The vaccinia viral protein A27 in mature viruses specifically interacts with heparan sulfate for cell surface attachment.	Heparitin Sulfate	77-92	immunoglobulin kappa variable 3-20	Homo sapiens	27-30
24488503-3	2014	A common link to many growth factor-dependent morphogenetic pathways is the involvement of variably sulfated heparan sulfates (HS), the glycosaminoglycan backbone of heparan sulfate proteoglycans (HSPG) on extracellular surfaces.	Heparitin Sulfate	127-129	syndecan 2	Homo sapiens	197-201
24744754-2	2014	A molecular view of the CFH interaction with native heparan sulfate (HS) is central for understanding the mechanism of how surface-bound CFH interacts with C3b bound to host cell surfaces.	Heparitin Sulfate	52-67	complement factor H	Homo sapiens	24-27
24744754-2	2014	A molecular view of the CFH interaction with native heparan sulfate (HS) is central for understanding the mechanism of how surface-bound CFH interacts with C3b bound to host cell surfaces.	Heparitin Sulfate	52-67	complement factor H	Homo sapiens	137-140
24744754-2	2014	A molecular view of the CFH interaction with native heparan sulfate (HS) is central for understanding the mechanism of how surface-bound CFH interacts with C3b bound to host cell surfaces.	Heparitin Sulfate	52-67	complement C3	Homo sapiens	156-159
24744754-2	2014	A molecular view of the CFH interaction with native heparan sulfate (HS) is central for understanding the mechanism of how surface-bound CFH interacts with C3b bound to host cell surfaces.	Heparitin Sulfate	69-71	complement factor H	Homo sapiens	24-27
24744754-2	2014	A molecular view of the CFH interaction with native heparan sulfate (HS) is central for understanding the mechanism of how surface-bound CFH interacts with C3b bound to host cell surfaces.	Heparitin Sulfate	69-71	complement factor H	Homo sapiens	137-140
24744754-2	2014	A molecular view of the CFH interaction with native heparan sulfate (HS) is central for understanding the mechanism of how surface-bound CFH interacts with C3b bound to host cell surfaces.	Heparitin Sulfate	69-71	complement C3	Homo sapiens	156-159
24497640-0	2014	Heparan sulfates mediate the interaction between platelet endothelial cell adhesion molecule-1 (PECAM-1) and the Galphaq/11 subunits of heterotrimeric G proteins.	Heparitin Sulfate	0-16	platelet and endothelial cell adhesion molecule 1	Homo sapiens	49-94
24497640-0	2014	Heparan sulfates mediate the interaction between platelet endothelial cell adhesion molecule-1 (PECAM-1) and the Galphaq/11 subunits of heterotrimeric G proteins.	Heparitin Sulfate	0-16	platelet and endothelial cell adhesion molecule 1	Homo sapiens	96-103
24497640-10	2014	Taken together, our results indicate that the PECAM-1 Galphaq/11 mechanosensitive complex contains an endogenous heparan sulfate proteoglycan with HS chains that is critical for junctional complex assembly and regulating the flow response.	Heparitin Sulfate	113-128	platelet and endothelial cell adhesion molecule 1	Homo sapiens	46-53
24281155-7	2014	RNAi against two additional genes in the heparan sulfate (HS) biosynthetic pathway (ttv and botv), in which sfl acts, also modified the eye phenotype in a hINS(C96Y)-dependent manner, strongly suggesting a novel link between HS-modified proteins and cellular responses to misfolded proteins.	Heparitin Sulfate	41-56	exostosin like glycosyltransferase 3	Homo sapiens	92-96
24326668-10	2014	Overexpression of Hs3st1 in MST-10H cells resulted in a change in the composition of heparan sulfate (HS)/HP and CS/dermatan sulfate (DS) glycosaminoglycans.	Heparitin Sulfate	85-100	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	Mus musculus	18-24
24326668-10	2014	Overexpression of Hs3st1 in MST-10H cells resulted in a change in the composition of heparan sulfate (HS)/HP and CS/dermatan sulfate (DS) glycosaminoglycans.	Heparitin Sulfate	102-104	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	Mus musculus	18-24
24046088-1	2014	Heparan sulfate proteoglycans are known to assist HIV-1 entry into host cells, mediated by the viral envelope glycoprotein gp120.	Heparitin Sulfate	0-15	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	123-128
24046088-4	2014	HIV-1 gp120 prefers heparin and heparan sulfate (with at least 16 monomers in length) over chondroitin and dermatan.	Heparitin Sulfate	32-47	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	6-11
24138091-2	2014	Recent reports have revealed that heparan sulphate (HS) proteoglycan, a component of extracellular matrices, potentiates the activation of intracellular pro-inflammatory responses via TLR4, contributing to the aggravation of acute pancreatitis.	Heparitin Sulfate	34-50	toll like receptor 4	Homo sapiens	184-188
24138091-2	2014	Recent reports have revealed that heparan sulphate (HS) proteoglycan, a component of extracellular matrices, potentiates the activation of intracellular pro-inflammatory responses via TLR4, contributing to the aggravation of acute pancreatitis.	Heparitin Sulfate	52-54	toll like receptor 4	Homo sapiens	184-188
24138091-7	2014	HS could also activate MaxiK channels to promote the efflux of potassium ions from cells, as measured by the elevated activity of caspase-1, whereas this was significantly abolished by treatment with paxilline, a specific blocker of the MaxiK channel.	Heparitin Sulfate	0-2	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	23-28
24138091-7	2014	HS could also activate MaxiK channels to promote the efflux of potassium ions from cells, as measured by the elevated activity of caspase-1, whereas this was significantly abolished by treatment with paxilline, a specific blocker of the MaxiK channel.	Heparitin Sulfate	0-2	caspase 1	Homo sapiens	130-139
24138091-7	2014	HS could also activate MaxiK channels to promote the efflux of potassium ions from cells, as measured by the elevated activity of caspase-1, whereas this was significantly abolished by treatment with paxilline, a specific blocker of the MaxiK channel.	Heparitin Sulfate	0-2	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	237-242
24480876-0	2014	Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1.	Heparitin Sulfate	60-75	nitric oxide synthase 3	Homo sapiens	14-29
24281155-7	2014	RNAi against two additional genes in the heparan sulfate (HS) biosynthetic pathway (ttv and botv), in which sfl acts, also modified the eye phenotype in a hINS(C96Y)-dependent manner, strongly suggesting a novel link between HS-modified proteins and cellular responses to misfolded proteins.	Heparitin Sulfate	58-60	exostosin like glycosyltransferase 3	Homo sapiens	92-96
24150912-1	2014	CD138 (syndecan-1, Sdc-1) is a member of the syndecan family that comprises heparan sulfate proteoglycans.	Heparitin Sulfate	76-91	syndecan 1	Homo sapiens	0-5
24242364-2	2014	Heparin and heparan sulfates (HS) have been reported to be high-affinity ligands for fibronectin.	Heparitin Sulfate	12-28	fibronectin 1	Homo sapiens	85-96
24242364-2	2014	Heparin and heparan sulfates (HS) have been reported to be high-affinity ligands for fibronectin.	Heparitin Sulfate	30-32	fibronectin 1	Homo sapiens	85-96
24242364-5	2014	Heparin, which is more sulfated than HS, is a better ligand for fibronectin, indicating that the sulfate density is important for the interactions.	Heparitin Sulfate	37-39	fibronectin 1	Homo sapiens	64-75
24150912-1	2014	CD138 (syndecan-1, Sdc-1) is a member of the syndecan family that comprises heparan sulfate proteoglycans.	Heparitin Sulfate	76-91	syndecan 1	Homo sapiens	7-17
24150912-1	2014	CD138 (syndecan-1, Sdc-1) is a member of the syndecan family that comprises heparan sulfate proteoglycans.	Heparitin Sulfate	76-91	syndecan 1	Homo sapiens	19-24
24148803-2	2014	Although LTBP-2 binds fibrillin-1, fibulin-5, and heparin/heparan sulfate, molecules critical for normal elastic fiber assembly, it does not interact directly with elastin or its precursor, tropoelastin.	Heparitin Sulfate	58-73	latent transforming growth factor beta binding protein 2	Homo sapiens	9-15
24048373-4	2014	Heparin releases sFlt-1 by displacing the sFlt-1 heparin-binding site from heparin sulfate proteoglycans.	Heparitin Sulfate	75-90	FMS-like tyrosine kinase 1	Mus musculus	17-23
24048373-4	2014	Heparin releases sFlt-1 by displacing the sFlt-1 heparin-binding site from heparin sulfate proteoglycans.	Heparitin Sulfate	75-90	FMS-like tyrosine kinase 1	Mus musculus	42-48
23924956-4	2014	A novel mutant mouse (Ndst1(-/-)) was developed, having podocyte-specific deletion of Ndst1, the enzyme responsible for N-sulfation of heparan sulfate chains.	Heparitin Sulfate	135-150	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	22-27
23924956-4	2014	A novel mutant mouse (Ndst1(-/-)) was developed, having podocyte-specific deletion of Ndst1, the enzyme responsible for N-sulfation of heparan sulfate chains.	Heparitin Sulfate	135-150	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	86-91
24368159-1	2014	UNLABELLED: The lysosomal enzyme alpha-L-iduronidase hydrolyzes terminal iduronic acid from heparan sulfate and dermatan sulfate, and is an essential step in GAG degradation.	Heparitin Sulfate	92-107	alpha-L-iduronidase	Homo sapiens	33-52
24297320-3	2014	Mutations of EXT1 or EXT2 result in insufficient heparan sulfate biosynthesis, which facilitates chondrocyte proliferation, boosts abnormal bone growth of neighboring regions, causes multiple exostoses, and ultimately leads to possible malignant transformation.	Heparitin Sulfate	49-64	exostosin glycosyltransferase 1	Homo sapiens	13-17
24297320-3	2014	Mutations of EXT1 or EXT2 result in insufficient heparan sulfate biosynthesis, which facilitates chondrocyte proliferation, boosts abnormal bone growth of neighboring regions, causes multiple exostoses, and ultimately leads to possible malignant transformation.	Heparitin Sulfate	49-64	exostosin glycosyltransferase 2	Homo sapiens	21-25
24148804-2	2014	Heparin and heparan sulfate, for example, have been shown to regulate the sequestration and presentation of numerous growth factors, including vascular endothelial growth factor, on the heparin 2 binding domain in fibronectin (Fn).	Heparitin Sulfate	12-27	vascular endothelial growth factor A	Homo sapiens	143-177
24148803-11	2014	Overall the results indicate that LTBP-2 may have a negative regulatory role during elastic fiber assembly, perhaps in displacing elastin microassemblies from complexes with fibulin-5 and/or cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	204-219	latent transforming growth factor beta binding protein 2	Homo sapiens	34-40
24148804-2	2014	Heparin and heparan sulfate, for example, have been shown to regulate the sequestration and presentation of numerous growth factors, including vascular endothelial growth factor, on the heparin 2 binding domain in fibronectin (Fn).	Heparitin Sulfate	12-27	fibronectin 1	Homo sapiens	214-225
24148804-2	2014	Heparin and heparan sulfate, for example, have been shown to regulate the sequestration and presentation of numerous growth factors, including vascular endothelial growth factor, on the heparin 2 binding domain in fibronectin (Fn).	Heparitin Sulfate	12-27	fibronectin 1	Homo sapiens	227-229
24291708-1	2014	Heparanase is an endo-beta-glucuronidase that cleaves heparan sulfate side chains of proteoglycans in basement membranes and the extracellular matrix (ECM).	Heparitin Sulfate	54-69	heparanase	Homo sapiens	0-10
24291708-1	2014	Heparanase is an endo-beta-glucuronidase that cleaves heparan sulfate side chains of proteoglycans in basement membranes and the extracellular matrix (ECM).	Heparitin Sulfate	54-69	glucuronidase beta	Homo sapiens	22-40
23918206-9	2014	Additionally, we could identify heparan-sulfates as important co-factor of secretoneurin induced binding of basic fibroblast growth factor to human dermal endothelial cells.	Heparitin Sulfate	32-48	secretogranin II	Homo sapiens	75-88
23959107-0	2014	The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity.	Heparitin Sulfate	4-19	sulfatase 1	Danio rerio	35-40
23959107-2	2014	The activities of VEGF, are in part controlled by heparan sulfate (HS) proteoglycans, significant components of the endothelial glycocalyx.	Heparitin Sulfate	50-65	vascular endothelial growth factor Aa	Danio rerio	18-22
23959107-2	2014	The activities of VEGF, are in part controlled by heparan sulfate (HS) proteoglycans, significant components of the endothelial glycocalyx.	Heparitin Sulfate	67-69	vascular endothelial growth factor Aa	Danio rerio	18-22
23959107-0	2014	The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity.	Heparitin Sulfate	4-19	vascular endothelial growth factor Aa	Danio rerio	73-78
25035978-0	2014	Structural alteration of cell surface heparan sulfate through the stimulation of the signaling pathway for heparan sulfate 6-O-sulfotransferase-1 in mouse fibroblast cells.	Heparitin Sulfate	38-53	heparan sulfate 6-O-sulfotransferase 1	Mus musculus	107-145
25138526-1	2014	Spock3/Testican-3 is a nervous system-expressed heparan sulfate proteoglycan belonging to a subgroup of the BM-40/SPARC/osteonectin family, the role of which in brain development is unclear.	Heparitin Sulfate	48-63	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3	Mus musculus	0-6
24568197-1	2014	Heparanase is the unique and specific functional endoglycosidase capable of cleaving heparan sulfate (HS) chains.	Heparitin Sulfate	85-100	heparanase	Homo sapiens	0-10
24568197-1	2014	Heparanase is the unique and specific functional endoglycosidase capable of cleaving heparan sulfate (HS) chains.	Heparitin Sulfate	102-104	heparanase	Homo sapiens	0-10
25138526-1	2014	Spock3/Testican-3 is a nervous system-expressed heparan sulfate proteoglycan belonging to a subgroup of the BM-40/SPARC/osteonectin family, the role of which in brain development is unclear.	Heparitin Sulfate	48-63	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3	Mus musculus	7-17
25138526-1	2014	Spock3/Testican-3 is a nervous system-expressed heparan sulfate proteoglycan belonging to a subgroup of the BM-40/SPARC/osteonectin family, the role of which in brain development is unclear.	Heparitin Sulfate	48-63	secreted acidic cysteine rich glycoprotein	Mus musculus	120-131
24555114-1	2013	Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains.	Heparitin Sulfate	64-80	syndecan 3	Homo sapiens	0-10
25668674-0	2014	Gene expression profiles identify both MyD88-independent and MyD88-dependent pathways involved in the maturation of dendritic cells mediated by heparan sulfate: a novel adjuvant.	Heparitin Sulfate	144-159	MYD88 innate immune signal transduction adaptor	Homo sapiens	39-44
25668674-0	2014	Gene expression profiles identify both MyD88-independent and MyD88-dependent pathways involved in the maturation of dendritic cells mediated by heparan sulfate: a novel adjuvant.	Heparitin Sulfate	144-159	MYD88 innate immune signal transduction adaptor	Homo sapiens	61-66
25668674-2	2014	We previously demonstrated that heparan sulfate (HS), a TLR-4 ligand and endogenous danger signal, effectively enhanced humoral and cellular immune responses in mice immunized by HBsAg.	Heparitin Sulfate	32-47	toll-like receptor 4	Mus musculus	56-61
25668674-2	2014	We previously demonstrated that heparan sulfate (HS), a TLR-4 ligand and endogenous danger signal, effectively enhanced humoral and cellular immune responses in mice immunized by HBsAg.	Heparitin Sulfate	49-51	toll-like receptor 4	Mus musculus	56-61
24101444-5	2014	We hypothesized that loss of Ndst1 in smooth muscle would lead to significant changes in heparan sulfate modification and the elastic properties of arteries.	Heparitin Sulfate	89-104	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	29-34
24421779-1	2013	Heparanase (Hpse) is the only known mammalian endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS), found attached to the core proteins of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	108-123	heparanase	Homo sapiens	0-10
24421779-1	2013	Heparanase (Hpse) is the only known mammalian endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS), found attached to the core proteins of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	108-123	heparanase	Homo sapiens	12-16
24421779-1	2013	Heparanase (Hpse) is the only known mammalian endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS), found attached to the core proteins of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	125-127	heparanase	Homo sapiens	0-10
24421779-1	2013	Heparanase (Hpse) is the only known mammalian endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS), found attached to the core proteins of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	125-127	heparanase	Homo sapiens	12-16
24421779-1	2013	Heparanase (Hpse) is the only known mammalian endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS), found attached to the core proteins of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	169-184	heparanase	Homo sapiens	0-10
24421779-1	2013	Heparanase (Hpse) is the only known mammalian endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS), found attached to the core proteins of heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	169-184	heparanase	Homo sapiens	12-16
24421779-4	2013	In the non-obese diabetic (NOD) model of autoimmune Type 1 diabetes (T1D), Hpse is also used by insulitis leukocytes to solubilize the islet BM to enable intra-islet entry of leukocytes and to degrade intracellular HS, an essential component for the survival of insulin-producing islet beta cells.	Heparitin Sulfate	215-217	heparanase	Homo sapiens	75-79
24355925-2	2014	In this study, we report that ablation of the heparan sulfate biosynthetic enzyme NDST1 in murine endothelium (Ndst1ECKO mice) disrupted vascular development in the diaphragm, which led to hypoxia as well as subsequent diaphragm hypoplasia and CDH.	Heparitin Sulfate	46-61	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	82-87
24355925-5	2014	NDST1 deficiency diminished SLIT3, but not ROBO4, binding to endothelial heparan sulfate and attenuated EC migration and in vivo neovascularization normally elicited by SLIT3-ROBO4 signaling.	Heparitin Sulfate	73-88	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	0-5
24355925-6	2014	Together, these data suggest that heparan sulfate presentation of SLIT3 to ROBO4 facilitates initiation of this signaling cascade.	Heparitin Sulfate	34-49	slit guidance ligand 3	Mus musculus	66-71
24355925-6	2014	Together, these data suggest that heparan sulfate presentation of SLIT3 to ROBO4 facilitates initiation of this signaling cascade.	Heparitin Sulfate	34-49	roundabout guidance receptor 4	Mus musculus	75-80
24355925-7	2014	Thus, our results demonstrate that loss of NDST1 causes defective diaphragm vascular development and CDH and that heparan sulfate facilitates angiogenic SLIT3-ROBO4 signaling during vascular development.	Heparitin Sulfate	114-129	slit guidance ligand 3	Mus musculus	153-158
24355925-7	2014	Thus, our results demonstrate that loss of NDST1 causes defective diaphragm vascular development and CDH and that heparan sulfate facilitates angiogenic SLIT3-ROBO4 signaling during vascular development.	Heparitin Sulfate	114-129	roundabout guidance receptor 4	Mus musculus	159-164
24335201-3	2014	CFH, in conjunction with other factors, regulates complement activation in host tissues, and the Y402H polymorphism has been found to alter the protein"s specificity for heparan sulphate (HS) - a complex polysaccharide found ubiquitously in mammals.	Heparitin Sulfate	188-190	complement factor H	Homo sapiens	0-3
24678194-1	2014	INTRODUCTION: Antithrombin, the principal inhibitor of coagulation proteases, requires allosteric activation by its physiological cofactor, heparin or heparin sulfate to achieve physiologically permissible rates.	Heparitin Sulfate	151-166	serpin family C member 1	Homo sapiens	14-26
24392351-0	2013	The role of syndecan-1 in cellular signaling and its effects on heparan sulfate biosynthesis in mesenchymal tumors.	Heparitin Sulfate	64-79	syndecan 1	Homo sapiens	12-22
24392351-10	2013	Overexpression of syndecan-1 modulates the biosynthesis and sulfation of heparan sulfate and it also affects the expression of other PGs.	Heparitin Sulfate	73-88	syndecan 1	Homo sapiens	18-28
24026238-0	2013	Non-toxic amyloid beta formed in the presence of glypican-1 or its deaminatively generated heparan sulfate degradation products.	Heparitin Sulfate	91-106	glypican 1	Mus musculus	49-59
24026238-2	2013	Interestingly, APP binds strongly to the heparan sulfate (HS) proteoglycan (PG) glypican-1 (Gpc-1) in vitro and both proteins are colocalized inside cells.	Heparitin Sulfate	41-56	glypican 1	Mus musculus	80-90
24026238-2	2013	Interestingly, APP binds strongly to the heparan sulfate (HS) proteoglycan (PG) glypican-1 (Gpc-1) in vitro and both proteins are colocalized inside cells.	Heparitin Sulfate	41-56	glypican 1	Mus musculus	92-97
24026238-2	2013	Interestingly, APP binds strongly to the heparan sulfate (HS) proteoglycan (PG) glypican-1 (Gpc-1) in vitro and both proteins are colocalized inside cells.	Heparitin Sulfate	58-60	glypican 1	Mus musculus	80-90
24026238-2	2013	Interestingly, APP binds strongly to the heparan sulfate (HS) proteoglycan (PG) glypican-1 (Gpc-1) in vitro and both proteins are colocalized inside cells.	Heparitin Sulfate	58-60	glypican 1	Mus musculus	92-97
24371161-1	2013	The heparan sulfate 6-O-sulfotransferase 3 (HS6ST3) gene is involved in heparan sulphate and heparin metabolism, and has been reported to be associated with diabetic retinopathy in type 2 diabetes.We hypothesized that HS6ST3 gene polymorphisms might play an important role in obesity and related phenotypes (such as triglycerides).	Heparitin Sulfate	72-88	heparan sulfate 6-O-sulfotransferase 3	Homo sapiens	4-42
24371161-1	2013	The heparan sulfate 6-O-sulfotransferase 3 (HS6ST3) gene is involved in heparan sulphate and heparin metabolism, and has been reported to be associated with diabetic retinopathy in type 2 diabetes.We hypothesized that HS6ST3 gene polymorphisms might play an important role in obesity and related phenotypes (such as triglycerides).	Heparitin Sulfate	72-88	heparan sulfate 6-O-sulfotransferase 3	Homo sapiens	44-50
24371161-1	2013	The heparan sulfate 6-O-sulfotransferase 3 (HS6ST3) gene is involved in heparan sulphate and heparin metabolism, and has been reported to be associated with diabetic retinopathy in type 2 diabetes.We hypothesized that HS6ST3 gene polymorphisms might play an important role in obesity and related phenotypes (such as triglycerides).	Heparitin Sulfate	72-88	heparan sulfate 6-O-sulfotransferase 3	Homo sapiens	218-224
24026183-5	2013	CD44v3-v10 (CD44v3) has heparan sulfate moieties, which enable the binding to HGF/BMP-7, and hence, might exert renoprotective effects.	Heparitin Sulfate	24-39	hepatocyte growth factor	Mus musculus	78-81
24133213-1	2013	During the biosynthesis of heparan sulfate (HS), glucuronyl C5-epimerase (Hsepi) catalyzes C5-epimerization of glucuronic acid (GlcA), converting it to iduronic acid (IdoA).	Heparitin Sulfate	27-42	Heparan sulfate C5-epimerase	Drosophila melanogaster	74-79
24133213-1	2013	During the biosynthesis of heparan sulfate (HS), glucuronyl C5-epimerase (Hsepi) catalyzes C5-epimerization of glucuronic acid (GlcA), converting it to iduronic acid (IdoA).	Heparitin Sulfate	44-46	Heparan sulfate C5-epimerase	Drosophila melanogaster	74-79
24278138-3	2013	The syndecan-1 heparan sulfate proteoglycan (HSPG) pathway is important for the hepatic clearance of remnant TRLs in mice, but its relevance in humans is unclear.	Heparitin Sulfate	15-30	syndecan 1	Homo sapiens	4-14
24278138-3	2013	The syndecan-1 heparan sulfate proteoglycan (HSPG) pathway is important for the hepatic clearance of remnant TRLs in mice, but its relevance in humans is unclear.	Heparitin Sulfate	15-30	syndecan 2	Mus musculus	45-49
24260588-3	2013	Using this approach, a series of pseudodisaccharides are synthesised that mimic the repeating backbone unit of heparan sulfate, and are tested for inhibition of heparanase, a disease-relevant enzyme that hydrolyses heparan sulfate.	Heparitin Sulfate	215-230	heparanase	Homo sapiens	161-171
24312095-9	2013	Secondly, studies aiming at characterizing the gp120/HS complex revealed that HS binding was far more complex than previously thought: in addition to the V3 loop of CXCR4 tropic gp120, HS interacts with several other cryptic areas of the protein, which can be induced upon CD4 binding, and are conserved amongst CCR5 and CXCR4 viruses.	Heparitin Sulfate	53-55	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	47-52
24312095-9	2013	Secondly, studies aiming at characterizing the gp120/HS complex revealed that HS binding was far more complex than previously thought: in addition to the V3 loop of CXCR4 tropic gp120, HS interacts with several other cryptic areas of the protein, which can be induced upon CD4 binding, and are conserved amongst CCR5 and CXCR4 viruses.	Heparitin Sulfate	53-55	C-X-C motif chemokine receptor 4	Homo sapiens	165-170
24312095-9	2013	Secondly, studies aiming at characterizing the gp120/HS complex revealed that HS binding was far more complex than previously thought: in addition to the V3 loop of CXCR4 tropic gp120, HS interacts with several other cryptic areas of the protein, which can be induced upon CD4 binding, and are conserved amongst CCR5 and CXCR4 viruses.	Heparitin Sulfate	53-55	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	178-183
24312095-9	2013	Secondly, studies aiming at characterizing the gp120/HS complex revealed that HS binding was far more complex than previously thought: in addition to the V3 loop of CXCR4 tropic gp120, HS interacts with several other cryptic areas of the protein, which can be induced upon CD4 binding, and are conserved amongst CCR5 and CXCR4 viruses.	Heparitin Sulfate	53-55	CD4 molecule	Homo sapiens	273-276
24312095-9	2013	Secondly, studies aiming at characterizing the gp120/HS complex revealed that HS binding was far more complex than previously thought: in addition to the V3 loop of CXCR4 tropic gp120, HS interacts with several other cryptic areas of the protein, which can be induced upon CD4 binding, and are conserved amongst CCR5 and CXCR4 viruses.	Heparitin Sulfate	53-55	C-C motif chemokine receptor 5	Homo sapiens	312-316
24312095-9	2013	Secondly, studies aiming at characterizing the gp120/HS complex revealed that HS binding was far more complex than previously thought: in addition to the V3 loop of CXCR4 tropic gp120, HS interacts with several other cryptic areas of the protein, which can be induced upon CD4 binding, and are conserved amongst CCR5 and CXCR4 viruses.	Heparitin Sulfate	53-55	C-X-C motif chemokine receptor 4	Homo sapiens	321-326
24026183-5	2013	CD44v3-v10 (CD44v3) has heparan sulfate moieties, which enable the binding to HGF/BMP-7, and hence, might exert renoprotective effects.	Heparitin Sulfate	24-39	bone morphogenetic protein 7	Mus musculus	82-87
24035709-0	2013	Structure of the fibrillin-1 N-terminal domains suggests that heparan sulfate regulates the early stages of microfibril assembly.	Heparitin Sulfate	62-77	fibrillin 1	Homo sapiens	17-28
24035513-7	2013	In vitro experiments with perlecan-positive rat mesangial cells showed that FGF2-induced proliferation is dependent on sulfation and can be inhibited by exogenously added heparan sulfate.	Heparitin Sulfate	171-186	fibroblast growth factor 2	Rattus norvegicus	76-80
23895995-3	2013	Heparanase, an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate chains, is upregulated in a variety of human cancers including multiple myeloma.	Heparitin Sulfate	114-129	heparanase	Homo sapiens	0-10
24127555-0	2013	Genome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses.	Heparitin Sulfate	85-100	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	76-83
24127555-0	2013	Genome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses.	Heparitin Sulfate	85-100	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	120-127
24127555-5	2013	KIR2DL4 was found to directly interact with HS/heparin, and the D0 domain of KIR2DL4 was essential for this interaction.	Heparitin Sulfate	44-46	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	0-7
24127555-5	2013	KIR2DL4 was found to directly interact with HS/heparin, and the D0 domain of KIR2DL4 was essential for this interaction.	Heparitin Sulfate	44-46	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	77-84
24127555-6	2013	Accordingly, exogenous HS/heparin can regulate cytokine production by KIR2DL4-expressing NK cells and HEK293T cells (HEK293T-2DL4), and induces differential localization of KIR2DL4 to rab5(+) and rab7(+) endosomes, thus leading to downregulation of cytokine production and degradation of the receptor.	Heparitin Sulfate	23-25	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	70-77
24127555-6	2013	Accordingly, exogenous HS/heparin can regulate cytokine production by KIR2DL4-expressing NK cells and HEK293T cells (HEK293T-2DL4), and induces differential localization of KIR2DL4 to rab5(+) and rab7(+) endosomes, thus leading to downregulation of cytokine production and degradation of the receptor.	Heparitin Sulfate	23-25	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	173-180
24127555-6	2013	Accordingly, exogenous HS/heparin can regulate cytokine production by KIR2DL4-expressing NK cells and HEK293T cells (HEK293T-2DL4), and induces differential localization of KIR2DL4 to rab5(+) and rab7(+) endosomes, thus leading to downregulation of cytokine production and degradation of the receptor.	Heparitin Sulfate	23-25	RAB5A, member RAS oncogene family	Homo sapiens	184-188
24127555-6	2013	Accordingly, exogenous HS/heparin can regulate cytokine production by KIR2DL4-expressing NK cells and HEK293T cells (HEK293T-2DL4), and induces differential localization of KIR2DL4 to rab5(+) and rab7(+) endosomes, thus leading to downregulation of cytokine production and degradation of the receptor.	Heparitin Sulfate	23-25	RAB7B, member RAS oncogene family	Homo sapiens	196-200
24121110-1	2013	Antithrombin III (ATIII) performs a critical anticoagulant function by precluding the activation of blood clotting proteinases, aided by its two cofactors, heparin and heparan sulfate.	Heparitin Sulfate	168-183	serpin family C member 1	Homo sapiens	18-23
23931966-12	2013	The amounts of heparan sulfate were lower during estrus and diestrus and higher in the metestrus phase in HPrl than in Ctr animals.	Heparitin Sulfate	15-30	calcitonin receptor	Mus musculus	119-122
24043886-5	2013	The gp120-TLR interaction also required the presence of heparan sulfate (HS).	Heparitin Sulfate	56-71	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	4-9
24043886-5	2013	The gp120-TLR interaction also required the presence of heparan sulfate (HS).	Heparitin Sulfate	73-75	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	4-9
23467009-3	2013	The ligand for MuSK is LRP4 (low-density lipoprotein receptor-related protein-4), a transmembrane protein in muscle, whose binding affinity for MuSK is potentiated by agrin, a neuronally derived heparan-sulfate proteoglycan.	Heparitin Sulfate	195-210	muscle associated receptor tyrosine kinase	Homo sapiens	15-19
23467009-3	2013	The ligand for MuSK is LRP4 (low-density lipoprotein receptor-related protein-4), a transmembrane protein in muscle, whose binding affinity for MuSK is potentiated by agrin, a neuronally derived heparan-sulfate proteoglycan.	Heparitin Sulfate	195-210	LDL receptor related protein 4	Homo sapiens	23-27
23467009-3	2013	The ligand for MuSK is LRP4 (low-density lipoprotein receptor-related protein-4), a transmembrane protein in muscle, whose binding affinity for MuSK is potentiated by agrin, a neuronally derived heparan-sulfate proteoglycan.	Heparitin Sulfate	195-210	LDL receptor related protein 4	Homo sapiens	29-79
23467009-3	2013	The ligand for MuSK is LRP4 (low-density lipoprotein receptor-related protein-4), a transmembrane protein in muscle, whose binding affinity for MuSK is potentiated by agrin, a neuronally derived heparan-sulfate proteoglycan.	Heparitin Sulfate	195-210	muscle associated receptor tyrosine kinase	Homo sapiens	144-148
23467009-3	2013	The ligand for MuSK is LRP4 (low-density lipoprotein receptor-related protein-4), a transmembrane protein in muscle, whose binding affinity for MuSK is potentiated by agrin, a neuronally derived heparan-sulfate proteoglycan.	Heparitin Sulfate	195-210	agrin	Homo sapiens	167-172
24500561-3	2013	Heparanase is an endoglycosidase that specifically hydrolyzes heparan sulfate into oligosaccharides.	Heparitin Sulfate	62-77	heparanase	Homo sapiens	0-10
24083474-10	2013	HPSE1 enzymatic activity was performed using biotinylated heparan sulfate.	Heparitin Sulfate	58-73	heparanase	Homo sapiens	0-5
24083474-17	2013	Furthermore, our data suggest that high levels of heparan sulfate shed to the medium are able to capture trastuzumab, blocking the antibody action mediated by HER2.	Heparitin Sulfate	50-65	erb-b2 receptor tyrosine kinase 2	Homo sapiens	159-163
23746858-14	2013	Our results indicate that specific ECM substrates that include type IV Collagen, laminin and heparan sulfate support and maintain neuronal and glial differentiation to different extents.	Heparitin Sulfate	93-108	multimerin 1	Homo sapiens	35-38
23851278-0	2013	Fluid shear stress induces the clustering of heparan sulfate via mobility of glypican-1 in lipid rafts.	Heparitin Sulfate	45-60	glypican 1	Homo sapiens	77-87
23884416-1	2013	Heparan sulfate (HS) proteoglycans, present at the plasma membrane of vascular endothelial cells, bind to the angiogenic growth factor VEGFA to modulate its signaling through VEGFR2.	Heparitin Sulfate	0-15	vascular endothelial growth factor A	Homo sapiens	135-140
23884416-1	2013	Heparan sulfate (HS) proteoglycans, present at the plasma membrane of vascular endothelial cells, bind to the angiogenic growth factor VEGFA to modulate its signaling through VEGFR2.	Heparitin Sulfate	0-15	kinase insert domain receptor	Homo sapiens	175-181
23884416-1	2013	Heparan sulfate (HS) proteoglycans, present at the plasma membrane of vascular endothelial cells, bind to the angiogenic growth factor VEGFA to modulate its signaling through VEGFR2.	Heparitin Sulfate	17-19	vascular endothelial growth factor A	Homo sapiens	135-140
23884416-1	2013	Heparan sulfate (HS) proteoglycans, present at the plasma membrane of vascular endothelial cells, bind to the angiogenic growth factor VEGFA to modulate its signaling through VEGFR2.	Heparitin Sulfate	17-19	kinase insert domain receptor	Homo sapiens	175-181
24403231-1	2013	Heparansulfate proteoglycans (HSPG) play an important role in cell-cell and cell-matrix interactions and signaling, and one of the key enzymes in heparansulfate biosynthesis is d-glucuronyl C5-epimerase (GLCE).	Heparitin Sulfate	146-160	glucuronic acid epimerase	Homo sapiens	177-202
24403231-1	2013	Heparansulfate proteoglycans (HSPG) play an important role in cell-cell and cell-matrix interactions and signaling, and one of the key enzymes in heparansulfate biosynthesis is d-glucuronyl C5-epimerase (GLCE).	Heparitin Sulfate	146-160	glucuronic acid epimerase	Homo sapiens	204-208
23748415-1	2013	Mucopolysaccharidosis type IIIA (MPSIIIA) is a lysosomal storage disorder caused by mutations in N-sulfoglucosamine sulfohydrolase (SGSH), resulting in heparan sulfate (HS) accumulation and progressive neurodegeneration.	Heparitin Sulfate	152-167	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	97-130
23748415-1	2013	Mucopolysaccharidosis type IIIA (MPSIIIA) is a lysosomal storage disorder caused by mutations in N-sulfoglucosamine sulfohydrolase (SGSH), resulting in heparan sulfate (HS) accumulation and progressive neurodegeneration.	Heparitin Sulfate	152-167	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	132-136
23748415-1	2013	Mucopolysaccharidosis type IIIA (MPSIIIA) is a lysosomal storage disorder caused by mutations in N-sulfoglucosamine sulfohydrolase (SGSH), resulting in heparan sulfate (HS) accumulation and progressive neurodegeneration.	Heparitin Sulfate	169-171	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	97-130
23748415-1	2013	Mucopolysaccharidosis type IIIA (MPSIIIA) is a lysosomal storage disorder caused by mutations in N-sulfoglucosamine sulfohydrolase (SGSH), resulting in heparan sulfate (HS) accumulation and progressive neurodegeneration.	Heparitin Sulfate	169-171	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	132-136
24052309-4	2013	This results in a partial shutdown of heparan sulfate biosynthesis that impinges on a LON-2/glypican pathway and disrupts neuronal migration.	Heparitin Sulfate	38-53	glypican 1	Homo sapiens	92-100
23911103-2	2013	Here we identify the heparan sulfate (HS) proteoglycan glypican as a receptor for LRRTM4 using an unbiased proteomics-based approach.	Heparitin Sulfate	21-36	glypican 1	Homo sapiens	55-63
23357408-6	2013	The surface-bound glycocalyx glycosaminoglycan constituent heparan sulfate is crucial for CFH binding and function, both in recognition of host tissue and prevention of spontaneous complement activation via the alternative pathway.	Heparitin Sulfate	59-74	complement factor H	Homo sapiens	90-93
23357408-7	2013	Most of the clinically relevant genetic mutations in CFH result in incorrect binding to heparan sulfate.	Heparitin Sulfate	88-103	complement factor H	Homo sapiens	53-56
23911103-2	2013	Here we identify the heparan sulfate (HS) proteoglycan glypican as a receptor for LRRTM4 using an unbiased proteomics-based approach.	Heparitin Sulfate	21-36	leucine rich repeat transmembrane neuronal 4	Homo sapiens	82-88
23911103-2	2013	Here we identify the heparan sulfate (HS) proteoglycan glypican as a receptor for LRRTM4 using an unbiased proteomics-based approach.	Heparitin Sulfate	38-40	glypican 1	Homo sapiens	55-63
23911103-2	2013	Here we identify the heparan sulfate (HS) proteoglycan glypican as a receptor for LRRTM4 using an unbiased proteomics-based approach.	Heparitin Sulfate	38-40	leucine rich repeat transmembrane neuronal 4	Homo sapiens	82-88
23911103-6	2013	LRRTM4 positively regulates excitatory synapse development in cultured neurons and in vivo, and the synaptogenic activity of LRRTM4 requires the presence of HS on the neuronal surface.	Heparitin Sulfate	157-159	leucine rich repeat transmembrane neuronal 4	Homo sapiens	125-131
23951313-10	2013	Recognition of the TFAM-CpGA DNA complex was dependent upon heparin sulfate moieties, and recombinant TFAM Box 1 and Box 2 proteins were equivalent in terms of augmenting TNFalpha release.	Heparitin Sulfate	60-75	transcription factor A, mitochondrial	Mus musculus	19-23
23734945-1	2013	The gene products of two members of the EXT (exostosin) gene family, EXT1 and EXT2, function together as a polymerase in the biosynthesis of heparan sulfate.	Heparitin Sulfate	141-156	exostosin-like glycosyltransferase 3	Mus musculus	40-43
23734945-1	2013	The gene products of two members of the EXT (exostosin) gene family, EXT1 and EXT2, function together as a polymerase in the biosynthesis of heparan sulfate.	Heparitin Sulfate	141-156	exostosin-like glycosyltransferase 3	Mus musculus	45-54
23734945-1	2013	The gene products of two members of the EXT (exostosin) gene family, EXT1 and EXT2, function together as a polymerase in the biosynthesis of heparan sulfate.	Heparitin Sulfate	141-156	exostosin glycosyltransferase 1	Mus musculus	69-73
23734945-1	2013	The gene products of two members of the EXT (exostosin) gene family, EXT1 and EXT2, function together as a polymerase in the biosynthesis of heparan sulfate.	Heparitin Sulfate	141-156	exostosin glycosyltransferase 2	Mus musculus	78-82
23679870-8	2013	These findings indicate that RAGE-heparan sulfate oligomeric complexes are essential for signaling and that interfering with RAGE oligomerization might be of therapeutic value.	Heparitin Sulfate	34-49	advanced glycosylation end-product specific receptor	Homo sapiens	29-33
23696150-6	2013	In contrast, both NDST1 and HS6ST1 showed lower activities at the NRE of heparan sulfate (HS) chains than at the interior of the chain.	Heparitin Sulfate	73-88	N-deacetylase and N-sulfotransferase 1	Homo sapiens	18-23
23696150-6	2013	In contrast, both NDST1 and HS6ST1 showed lower activities at the NRE of heparan sulfate (HS) chains than at the interior of the chain.	Heparitin Sulfate	73-88	heparan sulfate 6-O-sulfotransferase 1	Homo sapiens	28-34
23696150-7	2013	Contrary to the traditional view of HS biosynthesis processes, NDST1 also showed activity on O-sulfated GlcNAc residues.	Heparitin Sulfate	36-38	N-deacetylase and N-sulfotransferase 1	Homo sapiens	63-68
23863627-3	2013	Mucopolysaccharidosis type IIIA (MPS IIIA) is an autosomic recessive LSD caused by a deficiency in sulfamidase, a sulfatase involved in the stepwise degradation of glycosaminoglycan (GAG) heparan sulfate.	Heparitin Sulfate	188-203	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-31
23744737-0	2013	Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/beta-catenin signaling.	Heparitin Sulfate	0-15	catenin (cadherin associated protein), beta 1	Mus musculus	109-121
23682123-6	2013	Absence of the heparan sulfate-binding VEGF isoforms, VEGF164 and VEGF188, resulted in abnormal BAT development in mice at E15.5, with fewer brown adipocytes and lower mitochondrial protein compared to wild-type littermates.	Heparitin Sulfate	15-30	vascular endothelial growth factor A	Mus musculus	39-43
23771188-3	2013	While factors for severity remain unknown, mutations in exostosin 1 and exostosin 2 genes, encoding glycosyltransferases involved in the biosynthesis of ubiquitously expressed heparan sulphate (HS) chains, are associated with MHE.	Heparitin Sulfate	176-192	exostosin glycosyltransferase 1	Mus musculus	56-67
23771188-3	2013	While factors for severity remain unknown, mutations in exostosin 1 and exostosin 2 genes, encoding glycosyltransferases involved in the biosynthesis of ubiquitously expressed heparan sulphate (HS) chains, are associated with MHE.	Heparitin Sulfate	176-192	exostosin glycosyltransferase 2	Mus musculus	72-83
23771188-3	2013	While factors for severity remain unknown, mutations in exostosin 1 and exostosin 2 genes, encoding glycosyltransferases involved in the biosynthesis of ubiquitously expressed heparan sulphate (HS) chains, are associated with MHE.	Heparitin Sulfate	194-196	exostosin glycosyltransferase 1	Mus musculus	56-67
23771188-3	2013	While factors for severity remain unknown, mutations in exostosin 1 and exostosin 2 genes, encoding glycosyltransferases involved in the biosynthesis of ubiquitously expressed heparan sulphate (HS) chains, are associated with MHE.	Heparitin Sulfate	194-196	exostosin glycosyltransferase 2	Mus musculus	72-83
23822587-3	2013	The results suggest that multiple adhesamine molecules cooperatively bind to heparan sulfate and induce its assembly, promoting clustering of heparan sulfate-bound syndecan-4 on the cell surface.	Heparitin Sulfate	77-92	syndecan 4	Homo sapiens	164-174
23822587-3	2013	The results suggest that multiple adhesamine molecules cooperatively bind to heparan sulfate and induce its assembly, promoting clustering of heparan sulfate-bound syndecan-4 on the cell surface.	Heparitin Sulfate	142-157	syndecan 4	Homo sapiens	164-174
23679870-0	2013	Stable RAGE-heparan sulfate complexes are essential for signal transduction.	Heparitin Sulfate	12-27	advanced glycosylation end-product specific receptor	Homo sapiens	7-11
23679870-4	2013	Here we report that RAGE activation of Erk1/2 phosphorylation on endothelial cells in response to a number of ligands depends on a mechanism that involves heparan sulfate-induced hexamerization of the RAGE extracellular domain.	Heparitin Sulfate	155-170	advanced glycosylation end-product specific receptor	Homo sapiens	20-24
23679870-4	2013	Here we report that RAGE activation of Erk1/2 phosphorylation on endothelial cells in response to a number of ligands depends on a mechanism that involves heparan sulfate-induced hexamerization of the RAGE extracellular domain.	Heparitin Sulfate	155-170	mitogen-activated protein kinase 3	Homo sapiens	39-45
23679870-8	2013	These findings indicate that RAGE-heparan sulfate oligomeric complexes are essential for signaling and that interfering with RAGE oligomerization might be of therapeutic value.	Heparitin Sulfate	34-49	advanced glycosylation end-product specific receptor	Homo sapiens	125-129
23679870-4	2013	Here we report that RAGE activation of Erk1/2 phosphorylation on endothelial cells in response to a number of ligands depends on a mechanism that involves heparan sulfate-induced hexamerization of the RAGE extracellular domain.	Heparitin Sulfate	155-170	advanced glycosylation end-product specific receptor	Homo sapiens	201-205
23760952-10	2013	This could be mediated via heparan sulfate residues, as Vangl2(Lp/+) embryos fail to initiate neural tube closure and develop craniorachischisis (usually seen only in Vangl2(Lp/Lp)) when cultured in the presence of chlorate, a sulfation inhibitor.	Heparitin Sulfate	27-42	VANGL planar cell polarity protein 2	Homo sapiens	56-62
23632323-2	2013	Here we present a therapeutic strategy to harness the activity of endogenously produced BMP-2 by delivery of an affinity-matched heparan sulfate (HS) glycos aminoglycan biomaterial that increases the bioavailability, bioactivity and half-life of this growth factor.	Heparitin Sulfate	129-144	bone morphogenetic protein 2	Oryctolagus cuniculus	88-93
23632323-2	2013	Here we present a therapeutic strategy to harness the activity of endogenously produced BMP-2 by delivery of an affinity-matched heparan sulfate (HS) glycos aminoglycan biomaterial that increases the bioavailability, bioactivity and half-life of this growth factor.	Heparitin Sulfate	146-149	bone morphogenetic protein 2	Oryctolagus cuniculus	88-93
23514715-1	2013	Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder with wide variation in clinical phenotype and is caused by heterogeneous germline mutations in two of the Ext genes, EXT-1 and EXT-2, which encode ubiquitously expressed glycosyltransferases involved in the polymerization of heparan sulfate (HS) chains.	Heparitin Sulfate	304-319	exostosin glycosyltransferase 1	Homo sapiens	196-201
23514715-1	2013	Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder with wide variation in clinical phenotype and is caused by heterogeneous germline mutations in two of the Ext genes, EXT-1 and EXT-2, which encode ubiquitously expressed glycosyltransferases involved in the polymerization of heparan sulfate (HS) chains.	Heparitin Sulfate	304-319	exostosin glycosyltransferase 2	Homo sapiens	206-211
23844141-2	2013	ApoE mediates HCV attachment by binding to the cell surface heparan sulfate (HS) which is covalently attached to the core proteins of proteoglycans (HSPGs).	Heparitin Sulfate	60-75	apolipoprotein E	Homo sapiens	0-4
23844141-2	2013	ApoE mediates HCV attachment by binding to the cell surface heparan sulfate (HS) which is covalently attached to the core proteins of proteoglycans (HSPGs).	Heparitin Sulfate	77-79	apolipoprotein E	Homo sapiens	0-4
23514715-1	2013	Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder with wide variation in clinical phenotype and is caused by heterogeneous germline mutations in two of the Ext genes, EXT-1 and EXT-2, which encode ubiquitously expressed glycosyltransferases involved in the polymerization of heparan sulfate (HS) chains.	Heparitin Sulfate	321-323	exostosin glycosyltransferase 1	Homo sapiens	196-201
23514715-1	2013	Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder with wide variation in clinical phenotype and is caused by heterogeneous germline mutations in two of the Ext genes, EXT-1 and EXT-2, which encode ubiquitously expressed glycosyltransferases involved in the polymerization of heparan sulfate (HS) chains.	Heparitin Sulfate	321-323	exostosin glycosyltransferase 2	Homo sapiens	206-211
23740953-0	2013	Amino acid copolymers that alleviate experimental autoimmune encephalomyelitis in vivo interact with heparan sulfates and glycoprotein 96 in APCs.	Heparitin Sulfate	101-117	amyloid P component, serum	Mus musculus	141-145
23664118-7	2013	A strong reduction in heparan sulfate level was also observed, indicating that beta3GalT6 deficiency alters synthesis of both main types of glycosaminoglycans.	Heparitin Sulfate	22-37	beta-1,3-galactosyltransferase 6	Homo sapiens	79-89
23792691-6	2013	By screening for TRF2-bound genes, we found that HS3ST4--a gene encoding for the heparan sulphate (glucosamine) 3-O-sulphotransferase 4--was regulated by TRF2 and inhibited the recruitment of NK cells in an epistatic relationship with TRF2.	Heparitin Sulfate	81-97	telomeric repeat binding factor 2	Homo sapiens	17-21
23792691-6	2013	By screening for TRF2-bound genes, we found that HS3ST4--a gene encoding for the heparan sulphate (glucosamine) 3-O-sulphotransferase 4--was regulated by TRF2 and inhibited the recruitment of NK cells in an epistatic relationship with TRF2.	Heparitin Sulfate	81-97	heparan sulfate-glucosamine 3-sulfotransferase 4	Homo sapiens	49-55
23792691-6	2013	By screening for TRF2-bound genes, we found that HS3ST4--a gene encoding for the heparan sulphate (glucosamine) 3-O-sulphotransferase 4--was regulated by TRF2 and inhibited the recruitment of NK cells in an epistatic relationship with TRF2.	Heparitin Sulfate	81-97	telomeric repeat binding factor 2	Homo sapiens	154-158
23792691-6	2013	By screening for TRF2-bound genes, we found that HS3ST4--a gene encoding for the heparan sulphate (glucosamine) 3-O-sulphotransferase 4--was regulated by TRF2 and inhibited the recruitment of NK cells in an epistatic relationship with TRF2.	Heparitin Sulfate	81-97	telomeric repeat binding factor 2	Homo sapiens	154-158
23734709-0	2013	Insights into the mechanism by which interferon-gamma basic amino acid clusters mediate protein binding to heparan sulfate.	Heparitin Sulfate	107-122	interferon gamma	Homo sapiens	37-53
23499527-1	2013	Heparanase (Hpse) is an endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS) in basement membranes (BMs) to facilitate leukocyte migration into tissues.	Heparitin Sulfate	86-101	heparanase	Homo sapiens	0-10
23499527-1	2013	Heparanase (Hpse) is an endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS) in basement membranes (BMs) to facilitate leukocyte migration into tissues.	Heparitin Sulfate	86-101	heparanase	Homo sapiens	12-16
23499527-1	2013	Heparanase (Hpse) is an endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS) in basement membranes (BMs) to facilitate leukocyte migration into tissues.	Heparitin Sulfate	86-101	glucuronidase beta	Homo sapiens	29-49
23499527-1	2013	Heparanase (Hpse) is an endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS) in basement membranes (BMs) to facilitate leukocyte migration into tissues.	Heparitin Sulfate	103-105	heparanase	Homo sapiens	0-10
23499527-1	2013	Heparanase (Hpse) is an endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS) in basement membranes (BMs) to facilitate leukocyte migration into tissues.	Heparitin Sulfate	103-105	heparanase	Homo sapiens	12-16
23499527-1	2013	Heparanase (Hpse) is an endo-beta-d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS) in basement membranes (BMs) to facilitate leukocyte migration into tissues.	Heparitin Sulfate	103-105	glucuronidase beta	Homo sapiens	29-49
23499527-3	2013	In disease states, the degradation of HS in BMs by heparanase is well recognized as an invasive property of metastatic cancer cells.	Heparitin Sulfate	38-40	heparanase	Homo sapiens	51-61
23499529-4	2013	Heparanase is an enzyme that cleaves heparan sulfate polysaccharide into smaller fragments, regulating the functions of heparan sulfate.	Heparitin Sulfate	37-52	heparanase	Homo sapiens	0-10
23499529-6	2013	The prevailing view is that heparanase recognizes specific sulfation patterns in heparan sulfate.	Heparitin Sulfate	81-96	heparanase	Homo sapiens	28-38
23499529-8	2013	The plastic substrate specificity suggests a complex role of heparanase in regulating the structures of heparan sulfate in matrix biology.	Heparitin Sulfate	104-119	heparanase	Homo sapiens	61-71
23499530-1	2013	Heparanase, the sole mammalian endoglycosidase degrading heparan sulfate, is causally involved in cancer metastasis, angiogenesis, inflammation and kidney dysfunction.	Heparitin Sulfate	57-72	heparanase	Homo sapiens	0-10
23734081-5	2013	The effect of the vitreal HS level on the binding of exogenous VEGF to surface-bound heparin was determined in vitro.	Heparitin Sulfate	26-28	vascular endothelial growth factor A	Homo sapiens	63-67
23667176-11	2013	Thus, direct binding experiments, dependence on heparan sulfate, and the presence of a NRP1 consensus binding sequence indicate that NRP1 is the binding site of LD22-4 and mediates inhibition of cell migration.	Heparitin Sulfate	48-63	neuropilin 1	Homo sapiens	133-137
23837057-1	2013	Heparanase (HPSE) is a type of endoglycosidase that decomposes the heparan sulfate (HS) lateral chains of heparan sulfate proteoglycans (HSPGs), releases related growth factors and participates in angiogenesis and bone formation.	Heparitin Sulfate	67-82	heparanase	Rattus norvegicus	0-10
23837057-1	2013	Heparanase (HPSE) is a type of endoglycosidase that decomposes the heparan sulfate (HS) lateral chains of heparan sulfate proteoglycans (HSPGs), releases related growth factors and participates in angiogenesis and bone formation.	Heparitin Sulfate	67-82	heparanase	Rattus norvegicus	12-16
23837057-1	2013	Heparanase (HPSE) is a type of endoglycosidase that decomposes the heparan sulfate (HS) lateral chains of heparan sulfate proteoglycans (HSPGs), releases related growth factors and participates in angiogenesis and bone formation.	Heparitin Sulfate	84-86	heparanase	Rattus norvegicus	0-10
23837057-1	2013	Heparanase (HPSE) is a type of endoglycosidase that decomposes the heparan sulfate (HS) lateral chains of heparan sulfate proteoglycans (HSPGs), releases related growth factors and participates in angiogenesis and bone formation.	Heparitin Sulfate	84-86	heparanase	Rattus norvegicus	12-16
23418199-1	2013	Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-beta1 (TGF-beta1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-beta1 and that TGF-beta1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.	Heparitin Sulfate	31-46	sulfatase 1	Homo sapiens	73-78
23418199-1	2013	Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-beta1 (TGF-beta1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-beta1 and that TGF-beta1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.	Heparitin Sulfate	31-46	transforming growth factor beta 1	Homo sapiens	85-117
23418199-1	2013	Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-beta1 (TGF-beta1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-beta1 and that TGF-beta1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.	Heparitin Sulfate	31-46	transforming growth factor beta 1	Homo sapiens	119-128
23418199-1	2013	Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-beta1 (TGF-beta1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-beta1 and that TGF-beta1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.	Heparitin Sulfate	31-46	transforming growth factor beta 1	Homo sapiens	229-238
23418199-1	2013	Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-beta1 (TGF-beta1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-beta1 and that TGF-beta1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.	Heparitin Sulfate	31-46	transforming growth factor beta 1	Homo sapiens	229-238
23418199-1	2013	Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-beta1 (TGF-beta1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-beta1 and that TGF-beta1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.	Heparitin Sulfate	31-46	sulfatase 1	Homo sapiens	284-289
23418199-1	2013	Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-beta1 (TGF-beta1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-beta1 and that TGF-beta1 induces the expression of Sulf1 as well as that of the closely related Sulf2 in a murine model of pulmonary fibrosis.	Heparitin Sulfate	31-46	sulfatase 2	Homo sapiens	329-334
23676495-3	2013	Evidence supporting ApoE as a major determinant arose from its enrichment in TRLs from mice defective in hepatic heparan sulfate (Ndst1f/fAlbCre+ mice), decreased binding of ApoE-deficient TRLs to HSPGs on human hepatoma cells, and decreased clearance of ApoE-deficient [3H]TRLs in vivo.	Heparitin Sulfate	113-128	apolipoprotein E	Mus musculus	20-24
23676495-5	2013	ApoAV emerged as a candidate based on 6-fold enrichment of ApoAV in TRLs accumulating in Ndst1f/fAlbCre+ mice, decreased binding of TRLs to proteoglycans after depletion of ApoAV or addition of anti-ApoAV mAb, and decreased heparan sulfate-dependent binding of ApoAV-deficient particles to hepatocytes.	Heparitin Sulfate	224-239	apolipoprotein A-V	Mus musculus	0-5
23571852-10	2013	The pro-tumourigenic contribution of the heparin/HS interactomes was verified in cells in which HSPG synthesis was blocked using beta-xyloside.	Heparitin Sulfate	49-51	syndecan 2	Homo sapiens	96-100
23734081-10	2013	The increasing level of HS or sulfated glycosaminoglycan in the vitreous was associated with its increased inhibitory effect on interaction between VEGF and surface heparin in vitro (p=0.014, R2=0.377).	Heparitin Sulfate	24-26	vascular endothelial growth factor A	Homo sapiens	148-152
23471235-7	2013	Of the 2 forms of heparanase secreted from EC in response to high glucose, active heparanase released LPL from the myocyte surface, whereas latent heparanase stimulated reloading of LPL from an intracellular pool via heparan sulfate proteoglycan-mediated RhoA activation.	Heparitin Sulfate	217-232	lipoprotein lipase	Homo sapiens	182-185
23667853-1	2013	Mucopolysaccharidosis (MPS) IIIB is a lysosomal storage disorder (LSD) caused by abnormalities of the enzyme alpha-N-acetylglucosaminidase (NAGLU) that is required for degradation of heparan sulfate.	Heparitin Sulfate	183-198	N-acetyl-alpha-glucosaminidase	Homo sapiens	109-138
23667853-1	2013	Mucopolysaccharidosis (MPS) IIIB is a lysosomal storage disorder (LSD) caused by abnormalities of the enzyme alpha-N-acetylglucosaminidase (NAGLU) that is required for degradation of heparan sulfate.	Heparitin Sulfate	183-198	N-acetyl-alpha-glucosaminidase	Homo sapiens	140-145
23458899-8	2013	Interference with HS function reduced the physical association and interactions of BMP2 with HS and increased the cell responsiveness to endogenous and exogenous BMP proteins.	Heparitin Sulfate	18-20	bone morphogenetic protein 2	Mus musculus	83-87
23274385-0	2013	Mild mental retardation and low levels of urinary heparan sulfate in a patient with the attenuated phenotype of mucopolysaccharidosis type IIIA.	Heparitin Sulfate	50-65	N-sulfoglucosamine sulfohydrolase	Homo sapiens	112-143
23274385-1	2013	OBJECTIVES: We report the case of a 28-year-old female subject affected by the attenuated phenotype of mucopolysaccharidosis type IIIA characterized by moderate slowly evolving mental retardation in which the urinary content of heparan sulfate was demonstrated as being substantially low compared to that found in patients with the severe phenotype.	Heparitin Sulfate	228-243	N-sulfoglucosamine sulfohydrolase	Homo sapiens	103-134
23360476-6	2013	RAGE strongly interacted with not only CS-E but also heparan sulfate in vitro.	Heparitin Sulfate	53-68	advanced glycosylation end product-specific receptor	Mus musculus	0-4
23374111-9	2013	Overexpression of syndecan-4 with mutated enzyme-interacting domains suggested enzyme-dependent heparan sulfate chains to regulate shedding.	Heparitin Sulfate	96-111	syndecan 4	Homo sapiens	18-28
23520217-14	2013	CONCLUSION: This study illustrates the feasibility of using radiolabeled rECP for the visualization of HS side chains of HSPGs and the evaluation of allergic lung inflammation in living subjects.	Heparitin Sulfate	103-105	ribonuclease A family member 3	Rattus norvegicus	73-77
23398975-2	2013	Heparanase is the sole mammalian endoglycosidase that cleaves heparan sulfate.	Heparitin Sulfate	62-77	heparanase	Homo sapiens	0-10
23161284-0	2013	CXCL14 enhances proliferation and migration of NCI-H460 human lung cancer cells overexpressing the glycoproteins containing heparan sulfate or sialic acid.	Heparitin Sulfate	124-139	C-X-C motif chemokine ligand 14	Homo sapiens	0-6
23569252-5	2013	DEK internalization is a heparan sulfate-dependent process, and cellular uptake of DEK into DEK knockdown cells corrects global heterochromatin depletion and DNA repair deficits, the phenotypic aberrations characteristic of these cells.	Heparitin Sulfate	25-40	DEK proto-oncogene	Homo sapiens	0-3
23357641-4	2013	Nephronectin bound strongly to heparin and chondroitin sulfate (CS)-E and moderately to heparan sulfate (HS), but failed to bind to CS-A, CS-C, CS-D, dermatan sulfate and hyaluronic acid.	Heparitin Sulfate	88-103	nephronectin	Mus musculus	0-12
23357641-4	2013	Nephronectin bound strongly to heparin and chondroitin sulfate (CS)-E and moderately to heparan sulfate (HS), but failed to bind to CS-A, CS-C, CS-D, dermatan sulfate and hyaluronic acid.	Heparitin Sulfate	105-107	nephronectin	Mus musculus	0-12
23569252-5	2013	DEK internalization is a heparan sulfate-dependent process, and cellular uptake of DEK into DEK knockdown cells corrects global heterochromatin depletion and DNA repair deficits, the phenotypic aberrations characteristic of these cells.	Heparitin Sulfate	25-40	DEK proto-oncogene	Homo sapiens	83-86
23569252-5	2013	DEK internalization is a heparan sulfate-dependent process, and cellular uptake of DEK into DEK knockdown cells corrects global heterochromatin depletion and DNA repair deficits, the phenotypic aberrations characteristic of these cells.	Heparitin Sulfate	25-40	DEK proto-oncogene	Homo sapiens	83-86
23593225-5	2013	Idua encodes alpha-L-iduronidase, an enzyme required for degradation of the glycosaminoglycans (GAGs) heparan sulfate and dermatan sulfate.	Heparitin Sulfate	102-117	iduronidase, alpha-L	Mus musculus	0-4
23601319-3	2013	Heparin fragments of defined length are used as chemical analogs of the sulfated domains of heparan sulfate and examined for their ability to oligomerize FGF1.	Heparitin Sulfate	92-107	fibroblast growth factor 1	Homo sapiens	154-158
23593225-5	2013	Idua encodes alpha-L-iduronidase, an enzyme required for degradation of the glycosaminoglycans (GAGs) heparan sulfate and dermatan sulfate.	Heparitin Sulfate	102-117	iduronidase, alpha-L	Mus musculus	13-32
23510468-2	2013	We have previously shown that heparan sulphates (HS) associated with fractones bind fibroblast growth factor-2 (FGF-2), a powerful mitotic growth factor in the SVZa.	Heparitin Sulfate	30-47	fibroblast growth factor 2	Homo sapiens	84-110
23510468-2	2013	We have previously shown that heparan sulphates (HS) associated with fractones bind fibroblast growth factor-2 (FGF-2), a powerful mitotic growth factor in the SVZa.	Heparitin Sulfate	30-47	fibroblast growth factor 2	Homo sapiens	112-117
23510468-2	2013	We have previously shown that heparan sulphates (HS) associated with fractones bind fibroblast growth factor-2 (FGF-2), a powerful mitotic growth factor in the SVZa.	Heparitin Sulfate	49-51	fibroblast growth factor 2	Homo sapiens	84-110
23510468-2	2013	We have previously shown that heparan sulphates (HS) associated with fractones bind fibroblast growth factor-2 (FGF-2), a powerful mitotic growth factor in the SVZa.	Heparitin Sulfate	49-51	fibroblast growth factor 2	Homo sapiens	112-117
23313782-1	2013	INTRODUCTION: Heparanase, the sole heparan sulfate degrading enzyme, has a role in cellular invasion.	Heparitin Sulfate	35-50	heparanase	Homo sapiens	14-24
22886070-1	2013	Recently, we demonstrated that the human xylosyltransferase II (XT-II) has enzymatic activity and is able to catalyze the initial and rate-limiting step in the biosynthesis of glycosaminoglycans (GAGs) like chondroitin and dermatan sulfate, as well as heparan sulfate and heparin.	Heparitin Sulfate	252-267	xylosyltransferase 2	Homo sapiens	41-62
22886070-1	2013	Recently, we demonstrated that the human xylosyltransferase II (XT-II) has enzymatic activity and is able to catalyze the initial and rate-limiting step in the biosynthesis of glycosaminoglycans (GAGs) like chondroitin and dermatan sulfate, as well as heparan sulfate and heparin.	Heparitin Sulfate	252-267	xylosyltransferase 2	Homo sapiens	64-69
23192429-3	2013	Rejecting renal allograft biopsy tissues showed increased expression of the latent TGF-beta complex, which was localized around the tubules by a mechanism that might involve interaction with heparan sulfate in the basement membrane.	Heparitin Sulfate	191-206	transforming growth factor beta 1	Homo sapiens	83-91
23192429-8	2013	This study suggests that penetration of renal tubules by activated T cells leads to increased expression of T cell-surface TSP-1, allowing activation of latent TGF-beta sequestered on heparan sulfate within the microenvironment.	Heparitin Sulfate	184-199	thrombospondin 1	Homo sapiens	123-128
23192429-8	2013	This study suggests that penetration of renal tubules by activated T cells leads to increased expression of T cell-surface TSP-1, allowing activation of latent TGF-beta sequestered on heparan sulfate within the microenvironment.	Heparitin Sulfate	184-199	transforming growth factor beta 1	Homo sapiens	160-168
23376160-5	2013	Egfr signaling in ICs limits the number of cells that express the heparan sulfate proteoglycan Dally, which is required for the movement and stability of the locally-produced stromal morphogen, Decapentaplegic (Dpp, a BMP2/4 homologue).	Heparitin Sulfate	66-81	Epidermal growth factor receptor	Drosophila melanogaster	0-4
23376160-5	2013	Egfr signaling in ICs limits the number of cells that express the heparan sulfate proteoglycan Dally, which is required for the movement and stability of the locally-produced stromal morphogen, Decapentaplegic (Dpp, a BMP2/4 homologue).	Heparitin Sulfate	66-81	division abnormally delayed	Drosophila melanogaster	95-100
23376160-5	2013	Egfr signaling in ICs limits the number of cells that express the heparan sulfate proteoglycan Dally, which is required for the movement and stability of the locally-produced stromal morphogen, Decapentaplegic (Dpp, a BMP2/4 homologue).	Heparitin Sulfate	66-81	decapentaplegic	Drosophila melanogaster	194-209
23376160-5	2013	Egfr signaling in ICs limits the number of cells that express the heparan sulfate proteoglycan Dally, which is required for the movement and stability of the locally-produced stromal morphogen, Decapentaplegic (Dpp, a BMP2/4 homologue).	Heparitin Sulfate	66-81	decapentaplegic	Drosophila melanogaster	211-214
23313126-8	2013	Luciferase assay also showed that Dally promotes JAK/STAT signaling activity, and is dependent on its heparin sulfate chains.	Heparitin Sulfate	102-117	division abnormally delayed	Drosophila melanogaster	34-39
23241438-1	2013	Heparanase is a mammalian endoglycosidase that degrades heparan sulfate at the cell surface and in the extracellular matrix.	Heparitin Sulfate	56-71	heparanase	Homo sapiens	0-10
23395820-1	2013	Mutant alleles of EXT1 or EXT2, two members of the EXT gene family, are causative agents in hereditary multiple exostoses, and their gene products function together as a polymerase in the biosynthesis of heparan sulfate.	Heparitin Sulfate	204-219	exostosin glycosyltransferase 1	Mus musculus	18-22
23395820-1	2013	Mutant alleles of EXT1 or EXT2, two members of the EXT gene family, are causative agents in hereditary multiple exostoses, and their gene products function together as a polymerase in the biosynthesis of heparan sulfate.	Heparitin Sulfate	204-219	exostosin glycosyltransferase 2	Mus musculus	26-30
23997646-8	2013	We also describe how the genetic approach in C. elegans has allowed the discovery of the genes involved in KAL1-heparan sulfate proteoglycans interactions and the identification of HS6ST1 as a new disease gene.	Heparitin Sulfate	112-127	uncharacterized protein	Caenorhabditis elegans	107-111
23313126-8	2013	Luciferase assay also showed that Dally promotes JAK/STAT signaling activity, and is dependent on its heparin sulfate chains.	Heparitin Sulfate	102-117	hopscotch	Drosophila melanogaster	49-52
23313126-8	2013	Luciferase assay also showed that Dally promotes JAK/STAT signaling activity, and is dependent on its heparin sulfate chains.	Heparitin Sulfate	102-117	Signal-transducer and activator of transcription protein at 92E	Drosophila melanogaster	53-57
23357298-5	2013	Treatment of HRPE cells with TGF-beta enhanced secretion of anosmin-1 and the release of anosmin-1 was further augmented by heparin sulfate.	Heparitin Sulfate	124-139	transforming growth factor beta 1	Homo sapiens	29-37
23357298-5	2013	Treatment of HRPE cells with TGF-beta enhanced secretion of anosmin-1 and the release of anosmin-1 was further augmented by heparin sulfate.	Heparitin Sulfate	124-139	anosmin 1	Homo sapiens	89-98
23002246-3	2013	Here, we tested the hypothesis that matrix-associated heparan sulfate is enough to maintain hES cells under low fibroblast growth factor-2 concentration in the absence of live feeder cells.	Heparitin Sulfate	54-69	fibroblast growth factor 2	Homo sapiens	112-138
23325889-4	2013	Use of blocking Abs and degradative enzymes demonstrated that CXCL8-stimulated filopodia formation was mediated by CXCR1 and CXCR2, Duffy Ag/receptor for chemokines, heparan sulfate (HS), and syndecans.	Heparitin Sulfate	166-181	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
23451335-0	2013	Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans.	Heparitin Sulfate	22-37	uncharacterized protein	Caenorhabditis elegans	77-82
23333331-1	2013	The cell surface heparan sulfate proteoglycan, syndecan-2, is known to play an important role in the tumorigenic activity of colon cancer cells, but the function of its extracellular domain is not yet clear.	Heparitin Sulfate	17-32	syndecan 2	Homo sapiens	47-57
23365078-2	2013	These polyanions include heparan sulfate (HS), a glycosaminoglycan with a highly diverse range of structures, for which two regions of CFH (CCP6-8 and CCP19-20) have been implicated in HS binding.	Heparitin Sulfate	25-40	complement factor H	Homo sapiens	135-138
23365078-2	2013	These polyanions include heparan sulfate (HS), a glycosaminoglycan with a highly diverse range of structures, for which two regions of CFH (CCP6-8 and CCP19-20) have been implicated in HS binding.	Heparitin Sulfate	25-40	AGBL carboxypeptidase 4	Homo sapiens	140-146
23365078-2	2013	These polyanions include heparan sulfate (HS), a glycosaminoglycan with a highly diverse range of structures, for which two regions of CFH (CCP6-8 and CCP19-20) have been implicated in HS binding.	Heparitin Sulfate	185-187	complement factor H	Homo sapiens	135-138
23365078-2	2013	These polyanions include heparan sulfate (HS), a glycosaminoglycan with a highly diverse range of structures, for which two regions of CFH (CCP6-8 and CCP19-20) have been implicated in HS binding.	Heparitin Sulfate	185-187	AGBL carboxypeptidase 4	Homo sapiens	140-146
23365078-5	2013	Our data show that the CCP6-8 region of CFH binds more strongly to heparin (a highly sulfated form of HS) than CCP19-20, and that their sulfate specificities are different.	Heparitin Sulfate	102-104	AGBL carboxypeptidase 4	Homo sapiens	23-29
23365078-5	2013	Our data show that the CCP6-8 region of CFH binds more strongly to heparin (a highly sulfated form of HS) than CCP19-20, and that their sulfate specificities are different.	Heparitin Sulfate	102-104	complement factor H	Homo sapiens	40-43
23325889-4	2013	Use of blocking Abs and degradative enzymes demonstrated that CXCL8-stimulated filopodia formation was mediated by CXCR1 and CXCR2, Duffy Ag/receptor for chemokines, heparan sulfate (HS), and syndecans.	Heparitin Sulfate	183-185	C-X-C motif chemokine ligand 8	Homo sapiens	62-67
23325889-5	2013	HS was present on filopodial protrusions appearing as a meshwork on the cell surface, which colocalized with CXCL8, and this glycosaminoglycan was 2,6-O- and 3-O-sulfated.	Heparitin Sulfate	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
23325889-6	2013	Transmission electron microscopy revealed that CXCL8-stimulated filopodial and microvilli-like protrusions that interacted with leukocytes before transendothelial migration and removal of HS reduced this migration.	Heparitin Sulfate	188-190	C-X-C motif chemokine ligand 8	Homo sapiens	47-52
23327652-10	2013	HS synthesis was affected by lower levels of some 3-O-sulfotransferase transcripts, the expression of NDST4 and, only in non metastatic tumors, higher levels of extracellular sulfatases.	Heparitin Sulfate	0-2	N-deacetylase and N-sulfotransferase 4	Homo sapiens	102-107
23300081-0	2013	Drosophila heparan sulfate 6-O-endosulfatase Sulf1 facilitates wingless (Wg) protein degradation.	Heparitin Sulfate	11-26	Sulfated	Drosophila melanogaster	45-50
22956273-2	2013	Early studies on the ligands of PTPsigma identified heparan sulfate proteolycan (HSPG) as a ligand.	Heparitin Sulfate	52-67	protein tyrosine phosphatase receptor type S	Homo sapiens	32-40
22956273-2	2013	Early studies on the ligands of PTPsigma identified heparan sulfate proteolycan (HSPG) as a ligand.	Heparitin Sulfate	52-67	syndecan 2	Homo sapiens	81-85
23232116-9	2013	Furthermore, during the induction, we observed increased expression of 3-O sulfated heparan sulfate (HS) structures synthesized by HS 3-O-sulfotransferase (3OST), which are recognized by the HS4C3 antibody (HS4C3-binding epitope).	Heparitin Sulfate	84-99	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	Mus musculus	134-154
23232116-9	2013	Furthermore, during the induction, we observed increased expression of 3-O sulfated heparan sulfate (HS) structures synthesized by HS 3-O-sulfotransferase (3OST), which are recognized by the HS4C3 antibody (HS4C3-binding epitope).	Heparitin Sulfate	84-99	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	Mus musculus	156-160
23232116-9	2013	Furthermore, during the induction, we observed increased expression of 3-O sulfated heparan sulfate (HS) structures synthesized by HS 3-O-sulfotransferase (3OST), which are recognized by the HS4C3 antibody (HS4C3-binding epitope).	Heparitin Sulfate	101-103	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	Mus musculus	134-154
23232116-9	2013	Furthermore, during the induction, we observed increased expression of 3-O sulfated heparan sulfate (HS) structures synthesized by HS 3-O-sulfotransferase (3OST), which are recognized by the HS4C3 antibody (HS4C3-binding epitope).	Heparitin Sulfate	101-103	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	Mus musculus	156-160
23190312-6	2013	An age-associated decline in the migratory response of OECs toward a gradient of VEGF significantly correlated with a reduction in the relative percentage of the trisulfated disaccharide, 2-O-sulfated-uronic acid, N, 6-O-sulfated-glucosamine (UA[2S]-GlcNS[6S]), within OEC cell surface HS polysaccharide chains.	Heparitin Sulfate	286-288	vascular endothelial growth factor A	Homo sapiens	81-85
23114962-8	2013	Furthermore, expression of a heparan sulfate proteoglycan, syndecan-1, is also differentially regulated by the two waveforms, and its suppression mutes the atheroprotective flow-induced cell surface expression of heparan sulfate.	Heparitin Sulfate	29-44	syndecan 1	Homo sapiens	59-69
23166320-8	2013	Competition experiments demonstrated that free heparin and heparan sulfate (HS), but not selectively 2-O-, 6-O-, and N-O desulfated heparins, prevent p17 binding to substrate-immobilized heparin, indicating that the sulfate groups of the glycosaminoglycan mediate p17 interaction.	Heparitin Sulfate	59-74	family with sequence similarity 72 member B	Homo sapiens	150-153
23083208-1	2013	The 3-O-sulfation of N-sulfated glucosamine is the last event in the biosynthesis of heparin/heparan sulfate, giving rise to the antithrombin-binding pentasaccharide sequence AGA*IA, which is largely associated with the antithrombotic activity of these molecules.	Heparitin Sulfate	93-108	serpin family C member 1	Homo sapiens	129-141
23166320-8	2013	Competition experiments demonstrated that free heparin and heparan sulfate (HS), but not selectively 2-O-, 6-O-, and N-O desulfated heparins, prevent p17 binding to substrate-immobilized heparin, indicating that the sulfate groups of the glycosaminoglycan mediate p17 interaction.	Heparitin Sulfate	59-74	family with sequence similarity 72 member B	Homo sapiens	264-267
23166320-8	2013	Competition experiments demonstrated that free heparin and heparan sulfate (HS), but not selectively 2-O-, 6-O-, and N-O desulfated heparins, prevent p17 binding to substrate-immobilized heparin, indicating that the sulfate groups of the glycosaminoglycan mediate p17 interaction.	Heparitin Sulfate	76-78	family with sequence similarity 72 member B	Homo sapiens	150-153
23166320-8	2013	Competition experiments demonstrated that free heparin and heparan sulfate (HS), but not selectively 2-O-, 6-O-, and N-O desulfated heparins, prevent p17 binding to substrate-immobilized heparin, indicating that the sulfate groups of the glycosaminoglycan mediate p17 interaction.	Heparitin Sulfate	76-78	family with sequence similarity 72 member B	Homo sapiens	264-267
23166320-9	2013	Evaluation of the p17 antagonist activity of a panel of biotechnological heparins derived by chemical sulfation of the Escherichia coli K5 polysaccharide revealed that the highly N,O-sulfated derivative prevents the binding of p17 to both heparin and CXCR1, thus inhibiting p17-driven chemotactic migration of human monocytes with an efficiency that is higher than those of heparin and HS.	Heparitin Sulfate	386-388	family with sequence similarity 72 member B	Homo sapiens	18-21
23166320-9	2013	Evaluation of the p17 antagonist activity of a panel of biotechnological heparins derived by chemical sulfation of the Escherichia coli K5 polysaccharide revealed that the highly N,O-sulfated derivative prevents the binding of p17 to both heparin and CXCR1, thus inhibiting p17-driven chemotactic migration of human monocytes with an efficiency that is higher than those of heparin and HS.	Heparitin Sulfate	386-388	family with sequence similarity 72 member B	Homo sapiens	227-230
23166320-9	2013	Evaluation of the p17 antagonist activity of a panel of biotechnological heparins derived by chemical sulfation of the Escherichia coli K5 polysaccharide revealed that the highly N,O-sulfated derivative prevents the binding of p17 to both heparin and CXCR1, thus inhibiting p17-driven chemotactic migration of human monocytes with an efficiency that is higher than those of heparin and HS.	Heparitin Sulfate	386-388	family with sequence similarity 72 member B	Homo sapiens	227-230
23172228-0	2013	The C-terminal peptide of chondroadherin modulates cellular activity by selectively binding to heparan sulfate chains.	Heparitin Sulfate	95-110	chondroadherin	Homo sapiens	26-40
23161803-8	2013	We found that Equarin promoted lens cell adhesion through heparan sulfate proteoglycan.	Heparitin Sulfate	58-73	coiled-coil domain containing 80	Gallus gallus	14-21
23302472-3	2013	BoHV-4 Open Reading Frame 8 (ORF8) codifies for glycoprotein B (gB) that shows a heterodimeric structure, composed of two subunits and covalently linked by disulfide bonds and responsible for host cell adhesion through binding to heparan sulfates associated with cellular proteoglycans.	Heparitin Sulfate	230-246	glycoprotein B	Bovine gammaherpesvirus 4	48-62
23391418-3	2013	As the variant exon CD44v3 binds heparan sulphate and facilitates preservation of growth factors, we hypothesized that the variably spliced exon region of CD44, especially exon CD44v3, is involved in arteriogenesis.	Heparitin Sulfate	33-49	CD44 antigen	Mus musculus	20-24
23484086-3	2013	hRNase3 has multiple functions including ribonucleolytic, heparan sulfate (HS) binding, cellular binding, endocytic, lipid destabilization, cytotoxic, and antimicrobial activities.	Heparitin Sulfate	58-73	ribonuclease A family member 3	Homo sapiens	0-7
23484086-3	2013	hRNase3 has multiple functions including ribonucleolytic, heparan sulfate (HS) binding, cellular binding, endocytic, lipid destabilization, cytotoxic, and antimicrobial activities.	Heparitin Sulfate	75-77	ribonuclease A family member 3	Homo sapiens	0-7
22020734-1	2013	Heparanase is an endo-beta-D-glucuronidase enzyme which degrades heparan sulfate glycosaminoglycan side chains of proteoglycans in the extracellular matrix and in basement membranes.	Heparitin Sulfate	65-80	heparanase	Homo sapiens	0-10
24253340-5	2013	In addition, this intergenic SNP significantly predicts postmortem cerebellar gene expression of NDST3, which encodes an enzyme critical to heparan sulphate metabolism.	Heparitin Sulfate	140-156	N-deacetylase and N-sulfotransferase 3	Homo sapiens	97-102
23739639-2	2013	Here we demonstrate that a cell surface scavenger receptor, macrophage receptor with collagenous structure (MARCO), previously thought to enhance antiviral defense by enabling nucleic acid recognition, is usurped by herpes simplex virus type 1 and functions together with heparan sulphate proteoglycans to mediate adsorption to epithelial cells.	Heparitin Sulfate	272-288	macrophage receptor with collagenous structure	Homo sapiens	108-113
22020734-1	2013	Heparanase is an endo-beta-D-glucuronidase enzyme which degrades heparan sulfate glycosaminoglycan side chains of proteoglycans in the extracellular matrix and in basement membranes.	Heparitin Sulfate	65-80	glucuronidase beta	Homo sapiens	22-42
23358893-4	2013	The rare modification of 3-O-sulfation on HS chain is governed by enzymes known as 3-O-sulfotransferase (3-OST).	Heparitin Sulfate	42-44	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	83-103
23883774-2	2013	We previously reported the colocalization of non-enzymatic ArsA with heparan sulfate proteoglycan on cell surfaces in the mouse liver using tissues processed with phosphate-buffered saline containing Ca2+ and Mg2+.	Heparitin Sulfate	69-84	arylsulfatase A	Mus musculus	59-63
23358893-4	2013	The rare modification of 3-O-sulfation on HS chain is governed by enzymes known as 3-O-sulfotransferase (3-OST).	Heparitin Sulfate	42-44	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	105-110
23990784-2	2013	A27 protein binds to cell surface heparan sulfate, provides an anchor for A26 protein packaging into mature virions, and is essential for egress of mature virus (MV) from infected cells.	Heparitin Sulfate	34-49	immunoglobulin kappa variable 3-20	Homo sapiens	0-3
23555036-6	2013	TGF-beta was able to bind to the surface of lymphoma B cells through an interaction with heparan sulfate (HS) but not through the TGF-beta receptor.	Heparitin Sulfate	89-104	transforming growth factor beta 1	Homo sapiens	0-8
23555036-6	2013	TGF-beta was able to bind to the surface of lymphoma B cells through an interaction with heparan sulfate (HS) but not through the TGF-beta receptor.	Heparitin Sulfate	106-108	transforming growth factor beta 1	Homo sapiens	0-8
23437253-3	2013	Size-exclusion chromatography shows that full length SMOC-1 as well as its C-terminal EC domain alone bind heparin and heparan sulfate, but not the related chondroitin sulfate or dermatan sulfate glycosaminoglycans.	Heparitin Sulfate	119-134	SPARC related modular calcium binding 1	Homo sapiens	53-59
22672269-0	2012	Heparin affin regulatory peptide modulates the endogenous anticoagulant activity of heparin and heparan sulphate mimetics.	Heparitin Sulfate	96-112	pleiotrophin	Homo sapiens	0-32
23142801-5	2013	In this context, we investigate whether a device containing heparan sulfate (HS), which is a co-factor in growth factor-mediated cell proliferation and differentiation, could potentiate and prolong the delivery of fibroblast growth factor-2 (FGF-2) and thus improve in vitro NSC cultivation.	Heparitin Sulfate	60-75	fibroblast growth factor 2	Homo sapiens	214-240
23142801-5	2013	In this context, we investigate whether a device containing heparan sulfate (HS), which is a co-factor in growth factor-mediated cell proliferation and differentiation, could potentiate and prolong the delivery of fibroblast growth factor-2 (FGF-2) and thus improve in vitro NSC cultivation.	Heparitin Sulfate	60-75	fibroblast growth factor 2	Homo sapiens	242-247
23142801-5	2013	In this context, we investigate whether a device containing heparan sulfate (HS), which is a co-factor in growth factor-mediated cell proliferation and differentiation, could potentiate and prolong the delivery of fibroblast growth factor-2 (FGF-2) and thus improve in vitro NSC cultivation.	Heparitin Sulfate	77-79	fibroblast growth factor 2	Homo sapiens	214-240
23142801-5	2013	In this context, we investigate whether a device containing heparan sulfate (HS), which is a co-factor in growth factor-mediated cell proliferation and differentiation, could potentiate and prolong the delivery of fibroblast growth factor-2 (FGF-2) and thus improve in vitro NSC cultivation.	Heparitin Sulfate	77-79	fibroblast growth factor 2	Homo sapiens	242-247
23022219-1	2012	Mucopolysaccharidosis IIIA (MPS IIIA) is a lysosomal storage disorder caused by a deficiency in the activity of the lysosomal hydrolase, sulphamidase, an enzyme involved in the degradation of heparan sulphate.	Heparitin Sulfate	192-208	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	137-149
22899865-9	2012	The EXT2 protein, which when combined as heterodimers with EXT1 comprises the major polymerase in heparan sulfate synthesis, has been studied in depth.	Heparitin Sulfate	98-113	exostosin glycosyltransferase 2	Homo sapiens	4-8
23853587-8	2013	Like TSP-1, BAD-1 blocks activation of T cells in a manner requiring the heparan sulfate-modified surface molecule CD47, and impairs effector functions.	Heparitin Sulfate	73-88	thrombospondin 1	Homo sapiens	5-10
23853587-8	2013	Like TSP-1, BAD-1 blocks activation of T cells in a manner requiring the heparan sulfate-modified surface molecule CD47, and impairs effector functions.	Heparitin Sulfate	73-88	CD47 molecule	Homo sapiens	115-119
23118222-0	2012	An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions.	Heparitin Sulfate	62-77	sonic hedgehog	Mus musculus	20-34
23074159-0	2012	Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.	Heparitin Sulfate	68-83	sulfatase 1	Homo sapiens	32-37
23074159-0	2012	Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.	Heparitin Sulfate	68-83	heparan sulfate 6-O-sulfotransferase 1	Homo sapiens	42-48
22672269-2	2012	In this work, HARP was tested for its capacity to modulate the anticoagulant activity of heparin and heparan sulphate mimetics (OTR4120).	Heparitin Sulfate	101-117	pleiotrophin	Homo sapiens	14-18
22672269-4	2012	HARP was found to be differently effective for neutralization of the anticoagulant activity of the mimetic heparan sulphate (OTR4120) and heparin in purified system and human plasma.	Heparitin Sulfate	107-123	pleiotrophin	Homo sapiens	0-4
23093424-7	2012	Mutations in these glypican genes and in heparan sulfate biosynthetic genes result in disruption of JAK/STAT signaling, loss or abnormal formation of the stalk and significant reduction in the accumulation of extracellular Upd.	Heparitin Sulfate	41-56	hopscotch	Drosophila melanogaster	100-103
22922164-3	2012	We provide evidence that two parts of C. elegans glypican LON-2 can independently inhibit BMP signaling in vivo: the N-terminal furin protease product and the C-terminal region containing heparan sulfate attachment sequences.	Heparitin Sulfate	188-203	LONg	Caenorhabditis elegans	58-63
23093424-7	2012	Mutations in these glypican genes and in heparan sulfate biosynthetic genes result in disruption of JAK/STAT signaling, loss or abnormal formation of the stalk and significant reduction in the accumulation of extracellular Upd.	Heparitin Sulfate	41-56	Signal-transducer and activator of transcription protein at 92E	Drosophila melanogaster	104-108
23093424-7	2012	Mutations in these glypican genes and in heparan sulfate biosynthetic genes result in disruption of JAK/STAT signaling, loss or abnormal formation of the stalk and significant reduction in the accumulation of extracellular Upd.	Heparitin Sulfate	41-56	unpaired 1	Drosophila melanogaster	223-226
22801553-0	2012	Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage.	Heparitin Sulfate	97-112	glypican 1	Homo sapiens	43-53
22801553-5	2012	However, Gpc-1 contains two more, non-conserved cysteines in the C-terminal stalk, located near the HS attachment sites.	Heparitin Sulfate	100-102	glypican 1	Homo sapiens	9-14
22985516-0	2012	Fractone-heparan sulfates mediate BMP-7 inhibition of cell proliferation in the adult subventricular zone.	Heparitin Sulfate	9-25	bone morphogenetic protein 7	Mus musculus	34-39
22936797-2	2012	Islet amyloid also contains heparan sulfate proteoglycans (HSPGs) that may contribute to amyloid formation by binding IAPP via their heparan sulfate (HS) chains.	Heparitin Sulfate	28-43	islet amyloid polypeptide	Mus musculus	118-122
22936797-2	2012	Islet amyloid also contains heparan sulfate proteoglycans (HSPGs) that may contribute to amyloid formation by binding IAPP via their heparan sulfate (HS) chains.	Heparitin Sulfate	59-61	islet amyloid polypeptide	Mus musculus	118-122
22936797-3	2012	We hypothesized that beta-cells produce HS that bind IAPP via regions of highly sulfated disaccharides.	Heparitin Sulfate	40-42	islet amyloid polypeptide	Mus musculus	53-57
22936797-7	2012	In contrast, IAPP-bound HS from NMuMG cells contained frequent highly sulfated regions, whereas the non-bound material demonstrated fewer sulfated regions.	Heparitin Sulfate	24-26	islet amyloid polypeptide	Mus musculus	13-17
22936797-9	2012	Desulfation of HS decreased the ability of both beta-TC3 and NMuMG HS to stimulate IAPP maximal fibril formation, but desulfated HS from both cell types still accelerated fibril formation relative to IAPP alone.	Heparitin Sulfate	15-17	islet amyloid polypeptide	Mus musculus	83-87
22936797-9	2012	Desulfation of HS decreased the ability of both beta-TC3 and NMuMG HS to stimulate IAPP maximal fibril formation, but desulfated HS from both cell types still accelerated fibril formation relative to IAPP alone.	Heparitin Sulfate	67-69	islet amyloid polypeptide	Mus musculus	83-87
22936797-9	2012	Desulfation of HS decreased the ability of both beta-TC3 and NMuMG HS to stimulate IAPP maximal fibril formation, but desulfated HS from both cell types still accelerated fibril formation relative to IAPP alone.	Heparitin Sulfate	67-69	islet amyloid polypeptide	Mus musculus	83-87
22985516-7	2012	BMP-7 binding was seen as puncta in the SVZ at the location of fractones, the particulate specialized extracellular matrix of the SVZ, which have been identified primarily by N-sulfated heparan sulfate immunoreactivity (NS-HS+).	Heparitin Sulfate	186-201	bone morphogenetic protein 7	Mus musculus	0-5
22985516-10	2012	These results indicate that BMP-7 requires heparan sulfates to bind and inhibit cell proliferation in the SVZ neurogenic niche.	Heparitin Sulfate	43-59	bone morphogenetic protein 7	Mus musculus	28-33
22927437-2	2012	The activity of these growth factors is regulated by heparan sulfate (HS), which is essential for the formation of FGF2/FGF receptor (FGFR) and VEGF(165)/VEGF receptor signaling complexes.	Heparitin Sulfate	70-72	vascular endothelial growth factor A	Homo sapiens	154-158
23095131-3	2012	Heparanase-1, an endoglycosidase that cleaves heparan sulfate, is implicated in the pathogenesis of diabetic nephropathy and is necessary to FGF-2 for the induction of tubular cells transition.	Heparitin Sulfate	46-61	heparanase	Homo sapiens	0-12
23095131-3	2012	Heparanase-1, an endoglycosidase that cleaves heparan sulfate, is implicated in the pathogenesis of diabetic nephropathy and is necessary to FGF-2 for the induction of tubular cells transition.	Heparitin Sulfate	46-61	fibroblast growth factor 2	Homo sapiens	141-146
22927437-2	2012	The activity of these growth factors is regulated by heparan sulfate (HS), which is essential for the formation of FGF2/FGF receptor (FGFR) and VEGF(165)/VEGF receptor signaling complexes.	Heparitin Sulfate	53-68	fibroblast growth factor 2	Homo sapiens	115-119
22927437-2	2012	The activity of these growth factors is regulated by heparan sulfate (HS), which is essential for the formation of FGF2/FGF receptor (FGFR) and VEGF(165)/VEGF receptor signaling complexes.	Heparitin Sulfate	53-68	vascular endothelial growth factor A	Homo sapiens	144-148
22927437-5	2012	Reduced HS 6-O-sulfotransferase 1 (HS6ST-1) or 6-O-sulfotransferase 2 (HS6ST-2) expression in endothelial cells impacts upon the prevalence of HS 6-O-sulfate moieties in HS sequences, which consist of repeating short, highly sulfated S domains interspersed by transitional N-acetylated/N-sulfated domains.	Heparitin Sulfate	8-10	heparan sulfate 6-O-sulfotransferase 1	Homo sapiens	35-42
22927437-2	2012	The activity of these growth factors is regulated by heparan sulfate (HS), which is essential for the formation of FGF2/FGF receptor (FGFR) and VEGF(165)/VEGF receptor signaling complexes.	Heparitin Sulfate	53-68	vascular endothelial growth factor A	Homo sapiens	154-158
22927437-2	2012	The activity of these growth factors is regulated by heparan sulfate (HS), which is essential for the formation of FGF2/FGF receptor (FGFR) and VEGF(165)/VEGF receptor signaling complexes.	Heparitin Sulfate	70-72	fibroblast growth factor 2	Homo sapiens	115-119
22915586-8	2012	Because NE is known to bind to heparan sulfate- and chondroitin sulfate-containing proteoglycans, we treated cells with glycanases to remove these confounding factors, which did not significantly diminish cell surface binding or endosomal entry.	Heparitin Sulfate	31-46	elastase, neutrophil expressed	Homo sapiens	8-10
22927437-2	2012	The activity of these growth factors is regulated by heparan sulfate (HS), which is essential for the formation of FGF2/FGF receptor (FGFR) and VEGF(165)/VEGF receptor signaling complexes.	Heparitin Sulfate	70-72	vascular endothelial growth factor A	Homo sapiens	144-148
22760779-0	2012	Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation.	Heparitin Sulfate	0-15	toll like receptor 4	Homo sapiens	31-35
23035208-3	2012	METHODS AND RESULTS: We engineered a mouse carrying a Cxcl12 gene (Cxcl12(Gagtm)) mutation that precludes interactions with heparan sulfate structures while not affecting CXCR4-dependent cell signaling of CXCL12 isoforms (alpha, beta, gamma).	Heparitin Sulfate	124-139	chemokine (C-X-C motif) ligand 12	Mus musculus	54-60
23035208-3	2012	METHODS AND RESULTS: We engineered a mouse carrying a Cxcl12 gene (Cxcl12(Gagtm)) mutation that precludes interactions with heparan sulfate structures while not affecting CXCR4-dependent cell signaling of CXCL12 isoforms (alpha, beta, gamma).	Heparitin Sulfate	124-139	chemokine (C-X-C motif) ligand 12	Mus musculus	67-73
23035208-6	2012	Importantly, exogenous administration of CXCL12gamma, which binds heparan sulfate with the highest affinity ever reported for a cytokine, fully restores vascular growth, whereas heparan sulfate-binding CXCL12gamma mutants failed to promote revascularization in Cxcl12(Gagtm/Gagtm) animals.	Heparitin Sulfate	66-81	chemokine (C-X-C motif) ligand 12	Mus musculus	41-47
23035208-7	2012	CONCLUSION: These findings prove the role played by heparan sulfate interactions in the functions of CXCL12 in both homeostasis and physiopathological settings and document for the first time the paradigm of chemokine immobilization in vivo.	Heparitin Sulfate	52-67	chemokine (C-X-C motif) ligand 12	Mus musculus	101-107
23043026-1	2012	In this issue of Blood, Brennan et al report that a noninfectious damage-associated molecular pattern (DAMP), heparan sulfate (HS),(1) aggravates graft-versus-host disease (GVHD) and that this enhanced severity can be dampened by administration of serine protease inhibitor alpha-1 antitrysin (AAT).	Heparitin Sulfate	110-125	adrenoceptor alpha 1D	Homo sapiens	274-281
22760779-3	2012	In this study, we showed that heparan sulfate (HS), an extracellular matrix component, can activate Toll-like receptor 4 on dendritic cells in vitro, leading to the enhancement of dendritic cell maturation and alloreactive T-cell responses.	Heparitin Sulfate	30-45	toll like receptor 4	Homo sapiens	100-120
23043026-1	2012	In this issue of Blood, Brennan et al report that a noninfectious damage-associated molecular pattern (DAMP), heparan sulfate (HS),(1) aggravates graft-versus-host disease (GVHD) and that this enhanced severity can be dampened by administration of serine protease inhibitor alpha-1 antitrysin (AAT).	Heparitin Sulfate	127-129	adrenoceptor alpha 1D	Homo sapiens	274-281
22760779-3	2012	In this study, we showed that heparan sulfate (HS), an extracellular matrix component, can activate Toll-like receptor 4 on dendritic cells in vitro, leading to the enhancement of dendritic cell maturation and alloreactive T-cell responses.	Heparitin Sulfate	47-49	toll like receptor 4	Homo sapiens	100-120
22869369-7	2012	Thus, the balance of the Extl3 and Csgalnact1/Csgalnact2 proteins influences the HS/CS ratio.	Heparitin Sulfate	81-83	exostosin-like glycosyltransferase 3	Danio rerio	25-30
22961711-0	2012	Chemical synthesis of a heparan sulfate glycopeptide: syndecan-1.	Heparitin Sulfate	24-39	syndecan 1	Homo sapiens	54-64
22692572-4	2012	To study the role of heparan sulfate proteoglycans in neuroinflammation, we employed a transgenic mouse overexpressing heparanase, an endoglucuronidase that specifically degrades heparan sulfate side chains.	Heparitin Sulfate	179-194	heparanase	Mus musculus	119-129
22692572-10	2012	Our data indicate that intact heparan sulfate chains are required at multiple sites to mediate neuroinflammatory responses, and further point to heparanase as a modulator of this process, with potential implications for Alzheimer"s disease.	Heparitin Sulfate	30-45	heparanase	Mus musculus	145-155
22841476-2	2012	The heparan sulphate chains substituted on to the syndecan ectodomains are capable of engaging ligands over great distance, while the protein core spans the plasma membrane and initiates cytoplasmic signals through a short cytoplasmic tail.	Heparitin Sulfate	4-20	syndecan 1	Homo sapiens	50-58
22692045-0	2012	Substrate specificity of 6-O-endosulfatase (Sulf-2) and its implications in synthesizing anticoagulant heparan sulfate.	Heparitin Sulfate	103-118	sulfatase 2	Homo sapiens	44-50
22869369-2	2012	uxs1 and b3gat3 mutants, predicted to have impaired biosynthesis of both HS and CS because of defective formation of the common proteoglycan linkage tetrasaccharide were analyzed along with ext2 and extl3 mutants, predicted to have defective HS polymerization.	Heparitin Sulfate	73-75	UDP-glucuronate decarboxylase 1	Danio rerio	0-4
22869369-5	2012	extl3 and ext2 mutants on the other hand were shown to synthesize reduced amounts of hypersulfated HS.	Heparitin Sulfate	99-101	exostosin-like glycosyltransferase 3	Danio rerio	0-5
22869369-7	2012	Thus, the balance of the Extl3 and Csgalnact1/Csgalnact2 proteins influences the HS/CS ratio.	Heparitin Sulfate	81-83	chondroitin sulfate N-acetylgalactosaminyltransferase 1a	Danio rerio	35-45
22869369-5	2012	extl3 and ext2 mutants on the other hand were shown to synthesize reduced amounts of hypersulfated HS.	Heparitin Sulfate	99-101	exostosin glycosyltransferase 2	Danio rerio	10-14
22869369-7	2012	Thus, the balance of the Extl3 and Csgalnact1/Csgalnact2 proteins influences the HS/CS ratio.	Heparitin Sulfate	81-83	chondroitin sulfate N-acetylgalactosaminyltransferase 2	Danio rerio	46-56
22331282-1	2012	Heparanase is the sole mammalian endoglycosidase that cleaves heparan sulfate, the key polysaccharide of the extracellular matrix and basement membranes.	Heparitin Sulfate	62-77	heparanase	Homo sapiens	0-10
22865881-3	2012	We previously showed that the heparan sulfate (HS) 6-O-endosulfatases (Sulf1 and -2) repress FGF signaling to induce SC differentiation during muscle regeneration.	Heparitin Sulfate	30-45	sulfatase 1	Mus musculus	71-83
22573479-2	2012	In breast cancer, overexpression of the transmembrane heparan sulfate proteoglycan syndecan-1, a predicted target of the oncomiR miR-10b, correlates with poor clinical outcome.	Heparitin Sulfate	54-69	syndecan 1	Homo sapiens	83-93
22573479-2	2012	In breast cancer, overexpression of the transmembrane heparan sulfate proteoglycan syndecan-1, a predicted target of the oncomiR miR-10b, correlates with poor clinical outcome.	Heparitin Sulfate	54-69	microRNA 10b	Homo sapiens	129-136
22759380-7	2012	These observations indicate that heparin binds endogenous GDF9 and disrupts interaction with heparan sulphate proteoglycan coreceptor(s), important for GDF9 signaling.	Heparitin Sulfate	93-109	growth differentiation factor 9	Homo sapiens	152-156
22761365-2	2012	At the outset of infection, the interaction of HPV type 16 (HPV16) (pseudo)virions with heparan sulfate proteoglycans triggers a conformational change in L2 that is facilitated by the host cell chaperone cyclophilin B (CyPB).	Heparitin Sulfate	88-103	peptidylprolyl isomerase B	Homo sapiens	219-223
22815489-0	2012	Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.	Heparitin Sulfate	80-95	complement factor H	Homo sapiens	0-8
22879413-8	2012	SPR data demonstrated the ability of FIB to bind noncovalently to corneal stroma molecules, Coll-I, decorin, dermatan sulfate, and corneal basement membrane molecules, laminin and heparan sulfate--only in the presence of Zn(2+).	Heparitin Sulfate	180-195	fibrinogen beta chain	Homo sapiens	37-40
22867887-1	2012	Mucopolysaccharidosis type IIIB (MPS IIIB) is a neuropathic lysosomal storage disorder (LSD) resulting from an inherited deficiency of N-acetyl-alpha-D-glucosaminidase (Naglu) activity, an enzyme required to degrade the glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	238-253	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	135-167
22867887-1	2012	Mucopolysaccharidosis type IIIB (MPS IIIB) is a neuropathic lysosomal storage disorder (LSD) resulting from an inherited deficiency of N-acetyl-alpha-D-glucosaminidase (Naglu) activity, an enzyme required to degrade the glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	238-253	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	169-174
22867887-1	2012	Mucopolysaccharidosis type IIIB (MPS IIIB) is a neuropathic lysosomal storage disorder (LSD) resulting from an inherited deficiency of N-acetyl-alpha-D-glucosaminidase (Naglu) activity, an enzyme required to degrade the glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	255-257	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	135-167
22867887-1	2012	Mucopolysaccharidosis type IIIB (MPS IIIB) is a neuropathic lysosomal storage disorder (LSD) resulting from an inherited deficiency of N-acetyl-alpha-D-glucosaminidase (Naglu) activity, an enzyme required to degrade the glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	255-257	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	169-174
22791291-2	2012	We showed previously that heparan sulfate, a type of sulfated glycosaminoglycan, facilitates neutrophil recruitment based on the reduction of neutrophil infiltration in mice in which the overall sulfation of the chains was reduced by selective inactivation of N-acetylglucosamine N-deacetylase-N-sulfotransferase (Ndst1) in endothelial cells.	Heparitin Sulfate	26-41	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	314-319
24843591-10	2012	CONCLUSIONS:   Our data suggest that the 3-O-sulfate group of HS that is modified by Hs3st1 plays a significant role(s) in the insulin secretory pathway, selectively through an interaction with factor(s) upstream of membrane depolarization in beta-cells.	Heparitin Sulfate	62-64	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	Mus musculus	85-91
22805760-1	2012	D-glucuronyl C5-epimerase (GLCE) is a potential tumor-suppressor gene involved in heparan sulfate biosynthesis.	Heparitin Sulfate	82-97	glucuronic acid epimerase	Homo sapiens	0-25
22805760-1	2012	D-glucuronyl C5-epimerase (GLCE) is a potential tumor-suppressor gene involved in heparan sulfate biosynthesis.	Heparitin Sulfate	82-97	glucuronic acid epimerase	Homo sapiens	27-31
22547151-1	2012	Mucopolysaccharidosis IIIA (MPS IIIA or Sanfilippo disease) is a neurodegenerative disorder caused by a deficiency in the lysosomal enzyme sulfamidase (SGSH), catabolizing heparan sulfate (HS).	Heparitin Sulfate	172-187	N-sulfoglucosamine sulfohydrolase	Homo sapiens	152-156
21811836-4	2012	In a series of studies performed since the cloning of the human heparanase gene, we and others have demonstrated that heparanase, the sole heparan sulfate degrading endoglycosidase, is causally involved in cancer progression, inflammation and diabetic nephropathy and hence is a valid target for drug development.	Heparitin Sulfate	139-154	heparanase	Homo sapiens	118-128
21811836-7	2012	Heparanase also plays a decisive role in the pathogenesis of diabetic nephropathy, degrading heparan sulfate in the glomerular basement membrane and ultimately leading to proteinuria and kidney dysfunction.	Heparitin Sulfate	93-108	heparanase	Homo sapiens	0-10
22547151-1	2012	Mucopolysaccharidosis IIIA (MPS IIIA or Sanfilippo disease) is a neurodegenerative disorder caused by a deficiency in the lysosomal enzyme sulfamidase (SGSH), catabolizing heparan sulfate (HS).	Heparitin Sulfate	189-191	N-sulfoglucosamine sulfohydrolase	Homo sapiens	152-156
22579681-2	2012	ECP has a high binding affinity for heterosaccharides, such as bacterial lipopolysaccharides and heparan sulfate found in the glycocalix of eukaryotic cells.	Heparitin Sulfate	97-112	ribonuclease A family member 3	Homo sapiens	0-3
22654109-0	2012	Heparan sulfate dissociates serum amyloid A (SAA) from acute-phase high-density lipoprotein, promoting SAA aggregation.	Heparitin Sulfate	0-15	serum amyloid A cluster	Mus musculus	28-43
22654109-0	2012	Heparan sulfate dissociates serum amyloid A (SAA) from acute-phase high-density lipoprotein, promoting SAA aggregation.	Heparitin Sulfate	0-15	serum amyloid A cluster	Mus musculus	45-48
22654109-0	2012	Heparan sulfate dissociates serum amyloid A (SAA) from acute-phase high-density lipoprotein, promoting SAA aggregation.	Heparitin Sulfate	0-15	serum amyloid A cluster	Mus musculus	103-106
22467855-1	2012	Glypican-3 (GPC3) is a heparan sulfate (HS) proteoglycan that is bound to the cell membrane through a glycosylphosphatidylinositol link.	Heparitin Sulfate	23-38	glypican 3	Homo sapiens	0-10
22467855-1	2012	Glypican-3 (GPC3) is a heparan sulfate (HS) proteoglycan that is bound to the cell membrane through a glycosylphosphatidylinositol link.	Heparitin Sulfate	23-38	glypican 3	Homo sapiens	12-16
22467855-1	2012	Glypican-3 (GPC3) is a heparan sulfate (HS) proteoglycan that is bound to the cell membrane through a glycosylphosphatidylinositol link.	Heparitin Sulfate	40-42	glypican 3	Homo sapiens	0-10
22467855-1	2012	Glypican-3 (GPC3) is a heparan sulfate (HS) proteoglycan that is bound to the cell membrane through a glycosylphosphatidylinositol link.	Heparitin Sulfate	40-42	glypican 3	Homo sapiens	12-16
22615183-0	2012	Synthesis of a heparan sulfate mimetic library targeting FGF and VEGF via click chemistry on a monosaccharide template.	Heparitin Sulfate	15-30	vascular endothelial growth factor A	Homo sapiens	65-69
22532692-0	2012	Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfate.	Heparitin Sulfate	82-97	apolipoprotein E	Homo sapiens	41-57
22066689-2	2012	Here we show that supplementation with an embryonic form of heparan sulfate (HS-2) can both increase the initial recovery of hMSCs from bone marrow aspirates and increase their ex vivo expansion by up to 13-fold.	Heparitin Sulfate	60-75	spectrin beta, erythrocytic	Homo sapiens	77-81
22815649-14	2012	We propose that this spatial organisation, coupled to the relative selectivity and the availability of HS-binding sites, determines the transport of FGF2 in matrices.	Heparitin Sulfate	103-105	fibroblast growth factor 2	Homo sapiens	149-153
21739484-6	2012	This study reveals a novel layer of regulation of heparan-binding growth factor signaling via modulation of heparan sulfate by HSulf-2 in ccRCC.	Heparitin Sulfate	108-123	sulfatase 2	Homo sapiens	127-134
22532692-11	2012	Collectively, these findings demonstrate that apoE mediates HCV attachment through specific interactions with cell surface heparan sulfate.	Heparitin Sulfate	123-138	apolipoprotein E	Homo sapiens	46-50
22815649-0	2012	Transport of fibroblast growth factor 2 in the pericellular matrix is controlled by the spatial distribution of its binding sites in heparan sulfate.	Heparitin Sulfate	133-148	fibroblast growth factor 2	Homo sapiens	13-39
22577146-5	2012	We also demonstrated that heparan sulfate was required for thrombin-mediated activation of pro-MMP-2 by binding to thrombin, presumably through conformational changes at the active site of the enzyme.	Heparitin Sulfate	26-41	coagulation factor II, thrombin	Homo sapiens	59-67
26105221-6	2012	Plasma levels of endogenous TLR4 ligands-heparan sulfate, hyaluronan, fibronectin, fibrinogen and High mobility group box-1(HMGB1)-were measured by ELISA.	Heparitin Sulfate	41-56	toll like receptor 4	Homo sapiens	28-32
22423048-6	2012	We determined that PSG22, like human PSG1 and murine PSG17 and PSG23, binds to the heparan sulfate chains in syndecans.	Heparitin Sulfate	83-98	pregnancy-specific glycoprotein 22	Mus musculus	19-24
22423048-6	2012	We determined that PSG22, like human PSG1 and murine PSG17 and PSG23, binds to the heparan sulfate chains in syndecans.	Heparitin Sulfate	83-98	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	37-41
22423048-6	2012	We determined that PSG22, like human PSG1 and murine PSG17 and PSG23, binds to the heparan sulfate chains in syndecans.	Heparitin Sulfate	83-98	pregnancy specific glycoprotein 17	Mus musculus	53-58
22423048-6	2012	We determined that PSG22, like human PSG1 and murine PSG17 and PSG23, binds to the heparan sulfate chains in syndecans.	Heparitin Sulfate	83-98	pregnancy-specific glycoprotein 23	Mus musculus	63-68
22577146-5	2012	We also demonstrated that heparan sulfate was required for thrombin-mediated activation of pro-MMP-2 by binding to thrombin, presumably through conformational changes at the active site of the enzyme.	Heparitin Sulfate	26-41	matrix metallopeptidase 2	Homo sapiens	95-100
22577146-5	2012	We also demonstrated that heparan sulfate was required for thrombin-mediated activation of pro-MMP-2 by binding to thrombin, presumably through conformational changes at the active site of the enzyme.	Heparitin Sulfate	26-41	coagulation factor II, thrombin	Homo sapiens	115-123
22471560-0	2012	Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin.	Heparitin Sulfate	60-75	complement factor H	Homo sapiens	37-56
22689975-3	2012	Here we show that the lysosomal arylsulfatase G (ARSG) is the long-sought glucosamine-3-O-sulfatase required to complete the degradation of heparan sulfate.	Heparitin Sulfate	140-155	arylsulfatase G	Mus musculus	32-47
22689975-3	2012	Here we show that the lysosomal arylsulfatase G (ARSG) is the long-sought glucosamine-3-O-sulfatase required to complete the degradation of heparan sulfate.	Heparitin Sulfate	140-155	arylsulfatase G	Mus musculus	49-53
22689975-4	2012	Arsg-deficient mice accumulate heparan sulfate in visceral organs and the central nervous system and develop neuronal cell death and behavioral deficits.	Heparitin Sulfate	31-46	arylsulfatase G	Mus musculus	0-4
22689975-7	2012	Our results demonstrate the key role of ARSG in heparan sulfate degradation and strongly suggest that ARSG deficiency represents a unique, as yet unknown form of MPS, which we term MPS IIIE.	Heparitin Sulfate	48-63	arylsulfatase G	Mus musculus	40-44
22471560-9	2012	This bivalent and co-operative model of FH binding to heparan sulfate provides novel insights on the immune function of FH at host cell surfaces.	Heparitin Sulfate	54-69	complement factor H	Homo sapiens	40-42
22471560-9	2012	This bivalent and co-operative model of FH binding to heparan sulfate provides novel insights on the immune function of FH at host cell surfaces.	Heparitin Sulfate	54-69	complement factor H	Homo sapiens	120-122
22492674-8	2012	Conditioned medium from heparan sulfate-activated macrophages, which contained MCP3, induced the migration of CAC (one-fold increase, P= 0.01).	Heparitin Sulfate	24-39	chemokine (C-C motif) ligand 7	Mus musculus	79-83
22660413-4	2012	Syntenin exosomes depend on the availability of heparan sulphate, syndecans, ALIX and ESCRTs, and impact on the trafficking and confinement of FGF signals.	Heparitin Sulfate	48-64	syndecan binding protein	Homo sapiens	0-8
22555965-2	2012	Smooth muscle specific deletion of one heparan sulfate biosynthetic enzyme, N-deacetylase-N-sulfotransferase1 leads to decreased vascular smooth muscle cell proliferation, and vascular wall thickness.	Heparitin Sulfate	39-54	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	76-109
22434139-4	2012	Because fibronectin contains heparin-binding domain, the interactions of fibronectin with heparan sulfate (HS) on cells might be inhibitory to FV transduction.	Heparitin Sulfate	90-105	fibronectin 1	Homo sapiens	8-19
22493510-7	2012	Furthermore, the colonization of the lungs by LLC cells was effectively inhibited by the blocking of CS or HS chains at the tumor cell surface with an anti-RAGE antibody through intravenous injections in a dose-dependent manner.	Heparitin Sulfate	107-109	advanced glycosylation end product-specific receptor	Mus musculus	156-160
22493510-8	2012	These results provide the clear evidence that RAGE is at least one of the critical receptors for CS and HS chains expressed at the tumor cell surface and involved in experimental lung metastasis and that CS/HS and RAGE are potential molecular targets in the treatment of pulmonary metastasis.	Heparitin Sulfate	104-106	advanced glycosylation end product-specific receptor	Mus musculus	46-50
22493510-8	2012	These results provide the clear evidence that RAGE is at least one of the critical receptors for CS and HS chains expressed at the tumor cell surface and involved in experimental lung metastasis and that CS/HS and RAGE are potential molecular targets in the treatment of pulmonary metastasis.	Heparitin Sulfate	207-209	advanced glycosylation end product-specific receptor	Mus musculus	46-50
22434139-4	2012	Because fibronectin contains heparin-binding domain, the interactions of fibronectin with heparan sulfate (HS) on cells might be inhibitory to FV transduction.	Heparitin Sulfate	90-105	fibronectin 1	Homo sapiens	73-84
22434139-4	2012	Because fibronectin contains heparin-binding domain, the interactions of fibronectin with heparan sulfate (HS) on cells might be inhibitory to FV transduction.	Heparitin Sulfate	107-109	fibronectin 1	Homo sapiens	8-19
22434139-4	2012	Because fibronectin contains heparin-binding domain, the interactions of fibronectin with heparan sulfate (HS) on cells might be inhibitory to FV transduction.	Heparitin Sulfate	107-109	fibronectin 1	Homo sapiens	73-84
22429964-11	2012	The RB4CD12 epitope in amyloid plaques was substantially degraded ex vivo by Sulf-1 and Sulf-2, extracellular HS endosulfatases.	Heparitin Sulfate	110-112	sulfatase 2	Homo sapiens	88-94
22484966-6	2012	Thus heparan sulfate-derived oligosaccharide storage is associated with abnormal lipid accumulation in both lysosomal (BMP) and non-lysosomal (GM3 and GM2) compartments.	Heparitin Sulfate	5-20	granulocyte macrophage antigen 3	Mus musculus	143-146
22484966-6	2012	Thus heparan sulfate-derived oligosaccharide storage is associated with abnormal lipid accumulation in both lysosomal (BMP) and non-lysosomal (GM3 and GM2) compartments.	Heparitin Sulfate	5-20	cytochrome b5 domain containing 2	Mus musculus	151-154
22285741-2	2012	In this paper, we exploit syndecan-4, a heparan sulfate proteoglycan obtained from cell cultures, in lipid Langmuir monolayers at the air-water interface.	Heparitin Sulfate	40-55	syndecan 4	Homo sapiens	26-36
22513363-1	2012	Heparanase is the only mammalian endoglycosidase which has been widely implicated in cancer because of its capability to degrade heparan sulfate chains of heparan sulfate proteoglycans (HSPG).	Heparitin Sulfate	129-144	heparanase	Homo sapiens	0-10
22583667-11	2012	DcR3s protein binding partners are minimally expressed or negative, however, all cells expressed the DcR3 binding Heparan Sulfate Proteoglycans (HSPGs) Syndecans-2, and CD44v3.	Heparitin Sulfate	114-129	TNF receptor superfamily member 6b	Homo sapiens	101-105
22643827-4	2012	Recent work from our group described a mechanism by which GBM regulates PDGFR-alpha signaling via enzymatic alteration of heparan sulfate proteoglycans (HSPGs) in the extracellular microenvironment.	Heparitin Sulfate	122-137	platelet derived growth factor receptor alpha	Homo sapiens	72-83
22223757-1	2012	Hepatoma-derived growth factor (HDGF) recognizes cell surface heparan sulfate to promote its internalization though binding to its N-terminal HATH (homologous to amino terminus of HDGF) domain.	Heparitin Sulfate	62-77	heparin binding growth factor	Homo sapiens	0-30
22223757-1	2012	Hepatoma-derived growth factor (HDGF) recognizes cell surface heparan sulfate to promote its internalization though binding to its N-terminal HATH (homologous to amino terminus of HDGF) domain.	Heparitin Sulfate	62-77	heparin binding growth factor	Homo sapiens	32-36
22223757-1	2012	Hepatoma-derived growth factor (HDGF) recognizes cell surface heparan sulfate to promote its internalization though binding to its N-terminal HATH (homologous to amino terminus of HDGF) domain.	Heparitin Sulfate	62-77	heparin binding growth factor	Homo sapiens	180-184
22447354-8	2012	We propose that TG2 amino acid sequences 202-215 and 261-274 could be involved in binding of TG2 to cell surface heparan sulfates.	Heparitin Sulfate	113-129	transglutaminase 2	Homo sapiens	16-19
22447354-8	2012	We propose that TG2 amino acid sequences 202-215 and 261-274 could be involved in binding of TG2 to cell surface heparan sulfates.	Heparitin Sulfate	113-129	transglutaminase 2	Homo sapiens	93-96
22351752-9	2012	In addition, we found that although syndecan-1 interacts exclusively through its glycosaminoglycan chains, syndecan-4 binding relies on both its core protein and its heparan sulfate chains.	Heparitin Sulfate	166-181	syndecan 4	Homo sapiens	107-117
22516446-4	2012	Heparanase is the major enzyme that degrades heparan sulfate in mammalian cells.	Heparitin Sulfate	45-60	heparanase	Homo sapiens	0-10
22520214-1	2012	BACKGROUND: Mucopolysaccharidosis type I (MPSI) is caused by a deficiency in alpha-L iduronidase (IDUA), which leads to lysosomal accumulation of the glycosaminoglycans (GAGs) dermatan and heparan sulfate.	Heparitin Sulfate	189-204	iduronidase, alpha-L	Mus musculus	98-102
22371501-5	2012	Moreover, GSPP competitively inhibited bFGF binding to heparin/heparan sulfate via direct binding to bFGF.	Heparitin Sulfate	63-78	fibroblast growth factor 2	Mus musculus	39-43
22371501-5	2012	Moreover, GSPP competitively inhibited bFGF binding to heparin/heparan sulfate via direct binding to bFGF.	Heparitin Sulfate	63-78	fibroblast growth factor 2	Mus musculus	101-105
22268118-2	2012	The functions of the mast cell chemoattractant CXCL10, and other chemokines, are regulated by binding to heparan sulphates such as syndecan-4.	Heparitin Sulfate	105-122	C-X-C motif chemokine ligand 10	Homo sapiens	47-53
22268118-2	2012	The functions of the mast cell chemoattractant CXCL10, and other chemokines, are regulated by binding to heparan sulphates such as syndecan-4.	Heparitin Sulfate	105-122	syndecan 4	Homo sapiens	131-141
22305926-1	2012	BACKGROUND AND AIMS: Heparanase (HPSE) is an endo-beta-D-glucuronidase, which cleaves heparan sulfate in the extracellular matrix (ECM) and has pro-angiogenic and pro-proliferative properties.	Heparitin Sulfate	86-101	heparanase	Rattus norvegicus	21-31
22227436-0	2012	Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2).	Heparitin Sulfate	20-35	bone morphogenetic protein 2	Bos taurus	75-103
22227436-0	2012	Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2).	Heparitin Sulfate	20-35	bone morphogenetic protein 2	Bos taurus	105-110
22227436-2	2012	To address this need, we explored the use of heparan sulfate (HS), a structural analog of heparin, to enhance BMP-2 activity.	Heparitin Sulfate	45-60	bone morphogenetic protein 2	Bos taurus	110-115
22227436-2	2012	To address this need, we explored the use of heparan sulfate (HS), a structural analog of heparin, to enhance BMP-2 activity.	Heparitin Sulfate	62-64	bone morphogenetic protein 2	Bos taurus	110-115
22305926-1	2012	BACKGROUND AND AIMS: Heparanase (HPSE) is an endo-beta-D-glucuronidase, which cleaves heparan sulfate in the extracellular matrix (ECM) and has pro-angiogenic and pro-proliferative properties.	Heparitin Sulfate	86-101	heparanase	Rattus norvegicus	33-37
22156940-2	2012	Our previous studies in mucopolysaccharidosis type IIIB (MPSIIIB), a disease in which a genetic defect induces the accumulation of undigested heparan sulfate (HS) fragments, led to the hypothesis that abnormal lysosome formation was related to events occurring at the Golgi level.	Heparitin Sulfate	142-157	N-acetyl-alpha-glucosaminidase	Homo sapiens	57-64
22156940-2	2012	Our previous studies in mucopolysaccharidosis type IIIB (MPSIIIB), a disease in which a genetic defect induces the accumulation of undigested heparan sulfate (HS) fragments, led to the hypothesis that abnormal lysosome formation was related to events occurring at the Golgi level.	Heparitin Sulfate	159-161	N-acetyl-alpha-glucosaminidase	Homo sapiens	57-64
22300986-4	2012	First, PSA promotes interaction of NCAM with heparan sulfate proteoglycans and thus stimulates synaptogenesis.	Heparitin Sulfate	45-60	neural cell adhesion molecule 1	Homo sapiens	35-39
22411800-3	2012	To address this issue, we eliminated heparan sulfate from postnatal neurons by conditionally inactivating Ext1, the gene encoding an enzyme essential for heparan sulfate synthesis.	Heparitin Sulfate	37-52	exostosin glycosyltransferase 1	Mus musculus	106-110
22298785-9	2012	Our results suggest that the embryonic stem cells lacking both NDST1 and NDST2, expressing a very low sulfated heparan sulfate, can take the initial step toward differentiation into all three germ layers.	Heparitin Sulfate	111-126	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	63-68
22298785-9	2012	Our results suggest that the embryonic stem cells lacking both NDST1 and NDST2, expressing a very low sulfated heparan sulfate, can take the initial step toward differentiation into all three germ layers.	Heparitin Sulfate	111-126	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	73-78
22411800-3	2012	To address this issue, we eliminated heparan sulfate from postnatal neurons by conditionally inactivating Ext1, the gene encoding an enzyme essential for heparan sulfate synthesis.	Heparitin Sulfate	154-169	exostosin glycosyltransferase 1	Mus musculus	106-110
22302099-6	2012	Accordingly, KIN59 inhibited the binding of FGF2 to FGF receptor-1 (FGFR1), thus preventing the formation of productive heparan sulphate proteoglycan/FGF2/FGFR1 ternary complexes, without affecting heparin interaction.	Heparitin Sulfate	120-136	fibroblast growth factor 2	Mus musculus	44-48
22302099-6	2012	Accordingly, KIN59 inhibited the binding of FGF2 to FGF receptor-1 (FGFR1), thus preventing the formation of productive heparan sulphate proteoglycan/FGF2/FGFR1 ternary complexes, without affecting heparin interaction.	Heparitin Sulfate	120-136	fibroblast growth factor receptor 1	Mus musculus	52-66
22302099-6	2012	Accordingly, KIN59 inhibited the binding of FGF2 to FGF receptor-1 (FGFR1), thus preventing the formation of productive heparan sulphate proteoglycan/FGF2/FGFR1 ternary complexes, without affecting heparin interaction.	Heparitin Sulfate	120-136	fibroblast growth factor receptor 1	Mus musculus	68-73
22298771-0	2012	Organ-specific sulfation patterns of heparan sulfate generated by extracellular sulfatases Sulf1 and Sulf2 in mice.	Heparitin Sulfate	37-52	sulfatase 1	Mus musculus	91-96
22298773-0	2012	Heparan sulfate chains of syndecan-1 regulate ectodomain shedding.	Heparitin Sulfate	0-15	syndecan 1	Homo sapiens	26-36
22298773-6	2012	Regulation of shedding by heparan sulfate occurs in multiple cell types, for both syndecan-1 and syndecan-4 and in murine and human syndecans.	Heparitin Sulfate	26-41	syndecan 1	Mus musculus	82-92
22298773-6	2012	Regulation of shedding by heparan sulfate occurs in multiple cell types, for both syndecan-1 and syndecan-4 and in murine and human syndecans.	Heparitin Sulfate	26-41	syndecan 4	Mus musculus	97-107
22298773-8	2012	Enhanced shedding of syndecan-1 following loss of heparan sulfate is accompanied by a dramatic increase in core protein synthesis.	Heparitin Sulfate	50-65	syndecan 1	Homo sapiens	21-31
22298771-0	2012	Organ-specific sulfation patterns of heparan sulfate generated by extracellular sulfatases Sulf1 and Sulf2 in mice.	Heparitin Sulfate	37-52	sulfatase 2	Mus musculus	101-106
22298771-1	2012	Heparan sulfate endosulfatases Sulf1 and Sulf2 hydrolyze 6-O-sulfate in heparan sulfate, thereby regulating cellular signaling.	Heparitin Sulfate	72-87	sulfatase 1	Mus musculus	31-36
22298771-1	2012	Heparan sulfate endosulfatases Sulf1 and Sulf2 hydrolyze 6-O-sulfate in heparan sulfate, thereby regulating cellular signaling.	Heparitin Sulfate	72-87	sulfatase 2	Mus musculus	41-46
22298771-9	2012	Moreover, overall changes in heparan sulfate compositions were greater in Sulf1(-/-) mice than in Sulf2(-/-) mice despite lower levels of Sulf1 mRNA expression, suggesting predominant roles of Sulf1 in heparan sulfate desulfation and distinct regulation of Sulf activities in vivo.	Heparitin Sulfate	29-44	sulfatase 1	Mus musculus	74-79
22298771-10	2012	Sulf1 and Sulf2 mRNAs were differentially expressed in restricted types of cells in organs, and consequently, the sulfation patterns of heparan sulfate were locally and distinctly altered in Sulf1 and Sulf2 knock-out mice.	Heparitin Sulfate	136-151	sulfatase 1	Mus musculus	0-5
22298771-10	2012	Sulf1 and Sulf2 mRNAs were differentially expressed in restricted types of cells in organs, and consequently, the sulfation patterns of heparan sulfate were locally and distinctly altered in Sulf1 and Sulf2 knock-out mice.	Heparitin Sulfate	136-151	sulfatase 2	Mus musculus	10-15
22298771-10	2012	Sulf1 and Sulf2 mRNAs were differentially expressed in restricted types of cells in organs, and consequently, the sulfation patterns of heparan sulfate were locally and distinctly altered in Sulf1 and Sulf2 knock-out mice.	Heparitin Sulfate	136-151	sulfatase 1	Mus musculus	191-196
22298771-10	2012	Sulf1 and Sulf2 mRNAs were differentially expressed in restricted types of cells in organs, and consequently, the sulfation patterns of heparan sulfate were locally and distinctly altered in Sulf1 and Sulf2 knock-out mice.	Heparitin Sulfate	136-151	sulfatase 2	Mus musculus	201-206
22298771-11	2012	These findings indicate that Sulf1 and Sulf2 differentially contribute to the generation of organ-specific sulfation patterns of heparan sulfate.	Heparitin Sulfate	129-144	sulfatase 1	Mus musculus	29-34
22298771-11	2012	These findings indicate that Sulf1 and Sulf2 differentially contribute to the generation of organ-specific sulfation patterns of heparan sulfate.	Heparitin Sulfate	129-144	sulfatase 2	Mus musculus	39-44
22266517-1	2012	PURPOSE: To elucidate the role of perlecan (Hspg2), a large multidomain heparan sulfate proteoglycan expressed in the basement membrane, in the structure of the corneal epithelium.	Heparitin Sulfate	72-87	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	44-49
22234688-4	2012	It has a high affinity for glycosaminoglycans, such as heparan sulfates, which potentiate its activity toward thrombin and target it to the pericellular space.	Heparitin Sulfate	55-71	coagulation factor II	Mus musculus	110-118
22234330-0	2012	Substrate inhibition and allosteric regulation by heparan sulfate of Trypanosoma brucei cathepsin L.	Heparitin Sulfate	50-65	cathepsin L	Homo sapiens	88-99
22267482-6	2012	Accordingly, TSG-6 prevents FGF2/PTX3 interaction and suppresses the inhibition exerted by PTX3 on heparan sulfate proteoglycan/FGF2/FGF receptor complex formation and on FGF2-dependent angiogenesis in vitro and in vivo.	Heparitin Sulfate	99-114	tumor necrosis factor alpha induced protein 6	Mus musculus	13-18
22267482-6	2012	Accordingly, TSG-6 prevents FGF2/PTX3 interaction and suppresses the inhibition exerted by PTX3 on heparan sulfate proteoglycan/FGF2/FGF receptor complex formation and on FGF2-dependent angiogenesis in vitro and in vivo.	Heparitin Sulfate	99-114	pentraxin related gene	Mus musculus	91-95
22415220-1	2012	Glypican-5 (GPC5) is a cell surface heparan sulfate proteoglycan and 1 of 6 closely related members of the glypican family in mammals.	Heparitin Sulfate	36-51	glypican 5	Homo sapiens	0-10
22415220-1	2012	Glypican-5 (GPC5) is a cell surface heparan sulfate proteoglycan and 1 of 6 closely related members of the glypican family in mammals.	Heparitin Sulfate	36-51	glypican 5	Homo sapiens	12-16
22234330-5	2012	Enzyme inhibition by the di-peptydyl substrate impaired the degradation of human fibrinogen at 25 C, but not at 37 C. We also found that heparan sulfate acts as a natural allosteric modulator of the enzyme through interactions that prevent substrate inhibition.	Heparitin Sulfate	137-152	fibrinogen beta chain	Homo sapiens	81-91
21953583-1	2012	OBJECTIVE: CXCL12gamma is an alternative splicing isoform of CXCL12 with enhanced affinity for heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	95-110	C-X-C motif chemokine ligand 12	Homo sapiens	11-17
21847613-0	2012	Autoantibodies from patients with celiac disease inhibit transglutaminase 2 binding to heparin/heparan sulfate and interfere with intestinal epithelial cell adhesion.	Heparitin Sulfate	95-110	transglutaminase 2	Homo sapiens	57-75
21847613-2	2012	Our objective was to study whether autoantibodies could modulate TG2 binding to heparin/heparan sulfate (HS) and intestinal epithelial cell attachment to fibronectin-TG2 matrix.	Heparitin Sulfate	88-103	transglutaminase 2	Homo sapiens	65-68
22230891-3	2012	We previously reported that N-sulfated heparan sulfates (N-sulfated HS) present in specialized extracellular matrix structures (fractones) and vascular basement membranes bind the neurogenic factor FGF-2 (fibroblast growth factor-2) next to stem cells in the anterior SVZ of the lateral ventricle, the most neurogenic zone in adulthood.	Heparitin Sulfate	39-55	fibroblast growth factor 2	Mus musculus	198-203
22230891-3	2012	We previously reported that N-sulfated heparan sulfates (N-sulfated HS) present in specialized extracellular matrix structures (fractones) and vascular basement membranes bind the neurogenic factor FGF-2 (fibroblast growth factor-2) next to stem cells in the anterior SVZ of the lateral ventricle, the most neurogenic zone in adulthood.	Heparitin Sulfate	39-55	fibroblast growth factor 2	Mus musculus	205-231
21953583-1	2012	OBJECTIVE: CXCL12gamma is an alternative splicing isoform of CXCL12 with enhanced affinity for heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	95-110	C-X-C motif chemokine ligand 12	Homo sapiens	61-67
21606942-2	2012	Our laboratory recently demonstrated that the availability of IL-2 is regulated, in part, by association with perlecan, a heparan sulfate proteoglycan.	Heparitin Sulfate	122-137	interleukin 2	Homo sapiens	62-66
22173227-2	2012	Syndecan-1 (Sdc-1) is a cell surface heparan sulfate proteoglycan that displays the capacity to modulate inflammatory processes within the vascular wall.	Heparitin Sulfate	37-52	syndecan 1	Homo sapiens	0-10
22173227-2	2012	Syndecan-1 (Sdc-1) is a cell surface heparan sulfate proteoglycan that displays the capacity to modulate inflammatory processes within the vascular wall.	Heparitin Sulfate	37-52	syndecan 1	Homo sapiens	12-17
22116097-1	2012	OBJECTIVE: Heparanase is an endoglycosidase that specifically cleaves carbohydrate chains of heparan sulfate.	Heparitin Sulfate	93-108	heparanase	Bos taurus	11-21
22116097-7	2012	Nuclear heparanase promoted cleavage of heparan sulfate, a potent inhibitor of histone acetyltransferase activity and gene transcription.	Heparitin Sulfate	40-55	heparanase	Bos taurus	8-18
21948871-6	2012	An overlay binding assay revealed that ZG16p binds specifically to heparan sulfate PGs by recognizing their GAG chains.	Heparitin Sulfate	67-82	zymogen granule protein 16	Rattus norvegicus	39-44
21948871-9	2012	These observations suggest that ZG16p is the primary binding partner of the granule heparan sulfate PGs.	Heparitin Sulfate	84-99	zymogen granule protein 16	Rattus norvegicus	32-37
21948871-10	2012	ZG16p may cross-link the granule heparan sulfate chains via two CBSs and facilitate the formation of a submembranous matrix, a sorting platform for enzyme proteins on the luminal side of the zymogen granule membrane.	Heparitin Sulfate	33-48	zymogen granule protein 16	Rattus norvegicus	0-5
22004282-0	2012	Heparan sulfate affects elastin deposition in fibroblasts cultured from donors of different ages.	Heparitin Sulfate	0-15	elastin	Homo sapiens	24-31
22284360-0	2012	A synthetic heparan sulfate-mimetic peptide conjugated to a mini CD4 displays very high anti- HIV-1 activity independently of coreceptor usage.	Heparitin Sulfate	12-27	CD4 molecule	Homo sapiens	65-68
22284360-3	2012	To pierce this defense mechanism, we engineered a series of heparan sulfate mimicking tridecapeptides and showed that one of them target the gp120 coreceptor binding site with muM affinity.	Heparitin Sulfate	60-75	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	141-146
22284360-3	2012	To pierce this defense mechanism, we engineered a series of heparan sulfate mimicking tridecapeptides and showed that one of them target the gp120 coreceptor binding site with muM affinity.	Heparitin Sulfate	60-75	latexin	Homo sapiens	176-179
22004282-3	2012	In particular, we have recently shown that HS is present inside elastic fibers and plays a role in the assembly and stability of elastin coacervates.	Heparitin Sulfate	43-45	elastin	Homo sapiens	129-136
22037484-3	2012	EXT1 and EXT2 are both tumor suppressor genes encoding proteins that function as glycosyltransferases, catalyzing the biosynthesis of heparan sulfate.	Heparitin Sulfate	134-149	exostosin glycosyltransferase 1	Homo sapiens	0-4
22169133-1	2012	Heparanase is a heparan sulfate degrading endoglycosidase.	Heparitin Sulfate	16-31	heparanase	Mus musculus	0-10
22037484-3	2012	EXT1 and EXT2 are both tumor suppressor genes encoding proteins that function as glycosyltransferases, catalyzing the biosynthesis of heparan sulfate.	Heparitin Sulfate	134-149	exostosin glycosyltransferase 2	Homo sapiens	9-13
22102278-3	2012	Because the interaction between FGF-2 and its receptor is mediated by heparan sulfate (HS) and syndecans, we speculated that a deranged HS/syndecans regulation impairs FGF-2 activity.	Heparitin Sulfate	70-85	fibroblast growth factor 2	Homo sapiens	32-37
22134915-6	2012	Heparan sulfate was also capable of inducing glyceraldehyde-3-phosphate dehydrogenase aggregation, but chondroitin sulfates A, B, and C together with dextran sulfate had a negligible effect.	Heparitin Sulfate	0-15	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	45-85
22102278-3	2012	Because the interaction between FGF-2 and its receptor is mediated by heparan sulfate (HS) and syndecans, we speculated that a deranged HS/syndecans regulation impairs FGF-2 activity.	Heparitin Sulfate	70-85	fibroblast growth factor 2	Homo sapiens	168-173
22102278-3	2012	Because the interaction between FGF-2 and its receptor is mediated by heparan sulfate (HS) and syndecans, we speculated that a deranged HS/syndecans regulation impairs FGF-2 activity.	Heparitin Sulfate	87-89	fibroblast growth factor 2	Homo sapiens	32-37
22102278-3	2012	Because the interaction between FGF-2 and its receptor is mediated by heparan sulfate (HS) and syndecans, we speculated that a deranged HS/syndecans regulation impairs FGF-2 activity.	Heparitin Sulfate	87-89	fibroblast growth factor 2	Homo sapiens	168-173
22085638-6	2012	These results further demonstrate that while IL-7 is principally a heparin/heparan sulfate binding protein, it also interacts with dermatan sulfate, chondroitin sulfates C, D, and E, indicating that this cytokine preferentially interacts with GAGs having a higher degree of sulfation.	Heparitin Sulfate	75-90	interleukin 7	Mus musculus	45-49
22005328-1	2012	The objective of this study was to investigate the effect of heparin sulfate groups on the osteogenic activity of bone morphogenetic protein-2 (BMP-2) in vitro and in vivo.	Heparitin Sulfate	61-76	bone morphogenetic protein 2	Rattus norvegicus	114-142
22005328-1	2012	The objective of this study was to investigate the effect of heparin sulfate groups on the osteogenic activity of bone morphogenetic protein-2 (BMP-2) in vitro and in vivo.	Heparitin Sulfate	61-76	bone morphogenetic protein 2	Rattus norvegicus	144-149
22396159-2	2012	Compared to the members of paracrine FGF subfamiles, the three members of the FGF19 subfamily, namely FGF19, FGF21 and FGF23, have poor affinity for heparan sulfate (HS) and therefore can diffuse freely in the HS-rich extracellular matrix to enter into the bloodstream.	Heparitin Sulfate	149-164	fibroblast growth factor 19	Homo sapiens	78-83
22396159-2	2012	Compared to the members of paracrine FGF subfamiles, the three members of the FGF19 subfamily, namely FGF19, FGF21 and FGF23, have poor affinity for heparan sulfate (HS) and therefore can diffuse freely in the HS-rich extracellular matrix to enter into the bloodstream.	Heparitin Sulfate	149-164	fibroblast growth factor 19	Homo sapiens	102-107
22396159-2	2012	Compared to the members of paracrine FGF subfamiles, the three members of the FGF19 subfamily, namely FGF19, FGF21 and FGF23, have poor affinity for heparan sulfate (HS) and therefore can diffuse freely in the HS-rich extracellular matrix to enter into the bloodstream.	Heparitin Sulfate	149-164	fibroblast growth factor 21	Homo sapiens	109-114
22396159-2	2012	Compared to the members of paracrine FGF subfamiles, the three members of the FGF19 subfamily, namely FGF19, FGF21 and FGF23, have poor affinity for heparan sulfate (HS) and therefore can diffuse freely in the HS-rich extracellular matrix to enter into the bloodstream.	Heparitin Sulfate	149-164	fibroblast growth factor 23	Homo sapiens	119-124
22396159-2	2012	Compared to the members of paracrine FGF subfamiles, the three members of the FGF19 subfamily, namely FGF19, FGF21 and FGF23, have poor affinity for heparan sulfate (HS) and therefore can diffuse freely in the HS-rich extracellular matrix to enter into the bloodstream.	Heparitin Sulfate	166-168	fibroblast growth factor 19	Homo sapiens	78-83
22396159-2	2012	Compared to the members of paracrine FGF subfamiles, the three members of the FGF19 subfamily, namely FGF19, FGF21 and FGF23, have poor affinity for heparan sulfate (HS) and therefore can diffuse freely in the HS-rich extracellular matrix to enter into the bloodstream.	Heparitin Sulfate	166-168	fibroblast growth factor 19	Homo sapiens	102-107
22396159-2	2012	Compared to the members of paracrine FGF subfamiles, the three members of the FGF19 subfamily, namely FGF19, FGF21 and FGF23, have poor affinity for heparan sulfate (HS) and therefore can diffuse freely in the HS-rich extracellular matrix to enter into the bloodstream.	Heparitin Sulfate	166-168	fibroblast growth factor 21	Homo sapiens	109-114
22396159-2	2012	Compared to the members of paracrine FGF subfamiles, the three members of the FGF19 subfamily, namely FGF19, FGF21 and FGF23, have poor affinity for heparan sulfate (HS) and therefore can diffuse freely in the HS-rich extracellular matrix to enter into the bloodstream.	Heparitin Sulfate	166-168	fibroblast growth factor 23	Homo sapiens	119-124
22339633-1	2012	Heparan sulfate (HS) and heparan sulfate proteoglycans (HSPG) play a significant role in brain development, and their structural and quantitative changes are revealed during aging and in neurodegenerative disorders.	Heparitin Sulfate	25-40	syndecan 2	Rattus norvegicus	56-60
22396159-8	2012	The distinct topologies of the HBS of FGF19 and FGF23 prevent HS from direct hydrogen bonding with the backbone atoms of the HBS of these ligands and accordingly decrease the HS binding affinity of this subfamily.	Heparitin Sulfate	62-64	fibroblast growth factor 19	Homo sapiens	38-43
22396159-8	2012	The distinct topologies of the HBS of FGF19 and FGF23 prevent HS from direct hydrogen bonding with the backbone atoms of the HBS of these ligands and accordingly decrease the HS binding affinity of this subfamily.	Heparitin Sulfate	62-64	fibroblast growth factor 23	Homo sapiens	48-53
21963444-3	2012	Initial testing in a mixed neural cell culture model demonstrated that the vector could significantly increase SGSH activity in transduced cells, resulting in near-normalization of heparan sulfate-derived fragments.	Heparitin Sulfate	181-196	N-sulfoglucosamine sulfohydrolase	Homo sapiens	111-115
21963444-1	2012	Mucopolysaccharidosis type IIIA (MPS-IIIA) is a severe neurodegenerative lysosomal storage disorder caused by a deficiency of N-sulfoglucosamine sulfohydrolase (SGSH) activity with subsequent accumulation of partially-degraded heparan sulfate and other glycolipids.	Heparitin Sulfate	227-242	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-31
22466566-1	2012	Natural cytotoxicity receptor 2 (NCR2 or natural killer (NK)p44) and NCR3 (NKp30) bind to heparin and heparin sulfate; however, other natural ligands have yet to be identified.	Heparitin Sulfate	102-117	natural cytotoxicity triggering receptor 2	Homo sapiens	33-37
22466566-1	2012	Natural cytotoxicity receptor 2 (NCR2 or natural killer (NK)p44) and NCR3 (NKp30) bind to heparin and heparin sulfate; however, other natural ligands have yet to be identified.	Heparitin Sulfate	102-117	natural cytotoxicity triggering receptor 2	Homo sapiens	41-63
22466566-1	2012	Natural cytotoxicity receptor 2 (NCR2 or natural killer (NK)p44) and NCR3 (NKp30) bind to heparin and heparin sulfate; however, other natural ligands have yet to be identified.	Heparitin Sulfate	102-117	natural cytotoxicity triggering receptor 3	Homo sapiens	69-73
22466566-1	2012	Natural cytotoxicity receptor 2 (NCR2 or natural killer (NK)p44) and NCR3 (NKp30) bind to heparin and heparin sulfate; however, other natural ligands have yet to be identified.	Heparitin Sulfate	102-117	natural cytotoxicity triggering receptor 3	Homo sapiens	75-80
22214369-7	2012	The pro-alpha3(V) chain co-localized with heparan sulfate, which appeared in the skin after injury and might bind via an acidic segment of the pro-alpha3(V) chain.	Heparitin Sulfate	42-57	collagen, type V, alpha 3	Mus musculus	4-17
22214369-7	2012	The pro-alpha3(V) chain co-localized with heparan sulfate, which appeared in the skin after injury and might bind via an acidic segment of the pro-alpha3(V) chain.	Heparitin Sulfate	42-57	collagen, type V, alpha 3	Mus musculus	143-156
21963444-1	2012	Mucopolysaccharidosis type IIIA (MPS-IIIA) is a severe neurodegenerative lysosomal storage disorder caused by a deficiency of N-sulfoglucosamine sulfohydrolase (SGSH) activity with subsequent accumulation of partially-degraded heparan sulfate and other glycolipids.	Heparitin Sulfate	227-242	N-sulfoglucosamine sulfohydrolase	Homo sapiens	161-165
21956842-7	2012	Homozygous mutations of EXT1/EXT2 result in reduced synthesis and shortened heparan sulphate chains on both cell surface and matrix proteoglycans.	Heparitin Sulfate	76-92	exostosin glycosyltransferase 1	Homo sapiens	24-28
21898481-1	2012	UNLABELLED: We recently showed that the heparan sulfate proteoglycan syndecan-1 mediates hepatic clearance of triglyceride-rich lipoproteins in mice based on systemic deletion of syndecan-1 and hepatocyte-specific inactivation of sulfotransferases involved in heparan sulfate biosynthesis.	Heparitin Sulfate	40-55	syndecan 1	Mus musculus	69-79
21898481-1	2012	UNLABELLED: We recently showed that the heparan sulfate proteoglycan syndecan-1 mediates hepatic clearance of triglyceride-rich lipoproteins in mice based on systemic deletion of syndecan-1 and hepatocyte-specific inactivation of sulfotransferases involved in heparan sulfate biosynthesis.	Heparitin Sulfate	40-55	syndecan 1	Mus musculus	179-189
22885958-0	2012	Detection and characterization of syndecan-1-associated heparan sulfate 6-O-sulfated motifs overexpressed in multiple myeloma cells using single chain antibody variable fragments.	Heparitin Sulfate	56-71	syndecan 1	Homo sapiens	34-44
22885958-4	2012	Both D4A4 and D6B10 scFvs immunoprecipitated syndecan-1 from myeloma cells and recognized sulfated motifs on syndecan-1-associated heparan sulfate (HS) chains.	Heparitin Sulfate	131-146	syndecan 1	Homo sapiens	109-119
22885958-4	2012	Both D4A4 and D6B10 scFvs immunoprecipitated syndecan-1 from myeloma cells and recognized sulfated motifs on syndecan-1-associated heparan sulfate (HS) chains.	Heparitin Sulfate	148-150	syndecan 1	Homo sapiens	109-119
21956842-7	2012	Homozygous mutations of EXT1/EXT2 result in reduced synthesis and shortened heparan sulphate chains on both cell surface and matrix proteoglycans.	Heparitin Sulfate	76-92	exostosin glycosyltransferase 2	Homo sapiens	29-33
22773903-2	2012	Heparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains, which can induce VEGF expression.	Heparitin Sulfate	59-74	vascular endothelial growth factor A	Mus musculus	105-109
22252637-1	2012	Serglycin is a proteoglycan composed of a relatively small (~17 kDa) core protein to which sulfated glycosaminoglycans of either heparin, heparan sulfate or chondroitin sulfate types are attached.	Heparitin Sulfate	138-153	serglycin	Mus musculus	0-9
22275804-10	2012	While digestion was more pronounced in the WT group, double digestion with Keratanase I and Chondroitinase ABC removed 88% of the GAG filaments in the WT, compared to 72% of those in the P2X(7) (-/-) mice, indicating that there are more heparan sulfate proteoglycans in the latter.	Heparitin Sulfate	237-252	galactosamine (N-acetyl)-6-sulfate sulfatase	Mus musculus	75-106
22057033-9	2012	The heparan sulfate products detected in the follicles are likely to be associated with perlecan, collagen XVIII or betaglycan.	Heparitin Sulfate	4-19	transforming growth factor, beta receptor III	Mus musculus	116-126
23300607-3	2012	Thus, the anti-metastatic activity of PG545 has been linked to the enzymatic function of heparanase - the only endoglycosidase known to cleave HS, an important component of the extracellular matrix (ECM) which represents a potential avenue for therapeutic intervention for certain metastatic cancer indications.	Heparitin Sulfate	143-145	heparanase	Mus musculus	89-99
23284911-7	2012	We found that elevated expression of heparanase by high glucose was associated with increased shedding of heparan sulfate (DeltaHS) and the tight junction protein occludin.	Heparitin Sulfate	106-121	heparanase	Homo sapiens	37-47
23152789-2	2012	BACKGROUND: The antithrombin-heparin/heparan sulfate (H/HS) and thrombin-H/HS interactions are recognized as prototypic specific and non-specific glycosaminoglycan (GAG)-protein interactions, respectively.	Heparitin Sulfate	37-52	serpin family C member 1	Homo sapiens	16-28
23251556-1	2012	T5 is a novel splice variant of heparanase, an endo-beta-D-glucuronidase capable of cleaving heparan sulfate side chains at a limited number of sites.	Heparitin Sulfate	93-108	glucuronidase beta	Homo sapiens	52-72
23152789-2	2012	BACKGROUND: The antithrombin-heparin/heparan sulfate (H/HS) and thrombin-H/HS interactions are recognized as prototypic specific and non-specific glycosaminoglycan (GAG)-protein interactions, respectively.	Heparitin Sulfate	37-52	coagulation factor II, thrombin	Homo sapiens	20-28
23152853-0	2012	ScFv anti-heparan sulfate antibodies unexpectedly activate endothelial and cancer cells through p38 MAPK: implications for antibody-based targeting of heparan sulfate proteoglycans in cancer.	Heparitin Sulfate	10-25	immunglobulin heavy chain variable region	Homo sapiens	0-4
23028487-1	2012	Heparanase is an endo-beta-glucuronidase that cleaves heparan sulfate side chains, leading to structural modifications that loosen the extracellular matrix barrier and associated with tumor metastasis, inflammation and angiogenesis.	Heparitin Sulfate	54-69	heparanase	Homo sapiens	0-10
23152853-0	2012	ScFv anti-heparan sulfate antibodies unexpectedly activate endothelial and cancer cells through p38 MAPK: implications for antibody-based targeting of heparan sulfate proteoglycans in cancer.	Heparitin Sulfate	10-25	p38b MAP kinase	Drosophila melanogaster	96-99
23133647-0	2012	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	Heparitin Sulfate	106-121	fibrillin 1	Homo sapiens	0-11
23133647-7	2012	This finding enabled us to map heparin/heparan sulfate binding to two sites on fibrillin-1 TB5 using a mutagenesis approach.	Heparitin Sulfate	39-54	fibrillin 1	Homo sapiens	79-90
23133647-7	2012	This finding enabled us to map heparin/heparan sulfate binding to two sites on fibrillin-1 TB5 using a mutagenesis approach.	Heparitin Sulfate	39-54	transforming growth factor beta regulator 1	Homo sapiens	91-94
23028487-1	2012	Heparanase is an endo-beta-glucuronidase that cleaves heparan sulfate side chains, leading to structural modifications that loosen the extracellular matrix barrier and associated with tumor metastasis, inflammation and angiogenesis.	Heparitin Sulfate	54-69	glucuronidase beta	Homo sapiens	22-40
22916091-2	2012	A series of heparan sulfate mimetic small molecules targeting VEGF/VEGFR pathway has been synthesized.	Heparitin Sulfate	12-27	vascular endothelial growth factor A	Mus musculus	62-66
22479599-2	2012	Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate proteoglycan.	Heparitin Sulfate	88-103	agouti related neuropeptide	Mus musculus	11-33
22848466-7	2012	Here we show that stromal fibroblasts with a mutation in the heparan sulfate elongating enzyme Ext1 and thus a low heparan sulfate content, formed composite fibroblast/tumor cell spheroids with a significant lower interstitial fluid pressure than corresponding wild-type fibroblast/tumor cell composite spheroids.	Heparitin Sulfate	61-76	exostosin glycosyltransferase 1	Homo sapiens	95-99
22848466-7	2012	Here we show that stromal fibroblasts with a mutation in the heparan sulfate elongating enzyme Ext1 and thus a low heparan sulfate content, formed composite fibroblast/tumor cell spheroids with a significant lower interstitial fluid pressure than corresponding wild-type fibroblast/tumor cell composite spheroids.	Heparitin Sulfate	115-130	exostosin glycosyltransferase 1	Homo sapiens	95-99
22479599-2	2012	Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate proteoglycan.	Heparitin Sulfate	88-103	melanocortin 4 receptor	Mus musculus	44-48
22479599-2	2012	Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate proteoglycan.	Heparitin Sulfate	88-103	agouti related neuropeptide	Mus musculus	35-39
22479599-2	2012	Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate proteoglycan.	Heparitin Sulfate	88-103	syndecan 3	Mus musculus	74-84
21979436-9	2011	CONCLUSIONS: Heparin releases sFlt1 by displacing the sFlt1 heparin-binding site from heparan sulfate proteoglycans.	Heparitin Sulfate	86-101	FMS-like tyrosine kinase 1	Mus musculus	30-35
22479599-9	2012	Our data indicate that heparanase acts as a negative modulator of AgRP signaling at MC4R, through cleavage of heparan sulfate chains presumably linked to syndecan-3.	Heparitin Sulfate	110-125	agouti related neuropeptide	Mus musculus	66-70
22396758-10	2012	CONCLUSIONS/SIGNIFICANCE: Both syndecan-1 and syndecan-4 have been found to specifically associate with membrane rafts and their association seemed independent of intact HS chains.	Heparitin Sulfate	170-172	syndecan 1	Rattus norvegicus	31-41
22396758-10	2012	CONCLUSIONS/SIGNIFICANCE: Both syndecan-1 and syndecan-4 have been found to specifically associate with membrane rafts and their association seemed independent of intact HS chains.	Heparitin Sulfate	170-172	syndecan 4	Rattus norvegicus	46-56
22049073-0	2011	Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.	Heparitin Sulfate	22-37	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	66-100
22049073-1	2011	Deficiency of the heparan sulfate biosynthesis enzyme N-deacetylase/N-sulfotransferase 1 (NDST1) in mice causes severely disturbed heparan sulfate biosynthesis in all organs, whereas lack of NDST2 only affects heparin biosynthesis in mast cells (MCs).	Heparitin Sulfate	18-33	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	54-88
22049073-1	2011	Deficiency of the heparan sulfate biosynthesis enzyme N-deacetylase/N-sulfotransferase 1 (NDST1) in mice causes severely disturbed heparan sulfate biosynthesis in all organs, whereas lack of NDST2 only affects heparin biosynthesis in mast cells (MCs).	Heparitin Sulfate	18-33	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	90-95
22049073-1	2011	Deficiency of the heparan sulfate biosynthesis enzyme N-deacetylase/N-sulfotransferase 1 (NDST1) in mice causes severely disturbed heparan sulfate biosynthesis in all organs, whereas lack of NDST2 only affects heparin biosynthesis in mast cells (MCs).	Heparitin Sulfate	18-33	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	191-196
22049073-1	2011	Deficiency of the heparan sulfate biosynthesis enzyme N-deacetylase/N-sulfotransferase 1 (NDST1) in mice causes severely disturbed heparan sulfate biosynthesis in all organs, whereas lack of NDST2 only affects heparin biosynthesis in mast cells (MCs).	Heparitin Sulfate	131-146	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	54-88
22049073-1	2011	Deficiency of the heparan sulfate biosynthesis enzyme N-deacetylase/N-sulfotransferase 1 (NDST1) in mice causes severely disturbed heparan sulfate biosynthesis in all organs, whereas lack of NDST2 only affects heparin biosynthesis in mast cells (MCs).	Heparitin Sulfate	131-146	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	90-95
22049079-0	2011	Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions.	Heparitin Sulfate	49-64	sonic hedgehog signaling molecule	Homo sapiens	22-36
22188870-0	2011	TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated.	Heparitin Sulfate	15-31	toll-like receptor 4	Mus musculus	0-4
22188870-0	2011	TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated.	Heparitin Sulfate	15-31	interferon regulatory factor 3	Mus musculus	76-80
22188870-2	2011	In the pancreas, syndecan-anchored heparan sulphate (HS) on the ductal epithelium can be cleaved off its protein cores by the proteases (trypsin and elastase) and potentially activate TLR4 signalling.	Heparitin Sulfate	35-51	toll-like receptor 4	Mus musculus	184-188
22188870-2	2011	In the pancreas, syndecan-anchored heparan sulphate (HS) on the ductal epithelium can be cleaved off its protein cores by the proteases (trypsin and elastase) and potentially activate TLR4 signalling.	Heparitin Sulfate	53-55	toll-like receptor 4	Mus musculus	184-188
22188870-9	2011	CONCLUSIONS: The results of this study show that HS is capable of initiating a TLR4-dependent innate immune response in the pancreas which is distinctly different from that induced by LPS.	Heparitin Sulfate	49-51	toll-like receptor 4	Mus musculus	79-83
22253766-4	2012	Mutations in two enzymes that are required during heparan sulphate synthesis (EXT1 or EXT2) are known to cause MO.	Heparitin Sulfate	50-66	exostosin glycosyltransferase 2	Danio rerio	86-90
21979436-9	2011	CONCLUSIONS: Heparin releases sFlt1 by displacing the sFlt1 heparin-binding site from heparan sulfate proteoglycans.	Heparitin Sulfate	86-101	FMS-like tyrosine kinase 1	Mus musculus	54-59
21696361-3	2011	FGF10 mediates biological responses by activating FGF receptor 2b (FGFR2b) with heparin/heparan sulfate in a paracrine manner.	Heparitin Sulfate	88-103	fibroblast growth factor 10	Mus musculus	0-5
21990362-0	2011	Heparan sulfate is essential for high mobility group protein 1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE).	Heparitin Sulfate	0-15	high mobility group protein B1	Cricetulus griseus	33-62
21990362-0	2011	Heparan sulfate is essential for high mobility group protein 1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE).	Heparitin Sulfate	0-15	LOC103159970	Cricetulus griseus	64-69
21990362-1	2011	In a proteomic search for heparan sulfate-binding proteins on monocytes, we identified HMGB1 (high mobility group protein B1).	Heparitin Sulfate	26-41	LOC103159970	Cricetulus griseus	87-92
21990362-1	2011	In a proteomic search for heparan sulfate-binding proteins on monocytes, we identified HMGB1 (high mobility group protein B1).	Heparitin Sulfate	26-41	LOC103159970	Cricetulus griseus	94-124
21990362-3	2011	Here, we report that the activity of HMGB1 depends on heparan sulfate.	Heparitin Sulfate	54-69	LOC103159970	Cricetulus griseus	37-42
21990362-4	2011	Binding and competition studies demonstrate that HMGB1 interacts with CHO and endothelial cell heparan sulfate.	Heparitin Sulfate	95-110	LOC103159970	Cricetulus griseus	49-54
21990362-5	2011	By site-directed mutagenesis, we identified a loop region that connects the A-box and B-box domains of HMGB1 as responsible for heparan sulfate binding.	Heparitin Sulfate	128-143	LOC103159970	Cricetulus griseus	103-108
21990362-6	2011	HMGB1-induced Erk1/2 and p38 phosphorylation is abolished when endothelial heparan sulfate is removed or blocked pharmacologically, resulting in decreased HMGB1-induced endothelial sprouting.	Heparitin Sulfate	75-90	LOC103159970	Cricetulus griseus	0-5
21990362-6	2011	HMGB1-induced Erk1/2 and p38 phosphorylation is abolished when endothelial heparan sulfate is removed or blocked pharmacologically, resulting in decreased HMGB1-induced endothelial sprouting.	Heparitin Sulfate	75-90	LOC103159970	Cricetulus griseus	155-160
21990362-7	2011	However, mutated HMGB1 that lacks the heparan sulfate-binding site retained its signaling activity.	Heparitin Sulfate	38-53	LOC103159970	Cricetulus griseus	17-22
21990362-8	2011	We show the major receptor for HMGB1, receptor for advanced glycation end products (RAGE), also binds to heparan sulfate and that RAGE and heparan sulfate forms a complex.	Heparitin Sulfate	105-120	LOC103159970	Cricetulus griseus	31-36
21990362-8	2011	We show the major receptor for HMGB1, receptor for advanced glycation end products (RAGE), also binds to heparan sulfate and that RAGE and heparan sulfate forms a complex.	Heparitin Sulfate	139-154	LOC103159970	Cricetulus griseus	31-36
21990362-9	2011	Our data establishes that the functional receptor for HMGB1 consists of a complex of RAGE and cell surface heparan sulfate.	Heparitin Sulfate	107-122	LOC103159970	Cricetulus griseus	54-59
22072576-1	2011	In Xenopus laevis embryos, heparanase, the enzyme that degrades heparan sulfate, is synthesized as a preproheparanase (XHpaL) and processed to become enzymatically active (XHpa active).	Heparitin Sulfate	64-79	heparanase L homeolog	Xenopus laevis	27-37
22082664-2	2011	AGRIN is a heparan sulfate proteoglycan found abundantly in basement membranes of the cerebral vasculature, where it has been proposed to serve a functional role in the BBB.	Heparitin Sulfate	11-26	agrin	Mus musculus	0-5
22009724-2	2011	Heparanase, an endoglycosidase capable of degrading heparan sulfate, a major polysaccharide constituent of the ECM, is implicated in diverse processes associated with ECM remodeling, such as morphogenesis, angiogenesis, and tumor invasion.	Heparitin Sulfate	52-67	heparanase	Rattus norvegicus	0-10
21538184-2	2011	TLR4 is activated by lipopolysaccharide (LPS) but also by products of matrix degradation such as hyaluronic acid and heparan sulfate.	Heparitin Sulfate	117-132	toll like receptor 4	Homo sapiens	0-4
21538184-7	2011	Tumor necrosis factor-alpha production induced by the TLR4 ligands LPS, hyaluronic acid, and heparan sulfate was potently inhibited by Ado (-75% for LPS, P &lt; 0.005).	Heparitin Sulfate	93-108	tumor necrosis factor	Homo sapiens	0-27
21538184-7	2011	Tumor necrosis factor-alpha production induced by the TLR4 ligands LPS, hyaluronic acid, and heparan sulfate was potently inhibited by Ado (-75% for LPS, P &lt; 0.005).	Heparitin Sulfate	93-108	toll like receptor 4	Homo sapiens	54-58
22082664-3	2011	Furthermore, AGRIN is the major heparan sulfate proteoglycan associated with amyloid plaques in AD brains.	Heparitin Sulfate	32-47	agrin	Mus musculus	13-18
21932778-9	2011	In summary, we have found that the potential N-glycosylation sites in glypican-1 are invariably occupied and that the N-linked glycans on glypican-1 affect protein expression and heparan sulfate substitution but that correct folding can be obtained in the absence of N-linked glycans.	Heparitin Sulfate	179-194	glypican 1	Homo sapiens	138-148
22111880-1	2011	BACKGROUND: Fibroblast growth factors FGF-1 and FGF-2 are often upregulated in tumors, but tightly bound to heparan sulphate proteoglycans of the extracellular matrix (ECM).	Heparitin Sulfate	108-124	fibroblast growth factor 1	Mus musculus	38-43
22111880-1	2011	BACKGROUND: Fibroblast growth factors FGF-1 and FGF-2 are often upregulated in tumors, but tightly bound to heparan sulphate proteoglycans of the extracellular matrix (ECM).	Heparitin Sulfate	108-124	fibroblast growth factor 2	Mus musculus	48-53
21910976-2	2011	MPS III results from a deficiency in one of the four enzymes involved in the heparan sulfate degradation, with sulfamidase (SGSH), alpha-N-acetylglucosaminidase (NAGLU), acetyl-coenzyme A: alpha-glucosaminide N-acetyltransferase (HGSNAT), and N-acetylglucosamine-6-sulfatase (GNS) being deficient respectively in MPS IIIA, MPS IIIB, MPS IIIC and MPS IIID.	Heparitin Sulfate	77-92	N-sulfoglucosamine sulfohydrolase	Homo sapiens	124-128
21910976-2	2011	MPS III results from a deficiency in one of the four enzymes involved in the heparan sulfate degradation, with sulfamidase (SGSH), alpha-N-acetylglucosaminidase (NAGLU), acetyl-coenzyme A: alpha-glucosaminide N-acetyltransferase (HGSNAT), and N-acetylglucosamine-6-sulfatase (GNS) being deficient respectively in MPS IIIA, MPS IIIB, MPS IIIC and MPS IIID.	Heparitin Sulfate	77-92	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	230-236
21910976-2	2011	MPS III results from a deficiency in one of the four enzymes involved in the heparan sulfate degradation, with sulfamidase (SGSH), alpha-N-acetylglucosaminidase (NAGLU), acetyl-coenzyme A: alpha-glucosaminide N-acetyltransferase (HGSNAT), and N-acetylglucosamine-6-sulfatase (GNS) being deficient respectively in MPS IIIA, MPS IIIB, MPS IIIC and MPS IIID.	Heparitin Sulfate	77-92	glucosamine (N-acetyl)-6-sulfatase	Homo sapiens	243-274
21910976-2	2011	MPS III results from a deficiency in one of the four enzymes involved in the heparan sulfate degradation, with sulfamidase (SGSH), alpha-N-acetylglucosaminidase (NAGLU), acetyl-coenzyme A: alpha-glucosaminide N-acetyltransferase (HGSNAT), and N-acetylglucosamine-6-sulfatase (GNS) being deficient respectively in MPS IIIA, MPS IIIB, MPS IIIC and MPS IIID.	Heparitin Sulfate	77-92	N-acetyl-alpha-glucosaminidase	Homo sapiens	323-331
22074387-1	2011	UNLABELLED: Mucopolysaccharidosis type I (MPS I) was a group of rare autosomal recessive disorder caused by the deficiency of the lysosomal enzyme, alpha -L -iduronidase, and the resulting accumulation of undergraded dematan sulfate and heparan sulfate.	Heparitin Sulfate	237-252	alpha-L-iduronidase	Homo sapiens	148-169
22025571-3	2011	METHODS: Keratocytes, isolated from rabbit corneal stroma, and cultured in a serum-free medium, pretreated or not treated with JNK inhibitor (SP600125), were activated with FGF-2/heparin sulfate (HS) or TGF-beta1 in the presence or absence of SP600125.	Heparitin Sulfate	179-194	fibroblast growth factor 2	Oryctolagus cuniculus	173-178
21949132-9	2011	Treatment with heparinase-III and p-nitrophenyl-beta-D-xylopyranoside (PNPX), an inhibitor of heparan sulfate synthesis and transfection with SDC4-shRNA partially blocked cytokine mediated aggrecan degradation.	Heparitin Sulfate	94-109	syndecan 4	Homo sapiens	142-146
21964526-0	2011	Serum heparan sulfate concentration is correlated with the failure of epidermal growth factor receptor tyrosine kinase inhibitor treatment in patients with lung adenocarcinoma.	Heparitin Sulfate	6-21	epidermal growth factor receptor	Homo sapiens	70-102
21964526-2	2011	We hypothesized that the serum concentration of heparan sulfate (HS), which activates oncogenic growth factor receptor signaling through EGFR and non-EGFR signaling pathways, may be a novel glycobiological biomarker for EGFR-TKIs treatment in NSCLC.	Heparitin Sulfate	48-63	epidermal growth factor receptor	Homo sapiens	137-141
21964526-2	2011	We hypothesized that the serum concentration of heparan sulfate (HS), which activates oncogenic growth factor receptor signaling through EGFR and non-EGFR signaling pathways, may be a novel glycobiological biomarker for EGFR-TKIs treatment in NSCLC.	Heparitin Sulfate	48-63	epidermal growth factor receptor	Homo sapiens	150-154
21964526-2	2011	We hypothesized that the serum concentration of heparan sulfate (HS), which activates oncogenic growth factor receptor signaling through EGFR and non-EGFR signaling pathways, may be a novel glycobiological biomarker for EGFR-TKIs treatment in NSCLC.	Heparitin Sulfate	48-63	epidermal growth factor receptor	Homo sapiens	150-154
21964526-2	2011	We hypothesized that the serum concentration of heparan sulfate (HS), which activates oncogenic growth factor receptor signaling through EGFR and non-EGFR signaling pathways, may be a novel glycobiological biomarker for EGFR-TKIs treatment in NSCLC.	Heparitin Sulfate	65-67	epidermal growth factor receptor	Homo sapiens	137-141
21964526-2	2011	We hypothesized that the serum concentration of heparan sulfate (HS), which activates oncogenic growth factor receptor signaling through EGFR and non-EGFR signaling pathways, may be a novel glycobiological biomarker for EGFR-TKIs treatment in NSCLC.	Heparitin Sulfate	65-67	epidermal growth factor receptor	Homo sapiens	150-154
21964526-2	2011	We hypothesized that the serum concentration of heparan sulfate (HS), which activates oncogenic growth factor receptor signaling through EGFR and non-EGFR signaling pathways, may be a novel glycobiological biomarker for EGFR-TKIs treatment in NSCLC.	Heparitin Sulfate	65-67	epidermal growth factor receptor	Homo sapiens	150-154
21497178-7	2011	Recent observations have demonstrated an anosmin-1 heparan sulphate dependent functional interaction with the product of the autosomal dominant KAL-2 (FGFR1: anosmin-2) gene, thereby modulating FGFR1 signalling.	Heparitin Sulfate	51-67	anosmin 1	Homo sapiens	41-50
21873421-2	2011	Using a murine model of MPSI Hurler (MPSIH), we have quantified the heparan sulfate (HS) accumulation resulting from alpha-l-iduronidase (Idua) deficiency.	Heparitin Sulfate	68-83	iduronidase, alpha-L	Mus musculus	117-136
21873421-2	2011	Using a murine model of MPSI Hurler (MPSIH), we have quantified the heparan sulfate (HS) accumulation resulting from alpha-l-iduronidase (Idua) deficiency.	Heparitin Sulfate	68-83	iduronidase, alpha-L	Mus musculus	138-142
21873421-2	2011	Using a murine model of MPSI Hurler (MPSIH), we have quantified the heparan sulfate (HS) accumulation resulting from alpha-l-iduronidase (Idua) deficiency.	Heparitin Sulfate	85-87	iduronidase, alpha-L	Mus musculus	117-136
21873421-2	2011	Using a murine model of MPSI Hurler (MPSIH), we have quantified the heparan sulfate (HS) accumulation resulting from alpha-l-iduronidase (Idua) deficiency.	Heparitin Sulfate	85-87	iduronidase, alpha-L	Mus musculus	138-142
21873421-3	2011	HS levels were significantly increased in liver and brain tissue from 12-week-old Idua(-/-) mice by 87- and 20-fold, respectively.	Heparitin Sulfate	0-2	iduronidase, alpha-L	Mus musculus	82-86
21873421-5	2011	Disaccharide compositional analyses also uncovered an HS disaccharide uniquely enriched in MPSIH, representing the terminal iduronic acid residue capping the non-reducing end of the HS chain, where no further degradation can occur in the absence of Idua.	Heparitin Sulfate	54-56	iduronidase, alpha-L	Mus musculus	249-253
21873421-6	2011	Critically, we identified that excess HS, some of which is colocalized to the Golgi secretory pathway, acts as a positive regulator of HS-sulfation, increasing the N-sulfotransferase activity of HS-modifying N-deacetylase/N-sulfotransferase enzymes.	Heparitin Sulfate	38-40	sulfotransferase family 1D, member 1	Mus musculus	164-182
21873421-6	2011	Critically, we identified that excess HS, some of which is colocalized to the Golgi secretory pathway, acts as a positive regulator of HS-sulfation, increasing the N-sulfotransferase activity of HS-modifying N-deacetylase/N-sulfotransferase enzymes.	Heparitin Sulfate	38-40	sulfotransferase family 1D, member 1	Mus musculus	222-240
21497178-7	2011	Recent observations have demonstrated an anosmin-1 heparan sulphate dependent functional interaction with the product of the autosomal dominant KAL-2 (FGFR1: anosmin-2) gene, thereby modulating FGFR1 signalling.	Heparitin Sulfate	51-67	fibroblast growth factor receptor 1	Homo sapiens	144-149
21497178-7	2011	Recent observations have demonstrated an anosmin-1 heparan sulphate dependent functional interaction with the product of the autosomal dominant KAL-2 (FGFR1: anosmin-2) gene, thereby modulating FGFR1 signalling.	Heparitin Sulfate	51-67	fibroblast growth factor receptor 1	Homo sapiens	151-156
21497178-7	2011	Recent observations have demonstrated an anosmin-1 heparan sulphate dependent functional interaction with the product of the autosomal dominant KAL-2 (FGFR1: anosmin-2) gene, thereby modulating FGFR1 signalling.	Heparitin Sulfate	51-67	fibroblast growth factor receptor 1	Homo sapiens	194-199
21855148-4	2011	We demonstrate a direct and dose-dependent binding of both nucleosomes and C1q to immortalized human glomerular endothelial cells (GEnC) in vitro, which in part is mediated by cell surface heparan sulfate.	Heparitin Sulfate	189-204	complement C1q A chain	Homo sapiens	75-78
21722266-9	2011	Furthermore, HSPG epitope analysis confirmed that HSulf-1 affected the structure of heparan sulfate on the cell surface.	Heparitin Sulfate	84-99	syndecan 2	Homo sapiens	13-17
20825431-1	2011	The Sanfilippo syndrome type C [mucopolysaccharidosis IIIC (MPS IIIC)] is caused by mutations in the HGSNAT gene, encoding an enzyme involved in heparan sulphate degradation.	Heparitin Sulfate	145-161	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	101-107
21874555-7	2011	Interactions between the tropoelastin and perlecan heparan sulfate chains were demonstrated using quartz crystal microbalance with dissipation solid phase binding studies.	Heparitin Sulfate	51-66	elastin	Homo sapiens	25-37
21874555-8	2011	Electrostatic interactions through the heparan sulfate chains of perlecan and core protein mediated the interactions with tropoelastin, and were both important in the coacervation of tropoelastin and deposition of elastin onto perlecan immobilized on the chip surface.	Heparitin Sulfate	39-54	elastin	Homo sapiens	122-134
21874555-8	2011	Electrostatic interactions through the heparan sulfate chains of perlecan and core protein mediated the interactions with tropoelastin, and were both important in the coacervation of tropoelastin and deposition of elastin onto perlecan immobilized on the chip surface.	Heparitin Sulfate	39-54	elastin	Homo sapiens	183-195
21874555-8	2011	Electrostatic interactions through the heparan sulfate chains of perlecan and core protein mediated the interactions with tropoelastin, and were both important in the coacervation of tropoelastin and deposition of elastin onto perlecan immobilized on the chip surface.	Heparitin Sulfate	39-54	elastin	Homo sapiens	127-134
22040554-2	2011	MO is caused by mutations in the EXT1 or EXT2 genes which encode glycosyltransferases implicated in heparin sulfate biosynthesis.	Heparitin Sulfate	100-115	exostosin glycosyltransferase 1	Homo sapiens	33-37
22040554-2	2011	MO is caused by mutations in the EXT1 or EXT2 genes which encode glycosyltransferases implicated in heparin sulfate biosynthesis.	Heparitin Sulfate	100-115	exostosin glycosyltransferase 2	Homo sapiens	41-45
21784848-11	2011	Compared with the classical mutations and the wild type, the group of neonatal mutations more severely affected the ability of fibrillin-1 to interact with heparin/heparan sulfate, which plays a role in microfibril assembly.	Heparitin Sulfate	164-179	fibrillin 1	Homo sapiens	127-138
21685203-3	2011	In this fatal lysosomal storage disease, defective alpha-N-acetylglucosaminidase interrupts the degradation of heparan sulfate (HS) proteoglycans and induces cell disorders predominating in the central nervous system, causing relentless progression toward severe mental retardation.	Heparitin Sulfate	111-126	N-acetyl-alpha-glucosaminidase	Homo sapiens	51-80
21685203-3	2011	In this fatal lysosomal storage disease, defective alpha-N-acetylglucosaminidase interrupts the degradation of heparan sulfate (HS) proteoglycans and induces cell disorders predominating in the central nervous system, causing relentless progression toward severe mental retardation.	Heparitin Sulfate	128-130	N-acetyl-alpha-glucosaminidase	Homo sapiens	51-80
21892940-3	2011	RESULTS: In this report we have studied Fgf, Wnt and Hedgehog (Hh) signaling in ext2 mutants, where heparan sulfate content is low.	Heparitin Sulfate	100-115	exostosin glycosyltransferase 2	Danio rerio	80-84
21803043-0	2011	Investigating the mechanism of the assembly of FGF1-binding heparan sulfate motifs.	Heparitin Sulfate	60-75	fibroblast growth factor 1	Homo sapiens	47-51
21572110-10	2011	The interaction of a hexamer of heparin sulfate was studied in interaction with fibroblast growth factor 2 and stromal cell-derived factor 1alpha.	Heparitin Sulfate	32-47	fibroblast growth factor 2	Homo sapiens	80-106
21757697-4	2011	Because syndecan-1 has heparan sulfate chains and because exogenous heparan sulfate has been shown to inhibit the activity of histone acetyltransferase (HAT) enzymes in vitro, we hypothesized that the reduction in nuclear syndecan-1 in cells expressing high levels of heparanase would result in increased HAT activity leading to stimulation of protein transcription.	Heparitin Sulfate	23-38	syndecan 1	Homo sapiens	8-18
21757697-4	2011	Because syndecan-1 has heparan sulfate chains and because exogenous heparan sulfate has been shown to inhibit the activity of histone acetyltransferase (HAT) enzymes in vitro, we hypothesized that the reduction in nuclear syndecan-1 in cells expressing high levels of heparanase would result in increased HAT activity leading to stimulation of protein transcription.	Heparitin Sulfate	68-83	syndecan 1	Homo sapiens	222-232
21537345-9	2011	The potential variation in the signaling range is characterized by an enhanced interaction with heparan sulfate for IHH with the E95K mutation, but not the E131K mutation.	Heparitin Sulfate	96-111	Indian hedgehog signaling molecule	Homo sapiens	116-119
21653700-3	2011	Here we report that hFGF19 at picomolar levels require sulfated glycosaminoglycans (sGAGs), such as heparan sulfate, heparin, and chondroitin sulfates, for its signaling via human FGFR4 in the presence of human betaKlotho.	Heparitin Sulfate	100-115	fibroblast growth factor 19	Homo sapiens	20-26
21743013-12	2011	The present study demonstrated that RGC axon projection toward the optic nerve head requires the expression of HS in the neural retina, suggesting that HS in the retina functions as an essential modulator of Netrin-1 and Slit-mediated intraretinal RGC axon guidance.	Heparitin Sulfate	111-113	netrin 1	Mus musculus	208-216
21743013-12	2011	The present study demonstrated that RGC axon projection toward the optic nerve head requires the expression of HS in the neural retina, suggesting that HS in the retina functions as an essential modulator of Netrin-1 and Slit-mediated intraretinal RGC axon guidance.	Heparitin Sulfate	152-154	netrin 1	Mus musculus	208-216
21642435-1	2011	Amyloid beta (Abeta) is generated from the copper- and heparan sulfate (HS)-binding amyloid precursor protein (APP) by proteolytic processing.	Heparitin Sulfate	55-70	amyloid beta precursor protein	Homo sapiens	84-109
21642435-1	2011	Amyloid beta (Abeta) is generated from the copper- and heparan sulfate (HS)-binding amyloid precursor protein (APP) by proteolytic processing.	Heparitin Sulfate	72-74	amyloid beta precursor protein	Homo sapiens	84-109
21642435-8	2011	anMan-containing HS oligo- and disaccharide preparations modulated or suppressed A11 immunoreactivity and oligomerization of Abeta42 peptide in an in vitro assay.	Heparitin Sulfate	17-19	DXS435E	Homo sapiens	81-84
21600196-3	2011	Sulfation of the GAG chain is key as evidenced by the renal agenesis phenotype in mice deficient in the HS biosynthetic enzyme, heparan sulfate 2-O sulfotransferase (Hs2st; an enzyme which catalyzes the 2-O-sulfation of uronic acids in heparan sulfate).	Heparitin Sulfate	128-143	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	166-171
21550404-1	2011	There is no treatment for the progressive neurodegenerative lysosomal storage disorder mucopolysaccharidosis type IIIA (MPS IIIA), which occurs due to a deficiency of functional N-sulfoglucosamine sulfohydrolase (SGSH), with subsequent accumulation of partially-degraded heparan sulfate and secondarily-stored compounds including GM2 and GM3 gangliosides and unesterified cholesterol.	Heparitin Sulfate	271-286	N-sulfoglucosamine sulfohydrolase	Canis lupus familiaris	213-217
21618584-1	2011	The accumulation of heparan sulfate (HS) in lysosomes is the primary consequence of the enzyme defect (alpha-N-acetylglucosaminidase) in mucopolysaccharidosis type IIIB.	Heparitin Sulfate	20-35	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	103-132
21618584-1	2011	The accumulation of heparan sulfate (HS) in lysosomes is the primary consequence of the enzyme defect (alpha-N-acetylglucosaminidase) in mucopolysaccharidosis type IIIB.	Heparitin Sulfate	37-39	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	103-132
21533889-3	2011	CCN2 acts via integrins and heparan sulfate-containing proteoglycans (HSPGs).	Heparitin Sulfate	28-43	cellular communication network factor 2	Mus musculus	0-4
21711246-4	2011	Heparan sulfate and integrins are also important modulators of VEGF signalling.	Heparitin Sulfate	0-15	vascular endothelial growth factor A	Homo sapiens	63-67
21539721-0	2011	Epac1 promotes melanoma metastasis via modification of heparan sulfate.	Heparitin Sulfate	55-70	Rap guanine nucleotide exchange factor 3	Homo sapiens	0-5
21539721-1	2011	Our previous report suggested the potential role of the exchange protein directly activated by cyclic AMP (Epac) in melanoma metastasis via heparan sulfate (HS)-mediated cell migration.	Heparitin Sulfate	140-155	Rap guanine nucleotide exchange factor 3	Homo sapiens	107-111
21539721-1	2011	Our previous report suggested the potential role of the exchange protein directly activated by cyclic AMP (Epac) in melanoma metastasis via heparan sulfate (HS)-mediated cell migration.	Heparitin Sulfate	157-159	Rap guanine nucleotide exchange factor 3	Homo sapiens	107-111
21539721-5	2011	Further, an Epac agonist increased, but ablation of Epac1 decreased, expressions of NDST-1, N-sulfated HS, and cell migration in various melanoma cell lines.	Heparitin Sulfate	103-105	Rap guanine nucleotide exchange factor 3	Homo sapiens	12-16
21539721-5	2011	Further, an Epac agonist increased, but ablation of Epac1 decreased, expressions of NDST-1, N-sulfated HS, and cell migration in various melanoma cell lines.	Heparitin Sulfate	103-105	Rap guanine nucleotide exchange factor 3	Homo sapiens	52-57
21493758-1	2011	AIMS: Glypican-3 (GPC3) is a membrane-bound heparan sulphate proteoglycan.	Heparitin Sulfate	44-60	glypican 3	Homo sapiens	6-16
21586278-2	2011	We recently provided in vivo evidence that inactivation of Ndst1, the predominant N-deacetylase/N-sulfotransferase gene essential for the formation of mature heparan sulfate, results in a highly specific defect in murine lobuloalveolar development (Crawford et al., 2010).	Heparitin Sulfate	158-173	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	59-64
21586278-2	2011	We recently provided in vivo evidence that inactivation of Ndst1, the predominant N-deacetylase/N-sulfotransferase gene essential for the formation of mature heparan sulfate, results in a highly specific defect in murine lobuloalveolar development (Crawford et al., 2010).	Heparitin Sulfate	158-173	sulfotransferase family 1D, member 1	Mus musculus	96-114
21586278-3	2011	Here, we demonstrate a highly penetrant dramatic defect in primary branching by mammary epithelial-specific inactivation of Ext1, a subunit of the copolymerase complex that catalyzes the formation of the heparan sulfate chain.	Heparitin Sulfate	204-219	exostosin glycosyltransferase 1	Homo sapiens	124-128
21586278-8	2011	When considered together with previous studies of Ndst1-deficient glands, the data presented here raise the possibility of partially-independent regulation by heparan sulfate-dependent pathways of primary ductal branching, terminal end bud bifurcation, secondary branching, ductal side-branching and lobuloalveolar formation.	Heparitin Sulfate	159-174	N-deacetylase and N-sulfotransferase 1	Homo sapiens	50-55
21719793-3	2011	Here, we found that the transcription factor Wilms" Tumor 1 (WT1) modulates VEGFA and FGF2 signaling by increasing the expression of the 6-O-endosulfatases Sulf1 and Sulf2, which remodel the heparan sulfate 6-O-sulfation pattern in the extracellular matrix.	Heparitin Sulfate	191-206	WT1 transcription factor	Mus musculus	45-59
21719793-3	2011	Here, we found that the transcription factor Wilms" Tumor 1 (WT1) modulates VEGFA and FGF2 signaling by increasing the expression of the 6-O-endosulfatases Sulf1 and Sulf2, which remodel the heparan sulfate 6-O-sulfation pattern in the extracellular matrix.	Heparitin Sulfate	191-206	WT1 transcription factor	Mus musculus	61-64
21719793-3	2011	Here, we found that the transcription factor Wilms" Tumor 1 (WT1) modulates VEGFA and FGF2 signaling by increasing the expression of the 6-O-endosulfatases Sulf1 and Sulf2, which remodel the heparan sulfate 6-O-sulfation pattern in the extracellular matrix.	Heparitin Sulfate	191-206	vascular endothelial growth factor A	Mus musculus	76-81
21719793-3	2011	Here, we found that the transcription factor Wilms" Tumor 1 (WT1) modulates VEGFA and FGF2 signaling by increasing the expression of the 6-O-endosulfatases Sulf1 and Sulf2, which remodel the heparan sulfate 6-O-sulfation pattern in the extracellular matrix.	Heparitin Sulfate	191-206	fibroblast growth factor 2	Mus musculus	86-90
21719793-3	2011	Here, we found that the transcription factor Wilms" Tumor 1 (WT1) modulates VEGFA and FGF2 signaling by increasing the expression of the 6-O-endosulfatases Sulf1 and Sulf2, which remodel the heparan sulfate 6-O-sulfation pattern in the extracellular matrix.	Heparitin Sulfate	191-206	sulfatase 1	Mus musculus	156-161
21719793-3	2011	Here, we found that the transcription factor Wilms" Tumor 1 (WT1) modulates VEGFA and FGF2 signaling by increasing the expression of the 6-O-endosulfatases Sulf1 and Sulf2, which remodel the heparan sulfate 6-O-sulfation pattern in the extracellular matrix.	Heparitin Sulfate	191-206	sulfatase 2	Mus musculus	166-171
21493758-1	2011	AIMS: Glypican-3 (GPC3) is a membrane-bound heparan sulphate proteoglycan.	Heparitin Sulfate	44-60	glypican 3	Homo sapiens	18-22
21536100-7	2011	Neuregulin-1 protein was produced in reticulocyte lysate at yields of 19 pmol/mL (~500 ng/mL); furthermore, it was potent at phosphorylating ErbB4 receptor and able to bind to heparin sulfate.	Heparitin Sulfate	176-191	neuregulin 1	Homo sapiens	0-12
21471524-5	2011	We demonstrate that C5-epimerase modification of heparan sulfate is critical for binding of a proliferation inducing ligand (APRIL) and that Glce-deficient plasma cells fail to respond to APRIL-mediated survival signals.	Heparitin Sulfate	49-64	TNF superfamily member 13	Homo sapiens	92-123
21505696-1	2011	Heparanase degrades heparan sulfate (HS) chains on proteoglycans; elevated levels of heparanase expression correlate with tumour cell metastatic potential and vascularity, and reduced post-operative survival of cancer patients.	Heparitin Sulfate	20-35	heparanase	Homo sapiens	0-10
21505696-1	2011	Heparanase degrades heparan sulfate (HS) chains on proteoglycans; elevated levels of heparanase expression correlate with tumour cell metastatic potential and vascularity, and reduced post-operative survival of cancer patients.	Heparitin Sulfate	37-39	heparanase	Homo sapiens	0-10
21505696-3	2011	Although several heparanase assays have been developed, most require the preparation of heterogeneous, (radio)labelled HS substrates and rely on the separation of enzymatically-degraded products on the basis of molecular size.	Heparitin Sulfate	119-121	heparanase	Homo sapiens	17-27
21471524-0	2011	Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.	Heparitin Sulfate	14-29	TNF superfamily member 13	Homo sapiens	87-92
21471524-3	2011	Modification of heparan sulfate by glucuronyl C5-epimerase (Glce) controls heparan sulfate-chain flexibility and thereby affects ligand binding.	Heparitin Sulfate	16-31	glucuronic acid epimerase	Homo sapiens	35-58
21621521-1	2011	Fibroblast growth factor receptor 1 (FGFR1) is known to be activated by homodimerization in the presence of both the FGF agonist ligand and heparan sulfate glycosaminoglycan.	Heparitin Sulfate	140-155	fibroblast growth factor receptor 1	Homo sapiens	0-35
21621521-1	2011	Fibroblast growth factor receptor 1 (FGFR1) is known to be activated by homodimerization in the presence of both the FGF agonist ligand and heparan sulfate glycosaminoglycan.	Heparitin Sulfate	140-155	fibroblast growth factor receptor 1	Homo sapiens	37-42
21471524-3	2011	Modification of heparan sulfate by glucuronyl C5-epimerase (Glce) controls heparan sulfate-chain flexibility and thereby affects ligand binding.	Heparitin Sulfate	16-31	glucuronic acid epimerase	Homo sapiens	60-64
21471524-5	2011	We demonstrate that C5-epimerase modification of heparan sulfate is critical for binding of a proliferation inducing ligand (APRIL) and that Glce-deficient plasma cells fail to respond to APRIL-mediated survival signals.	Heparitin Sulfate	49-64	TNF superfamily member 13	Homo sapiens	125-130
21471524-3	2011	Modification of heparan sulfate by glucuronyl C5-epimerase (Glce) controls heparan sulfate-chain flexibility and thereby affects ligand binding.	Heparitin Sulfate	75-90	glucuronic acid epimerase	Homo sapiens	35-58
21471524-3	2011	Modification of heparan sulfate by glucuronyl C5-epimerase (Glce) controls heparan sulfate-chain flexibility and thereby affects ligand binding.	Heparitin Sulfate	75-90	glucuronic acid epimerase	Homo sapiens	60-64
21471211-0	2011	Highly sulfated nonreducing end-derived heparan sulfate domains bind fibroblast growth factor-2 with high affinity and are enriched in biologically active fractions.	Heparitin Sulfate	40-55	fibroblast growth factor 2	Homo sapiens	69-95
21454625-0	2011	The dominating role of N-deacetylase/N-sulfotransferase 1 in forming domain structures in heparan sulfate.	Heparitin Sulfate	90-105	N-deacetylase and N-sulfotransferase 1	Homo sapiens	23-57
21471211-3	2011	Effective binding of FGF2 to its receptor requires the presence of heparan sulfate (HS), a linear polysaccharide with N-sulfated domains (NS) localized at the cell surface and extracellular matrix.	Heparitin Sulfate	67-82	fibroblast growth factor 2	Homo sapiens	21-25
21471211-3	2011	Effective binding of FGF2 to its receptor requires the presence of heparan sulfate (HS), a linear polysaccharide with N-sulfated domains (NS) localized at the cell surface and extracellular matrix.	Heparitin Sulfate	84-86	fibroblast growth factor 2	Homo sapiens	21-25
21443520-2	2011	hHS6ST2 (human heparan sulfate D-glucosaminyl 6-O-sulfotransferase-2) is a Golgi-resident enzyme that usually acts on GlcA/IdoA(2S)-GlcNAc/NS disaccharide-6-sulfate modifications within the HS sequence.	Heparitin Sulfate	15-30	heparan sulfate 6-O-sulfotransferase 2	Homo sapiens	0-7
21482826-3	2011	In this study we demonstrated that the viral protein binds to heparan sulfate side chains of syndecan-2, syndecan-4, and CD44v3 purified from HeLa cells and that these heparan sulfate proteoglycans (HSPGs) co-localize with HIV-1 p17 on activated human CD4(+) T cells by confocal fluorescence analysis.	Heparitin Sulfate	62-77	syndecan 2	Homo sapiens	93-103
21482826-3	2011	In this study we demonstrated that the viral protein binds to heparan sulfate side chains of syndecan-2, syndecan-4, and CD44v3 purified from HeLa cells and that these heparan sulfate proteoglycans (HSPGs) co-localize with HIV-1 p17 on activated human CD4(+) T cells by confocal fluorescence analysis.	Heparitin Sulfate	62-77	syndecan 4	Homo sapiens	105-115
21482826-3	2011	In this study we demonstrated that the viral protein binds to heparan sulfate side chains of syndecan-2, syndecan-4, and CD44v3 purified from HeLa cells and that these heparan sulfate proteoglycans (HSPGs) co-localize with HIV-1 p17 on activated human CD4(+) T cells by confocal fluorescence analysis.	Heparitin Sulfate	62-77	CD4 molecule	Homo sapiens	121-124
21482826-0	2011	HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production.	Heparitin Sulfate	40-55	family with sequence similarity 72 member B	Homo sapiens	6-9
21482826-0	2011	HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production.	Heparitin Sulfate	40-55	CD4 molecule	Homo sapiens	70-73
21482826-0	2011	HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production.	Heparitin Sulfate	40-55	tumor necrosis factor	Homo sapiens	171-198
21482826-0	2011	HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production.	Heparitin Sulfate	40-55	interleukin 2	Homo sapiens	203-216
21308479-5	2011	In addition, cathepsin L is held responsible for processing and activation of heparanase, an endo-beta-glucuronidase capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans, activity that is strongly implicated in cell dissemination associated with tumor metastasis, angiogenesis, and inflammation.	Heparitin Sulfate	137-152	cathepsin L	Homo sapiens	13-24
21308479-5	2011	In addition, cathepsin L is held responsible for processing and activation of heparanase, an endo-beta-glucuronidase capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans, activity that is strongly implicated in cell dissemination associated with tumor metastasis, angiogenesis, and inflammation.	Heparitin Sulfate	137-152	glucuronidase beta	Homo sapiens	98-116
21424539-3	2011	We therefore sought to determine whether: (1) heparan sulphate reduction in endothelial cells is due to increased HPR1 production through increased reactive oxygen species (ROS) production; and (2) HPR1 production is increased in vivo in endothelial cells under hyperglycaemic and/or atherosclerotic conditions.	Heparitin Sulfate	46-62	heparanase	Homo sapiens	114-118
21424539-8	2011	Exogenous H(2)O(2) induced HPR1 production, subsequently leading to decreased cell surface heparan sulphate levels.	Heparitin Sulfate	91-107	heparanase	Homo sapiens	27-31
21469128-2	2011	Because syndecan-4 (SD-4), the coinhibitor for DC-associated heparan sulfate proteoglycan integrin ligand (DC-HIL), lacks such an ITIM, we posited that SD-4 links with a PTP in an ITIM-independent manner.	Heparitin Sulfate	61-76	syndecan 4	Homo sapiens	8-18
24098092-7	2011	Furthermore, robustness can be achieved by substantial binding of the signaling morphogen Dpp with nonsignaling cell surface bound molecules (such as heparan sulfate proteoglygans) and degrading the resulting complexes at a sufficiently rapid rate.	Heparitin Sulfate	150-165	decapentaplegic	Drosophila melanogaster	90-93
21469128-2	2011	Because syndecan-4 (SD-4), the coinhibitor for DC-associated heparan sulfate proteoglycan integrin ligand (DC-HIL), lacks such an ITIM, we posited that SD-4 links with a PTP in an ITIM-independent manner.	Heparitin Sulfate	61-76	syndecan 4	Homo sapiens	20-24
21805439-6	2011	In particular, HCII binds many glycosaminoglycans (GAGs) such as heparin and heparin sulfate as well as several different polyanions to enhance its inhibition of thrombin.	Heparitin Sulfate	77-92	serpin family D member 1	Homo sapiens	15-19
21184148-2	2011	METHODS: Heparan sulfate was isolated and purified from the conditioned media of human bone marrow stromal cells and used for the expansion of cord blood-derived CD34(+) cells in the presence of a cocktail of cytokines.	Heparitin Sulfate	9-24	CD34 molecule	Homo sapiens	162-166
21420339-1	2011	Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder caused by deficiency of the enzyme iduronate-2-sulfatase, responsible for the degradation of glycosaminoglycans dermatan and heparan sulfate.	Heparitin Sulfate	196-211	iduronate 2-sulfatase	Homo sapiens	106-127
21805445-4	2011	Among various functions of HRG, its interactions with heparin/heparan sulfate, fibrinogen, and plasminogen are thought to be intimately related to its roles in the coagulation and fibrinolytic systems.	Heparitin Sulfate	62-77	histidine rich glycoprotein	Homo sapiens	27-30
21454551-4	2011	Our analysis showed that heparan sulfate modification is required for the trans co-receptor activity of DALLY.	Heparitin Sulfate	25-40	division abnormally delayed	Drosophila melanogaster	104-109
21569759-1	2011	The cell surface heparan sulfate proteoglycan, syndecan-2, is crucial for the tumorigenic activity of colon cancer cells.	Heparitin Sulfate	17-32	syndecan 2	Homo sapiens	47-57
21464728-3	2011	The mammalian heparanase is an endo-beta-glucuronidase that can cleave heparan sulfate at specific molecular sites, resulting in structural modification of the extracellular matrix barrier, facilitating cancer cell invasion, and eventual metastasis.	Heparitin Sulfate	71-86	glucuronidase beta	Homo sapiens	36-54
22303316-3	2011	Heparanase (HPSE) and hyaluronidases (HYAL) are responsible for degrading heparan sulfate and hyaluronan, respectively.	Heparitin Sulfate	74-89	heparanase	Sus scrofa	0-10
22303316-3	2011	Heparanase (HPSE) and hyaluronidases (HYAL) are responsible for degrading heparan sulfate and hyaluronan, respectively.	Heparitin Sulfate	74-89	heparanase	Sus scrofa	12-16
21221614-4	2011	The degradation of heparan sulfate resulted in a marked reduction of binding activity of the basement membrane for vascular endothelial growth factor, fibroblast growth factor-2 and -7 at the dermal-epidermal junction.	Heparitin Sulfate	19-34	vascular endothelial growth factor A	Homo sapiens	115-149
21221614-4	2011	The degradation of heparan sulfate resulted in a marked reduction of binding activity of the basement membrane for vascular endothelial growth factor, fibroblast growth factor-2 and -7 at the dermal-epidermal junction.	Heparitin Sulfate	19-34	fibroblast growth factor 2	Homo sapiens	151-184
21343305-4	2011	Heparan sulfate is a linear sulfated polysaccharide that facilitates binding and action of some vascular growth factors such as FGF-2 and VEGF-A.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Mus musculus	128-133
21248757-5	2011	Besides, hearts of 8-week-old rats were stimulated with the endogenous TLR4 ligand heparansulfate (HS); the proinflammatory mRNA pattern was assessed (tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, monocyte chemotactic protein (MCP)-1).	Heparitin Sulfate	83-97	toll-like receptor 4	Rattus norvegicus	71-75
21248757-5	2011	Besides, hearts of 8-week-old rats were stimulated with the endogenous TLR4 ligand heparansulfate (HS); the proinflammatory mRNA pattern was assessed (tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, monocyte chemotactic protein (MCP)-1).	Heparitin Sulfate	99-101	toll-like receptor 4	Rattus norvegicus	71-75
21532885-3	2011	Heparanase is an endoglycosidase that degrades heparan sulfate in the tumor microenvironment, cell surfaces, and vessel wall.	Heparitin Sulfate	47-62	heparanase	Mus musculus	0-10
21343305-4	2011	Heparan sulfate is a linear sulfated polysaccharide that facilitates binding and action of some vascular growth factors such as FGF-2 and VEGF-A.	Heparitin Sulfate	0-15	vascular endothelial growth factor A	Mus musculus	138-144
21343305-6	2011	We demonstrate that VEGF-C binds to heparan sulfate purified from primary lymphatic endothelia, and activation of lymphatic endothelial Erk1/2 in response to VEGF-C is reduced by interference with heparin or pretreatment of cells with heparinase, which destroys heparan sulfate.	Heparitin Sulfate	36-51	vascular endothelial growth factor C	Mus musculus	20-26
21343305-6	2011	We demonstrate that VEGF-C binds to heparan sulfate purified from primary lymphatic endothelia, and activation of lymphatic endothelial Erk1/2 in response to VEGF-C is reduced by interference with heparin or pretreatment of cells with heparinase, which destroys heparan sulfate.	Heparitin Sulfate	262-277	vascular endothelial growth factor C	Mus musculus	20-26
21343305-6	2011	We demonstrate that VEGF-C binds to heparan sulfate purified from primary lymphatic endothelia, and activation of lymphatic endothelial Erk1/2 in response to VEGF-C is reduced by interference with heparin or pretreatment of cells with heparinase, which destroys heparan sulfate.	Heparitin Sulfate	262-277	mitogen-activated protein kinase 3	Mus musculus	136-142
21343305-6	2011	We demonstrate that VEGF-C binds to heparan sulfate purified from primary lymphatic endothelia, and activation of lymphatic endothelial Erk1/2 in response to VEGF-C is reduced by interference with heparin or pretreatment of cells with heparinase, which destroys heparan sulfate.	Heparitin Sulfate	262-277	vascular endothelial growth factor C	Mus musculus	158-164
21343305-8	2011	Silencing lymphatic heparan sulfate chain biosynthesis inhibited VEGF-C-mediated Erk1/2 activation and abrogated VEGFR-3 receptor-dependent binding of VEGF-C to the lymphatic endothelial surface.	Heparitin Sulfate	20-35	vascular endothelial growth factor C	Mus musculus	65-71
21343305-8	2011	Silencing lymphatic heparan sulfate chain biosynthesis inhibited VEGF-C-mediated Erk1/2 activation and abrogated VEGFR-3 receptor-dependent binding of VEGF-C to the lymphatic endothelial surface.	Heparitin Sulfate	20-35	mitogen-activated protein kinase 3	Mus musculus	81-87
21343305-8	2011	Silencing lymphatic heparan sulfate chain biosynthesis inhibited VEGF-C-mediated Erk1/2 activation and abrogated VEGFR-3 receptor-dependent binding of VEGF-C to the lymphatic endothelial surface.	Heparitin Sulfate	20-35	FMS-like tyrosine kinase 4	Mus musculus	113-120
21343305-8	2011	Silencing lymphatic heparan sulfate chain biosynthesis inhibited VEGF-C-mediated Erk1/2 activation and abrogated VEGFR-3 receptor-dependent binding of VEGF-C to the lymphatic endothelial surface.	Heparitin Sulfate	20-35	vascular endothelial growth factor C	Mus musculus	151-157
21343305-9	2011	These findings prompted targeting of lymphatic N-deacetylase/N-sulfotransferase-1 (Ndst1), a major sulfate-modifying heparan sulfate biosynthetic enzyme.	Heparitin Sulfate	117-132	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	47-81
21343305-9	2011	These findings prompted targeting of lymphatic N-deacetylase/N-sulfotransferase-1 (Ndst1), a major sulfate-modifying heparan sulfate biosynthetic enzyme.	Heparitin Sulfate	117-132	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	83-88
21343308-0	2011	Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1.	Heparitin Sulfate	0-15	CD47 molecule	Homo sapiens	59-63
21343308-0	2011	Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1.	Heparitin Sulfate	0-15	thrombospondin 1	Homo sapiens	124-140
21454754-5	2011	Heparan sulfate and analogs induced RPTPsigma ectodomain oligomerization in solution, which was inhibited by chondroitin sulfate.	Heparitin Sulfate	0-15	protein tyrosine phosphatase receptor type S	Homo sapiens	36-45
21366263-7	2011	The increased susceptibility of the differentiated cells is in agreement with more abundant expression of a proteoglycan, syndecan-1, which contains copious heparin sulfate side chains.	Heparitin Sulfate	157-172	syndecan 1	Homo sapiens	122-132
21521498-1	2011	UNLABELLED: Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder caused by a genetic defect in alpha-L-iduronidase (IDUA) which is involved in the degradation of dermatan and heparan sulfates.	Heparitin Sulfate	212-228	alpha-L-iduronidase	Homo sapiens	132-151
21521498-1	2011	UNLABELLED: Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder caused by a genetic defect in alpha-L-iduronidase (IDUA) which is involved in the degradation of dermatan and heparan sulfates.	Heparitin Sulfate	212-228	alpha-L-iduronidase	Homo sapiens	153-157
21357686-0	2011	Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate.	Heparitin Sulfate	94-109	fibroblast growth factor 10	Homo sapiens	31-36
21370880-0	2011	Characterization of annexin A1 glycan binding reveals binding to highly sulfated glycans with preference for highly sulfated heparan sulfate and heparin.	Heparitin Sulfate	125-140	annexin A1	Homo sapiens	20-30
21357686-6	2011	Altering Hs2st caused a much less severe phenotype, but the Hs2st;Hs6st double mutants completely abolished lacrimal gland development, suggesting that both 2-O and 6-O sulfation of heparan sulfate contribute to FGF signaling.	Heparitin Sulfate	182-197	heparan sulfate 6-O-sulfotransferase 1	Homo sapiens	66-71
21357686-7	2011	Combined Hs2st;Hs6st deficiency synergistically disrupted the formation of Fgf10-Fgfr2b-heparan sulfate complex on the cell surface and prevented lacrimal gland induction by Fgf10 in explant cultures.	Heparitin Sulfate	88-103	heparan sulfate 6-O-sulfotransferase 1	Homo sapiens	15-20
21357686-7	2011	Combined Hs2st;Hs6st deficiency synergistically disrupted the formation of Fgf10-Fgfr2b-heparan sulfate complex on the cell surface and prevented lacrimal gland induction by Fgf10 in explant cultures.	Heparitin Sulfate	88-103	fibroblast growth factor 10	Homo sapiens	75-80
21357686-9	2011	Therefore, Fgf10-Fgfr2b signaling during lacrimal gland development is sensitive to the content or arrangement of O-sulfate groups in heparan sulfate.	Heparitin Sulfate	134-149	fibroblast growth factor 10	Homo sapiens	11-16
21370880-5	2011	Using heparin/heparan sulfate microarrays, highly sulfated heparan sulfate/heparin were identified as preferred ligands of annexin A1.	Heparitin Sulfate	14-29	annexin A1	Homo sapiens	123-133
21370880-5	2011	Using heparin/heparan sulfate microarrays, highly sulfated heparan sulfate/heparin were identified as preferred ligands of annexin A1.	Heparitin Sulfate	59-74	annexin A1	Homo sapiens	123-133
21370880-6	2011	Binding of annexin A1 to heparin/heparan sulfate is calcium- but not magnesium-dependent.	Heparitin Sulfate	33-48	annexin A1	Homo sapiens	11-21
21370880-7	2011	An in-depth structure-activity relationship of annexin A1-heparan sulfate interactions was established using chemically defined sugars.	Heparitin Sulfate	58-73	annexin A1	Homo sapiens	47-57
21447157-3	2011	Beside the well-known stabilization of FGF2 by heparin or heparan sulphate, the recently discovered binding to ATP also shows a stabilizing and protective effect on this growth factor.	Heparitin Sulfate	58-74	fibroblast growth factor 2	Homo sapiens	39-43
21447736-3	2011	In this study, we establish the role of heparanase-the only known mammalian endoglycosidase that cleaves heparan sulfate-in modulating the response of pancreatic cancer to radiotherapy.	Heparitin Sulfate	105-120	heparanase	Homo sapiens	40-50
21308866-6	2011	In this study, we demonstrate that specific HS/heparin polysaccharides support formation of Sox1(+) neural progenitor cells from wild-type ES cells.	Heparitin Sulfate	44-47	SRY (sex determining region Y)-box 1	Mus musculus	92-96
21408219-1	2011	BACKGROUND: Sanfilippo syndrome type B (MPS III B) is caused by a deficiency of alpha-N-acetylglucosaminidase enzyme, leading to accumulation of heparan sulfate within lysosomes and eventual progressive cerebral and systemic multiple organ abnormalities.	Heparitin Sulfate	145-160	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	80-109
21329668-1	2011	Natural cytotoxicity receptor 1 (NCR1, NKp46) binds to heparin and heparan sulfate; however, other natural ligands for NKp46 have yet to be elucidated.	Heparitin Sulfate	67-82	natural cytotoxicity triggering receptor 1	Homo sapiens	0-31
21329668-1	2011	Natural cytotoxicity receptor 1 (NCR1, NKp46) binds to heparin and heparan sulfate; however, other natural ligands for NKp46 have yet to be elucidated.	Heparitin Sulfate	67-82	natural cytotoxicity triggering receptor 1	Homo sapiens	33-37
21329668-1	2011	Natural cytotoxicity receptor 1 (NCR1, NKp46) binds to heparin and heparan sulfate; however, other natural ligands for NKp46 have yet to be elucidated.	Heparitin Sulfate	67-82	natural cytotoxicity triggering receptor 1	Homo sapiens	39-44
21329668-3	2011	NKp46-H6 directly bound to plates coated with heparin- and heparan sulfate-conjugated bovine serum albumin with K(d) values of 770 and 850 nM, respectively.	Heparitin Sulfate	59-74	natural cytotoxicity triggering receptor 1	Homo sapiens	0-5
21257720-8	2011	SST0001 also diminishes heparanase-induced shedding of syndecan-1, a heparan sulfate proteoglycan known to be a potent promoter of myeloma growth.	Heparitin Sulfate	69-84	syndecan 1	Homo sapiens	55-65
21257720-9	2011	SST0001 inhibited the heparanase-mediated degradation of syndecan-1 heparan sulfate chains, thus confirming the antiheparanase activity of this compound.	Heparitin Sulfate	68-83	syndecan 1	Homo sapiens	57-67
21252093-0	2011	Sezary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface.	Heparitin Sulfate	62-77	syndecan 4	Homo sapiens	34-44
21252093-5	2011	All of these inhibitory properties were dependent on overexpression of distinct heparan sulfate (HS) moieties by SD-4 on SS cells.	Heparitin Sulfate	80-95	syndecan 4	Homo sapiens	113-117
21252093-5	2011	All of these inhibitory properties were dependent on overexpression of distinct heparan sulfate (HS) moieties by SD-4 on SS cells.	Heparitin Sulfate	97-99	syndecan 4	Homo sapiens	113-117
20129923-0	2011	Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.	Heparitin Sulfate	58-73	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	82-116
21364956-1	2011	Heparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains of heparan sulfate proteoglycans.	Heparitin Sulfate	59-74	heparanase	Homo sapiens	0-10
21193389-8	2011	Examination of chondroitin/dermatan sulfate catabolic enzymes showed that heparan sulfate and heparin can inhibit iduronate 2-sulfatase.	Heparitin Sulfate	74-89	iduronate 2-sulfatase	Homo sapiens	114-135
21185280-3	2011	Ext1 encodes a subunit of the Ext1/Ext2 Golgi-associated protein complex responsible for heparan sulfate (HS) synthesis.	Heparitin Sulfate	89-104	exostosin glycosyltransferase 1	Mus musculus	0-4
21185280-3	2011	Ext1 encodes a subunit of the Ext1/Ext2 Golgi-associated protein complex responsible for heparan sulfate (HS) synthesis.	Heparitin Sulfate	89-104	exostosin glycosyltransferase 1	Mus musculus	30-34
21185280-3	2011	Ext1 encodes a subunit of the Ext1/Ext2 Golgi-associated protein complex responsible for heparan sulfate (HS) synthesis.	Heparitin Sulfate	89-104	exostosin glycosyltransferase 2	Mus musculus	35-39
21185280-3	2011	Ext1 encodes a subunit of the Ext1/Ext2 Golgi-associated protein complex responsible for heparan sulfate (HS) synthesis.	Heparitin Sulfate	106-108	exostosin glycosyltransferase 1	Mus musculus	0-4
21185280-3	2011	Ext1 encodes a subunit of the Ext1/Ext2 Golgi-associated protein complex responsible for heparan sulfate (HS) synthesis.	Heparitin Sulfate	106-108	exostosin glycosyltransferase 1	Mus musculus	30-34
21185280-3	2011	Ext1 encodes a subunit of the Ext1/Ext2 Golgi-associated protein complex responsible for heparan sulfate (HS) synthesis.	Heparitin Sulfate	106-108	exostosin glycosyltransferase 2	Mus musculus	35-39
21339334-8	2011	Interestingly, we found that the heparan sulfate chains of GPC5 display a significantly higher degree of sulfation than those of GPC3.	Heparitin Sulfate	33-48	glypican 5	Homo sapiens	59-63
21339334-8	2011	Interestingly, we found that the heparan sulfate chains of GPC5 display a significantly higher degree of sulfation than those of GPC3.	Heparitin Sulfate	33-48	glypican 3	Homo sapiens	129-133
20129923-1	2011	N-Deacetylase-N-sulfotransferase 1 (Ndst1) catalyzes the initial modification of heparan sulfate and heparin during their biosynthesis by removal of acetyl groups from subsets of N-acetylglucosamine units and subsequent sulfation of the resulting free amino groups.	Heparitin Sulfate	81-96	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	0-34
20129923-1	2011	N-Deacetylase-N-sulfotransferase 1 (Ndst1) catalyzes the initial modification of heparan sulfate and heparin during their biosynthesis by removal of acetyl groups from subsets of N-acetylglucosamine units and subsequent sulfation of the resulting free amino groups.	Heparitin Sulfate	81-96	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	36-41
21347431-0	2011	Glycomics analysis of mammalian heparan sulfates modified by the human extracellular sulfatase HSulf2.	Heparitin Sulfate	32-48	sulfatase 2	Homo sapiens	95-101
21135108-6	2011	The binding site for the GDF-8 prodomain is likely the heparan sulfate chain present on perlecan domain V. These results support and extend the emerging concept that TGFbeta superfamily prodomains target their growth factor dimers to extracellular matrix macromolecules.	Heparitin Sulfate	55-70	myostatin	Homo sapiens	25-30
21135108-6	2011	The binding site for the GDF-8 prodomain is likely the heparan sulfate chain present on perlecan domain V. These results support and extend the emerging concept that TGFbeta superfamily prodomains target their growth factor dimers to extracellular matrix macromolecules.	Heparitin Sulfate	55-70	transforming growth factor beta 1	Homo sapiens	166-173
20855470-1	2011	Glial cell line-derived neurotrophic factor (GDNF) is a heparan sulfate (HS)-binding factor.	Heparitin Sulfate	56-71	glial cell line derived neurotrophic factor	Mus musculus	0-43
21036168-5	2011	We demonstrate by siRNA silencing the crucial importance of the cell surface heparan sulphate proteoglycans syndecan-2 and syndecan-4 in regulating the compensatory effect of TG-FN on osteoblast cell adhesion and actin cytoskeletal formation in the presence of RGD peptides.	Heparitin Sulfate	77-93	syndecan 2	Homo sapiens	108-118
21112773-7	2011	GPC3 is also able to bind basic growth factors such as fibroblast growth factor 2 through its heparan sulphate glycan chains.	Heparitin Sulfate	94-110	glypican 3	Homo sapiens	0-4
21112773-7	2011	GPC3 is also able to bind basic growth factors such as fibroblast growth factor 2 through its heparan sulphate glycan chains.	Heparitin Sulfate	94-110	fibroblast growth factor 2	Homo sapiens	55-81
20855470-1	2011	Glial cell line-derived neurotrophic factor (GDNF) is a heparan sulfate (HS)-binding factor.	Heparitin Sulfate	56-71	glial cell line derived neurotrophic factor	Mus musculus	45-49
20855470-1	2011	Glial cell line-derived neurotrophic factor (GDNF) is a heparan sulfate (HS)-binding factor.	Heparitin Sulfate	73-75	glial cell line derived neurotrophic factor	Mus musculus	0-43
20855470-1	2011	Glial cell line-derived neurotrophic factor (GDNF) is a heparan sulfate (HS)-binding factor.	Heparitin Sulfate	73-75	glial cell line derived neurotrophic factor	Mus musculus	45-49
20956519-2	2011	Membrane NRP-1 is proposed to enhance angiogenesis by promoting the formation of a signaling complex between vascular endothelial growth factor-A(165) (VEGF-A(165)), VEGF receptor-2 (VEGFR-2) and heparan sulfate, whereas the soluble NRP-1 is thought to act as an antagonist of signaling complex formation.	Heparitin Sulfate	196-211	neuropilin 1	Homo sapiens	9-14
21115724-9	2011	Two of these genes, heparan sulfate d-glucosaminyl 3-O-sulfotransferase 3A1 and hyaluronan synthase 2, are also potentially important mediators of wound repair via the production of glycosaminoglycan components.	Heparitin Sulfate	20-35	hyaluronan synthase 2	Canis lupus familiaris	80-101
23908791-1	2011	Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate (HS) side chains at a limited number of sites, activity that is strongly implicated with cell invasion associated with cancer metastasis, a consequence of structural modification that loosens the extracellular matrix barrier.	Heparitin Sulfate	56-71	glucuronidase beta	Homo sapiens	22-42
23908791-1	2011	Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate (HS) side chains at a limited number of sites, activity that is strongly implicated with cell invasion associated with cancer metastasis, a consequence of structural modification that loosens the extracellular matrix barrier.	Heparitin Sulfate	73-75	glucuronidase beta	Homo sapiens	22-42
21200028-4	2011	They interact with syndecan-3, a transmembrane heparan sulfate (HS) proteoglycan, by binding to its HS chains with high affinity.	Heparitin Sulfate	47-62	syndecan 3	Mus musculus	19-29
21200028-4	2011	They interact with syndecan-3, a transmembrane heparan sulfate (HS) proteoglycan, by binding to its HS chains with high affinity.	Heparitin Sulfate	64-66	syndecan 3	Mus musculus	19-29
21200028-4	2011	They interact with syndecan-3, a transmembrane heparan sulfate (HS) proteoglycan, by binding to its HS chains with high affinity.	Heparitin Sulfate	100-102	syndecan 3	Mus musculus	19-29
20974861-2	2011	Genetic evidence indicates that VEGF-stimulated endothelial proliferation in vitro and angiogenesis in vivo depend on heparan sulfate, but a requirement for heparan sulfate in vascular hyperpermeability has not been explored.	Heparitin Sulfate	118-133	vascular endothelial growth factor A	Homo sapiens	32-36
20956519-2	2011	Membrane NRP-1 is proposed to enhance angiogenesis by promoting the formation of a signaling complex between vascular endothelial growth factor-A(165) (VEGF-A(165)), VEGF receptor-2 (VEGFR-2) and heparan sulfate, whereas the soluble NRP-1 is thought to act as an antagonist of signaling complex formation.	Heparitin Sulfate	196-211	vascular endothelial growth factor A	Homo sapiens	109-150
20974861-3	2011	Here we show that altering endothelial cell heparan sulfate biosynthesis in vivo decreases hyperpermeability induced by both VEGF(165) and VEGF(121).	Heparitin Sulfate	44-59	vascular endothelial growth factor A	Homo sapiens	125-129
20974861-3	2011	Here we show that altering endothelial cell heparan sulfate biosynthesis in vivo decreases hyperpermeability induced by both VEGF(165) and VEGF(121).	Heparitin Sulfate	44-59	vascular endothelial growth factor A	Homo sapiens	139-143
22471483-1	2011	OBJECTIVE: Heparanase (HPSE), as the only enzyme which can degrade the extracellular matrix and heparin sulfate in basement membrane, plays an important role in invasion and metastasis of tumor cells.	Heparitin Sulfate	96-111	heparanase	Homo sapiens	11-21
20974861-5	2011	By applying proximity ligation assays to primary brain endothelial cells, we show a direct interaction in situ between heparan sulfate and the VEGF receptor, VEGFR2.	Heparitin Sulfate	119-134	vascular endothelial growth factor A	Homo sapiens	143-147
20974861-5	2011	By applying proximity ligation assays to primary brain endothelial cells, we show a direct interaction in situ between heparan sulfate and the VEGF receptor, VEGFR2.	Heparitin Sulfate	119-134	kinase insert domain receptor	Homo sapiens	158-164
20974861-6	2011	Furthermore, the number of heparan sulfate-VEGFR2 complexes increased in response to both VEGF(165) and VEGF(121).	Heparitin Sulfate	27-42	kinase insert domain receptor	Homo sapiens	43-49
20974861-6	2011	Furthermore, the number of heparan sulfate-VEGFR2 complexes increased in response to both VEGF(165) and VEGF(121).	Heparitin Sulfate	27-42	vascular endothelial growth factor A	Homo sapiens	43-47
20974861-6	2011	Furthermore, the number of heparan sulfate-VEGFR2 complexes increased in response to both VEGF(165) and VEGF(121).	Heparitin Sulfate	27-42	vascular endothelial growth factor A	Homo sapiens	90-94
20974861-7	2011	Genetic or heparin lyase-mediated alteration of endothelial heparan sulfate attenuated phosphorylation of VEGFR2 in response to VEGF(165) and VEGF(121), suggesting that the functional VEGF receptor complex contains heparan sulfate.	Heparitin Sulfate	60-75	kinase insert domain receptor	Homo sapiens	106-112
20974861-7	2011	Genetic or heparin lyase-mediated alteration of endothelial heparan sulfate attenuated phosphorylation of VEGFR2 in response to VEGF(165) and VEGF(121), suggesting that the functional VEGF receptor complex contains heparan sulfate.	Heparitin Sulfate	60-75	vascular endothelial growth factor A	Homo sapiens	106-110
20974861-7	2011	Genetic or heparin lyase-mediated alteration of endothelial heparan sulfate attenuated phosphorylation of VEGFR2 in response to VEGF(165) and VEGF(121), suggesting that the functional VEGF receptor complex contains heparan sulfate.	Heparitin Sulfate	60-75	vascular endothelial growth factor A	Homo sapiens	128-132
20974861-7	2011	Genetic or heparin lyase-mediated alteration of endothelial heparan sulfate attenuated phosphorylation of VEGFR2 in response to VEGF(165) and VEGF(121), suggesting that the functional VEGF receptor complex contains heparan sulfate.	Heparitin Sulfate	60-75	vascular endothelial growth factor A	Homo sapiens	128-132
20974861-7	2011	Genetic or heparin lyase-mediated alteration of endothelial heparan sulfate attenuated phosphorylation of VEGFR2 in response to VEGF(165) and VEGF(121), suggesting that the functional VEGF receptor complex contains heparan sulfate.	Heparitin Sulfate	215-230	kinase insert domain receptor	Homo sapiens	106-112
20974861-7	2011	Genetic or heparin lyase-mediated alteration of endothelial heparan sulfate attenuated phosphorylation of VEGFR2 in response to VEGF(165) and VEGF(121), suggesting that the functional VEGF receptor complex contains heparan sulfate.	Heparitin Sulfate	215-230	vascular endothelial growth factor A	Homo sapiens	106-110
21214932-1	2011	BACKGROUND: SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors.	Heparitin Sulfate	80-95	sulfatase 1	Homo sapiens	12-17
21214932-1	2011	BACKGROUND: SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors.	Heparitin Sulfate	80-95	sulfatase 1	Homo sapiens	19-30
21246051-0	2011	Heparan sulfate proteoglycans mediate interstitial flow mechanotransduction regulating MMP-13 expression and cell motility via FAK-ERK in 3D collagen.	Heparitin Sulfate	0-15	matrix metallopeptidase 13	Rattus norvegicus	87-93
21246051-0	2011	Heparan sulfate proteoglycans mediate interstitial flow mechanotransduction regulating MMP-13 expression and cell motility via FAK-ERK in 3D collagen.	Heparitin Sulfate	0-15	protein tyrosine kinase 2	Rattus norvegicus	127-130
21246051-0	2011	Heparan sulfate proteoglycans mediate interstitial flow mechanotransduction regulating MMP-13 expression and cell motility via FAK-ERK in 3D collagen.	Heparitin Sulfate	0-15	Eph receptor B1	Rattus norvegicus	131-134
21246051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: Cleavage of rat vascular SMC surface glycocalyx heparan sulfate (HS) chains from proteoglycan (PG) core proteins by heparinase or disruption of HS biosynthesis by silencing N-deacetylase/N-sulfotransferase 1 (NDST1) suppressed interstitial flow-induced ERK1/2 activation, interstitial collagenase (MMP-13) expression, and SMC motility in 3D collagen.	Heparitin Sulfate	80-95	N-deacetylase and N-sulfotransferase 1	Rattus norvegicus	205-239
21246051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: Cleavage of rat vascular SMC surface glycocalyx heparan sulfate (HS) chains from proteoglycan (PG) core proteins by heparinase or disruption of HS biosynthesis by silencing N-deacetylase/N-sulfotransferase 1 (NDST1) suppressed interstitial flow-induced ERK1/2 activation, interstitial collagenase (MMP-13) expression, and SMC motility in 3D collagen.	Heparitin Sulfate	80-95	N-deacetylase and N-sulfotransferase 1	Rattus norvegicus	241-246
21246051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: Cleavage of rat vascular SMC surface glycocalyx heparan sulfate (HS) chains from proteoglycan (PG) core proteins by heparinase or disruption of HS biosynthesis by silencing N-deacetylase/N-sulfotransferase 1 (NDST1) suppressed interstitial flow-induced ERK1/2 activation, interstitial collagenase (MMP-13) expression, and SMC motility in 3D collagen.	Heparitin Sulfate	80-95	mitogen activated protein kinase 3	Rattus norvegicus	285-291
21246051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: Cleavage of rat vascular SMC surface glycocalyx heparan sulfate (HS) chains from proteoglycan (PG) core proteins by heparinase or disruption of HS biosynthesis by silencing N-deacetylase/N-sulfotransferase 1 (NDST1) suppressed interstitial flow-induced ERK1/2 activation, interstitial collagenase (MMP-13) expression, and SMC motility in 3D collagen.	Heparitin Sulfate	80-95	matrix metallopeptidase 13	Rattus norvegicus	330-336
21246051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: Cleavage of rat vascular SMC surface glycocalyx heparan sulfate (HS) chains from proteoglycan (PG) core proteins by heparinase or disruption of HS biosynthesis by silencing N-deacetylase/N-sulfotransferase 1 (NDST1) suppressed interstitial flow-induced ERK1/2 activation, interstitial collagenase (MMP-13) expression, and SMC motility in 3D collagen.	Heparitin Sulfate	97-99	N-deacetylase and N-sulfotransferase 1	Rattus norvegicus	205-239
21246051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: Cleavage of rat vascular SMC surface glycocalyx heparan sulfate (HS) chains from proteoglycan (PG) core proteins by heparinase or disruption of HS biosynthesis by silencing N-deacetylase/N-sulfotransferase 1 (NDST1) suppressed interstitial flow-induced ERK1/2 activation, interstitial collagenase (MMP-13) expression, and SMC motility in 3D collagen.	Heparitin Sulfate	97-99	N-deacetylase and N-sulfotransferase 1	Rattus norvegicus	241-246
21246051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: Cleavage of rat vascular SMC surface glycocalyx heparan sulfate (HS) chains from proteoglycan (PG) core proteins by heparinase or disruption of HS biosynthesis by silencing N-deacetylase/N-sulfotransferase 1 (NDST1) suppressed interstitial flow-induced ERK1/2 activation, interstitial collagenase (MMP-13) expression, and SMC motility in 3D collagen.	Heparitin Sulfate	97-99	mitogen activated protein kinase 3	Rattus norvegicus	285-291
21246051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: Cleavage of rat vascular SMC surface glycocalyx heparan sulfate (HS) chains from proteoglycan (PG) core proteins by heparinase or disruption of HS biosynthesis by silencing N-deacetylase/N-sulfotransferase 1 (NDST1) suppressed interstitial flow-induced ERK1/2 activation, interstitial collagenase (MMP-13) expression, and SMC motility in 3D collagen.	Heparitin Sulfate	97-99	matrix metallopeptidase 13	Rattus norvegicus	330-336
20925654-3	2011	This indicates that heparan sulfate on these cells is essential for cell-surface binding of ephrin-B3.	Heparitin Sulfate	20-35	ephrin B3	Homo sapiens	92-101
22471483-1	2011	OBJECTIVE: Heparanase (HPSE), as the only enzyme which can degrade the extracellular matrix and heparin sulfate in basement membrane, plays an important role in invasion and metastasis of tumor cells.	Heparitin Sulfate	96-111	heparanase	Homo sapiens	23-27
21779388-3	2011	These include coagulation factor VIII, platelet glycoprotein 1balpha, and heparin sulfate, which accelerate the cleavage of VWF.	Heparitin Sulfate	74-89	von Willebrand factor	Homo sapiens	124-127
21467632-4	2011	Binding of rGST-NKG2A and rGST-NKG2C to heparin-BSA was suppressed in the presence of soluble heparin, heparan sulfate, fucoidan, lambda-carrageenan, and dextran sulfate.	Heparitin Sulfate	103-118	killer cell lectin like receptor C1	Homo sapiens	16-21
21467632-4	2011	Binding of rGST-NKG2A and rGST-NKG2C to heparin-BSA was suppressed in the presence of soluble heparin, heparan sulfate, fucoidan, lambda-carrageenan, and dextran sulfate.	Heparitin Sulfate	103-118	killer cell lectin like receptor C2	Homo sapiens	31-36
20955806-13	2011	CONCLUSIONS: In conclusion, alternative splicing of SZP is regulated by TGF-beta1 signaling and may regulate SZP interaction with heparin/heparan sulfate or other components in the extracellular matrix of articular cartilage by splicing out of the heparin binding domain.	Heparitin Sulfate	138-153	proteoglycan 4	Homo sapiens	52-55
20955806-13	2011	CONCLUSIONS: In conclusion, alternative splicing of SZP is regulated by TGF-beta1 signaling and may regulate SZP interaction with heparin/heparan sulfate or other components in the extracellular matrix of articular cartilage by splicing out of the heparin binding domain.	Heparitin Sulfate	138-153	transforming growth factor beta 1	Homo sapiens	72-81
20955806-13	2011	CONCLUSIONS: In conclusion, alternative splicing of SZP is regulated by TGF-beta1 signaling and may regulate SZP interaction with heparin/heparan sulfate or other components in the extracellular matrix of articular cartilage by splicing out of the heparin binding domain.	Heparitin Sulfate	138-153	proteoglycan 4	Homo sapiens	109-112
20964630-0	2011	Cell surface heparan sulfates mediate internalization of the PWWP/HATH domain of HDGF via macropinocytosis to fine-tune cell signalling processes involved in fibroblast cell migration.	Heparitin Sulfate	13-29	heparin binding growth factor	Mus musculus	81-85
21212510-1	2011	Lectin-like receptors natural killer group 2D (NKG2D) and CD94 on natural killer (NK) cells bind to alpha2,3-NeuAc-containing N-glycans and heparin/heparan sulfate (HS).	Heparitin Sulfate	148-163	killer cell lectin like receptor K1	Homo sapiens	47-52
21212510-1	2011	Lectin-like receptors natural killer group 2D (NKG2D) and CD94 on natural killer (NK) cells bind to alpha2,3-NeuAc-containing N-glycans and heparin/heparan sulfate (HS).	Heparitin Sulfate	148-163	killer cell lectin like receptor D1	Homo sapiens	58-62
21789398-2	2011	INTRODUCTION: Heparanase is an endo-beta-glucuronidase that specifically acts upon the heparan sulfate chains of proteoglycans.	Heparitin Sulfate	87-102	glucuronidase beta	Homo sapiens	36-54
22039521-4	2011	We previously showed that exogenously added LPL increases HCV binding to hepatoma cells by acting as a bridge between virus-associated lipoproteins and cell surface heparan sulfate, while simultaneously decreasing infection levels.	Heparitin Sulfate	165-180	lipoprotein lipase	Homo sapiens	44-47
22135748-2	2011	The degree of sulfate modification on the covalently attached heparan sulfate (HS) chains is one of the determining factors of growth factor-HSPG interactions.	Heparitin Sulfate	62-77	syndecan 2	Homo sapiens	141-145
21698156-2	2011	M402 is a rationally engineered, non-cytotoxic heparan sulfate (HS) mimetic, designed to inhibit multiple factors implicated in tumor-host cell interactions, including VEGF, FGF2, SDF-1alpha, P-selectin, and heparanase.	Heparitin Sulfate	64-66	vascular endothelial growth factor A	Mus musculus	168-172
21041295-0	2010	Thrombin-dependent MMP-2 activity is regulated by heparan sulfate.	Heparitin Sulfate	50-65	coagulation factor II, thrombin	Homo sapiens	0-8
21041295-0	2010	Thrombin-dependent MMP-2 activity is regulated by heparan sulfate.	Heparitin Sulfate	50-65	matrix metallopeptidase 2	Homo sapiens	19-24
21041295-6	2010	In the present study we demonstrate that heparan sulfate is essential for thrombin-mediated activation of pro-MMP-2.	Heparitin Sulfate	41-56	coagulation factor II, thrombin	Homo sapiens	74-82
21041295-6	2010	In the present study we demonstrate that heparan sulfate is essential for thrombin-mediated activation of pro-MMP-2.	Heparitin Sulfate	41-56	matrix metallopeptidase 2	Homo sapiens	110-115
21041295-7	2010	Binding of heparan sulfate to thrombin is primarily responsible for this activation process, presumably through conformational changes at the active site.	Heparitin Sulfate	11-26	coagulation factor II, thrombin	Homo sapiens	30-38
21041295-8	2010	Furthermore, interaction of MMP-2 with exosites 1 and 2 of thrombin is crucial for thrombin-mediated MMP-2 degradation, and inhibition of this interaction by heparan sulfate or hirudin fragment results in a decrease in MMP-2 degradation.	Heparitin Sulfate	158-173	matrix metallopeptidase 2	Homo sapiens	28-33
21041295-8	2010	Furthermore, interaction of MMP-2 with exosites 1 and 2 of thrombin is crucial for thrombin-mediated MMP-2 degradation, and inhibition of this interaction by heparan sulfate or hirudin fragment results in a decrease in MMP-2 degradation.	Heparitin Sulfate	158-173	coagulation factor II, thrombin	Homo sapiens	59-67
21041295-10	2010	Taken together, our experimental data suggest a novel regulatory mechanism of thrombin-dependent MMP-2 enzymatic activity by heparan sulfate proteoglycans.	Heparitin Sulfate	125-140	coagulation factor II, thrombin	Homo sapiens	78-86
21041295-10	2010	Taken together, our experimental data suggest a novel regulatory mechanism of thrombin-dependent MMP-2 enzymatic activity by heparan sulfate proteoglycans.	Heparitin Sulfate	125-140	matrix metallopeptidase 2	Homo sapiens	97-102
21172016-6	2010	Lymphatic endothelial deficiency in N-deacetylase/N-sulfotransferase-1 (Ndst1), a key enzyme involved in sulfating nascent heparan sulfate chains, resulted in altered lymph node metastasis in tumor-bearing gene targeted mice.	Heparitin Sulfate	123-138	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	36-70
21172016-6	2010	Lymphatic endothelial deficiency in N-deacetylase/N-sulfotransferase-1 (Ndst1), a key enzyme involved in sulfating nascent heparan sulfate chains, resulted in altered lymph node metastasis in tumor-bearing gene targeted mice.	Heparitin Sulfate	123-138	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	72-77
21172016-10	2010	Lymphatic heparan sulfate was also required for binding of CCL21 to its receptor CCR7 on tumor cells as well as the activation of migration signaling pathways in tumor cells exposed to lymphatic conditioned medium.	Heparitin Sulfate	10-25	chemokine (C-C motif) receptor 7	Mus musculus	81-85
20876612-3	2010	MPSII is due to inactivity of the enzyme iduronate-2-sulfatase (IDS), which results in the accumulation of storage material in the lysosomes, such as dermatan and heparan sulfates, with consequent cell degeneration in all tissues including, in the severe phenotype, neurodegeneration in the central nervous system (CNS).	Heparitin Sulfate	163-179	iduronate 2-sulfatase	Mus musculus	41-62
20876612-3	2010	MPSII is due to inactivity of the enzyme iduronate-2-sulfatase (IDS), which results in the accumulation of storage material in the lysosomes, such as dermatan and heparan sulfates, with consequent cell degeneration in all tissues including, in the severe phenotype, neurodegeneration in the central nervous system (CNS).	Heparitin Sulfate	163-179	iduronate 2-sulfatase	Mus musculus	64-67
21062008-4	2010	Using a gel mobility shift assay, we found that HBD2 bound to a range of GAGs including heparin/heparan sulfate (HS), dermatan sulfate (DS), and chondroitin sulfate.	Heparitin Sulfate	96-111	defensin beta 4A	Homo sapiens	48-52
21058638-1	2010	Heparin and heparan sulfate mediated basic fibroblast growth factor (bFGF) signaling plays an important role in skeletal muscle homeostasis by maintaining a balance between proliferation and differentiation of muscle progenitor cells.	Heparitin Sulfate	12-27	fibroblast growth factor 2	Mus musculus	37-67
21058638-1	2010	Heparin and heparan sulfate mediated basic fibroblast growth factor (bFGF) signaling plays an important role in skeletal muscle homeostasis by maintaining a balance between proliferation and differentiation of muscle progenitor cells.	Heparitin Sulfate	12-27	fibroblast growth factor 2	Mus musculus	69-73
20883685-3	2010	Either expression of full-length or truncated GPC1 in vivo causes defects in trigeminal gangliogenesis in a manner that requires heparan sulfate side chains.	Heparitin Sulfate	129-144	glypican 1	Gallus gallus	46-50
21062061-3	2010	Analyses in vitro and in cellulo revealed that RNase A interacts tightly with abundant cell-surface proteoglycans containing glycosaminoglycans, such as heparan sulfate and chondroitin sulfate, as well as with sialic acid-containing glycoproteins.	Heparitin Sulfate	153-168	ribonuclease A family member 1, pancreatic	Homo sapiens	47-54
20388016-6	2010	Our data suggest that TIMP-3 interacts with heparan sulfate and heparan sulfate proteoglycans and to a lesser extent with heparin and chondroitin sulfate.	Heparitin Sulfate	44-59	TIMP metallopeptidase inhibitor 3	Homo sapiens	22-28
20865198-3	2010	Differential scanning fluorimetry was used to measure the thermostabilisation bestowed by modified heparin polysaccharides (proxies for heparan sulfate) on fibroblast growth factor-1 (FGF-1) and fibroblast growth factor-2 (FGF-2), prototypical heparan sulfate-binding proteins, revealing varied abilities and primary sequence-activity redundancy.	Heparitin Sulfate	136-151	fibroblast growth factor 1	Homo sapiens	156-182
20865198-3	2010	Differential scanning fluorimetry was used to measure the thermostabilisation bestowed by modified heparin polysaccharides (proxies for heparan sulfate) on fibroblast growth factor-1 (FGF-1) and fibroblast growth factor-2 (FGF-2), prototypical heparan sulfate-binding proteins, revealing varied abilities and primary sequence-activity redundancy.	Heparitin Sulfate	136-151	fibroblast growth factor 1	Homo sapiens	184-189
20865198-3	2010	Differential scanning fluorimetry was used to measure the thermostabilisation bestowed by modified heparin polysaccharides (proxies for heparan sulfate) on fibroblast growth factor-1 (FGF-1) and fibroblast growth factor-2 (FGF-2), prototypical heparan sulfate-binding proteins, revealing varied abilities and primary sequence-activity redundancy.	Heparitin Sulfate	136-151	fibroblast growth factor 2	Homo sapiens	195-221
20864536-8	2010	Furthermore, the heparan sulfate/heparin population was less sulfated in serglycin-deficient than in wild type mice indicative for the absence of heparin, which supports that heparin production is dependent on the serglycin core protein.	Heparitin Sulfate	17-32	serglycin	Mus musculus	73-82
20864536-8	2010	Furthermore, the heparan sulfate/heparin population was less sulfated in serglycin-deficient than in wild type mice indicative for the absence of heparin, which supports that heparin production is dependent on the serglycin core protein.	Heparitin Sulfate	17-32	serglycin	Mus musculus	214-223
20138023-5	2010	Quantitative uptake studies and mutational analyses demonstrate that attachment of the cationic CPPs is mediated by specific interactions between the heparan sulfate chains of syndecan-4 and the CPPs.	Heparitin Sulfate	150-165	syndecan 4	Homo sapiens	176-186
20947829-5	2010	METHODS AND RESULTS: Here, we provide evidence that microRNA (miR)-218, which is encoded by an intron of the Slit genes, inhibits the expression of Robo1 and Robo2 and multiple components of the heparan sulfate biosynthetic pathway.	Heparitin Sulfate	195-210	roundabout guidance receptor 1	Homo sapiens	148-153
21049473-5	2010	Surprisingly, the arrays identified only one gene whose dysregulation by T2DM would disrupt HSPG structure: the heparan sulfate glucosamine-6-O-endosulfatase-2 (Sulf2).	Heparitin Sulfate	112-127	syndecan 2	Mus musculus	92-96
20803552-3	2010	Heparanase has been widely implicated in cancer and is the dominant mammalian endoglycosidase which degrades heparan sulfate chains of proteoglycans (HSPG) including syndecans (SDCs).	Heparitin Sulfate	109-124	syndecan 2	Homo sapiens	150-154
20947829-5	2010	METHODS AND RESULTS: Here, we provide evidence that microRNA (miR)-218, which is encoded by an intron of the Slit genes, inhibits the expression of Robo1 and Robo2 and multiple components of the heparan sulfate biosynthetic pathway.	Heparitin Sulfate	195-210	roundabout guidance receptor 2	Homo sapiens	158-163
21085708-3	2010	Prior studies suggested that Lpl is immobilized by way of heparan sulfate proteoglycans on the endothelium, but genetically altering endothelial cell heparan sulfate had no effect on Lpl localization or lipolysis.	Heparitin Sulfate	58-73	lipoprotein lipase	Homo sapiens	29-32
20688960-2	2010	Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B.	Heparitin Sulfate	160-175	platelet factor 4	Homo sapiens	129-134
20688960-2	2010	Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B.	Heparitin Sulfate	160-175	platelet factor 4 variant 1	Homo sapiens	139-146
21093315-3	2010	Here, we generated mutant mice deficient in the enzyme Ext1, which is required for heparan sulfate synthesis, in a Tek-dependent and inducible manner.	Heparitin Sulfate	83-98	exostosin glycosyltransferase 1	Mus musculus	55-59
21093315-3	2010	Here, we generated mutant mice deficient in the enzyme Ext1, which is required for heparan sulfate synthesis, in a Tek-dependent and inducible manner.	Heparitin Sulfate	83-98	TEK receptor tyrosine kinase	Mus musculus	115-118
21123810-0	2010	Replacing the enzyme alpha-L-iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I. Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease caused by loss of activity of alpha-l-iduronidase and attendant accumulation of the glycosaminoglycans dermatan sulfate and heparan sulfate.	Heparitin Sulfate	333-348	alpha-L-iduronidase	Canis lupus familiaris	21-40
20978204-3	2010	Heparanase, an enzyme that cleaves the heparan sulfate chains of proteoglycans, is upregulated in a variety of human tumors, including multiple myeloma.	Heparitin Sulfate	39-54	heparanase	Homo sapiens	0-10
20847643-1	2010	Glypican 3 (GPC3), a glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan, is expressed in a majority of hepatocellular carcinoma tissues.	Heparitin Sulfate	59-74	glypican 3	Homo sapiens	0-10
20685328-3	2010	The serpin, antithrombin, together with its cofactors, heparin and heparan sulfate, perform a critical anticoagulant function by preventing the activation of blood clotting proteinases except when needed at the site of a vascular injury.	Heparitin Sulfate	67-82	serpin family C member 1	Homo sapiens	12-24
21047416-8	2010	PlnDI binding to neuropilin-1, but not to VEGF receptor-2 is dependent upon the heparan sulfate chains adorning PlnDI.	Heparitin Sulfate	80-95	neuropilin 1	Homo sapiens	17-29
21047416-11	2010	Moreover, PlnDI heparan sulfate chains alone or together with VEGF165 can enhance VEGFR-2 signaling and angiogenic events, in vitro.	Heparitin Sulfate	16-31	kinase insert domain receptor	Homo sapiens	82-89
20847643-1	2010	Glypican 3 (GPC3), a glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan, is expressed in a majority of hepatocellular carcinoma tissues.	Heparitin Sulfate	59-74	glypican 3	Homo sapiens	12-16
20806113-4	2010	High affinity for heparan sulfates was thought to be central to all of PF4"s biological functions.	Heparitin Sulfate	18-34	platelet factor 4	Homo sapiens	71-74
20876352-5	2010	Although no variant-specific differences in the cofactor activity were detected, when heparan sulfate (HS) was added to these assays, it accelerated the rate of C3b cleavage, and this effect could be modulated by degree of HS sulfation.	Heparitin Sulfate	86-101	complement C3	Homo sapiens	161-164
20876352-5	2010	Although no variant-specific differences in the cofactor activity were detected, when heparan sulfate (HS) was added to these assays, it accelerated the rate of C3b cleavage, and this effect could be modulated by degree of HS sulfation.	Heparitin Sulfate	103-105	complement C3	Homo sapiens	161-164
20872591-2	2010	EXT1 and EXT2 encode glycosyltransferases required for the synthesis of heparan sulfate (HS) chains.	Heparitin Sulfate	72-87	exostosin glycosyltransferase 1	Homo sapiens	0-4
20872591-2	2010	EXT1 and EXT2 encode glycosyltransferases required for the synthesis of heparan sulfate (HS) chains.	Heparitin Sulfate	72-87	exostosin glycosyltransferase 2	Homo sapiens	9-13
20872591-2	2010	EXT1 and EXT2 encode glycosyltransferases required for the synthesis of heparan sulfate (HS) chains.	Heparitin Sulfate	89-91	exostosin glycosyltransferase 1	Homo sapiens	0-4
20872591-2	2010	EXT1 and EXT2 encode glycosyltransferases required for the synthesis of heparan sulfate (HS) chains.	Heparitin Sulfate	89-91	exostosin glycosyltransferase 2	Homo sapiens	9-13
21076620-1	2010	Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies.	Heparitin Sulfate	67-82	heparanase	Homo sapiens	0-12
21076620-1	2010	Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies.	Heparitin Sulfate	67-82	heparanase	Homo sapiens	14-18
21076620-1	2010	Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies.	Heparitin Sulfate	84-86	heparanase	Homo sapiens	0-12
21076620-1	2010	Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies.	Heparitin Sulfate	84-86	heparanase	Homo sapiens	14-18
21076620-4	2010	Flow cytometric analysis revealed that B-Raf activation led to loss of the cell surface HS, which could be blocked by two HPR1 inhibitors: heparin and PI-88.	Heparitin Sulfate	88-90	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	39-44
21076620-4	2010	Flow cytometric analysis revealed that B-Raf activation led to loss of the cell surface HS, which could be blocked by two HPR1 inhibitors: heparin and PI-88.	Heparitin Sulfate	88-90	heparanase	Homo sapiens	122-126
20729553-0	2010	Binding of procollagen C-proteinase enhancer-1 (PCPE-1) to heparin/heparan sulfate: properties and role in PCPE-1 interaction with cells.	Heparitin Sulfate	67-82	procollagen C-endopeptidase enhancer protein	Mus musculus	11-46
20975989-0	2010	Regulation of pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate.	Heparitin Sulfate	103-118	vascular endothelial growth factor A	Mus musculus	72-76
20975989-0	2010	Regulation of pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate.	Heparitin Sulfate	103-118	kinase insert domain protein receptor	Mus musculus	77-83
20975989-9	2010	In vitro assays demonstrated that the ocular fluid or soluble heparan sulfate or heparin inhibited the binding of VEGF-A and immobilized heparin or VEGF receptor 2 but not VEGF receptor 1.	Heparitin Sulfate	62-77	vascular endothelial growth factor A	Mus musculus	114-120
20975989-9	2010	In vitro assays demonstrated that the ocular fluid or soluble heparan sulfate or heparin inhibited the binding of VEGF-A and immobilized heparin or VEGF receptor 2 but not VEGF receptor 1.	Heparitin Sulfate	62-77	kinase insert domain protein receptor	Mus musculus	148-163
20975989-9	2010	In vitro assays demonstrated that the ocular fluid or soluble heparan sulfate or heparin inhibited the binding of VEGF-A and immobilized heparin or VEGF receptor 2 but not VEGF receptor 1.	Heparitin Sulfate	62-77	vascular endothelial growth factor A	Mus musculus	114-118
20729553-0	2010	Binding of procollagen C-proteinase enhancer-1 (PCPE-1) to heparin/heparan sulfate: properties and role in PCPE-1 interaction with cells.	Heparitin Sulfate	67-82	procollagen C-endopeptidase enhancer protein	Mus musculus	48-54
20562530-0	2010	Sweet cues: How heparan sulfate modification of fibronectin enables growth factor guided migration of embryonic cells.	Heparitin Sulfate	16-31	fibronectin 1	Homo sapiens	48-59
20650889-1	2010	Heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase (HGSNAT) catalyzes the transmembrane acetylation of heparan sulfate in lysosomes required for its further catabolism.	Heparitin Sulfate	119-134	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	0-66
20650889-1	2010	Heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase (HGSNAT) catalyzes the transmembrane acetylation of heparan sulfate in lysosomes required for its further catabolism.	Heparitin Sulfate	119-134	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	68-74
20813973-3	2010	Products of the EXT gene are involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	41-56	exostosin glycosyltransferase 1	Homo sapiens	16-19
20813973-3	2010	Products of the EXT gene are involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	58-60	exostosin glycosyltransferase 1	Homo sapiens	16-19
20684947-8	2010	CONCLUSIONS: Such synchronized expression modes among the HS metabolism-related molecules suggested that heparanase plays an important role in degradation of HS chains, which is closely related to vascular penetration into the stellate reticulum, which may be one of the driving forces for the postnatal regression of the enamel organ.	Heparitin Sulfate	58-60	heparanase	Mus musculus	105-115
20684947-8	2010	CONCLUSIONS: Such synchronized expression modes among the HS metabolism-related molecules suggested that heparanase plays an important role in degradation of HS chains, which is closely related to vascular penetration into the stellate reticulum, which may be one of the driving forces for the postnatal regression of the enamel organ.	Heparitin Sulfate	158-160	heparanase	Mus musculus	105-115
20562530-4	2010	Specifically, heparan sulfate has been shown to modulate fibronectin structure to reveal previously masked growth factor binding sites.	Heparitin Sulfate	14-29	fibronectin 1	Homo sapiens	57-68
20524207-3	2010	Previous studies have shown that exogenous heparin"s effects on the biological activity of VEGF-A are many and varied, in part due to the endogenous cell-surface heparan sulfates.	Heparitin Sulfate	162-178	vascular endothelial growth factor A	Homo sapiens	91-97
20673764-1	2010	Mucopolysaccharidosis type IIIA (MPS IIIA) is a neurodegenerative metabolic disorder caused by mutations in the N-sulfoglucosamine sulfohydrolase gene with resultant accumulation of partially degraded heparan sulfate (HS).	Heparitin Sulfate	201-216	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-31
20673764-1	2010	Mucopolysaccharidosis type IIIA (MPS IIIA) is a neurodegenerative metabolic disorder caused by mutations in the N-sulfoglucosamine sulfohydrolase gene with resultant accumulation of partially degraded heparan sulfate (HS).	Heparitin Sulfate	218-220	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-31
20840586-1	2010	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate side chains at a limited number of sites, yielding heparan sulfate fragments of still appreciable size.	Heparitin Sulfate	63-78	glucuronidase beta	Homo sapiens	22-42
20840586-1	2010	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate side chains at a limited number of sites, yielding heparan sulfate fragments of still appreciable size.	Heparitin Sulfate	130-145	glucuronidase beta	Homo sapiens	22-42
20524207-5	2010	We showed that VEGF-induced cellular responses are dependent in part on the presence of the heparan sulfates, and that exogenous heparin significantly augments VEGF"s cellular effects especially when endogenous heparan sulfates are absent.	Heparitin Sulfate	92-108	vascular endothelial growth factor A	Homo sapiens	15-19
20524207-5	2010	We showed that VEGF-induced cellular responses are dependent in part on the presence of the heparan sulfates, and that exogenous heparin significantly augments VEGF"s cellular effects especially when endogenous heparan sulfates are absent.	Heparitin Sulfate	211-227	vascular endothelial growth factor A	Homo sapiens	15-19
20524207-5	2010	We showed that VEGF-induced cellular responses are dependent in part on the presence of the heparan sulfates, and that exogenous heparin significantly augments VEGF"s cellular effects especially when endogenous heparan sulfates are absent.	Heparitin Sulfate	211-227	vascular endothelial growth factor A	Homo sapiens	160-164
20576607-0	2010	Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.	Heparitin Sulfate	28-43	heparanase	Homo sapiens	0-10
20576607-6	2010	Notably, the full-length Hpa2c protein inhibits heparanase enzymatic activity, likely due to its high affinity to heparin and heparan sulfate and its ability to associate physically with heparanase.	Heparitin Sulfate	126-141	heparanase	Homo sapiens	48-58
20823601-2	2010	Heparin/heparan sulfate (HS) is required for FGF2 signaling but heparin mimics either promotes or inhibits FGF2 signaling.	Heparitin Sulfate	8-23	fibroblast growth factor 2	Mus musculus	45-49
20699357-8	2010	Thus, LTBP-1 and/or LLC deposition is dependent on pericellular microfibril assembly and is governed by complex interactions between LTBP-1, heparan sulfate, fibrillin-1 and microfibril-associated molecules.	Heparitin Sulfate	141-156	latent transforming growth factor beta binding protein 1	Homo sapiens	6-12
20471664-1	2010	In our earlier work, we demonstrated that agrin, a multifunctional heparan sulfate proteoglycan, accumulates in hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC).	Heparitin Sulfate	67-82	agrin	Homo sapiens	42-47
20561914-1	2010	Heparanase, an endo-beta-D-glucuronidase, is involved in numerous normal physiological and pathological processes, such as inflammation, wound healing and tumour metastasis/angiogenesis, through its ability to mediate the degradation of heparan sulfate, a key structural component of the extracellular matrix and on the surface of cells.	Heparitin Sulfate	237-252	glucuronidase beta	Homo sapiens	20-40
20808809-5	2010	Enzymatic depletion of endogenous nucleic acids or heparan sulphate (HS) from the PrP(C) substrate was found to specifically prevent PrP(res) formation seeded by mouse derived PrP(Sc).	Heparitin Sulfate	51-67	prion protein	Mus musculus	82-88
20678572-1	2010	Fibroblast growth factor-2 (FGF2) is produced and released by endothelial cells and binds to heparan sulfate proteoglycans in the endothelial basement membrane (BM), an important FGF2 storage reservoir.	Heparitin Sulfate	93-108	fibroblast growth factor 2	Homo sapiens	0-26
20678572-1	2010	Fibroblast growth factor-2 (FGF2) is produced and released by endothelial cells and binds to heparan sulfate proteoglycans in the endothelial basement membrane (BM), an important FGF2 storage reservoir.	Heparitin Sulfate	93-108	fibroblast growth factor 2	Homo sapiens	28-32
20713693-9	2010	These phenomena were associated with SOD3-mediated protection against oxidative fragmentation of ECM, such as heparin sulfate and elastin, thereby attenuating lung inflammatory response.	Heparitin Sulfate	110-125	superoxide dismutase 3, extracellular	Mus musculus	37-41
20808809-5	2010	Enzymatic depletion of endogenous nucleic acids or heparan sulphate (HS) from the PrP(C) substrate was found to specifically prevent PrP(res) formation seeded by mouse derived PrP(Sc).	Heparitin Sulfate	51-67	prion protein	Mus musculus	82-85
20547765-9	2010	Collectively, our findings establish the osteo-inductive potential of a heparin-mediated Wnt3a-phosphoinositide 3-kinase/Akt-RUNX2 signaling network and suggest that heparan sulfate supplementation may selectively reduce the therapeutic doses of peptide factors required to promote bone formation.	Heparitin Sulfate	166-181	Wnt family member 3A	Homo sapiens	89-94
20808809-5	2010	Enzymatic depletion of endogenous nucleic acids or heparan sulphate (HS) from the PrP(C) substrate was found to specifically prevent PrP(res) formation seeded by mouse derived PrP(Sc).	Heparitin Sulfate	51-67	prion protein	Mus musculus	133-136
20547765-9	2010	Collectively, our findings establish the osteo-inductive potential of a heparin-mediated Wnt3a-phosphoinositide 3-kinase/Akt-RUNX2 signaling network and suggest that heparan sulfate supplementation may selectively reduce the therapeutic doses of peptide factors required to promote bone formation.	Heparitin Sulfate	166-181	RUNX family transcription factor 2	Homo sapiens	125-130
20808809-5	2010	Enzymatic depletion of endogenous nucleic acids or heparan sulphate (HS) from the PrP(C) substrate was found to specifically prevent PrP(res) formation seeded by mouse derived PrP(Sc).	Heparitin Sulfate	69-71	prion protein	Mus musculus	82-88
20808809-5	2010	Enzymatic depletion of endogenous nucleic acids or heparan sulphate (HS) from the PrP(C) substrate was found to specifically prevent PrP(res) formation seeded by mouse derived PrP(Sc).	Heparitin Sulfate	69-71	prion protein	Mus musculus	82-85
20808809-5	2010	Enzymatic depletion of endogenous nucleic acids or heparan sulphate (HS) from the PrP(C) substrate was found to specifically prevent PrP(res) formation seeded by mouse derived PrP(Sc).	Heparitin Sulfate	69-71	prion protein	Mus musculus	133-136
20570932-8	2010	OSP-1 shares a significant homology with heparinase II/III family protein, which binds and reacts with heparan sulfate proteoglycans.	Heparitin Sulfate	103-118	claudin 11	Homo sapiens	0-3
20548024-0	2010	Cutting edge: C1q binds deoxyribose and heparan sulfate through neighboring sites of its recognition domain.	Heparitin Sulfate	40-55	complement C1q A chain	Homo sapiens	14-17
20690713-7	2010	The use of biologically derived counterpolyanions heparin sulfate and chondroitin sulfate in the multilayer structures enhanced FGF-2 activity.	Heparitin Sulfate	50-65	fibroblast growth factor 2	Mus musculus	128-133
20472933-9	2010	In a mouse model of podocyte injury, protamine sulfate perfusion of the Cfl1 mutant mouse induced a broadened and flattened foot process morphology that was distinct from that observed following perfusion of control kidneys, and mutant podocytes did not recover normal structure following additional perfusion with heparin sulfate.	Heparitin Sulfate	315-330	cofilin 1, non-muscle	Mus musculus	72-76
20529843-12	2010	These data suggest that pst-1 and pst-2 play different physiological roles in heparan sulfate modification and development.	Heparitin Sulfate	78-93	Adenosine 3'-phospho 5'-phosphosulfate transporter 1	Caenorhabditis elegans	24-29
20529843-12	2010	These data suggest that pst-1 and pst-2 play different physiological roles in heparan sulfate modification and development.	Heparitin Sulfate	78-93	Adenosine 3'-phospho 5'-phosphosulfate transporter 2	Caenorhabditis elegans	34-39
20564613-5	2010	FACS and HPLC analyses revealed that the FUT8KO cells had lower cell surface heparan sulfate (HS) levels than CHO WT.	Heparitin Sulfate	77-92	alpha-(1,6)-fucosyltransferase	Cricetulus griseus	41-45
20564613-5	2010	FACS and HPLC analyses revealed that the FUT8KO cells had lower cell surface heparan sulfate (HS) levels than CHO WT.	Heparitin Sulfate	94-96	alpha-(1,6)-fucosyltransferase	Cricetulus griseus	41-45
20564613-9	2010	First, we evaluated transfection of FUT8KO cells with cationic liposomes, which were observed to be less dependent on HS levels for uptake.	Heparitin Sulfate	118-120	alpha-(1,6)-fucosyltransferase	Cricetulus griseus	36-40
20564613-11	2010	The second approach was to engineer a cell line overexpressing exostosin-1 (EXT1), an enzyme responsible for HS chain elongation, to increase HS content.	Heparitin Sulfate	109-111	exostosin-1	Cricetulus griseus	63-74
20564613-11	2010	The second approach was to engineer a cell line overexpressing exostosin-1 (EXT1), an enzyme responsible for HS chain elongation, to increase HS content.	Heparitin Sulfate	109-111	exostosin-1	Cricetulus griseus	76-80
20564613-11	2010	The second approach was to engineer a cell line overexpressing exostosin-1 (EXT1), an enzyme responsible for HS chain elongation, to increase HS content.	Heparitin Sulfate	142-144	exostosin-1	Cricetulus griseus	63-74
20564613-11	2010	The second approach was to engineer a cell line overexpressing exostosin-1 (EXT1), an enzyme responsible for HS chain elongation, to increase HS content.	Heparitin Sulfate	142-144	exostosin-1	Cricetulus griseus	76-80
20797317-6	2010	DKK1 and HS3ST3B1 were shown to play roles in heparan sulfate biosynthesis and the Wnt signaling pathway, respectively.	Heparitin Sulfate	46-61	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	0-4
20797317-6	2010	DKK1 and HS3ST3B1 were shown to play roles in heparan sulfate biosynthesis and the Wnt signaling pathway, respectively.	Heparitin Sulfate	46-61	heparan sulfate-glucosamine 3-sulfotransferase 3B1	Homo sapiens	9-17
20206635-0	2010	Heparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodeling.	Heparitin Sulfate	0-15	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	16-21
20206635-6	2010	A heparan sulfate modifying enzyme, N-deacetylase N-sulfotransferase1 (Ndst1) was deleted in smooth muscle resulting in decreased N- and 2-O sulfation of the heparan sulfate chains.	Heparitin Sulfate	2-17	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	36-69
20206635-6	2010	A heparan sulfate modifying enzyme, N-deacetylase N-sulfotransferase1 (Ndst1) was deleted in smooth muscle resulting in decreased N- and 2-O sulfation of the heparan sulfate chains.	Heparitin Sulfate	2-17	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	71-76
20206635-6	2010	A heparan sulfate modifying enzyme, N-deacetylase N-sulfotransferase1 (Ndst1) was deleted in smooth muscle resulting in decreased N- and 2-O sulfation of the heparan sulfate chains.	Heparitin Sulfate	158-173	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	36-69
20206635-6	2010	A heparan sulfate modifying enzyme, N-deacetylase N-sulfotransferase1 (Ndst1) was deleted in smooth muscle resulting in decreased N- and 2-O sulfation of the heparan sulfate chains.	Heparitin Sulfate	158-173	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	71-76
20206635-9	2010	Taken together, these data provide new evidence that modification of heparan sulfate fine structure through deletion of Ndst1 is sufficient to decrease VSMC proliferation and alter vascular remodeling.	Heparitin Sulfate	69-84	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	120-125
20439611-6	2010	The heparan sulfate chains of the syndecan-Fc hybrid molecule are absolutely required for HIV-1 neutralization.	Heparitin Sulfate	4-19	syndecan 1	Homo sapiens	34-42
20602915-4	2010	The deletions vary from 582 Kb to 738 Kb in size, but invariably encompass only two genes: SULF1, encoding the heparan sulfate 6-O-endosulfatase 1, and SLCO5A1, encoding the solute carrier organic anion transporter family member 5A1.	Heparitin Sulfate	111-126	sulfatase 1	Homo sapiens	91-96
20507176-0	2010	Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan.	Heparitin Sulfate	0-15	fibroblast growth factor 18	Homo sapiens	39-66
20040767-5	2010	While exploring a lack of association between this polymorphism and EDTA plasma MCP-1 concentrations (P = .82), we determined that both clotting and exogenous heparan sulfate (unfractionated heparin) released substantial amounts of MCP-1 from Darc.	Heparitin Sulfate	159-174	C-C motif chemokine ligand 2	Homo sapiens	232-237
20545624-7	2010	Finally a number of both the BMP/GDFs and their antagonists interact with the heparan sulphate side chains of cell-surface and extracellular-matrix proteoglycans.	Heparitin Sulfate	78-94	bone morphogenetic protein 1	Homo sapiens	29-32
20040767-5	2010	While exploring a lack of association between this polymorphism and EDTA plasma MCP-1 concentrations (P = .82), we determined that both clotting and exogenous heparan sulfate (unfractionated heparin) released substantial amounts of MCP-1 from Darc.	Heparitin Sulfate	159-174	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	243-247
20551063-3	2010	We recently found that the exchange protein directly activated by cyclic AMP (Epac) increases melanoma cell migration via a heparan sulfate-related mechanism.	Heparitin Sulfate	124-139	Rap guanine nucleotide exchange factor 3	Homo sapiens	78-82
20410206-6	2010	Down-regulation of Sulf1 was accompanied by an increase in the most highly sulfated forms of heparan sulfate, and a similar increase was observed in female urogenital sinuses treated with testosterone.	Heparitin Sulfate	93-108	sulfatase 1	Homo sapiens	19-24
20383663-0	2010	Establishment of heparan sulphate deficient primary endothelial cells from EXT-1(flox/flox) mouse lungs and sprouting aortas.	Heparitin Sulfate	17-33	exostosin glycosyltransferase 1	Mus musculus	75-80
20501450-1	2010	AIMS: Glypican 3 (GPC3) is a heparan sulphate proteoglycan that shows elevated levels in the serum of patients with hepatocellular carcinoma (HCC), but not in healthy blood donors or patients with benign liver disease.	Heparitin Sulfate	29-45	glypican 3	Homo sapiens	18-22
20307537-1	2010	CD138 (Syndecan 1) is a heparan sulfate proteoglycan that concentrates heparan sulfate-binding growth factors on the surface of normal and malignant plasma cells (multiple myeloma, MMC).	Heparitin Sulfate	24-39	syndecan 1	Homo sapiens	0-5
20307537-1	2010	CD138 (Syndecan 1) is a heparan sulfate proteoglycan that concentrates heparan sulfate-binding growth factors on the surface of normal and malignant plasma cells (multiple myeloma, MMC).	Heparitin Sulfate	24-39	syndecan 1	Homo sapiens	7-17
20583299-3	2010	HGSNAT is localised to the lysosomal membrane and catalyses a transmembrane acetylation in which the terminal glucosamine residue of heparan sulphate acquires an acetyl group, thus forming N-acetylglucosamine.	Heparitin Sulfate	133-149	heparan-alpha-glucosaminide N-acetyltransferase	Homo sapiens	0-6
20501450-1	2010	AIMS: Glypican 3 (GPC3) is a heparan sulphate proteoglycan that shows elevated levels in the serum of patients with hepatocellular carcinoma (HCC), but not in healthy blood donors or patients with benign liver disease.	Heparitin Sulfate	29-45	glypican 3	Homo sapiens	6-16
20564189-0	2010	Controlled delivery of the heparan sulfate/FGF-2 complex by a polyelectrolyte scaffold promotes maximal hMSC proliferation and differentiation.	Heparitin Sulfate	27-42	fibroblast growth factor 2	Homo sapiens	43-48
20564189-3	2010	The aim of this study was to investigate whether a device containing heparan sulfate (HS), which is a co-factor in growth factor-mediated cell proliferation and differentiation, could potentiate and prolong the delivery of fibroblast growth factor-2 (FGF-2) and thus enhance hMSC stimulation.	Heparitin Sulfate	69-84	fibroblast growth factor 2	Homo sapiens	223-249
20564189-3	2010	The aim of this study was to investigate whether a device containing heparan sulfate (HS), which is a co-factor in growth factor-mediated cell proliferation and differentiation, could potentiate and prolong the delivery of fibroblast growth factor-2 (FGF-2) and thus enhance hMSC stimulation.	Heparitin Sulfate	69-84	fibroblast growth factor 2	Homo sapiens	251-256
20564189-3	2010	The aim of this study was to investigate whether a device containing heparan sulfate (HS), which is a co-factor in growth factor-mediated cell proliferation and differentiation, could potentiate and prolong the delivery of fibroblast growth factor-2 (FGF-2) and thus enhance hMSC stimulation.	Heparitin Sulfate	86-88	fibroblast growth factor 2	Homo sapiens	223-249
20564189-3	2010	The aim of this study was to investigate whether a device containing heparan sulfate (HS), which is a co-factor in growth factor-mediated cell proliferation and differentiation, could potentiate and prolong the delivery of fibroblast growth factor-2 (FGF-2) and thus enhance hMSC stimulation.	Heparitin Sulfate	86-88	fibroblast growth factor 2	Homo sapiens	251-256
20534475-2	2010	Individuals with MHE carry heterozygous loss-of-function mutations in Ext1 or Ext2, genes which together encode an enzyme essential for heparan sulfate synthesis.	Heparitin Sulfate	136-151	exostosin glycosyltransferase 1	Mus musculus	70-74
20416374-1	2010	The heparan sulfate (HS) chains of heparan sulfate proteoglycans (HSPG) are "ubiquitous" components of the cell surface and the extracellular matrix (EC) and play important roles in the physiopathology of developmental and homeostatic processes.	Heparitin Sulfate	4-19	syndecan 2	Homo sapiens	66-70
20416374-1	2010	The heparan sulfate (HS) chains of heparan sulfate proteoglycans (HSPG) are "ubiquitous" components of the cell surface and the extracellular matrix (EC) and play important roles in the physiopathology of developmental and homeostatic processes.	Heparitin Sulfate	21-23	syndecan 2	Homo sapiens	66-70
20652491-1	2010	Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is an X-linked inherited disorder caused by a deficiency of the enzyme iduronate-2-sulfatase (IDS), which results in the lysosomal accumulation of glycosaminoglycans (GAG) such as dermatan and heparan sulfate.	Heparitin Sulfate	249-264	iduronate 2-sulfatase	Homo sapiens	127-148
20652491-1	2010	Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is an X-linked inherited disorder caused by a deficiency of the enzyme iduronate-2-sulfatase (IDS), which results in the lysosomal accumulation of glycosaminoglycans (GAG) such as dermatan and heparan sulfate.	Heparitin Sulfate	249-264	iduronate 2-sulfatase	Homo sapiens	150-153
20576134-1	2010	BACKGROUND: The fibroblast growth factor receptor (FGFR) interprets concentration gradients of FGF ligands and structural changes in the heparan sulfate (HS) co-receptor to generate different cellular responses.	Heparitin Sulfate	137-152	fibroblast growth factor 2	Rattus norvegicus	51-54
20404326-0	2010	Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects.	Heparitin Sulfate	28-43	exostosin glycosyltransferase 1	Mus musculus	64-68
20534475-2	2010	Individuals with MHE carry heterozygous loss-of-function mutations in Ext1 or Ext2, genes which together encode an enzyme essential for heparan sulfate synthesis.	Heparitin Sulfate	136-151	exostosin glycosyltransferase 2	Mus musculus	78-82
20382221-0	2010	LTBP-2 has multiple heparin/heparan sulfate binding sites.	Heparitin Sulfate	28-43	latent transforming growth factor beta binding protein 2	Homo sapiens	0-6
20484822-2	2010	The heparan sulfate proteoglycan syndecan-4 is important in mediating fibroblast-matrix interactions, but its role in pulmonary fibrosis has not been explored.	Heparitin Sulfate	4-19	syndecan 4	Mus musculus	33-43
20382221-11	2010	LTBP-2 also showed strong interaction with the heparan sulfate chains of basement membrane HSPG, perlecan.	Heparitin Sulfate	47-62	latent transforming growth factor beta binding protein 2	Homo sapiens	0-6
20231109-4	2010	This presently untreatable condition is caused by N-sulfoglucosamine sulfohydrolase (SGSH) deficiency and is characterized by heparan sulfate accumulation and progressive neurodegeneration.	Heparitin Sulfate	126-141	N-sulfoglucosamine sulfohydrolase	Homo sapiens	50-83
20382221-11	2010	LTBP-2 also showed strong interaction with the heparan sulfate chains of basement membrane HSPG, perlecan.	Heparitin Sulfate	47-62	syndecan 2	Homo sapiens	91-95
20231109-4	2010	This presently untreatable condition is caused by N-sulfoglucosamine sulfohydrolase (SGSH) deficiency and is characterized by heparan sulfate accumulation and progressive neurodegeneration.	Heparitin Sulfate	126-141	N-sulfoglucosamine sulfohydrolase	Homo sapiens	85-89
20230531-2	2010	Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes, a process that depends on the phosphoinositide phosphatidylinositol 4,5-biphosphate (PI(4,5)P(2)) at the inner leaflet as well as heparan sulfate proteoglycans at the outer leaflet of plasma membranes; however, additional core and regulatory components of the FGF2 export machinery have remained elusive.	Heparitin Sulfate	219-234	fibroblast growth factor 2	Homo sapiens	28-32
20619346-1	2010	Heparanase is an endo-beta-glucuronidase that cleaves heparan sulfate side chains presumably at sites of low sulfation, activity that is strongly implicated with cell invasion associated with cancer metastasis, a consequence of structural modification that loosens the extracellular matrix barrier.	Heparitin Sulfate	54-69	glucuronidase beta	Homo sapiens	22-40
20471289-3	2010	The surface-immobilized form of the chemokine CCL21, the heparan sulfate-anchoring ligand of the CC-chemokine receptor 7 (CCR7), caused random movement of DCs that was confined to the chemokine-presenting surface because it triggered integrin-mediated adhesion.	Heparitin Sulfate	57-72	C-C motif chemokine ligand 21	Homo sapiens	46-51
20471289-3	2010	The surface-immobilized form of the chemokine CCL21, the heparan sulfate-anchoring ligand of the CC-chemokine receptor 7 (CCR7), caused random movement of DCs that was confined to the chemokine-presenting surface because it triggered integrin-mediated adhesion.	Heparitin Sulfate	57-72	C-C motif chemokine receptor 7	Homo sapiens	97-120
20377530-6	2010	Then, to examine the roles of EXTL2 in the biosynthesis of HS in EXT1-deficient cells, we focused on the GlcNAc (N-aetylglucosamine) transferase activity of EXTL2, which is involved in the initiation of HS chains by transferring the first GlcNAc to the linkage region.	Heparitin Sulfate	59-61	exostosin like glycosyltransferase 2	Homo sapiens	30-35
20377530-0	2010	Biosynthesis of heparan sulfate in EXT1-deficient cells.	Heparitin Sulfate	16-31	exostosin glycosyltransferase 1	Homo sapiens	35-39
20377530-6	2010	Then, to examine the roles of EXTL2 in the biosynthesis of HS in EXT1-deficient cells, we focused on the GlcNAc (N-aetylglucosamine) transferase activity of EXTL2, which is involved in the initiation of HS chains by transferring the first GlcNAc to the linkage region.	Heparitin Sulfate	59-61	exostosin glycosyltransferase 1	Homo sapiens	65-69
20377530-1	2010	HS (heparan sulfate) is synthesized by HS co-polymerases encoded by the EXT1 and EXT2 genes (exostosin 1 and 2), which are known as causative genes for hereditary multiple exostoses, a dominantly inherited genetic disorder characterized by multiple cartilaginous tumours.	Heparitin Sulfate	0-2	exostosin glycosyltransferase 1	Homo sapiens	72-76
20471289-3	2010	The surface-immobilized form of the chemokine CCL21, the heparan sulfate-anchoring ligand of the CC-chemokine receptor 7 (CCR7), caused random movement of DCs that was confined to the chemokine-presenting surface because it triggered integrin-mediated adhesion.	Heparitin Sulfate	57-72	C-C motif chemokine receptor 7	Homo sapiens	122-126
20377530-1	2010	HS (heparan sulfate) is synthesized by HS co-polymerases encoded by the EXT1 and EXT2 genes (exostosin 1 and 2), which are known as causative genes for hereditary multiple exostoses, a dominantly inherited genetic disorder characterized by multiple cartilaginous tumours.	Heparitin Sulfate	0-2	exostosin glycosyltransferase 2	Homo sapiens	81-85
20377530-6	2010	Then, to examine the roles of EXTL2 in the biosynthesis of HS in EXT1-deficient cells, we focused on the GlcNAc (N-aetylglucosamine) transferase activity of EXTL2, which is involved in the initiation of HS chains by transferring the first GlcNAc to the linkage region.	Heparitin Sulfate	203-205	exostosin like glycosyltransferase 2	Homo sapiens	157-162
20377530-1	2010	HS (heparan sulfate) is synthesized by HS co-polymerases encoded by the EXT1 and EXT2 genes (exostosin 1 and 2), which are known as causative genes for hereditary multiple exostoses, a dominantly inherited genetic disorder characterized by multiple cartilaginous tumours.	Heparitin Sulfate	0-2	exostosin glycosyltransferase 1	Homo sapiens	93-110
20154082-0	2010	Heparan sulfate chain valency controls syndecan-4 function in cell adhesion.	Heparitin Sulfate	0-15	syndecan 4	Homo sapiens	39-49
20377530-1	2010	HS (heparan sulfate) is synthesized by HS co-polymerases encoded by the EXT1 and EXT2 genes (exostosin 1 and 2), which are known as causative genes for hereditary multiple exostoses, a dominantly inherited genetic disorder characterized by multiple cartilaginous tumours.	Heparitin Sulfate	4-19	exostosin glycosyltransferase 1	Homo sapiens	72-76
20377530-1	2010	HS (heparan sulfate) is synthesized by HS co-polymerases encoded by the EXT1 and EXT2 genes (exostosin 1 and 2), which are known as causative genes for hereditary multiple exostoses, a dominantly inherited genetic disorder characterized by multiple cartilaginous tumours.	Heparitin Sulfate	4-19	exostosin glycosyltransferase 2	Homo sapiens	81-85
20377530-1	2010	HS (heparan sulfate) is synthesized by HS co-polymerases encoded by the EXT1 and EXT2 genes (exostosin 1 and 2), which are known as causative genes for hereditary multiple exostoses, a dominantly inherited genetic disorder characterized by multiple cartilaginous tumours.	Heparitin Sulfate	4-19	exostosin glycosyltransferase 1	Homo sapiens	93-110
20377530-3	2010	In the present paper we show, unexpectedly, that two distinct cell lines defective in EXT1 expression indeed produce small but significant amounts of HS chains.	Heparitin Sulfate	150-152	exostosin glycosyltransferase 1	Homo sapiens	86-90
20377530-4	2010	The HS chains produced without the aid of EXT1 were shorter than HS chains formed in concert with EXT1 and EXT2.	Heparitin Sulfate	4-6	exostosin glycosyltransferase 1	Homo sapiens	42-46
20207734-4	2010	In contrast, we report that the NTR domain within PCPE-1 leads to superstimulation of bone morphogenetic protein-1 activity in the presence of heparin and heparan sulfate.	Heparitin Sulfate	155-170	procollagen C-endopeptidase enhancer	Homo sapiens	50-56
20207734-4	2010	In contrast, we report that the NTR domain within PCPE-1 leads to superstimulation of bone morphogenetic protein-1 activity in the presence of heparin and heparan sulfate.	Heparitin Sulfate	155-170	bone morphogenetic protein 1	Homo sapiens	86-114
20495770-5	2010	The plasma concentrations of heparan sulfate and syndecan-1 strongly correlate with severity of sepsis and with inflammatory markers such as interleukin-6 (IL-6).	Heparitin Sulfate	29-44	interleukin 6	Homo sapiens	141-154
20495770-5	2010	The plasma concentrations of heparan sulfate and syndecan-1 strongly correlate with severity of sepsis and with inflammatory markers such as interleukin-6 (IL-6).	Heparitin Sulfate	29-44	interleukin 6	Homo sapiens	156-160
20377530-8	2010	These findings indicate that the transfer of the first GlcNAc residue to the linkage region by EXTL2 is critically required for the biosynthesis of HS in cells deficient in EXT1.	Heparitin Sulfate	148-150	exostosin like glycosyltransferase 2	Homo sapiens	95-100
20377530-8	2010	These findings indicate that the transfer of the first GlcNAc residue to the linkage region by EXTL2 is critically required for the biosynthesis of HS in cells deficient in EXT1.	Heparitin Sulfate	148-150	exostosin glycosyltransferase 1	Homo sapiens	173-177
20154082-7	2010	Measurements of focal contact/adhesion size and focal adhesion kinase phosphorylation correlated with syndecan-4 status and alpha-smooth muscle actin organization, being reduced where syndecan-4 function was compromised by a lack of multiple heparan sulfate chains.	Heparitin Sulfate	242-257	syndecan 4	Homo sapiens	184-194
20176392-1	2010	Human antibodies specific for glycoprotein C (gC1) of herpes simplex virus type 1 (HSV-1) neutralized the virus infectivity and efficiently inhibited attachment of HSV-1 to human HaCaT keratinocytes and to murine mutant L cells expressing either heparan sulfate or chondroitin sulfate at the cell surface.	Heparitin Sulfate	246-261	solute carrier family 25 member 22	Homo sapiens	46-49
20164174-3	2010	GlcAT-I is an enzyme required for the synthesis of both chondroitin sulfate and heparan sulfate.	Heparitin Sulfate	80-95	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)	Mus musculus	0-7
20463901-5	2010	Inflammatory cell invasion and neointimal hyperplasia were significantly reduced in N-deacetylase-N-sulfotransferase-1 (Ndst1(f/f)TekCre(+)) heparan sulfate (GAG)-deficient (Ndst1(-/-), p&lt;0.044) and CCR2-deficient (Ccr2(-/-), p&lt;0.04) donor transplants.	Heparitin Sulfate	141-156	N-deacetylase and N-sulfotransferase 1	Homo sapiens	84-118
20463901-5	2010	Inflammatory cell invasion and neointimal hyperplasia were significantly reduced in N-deacetylase-N-sulfotransferase-1 (Ndst1(f/f)TekCre(+)) heparan sulfate (GAG)-deficient (Ndst1(-/-), p&lt;0.044) and CCR2-deficient (Ccr2(-/-), p&lt;0.04) donor transplants.	Heparitin Sulfate	141-156	C-C motif chemokine receptor 2	Homo sapiens	218-222
20232353-2	2010	MPS IIID is caused by a deficiency of N-acetylglucosamine-6-sulphate sulphatase (GNS), one of the enzymes required for the degradation of heparan sulphate.	Heparitin Sulfate	138-154	glucosamine (N-acetyl)-6-sulfatase	Homo sapiens	81-84
20400703-7	2010	Additionally, we found that CXCL10 was induced in neurons following DENV infection and that CXCL10 competed with DENV for binding to cell surface heparan sulfate, a coreceptor for DENV entry, thus inhibiting binding of DENV to neuronal cells.	Heparitin Sulfate	146-161	chemokine (C-X-C motif) ligand 10	Mus musculus	92-98
20370351-1	2010	BACKGROUND AIMS: Mucopolysaccharidosis type IIIA (MPS IIIA) is a lysosomal storage disorder (LSD) in which an absence of sulfamidase results in incomplete degradation and subsequent accumulation of its substrate, heparan sulfate.	Heparitin Sulfate	213-228	N-sulfoglucosamine sulfohydrolase	Homo sapiens	17-48
20164174-4	2010	Here we report that mice with a deletion of GlcAT-I showed remarkable reduction of the synthesis of chondroitin sulfate and heparan sulfate and embryonic lethality before the 8-cell stage because of failed cytokinesis.	Heparitin Sulfate	124-139	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)	Mus musculus	44-51
20036233-3	2010	Further analysis revealed that in addition to the alpha2beta1 integrin, a second collagen receptor was identified as Syndecan-1 (Sdc1), a cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	151-166	syndecan 1	Homo sapiens	117-127
19968966-10	2010	Inhibition by acetaminophen was maintained in the presence of heparan sulfate and extracellular matrix, materials implicated in the sequestration of MPO at sites of inflammation in vivo.	Heparitin Sulfate	62-77	myeloperoxidase	Homo sapiens	149-152
20419162-1	2010	BACKGROUND: Heparanase, endoglycosidase that cleaves heparan sulfate side chains of heparan sulfate proteoglycans, plays important roles in cancer metastasis, angiogenesis and inflammation.	Heparitin Sulfate	53-68	heparanase	Mus musculus	12-22
20036233-3	2010	Further analysis revealed that in addition to the alpha2beta1 integrin, a second collagen receptor was identified as Syndecan-1 (Sdc1), a cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	151-166	syndecan 1	Homo sapiens	129-133
20208005-0	2010	Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase.	Heparitin Sulfate	56-71	glucuronyl C5-epimerase	Mus musculus	89-112
20208005-6	2010	In this study, we report that modification of HS by the HS-modifying enzyme glucuronyl C5-epimerase (Glce), which controls HS chain flexibility, is required for proper lymphoid organ development.	Heparitin Sulfate	46-48	glucuronyl C5-epimerase	Mus musculus	76-99
20176742-0	2010	Depleting syndecan-4+ T lymphocytes using toxin-bearing dendritic cell-associated heparan sulfate proteoglycan-dependent integrin ligand: a new opportunity for treating activated T cell-driven disease.	Heparitin Sulfate	82-97	syndecan 4	Homo sapiens	10-20
20208005-6	2010	In this study, we report that modification of HS by the HS-modifying enzyme glucuronyl C5-epimerase (Glce), which controls HS chain flexibility, is required for proper lymphoid organ development.	Heparitin Sulfate	46-48	glucuronyl C5-epimerase	Mus musculus	101-105
20208005-6	2010	In this study, we report that modification of HS by the HS-modifying enzyme glucuronyl C5-epimerase (Glce), which controls HS chain flexibility, is required for proper lymphoid organ development.	Heparitin Sulfate	56-58	glucuronyl C5-epimerase	Mus musculus	76-99
20208005-6	2010	In this study, we report that modification of HS by the HS-modifying enzyme glucuronyl C5-epimerase (Glce), which controls HS chain flexibility, is required for proper lymphoid organ development.	Heparitin Sulfate	56-58	glucuronyl C5-epimerase	Mus musculus	101-105
20146670-7	2010	Acceleration of differentiation is mediated by earlier activation of the signalling pathways from heparan sulfate in the extracellular matrix to both FAK (focal adhesion kinase) and MAPK (mitogen-activated protein kinase).	Heparitin Sulfate	98-113	PTK2 protein tyrosine kinase 2	Mus musculus	150-153
20036698-9	2010	We conclude that sulfate moieties within GAGs, like heparin and HS, have an important role in Abeta aggregation in CAA and in Abeta-mediated toxicity of cerebrovascular cells.	Heparitin Sulfate	64-66	amyloid beta precursor protein	Homo sapiens	94-99
20036698-9	2010	We conclude that sulfate moieties within GAGs, like heparin and HS, have an important role in Abeta aggregation in CAA and in Abeta-mediated toxicity of cerebrovascular cells.	Heparitin Sulfate	64-66	amyloid beta precursor protein	Homo sapiens	126-131
20434010-1	2010	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HSPG) on cell surfaces and the extracellular matrix, activity that is strongly implicated in tumor metastasis and angiogenesis.	Heparitin Sulfate	63-78	glucuronidase beta	Homo sapiens	22-42
20434010-1	2010	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HSPG) on cell surfaces and the extracellular matrix, activity that is strongly implicated in tumor metastasis and angiogenesis.	Heparitin Sulfate	80-82	glucuronidase beta	Homo sapiens	22-42
20226534-1	2010	Heparanase is a heparan sulfate (HS) degrading endoglucuronidase that has been implicated in cell migration and inflammatory conditions.	Heparitin Sulfate	16-31	heparanase	Mus musculus	0-10
20226534-1	2010	Heparanase is a heparan sulfate (HS) degrading endoglucuronidase that has been implicated in cell migration and inflammatory conditions.	Heparitin Sulfate	33-35	heparanase	Mus musculus	0-10
20226534-7	2010	Biosynthetic radio-labeling of the macrophages revealed accumulation of non-degraded HS chains in Hpse(-/-) macrophages.	Heparitin Sulfate	85-87	heparanase	Mus musculus	98-102
20146670-7	2010	Acceleration of differentiation is mediated by earlier activation of the signalling pathways from heparan sulfate in the extracellular matrix to both FAK (focal adhesion kinase) and MAPK (mitogen-activated protein kinase).	Heparitin Sulfate	98-113	PTK2 protein tyrosine kinase 2	Mus musculus	155-176
20097750-5	2010	We provide evidence that our lead mutant MCP-1(Y13A/S21K/Q23R) exhibits a 4-fold higher affinity toward the natural MCP-1 GAG ligand heparan sulfate and that it shows a complete deficiency in activating CCR2 on THP-1 cells.	Heparitin Sulfate	133-148	C-C motif chemokine ligand 2	Homo sapiens	41-46
20097750-5	2010	We provide evidence that our lead mutant MCP-1(Y13A/S21K/Q23R) exhibits a 4-fold higher affinity toward the natural MCP-1 GAG ligand heparan sulfate and that it shows a complete deficiency in activating CCR2 on THP-1 cells.	Heparitin Sulfate	133-148	C-C motif chemokine ligand 2	Homo sapiens	116-121
19895887-0	2010	Transient tropoelastin nanoparticles are early-stage intermediates in the coacervation of human tropoelastin whose aggregation is facilitated by heparan sulfate and heparin decasaccharides.	Heparitin Sulfate	145-160	elastin	Homo sapiens	10-22
20097882-5	2010	We discovered that the heparan sulfate chains of syndecan-1 captured VEGF and also attached the syndecan-1/VEGF complex to the extracellular matrix where it then stimulated endothelial invasion.	Heparitin Sulfate	23-38	syndecan 1	Homo sapiens	49-59
20097882-5	2010	We discovered that the heparan sulfate chains of syndecan-1 captured VEGF and also attached the syndecan-1/VEGF complex to the extracellular matrix where it then stimulated endothelial invasion.	Heparitin Sulfate	23-38	vascular endothelial growth factor A	Homo sapiens	69-73
20097882-5	2010	We discovered that the heparan sulfate chains of syndecan-1 captured VEGF and also attached the syndecan-1/VEGF complex to the extracellular matrix where it then stimulated endothelial invasion.	Heparitin Sulfate	23-38	syndecan 1	Homo sapiens	96-106
20097882-5	2010	We discovered that the heparan sulfate chains of syndecan-1 captured VEGF and also attached the syndecan-1/VEGF complex to the extracellular matrix where it then stimulated endothelial invasion.	Heparitin Sulfate	23-38	vascular endothelial growth factor A	Homo sapiens	107-111
20097882-6	2010	In addition to its heparan sulfate chains, the core protein of syndecan-1 was also required because endothelial invasion was blocked by addition of synstatin, a peptide mimic of the integrin activating region present on the syndecan-1 core protein.	Heparitin Sulfate	19-34	syndecan 1	Homo sapiens	63-73
20487506-10	2010	Carriers of the rs8069770 variant allele were associated with a lower risk of HIV MTCT (odds ratio = 0.27, 95% confidence interval = 0.14, 0.51), where rs8069770 is located within HS3ST3A1, a gene involved in heparan sulfate biosynthesis.	Heparitin Sulfate	209-224	heparan sulfate-glucosamine 3-sulfotransferase 3A1	Homo sapiens	180-188
19895887-0	2010	Transient tropoelastin nanoparticles are early-stage intermediates in the coacervation of human tropoelastin whose aggregation is facilitated by heparan sulfate and heparin decasaccharides.	Heparitin Sulfate	145-160	elastin	Homo sapiens	96-108
20169157-6	2010	An incremental increase in CCR5 expression was observed for incremental increases in expression of two heparan sulfate genes involved in viral infection, HS3ST3A1 (beta = 0.27, 95% CI = 0.18, 0.35) and HS3ST3B1 (beta = 0.11, 95% CI = 0.06, 0.18).	Heparitin Sulfate	103-118	C-C motif chemokine receptor 5	Homo sapiens	27-31
20387539-6	2010	Subsequently, we disrupted the gene for Ext 1, an essential enzyme for glycosaminoglycan synthesis of all the heparan sulfate proteoglycans.	Heparitin Sulfate	110-125	exostosin glycosyltransferase 1	Homo sapiens	40-45
20387539-9	2010	Generation of Slit2 and Ext 1 compound mutants caused disturbed activity of Slit proteins, heparin/heparan sulfate-binding chemorepulsive guidance factors.	Heparitin Sulfate	99-114	slit guidance ligand 2	Homo sapiens	14-19
20387539-9	2010	Generation of Slit2 and Ext 1 compound mutants caused disturbed activity of Slit proteins, heparin/heparan sulfate-binding chemorepulsive guidance factors.	Heparitin Sulfate	99-114	exostosin glycosyltransferase 1	Homo sapiens	24-29
20387539-14	2010	Loss of heparan sulfate in neural crest cells disturbed TGFbeta2 signaling such as impaired TGFbeta2-dependent cell proliferation and reduced activity of TGFbeta2-downstream molecules.	Heparitin Sulfate	8-23	transforming growth factor beta 2	Homo sapiens	56-64
20387539-14	2010	Loss of heparan sulfate in neural crest cells disturbed TGFbeta2 signaling such as impaired TGFbeta2-dependent cell proliferation and reduced activity of TGFbeta2-downstream molecules.	Heparitin Sulfate	8-23	transforming growth factor beta 2	Homo sapiens	92-100
20387539-14	2010	Loss of heparan sulfate in neural crest cells disturbed TGFbeta2 signaling such as impaired TGFbeta2-dependent cell proliferation and reduced activity of TGFbeta2-downstream molecules.	Heparitin Sulfate	8-23	transforming growth factor beta 2	Homo sapiens	92-100
20169157-6	2010	An incremental increase in CCR5 expression was observed for incremental increases in expression of two heparan sulfate genes involved in viral infection, HS3ST3A1 (beta = 0.27, 95% CI = 0.18, 0.35) and HS3ST3B1 (beta = 0.11, 95% CI = 0.06, 0.18).	Heparitin Sulfate	103-118	heparan sulfate-glucosamine 3-sulfotransferase 3A1	Homo sapiens	154-162
20169157-6	2010	An incremental increase in CCR5 expression was observed for incremental increases in expression of two heparan sulfate genes involved in viral infection, HS3ST3A1 (beta = 0.27, 95% CI = 0.18, 0.35) and HS3ST3B1 (beta = 0.11, 95% CI = 0.06, 0.18).	Heparitin Sulfate	103-118	heparan sulfate-glucosamine 3-sulfotransferase 3B1	Homo sapiens	202-210
19965677-0	2010	Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma.	Heparitin Sulfate	42-57	exostosin glycosyltransferase 1	Homo sapiens	10-14
19636575-0	2010	Sulfation of heparan sulfate associated with amyloid-beta plaques in patients with Alzheimer"s disease.	Heparitin Sulfate	13-28	amyloid beta precursor protein	Homo sapiens	45-57
19636575-2	2010	Both these lesions consist mainly of aggregated Abeta protein and this aggregation is affected by macromolecules such as heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	121-136	amyloid beta precursor protein	Homo sapiens	48-53
19636575-2	2010	Both these lesions consist mainly of aggregated Abeta protein and this aggregation is affected by macromolecules such as heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	138-140	amyloid beta precursor protein	Homo sapiens	48-53
19636575-8	2010	Thus, our results suggest that a larger variety of HS epitopes is associated with fibrillar Abeta plaques, but the HS epitopes associated with non-fibrillar Abeta plaques seem to be more restricted, selectively consisting of highly N-sulfated epitopes.	Heparitin Sulfate	51-53	amyloid beta precursor protein	Homo sapiens	92-97
19636575-8	2010	Thus, our results suggest that a larger variety of HS epitopes is associated with fibrillar Abeta plaques, but the HS epitopes associated with non-fibrillar Abeta plaques seem to be more restricted, selectively consisting of highly N-sulfated epitopes.	Heparitin Sulfate	115-117	amyloid beta precursor protein	Homo sapiens	157-162
19942287-2	2010	In vivo, fibroblast growth factor 2 (FGF-2) binds to the sulfated glycosaminoglycan heparan sulfate, which is a major component of the ECM.	Heparitin Sulfate	84-99	fibroblast growth factor 2	Homo sapiens	9-35
19942287-2	2010	In vivo, fibroblast growth factor 2 (FGF-2) binds to the sulfated glycosaminoglycan heparan sulfate, which is a major component of the ECM.	Heparitin Sulfate	84-99	fibroblast growth factor 2	Homo sapiens	37-42
19690583-0	2010	Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses.	Heparitin Sulfate	73-89	exostosin-like glycosyltransferase 2	Mus musculus	18-23
19690583-0	2010	Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses.	Heparitin Sulfate	73-89	exostosin-like glycosyltransferase 3	Mus musculus	28-33
20026745-3	2010	The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF.	Heparitin Sulfate	173-188	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
20026745-3	2010	The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF.	Heparitin Sulfate	173-188	interleukin 18	Homo sapiens	48-53
20164500-8	2010	It was also noted that nucleolar HPSE modulates DNA topoisomerase I (Topo I), an enzyme that is highly present in nucleoli, essential for DNA replication and transcription in a variety of tumors, and inhibited by heparan sulfate.	Heparitin Sulfate	213-228	heparanase	Homo sapiens	33-37
20067761-5	2010	This effect was exacerbated by the toll-like receptor-4 ligands heparan sulfate, hyaluronic acid and lipopolysaccharide, and was associated with an increase of hypoxia inducible factor-1alpha expression, the main transcriptional inducer of VEGF in hypoxic conditions.	Heparitin Sulfate	64-79	toll like receptor 4	Homo sapiens	35-55
19822709-0	2010	Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88.	Heparitin Sulfate	68-83	sulfatase 2	Homo sapiens	32-39
19822709-3	2010	We have previously cloned and characterized two human extracellular endoglucosamine 6-sulfatases, HSulf-1 and HSulf-2, which selectively liberate the 6-O sulfate groups on glucosamines present in N, 6-O, and 2-O trisulfated disaccharides of intact HS and heparins.	Heparitin Sulfate	98-100	sulfatase 2	Homo sapiens	110-117
19940140-0	2010	Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases.	Heparitin Sulfate	13-28	peptidylprolyl isomerase B	Homo sapiens	34-47
19940140-1	2010	Cyclophilin B (CyPB) induces migration and adhesion of T lymphocytes via a mechanism that requires interaction with 3-O-sulfated heparan sulfate (HS).	Heparitin Sulfate	129-144	peptidylprolyl isomerase B	Homo sapiens	0-13
19940140-1	2010	Cyclophilin B (CyPB) induces migration and adhesion of T lymphocytes via a mechanism that requires interaction with 3-O-sulfated heparan sulfate (HS).	Heparitin Sulfate	129-144	peptidylprolyl isomerase B	Homo sapiens	15-19
19940140-1	2010	Cyclophilin B (CyPB) induces migration and adhesion of T lymphocytes via a mechanism that requires interaction with 3-O-sulfated heparan sulfate (HS).	Heparitin Sulfate	146-148	peptidylprolyl isomerase B	Homo sapiens	0-13
19940140-1	2010	Cyclophilin B (CyPB) induces migration and adhesion of T lymphocytes via a mechanism that requires interaction with 3-O-sulfated heparan sulfate (HS).	Heparitin Sulfate	146-148	peptidylprolyl isomerase B	Homo sapiens	15-19
20687487-3	2010	This chapter examines how glycoconjugates such as heparan sulfates (HS) and glycosphingolipids, located respectively in the extracellular matrix and lipid bilayers of the cell membranes, facilitate CTX pore formation.	Heparitin Sulfate	50-66	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	198-201
20687487-3	2010	This chapter examines how glycoconjugates such as heparan sulfates (HS) and glycosphingolipids, located respectively in the extracellular matrix and lipid bilayers of the cell membranes, facilitate CTX pore formation.	Heparitin Sulfate	68-70	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	198-201
20008145-7	2010	Treatment from days 7 through 14 with enoxaparin, a functional analogue of the Sdc1 heparan sulfate chains, significantly reduced lethality of KO mice due to DSS-induced colitis, which was correlated with improved mucosal healing.	Heparitin Sulfate	84-99	syndecan 1	Mus musculus	79-83
21694935-3	2010	Moreover, angiotensin II inhibits heparan sulfate synthesis, while heparins modulate angiotensin II signaling in glomerular cells, inhibiting aldosterone synthesis and lowering proteinuria in diabetes patients.	Heparitin Sulfate	34-49	angiotensinogen	Homo sapiens	10-24
19732739-3	2010	In the current study, 2-aminoacridone (2-AMAC)-labeled HS precursor oligosaccharides of various sizes were prepared to investigate the mechanism of heparitinase I-mediated depolymerization using sensitive and quantitative methodologies.	Heparitin Sulfate	55-57	solute carrier family 35 member G5	Homo sapiens	41-45
19732739-4	2010	Furthermore, fluorescent (2-AMAC) tagging of HS precursor oligosaccharides allowed us to distinguish fragments that result from cleavage of the substrates at various time intervals and sites farther away from the reducing and nonreducing ends of oligosaccharide substrates.	Heparitin Sulfate	45-47	solute carrier family 35 member G5	Homo sapiens	28-32
19900405-1	2010	Heparan sulfate 6-O-endosufatases Sulf1 and Sulf2 hydrolyze the 6-O-sulfate of the glucosamine residues in heparin and heparan sulfate, thereby regulating multiple signaling pathways.	Heparitin Sulfate	119-134	sulfatase 1	Rattus norvegicus	34-39
19889634-5	2010	Inactivation of Ndst1 led to decreased overall sulfation of heparan sulfate due to coupling of uronyl 2-O-sulfation and glucosaminyl 6-O-sulfation to initial N-deacetylation and N-sulfation of GlcNAc residues.	Heparitin Sulfate	60-75	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	16-21
19788922-4	2010	It is shown here that perlecan binds myeloperoxidase via its heparan sulfate side chains and that this enhances oxidative damage by myeloperoxidase-derived HOCl and HOBr.	Heparitin Sulfate	61-76	myeloperoxidase	Homo sapiens	37-52
19788922-7	2010	In contrast, the heparan sulfate chains of HOCl/HOBr-modified perlecan retained their ability to bind FGF-2 and collagen V and were able to promote FGF-2-dependent cellular proliferation.	Heparitin Sulfate	17-32	fibroblast growth factor 2	Homo sapiens	102-107
19788922-7	2010	In contrast, the heparan sulfate chains of HOCl/HOBr-modified perlecan retained their ability to bind FGF-2 and collagen V and were able to promote FGF-2-dependent cellular proliferation.	Heparitin Sulfate	17-32	fibroblast growth factor 2	Homo sapiens	148-153
20807644-0	2010	Roles of heparan sulfate in mammalian brain development current views based on the findings from Ext1 conditional knockout studies.	Heparitin Sulfate	9-24	exostosin glycosyltransferase 1	Homo sapiens	97-101
20816204-1	2010	Sulf-1 and Sulf-2 are extracellular endoglucosamine 6-sulfatases, which selectively liberate the 6-O-sulfate groups on glucosamines present in N, 6-O, and 2-O trisulfated disaccharides of intact heparan sulfate (HS)/heparin chains.	Heparitin Sulfate	195-210	sulfatase 1	Homo sapiens	0-6
20816204-1	2010	Sulf-1 and Sulf-2 are extracellular endoglucosamine 6-sulfatases, which selectively liberate the 6-O-sulfate groups on glucosamines present in N, 6-O, and 2-O trisulfated disaccharides of intact heparan sulfate (HS)/heparin chains.	Heparitin Sulfate	195-210	sulfatase 2	Homo sapiens	11-17
20816204-1	2010	Sulf-1 and Sulf-2 are extracellular endoglucosamine 6-sulfatases, which selectively liberate the 6-O-sulfate groups on glucosamines present in N, 6-O, and 2-O trisulfated disaccharides of intact heparan sulfate (HS)/heparin chains.	Heparitin Sulfate	212-214	sulfatase 1	Homo sapiens	0-6
20816204-1	2010	Sulf-1 and Sulf-2 are extracellular endoglucosamine 6-sulfatases, which selectively liberate the 6-O-sulfate groups on glucosamines present in N, 6-O, and 2-O trisulfated disaccharides of intact heparan sulfate (HS)/heparin chains.	Heparitin Sulfate	212-214	sulfatase 2	Homo sapiens	11-17
19751987-3	2010	alpha-l-iduronidase (encoded by the IDUA gene) is a lysosomal enzyme that participates in the degradation of dermatan sulfate and heparan sulfate.	Heparitin Sulfate	130-145	iduronidase, alpha-L	Mus musculus	0-19
19751987-3	2010	alpha-l-iduronidase (encoded by the IDUA gene) is a lysosomal enzyme that participates in the degradation of dermatan sulfate and heparan sulfate.	Heparitin Sulfate	130-145	iduronidase, alpha-L	Mus musculus	36-40
20807641-0	2010	Glucuronyl C5-epimerase an enzyme converting glucuronic acid to iduronic acid in heparan sulfate/heparin biosynthesis.	Heparitin Sulfate	81-96	glucuronyl C5-epimerase	Mus musculus	0-23
20807641-1	2010	The glucuronyl C5 epimerase (HSepi) is one of the modification enzymes involved in biosynthesis of heparan sulfate (HS) and heparin, catalyzing the epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) at polymer level.	Heparitin Sulfate	99-114	glucuronyl C5-epimerase	Mus musculus	4-27
20807641-1	2010	The glucuronyl C5 epimerase (HSepi) is one of the modification enzymes involved in biosynthesis of heparan sulfate (HS) and heparin, catalyzing the epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) at polymer level.	Heparitin Sulfate	99-114	glucuronyl C5-epimerase	Mus musculus	29-34
20431264-2	2010	Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate.	Heparitin Sulfate	44-59	midkine	Mus musculus	0-7
20807645-1	2010	Vascular endothelial cells (ECs) produce anticoagulant heparan sulfate (HSAT+)-a small subpopulation of heparan sulfate (HS) containing a specific pentasaccharide motif with high affinity for plasma antithrombin (AT).	Heparitin Sulfate	55-70	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	199-211
20807641-1	2010	The glucuronyl C5 epimerase (HSepi) is one of the modification enzymes involved in biosynthesis of heparan sulfate (HS) and heparin, catalyzing the epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) at polymer level.	Heparitin Sulfate	29-31	glucuronyl C5-epimerase	Mus musculus	4-27
20807645-1	2010	Vascular endothelial cells (ECs) produce anticoagulant heparan sulfate (HSAT+)-a small subpopulation of heparan sulfate (HS) containing a specific pentasaccharide motif with high affinity for plasma antithrombin (AT).	Heparitin Sulfate	104-119	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	199-211
20807645-1	2010	Vascular endothelial cells (ECs) produce anticoagulant heparan sulfate (HSAT+)-a small subpopulation of heparan sulfate (HS) containing a specific pentasaccharide motif with high affinity for plasma antithrombin (AT).	Heparitin Sulfate	72-74	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	199-211
19858217-0	2009	A turn-like structure "KKPE" segment mediates the specific binding of viral protein A27 to heparin and heparan sulfate on cell surfaces.	Heparitin Sulfate	103-118	immunoglobulin kappa variable 3-20	Homo sapiens	84-87
19858217-1	2009	Vaccinia viral envelope protein A27 (110 amino acids) specifically interacts with heparin (HP) or heparan sulfate (HS) proteoglycans for cell surface attachment.	Heparitin Sulfate	98-113	immunoglobulin kappa variable 3-20	Homo sapiens	32-35
19858217-1	2009	Vaccinia viral envelope protein A27 (110 amino acids) specifically interacts with heparin (HP) or heparan sulfate (HS) proteoglycans for cell surface attachment.	Heparitin Sulfate	115-117	immunoglobulin kappa variable 3-20	Homo sapiens	32-35
19858217-9	2009	We conclude that a turn-like structure introduced by the KKPE segment in vaccinia viral envelope protein A27 is responsible for its specific binding to HP and to HS on cell surfaces.	Heparitin Sulfate	162-164	immunoglobulin kappa variable 3-20	Homo sapiens	105-108
19695308-7	2009	The pre-incubation of HeLa cells with heparin or with anti-heparan sulfate antibodies or with beta-d-xyloside inhibited SDF-1/CXCL12-mediated cell invasion.	Heparitin Sulfate	59-74	C-X-C motif chemokine ligand 12	Homo sapiens	120-125
19837661-6	2009	Modeling of the antibodies demonstrates that they possess highly basic CDR3 and surrounding surfaces, presenting a number of possible orientations for HS binding.	Heparitin Sulfate	151-153	CDR3	Homo sapiens	71-75
19850926-0	2009	Mutation in the heparan sulfate biosynthesis enzyme EXT1 influences growth factor signaling and fibroblast interactions with the extracellular matrix.	Heparitin Sulfate	16-31	exostosin glycosyltransferase 1	Mus musculus	52-56
19966216-0	2009	PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation.	Heparitin Sulfate	64-79	platelet derived growth factor subunit A L homeolog	Xenopus laevis	0-6
19966216-0	2009	PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation.	Heparitin Sulfate	64-79	fibronectin 1 S homeolog	Xenopus laevis	25-36
19894734-4	2009	Unmodified Hya, chondroitin-sulfate (CS), and heparan sulfate (HS) showed significantly less binding affinity.	Heparitin Sulfate	63-65	lysine demethylase 5D	Homo sapiens	11-14
19695308-7	2009	The pre-incubation of HeLa cells with heparin or with anti-heparan sulfate antibodies or with beta-d-xyloside inhibited SDF-1/CXCL12-mediated cell invasion.	Heparitin Sulfate	59-74	C-X-C motif chemokine ligand 12	Homo sapiens	126-132
19909247-2	2009	This domain allows these isoforms to interact with and localize to the HS (heparan sulfate)-rich extracellular matrix, and bind to the co-receptor Nrp-1 (neuropilin-1).	Heparitin Sulfate	71-73	neuropilin 1	Mus musculus	147-152
19909247-2	2009	This domain allows these isoforms to interact with and localize to the HS (heparan sulfate)-rich extracellular matrix, and bind to the co-receptor Nrp-1 (neuropilin-1).	Heparitin Sulfate	71-73	neuropilin 1	Mus musculus	154-166
19479373-1	2009	Glypican-1 is a glycosylphosphatidylinositol anchored cell surface S-nitrosylated heparan sulfate proteoglycan that is processed by nitric oxide dependent degradation of its side chains.	Heparitin Sulfate	82-97	glypican 1	Homo sapiens	0-10
19909247-2	2009	This domain allows these isoforms to interact with and localize to the HS (heparan sulfate)-rich extracellular matrix, and bind to the co-receptor Nrp-1 (neuropilin-1).	Heparitin Sulfate	75-90	neuropilin 1	Mus musculus	147-152
19909247-2	2009	This domain allows these isoforms to interact with and localize to the HS (heparan sulfate)-rich extracellular matrix, and bind to the co-receptor Nrp-1 (neuropilin-1).	Heparitin Sulfate	75-90	neuropilin 1	Mus musculus	154-166
19620133-12	2009	Western blotting for HS showed significant reduction in expression of HS, one of the main glycosaminoglycans in the glycocalyx, with C-reactive protein treatment.	Heparitin Sulfate	21-23	C-reactive protein	Homo sapiens	133-151
19839753-1	2009	Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder most frequently caused by the EXT1 and EXT2 gene mutations resulting in reduction or absence of heparan sulfate (HS) in the exostotic cartilage cap.	Heparitin Sulfate	175-190	exostosin glycosyltransferase 1	Homo sapiens	109-113
19839753-1	2009	Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder most frequently caused by the EXT1 and EXT2 gene mutations resulting in reduction or absence of heparan sulfate (HS) in the exostotic cartilage cap.	Heparitin Sulfate	175-190	exostosin glycosyltransferase 2	Homo sapiens	118-122
19839753-1	2009	Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder most frequently caused by the EXT1 and EXT2 gene mutations resulting in reduction or absence of heparan sulfate (HS) in the exostotic cartilage cap.	Heparitin Sulfate	192-194	exostosin glycosyltransferase 1	Homo sapiens	109-113
19839753-1	2009	Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder most frequently caused by the EXT1 and EXT2 gene mutations resulting in reduction or absence of heparan sulfate (HS) in the exostotic cartilage cap.	Heparitin Sulfate	192-194	exostosin glycosyltransferase 2	Homo sapiens	118-122
19839758-1	2009	Mucopolysaccharidosis type I (MPS I) is an autosomal recessive disorder that results from a deficiency in alpha-L-iduronidase (IDUA), which is involved in the degradation of dermatan and heparan sulfates.	Heparitin Sulfate	187-203	alpha-L-iduronidase	Homo sapiens	106-125
19839758-1	2009	Mucopolysaccharidosis type I (MPS I) is an autosomal recessive disorder that results from a deficiency in alpha-L-iduronidase (IDUA), which is involved in the degradation of dermatan and heparan sulfates.	Heparitin Sulfate	187-203	alpha-L-iduronidase	Homo sapiens	127-131
19717493-8	2009	Altogether, these data suggest that GAG mimetics may compete with cellular heparan sulfate chains for the binding to SDF-1/CXCL12 and may affect heparanase expression, leading to reduced SDF-1/CXCL12 mediated in vitro chemotaxis and growth of hepatoma cells.	Heparitin Sulfate	75-90	C-X-C motif chemokine ligand 12	Homo sapiens	117-122
19479373-2	2009	Cell surface-bound glypican-1 becomes internalized and recycles via endosomes, where the heparan sulphate chains undergo nitric oxide and copper dependent autocleavage at N-unsubstituted glucosamines, back to the Golgi.	Heparitin Sulfate	89-105	glypican 1	Homo sapiens	19-29
19955948-1	2009	Heparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains of heparan sulfate proteoglycans, the major proteoglycans in the extracellular matrix and cell surfaces.	Heparitin Sulfate	59-74	heparanase	Homo sapiens	0-10
19717493-8	2009	Altogether, these data suggest that GAG mimetics may compete with cellular heparan sulfate chains for the binding to SDF-1/CXCL12 and may affect heparanase expression, leading to reduced SDF-1/CXCL12 mediated in vitro chemotaxis and growth of hepatoma cells.	Heparitin Sulfate	75-90	C-X-C motif chemokine ligand 12	Homo sapiens	123-129
19717493-8	2009	Altogether, these data suggest that GAG mimetics may compete with cellular heparan sulfate chains for the binding to SDF-1/CXCL12 and may affect heparanase expression, leading to reduced SDF-1/CXCL12 mediated in vitro chemotaxis and growth of hepatoma cells.	Heparitin Sulfate	75-90	C-X-C motif chemokine ligand 12	Homo sapiens	187-192
19717493-8	2009	Altogether, these data suggest that GAG mimetics may compete with cellular heparan sulfate chains for the binding to SDF-1/CXCL12 and may affect heparanase expression, leading to reduced SDF-1/CXCL12 mediated in vitro chemotaxis and growth of hepatoma cells.	Heparitin Sulfate	75-90	C-X-C motif chemokine ligand 12	Homo sapiens	193-199
19675100-5	2009	We observed that while heparin and HS changed the mAcP aggregation kinetic profile, the monosaccharide derivatives had no effect, whatever their concentration could be and both when they are studied separately or in combination.	Heparitin Sulfate	35-37	vitamin A enhanced cleft palate	Mus musculus	50-54
19675100-8	2009	We propose a model in which heparin and HS promote mAcP aggregation through a scaffolding-based mechanism, in which the regularly spaced sulphate moieties of the polymer interact with mAcP molecules increasing their local concentration and facilitating their orientation.	Heparitin Sulfate	40-42	vitamin A enhanced cleft palate	Mus musculus	51-55
19675100-8	2009	We propose a model in which heparin and HS promote mAcP aggregation through a scaffolding-based mechanism, in which the regularly spaced sulphate moieties of the polymer interact with mAcP molecules increasing their local concentration and facilitating their orientation.	Heparitin Sulfate	40-42	vitamin A enhanced cleft palate	Mus musculus	184-188
19749739-1	2009	Enzymatic activity responsible for the cleavage of heparan sulfate, commonly known as heparanase, is abundant in tumor-derived cells.	Heparitin Sulfate	51-66	heparanase	Homo sapiens	86-96
19465079-9	2009	Thus, the N-terminal portion of B-CK is critical to mediate its affinity to heparin and control enzyme activity, which may be important for regulating energy metabolism in neural tissues such as brain and retina, unique organs abundant in heparan sulfates.	Heparitin Sulfate	239-255	creatine kinase B	Gallus gallus	32-36
19749739-2	2009	Heparanase cleaves heparan sulfate side chains, presumably at sites of low sulfation, thus facilitating structural alterations of the extracellular matrix and basement membrane underlying epithelial and endothelial cells.	Heparitin Sulfate	19-34	heparanase	Homo sapiens	0-10
19749739-3	2009	Traditionally, heparanase activity was correlated with the metastatic potential of tumor-derived cells, attributed to enhanced cell dissemination as a consequence of heparan sulfate cleavage and remodeling of the extracellular matrix barrier.	Heparitin Sulfate	166-181	heparanase	Homo sapiens	15-25
19775117-0	2009	Chemical and thermal unfolding of glypican-1: protective effect of heparan sulfate against heat-induced irreversible aggregation.	Heparitin Sulfate	67-82	glypican 1	Homo sapiens	34-44
19841260-2	2009	VEGF in mice is produced as three isoforms, VEGF120, VEGF164, and VEGF188, that differ in their ability to bind heparan sulfate proteoglycan.	Heparitin Sulfate	112-127	vascular endothelial growth factor A	Mus musculus	0-4
19251947-4	2009	To confirm that NE binding to heparan sulfate (HS) components of Syn-1 limits the antielastase effect, recombinant human Syn-1 was recovered from stable Syn-1 transfectants of a human B-lymphoid cell line (ARH-77).	Heparitin Sulfate	30-45	elastase, neutrophil expressed	Homo sapiens	16-18
19251947-4	2009	To confirm that NE binding to heparan sulfate (HS) components of Syn-1 limits the antielastase effect, recombinant human Syn-1 was recovered from stable Syn-1 transfectants of a human B-lymphoid cell line (ARH-77).	Heparitin Sulfate	47-49	elastase, neutrophil expressed	Homo sapiens	16-18
19251947-4	2009	To confirm that NE binding to heparan sulfate (HS) components of Syn-1 limits the antielastase effect, recombinant human Syn-1 was recovered from stable Syn-1 transfectants of a human B-lymphoid cell line (ARH-77).	Heparitin Sulfate	47-49	synapsin I	Homo sapiens	65-70
19251947-5	2009	Western ligand blot confirmed that NE bound to HS moieties and alpha(1)-AT to the core protein of the recombinant product.	Heparitin Sulfate	47-49	elastase, neutrophil expressed	Homo sapiens	35-37
19251947-8	2009	We conclude that the HS moiety of shed Syn-1 binds and restricts NE from inhibition by alpha(1)-AT.	Heparitin Sulfate	21-23	synapsin I	Homo sapiens	39-44
19251947-8	2009	We conclude that the HS moiety of shed Syn-1 binds and restricts NE from inhibition by alpha(1)-AT.	Heparitin Sulfate	21-23	elastase, neutrophil expressed	Homo sapiens	65-67
19251947-8	2009	We conclude that the HS moiety of shed Syn-1 binds and restricts NE from inhibition by alpha(1)-AT.	Heparitin Sulfate	21-23	serpin family A member 1	Homo sapiens	87-98
19598263-5	2009	Heparin sulfate-like proteoglycans on tumor cell surface are implicated in the adhesion of A375 cells to integrin alpha(IIb)beta(3).	Heparitin Sulfate	0-15	integrin alpha-IIb	Cricetulus griseus	105-123
19903770-8	2009	Previous studies have shown that zinc-dependent binding of the His/Pro-rich domain of HRG to heparan sulfate on endothelial cells is required for inhibition of angiogenesis.	Heparitin Sulfate	93-108	histidine rich glycoprotein	Homo sapiens	86-89
19936054-2	2009	PrP(C) associates with lipid rafts through its glycosyl-phosphatidylinositol (GPI) anchor and a region in its N-terminal domain which also binds to heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	148-163	prion protein	Mus musculus	0-6
19691449-6	2009	37LRP, but not 67LR, binds to heparan sulfate.	Heparitin Sulfate	30-45	ribosomal protein SA	Homo sapiens	0-5
19691449-7	2009	The binding of 37LRP to heparan sulfate did not affect the interaction of 37LRP with laminin.	Heparitin Sulfate	24-39	ribosomal protein SA	Homo sapiens	15-20
19691449-8	2009	In contrast, heparan sulfate reduces the extent of binding of laminin to 67LR.	Heparitin Sulfate	13-28	ribosomal protein SA	Homo sapiens	73-77
19800307-2	2009	As previous data reported that hyaluronan (HA) and heparan sulfate (HS) may interact with TLR-4, the aim of this study was to investigate whether glycosaminoglycans (GAGs) may modulate the TLR-4 receptor in a model of LPS-induced inflammatory cytokines in mouse chondrocytes.	Heparitin Sulfate	51-66	toll-like receptor 4	Mus musculus	90-95
19800307-2	2009	As previous data reported that hyaluronan (HA) and heparan sulfate (HS) may interact with TLR-4, the aim of this study was to investigate whether glycosaminoglycans (GAGs) may modulate the TLR-4 receptor in a model of LPS-induced inflammatory cytokines in mouse chondrocytes.	Heparitin Sulfate	68-70	toll-like receptor 4	Mus musculus	90-95
19629389-1	2009	Heparan sulfate proteoglycans are a remarkably diverse family of glycosaminoglycan-bearing protein cores that include the syndecans, the glypicans, perlecan, agrin, and collagen XVIII.	Heparitin Sulfate	0-15	agrin	Homo sapiens	158-163
19629389-1	2009	Heparan sulfate proteoglycans are a remarkably diverse family of glycosaminoglycan-bearing protein cores that include the syndecans, the glypicans, perlecan, agrin, and collagen XVIII.	Heparitin Sulfate	0-15	collagen type XVIII alpha 1 chain	Homo sapiens	169-183
19667120-0	2009	Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12.	Heparitin Sulfate	57-72	chemokine (C-X-C motif) ligand 12	Mus musculus	81-87
20394677-1	2009	The extracellular sulfatases Sulf1 and Sulf2 remove specific 6-O-sulfate groups from heparan sulfate, thereby modulating numerous signalling pathways underlying development and homeostasis.	Heparitin Sulfate	85-100	sulfatase 1	Mus musculus	29-34
20394677-1	2009	The extracellular sulfatases Sulf1 and Sulf2 remove specific 6-O-sulfate groups from heparan sulfate, thereby modulating numerous signalling pathways underlying development and homeostasis.	Heparitin Sulfate	85-100	sulfatase 2	Mus musculus	39-44
19726670-5	2009	Cells deficient in HS biosynthesis showed increased activity of two Rho GTPases, RhoA and Cdc42, both of which showed a correlation between increased activity and increased cell-cell fusion.	Heparitin Sulfate	19-21	ras homolog family member A	Homo sapiens	81-85
19726670-5	2009	Cells deficient in HS biosynthesis showed increased activity of two Rho GTPases, RhoA and Cdc42, both of which showed a correlation between increased activity and increased cell-cell fusion.	Heparitin Sulfate	19-21	cell division cycle 42	Homo sapiens	90-95
19775117-4	2009	Recombinant glypican-1 was expressed as two glycoforms, one as proteoglycan substituted with heparan sulfate chains and one as the core protein devoid of glycosaminoglycans.	Heparitin Sulfate	93-108	glypican 1	Homo sapiens	12-22
19657062-0	2009	Epac increases melanoma cell migration by a heparan sulfate-related mechanism.	Heparitin Sulfate	44-59	Rap guanine nucleotide exchange factor 3	Homo sapiens	0-4
19696445-0	2009	Heparan sulfate proteoglycan modulation of Wnt5A signal transduction in metastatic melanoma cells.	Heparitin Sulfate	0-15	Wnt family member 5A	Homo sapiens	43-48
19666466-0	2009	Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain.	Heparitin Sulfate	76-91	sulfatase 1	Homo sapiens	40-45
19666466-1	2009	The extracellular sulfatases Sulf1 and Sulf2 remodel the 6O-sulfation state of heparan sulfate proteoglycans on the cell surface, thereby modulating growth factor signaling.	Heparitin Sulfate	79-94	sulfatase 1	Homo sapiens	29-34
19666466-1	2009	The extracellular sulfatases Sulf1 and Sulf2 remodel the 6O-sulfation state of heparan sulfate proteoglycans on the cell surface, thereby modulating growth factor signaling.	Heparitin Sulfate	79-94	sulfatase 2	Homo sapiens	39-44
19657062-9	2009	Epac-induced cell migration was also regulated by the production of heparan sulfate, a major extracellular matrix.	Heparitin Sulfate	68-83	Rap guanine nucleotide exchange factor 3	Homo sapiens	0-4
19657062-10	2009	Epac-induced heparan sulfate production was attributable to the increased expression of N-deacetylase/N-sulfotransferase-1 (NDST-1) accompanied by an increased NDST-1 translation rate.	Heparitin Sulfate	13-28	Rap guanine nucleotide exchange factor 3	Homo sapiens	0-4
19692651-1	2009	Focus on "Epac increases melanoma cell migration by a heparin sulfate-related mechanism".	Heparitin Sulfate	54-69	Rap guanine nucleotide exchange factor 3	Homo sapiens	10-14
19657062-10	2009	Epac-induced heparan sulfate production was attributable to the increased expression of N-deacetylase/N-sulfotransferase-1 (NDST-1) accompanied by an increased NDST-1 translation rate.	Heparitin Sulfate	13-28	N-deacetylase and N-sulfotransferase 1	Homo sapiens	88-122
19657062-10	2009	Epac-induced heparan sulfate production was attributable to the increased expression of N-deacetylase/N-sulfotransferase-1 (NDST-1) accompanied by an increased NDST-1 translation rate.	Heparitin Sulfate	13-28	N-deacetylase and N-sulfotransferase 1	Homo sapiens	124-130
19657062-10	2009	Epac-induced heparan sulfate production was attributable to the increased expression of N-deacetylase/N-sulfotransferase-1 (NDST-1) accompanied by an increased NDST-1 translation rate.	Heparitin Sulfate	13-28	N-deacetylase and N-sulfotransferase 1	Homo sapiens	160-166
19657062-12	2009	Taken together, these data indicate that Epac regulates melanoma cell migration/metastasis mostly via syndecan-2 translocation and heparan sulfate production.	Heparitin Sulfate	131-146	Rap guanine nucleotide exchange factor 3	Homo sapiens	41-45
19638625-7	2009	These data show that syndecan-1 shedding is a critical endogenous mechanism that facilitates the resolution of neutrophilic inflammation by aiding the clearance of proinflammatory chemokines in a heparan sulfate-dependent manner.	Heparitin Sulfate	196-211	syndecan 1	Mus musculus	21-31
19549924-0	2009	Heparan sulfate promotes the aggregation of HDL-associated serum amyloid A: evidence for a proamyloidogenic histidine molecular switch.	Heparitin Sulfate	0-15	serum amyloid A1 cluster	Homo sapiens	59-74
19549924-5	2009	A sequence motif in SAA responsible for this conversion was identified that contains a pH-sensitive heparin/HS-binding site, functions as a ligand for a cell surface receptor, and acts as a structural focal point for SAA aggregation.	Heparitin Sulfate	108-110	serum amyloid A1 cluster	Homo sapiens	20-23
19549924-5	2009	A sequence motif in SAA responsible for this conversion was identified that contains a pH-sensitive heparin/HS-binding site, functions as a ligand for a cell surface receptor, and acts as a structural focal point for SAA aggregation.	Heparitin Sulfate	108-110	serum amyloid A1 cluster	Homo sapiens	217-220
19540587-2	2009	Endothelialisation and platelet adhesion to purified endothelial cell-derived perlecan, the major heparan sulfate (HS) proteoglycan in basement membranes, were investigated using in vivo and in vitro assays.	Heparitin Sulfate	98-113	perlecan	Ovis aries	78-86
19540587-2	2009	Endothelialisation and platelet adhesion to purified endothelial cell-derived perlecan, the major heparan sulfate (HS) proteoglycan in basement membranes, were investigated using in vivo and in vitro assays.	Heparitin Sulfate	115-117	perlecan	Ovis aries	78-86
19540587-6	2009	Perlecan was found to be anti-adhesive for platelets, however after removal of the HS chains attached to perlecan, platelet adhesion and aggregation were supported.	Heparitin Sulfate	83-85	perlecan	Ovis aries	0-8
19540587-6	2009	Perlecan was found to be anti-adhesive for platelets, however after removal of the HS chains attached to perlecan, platelet adhesion and aggregation were supported.	Heparitin Sulfate	83-85	perlecan	Ovis aries	105-113
19777561-1	2009	The heparan sulfate proteoglycan Glypican 4 (Gpc4) is part of the Wnt/planar cell polarity pathway, which is required for convergence and extension during zebrafish gastrulation.	Heparitin Sulfate	4-19	glypican 4	Danio rerio	33-43
19777561-1	2009	The heparan sulfate proteoglycan Glypican 4 (Gpc4) is part of the Wnt/planar cell polarity pathway, which is required for convergence and extension during zebrafish gastrulation.	Heparitin Sulfate	4-19	glypican 4	Danio rerio	45-49
19800217-3	2009	In this survey, some structural aspects of the chemokine-heparan sulphate interface are described, with a focus on CXCL12; alternative splicing of which finely tunes its affinity for glycosaminoglycans, through the generation of an intrinsically disordered peptides, and on recent biochemical observations that shed light on both the fine structure and the general topology of the heparan sulphate domains that chemokines recognize.	Heparitin Sulfate	57-73	C-X-C motif chemokine ligand 12	Homo sapiens	115-121
19800217-3	2009	In this survey, some structural aspects of the chemokine-heparan sulphate interface are described, with a focus on CXCL12; alternative splicing of which finely tunes its affinity for glycosaminoglycans, through the generation of an intrinsically disordered peptides, and on recent biochemical observations that shed light on both the fine structure and the general topology of the heparan sulphate domains that chemokines recognize.	Heparitin Sulfate	381-397	C-X-C motif chemokine ligand 12	Homo sapiens	115-121
19549924-4	2009	HS causes the remodeling of HDL-SAA at mildly acidic pH, producing SAA-rich aggregates.	Heparitin Sulfate	0-2	serum amyloid A1 cluster	Homo sapiens	32-35
19549924-4	2009	HS causes the remodeling of HDL-SAA at mildly acidic pH, producing SAA-rich aggregates.	Heparitin Sulfate	0-2	serum amyloid A1 cluster	Homo sapiens	67-70
19710461-1	2009	The effect of targeted inactivation of the gene encoding N-deacetylase/N-sulfotransferase-1 (Ndst1), a key enzyme involved in the biosynthesis of heparan sulfate (HS) chains, on the inflammatory response associated with allergic inflammation in a murine model of OVA-induced acute airway inflammation was investigated.	Heparitin Sulfate	146-161	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	57-91
19643179-2	2009	For this purpose, we first established a novel method of purifying recombinant FLAG-tagged TIMP-3 and its inhibitory N-terminal domain (N-TIMP-3) by treating transfected HEK293 cells with sodium chlorate to prevent heparan sulfate proteoglycan-mediated TIMP-3 internalization.	Heparitin Sulfate	215-230	TIMP metallopeptidase inhibitor 3	Homo sapiens	91-97
19643179-2	2009	For this purpose, we first established a novel method of purifying recombinant FLAG-tagged TIMP-3 and its inhibitory N-terminal domain (N-TIMP-3) by treating transfected HEK293 cells with sodium chlorate to prevent heparan sulfate proteoglycan-mediated TIMP-3 internalization.	Heparitin Sulfate	215-230	TIMP metallopeptidase inhibitor 3	Homo sapiens	138-144
19643179-2	2009	For this purpose, we first established a novel method of purifying recombinant FLAG-tagged TIMP-3 and its inhibitory N-terminal domain (N-TIMP-3) by treating transfected HEK293 cells with sodium chlorate to prevent heparan sulfate proteoglycan-mediated TIMP-3 internalization.	Heparitin Sulfate	215-230	TIMP metallopeptidase inhibitor 3	Homo sapiens	138-144
19596853-2	2009	Here we demonstrate a simple method for rapid isolation of proteoglycans (RIP) employing phenol/guanidine/chloroform reagent to purify heparan sulfate (HS) PGs quantitatively from various tissues and cells.	Heparitin Sulfate	135-150	regulation of phenobarbitol-inducible P450	Mus musculus	74-77
19596853-2	2009	Here we demonstrate a simple method for rapid isolation of proteoglycans (RIP) employing phenol/guanidine/chloroform reagent to purify heparan sulfate (HS) PGs quantitatively from various tissues and cells.	Heparitin Sulfate	152-154	regulation of phenobarbitol-inducible P450	Mus musculus	74-77
19596853-7	2009	These data demonstrate that RIP will underpin emerging efforts to develop glycomics profiling strategies for HS and other glycosaminoglycans to explore their structure-function relationships in complex biological systems.	Heparitin Sulfate	109-111	regulation of phenobarbitol-inducible P450	Mus musculus	28-31
19710461-1	2009	The effect of targeted inactivation of the gene encoding N-deacetylase/N-sulfotransferase-1 (Ndst1), a key enzyme involved in the biosynthesis of heparan sulfate (HS) chains, on the inflammatory response associated with allergic inflammation in a murine model of OVA-induced acute airway inflammation was investigated.	Heparitin Sulfate	146-161	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	93-98
19710461-1	2009	The effect of targeted inactivation of the gene encoding N-deacetylase/N-sulfotransferase-1 (Ndst1), a key enzyme involved in the biosynthesis of heparan sulfate (HS) chains, on the inflammatory response associated with allergic inflammation in a murine model of OVA-induced acute airway inflammation was investigated.	Heparitin Sulfate	163-165	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	57-91
19710461-1	2009	The effect of targeted inactivation of the gene encoding N-deacetylase/N-sulfotransferase-1 (Ndst1), a key enzyme involved in the biosynthesis of heparan sulfate (HS) chains, on the inflammatory response associated with allergic inflammation in a murine model of OVA-induced acute airway inflammation was investigated.	Heparitin Sulfate	163-165	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	93-98
19734912-5	2009	The linkage between the CD4 mimetic and the heparan sulfate derivative provides strong cooperative effects, resulting in low-nanomolar antiviral activity toward both CCR5- and CXCR4-tropic HIV-1 strains.	Heparitin Sulfate	44-59	CD4 molecule	Homo sapiens	24-27
19740307-5	2009	The induction of IL-6 and TNF-alpha production was related rather to the fixation of the spike (S) protein of MHV3 on Toll-like receptor 2 (TLR2) in regions enriched in heparan sulphate and did not rely on viral replication, as demonstrated with denatured S protein and UV-inactivated virus.	Heparitin Sulfate	169-185	interleukin 6	Mus musculus	17-21
19755711-2	2009	Here, we show that differences in the binding of fibroblast growth factor 7 (FGF7) and FGF10 to heparan sulfate (HS) underlie the formation of different gradients that dictate distinct activities during branching morphogenesis.	Heparitin Sulfate	96-111	fibroblast growth factor 7	Homo sapiens	49-75
19755711-2	2009	Here, we show that differences in the binding of fibroblast growth factor 7 (FGF7) and FGF10 to heparan sulfate (HS) underlie the formation of different gradients that dictate distinct activities during branching morphogenesis.	Heparitin Sulfate	96-111	fibroblast growth factor 7	Homo sapiens	77-81
19755711-2	2009	Here, we show that differences in the binding of fibroblast growth factor 7 (FGF7) and FGF10 to heparan sulfate (HS) underlie the formation of different gradients that dictate distinct activities during branching morphogenesis.	Heparitin Sulfate	96-111	fibroblast growth factor 10	Homo sapiens	87-92
19755711-2	2009	Here, we show that differences in the binding of fibroblast growth factor 7 (FGF7) and FGF10 to heparan sulfate (HS) underlie the formation of different gradients that dictate distinct activities during branching morphogenesis.	Heparitin Sulfate	113-115	fibroblast growth factor 7	Homo sapiens	49-75
19755711-2	2009	Here, we show that differences in the binding of fibroblast growth factor 7 (FGF7) and FGF10 to heparan sulfate (HS) underlie the formation of different gradients that dictate distinct activities during branching morphogenesis.	Heparitin Sulfate	113-115	fibroblast growth factor 7	Homo sapiens	77-81
19553347-10	2009	nef/CIHPs showed a 60% decrease in apoE and a 90% reduction in heparan sulfate mRNA expression.	Heparitin Sulfate	63-78	S100 calcium binding protein B	Homo sapiens	0-3
19410646-1	2009	In partnership exclusively with the epithelial FGFR2IIIb isotype and a structurally-specific heparan sulfate motif, stromal-derived FGF7 delivers both growth-promoting and growth-limiting differentiation signals to epithelial cells that promote cellular homeostasis between stromal and epithelial compartments.	Heparitin Sulfate	93-108	fibroblast growth factor 7	Homo sapiens	132-136
19755711-2	2009	Here, we show that differences in the binding of fibroblast growth factor 7 (FGF7) and FGF10 to heparan sulfate (HS) underlie the formation of different gradients that dictate distinct activities during branching morphogenesis.	Heparitin Sulfate	113-115	fibroblast growth factor 10	Homo sapiens	87-92
19740307-5	2009	The induction of IL-6 and TNF-alpha production was related rather to the fixation of the spike (S) protein of MHV3 on Toll-like receptor 2 (TLR2) in regions enriched in heparan sulphate and did not rely on viral replication, as demonstrated with denatured S protein and UV-inactivated virus.	Heparitin Sulfate	169-185	toll-like receptor 2	Mus musculus	140-144
19470522-2	2009	By using glycan microarray analysis and other assays, we found that human C21orf63 interacts with heparin and to a lesser extent with heparan sulphate.	Heparitin Sulfate	134-150	eva-1 homolog C	Homo sapiens	74-82
19564416-0	2009	Homodimerization controls the fibroblast growth factor 9 subfamily"s receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix.	Heparitin Sulfate	90-105	fibroblast growth factor 9	Homo sapiens	30-56
19564416-5	2009	Interestingly, the monomeric ligands exhibit reduced heparin binding, resulting in their increased radii of heparan sulfate-dependent diffusion and biologic action, as evidenced by the wider dilation area of ex vivo lung cultures in response to implanted mutant FGF9-loaded beads.	Heparitin Sulfate	108-123	fibroblast growth factor 9	Homo sapiens	262-266
19602586-7	2009	We have further shown that overexpression of EcSOD decreased accumulation of vascular endothelial growth factor in the culture medium and increased the level of intact cell surface-associated heparan sulfate, thus implicating inhibition of heparanase expression as a potential mechanism.	Heparitin Sulfate	192-207	superoxide dismutase 3	Homo sapiens	45-50
19502598-3	2009	We used surface plasmon resonance assays to characterize interactions between endostatin, integrins, and heparin/heparan sulfate.	Heparitin Sulfate	113-128	collagen type XVIII alpha 1 chain	Homo sapiens	78-88
19502598-5	2009	Two arginine residues (Arg27 and Arg139) are crucial for the binding of endostatin to integrins and to heparin/heparan sulfate, suggesting that endostatin would not bind simultaneously to integrins and to heparan sulfate.	Heparitin Sulfate	111-126	collagen type XVIII alpha 1 chain	Homo sapiens	72-82
19502598-5	2009	Two arginine residues (Arg27 and Arg139) are crucial for the binding of endostatin to integrins and to heparin/heparan sulfate, suggesting that endostatin would not bind simultaneously to integrins and to heparan sulfate.	Heparitin Sulfate	205-220	collagen type XVIII alpha 1 chain	Homo sapiens	72-82
19502598-9	2009	The direct binding between integrins and heparin/heparan sulfate might explain why both heparan sulfate and alpha5beta1 integrin are required for the localization of endostatin in endothelial cell lipid rafts.	Heparitin Sulfate	49-64	collagen type XVIII alpha 1 chain	Homo sapiens	166-176
19502598-9	2009	The direct binding between integrins and heparin/heparan sulfate might explain why both heparan sulfate and alpha5beta1 integrin are required for the localization of endostatin in endothelial cell lipid rafts.	Heparitin Sulfate	88-103	collagen type XVIII alpha 1 chain	Homo sapiens	166-176
19409721-4	2009	The proposed mechanism of action involves (i) interaction with gp120 and thereby preventing binding to CD4 and (ii) competitive binding with the viral glycoprotein and inhibit the glycoprotein - cell surface glyocosaminoglycan Heparan Sulfate (HS) interaction.	Heparitin Sulfate	227-242	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	63-68
19456850-6	2009	Binding of APRIL or TACI-Fc was abrogated by heparin or cell pretreatment with heparitinase, which cleaves heparan sulfate chains.	Heparitin Sulfate	107-122	TNF receptor superfamily member 13B	Homo sapiens	20-24
19409721-4	2009	The proposed mechanism of action involves (i) interaction with gp120 and thereby preventing binding to CD4 and (ii) competitive binding with the viral glycoprotein and inhibit the glycoprotein - cell surface glyocosaminoglycan Heparan Sulfate (HS) interaction.	Heparitin Sulfate	227-242	CD4 molecule	Homo sapiens	103-106
19409721-4	2009	The proposed mechanism of action involves (i) interaction with gp120 and thereby preventing binding to CD4 and (ii) competitive binding with the viral glycoprotein and inhibit the glycoprotein - cell surface glyocosaminoglycan Heparan Sulfate (HS) interaction.	Heparitin Sulfate	244-246	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	63-68
19409721-4	2009	The proposed mechanism of action involves (i) interaction with gp120 and thereby preventing binding to CD4 and (ii) competitive binding with the viral glycoprotein and inhibit the glycoprotein - cell surface glyocosaminoglycan Heparan Sulfate (HS) interaction.	Heparitin Sulfate	244-246	CD4 molecule	Homo sapiens	103-106
19398718-3	2009	N-sulfation of heparan sulfate (HS) is required for platelet-derived growth factor B (PDGF-B) retention and platelet-derived growth factor receptor-beta (PDGFR-beta) signaling during MC recruitment.	Heparitin Sulfate	15-30	platelet derived growth factor subunit B	Homo sapiens	52-84
19538537-4	2009	This heparan sulfate proteoglycan can also link directly to the cytoskeleton through alpha-actinin, and can signal through protein kinase C. In turn, the pathway leads to RhoA and Rho kinases that control actomyosin contractility.	Heparitin Sulfate	5-20	actinin alpha 1	Homo sapiens	85-98
19398718-3	2009	N-sulfation of heparan sulfate (HS) is required for platelet-derived growth factor B (PDGF-B) retention and platelet-derived growth factor receptor-beta (PDGFR-beta) signaling during MC recruitment.	Heparitin Sulfate	15-30	platelet derived growth factor subunit B	Homo sapiens	86-92
19398718-3	2009	N-sulfation of heparan sulfate (HS) is required for platelet-derived growth factor B (PDGF-B) retention and platelet-derived growth factor receptor-beta (PDGFR-beta) signaling during MC recruitment.	Heparitin Sulfate	32-34	platelet derived growth factor receptor beta	Homo sapiens	154-164
19398718-9	2009	Our results suggest that HS is selectively required in a cell-autonomous manner, acting in cis with PDGFR-beta and TGF-beta receptors during induction/polarization and migration of local progenitor cells to the nascent vessel.	Heparitin Sulfate	25-27	platelet derived growth factor receptor beta	Homo sapiens	100-110
19398718-10	2009	Once MCs are in contact with the vessel, as during CNS vascularization, endothelial HS appears sufficient to facilitate PDGFR-beta activation in trans.	Heparitin Sulfate	84-86	platelet derived growth factor receptor beta	Homo sapiens	120-130
19398718-3	2009	N-sulfation of heparan sulfate (HS) is required for platelet-derived growth factor B (PDGF-B) retention and platelet-derived growth factor receptor-beta (PDGFR-beta) signaling during MC recruitment.	Heparitin Sulfate	15-30	platelet derived growth factor receptor beta	Homo sapiens	108-152
19398718-3	2009	N-sulfation of heparan sulfate (HS) is required for platelet-derived growth factor B (PDGF-B) retention and platelet-derived growth factor receptor-beta (PDGFR-beta) signaling during MC recruitment.	Heparitin Sulfate	15-30	platelet derived growth factor receptor beta	Homo sapiens	154-164
19398718-3	2009	N-sulfation of heparan sulfate (HS) is required for platelet-derived growth factor B (PDGF-B) retention and platelet-derived growth factor receptor-beta (PDGFR-beta) signaling during MC recruitment.	Heparitin Sulfate	32-34	platelet derived growth factor subunit B	Homo sapiens	52-84
19398718-3	2009	N-sulfation of heparan sulfate (HS) is required for platelet-derived growth factor B (PDGF-B) retention and platelet-derived growth factor receptor-beta (PDGFR-beta) signaling during MC recruitment.	Heparitin Sulfate	32-34	platelet derived growth factor subunit B	Homo sapiens	86-92
19398718-3	2009	N-sulfation of heparan sulfate (HS) is required for platelet-derived growth factor B (PDGF-B) retention and platelet-derived growth factor receptor-beta (PDGFR-beta) signaling during MC recruitment.	Heparitin Sulfate	32-34	platelet derived growth factor receptor beta	Homo sapiens	108-152
19399896-1	2009	Sanfilippo syndrome type B (MPS III B) is caused by a deficiency of alpha-N-acetylglucosaminidase enzyme (Naglu), leading to accumulation of heparan sulfate (HS), a glycosaminoglycan (GAG), within lysosomes and to eventual progressive cerebral and systemic multiple organ abnormalities.	Heparitin Sulfate	141-156	N-acetyl-alpha-glucosaminidase	Homo sapiens	28-37
19498462-4	2009	Slit2 D4 forms a homodimer using the conserved residues on its concave face, and can also bind to heparan sulphate.	Heparitin Sulfate	98-114	slit guidance ligand 2	Gallus gallus	0-5
19498462-5	2009	We observed that Slit2 D4 frequently results in growth cones with collapsed lamellipodia and that this effect can be inhibited by exogenously added heparan sulphate.	Heparitin Sulfate	148-164	slit guidance ligand 2	Gallus gallus	17-22
19498462-6	2009	Our results show that Slit2 D4-heparan sulphate binding contributes to a Slit-Robo signalling mechanism more intricate than previously thought.	Heparitin Sulfate	31-47	slit guidance ligand 2	Gallus gallus	22-27
19565481-1	2009	OBJECTIVE: We have previously identified in articular cartilage an abundant pool of the heparin-binding growth factor, fibroblast growth factor 2 (FGF-2), which is bound to the pericellular matrix heparan sulfate proteoglycan, perlecan.	Heparitin Sulfate	197-212	fibroblast growth factor 2	Mus musculus	119-145
19565481-1	2009	OBJECTIVE: We have previously identified in articular cartilage an abundant pool of the heparin-binding growth factor, fibroblast growth factor 2 (FGF-2), which is bound to the pericellular matrix heparan sulfate proteoglycan, perlecan.	Heparitin Sulfate	197-212	fibroblast growth factor 2	Mus musculus	147-152
19399896-1	2009	Sanfilippo syndrome type B (MPS III B) is caused by a deficiency of alpha-N-acetylglucosaminidase enzyme (Naglu), leading to accumulation of heparan sulfate (HS), a glycosaminoglycan (GAG), within lysosomes and to eventual progressive cerebral and systemic multiple organ abnormalities.	Heparitin Sulfate	141-156	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	68-104
19509472-8	2009	These findings suggest that HS is necessary for neural crest cells to form the anterior chamber via TGF-beta2 signaling.	Heparitin Sulfate	28-30	transforming growth factor, beta 2	Mus musculus	100-109
19399896-1	2009	Sanfilippo syndrome type B (MPS III B) is caused by a deficiency of alpha-N-acetylglucosaminidase enzyme (Naglu), leading to accumulation of heparan sulfate (HS), a glycosaminoglycan (GAG), within lysosomes and to eventual progressive cerebral and systemic multiple organ abnormalities.	Heparitin Sulfate	141-156	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	106-111
19399896-1	2009	Sanfilippo syndrome type B (MPS III B) is caused by a deficiency of alpha-N-acetylglucosaminidase enzyme (Naglu), leading to accumulation of heparan sulfate (HS), a glycosaminoglycan (GAG), within lysosomes and to eventual progressive cerebral and systemic multiple organ abnormalities.	Heparitin Sulfate	158-160	N-acetyl-alpha-glucosaminidase	Homo sapiens	28-37
19399896-1	2009	Sanfilippo syndrome type B (MPS III B) is caused by a deficiency of alpha-N-acetylglucosaminidase enzyme (Naglu), leading to accumulation of heparan sulfate (HS), a glycosaminoglycan (GAG), within lysosomes and to eventual progressive cerebral and systemic multiple organ abnormalities.	Heparitin Sulfate	158-160	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	68-104
19399896-1	2009	Sanfilippo syndrome type B (MPS III B) is caused by a deficiency of alpha-N-acetylglucosaminidase enzyme (Naglu), leading to accumulation of heparan sulfate (HS), a glycosaminoglycan (GAG), within lysosomes and to eventual progressive cerebral and systemic multiple organ abnormalities.	Heparitin Sulfate	158-160	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	106-111
19008778-4	2009	Endogenous ligands such as low-molecular hyaluronic acid, fibronectin, heat shock protein 70, and heparin sulfate were all found to be cleaved in the inflamed tissue and to activate TLR2 and TLR4, initiating an inflammatory response even in the absence of pathogens and infiltrating immune cells.	Heparitin Sulfate	98-113	toll like receptor 2	Homo sapiens	182-186
19008778-4	2009	Endogenous ligands such as low-molecular hyaluronic acid, fibronectin, heat shock protein 70, and heparin sulfate were all found to be cleaved in the inflamed tissue and to activate TLR2 and TLR4, initiating an inflammatory response even in the absence of pathogens and infiltrating immune cells.	Heparitin Sulfate	98-113	toll like receptor 4	Homo sapiens	191-195
19422911-8	2009	In support of this hypothesis we demonstrated that human perlecan bound in a heparan sulfate-dependent fashion to VEGF-A(165).	Heparitin Sulfate	77-92	heparan sulfate proteoglycan 2	Danio rerio	57-65
19473117-4	2009	Overexpression of FAM20B increased the amount of both chondroitin sulfate and heparan sulfate in HeLa cells, whereas the RNA interference of FAM20B resulted in a reduction of their amount in the cells.	Heparitin Sulfate	78-93	FAM20B glycosaminoglycan xylosylkinase	Homo sapiens	18-24
19481194-0	2009	Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia.	Heparitin Sulfate	17-32	glypican 6	Homo sapiens	46-56
19481194-0	2009	Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia.	Heparitin Sulfate	17-32	glypican 6	Homo sapiens	58-62
19110070-4	2009	Here, treatment with FGF-2 strongly reduces the expression levels of the heparan sulfate-containing proteoglycan, syndecan-4.	Heparitin Sulfate	73-88	fibroblast growth factor 2	Homo sapiens	21-26
19110070-4	2009	Here, treatment with FGF-2 strongly reduces the expression levels of the heparan sulfate-containing proteoglycan, syndecan-4.	Heparitin Sulfate	73-88	syndecan 4	Homo sapiens	114-124
19336402-1	2009	HSEPI (glucuronyl C5-epimerase) catalyzes the conversion of d-glucuronic acid to l-iduronic acid in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	100-115	glucuronyl C5-epimerase	Mus musculus	0-5
19336402-1	2009	HSEPI (glucuronyl C5-epimerase) catalyzes the conversion of d-glucuronic acid to l-iduronic acid in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	100-115	glucuronyl C5-epimerase	Mus musculus	7-30
19336402-1	2009	HSEPI (glucuronyl C5-epimerase) catalyzes the conversion of d-glucuronic acid to l-iduronic acid in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	0-2	glucuronyl C5-epimerase	Mus musculus	7-30
19254961-0	2009	Specific inhibition of FGF-2 signaling with 2-O-sulfated octasaccharides of heparan sulfate.	Heparitin Sulfate	76-91	fibroblast growth factor 2	Cricetulus griseus	23-28
19254961-1	2009	In fibroblast growth factor (FGF)-2 signaling, the formation of a ternary complex of FGF-2, tyrosine-kinase fibroblast growth factor receptor (FGFR)-1, and cell surface heparan sulfate (HS) proteoglycan is known to be critical for the activation of FGFR-1 and downstream signal transduction.	Heparitin Sulfate	169-184	fibroblast growth factor 2	Cricetulus griseus	3-35
19254961-1	2009	In fibroblast growth factor (FGF)-2 signaling, the formation of a ternary complex of FGF-2, tyrosine-kinase fibroblast growth factor receptor (FGFR)-1, and cell surface heparan sulfate (HS) proteoglycan is known to be critical for the activation of FGFR-1 and downstream signal transduction.	Heparitin Sulfate	169-184	fibroblast growth factor receptor 1	Cricetulus griseus	249-255
19254961-6	2009	In CHO-677 cells deficient in HS biosynthesis, heparin enhanced FGF-2-induced phosphorylation of ERK1/2.	Heparitin Sulfate	30-32	fibroblast growth factor 2	Cricetulus griseus	64-69
19422911-8	2009	In support of this hypothesis we demonstrated that human perlecan bound in a heparan sulfate-dependent fashion to VEGF-A(165).	Heparitin Sulfate	77-92	vascular endothelial growth factor A	Homo sapiens	114-120
19414521-6	2009	In surface plasmon resonance experiments using immobilized heparan sulfate (HS) and physiological buffer conditions, Met-RANTES exhibited a significantly longer residual time on the GAG chip compared with the other RANTES variants.	Heparitin Sulfate	59-74	C-C motif chemokine ligand 5	Rattus norvegicus	121-127
19414521-6	2009	In surface plasmon resonance experiments using immobilized heparan sulfate (HS) and physiological buffer conditions, Met-RANTES exhibited a significantly longer residual time on the GAG chip compared with the other RANTES variants.	Heparitin Sulfate	76-78	C-C motif chemokine ligand 5	Rattus norvegicus	121-127
19416848-2	2009	The primary cause is mutation in the NAGLU gene, resulting in deficiency of alpha-N-acetylglucosaminidase and lysosomal accumulation of heparan sulfate.	Heparitin Sulfate	136-151	N-acetyl-alpha-glucosaminidase	Homo sapiens	37-42
19466598-5	2009	This review will focus on the functional roles of the major heparan sulfate proteoglycans from basement membrane zones: perlecan, agrin and collagen XVIII, and on their roles in modulating cancer growth and angiogenesis.	Heparitin Sulfate	60-75	agrin	Homo sapiens	130-135
19466598-5	2009	This review will focus on the functional roles of the major heparan sulfate proteoglycans from basement membrane zones: perlecan, agrin and collagen XVIII, and on their roles in modulating cancer growth and angiogenesis.	Heparitin Sulfate	60-75	collagen type XVIII alpha 1 chain	Homo sapiens	140-154
19298595-2	2009	As heparan sulphate and chondroitin sulphate are the bioactive components of syndecan-1, we analysed the signature of genes encoding 100 proteins involved in synthesis of these chains, i.e. from precursor uptake to post-translational modifications, using Affymetrix microarrays.	Heparitin Sulfate	3-19	syndecan 1	Homo sapiens	77-87
19298595-3	2009	The expression of enzymes required for heparan sulphate and chondroitin sulphate biosynthesis was shown to increase in parallel with syndecan-1 expression, throughout the differentiation of memory B cells into plasmablasts and normal bone marrow plasma cells.	Heparitin Sulfate	39-55	syndecan 1	Homo sapiens	133-143
19569526-6	2009	We propose that Ingramon might interfere with MCP-1-heparin/heparan sulphate binding on cell surface.	Heparitin Sulfate	60-76	C-C motif chemokine ligand 2	Homo sapiens	46-51
19259985-1	2009	Heparan sulfate proteoglycans cooperate with basic fibroblast growth factor (bFGF/FGF2) signaling to control osteoblast growth and differentiation, as well as metabolic functions of osteoblasts.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	77-81
19259985-1	2009	Heparan sulfate proteoglycans cooperate with basic fibroblast growth factor (bFGF/FGF2) signaling to control osteoblast growth and differentiation, as well as metabolic functions of osteoblasts.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	82-86
19259985-5	2009	Runx2 increases expression of the glycosyltransferase Exostosin-1 (Ext1) and heparanase, as well as alters the relative expression of N-linked sulfotransferases (Ndst1 = Ndst2 &gt; Ndst3) and enzymes mediating O-linked sulfation of heparan sulfate (Hs2st &gt; Hs6st) or chondroitin sulfate (Cs4st &gt; Cs6st).	Heparitin Sulfate	232-247	RUNX family transcription factor 2	Homo sapiens	0-5
19259985-5	2009	Runx2 increases expression of the glycosyltransferase Exostosin-1 (Ext1) and heparanase, as well as alters the relative expression of N-linked sulfotransferases (Ndst1 = Ndst2 &gt; Ndst3) and enzymes mediating O-linked sulfation of heparan sulfate (Hs2st &gt; Hs6st) or chondroitin sulfate (Cs4st &gt; Cs6st).	Heparitin Sulfate	232-247	N-deacetylase and N-sulfotransferase 1	Homo sapiens	162-167
19264603-3	2009	Glycoprotein L (gL) plays a central role in MuHV-4 entry: it allows gH to bind heparan sulfate and regulates fusion-associated conformation changes in gH and gB.	Heparitin Sulfate	79-94	glycoprotein L	Murid gammaherpesvirus 4	0-14
19264603-3	2009	Glycoprotein L (gL) plays a central role in MuHV-4 entry: it allows gH to bind heparan sulfate and regulates fusion-associated conformation changes in gH and gB.	Heparitin Sulfate	79-94	glycoprotein L	Murid gammaherpesvirus 4	16-18
19264603-4	2009	However, gL is non-essential: heparan sulfate binding can also occur via gp70, and the gB-gH complex alone seems to be sufficient for membrane fusion.	Heparitin Sulfate	30-45	embigin	Homo sapiens	73-77
19264603-6	2009	Immune sera neutralized gL(-) virions more readily than gL(+) virions, chiefly because heparan sulfate binding now depended on gp70 and was therefore easier to block.	Heparitin Sulfate	87-102	embigin	Homo sapiens	127-131
19185514-1	2009	The presence of 3-O-sulfated glucosamine residues in heparin or heparan sulfate plays a role in binding to antithrombin III and HSV infection.	Heparitin Sulfate	64-79	serpin family C member 1	Homo sapiens	107-123
19299468-0	2009	NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development.	Heparitin Sulfate	16-31	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	0-5
19299468-2	2009	N-deacetylase/N-sulfotransferase-1 (NDST1) participates in synthesizing heparan sulfate (HS) chains of HSPGs, and is involved in bone and lung development.	Heparitin Sulfate	72-87	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	0-34
19299468-2	2009	N-deacetylase/N-sulfotransferase-1 (NDST1) participates in synthesizing heparan sulfate (HS) chains of HSPGs, and is involved in bone and lung development.	Heparitin Sulfate	72-87	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	36-41
19299468-2	2009	N-deacetylase/N-sulfotransferase-1 (NDST1) participates in synthesizing heparan sulfate (HS) chains of HSPGs, and is involved in bone and lung development.	Heparitin Sulfate	89-91	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	0-34
19299468-2	2009	N-deacetylase/N-sulfotransferase-1 (NDST1) participates in synthesizing heparan sulfate (HS) chains of HSPGs, and is involved in bone and lung development.	Heparitin Sulfate	89-91	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	36-41
19371605-5	2009	Specifically, the transmembrane heparan sulfate proteoglycan, syndecan-1, is found to mediate the initial interactions of the particles at the cell surface, their coupling with actin filaments across the cell membrane, and their subsequent internalization via macropinocytosis.	Heparitin Sulfate	32-47	syndecan 1	Homo sapiens	62-72
19150438-2	2009	Many alternatively-spliced forms of the NRG1 gene are released as soluble factors that can diffuse to near and distant sites within the nervous system where they can accumulate through binding to highly specific heparan-sulfate proteoglycans in the extracellular matrix.	Heparitin Sulfate	212-227	neuregulin 1	Homo sapiens	40-44
19291294-7	2009	We also found overexpression of at least one proteoglycan with heparan sulfate chains (HS), which are coreceptors for APRIL and TACI, in tumors where APRIL is either overexpressed or is a prognostic factor.	Heparitin Sulfate	63-78	TNF receptor superfamily member 13B	Homo sapiens	118-132
19131102-3	2009	Sulfated polysaccharides, such as native heparin, and heparan sulfate have been found to modulate BMP-2 bioactivity and play pivotal roles in bone metabolism.	Heparitin Sulfate	54-69	bone morphogenetic protein 2	Mus musculus	98-103
19285275-1	2009	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulphate (HS) side chains of heparan sulphate proteoglycans on cell surfaces and the extracellular matrix; activity that is strongly implicated in tumour metastasis and angiogenesis.	Heparitin Sulfate	63-79	glucuronidase beta	Homo sapiens	22-42
19285275-1	2009	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulphate (HS) side chains of heparan sulphate proteoglycans on cell surfaces and the extracellular matrix; activity that is strongly implicated in tumour metastasis and angiogenesis.	Heparitin Sulfate	81-83	glucuronidase beta	Homo sapiens	22-42
19176481-0	2009	Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells.	Heparitin Sulfate	0-15	sonic hedgehog signaling molecule	Homo sapiens	52-66
19320882-3	2009	The ECM can directly bind to and release certain growth factors (e.g., heparan sulfate binding to fibroblast growth factor-2), which may serve to sequester and protect growth factors from degradation, and/or enhance their activity.	Heparitin Sulfate	71-86	fibroblast growth factor 2	Homo sapiens	98-124
19244131-1	2009	Heparanase is an endo-beta-d-glucuronidase capable of cleaving heparan sulfate, activity that is strongly implicated in cellular invasion associated with tumor metastasis, angiogenesis, and inflammation.	Heparitin Sulfate	63-78	glucuronidase beta	Homo sapiens	22-42
19302155-2	2009	Absent or greatly reduced activity of sulphamidase, a lysosomal protein, results in intracellular accumulation of heparan sulphate.	Heparitin Sulfate	114-130	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	38-50
19073595-0	2009	The heparan sulfate proteoglycan form of epithelial CD44v3 serves as a CD11b/CD18 counter-receptor during polymorphonuclear leukocyte transepithelial migration.	Heparitin Sulfate	4-19	integrin subunit alpha M	Homo sapiens	71-76
19096032-2	2009	Heparanase is the major enzyme capable of degrading heparan sulfate in mammalian cells.	Heparitin Sulfate	52-67	heparanase	Homo sapiens	0-10
19073595-0	2009	The heparan sulfate proteoglycan form of epithelial CD44v3 serves as a CD11b/CD18 counter-receptor during polymorphonuclear leukocyte transepithelial migration.	Heparitin Sulfate	4-19	lymphotoxin beta receptor	Homo sapiens	77-81
19073595-6	2009	Further studies demonstrated that this epithelial CD44v3 specifically binds to CD11b/CD18 through its heparan sulfate moieties.	Heparitin Sulfate	102-117	integrin subunit alpha M	Homo sapiens	79-84
19073595-6	2009	Further studies demonstrated that this epithelial CD44v3 specifically binds to CD11b/CD18 through its heparan sulfate moieties.	Heparitin Sulfate	102-117	lymphotoxin beta receptor	Homo sapiens	85-89
19073595-7	2009	In summary, our study demonstrates for the first time that the heparan sulfate proteoglycan form of epithelial CD44v3 plays a critical role in facilitating PMN recruitment during inflammatory episodes via directly binding to CD11b/CD18.	Heparitin Sulfate	63-78	integrin subunit alpha M	Homo sapiens	225-230
19073595-7	2009	In summary, our study demonstrates for the first time that the heparan sulfate proteoglycan form of epithelial CD44v3 plays a critical role in facilitating PMN recruitment during inflammatory episodes via directly binding to CD11b/CD18.	Heparitin Sulfate	63-78	lymphotoxin beta receptor	Homo sapiens	231-235
18190591-1	2009	Syndecan-1 (sCD138) is a transmembrane heparan sulfate-bearing proteoglycan expressed in epithelial cells as well as hematopoietic cells that demonstrate plasmacytoid differentiation.	Heparitin Sulfate	39-54	syndecan 1	Homo sapiens	0-18
19144724-1	2009	Syndecan-4 (Syn4) is a heparan sulphate proteoglycan that is able to bind to some growth factors, including FGF, and can control cell migration.	Heparitin Sulfate	23-39	syndecan 4 S homeolog	Xenopus laevis	0-10
19144724-1	2009	Syndecan-4 (Syn4) is a heparan sulphate proteoglycan that is able to bind to some growth factors, including FGF, and can control cell migration.	Heparitin Sulfate	23-39	syndecan 4 S homeolog	Xenopus laevis	12-16
19109427-7	2009	Fibroblast response to fibulin-1, similar to tenascin-C, was dependent on expression of the heparan sulfate proteoglycan syndecan-4, which also binds to the HepII domain.	Heparitin Sulfate	92-107	fibulin 1	Homo sapiens	23-32
19115257-0	2009	Cell surface heparan sulfate released by heparanase promotes melanoma cell migration and angiogenesis.	Heparitin Sulfate	13-28	heparanase	Homo sapiens	41-51
19115257-2	2009	Heparanase (HPSE) is the only mammalian endoglycosidase known that cleaves HS, thus contributing to matrix degradation and cell invasion.	Heparitin Sulfate	75-77	heparanase	Homo sapiens	0-10
19115257-2	2009	Heparanase (HPSE) is the only mammalian endoglycosidase known that cleaves HS, thus contributing to matrix degradation and cell invasion.	Heparitin Sulfate	75-77	heparanase	Homo sapiens	12-16
19115257-3	2009	The enzyme acts as an endo-beta-D-glucuronidase resulting in HS fragments of discrete molecular weight size.	Heparitin Sulfate	61-63	glucuronidase beta	Homo sapiens	27-47
19115257-5	2009	We hypothesized that HPSE contributes to melanoma metastasis by generating bioactive HS from the cell-surface to facilitate biological activities of tumor cells as well as tumor microenvironment.	Heparitin Sulfate	85-87	heparanase	Homo sapiens	21-25
19196184-0	2009	Natural cytotoxicity receptors NKp30, NKp44 and NKp46 bind to different heparan sulfate/heparin sequences.	Heparitin Sulfate	72-87	natural cytotoxicity triggering receptor 3	Homo sapiens	31-36
19196184-0	2009	Natural cytotoxicity receptors NKp30, NKp44 and NKp46 bind to different heparan sulfate/heparin sequences.	Heparitin Sulfate	72-87	natural cytotoxicity triggering receptor 2	Homo sapiens	38-43
19196184-0	2009	Natural cytotoxicity receptors NKp30, NKp44 and NKp46 bind to different heparan sulfate/heparin sequences.	Heparitin Sulfate	72-87	natural cytotoxicity triggering receptor 1	Homo sapiens	48-53
19196184-5	2009	This study aims to elucidate heparan sulfate structural motifs that are important for NCR binding.	Heparitin Sulfate	29-44	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	86-89
19109427-7	2009	Fibroblast response to fibulin-1, similar to tenascin-C, was dependent on expression of the heparan sulfate proteoglycan syndecan-4, which also binds to the HepII domain.	Heparitin Sulfate	92-107	syndecan 4	Homo sapiens	121-131
19171023-0	2009	Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor.	Heparitin Sulfate	24-39	ADAM metallopeptidase domain 17	Homo sapiens	50-54
19066875-3	2009	This study represents the effects of heparan sulfate (HSPG2) gene polymorphism for determining the risk of urolithiasis.	Heparitin Sulfate	37-52	heparan sulfate proteoglycan 2	Homo sapiens	54-59
19171023-0	2009	Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor.	Heparitin Sulfate	24-39	erb-b2 receptor tyrosine kinase 4	Homo sapiens	80-85
19171023-3	2009	Interactions between matrix metalloproteases and heparan sulfate have been described, but the effect of cell surface heparan sulfate on TACE activity has not been previously described.	Heparitin Sulfate	117-132	ADAM metallopeptidase domain 17	Homo sapiens	136-140
19171023-4	2009	RESULTS: As indicated by immunodetection of increased ErbB4 intracellular domain formation and direct enzyme activity analysis, TACE activity was substantially amplified by enzymatic removal of cell surface heparan sulfate but not chondroitin sulfate.	Heparitin Sulfate	207-222	ADAM metallopeptidase domain 17	Homo sapiens	128-132
19171023-6	2009	Removal of cell surface heparan sulfate led to increased formation of ErbB4 intracellular domain.	Heparitin Sulfate	24-39	erb-b2 receptor tyrosine kinase 4	Homo sapiens	70-75
18534197-2	2009	In particular, bovine lactoferrin (bLf) has been found to prevent viral infection by binding to heparan sulphate (HS) glycosaminoglycans (GAGs) that in turn can act as cell receptors for human herpetic viruses.	Heparitin Sulfate	96-112	lactotransferrin	Bos taurus	22-33
19567219-1	2009	Heparanase (HPSE) is an endoglycosidase that specifically degrades heparan sulfate, which is an abundant glycosaminoglycan of the pig placenta.	Heparitin Sulfate	67-82	heparanase	Sus scrofa	0-10
19469644-2	2009	It is known that heparanase-1 (HPA-1) plays an important role in cleaving heparan sulfate.	Heparitin Sulfate	74-89	heparanase	Homo sapiens	17-29
19469644-2	2009	It is known that heparanase-1 (HPA-1) plays an important role in cleaving heparan sulfate.	Heparitin Sulfate	74-89	heparanase	Homo sapiens	31-36
19305494-1	2009	Syndecan-1 is a transmembrane heparan sulfate-bearing proteoglycan known to regulate multiple biological functions at the cell surface and within the extracellular matrix.	Heparitin Sulfate	30-45	syndecan 1	Homo sapiens	0-10
19650410-1	2009	It is an autosomal recessive lysosomal disorder caused by a deficiency of the N-acetylglucosamine-6-sulphatase (GlcNAc-6S sulphatase, GNS), a hydrolase, which is one of the enzymes involved in heparan sulfate catabolism leading to lysosomal storage.	Heparitin Sulfate	193-208	glucosamine (N-acetyl)-6-sulfatase	Homo sapiens	134-137
19567219-1	2009	Heparanase (HPSE) is an endoglycosidase that specifically degrades heparan sulfate, which is an abundant glycosaminoglycan of the pig placenta.	Heparitin Sulfate	67-82	heparanase	Sus scrofa	12-16
18980226-1	2008	HIP/RPL29 is a heparan sulfate (HS) binding protein with diverse activities including modulation of heparanase (HPSE) activity.	Heparitin Sulfate	15-30	ribosomal protein L29	Homo sapiens	4-9
19035835-8	2008	These findings contribute to delineating the mechanism by which heparin or heparan sulfate mediates antiangiogenic activity of antithrombin.	Heparitin Sulfate	75-90	serpin family C member 1	Homo sapiens	127-139
19082421-1	2008	The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice.	Heparitin Sulfate	4-19	glypican 1	Mus musculus	34-44
19082421-1	2008	The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice.	Heparitin Sulfate	4-19	glypican 1	Mus musculus	46-50
18796646-2	2008	Heparan sulfate on the cell surface binds SDF-1 and may modulate its function as a coreceptor of this chemokine.	Heparitin Sulfate	0-15	C-X-C motif chemokine ligand 12	Homo sapiens	42-47
18798279-1	2008	Heparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains, a class of glycosaminoglycans abundantly present in the extracellular matrix and on the cell surface.	Heparitin Sulfate	59-74	heparanase	Homo sapiens	0-10
18980226-1	2008	HIP/RPL29 is a heparan sulfate (HS) binding protein with diverse activities including modulation of heparanase (HPSE) activity.	Heparitin Sulfate	15-30	heparanase	Homo sapiens	100-110
18980226-1	2008	HIP/RPL29 is a heparan sulfate (HS) binding protein with diverse activities including modulation of heparanase (HPSE) activity.	Heparitin Sulfate	15-30	heparanase	Homo sapiens	112-116
18980226-1	2008	HIP/RPL29 is a heparan sulfate (HS) binding protein with diverse activities including modulation of heparanase (HPSE) activity.	Heparitin Sulfate	32-34	ribosomal protein L29	Homo sapiens	4-9
18980226-1	2008	HIP/RPL29 is a heparan sulfate (HS) binding protein with diverse activities including modulation of heparanase (HPSE) activity.	Heparitin Sulfate	32-34	heparanase	Homo sapiens	100-110
18980226-1	2008	HIP/RPL29 is a heparan sulfate (HS) binding protein with diverse activities including modulation of heparanase (HPSE) activity.	Heparitin Sulfate	32-34	heparanase	Homo sapiens	112-116
18980226-11	2008	At pH 5.0, release of soluble HS was inhibited by 64% at concentrations of 5 microg/ml and by 77% at 40 microg/ml, indicating that HIP/RPL29 antagonizes HPSE activity.	Heparitin Sulfate	30-32	ribosomal protein L29	Homo sapiens	135-140
18980226-11	2008	At pH 5.0, release of soluble HS was inhibited by 64% at concentrations of 5 microg/ml and by 77% at 40 microg/ml, indicating that HIP/RPL29 antagonizes HPSE activity.	Heparitin Sulfate	30-32	heparanase	Homo sapiens	153-157
18801731-0	2008	Heparan sulfate regulates ADAM12 through a molecular switch mechanism.	Heparitin Sulfate	0-15	ADAM metallopeptidase domain 12	Homo sapiens	26-32
18842719-10	2008	Nevertheless, the interaction of A26 and A27 may have functional significance, since each is thought to mediate binding to cells through interaction with laminin and heparan sulfate, respectively.	Heparitin Sulfate	166-181	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	33-36
18842719-10	2008	Nevertheless, the interaction of A26 and A27 may have functional significance, since each is thought to mediate binding to cells through interaction with laminin and heparan sulfate, respectively.	Heparitin Sulfate	166-181	immunoglobulin kappa variable 3-20	Homo sapiens	41-44
18801731-3	2008	Here ADAM12, a protease that promotes tumor progression and chondrocyte proliferation in osteoarthritic cartilage, is shown to possess a prodomain/catalytic domain cationic molecular switch, regulated by exogenous heparan sulfate and heparin but also endogenous cell surface proteoglycans and the polyanion, calcium pentosan polysulfate.	Heparitin Sulfate	214-229	ADAM metallopeptidase domain 12	Homo sapiens	5-11
18801731-5	2008	Moreover, human heparanase, an enzyme also linked to tumorigenesis, can promote ADAM12 sheddase activity at the cell surface through cleavage of the inhibitory heparan sulfate.	Heparitin Sulfate	160-175	ADAM metallopeptidase domain 12	Homo sapiens	80-86
18664627-2	2008	VEGF isoforms differ in ability to bind coreceptors heparan sulfate (HS) and neuropilin-1 (NRP1).	Heparitin Sulfate	52-67	vascular endothelial growth factor Aa	Danio rerio	0-4
18703790-1	2008	RATIONALE: Superoxide dismutase (SOD) 3 inhibits oxidative fragmentation of lung matrix components collagen I, hyaluronan, and heparan sulfate.	Heparitin Sulfate	127-142	superoxide dismutase 1	Homo sapiens	11-31
18703790-1	2008	RATIONALE: Superoxide dismutase (SOD) 3 inhibits oxidative fragmentation of lung matrix components collagen I, hyaluronan, and heparan sulfate.	Heparitin Sulfate	127-142	superoxide dismutase 1	Homo sapiens	33-36
18653544-9	2008	Ado enhanced MMP-9 production when macrophages were activated by hypoxia or Toll-like receptor-4 ligands such as lipopolysaccharide, hyaluronan, and heparan sulfate.	Heparitin Sulfate	149-164	matrix metallopeptidase 9	Homo sapiens	13-18
18664627-2	2008	VEGF isoforms differ in ability to bind coreceptors heparan sulfate (HS) and neuropilin-1 (NRP1).	Heparitin Sulfate	69-71	vascular endothelial growth factor Aa	Danio rerio	0-4
19049640-7	2008	These results indicate that mucosal antibodies inhibiting binding of VLP to heparan sulfate are developed in most LSIL patients, but are hardly present in cervical cancer patients.	Heparitin Sulfate	76-91	VHL like	Homo sapiens	69-72
18753130-1	2008	The syndecan proteoglycans are an ancient class of receptor, bearing heparan sulfate chains that interact with numerous potential ligands including growth factors, morphogens, and extracellular matrix molecules.	Heparitin Sulfate	69-84	syndecan 1	Homo sapiens	4-12
18761723-0	2008	Heparan sulfates from arteries and veins differ in their antithrombin-mediated anticoagulant activity.	Heparitin Sulfate	0-16	serpin family C member 1	Homo sapiens	57-69
18669628-8	2008	Heparan sulfate chains were fractionated according to their affinity for antithrombin, and their structure was analyzed by 1H NMR and MS/MS.	Heparitin Sulfate	0-15	serpin family C member 1	Homo sapiens	73-85
18469308-3	2008	Endothelial heparan sulfate proteoglycans (HSPG), and heparan sulfate in particular, play an important role in the inflammatory process by acting as a ligand for l-selectin.	Heparitin Sulfate	12-27	selectin L	Homo sapiens	162-172
18518922-2	2008	Reduced activity of sulphamidase (SGSH; EC 3.10.1.1) results in intracellular accumulation of heparan sulphate (HS), with the brain the primary site of pathology.	Heparitin Sulfate	94-110	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	20-32
18518922-2	2008	Reduced activity of sulphamidase (SGSH; EC 3.10.1.1) results in intracellular accumulation of heparan sulphate (HS), with the brain the primary site of pathology.	Heparitin Sulfate	94-110	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	34-38
18518922-2	2008	Reduced activity of sulphamidase (SGSH; EC 3.10.1.1) results in intracellular accumulation of heparan sulphate (HS), with the brain the primary site of pathology.	Heparitin Sulfate	112-114	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	20-32
18518922-2	2008	Reduced activity of sulphamidase (SGSH; EC 3.10.1.1) results in intracellular accumulation of heparan sulphate (HS), with the brain the primary site of pathology.	Heparitin Sulfate	112-114	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	34-38
18459126-4	2008	Moreover, our data suggested that PGF2alpha could induce new synthesis of heparan sulphate (HS) chains on osteoblasts by a mechanism involving a modulation of MAPK signalling and that HS is required for the regulation of FGF-2 induced by PGF2alpha.	Heparitin Sulfate	92-94	fibroblast growth factor 2	Homo sapiens	221-226
18669635-0	2008	Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions.	Heparitin Sulfate	0-15	fibrillin 1	Homo sapiens	26-37
18669635-7	2008	Thus, fibrillin-1 N-terminal interactions with heparin/heparan sulfate directly influence cell behavior, whereas C-terminal interactions with heparin/heparan sulfate regulate elastin deposition.	Heparitin Sulfate	55-70	fibrillin 1	Homo sapiens	6-17
18669635-8	2008	These data highlight how heparin/heparan sulfate controls fibrillin-1 interactions.	Heparitin Sulfate	33-48	fibrillin 1	Homo sapiens	58-69
18765417-4	2008	A continuous 2-week delivery of DNAXTas near the rostral border of a peripheral nerve graft bridging the transected dorsal columns in the thoracic spinal cord resulted in an 81% decrease in XT-1 mRNA, an average of 1.4-fold reduction in GAG-side chains of chondroitin sulphate or heparan sulphate-PGs and 2.2-fold reduction in neurocan and brevican core proteins in scar tissue.	Heparitin Sulfate	280-296	xylosyltransferase 1	Rattus norvegicus	190-194
18469308-3	2008	Endothelial heparan sulfate proteoglycans (HSPG), and heparan sulfate in particular, play an important role in the inflammatory process by acting as a ligand for l-selectin.	Heparitin Sulfate	12-27	syndecan 2	Homo sapiens	43-47
18640695-0	2008	Bovine lactoferrin inhibits Japanese encephalitis virus by binding to heparan sulfate and receptor for low density lipoprotein.	Heparitin Sulfate	70-85	lactotransferrin	Bos taurus	7-18
18640695-2	2008	Binding of lactoferrin to cell surface expressed heparan sulfate (HS), one possible receptor for JEV, has been postulated to be the possible mechanism of anti-JEV antiviral activity.	Heparitin Sulfate	49-64	lactotransferrin	Bos taurus	11-22
18640695-2	2008	Binding of lactoferrin to cell surface expressed heparan sulfate (HS), one possible receptor for JEV, has been postulated to be the possible mechanism of anti-JEV antiviral activity.	Heparitin Sulfate	66-68	lactotransferrin	Bos taurus	11-22
18725627-5	2008	Addition of surfen to cultured cells blocked FGF2-binding and signaling that depended on cell surface heparan sulfate and prevented both FGF2- and VEGF(165)-mediated sprouting of endothelial cells in Matrigel.	Heparitin Sulfate	102-117	fibroblast growth factor 2	Homo sapiens	45-49
18662687-1	2008	Heparanase is an endo-beta-D-glucuronidase responsible for the cleavage of heparan sulfate, participating in extracellular matrix degradation and remodeling.	Heparitin Sulfate	75-90	glucuronidase beta	Homo sapiens	22-42
18456345-2	2008	The anti-HSV mode of action of Lf and Lfcin is assumed to involve, in part, their interaction with the cell surface glycosaminoglycan heparan sulfate, thereby blocking of viral entry.	Heparitin Sulfate	134-149	lactotransferrin	Homo sapiens	38-43
18543267-0	2008	EXTL3 promoter methylation down-regulates EXTL3 and heparan sulphate expression in mucinous colorectal cancers.	Heparitin Sulfate	52-68	exostosin like glycosyltransferase 3	Homo sapiens	0-5
18618498-1	2008	BACKGROUND: Heparanase is an endo-beta-D-glucuronidase that is capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, yielding HS fragments of still appreciable size (approximately 5-7 kDa).	Heparitin Sulfate	83-98	heparanase	Homo sapiens	12-22
18618498-1	2008	BACKGROUND: Heparanase is an endo-beta-D-glucuronidase that is capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, yielding HS fragments of still appreciable size (approximately 5-7 kDa).	Heparitin Sulfate	83-98	glucuronidase beta	Homo sapiens	34-54
18618498-1	2008	BACKGROUND: Heparanase is an endo-beta-D-glucuronidase that is capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, yielding HS fragments of still appreciable size (approximately 5-7 kDa).	Heparitin Sulfate	100-102	heparanase	Homo sapiens	12-22
18618498-1	2008	BACKGROUND: Heparanase is an endo-beta-D-glucuronidase that is capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, yielding HS fragments of still appreciable size (approximately 5-7 kDa).	Heparitin Sulfate	100-102	glucuronidase beta	Homo sapiens	34-54
18618498-1	2008	BACKGROUND: Heparanase is an endo-beta-D-glucuronidase that is capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, yielding HS fragments of still appreciable size (approximately 5-7 kDa).	Heparitin Sulfate	155-157	heparanase	Homo sapiens	12-22
18618498-1	2008	BACKGROUND: Heparanase is an endo-beta-D-glucuronidase that is capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, yielding HS fragments of still appreciable size (approximately 5-7 kDa).	Heparitin Sulfate	155-157	glucuronidase beta	Homo sapiens	34-54
18717736-1	2008	The copper-binding cellular prion protein (PrP(C)) and the heparan sulphate (HS)-containing proteoglycan glypican-1 (Gpc-1) can both be attached to lipid rafts via their glycosylphosphatidylinositol anchors, and copper ions stimulate their cointernalization from the cell surface to endosomes.	Heparitin Sulfate	59-75	glypican 1	Mus musculus	117-122
18717736-1	2008	The copper-binding cellular prion protein (PrP(C)) and the heparan sulphate (HS)-containing proteoglycan glypican-1 (Gpc-1) can both be attached to lipid rafts via their glycosylphosphatidylinositol anchors, and copper ions stimulate their cointernalization from the cell surface to endosomes.	Heparitin Sulfate	77-79	glypican 1	Mus musculus	117-122
18713994-5	2008	Further, we demonstrate that the positively charged residues of the lambda5 unique tail, which are required for pre-BCR self-oligomerization, can also mediate binding to stroma cell-associated self-Ags, such as heparan sulfate.	Heparitin Sulfate	211-226	immunoglobulin lambda-like polypeptide 1	Mus musculus	68-75
18691882-0	2008	VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.	Heparitin Sulfate	31-47	vascular endothelial growth factor A	Homo sapiens	0-4
18691882-0	2008	VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.	Heparitin Sulfate	31-47	matrix metallopeptidase 9	Homo sapiens	16-21
18691882-7	2008	MMP-9 treated spheroids showed decreased extracellular levels of heparan sulphates, required for VEGF binding to the matrix, whereas the levels in the medium were increased.	Heparitin Sulfate	65-82	matrix metallopeptidase 9	Homo sapiens	0-5
18691882-7	2008	MMP-9 treated spheroids showed decreased extracellular levels of heparan sulphates, required for VEGF binding to the matrix, whereas the levels in the medium were increased.	Heparitin Sulfate	65-82	vascular endothelial growth factor A	Homo sapiens	97-101
18691882-13	2008	In conclusion, we have shown that neutrophil-derived MMP-9 is able to release biologically active VEGF(165) from the ECM of colon cancer cells by the cleavage of heparan sulphates.	Heparitin Sulfate	162-179	matrix metallopeptidase 9	Homo sapiens	53-58
18691882-13	2008	In conclusion, we have shown that neutrophil-derived MMP-9 is able to release biologically active VEGF(165) from the ECM of colon cancer cells by the cleavage of heparan sulphates.	Heparitin Sulfate	162-179	vascular endothelial growth factor A	Homo sapiens	98-102
18766266-0	2008	Heparan sulfate proteoglycan is essential to thrombin-induced calcium transients and nitric oxide production in aortic endothelial cells.	Heparitin Sulfate	0-15	coagulation factor II, thrombin	Bos taurus	45-53
18562532-5	2008	This recombinant virus has a weaker affinity for heparan sulfate, resulting in an increased serum half-life, higher systemic viral loads, and high levels of TNF-alpha in the serum of infected mice.	Heparitin Sulfate	49-64	tumor necrosis factor	Mus musculus	157-166
18602469-3	2008	Previous studies have suggested that cell-surface heparan sulfate proteoglycans like syndecan-4 are involved in fibroblast growth factor 2 (FGF2) signaling by FGF2 binding to the heparan sulfate chains.	Heparitin Sulfate	50-65	syndecan-4	Meleagris gallopavo	85-95
18602469-3	2008	Previous studies have suggested that cell-surface heparan sulfate proteoglycans like syndecan-4 are involved in fibroblast growth factor 2 (FGF2) signaling by FGF2 binding to the heparan sulfate chains.	Heparitin Sulfate	50-65	fibroblast growth factor 2	Meleagris gallopavo	112-138
18602469-3	2008	Previous studies have suggested that cell-surface heparan sulfate proteoglycans like syndecan-4 are involved in fibroblast growth factor 2 (FGF2) signaling by FGF2 binding to the heparan sulfate chains.	Heparitin Sulfate	50-65	fibroblast growth factor 2	Meleagris gallopavo	140-144
18602469-3	2008	Previous studies have suggested that cell-surface heparan sulfate proteoglycans like syndecan-4 are involved in fibroblast growth factor 2 (FGF2) signaling by FGF2 binding to the heparan sulfate chains.	Heparitin Sulfate	50-65	fibroblast growth factor 2	Meleagris gallopavo	159-163
19378419-11	2008	CONCLUSION: These results demonstrated that CTGF induces production of fractalkine, MCP-1 and RANTES via ERK1/2 and PI3-K/PKB/NF-kappaB-dependent signal pathway mediated by cell surface heparin sulfate proteoglycans and the tyrosine kinase receptor TrkA in human mesangial cells.	Heparitin Sulfate	186-201	cellular communication network factor 2	Homo sapiens	44-48
18695242-6	2008	Additionally, we observed loss of gPAPP leads to perturbations in the levels of heparan sulfate species in lung tissue and whole embryos.	Heparitin Sulfate	80-95	3'(2'), 5'-bisphosphate nucleotidase 2	Mus musculus	34-39
18715996-0	2008	Heparan sulfate regulates ephrin-A3/EphA receptor signaling.	Heparitin Sulfate	0-15	ephrin A3	Mus musculus	26-35
18715996-4	2008	Here, we show that ephrin-A3 binds to heparan sulfate, and that the presence of cell surface heparan sulfate is required for the full biological activity of ephrin-A3.	Heparitin Sulfate	38-53	ephrin A3	Mus musculus	19-28
18715996-4	2008	Here, we show that ephrin-A3 binds to heparan sulfate, and that the presence of cell surface heparan sulfate is required for the full biological activity of ephrin-A3.	Heparitin Sulfate	93-108	ephrin A3	Mus musculus	157-166
18715996-5	2008	Among the ephrins tested, including ephrin-A1, -A2, -A5, -B1, and -B2, only ephrin-A3 binds heparin or heparan sulfate.	Heparitin Sulfate	103-118	ephrin A3	Mus musculus	76-85
18715996-6	2008	Ephrin-A3-dependent EphA receptor activation is reduced in mutant cells that are defective in heparan sulfate synthesis, in wild-type cells from which cell surface heparan sulfate has been removed, and in the hippocampus of conditional knockout mice defective in heparan sulfate synthesis.	Heparitin Sulfate	94-109	ephrin A3	Mus musculus	0-9
18715996-6	2008	Ephrin-A3-dependent EphA receptor activation is reduced in mutant cells that are defective in heparan sulfate synthesis, in wild-type cells from which cell surface heparan sulfate has been removed, and in the hippocampus of conditional knockout mice defective in heparan sulfate synthesis.	Heparitin Sulfate	164-179	ephrin A3	Mus musculus	0-9
18715996-6	2008	Ephrin-A3-dependent EphA receptor activation is reduced in mutant cells that are defective in heparan sulfate synthesis, in wild-type cells from which cell surface heparan sulfate has been removed, and in the hippocampus of conditional knockout mice defective in heparan sulfate synthesis.	Heparitin Sulfate	164-179	ephrin A3	Mus musculus	0-9
18715996-7	2008	Ephrin-A3-dependent cell rounding is impaired in CHO cells lacking heparan sulfate, and cortical neurons lacking heparan sulfate exhibit impaired growth cone collapse.	Heparitin Sulfate	67-82	ephrin-A3	Cricetulus griseus	0-9
18715996-9	2008	These results show that heparan sulfate modulates ephrin/Eph signaling and suggest a physiological role for heparan sulfate proteoglycans in the regulation of ephrin-A3-dependent biological processes.	Heparitin Sulfate	24-39	ephrin A3	Mus musculus	159-168
18646256-1	2008	Heparanase, the enzyme that degrades heparan sulfate, has been implicated to play important and characteristic roles in organogenesis, tissue organization, cell migration, and tumor metastasis.	Heparitin Sulfate	37-52	heparanase	Homo sapiens	0-10
19378419-11	2008	CONCLUSION: These results demonstrated that CTGF induces production of fractalkine, MCP-1 and RANTES via ERK1/2 and PI3-K/PKB/NF-kappaB-dependent signal pathway mediated by cell surface heparin sulfate proteoglycans and the tyrosine kinase receptor TrkA in human mesangial cells.	Heparitin Sulfate	186-201	C-X3-C motif chemokine ligand 1	Homo sapiens	71-82
19378419-11	2008	CONCLUSION: These results demonstrated that CTGF induces production of fractalkine, MCP-1 and RANTES via ERK1/2 and PI3-K/PKB/NF-kappaB-dependent signal pathway mediated by cell surface heparin sulfate proteoglycans and the tyrosine kinase receptor TrkA in human mesangial cells.	Heparitin Sulfate	186-201	C-C motif chemokine ligand 5	Homo sapiens	94-100
18626493-3	2008	In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.	Heparitin Sulfate	58-73	exostosin glycosyltransferase 1	Homo sapiens	91-95
18503048-2	2008	In this study we examined the relationship between TGF-beta1 stimulation and the expression of heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) in cultured normal human lung fibroblasts (NHLFs) and in murine lungs in vivo.	Heparitin Sulfate	95-110	transforming growth factor beta 1	Homo sapiens	51-60
18499669-2	2008	We demonstrate that the compensatory effect of the TG-FN complex in the presence of RGD-containing peptides is mediated by TG2 binding to the heparan sulfate chains of the syndecan-4 cell surface receptor.	Heparitin Sulfate	142-157	syndecan 4	Homo sapiens	172-182
18647407-1	2008	Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix (ECM) and basement membrane.	Heparitin Sulfate	47-62	heparanase	Homo sapiens	0-10
18499671-2	2008	Here we evaluated the role of syndecan-1, a major heparan sulfate proteoglycan, in modulating inflammatory responses in Gram-positive toxic shock, a systemic disease that is a significant cause of morbidity and mortality.	Heparitin Sulfate	50-65	syndecan 1	Mus musculus	30-40
18499671-7	2008	Importantly, syndecan-1 shedding was induced in wild-type mice injected with staphylococcal enterotoxin B, and the administration of heparan sulfate, but not syndecan-1 core protein, rescued syndecan-1-null mice from lethal toxic shock by suppressing the production of TNFalpha and IL-6, and attenuating inflammatory tissue injury.	Heparitin Sulfate	133-148	syndecan 1	Mus musculus	13-23
18499671-7	2008	Importantly, syndecan-1 shedding was induced in wild-type mice injected with staphylococcal enterotoxin B, and the administration of heparan sulfate, but not syndecan-1 core protein, rescued syndecan-1-null mice from lethal toxic shock by suppressing the production of TNFalpha and IL-6, and attenuating inflammatory tissue injury.	Heparitin Sulfate	133-148	tumor necrosis factor	Mus musculus	269-277
18499671-7	2008	Importantly, syndecan-1 shedding was induced in wild-type mice injected with staphylococcal enterotoxin B, and the administration of heparan sulfate, but not syndecan-1 core protein, rescued syndecan-1-null mice from lethal toxic shock by suppressing the production of TNFalpha and IL-6, and attenuating inflammatory tissue injury.	Heparitin Sulfate	133-148	interleukin 6	Mus musculus	282-286
18503048-2	2008	In this study we examined the relationship between TGF-beta1 stimulation and the expression of heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) in cultured normal human lung fibroblasts (NHLFs) and in murine lungs in vivo.	Heparitin Sulfate	95-110	sulfatase 1	Homo sapiens	137-142
18648536-3	2008	CXCL12gamma is formed by a protein core shared by all CXCL12 isoforms, extended by a highly cationic carboxy-terminal (C-ter) domain that encompass four overlapped BBXB heparan sulfate (HS)-binding motifs.	Heparitin Sulfate	186-188	C-X-C motif chemokine ligand 12	Homo sapiens	0-6
18359766-2	2008	Heparan sulfate (HS) proteoglycans serve as essential co-receptors in Slit-Robo signaling.	Heparitin Sulfate	0-15	roundabout 1	Drosophila melanogaster	75-79
18450756-1	2008	Heparanase is an endo-beta-d-glucuronidase that degrades heparan sulfate in the extracellular matrix and on the cell surface.	Heparitin Sulfate	57-72	glucuronidase beta	Homo sapiens	22-42
18385133-0	2008	Altered heparan sulfate structure in mice with deleted NDST3 gene function.	Heparitin Sulfate	8-23	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	Mus musculus	55-60
18385133-1	2008	We report the generation and analysis of mutant mice bearing a targeted disruption of the heparan sulfate (HS)-modifying enzyme GlcNAc N-deacetylase/N-sulfotransferase 3 (NDST3).	Heparitin Sulfate	90-105	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	Mus musculus	171-176
18385133-1	2008	We report the generation and analysis of mutant mice bearing a targeted disruption of the heparan sulfate (HS)-modifying enzyme GlcNAc N-deacetylase/N-sulfotransferase 3 (NDST3).	Heparitin Sulfate	107-109	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	Mus musculus	171-176
18385133-4	2008	In contrast, NDST1(-/-);NDST3(-/-) compound mutant embryos display developmental defects caused by severe HS undersulfation, demonstrating NDST3 contribution to HS synthesis in the absence of NDST1.	Heparitin Sulfate	106-108	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	13-18
18385133-4	2008	In contrast, NDST1(-/-);NDST3(-/-) compound mutant embryos display developmental defects caused by severe HS undersulfation, demonstrating NDST3 contribution to HS synthesis in the absence of NDST1.	Heparitin Sulfate	106-108	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	Mus musculus	24-29
18385133-6	2008	Taken together, we show that NDST3 function is not essential for development or adult homeostasis despite contributing to HS synthesis in a region-specific manner and that the loss of NDST3 function is compensated for by the other NDST isoforms to a varying degree.	Heparitin Sulfate	122-124	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	Mus musculus	29-34
18359766-2	2008	Heparan sulfate (HS) proteoglycans serve as essential co-receptors in Slit-Robo signaling.	Heparitin Sulfate	17-19	roundabout 1	Drosophila melanogaster	75-79
18705521-1	2008	OBJECTIVE: Developing mouse molar was used as a model for the study of Syndecan-1, a transmembrane heparan sulfate proteoglycans, in order to approach the possible mechanism and function of this macromolecule during tooth development.	Heparitin Sulfate	99-114	syndecan 1	Mus musculus	71-81
19707363-1	2008	Mucopolysaccharidosis type II (MPS II, Hunter syndrome) is a heterogeneous, progressive X-linked recessively inherited lysosomal storage disease that is caused by a deficiency of the enzyme iduronate-2-sulfatase, resulting in abnormal tissue accumulation of the glycosaminoglycans, dermatan sulfate and heparan sulfate.	Heparitin Sulfate	303-318	iduronate 2-sulfatase	Homo sapiens	190-211
18219588-2	2008	HRG ligands include Zn2+, tropomyosin, heparin and heparan sulphate, plasminogen, plasmin, fibrinogen, thrombospondin, IgG, FcgR, and complement.	Heparitin Sulfate	51-67	histidine rich glycoprotein	Homo sapiens	0-3
18327763-7	2008	The retinotectal topographic projection to the optic tectum is perturbed in agrin morphants in association with a marked loss of heparan sulfate expression in the retinotectal pathway, with this phenotype resembling retinotectal phenotypes observed in mutant zebrafish lacking enzymes for heparan sulfate synthesis.	Heparitin Sulfate	289-304	agrin	Danio rerio	76-81
18541909-0	2008	In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate.	Heparitin Sulfate	96-111	lactotransferrin	Rattus norvegicus	21-32
18541909-4	2008	Diffusion measurements in free solution, supported by confocal imaging and binding assays with cultured cells, were used to characterize the properties of a fluorescently labeled protein, lactoferrin (Lf), and its association with heparin and heparan sulfate in vitro.	Heparitin Sulfate	243-258	lactotransferrin	Rattus norvegicus	188-199
18541909-4	2008	Diffusion measurements in free solution, supported by confocal imaging and binding assays with cultured cells, were used to characterize the properties of a fluorescently labeled protein, lactoferrin (Lf), and its association with heparin and heparan sulfate in vitro.	Heparitin Sulfate	243-258	lactotransferrin	Rattus norvegicus	201-203
18541909-5	2008	In vivo diffusion measurements were then performed through an open cranial window over rat somatosensory cortex to measure effective diffusion coefficients (D*) under different conditions, revealing that D* for Lf was reduced approximately 60% by binding to heparan sulfate proteoglycans, a prominent component of the ECM and cell surfaces in brain.	Heparitin Sulfate	258-273	lactotransferrin	Rattus norvegicus	211-213
18541909-6	2008	Finally, we describe a method for quantifying heparan sulfate binding site density from data for Lf and the structurally similar protein transferrin, allowing us to predict a low micromolar concentration of these binding sites in neocortex, the first estimate in living tissue.	Heparitin Sulfate	46-61	lactotransferrin	Rattus norvegicus	97-99
18541909-6	2008	Finally, we describe a method for quantifying heparan sulfate binding site density from data for Lf and the structurally similar protein transferrin, allowing us to predict a low micromolar concentration of these binding sites in neocortex, the first estimate in living tissue.	Heparitin Sulfate	46-61	transferrin	Rattus norvegicus	137-148
18425416-1	2008	Heparanase is an endoglycosidase that degrades heparan sulfate on the cell surface and extracellular matrix.	Heparitin Sulfate	47-62	heparanase	Homo sapiens	0-10
18425416-2	2008	The physiological functions of heparanase include heparan sulfate turnover, embryo development, hair growth, and wound healing.	Heparitin Sulfate	50-65	heparanase	Homo sapiens	31-41
18458672-2	2008	In previous studies, we showed that heparanase, a heparan sulfate-degrading enzyme, and vascular endothelial growth factor (VEGF) play an important role during liver development and remodeling.	Heparitin Sulfate	50-65	heparanase	Rattus norvegicus	36-46
18477453-6	2008	Surprisingly, the heparan sulfate chains of GPC3 are not required for its interaction with Hedgehog.	Heparitin Sulfate	18-33	glypican 3	Homo sapiens	44-48
18378683-0	2008	The HIV-1 envelope glycoprotein gp120 features four heparan sulfate binding domains, including the co-receptor binding site.	Heparitin Sulfate	52-67	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	32-37
18378683-1	2008	It is well established that the human immunodeficiency virus-1 envelope glycoprotein surface unit, gp120, binds to cell-associated heparan sulfate (HS).	Heparitin Sulfate	131-146	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	99-104
18378683-1	2008	It is well established that the human immunodeficiency virus-1 envelope glycoprotein surface unit, gp120, binds to cell-associated heparan sulfate (HS).	Heparitin Sulfate	148-150	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	99-104
18309353-5	2008	The modest improvement on cell killing mediated by TAT PTD in Chinese hamster ovary cells appeared to be associated with cell-surface heparan sulfate proteoglycan (HSPG) composition.	Heparitin Sulfate	134-149	LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein	Cricetulus griseus	164-168
18215127-7	2008	This site overlaps extensively with laminin"s heparin-binding site, and AChE was observed to compete with heparan sulfate for laminin binding.	Heparitin Sulfate	106-121	acetylcholinesterase	Mus musculus	72-76
18407553-1	2008	Mucopolysaccharidosis type IIIA (MPS IIIA, Sanfilippo A syndrome) is caused by mutations in the N-sulfoglucosamine sulfohydrolase (SGSH) gene and the resulting defective lysosomal degradation of the glycosaminoglycan heparan sulfate.	Heparitin Sulfate	217-232	N-sulfoglucosamine sulfohydrolase	Homo sapiens	96-129
18407553-1	2008	Mucopolysaccharidosis type IIIA (MPS IIIA, Sanfilippo A syndrome) is caused by mutations in the N-sulfoglucosamine sulfohydrolase (SGSH) gene and the resulting defective lysosomal degradation of the glycosaminoglycan heparan sulfate.	Heparitin Sulfate	217-232	N-sulfoglucosamine sulfohydrolase	Homo sapiens	131-135
18314316-2	2008	We have previously shown that WARP is a multimeric component of the chondrocyte pericellular matrix in articular cartilage and intervertebral disc, where it interacts with the basement membrane heparan sulfate proteoglycan perlecan.	Heparitin Sulfate	194-209	von Willebrand factor A domain containing 1	Mus musculus	30-34
18163458-9	2008	Further, SOS facilitated FGF-2 diffusion through Descemet"s membrane, a heparan sulfate-rich basement membrane from the cornea, suggesting a possible role in FGF-2 clearance.	Heparitin Sulfate	72-87	fibroblast growth factor 2	Mus musculus	25-30
18216069-0	2008	Matrix metalloproteinase-9 associated with heparan sulphate chains of GPI-anchored cell surface proteoglycans mediates motility of murine colon adenocarcinoma cells.	Heparitin Sulfate	43-59	matrix metallopeptidase 9	Mus musculus	0-26
18216069-6	2008	Immunoprecipitation of a LuM1 cell lysate with an anti-MMP-9 antibody resulted in co-precipitation of phosphatidylinositol-specific phospholipase C-susceptible heparan sulphate proteoglycans having 66 and 64 kDa core proteins.	Heparitin Sulfate	160-176	matrix metallopeptidase 9	Mus musculus	55-60
18216069-7	2008	Taken together, the present results demonstrate that secreted MMP-9 associates with glypican-like proteoglycans through their heparan sulphate chains, and plays a crucial role in cell motility of LuM1 cells.	Heparitin Sulfate	126-142	matrix metallopeptidase 9	Mus musculus	62-67
18281504-2	2008	Dermatan sulfate (DS) and heparan sulfate (HS) increase the rate of inhibition of thrombin by HCII in vitro, but it is unknown whether vascular glycosaminoglycans play a role in the antithrombotic effect of HCII in vivo.	Heparitin Sulfate	26-41	coagulation factor II	Mus musculus	82-90
18327914-4	2008	Here, the possibility that heparin and heparan sulfate (HS) are ligands for PECAM-1 was reinvestigated.	Heparitin Sulfate	39-54	platelet and endothelial cell adhesion molecule 1	Homo sapiens	76-83
18327914-4	2008	Here, the possibility that heparin and heparan sulfate (HS) are ligands for PECAM-1 was reinvestigated.	Heparitin Sulfate	56-58	platelet and endothelial cell adhesion molecule 1	Homo sapiens	76-83
18410855-1	2008	Mucopolysaccharidosis type IIIA, or Sanfilippo syndrome type A, is a lysosomal storage disorder caused by deficiency of heparan N-sulfamidase, resulting in defective degradation and subsequent storage of heparan sulfate.	Heparitin Sulfate	204-219	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-31
18281504-2	2008	Dermatan sulfate (DS) and heparan sulfate (HS) increase the rate of inhibition of thrombin by HCII in vitro, but it is unknown whether vascular glycosaminoglycans play a role in the antithrombotic effect of HCII in vivo.	Heparitin Sulfate	26-41	serine (or cysteine) peptidase inhibitor, clade D, member 1	Mus musculus	94-98
18281504-2	2008	Dermatan sulfate (DS) and heparan sulfate (HS) increase the rate of inhibition of thrombin by HCII in vitro, but it is unknown whether vascular glycosaminoglycans play a role in the antithrombotic effect of HCII in vivo.	Heparitin Sulfate	43-45	coagulation factor II	Mus musculus	82-90
18281504-2	2008	Dermatan sulfate (DS) and heparan sulfate (HS) increase the rate of inhibition of thrombin by HCII in vitro, but it is unknown whether vascular glycosaminoglycans play a role in the antithrombotic effect of HCII in vivo.	Heparitin Sulfate	43-45	serine (or cysteine) peptidase inhibitor, clade D, member 1	Mus musculus	94-98
18191980-5	2008	Heparan sulfate expression could be restored in all the HS-deficient clones by expression of EXT1, an enzyme that is essential for the biosynthesis of HS.	Heparitin Sulfate	0-15	exostosin-1	Cricetulus griseus	93-97
18191980-5	2008	Heparan sulfate expression could be restored in all the HS-deficient clones by expression of EXT1, an enzyme that is essential for the biosynthesis of HS.	Heparitin Sulfate	56-58	exostosin-1	Cricetulus griseus	93-97
18222122-1	2008	Heparanase, a matrix-degrading enzyme that cleaves heparan sulfate side chains from heparan sulfate proteoglycans (HSPGs), has been shown to facilitate cell invasion, migration, and extravasation of metastatic tumor cells or immune cells.	Heparitin Sulfate	51-66	heparanase	Rattus norvegicus	0-10
18230614-0	2008	Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation.	Heparitin Sulfate	9-24	fibroblast growth factor 10	Mus musculus	45-50
18230614-1	2008	FGF10, a heparan sulfate (HS)-binding growth factor, is required for branching morphogenesis of mouse submandibular glands (SMGs).	Heparitin Sulfate	9-24	fibroblast growth factor 10	Mus musculus	0-5
18230614-1	2008	FGF10, a heparan sulfate (HS)-binding growth factor, is required for branching morphogenesis of mouse submandibular glands (SMGs).	Heparitin Sulfate	26-28	fibroblast growth factor 10	Mus musculus	0-5
17996027-1	2008	Heparanase is an endo-beta-d-glucuronidase which specifically cleaves extracellular and cell surface heparan sulphates at intra-chain sites.	Heparitin Sulfate	101-118	heparanase	Rattus norvegicus	0-10
18158310-0	2008	Changes in heparan sulfate are associated with delayed wound repair, altered cell migration, adhesion and contractility in the galactosyltransferase I (beta4GalT-7) deficient form of Ehlers-Danlos syndrome.	Heparitin Sulfate	11-26	beta-1,4-galactosyltransferase 7	Homo sapiens	127-150
18158310-0	2008	Changes in heparan sulfate are associated with delayed wound repair, altered cell migration, adhesion and contractility in the galactosyltransferase I (beta4GalT-7) deficient form of Ehlers-Danlos syndrome.	Heparitin Sulfate	11-26	beta-1,4-galactosyltransferase 7	Homo sapiens	152-163
18158310-2	2008	In the invertebrates Drosophila melanogaster and Caenorhabditis elegans, mutations in beta4GalT-7 affect biosynthesis of heparan sulfate (HS), a modulator of several biological processes relevant to wound repair.	Heparitin Sulfate	121-136	beta-1,4-galactosyltransferase 7	Homo sapiens	86-97
18158310-2	2008	In the invertebrates Drosophila melanogaster and Caenorhabditis elegans, mutations in beta4GalT-7 affect biosynthesis of heparan sulfate (HS), a modulator of several biological processes relevant to wound repair.	Heparitin Sulfate	138-140	beta-1,4-galactosyltransferase 7	Homo sapiens	86-97
18158310-6	2008	Scratch wound closure was delayed in beta4GalT-7-deficient cells, which could be mimicked by enzymatic removal of HS in control cells.	Heparitin Sulfate	114-116	beta-1,4-galactosyltransferase 7	Homo sapiens	37-48
18343110-5	2008	The effectiveness of this analytical method was confirmed in binding experiments between the chips and heparin binding proteins, fibronectin and recombinant human von Willebrand factor A1 domain (rh-vWf-A1), where specific partial structures of heparin or heparan sulfate responsible for binding were identified.	Heparitin Sulfate	256-271	fibronectin 1	Homo sapiens	129-140
18165227-7	2008	A genetic interaction of dbeta3GalTII with Drosophila beta1,4-galactoslyltransferase 7 (dbeta4GalT7) or with six genes that encode enzymes contributing to the synthesis of glycosaminoglycans indicated that dbeta3GalTII is involved in heparan sulfate synthesis for wing and eye development.	Heparitin Sulfate	234-249	beta-1,3-Galactosyltransferase II	Drosophila melanogaster	25-37
18337501-0	2008	Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation.	Heparitin Sulfate	0-15	exostosin glycosyltransferase 1	Homo sapiens	37-41
18337501-0	2008	Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation.	Heparitin Sulfate	0-15	exostosin glycosyltransferase 2	Homo sapiens	46-50
18337501-0	2008	Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation.	Heparitin Sulfate	0-15	N-deacetylase and N-sulfotransferase 1	Homo sapiens	58-63
18337501-0	2008	Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation.	Heparitin Sulfate	79-94	exostosin glycosyltransferase 1	Homo sapiens	37-41
18337501-0	2008	Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation.	Heparitin Sulfate	79-94	exostosin glycosyltransferase 2	Homo sapiens	46-50
18337501-4	2008	During polymerization of the HS chain, carried out by a complex of the exostosin proteins EXT1 and EXT2, the first modification enzyme, glucosaminyl N-deacetylase/N-sulfotransferase (NDST), introduces N-sulfate groups into the growing polymer.	Heparitin Sulfate	29-31	exostosin glycosyltransferase 1	Homo sapiens	90-94
18337501-4	2008	During polymerization of the HS chain, carried out by a complex of the exostosin proteins EXT1 and EXT2, the first modification enzyme, glucosaminyl N-deacetylase/N-sulfotransferase (NDST), introduces N-sulfate groups into the growing polymer.	Heparitin Sulfate	29-31	exostosin glycosyltransferase 2	Homo sapiens	99-103
17524042-1	2008	BACKGROUND AND AIM: Heparanase is an endo-beta-glucuronidase that cleaves heparan sulfate and has been implicated in tumor angiogenesis and metastasis.	Heparitin Sulfate	74-89	heparanase	Homo sapiens	20-30
17524042-1	2008	BACKGROUND AND AIM: Heparanase is an endo-beta-glucuronidase that cleaves heparan sulfate and has been implicated in tumor angiogenesis and metastasis.	Heparitin Sulfate	74-89	glucuronidase beta	Homo sapiens	42-60
18292505-0	2008	Heparan sulfate and heparin enhance ERK phosphorylation and mediate preBCR-dependent events during B lymphopoiesis.	Heparitin Sulfate	0-15	mitogen-activated protein kinase 1	Homo sapiens	36-39
18292505-7	2008	Extending this observation, we found that treatment of preBCR+ cells with heparan sulfate before anti-micro stimulation leads to increased phosphorylation of ERK1/2.	Heparitin Sulfate	74-89	mitogen-activated protein kinase 3	Homo sapiens	158-164
18292505-9	2008	Heparin treatment of cultures induces many of the same biological effects as treatment with heparan sulfate, including elevated pERK levels in preBCR+ cells.	Heparitin Sulfate	92-107	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	128-132
17980567-7	2008	The differential expression of chondroitin sulfate, dermatan sulfate and heparan sulfate chains was determined by analyzing the mRNA expression of EXTL2 (alpha-1,4-N-acetylhexosaminyltransferase), GalNAcT (beta-1,4-N-acetylgalactosaminyltransferase), and GlcAC5E (glucuronyl C5-epimerase) as they represent crucial enzymes in GAG biosynthesis.	Heparitin Sulfate	73-88	exostosin like glycosyltransferase 2	Homo sapiens	147-152
18288398-2	2008	Heparanase is an endo-beta-d-glucuronidase, which cleaves heparan sulphate chains.	Heparitin Sulfate	58-74	heparanase	Homo sapiens	0-10
18288398-2	2008	Heparanase is an endo-beta-d-glucuronidase, which cleaves heparan sulphate chains.	Heparitin Sulfate	58-74	glucuronidase beta	Homo sapiens	22-42
18036696-2	2008	In this work we evaluate the hypothesis that HIV-1 p17 may be a heparin/heparan sulfate-binding protein.	Heparitin Sulfate	72-87	family with sequence similarity 72 member B	Homo sapiens	51-54
18645924-1	2008	Heparanase is an endo-beta- D-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix, activity that is strongly implicated in tumor metastasis and angiogenesis.	Heparitin Sulfate	72-87	heparanase	Homo sapiens	0-10
18645924-1	2008	Heparanase is an endo-beta- D-glucuronidase that is capable of cleaving heparan sulfate side chains of heparan sulfate proteoglycans on cell surfaces and the extracellular matrix, activity that is strongly implicated in tumor metastasis and angiogenesis.	Heparitin Sulfate	72-87	glucuronidase beta	Homo sapiens	22-43
18036696-5	2008	Soluble heparins and heparan sulfate but not chondroitin 4-sulfate and dextran sulfate inhibit binding of HIV-1 p17 to heparin solid phase and to activated CD4(+) T cells.	Heparitin Sulfate	21-36	family with sequence similarity 72 member B	Homo sapiens	112-115
18036696-5	2008	Soluble heparins and heparan sulfate but not chondroitin 4-sulfate and dextran sulfate inhibit binding of HIV-1 p17 to heparin solid phase and to activated CD4(+) T cells.	Heparitin Sulfate	21-36	CD4 molecule	Homo sapiens	156-159
18032524-2	2008	Heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is involved in extracellular matrix degradation and, as such, may be involved in the atherosclerotic lesion progression.	Heparitin Sulfate	44-59	heparanase	Homo sapiens	0-10
18162185-2	2008	Heparanase, the heparan sulfate-specific endo-beta-glucuronidase, is a key enzyme for the matrix degradation, yet its involvement in extravasation and invasion during pathological processes was not fully clarified in vivo.	Heparitin Sulfate	16-31	heparanase	Mus musculus	0-10
18162185-2	2008	Heparanase, the heparan sulfate-specific endo-beta-glucuronidase, is a key enzyme for the matrix degradation, yet its involvement in extravasation and invasion during pathological processes was not fully clarified in vivo.	Heparitin Sulfate	16-31	glucuronidase, beta	Mus musculus	46-64
18032524-2	2008	Heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is involved in extracellular matrix degradation and, as such, may be involved in the atherosclerotic lesion progression.	Heparitin Sulfate	61-63	heparanase	Homo sapiens	0-10
18032524-10	2008	In addition, heparanase expression inversely correlates with plasma HS levels.	Heparitin Sulfate	68-70	heparanase	Homo sapiens	13-23
17961072-0	2008	Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung.	Heparitin Sulfate	74-89	superoxide dismutase 3, extracellular	Mus musculus	0-34
17961072-5	2008	Heparan sulfate, a glycosaminoglycan, is highly abundant in the ECM and tightly binds EC-SOD.	Heparitin Sulfate	0-15	superoxide dismutase 3, extracellular	Mus musculus	86-92
17961072-6	2008	We investigated the protective role of EC-SOD by evaluating the interaction of EC-SOD with heparan sulfate in the presence of reactive oxygen species (ROS).	Heparitin Sulfate	91-106	superoxide dismutase 3, extracellular	Mus musculus	79-85
17961072-7	2008	We found that ROS-induced heparin and heparan sulfate fragments induced neutrophil chemotaxis across a modified Boyden chamber, which was inhibited by the presence of EC-SOD by scavenging oxygen radicals.	Heparitin Sulfate	38-53	superoxide dismutase 3, extracellular	Mus musculus	167-173
17961072-9	2008	In vivo, bronchoalveolar lavage fluid from EC-SOD knockout mice at 1, 14, and 28 days after asbestos exposure showed increased heparan sulfate shedding from the lung parenchyma.	Heparitin Sulfate	127-142	superoxide dismutase 3, extracellular	Mus musculus	43-49
17989358-3	2008	Heparanase (HPSE), an endo-beta-D-glucuronidase, cleaves heparan sulfate at specific sites, leading to release of growth factors that may be involved in decidualization and remodeling of the maternal vasculature.	Heparitin Sulfate	57-72	heparanase	Papio anubis	0-10
18240216-0	2008	Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.	Heparitin Sulfate	0-15	mitogen-activated protein kinase 1	Homo sapiens	26-29
18240216-6	2008	Antagonizing heparan sulfate side chain formation with beta-xyloside or the addition of soluble heparin prevented ERK activation, in addition to reducing the expression of these proadhesive/contractile proteins.	Heparitin Sulfate	13-28	mitogen-activated protein kinase 1	Homo sapiens	114-117
18240216-9	2008	CONCLUSION: The results of this study suggest that heparan sulfate-dependent ERK activation contributes to the enhanced contractile ability demonstrated by dermal fibroblasts from lesional skin of patients with scleroderma.	Heparitin Sulfate	51-66	mitogen-activated protein kinase 1	Homo sapiens	77-80
17989358-3	2008	Heparanase (HPSE), an endo-beta-D-glucuronidase, cleaves heparan sulfate at specific sites, leading to release of growth factors that may be involved in decidualization and remodeling of the maternal vasculature.	Heparitin Sulfate	57-72	heparanase	Papio anubis	12-16
18240216-11	2008	Additionally, the results suggest that antagonizing the MEK/ERK pathway is likely to modulate heparan sulfate proteoglycan activity, which in turn may have a profound effect on the fibrotic response in SSc.	Heparitin Sulfate	94-109	mitogen-activated protein kinase kinase 7	Homo sapiens	56-59
18212251-1	2008	PURPOSE: Heparanase is the predominant enzyme that cleaves heparan sulfate, the main polysaccharide in the extracellular matrix.	Heparitin Sulfate	59-74	heparanase	Homo sapiens	9-19
18240216-11	2008	Additionally, the results suggest that antagonizing the MEK/ERK pathway is likely to modulate heparan sulfate proteoglycan activity, which in turn may have a profound effect on the fibrotic response in SSc.	Heparitin Sulfate	94-109	mitogen-activated protein kinase 1	Homo sapiens	60-63
18058084-0	2008	Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy.	Heparitin Sulfate	42-58	heparanase	Homo sapiens	0-10
18058084-1	2008	AIMS/HYPOTHESIS: Recent studies suggest that loss of heparan sulphate in the glomerular basement membrane (GBM) of the kidney with diabetic nephropathy is due to the increased production of heparanase, a heparan sulphate-degrading endoglycosidase.	Heparitin Sulfate	53-69	heparanase	Homo sapiens	190-200
18058084-2	2008	Our present study addresses whether heparan sulphate with different modifications is differentially reduced in the GBM and whether heparanase selectively cleaves heparan sulphate with different domain specificities.	Heparitin Sulfate	162-178	heparanase	Homo sapiens	131-141
18213582-0	2008	Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development.	Heparitin Sulfate	26-41	sulfatase 1	Homo sapiens	61-66
18058084-5	2008	Glomerular heparanase levels were increased in diabetic nephropathy kidneys and inversely correlated with the amounts of modified heparan sulphate domains.	Heparitin Sulfate	130-146	heparanase	Homo sapiens	11-21
18213582-0	2008	Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development.	Heparitin Sulfate	26-41	sulfatase 2	Homo sapiens	71-76
18058084-7	2008	Loss of modified heparan sulphate in the GBM as a result of degradation by heparanase was confirmed by heparan sulphate staining of heparanase-treated normal kidney biopsy specimens.	Heparitin Sulfate	17-33	heparanase	Homo sapiens	75-85
18058084-7	2008	Loss of modified heparan sulphate in the GBM as a result of degradation by heparanase was confirmed by heparan sulphate staining of heparanase-treated normal kidney biopsy specimens.	Heparitin Sulfate	17-33	heparanase	Homo sapiens	132-142
18058084-7	2008	Loss of modified heparan sulphate in the GBM as a result of degradation by heparanase was confirmed by heparan sulphate staining of heparanase-treated normal kidney biopsy specimens.	Heparitin Sulfate	103-119	heparanase	Homo sapiens	75-85
18058084-7	2008	Loss of modified heparan sulphate in the GBM as a result of degradation by heparanase was confirmed by heparan sulphate staining of heparanase-treated normal kidney biopsy specimens.	Heparitin Sulfate	103-119	heparanase	Homo sapiens	132-142
18058084-8	2008	CONCLUSIONS/INTERPRETATION: Our data suggest that loss of modified heparan sulphate in the GBM is mediated by an increased heparanase presence and may play a role in the pathogenesis of diabetes-induced proteinuria.	Heparitin Sulfate	67-83	heparanase	Homo sapiens	123-133
17764451-6	2008	Two antibodies recognizing CCP2 and CCP3 were capable of blocking C3b and C4b CFA and heparan sulphate binding, but only one could inhibit DAA.	Heparitin Sulfate	86-102	AGBL carboxypeptidase 2	Homo sapiens	27-31
18278163-6	2008	They share a common mechanism of action together with the endogenous antithrombotic heparan sulfate, i.e. the catalysis of the antithrombin-mediated inhibition of factor Xa.	Heparitin Sulfate	84-99	serpin family C member 1	Homo sapiens	127-139
17764451-6	2008	Two antibodies recognizing CCP2 and CCP3 were capable of blocking C3b and C4b CFA and heparan sulphate binding, but only one could inhibit DAA.	Heparitin Sulfate	86-102	AGBL carboxypeptidase 3	Homo sapiens	36-40
17764451-3	2008	We previously reported that the KSHV complement control protein (KCP) was expressed on infected cells and virions, and could inhibit complement through decay-accelerating activity (DAA) of the classical C3 convertase and cofactor activity (CFA) for factor I (FI)-mediated degradation of C4b and C3b, as well as acting as an attachment factor for binding to heparan sulphate on permissive cells.	Heparitin Sulfate	357-373	KCP	Human gammaherpesvirus 8	32-63
17764451-3	2008	We previously reported that the KSHV complement control protein (KCP) was expressed on infected cells and virions, and could inhibit complement through decay-accelerating activity (DAA) of the classical C3 convertase and cofactor activity (CFA) for factor I (FI)-mediated degradation of C4b and C3b, as well as acting as an attachment factor for binding to heparan sulphate on permissive cells.	Heparitin Sulfate	357-373	KCP	Human gammaherpesvirus 8	65-68
18661344-1	2008	Mammalian heparanase, an endoglycosidase-degrading heparan sulfate, is synthesized as a latent 65 kDa precursor that undergoes proteolytic processing, primarily by cathepsin-L, yielding 8 kDa and 50 kDa subunits that heterodimerize to form a highly active enzyme.	Heparitin Sulfate	51-66	heparanase	Homo sapiens	10-20
18283334-1	2008	Heparanase is an endo-beta-glucuronidase capable of cleaving heparan sulfate (HS), an activity implicated in tumor metastasis.	Heparitin Sulfate	61-76	glucuronidase beta	Homo sapiens	22-40
18283334-1	2008	Heparanase is an endo-beta-glucuronidase capable of cleaving heparan sulfate (HS), an activity implicated in tumor metastasis.	Heparitin Sulfate	78-80	glucuronidase beta	Homo sapiens	22-40
18032547-5	2008	In proteinuric diseases, including membranous glomerulopathy, minimal change disease, but also IgA nephropathy and lupus nephritis, increased binding of l-selectin and MCP-1 to tubular epithelial cell (TEC) HSPGs is observed, which colocalizes with increased basolateral syndecan-1 and anti-heparan sulfate 10E4 staining.	Heparitin Sulfate	291-306	selectin, lymphocyte	Mus musculus	153-163
18032547-5	2008	In proteinuric diseases, including membranous glomerulopathy, minimal change disease, but also IgA nephropathy and lupus nephritis, increased binding of l-selectin and MCP-1 to tubular epithelial cell (TEC) HSPGs is observed, which colocalizes with increased basolateral syndecan-1 and anti-heparan sulfate 10E4 staining.	Heparitin Sulfate	291-306	chemokine (C-C motif) ligand 2	Mus musculus	168-173
18463796-7	2008	In addition, the transcript levels of all the enzymes required for the synthesis of the heparan sulfate chain were estimated in the catalase transfectant clones.	Heparitin Sulfate	88-103	catalase	Homo sapiens	132-140
18468239-9	2008	These data indicate that cell-surface heparan sulfate proteoglycans are required for PDX-1 internalization and that PDX-1 protein transduction could be a valuable strategy for inducing insulin expression in pancreatic stem/progenitor cells without requiring gene transfer technology.	Heparitin Sulfate	38-53	pancreatic and duodenal homeobox 1	Homo sapiens	85-90
18040286-4	2008	IL-2 binds perlecan via heparan sulfate chains, as enzymatic removal of heparan sulfate from splenic perlecan abolishes its ability to bind IL-2.	Heparitin Sulfate	24-39	interleukin 2	Mus musculus	0-4
18040286-4	2008	IL-2 binds perlecan via heparan sulfate chains, as enzymatic removal of heparan sulfate from splenic perlecan abolishes its ability to bind IL-2.	Heparitin Sulfate	72-87	interleukin 2	Mus musculus	0-4
18077586-0	2008	Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction.	Heparitin Sulfate	28-43	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	54-58
18077586-4	2008	Consistent with this, Fgf10-induced ectopic lacrimal gland budding in explant cultures is dependent upon Ndst gene dose, and epithelial deletion of Fgfr2 abolishes lacrimal gland budding, its specific modification of heparan sulfate and its phosphorylation of Shp2 (Ptpn11 - Mouse Genome Informatics).	Heparitin Sulfate	217-232	fibroblast growth factor 10	Mus musculus	22-27
18077586-4	2008	Consistent with this, Fgf10-induced ectopic lacrimal gland budding in explant cultures is dependent upon Ndst gene dose, and epithelial deletion of Fgfr2 abolishes lacrimal gland budding, its specific modification of heparan sulfate and its phosphorylation of Shp2 (Ptpn11 - Mouse Genome Informatics).	Heparitin Sulfate	217-232	fibroblast growth factor receptor 2	Mus musculus	148-153
18077591-5	2008	These responses require heparan sulfate, are sensitive to inhibitors of proteasomal degradation, and involve RhoA and LIM kinase activation.	Heparitin Sulfate	24-39	ras homolog family member A L homeolog	Xenopus laevis	109-113
17706452-8	2008	Both the amounts of chondroitin/dermatan/heparan sulfate and their sulfation levels differed between the cell lines and were distinctly modulated by FGF-2.	Heparitin Sulfate	41-56	fibroblast growth factor 2	Homo sapiens	149-154
18006589-0	2008	Altered glycosylation of recombinant NKp30 hampers binding to heparan sulfate: a lesson for the use of recombinant immunoreceptors as an immunological tool.	Heparitin Sulfate	62-77	natural cytotoxicity triggering receptor 3	Homo sapiens	37-42
18006589-15	2008	Overall, our results emphasize the importance of proper glycosylation for analysis of NKp30 binding to its ligand and that membranal heparan sulfate could serve as a coligand for NKp30.	Heparitin Sulfate	133-148	natural cytotoxicity triggering receptor 3	Homo sapiens	179-184
18006589-16	2008	At the cellular level, soluble heparan sulfate enhanced the secretion of IFNgamma by NK-92 natural killer cells activated with anti-NKp30 monoclonal antibody.	Heparitin Sulfate	31-46	interferon gamma	Homo sapiens	73-81
18006589-16	2008	At the cellular level, soluble heparan sulfate enhanced the secretion of IFNgamma by NK-92 natural killer cells activated with anti-NKp30 monoclonal antibody.	Heparitin Sulfate	31-46	natural cytotoxicity triggering receptor 3	Homo sapiens	132-137
18006589-17	2008	We discuss the involvement of heparan sulfate binding to NKp30 in NKp30-mediated activation of NK cells.	Heparitin Sulfate	30-45	natural cytotoxicity triggering receptor 3	Homo sapiens	66-71
17706452-9	2008	In this study, we show that chondroitin/dermatan sulfate-containing proteoglycans, likely in cooperation with heparan sulfate, participate in metastatic melanoma cell FGF-2-induced mitogenic response, which represents a novel finding and establishes the central role of sulfated glycosaminoglycans on melanoma growth.	Heparitin Sulfate	110-125	fibroblast growth factor 2	Homo sapiens	167-172
18585473-9	2008	In addition, we observed that PHEX colocalizes with heparan sulfate at the cell surface of osteoblasts.	Heparitin Sulfate	52-67	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	30-34
18782908-3	2008	Although heparan sulphate has not been found in plants, the At5g13690 gene encoding the alpha-N-acetyl-glucosaminidase (NAGLU), an enzyme involved in its catabolism, is present in the Arabidopsis genome.	Heparitin Sulfate	9-25	alpha-N-acetylglucosaminidase family / NAGLU family	Arabidopsis thaliana	88-118
18782908-3	2008	Although heparan sulphate has not been found in plants, the At5g13690 gene encoding the alpha-N-acetyl-glucosaminidase (NAGLU), an enzyme involved in its catabolism, is present in the Arabidopsis genome.	Heparitin Sulfate	9-25	alpha-N-acetylglucosaminidase family / NAGLU family	Arabidopsis thaliana	120-125
18585473-5	2008	Heparin, heparan sulfate and chondroitin sulfate inhibited PHEX catalytic activity, however among them, heparin presented the highest inhibitory activity (Ki=2.5+/-0.2 nM).	Heparitin Sulfate	9-24	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	59-63
18981681-1	2008	We have previously reported that heparan sulfate (HS) / heparan sulfate proteoglycan (HSPG, syndecan-1) expression significantly increased in the rat kidney during calcium oxalate (CaOx) nephrolithiasis.	Heparitin Sulfate	33-48	syndecan 1	Rattus norvegicus	86-90
18003778-6	2007	Concomitant removal of HS with heparinase III, confirmed by ultrastructural imaging, prevented the development of albuminuria in response to neuraminidase treatment.	Heparitin Sulfate	23-25	neuraminidase 1	Homo sapiens	141-154
18217145-8	2008	This effect was found to be independent of heparanase enzymatic activity and interaction with heparan-sulfate, and correlated with reduced TFPI levels on the cell surface.	Heparitin Sulfate	94-109	tissue factor pathway inhibitor	Homo sapiens	139-143
17971291-4	2007	Growth plate perlecan contains chondroitin sulfate (CS) and heparan sulfate (HS) chains and FGF-18 is known to bind to heparin and to heparan sulfate from some sources.	Heparitin Sulfate	134-149	fibroblast growth factor 18	Mus musculus	92-98
17959718-0	2007	Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.	Heparitin Sulfate	32-47	fibroblast growth factor 10	Mus musculus	58-63
17959718-2	2007	Heparan sulfate (HS) regulates the activity of FGFs by acting as a coreceptor at the cell surface, enhancing FGF-FGFR affinity, and being a storage reservoir for FGFs in the extracellular matrix (ECM).	Heparitin Sulfate	0-15	fibroblast growth factor 10	Mus musculus	47-50
17959718-2	2007	Heparan sulfate (HS) regulates the activity of FGFs by acting as a coreceptor at the cell surface, enhancing FGF-FGFR affinity, and being a storage reservoir for FGFs in the extracellular matrix (ECM).	Heparitin Sulfate	17-19	fibroblast growth factor 10	Mus musculus	47-50
17822686-11	2007	CONCLUSIONS: EL expression promotes the binding and uptake of native and oxidized LDL in THP-1 macrophages in a heparan sulfate proteoglycan-dependent manner, and the LDL receptor was partly responsible for the EL-enhanced uptake of native LDL.	Heparitin Sulfate	112-127	lipase G, endothelial type	Homo sapiens	13-15
18064313-2	2007	Heparanase is an endo-beta-D-glucuronidase with specific heparan sulfate degrading activity, which is produced and stored in platelets, and is released upon their activation.	Heparitin Sulfate	57-72	glucuronidase beta	Homo sapiens	22-42
17944804-1	2007	The keratinocyte growth factor receptor (KGFR)/fibroblast growth factor receptor 2b is activated by high-affinity-specific interaction with two different ligands, keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)7 and FGF10/KGF2, which are characterized by an opposite requirement of heparan sulfate proteoglycans and heparin for binding to the receptor.	Heparitin Sulfate	298-313	fibroblast growth factor receptor 2	Homo sapiens	4-39
17944804-1	2007	The keratinocyte growth factor receptor (KGFR)/fibroblast growth factor receptor 2b is activated by high-affinity-specific interaction with two different ligands, keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)7 and FGF10/KGF2, which are characterized by an opposite requirement of heparan sulfate proteoglycans and heparin for binding to the receptor.	Heparitin Sulfate	298-313	fibroblast growth factor receptor 2	Homo sapiens	41-45
17944804-1	2007	The keratinocyte growth factor receptor (KGFR)/fibroblast growth factor receptor 2b is activated by high-affinity-specific interaction with two different ligands, keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)7 and FGF10/KGF2, which are characterized by an opposite requirement of heparan sulfate proteoglycans and heparin for binding to the receptor.	Heparitin Sulfate	298-313	fibroblast growth factor receptor 2	Homo sapiens	47-82
17944804-1	2007	The keratinocyte growth factor receptor (KGFR)/fibroblast growth factor receptor 2b is activated by high-affinity-specific interaction with two different ligands, keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)7 and FGF10/KGF2, which are characterized by an opposite requirement of heparan sulfate proteoglycans and heparin for binding to the receptor.	Heparitin Sulfate	298-313	fibroblast growth factor 7	Homo sapiens	4-30
17944804-1	2007	The keratinocyte growth factor receptor (KGFR)/fibroblast growth factor receptor 2b is activated by high-affinity-specific interaction with two different ligands, keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)7 and FGF10/KGF2, which are characterized by an opposite requirement of heparan sulfate proteoglycans and heparin for binding to the receptor.	Heparitin Sulfate	298-313	fibroblast growth factor 7	Homo sapiens	41-44
17944804-1	2007	The keratinocyte growth factor receptor (KGFR)/fibroblast growth factor receptor 2b is activated by high-affinity-specific interaction with two different ligands, keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)7 and FGF10/KGF2, which are characterized by an opposite requirement of heparan sulfate proteoglycans and heparin for binding to the receptor.	Heparitin Sulfate	298-313	fibroblast growth factor 10	Homo sapiens	232-237
17944807-0	2007	A heparan sulfate-facilitated and raft-dependent macropinocytosis of eosinophil cationic protein.	Heparitin Sulfate	2-17	ribonuclease A family member 3	Homo sapiens	69-96
17944807-4	2007	Removal of cell surface heparan sulfate by heparinases or reducing glycan sulfation by chlorate markedly decreased ECP binding to human bronchial epithelial Beas-2B cells.	Heparitin Sulfate	24-39	ribonuclease A family member 3	Homo sapiens	115-118
17855358-3	2007	Chemical shift perturbation experiments allowed the precise definition of the heparan sulfate (HS) binding site of CypB.	Heparitin Sulfate	78-93	peptidylprolyl isomerase B	Homo sapiens	115-119
17855358-3	2007	Chemical shift perturbation experiments allowed the precise definition of the heparan sulfate (HS) binding site of CypB.	Heparitin Sulfate	95-97	peptidylprolyl isomerase B	Homo sapiens	115-119
17855358-5	2007	Because the HS binding site extends toward the CypB catalytic pocket, we measured its peptidyl-prolyl cis-trans isomerase (PPIase) activity in the absence or presence of a HS oligosaccharide toward a CD147-derived peptide.	Heparitin Sulfate	12-14	peptidylprolyl isomerase like 1	Homo sapiens	86-121
17855358-5	2007	Because the HS binding site extends toward the CypB catalytic pocket, we measured its peptidyl-prolyl cis-trans isomerase (PPIase) activity in the absence or presence of a HS oligosaccharide toward a CD147-derived peptide.	Heparitin Sulfate	12-14	peptidylprolyl isomerase like 1	Homo sapiens	123-129
17855358-5	2007	Because the HS binding site extends toward the CypB catalytic pocket, we measured its peptidyl-prolyl cis-trans isomerase (PPIase) activity in the absence or presence of a HS oligosaccharide toward a CD147-derived peptide.	Heparitin Sulfate	12-14	basigin (Ok blood group)	Homo sapiens	200-205
17725987-1	2007	Mucopolysaccharidosis type IIIA (MPS-IIIA or Sanfilippo syndrome) is a lysosomal storage disorder caused by the congenital deficiency of sulfamidase (SGSH) enzyme and consequent accumulation of partially degraded heparan sulfate (HS) in lysosomes.	Heparitin Sulfate	213-228	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	150-154
17725987-1	2007	Mucopolysaccharidosis type IIIA (MPS-IIIA or Sanfilippo syndrome) is a lysosomal storage disorder caused by the congenital deficiency of sulfamidase (SGSH) enzyme and consequent accumulation of partially degraded heparan sulfate (HS) in lysosomes.	Heparitin Sulfate	230-232	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	150-154
17761672-0	2007	Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.	Heparitin Sulfate	41-56	exostosin glycosyltransferase 1	Homo sapiens	16-20
17870532-0	2007	Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation.	Heparitin Sulfate	14-29	hepatocyte growth factor	Homo sapiens	54-60
17761672-0	2007	Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.	Heparitin Sulfate	41-56	exostosin like glycosyltransferase 3	Homo sapiens	32-37
17761672-1	2007	The exostosin (EXT) family of genes encodes glycosyltransferases involved in heparan sulfate biosynthesis.	Heparitin Sulfate	77-92	exostosin glycosyltransferase 1	Homo sapiens	4-13
17761672-1	2007	The exostosin (EXT) family of genes encodes glycosyltransferases involved in heparan sulfate biosynthesis.	Heparitin Sulfate	77-92	exostosin glycosyltransferase 1	Homo sapiens	15-18
17761672-3	2007	EXT1 and EXT2 are believed to form a Golgi-located hetero-oligomeric complex that catalyzes the chain elongation step in heparan sulfate biosynthesis, whereas the EXTL proteins exhibit overlapping glycosyl-transferase activities in vitro, so that it is not apparent what reactions they catalyze in vivo.	Heparitin Sulfate	121-136	exostosin glycosyltransferase 1	Homo sapiens	0-4
17761672-3	2007	EXT1 and EXT2 are believed to form a Golgi-located hetero-oligomeric complex that catalyzes the chain elongation step in heparan sulfate biosynthesis, whereas the EXTL proteins exhibit overlapping glycosyl-transferase activities in vitro, so that it is not apparent what reactions they catalyze in vivo.	Heparitin Sulfate	121-136	exostosin glycosyltransferase 2	Homo sapiens	9-13
17761672-6	2007	Compared with cells transfected with control siRNA, those transfected with EXT1 or EXT2 siRNA synthesized shorter heparan sulfate chains, and those transfected with EXTL3 siRNA synthesized longer chains.	Heparitin Sulfate	114-129	exostosin glycosyltransferase 1	Homo sapiens	75-79
17656651-0	2007	Expression of the heparan sulfate-degrading enzyme heparanase is induced in infiltrating CD4+ T cells in experimental autoimmune encephalomyelitis and regulated at the level of transcription by early growth response gene 1.	Heparitin Sulfate	18-33	CD4 molecule	Homo sapiens	89-92
17998446-1	2007	BACKGROUND: Mucopolysaccharidosis type IIID (MPS-IIID), or Sanfilippo syndrome type D, is a rare autosomal recessive lysosomal storage disorder caused by mutations in the N-acetylglucosamine-6-sulfatase (GNS) gene, leading to impaired degradation of heparan sulfate.	Heparitin Sulfate	250-265	glucosamine (N-acetyl)-6-sulfatase	Homo sapiens	171-202
18174963-1	2007	Hunter syndrome (mucopolysaccharidosis II, MPS II) is a rare X-linked lysosomal storage disorder caused by the deficiency of enzyme iduronate-2-sulfatase (I2S), which results in accumulation of undegraded dermatan and heparan sulfate in various tissues and organs.	Heparitin Sulfate	218-233	iduronate 2-sulfatase	Homo sapiens	132-153
18174963-1	2007	Hunter syndrome (mucopolysaccharidosis II, MPS II) is a rare X-linked lysosomal storage disorder caused by the deficiency of enzyme iduronate-2-sulfatase (I2S), which results in accumulation of undegraded dermatan and heparan sulfate in various tissues and organs.	Heparitin Sulfate	218-233	iduronate 2-sulfatase	Homo sapiens	155-158
17870067-2	2007	Well documented is the contribution of syndecan-4 that interacts through its heparan sulphate chains to promote focal adhesion formation in response to fibronectin domains.	Heparitin Sulfate	77-93	syndecan 4	Homo sapiens	39-49
17870067-2	2007	Well documented is the contribution of syndecan-4 that interacts through its heparan sulphate chains to promote focal adhesion formation in response to fibronectin domains.	Heparitin Sulfate	77-93	fibronectin 1	Homo sapiens	152-163
17870067-4	2007	Here an alternate pathway mediated by the extracellular domains of syndecans-2 and -4 is characterized that is independent of both heparan sulphate and syndecan signaling.	Heparitin Sulfate	131-147	syndecan 2	Homo sapiens	67-85
17804609-7	2007	Glycosaminoglycan, including heparan sulfate, synthesis was inhibited in both hIAPP transgenic and nontransgenic islets (the latter is a control that does not develop amyloid), while O-linked protein glycosylation was also decreased, and WAS-406 treatment tended to decrease islet viability in nontransgenic islets.	Heparitin Sulfate	29-44	islet amyloid polypeptide	Homo sapiens	78-83
17936096-3	2007	We have expressed the sulfotransferase domain of the human heparan sulfate 3-OST-3A isoform in Escherichia coli and subsequently purified the active enzyme which was found to be present as an oligomer under nonreducing conditions.	Heparitin Sulfate	59-74	heparan sulfate-glucosamine 3-sulfotransferase 3A1	Homo sapiens	75-83
17936096-7	2007	In cross-link assays, only HS was found to induce high molecular aggregates of 3-OST-3A whereas other GAG ligands did not or even inhibited enzyme oligomerisation like the K5 polysaccharide, which was nevertheless found to bind to the enzyme.	Heparitin Sulfate	27-29	heparan sulfate-glucosamine 3-sulfotransferase 3A1	Homo sapiens	79-87
17876721-2	2007	I2S catalyses a step in the catabolism of glycosaminoglycans (GAGs) dermatan sulfate and heparan sulfate, and when it is deficient or absent GAGs accumulate in tissues and organs.	Heparitin Sulfate	89-104	iduronate 2-sulfatase	Homo sapiens	0-3
17656651-1	2007	The heparan sulfate-cleaving enzyme heparanase (HPSE) plays an important role in remodeling of the basement membrane and extracellular matrix during inflammation.	Heparitin Sulfate	4-19	heparanase	Homo sapiens	48-52
17971873-1	2007	BACKGROUND: CXCL12alpha, a chemokine that importantly promotes the oriented cell migration and tissue homing of many cell types, regulates key homeostatic functions and pathological processes through interactions with its cognate receptor (CXCR4) and heparan sulfate (HS).	Heparitin Sulfate	251-266	C-X-C motif chemokine receptor 4	Homo sapiens	240-245
18030359-1	2007	Heparanase is an endoglycosidase that specifically cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans, the major proteoglycan in the extracellular matrix (ECM) and cell surfaces.	Heparitin Sulfate	59-74	heparanase	Homo sapiens	0-10
18030359-1	2007	Heparanase is an endoglycosidase that specifically cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans, the major proteoglycan in the extracellular matrix (ECM) and cell surfaces.	Heparitin Sulfate	76-78	heparanase	Homo sapiens	0-10
18030359-1	2007	Heparanase is an endoglycosidase that specifically cleaves heparan sulfate (HS) side chains of heparan sulfate proteoglycans, the major proteoglycan in the extracellular matrix (ECM) and cell surfaces.	Heparitin Sulfate	95-110	heparanase	Homo sapiens	0-10
29350861-0	2007	Expression of the heparan sulfate-degrading enzyme heparanase is induced in infiltrating CD4+ T cells in experimental autoimmune encephalomyelitis and regulated at the level of transcription by early growth response gene.	Heparitin Sulfate	18-33	CD4 molecule	Homo sapiens	89-92
29350861-1	2007	The heparan sulfate-cleaving enzyme heparanase (HPSE) plays an important role in remodeling of the basement membrane and extracellular matrix during inflammation.	Heparitin Sulfate	4-19	heparanase	Homo sapiens	48-52
17805240-3	2007	Heparan sulfate (HS) proteoglycans like syndecan-1 play multiple roles during inflammation and we evaluate its role in experimental anti-GBM disease using syndecan-1 knockout (sdc-1-/-) mice.	Heparitin Sulfate	0-15	syndecan 1	Mus musculus	40-50
17805240-3	2007	Heparan sulfate (HS) proteoglycans like syndecan-1 play multiple roles during inflammation and we evaluate its role in experimental anti-GBM disease using syndecan-1 knockout (sdc-1-/-) mice.	Heparitin Sulfate	0-15	syndecan 1	Mus musculus	155-165
17805240-3	2007	Heparan sulfate (HS) proteoglycans like syndecan-1 play multiple roles during inflammation and we evaluate its role in experimental anti-GBM disease using syndecan-1 knockout (sdc-1-/-) mice.	Heparitin Sulfate	17-19	syndecan 1	Mus musculus	40-50
17702986-3	2007	Here, we show that the abundant cell surface GAGs, HS and CS, are secreted in proteoglycan complexes that directly regulate the bone morphogenetic protein (BMP)-mediated differentiation of hMSCs into osteoblasts.	Heparitin Sulfate	51-53	bone morphogenetic protein 1	Homo sapiens	128-154
17702986-3	2007	Here, we show that the abundant cell surface GAGs, HS and CS, are secreted in proteoglycan complexes that directly regulate the bone morphogenetic protein (BMP)-mediated differentiation of hMSCs into osteoblasts.	Heparitin Sulfate	51-53	bone morphogenetic protein 1	Homo sapiens	156-159
17702986-7	2007	Thus, the enzymatic disruption of HS and CS chains on cell surface proteoglycans alters BMP and Wnt activity so as to enhance the lineage commitment and osteogenic differentiation of hMSCs.	Heparitin Sulfate	34-36	bone morphogenetic protein 1	Homo sapiens	88-91
17971873-1	2007	BACKGROUND: CXCL12alpha, a chemokine that importantly promotes the oriented cell migration and tissue homing of many cell types, regulates key homeostatic functions and pathological processes through interactions with its cognate receptor (CXCR4) and heparan sulfate (HS).	Heparitin Sulfate	268-270	C-X-C motif chemokine receptor 4	Homo sapiens	240-245
17849224-7	2007	PCR analysis showed significant increases in the gene expression of the osteogenic markers Runx2, alkaline phosphatase, and osteopontin in the heparin sulfate group compared with controls.	Heparitin Sulfate	143-158	RUNX family transcription factor 2	Rattus norvegicus	91-96
17689495-1	2007	The endoglycosidase heparanase is the predominant enzyme that degrades heparan sulfate side chains of heparan sulfate proteoglycans, activity that is strongly implicated in tumor metastasis.	Heparitin Sulfate	71-86	heparanase	Homo sapiens	20-30
17711860-6	2007	These results suggest that a functional FGF19 receptor may consist of FGF receptor (FGFR) and heparan sulfate complexed with either alphaKlotho or betaKlotho.	Heparitin Sulfate	94-109	fibroblast growth factor 19	Homo sapiens	40-45
17673511-0	2007	The binding of human betacellulin to heparin, heparan sulfate and related polysaccharides.	Heparitin Sulfate	46-61	betacellulin	Homo sapiens	21-33
17849224-7	2007	PCR analysis showed significant increases in the gene expression of the osteogenic markers Runx2, alkaline phosphatase, and osteopontin in the heparin sulfate group compared with controls.	Heparitin Sulfate	143-158	secreted phosphoprotein 1	Rattus norvegicus	124-135
17640876-7	2007	Fab fragments of binding-neutralizing antibody H16.56E that recognize an epitope directly adjacent to lysine residues strongly reduced HS-mediated cell binding, further corroborating our findings.	Heparitin Sulfate	135-137	FA complementation group B	Homo sapiens	0-3
17536013-1	2007	The heparan sulfate proteoglycan syndecan-1 is expressed by myeloma cells and shed into the myeloma microenvironment.	Heparitin Sulfate	4-19	syndecan 1	Homo sapiens	33-43
17726466-3	2007	Radioligand competition binding assays were performed using a range of heparin oligosaccharides to compete with polymeric heparin or heparan sulphate binding to I(125) CXCL12.	Heparitin Sulfate	133-149	C-X-C motif chemokine ligand 12	Homo sapiens	168-174
17623663-5	2007	Removal of heparan sulfate from the cell surface of low metastatic cells by treatment with heparitinase-I promoted MMP-2 activation, and transfection of syndecan-2 into highly metastatic cells suppressed MMP-2 activation.	Heparitin Sulfate	11-26	matrix metallopeptidase 2	Homo sapiens	115-120
17626017-1	2007	The longer splice isoforms of vascular endothelial growth factor-A (VEGF-A), including mouse VEGF164, contain a highly basic heparin-binding domain (HBD), which imparts the ability of these isoforms to be deposited in the heparan sulfate-rich extracellular matrix and to interact with the prototype sulfated glycosaminoglycan, heparin.	Heparitin Sulfate	222-237	vascular endothelial growth factor A	Mus musculus	30-66
17626017-1	2007	The longer splice isoforms of vascular endothelial growth factor-A (VEGF-A), including mouse VEGF164, contain a highly basic heparin-binding domain (HBD), which imparts the ability of these isoforms to be deposited in the heparan sulfate-rich extracellular matrix and to interact with the prototype sulfated glycosaminoglycan, heparin.	Heparitin Sulfate	222-237	vascular endothelial growth factor A	Mus musculus	68-74
17597060-5	2007	Mosquito heparan sulfate was found to contain the critical trisulfated disaccharide sequence, --&gt;4)beta-D-GlcNS6S(1--&gt;4)-alpha-L-IdoA2S(1--&gt;, that is commonly found in human liver heparan sulfate, which serves as the receptor for apolipoprotein E and is also believed to be responsible for binding to the circumsporozoite protein found on the surface of the Plasmodium sporozoite.	Heparitin Sulfate	9-24	apolipoprotein E	Homo sapiens	239-255
17507691-3	2007	Heparanase (HPSE) is an endo-beta-glucuronidase that cleaves HS at specific sites.	Heparitin Sulfate	61-63	heparanase	Mus musculus	0-10
17507691-3	2007	Heparanase (HPSE) is an endo-beta-glucuronidase that cleaves HS at specific sites.	Heparitin Sulfate	61-63	heparanase	Mus musculus	12-16
17507691-3	2007	Heparanase (HPSE) is an endo-beta-glucuronidase that cleaves HS at specific sites.	Heparitin Sulfate	61-63	glucuronidase, beta	Mus musculus	29-47
17896955-7	2007	There is increasing evidence that platelet factor 4 (PF4) displaced from endothelial cells, heparan sulphate or directly from the platelets, binds to heparin molecule to form an immunogenic complex.	Heparitin Sulfate	92-108	platelet factor 4	Homo sapiens	53-56
17704393-3	2007	Previous studies have suggested that glypican-1 influences fibroblast growth factor 2 (FGF2) signaling pathway by its heparan sulfate chains.	Heparitin Sulfate	118-133	glypican-1	Meleagris gallopavo	37-47
17704393-3	2007	Previous studies have suggested that glypican-1 influences fibroblast growth factor 2 (FGF2) signaling pathway by its heparan sulfate chains.	Heparitin Sulfate	118-133	fibroblast growth factor 2	Meleagris gallopavo	59-85
17704393-3	2007	Previous studies have suggested that glypican-1 influences fibroblast growth factor 2 (FGF2) signaling pathway by its heparan sulfate chains.	Heparitin Sulfate	118-133	fibroblast growth factor 2	Meleagris gallopavo	87-91
17720696-0	2007	SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.	Heparitin Sulfate	25-40	sulfatase 1	Mus musculus	0-5
17720696-0	2007	SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.	Heparitin Sulfate	25-40	sulfatase 2	Mus musculus	10-15
17720696-0	2007	SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.	Heparitin Sulfate	25-40	glial cell line derived neurotrophic factor	Mus musculus	50-54
17588949-8	2007	Using affinity co-electrophoresis, we showed that COMP/TSP5, in its calcium-replete conformation, bound to heparin, chondroitin sulfates, and heparan sulfate; this binding was reduced with EDTA treatment of COMP/TSP5.	Heparitin Sulfate	142-157	cartilage oligomeric matrix protein	Homo sapiens	50-59
17588944-0	2007	The heparin/heparan sulfate sequence that interacts with cyclophilin B contains a 3-O-sulfated N-unsubstituted glucosamine residue.	Heparitin Sulfate	12-27	peptidylprolyl isomerase B	Homo sapiens	57-70
17640047-1	2007	Sanfilippo type B is an autosomal recessive mucopolysaccharidosis (MPS IIIB) caused by deficiency of N-acetyl-alpha-D-glucosaminidase, a lysosomal enzyme involved in the degradation of heparan sulfate.	Heparitin Sulfate	185-200	N-acetyl-alpha-glucosaminidase	Homo sapiens	67-75
17588949-8	2007	Using affinity co-electrophoresis, we showed that COMP/TSP5, in its calcium-replete conformation, bound to heparin, chondroitin sulfates, and heparan sulfate; this binding was reduced with EDTA treatment of COMP/TSP5.	Heparitin Sulfate	142-157	cartilage oligomeric matrix protein	Homo sapiens	55-59
17609110-3	2007	Here we show that Lipophorin interacts with the heparan sulfate moieties of the glypicans Dally and Dally-like.	Heparitin Sulfate	48-63	apolipophorin	Drosophila melanogaster	18-28
17464092-0	2007	Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells.	Heparitin Sulfate	25-40	SRY-box transcription factor 1	Homo sapiens	95-99
17540770-1	2007	The S-nitrosylated proteoglycan glypican-1 recycles via endosomes where its heparan sulfate chains are degraded into anhydromannose-containing saccharides by NO-catalyzed deaminative cleavage.	Heparitin Sulfate	76-91	glypican 1	Homo sapiens	32-42
17540770-10	2007	In Niemann-Pick C-1 fibroblasts, where deaminative degradation of heparan sulfate is defective, carbonylated proteins were abundant.	Heparitin Sulfate	66-81	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	16-19
17540770-11	2007	Moreover, when glypican-1 expression was silenced in normal fibroblasts, the level of carbonylated proteins increased raising the possibility that deaminative heparan sulfate degradation is involved in the clearance of misfolded proteins.	Heparitin Sulfate	159-174	glypican 1	Homo sapiens	15-25
17493930-8	2007	Thus, we have shown for the first time that 2-O-sulfation of HS is essential for the FGF signaling required for limb bud development and outgrowth.	Heparitin Sulfate	61-63	fibroblast growth factor 8	Gallus gallus	85-88
17609110-3	2007	Here we show that Lipophorin interacts with the heparan sulfate moieties of the glypicans Dally and Dally-like.	Heparitin Sulfate	48-63	division abnormally delayed	Drosophila melanogaster	90-95
17609110-3	2007	Here we show that Lipophorin interacts with the heparan sulfate moieties of the glypicans Dally and Dally-like.	Heparitin Sulfate	48-63	dally-like	Drosophila melanogaster	100-110
17467664-2	2007	Heparanase is an endoglycosidase that can degrade extracellular matrix by cleaving heparan sulfate chains of heparan sulfate proteoglycan, thus playing important roles in the invasion and metastasis of human cancers.	Heparitin Sulfate	83-98	heparanase	Homo sapiens	0-10
17629845-1	2007	Heparanase is an endo-beta-D-glucuronidase that cleaves the heparan sulfate chains of heparan sulfate proteoglycans and is implicated in angiogenesis and metastasis.	Heparitin Sulfate	60-75	heparanase	Homo sapiens	0-10
17629845-1	2007	Heparanase is an endo-beta-D-glucuronidase that cleaves the heparan sulfate chains of heparan sulfate proteoglycans and is implicated in angiogenesis and metastasis.	Heparitin Sulfate	60-75	glucuronidase beta	Homo sapiens	22-42
17368052-8	2007	RESULTS: Here we have identified perlecan as the heparan sulphate proteoglycan that sequesters FGF-2 in articular cartilage.	Heparitin Sulfate	49-65	fibroblast growth factor 2	Homo sapiens	95-100
17536787-3	2007	NKp44 showed heparan sulfate-dependent binding to tumor cells; this binding was partially blocked with an antibody to heparan sulfate.	Heparitin Sulfate	13-28	natural cytotoxicity triggering receptor 2	Homo sapiens	0-5
17536787-3	2007	NKp44 showed heparan sulfate-dependent binding to tumor cells; this binding was partially blocked with an antibody to heparan sulfate.	Heparitin Sulfate	118-133	natural cytotoxicity triggering receptor 2	Homo sapiens	0-5
17536787-4	2007	In addition, direct binding of NKp44 to heparin was observed, and soluble heparin/heparan sulfate enhanced the secretion of IFNgamma by NK92 cells activated with anti-NKp44 monoclonal antibody.	Heparitin Sulfate	82-97	interferon gamma	Homo sapiens	124-132
17536787-4	2007	In addition, direct binding of NKp44 to heparin was observed, and soluble heparin/heparan sulfate enhanced the secretion of IFNgamma by NK92 cells activated with anti-NKp44 monoclonal antibody.	Heparitin Sulfate	82-97	natural cytotoxicity triggering receptor 2	Homo sapiens	167-172
17536787-5	2007	Basic amino acids, predicted to constitute the putative heparin/heparan sulfate binding site of NKp44, were mutated.	Heparitin Sulfate	64-79	natural cytotoxicity triggering receptor 2	Homo sapiens	96-101
17467664-2	2007	Heparanase is an endoglycosidase that can degrade extracellular matrix by cleaving heparan sulfate chains of heparan sulfate proteoglycan, thus playing important roles in the invasion and metastasis of human cancers.	Heparitin Sulfate	109-124	heparanase	Homo sapiens	0-10
17376755-1	2007	GlcNAc N-deacetylase/N-sulfotransferase-1 (NDST-1), a member of the enzyme family catalyzing the first modification step in the biosynthesis of heparan sulfate (HS), was knocked out in mice to investigate its role in embryonic development.	Heparitin Sulfate	144-159	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	43-49
17376755-1	2007	GlcNAc N-deacetylase/N-sulfotransferase-1 (NDST-1), a member of the enzyme family catalyzing the first modification step in the biosynthesis of heparan sulfate (HS), was knocked out in mice to investigate its role in embryonic development.	Heparitin Sulfate	161-163	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	43-49
17376755-6	2007	These results suggested that NDST-1-dependent heparan sulfate might negatively modulate BMP and its downstream PTHrP signaling, and thus affect endochondral bone development.	Heparitin Sulfate	46-61	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	29-35
17376755-6	2007	These results suggested that NDST-1-dependent heparan sulfate might negatively modulate BMP and its downstream PTHrP signaling, and thus affect endochondral bone development.	Heparitin Sulfate	46-61	parathyroid hormone-like peptide	Mus musculus	111-116
17459751-1	2007	Mucopolysaccharidosis II (MPS II; Hunter syndrome) is an X-linked metabolic disorder caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase (I2S), which catalyzes the catabolism of glycosaminoglycans (GAG) by cleaving the O-linked sulfate from dermatan sulfate and heparan sulfate.	Heparitin Sulfate	279-294	iduronate 2-sulfatase	Mus musculus	132-153
17533049-0	2007	Adiponectin binds to chemokines via the globular head and modulates interactions between chemokines and heparan sulfates.	Heparitin Sulfate	104-120	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
17459751-1	2007	Mucopolysaccharidosis II (MPS II; Hunter syndrome) is an X-linked metabolic disorder caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase (I2S), which catalyzes the catabolism of glycosaminoglycans (GAG) by cleaving the O-linked sulfate from dermatan sulfate and heparan sulfate.	Heparitin Sulfate	279-294	iduronate 2-sulfatase	Mus musculus	155-158
17437011-1	2007	Several angiogenic growth factors including fibroblast growth factors 1 and 2 (FGF1 and FGF2) depend on heparan sulphate (HS) for biological activity.	Heparitin Sulfate	104-120	fibroblast growth factor 1	Homo sapiens	44-77
17603633-1	2007	Heparanase is an endo-beta-glucuronidase that is capable of degrading heparan sulfate chains of proteoglycans, generating a variety of bioactive molecules such as growth factors and chemotactic and angiogenic agents.	Heparitin Sulfate	70-85	heparanase	Homo sapiens	0-10
17603633-1	2007	Heparanase is an endo-beta-glucuronidase that is capable of degrading heparan sulfate chains of proteoglycans, generating a variety of bioactive molecules such as growth factors and chemotactic and angiogenic agents.	Heparitin Sulfate	70-85	glucuronidase beta	Homo sapiens	22-40
17405882-3	2007	We have shown that 6-O-sulfation of the glucosamine residues in HS are catalyzed by the sulfotransferases HS6ST-1, -2, and -3.	Heparitin Sulfate	64-66	heparan sulfate 6-O-sulfotransferase 1	Mus musculus	106-125
17405882-8	2007	Biochemical studies of the HS chains isolated from various organs of our HS6ST-1-null mice revealed a marked reduction of GlcNAc(6SO(4)) and HexA-GlcNSO(3)(6SO(4)) levels and a reduced ability to bind Wnt2.	Heparitin Sulfate	27-29	heparan sulfate 6-O-sulfotransferase 1	Mus musculus	73-80
17405882-8	2007	Biochemical studies of the HS chains isolated from various organs of our HS6ST-1-null mice revealed a marked reduction of GlcNAc(6SO(4)) and HexA-GlcNSO(3)(6SO(4)) levels and a reduced ability to bind Wnt2.	Heparitin Sulfate	27-29	wingless-type MMTV integration site family, member 2	Mus musculus	201-205
17437011-1	2007	Several angiogenic growth factors including fibroblast growth factors 1 and 2 (FGF1 and FGF2) depend on heparan sulphate (HS) for biological activity.	Heparitin Sulfate	104-120	fibroblast growth factor 1	Homo sapiens	79-83
17437011-1	2007	Several angiogenic growth factors including fibroblast growth factors 1 and 2 (FGF1 and FGF2) depend on heparan sulphate (HS) for biological activity.	Heparitin Sulfate	104-120	fibroblast growth factor 2	Homo sapiens	88-92
17437011-1	2007	Several angiogenic growth factors including fibroblast growth factors 1 and 2 (FGF1 and FGF2) depend on heparan sulphate (HS) for biological activity.	Heparitin Sulfate	122-124	fibroblast growth factor 1	Homo sapiens	44-77
17437011-1	2007	Several angiogenic growth factors including fibroblast growth factors 1 and 2 (FGF1 and FGF2) depend on heparan sulphate (HS) for biological activity.	Heparitin Sulfate	122-124	fibroblast growth factor 1	Homo sapiens	79-83
17437011-1	2007	Several angiogenic growth factors including fibroblast growth factors 1 and 2 (FGF1 and FGF2) depend on heparan sulphate (HS) for biological activity.	Heparitin Sulfate	122-124	fibroblast growth factor 2	Homo sapiens	88-92
17437011-7	2007	These results indicated that, in contrast to the endothelium, HS produced by tumour cells may be modified by cell-surface heparanase (HPA1) or endosulphatase (SULF).	Heparitin Sulfate	62-64	heparanase	Homo sapiens	134-138
17363373-11	2007	Thus, the HS6ST3 enzyme in the Golgi apparatus and therefore the 6-O sulfation of heparan sulfates in the cell are at least partly regulated by beta-secretase via an indirect mechanism.	Heparitin Sulfate	82-98	LOW QUALITY PROTEIN: heparan-sulfate 6-O-sulfotransferase 3	Cricetulus griseus	10-16
17339837-2	2007	One of the key enzymes involved in specifically degrading the heparan sulphate (HS) component of the ECM is the endo-beta-glucuronidase enzyme heparanase.	Heparitin Sulfate	62-78	heparanase	Homo sapiens	143-153
17470635-5	2007	Binding of FGF-2 and VEGF(164) to cells and to purified heparan sulfate was dramatically reduced.	Heparitin Sulfate	56-71	fibroblast growth factor 2	Mus musculus	11-16
17470635-5	2007	Binding of FGF-2 and VEGF(164) to cells and to purified heparan sulfate was dramatically reduced.	Heparitin Sulfate	56-71	vascular endothelial growth factor A	Mus musculus	21-25
17347152-5	2007	Removal of heparan sulfate from the cell surface using bacterial heparitinase dramatically accelerated syndecan-1 shedding, suggesting that the effects of heparanase on syndecan-1 expression by tumor cells may be due, at least in part, to enzymatic removal or reduction in the size of heparan sulfate chains.	Heparitin Sulfate	11-26	syndecan 1	Homo sapiens	103-113
17347152-5	2007	Removal of heparan sulfate from the cell surface using bacterial heparitinase dramatically accelerated syndecan-1 shedding, suggesting that the effects of heparanase on syndecan-1 expression by tumor cells may be due, at least in part, to enzymatic removal or reduction in the size of heparan sulfate chains.	Heparitin Sulfate	11-26	syndecan 1	Homo sapiens	169-179
17613235-6	2007	Basal lamina proteins, such as fibronectin, laminin, and heparan sulfate, are also degraded by MMPs.	Heparitin Sulfate	57-72	matrix metallopeptidase 2	Homo sapiens	95-99
17384412-0	2007	The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G.	Heparitin Sulfate	47-62	elastase, neutrophil expressed	Homo sapiens	153-171
17384412-0	2007	The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G.	Heparitin Sulfate	47-62	cathepsin G	Homo sapiens	176-187
17384412-6	2007	The sulfate groups of heparan sulfate- and chondroitin sulfate-containing proteoglycans are the PMN binding sites for HLE and CG since binding of HLE and CG to PMN was inhibited by incubating PMN with 1) trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and 2) purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not with non-sulfated glycans.	Heparitin Sulfate	22-37	cathepsin G	Homo sapiens	126-128
17384412-6	2007	The sulfate groups of heparan sulfate- and chondroitin sulfate-containing proteoglycans are the PMN binding sites for HLE and CG since binding of HLE and CG to PMN was inhibited by incubating PMN with 1) trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and 2) purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not with non-sulfated glycans.	Heparitin Sulfate	22-37	cathepsin G	Homo sapiens	154-156
17384412-6	2007	The sulfate groups of heparan sulfate- and chondroitin sulfate-containing proteoglycans are the PMN binding sites for HLE and CG since binding of HLE and CG to PMN was inhibited by incubating PMN with 1) trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and 2) purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not with non-sulfated glycans.	Heparitin Sulfate	316-331	cathepsin G	Homo sapiens	126-128
17384412-6	2007	The sulfate groups of heparan sulfate- and chondroitin sulfate-containing proteoglycans are the PMN binding sites for HLE and CG since binding of HLE and CG to PMN was inhibited by incubating PMN with 1) trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and 2) purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not with non-sulfated glycans.	Heparitin Sulfate	316-331	cathepsin G	Homo sapiens	154-156
17384412-7	2007	Thus, heparan sulfate- and chondroitin sulfate-containing proteoglycans are low affinity, high volume PMN surface binding sites for HLE and CG, which are well suited to bind high concentrations of active serine proteinases released from degranulating PMN.	Heparitin Sulfate	6-21	cathepsin G	Homo sapiens	140-142
17368723-1	2007	Heparanase is an enzyme that cleaves heparan sulfate proteoglycans, an important component of the extracellular matrix to generate heparan sulfate fragments, leading to the remodeling of the extracellular matrix and the basement membrane particularly during cancer metastasis.	Heparitin Sulfate	37-52	heparanase	Rattus norvegicus	0-10
17339837-2	2007	One of the key enzymes involved in specifically degrading the heparan sulphate (HS) component of the ECM is the endo-beta-glucuronidase enzyme heparanase.	Heparitin Sulfate	80-82	heparanase	Homo sapiens	143-153
17339340-5	2007	A cleft between this region and the beta1-beta2 loop, the other heparin-binding region, precludes direct interaction between heparin/heparan sulfate and backbone atoms of FGF19/23.	Heparitin Sulfate	133-148	fibroblast growth factor 19	Homo sapiens	171-176
17635638-4	2007	Although there is evidence that several heparan sulphate-degrading endoglucuronidases (heparanases) might exist, so far only one transcript encoding a functional heparanase has been identified: heparanase-1.	Heparitin Sulfate	40-56	heparanase	Homo sapiens	194-206
17339340-7	2007	Klotho/betaKlotho have evolved as a compensatory mechanism for the poor ability of heparin/heparan sulfate to promote binding of FGF19, -21, and -23 to their cognate receptors.	Heparitin Sulfate	91-106	klotho	Homo sapiens	0-6
17339340-7	2007	Klotho/betaKlotho have evolved as a compensatory mechanism for the poor ability of heparin/heparan sulfate to promote binding of FGF19, -21, and -23 to their cognate receptors.	Heparitin Sulfate	91-106	klotho beta	Homo sapiens	7-17
17339340-7	2007	Klotho/betaKlotho have evolved as a compensatory mechanism for the poor ability of heparin/heparan sulfate to promote binding of FGF19, -21, and -23 to their cognate receptors.	Heparitin Sulfate	91-106	fibroblast growth factor 19	Homo sapiens	129-134
17442818-0	2007	Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate.	Heparitin Sulfate	91-106	netrin 1	Homo sapiens	0-8
17171641-8	2007	It has been reported that CCN1/Cyr61 exerts its functions via interacting with at least five integrins as well as heparan sulfate proteoglycan.	Heparitin Sulfate	114-129	cellular communication network factor 1	Homo sapiens	26-30
17171641-8	2007	It has been reported that CCN1/Cyr61 exerts its functions via interacting with at least five integrins as well as heparan sulfate proteoglycan.	Heparitin Sulfate	114-129	cellular communication network factor 1	Homo sapiens	31-36
17403572-3	2007	Heparan sulfate has been shown to be essential for GDNF signaling and altering the levels of heparan sulfate promotes or inhibits GDNF functional activity.	Heparitin Sulfate	0-15	glial cell derived neurotrophic factor	Homo sapiens	51-55
17403572-3	2007	Heparan sulfate has been shown to be essential for GDNF signaling and altering the levels of heparan sulfate promotes or inhibits GDNF functional activity.	Heparitin Sulfate	93-108	glial cell derived neurotrophic factor	Homo sapiens	130-134
17442818-0	2007	Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate.	Heparitin Sulfate	91-106	DCC netrin 1 receptor	Homo sapiens	9-12
17442818-4	2007	We used the Wnt1-Cre transgene to drive region-specific ablation of Ext1, which encodes an enzyme essential for HS synthesis, in the dorsal part of the spinal cord.	Heparitin Sulfate	112-114	Wnt family member 1	Homo sapiens	12-16
17442818-4	2007	We used the Wnt1-Cre transgene to drive region-specific ablation of Ext1, which encodes an enzyme essential for HS synthesis, in the dorsal part of the spinal cord.	Heparitin Sulfate	112-114	exostosin glycosyltransferase 1	Homo sapiens	68-72
17442818-8	2007	These results demonstrate that the expression of HS by commissural neurons is essential for these neurons to transduce netrin-1 signals, thus providing evidence for a cell-autonomous role of HS in netrin-1/DCC-mediated axon guidance.	Heparitin Sulfate	49-51	netrin 1	Homo sapiens	119-127
17442818-8	2007	These results demonstrate that the expression of HS by commissural neurons is essential for these neurons to transduce netrin-1 signals, thus providing evidence for a cell-autonomous role of HS in netrin-1/DCC-mediated axon guidance.	Heparitin Sulfate	49-51	netrin 1	Homo sapiens	197-205
17442818-8	2007	These results demonstrate that the expression of HS by commissural neurons is essential for these neurons to transduce netrin-1 signals, thus providing evidence for a cell-autonomous role of HS in netrin-1/DCC-mediated axon guidance.	Heparitin Sulfate	49-51	DCC netrin 1 receptor	Homo sapiens	206-209
17442818-8	2007	These results demonstrate that the expression of HS by commissural neurons is essential for these neurons to transduce netrin-1 signals, thus providing evidence for a cell-autonomous role of HS in netrin-1/DCC-mediated axon guidance.	Heparitin Sulfate	191-193	netrin 1	Homo sapiens	119-127
17442818-8	2007	These results demonstrate that the expression of HS by commissural neurons is essential for these neurons to transduce netrin-1 signals, thus providing evidence for a cell-autonomous role of HS in netrin-1/DCC-mediated axon guidance.	Heparitin Sulfate	191-193	netrin 1	Homo sapiens	197-205
17442818-8	2007	These results demonstrate that the expression of HS by commissural neurons is essential for these neurons to transduce netrin-1 signals, thus providing evidence for a cell-autonomous role of HS in netrin-1/DCC-mediated axon guidance.	Heparitin Sulfate	191-193	DCC netrin 1 receptor	Homo sapiens	206-209
17185018-1	2007	The neurodegenerative disease MPS III B (Sanfilippo syndrome type B) is caused by mutations in the gene encoding the lysosomal enzyme alpha-N-acetylglucosaminidase, with a resulting block in heparan sulfate degradation.	Heparitin Sulfate	191-206	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	134-163
17326680-5	2007	Fibers were coated, after processing, with perlecan domain I (PlnDI) to improve binding of basic fibroblast growth factor (FGF-2), which binds to native heparan sulfate chains on PlnDI.	Heparitin Sulfate	153-168	fibroblast growth factor 2	Homo sapiens	123-128
17213834-1	2007	Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate (HS) and plays an important role in tumor metastasis, angiogenesis and inflammation.	Heparitin Sulfate	53-68	heparanase	Mus musculus	0-10
17213834-1	2007	Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate (HS) and plays an important role in tumor metastasis, angiogenesis and inflammation.	Heparitin Sulfate	53-68	heparanase	Mus musculus	12-16
17213834-1	2007	Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate (HS) and plays an important role in tumor metastasis, angiogenesis and inflammation.	Heparitin Sulfate	70-72	heparanase	Mus musculus	0-10
17213834-1	2007	Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate (HS) and plays an important role in tumor metastasis, angiogenesis and inflammation.	Heparitin Sulfate	70-72	heparanase	Mus musculus	12-16
17505986-6	2007	Microarray analysis revealed several host genes were selectively upregulated by a HAD-derived tat clone including an enzyme mediating heparan sulphate synthesis, HS3ST3B1 (p &lt; 0.05), which was also found to be increased in the brains of patients with HAD.	Heparitin Sulfate	134-150	heparan sulfate-glucosamine 3-sulfotransferase 3B1	Homo sapiens	162-170
17169545-2	2007	Heparan sulfate (HS) proteoglycans bind FGF-2.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Mus musculus	40-45
17169545-2	2007	Heparan sulfate (HS) proteoglycans bind FGF-2.	Heparitin Sulfate	17-19	fibroblast growth factor 2	Mus musculus	40-45
17255131-6	2007	Furthermore, the effects of removal of HS on TNF-alpha-activated mGEnC-1 by heparinase III treatment, and of different concentrations of heparin, tinzaparin and HS, on the rolling and adhesion of leucocytes were evaluated.	Heparitin Sulfate	39-41	tumor necrosis factor	Mus musculus	45-54
17237233-0	2007	Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.	Heparitin Sulfate	116-131	Exostosin-1 homolog	Caenorhabditis elegans	14-19
17237233-1	2007	The proteins encoded by all of the five cloned human EXT family genes (EXT1, EXT2, EXTL1, EXTL2, and EXTL3), members of the hereditary multiple exostoses gene family of tumor suppressors, are glycosyltransferases required for the biosynthesis of heparan sulfate.	Heparitin Sulfate	246-261	exostosin glycosyltransferase 1	Homo sapiens	71-75
17237233-0	2007	Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.	Heparitin Sulfate	116-131	exostosin glycosyltransferase 1	Homo sapiens	84-87
17237233-1	2007	The proteins encoded by all of the five cloned human EXT family genes (EXT1, EXT2, EXTL1, EXTL2, and EXTL3), members of the hereditary multiple exostoses gene family of tumor suppressors, are glycosyltransferases required for the biosynthesis of heparan sulfate.	Heparitin Sulfate	246-261	exostosin glycosyltransferase 2	Homo sapiens	77-81
17237233-1	2007	The proteins encoded by all of the five cloned human EXT family genes (EXT1, EXT2, EXTL1, EXTL2, and EXTL3), members of the hereditary multiple exostoses gene family of tumor suppressors, are glycosyltransferases required for the biosynthesis of heparan sulfate.	Heparitin Sulfate	246-261	exostosin glycosyltransferase 1	Homo sapiens	53-56
17237233-1	2007	The proteins encoded by all of the five cloned human EXT family genes (EXT1, EXT2, EXTL1, EXTL2, and EXTL3), members of the hereditary multiple exostoses gene family of tumor suppressors, are glycosyltransferases required for the biosynthesis of heparan sulfate.	Heparitin Sulfate	246-261	exostosin like glycosyltransferase 1	Homo sapiens	83-88
17226760-7	2007	Intracellular accumulation of syndecan-2 and heparan sulphate-bearing isoforms of CD44 (CD44v3) was found in most tumours, which concentrated in the Golgi apparatus as shown by confocal microscopy.	Heparitin Sulfate	45-61	CD44 molecule (Indian blood group)	Homo sapiens	82-86
17237233-1	2007	The proteins encoded by all of the five cloned human EXT family genes (EXT1, EXT2, EXTL1, EXTL2, and EXTL3), members of the hereditary multiple exostoses gene family of tumor suppressors, are glycosyltransferases required for the biosynthesis of heparan sulfate.	Heparitin Sulfate	246-261	exostosin like glycosyltransferase 3	Homo sapiens	101-106
17237233-3	2007	Although rib-2 encodes an N-acetylglucosaminyltransferase involved in initiating the biosynthesis and elongation of heparan sulfate, the involvement of the protein encoded by rib-1 in the biosynthesis of heparan sulfate remains unclear.	Heparitin Sulfate	116-131	Exostosin-2 homolog	Caenorhabditis elegans	9-14
17237233-3	2007	Although rib-2 encodes an N-acetylglucosaminyltransferase involved in initiating the biosynthesis and elongation of heparan sulfate, the involvement of the protein encoded by rib-1 in the biosynthesis of heparan sulfate remains unclear.	Heparitin Sulfate	204-219	Exostosin-2 homolog	Caenorhabditis elegans	9-14
17237233-3	2007	Although rib-2 encodes an N-acetylglucosaminyltransferase involved in initiating the biosynthesis and elongation of heparan sulfate, the involvement of the protein encoded by rib-1 in the biosynthesis of heparan sulfate remains unclear.	Heparitin Sulfate	204-219	ribonuclease A family member 1, pancreatic	Homo sapiens	175-180
17237233-5	2007	Despite little individual glycosyltransferase activity by RIB-1, the polymerization of heparan sulfate chains was demonstrated when RIB-1 was coexpressed with RIB-2 in vitro.	Heparitin Sulfate	87-102	ribonuclease A family member 1, pancreatic	Homo sapiens	132-137
17237233-5	2007	Despite little individual glycosyltransferase activity by RIB-1, the polymerization of heparan sulfate chains was demonstrated when RIB-1 was coexpressed with RIB-2 in vitro.	Heparitin Sulfate	87-102	Exostosin-2 homolog	Caenorhabditis elegans	159-164
17237233-12	2007	Thus, RIB-1 in addition to RIB-2 is indispensable for the biosynthesis of heparan sulfate in C. elegans, and the two cooperate to synthesize heparan sulfate in vivo.	Heparitin Sulfate	74-89	Exostosin-1 homolog	Caenorhabditis elegans	6-11
17237233-12	2007	Thus, RIB-1 in addition to RIB-2 is indispensable for the biosynthesis of heparan sulfate in C. elegans, and the two cooperate to synthesize heparan sulfate in vivo.	Heparitin Sulfate	74-89	Exostosin-2 homolog	Caenorhabditis elegans	27-32
17237233-12	2007	Thus, RIB-1 in addition to RIB-2 is indispensable for the biosynthesis of heparan sulfate in C. elegans, and the two cooperate to synthesize heparan sulfate in vivo.	Heparitin Sulfate	141-156	Exostosin-1 homolog	Caenorhabditis elegans	6-11
17351980-3	2007	METHODS: We have identified several receptors that are over-expressed on tumor cells and created a series of pseudotyped Ad5 vectors that recognize these receptors: Ad5-RGD which binds alpha(v)beta3/alpha(v)beta5 integrins; Ad5/3 which contains adenovirus serotype 3 knob and binds to CD46; Ad5-Sigma which incorporates the reovirus sigma knob and binds to junctional adhesion molecule-1; and Ad5-pk7 which contains the polylysine motif and binds heparan sulfate proteoglycans.	Heparitin Sulfate	447-462	Alzheimer disease, familial, type 5	Homo sapiens	121-124
17351980-3	2007	METHODS: We have identified several receptors that are over-expressed on tumor cells and created a series of pseudotyped Ad5 vectors that recognize these receptors: Ad5-RGD which binds alpha(v)beta3/alpha(v)beta5 integrins; Ad5/3 which contains adenovirus serotype 3 knob and binds to CD46; Ad5-Sigma which incorporates the reovirus sigma knob and binds to junctional adhesion molecule-1; and Ad5-pk7 which contains the polylysine motif and binds heparan sulfate proteoglycans.	Heparitin Sulfate	447-462	Alzheimer disease, familial, type 5	Homo sapiens	165-168
17351980-3	2007	METHODS: We have identified several receptors that are over-expressed on tumor cells and created a series of pseudotyped Ad5 vectors that recognize these receptors: Ad5-RGD which binds alpha(v)beta3/alpha(v)beta5 integrins; Ad5/3 which contains adenovirus serotype 3 knob and binds to CD46; Ad5-Sigma which incorporates the reovirus sigma knob and binds to junctional adhesion molecule-1; and Ad5-pk7 which contains the polylysine motif and binds heparan sulfate proteoglycans.	Heparitin Sulfate	447-462	Alzheimer disease, familial, type 5	Homo sapiens	165-168
17351980-3	2007	METHODS: We have identified several receptors that are over-expressed on tumor cells and created a series of pseudotyped Ad5 vectors that recognize these receptors: Ad5-RGD which binds alpha(v)beta3/alpha(v)beta5 integrins; Ad5/3 which contains adenovirus serotype 3 knob and binds to CD46; Ad5-Sigma which incorporates the reovirus sigma knob and binds to junctional adhesion molecule-1; and Ad5-pk7 which contains the polylysine motif and binds heparan sulfate proteoglycans.	Heparitin Sulfate	447-462	Alzheimer disease, familial, type 5	Homo sapiens	165-168
17351980-3	2007	METHODS: We have identified several receptors that are over-expressed on tumor cells and created a series of pseudotyped Ad5 vectors that recognize these receptors: Ad5-RGD which binds alpha(v)beta3/alpha(v)beta5 integrins; Ad5/3 which contains adenovirus serotype 3 knob and binds to CD46; Ad5-Sigma which incorporates the reovirus sigma knob and binds to junctional adhesion molecule-1; and Ad5-pk7 which contains the polylysine motif and binds heparan sulfate proteoglycans.	Heparitin Sulfate	447-462	Alzheimer disease, familial, type 5	Homo sapiens	165-168
17226760-7	2007	Intracellular accumulation of syndecan-2 and heparan sulphate-bearing isoforms of CD44 (CD44v3) was found in most tumours, which concentrated in the Golgi apparatus as shown by confocal microscopy.	Heparitin Sulfate	45-61	CD44 molecule (Indian blood group)	Homo sapiens	88-94
17189265-3	2007	Here, we report the enzymatic activity of XT-II and provide evidence that XT-II initiates the biosynthesis of both heparan sulfate and chondroitin sulfate GAGs.	Heparitin Sulfate	115-130	xylosyltransferase 2	Homo sapiens	42-47
17189265-3	2007	Here, we report the enzymatic activity of XT-II and provide evidence that XT-II initiates the biosynthesis of both heparan sulfate and chondroitin sulfate GAGs.	Heparitin Sulfate	115-130	xylosyltransferase 2	Homo sapiens	74-79
17189265-5	2007	GAG disaccharide analysis revealed that XT-I- and XT-II-transfected pgsA-745 cells produced similar amounts of chondroitin sulfate and heparan sulfate.	Heparitin Sulfate	135-150	xylosyltransferase 1	Homo sapiens	40-44
17189265-5	2007	GAG disaccharide analysis revealed that XT-I- and XT-II-transfected pgsA-745 cells produced similar amounts of chondroitin sulfate and heparan sulfate.	Heparitin Sulfate	135-150	xylosyltransferase 2	Homo sapiens	50-55
17189265-11	2007	This is the first report on the enzyme activity of XT-II and its involvement in chondroitin sulfate and heparan sulfate biosynthesis.	Heparitin Sulfate	104-119	xylosyltransferase 2	Homo sapiens	51-56
17189266-0	2007	Biosynthesis of chondroitin and heparan sulfate in chinese hamster ovary cells depends on xylosyltransferase II.	Heparitin Sulfate	32-47	xylosyltransferase 2	Cricetulus griseus	90-111
17189266-7	2007	Transfection of this cell line with a murine Xylt2 minigene results in the production of recombinant chondroitin sulfate-modified biglycan core protein and restoration of fibroblast growth factor binding to cell surface-associated heparan sulfate.	Heparitin Sulfate	231-246	xylosyltransferase II	Mus musculus	45-50
17183530-0	2007	Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development.	Heparitin Sulfate	0-15	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	16-21
17317573-5	2007	We also demonstrated that heparan sulfate and chondroitin sulfate interact in a sulfation-dependent manner with various axon guidance proteins, including slit2, netrin1, ephrinA1, ephrinA5, and semaphorin5B.	Heparitin Sulfate	26-41	slit guidance ligand 2	Homo sapiens	154-159
17317573-5	2007	We also demonstrated that heparan sulfate and chondroitin sulfate interact in a sulfation-dependent manner with various axon guidance proteins, including slit2, netrin1, ephrinA1, ephrinA5, and semaphorin5B.	Heparitin Sulfate	26-41	netrin 1	Homo sapiens	161-168
17317573-5	2007	We also demonstrated that heparan sulfate and chondroitin sulfate interact in a sulfation-dependent manner with various axon guidance proteins, including slit2, netrin1, ephrinA1, ephrinA5, and semaphorin5B.	Heparitin Sulfate	26-41	ephrin A1	Homo sapiens	170-178
17317573-5	2007	We also demonstrated that heparan sulfate and chondroitin sulfate interact in a sulfation-dependent manner with various axon guidance proteins, including slit2, netrin1, ephrinA1, ephrinA5, and semaphorin5B.	Heparitin Sulfate	26-41	ephrin A5	Homo sapiens	180-188
17317573-5	2007	We also demonstrated that heparan sulfate and chondroitin sulfate interact in a sulfation-dependent manner with various axon guidance proteins, including slit2, netrin1, ephrinA1, ephrinA5, and semaphorin5B.	Heparitin Sulfate	26-41	semaphorin 5B	Homo sapiens	194-206
17183530-2	2007	We previously reported severe developmental defects of the forebrain and the skull in mutant mice bearing a targeted disruption of the heparan sulfate-generating enzyme GlcNAc N-deacetylase/GlcN N-sulfotransferase 1 (Ndst1).	Heparitin Sulfate	135-150	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	217-222
16630654-7	2007	Additionally, the basement membrane HSPG, perlecan was found to contain both CS/DS and HS in GDM placentas and plain HS in controls.	Heparitin Sulfate	87-89	syndecan 2	Homo sapiens	36-40
17250598-1	2007	OBJECTIVE: Heparanase, an endoglycosidase that cleaves heparan sulphate, is frequently expressed in carcinomas and was suggested to play a role in cell invasion and metastasis.	Heparitin Sulfate	55-71	heparanase	Homo sapiens	11-21
17011249-0	2007	Bacterially expressed and refolded envelope protein (domain III) of dengue virus type-4 binds heparan sulfate.	Heparitin Sulfate	94-109	endogenous retrovirus group K member 6, envelope	Homo sapiens	35-51
17011249-4	2007	Here we report molecular interaction of domain III of envelope protein of dengue virus type-4 with heparan sulfate.	Heparitin Sulfate	99-114	endogenous retrovirus group K member 6, envelope	Homo sapiens	54-70
17011249-9	2007	This is the first report providing molecular evidence on binding of dengue-4 envelope protein to heparan sulfate.	Heparitin Sulfate	97-112	endogenous retrovirus group K member 6, envelope	Homo sapiens	77-93
17011249-10	2007	We developed a homology model of dengue-4 envelope protein (domain III) and mapped the possible amino acid residues critical for binding to heparan sulfate.	Heparitin Sulfate	140-155	endogenous retrovirus group K member 6, envelope	Homo sapiens	42-58
17195182-4	2007	HS 2-O-sulfotransferase (2-OST) catalyzes the transfer of sulfate groups to the 2-O position of uronic acid residues of HS.	Heparitin Sulfate	0-2	heparan sulfate 2-O-sulfotransferase 1a	Danio rerio	3-23
17195182-4	2007	HS 2-O-sulfotransferase (2-OST) catalyzes the transfer of sulfate groups to the 2-O position of uronic acid residues of HS.	Heparitin Sulfate	0-2	heparan sulfate 2-O-sulfotransferase 1a	Danio rerio	25-30
16899336-9	2007	The effect of terazosin on GAGs and MMP-2 may contribute in the molecular mechanisms of terazosin-induced apoptosis because HS and CS have a proapoptotic effect, whereas DS and MMP-2 are antiapoptotic.	Heparitin Sulfate	124-126	matrix metallopeptidase 2	Rattus norvegicus	36-41
18086370-10	2007	The heparan sulfate proteoglycan syndecan-3 binds VLPs and is expressed on both DCs and LCs.	Heparitin Sulfate	4-19	syndecan 3	Homo sapiens	33-43
17145752-4	2007	Interestingly, Ser-62 of proMBP is substituted with a glycosaminoglycan (GAG) chain, possibly a heparan sulfate type, and the PAPP-A.proMBP complex is unable to bind to the cell surface.	Heparitin Sulfate	96-111	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	25-31
17227588-2	2007	The disease is caused by a deficiency of the lysosomal enzyme sulphamidase and results in the storage of the glycosaminoglycan (GAG), heparan sulphate.	Heparitin Sulfate	134-150	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	62-74
17503732-3	2007	We hypothesized that heparan sulfate (HS) administration would stimulate neural stem cell proliferation by dimerizing with FGF-2 and binding to the FGF-2 receptor on neural stem cells, thus enhancing the number of newly generated neurons to repair damage following a metabolic crisis.	Heparitin Sulfate	21-36	fibroblast growth factor 2	Mus musculus	123-128
17503732-3	2007	We hypothesized that heparan sulfate (HS) administration would stimulate neural stem cell proliferation by dimerizing with FGF-2 and binding to the FGF-2 receptor on neural stem cells, thus enhancing the number of newly generated neurons to repair damage following a metabolic crisis.	Heparitin Sulfate	21-36	fibroblast growth factor 2	Mus musculus	148-153
17503732-3	2007	We hypothesized that heparan sulfate (HS) administration would stimulate neural stem cell proliferation by dimerizing with FGF-2 and binding to the FGF-2 receptor on neural stem cells, thus enhancing the number of newly generated neurons to repair damage following a metabolic crisis.	Heparitin Sulfate	38-40	fibroblast growth factor 2	Mus musculus	123-128
17503732-3	2007	We hypothesized that heparan sulfate (HS) administration would stimulate neural stem cell proliferation by dimerizing with FGF-2 and binding to the FGF-2 receptor on neural stem cells, thus enhancing the number of newly generated neurons to repair damage following a metabolic crisis.	Heparitin Sulfate	38-40	fibroblast growth factor 2	Mus musculus	148-153
17149999-9	2007	These data indicate that cell surface heparan sulfate proteoglycans are required for BETA2/NeuroD internalization and that BETA2/NeuroD protein transduction could be a safe and valuable strategy for enhancing insulin gene transcription without requiring gene transfer technology.	Heparitin Sulfate	38-53	insulin	Cricetulus griseus	209-216
17191030-8	2007	It has previously been shown that anosmin-1 enhances FGFR1 signalling in a heparan sulphate-dependent manner, and proposed that anosmin-1 fine-tunes FGFR1 signalling during olfactory and GnRH neuronal development.	Heparitin Sulfate	75-91	anosmin 1	Homo sapiens	34-43
17191030-8	2007	It has previously been shown that anosmin-1 enhances FGFR1 signalling in a heparan sulphate-dependent manner, and proposed that anosmin-1 fine-tunes FGFR1 signalling during olfactory and GnRH neuronal development.	Heparitin Sulfate	75-91	fibroblast growth factor receptor 1	Homo sapiens	53-58
17191030-8	2007	It has previously been shown that anosmin-1 enhances FGFR1 signalling in a heparan sulphate-dependent manner, and proposed that anosmin-1 fine-tunes FGFR1 signalling during olfactory and GnRH neuronal development.	Heparitin Sulfate	75-91	anosmin 1	Homo sapiens	128-137
17191030-8	2007	It has previously been shown that anosmin-1 enhances FGFR1 signalling in a heparan sulphate-dependent manner, and proposed that anosmin-1 fine-tunes FGFR1 signalling during olfactory and GnRH neuronal development.	Heparitin Sulfate	75-91	fibroblast growth factor receptor 1	Homo sapiens	149-154
17121850-0	2007	In vivo and in vitro degradation of heparan sulfate (HS) proteoglycans by HPR1 in pancreatic adenocarcinomas.	Heparitin Sulfate	36-51	heparanase	Homo sapiens	74-78
17121850-0	2007	In vivo and in vitro degradation of heparan sulfate (HS) proteoglycans by HPR1 in pancreatic adenocarcinomas.	Heparitin Sulfate	53-55	heparanase	Homo sapiens	74-78
17121850-4	2007	In the present study, we demonstrated that HPR1 expression in pancreatic adenocarcinomas inversely correlated with the presence of heparan sulfate (HS) in the basement membrane.	Heparitin Sulfate	131-146	heparanase	Homo sapiens	43-47
17121850-4	2007	In the present study, we demonstrated that HPR1 expression in pancreatic adenocarcinomas inversely correlated with the presence of heparan sulfate (HS) in the basement membrane.	Heparitin Sulfate	148-150	heparanase	Homo sapiens	43-47
17121850-5	2007	In vitro cell culture study revealed that cell surface HS levels inversely correlated with HPR1 activity in five pancreatic cancer cell lysates and their conditioned media.	Heparitin Sulfate	55-57	heparanase	Homo sapiens	91-95
17121850-6	2007	Heparin and PI-88, two HPR1 inhibitors, were able to increase cell surface HS levels in PANC-1 cells in a dose-dependent manner.	Heparitin Sulfate	75-77	heparanase	Homo sapiens	23-27
17121850-7	2007	The ability of HPR1 to degrade cell surface HS was confirmed by showing that cell surface HS levels were increased in HT1080 cells stably transfected with the HPR1 antisense gene but was decreased in the cells overexpressing HPR1.	Heparitin Sulfate	44-46	heparanase	Homo sapiens	15-19
17121850-7	2007	The ability of HPR1 to degrade cell surface HS was confirmed by showing that cell surface HS levels were increased in HT1080 cells stably transfected with the HPR1 antisense gene but was decreased in the cells overexpressing HPR1.	Heparitin Sulfate	44-46	heparanase	Homo sapiens	159-163
17121850-7	2007	The ability of HPR1 to degrade cell surface HS was confirmed by showing that cell surface HS levels were increased in HT1080 cells stably transfected with the HPR1 antisense gene but was decreased in the cells overexpressing HPR1.	Heparitin Sulfate	44-46	heparanase	Homo sapiens	159-163
17095861-1	2007	Heparanase is a mammalian endoglucuronidase responsible for heparan sulfate (HS) degradation.	Heparitin Sulfate	60-75	heparanase	Homo sapiens	0-10
17095861-1	2007	Heparanase is a mammalian endoglucuronidase responsible for heparan sulfate (HS) degradation.	Heparitin Sulfate	77-79	heparanase	Homo sapiens	0-10
17365019-2	2007	Heparan sulfate (HS) has been shown to both improve immune cell proliferative responses and to induce Th1 cytokine responses in normal animals.	Heparitin Sulfate	0-15	negative elongation factor complex member C/D, Th1l	Mus musculus	102-105
17365019-2	2007	Heparan sulfate (HS) has been shown to both improve immune cell proliferative responses and to induce Th1 cytokine responses in normal animals.	Heparitin Sulfate	17-19	negative elongation factor complex member C/D, Th1l	Mus musculus	102-105
18086370-11	2007	Binding of VLPs to DCs, but not to LCs, strongly correlated with the levels of heparan sulfates and syndecan-3, suggesting that syndecan-3 is the main receptor for HPV-L1 VLPs on DCs.	Heparitin Sulfate	79-95	syndecan 3	Homo sapiens	128-138
17041566-1	2007	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, yielding HS fragments of still appreciable size ( approximately 5-7 kDa).	Heparitin Sulfate	63-78	heparanase	Homo sapiens	0-10
17169974-7	2007	NEX-2 bound to heparan sulfate and chondroitin, NEX-3 bound only to heparan sulfate, and NEX-1 showed no lectin activities under tested conditions.	Heparitin Sulfate	15-30	Annexin	Caenorhabditis elegans	0-5
17169974-7	2007	NEX-2 bound to heparan sulfate and chondroitin, NEX-3 bound only to heparan sulfate, and NEX-1 showed no lectin activities under tested conditions.	Heparitin Sulfate	68-83	Annexin	Caenorhabditis elegans	48-53
17200715-1	2007	We examined the role of hepatic heparan sulfate in triglyceride-rich lipoprotein metabolism by inactivating the biosynthetic gene GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) in hepatocytes using the Cre-loxP system, which resulted in an approximately 50% reduction in sulfation of liver heparan sulfate.	Heparitin Sulfate	32-47	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	173-178
17200715-1	2007	We examined the role of hepatic heparan sulfate in triglyceride-rich lipoprotein metabolism by inactivating the biosynthetic gene GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) in hepatocytes using the Cre-loxP system, which resulted in an approximately 50% reduction in sulfation of liver heparan sulfate.	Heparitin Sulfate	293-308	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	173-178
17200715-3	2007	Compounding the mutation with LDL receptor deficiency caused enhanced accumulation of both cholesterol- and triglyceride-rich particles compared with mice lacking only LDL receptors, suggesting that heparan sulfate participates in the clearance of cholesterol-rich lipoproteins as well.	Heparitin Sulfate	199-214	low density lipoprotein receptor	Mus musculus	30-42
17051597-0	2007	Heparan sulfate regulates the anabolic activity of MC3T3-E1 preosteoblast cells by induction of Runx2.	Heparitin Sulfate	0-15	runt related transcription factor 2	Mus musculus	96-101
17041566-1	2007	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, yielding HS fragments of still appreciable size ( approximately 5-7 kDa).	Heparitin Sulfate	80-82	glucuronidase beta	Homo sapiens	22-42
17041566-1	2007	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, yielding HS fragments of still appreciable size ( approximately 5-7 kDa).	Heparitin Sulfate	63-78	glucuronidase beta	Homo sapiens	22-42
17041566-1	2007	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains at a limited number of sites, yielding HS fragments of still appreciable size ( approximately 5-7 kDa).	Heparitin Sulfate	80-82	heparanase	Homo sapiens	0-10
16919311-7	2007	In contrast to this, HS led to a strongly and CS to a slightly decreased TFPI-mRNA expression.	Heparitin Sulfate	21-23	tissue factor pathway inhibitor	Homo sapiens	73-77
16905191-6	2007	KCP additionally enhances virion binding to permissive cells through a heparin/heparan sulfate-binding site located at the N-terminus of the protein.	Heparitin Sulfate	79-94	kielin cysteine rich BMP regulator	Homo sapiens	0-3
17259344-5	2007	SDF-1 associates with CXCR4, and syndecan-4 (SDC-4), a heparan sulfate proteoglycan at the plasma membrane of Huh7 cells, induces the growth of Huh7 cells by promoting their entry into the cell cycle, and inhibits the tumor necrosis factor-alpha-mediated apoptosis of the cells.	Heparitin Sulfate	55-70	C-X-C motif chemokine ligand 12	Homo sapiens	0-5
17259344-5	2007	SDF-1 associates with CXCR4, and syndecan-4 (SDC-4), a heparan sulfate proteoglycan at the plasma membrane of Huh7 cells, induces the growth of Huh7 cells by promoting their entry into the cell cycle, and inhibits the tumor necrosis factor-alpha-mediated apoptosis of the cells.	Heparitin Sulfate	55-70	syndecan 4	Homo sapiens	33-43
17259344-5	2007	SDF-1 associates with CXCR4, and syndecan-4 (SDC-4), a heparan sulfate proteoglycan at the plasma membrane of Huh7 cells, induces the growth of Huh7 cells by promoting their entry into the cell cycle, and inhibits the tumor necrosis factor-alpha-mediated apoptosis of the cells.	Heparitin Sulfate	55-70	syndecan 4	Homo sapiens	45-50
17259344-5	2007	SDF-1 associates with CXCR4, and syndecan-4 (SDC-4), a heparan sulfate proteoglycan at the plasma membrane of Huh7 cells, induces the growth of Huh7 cells by promoting their entry into the cell cycle, and inhibits the tumor necrosis factor-alpha-mediated apoptosis of the cells.	Heparitin Sulfate	55-70	MIR7-3 host gene	Homo sapiens	110-114
17259344-5	2007	SDF-1 associates with CXCR4, and syndecan-4 (SDC-4), a heparan sulfate proteoglycan at the plasma membrane of Huh7 cells, induces the growth of Huh7 cells by promoting their entry into the cell cycle, and inhibits the tumor necrosis factor-alpha-mediated apoptosis of the cells.	Heparitin Sulfate	55-70	MIR7-3 host gene	Homo sapiens	144-148
17217623-1	2006	Heparanase is an endoglycosidase that specifically cleaves heparan sulfate (HS) side chains of HS proteoglycans, the major proteoglycans in the extracellular matrix and cell surfaces.	Heparitin Sulfate	59-74	heparanase	Homo sapiens	0-10
18023704-1	2007	Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence participates in degradation and remodeling of the extracellular matrix (ECM).	Heparitin Sulfate	47-62	heparanase	Homo sapiens	0-10
18023704-1	2007	Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence participates in degradation and remodeling of the extracellular matrix (ECM).	Heparitin Sulfate	64-66	heparanase	Homo sapiens	0-10
18023704-12	2007	These and other results indicate that pro-heparanase is rapidly tethered on cell surfaces, partially depending on cell surface heparan sulfate, generating a local procoagulant effect.	Heparitin Sulfate	127-142	heparanase	Homo sapiens	42-52
17142766-7	2006	Surface plasmon resonance studies revealed that HNPs 1, 2, 3, and HD5 bound HSV glycoprotein B (gB) with high affinity, but showed minimal binding to heparan sulfate, the receptor for attachment.	Heparitin Sulfate	150-165	defensin alpha 5	Homo sapiens	66-69
17142766-8	2006	In contrast, HNP-4 and HD6 bound heparan sulfate, but not gB.	Heparitin Sulfate	33-48	defensin alpha 4	Homo sapiens	13-18
17142766-8	2006	In contrast, HNP-4 and HD6 bound heparan sulfate, but not gB.	Heparitin Sulfate	33-48	defensin alpha 6	Homo sapiens	23-26
17142766-9	2006	HBD3 bound both gB and heparan sulfate, but hBD1 and hBD2 bound neither.	Heparitin Sulfate	23-38	defensin beta 103B	Homo sapiens	0-4
17142960-6	2006	During the rolling interaction, which is mediated by L-selectin and sulfated glycans, lymphocytes receive activation signals from chemokines presented on the surface of HEV by heparan sulfate, a sulfated glycosaminoglycan, which leads to the activation of lymphocyte beta2 integrin.	Heparitin Sulfate	176-191	selectin, lymphocyte	Mus musculus	53-63
17142960-6	2006	During the rolling interaction, which is mediated by L-selectin and sulfated glycans, lymphocytes receive activation signals from chemokines presented on the surface of HEV by heparan sulfate, a sulfated glycosaminoglycan, which leads to the activation of lymphocyte beta2 integrin.	Heparitin Sulfate	176-191	hemoglobin, beta adult minor chain	Mus musculus	267-272
17107998-0	2006	Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.	Heparitin Sulfate	0-15	N-deacetylase and N-sulfotransferase 1	Homo sapiens	34-39
17107998-4	2006	In this study, we demonstrate that inactivation of the heparan sulfate biosynthetic gene Ndst1 resulted in invagination defects of the early lens and in the disruption of lens-determination gene expression, leading to severe lens hypoplasia or anophthalmia.	Heparitin Sulfate	55-70	N-deacetylase and N-sulfotransferase 1	Homo sapiens	89-94
17107998-5	2006	Ndst1 mutants exhibited reduced sulfation of heparan sulfate, but both BMP- and Wnt-signaling remained unchanged.	Heparitin Sulfate	45-60	N-deacetylase and N-sulfotransferase 1	Homo sapiens	0-5
16895523-5	2006	Detection in purified virus preparations of a neo-epitope generated by heparinase III confirmed the presence of virus-associated HSPG [HS (heparan sulfate) proteoglycan], acquired from the producer cell.	Heparitin Sulfate	139-154	syndecan 2	Mus musculus	129-133
17055473-3	2006	It has been generally assumed that Dally affects signaling by directly interacting with these growth factors, primarily through its heparan sulfate (HS) chains.	Heparitin Sulfate	132-147	division abnormally delayed	Drosophila melanogaster	35-40
17055473-3	2006	It has been generally assumed that Dally affects signaling by directly interacting with these growth factors, primarily through its heparan sulfate (HS) chains.	Heparitin Sulfate	149-151	division abnormally delayed	Drosophila melanogaster	35-40
17055473-9	2006	These data reveal that heparan sulfate modification of Dally is not required for all in vivo activities and that significant functional capacity resides in the protein core.	Heparitin Sulfate	23-38	division abnormally delayed	Drosophila melanogaster	55-60
17040907-0	2006	Antiangiogenic antithrombin blocks the heparan sulfate-dependent binding of proangiogenic growth factors to their endothelial cell receptors: evidence for differential binding of antiangiogenic and anticoagulant forms of antithrombin to proangiogenic heparan sulfate domains.	Heparitin Sulfate	39-54	serpin family C member 1	Homo sapiens	15-27
17040907-0	2006	Antiangiogenic antithrombin blocks the heparan sulfate-dependent binding of proangiogenic growth factors to their endothelial cell receptors: evidence for differential binding of antiangiogenic and anticoagulant forms of antithrombin to proangiogenic heparan sulfate domains.	Heparitin Sulfate	39-54	serpin family C member 1	Homo sapiens	221-233
17040907-0	2006	Antiangiogenic antithrombin blocks the heparan sulfate-dependent binding of proangiogenic growth factors to their endothelial cell receptors: evidence for differential binding of antiangiogenic and anticoagulant forms of antithrombin to proangiogenic heparan sulfate domains.	Heparitin Sulfate	251-266	serpin family C member 1	Homo sapiens	15-27
17040907-0	2006	Antiangiogenic antithrombin blocks the heparan sulfate-dependent binding of proangiogenic growth factors to their endothelial cell receptors: evidence for differential binding of antiangiogenic and anticoagulant forms of antithrombin to proangiogenic heparan sulfate domains.	Heparitin Sulfate	251-266	serpin family C member 1	Homo sapiens	221-233
17040907-8	2006	Moreover, the inability of native antithrombin to bind this co-receptor implies that native and conformationally altered forms of antithrombin differentially bind proangiogenic heparan sulfate domains.	Heparitin Sulfate	177-192	serpin family C member 1	Homo sapiens	130-142
16971378-0	2006	Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes.	Heparitin Sulfate	60-75	glypican 1	Homo sapiens	91-101
16971378-1	2006	The recycling heparan sulfate (HS)-containing proteoglycan glypican-1 (Gpc-1) is processed by nitric oxide (NO)-catalyzed deaminative cleavage of its HS chains at N-unsubstituted glucosamines.	Heparitin Sulfate	14-29	glypican 1	Homo sapiens	59-69
16971378-1	2006	The recycling heparan sulfate (HS)-containing proteoglycan glypican-1 (Gpc-1) is processed by nitric oxide (NO)-catalyzed deaminative cleavage of its HS chains at N-unsubstituted glucosamines.	Heparitin Sulfate	14-29	glypican 1	Homo sapiens	71-76
16971378-1	2006	The recycling heparan sulfate (HS)-containing proteoglycan glypican-1 (Gpc-1) is processed by nitric oxide (NO)-catalyzed deaminative cleavage of its HS chains at N-unsubstituted glucosamines.	Heparitin Sulfate	31-33	glypican 1	Homo sapiens	59-69
16971378-1	2006	The recycling heparan sulfate (HS)-containing proteoglycan glypican-1 (Gpc-1) is processed by nitric oxide (NO)-catalyzed deaminative cleavage of its HS chains at N-unsubstituted glucosamines.	Heparitin Sulfate	31-33	glypican 1	Homo sapiens	71-76
16971378-7	2006	When NO-catalyzed degradation of HS was depressed in mouse neuroblastoma cell line (N2a) by using 3-beta[2(diethylamino) ethoxy]androst-5-en-17-one (U18666A), both ascorbate and dehydroascorbic acid restored formation of anMan-positive products that colocalized with Rab7.	Heparitin Sulfate	33-35	RAB7, member RAS oncogene family	Mus musculus	267-271
17217623-1	2006	Heparanase is an endoglycosidase that specifically cleaves heparan sulfate (HS) side chains of HS proteoglycans, the major proteoglycans in the extracellular matrix and cell surfaces.	Heparitin Sulfate	76-78	heparanase	Homo sapiens	0-10
16901266-9	2006	Mitogenesis assays with FGF2 (fibroblast growth factor 2) revealed that Sulf activity decreases the activating potential of newly-synthesized HS, suggesting an important role for these enzymes in cell growth regulation in embryonic and adult tissues.	Heparitin Sulfate	142-144	fibroblast growth factor 2	Mus musculus	24-28
17068295-7	2006	Competition and direct binding assays indicate that the strong interaction of ANGPTL4 with the ECM is heparin/heparan sulfate proteoglycan dependent.	Heparitin Sulfate	110-125	angiopoietin like 4	Homo sapiens	78-85
16901266-9	2006	Mitogenesis assays with FGF2 (fibroblast growth factor 2) revealed that Sulf activity decreases the activating potential of newly-synthesized HS, suggesting an important role for these enzymes in cell growth regulation in embryonic and adult tissues.	Heparitin Sulfate	142-144	fibroblast growth factor 2	Mus musculus	30-56
17079438-2	2006	The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are up-regulated in breast cancer, generating a microenvironment that promotes tumor progression and metastasis.	Heparitin Sulfate	4-19	CD44 molecule (Indian blood group)	Homo sapiens	78-82
17073444-1	2006	Heparan sulfate (HS) recognizes a variety of proteins, one of which is the pleiotropic cytokine IFN-gamma, and as such modulates many biological processes.	Heparitin Sulfate	0-15	interferon gamma	Homo sapiens	96-105
17073444-1	2006	Heparan sulfate (HS) recognizes a variety of proteins, one of which is the pleiotropic cytokine IFN-gamma, and as such modulates many biological processes.	Heparitin Sulfate	17-19	interferon gamma	Homo sapiens	96-105
17073444-2	2006	IFN-gamma is a homodimer with a well-defined core and two flexible C-termini that constitute HS binding domains.	Heparitin Sulfate	93-95	interferon gamma	Homo sapiens	0-9
17073444-4	2006	Since a 21-24-disaccharide HS fragment was experimentally defined as the minimum size that interacts with IFN-gamma [Lortat-Jacob, H., Turnbull, J. E., and Grimaud, J.	Heparitin Sulfate	27-29	interferon gamma	Homo sapiens	106-115
16985521-8	2006	Treatment of MC with heparanase removed PTN from the cells suggesting that its localization was owing to an association with heparan sulfates on the cell surface or in the extracellular matrix.	Heparitin Sulfate	125-141	pleiotrophin	Homo sapiens	40-43
16970801-2	2006	Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate chains on cell surfaces and in the extracellular matrix, activity that closely correlates with cell invasion, angiogenesis and tumor metastasis.	Heparitin Sulfate	56-71	heparanase	Homo sapiens	0-10
16970801-2	2006	Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate chains on cell surfaces and in the extracellular matrix, activity that closely correlates with cell invasion, angiogenesis and tumor metastasis.	Heparitin Sulfate	56-71	glucuronidase beta	Homo sapiens	22-42
17016645-1	2006	Glypican1 (GPC1) is a cell surface heparan sulfate proteoglycan that acts as a co-receptor for heparin-binding growth factors as well as for members of the TGF-beta family.	Heparitin Sulfate	35-50	glypican 1	Homo sapiens	0-9
17016645-1	2006	Glypican1 (GPC1) is a cell surface heparan sulfate proteoglycan that acts as a co-receptor for heparin-binding growth factors as well as for members of the TGF-beta family.	Heparitin Sulfate	35-50	glypican 1	Homo sapiens	11-15
16940047-4	2006	Using flow cytometry and site-directed mutagenesis, we demonstrate here that the MBP domain of pro-MBP binds to heparan sulfate GAG on the cell surface and that this is independent of GAG covalently bound to pro-MBP.	Heparitin Sulfate	112-127	myelin basic protein	Homo sapiens	81-84
16989989-3	2006	Growth factors such as fibroblast growth factors (FGFs) bind cell surface heparan sulfate proteoglycans (HSPGs) on their heparan sulfate side chains and as such these proteoglycans act as co-receptors for FGF receptors (FGFRs) by forming a ternary signaling complex of HSPG, FGFR and FGF.	Heparitin Sulfate	74-89	syndecan 2	Mus musculus	105-109
17076889-12	2006	In addition, we also studied the expression patterns of two genes with similarity to Drosophila frizzled, T23D8.1 and F27E11.3A, and the ortholog of the Drosophila gene dally-like, gpn-1, which is a heparan sulfate proteoglycan.	Heparitin Sulfate	199-214	GlyPicaN	Caenorhabditis elegans	181-186
16940047-4	2006	Using flow cytometry and site-directed mutagenesis, we demonstrate here that the MBP domain of pro-MBP binds to heparan sulfate GAG on the cell surface and that this is independent of GAG covalently bound to pro-MBP.	Heparitin Sulfate	112-127	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	95-102
16873373-8	2006	These results indicate that dPAPST2 may be involved in Hedgehog and Decapentaplegic signaling by controlling the sulfation of heparan sulfate.	Heparitin Sulfate	126-141	PAPS transporter 2	Drosophila melanogaster	28-35
17004727-1	2006	Heparan sulfate (HS) regulates processing of the amyloid precursor protein by the Alzheimer"s beta-secretase (BACE-1).	Heparitin Sulfate	0-15	beta-secretase 1	Homo sapiens	110-116
17004727-1	2006	Heparan sulfate (HS) regulates processing of the amyloid precursor protein by the Alzheimer"s beta-secretase (BACE-1).	Heparitin Sulfate	17-19	beta-secretase 1	Homo sapiens	110-116
16778156-12	2006	In conclusion, we could show that key enzymes for CS, DS, and HS synthesis, especially XT-I, are useful markers for the developmental stages of chondrogenic differentiation.	Heparitin Sulfate	62-64	xylosyltransferase 1	Homo sapiens	87-91
17034626-5	2006	We present a structure-function analysis of the different DmKal-1 domains, including a predicted heparan-sulfate binding site.	Heparitin Sulfate	97-112	Kallmann syndrome 1	Drosophila melanogaster	58-65
16793191-4	2006	In addition to the increase in the core protein, a parallel increase in the glycosylation of the syndecan-4 protein, a proteoglycan that bears heparan sulfate chains, also occurs.	Heparitin Sulfate	143-158	syndecan-4	Oryctolagus cuniculus	97-107
16793191-6	2006	This enhancement in heparan sulfate synthesis was observed through metabolic labeling of the cells, immunoprecipitation of syndecan-4 and heparitinases treatment.	Heparitin Sulfate	20-35	syndecan-4	Oryctolagus cuniculus	123-133
16793191-10	2006	Decreases in the mRNA levels of some enzymes (glucuronosyl C-5 epimerase, iduronosyl-2-O-sulfotransferase, glucosaminyl-6-O-sulfotransferase-1 and N-deacetylase/N-sulfotransferase-1), involved in the biosynthetic pathway of heparan sulfate, were also observed.	Heparitin Sulfate	224-239	bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1	Oryctolagus cuniculus	107-181
16862076-6	2006	Stromal 10E4 expression was significantly associated with tumor grade, stromal p53, and MIB1 expression in proliferating cells, suggesting that heparan sulfate may participate in malignant tumor growth.	Heparitin Sulfate	144-159	MIB E3 ubiquitin protein ligase 1	Homo sapiens	88-92
16972797-1	2006	Recently a novel plasma serine protease with high affinity to hyaluronic acid and glycosaminoglycans, such as heparin and heparan sulfate, has been described and termed hyaluronan-binding protease (HABP).	Heparitin Sulfate	122-137	hyaluronan binding protein 2	Homo sapiens	169-196
16829530-1	2006	The regulation of cell function by fibroblast growth factors (FGF) occurs through a dual receptor system consisting of a receptor-tyrosine kinase, FGFR and the glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	178-193	fibroblast growth factor 2	Homo sapiens	62-65
16829530-1	2006	The regulation of cell function by fibroblast growth factors (FGF) occurs through a dual receptor system consisting of a receptor-tyrosine kinase, FGFR and the glycosaminoglycan heparan sulfate (HS).	Heparitin Sulfate	195-197	fibroblast growth factor 2	Homo sapiens	62-65
16966419-0	2006	Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling.	Heparitin Sulfate	31-46	branchless	Drosophila melanogaster	75-78
16982797-1	2006	Cell surface heparan sulfate (HS) proteoglycans are carbohydrate-rich regulators of cell migratory, mitogenic, secretory, and inflammatory activity that bind and present soluble heparin-binding growth factors (e.g., fibroblast growth factor, Wnt, Hh, transforming growth factor beta, amphiregulin, and hepatocyte growth factor) to their respective signaling receptors.	Heparitin Sulfate	13-28	amphiregulin	Homo sapiens	284-296
16982797-1	2006	Cell surface heparan sulfate (HS) proteoglycans are carbohydrate-rich regulators of cell migratory, mitogenic, secretory, and inflammatory activity that bind and present soluble heparin-binding growth factors (e.g., fibroblast growth factor, Wnt, Hh, transforming growth factor beta, amphiregulin, and hepatocyte growth factor) to their respective signaling receptors.	Heparitin Sulfate	30-32	amphiregulin	Homo sapiens	284-296
16784821-0	2006	Nerve injury induces the expression of EXT2, a glycosyltransferase required for heparan sulfate synthesis.	Heparitin Sulfate	80-95	exostosin glycosyltransferase 2	Homo sapiens	39-43
16784821-3	2006	Here, we found that the mRNA expression of EXT2, one of the crucial enzymes for heparan sulfate-glycosaminoglycan synthesis, was markedly up-regulated in injured hypoglossal motor neurons after axotomy.	Heparitin Sulfate	80-95	exostosin glycosyltransferase 2	Homo sapiens	43-47
16784821-5	2006	Furthermore, the mRNA expressions of glypican-1 and syndecan-1, which are both well-known heparan sulfate proteoglycans, were prominently up-regulated in injured motor neurons.	Heparitin Sulfate	90-105	glypican 1	Homo sapiens	37-47
16784821-5	2006	Furthermore, the mRNA expressions of glypican-1 and syndecan-1, which are both well-known heparan sulfate proteoglycans, were prominently up-regulated in injured motor neurons.	Heparitin Sulfate	90-105	syndecan 1	Homo sapiens	52-62
16784821-6	2006	These results suggest that the biosynthesis of heparan sulfate chains promoted by EXT2 is activated in injured motor neurons, and that glypican-1 and syndecan-1 are potent candidates for heparan sulfate proteoglycans involved in peripheral nerve regeneration.	Heparitin Sulfate	47-62	exostosin glycosyltransferase 2	Homo sapiens	82-86
16972797-1	2006	Recently a novel plasma serine protease with high affinity to hyaluronic acid and glycosaminoglycans, such as heparin and heparan sulfate, has been described and termed hyaluronan-binding protease (HABP).	Heparitin Sulfate	122-137	hyaluronan binding protein 2	Homo sapiens	198-202
16909199-0	2006	A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2.	Heparitin Sulfate	38-53	kinase insert domain receptor	Homo sapiens	114-121
16413747-1	2006	Betaglycan, a cell surface heparan sulphate proteoglycan, is traditionally thought to function by binding transforming growth factor type beta (TGF-beta) via its core protein and then transferring the growth factor to its signaling receptor, the type II receptor.	Heparitin Sulfate	27-43	transforming growth factor beta receptor 3	Homo sapiens	0-10
16413747-1	2006	Betaglycan, a cell surface heparan sulphate proteoglycan, is traditionally thought to function by binding transforming growth factor type beta (TGF-beta) via its core protein and then transferring the growth factor to its signaling receptor, the type II receptor.	Heparitin Sulfate	27-43	transforming growth factor beta 1	Homo sapiens	144-152
16909199-0	2006	A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2.	Heparitin Sulfate	38-53	vascular endothelial growth factor A	Homo sapiens	2-8
16909199-7	2006	VEGF-A(165)b weakly binds to heparan sulfate and does not interact with neuropilin-1, a coreceptor for VEGF receptor 2.	Heparitin Sulfate	29-44	vascular endothelial growth factor A	Homo sapiens	0-6
17080204-0	2006	The role of heparan sulfate in the generation of Abeta.	Heparitin Sulfate	12-27	amyloid beta precursor protein	Homo sapiens	49-54
16951194-6	2006	In addition, JG3 abolished heparanase-driven invasion, inhibited the release of heparan sulfate-sequestered basic fibroblast growth factor (bFGF) from the extracellular matrix, and repressed subsequent angiogenesis.	Heparitin Sulfate	80-95	fibroblast growth factor 2	Homo sapiens	108-138
16951194-6	2006	In addition, JG3 abolished heparanase-driven invasion, inhibited the release of heparan sulfate-sequestered basic fibroblast growth factor (bFGF) from the extracellular matrix, and repressed subsequent angiogenesis.	Heparitin Sulfate	80-95	fibroblast growth factor 2	Homo sapiens	140-144
17080204-2	2006	Heparan sulfate, a heterogeneously sulfated glycosaminoglycan, has been identified as the first naturally occurring inhibitor of beta secretase, the rate-limiting step in the formation of Abeta, the peptide core of the amyloid plaques that cause Alzheimer"s disease.	Heparitin Sulfate	0-15	amyloid beta precursor protein	Homo sapiens	188-193
16940509-5	2006	Reverse transcription-PCR analysis indicated expression of herpesvirus entry mediator and 3-O-sulfated (3-OS) heparan sulfate (HS)-generating enzyme 3-O sulfotransferase 3 (3-OST-3) but not nectin-1 or nectin-2.	Heparitin Sulfate	110-125	nectin cell adhesion molecule 1	Homo sapiens	190-198
16940509-5	2006	Reverse transcription-PCR analysis indicated expression of herpesvirus entry mediator and 3-O-sulfated (3-OS) heparan sulfate (HS)-generating enzyme 3-O sulfotransferase 3 (3-OST-3) but not nectin-1 or nectin-2.	Heparitin Sulfate	127-129	nectin cell adhesion molecule 1	Homo sapiens	190-198
16754680-3	2006	Here we show that PDCD5 has a remarkable role in intercellular transport in various cells (endogenous caveolin-1-positive and -negative cells) through a clathrin-independent endocytic pathway that originates from heparan sulfate proteoglycan binding and lipid rafts.	Heparitin Sulfate	213-228	programmed cell death 5	Homo sapiens	18-23
16922507-6	2006	Treatment of the complex endothelial extracellular matrix with heparin also increased VEGF binding, suggesting that heparin/heparan sulfate might regulate VEGF interactions within the extracellular matrix by controlling the structure and organization of fibronectin matrices.	Heparitin Sulfate	124-139	vascular endothelial growth factor A	Homo sapiens	86-90
16922507-6	2006	Treatment of the complex endothelial extracellular matrix with heparin also increased VEGF binding, suggesting that heparin/heparan sulfate might regulate VEGF interactions within the extracellular matrix by controlling the structure and organization of fibronectin matrices.	Heparitin Sulfate	124-139	vascular endothelial growth factor A	Homo sapiens	155-159
16922507-6	2006	Treatment of the complex endothelial extracellular matrix with heparin also increased VEGF binding, suggesting that heparin/heparan sulfate might regulate VEGF interactions within the extracellular matrix by controlling the structure and organization of fibronectin matrices.	Heparitin Sulfate	124-139	fibronectin 1	Homo sapiens	254-265
16782967-0	2006	Isolation and characterization of low sulfated heparan sulfate sequences with affinity for lipoprotein lipase.	Heparitin Sulfate	47-62	lipoprotein lipase	Homo sapiens	91-109
16782967-1	2006	Lipoprotein lipase (LPL), which is an important enzyme in lipid metabolism, binds to heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	85-100	lipoprotein lipase	Homo sapiens	0-18
16782967-1	2006	Lipoprotein lipase (LPL), which is an important enzyme in lipid metabolism, binds to heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	85-100	lipoprotein lipase	Homo sapiens	20-23
16782967-1	2006	Lipoprotein lipase (LPL), which is an important enzyme in lipid metabolism, binds to heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	102-104	lipoprotein lipase	Homo sapiens	0-18
16782967-1	2006	Lipoprotein lipase (LPL), which is an important enzyme in lipid metabolism, binds to heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	102-104	lipoprotein lipase	Homo sapiens	20-23
16782967-4	2006	Earlier studies have demonstrated that LPL interacts with highly sulfated HS and heparin oligosaccharides.	Heparitin Sulfate	74-76	lipoprotein lipase	Homo sapiens	39-42
16828069-3	2006	The B6.Cg-Sgsh(mps3a) strain compares favorably with the original mixed donor strain, exhibiting low liver sulfamidase activity and significant brain heparan sulfate-derived disaccharide elevation from birth.	Heparitin Sulfate	150-165	N-sulfoglucosamine sulfohydrolase	Homo sapiens	10-14
16828054-5	2006	GAGs from different structure/origin (heparan sulfate, dermatan sulfate, and chondroitin sulfate) exert similar activity on OPG binding.	Heparitin Sulfate	38-53	TNF receptor superfamily member 11b	Homo sapiens	124-127
16828054-10	2006	These data support an essential function of the related glycosaminoglycans heparin and heparan sulfate in the activity of the triad RANK-RANKL-OPG.	Heparitin Sulfate	87-102	TNF superfamily member 11	Homo sapiens	137-142
16828054-10	2006	These data support an essential function of the related glycosaminoglycans heparin and heparan sulfate in the activity of the triad RANK-RANKL-OPG.	Heparitin Sulfate	87-102	TNF receptor superfamily member 11b	Homo sapiens	143-146
16828069-3	2006	The B6.Cg-Sgsh(mps3a) strain compares favorably with the original mixed donor strain, exhibiting low liver sulfamidase activity and significant brain heparan sulfate-derived disaccharide elevation from birth.	Heparitin Sulfate	150-165	N-sulfoglucosamine sulfohydrolase	Homo sapiens	15-20
16807373-1	2006	The importance of heparan- and chondroitin-sulfate proteoglycans in physiological and pathological processes led to the investigation of the regulation of beta1,3-glucuronosyltransferase I (GlcAT-I), responsible for the completion of glycosaminoglycan-protein linkage tetrasaccharide, a key step prior to polymerization of chondroitin- and heparan-sulfate chains.	Heparitin Sulfate	340-355	beta-1,3-glucuronyltransferase 3	Homo sapiens	190-197
16880403-7	2006	The scattering data also highlighted a very compact, globular region of the fibrillin-1 molecule, which contains the integrin and heparan sulfate-binding sites.	Heparitin Sulfate	130-145	fibrillin 1	Homo sapiens	76-87
16778174-6	2006	More importantly, HSulf-1 expression in the xenografts was associated with a reduced ability of vascular endothelial cell heparan sulfate to participate in a complex with fibroblast growth factor 2 (FGF-2) and its receptor tyrosine kinase FGF receptor 1c.	Heparitin Sulfate	122-137	fibroblast growth factor 2	Homo sapiens	199-204
16645004-0	2006	Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts.	Heparitin Sulfate	69-84	glypican 1	Homo sapiens	58-68
16728399-5	2006	Here we show that when endogenous HS was inhibited by chlorate treatment, 7,8-S-OctaF7 specifically supported FGF7-stimulated DNA synthesis and downstream signaling in FGFR2IIIb-expressing mouse keratinocytes.	Heparitin Sulfate	34-36	fibroblast growth factor 7	Mus musculus	110-114
16622899-7	2006	EXT is involved in heparan sulphate biosynthesis, important for Indian Hedgehog/ParaThyroid Hormone Like Hormone (IHH/PTHLH) growth plate signalling pathways.	Heparitin Sulfate	19-35	exostosin glycosyltransferase 1	Homo sapiens	0-3
16622899-7	2006	EXT is involved in heparan sulphate biosynthesis, important for Indian Hedgehog/ParaThyroid Hormone Like Hormone (IHH/PTHLH) growth plate signalling pathways.	Heparitin Sulfate	19-35	parathyroid hormone like hormone	Homo sapiens	80-112
16622899-7	2006	EXT is involved in heparan sulphate biosynthesis, important for Indian Hedgehog/ParaThyroid Hormone Like Hormone (IHH/PTHLH) growth plate signalling pathways.	Heparitin Sulfate	19-35	parathyroid hormone like hormone	Homo sapiens	118-123
16823965-5	2006	The specificity of the receptor-ligand interaction was confirmed by the lack of cell binding to the negative control proteins, cytochrome c and insulin, and by the disruption of cell binding by treatment with heparitinase to destroy heparan sulfate which plays an essential role in the binding of bFGF to FGF receptors.	Heparitin Sulfate	233-248	fibroblast growth factor 2	Homo sapiens	297-301
16823965-5	2006	The specificity of the receptor-ligand interaction was confirmed by the lack of cell binding to the negative control proteins, cytochrome c and insulin, and by the disruption of cell binding by treatment with heparitinase to destroy heparan sulfate which plays an essential role in the binding of bFGF to FGF receptors.	Heparitin Sulfate	233-248	fibroblast growth factor 2	Homo sapiens	298-301
16867222-3	2006	HPSE enzymatically cleaves heparan sulfate glycosaminoglycan chains (HS) from proteoglycans.	Heparitin Sulfate	27-42	heparanase	Homo sapiens	0-4
16677626-4	2006	Defects in heparan sulfate (HS) synthesis or in specific HS modifications disrupt neuroblast migrations and affect the KAL-1 pathway.	Heparitin Sulfate	11-26	uncharacterized protein	Caenorhabditis elegans	119-124
16645004-3	2006	During recycling through intracellular compartments, the heparan sulfate (HS) side chains of Gpc-1 are deaminatively degraded by nitric oxide (NO) derived from preformed S-nitroso groups in the core protein.	Heparitin Sulfate	57-72	glypican 1	Homo sapiens	93-98
16645004-3	2006	During recycling through intracellular compartments, the heparan sulfate (HS) side chains of Gpc-1 are deaminatively degraded by nitric oxide (NO) derived from preformed S-nitroso groups in the core protein.	Heparitin Sulfate	74-76	glypican 1	Homo sapiens	93-98
16778174-6	2006	More importantly, HSulf-1 expression in the xenografts was associated with a reduced ability of vascular endothelial cell heparan sulfate to participate in a complex with fibroblast growth factor 2 (FGF-2) and its receptor tyrosine kinase FGF receptor 1c.	Heparitin Sulfate	122-137	fibroblast growth factor 2	Homo sapiens	171-197
16778174-7	2006	In vitro, short hairpin RNA-mediated down-regulation of HSulf-1 in human umbilical vein endothelial cells (HUVEC) resulted in an increased proliferation mediated by heparan sulfate-dependent FGF-2, hepatocyte growth factor, and vascular endothelial growth factor 165 (VEGF165) but not by heparan sulfate-independent VEGF121.	Heparitin Sulfate	165-180	fibroblast growth factor 2	Homo sapiens	191-196
16709175-5	2006	Thus the presence of heparin increases the potency of HGF/SF in experiments with cells in culture leading to elevated downstream signalling effects and, although not vital for the Met-HGF/SF interaction, heparin or heparan sulphate is essential for the activity of certain isoforms of HGF/SF, such as NK1 and NK2.	Heparitin Sulfate	215-231	tachykinin receptor 1	Homo sapiens	301-304
16734417-0	2006	Artemin crystal structure reveals insights into heparan sulfate binding.	Heparitin Sulfate	48-63	artemin	Homo sapiens	0-7
16709175-3	2006	HGF/SF, like many other angiogenic growth factors, employs heparan sulphate as co-receptor.	Heparitin Sulfate	59-75	hepatocyte growth factor	Homo sapiens	0-6
16709175-5	2006	Thus the presence of heparin increases the potency of HGF/SF in experiments with cells in culture leading to elevated downstream signalling effects and, although not vital for the Met-HGF/SF interaction, heparin or heparan sulphate is essential for the activity of certain isoforms of HGF/SF, such as NK1 and NK2.	Heparitin Sulfate	215-231	NK2 homeobox 1	Homo sapiens	309-312
16709175-5	2006	Thus the presence of heparin increases the potency of HGF/SF in experiments with cells in culture leading to elevated downstream signalling effects and, although not vital for the Met-HGF/SF interaction, heparin or heparan sulphate is essential for the activity of certain isoforms of HGF/SF, such as NK1 and NK2.	Heparitin Sulfate	215-231	hepatocyte growth factor	Homo sapiens	54-60
16709175-6	2006	Here, we summarize the progress made in understanding the interaction between heparin and heparan sulphate and NK1, NK2 and HGF/SF and we discuss their role in HGF/SF-Met signalling.	Heparitin Sulfate	90-106	hepatocyte growth factor	Homo sapiens	124-130
16709187-6	2006	In studies in my laboratory, we have shown that GDNF (glial-cell-line-derived neurotrophic factor) and its close relatives neurturin and artemin bind to heparin and heparan sulphate with high affinity.	Heparitin Sulfate	165-181	glial cell derived neurotrophic factor	Homo sapiens	48-52
16709187-6	2006	In studies in my laboratory, we have shown that GDNF (glial-cell-line-derived neurotrophic factor) and its close relatives neurturin and artemin bind to heparin and heparan sulphate with high affinity.	Heparitin Sulfate	165-181	glial cell derived neurotrophic factor	Homo sapiens	54-97
16709187-8	2006	More recently, we and others have been investigating the heparin/heparan sulphate-binding properties of BMP-7, which is a representative of a distinct BMP subgroup from that of BMPs -2 and -4.	Heparitin Sulfate	65-81	bone morphogenetic protein 7	Homo sapiens	104-109
16709187-8	2006	More recently, we and others have been investigating the heparin/heparan sulphate-binding properties of BMP-7, which is a representative of a distinct BMP subgroup from that of BMPs -2 and -4.	Heparitin Sulfate	65-81	bone morphogenetic protein 2	Homo sapiens	104-107
16709188-4	2006	IFNgamma, the sole type II IFN, is structurally unrelated, binds to a different receptor and, as a dimer, strongly interacts with HS (heparan sulphate).	Heparitin Sulfate	130-132	interferon gamma	Homo sapiens	0-8
16709188-4	2006	IFNgamma, the sole type II IFN, is structurally unrelated, binds to a different receptor and, as a dimer, strongly interacts with HS (heparan sulphate).	Heparitin Sulfate	130-132	interferon alpha 1	Homo sapiens	0-3
16709188-4	2006	IFNgamma, the sole type II IFN, is structurally unrelated, binds to a different receptor and, as a dimer, strongly interacts with HS (heparan sulphate).	Heparitin Sulfate	134-150	interferon gamma	Homo sapiens	0-8
16709188-4	2006	IFNgamma, the sole type II IFN, is structurally unrelated, binds to a different receptor and, as a dimer, strongly interacts with HS (heparan sulphate).	Heparitin Sulfate	134-150	interferon alpha 1	Homo sapiens	0-3
16709188-6	2006	IFNgamma binding to HS controls the blood clearance, the subsequent tissue targeting and the local accumulation of the cytokine.	Heparitin Sulfate	20-22	interferon gamma	Homo sapiens	0-8
16514606-11	2006	Collectively, our data suggest that proteoglycans tonically suppress osteoblast function and that this inhibition is alleviated by HS degradation with heparanase.	Heparitin Sulfate	131-133	heparanase	Mus musculus	151-161
16759289-0	2006	Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparan sulfate cleavage.	Heparitin Sulfate	95-110	heparanase	Homo sapiens	0-10
16759289-1	2006	Heparanase is an endo-beta-glucuronidase that specifically cleaves heparan sulfate (HS) chains.	Heparitin Sulfate	67-82	heparanase	Homo sapiens	0-10
16759289-1	2006	Heparanase is an endo-beta-glucuronidase that specifically cleaves heparan sulfate (HS) chains.	Heparitin Sulfate	67-82	glucuronidase beta	Homo sapiens	22-40
16759289-1	2006	Heparanase is an endo-beta-glucuronidase that specifically cleaves heparan sulfate (HS) chains.	Heparitin Sulfate	84-86	heparanase	Homo sapiens	0-10
16759289-1	2006	Heparanase is an endo-beta-glucuronidase that specifically cleaves heparan sulfate (HS) chains.	Heparitin Sulfate	84-86	glucuronidase beta	Homo sapiens	22-40
16759289-2	2006	Heparanase is involved in the process of metastasis and angiogenesis through the degradation of HS chains of the extracellular matrix and cell surface.	Heparitin Sulfate	96-98	heparanase	Homo sapiens	0-10
16607375-1	2006	Heparanase is a mammalian endo-beta-D-glucuronidase that cleaves heparan sulfate side chains at a limited number of sites.	Heparitin Sulfate	65-80	heparanase	Homo sapiens	0-10
16705694-6	2006	Western blot showed perlecan content was greatest in the lower and upper proliferating zones and that a perlecan fragment lacking portions of the N- and C-terminal domains containing heparan sulfate was also present in all zones.	Heparitin Sulfate	183-198	heparan sulfate proteoglycan 2	Bos taurus	104-112
16357320-4	2006	TACI binding appears to require heparan sulfate posttranslational modifications of syndecan-2, because free heparin or pretreatment with heparitinase blocked the interaction.	Heparitin Sulfate	32-47	TNF receptor superfamily member 13B	Homo sapiens	0-4
16505157-6	2006	Exogenous heparan sulfate abolished the in vitro NF-kappaB inhibitory effects of the peptide.	Heparitin Sulfate	10-25	nuclear factor kappa B subunit 1	Homo sapiens	49-58
16517593-12	2006	A function of RAP may be to prevent premature interaction of LPL with binding partners in the secretory pathway, namely LRP and heparan sulfate proteoglycan.	Heparitin Sulfate	128-143	LDL receptor related protein associated protein 1	Homo sapiens	14-17
16517593-12	2006	A function of RAP may be to prevent premature interaction of LPL with binding partners in the secretory pathway, namely LRP and heparan sulfate proteoglycan.	Heparitin Sulfate	128-143	lipoprotein lipase	Homo sapiens	61-64
16669614-6	2006	In response to insulin, adipocytes are known to secrete active lipoprotein lipase, an enzyme that binds to heparan sulfate on the luminal surface of capillary endothelia.	Heparitin Sulfate	107-122	insulin	Homo sapiens	15-22
16669614-6	2006	In response to insulin, adipocytes are known to secrete active lipoprotein lipase, an enzyme that binds to heparan sulfate on the luminal surface of capillary endothelia.	Heparitin Sulfate	107-122	lipoprotein lipase	Homo sapiens	63-81
16492675-0	2006	Cellular heparan sulfate negatively modulates transforming growth factor-beta1 (TGF-beta1) responsiveness in epithelial cells.	Heparitin Sulfate	9-24	transforming growth factor beta-1 proprotein	Cricetulus griseus	46-78
16492675-0	2006	Cellular heparan sulfate negatively modulates transforming growth factor-beta1 (TGF-beta1) responsiveness in epithelial cells.	Heparitin Sulfate	9-24	transforming growth factor beta-1 proprotein	Cricetulus griseus	80-89
16492675-3	2006	Here we demonstrate that TGF-beta1 induces transcriptional activation of plasminogen activator inhibitor-1 (PAI-1) and growth inhibition more potently in CHO cell mutants deficient in heparan sulfate (CHO-677 cells) than in wild-type CHO-K1 cells.	Heparitin Sulfate	184-199	transforming growth factor beta-1 proprotein	Cricetulus griseus	25-34
16492675-3	2006	Here we demonstrate that TGF-beta1 induces transcriptional activation of plasminogen activator inhibitor-1 (PAI-1) and growth inhibition more potently in CHO cell mutants deficient in heparan sulfate (CHO-677 cells) than in wild-type CHO-K1 cells.	Heparitin Sulfate	184-199	plasminogen activator inhibitor 1	Cricetulus griseus	73-106
16492675-3	2006	Here we demonstrate that TGF-beta1 induces transcriptional activation of plasminogen activator inhibitor-1 (PAI-1) and growth inhibition more potently in CHO cell mutants deficient in heparan sulfate (CHO-677 cells) than in wild-type CHO-K1 cells.	Heparitin Sulfate	184-199	plasminogen activator inhibitor 1	Cricetulus griseus	108-113
16492675-6	2006	In Mv1Lu cells (which, like CHO-K1 cells, exhibit nystatin-inhibitable rapid degradation of receptor-bound 125I-TGF-beta1), treatment with heparitinase or a heparan sulfate biosynthesis inhibitor results in a change from a low (&lt;1) to a high (&gt;1) ratio of 125I-TGF-beta1 binding to TbetaR-II and TbetaR-I and enhanced TGF-beta1-induced transcriptional activation of PAI-1.	Heparitin Sulfate	157-172	transforming growth factor beta-1 proprotein	Cricetulus griseus	112-121
16492675-8	2006	These results suggest that heparan sulfate negatively modulates TGF-beta1 responsiveness by decreasing the ratio of TGF-beta1 binding to TbetaR-II and TbetaR-I, facilitating caveolae/lipid-raft-mediated endocytosis and rapid degradation of TGF-beta1, thus diminishing non-lipid-raft-mediated endocytosis and signaling of TGF-beta1 in these epithelial cells.	Heparitin Sulfate	27-42	transforming growth factor beta-1 proprotein	Cricetulus griseus	64-73
16492675-8	2006	These results suggest that heparan sulfate negatively modulates TGF-beta1 responsiveness by decreasing the ratio of TGF-beta1 binding to TbetaR-II and TbetaR-I, facilitating caveolae/lipid-raft-mediated endocytosis and rapid degradation of TGF-beta1, thus diminishing non-lipid-raft-mediated endocytosis and signaling of TGF-beta1 in these epithelial cells.	Heparitin Sulfate	27-42	transforming growth factor beta-1 proprotein	Cricetulus griseus	116-125
16492675-8	2006	These results suggest that heparan sulfate negatively modulates TGF-beta1 responsiveness by decreasing the ratio of TGF-beta1 binding to TbetaR-II and TbetaR-I, facilitating caveolae/lipid-raft-mediated endocytosis and rapid degradation of TGF-beta1, thus diminishing non-lipid-raft-mediated endocytosis and signaling of TGF-beta1 in these epithelial cells.	Heparitin Sulfate	27-42	transforming growth factor beta-1 proprotein	Cricetulus griseus	116-125
16492675-8	2006	These results suggest that heparan sulfate negatively modulates TGF-beta1 responsiveness by decreasing the ratio of TGF-beta1 binding to TbetaR-II and TbetaR-I, facilitating caveolae/lipid-raft-mediated endocytosis and rapid degradation of TGF-beta1, thus diminishing non-lipid-raft-mediated endocytosis and signaling of TGF-beta1 in these epithelial cells.	Heparitin Sulfate	27-42	transforming growth factor beta-1 proprotein	Cricetulus griseus	116-125
16687495-5	2006	Finally, we show that this abrupt change in Shh distribution is most likely attributable to the timely activity of Sulfatase 1 (Sulf1), a secreted enzym that modulates the sulfation state of heparan sulfate proteoglycans.	Heparitin Sulfate	191-206	sonic hedgehog	Gallus gallus	44-47
16687495-5	2006	Finally, we show that this abrupt change in Shh distribution is most likely attributable to the timely activity of Sulfatase 1 (Sulf1), a secreted enzym that modulates the sulfation state of heparan sulfate proteoglycans.	Heparitin Sulfate	191-206	sulfatase 1	Gallus gallus	115-126
16687495-5	2006	Finally, we show that this abrupt change in Shh distribution is most likely attributable to the timely activity of Sulfatase 1 (Sulf1), a secreted enzym that modulates the sulfation state of heparan sulfate proteoglycans.	Heparitin Sulfate	191-206	sulfatase 1	Gallus gallus	128-133
16678777-0	2006	Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis.	Heparitin Sulfate	0-15	kinase insert domain receptor	Homo sapiens	37-42
16681652-1	2006	The heparan sulfate proteoglycan, glypican-1, is a low affinity receptor for fibroblast growth factor 2 (FGF2).	Heparitin Sulfate	4-19	glypican-1	Meleagris gallopavo	34-44
16681652-1	2006	The heparan sulfate proteoglycan, glypican-1, is a low affinity receptor for fibroblast growth factor 2 (FGF2).	Heparitin Sulfate	4-19	fibroblast growth factor 2	Meleagris gallopavo	77-103
16681652-1	2006	The heparan sulfate proteoglycan, glypican-1, is a low affinity receptor for fibroblast growth factor 2 (FGF2).	Heparitin Sulfate	4-19	fibroblast growth factor 2	Meleagris gallopavo	105-109
16604063-2	2006	Here, we have identified Xenopus syndecan-4 (xSyn4), a cell-surface transmembrane heparan sulphate proteoglycan.	Heparitin Sulfate	82-98	syndecan 4 S homeolog	Xenopus laevis	33-43
16618101-0	2006	Affinity, kinetic, and structural study of the interaction of 3-O-sulfotransferase isoform 1 with heparan sulfate.	Heparitin Sulfate	98-113	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	62-92
16618101-1	2006	The 3-O-sulfonation of glucosamine residues in heparan sulfate (HS) by 3-O-sulfotransferase (3-OST) is a key substitution that is present in HS sequences of biological importance, in particular HS anticoagulant activity.	Heparitin Sulfate	47-62	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	71-91
16618101-1	2006	The 3-O-sulfonation of glucosamine residues in heparan sulfate (HS) by 3-O-sulfotransferase (3-OST) is a key substitution that is present in HS sequences of biological importance, in particular HS anticoagulant activity.	Heparitin Sulfate	47-62	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	93-98
16618101-1	2006	The 3-O-sulfonation of glucosamine residues in heparan sulfate (HS) by 3-O-sulfotransferase (3-OST) is a key substitution that is present in HS sequences of biological importance, in particular HS anticoagulant activity.	Heparitin Sulfate	64-66	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	71-91
16618101-1	2006	The 3-O-sulfonation of glucosamine residues in heparan sulfate (HS) by 3-O-sulfotransferase (3-OST) is a key substitution that is present in HS sequences of biological importance, in particular HS anticoagulant activity.	Heparitin Sulfate	64-66	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	93-98
16357320-4	2006	TACI binding appears to require heparan sulfate posttranslational modifications of syndecan-2, because free heparin or pretreatment with heparitinase blocked the interaction.	Heparitin Sulfate	32-47	syndecan 2	Homo sapiens	83-93
16436387-1	2006	The plasma protein histidine-rich glycoprotein (HRGP), which has been identified as an angiogenesis inhibitor, binds to heparan sulfate (HS) in a Zn(2+)-dependent manner.	Heparitin Sulfate	137-139	histidine rich glycoprotein	Homo sapiens	48-52
16436387-0	2006	The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner.	Heparitin Sulfate	99-114	histidine rich glycoprotein	Homo sapiens	45-72
16436387-5	2006	We now show that HRGP330 binds heparin/HS with the same capacity as full-length HRGP, and the binding is Zn(2+)-dependent.	Heparitin Sulfate	39-41	histidine rich glycoprotein	Homo sapiens	17-21
16380211-3	2006	Most intriguing is the loss of heparan sulfate (HS) proteoglycans (HSPG) specifically from the basolateral surface of intestinal epithelial cells only during PLE episodes suggesting a direct link to protein leakage.	Heparitin Sulfate	31-46	syndecan 2	Homo sapiens	67-71
16436387-1	2006	The plasma protein histidine-rich glycoprotein (HRGP), which has been identified as an angiogenesis inhibitor, binds to heparan sulfate (HS) in a Zn(2+)-dependent manner.	Heparitin Sulfate	120-135	histidine rich glycoprotein	Homo sapiens	19-46
16436387-1	2006	The plasma protein histidine-rich glycoprotein (HRGP), which has been identified as an angiogenesis inhibitor, binds to heparan sulfate (HS) in a Zn(2+)-dependent manner.	Heparitin Sulfate	120-135	histidine rich glycoprotein	Homo sapiens	48-52
16436387-1	2006	The plasma protein histidine-rich glycoprotein (HRGP), which has been identified as an angiogenesis inhibitor, binds to heparan sulfate (HS) in a Zn(2+)-dependent manner.	Heparitin Sulfate	137-139	histidine rich glycoprotein	Homo sapiens	19-46
16217746-2	2006	Heparanase is the predominant enzyme involved in cleavage of heparan sulfate, the main polysaccharide component of the extracellular matrix.	Heparitin Sulfate	61-76	heparanase	Homo sapiens	0-10
16442624-7	2006	We also found that KCP binds to heparan sulfate and weakly to glycosaminoglycans at the surface of cells.	Heparitin Sulfate	32-47	kielin cysteine rich BMP regulator	Homo sapiens	19-22
16442624-8	2006	This might indicate that KCP at the surface of viral particles aids in the primary attachment to the target cells, which is known to involve binding to heparan sulfate.	Heparitin Sulfate	152-167	kielin cysteine rich BMP regulator	Homo sapiens	25-28
16506790-2	2006	Heparan sulfate proteoglycans are key components of the extracellular matrix and cell surfaces and are known to bind MPO avidly via their negatively charged heparan sulfate chains.	Heparitin Sulfate	0-15	myeloperoxidase	Homo sapiens	117-120
16532012-2	2006	In biosynthesis of heparan sulfate (HS), a structurally related polysaccharide, HS glucuronyl C5-epimerase (Hsepi) converts D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) residues.	Heparitin Sulfate	19-34	glucuronyl C5-epimerase	Mus musculus	80-106
16532012-2	2006	In biosynthesis of heparan sulfate (HS), a structurally related polysaccharide, HS glucuronyl C5-epimerase (Hsepi) converts D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) residues.	Heparitin Sulfate	19-34	glucuronyl C5-epimerase	Mus musculus	108-113
16532012-2	2006	In biosynthesis of heparan sulfate (HS), a structurally related polysaccharide, HS glucuronyl C5-epimerase (Hsepi) converts D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) residues.	Heparitin Sulfate	36-38	glucuronyl C5-epimerase	Mus musculus	80-106
16532012-2	2006	In biosynthesis of heparan sulfate (HS), a structurally related polysaccharide, HS glucuronyl C5-epimerase (Hsepi) converts D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) residues.	Heparitin Sulfate	36-38	glucuronyl C5-epimerase	Mus musculus	108-113
16458254-1	2006	Heparanase is a mammalian endo-beta-D-glucuronidase that cleaves heparan sulfate side chains at a limited number of sites.	Heparitin Sulfate	65-80	heparanase	Homo sapiens	0-10
16407285-6	2006	WARP interacts with domain III-2 of the perlecan core protein and the heparan sulfate chains of the perlecan domain I with K(D) values in the low nanomolar range.	Heparitin Sulfate	70-85	von Willebrand factor A domain containing 1	Mus musculus	0-4
16506790-2	2006	Heparan sulfate proteoglycans are key components of the extracellular matrix and cell surfaces and are known to bind MPO avidly via their negatively charged heparan sulfate chains.	Heparitin Sulfate	157-172	myeloperoxidase	Homo sapiens	117-120
16506790-10	2006	The degradation of heparan sulfate via reductive homolysis of its N-chloro derivatives may be of significance at sites of inflammation, where MPO-derived HOCl is produced in high concentration and transition-metal ions and O(2)(*-) are known to be present or generated.	Heparitin Sulfate	19-34	myeloperoxidase	Homo sapiens	142-145
16465447-5	2006	Signal specificity of VEGF receptors is further modulated upon recruitment of coreceptors, such as neuropilins, heparan sulfate, integrins or cadherins.	Heparitin Sulfate	112-127	vascular endothelial growth factor A	Homo sapiens	22-26
16503664-0	2006	Structural and thermodynamic aspects of the interaction between heparan sulfate and analogues of melittin.	Heparitin Sulfate	64-79	melittin	Apis mellifera	97-105
16503664-4	2006	In the present work, we characterize the binding equilibrium of heparan sulfate (HS) with two melittin analogues, [Cys(1)]melittin (mel-SH) and retro-inverso [Cys(1)]melittin (ri-mel-SH).	Heparitin Sulfate	64-79	melittin	Apis mellifera	94-102
16503664-4	2006	In the present work, we characterize the binding equilibrium of heparan sulfate (HS) with two melittin analogues, [Cys(1)]melittin (mel-SH) and retro-inverso [Cys(1)]melittin (ri-mel-SH).	Heparitin Sulfate	64-79	melittin	Apis mellifera	122-130
16503664-4	2006	In the present work, we characterize the binding equilibrium of heparan sulfate (HS) with two melittin analogues, [Cys(1)]melittin (mel-SH) and retro-inverso [Cys(1)]melittin (ri-mel-SH).	Heparitin Sulfate	64-79	melittin	Apis mellifera	122-130
16503664-4	2006	In the present work, we characterize the binding equilibrium of heparan sulfate (HS) with two melittin analogues, [Cys(1)]melittin (mel-SH) and retro-inverso [Cys(1)]melittin (ri-mel-SH).	Heparitin Sulfate	81-83	melittin	Apis mellifera	94-102
16503664-4	2006	In the present work, we characterize the binding equilibrium of heparan sulfate (HS) with two melittin analogues, [Cys(1)]melittin (mel-SH) and retro-inverso [Cys(1)]melittin (ri-mel-SH).	Heparitin Sulfate	81-83	melittin	Apis mellifera	122-130
16503664-4	2006	In the present work, we characterize the binding equilibrium of heparan sulfate (HS) with two melittin analogues, [Cys(1)]melittin (mel-SH) and retro-inverso [Cys(1)]melittin (ri-mel-SH).	Heparitin Sulfate	81-83	melittin	Apis mellifera	122-130
16247452-1	2006	The induction of the cell surface heparan sulfate proteoglycan syndecan-1 (Sdc1) in stromal fibroblasts is observed in more than 70% of human breast carcinomas.	Heparitin Sulfate	34-49	syndecan 1	Homo sapiens	63-73
16247452-1	2006	The induction of the cell surface heparan sulfate proteoglycan syndecan-1 (Sdc1) in stromal fibroblasts is observed in more than 70% of human breast carcinomas.	Heparitin Sulfate	34-49	syndecan 1	Homo sapiens	75-79
16503804-7	2006	Further, the proliferative response of the striatum to bFGF administration could be enhanced twofold by supplementing this growth factor with heparin sulfate, a factor that facilitates the binding of bFGF to its receptors.	Heparitin Sulfate	142-157	fibroblast growth factor 2	Rattus norvegicus	55-59
16452201-1	2006	Heparanase is an endo-beta-D-glucuronidase involved in cleavage of heparan sulfate moieties and hence participates in extracellular matrix (ECM) degradation and remodeling.	Heparitin Sulfate	67-82	heparanase	Homo sapiens	0-10
16452201-1	2006	Heparanase is an endo-beta-D-glucuronidase involved in cleavage of heparan sulfate moieties and hence participates in extracellular matrix (ECM) degradation and remodeling.	Heparitin Sulfate	67-82	glucuronidase beta	Homo sapiens	22-42
16288472-1	2006	Heparanase (HPSE-1) is an endo-beta-D-glucuronidase that cleaves heparan sulfate (HS) chains of proteoglycans (HSPG), and its expression has been associated with increased cell growth, invasion, and angiogenesis of tumors as well as with embryogenesis and tissue development.	Heparitin Sulfate	65-80	heparanase	Homo sapiens	12-18
16288472-1	2006	Heparanase (HPSE-1) is an endo-beta-D-glucuronidase that cleaves heparan sulfate (HS) chains of proteoglycans (HSPG), and its expression has been associated with increased cell growth, invasion, and angiogenesis of tumors as well as with embryogenesis and tissue development.	Heparitin Sulfate	65-80	glucuronidase beta	Homo sapiens	31-51
16288472-1	2006	Heparanase (HPSE-1) is an endo-beta-D-glucuronidase that cleaves heparan sulfate (HS) chains of proteoglycans (HSPG), and its expression has been associated with increased cell growth, invasion, and angiogenesis of tumors as well as with embryogenesis and tissue development.	Heparitin Sulfate	65-80	syndecan 2	Homo sapiens	111-115
16288472-1	2006	Heparanase (HPSE-1) is an endo-beta-D-glucuronidase that cleaves heparan sulfate (HS) chains of proteoglycans (HSPG), and its expression has been associated with increased cell growth, invasion, and angiogenesis of tumors as well as with embryogenesis and tissue development.	Heparitin Sulfate	82-84	heparanase	Homo sapiens	12-18
16288472-1	2006	Heparanase (HPSE-1) is an endo-beta-D-glucuronidase that cleaves heparan sulfate (HS) chains of proteoglycans (HSPG), and its expression has been associated with increased cell growth, invasion, and angiogenesis of tumors as well as with embryogenesis and tissue development.	Heparitin Sulfate	82-84	glucuronidase beta	Homo sapiens	31-51
16288472-1	2006	Heparanase (HPSE-1) is an endo-beta-D-glucuronidase that cleaves heparan sulfate (HS) chains of proteoglycans (HSPG), and its expression has been associated with increased cell growth, invasion, and angiogenesis of tumors as well as with embryogenesis and tissue development.	Heparitin Sulfate	82-84	syndecan 2	Homo sapiens	111-115
16429446-3	2006	Heparan sulfate chains (HS) of HSPG bind and sequester a multitude of extracellular ligands, including growth factors, cytokines, chemokines, enzymes, and lipoproteins.	Heparitin Sulfate	0-15	syndecan 2	Homo sapiens	31-35
16373349-12	2006	In summary, antibody HS4C3 selectively detects 3-O-sulfated HS structures and interferes with the coagulation activities of heparin by association with the anti-thrombin binding pentasaccharide sequence.	Heparitin Sulfate	21-23	coagulation factor II	Rattus norvegicus	161-169
16474431-8	2006	The specific binding of MK to the surface nucleolin is independent of heparan sulfate and chondroitin sulfate proteoglycans.	Heparitin Sulfate	70-85	nucleolin	Homo sapiens	42-51
16503804-7	2006	Further, the proliferative response of the striatum to bFGF administration could be enhanced twofold by supplementing this growth factor with heparin sulfate, a factor that facilitates the binding of bFGF to its receptors.	Heparitin Sulfate	142-157	fibroblast growth factor 2	Rattus norvegicus	200-204
16507142-0	2006	CXCL12 is displayed by rheumatoid endothelial cells through its basic amino-terminal motif on heparan sulfate proteoglycans.	Heparitin Sulfate	94-109	C-X-C motif chemokine ligand 12	Homo sapiens	0-6
16303756-3	2006	So far, in vitro glycosyltransferase activities have been demonstrated only for BOTV/DEXTL3, which harbors both N-acetylglucosaminyltransferase-I (GlcNAcT-I) and N-acetylglucosaminyltransferase-II (GlcNAcT-II) activities responsible for the chain initiation and elongation of HS, and no glucuronyltransferase-II (GlcAT-II) activity.	Heparitin Sulfate	276-278	brother of tout-velu	Drosophila melanogaster	80-84
16303756-3	2006	So far, in vitro glycosyltransferase activities have been demonstrated only for BOTV/DEXTL3, which harbors both N-acetylglucosaminyltransferase-I (GlcNAcT-I) and N-acetylglucosaminyltransferase-II (GlcNAcT-II) activities responsible for the chain initiation and elongation of HS, and no glucuronyltransferase-II (GlcAT-II) activity.	Heparitin Sulfate	276-278	brother of tout-velu	Drosophila melanogaster	85-91
16423696-3	2006	Slit2-CM elicits rapid activation of translation regulators and MAP kinases in growth cones, and inhibition of MAPKs or disruption of heparan sulfate blocks Slit2-CM-induced PS and repulsion.	Heparitin Sulfate	134-149	slit guidance ligand 2 S homeolog	Xenopus laevis	0-5
16423696-3	2006	Slit2-CM elicits rapid activation of translation regulators and MAP kinases in growth cones, and inhibition of MAPKs or disruption of heparan sulfate blocks Slit2-CM-induced PS and repulsion.	Heparitin Sulfate	134-149	slit guidance ligand 2 S homeolog	Xenopus laevis	157-162
16280358-0	2006	Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate.	Heparitin Sulfate	125-140	granzyme B	Homo sapiens	28-38
16280358-7	2006	In pulldown assays mediated by the cation-independent mannose 6-phosphate receptor, granzyme B bound to the receptor more intensely in the presence of immobilized heparan sulfate.	Heparitin Sulfate	163-178	granzyme B	Homo sapiens	84-94
16343444-2	2006	Heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase isoform 2 (NDST-2), a key enzyme in the biosynthesis of heparin, contains two distinct activities.	Heparitin Sulfate	0-15	N-deacetylase and N-sulfotransferase 2	Homo sapiens	29-71
16343444-2	2006	Heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase isoform 2 (NDST-2), a key enzyme in the biosynthesis of heparin, contains two distinct activities.	Heparitin Sulfate	0-15	N-deacetylase and N-sulfotransferase 2	Homo sapiens	73-79
15920756-7	2006	BMP-2 also produced an augment in the synthesis of different heparan sulfate proteoglycans such syndecan-2, - 3, glypican, and perlecan in detergent-soluble and non-soluble cellular fractions.	Heparitin Sulfate	61-76	bone morphogenetic protein 2	Mus musculus	0-5
16394262-3	2006	Heparan sulfate enables growth factor function and modifies enzyme/inhibitor functions, such as antithrombin III and heparin cofactor II.	Heparitin Sulfate	0-15	serpin family C member 1	Homo sapiens	96-112
16223867-4	2006	Because heparan sulfate (HS) proteoglycans (Prgs) (HSPGs) are absolutely required by these signaling pathways, we have investigated whether thyroid status affects HSPG expression within the growth plate.	Heparitin Sulfate	25-27	syndecan 2	Mus musculus	51-55
16684668-7	2006	Heparan sulfate (HS), in particular, has been shown to increase T-cell proliferative response in non TB-mouse splenocytes as well as promotion of a beneficial Th1 response.	Heparitin Sulfate	0-15	negative elongation factor complex member C/D, Th1l	Mus musculus	159-162
16684668-7	2006	Heparan sulfate (HS), in particular, has been shown to increase T-cell proliferative response in non TB-mouse splenocytes as well as promotion of a beneficial Th1 response.	Heparitin Sulfate	17-19	negative elongation factor complex member C/D, Th1l	Mus musculus	159-162
16226436-0	2006	Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation.	Heparitin Sulfate	0-15	syndecan 3	Homo sapiens	40-50
16365408-3	2006	In this study we found that DcR3.Fc-induced cell adhesion was inhibited by heparin and heparan sulfate, and that DcR3.Fc was unable to bind Chinese hamster ovary K1 mutants defective in glycosaminoglycan (GAG) synthesis.	Heparitin Sulfate	87-102	TNF receptor superfamily member 6b	Homo sapiens	28-32
16226436-0	2006	Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation.	Heparitin Sulfate	0-15	bone morphogenetic protein 1	Homo sapiens	60-63
16226436-3	2006	Here we have explored the role of HSPGs in regulating BMP activity during limb chondrogenesis by evaluating the effects of exogenous heparan sulfate (HS), heparitinase treatment, and overexpression of the HSPG syndecan-3 on the ability of BMP2 to modulate the chondrogenic differentiation of limb mesenchymal cells in micromass culture.	Heparitin Sulfate	34-36	bone morphogenetic protein 1	Homo sapiens	54-57
16260789-4	2005	By selecting appropriate enzymatic modification steps, an inactive precursor has been converted to the heparan sulfate having three distinct biological activities, associated with binding to antithrombin, fibroblast growth factor-2, and herpes simplex virus envelope glycoprotein D. Because the recombinant sulfotransferases are expressed in bacteria, and the method uses a low cost sulfo donor, it can be readily utilized to synthesize large quantities of anticoagulant heparin drug or other biologically active heparan sulfates.	Heparitin Sulfate	103-118	serpin family C member 1	Homo sapiens	191-203
16846011-2	2006	In the case of mucopolysaccharidosis type IIIA, a lack of active sulfamidase enzyme results in heparan sulfate accumulation, severe and progressive neurological deficits, and usually premature death.	Heparitin Sulfate	95-110	N-sulfoglucosamine sulfohydrolase	Homo sapiens	15-46
17115009-5	2006	Most often they seem to be proteoglycans containing heparan sulfate and chondroitin sulfate, which can also be a part of the multimolecular receptor complexes binding midkine.	Heparitin Sulfate	52-67	midkine	Homo sapiens	167-174
16263714-7	2005	It has been reported that heparan sulfate on glypican-1 plays important roles in spermine uptake by human embryonic lung fibroblasts.	Heparitin Sulfate	26-41	glypican 1	Homo sapiens	45-55
16260789-4	2005	By selecting appropriate enzymatic modification steps, an inactive precursor has been converted to the heparan sulfate having three distinct biological activities, associated with binding to antithrombin, fibroblast growth factor-2, and herpes simplex virus envelope glycoprotein D. Because the recombinant sulfotransferases are expressed in bacteria, and the method uses a low cost sulfo donor, it can be readily utilized to synthesize large quantities of anticoagulant heparin drug or other biologically active heparan sulfates.	Heparitin Sulfate	103-118	fibroblast growth factor 2	Homo sapiens	205-231
16219767-1	2005	The related glycosaminoglycans heparin and heparan sulfate are essential for the activity of the fibroblast growth factor (FGF) family as they form an integral part of the signaling complex at the cell surface.	Heparitin Sulfate	43-58	fibroblast growth factor 1	Homo sapiens	123-126
16219767-9	2005	A cooperative mechanism of FGF1 dimerization could explain how 2:2:1 signaling complexes form at the cell surface, an environment rich in heparan sulfate.	Heparitin Sulfate	138-153	fibroblast growth factor 1	Homo sapiens	27-31
16155004-0	2005	The two thrombospondin type I repeat domains of the heparin-binding growth-associated molecule bind to heparin/heparan sulfate and regulate neurite extension and plasticity in hippocampal neurons.	Heparitin Sulfate	111-126	pleiotrophin	Homo sapiens	52-94
16155004-1	2005	HB-GAM (heparin-binding growth-associated molecule, also designated as pleiotrophin) and midkine form a two-member family of extracellular matrix proteins that bind tightly to sulfated carbohydrate structures such as heparan sulfate.	Heparitin Sulfate	217-232	pleiotrophin	Homo sapiens	0-6
16155004-1	2005	HB-GAM (heparin-binding growth-associated molecule, also designated as pleiotrophin) and midkine form a two-member family of extracellular matrix proteins that bind tightly to sulfated carbohydrate structures such as heparan sulfate.	Heparitin Sulfate	217-232	pleiotrophin	Homo sapiens	71-83
16155004-1	2005	HB-GAM (heparin-binding growth-associated molecule, also designated as pleiotrophin) and midkine form a two-member family of extracellular matrix proteins that bind tightly to sulfated carbohydrate structures such as heparan sulfate.	Heparitin Sulfate	217-232	pleiotrophin	Homo sapiens	8-50
16192265-2	2005	Recent studies show that when the levels of 6-O-sulfation of heparan sulfate are diminished by the activity of extracellular heparan sulfate 6-O-endosulfatases (Sulfs), fibroblast growth factor 2-, heparin binding epidermal growth factor-, and hepatocyte growth factor-mediated signaling are attenuated.	Heparitin Sulfate	61-76	fibroblast growth factor 2	Homo sapiens	169-195
16289417-14	2005	In perlecan or dystroglycan null mice there is no accumulation of AChE at the NMJ, supporting the hypothesis that this heparan sulfate proteoglycan is an essential component of the ColQ-AChE localization mechanism.	Heparitin Sulfate	119-134	dystroglycan 1	Mus musculus	15-27
16289417-14	2005	In perlecan or dystroglycan null mice there is no accumulation of AChE at the NMJ, supporting the hypothesis that this heparan sulfate proteoglycan is an essential component of the ColQ-AChE localization mechanism.	Heparitin Sulfate	119-134	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	Mus musculus	181-185
16289417-14	2005	In perlecan or dystroglycan null mice there is no accumulation of AChE at the NMJ, supporting the hypothesis that this heparan sulfate proteoglycan is an essential component of the ColQ-AChE localization mechanism.	Heparitin Sulfate	119-134	acetylcholinesterase	Mus musculus	186-190
16289417-16	2005	At mature synapses ColQ-AChE is secreted directly into the synaptic cleft where it binds to the heparan sulfate proteoglycan perlecan as well as potentially other molecules including MuSK, as was recently reported.	Heparitin Sulfate	96-111	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	Mus musculus	19-23
16289417-16	2005	At mature synapses ColQ-AChE is secreted directly into the synaptic cleft where it binds to the heparan sulfate proteoglycan perlecan as well as potentially other molecules including MuSK, as was recently reported.	Heparitin Sulfate	96-111	acetylcholinesterase	Mus musculus	24-28
16168454-1	2005	Recent data suggest that heparin sulfates may bind to a CD4 induced epitope in the HIV-1 gp120 that constitutes the coreceptor binding site.	Heparitin Sulfate	25-41	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	89-94
16192265-2	2005	Recent studies show that when the levels of 6-O-sulfation of heparan sulfate are diminished by the activity of extracellular heparan sulfate 6-O-endosulfatases (Sulfs), fibroblast growth factor 2-, heparin binding epidermal growth factor-, and hepatocyte growth factor-mediated signaling are attenuated.	Heparitin Sulfate	125-140	fibroblast growth factor 2	Homo sapiens	169-195
16314481-4	2005	Compared with both normal and nonlesional fibroblasts, lesional dSSc fibroblasts overexpressed the heparin sulfate-containing proteoglycan syndecan 4.	Heparitin Sulfate	99-114	syndecan 4	Homo sapiens	139-149
16351786-1	2005	BACKGROUND &amp; OBJECTIVE: Heparanase (Hpa) is an endoglycosidase that degrades heparin sulfate--the main polysaccharide constituent of extracellular matrix (ECM) and basement.	Heparitin Sulfate	81-96	heparanase	Homo sapiens	28-38
16351786-1	2005	BACKGROUND &amp; OBJECTIVE: Heparanase (Hpa) is an endoglycosidase that degrades heparin sulfate--the main polysaccharide constituent of extracellular matrix (ECM) and basement.	Heparitin Sulfate	81-96	heparanase	Homo sapiens	40-43
16283885-2	2005	MO is caused by mutations in the EXT1 or EXT2 genes, which encode glycosyltransferases implicated in heparan sulfate biosynthesis.	Heparitin Sulfate	101-116	exostosin glycosyltransferase 1	Homo sapiens	33-37
16283885-2	2005	MO is caused by mutations in the EXT1 or EXT2 genes, which encode glycosyltransferases implicated in heparan sulfate biosynthesis.	Heparitin Sulfate	101-116	exostosin glycosyltransferase 2	Homo sapiens	41-45
16303928-3	2005	The present study investigated whether opticin interacts directly with the heparan sulfate (HS) proteoglycan type XVIII collagen.	Heparitin Sulfate	75-90	opticin	Homo sapiens	39-46
16035076-4	2005	We report that the heparan sulfate proteoglycan, syndecan-3, becomes highly enriched with PNS node formation; its ligand, collagen V, is also concentrated at the PNS nodes and at lower levels along the abaxonal membrane.	Heparitin Sulfate	19-34	syndecan 3	Mus musculus	49-59
16037493-5	2005	In the studies reported here, we show that agrin binds to alpha-synuclein in a heparan sulfate-dependent (HS-dependent) manner, induces conformational changes in this protein characterized by beta-sheet structure, and enhances insolubility of alpha-synuclein.	Heparitin Sulfate	79-94	agrin	Homo sapiens	43-48
16037493-5	2005	In the studies reported here, we show that agrin binds to alpha-synuclein in a heparan sulfate-dependent (HS-dependent) manner, induces conformational changes in this protein characterized by beta-sheet structure, and enhances insolubility of alpha-synuclein.	Heparitin Sulfate	79-94	synuclein alpha	Homo sapiens	58-73
16303928-9	2005	CONCLUSIONS: Opticin binds to heparin, HS, chondroitin 4-sulfate, and dermatan sulfate, the binding affinity being dependent on sulfation pattern and oligosaccharide chain length.	Heparitin Sulfate	39-41	opticin	Homo sapiens	13-20
16303928-3	2005	The present study investigated whether opticin interacts directly with the heparan sulfate (HS) proteoglycan type XVIII collagen.	Heparitin Sulfate	92-94	opticin	Homo sapiens	39-46
16220285-9	2005	Moreover, the axon guidance activities by Slit and semaphorin 5A require the existence of heparan sulfate, which binds to numerous guidance molecules.	Heparitin Sulfate	90-105	semaphorin 5A	Homo sapiens	51-64
15920546-1	2005	Expression profiling of hepatocellular carcinoma has demonstrated that glypican 3 (GPC3), a heparan sulfate proteoglycan anchored to the membrane, is expressed at a markedly elevated level in hepatocellular carcinoma.	Heparitin Sulfate	92-107	glypican 3	Homo sapiens	71-81
15920546-1	2005	Expression profiling of hepatocellular carcinoma has demonstrated that glypican 3 (GPC3), a heparan sulfate proteoglycan anchored to the membrane, is expressed at a markedly elevated level in hepatocellular carcinoma.	Heparitin Sulfate	92-107	glypican 3	Homo sapiens	83-87
15951190-2	2005	In addition, several lines of evidence suggest that glycosaminoglycans (GAGs) and in particular heparan sulfate (HS) may play a role in the PrP(C) to PrP(Sc) conversion process.	Heparitin Sulfate	96-111	prion protein	Mus musculus	140-143
15951190-2	2005	In addition, several lines of evidence suggest that glycosaminoglycans (GAGs) and in particular heparan sulfate (HS) may play a role in the PrP(C) to PrP(Sc) conversion process.	Heparitin Sulfate	113-115	prion protein	Mus musculus	140-143
16317389-3	2005	Syndecan-1 is the predominant cell surface heparan sulfate proteoglycan expressed on epithelia, and there is substantial evidence that heparan sulfate participates in interactions of a variety of frankly pathogenic microbes with mammalian cells.	Heparitin Sulfate	43-58	syndecan 1	Homo sapiens	0-10
16317389-7	2005	Data from experiments with Chinese hamster ovary cells with altered glycosaminoglycan expression indicated that heparan sulfate and chondroitin sulfate (glycosaminoglycans on the syndecan-1 ectodomain) participated in bacterial interactions with mammalian cells.	Heparitin Sulfate	112-127	syndecan-1	Cricetulus griseus	179-189
16107334-1	2005	Endothelial and other select cell types synthesize a subpopulation of heparan sulfate (HS) proteoglycans (HSPGs), anticoagulant HSPGs (aHSPGs) that bear aHS-HS chains with the cognate 3-O-sulfated pentasaccharide motif that can bind and activate anti-thrombin (AT).	Heparitin Sulfate	70-85	coagulation factor II, thrombin	Homo sapiens	251-259
16288042-0	2005	Laminin alpha5 chain metastasis- and angiogenesis-inhibiting peptide blocks fibroblast growth factor 2 activity by binding to the heparan sulfate chains of CD44.	Heparitin Sulfate	130-145	laminin subunit alpha 5	Homo sapiens	0-20
16288042-0	2005	Laminin alpha5 chain metastasis- and angiogenesis-inhibiting peptide blocks fibroblast growth factor 2 activity by binding to the heparan sulfate chains of CD44.	Heparitin Sulfate	130-145	fibroblast growth factor 2	Homo sapiens	76-102
16288042-0	2005	Laminin alpha5 chain metastasis- and angiogenesis-inhibiting peptide blocks fibroblast growth factor 2 activity by binding to the heparan sulfate chains of CD44.	Heparitin Sulfate	130-145	CD44 molecule (Indian blood group)	Homo sapiens	156-160
16288042-8	2005	We conclude that peptide A5G27 inhibits metastasis and angiogenesis by blocking FGF2 binding to the heparan sulfate side chains of CD44 variant 3, thus decreasing FGF2 bioactivity.	Heparitin Sulfate	100-115	fibroblast growth factor 2	Homo sapiens	80-84
16288042-8	2005	We conclude that peptide A5G27 inhibits metastasis and angiogenesis by blocking FGF2 binding to the heparan sulfate side chains of CD44 variant 3, thus decreasing FGF2 bioactivity.	Heparitin Sulfate	100-115	CD44 molecule (Indian blood group)	Homo sapiens	131-135
16262248-0	2005	Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46.	Heparitin Sulfate	32-47	natural cytotoxicity triggering receptor 1	Homo sapiens	98-103
16155294-0	2005	Heparan sulfate mimicry: a synthetic glycoconjugate that recognizes the heparin binding domain of interferon-gamma inhibits the cytokine activity.	Heparitin Sulfate	0-15	interferon gamma	Homo sapiens	98-114
16262248-3	2005	We have recently shown that NKp46 recognizes the heparan sulfate moieties of membranal heparan sulfate proteoglycans (HSPGs), thus enabling lysis of tumor cells by NK cells.	Heparitin Sulfate	49-64	natural cytotoxicity triggering receptor 1	Homo sapiens	28-33
16262248-4	2005	In the current study, we further examined the residues in NKp46 that may be involved in heparan sulfate binding on tumor cells.	Heparitin Sulfate	88-103	natural cytotoxicity triggering receptor 1	Homo sapiens	58-63
16262248-5	2005	On the basis of both the electrostatic potential map and comparison to the heparin binding site on human fibronectin, we predicted a continuous region containing the basic amino acids K133, R136, H139, R142, and K146 to be involved in NKp46 binding to heparan sulfate.	Heparitin Sulfate	252-267	fibronectin 1	Homo sapiens	105-116
16262248-5	2005	On the basis of both the electrostatic potential map and comparison to the heparin binding site on human fibronectin, we predicted a continuous region containing the basic amino acids K133, R136, H139, R142, and K146 to be involved in NKp46 binding to heparan sulfate.	Heparitin Sulfate	252-267	natural cytotoxicity triggering receptor 1	Homo sapiens	235-240
16262248-7	2005	The minimal length of the heparin/heparan sulfate epitope recognized by NKp46 was eight saccharides as predicted from the structure and proven by testing heparin oligomers.	Heparitin Sulfate	34-49	natural cytotoxicity triggering receptor 1	Homo sapiens	72-77
16262248-9	2005	The characterization of heparan sulfate binding region in NKp46 offers further insight into the identity of the ligands for NKp46 and the interaction of NK and cancers.	Heparitin Sulfate	24-39	natural cytotoxicity triggering receptor 1	Homo sapiens	58-63
16262248-9	2005	The characterization of heparan sulfate binding region in NKp46 offers further insight into the identity of the ligands for NKp46 and the interaction of NK and cancers.	Heparitin Sulfate	24-39	natural cytotoxicity triggering receptor 1	Homo sapiens	124-129
16246059-0	2005	Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.	Heparitin Sulfate	6-22	amyloid beta precursor protein	Homo sapiens	75-100
15966019-1	2005	BACKGROUND: Hunter syndrome, mucopolysaccharidosis type II (MPS II), is a X-linked inherited disorder caused by the deficiency of the enzyme iduronate-2-sulfatase (IDS), involved in the lysosomal catabolism of the glycosaminoglycans (GAG) dermatan and heparan sulfate.	Heparitin Sulfate	252-267	iduronate 2-sulfatase	Mus musculus	141-162
16221725-5	2005	We find that fgf10 mutants strongly resemble zebrafish ext2 and extl3 mutants, which encode glycosyltransferases required for heparan sulphate biosynthesis.	Heparitin Sulfate	126-142	fibroblast growth factor 10a	Danio rerio	13-18
16221725-5	2005	We find that fgf10 mutants strongly resemble zebrafish ext2 and extl3 mutants, which encode glycosyltransferases required for heparan sulphate biosynthesis.	Heparitin Sulfate	126-142	exostosin glycosyltransferase 2	Danio rerio	55-59
16221725-5	2005	We find that fgf10 mutants strongly resemble zebrafish ext2 and extl3 mutants, which encode glycosyltransferases required for heparan sulphate biosynthesis.	Heparitin Sulfate	126-142	exostosin-like glycosyltransferase 3	Danio rerio	64-69
16236767-0	2005	Mice deficient in Ext2 lack heparan sulfate and develop exostoses.	Heparitin Sulfate	28-43	exostosin glycosyltransferase 2	Mus musculus	18-22
16236767-2	2005	HME results from mutations in EXT1 and EXT2, genes that encode glycosyltransferases that synthesize heparan sulfate chains.	Heparitin Sulfate	100-115	exostosin glycosyltransferase 1	Mus musculus	30-34
16236767-2	2005	HME results from mutations in EXT1 and EXT2, genes that encode glycosyltransferases that synthesize heparan sulfate chains.	Heparitin Sulfate	100-115	exostosin glycosyltransferase 2	Mus musculus	39-43
15966019-1	2005	BACKGROUND: Hunter syndrome, mucopolysaccharidosis type II (MPS II), is a X-linked inherited disorder caused by the deficiency of the enzyme iduronate-2-sulfatase (IDS), involved in the lysosomal catabolism of the glycosaminoglycans (GAG) dermatan and heparan sulfate.	Heparitin Sulfate	252-267	iduronate 2-sulfatase	Mus musculus	164-167
16107330-3	2005	Previous studies have shown that histidine-rich glycoprotein (HRG), an abundant (approximately 100 microg/ml) 75-kDa plasma glycoprotein, binds to cell surface heparan sulfate on viable cells and cross-links other ligands, such as plasminogen, to the cell surface.	Heparitin Sulfate	160-175	histidine rich glycoprotein	Homo sapiens	62-65
15899505-2	2005	Extracellular SOD (EC-SOD/SOD3) is a major superoxide scavenger and it is located on cell surfaces and primarily in extracellular matrix, and binds heparan sulfates by its carboxyterminal portion.	Heparitin Sulfate	148-164	superoxide dismutase 3	Homo sapiens	14-17
15899505-2	2005	Extracellular SOD (EC-SOD/SOD3) is a major superoxide scavenger and it is located on cell surfaces and primarily in extracellular matrix, and binds heparan sulfates by its carboxyterminal portion.	Heparitin Sulfate	148-164	superoxide dismutase 3	Homo sapiens	19-25
15899505-2	2005	Extracellular SOD (EC-SOD/SOD3) is a major superoxide scavenger and it is located on cell surfaces and primarily in extracellular matrix, and binds heparan sulfates by its carboxyterminal portion.	Heparitin Sulfate	148-164	superoxide dismutase 3	Homo sapiens	26-30
16087677-12	2005	Because both plasmin and thrombin are involved in thrombogenic and thrombolytic processes in the course of the pathogenesis of arteriosclerosis, the detachment of heparan sulfate-bearing ectodomains could be relevant for the development of arteriosclerotic plaques and recruitment of mononuclear blood cells to the plaque.	Heparitin Sulfate	163-178	plasminogen	Homo sapiens	13-20
16087677-12	2005	Because both plasmin and thrombin are involved in thrombogenic and thrombolytic processes in the course of the pathogenesis of arteriosclerosis, the detachment of heparan sulfate-bearing ectodomains could be relevant for the development of arteriosclerotic plaques and recruitment of mononuclear blood cells to the plaque.	Heparitin Sulfate	163-178	coagulation factor II, thrombin	Homo sapiens	25-33
16120610-9	2005	Notably, not only heparan sulfate but also CS/DS hybrid chain structures of mammalian brains contain a high degree of microheterogeneity with a cluster of oversulfated disaccharides and appear to play roles in regulating the functions of PTN.	Heparitin Sulfate	18-33	pleiotrophin	Homo sapiens	238-241
16107330-4	2005	In this study we have demonstrated that HRG also binds very strongly, in a heparan sulfate-independent manner, to cytoplasmic ligand(s) exposed in necrotic cells.	Heparitin Sulfate	75-90	histidine rich glycoprotein	Homo sapiens	40-43
16213816-0	2005	The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase.	Heparitin Sulfate	4-19	Syndecan	Drosophila melanogaster	33-41
16213816-0	2005	The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase.	Heparitin Sulfate	4-19	Leukocyte-antigen-related-like	Drosophila melanogaster	82-85
16175541-7	2005	Monte Carlo multiple-minima calculations of low-energy conformers of the FGF-bound ligands showed that all of the sulfated tetracyclitol ligands can bind effectively in the heparan sulfate-binding sites of FGF-1 and FGF-2.	Heparitin Sulfate	173-188	fibroblast growth factor 1	Homo sapiens	73-76
16139897-1	2005	A new class of sulfatases, SulfFP1/sulf-1 and SulfFP2/sulf-2, has been implicated in the modulation of extracellular signaling by remodeling heparan sulfate through 6-O-endosulfatase activity.	Heparitin Sulfate	141-156	sulfatase 1	Rattus norvegicus	27-41
16139897-1	2005	A new class of sulfatases, SulfFP1/sulf-1 and SulfFP2/sulf-2, has been implicated in the modulation of extracellular signaling by remodeling heparan sulfate through 6-O-endosulfatase activity.	Heparitin Sulfate	141-156	sulfatase 2	Rattus norvegicus	54-60
15932347-12	2005	Computational modelling of the reaction of HOCl with heparan sulphate proteoglycans (glypican-1 and perlecan) predicts that the GlcNH2 residues of heparan sulphate are major sites of attack.	Heparitin Sulfate	53-69	glypican 1	Homo sapiens	85-95
15958243-2	2005	The covalently bound heparin provided a crosslinkable analog of a heparan sulfate proteoglycan, thus providing a multivalent biomaterial capable of controlled release of basic fibroblast growth factor (bFGF).	Heparitin Sulfate	66-81	fibroblast growth factor 2	Homo sapiens	170-200
15958243-2	2005	The covalently bound heparin provided a crosslinkable analog of a heparan sulfate proteoglycan, thus providing a multivalent biomaterial capable of controlled release of basic fibroblast growth factor (bFGF).	Heparitin Sulfate	66-81	fibroblast growth factor 2	Homo sapiens	202-206
15976375-2	2005	Binding of IL-8 to heparan sulfate (HS)-containing proteoglycans (HSPG) facilitates binding of the chemokine to its specific receptor, stabilizes and prolongs IL-8 activity, and protects it from proteolysis.	Heparitin Sulfate	19-34	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
15976375-2	2005	Binding of IL-8 to heparan sulfate (HS)-containing proteoglycans (HSPG) facilitates binding of the chemokine to its specific receptor, stabilizes and prolongs IL-8 activity, and protects it from proteolysis.	Heparitin Sulfate	19-34	syndecan 2	Homo sapiens	66-70
15976375-2	2005	Binding of IL-8 to heparan sulfate (HS)-containing proteoglycans (HSPG) facilitates binding of the chemokine to its specific receptor, stabilizes and prolongs IL-8 activity, and protects it from proteolysis.	Heparitin Sulfate	19-34	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
15976375-2	2005	Binding of IL-8 to heparan sulfate (HS)-containing proteoglycans (HSPG) facilitates binding of the chemokine to its specific receptor, stabilizes and prolongs IL-8 activity, and protects it from proteolysis.	Heparitin Sulfate	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
15976375-2	2005	Binding of IL-8 to heparan sulfate (HS)-containing proteoglycans (HSPG) facilitates binding of the chemokine to its specific receptor, stabilizes and prolongs IL-8 activity, and protects it from proteolysis.	Heparitin Sulfate	36-38	syndecan 2	Homo sapiens	66-70
15976375-2	2005	Binding of IL-8 to heparan sulfate (HS)-containing proteoglycans (HSPG) facilitates binding of the chemokine to its specific receptor, stabilizes and prolongs IL-8 activity, and protects it from proteolysis.	Heparitin Sulfate	36-38	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
16175541-7	2005	Monte Carlo multiple-minima calculations of low-energy conformers of the FGF-bound ligands showed that all of the sulfated tetracyclitol ligands can bind effectively in the heparan sulfate-binding sites of FGF-1 and FGF-2.	Heparitin Sulfate	173-188	fibroblast growth factor 1	Homo sapiens	206-211
16175541-7	2005	Monte Carlo multiple-minima calculations of low-energy conformers of the FGF-bound ligands showed that all of the sulfated tetracyclitol ligands can bind effectively in the heparan sulfate-binding sites of FGF-1 and FGF-2.	Heparitin Sulfate	173-188	fibroblast growth factor 2	Homo sapiens	216-221
16141236-7	2005	Heparan sulphate does not affect cell association of PGI/AMF at neutral pH but enhances the FN-independent cell surface association of PGI/AMF at acid pH identifying two distinct mechanisms for PGI/AMF sequestration under acidic conditions.	Heparitin Sulfate	0-16	glucose-6-phosphate isomerase	Homo sapiens	135-138
16181411-1	2005	The second Ig module (IgII) of the neural cell adhesion molecule (NCAM) is known to bind to the first Ig module (IgI) of NCAM (so-called homophilic binding) and to interact with heparan sulfate and chondroitin sulfate glycoconjugates.	Heparitin Sulfate	178-193	neural cell adhesion molecule 1	Homo sapiens	121-125
16188972-0	2005	Heparan sulfate proteoglycans mediate attachment and entry of human T-cell leukemia virus type 1 virions into CD4+ T cells.	Heparitin Sulfate	0-15	CD4 molecule	Homo sapiens	110-113
17216117-4	2005	Normal cornea contains heparan sulfate to prevent the release of potent angiogenic cytokines, such as basic fibroblast growth factor (bFGF) from the Bowman"s layer.	Heparitin Sulfate	23-38	fibroblast growth factor 2	Homo sapiens	102-132
17216117-4	2005	Normal cornea contains heparan sulfate to prevent the release of potent angiogenic cytokines, such as basic fibroblast growth factor (bFGF) from the Bowman"s layer.	Heparitin Sulfate	23-38	fibroblast growth factor 2	Homo sapiens	134-138
16141236-0	2005	pH-specific sequestration of phosphoglucose isomerase/autocrine motility factor by fibronectin and heparan sulphate.	Heparitin Sulfate	99-115	glucose-6-phosphate isomerase	Homo sapiens	29-53
16141236-0	2005	pH-specific sequestration of phosphoglucose isomerase/autocrine motility factor by fibronectin and heparan sulphate.	Heparitin Sulfate	99-115	glucose-6-phosphate isomerase	Homo sapiens	54-79
16141236-7	2005	Heparan sulphate does not affect cell association of PGI/AMF at neutral pH but enhances the FN-independent cell surface association of PGI/AMF at acid pH identifying two distinct mechanisms for PGI/AMF sequestration under acidic conditions.	Heparitin Sulfate	0-16	fibronectin 1	Homo sapiens	92-94
16176946-5	2005	Epistasis analysis suggests that heparan sulfate (HS) attached to SDN-1 can regulate guidance signaling by the Slit/Robo pathway.	Heparitin Sulfate	33-48	Syndecan;putative syndecan	Caenorhabditis elegans	66-71
16176946-5	2005	Epistasis analysis suggests that heparan sulfate (HS) attached to SDN-1 can regulate guidance signaling by the Slit/Robo pathway.	Heparitin Sulfate	50-52	Syndecan;putative syndecan	Caenorhabditis elegans	66-71
16181411-1	2005	The second Ig module (IgII) of the neural cell adhesion molecule (NCAM) is known to bind to the first Ig module (IgI) of NCAM (so-called homophilic binding) and to interact with heparan sulfate and chondroitin sulfate glycoconjugates.	Heparitin Sulfate	178-193	neural cell adhesion molecule 1	Homo sapiens	35-64
16181411-1	2005	The second Ig module (IgII) of the neural cell adhesion molecule (NCAM) is known to bind to the first Ig module (IgI) of NCAM (so-called homophilic binding) and to interact with heparan sulfate and chondroitin sulfate glycoconjugates.	Heparitin Sulfate	178-193	neural cell adhesion molecule 1	Homo sapiens	66-70
15947088-0	2005	Functional abnormalities of heparan sulfate in mucopolysaccharidosis-I are associated with defective biologic activity of FGF-2 on human multipotent progenitor cells.	Heparitin Sulfate	28-43	fibroblast growth factor 2	Homo sapiens	122-127
15947088-1	2005	In mucopolysaccharidosis-I (MPS-I), alpha-L-iduronidase deficiency leads to progressive heparan sulfate (HS) and dermatan sulfate (DS) glycosaminoglycan (GAG) accumulation.	Heparitin Sulfate	88-103	alpha-L-iduronidase	Homo sapiens	36-55
15947088-1	2005	In mucopolysaccharidosis-I (MPS-I), alpha-L-iduronidase deficiency leads to progressive heparan sulfate (HS) and dermatan sulfate (DS) glycosaminoglycan (GAG) accumulation.	Heparitin Sulfate	105-107	alpha-L-iduronidase	Homo sapiens	36-55
16141236-7	2005	Heparan sulphate does not affect cell association of PGI/AMF at neutral pH but enhances the FN-independent cell surface association of PGI/AMF at acid pH identifying two distinct mechanisms for PGI/AMF sequestration under acidic conditions.	Heparitin Sulfate	0-16	glucose-6-phosphate isomerase	Homo sapiens	139-142
16141236-7	2005	Heparan sulphate does not affect cell association of PGI/AMF at neutral pH but enhances the FN-independent cell surface association of PGI/AMF at acid pH identifying two distinct mechanisms for PGI/AMF sequestration under acidic conditions.	Heparitin Sulfate	0-16	glucose-6-phosphate isomerase	Homo sapiens	135-138
16141236-7	2005	Heparan sulphate does not affect cell association of PGI/AMF at neutral pH but enhances the FN-independent cell surface association of PGI/AMF at acid pH identifying two distinct mechanisms for PGI/AMF sequestration under acidic conditions.	Heparitin Sulfate	0-16	glucose-6-phosphate isomerase	Homo sapiens	139-142
15853773-2	2005	GLCE (D-glucuronyl C5-epimerase), an enzyme responsible for the epimerization of D-glucuronic acid into L-iduronic acid of HS, endows the nascent polysaccharide chain with the ability to bind to growth factors and cytokines.	Heparitin Sulfate	123-125	glucuronic acid epimerase	Homo sapiens	0-4
16027124-10	2005	It is therefore likely that a heparin-like domain of heparan sulfate/heparin forms a complex with VEGF165 and VEGFR-2 via the exon 7-encoded region, thereby enhancing VEGF165-dependent signaling.	Heparitin Sulfate	53-68	kinase insert domain receptor	Homo sapiens	110-117
15996656-3	2005	VEGF isoforms have different affinities for heparan sulphate as well as for VEGF receptors, and may play distinct roles in vascular development.	Heparitin Sulfate	44-60	vascular endothelial growth factor A	Bos taurus	0-4
16027123-2	2005	The biological activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) is modulated by the sulfated glycosaminoglycans (GAGs) heparan sulfate and heparin.	Heparitin Sulfate	140-155	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	77-83
16127145-7	2005	Deposition of the anti-MCP-1 Ab in rat kidneys resulted from its binding to heparan sulfate-immobilized MCP-1, as demonstrated by the detection of MCP-1 in both pull-down and immunoprecipitation assays.	Heparitin Sulfate	76-91	C-C motif chemokine ligand 2	Rattus norvegicus	23-28
16127145-7	2005	Deposition of the anti-MCP-1 Ab in rat kidneys resulted from its binding to heparan sulfate-immobilized MCP-1, as demonstrated by the detection of MCP-1 in both pull-down and immunoprecipitation assays.	Heparitin Sulfate	76-91	C-C motif chemokine ligand 2	Rattus norvegicus	104-109
16127145-7	2005	Deposition of the anti-MCP-1 Ab in rat kidneys resulted from its binding to heparan sulfate-immobilized MCP-1, as demonstrated by the detection of MCP-1 in both pull-down and immunoprecipitation assays.	Heparitin Sulfate	76-91	C-C motif chemokine ligand 2	Rattus norvegicus	104-109
16127145-8	2005	We conclude that induction of chemokines, specifically MCP-1, in TIN corresponds with leukocyte infiltration and that the anti-MCP-1 Ab formed an immune complex with heparan sulfate-immobilized MCP-1 in the kidney.	Heparitin Sulfate	166-181	C-C motif chemokine ligand 2	Rattus norvegicus	127-132
16127145-8	2005	We conclude that induction of chemokines, specifically MCP-1, in TIN corresponds with leukocyte infiltration and that the anti-MCP-1 Ab formed an immune complex with heparan sulfate-immobilized MCP-1 in the kidney.	Heparitin Sulfate	166-181	C-C motif chemokine ligand 2	Rattus norvegicus	127-132
15853773-2	2005	GLCE (D-glucuronyl C5-epimerase), an enzyme responsible for the epimerization of D-glucuronic acid into L-iduronic acid of HS, endows the nascent polysaccharide chain with the ability to bind to growth factors and cytokines.	Heparitin Sulfate	123-125	glucuronic acid epimerase	Homo sapiens	6-31
15853773-8	2005	The data obtained are consistent with the idea that the beta-catenin-TCF4 transactivation pathway plays a major role in modulating GLCE expression, thus contributing to the regulation of HS biosynthesis and its structural organization.	Heparitin Sulfate	187-189	transcription factor 4	Homo sapiens	69-73
15853773-8	2005	The data obtained are consistent with the idea that the beta-catenin-TCF4 transactivation pathway plays a major role in modulating GLCE expression, thus contributing to the regulation of HS biosynthesis and its structural organization.	Heparitin Sulfate	187-189	glucuronic acid epimerase	Homo sapiens	131-135
16116207-6	2005	Soluble heparin and heparan sulfate but not chondroitin sulfates greatly diminished cytokine induction through inhibition of capsid binding to THP-1 macrophages.	Heparitin Sulfate	20-35	GLI family zinc finger 2	Homo sapiens	143-148
16139226-4	2005	FGF receptor accompanies syndecan along the syntenin-mediated recycling pathway, in a heparan sulfate- and FGF-dependent manner.	Heparitin Sulfate	86-101	syndecan 1	Homo sapiens	25-33
16139226-4	2005	FGF receptor accompanies syndecan along the syntenin-mediated recycling pathway, in a heparan sulfate- and FGF-dependent manner.	Heparitin Sulfate	86-101	syndecan binding protein	Homo sapiens	44-52
16156786-1	2005	The growth factor pleiotrophin (PTN) has been reported to bind heparan sulfate and nucleolin, two components of the cell surface implicated in the attachment of HIV-1 particles to cells.	Heparitin Sulfate	63-78	pleiotrophin	Homo sapiens	18-30
16156786-1	2005	The growth factor pleiotrophin (PTN) has been reported to bind heparan sulfate and nucleolin, two components of the cell surface implicated in the attachment of HIV-1 particles to cells.	Heparitin Sulfate	63-78	pleiotrophin	Homo sapiens	32-35
16009360-6	2005	Structural analysis of heparan sulfate from wild-type and morpholino antisense "knockdown" embryos suggests that HS6ST-1 and HS6ST-2 have similar biochemical activity.	Heparitin Sulfate	23-38	heparan sulfate 6-O-sulfotransferase 1a	Danio rerio	113-120
15975901-1	2005	The heparan sulfate proteoglycan agrin and adhesion molecules are key players in the formation of neuronal and immune synapses that evolved for efficient communication at the sites of cell-cell contact.	Heparitin Sulfate	4-19	agrin	Homo sapiens	33-38
16056228-6	2005	Thus, endothelial heparan sulfate has three functions in inflammation: by acting as a ligand for L-selectin during neutrophil rolling; in chemokine transcytosis; and by binding and presenting chemokines at the lumenal surface of the endothelium.	Heparitin Sulfate	18-33	selectin, lymphocyte	Mus musculus	97-107
15980072-3	2005	We have used BIAcore technology to investigate fibrillin-1 interactions with heparin and with heparin saccharides that are analogous to S-domains of heparan sulfate.	Heparitin Sulfate	149-164	fibrillin 1	Homo sapiens	47-58
16009360-1	2005	Heparan sulfate proteoglycans are important modulators of growth factor signaling in a variety of patterning processes.	Heparitin Sulfate	0-15	nerve growth factor receptor a (TNFR superfamily, member 16)	Danio rerio	58-71
16009360-6	2005	Structural analysis of heparan sulfate from wild-type and morpholino antisense "knockdown" embryos suggests that HS6ST-1 and HS6ST-2 have similar biochemical activity.	Heparitin Sulfate	23-38	heparan sulfate 6-O-sulfotransferase 2	Danio rerio	125-132
16009360-8	2005	Our finding that HS6ST-2 is required for the branching morphogenesis of the caudal vein is the first in vivo evidence for an essential role of a gene encoding a heparan sulfate modifying enzyme in vertebrate angiogenesis.	Heparitin Sulfate	161-176	heparan sulfate 6-O-sulfotransferase 2	Danio rerio	17-24
15985216-7	2005	Although bFGF was found to bind more strongly to heparin-Sepharose than endostatin, the latter, but not the former, displaced protamine from heparin in solution, which supports the notion that endostatin can compete with bFGF for binding to heparan sulfate in vivo.	Heparitin Sulfate	241-256	collagen type XVIII alpha 1 chain	Homo sapiens	193-203
15985216-2	2005	Here, we used human endothelial cells from lung capillaries to investigate if endostatin competes with the proangiogenic growth factors, bFGF and VEGF, for binding to costimulatory heparan sulfate molecules.	Heparitin Sulfate	181-196	collagen type XVIII alpha 1 chain	Homo sapiens	78-88
16020517-1	2005	Mutant mice bearing a targeted disruption of the heparan sulfate (HS) modifying enzyme GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) exhibit severe developmental defects of the forebrain and forebrain-derived structures, including cerebral hypoplasia, lack of olfactory bulbs, eye defects and axon guidance errors.	Heparitin Sulfate	49-64	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	130-135
16020517-1	2005	Mutant mice bearing a targeted disruption of the heparan sulfate (HS) modifying enzyme GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) exhibit severe developmental defects of the forebrain and forebrain-derived structures, including cerebral hypoplasia, lack of olfactory bulbs, eye defects and axon guidance errors.	Heparitin Sulfate	66-68	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	130-135
16020517-3	2005	We show that properly synthesized heparan sulfate is required for the normal development of the brain and face, and that Ndst1 is a modifier of heparan sulfate-dependent growth factor/morphogen signalling in those tissues.	Heparitin Sulfate	144-159	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	121-126
16020517-4	2005	Among the multiple heparan sulfate-binding factors potentially affected in Ndst1 mutant embryos, the facial phenotypes are consistent with impaired sonic hedgehog (Shh) and fibroblast growth factor (Fgf) interaction with mutant heparan sulfate.	Heparitin Sulfate	19-34	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	75-80
16020517-4	2005	Among the multiple heparan sulfate-binding factors potentially affected in Ndst1 mutant embryos, the facial phenotypes are consistent with impaired sonic hedgehog (Shh) and fibroblast growth factor (Fgf) interaction with mutant heparan sulfate.	Heparitin Sulfate	19-34	sonic hedgehog	Mus musculus	164-167
16020517-4	2005	Among the multiple heparan sulfate-binding factors potentially affected in Ndst1 mutant embryos, the facial phenotypes are consistent with impaired sonic hedgehog (Shh) and fibroblast growth factor (Fgf) interaction with mutant heparan sulfate.	Heparitin Sulfate	228-243	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	75-80
16137227-0	2005	Transplantation of human umbilical cord blood cells benefits an animal model of Sanfilippo syndrome type B. Sanfilippo syndrome type B is caused by alpha-N-acetylglucosaminidase (Naglu) enzyme deficiency leading to an accumulation of undegraded heparan sulfate, a glycosaminoglycan (GAG).	Heparitin Sulfate	245-260	N-acetyl-alpha-glucosaminidase	Homo sapiens	179-184
15952792-11	2005	These observations demonstrate that the short C-terminal region of VEGF-F functions fully as the active heparin-binding domain and the corresponding peptide specifically blocks VEGF-A165, thus suggesting that the C-terminal heparin-binding region of VEGF-F recognizes similar heparin/heparan sulfate molecules as VEGF-A165.	Heparitin Sulfate	284-299	vascular endothelial growth factor A	Homo sapiens	67-71
15917223-0	2005	Identification of L-selectin binding heparan sulfates attached to collagen type XVIII.	Heparitin Sulfate	37-53	selectin, lymphocyte	Mus musculus	18-28
15917223-6	2005	Furthermore, we show that L-selectin only binds a subset of renal heparan sulfates, attached to a collagen type XVIII protein backbone and predominantly present in medullary tubular and vascular basement membranes.	Heparitin Sulfate	66-82	selectin, lymphocyte	Mus musculus	26-36
15917223-9	2005	Based on our results and the accepted model of heparan sulfate domain organization, we propose a model for the interaction of L-selectin with heparan sulfate glycosaminoglycan chains.	Heparitin Sulfate	47-62	selectin, lymphocyte	Mus musculus	126-136
15917224-9	2005	Changes in plasmin activity have been observed previously at sites of TSG-6 expression, and the results presented here suggest that TSG-6 is likely to contribute to matrix remodeling, at least in part, through down-regulation of the protease network, especially in locations containing heparin/heparan sulfate proteoglycans.	Heparitin Sulfate	294-309	plasminogen	Homo sapiens	11-18
15917224-9	2005	Changes in plasmin activity have been observed previously at sites of TSG-6 expression, and the results presented here suggest that TSG-6 is likely to contribute to matrix remodeling, at least in part, through down-regulation of the protease network, especially in locations containing heparin/heparan sulfate proteoglycans.	Heparitin Sulfate	294-309	TNF alpha induced protein 6	Homo sapiens	132-137
15983219-2	2005	In the present study, we showed that the expression of heparanase-1 (HPR1), a heparan sulfate-degrading endoglycosidase, was upregulated in the renal epithelial cells in the kidney with diabetic nephropathy.	Heparitin Sulfate	78-93	heparanase	Homo sapiens	55-67
15983219-2	2005	In the present study, we showed that the expression of heparanase-1 (HPR1), a heparan sulfate-degrading endoglycosidase, was upregulated in the renal epithelial cells in the kidney with diabetic nephropathy.	Heparitin Sulfate	78-93	heparanase	Homo sapiens	69-73
15983219-5	2005	Induction of HPR1 expression by high glucose led to decreased cell surface heparan sulfate expression.	Heparitin Sulfate	75-90	heparanase	Homo sapiens	13-17
15983219-6	2005	HPR1 inhibitors were able to restore cell surface heparan sulfate expression.	Heparitin Sulfate	50-65	heparanase	Homo sapiens	0-4
15983219-8	2005	Our studies suggest that loss of heparan sulfate in the GBM with diabetic nephropathy is attributable to accelerated heparan sulfate degradation by increased HPR1 expression.	Heparitin Sulfate	33-48	heparanase	Homo sapiens	158-162
15972650-2	2005	The cellular ligand for NKp30 has remained elusive, although evidence that membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported.	Heparitin Sulfate	95-110	natural cytotoxicity triggering receptor 3	Homo sapiens	185-190
15972650-2	2005	The cellular ligand for NKp30 has remained elusive, although evidence that membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported.	Heparitin Sulfate	112-114	natural cytotoxicity triggering receptor 3	Homo sapiens	185-190
15919224-6	2005	We show that Hlp/LBP, besides laminin, also binds heparin and heparan sulfate.	Heparitin Sulfate	62-77	lipopolysaccharide binding protein	Homo sapiens	17-20
15913650-0	2005	The oligomeric structure of vaccinia viral envelope protein A27L is essential for binding to heparin and heparan sulfates on cell surfaces: a structural and functional approach using site-specific mutagenesis.	Heparitin Sulfate	105-121	IMV surface protein	Vaccinia virus	60-64
15913650-11	2005	Thus, we conclude that the leucine residues, in particular Leu51 and Leu54, sustain the hydrophobic core structure that is essential for the biological function of vaccinia virus envelope protein A27L, binding to cell-surface heparan sulfate.	Heparitin Sulfate	226-241	IMV surface protein	Vaccinia virus	196-200
15994953-1	2005	Heparanase is an enzyme that cleaves heparan sulfate and through this activity promotes tumor growth, angiogenesis, invasion, and metastasis in several tumor types.	Heparitin Sulfate	37-52	heparanase	Homo sapiens	0-10
15925496-2	2005	Previously, using in vitro models of branching morphogenesis, we demonstrated that BMP2 signals via its intracellular effectors, SMAD1 and SMAD4, to control UB cell proliferation and branching in a manner modulated by Glypican-3 (GPC3), a cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	252-267	bone morphogenetic protein 2	Mus musculus	83-87
15925496-2	2005	Previously, using in vitro models of branching morphogenesis, we demonstrated that BMP2 signals via its intracellular effectors, SMAD1 and SMAD4, to control UB cell proliferation and branching in a manner modulated by Glypican-3 (GPC3), a cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	252-267	glypican 3	Mus musculus	218-228
15944760-1	2005	Heparanase is endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane.	Heparitin Sulfate	44-59	heparanase	Homo sapiens	0-10
15797855-0	2005	Heparan sulfate targets the HIV-1 envelope glycoprotein gp120 coreceptor binding site.	Heparitin Sulfate	0-15	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	56-61
15958608-1	2005	Fibroblast growth factor-2 (FGF-2) is a potent angiogenic cytokine that is dependent on heparan sulfate for its biological activity.	Heparitin Sulfate	88-103	fibroblast growth factor 2	Homo sapiens	0-26
15958608-1	2005	Fibroblast growth factor-2 (FGF-2) is a potent angiogenic cytokine that is dependent on heparan sulfate for its biological activity.	Heparitin Sulfate	88-103	fibroblast growth factor 2	Homo sapiens	28-33
15958608-3	2005	Using a unique molecular probe, FR1c-Ap, which consisted of a soluble FGF receptor 1 isoform IIIc covalently linked to an alkaline phosphatase moiety, the distribution of heparan sulfate that had the ability to support the formation of a heparan sulfate/FGF-2/FGFR1 isoform IIIc alkaline phosphatase heparan sulfate construct complex was determined.	Heparitin Sulfate	171-186	fibroblast growth factor 2	Homo sapiens	254-259
15958608-3	2005	Using a unique molecular probe, FR1c-Ap, which consisted of a soluble FGF receptor 1 isoform IIIc covalently linked to an alkaline phosphatase moiety, the distribution of heparan sulfate that had the ability to support the formation of a heparan sulfate/FGF-2/FGFR1 isoform IIIc alkaline phosphatase heparan sulfate construct complex was determined.	Heparitin Sulfate	171-186	fibroblast growth factor receptor 1	Homo sapiens	260-265
15958608-7	2005	Double-staining techniques showed that heparan sulfate was found predominantly at the basal aspect of the endothelium and suggested that syndecan-3 might function as one of the proteoglycans involved in FGF-2 signaling in the endothelium.	Heparitin Sulfate	39-54	syndecan 3	Homo sapiens	137-147
15958608-7	2005	Double-staining techniques showed that heparan sulfate was found predominantly at the basal aspect of the endothelium and suggested that syndecan-3 might function as one of the proteoglycans involved in FGF-2 signaling in the endothelium.	Heparitin Sulfate	39-54	fibroblast growth factor 2	Homo sapiens	203-208
15797855-2	2005	HIV gp120 also binds to other cell surface components, including heparan sulfate (HS), a sulfated polysaccharide whose wide interactive properties are exploited by many pathogens for attachment and concentration at the cell surface.	Heparitin Sulfate	65-80	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	4-9
15797855-2	2005	HIV gp120 also binds to other cell surface components, including heparan sulfate (HS), a sulfated polysaccharide whose wide interactive properties are exploited by many pathogens for attachment and concentration at the cell surface.	Heparitin Sulfate	82-84	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	4-9
15797855-5	2005	We then showed that HS binding interface on gp120 comprised, in addition to the well characterized V3 loop, a CD4-induced epitope.	Heparitin Sulfate	20-22	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	44-49
15797855-5	2005	We then showed that HS binding interface on gp120 comprised, in addition to the well characterized V3 loop, a CD4-induced epitope.	Heparitin Sulfate	20-22	CD4 molecule	Homo sapiens	110-113
16026543-3	2005	The EXT1 and EXT2 genes are glycosyltransferases that function as hetero-oligomers in the Golgi to add repeating glycosaminoglycans (GAGs) to heparan sulfate (HS) chains.	Heparitin Sulfate	142-157	exostosin glycosyltransferase 1	Homo sapiens	4-8
15806157-0	2005	A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer.	Heparitin Sulfate	13-28	heparanase	Mus musculus	53-63
15806157-3	2005	Heparanase is a matrix-degrading enzyme that cleaves heparan sulfate side chains from the core proteoglycans, thus liberating such HS-binding proteins, as well as potentially contributing to extracellular matrix degradation.	Heparitin Sulfate	53-68	heparanase	Mus musculus	0-10
15806157-6	2005	A sulfated oligosaccharide mimetic of heparan sulfate, PI-88, was used to inhibit simultaneously both heparanase activity and HS effector functions.	Heparitin Sulfate	38-53	heparanase	Mus musculus	102-112
15846369-6	2005	In agreement, mutation of three lysines in a putative heparin sulfate-binding motif, which is not part of the TNF fold, destroys interaction with HSPG, while binding to BCMA is unaffected.	Heparitin Sulfate	54-69	syndecan 2	Homo sapiens	146-150
16020273-0	2005	Increased leukocyte-endothelial interactions in syndecan-1-deficient mice involve heparan sulfate-dependent and -independent steps.	Heparitin Sulfate	82-97	syndecan 1	Mus musculus	48-58
16020273-8	2005	Its heparan sulfate chains play different roles in this process in unstimulated endothelia compared to TNF-alpha-stimulated endothelia.	Heparitin Sulfate	4-19	tumor necrosis factor	Mus musculus	103-112
15935280-2	2005	Interaction of transglutaminase with heparin might mimic the physiological binding to membrane heparan sulfates, accounting for the limited but significant fraction of enzyme exposed at cell surface to crosslink ECM proteins.	Heparitin Sulfate	95-111	multimerin 1	Homo sapiens	212-215
16026543-3	2005	The EXT1 and EXT2 genes are glycosyltransferases that function as hetero-oligomers in the Golgi to add repeating glycosaminoglycans (GAGs) to heparan sulfate (HS) chains.	Heparitin Sulfate	142-157	exostosin glycosyltransferase 2	Homo sapiens	13-17
16026543-3	2005	The EXT1 and EXT2 genes are glycosyltransferases that function as hetero-oligomers in the Golgi to add repeating glycosaminoglycans (GAGs) to heparan sulfate (HS) chains.	Heparitin Sulfate	159-161	exostosin glycosyltransferase 1	Homo sapiens	4-8
16026543-3	2005	The EXT1 and EXT2 genes are glycosyltransferases that function as hetero-oligomers in the Golgi to add repeating glycosaminoglycans (GAGs) to heparan sulfate (HS) chains.	Heparitin Sulfate	159-161	exostosin glycosyltransferase 2	Homo sapiens	13-17
16021525-1	2005	Perlecan is a modular heparan sulphate and/or chondroitin sulphate substituted proteoglycan of basement membrane, vascular tissues and cartilage.	Heparitin Sulfate	22-38	perlecan	Ovis aries	0-8
15760902-0	2005	Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.	Heparitin Sulfate	47-62	heparanase	Homo sapiens	102-112
15872080-5	2005	Approximately 40% of the perlecan synthesized by Hspg2(Delta)(3/)(Delta)(3) fibroblasts was substituted with heparin sulfate and 60% was substituted with chondroitin sulfate.	Heparitin Sulfate	109-124	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	49-54
15760902-1	2005	The endo-beta-glucuronidase, heparanase, is an enzyme that cleaves heparan sulfate at specific intra-chain sites, yielding heparan sulfate fragments with appreciable size and biological activities.	Heparitin Sulfate	67-82	heparanase	Homo sapiens	29-39
15760902-1	2005	The endo-beta-glucuronidase, heparanase, is an enzyme that cleaves heparan sulfate at specific intra-chain sites, yielding heparan sulfate fragments with appreciable size and biological activities.	Heparitin Sulfate	123-138	heparanase	Homo sapiens	29-39
15760902-4	2005	In an attempt to identify the protein motif that would serve as a target for the development of heparanase inhibitors, we looked for protein domains that mediate the interaction of heparanase with its heparan sulfate substrate.	Heparitin Sulfate	201-216	heparanase	Homo sapiens	181-191
15760902-7	2005	Moreover, the peptide inhibited heparanase enzymatic activity in a dose-responsive manner, presumably through competition with the heparan sulfate substrate.	Heparitin Sulfate	131-146	heparanase	Homo sapiens	32-42
15760902-11	2005	The two heparin/heparan sulfate recognition domains are potentially attractive targets for the development of heparanase inhibitors.	Heparitin Sulfate	16-31	heparanase	Homo sapiens	110-120
15899837-3	2005	Syndecan-1 is a heparan sulfate proteoglycan, expressed on the surface of mammary epithelial cells and known to regulate many biological processes, including cytoskeletal organization, growth factor signaling, and cell-cell adhesion.	Heparitin Sulfate	16-31	syndecan 1	Homo sapiens	0-10
15968398-3	2005	In this study, we report that platelets express syndecan-4, an antithrombin-binding cell surface heparan sulphate proteoglycan, whose ligation with antithrombin inhibits activated platelet-dependent superoxide anion release from neutrophils by the limitation of adenosine diphosphate and adenosine triphosphate secretion in activated platelets.	Heparitin Sulfate	97-113	syndecan 4	Homo sapiens	48-58
15968398-3	2005	In this study, we report that platelets express syndecan-4, an antithrombin-binding cell surface heparan sulphate proteoglycan, whose ligation with antithrombin inhibits activated platelet-dependent superoxide anion release from neutrophils by the limitation of adenosine diphosphate and adenosine triphosphate secretion in activated platelets.	Heparitin Sulfate	97-113	serpin family C member 1	Homo sapiens	63-75
15968398-3	2005	In this study, we report that platelets express syndecan-4, an antithrombin-binding cell surface heparan sulphate proteoglycan, whose ligation with antithrombin inhibits activated platelet-dependent superoxide anion release from neutrophils by the limitation of adenosine diphosphate and adenosine triphosphate secretion in activated platelets.	Heparitin Sulfate	97-113	serpin family C member 1	Homo sapiens	148-160
15604198-0	2005	Heparan sulfate depletion amplifies TNF-alpha-induced protein leakage in an in vitro model of protein-losing enteropathy.	Heparitin Sulfate	0-15	tumor necrosis factor	Homo sapiens	36-45
15886101-0	2005	The heparan sulfate proteoglycans Dally-like and Syndecan have distinct functions in axon guidance and visual-system assembly in Drosophila.	Heparitin Sulfate	4-19	Syndecan	Drosophila melanogaster	49-57
15886101-2	2005	In C. elegans, zebrafish, and the mouse, heparan sulfate (HS) biosynthesis is required for normal axon guidance, and mutations affecting Syndecan (Sdc), a transmembrane HSPG, disrupt axon guidance in Drosophila embryos.	Heparitin Sulfate	41-56	Syndecan	Drosophila melanogaster	147-150
15886101-2	2005	In C. elegans, zebrafish, and the mouse, heparan sulfate (HS) biosynthesis is required for normal axon guidance, and mutations affecting Syndecan (Sdc), a transmembrane HSPG, disrupt axon guidance in Drosophila embryos.	Heparitin Sulfate	58-60	Syndecan	Drosophila melanogaster	137-145
15886101-2	2005	In C. elegans, zebrafish, and the mouse, heparan sulfate (HS) biosynthesis is required for normal axon guidance, and mutations affecting Syndecan (Sdc), a transmembrane HSPG, disrupt axon guidance in Drosophila embryos.	Heparitin Sulfate	58-60	Syndecan	Drosophila melanogaster	147-150
15886101-2	2005	In C. elegans, zebrafish, and the mouse, heparan sulfate (HS) biosynthesis is required for normal axon guidance, and mutations affecting Syndecan (Sdc), a transmembrane HSPG, disrupt axon guidance in Drosophila embryos.	Heparitin Sulfate	58-60	syndecan 2	Mus musculus	169-173
15604198-1	2005	Protein-losing enteropathy (PLE), the excessive loss of plasma proteins through the intestine, often correlates with the episodic loss of heparan sulfate (HS) proteoglycans (HSPG) from the basolateral surface of intestinal epithelial cells.	Heparitin Sulfate	155-157	syndecan 2	Homo sapiens	174-178
15604198-8	2005	Coincubation of TNF-alpha with soluble HS or heparin abolished these synergistic effects.	Heparitin Sulfate	39-41	tumor necrosis factor	Homo sapiens	16-25
15604198-9	2005	Loss of basolateral HS directly causes protein leakage and amplifies the effects of the proinflammatory cytokine TNF-alpha.	Heparitin Sulfate	20-22	tumor necrosis factor	Homo sapiens	113-122
15843578-7	2005	Our results also show that syndecan-1 ectodomains bind to the CC chemokines (CCL7, CCL11, and CCL17) implicated in allergic diseases, inhibit CC chemokine-mediated T cell migration, and suppress allergen-induced accumulation of Th2 cells in the lung through their heparan sulfate chains.	Heparitin Sulfate	264-279	syndecan 1	Mus musculus	27-37
15728209-8	2005	Osteoprotegerin-induced deactivation of monocyte chemotaxis toward different chemokines is due to interaction of osteoprotegerin with heparan sulfate and chondroitin sulfate.	Heparitin Sulfate	134-149	TNF receptor superfamily member 11b	Homo sapiens	0-15
15728209-8	2005	Osteoprotegerin-induced deactivation of monocyte chemotaxis toward different chemokines is due to interaction of osteoprotegerin with heparan sulfate and chondroitin sulfate.	Heparitin Sulfate	134-149	TNF receptor superfamily member 11b	Homo sapiens	113-128
15854029-4	2005	Here we demonstrated that syndecan-4, a transmembrane heparan sulfate (HS) proteoglycan, known to bind FN, is also required for fibroblast invasive migration of a fibrin/FN gel.	Heparitin Sulfate	54-69	syndecan 4	Homo sapiens	26-36
15854029-4	2005	Here we demonstrated that syndecan-4, a transmembrane heparan sulfate (HS) proteoglycan, known to bind FN, is also required for fibroblast invasive migration of a fibrin/FN gel.	Heparitin Sulfate	71-73	syndecan 4	Homo sapiens	26-36
15854029-4	2005	Here we demonstrated that syndecan-4, a transmembrane heparan sulfate (HS) proteoglycan, known to bind FN, is also required for fibroblast invasive migration of a fibrin/FN gel.	Heparitin Sulfate	71-73	fibronectin 1	Homo sapiens	103-105
15857886-3	2005	Molecular studies demonstrated binding of the endostatin domain to heparan sulfate and to BM components like laminin and perlecan, but the functional role of these interactions in vivo remains unknown.	Heparitin Sulfate	67-82	collagen type XVIII alpha 1 chain	Homo sapiens	46-56
15843578-7	2005	Our results also show that syndecan-1 ectodomains bind to the CC chemokines (CCL7, CCL11, and CCL17) implicated in allergic diseases, inhibit CC chemokine-mediated T cell migration, and suppress allergen-induced accumulation of Th2 cells in the lung through their heparan sulfate chains.	Heparitin Sulfate	264-279	chemokine (C-C motif) ligand 7	Mus musculus	77-81
15878740-5	2005	Minor amounts of particular a heparan sulfate (&lt; 5% of the total arterial glycosaminoglycans) with high anticoagulant activity were also observed, as assessed by its retention on an antithrombin-affinity column.	Heparitin Sulfate	30-45	serpin family C member 1	Homo sapiens	185-197
15878761-2	2005	Heparanase is the endo-glucuronidase enzyme that specifically cleaves heparan sulfate, the important modulator of extracellular matrix, and related to invasion of tumor cells.	Heparitin Sulfate	70-85	heparanase	Homo sapiens	0-10
15710745-0	2005	Heparan sulfate regulates the antiangiogenic activity of endothelial monocyte-activating polypeptide-II at acidic pH.	Heparitin Sulfate	0-15	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	57-103
15710745-8	2005	Analysis using mutant EMAP II proteins demonstrated that heparan sulfate was essential for the enhanced binding and EMAP II function to endothelial cells at acidic pH.	Heparitin Sulfate	57-72	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	22-29
15710745-8	2005	Analysis using mutant EMAP II proteins demonstrated that heparan sulfate was essential for the enhanced binding and EMAP II function to endothelial cells at acidic pH.	Heparitin Sulfate	57-72	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	116-123
15710745-10	2005	In the endothelial cell, heparan sulfate may regulate the function of EMAP II released from the tumor cell in hypoxic condition.	Heparitin Sulfate	25-40	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	70-77
15878740-8	2005	One is based on antithrombin activation by the heparan sulfate expressed by the endothelial cells.	Heparitin Sulfate	47-62	serpin family C member 1	Homo sapiens	16-28
15810091-1	2005	AIM: Human heparanase is an endo-D-glucuronidase that degrades heparan sulfate/heparin and has been implicated in a variety of biological processes.	Heparitin Sulfate	63-78	heparanase	Homo sapiens	11-21
15819887-8	2005	Pretreatment of the cells with heparitinases I and III prevented the tyrosine phosphorylation of syndecan-4, which suggests that the heparan sulfate-dependent binding of SDF-1 to this proteoglycan is involved.	Heparitin Sulfate	133-148	syndecan 4	Homo sapiens	97-107
15677459-0	2005	The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.	Heparitin Sulfate	149-164	amyloid beta (A4) precursor protein	Mus musculus	4-29
15677459-0	2005	The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.	Heparitin Sulfate	149-164	amyloid beta (A4) precursor-like protein 2	Mus musculus	74-79
15677459-0	2005	The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.	Heparitin Sulfate	149-164	glypican 1	Mus musculus	138-148
15677459-1	2005	Processing of the recycling proteoglycan glypican-1 involves the release of its heparan sulfate chains by copper ion- and nitric oxide-catalyzed ascorbate-triggered autodegradation.	Heparitin Sulfate	80-95	glypican 1	Mus musculus	41-51
15677459-2	2005	The Alzheimer disease amyloid precursor protein (APP) and its paralogue, the amyloid precursor-like protein 2 (APLP2), contain copper ion-, zinc ion-, and heparan sulfate-binding domains.	Heparitin Sulfate	155-170	amyloid beta (A4) precursor protein	Mus musculus	22-47
15677459-2	2005	The Alzheimer disease amyloid precursor protein (APP) and its paralogue, the amyloid precursor-like protein 2 (APLP2), contain copper ion-, zinc ion-, and heparan sulfate-binding domains.	Heparitin Sulfate	155-170	amyloid beta (A4) precursor-like protein 2	Mus musculus	77-109
15677459-2	2005	The Alzheimer disease amyloid precursor protein (APP) and its paralogue, the amyloid precursor-like protein 2 (APLP2), contain copper ion-, zinc ion-, and heparan sulfate-binding domains.	Heparitin Sulfate	155-170	amyloid beta (A4) precursor-like protein 2	Mus musculus	111-116
15677459-6	2005	These observation identify a functional relationship between the heparan sulfate and copper ion binding activities of APP/APLP2 in their modulation of the nitroxyl anion-catalyzed heparan sulfate degradation in glypican-1.	Heparitin Sulfate	65-80	amyloid beta (A4) precursor-like protein 2	Mus musculus	122-127
15677459-6	2005	These observation identify a functional relationship between the heparan sulfate and copper ion binding activities of APP/APLP2 in their modulation of the nitroxyl anion-catalyzed heparan sulfate degradation in glypican-1.	Heparitin Sulfate	65-80	glypican 1	Mus musculus	211-221
15677459-6	2005	These observation identify a functional relationship between the heparan sulfate and copper ion binding activities of APP/APLP2 in their modulation of the nitroxyl anion-catalyzed heparan sulfate degradation in glypican-1.	Heparitin Sulfate	180-195	amyloid beta (A4) precursor-like protein 2	Mus musculus	122-127
15677459-6	2005	These observation identify a functional relationship between the heparan sulfate and copper ion binding activities of APP/APLP2 in their modulation of the nitroxyl anion-catalyzed heparan sulfate degradation in glypican-1.	Heparitin Sulfate	180-195	glypican 1	Mus musculus	211-221
15659389-1	2005	Heparanase is an endo-beta-D-glucuronidase that degrades heparan sulfate in the extracellular matrix and cell surfaces.	Heparitin Sulfate	57-72	glucuronidase beta	Homo sapiens	22-42
15819887-8	2005	Pretreatment of the cells with heparitinases I and III prevented the tyrosine phosphorylation of syndecan-4, which suggests that the heparan sulfate-dependent binding of SDF-1 to this proteoglycan is involved.	Heparitin Sulfate	133-148	C-X-C motif chemokine ligand 12	Homo sapiens	170-175
15819887-9	2005	Finally, by reducing syndecan-4 expression using RNA interference or by pretreating the cells with heparitinase I and III mixture, we suggest the involvement of syndecan-4 and heparan sulfate in p44/p42 mitogen-activated protein kinase and Jun N-terminal/stress-activated protein kinase activation by action of CXCL12 on HeLa cells.	Heparitin Sulfate	176-191	syndecan 4	Homo sapiens	21-31
15819887-9	2005	Finally, by reducing syndecan-4 expression using RNA interference or by pretreating the cells with heparitinase I and III mixture, we suggest the involvement of syndecan-4 and heparan sulfate in p44/p42 mitogen-activated protein kinase and Jun N-terminal/stress-activated protein kinase activation by action of CXCL12 on HeLa cells.	Heparitin Sulfate	176-191	interferon induced protein 44	Homo sapiens	195-198
15819887-9	2005	Finally, by reducing syndecan-4 expression using RNA interference or by pretreating the cells with heparitinase I and III mixture, we suggest the involvement of syndecan-4 and heparan sulfate in p44/p42 mitogen-activated protein kinase and Jun N-terminal/stress-activated protein kinase activation by action of CXCL12 on HeLa cells.	Heparitin Sulfate	176-191	erythrocyte membrane protein band 4.2	Homo sapiens	199-202
15868907-7	2005	Studies performed with synthetic peptides derived from the TSP-1 sequence indicated that two heparin-binding peptides, Hep-I and GGWSHW, located within the NH2-terminal and type 1 repeats respectively, were strong inducers of apoptosis of HL-60 and NB4 cells, suggesting that cell surface heparan sulfate molecules might be involved in the apoptotic effect of TSP-1 on promyelocytic cells.	Heparitin Sulfate	289-304	thrombospondin 1	Homo sapiens	59-64
15647251-1	2005	Heparanase is an endo-beta-glucuronidase that cleaves heparan sulfate (HS) chains of heparan sulfate proteoglycans on cell surfaces and in the extracellular matrix (ECM).	Heparitin Sulfate	54-69	glucuronidase beta	Homo sapiens	22-40
15647251-1	2005	Heparanase is an endo-beta-glucuronidase that cleaves heparan sulfate (HS) chains of heparan sulfate proteoglycans on cell surfaces and in the extracellular matrix (ECM).	Heparitin Sulfate	71-73	glucuronidase beta	Homo sapiens	22-40
15644496-3	2005	Soluble glycosaminoglycans such as heparin and heparan sulfate bind gp120 via V3 and, possibly, a CD4-induced domain.	Heparitin Sulfate	47-62	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	68-80
15644496-3	2005	Soluble glycosaminoglycans such as heparin and heparan sulfate bind gp120 via V3 and, possibly, a CD4-induced domain.	Heparitin Sulfate	47-62	CD4 molecule	Homo sapiens	98-101
15644496-7	2005	In vitro, and in conditions in which gp120 could bind CD4, heparin and heparan sulfate reduced PDI-mediated gp120 reduction by approximately 80%.	Heparitin Sulfate	71-86	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	37-42
15644496-7	2005	In vitro, and in conditions in which gp120 could bind CD4, heparin and heparan sulfate reduced PDI-mediated gp120 reduction by approximately 80%.	Heparitin Sulfate	71-86	CD4 molecule	Homo sapiens	54-57
15644496-7	2005	In vitro, and in conditions in which gp120 could bind CD4, heparin and heparan sulfate reduced PDI-mediated gp120 reduction by approximately 80%.	Heparitin Sulfate	71-86	protein disulfide isomerase family A member 2	Homo sapiens	95-98
15644496-7	2005	In vitro, and in conditions in which gp120 could bind CD4, heparin and heparan sulfate reduced PDI-mediated gp120 reduction by approximately 80%.	Heparitin Sulfate	71-86	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	108-113
15657052-6	2005	Although the testican-2 expressed in EBNA-293 cells carried both heparan sulfate and chondroitin/dermatan sulfate glycosaminoglycan chains, the tissue form always contained only heparan sulfate.	Heparitin Sulfate	65-80	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2	Homo sapiens	13-23
15748207-2	2005	HRG ligands include Zn(2+) and haem, tropomyosin, heparin and heparan sulphate, plasminogen, plasmin, fibrinogen, thrombospondin, IgG, FcgammaR and complement.	Heparitin Sulfate	62-78	histidine rich glycoprotein	Homo sapiens	0-3
15844817-1	2005	The heparan sulfate proteoglycans, syndecan-1 and glypican-1 (glypican), are low affinity receptors for fibroblast growth factor 2 (FGF2).	Heparitin Sulfate	4-19	syndecan 1	Gallus gallus	35-45
15844817-1	2005	The heparan sulfate proteoglycans, syndecan-1 and glypican-1 (glypican), are low affinity receptors for fibroblast growth factor 2 (FGF2).	Heparitin Sulfate	4-19	glypican 1	Gallus gallus	50-60
15844817-1	2005	The heparan sulfate proteoglycans, syndecan-1 and glypican-1 (glypican), are low affinity receptors for fibroblast growth factor 2 (FGF2).	Heparitin Sulfate	4-19	glypican 1	Gallus gallus	50-58
15844817-1	2005	The heparan sulfate proteoglycans, syndecan-1 and glypican-1 (glypican), are low affinity receptors for fibroblast growth factor 2 (FGF2).	Heparitin Sulfate	4-19	fibroblast growth factor 2	Gallus gallus	104-130
15844817-1	2005	The heparan sulfate proteoglycans, syndecan-1 and glypican-1 (glypican), are low affinity receptors for fibroblast growth factor 2 (FGF2).	Heparitin Sulfate	4-19	fibroblast growth factor 2	Gallus gallus	132-136
15528317-7	2005	GzmB binding was correlated with the surface density of heparan sulfate chains, was eliminated on treatment of target cells with heparinase III or sodium chlorate, and was completely blocked by an excess of catalytically inactive GzmB or GzmK.	Heparitin Sulfate	56-71	granzyme B	Homo sapiens	0-4
15528317-8	2005	Although heparan sulfate-bound GzmB was taken up rapidly into intracellular lysosomal compartments, neither of the treatments had an inhibitory influence on apoptosis induced by externally added streptolysin O and GzmB or by natural killer cells.	Heparitin Sulfate	9-24	granzyme B	Homo sapiens	31-35
15799825-4	2005	Heparanase (HPSE-1) is an ECM degradative enzyme, which degrades the heparan sulfate (HS) chains of HSPG at specific intrachain sites.	Heparitin Sulfate	69-84	heparanase	Homo sapiens	12-18
15737842-2	2005	This study tested whether heparanase-1 (HPR1), an endoglycosidase that specifically degrades the heparan sulfate (HS) proteoglycans in the breast extracellular matrix, was associated with the most aggressive DCIS subtypes.	Heparitin Sulfate	97-112	heparanase	Homo sapiens	40-44
15737842-2	2005	This study tested whether heparanase-1 (HPR1), an endoglycosidase that specifically degrades the heparan sulfate (HS) proteoglycans in the breast extracellular matrix, was associated with the most aggressive DCIS subtypes.	Heparitin Sulfate	114-116	heparanase	Homo sapiens	40-44
15737842-7	2005	Among 27 DCIS stained for HS, we found that 8 (67%) of 12 HPR1-negative DCIS had intact HS deposition in the extracellular basement membrane; none of the 15 HPR1-positive DCIS stained HS positive.	Heparitin Sulfate	26-28	heparanase	Homo sapiens	58-62
15737842-7	2005	Among 27 DCIS stained for HS, we found that 8 (67%) of 12 HPR1-negative DCIS had intact HS deposition in the extracellular basement membrane; none of the 15 HPR1-positive DCIS stained HS positive.	Heparitin Sulfate	88-90	heparanase	Homo sapiens	58-62
15737842-7	2005	Among 27 DCIS stained for HS, we found that 8 (67%) of 12 HPR1-negative DCIS had intact HS deposition in the extracellular basement membrane; none of the 15 HPR1-positive DCIS stained HS positive.	Heparitin Sulfate	88-90	heparanase	Homo sapiens	58-62
15799825-4	2005	Heparanase (HPSE-1) is an ECM degradative enzyme, which degrades the heparan sulfate (HS) chains of HSPG at specific intrachain sites.	Heparitin Sulfate	69-84	syndecan 2	Homo sapiens	100-104
15799825-4	2005	Heparanase (HPSE-1) is an ECM degradative enzyme, which degrades the heparan sulfate (HS) chains of HSPG at specific intrachain sites.	Heparitin Sulfate	86-88	heparanase	Homo sapiens	12-18
15799825-4	2005	Heparanase (HPSE-1) is an ECM degradative enzyme, which degrades the heparan sulfate (HS) chains of HSPG at specific intrachain sites.	Heparitin Sulfate	86-88	syndecan 2	Homo sapiens	100-104
15759080-3	2005	Recognition of tumor cells by the NCRs NKp30 and NKp46 involves heparan sulfate epitopes expressed on the tumor cell membrane.	Heparitin Sulfate	64-79	natural cytotoxicity triggering receptor 3	Homo sapiens	39-44
15759080-3	2005	Recognition of tumor cells by the NCRs NKp30 and NKp46 involves heparan sulfate epitopes expressed on the tumor cell membrane.	Heparitin Sulfate	64-79	natural cytotoxicity triggering receptor 1	Homo sapiens	49-54
15471949-2	2005	Heparanase-1 (heparanase), an enzyme that cleaves heparan sulfate chains, is expressed at high levels in some patients with myeloma and promotes metastasis of some tumor types (eg, breast, lymphoma).	Heparitin Sulfate	50-65	heparanase	Homo sapiens	0-25
15709168-1	2005	PURPOSE: Heparanase degrades heparan sulfate and has been implicated in tumor invasion and metastasis.	Heparitin Sulfate	29-44	heparanase	Homo sapiens	9-19
15614762-0	2005	Non-heparan sulfate-binding interactions of endostatin/collagen XVIII in murine development.	Heparitin Sulfate	4-19	collagen, type XVIII, alpha 1	Mus musculus	44-54
15614762-7	2005	Strikingly increased staining specificity was observed with a non-heparin/heparan sulfate-binding endostatin probe.	Heparitin Sulfate	74-89	collagen, type XVIII, alpha 1	Mus musculus	98-108
15614762-8	2005	In contrast, elimination of the heparan sulfate binding site from VEGF led to complete loss of binding.	Heparitin Sulfate	32-47	vascular endothelial growth factor A	Mus musculus	66-70
15748998-0	2005	Heparan sulphate interacts with tropoelastin, with some tropoelastin peptides and is present in human dermis elastic fibers.	Heparitin Sulfate	0-16	elastin	Homo sapiens	32-44
15691886-1	2005	Insulin-like growth factor binding proteins (IGFBPs) -3 and -5 are known to interact with various components of the extracellular matrix (ECM; e.g. heparin and heparan sulphate) and this interaction is believed to affect the affinity of both IGFBP species for their cognate ligands--IGF-I and -II.	Heparitin Sulfate	160-176	insulin-like growth factor binding protein 3	Mus musculus	45-51
15691886-1	2005	Insulin-like growth factor binding proteins (IGFBPs) -3 and -5 are known to interact with various components of the extracellular matrix (ECM; e.g. heparin and heparan sulphate) and this interaction is believed to affect the affinity of both IGFBP species for their cognate ligands--IGF-I and -II.	Heparitin Sulfate	160-176	insulin-like growth factor 1	Mus musculus	283-296
15748998-5	2005	In in vitro experiments, HS induced substantial changes in the coacervation temperature and in the aggregation properties of recombinant tropoelastin and of synthetic peptides (EDPs) corresponding to sequences encoded by exons 18, 20, 24 and 30 of the human tropoelastin gene.	Heparitin Sulfate	25-27	elastin	Homo sapiens	258-270
15748998-0	2005	Heparan sulphate interacts with tropoelastin, with some tropoelastin peptides and is present in human dermis elastic fibers.	Heparitin Sulfate	0-16	elastin	Homo sapiens	56-68
15748998-3	2005	By immunocytochemistry, HS chains were identified as associated with the amorphous elastin component in the human dermis and remained associated with the residual elastin in the partially degenerated fibers of old subjects.	Heparitin Sulfate	24-26	elastin	Homo sapiens	83-90
15748998-3	2005	By immunocytochemistry, HS chains were identified as associated with the amorphous elastin component in the human dermis and remained associated with the residual elastin in the partially degenerated fibers of old subjects.	Heparitin Sulfate	24-26	elastin	Homo sapiens	163-170
15748998-5	2005	In in vitro experiments, HS induced substantial changes in the coacervation temperature and in the aggregation properties of recombinant tropoelastin and of synthetic peptides (EDPs) corresponding to sequences encoded by exons 18, 20, 24 and 30 of the human tropoelastin gene.	Heparitin Sulfate	25-27	elastin	Homo sapiens	137-149
15537637-9	2005	Most interestingly, the heparan sulfate chains of GPC3 were not required for its stimulatory activity on Wnt5a signaling and for the formation of GPC3-Wnt5a complexes.	Heparitin Sulfate	24-39	glypican 3	Mus musculus	50-54
15671174-1	2005	The importance of heparan sulfate proteoglycans has been highlighted by a number of human genetic disorders associated with mutations in genes encoding for heparan sulfate proteoglycan protein cores or biosynthetic enzymes required for heparan sulfate (HS) assembly.	Heparitin Sulfate	253-255	CD44 molecule (Indian blood group)	Homo sapiens	18-46
15362977-1	2005	The C-terminal region of EC-SOD (extracellular superoxide dismutase) mediates the binding to both heparin/heparan sulphate and type I collagen.	Heparitin Sulfate	106-122	superoxide dismutase 3	Homo sapiens	25-31
15652173-7	2005	The antithrombin-mediated anti-factor Xa activity of human liver heparan sulfate, however, was much lower than porcine intestinal (pharmaceutical) heparin but was comparable to standard porcine intestinal heparan sulfate.	Heparitin Sulfate	65-80	serpin family C member 1	Homo sapiens	4-16
15652173-8	2005	Moreover, human liver heparan sulfate shows higher degree of sulfation than heparan sulfate isolated from porcine liver or from the human hepatoma Hep 2G cell line.	Heparitin Sulfate	22-37	DNL-type zinc finger	Homo sapiens	147-150
15362977-1	2005	The C-terminal region of EC-SOD (extracellular superoxide dismutase) mediates the binding to both heparin/heparan sulphate and type I collagen.	Heparitin Sulfate	106-122	superoxide dismutase 3	Homo sapiens	33-67
15635159-7	2005	On the other hand, SDS-polyacrylamide gel electrophoresis and Western blot analysis of the PG core proteins indicated that the Na-SP-releasable PGs are both a large heparan sulfate PG, perlecan, and a small chondroitin/dermatan sulfate PG, biglycan, without change in the size of the core proteins.	Heparitin Sulfate	165-180	nuclear autoantigenic sperm protein	Bos taurus	127-132
15537641-8	2005	Glycosaminoglycanases with assorted glycosaminoglycan (GAG) cleavage specificities coupled with Western analyses of the cleaved GAG "stubs" demonstrated that the DSP GAG attachments contain chondroitin 6-sulfate, but not keratan sulfate, heparan sulfate, chondroitin, or chondroitin 4-sulfate.	Heparitin Sulfate	238-253	dentin sialophosphoprotein	Sus scrofa	162-165
15331374-7	2005	Among the FGF-2 molecules found within the interstitium, 2% are free and 98% are bound to interstitial heparan sulfate proteoglycans.	Heparitin Sulfate	103-118	fibroblast growth factor 2	Canis lupus familiaris	10-15
15628854-7	2005	Several observations suggest that these aggregates consist of Fg-CPP(TAT(PTD)) bound to membrane-associated heparan sulfate (HS).	Heparitin Sulfate	108-123	tyrosine aminotransferase	Homo sapiens	69-72
15628854-10	2005	Enzymatic removal of extracellular HS reduced the rate of both Fg-CPP(TAT(PTD)) uptake and aggregate formation, demonstrating that HS is involved in the uptake mechanism.	Heparitin Sulfate	35-37	tyrosine aminotransferase	Homo sapiens	70-73
15628854-10	2005	Enzymatic removal of extracellular HS reduced the rate of both Fg-CPP(TAT(PTD)) uptake and aggregate formation, demonstrating that HS is involved in the uptake mechanism.	Heparitin Sulfate	131-133	tyrosine aminotransferase	Homo sapiens	70-73
15694132-0	2005	Endostatin"s heparan sulfate-binding site is essential for inhibition of angiogenesis and enhances in situ binding to capillary-like structures in bone explants.	Heparitin Sulfate	13-28	collagen type XVIII alpha 1 chain	Homo sapiens	0-10
15694132-1	2005	The functional role of endostatin"s affinity for heparan sulfates was addressed using an ex vivo bone angiogenesis model.	Heparitin Sulfate	49-65	collagen type XVIII alpha 1 chain	Homo sapiens	23-33
15694132-4	2005	Mutant non-heparan sulfate binding endostatin and the collagen XV endostatin homologue were ineffective.	Heparitin Sulfate	11-26	collagen type XVIII alpha 1 chain	Homo sapiens	35-45
15694132-7	2005	Our data indicate that endostatin"s angiostatic function is heparan sulfate-dependent, and that in situ-binding of endostatin to endothelial cells is increased by heparan sulfates.	Heparitin Sulfate	60-75	collagen type XVIII alpha 1 chain	Homo sapiens	23-33
15694132-7	2005	Our data indicate that endostatin"s angiostatic function is heparan sulfate-dependent, and that in situ-binding of endostatin to endothelial cells is increased by heparan sulfates.	Heparitin Sulfate	163-179	collagen type XVIII alpha 1 chain	Homo sapiens	115-125
15639191-1	2005	Mucopolysaccharidosis I is a lysosomal storage disorder caused by a deficiency of the lysosomal hydrolase alpha-l-iduronidase, which is required for the degradation of heparan sulphate and dermatan sulphate.	Heparitin Sulfate	168-184	alpha-L-iduronidase	Homo sapiens	106-125
15324302-0	2004	Cross-talk of anosmin-1, the protein implicated in X-linked Kallmann"s syndrome, with heparan sulphate and urokinase-type plasminogen activator.	Heparitin Sulfate	86-102	anosmin 1	Homo sapiens	14-23
15603738-3	2004	Molecular cloning reveals that dak and box encode ext2 and extl3, glycosyltransferases implicated in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	101-116	exostosin glycosyltransferase 2	Danio rerio	31-34
15603738-3	2004	Molecular cloning reveals that dak and box encode ext2 and extl3, glycosyltransferases implicated in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	101-116	exostosin glycosyltransferase 2	Danio rerio	50-54
15603738-3	2004	Molecular cloning reveals that dak and box encode ext2 and extl3, glycosyltransferases implicated in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	101-116	exostosin-like glycosyltransferase 3	Danio rerio	59-64
15603738-3	2004	Molecular cloning reveals that dak and box encode ext2 and extl3, glycosyltransferases implicated in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	118-120	exostosin glycosyltransferase 2	Danio rerio	31-34
15603738-3	2004	Molecular cloning reveals that dak and box encode ext2 and extl3, glycosyltransferases implicated in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	118-120	exostosin glycosyltransferase 2	Danio rerio	50-54
15603738-3	2004	Molecular cloning reveals that dak and box encode ext2 and extl3, glycosyltransferases implicated in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	118-120	exostosin-like glycosyltransferase 3	Danio rerio	59-64
15603738-6	2004	dak;box double mutants show synthetic pathfinding phenotypes that phenocopy robo2 mutants, suggesting that Robo2 function requires HS in vivo; however, tract sorting does not require Robo function, since it is normal in robo2 null mutants.	Heparitin Sulfate	131-133	exostosin glycosyltransferase 2	Danio rerio	0-3
15603738-6	2004	dak;box double mutants show synthetic pathfinding phenotypes that phenocopy robo2 mutants, suggesting that Robo2 function requires HS in vivo; however, tract sorting does not require Robo function, since it is normal in robo2 null mutants.	Heparitin Sulfate	131-133	roundabout, axon guidance receptor, homolog 2 (Drosophila)	Danio rerio	107-112
15603738-6	2004	dak;box double mutants show synthetic pathfinding phenotypes that phenocopy robo2 mutants, suggesting that Robo2 function requires HS in vivo; however, tract sorting does not require Robo function, since it is normal in robo2 null mutants.	Heparitin Sulfate	131-133	roundabout, axon guidance receptor, homolog 2 (Drosophila)	Danio rerio	107-111
15557552-6	2004	All mutations reduced or abrogated viral entry through HVEM and 3-O-sulfated heparan sulfate, indicating that similar features of gD are critical for functional interactions with both these receptors.	Heparitin Sulfate	77-92	TNF receptor superfamily member 14	Homo sapiens	55-65
15557552-6	2004	All mutations reduced or abrogated viral entry through HVEM and 3-O-sulfated heparan sulfate, indicating that similar features of gD are critical for functional interactions with both these receptors.	Heparitin Sulfate	77-92	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	130-132
15557552-8	2004	These and other results show that features of gD, including conformation of the N terminus, critical for functional interactions with HVEM/3-O-sulfated heparan sulfate, differ from those critical for interactions with nectin-1.	Heparitin Sulfate	152-167	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	46-48
16082081-7	2005	CONCLUSIONS: dFGF represents a potential treatment to enhance functional recovery after stroke and offers several advantages over bFGF, including stability and independence from extracellular heparan sulfates.	Heparitin Sulfate	192-208	branchless	Drosophila melanogaster	13-17
15738663-3	2005	Heparan sulfate chains bind and potentiate the activities of various growth factors such as fibroblast growth factor 2 (FGF-2).	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	92-118
15738663-3	2005	Heparan sulfate chains bind and potentiate the activities of various growth factors such as fibroblast growth factor 2 (FGF-2).	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	120-125
15738663-10	2005	Heparitinase digestion demonstrated that recombinant PlnDI was substituted with heparan sulfate and that these heparan sulfate chains were critically important not only for efficient integration of PlnDI into scaffolds, but also for FGF-2 binding and retention.	Heparitin Sulfate	111-126	fibroblast growth factor 2	Homo sapiens	233-238
15572165-4	2004	Recent evidence support this notion: first, the presence of two heparin-binding domains in ColQ that interact with heparan sulfate proteoglycans (HSPGs) at the synaptic basal lamina; and second, a knockout mouse for perlecan, a HSPG concentrated in nerve-muscle contact, in which absence of asymmetric AChE at the NMJ is observed.	Heparitin Sulfate	115-130	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	Mus musculus	91-95
15324302-3	2004	Anosmin-1 contains a WAP (whey acidic protein-like) domain and four contiguous FnIII (fibronectin-like type III) repeats; its WAP domain shows similarity to known serine protease inhibitors, whereas the FnIII domains contain HS (heparan sulphate)-binding sequences.	Heparitin Sulfate	225-227	anosmin 1	Homo sapiens	0-9
15324302-3	2004	Anosmin-1 contains a WAP (whey acidic protein-like) domain and four contiguous FnIII (fibronectin-like type III) repeats; its WAP domain shows similarity to known serine protease inhibitors, whereas the FnIII domains contain HS (heparan sulphate)-binding sequences.	Heparitin Sulfate	229-245	anosmin 1	Homo sapiens	0-9
15324302-11	2004	We thus propose that anosmin-1 may modulate the catalytic activity of uPA and its signalling pathway, whereas HS determines cell surface localization of the anosmin-1-uPA complex.	Heparitin Sulfate	110-112	anosmin 1	Homo sapiens	157-166
15324302-11	2004	We thus propose that anosmin-1 may modulate the catalytic activity of uPA and its signalling pathway, whereas HS determines cell surface localization of the anosmin-1-uPA complex.	Heparitin Sulfate	110-112	plasminogen activator, urokinase	Homo sapiens	167-170
15557149-4	2004	To mediate "haptorepulsion" of pDCs, CXCR3 requires the encounter of its cognate ligands immobilized, optimally by heparan sulfate, in a form of a negative gradient.	Heparitin Sulfate	115-130	C-X-C motif chemokine receptor 3	Homo sapiens	37-42
15253930-1	2004	Heparan sulfate/heparin N-deacetylase/N-sulfotransferase-1 (NDST-1) is a critical enzyme involved in heparan sulfate/heparin biosynthesis.	Heparitin Sulfate	0-15	N-deacetylase and N-sulfotransferase 1	Rattus norvegicus	60-66
15253930-1	2004	Heparan sulfate/heparin N-deacetylase/N-sulfotransferase-1 (NDST-1) is a critical enzyme involved in heparan sulfate/heparin biosynthesis.	Heparitin Sulfate	101-116	N-deacetylase and N-sulfotransferase 1	Rattus norvegicus	60-66
15347686-7	2004	The ratio of chondroitin sulfate to heparan sulfate likewise increased on syndecan-1 from gel culture.	Heparitin Sulfate	36-51	syndecan 1	Mus musculus	74-84
15528465-2	2004	Although heparan sulfate proteoglycan is an important ligand for ecSOD, little is known about other biological binding partners of ecSOD.	Heparitin Sulfate	9-24	superoxide dismutase 3, extracellular	Mus musculus	65-70
15385438-0	2004	Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells.	Heparitin Sulfate	82-97	TSC complex subunit 1	Homo sapiens	32-48
15548653-0	2004	Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism.	Heparitin Sulfate	138-153	anosmin 1	Homo sapiens	0-9
15548653-0	2004	Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism.	Heparitin Sulfate	138-153	fibroblast growth factor receptor 1	Homo sapiens	20-55
15548653-2	2004	Here, we report a functional interaction between anosmin-1 and the FGFR1-FGF2-heparan sulfate complex, leading to amplified responses in the FGFR1 signaling pathway.	Heparitin Sulfate	78-93	anosmin 1	Homo sapiens	49-58
15548653-2	2004	Here, we report a functional interaction between anosmin-1 and the FGFR1-FGF2-heparan sulfate complex, leading to amplified responses in the FGFR1 signaling pathway.	Heparitin Sulfate	78-93	fibroblast growth factor receptor 1	Homo sapiens	67-72
15548653-2	2004	Here, we report a functional interaction between anosmin-1 and the FGFR1-FGF2-heparan sulfate complex, leading to amplified responses in the FGFR1 signaling pathway.	Heparitin Sulfate	78-93	fibroblast growth factor 2	Homo sapiens	73-77
15548653-2	2004	Here, we report a functional interaction between anosmin-1 and the FGFR1-FGF2-heparan sulfate complex, leading to amplified responses in the FGFR1 signaling pathway.	Heparitin Sulfate	78-93	fibroblast growth factor receptor 1	Homo sapiens	141-146
15548653-4	2004	Furthermore, anosmin-1 enhances FGF2 signaling specifically through FGFR1 IIIc in heterologous BaF3 lymphoid cells in a heparan sulfate-dependent manner.	Heparitin Sulfate	120-135	anosmin 1	Homo sapiens	13-22
15548653-4	2004	Furthermore, anosmin-1 enhances FGF2 signaling specifically through FGFR1 IIIc in heterologous BaF3 lymphoid cells in a heparan sulfate-dependent manner.	Heparitin Sulfate	120-135	fibroblast growth factor 2	Mus musculus	32-36
15548653-4	2004	Furthermore, anosmin-1 enhances FGF2 signaling specifically through FGFR1 IIIc in heterologous BaF3 lymphoid cells in a heparan sulfate-dependent manner.	Heparitin Sulfate	120-135	fibroblast growth factor receptor 1	Mus musculus	68-73
15544705-1	2004	BACKGROUND: Lipoprotein lipase (LPL) is anchored at the vascular endothelium through interaction with heparan sulfate.	Heparitin Sulfate	102-117	lipoprotein lipase	Rattus norvegicus	12-30
15544705-1	2004	BACKGROUND: Lipoprotein lipase (LPL) is anchored at the vascular endothelium through interaction with heparan sulfate.	Heparitin Sulfate	102-117	lipoprotein lipase	Rattus norvegicus	32-35
15270718-4	2004	IFNgamma activity is modulated by the binding of its C-terminal domain to HS (heparan sulphate), a glycosaminoglycan found in the extracellular matrix and at the cell surface.	Heparitin Sulfate	74-76	interferon gamma	Homo sapiens	0-8
15270718-4	2004	IFNgamma activity is modulated by the binding of its C-terminal domain to HS (heparan sulphate), a glycosaminoglycan found in the extracellular matrix and at the cell surface.	Heparitin Sulfate	78-94	interferon gamma	Homo sapiens	0-8
15385438-0	2004	Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells.	Heparitin Sulfate	82-97	exostosin glycosyltransferase 1	Homo sapiens	54-65
15385438-0	2004	Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells.	Heparitin Sulfate	82-97	exostosin glycosyltransferase 1	Homo sapiens	67-71
15385438-4	2004	We also show that, at the biochemical and cellular levels, the epigenetic inactivation of EXT1, a glycosyltransferase, leads to the loss of heparan sulfate (HS) synthesis.	Heparitin Sulfate	140-155	exostosin glycosyltransferase 1	Homo sapiens	90-94
15385438-4	2004	We also show that, at the biochemical and cellular levels, the epigenetic inactivation of EXT1, a glycosyltransferase, leads to the loss of heparan sulfate (HS) synthesis.	Heparitin Sulfate	157-159	exostosin glycosyltransferase 1	Homo sapiens	90-94
15345688-5	2004	Furthermore, a synthetic peptide (27-mer) corresponding to a HS binding site of SAA, blocks amyloid deposition at a concentration that is several-orders-of-magnitude lower than any other peptide-based inhibitor previously reported.	Heparitin Sulfate	61-63	serum amyloid A cluster	Mus musculus	80-83
15331606-1	2004	Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that has a high affinity for heparin and heparan sulfate.	Heparitin Sulfate	137-152	heparin binding EGF like growth factor	Homo sapiens	0-38
15331606-1	2004	Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that has a high affinity for heparin and heparan sulfate.	Heparitin Sulfate	137-152	heparin binding EGF like growth factor	Homo sapiens	40-46
15331606-1	2004	Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that has a high affinity for heparin and heparan sulfate.	Heparitin Sulfate	137-152	epidermal growth factor	Homo sapiens	16-19
15518882-2	2004	A recently identified member of this protein family is melanoma differentiation associated gene-9 (mda-9), also known as syntenin, which was first identified as a gene down-regulated during human melanoma differentiation as mda-9 and subsequently recognized as an interacting partner of the cell-surface heparan sulfate syndecans, syntenin.	Heparitin Sulfate	304-319	syndecan binding protein	Homo sapiens	99-104
15449170-1	2004	Perlecan is one of major heparan sulfate proteoglycans in the glomerular basement membrane and is reduced in the renal parenchyma of diabetic patients and animals with proteinuria.	Heparitin Sulfate	25-40	heparan sulfate proteoglycan 2	Rattus norvegicus	0-8
15518882-2	2004	A recently identified member of this protein family is melanoma differentiation associated gene-9 (mda-9), also known as syntenin, which was first identified as a gene down-regulated during human melanoma differentiation as mda-9 and subsequently recognized as an interacting partner of the cell-surface heparan sulfate syndecans, syntenin.	Heparitin Sulfate	304-319	syndecan binding protein	Homo sapiens	121-129
15518882-2	2004	A recently identified member of this protein family is melanoma differentiation associated gene-9 (mda-9), also known as syntenin, which was first identified as a gene down-regulated during human melanoma differentiation as mda-9 and subsequently recognized as an interacting partner of the cell-surface heparan sulfate syndecans, syntenin.	Heparitin Sulfate	304-319	syndecan binding protein	Homo sapiens	224-229
15518882-2	2004	A recently identified member of this protein family is melanoma differentiation associated gene-9 (mda-9), also known as syntenin, which was first identified as a gene down-regulated during human melanoma differentiation as mda-9 and subsequently recognized as an interacting partner of the cell-surface heparan sulfate syndecans, syntenin.	Heparitin Sulfate	304-319	syndecan binding protein	Homo sapiens	331-339
15496673-5	2004	Enzymatic removal of heparan sulfates from cultured neurons and a mutation in the heparin-binding domain of NCAM diminished synaptogenic activity of neuronally expressed PSA-NCAM, suggesting that interaction of NCAM with heparan sulfate proteoglycans mediates this activity.	Heparitin Sulfate	21-37	neural cell adhesion molecule 1	Homo sapiens	174-178
15496673-5	2004	Enzymatic removal of heparan sulfates from cultured neurons and a mutation in the heparin-binding domain of NCAM diminished synaptogenic activity of neuronally expressed PSA-NCAM, suggesting that interaction of NCAM with heparan sulfate proteoglycans mediates this activity.	Heparitin Sulfate	21-37	neural cell adhesion molecule 1	Homo sapiens	174-178
15496673-7	2004	Enzymatic removal of PSA and heparan sulfates also blocked the increase in the number of perforated spine synapses associated with NMDA receptor-dependent LTP in the CA1 region of organotypic hippocampal cultures.	Heparitin Sulfate	29-45	carbonic anhydrase 1	Homo sapiens	166-169
15292258-0	2004	Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV.	Heparitin Sulfate	0-15	C-X-C motif chemokine ligand 12	Homo sapiens	49-78
15292258-1	2004	Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that is constitutively expressed in most tissues and displayed on the cell surface in association with heparan sulfate (HS).	Heparitin Sulfate	160-175	C-X-C motif chemokine ligand 12	Homo sapiens	0-29
15292258-1	2004	Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that is constitutively expressed in most tissues and displayed on the cell surface in association with heparan sulfate (HS).	Heparitin Sulfate	160-175	C-X-C motif chemokine ligand 12	Homo sapiens	31-36
15292258-1	2004	Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that is constitutively expressed in most tissues and displayed on the cell surface in association with heparan sulfate (HS).	Heparitin Sulfate	177-179	C-X-C motif chemokine ligand 12	Homo sapiens	0-29
15292258-1	2004	Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that is constitutively expressed in most tissues and displayed on the cell surface in association with heparan sulfate (HS).	Heparitin Sulfate	177-179	C-X-C motif chemokine ligand 12	Homo sapiens	31-36
15292258-5	2004	We report here that heparin and HS specifically prevent the processing of SDF-1 by DPP IV expressed by Caco-2 cells.	Heparitin Sulfate	32-34	C-X-C motif chemokine ligand 12	Homo sapiens	74-79
15292258-5	2004	We report here that heparin and HS specifically prevent the processing of SDF-1 by DPP IV expressed by Caco-2 cells.	Heparitin Sulfate	32-34	dipeptidyl peptidase 4	Homo sapiens	83-89
15292258-9	2004	Finally a structural model of SDF-1, in complex with HS oligosaccharides of defined length, rationalizes the experimental data.	Heparitin Sulfate	53-55	C-X-C motif chemokine ligand 12	Homo sapiens	30-35
15292258-0	2004	Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV.	Heparitin Sulfate	0-15	C-X-C motif chemokine ligand 12	Homo sapiens	80-85
15292258-0	2004	Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV.	Heparitin Sulfate	0-15	C-X-C motif chemokine ligand 12	Homo sapiens	87-93
15292258-0	2004	Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV.	Heparitin Sulfate	0-15	dipeptidyl peptidase 4	Homo sapiens	125-153
15319440-0	2004	Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.	Heparitin Sulfate	0-15	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	71-76
15319440-0	2004	Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.	Heparitin Sulfate	0-15	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	81-86
15319440-4	2004	Here we report that heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 completely lacks N-sulfation but still contains 6-O-sulfate groups, demonstrating that 6-O-sulfation can occur without prior N-sulfation.	Heparitin Sulfate	20-35	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	91-96
15319440-4	2004	Here we report that heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 completely lacks N-sulfation but still contains 6-O-sulfate groups, demonstrating that 6-O-sulfation can occur without prior N-sulfation.	Heparitin Sulfate	20-35	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	101-106
15203110-5	2004	Heparin, heparan sulfate and dermatan sulfate, at various HARP to glycosaminoglycan ratios, partially protect HARP from plasmin degradation.	Heparitin Sulfate	9-24	pleiotrophin	Homo sapiens	58-62
15203110-5	2004	Heparin, heparan sulfate and dermatan sulfate, at various HARP to glycosaminoglycan ratios, partially protect HARP from plasmin degradation.	Heparitin Sulfate	9-24	pleiotrophin	Homo sapiens	110-114
15203110-5	2004	Heparin, heparan sulfate and dermatan sulfate, at various HARP to glycosaminoglycan ratios, partially protect HARP from plasmin degradation.	Heparitin Sulfate	9-24	plasminogen	Homo sapiens	120-127
15368349-1	2004	Heparanase (HPSE-1) is an endo-beta-D-glucuronidase involved in the degradation of cell-surface/extracellular matrix heparan sulfate (HS) in normal and neoplastic tissues.	Heparitin Sulfate	117-132	heparanase	Homo sapiens	12-18
15368349-1	2004	Heparanase (HPSE-1) is an endo-beta-D-glucuronidase involved in the degradation of cell-surface/extracellular matrix heparan sulfate (HS) in normal and neoplastic tissues.	Heparitin Sulfate	117-132	glucuronidase beta	Homo sapiens	31-51
15368349-1	2004	Heparanase (HPSE-1) is an endo-beta-D-glucuronidase involved in the degradation of cell-surface/extracellular matrix heparan sulfate (HS) in normal and neoplastic tissues.	Heparitin Sulfate	134-136	heparanase	Homo sapiens	12-18
15368349-1	2004	Heparanase (HPSE-1) is an endo-beta-D-glucuronidase involved in the degradation of cell-surface/extracellular matrix heparan sulfate (HS) in normal and neoplastic tissues.	Heparitin Sulfate	134-136	glucuronidase beta	Homo sapiens	31-51
15325306-0	2004	Radiolabeled heparan sulfate immobilized on microplate as substrate for the detection of heparanase activity.	Heparitin Sulfate	13-28	heparanase	Homo sapiens	89-99
15533755-3	2004	Moreover, the interplay between heparan sulfate and the extracellular enzyme heparanase-1 also has important regulatory implications.	Heparitin Sulfate	32-47	heparanase	Homo sapiens	77-89
15325306-1	2004	We developed a quantitative assay to monitor the enzymatic activity of heparanase, a protein responsible for the degradation of heparan sulfate (HS) present on cell surface and extracellular matrix.	Heparitin Sulfate	128-143	heparanase	Homo sapiens	71-81
15325306-1	2004	We developed a quantitative assay to monitor the enzymatic activity of heparanase, a protein responsible for the degradation of heparan sulfate (HS) present on cell surface and extracellular matrix.	Heparitin Sulfate	145-147	heparanase	Homo sapiens	71-81
15226297-0	2004	Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors.	Heparitin Sulfate	168-183	syndecan 1	Mus musculus	30-40
15226297-0	2004	Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors.	Heparitin Sulfate	168-183	syndecan 4	Mus musculus	45-55
15226297-5	2004	Functional analysis using a BIAcore system showed that basic fibroblast growth factor (bFGF) specifically bound only to the HS chains of both syndecans, whereas midkine (MK) and pleiotrophin (PTN) bound not only to the HS but also to the CS chains.	Heparitin Sulfate	124-126	fibroblast growth factor 2	Mus musculus	55-85
15226297-5	2004	Functional analysis using a BIAcore system showed that basic fibroblast growth factor (bFGF) specifically bound only to the HS chains of both syndecans, whereas midkine (MK) and pleiotrophin (PTN) bound not only to the HS but also to the CS chains.	Heparitin Sulfate	124-126	fibroblast growth factor 2	Mus musculus	87-91
15226297-7	2004	Intriguingly, removal of the CS chains decreased the association and dissociation rate constants of MK, PTN, and bFGF for both syndecans, suggesting the simultaneous binding of these growth factors to both types of chains, producing a ternary complex that transfers the growth factors to the corresponding cell surface receptors more efficiently compared with the HS chains alone.	Heparitin Sulfate	364-366	midkine	Mus musculus	100-102
15226297-8	2004	The involvement of the core protein was also shown in the binding of MK and PTN to syndecan-1, suggesting the possibility of cooperation with the HS and/or CS chains in the binding of these growth factors and their delivery to the cell surface receptors.	Heparitin Sulfate	146-148	midkine	Mus musculus	69-71
15226297-8	2004	The involvement of the core protein was also shown in the binding of MK and PTN to syndecan-1, suggesting the possibility of cooperation with the HS and/or CS chains in the binding of these growth factors and their delivery to the cell surface receptors.	Heparitin Sulfate	146-148	pleiotrophin	Mus musculus	76-79
15226297-8	2004	The involvement of the core protein was also shown in the binding of MK and PTN to syndecan-1, suggesting the possibility of cooperation with the HS and/or CS chains in the binding of these growth factors and their delivery to the cell surface receptors.	Heparitin Sulfate	146-148	syndecan 1	Mus musculus	83-93
15109301-9	2004	However, oligosaccharides or heparin were unable to restore adhesion of heparinase-treated T-lymphocytes, indicating that HS has to be present on the cell membrane to support the pro-adhesive activity of CyPB.	Heparitin Sulfate	122-124	peptidylprolyl isomerase B	Homo sapiens	204-208
15305020-1	2004	We recently suggested that the transferrin (Tf)-gallium-67 (67Ga) complex dissociated on the surface of the hepatocytes after partial hepatectomy and free 67Ga bound to heparan sulfate in the extracellular matrix.	Heparitin Sulfate	169-184	transferrin	Rattus norvegicus	31-42
15109301-0	2004	Octasaccharide is the minimal length unit required for efficient binding of cyclophilin B to heparin and cell surface heparan sulphate.	Heparitin Sulfate	118-134	peptidylprolyl isomerase B	Homo sapiens	76-89
15109301-4	2004	Characterization of the HS-binding unit is critical to understand the requirement of HS in pro-adhesive activity of CyPB.	Heparitin Sulfate	24-26	peptidylprolyl isomerase B	Homo sapiens	116-120
15208308-9	2004	Competition studies at 37 degrees C indicated that the 190-kDa hHARE binds HA and chondroitin better than dermatan sulfate and chondroitin sulfates A, C, D, and E, but it does not bind to heparin, heparan sulfate, or keratan sulfate.	Heparitin Sulfate	197-212	stabilin 2	Homo sapiens	63-68
15246007-1	2004	Heparanase, a mammalian endoglycosidase that specifically cleaves heparan sulfate (HS), has been found in many tissues.	Heparitin Sulfate	66-81	heparanase	Homo sapiens	0-10
15246007-1	2004	Heparanase, a mammalian endoglycosidase that specifically cleaves heparan sulfate (HS), has been found in many tissues.	Heparitin Sulfate	83-85	heparanase	Homo sapiens	0-10
15246007-5	2004	In the past, measurement of heparanase enzyme activity was done either by the detection of the degradation of fluorescent or radiolabeled HS chains by gel filtration procedures or by the use of radiolabeled substrate conjugated to solid matrices for the easy separation of degraded HS chains.	Heparitin Sulfate	138-140	heparanase	Homo sapiens	28-38
15246007-5	2004	In the past, measurement of heparanase enzyme activity was done either by the detection of the degradation of fluorescent or radiolabeled HS chains by gel filtration procedures or by the use of radiolabeled substrate conjugated to solid matrices for the easy separation of degraded HS chains.	Heparitin Sulfate	282-284	heparanase	Homo sapiens	28-38
15316057-1	2004	BACKGROUND: Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane.	Heparitin Sulfate	59-74	heparanase	Mus musculus	12-22
15334457-9	2004	Up-regulation of RANKL by FGF-2 on RASFs was diminished by the removal of heparan sulfate with heparitinase.	Heparitin Sulfate	74-89	TNF superfamily member 11	Homo sapiens	17-22
15334457-9	2004	Up-regulation of RANKL by FGF-2 on RASFs was diminished by the removal of heparan sulfate with heparitinase.	Heparitin Sulfate	74-89	fibroblast growth factor 2	Homo sapiens	26-31
15305020-1	2004	We recently suggested that the transferrin (Tf)-gallium-67 (67Ga) complex dissociated on the surface of the hepatocytes after partial hepatectomy and free 67Ga bound to heparan sulfate in the extracellular matrix.	Heparitin Sulfate	169-184	transferrin	Rattus norvegicus	44-46
15259000-5	2004	GPI-PLD binding to heparan sulphate proteoglycan was determined in the absence or presence of heparan sulphate or heparin.	Heparitin Sulfate	19-35	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-7
15259000-5	2004	GPI-PLD binding to heparan sulphate proteoglycan was determined in the absence or presence of heparan sulphate or heparin.	Heparitin Sulfate	94-110	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-7
15259000-9	2004	Heparan sulphate proteoglycan, which is commonly present in most amyloid, bound GPI-PLD in vitro.	Heparitin Sulfate	0-16	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	80-87
15161920-0	2004	Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains.	Heparitin Sulfate	70-85	exostosin glycosyltransferase 1	Mus musculus	51-55
15260846-1	2004	Heparan sulfate (HS), which is degraded by heparanase, plays an important role in cell adhesion, insolubility of the extracellular matrix (ECM) and as a reservoir for various growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF).	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	198-228
15260846-1	2004	Heparan sulfate (HS), which is degraded by heparanase, plays an important role in cell adhesion, insolubility of the extracellular matrix (ECM) and as a reservoir for various growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF).	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	230-234
15260846-1	2004	Heparan sulfate (HS), which is degraded by heparanase, plays an important role in cell adhesion, insolubility of the extracellular matrix (ECM) and as a reservoir for various growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF).	Heparitin Sulfate	0-15	vascular endothelial growth factor A	Homo sapiens	240-274
15260846-1	2004	Heparan sulfate (HS), which is degraded by heparanase, plays an important role in cell adhesion, insolubility of the extracellular matrix (ECM) and as a reservoir for various growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF).	Heparitin Sulfate	0-15	vascular endothelial growth factor A	Homo sapiens	276-280
15260846-1	2004	Heparan sulfate (HS), which is degraded by heparanase, plays an important role in cell adhesion, insolubility of the extracellular matrix (ECM) and as a reservoir for various growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF).	Heparitin Sulfate	17-19	fibroblast growth factor 2	Homo sapiens	198-228
15260846-1	2004	Heparan sulfate (HS), which is degraded by heparanase, plays an important role in cell adhesion, insolubility of the extracellular matrix (ECM) and as a reservoir for various growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF).	Heparitin Sulfate	17-19	fibroblast growth factor 2	Homo sapiens	230-234
15260846-1	2004	Heparan sulfate (HS), which is degraded by heparanase, plays an important role in cell adhesion, insolubility of the extracellular matrix (ECM) and as a reservoir for various growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF).	Heparitin Sulfate	17-19	vascular endothelial growth factor A	Homo sapiens	240-274
15260846-1	2004	Heparan sulfate (HS), which is degraded by heparanase, plays an important role in cell adhesion, insolubility of the extracellular matrix (ECM) and as a reservoir for various growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF).	Heparitin Sulfate	17-19	vascular endothelial growth factor A	Homo sapiens	276-280
15279603-1	2004	Heparanase is an endo-beta-glucuronidase that degrades the glycosaminoglycan heparan sulfate, a major component of the extracellular matrix and basement membranes, and has been implicated in such processes as inflammation, angiogenesis and metastasis.	Heparitin Sulfate	77-92	glucuronidase beta	Homo sapiens	22-40
15161920-2	2004	The EXT1 and EXT2 genes encode glycosyltransferases that play an essential role in heparan sulfate chain elongation.	Heparitin Sulfate	83-98	exostosin glycosyltransferase 1	Mus musculus	4-8
15161920-2	2004	The EXT1 and EXT2 genes encode glycosyltransferases that play an essential role in heparan sulfate chain elongation.	Heparitin Sulfate	83-98	exostosin glycosyltransferase 2	Mus musculus	13-17
15161920-3	2004	In this study, we have analyzed heparan sulfate synthesized by primary fibroblast cell cultures established from mice with a gene trap mutation in Ext1.	Heparitin Sulfate	32-47	exostosin glycosyltransferase 1	Mus musculus	147-151
15161920-5	2004	Metabolic labeling and immunohistochemistry revealed that Ext1 mutant fibroblasts still produced small amounts of heparan sulfate.	Heparitin Sulfate	114-129	exostosin glycosyltransferase 1	Mus musculus	58-62
15161920-8	2004	The average molecular sizes of the heparan sulfate chains from wild type and Ext1 mutant embryonic fibroblasts were estimated to be around 70 and 20 kDa, respectively.	Heparitin Sulfate	35-50	exostosin glycosyltransferase 1	Mus musculus	77-81
15280800-3	2004	EC-SOD is a secretory, tetrameric glycoprotein containing copper and zinc, with a high affinity to certain glycosaminoglycans, such as heparin and heparan sulfate.	Heparitin Sulfate	147-162	superoxide dismutase 3	Homo sapiens	0-6
15138272-0	2004	Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation.	Heparitin Sulfate	50-65	histidine rich glycoprotein	Homo sapiens	0-27
15246697-1	2004	Exostosin tumor-like 3 (EXTL3) is a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	68-83	exostosin-like glycosyltransferase 3	Mus musculus	0-22
15246697-1	2004	Exostosin tumor-like 3 (EXTL3) is a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	68-83	exostosin-like glycosyltransferase 3	Mus musculus	24-29
15246697-1	2004	Exostosin tumor-like 3 (EXTL3) is a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	68-83	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	36-55
15246697-1	2004	Exostosin tumor-like 3 (EXTL3) is a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	85-87	exostosin-like glycosyltransferase 3	Mus musculus	0-22
15246697-1	2004	Exostosin tumor-like 3 (EXTL3) is a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	85-87	exostosin-like glycosyltransferase 3	Mus musculus	24-29
15246697-1	2004	Exostosin tumor-like 3 (EXTL3) is a glycosyltransferase involved in heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	85-87	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	36-55
15138272-8	2004	These data suggest that heparan sulfate is the predominate cell-surface ligand for HRG and that mammalian heparanase is a potential regulator of HRG binding.	Heparitin Sulfate	24-39	histidine rich glycoprotein	Homo sapiens	83-86
15138272-9	2004	Using recombinant forms of full-length HRG and the N-terminal N1N2 domain, it was shown that the N1N2 domain bound specifically to immobilized heparin and cell-surface heparan sulfate.	Heparitin Sulfate	168-183	histidine rich glycoprotein	Homo sapiens	39-42
15211644-0	2004	An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer"s disease.	Heparitin Sulfate	46-61	heparan sulfate proteoglycan 2	Homo sapiens	91-96
15177184-6	2004	The protein kinase activity of ATM was selectively inhibited by wortmannin, caffeine and LY294002 and was stimulated by charged biological polymers, including single-stranded M13 DNA (ssDNA), sheared double-stranded calf thymus DNA, heparin sulfate and poly ADP-ribose (PAR), raising the possibility that charged structures may contribute to regulation of ATM activity.	Heparitin Sulfate	233-248	ATM serine/threonine kinase	Bos taurus	31-34
15133030-7	2004	Heparan sulfate-like proteoglycans on these tumor cell surfaces are implicated in adhesion of the tumor cells to P-selectin.	Heparitin Sulfate	0-15	selectin P	Homo sapiens	113-123
15211644-1	2004	Accumulating evidence indicates that the heparan-sulfate-proteoglycan (perlecan, HSPG2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in Alzheimer"s disease (AD).	Heparitin Sulfate	41-56	heparan sulfate proteoglycan 2	Homo sapiens	81-86
15211644-1	2004	Accumulating evidence indicates that the heparan-sulfate-proteoglycan (perlecan, HSPG2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in Alzheimer"s disease (AD).	Heparitin Sulfate	41-56	microtubule associated protein tau	Homo sapiens	166-169
15211644-4	2004	We performed a case-control association study between the common intron 6 BamHI polymorphism at a region of putative heparan-sulfate (HS) attachment sites in the HSPG2 gene and sporadic AD in Jews.	Heparitin Sulfate	117-132	heparan sulfate proteoglycan 2	Homo sapiens	162-167
15186946-0	2004	Removal of heparan sulfate by heparinase treatment inhibits FGF-2-dependent smooth muscle cell proliferation in injured rat carotid arteries.	Heparitin Sulfate	11-26	fibroblast growth factor 2	Rattus norvegicus	60-65
15186946-2	2004	The interaction of fibroblast growth factor (FGF-2), which is released at the site of injury, with heparan sulfate proteoglycans (HSPGs) is necessary to induce signaling, which elicits an FGF-dependent mitogenic response by arterial smooth muscle cells, and also serves as a mechanism for storage of the growth factor within the extracellular matrix.	Heparitin Sulfate	99-114	fibroblast growth factor 2	Rattus norvegicus	45-50
15198666-2	2004	Agrin"s neurite inhibitory activity is confined to the N-terminal segment of the protein (agrin N150), which contains heparan sulfate (HS) and chondroitin sulfate (CS) side chains.	Heparitin Sulfate	118-133	agrin	Gallus gallus	0-5
15245589-3	2004	An endo-beta-D-glucuronidase, heparanase, is capable of specifically degrading one of the ECM components, heparan sulfate, and this activity is associated with the metastatic potential of tumor cells.	Heparitin Sulfate	106-121	glucuronidase beta	Homo sapiens	8-28
15245589-3	2004	An endo-beta-D-glucuronidase, heparanase, is capable of specifically degrading one of the ECM components, heparan sulfate, and this activity is associated with the metastatic potential of tumor cells.	Heparitin Sulfate	106-121	heparanase	Homo sapiens	30-40
15044385-0	2004	The heparan sulfate-specific epitope 10E4 is NO-sensitive and partly inaccessible in glypican-1.	Heparitin Sulfate	4-19	glypican 1	Homo sapiens	85-95
15231666-2	2004	Within the fibroblast growth factor (FGF) family, signaling to an epithelial cell-specific FGF receptor (FGFR) 2IIIb-heparan sulfate complex from stromal-specific FGF7 and FGF10 delivers directionally specific instruction from stroma to epithelium without autocrine interference.	Heparitin Sulfate	117-132	fibroblast growth factor 7	Rattus norvegicus	163-167
15231666-2	2004	Within the fibroblast growth factor (FGF) family, signaling to an epithelial cell-specific FGF receptor (FGFR) 2IIIb-heparan sulfate complex from stromal-specific FGF7 and FGF10 delivers directionally specific instruction from stroma to epithelium without autocrine interference.	Heparitin Sulfate	117-132	fibroblast growth factor 10	Rattus norvegicus	172-177
15198666-2	2004	Agrin"s neurite inhibitory activity is confined to the N-terminal segment of the protein (agrin N150), which contains heparan sulfate (HS) and chondroitin sulfate (CS) side chains.	Heparitin Sulfate	118-133	agrin	Gallus gallus	90-95
15198666-2	2004	Agrin"s neurite inhibitory activity is confined to the N-terminal segment of the protein (agrin N150), which contains heparan sulfate (HS) and chondroitin sulfate (CS) side chains.	Heparitin Sulfate	135-137	agrin	Gallus gallus	0-5
15198666-2	2004	Agrin"s neurite inhibitory activity is confined to the N-terminal segment of the protein (agrin N150), which contains heparan sulfate (HS) and chondroitin sulfate (CS) side chains.	Heparitin Sulfate	135-137	agrin	Gallus gallus	90-95
15163732-4	2004	The K8.1 glycoprotein is a structural component of the KSHV particle and is thought to facilitate virus entry by binding to heparan sulfate moieties on cell surfaces.	Heparitin Sulfate	124-139	K8.1	Human gammaherpesvirus 8	4-8
15223860-0	2004	Epithelial expression and release of FGF-2 from heparan sulphate binding sites in bronchial tissue in asthma.	Heparitin Sulfate	48-64	fibroblast growth factor 2	Homo sapiens	37-42
15082721-7	2004	Overexpression of the hfrc1 gene in HCT116 cells modulated the cell surface heparan sulfate expression status.	Heparitin Sulfate	76-91	solute carrier family 35 member D2	Homo sapiens	22-27
15082721-8	2004	These results suggest that HFRC1 takes part in the synthesis of heparan sulfate by regulating the level of UDP-GlcNAc, a donor substrate for the heparan sulfate synthases.	Heparitin Sulfate	64-79	solute carrier family 35 member D2	Homo sapiens	27-32
15146460-1	2004	Mucopolysaccharidosis type IIIA (MPSIIIA) is an autosomal recessive lysosomal storage disease caused by mutations in the N-sulfoglucosamine sulfohydrolase gene (SGSH; encoding sulfamidase, also sulphamidase) leading to the lysosomal accumulation and urinary excretion of heparan sulfate.	Heparitin Sulfate	271-286	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-31
15146460-1	2004	Mucopolysaccharidosis type IIIA (MPSIIIA) is an autosomal recessive lysosomal storage disease caused by mutations in the N-sulfoglucosamine sulfohydrolase gene (SGSH; encoding sulfamidase, also sulphamidase) leading to the lysosomal accumulation and urinary excretion of heparan sulfate.	Heparitin Sulfate	271-286	N-sulfoglucosamine sulfohydrolase	Homo sapiens	121-159
15146460-1	2004	Mucopolysaccharidosis type IIIA (MPSIIIA) is an autosomal recessive lysosomal storage disease caused by mutations in the N-sulfoglucosamine sulfohydrolase gene (SGSH; encoding sulfamidase, also sulphamidase) leading to the lysosomal accumulation and urinary excretion of heparan sulfate.	Heparitin Sulfate	271-286	N-sulfoglucosamine sulfohydrolase	Homo sapiens	161-165
15291107-1	2004	OBJECTIVE: The beta-D-endoglycosidase heparanase (Hpa) is HS-specific which leads to heparan sulfate (HS) degradation.	Heparitin Sulfate	85-100	heparanase	Rattus norvegicus	38-48
15291107-1	2004	OBJECTIVE: The beta-D-endoglycosidase heparanase (Hpa) is HS-specific which leads to heparan sulfate (HS) degradation.	Heparitin Sulfate	85-100	heparanase	Rattus norvegicus	50-53
15291107-1	2004	OBJECTIVE: The beta-D-endoglycosidase heparanase (Hpa) is HS-specific which leads to heparan sulfate (HS) degradation.	Heparitin Sulfate	58-60	heparanase	Rattus norvegicus	38-48
15291107-1	2004	OBJECTIVE: The beta-D-endoglycosidase heparanase (Hpa) is HS-specific which leads to heparan sulfate (HS) degradation.	Heparitin Sulfate	58-60	heparanase	Rattus norvegicus	50-53
15060080-1	2004	Heparan sulfate interacts with antithrombin, a protease inhibitor, to regulate blood coagulation.	Heparitin Sulfate	0-15	serpin family C member 1	Homo sapiens	31-43
15060080-3	2004	This enzyme transfers the sulfuryl group (SO(3)) from 3"-phosphoadenosine 5"-phosphosulfate to the 3-OH position of a glucosamine residue to form the 3-O-sulfo glucosamine, a structural motif critical for binding of heparan sulfate to antithrombin.	Heparitin Sulfate	216-231	serpin family C member 1	Homo sapiens	235-247
15177029-0	2004	Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.	Heparitin Sulfate	15-30	exostosin glycosyltransferase 1	Homo sapiens	0-4
15177029-0	2004	Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.	Heparitin Sulfate	15-30	Indian hedgehog signaling molecule	Homo sapiens	54-57
15177029-1	2004	Exostosin1 (Ext1) belongs to a family of glycosyltransferases necessary for the synthesis of the heparan sulfate (HS) chains of proteoglycans, which regulate signaling of several growth factors.	Heparitin Sulfate	97-112	exostosin glycosyltransferase 1	Homo sapiens	0-10
15177029-1	2004	Exostosin1 (Ext1) belongs to a family of glycosyltransferases necessary for the synthesis of the heparan sulfate (HS) chains of proteoglycans, which regulate signaling of several growth factors.	Heparitin Sulfate	97-112	exostosin glycosyltransferase 1	Homo sapiens	12-16
15177029-1	2004	Exostosin1 (Ext1) belongs to a family of glycosyltransferases necessary for the synthesis of the heparan sulfate (HS) chains of proteoglycans, which regulate signaling of several growth factors.	Heparitin Sulfate	114-116	exostosin glycosyltransferase 1	Homo sapiens	0-10
15177029-1	2004	Exostosin1 (Ext1) belongs to a family of glycosyltransferases necessary for the synthesis of the heparan sulfate (HS) chains of proteoglycans, which regulate signaling of several growth factors.	Heparitin Sulfate	114-116	exostosin glycosyltransferase 1	Homo sapiens	12-16
15177029-3	2004	In contrast, we show that reduced HS synthesis in mice carrying a hypomorphic mutation in Ext1 results in an elevated range of Indian hedgehog (Ihh) signaling during embryonic chondrocyte differentiation.	Heparitin Sulfate	34-36	exostosin glycosyltransferase 1	Mus musculus	90-94
15177029-3	2004	In contrast, we show that reduced HS synthesis in mice carrying a hypomorphic mutation in Ext1 results in an elevated range of Indian hedgehog (Ihh) signaling during embryonic chondrocyte differentiation.	Heparitin Sulfate	34-36	Indian hedgehog	Mus musculus	144-147
15084524-1	2004	Previous studies have suggested that heparan sulfate proteoglycans (HSPGs) play a role in deposition of beta-amyloid protein (Abeta) in the Alzheimer"s disease (AD) brain.	Heparitin Sulfate	37-52	amyloid beta precursor protein	Homo sapiens	126-131
15084524-2	2004	In the present study, we demonstrated that glypican-1 can bind fibrillar Abeta, and the binding is mainly mediated by heparan sulfate (HS) chains.	Heparitin Sulfate	118-133	glypican 1	Homo sapiens	43-53
15084524-2	2004	In the present study, we demonstrated that glypican-1 can bind fibrillar Abeta, and the binding is mainly mediated by heparan sulfate (HS) chains.	Heparitin Sulfate	118-133	amyloid beta precursor protein	Homo sapiens	73-78
15084524-2	2004	In the present study, we demonstrated that glypican-1 can bind fibrillar Abeta, and the binding is mainly mediated by heparan sulfate (HS) chains.	Heparitin Sulfate	135-137	glypican 1	Homo sapiens	43-53
15084524-2	2004	In the present study, we demonstrated that glypican-1 can bind fibrillar Abeta, and the binding is mainly mediated by heparan sulfate (HS) chains.	Heparitin Sulfate	135-137	amyloid beta precursor protein	Homo sapiens	73-78
15296942-1	2004	Perlecan is a highly conserved heparan sulfate proteoglycan in cartilage and basement membranes.	Heparitin Sulfate	31-46	heparan sulfate proteoglycan 2	Gallus gallus	0-8
15056609-0	2004	Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways.	Heparitin Sulfate	14-29	hedgehog	Drosophila melanogaster	77-85
15296942-3	2004	Chick perlecan is, like its human and mouse homologue, a hybrid heparan sulfate/chondroitin sulfate proteoglycan with a core protein of 400 KD.	Heparitin Sulfate	64-79	heparan sulfate proteoglycan 2	Gallus gallus	6-14
15081013-3	2004	The affinities of these heparan sulfate (HS) mimetics for the HS-binding fibroblast growth factors FGF-1 and FGF-2 were measured via a surface plasmon resonance solution affinity assay.	Heparitin Sulfate	24-39	fibroblast growth factor 1	Homo sapiens	99-104
15081013-3	2004	The affinities of these heparan sulfate (HS) mimetics for the HS-binding fibroblast growth factors FGF-1 and FGF-2 were measured via a surface plasmon resonance solution affinity assay.	Heparitin Sulfate	24-39	fibroblast growth factor 2	Homo sapiens	109-114
15081013-3	2004	The affinities of these heparan sulfate (HS) mimetics for the HS-binding fibroblast growth factors FGF-1 and FGF-2 were measured via a surface plasmon resonance solution affinity assay.	Heparitin Sulfate	41-43	fibroblast growth factor 1	Homo sapiens	99-104
15081013-3	2004	The affinities of these heparan sulfate (HS) mimetics for the HS-binding fibroblast growth factors FGF-1 and FGF-2 were measured via a surface plasmon resonance solution affinity assay.	Heparitin Sulfate	41-43	fibroblast growth factor 2	Homo sapiens	109-114
15112050-5	2004	When glypican-1 is exposed to ascorbate, nitric oxide is released and participates in deaminative cleavage of heparan sulfate at sites where the glucosamines have a free amino group.	Heparitin Sulfate	110-125	glypican 1	Homo sapiens	5-15
15282658-3	2004	Gathering evidence suggests that unlike other chemokines that bind to specific receptors, PF4"s biology depends on its unusually high affinity for heparan sulfates and other negatively charged molecules at concentrations attained in the immediate vicinity of activated platelets.	Heparitin Sulfate	147-163	platelet factor 4	Homo sapiens	90-93
15282658-5	2004	We propose that the main biological role of PF4 and the basis for its presence in the alpha granules of all known mammalian platelets is to neutralize surface heparan sulfate side-chains of glycosaminoglycans and to optimize thrombus development at sites of vascular injury.	Heparitin Sulfate	159-174	platelet factor 4	Homo sapiens	44-47
15056214-3	2004	The brucellae adhered to epithelial cells forming localized bacterial microcolonies on the cell surface, and this process was inhibited significantly by pretreatment of epithelial cells with neuraminidase and sodium periodate and by preincubation of the bacteria with heparan sulphate and N-acetylneuraminic acid.	Heparitin Sulfate	268-284	neuraminidase 1	Homo sapiens	191-204
15056609-0	2004	Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways.	Heparitin Sulfate	14-29	decapentaplegic	Drosophila melanogaster	90-105
15096036-1	2004	The 3-O-sulfation of glucosamine by heparan sulfate 3-O-sulfotransferase-1 (3-OST-1) is a key modification step during the biosynthesis of anticoagulant heparan sulfate (HS).	Heparitin Sulfate	36-51	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	76-83
14977552-5	2004	Here we review recent progress on the role of the cell surface heparan sulfate proteoglycan syndecan-2 and ephrin-Eph signaling in dendritic spine development.	Heparitin Sulfate	63-78	syndecan 2	Homo sapiens	92-102
14718373-2	2004	In a lysosomal storage disorder known as mucopolysaccharidosis I, caused by a deficiency of the exohydrolase alpha-l-iduronidase, fragments of two different glycosaminoglycans, dermatan sulfate and heparan sulfate, have been shown to accumulate.	Heparitin Sulfate	198-213	alpha-L-iduronidase	Homo sapiens	109-128
15034597-2	2004	The presence of two potential nuclear localization sequences in human heparanase, led us to investigate heparanase translocation into the nucleus and subsequent degradation of nuclear heparan sulfate.	Heparitin Sulfate	184-199	heparanase	Homo sapiens	70-80
15034597-4	2004	Our results indicate that nuclear heparanase colocalizes with nuclear heparan sulfate and is enzymaticaly active.	Heparitin Sulfate	70-85	heparanase	Homo sapiens	34-44
15034597-5	2004	Moreover, following uptake of latent 65 kDa heparanase by cells that do not express the enzyme, an active 50 kDa heparanase was detected in the cell nucleus, capable of degrading both nuclear and extracellular matrix-derived heparan sulfate.	Heparitin Sulfate	225-240	heparanase	Homo sapiens	44-54
15034597-5	2004	Moreover, following uptake of latent 65 kDa heparanase by cells that do not express the enzyme, an active 50 kDa heparanase was detected in the cell nucleus, capable of degrading both nuclear and extracellular matrix-derived heparan sulfate.	Heparitin Sulfate	225-240	heparanase	Homo sapiens	113-123
15034597-7	2004	Taken together, it appears that heparanase is translocated into the cell nucleus where it may degrade the nuclear heparan sulfate and thereby affect nuclear functions that are thought to be regulated by heparan sulfate.	Heparitin Sulfate	114-129	heparanase	Homo sapiens	32-42
15034597-7	2004	Taken together, it appears that heparanase is translocated into the cell nucleus where it may degrade the nuclear heparan sulfate and thereby affect nuclear functions that are thought to be regulated by heparan sulfate.	Heparitin Sulfate	203-218	heparanase	Homo sapiens	32-42
15096036-1	2004	The 3-O-sulfation of glucosamine by heparan sulfate 3-O-sulfotransferase-1 (3-OST-1) is a key modification step during the biosynthesis of anticoagulant heparan sulfate (HS).	Heparitin Sulfate	170-172	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	36-74
15096036-1	2004	The 3-O-sulfation of glucosamine by heparan sulfate 3-O-sulfotransferase-1 (3-OST-1) is a key modification step during the biosynthesis of anticoagulant heparan sulfate (HS).	Heparitin Sulfate	170-172	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	76-83
15179029-5	2004	Recent developments indicate that the closely related syndecan-2 and -4 have separable functions, though both bind a number of ligands through their heparan sulfate chains.	Heparitin Sulfate	149-164	syndecan 2	Homo sapiens	54-71
15096036-2	2004	In this paper, we present evidence of a conformational change that occurs in 3-OST-1 upon binding to heparan sulfate.	Heparitin Sulfate	101-116	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	77-84
15096036-3	2004	The intrinsic fluorescence of 3-OST-1 was increased in the presence of HS, suggesting a conformational change.	Heparitin Sulfate	71-73	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	30-37
14645250-0	2004	Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin.	Heparitin Sulfate	32-47	bone morphogenetic protein 1	Homo sapiens	87-113
15063111-0	2004	Attenuation of Sindbis virus variants incorporating uncleaved PE2 glycoprotein is correlated with attachment to cell-surface heparan sulfate.	Heparitin Sulfate	125-140	ETS2 repressor factor	Homo sapiens	62-65
15063111-1	2004	Sindbis virus virions incorporating uncleaved precursor envelope protein PE2 bind efficiently to cell-surface heparan sulfate (HS) because the furin cleavage site (a consensus HS-binding domain) is retained in the mature virus particle.	Heparitin Sulfate	110-125	ETS2 repressor factor	Homo sapiens	73-76
15063111-1	2004	Sindbis virus virions incorporating uncleaved precursor envelope protein PE2 bind efficiently to cell-surface heparan sulfate (HS) because the furin cleavage site (a consensus HS-binding domain) is retained in the mature virus particle.	Heparitin Sulfate	127-129	ETS2 repressor factor	Homo sapiens	73-76
15063111-6	2004	We hypothesize that HS binding leads to sequestration of PE2 noncleaving virus particles and suppression of serum viremia, thereby selecting for evolution of the virus into a PE2-cleaving, low HS-binding phenotype.	Heparitin Sulfate	20-22	ETS2 repressor factor	Homo sapiens	57-60
15063111-6	2004	We hypothesize that HS binding leads to sequestration of PE2 noncleaving virus particles and suppression of serum viremia, thereby selecting for evolution of the virus into a PE2-cleaving, low HS-binding phenotype.	Heparitin Sulfate	20-22	ETS2 repressor factor	Homo sapiens	175-178
14718527-1	2004	Glucuronyl C5-epimerase catalyzes the conversion of d-glucuronic acid to l-iduronic acid units in heparan sulfate biosynthesis.	Heparitin Sulfate	98-113	glucuronic acid epimerase	Homo sapiens	0-23
14735305-6	2004	We investigated the AQP4 expression in human glioblastoma and correlated it with the expression pattern of the extracellular heparan sulfate proteoglycan agrin and members of the dystrophin-dystroglycan complex.	Heparitin Sulfate	125-140	aquaporin 4	Homo sapiens	20-24
15172035-6	2004	Association of exogenously added tropoelastin to the cellular extracellular matrix was inhibited by the addition of heparan sulfate but not chondroitin sulfate sugars.	Heparitin Sulfate	116-131	elastin	Homo sapiens	33-45
14701864-0	2004	ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.	Heparitin Sulfate	234-249	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	0-7
14701864-0	2004	ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.	Heparitin Sulfate	234-249	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	9-22
14967027-1	2004	The aim of this study was to investigate the mechanism of activation of human heparanase, a key player in heparan sulfate degradation, thought to be involved in normal and pathologic cell migration processes.	Heparitin Sulfate	106-121	heparanase	Homo sapiens	78-88
14707131-9	2004	Octasaccharides with the high affinity to FGF-2 and FGF-10 had the activity to release them, respectively, from their complexes with HS.	Heparitin Sulfate	133-135	fibroblast growth factor 2	Homo sapiens	42-47
14707131-9	2004	Octasaccharides with the high affinity to FGF-2 and FGF-10 had the activity to release them, respectively, from their complexes with HS.	Heparitin Sulfate	133-135	fibroblast growth factor 10	Homo sapiens	52-58
14707133-0	2004	Involvement of glycosylphosphatidylinositol-linked ceruloplasmin in the copper/zinc-nitric oxide-dependent degradation of glypican-1 heparan sulfate in rat C6 glioma cells.	Heparitin Sulfate	133-148	ceruloplasmin	Rattus norvegicus	51-64
14707133-0	2004	Involvement of glycosylphosphatidylinositol-linked ceruloplasmin in the copper/zinc-nitric oxide-dependent degradation of glypican-1 heparan sulfate in rat C6 glioma cells.	Heparitin Sulfate	133-148	glypican 1	Rattus norvegicus	122-132
14707133-1	2004	The core protein of glypican-1, a glycosylphosphatidylinositol-linked heparan sulfate proteoglycan, can bind Cu(II) or Zn(II) ions and undergo S-nitrosylation in the presence of nitric oxide.	Heparitin Sulfate	70-85	glypican 1	Rattus norvegicus	20-30
14707133-10	2004	However, in the presence of Cu(II)-loaded ceruloplasmin, heparan sulfate in Zn(II)-loaded glypican-1 underwent extensive, ascorbate-induced degradation.	Heparitin Sulfate	57-72	ceruloplasmin	Rattus norvegicus	42-55
14707133-10	2004	However, in the presence of Cu(II)-loaded ceruloplasmin, heparan sulfate in Zn(II)-loaded glypican-1 underwent extensive, ascorbate-induced degradation.	Heparitin Sulfate	57-72	glypican 1	Rattus norvegicus	90-100
14702351-2	2004	The heparan sulfate binding domains (HSBD) of ColQ are thought to be involved in anchoring ColQ to the synaptic basal lamina.	Heparitin Sulfate	4-19	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	46-50
14702351-2	2004	The heparan sulfate binding domains (HSBD) of ColQ are thought to be involved in anchoring ColQ to the synaptic basal lamina.	Heparitin Sulfate	4-19	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	91-95
15004189-2	2004	Heparanase, the heparan sulfate-specific endo-beta-glucuronidase, has previously been shown to be a key enzyme in melanoma invasion, yet its involvement in monocyte extravasation has not been elucidated.	Heparitin Sulfate	16-31	glucuronidase beta	Homo sapiens	46-64
14701864-5	2004	Specific glycosaminoglycan lyase digestions, followed by product analyses using fluorescence-assisted carbohydrate electrophoresis and immunoprecipitation experiments, showed that the p53 form is associated with syndecan-1 through both chondroitin sulfate and heparan sulfate.	Heparitin Sulfate	260-275	tumor protein p53	Homo sapiens	184-187
14701864-5	2004	Specific glycosaminoglycan lyase digestions, followed by product analyses using fluorescence-assisted carbohydrate electrophoresis and immunoprecipitation experiments, showed that the p53 form is associated with syndecan-1 through both chondroitin sulfate and heparan sulfate.	Heparitin Sulfate	260-275	syndecan 1	Homo sapiens	212-222
15016071-1	2004	Glypican-1, a glycosyl phosphatidyl inositol (GPI)-anchored heparan sulphate proteoglycan expressed in the developing and mature cells of the central nervous system, acts as a coreceptor for diverse ligands, including slit axonal guidance proteins, fibroblast growth factors and laminin.	Heparitin Sulfate	60-76	glypican 1	Rattus norvegicus	0-10
14630925-1	2004	Heparanase (HPSE-1) is involved in the degradation of both cell-surface and extracellular matrix (ECM) heparan sulfate (HS) in normal and neoplastic tissues.	Heparitin Sulfate	103-118	heparanase	Homo sapiens	12-18
14630925-1	2004	Heparanase (HPSE-1) is involved in the degradation of both cell-surface and extracellular matrix (ECM) heparan sulfate (HS) in normal and neoplastic tissues.	Heparitin Sulfate	120-122	heparanase	Homo sapiens	12-18
14630925-4	2004	The mechanism of HPSE-1 action to promote tumor progression may involve multiple substrates because HS is present on both cell-surface and ECM proteoglycans.	Heparitin Sulfate	100-102	heparanase	Homo sapiens	17-23
14751231-0	2004	Quantitative assessment of FGF regulation by cell surface heparan sulfates.	Heparitin Sulfate	58-74	fibroblast growth factor 1	Mus musculus	27-30
14751231-1	2004	Heparin/heparan sulfate-like glycosaminoglycans (HSGAGs) modulate the activity of the fibroblast growth factor (FGF) family of proteins.	Heparitin Sulfate	8-23	fibroblast growth factor 1	Mus musculus	112-115
14751231-3	2004	We describe a methodology to examine the impact of heparan sulfate fine structure and source on FGF-mediated signaling.	Heparitin Sulfate	51-66	fibroblast growth factor 1	Mus musculus	96-99
14645250-0	2004	Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin.	Heparitin Sulfate	32-47	noggin	Homo sapiens	125-131
14645250-2	2004	Here we report that the binding of Noggin to the cell surface is highly selective for heparan sulfate and that specific structural features are required for the interaction.	Heparitin Sulfate	86-101	noggin	Homo sapiens	35-41
14645250-6	2004	This shows that Noggin binds to the S domains of heparan sulfate and provides evidence that, in addition to modulating Wnt signaling in vivo by the release of heparan sulfate bound Wnt, Qsulf1 also modulates BMP signaling by the release of surface-bound Noggin.	Heparitin Sulfate	49-64	noggin	Homo sapiens	16-22
14645250-6	2004	This shows that Noggin binds to the S domains of heparan sulfate and provides evidence that, in addition to modulating Wnt signaling in vivo by the release of heparan sulfate bound Wnt, Qsulf1 also modulates BMP signaling by the release of surface-bound Noggin.	Heparitin Sulfate	159-174	noggin	Homo sapiens	16-22
14729575-4	2004	We show that Dally and Dally-like (Dly), two Drosophila glypican members of the heparan sulphate proteoglycan (HSPG) family, are the substrates of Ttv and are essential for Hh movement.	Heparitin Sulfate	80-96	division abnormally delayed	Drosophila melanogaster	13-18
14761655-0	2004	Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling.	Heparitin Sulfate	0-15	Syndecan	Drosophila melanogaster	29-37
14761655-0	2004	Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling.	Heparitin Sulfate	0-15	roundabout 1	Drosophila melanogaster	83-87
14761655-4	2004	Biochemical studies suggest that guidance activity requires cell-surface heparan sulfate to promote binding of mammalian Slit/Robo homologs.	Heparitin Sulfate	73-88	roundabout 1	Drosophila melanogaster	126-130
14684627-6	2004	The FGF2 activation of ERK1/2 in the absence of receptor activity was completely dependent on heparan sulfate, because this activity was abolished by heparinase III digestion of the cells.	Heparitin Sulfate	94-109	fibroblast growth factor 2	Homo sapiens	4-8
14684627-6	2004	The FGF2 activation of ERK1/2 in the absence of receptor activity was completely dependent on heparan sulfate, because this activity was abolished by heparinase III digestion of the cells.	Heparitin Sulfate	94-109	mitogen-activated protein kinase 3	Homo sapiens	23-29
14729575-4	2004	We show that Dally and Dally-like (Dly), two Drosophila glypican members of the heparan sulphate proteoglycan (HSPG) family, are the substrates of Ttv and are essential for Hh movement.	Heparitin Sulfate	80-96	dally-like	Drosophila melanogaster	23-33
14729575-4	2004	We show that Dally and Dally-like (Dly), two Drosophila glypican members of the heparan sulphate proteoglycan (HSPG) family, are the substrates of Ttv and are essential for Hh movement.	Heparitin Sulfate	80-96	hedgehog	Drosophila melanogaster	173-175
14570917-10	2004	These results suggest that VEGF may be stored in the extracellular matrix via interactions with fibronectin and heparan sulfate in tissues that are in need of vascularization so that it can aid in directing the dynamic process of growth and migration of new blood vessels.	Heparitin Sulfate	112-127	vascular endothelial growth factor A	Homo sapiens	27-31
15009704-7	2004	CD44, a cell surface receptor known to bind hyaluronan, not infrequently exists as a proteoglycan, decorated with various glycosaminoglycan chains including heparan sulfate and chondroitin sulfate, and as such can bind fibronectin.	Heparitin Sulfate	157-172	CD44 molecule (Indian blood group)	Homo sapiens	0-4
14585835-0	2004	Characterization of endostatin binding to heparin and heparan sulfate by surface plasmon resonance and molecular modeling: role of divalent cations.	Heparitin Sulfate	54-69	collagen type XVIII alpha 1 chain	Homo sapiens	20-30
14585835-3	2004	Here we determined the kinetics and affinity of the interaction of endostatin with heparin/heparan sulfate and investigated the effects of divalent cations on these interactions and on the biological activities of endostatin.	Heparitin Sulfate	91-106	collagen type XVIII alpha 1 chain	Homo sapiens	67-77
14585835-4	2004	The binding of human recombinant endostatin to heparin and heparan sulfate was studied by surface plasmon resonance using BIAcore technology and further characterized by docking and molecular dynamics simulations.	Heparitin Sulfate	59-74	collagen type XVIII alpha 1 chain	Homo sapiens	33-43
14585835-5	2004	Kinetic data, evaluated using a 1:1 interaction model, showed that heparan sulfate bound to and dissociated from endostatin faster than heparin and that endostatin bound to heparin and heparan sulfate with a moderate affinity (K(D) approximately 2 microm).	Heparitin Sulfate	67-82	collagen type XVIII alpha 1 chain	Homo sapiens	113-123
14585835-5	2004	Kinetic data, evaluated using a 1:1 interaction model, showed that heparan sulfate bound to and dissociated from endostatin faster than heparin and that endostatin bound to heparin and heparan sulfate with a moderate affinity (K(D) approximately 2 microm).	Heparitin Sulfate	185-200	collagen type XVIII alpha 1 chain	Homo sapiens	153-163
14585835-7	2004	The binding of endostatin to heparin and heparan sulfate required the presence of divalent cations.	Heparitin Sulfate	41-56	collagen type XVIII alpha 1 chain	Homo sapiens	15-25
14585835-8	2004	The addition of ZnCl(2) to endostatin enhanced its binding to heparan sulfate by approximately 40% as well as its antiproliferative effect on endothelial cells stimulated by fibroblast growth factor-2, suggesting that this activity is mediated by the binding of endostatin to heparan sulfate.	Heparitin Sulfate	62-77	collagen type XVIII alpha 1 chain	Homo sapiens	27-37
14585835-8	2004	The addition of ZnCl(2) to endostatin enhanced its binding to heparan sulfate by approximately 40% as well as its antiproliferative effect on endothelial cells stimulated by fibroblast growth factor-2, suggesting that this activity is mediated by the binding of endostatin to heparan sulfate.	Heparitin Sulfate	276-291	collagen type XVIII alpha 1 chain	Homo sapiens	27-37
15106730-29	2004	Vaccinated animals generated a specific anti-FGF-2 antibody (titer of 1:5000) that was able to inhibit FGF-2 binding to heparin sulfate in a dose dependent fashion.	Heparitin Sulfate	120-135	fibroblast growth factor 2	Mus musculus	45-50
15106730-29	2004	Vaccinated animals generated a specific anti-FGF-2 antibody (titer of 1:5000) that was able to inhibit FGF-2 binding to heparin sulfate in a dose dependent fashion.	Heparitin Sulfate	120-135	fibroblast growth factor 2	Mus musculus	103-108
14966466-2	2004	Heparan sulfate N-acetylglucosamine N-deacetylase/adenosine 3"-phosphate 5"-phosphosulfate: unsubstituted glucosamine N-sulfotransferase (NDST) is the key enzyme regulating sulfation of GAG chains.	Heparitin Sulfate	0-15	sulfotransferase family 1D, member 1	Rattus norvegicus	118-136
14573609-1	2004	The endo-beta-d-glucuronidase, heparanase, is capable of specifically degrading heparan sulfate, and this activity is associated with the metastatic potential of tumor cells.	Heparitin Sulfate	80-95	heparanase	Homo sapiens	31-41
14627628-0	2004	Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation.	Heparitin Sulfate	0-15	syndecan 3	Mus musculus	96-106
14744776-2	2004	The cell surface heparan sulfate proteoglycan, syndecan-1 (Sdc1), is thought to function as a coreceptor for growth factor and extracellular matrix interactions, and Sdc1 expression is induced in reactive stromal cells in both mice and man.	Heparitin Sulfate	17-32	syndecan 1	Mus musculus	47-57
14744776-2	2004	The cell surface heparan sulfate proteoglycan, syndecan-1 (Sdc1), is thought to function as a coreceptor for growth factor and extracellular matrix interactions, and Sdc1 expression is induced in reactive stromal cells in both mice and man.	Heparitin Sulfate	17-32	syndecan 1	Mus musculus	59-63
14744776-9	2004	The growth-promoting effect was completely abolished when fibroblasts were transfected with mutant Sdc1 lacking heparan sulfate attachment sites.	Heparitin Sulfate	112-127	syndecan 1	Homo sapiens	99-103
14733594-2	2004	We demonstrate that a glycopolymer bearing pendant, fully sulfated lactose units effectively replaces heparin and heparan sulfate as a molecular chaperone for fibroblast growth factor-2 (FGF-2).	Heparitin Sulfate	114-129	fibroblast growth factor 2	Homo sapiens	159-185
14733594-2	2004	We demonstrate that a glycopolymer bearing pendant, fully sulfated lactose units effectively replaces heparin and heparan sulfate as a molecular chaperone for fibroblast growth factor-2 (FGF-2).	Heparitin Sulfate	114-129	fibroblast growth factor 2	Homo sapiens	187-192
14527339-2	2004	By immunoprecipitation using an anti-syndecan-2 antibody on TNF-alpha-stimulated HUVEC lysates, inflammation-induced interleukin-8 was found to be an interaction partner of this HS (heparan sulphate) proteoglycan, but not of any other syndecan on these cells.	Heparitin Sulfate	182-198	syndecan 2	Homo sapiens	37-47
14527339-2	2004	By immunoprecipitation using an anti-syndecan-2 antibody on TNF-alpha-stimulated HUVEC lysates, inflammation-induced interleukin-8 was found to be an interaction partner of this HS (heparan sulphate) proteoglycan, but not of any other syndecan on these cells.	Heparitin Sulfate	182-198	tumor necrosis factor	Homo sapiens	60-69
14527339-2	2004	By immunoprecipitation using an anti-syndecan-2 antibody on TNF-alpha-stimulated HUVEC lysates, inflammation-induced interleukin-8 was found to be an interaction partner of this HS (heparan sulphate) proteoglycan, but not of any other syndecan on these cells.	Heparitin Sulfate	182-198	C-X-C motif chemokine ligand 8	Homo sapiens	117-130
14972565-3	2004	Bovine lactoferrin (BLf) was a strong inhibitor of HSV-1 infection in cells expressing either heparan sulfate (HS) or chondroitin sulfate (CS) or both, but was ineffective or less efficient in GAG-deficient cells or in cells treated with GAG-degrading enzymes.	Heparitin Sulfate	94-109	lactotransferrin	Bos taurus	7-18
14972565-3	2004	Bovine lactoferrin (BLf) was a strong inhibitor of HSV-1 infection in cells expressing either heparan sulfate (HS) or chondroitin sulfate (CS) or both, but was ineffective or less efficient in GAG-deficient cells or in cells treated with GAG-degrading enzymes.	Heparitin Sulfate	51-53	lactotransferrin	Bos taurus	7-18
14972565-5	2004	Finally, we demonstrated that lactoferrin bound directly to both HS and CS isolated from surfaces of the studied cells, as well as to commercial preparations of GAG chains.	Heparitin Sulfate	65-67	lactotransferrin	Bos taurus	30-41
14972565-6	2004	The results support the hypothesis that the inhibition of HSV-1 infectivity by lactoferrin is dependent on its interaction with cell surface GAG chains of HS and CS.	Heparitin Sulfate	58-60	lactotransferrin	Bos taurus	79-90
15702865-1	2004	Fibroblast growth factor-2 is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types.	Heparitin Sulfate	91-106	fibroblast growth factor 2	Homo sapiens	0-26
15672872-1	2004	Heparanase is an endoglycosidase that degrades heparan sulfate (HS) in the extracellular matrix (ECM) and cell surfaces, and fulfills a significant role in cancer metastasis and angiogenesis.	Heparitin Sulfate	47-62	heparanase	Homo sapiens	0-10
15672872-1	2004	Heparanase is an endoglycosidase that degrades heparan sulfate (HS) in the extracellular matrix (ECM) and cell surfaces, and fulfills a significant role in cancer metastasis and angiogenesis.	Heparitin Sulfate	64-66	heparanase	Homo sapiens	0-10
15035435-8	2004	Heparin and heparan sulfate fully protected bFGF from complexation and cleavage by HABP, although these glycosaminoglycans are known to enhance the proteolytic activity of HABP.	Heparitin Sulfate	12-27	fibroblast growth factor 2	Homo sapiens	44-48
15035435-8	2004	Heparin and heparan sulfate fully protected bFGF from complexation and cleavage by HABP, although these glycosaminoglycans are known to enhance the proteolytic activity of HABP.	Heparitin Sulfate	12-27	hyaluronan binding protein 2	Homo sapiens	83-87
14618397-1	2003	EXTL3 encodes alpha1,4-N-acetylglucosaminyltransferases I and II enzymes, which are involved in chain initiation and elongation of heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	131-146	exostosin-like glycosyltransferase 3	Mus musculus	0-5
14688304-5	2004	The ability of heparan sulfate and elastase to induce SIRS depends on functional Toll-like receptor 4, because mutant mice lacking that receptor or its function do not respond.	Heparitin Sulfate	15-30	toll-like receptor 4	Mus musculus	81-101
14522979-1	2003	Cleavage of heparan sulfate by the beta-D-endoglucuronidase heparanase (HPSE) is a fundamental event in a number of important physiological processes including inflammation, wound healing, and angiogenesis.	Heparitin Sulfate	12-27	heparanase	Homo sapiens	60-70
14522979-1	2003	Cleavage of heparan sulfate by the beta-D-endoglucuronidase heparanase (HPSE) is a fundamental event in a number of important physiological processes including inflammation, wound healing, and angiogenesis.	Heparitin Sulfate	12-27	heparanase	Homo sapiens	72-76
14647401-5	2004	Dual color immunofluorescence analysis demonstrated that MCP-1 was focused into heparan sulfate-containing domains on the apical surface of some of the endothelial cells.	Heparitin Sulfate	80-95	C-C motif chemokine ligand 2	Homo sapiens	57-62
14681683-1	2003	Mice with a null mutation in the cell surface heparan sulfate (HS) proteoglycan, syndecan-1 (Sdc1), develop almost normally, but resist mammary tumor development in response to Wnt-1.	Heparitin Sulfate	46-61	syndecan 1	Mus musculus	81-91
14681683-1	2003	Mice with a null mutation in the cell surface heparan sulfate (HS) proteoglycan, syndecan-1 (Sdc1), develop almost normally, but resist mammary tumor development in response to Wnt-1.	Heparitin Sulfate	46-61	syndecan 1	Mus musculus	93-97
14681683-1	2003	Mice with a null mutation in the cell surface heparan sulfate (HS) proteoglycan, syndecan-1 (Sdc1), develop almost normally, but resist mammary tumor development in response to Wnt-1.	Heparitin Sulfate	46-61	wingless-type MMTV integration site family, member 1	Mus musculus	177-182
14681683-1	2003	Mice with a null mutation in the cell surface heparan sulfate (HS) proteoglycan, syndecan-1 (Sdc1), develop almost normally, but resist mammary tumor development in response to Wnt-1.	Heparitin Sulfate	63-65	syndecan 1	Mus musculus	81-91
14681683-1	2003	Mice with a null mutation in the cell surface heparan sulfate (HS) proteoglycan, syndecan-1 (Sdc1), develop almost normally, but resist mammary tumor development in response to Wnt-1.	Heparitin Sulfate	63-65	syndecan 1	Mus musculus	93-97
14681683-1	2003	Mice with a null mutation in the cell surface heparan sulfate (HS) proteoglycan, syndecan-1 (Sdc1), develop almost normally, but resist mammary tumor development in response to Wnt-1.	Heparitin Sulfate	63-65	wingless-type MMTV integration site family, member 1	Mus musculus	177-182
14695190-1	2003	Heparanase is an enzyme that cleaves heparan sulfate chains of proteoglycans, and its expression has been associated with increased growth, metastasis, and angiogenesis of some tumors.	Heparitin Sulfate	37-52	heparanase	Homo sapiens	0-10
14695198-5	2003	Heparanase is an endoglycosidase degrading heparan sulfate, of the basement membrane and extracellular matrix.	Heparitin Sulfate	43-58	heparanase	Homo sapiens	0-10
12816733-0	2003	The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor.	Heparitin Sulfate	4-19	glypican 3	Homo sapiens	33-37
12816733-2	2003	The gene encoding Glypican 3, a glycosylphosphatidylinositol-linked heparan sulfate proteoglycan, was decreased in lung adenocarcinoma.	Heparitin Sulfate	68-83	glypican 3	Homo sapiens	18-28
14618397-1	2003	EXTL3 encodes alpha1,4-N-acetylglucosaminyltransferases I and II enzymes, which are involved in chain initiation and elongation of heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	148-150	exostosin-like glycosyltransferase 3	Mus musculus	0-5
14592998-1	2003	Antithrombin (AT) inhibits thrombin and some other coagulation factors in a reaction that is dramatically accelerated by binding of a pentasaccharide sequence present in heparin/heparan-sulfate to a heparin-binding site on AT.	Heparitin Sulfate	178-193	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	0-12
14623248-6	2003	Treatment of cells with high salt, protamine, heparin, or suramin released significant VEGF, suggesting that heparan sulfate proteoglycan might be sequestering some of the VEGF.	Heparitin Sulfate	109-124	vascular endothelial growth factor A	Mus musculus	87-91
14623248-6	2003	Treatment of cells with high salt, protamine, heparin, or suramin released significant VEGF, suggesting that heparan sulfate proteoglycan might be sequestering some of the VEGF.	Heparitin Sulfate	109-124	vascular endothelial growth factor A	Mus musculus	172-176
14624766-5	2003	Furthermore, heparin and heparan sulfate, but not chondroitin sulfate, inhibited IGFBP-2/IGF-II binding to ECM.	Heparitin Sulfate	25-40	insulin like growth factor binding protein 2	Homo sapiens	81-88
14624766-5	2003	Furthermore, heparin and heparan sulfate, but not chondroitin sulfate, inhibited IGFBP-2/IGF-II binding to ECM.	Heparitin Sulfate	25-40	insulin like growth factor 2	Homo sapiens	89-95
14675190-9	2003	These data suggest that the p200 molecule contains N-glycans but lacks O-linked oligosaccharides and chondroitin/heparan sulfate side chains.	Heparitin Sulfate	113-128	AT-rich interaction domain 2	Homo sapiens	28-32
14727810-2	2003	It is characterized by systemic heparan sulfate accumulation in lysosomes due to deficiency of the enzyme alpha-N-acetylglucosaminidase (Naglu).	Heparitin Sulfate	32-47	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	106-135
14727810-2	2003	It is characterized by systemic heparan sulfate accumulation in lysosomes due to deficiency of the enzyme alpha-N-acetylglucosaminidase (Naglu).	Heparitin Sulfate	32-47	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	137-142
14592998-1	2003	Antithrombin (AT) inhibits thrombin and some other coagulation factors in a reaction that is dramatically accelerated by binding of a pentasaccharide sequence present in heparin/heparan-sulfate to a heparin-binding site on AT.	Heparitin Sulfate	178-193	coagulation factor II	Mus musculus	4-12
14592998-8	2003	This severe thrombotic phenotype underlines a critical function of the heparin-binding site of antithrombin and its interaction with heparin/heparan-sulfate moieties in health, reproduction, and survival, and represents an in vivo model for comparative analysis of heparin-derived and other antithrombotic molecules.	Heparitin Sulfate	141-156	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	95-107
12975379-1	2003	Raji cells expressing syndecan-1 (Raji-S1) adhere and spread when plated on heparan sulfate-binding extracellular matrix ligands or monoclonal antibody 281.2, an antibody directed against the syndecan-1 extracellular domain.	Heparitin Sulfate	76-91	syndecan 1	Homo sapiens	22-32
12972423-4	2003	We have previously shown that the heparan sulfate (HS) side chains of recycling glypican-1 (Gpc-1) can sequester spermine, that intracellular polyamine depletion increases the number of NO-sensitive N-unsubstituted glucosamines in HS, and that NO-dependent cleavage of HS at these sites is required for spermine uptake.	Heparitin Sulfate	34-49	glypican 1	Homo sapiens	80-90
12972423-4	2003	We have previously shown that the heparan sulfate (HS) side chains of recycling glypican-1 (Gpc-1) can sequester spermine, that intracellular polyamine depletion increases the number of NO-sensitive N-unsubstituted glucosamines in HS, and that NO-dependent cleavage of HS at these sites is required for spermine uptake.	Heparitin Sulfate	34-49	glypican 1	Homo sapiens	92-97
12972423-4	2003	We have previously shown that the heparan sulfate (HS) side chains of recycling glypican-1 (Gpc-1) can sequester spermine, that intracellular polyamine depletion increases the number of NO-sensitive N-unsubstituted glucosamines in HS, and that NO-dependent cleavage of HS at these sites is required for spermine uptake.	Heparitin Sulfate	51-53	glypican 1	Homo sapiens	80-90
12972423-4	2003	We have previously shown that the heparan sulfate (HS) side chains of recycling glypican-1 (Gpc-1) can sequester spermine, that intracellular polyamine depletion increases the number of NO-sensitive N-unsubstituted glucosamines in HS, and that NO-dependent cleavage of HS at these sites is required for spermine uptake.	Heparitin Sulfate	51-53	glypican 1	Homo sapiens	92-97
14610063-5	2003	The processed GPC3 core protein is necessary and sufficient for the cell-specific induction of apoptosis, but in vitro effects on canonical and noncanonical Wnt signaling additionally require substitution of the core protein with heparan sulfate.	Heparitin Sulfate	230-245	glypican 3	Homo sapiens	14-18
12972423-4	2003	We have previously shown that the heparan sulfate (HS) side chains of recycling glypican-1 (Gpc-1) can sequester spermine, that intracellular polyamine depletion increases the number of NO-sensitive N-unsubstituted glucosamines in HS, and that NO-dependent cleavage of HS at these sites is required for spermine uptake.	Heparitin Sulfate	231-233	glypican 1	Homo sapiens	80-90
12972423-4	2003	We have previously shown that the heparan sulfate (HS) side chains of recycling glypican-1 (Gpc-1) can sequester spermine, that intracellular polyamine depletion increases the number of NO-sensitive N-unsubstituted glucosamines in HS, and that NO-dependent cleavage of HS at these sites is required for spermine uptake.	Heparitin Sulfate	231-233	glypican 1	Homo sapiens	92-97
12972423-4	2003	We have previously shown that the heparan sulfate (HS) side chains of recycling glypican-1 (Gpc-1) can sequester spermine, that intracellular polyamine depletion increases the number of NO-sensitive N-unsubstituted glucosamines in HS, and that NO-dependent cleavage of HS at these sites is required for spermine uptake.	Heparitin Sulfate	231-233	glypican 1	Homo sapiens	80-90
12972423-4	2003	We have previously shown that the heparan sulfate (HS) side chains of recycling glypican-1 (Gpc-1) can sequester spermine, that intracellular polyamine depletion increases the number of NO-sensitive N-unsubstituted glucosamines in HS, and that NO-dependent cleavage of HS at these sites is required for spermine uptake.	Heparitin Sulfate	231-233	glypican 1	Homo sapiens	92-97
12972423-11	2003	The former bound to the HS chains of recycling Gpc-1 and S-nitrosylated the core protein.	Heparitin Sulfate	24-26	glypican 1	Homo sapiens	47-52
14575696-0	2003	Platelet factor 4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor Xa by preventing interaction(s) of enzyme with polysaccharide.	Heparitin Sulfate	30-45	platelet factor 4	Homo sapiens	0-17
14575696-0	2003	Platelet factor 4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor Xa by preventing interaction(s) of enzyme with polysaccharide.	Heparitin Sulfate	30-45	serpin family C member 1	Homo sapiens	55-67
14575696-0	2003	Platelet factor 4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor Xa by preventing interaction(s) of enzyme with polysaccharide.	Heparitin Sulfate	30-45	coagulation factor X	Homo sapiens	84-93
14575696-2	2003	PF4 also neutralizes heparan sulfate (HS), a glycosaminoglycan (GAG) present on the surface of endothelial cells, thereby possibly modulating an anticoagulant response.	Heparitin Sulfate	21-36	platelet factor 4	Homo sapiens	0-3
14633698-1	2003	Heparanase is an endo-beta-glucuronidase responsible for the cleavage of heparan sulfate, participating in extracellular matrix degradation and remodeling.	Heparitin Sulfate	73-88	heparanase	Homo sapiens	0-10
14633698-1	2003	Heparanase is an endo-beta-glucuronidase responsible for the cleavage of heparan sulfate, participating in extracellular matrix degradation and remodeling.	Heparitin Sulfate	73-88	glucuronidase beta	Homo sapiens	22-40
14624372-6	2003	Inhibitory studies have shown that heparan sulfate moiety of cell-surface proteoglycans is involved in the viral attachment to these CD4-negative epithelial cells.	Heparitin Sulfate	35-50	CD4 molecule	Homo sapiens	133-136
14575696-2	2003	PF4 also neutralizes heparan sulfate (HS), a glycosaminoglycan (GAG) present on the surface of endothelial cells, thereby possibly modulating an anticoagulant response.	Heparitin Sulfate	38-40	platelet factor 4	Homo sapiens	0-3
14610063-5	2003	The processed GPC3 core protein is necessary and sufficient for the cell-specific induction of apoptosis, but in vitro effects on canonical and noncanonical Wnt signaling additionally require substitution of the core protein with heparan sulfate.	Heparitin Sulfate	230-245	Wnt family member 5A	Homo sapiens	157-160
14575696-4	2003	To shed light on the mechanism of PF4, studies of HS/heparin-catalyzed fXa inactivation by AT were undertaken.	Heparitin Sulfate	50-52	coagulation factor X	Homo sapiens	71-74
14610063-7	2003	Our data imply that the Simpson-Golabi-Behmel syndrome may in part result from a loss of GPC3 controls on Wnt signaling, and suggest that this function requires the cooperation of both the protein and the heparan sulfate moieties of the proteoglycan.	Heparitin Sulfate	205-220	glypican 3	Homo sapiens	89-93
14610064-1	2003	Heparan sulfate (HS) interacts with diverse growth factors, including Wnt, Hh, BMP, VEGF, EGF, and FGF family members, and is a necessary component for their signaling.	Heparitin Sulfate	0-15	vascular endothelial growth factor A	Mus musculus	84-88
14610064-1	2003	Heparan sulfate (HS) interacts with diverse growth factors, including Wnt, Hh, BMP, VEGF, EGF, and FGF family members, and is a necessary component for their signaling.	Heparitin Sulfate	17-19	vascular endothelial growth factor A	Mus musculus	84-88
12907690-10	2003	The unique substrate specificity of 3-OST-5 serves as an additional tool to study the mechanism for the biosynthesis of biologically active HS.	Heparitin Sulfate	140-142	heparan sulfate-glucosamine 3-sulfotransferase 5	Homo sapiens	36-43
12907690-6	2003	We isolated IdoUA-AnMan3S and IdoUA-AnMan3S6S from nitrous acid-degraded 3-OST-5-modified HS (pH 1.5), suggesting that 3-OST-5 enzyme sulfates the glucosamine residue that is linked to an iduronic acid residue at the nonreducing end.	Heparitin Sulfate	90-92	heparan sulfate-glucosamine 3-sulfotransferase 5	Homo sapiens	73-80
12907690-6	2003	We isolated IdoUA-AnMan3S and IdoUA-AnMan3S6S from nitrous acid-degraded 3-OST-5-modified HS (pH 1.5), suggesting that 3-OST-5 enzyme sulfates the glucosamine residue that is linked to an iduronic acid residue at the nonreducing end.	Heparitin Sulfate	90-92	heparan sulfate-glucosamine 3-sulfotransferase 5	Homo sapiens	119-126
14605369-4	2003	Furthermore, the EXT1-null brain displayed severe guidance errors in major commissural tracts, revealing a pivotal role of HS in midline axon guidance.	Heparitin Sulfate	123-125	exostosin glycosyltransferase 1	Homo sapiens	17-21
12732629-4	2003	RGD-independent cell adhesion to tTG-FN does not require transamidating activity, is mediated by the binding of tTG to cell-surface heparan sulfate chains, is dependent on the function of protein kinase Calpha, and leads to activation of the cell survival focal adhesion kinase.	Heparitin Sulfate	132-147	transglutaminase 2, C polypeptide	Mus musculus	33-36
14664816-6	2003	The response to FGF-2 upregulation was supported by our finding that FGF receptor-1 (FGFR-1) and heparan sulfate (HS), known to be essential for FGF-2 signaling, were expressed by adult rat RGCs.	Heparitin Sulfate	97-112	fibroblast growth factor 2	Rattus norvegicus	16-21
14664816-6	2003	The response to FGF-2 upregulation was supported by our finding that FGF receptor-1 (FGFR-1) and heparan sulfate (HS), known to be essential for FGF-2 signaling, were expressed by adult rat RGCs.	Heparitin Sulfate	97-112	fibroblast growth factor 2	Rattus norvegicus	145-150
14664816-6	2003	The response to FGF-2 upregulation was supported by our finding that FGF receptor-1 (FGFR-1) and heparan sulfate (HS), known to be essential for FGF-2 signaling, were expressed by adult rat RGCs.	Heparitin Sulfate	114-116	fibroblast growth factor 2	Rattus norvegicus	16-21
14664816-6	2003	The response to FGF-2 upregulation was supported by our finding that FGF receptor-1 (FGFR-1) and heparan sulfate (HS), known to be essential for FGF-2 signaling, were expressed by adult rat RGCs.	Heparitin Sulfate	114-116	fibroblast growth factor 2	Rattus norvegicus	145-150
12907685-1	2003	Heparan, the common unsulfated precursor of heparan sulfate (HS) and heparin, is synthesized on the glycosaminoglycan-protein linkage region tetrasaccharide GlcUA-Gal-Gal-Xyl attached to the respective core proteins presumably by HS co-polymerases encoded by EXT1 and EXT2, the genetic defects of which result in hereditary multiple exostoses in humans.	Heparitin Sulfate	61-63	exostosin glycosyltransferase 2	Homo sapiens	268-272
12912996-5	2003	Heparan sulfate and dextran sulfate also enhanced the BMP-2 activity, although the chemically desulfated heparin-derivatives have lost this stimulatory capacity.	Heparitin Sulfate	0-15	bone morphogenetic protein 2	Homo sapiens	54-59
12907685-0	2003	In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction.	Heparitin Sulfate	9-24	exostosin glycosyltransferase 1	Homo sapiens	120-124
12907685-0	2003	In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction.	Heparitin Sulfate	9-24	exostosin glycosyltransferase 2	Homo sapiens	125-129
12907685-1	2003	Heparan, the common unsulfated precursor of heparan sulfate (HS) and heparin, is synthesized on the glycosaminoglycan-protein linkage region tetrasaccharide GlcUA-Gal-Gal-Xyl attached to the respective core proteins presumably by HS co-polymerases encoded by EXT1 and EXT2, the genetic defects of which result in hereditary multiple exostoses in humans.	Heparitin Sulfate	61-63	exostosin glycosyltransferase 1	Homo sapiens	259-263
12732629-4	2003	RGD-independent cell adhesion to tTG-FN does not require transamidating activity, is mediated by the binding of tTG to cell-surface heparan sulfate chains, is dependent on the function of protein kinase Calpha, and leads to activation of the cell survival focal adhesion kinase.	Heparitin Sulfate	132-147	transglutaminase 2, C polypeptide	Mus musculus	112-115
14502551-9	2003	In addition, FGF7 and homologues may be useful in pharmaceutical neutralization of anticoagulant heparin and heparan sulfate.	Heparitin Sulfate	109-124	fibroblast growth factor 7	Homo sapiens	13-17
14530380-0	2003	Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer"s beta-secretase.	Heparitin Sulfate	0-15	amyloid beta precursor protein	Homo sapiens	26-51
14530380-0	2003	Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer"s beta-secretase.	Heparitin Sulfate	0-15	beta-secretase 1	Homo sapiens	66-71
14530380-2	2003	Here we report evidence that heparan sulfate (HS) interacts with beta-site APP-cleaving enzyme (BACE) 1 and regulates its cleavage of APP.	Heparitin Sulfate	29-44	beta-secretase 1	Homo sapiens	65-103
14530380-2	2003	Here we report evidence that heparan sulfate (HS) interacts with beta-site APP-cleaving enzyme (BACE) 1 and regulates its cleavage of APP.	Heparitin Sulfate	46-48	beta-secretase 1	Homo sapiens	65-103
14530380-3	2003	We show that HS and heparin interact directly with BACE1 and inhibit in vitro processing of peptide and APP substrates.	Heparitin Sulfate	13-15	beta-secretase 1	Homo sapiens	51-56
14530380-6	2003	Endogenous HS immunoprecipitates with BACE1 and colocalizes with BACE1 in the Golgi complex and at the cell surface, two of its putative sites of action.	Heparitin Sulfate	11-13	beta-secretase 1	Homo sapiens	38-43
14530380-6	2003	Endogenous HS immunoprecipitates with BACE1 and colocalizes with BACE1 in the Golgi complex and at the cell surface, two of its putative sites of action.	Heparitin Sulfate	11-13	beta-secretase 1	Homo sapiens	65-70
12812520-0	2003	Binding of endostatin to endothelial heparan sulphate shows a differential requirement for specific sulphates.	Heparitin Sulfate	37-53	collagen type XVIII alpha 1 chain	Homo sapiens	11-21
14505356-4	2003	Moreover, using heparan sulfate proteoglycan (HSPG)-deficient myeloid cells and porcine aortic endothelial cells (PAECs) expressing chimeric FGFR1, we show that antagonism of FGFR1-mediated DNA synthesis and MAPK activation by SPARC does not require the presence of cell-surface, low-affinity FGF-2 receptors, but can be mediated by an intracellular mechanism that is independent of an interaction with the extracellular ligand-binding domain of FGFR1.	Heparitin Sulfate	16-31	syndecan 2	Homo sapiens	46-50
14505356-4	2003	Moreover, using heparan sulfate proteoglycan (HSPG)-deficient myeloid cells and porcine aortic endothelial cells (PAECs) expressing chimeric FGFR1, we show that antagonism of FGFR1-mediated DNA synthesis and MAPK activation by SPARC does not require the presence of cell-surface, low-affinity FGF-2 receptors, but can be mediated by an intracellular mechanism that is independent of an interaction with the extracellular ligand-binding domain of FGFR1.	Heparitin Sulfate	16-31	fibroblast growth factor receptor 1	Homo sapiens	175-180
14505356-4	2003	Moreover, using heparan sulfate proteoglycan (HSPG)-deficient myeloid cells and porcine aortic endothelial cells (PAECs) expressing chimeric FGFR1, we show that antagonism of FGFR1-mediated DNA synthesis and MAPK activation by SPARC does not require the presence of cell-surface, low-affinity FGF-2 receptors, but can be mediated by an intracellular mechanism that is independent of an interaction with the extracellular ligand-binding domain of FGFR1.	Heparitin Sulfate	16-31	fibroblast growth factor receptor 1	Homo sapiens	175-180
14502551-4	2003	A rare and highly specific motif within a single heparan sulfate chain has been proposed to tether both FGF and the FGFR ectodomain together.	Heparitin Sulfate	49-64	fibroblast growth factor 1	Homo sapiens	104-107
14502551-5	2003	The diversity of heparin-binding motifs within the large FGF family of polypeptides and receptors provides a repertoire of diverse templates for capture of diverse heparin/heparan sulfate motifs in biology.	Heparitin Sulfate	172-187	fibroblast growth factor 1	Homo sapiens	57-60
12867435-0	2003	Crystal structures of the heparan sulfate-binding domain of follistatin.	Heparitin Sulfate	26-41	follistatin	Homo sapiens	60-71
12867435-3	2003	Although an interaction between heparan sulfate chains present at the cell surface and follistatin has been recorded, the impact of this binding reaction on the follistatin-mediated inhibition of transforming growth factor-beta-like signaling remains unclear.	Heparitin Sulfate	32-47	follistatin	Homo sapiens	87-98
12867435-4	2003	To gain a structural insight into this interaction, we have solved the crystal structure of the presumed heparan sulfate-binding domain of follistatin, both alone and in complex with the small heparin analogs sucrose octasulfate and D-myo-inositol hexasulfate.	Heparitin Sulfate	105-120	follistatin	Homo sapiens	139-150
12867435-7	2003	Moreover, the crystallographic analysis of the two protein-ligand complexes mentioned above leads us to propose a potential location for the heparan sulfate-binding site on the surface of follistatin and to suggest the involvement of residues Asn80 and Arg86 in such a follistatin-heparin interaction.	Heparitin Sulfate	141-156	follistatin	Homo sapiens	188-199
12867435-7	2003	Moreover, the crystallographic analysis of the two protein-ligand complexes mentioned above leads us to propose a potential location for the heparan sulfate-binding site on the surface of follistatin and to suggest the involvement of residues Asn80 and Arg86 in such a follistatin-heparin interaction.	Heparitin Sulfate	141-156	follistatin	Homo sapiens	269-280
12818887-0	2003	Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching.	Heparitin Sulfate	0-16	fibroblast growth factor 10	Homo sapiens	63-68
12818887-5	2003	Here we use an immunohistochemistry-based binding assay to show that O-sulfated heparan sulfates (HS) are critical for Fgf10 binding to the distal epithelium.	Heparitin Sulfate	80-96	fibroblast growth factor 10	Homo sapiens	119-124
12818887-5	2003	Here we use an immunohistochemistry-based binding assay to show that O-sulfated heparan sulfates (HS) are critical for Fgf10 binding to the distal epithelium.	Heparitin Sulfate	98-100	fibroblast growth factor 10	Homo sapiens	119-124
14527517-6	2003	Recombinant alpha-1 giardin displayed a Ca(2+)-dependent binding to glycosaminoglycans (GAGs), in particular heparan sulphate, a common GAG in the intestinal tract.	Heparitin Sulfate	109-125	adrenoceptor alpha 1D	Homo sapiens	12-19
12929127-7	2003	Inhibition of syndecan-3 release significantly enhanced Schwann cell adhesion and process extension on dishes coated with the non-collagenous N-terminal domain of alpha4(V) collagen, which binds syndecan-3 and mediates heparan sulfate-dependent Schwann cell adhesion.	Heparitin Sulfate	219-234	syndecan 3	Rattus norvegicus	14-24
14708939-0	2003	Structural determinants of heparan sulphate modulation of GDNF signalling.	Heparitin Sulfate	27-43	glial cell derived neurotrophic factor	Homo sapiens	58-62
12851410-6	2003	Endostatin treatment induced recruitment of alpha5beta1 integrin into the raft fraction via a heparan sulfate proteoglycan-dependent mechanism.	Heparitin Sulfate	94-109	collagen type XVIII alpha 1 chain	Homo sapiens	0-10
12851410-7	2003	Subsequently, through alpha5beta1 integrin, heparan sulfate, and lipid raft-mediated interactions, endostatin induced Src-dependent activation of p190RhoGAP with concomitant decrease in RhoA activity and disassembly of actin stress fibers and focal adhesions.	Heparitin Sulfate	44-59	collagen type XVIII alpha 1 chain	Homo sapiens	99-109
12927798-0	2003	Heparan sulfate is required for bone morphogenetic protein-7 signaling.	Heparitin Sulfate	0-15	bone morphogenetic protein 7	Rattus norvegicus	32-60
12927798-3	2003	We show that HS and heparin chains specifically bind to BMP-7.	Heparitin Sulfate	13-15	bone morphogenetic protein 7	Rattus norvegicus	56-61
12927802-1	2003	Heparanase is an endo-beta-D-glucuronidase involved in cleavage of heparan sulfate residues and hence participates in extracellular matrix degradation and remodeling.	Heparitin Sulfate	67-82	glucuronidase beta	Homo sapiens	22-42
12876215-2	2003	The extent and distribution of sulphate substitution on HS plays a vital role in regulation of the binding of a range of proteins, including IFN-gamma, several interleukins and most chemokines.	Heparitin Sulfate	56-58	interferon gamma	Homo sapiens	141-150
12928380-8	2003	Hence, efficient binding of a murine pre-BCR to stroma cells requires the unique tail of lambda5 and stroma cell-associated heparan sulfate.	Heparitin Sulfate	124-139	BCR activator of RhoGEF and GTPase	Mus musculus	41-44
12928380-9	2003	These findings not only identified heparan sulfate as potential pre-BCR ligands, but will also facilitate the development of appropriate animal models to determine whether a pre-BCR/heparan sulfate interaction is involved in early B cell maturation.	Heparitin Sulfate	35-50	BCR activator of RhoGEF and GTPase	Mus musculus	68-71
12955467-7	2003	In addition to the association with chemokines, heparan sulfate binds cytokines such as IFN-gamma and IL-2.	Heparitin Sulfate	48-63	interferon gamma	Homo sapiens	88-97
12955467-7	2003	In addition to the association with chemokines, heparan sulfate binds cytokines such as IFN-gamma and IL-2.	Heparitin Sulfate	48-63	interleukin 2	Homo sapiens	102-106
12955467-8	2003	In the spleen, heparan sulfate localizes IL-2 to the marginal zone, red pulp, and interdigitating dendritic cells of the T cell zone.	Heparitin Sulfate	15-30	interleukin 2	Homo sapiens	41-45
12955467-9	2003	Our laboratory recently determined that the contribution of heparan sulfate-bound IL-2 to immune responses is substantial, finding that bound, rather than free, IL-2 drives immune responses.	Heparitin Sulfate	60-75	interleukin 2	Homo sapiens	82-86
12951019-6	2003	Infection with neuraminidase-treated virus remained heparan-sulfate-dependent, indicating that a novel attachment mechanism is not revealed by SA removal.	Heparitin Sulfate	52-67	neuraminidase 1	Homo sapiens	15-28
12902511-4	2003	In endothelial culture supernatants, IL-8 was detected in a trimolecular complex with heparan sulfate and syndecan-1.	Heparitin Sulfate	86-101	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
12886459-5	2003	On the other hand, heparin, heparan sulfate, and bovine and tuna dermatan sulfate improved (1.2 to 3.4 times) kallikrein inhibition by antithrombin (1.4 microM), while chondroitin 4- and 6-sulfates reduced it (1.3 times).	Heparitin Sulfate	28-43	serpin family C member 1	Homo sapiens	135-147
12879463-1	2003	BACKGROUND: Syndecan-1 is a transmembrane heparan sulphate proteoglycan that is involved in cell-cell adhesion, organization of cell-matrix adhesion, and regulation of growth factor signaling.	Heparitin Sulfate	42-58	syndecan 1	Homo sapiens	12-22
12788935-0	2003	Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality.	Heparitin Sulfate	72-87	glucuronyl C5-epimerase	Mus musculus	32-55
12886459-4	2003	Almost all available glycosaminoglycans (heparin, heparan sulfate, bovine and tuna dermatan sulfate, chondroitin 4- and 6-sulfates) reduced (1.2 to 3.0 times) the catalytic efficiency of kallikrein (in a nanomolar range) on the hydrolysis of plasminogen (0.3 to 1.8 microM) and increased (1.9 to 7.7 times) the enzyme efficiency in factor XII (0.1 to 10 microM) activation.	Heparitin Sulfate	50-65	kallikrein related peptidase 4	Homo sapiens	187-197
12886459-5	2003	On the other hand, heparin, heparan sulfate, and bovine and tuna dermatan sulfate improved (1.2 to 3.4 times) kallikrein inhibition by antithrombin (1.4 microM), while chondroitin 4- and 6-sulfates reduced it (1.3 times).	Heparitin Sulfate	28-43	kallikrein related peptidase 4	Homo sapiens	110-120
12919102-1	2003	HIP is a heparin/heparan sulfate (Hp/HS) binding protein identical to ribosomal protein L29 that displays diverse biological functions.	Heparitin Sulfate	17-32	predicted gene 13841	Mus musculus	70-91
12873445-7	2003	Heparan sulfate was found in the neuroblastic layer (NBL) at P1, in both nuclear layers from P5 onwards and in the ganglion cell layer (GCL) at all stages.	Heparitin Sulfate	0-15	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	136-139
12811819-3	2003	An immunofluorescence study showed that CTGF/Hcs24 was colocalized with heparan sulfate and perlecan in human chondrosarcoma-derived chondrocytic cell line HCS-2/8 in vitro.	Heparitin Sulfate	72-87	cellular communication network factor 2	Homo sapiens	40-44
12960955-1	2003	The functional pool of lipoprotein lipase (LPL) is anchored to heparan sulfate at the vascular endothelium.	Heparitin Sulfate	63-78	lipoprotein lipase	Homo sapiens	23-41
12811819-3	2003	An immunofluorescence study showed that CTGF/Hcs24 was colocalized with heparan sulfate and perlecan in human chondrosarcoma-derived chondrocytic cell line HCS-2/8 in vitro.	Heparitin Sulfate	72-87	cellular communication network factor 2	Homo sapiens	45-50
12811819-7	2003	Furthermore, CTGF/Hcs24-stimulated gene expression of the aggrecan gene, as well as DNA/proteoglycan synthesis, was diminished when HCS-2/8 cells were pretreated with heparinase, indicating that the effects of CTGF/Hcs24 on chondrocytes occurred through the interaction between CTGF/Hcs24 and heparan sulfate on the cells.	Heparitin Sulfate	293-308	cellular communication network factor 2	Homo sapiens	13-17
12811819-7	2003	Furthermore, CTGF/Hcs24-stimulated gene expression of the aggrecan gene, as well as DNA/proteoglycan synthesis, was diminished when HCS-2/8 cells were pretreated with heparinase, indicating that the effects of CTGF/Hcs24 on chondrocytes occurred through the interaction between CTGF/Hcs24 and heparan sulfate on the cells.	Heparitin Sulfate	293-308	cellular communication network factor 2	Homo sapiens	18-23
12960955-1	2003	The functional pool of lipoprotein lipase (LPL) is anchored to heparan sulfate at the vascular endothelium.	Heparitin Sulfate	63-78	lipoprotein lipase	Homo sapiens	43-46
12857926-5	2003	Our experiments indicate that this inhibition resulted from binding of heparan sulfate by OPG.	Heparitin Sulfate	71-86	TNF receptor superfamily member 11b	Homo sapiens	90-93
12878436-4	2003	Heparan sulphate proteoglycans may promote amyloid-beta peptide (Abeta) or tau fibrillisation on the one hand, and provide resistance against proteolytic breakdown on the other.	Heparitin Sulfate	0-16	microtubule associated protein tau	Homo sapiens	75-78
12740361-7	2003	Recombinant 3-OST-5 only exhibited sulfotransferase activity toward heparan sulfate and heparin.	Heparitin Sulfate	68-83	heparan sulfate-glucosamine 3-sulfotransferase 5	Homo sapiens	12-19
12918105-7	2003	Heparanase activity was defined as the ability to degrade high molecular weight (40-100 kDa) radiolabeled HS (heparan sulfate) substrate into low molecular weight (5-15 kDa) HS fragments that could be differentiated by gel filtration chromatography.	Heparitin Sulfate	110-125	heparanase	Homo sapiens	0-10
12713442-1	2003	The mammalian endoglycosidase heparanase (Hpa1) is primarily responsible for cleaving heparan sulphate proteoglycans (HSPGs) present on the basement membrane of cells and its potential for remodelling the extracellular matrix (ECM) could be important in embryonic development and tumour metastasis.	Heparitin Sulfate	86-102	heparanase	Homo sapiens	30-40
12713442-1	2003	The mammalian endoglycosidase heparanase (Hpa1) is primarily responsible for cleaving heparan sulphate proteoglycans (HSPGs) present on the basement membrane of cells and its potential for remodelling the extracellular matrix (ECM) could be important in embryonic development and tumour metastasis.	Heparitin Sulfate	86-102	heparanase	Homo sapiens	42-46
12702549-6	2003	Both dissociative density gradient ultracentrifugation and heparin displacement revealed that elastase dissociated from heparan sulfate/syndecan-1 was fully inhibited by the endogenous antielastases.	Heparitin Sulfate	120-135	syndecan 1	Homo sapiens	136-146
12672474-0	2003	Interaction of platelet factor 4 with fibroblast growth factor 2 is stabilised by heparan sulphate.	Heparitin Sulfate	82-98	fibroblast growth factor 2	Homo sapiens	38-64
12702549-9	2003	Taken together, the results bring a new focus to heparan sulfate/syndecan-1 complexed with neutrophil elastase in inflamed bronchial secretions as a target for modulating elastase susceptibility to physiological antielastases.	Heparitin Sulfate	49-64	syndecan 1	Homo sapiens	65-75
12702549-9	2003	Taken together, the results bring a new focus to heparan sulfate/syndecan-1 complexed with neutrophil elastase in inflamed bronchial secretions as a target for modulating elastase susceptibility to physiological antielastases.	Heparitin Sulfate	49-64	elastase, neutrophil expressed	Homo sapiens	91-110
12964742-1	2003	A new method using a combination of electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MSn) was developed for the identification and quantitative analysis of eight heparan sulfate (HS)- and heparin-derived delta-disaccharides obtained by enzymatic depolymerization.	Heparitin Sulfate	194-209	moesin	Bos taurus	117-120
12964742-1	2003	A new method using a combination of electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MSn) was developed for the identification and quantitative analysis of eight heparan sulfate (HS)- and heparin-derived delta-disaccharides obtained by enzymatic depolymerization.	Heparitin Sulfate	211-213	moesin	Bos taurus	117-120
12672474-2	2003	We investigated the heparan sulphate-dependent mechanism of PF4 inhibition of fibroblast growth factor 2 (FGF-2).	Heparitin Sulfate	20-36	platelet factor 4	Homo sapiens	60-63
12672474-2	2003	We investigated the heparan sulphate-dependent mechanism of PF4 inhibition of fibroblast growth factor 2 (FGF-2).	Heparitin Sulfate	20-36	fibroblast growth factor 2	Homo sapiens	78-104
12672474-2	2003	We investigated the heparan sulphate-dependent mechanism of PF4 inhibition of fibroblast growth factor 2 (FGF-2).	Heparitin Sulfate	20-36	fibroblast growth factor 2	Homo sapiens	106-111
12773484-1	2003	Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate and is implicated in diverse physiological and pathological processes.	Heparitin Sulfate	56-71	glucuronidase beta	Homo sapiens	22-42
12543640-1	2003	Syndecan-4 is one of the principal heparan sulfate-carrying proteins on the cell surface.	Heparitin Sulfate	35-50	syndecan 4	Mus musculus	0-10
12860282-5	2003	Endostatin binds to a specific motif in heparan sulfate, which may serve a co-receptor function.	Heparitin Sulfate	40-55	collagen, type XVIII, alpha 1	Mus musculus	0-10
12736188-1	2003	External surfaces of cells are normally protected by extracellular superoxide dismutase, SOD3, which binds to polyanions such as heparan sulfate.	Heparitin Sulfate	129-144	superoxide dismutase 3	Rattus norvegicus	89-93
12761845-3	2003	Accumulating evidence demonstrates that signalling of these molecules requires the presence of heparan sulfate chains attached to a proteoglycan core protein (HSPG).	Heparitin Sulfate	95-110	decorin	Homo sapiens	132-157
12761845-3	2003	Accumulating evidence demonstrates that signalling of these molecules requires the presence of heparan sulfate chains attached to a proteoglycan core protein (HSPG).	Heparitin Sulfate	95-110	syndecan 2	Homo sapiens	159-163
12761845-9	2003	We find that FGF2 stimulation of proliferation is inhibited in the presence of sodium chlorate, an inhibitor of heparan sulfate synthesis, and is rescued by addition of exogenous heparan sulfate.	Heparitin Sulfate	112-127	fibroblast growth factor 2	Homo sapiens	13-17
12761845-9	2003	We find that FGF2 stimulation of proliferation is inhibited in the presence of sodium chlorate, an inhibitor of heparan sulfate synthesis, and is rescued by addition of exogenous heparan sulfate.	Heparitin Sulfate	179-194	fibroblast growth factor 2	Homo sapiens	13-17
12761845-10	2003	These data support a requirement for heparan sulfate in FGF signalling for proliferation of brain precursor cells.	Heparitin Sulfate	37-52	fibroblast growth factor 2	Homo sapiens	56-59
12759423-0	2003	Propagation and control of T cell responses by heparan sulfate-bound IL-2.	Heparitin Sulfate	47-62	interleukin 2	Homo sapiens	69-73
12626395-0	2003	The binding of human glial cell line-derived neurotrophic factor to heparin and heparan sulfate: importance of 2-O-sulfate groups and effect on its interaction with its receptor, GFRalpha1.	Heparitin Sulfate	80-95	glial cell derived neurotrophic factor	Homo sapiens	21-64
12626395-4	2003	Highly sulfated heparan sulfate is also an effective competitor for GDNF binding.	Heparitin Sulfate	16-31	glial cell derived neurotrophic factor	Homo sapiens	68-72
12692154-4	2003	Here, we report on the effects of NDST deficiency on Ca2+ kinetics in myotubes from NDST-1- and NDST-2-deficient mice, indicating a novel role for heparan sulfate in skeletal muscle physiology.	Heparitin Sulfate	147-162	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	96-102
12692154-5	2003	Immunostaining for specific heparan sulfate epitopes showed major changes in the heparan sulfate composition in skeletal muscle tissue derived from NDST-1-/- mice and NDST-/- cultured myotubes.	Heparitin Sulfate	28-43	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	148-154
12759423-4	2003	In this study, we show that the most salient properties of IL-2, propagation and control of T cell responses, are mediated in vivo by bound and not free cytokine and specifically by heparan sulfate-bound IL-2.	Heparitin Sulfate	182-197	interleukin 2	Homo sapiens	59-63
12759423-4	2003	In this study, we show that the most salient properties of IL-2, propagation and control of T cell responses, are mediated in vivo by bound and not free cytokine and specifically by heparan sulfate-bound IL-2.	Heparitin Sulfate	182-197	interleukin 2	Homo sapiens	204-208
12801641-1	2003	Sulphamidase is a lysosomal enzyme necessary for the degradation of heparan sulphate.	Heparitin Sulfate	68-84	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	0-12
12826233-2	2003	In addition to its complement inhibiting abilities, VCP can bind heparan sulfate on cell surfaces, resulting in further functional activities.	Heparitin Sulfate	65-80	valosin containing protein	Homo sapiens	52-55
12591930-5	2003	Here we show that all brain endothelial cell HSPGs carry heparan sulfate chains similarly capable of forming a ternary complex with FGF2 and fibroblast growth factor receptor-1c and of promoting a mitogenic signal.	Heparitin Sulfate	57-72	fibroblast growth factor 2	Homo sapiens	132-136
12604602-0	2003	The involvement of heparan sulfate (HS) in FGF1/HS/FGFR1 signaling complex.	Heparitin Sulfate	19-34	fibroblast growth factor 1	Mus musculus	43-47
12604602-0	2003	The involvement of heparan sulfate (HS) in FGF1/HS/FGFR1 signaling complex.	Heparitin Sulfate	19-34	fibroblast growth factor receptor 1	Mus musculus	51-56
12604602-0	2003	The involvement of heparan sulfate (HS) in FGF1/HS/FGFR1 signaling complex.	Heparitin Sulfate	36-38	fibroblast growth factor 1	Mus musculus	43-47
12604602-0	2003	The involvement of heparan sulfate (HS) in FGF1/HS/FGFR1 signaling complex.	Heparitin Sulfate	36-38	fibroblast growth factor receptor 1	Mus musculus	51-56
12604602-7	2003	The ability of HS to support the ternary complex formation was found to be required for FGF1-stimulated cell proliferation.	Heparitin Sulfate	15-17	fibroblast growth factor 1	Mus musculus	88-92
12731055-7	2003	Heparan sulfate and dermatan sulfate, but not chondroitin sulfate, also inhibited the actions of CCL11 and CCL13 in assays of cellular shape change and chemotaxis.	Heparitin Sulfate	0-15	C-C motif chemokine ligand 11	Homo sapiens	97-102
12690039-10	2003	Optical biosensor studies revealed that PI-88 potently inhibited (Ki 10.3 nmol/L) the interaction of FGF-2 with heparan sulfate.	Heparitin Sulfate	112-127	fibroblast growth factor 2	Rattus norvegicus	101-106
12731055-7	2003	Heparan sulfate and dermatan sulfate, but not chondroitin sulfate, also inhibited the actions of CCL11 and CCL13 in assays of cellular shape change and chemotaxis.	Heparitin Sulfate	0-15	C-C motif chemokine ligand 13	Homo sapiens	107-112
12752450-3	2003	Hence, S. pyogenes strains expressing a large number of different types of M proteins bound to dermatan sulfate (DS), highly sulfated fractions of heparan sulfate (HS) and heparin, whereas strains deficient in M protein surface expression failed to interact with these GAGs.	Heparitin Sulfate	147-162	myomesin 2	Homo sapiens	75-84
12591924-9	2003	The unusually severe thrombosis associated with the heterozygous mutation may be explained by the ability of antithrombin London to bind endogenous heparan sulfate or heparin molecules with high affinity and to thereby block activation of the normal inhibitor.	Heparitin Sulfate	148-163	serpin family C member 1	Homo sapiens	109-121
12752450-7	2003	Together with the finding that exogenous DS and HS could inhibit streptococcal adhesion, these data suggest that GAGs function as receptors in M protein-mediated adhesion of S. pyogenes.	Heparitin Sulfate	48-50	myomesin 2	Homo sapiens	143-152
12684756-2	2003	Normal human colonic and small intestinal enterocytes, and cultured HT-29 (but not Caco-2) enterocytes, reacted prominently with antibodies specific for heparan sulfate and for the core protein of syndecan-1 (a heparan sulfate proteoglycan).	Heparitin Sulfate	211-226	syndecan 1	Homo sapiens	197-207
12684756-9	2003	Thus, heparan sulfate (possibly as the heparan sulfate proteoglycan syndecan-1) appears to participate in interactions of L. monocytogenes with enterocytes.	Heparitin Sulfate	6-21	syndecan 1	Homo sapiens	68-78
12895655-3	2003	Chemotaxis toward calcitonin gene-related peptide, secretoneurin, vasoactive intestinal peptide (VIP), and substance P (SP) was abolished by removal of heparan sulfate side chains from cell surface proteoglycans or by addition of anti-syndecan-4 antibodies.	Heparitin Sulfate	152-167	secretogranin II	Homo sapiens	51-64
12895655-3	2003	Chemotaxis toward calcitonin gene-related peptide, secretoneurin, vasoactive intestinal peptide (VIP), and substance P (SP) was abolished by removal of heparan sulfate side chains from cell surface proteoglycans or by addition of anti-syndecan-4 antibodies.	Heparitin Sulfate	152-167	vasoactive intestinal peptide	Homo sapiens	66-95
12895655-3	2003	Chemotaxis toward calcitonin gene-related peptide, secretoneurin, vasoactive intestinal peptide (VIP), and substance P (SP) was abolished by removal of heparan sulfate side chains from cell surface proteoglycans or by addition of anti-syndecan-4 antibodies.	Heparitin Sulfate	152-167	vasoactive intestinal peptide	Homo sapiens	97-100
12895655-3	2003	Chemotaxis toward calcitonin gene-related peptide, secretoneurin, vasoactive intestinal peptide (VIP), and substance P (SP) was abolished by removal of heparan sulfate side chains from cell surface proteoglycans or by addition of anti-syndecan-4 antibodies.	Heparitin Sulfate	152-167	tachykinin precursor 1	Homo sapiens	107-118
12895655-3	2003	Chemotaxis toward calcitonin gene-related peptide, secretoneurin, vasoactive intestinal peptide (VIP), and substance P (SP) was abolished by removal of heparan sulfate side chains from cell surface proteoglycans or by addition of anti-syndecan-4 antibodies.	Heparitin Sulfate	152-167	tachykinin precursor 1	Homo sapiens	120-122
12895655-3	2003	Chemotaxis toward calcitonin gene-related peptide, secretoneurin, vasoactive intestinal peptide (VIP), and substance P (SP) was abolished by removal of heparan sulfate side chains from cell surface proteoglycans or by addition of anti-syndecan-4 antibodies.	Heparitin Sulfate	152-167	syndecan 4	Homo sapiens	235-245
12551932-9	2003	Tat neurotoxicity was attenuated by anti-Tat antibodies, kynurenate or heparan sulfate.	Heparitin Sulfate	71-86	tyrosine aminotransferase	Rattus norvegicus	0-3
12562774-0	2003	Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis.	Heparitin Sulfate	124-139	exostosin like glycosyltransferase 2	Homo sapiens	66-71
12647303-10	2003	Furthermore, pre-treatment with heparinase III decreased nuclear FGF-2, and CHO cells defective in the ability to properly synthesize heparan sulfate chains showed reduced nuclear FGF-2 indicating that the heparan sulfate chains of HSPG are critical for this process.	Heparitin Sulfate	134-149	fibroblast growth factor 2	Cricetulus griseus	180-185
12647303-10	2003	Furthermore, pre-treatment with heparinase III decreased nuclear FGF-2, and CHO cells defective in the ability to properly synthesize heparan sulfate chains showed reduced nuclear FGF-2 indicating that the heparan sulfate chains of HSPG are critical for this process.	Heparitin Sulfate	134-149	LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein	Cricetulus griseus	232-236
12647303-10	2003	Furthermore, pre-treatment with heparinase III decreased nuclear FGF-2, and CHO cells defective in the ability to properly synthesize heparan sulfate chains showed reduced nuclear FGF-2 indicating that the heparan sulfate chains of HSPG are critical for this process.	Heparitin Sulfate	206-221	fibroblast growth factor 2	Cricetulus griseus	180-185
12647303-10	2003	Furthermore, pre-treatment with heparinase III decreased nuclear FGF-2, and CHO cells defective in the ability to properly synthesize heparan sulfate chains showed reduced nuclear FGF-2 indicating that the heparan sulfate chains of HSPG are critical for this process.	Heparitin Sulfate	206-221	LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein	Cricetulus griseus	232-236
12566461-0	2003	Heparan sulfate regulates targeting of syndecan-1 to a functional domain on the cell surface.	Heparitin Sulfate	0-15	syndecan 1	Homo sapiens	39-49
12566461-3	2003	The present study reveals the surprising finding that targeting of syndecan-1 to uropods is mediated by its heparan sulfate chains and that targeting is regulated by cell surface events rather than solely by intracellular mechanisms.	Heparitin Sulfate	108-123	syndecan 1	Homo sapiens	67-77
12566461-5	2003	Interestingly, the heparan sulfate-bearing proteoglycans glypican-1 and beta glycan fail to concentrate in uropods, indicating that targeting may require heparan sulfate structural motifs unique to syndecan-1 or that the core protein of syndecan-1 participates in specific interactions that promote heparan sulfate-mediated targeting.	Heparitin Sulfate	19-34	glypican 1	Homo sapiens	57-67
12566461-6	2003	These findings suggest functional specificity for syndecan-1 within uropods and, in addition, reveal a novel mechanism for the targeting of molecules to discrete membrane subcellular domains via heparan sulfate.	Heparitin Sulfate	195-210	syndecan 1	Homo sapiens	50-60
12571251-0	2003	Syndecan-1 and -4 synthesized simultaneously by mouse mammary gland epithelial cells bear heparan sulfate chains that are apparently structurally indistinguishable.	Heparitin Sulfate	90-105	syndecan 1	Mus musculus	0-17
12571251-4	2003	In this paper we demonstrate that the HS chains on affinity-purified syndecan-1 and -4 from murine mammary gland cells are essentially identical by a number of parameters.	Heparitin Sulfate	38-40	syndecan 1	Mus musculus	69-86
12691827-1	2003	Heparanase is an endo-beta-D-glucuronidase that can cleave heparan sulfate and has been implicated in tumor angiogenesis and metastasis.	Heparitin Sulfate	59-74	heparanase	Homo sapiens	0-10
12691827-1	2003	Heparanase is an endo-beta-D-glucuronidase that can cleave heparan sulfate and has been implicated in tumor angiogenesis and metastasis.	Heparitin Sulfate	59-74	glucuronidase beta	Homo sapiens	22-42
12584198-9	2003	We conclude that C. elegans SQV-6 and SQV-2 likely act in concert with other SQV proteins to catalyze the stepwise formation of the proteoglycan core protein linkage tetrasaccharide GlcAbeta1,3Galbeta1, 3Galbeta1,4Xylbeta-O-(Ser), which is common to the two major types of glycosaminoglycans in vertebrates, chondroitin and heparan sulfate.	Heparitin Sulfate	324-339	Protein xylosyltransferase;Xylosyltransferase sqv-6	Caenorhabditis elegans	28-33
12584198-9	2003	We conclude that C. elegans SQV-6 and SQV-2 likely act in concert with other SQV proteins to catalyze the stepwise formation of the proteoglycan core protein linkage tetrasaccharide GlcAbeta1,3Galbeta1, 3Galbeta1,4Xylbeta-O-(Ser), which is common to the two major types of glycosaminoglycans in vertebrates, chondroitin and heparan sulfate.	Heparitin Sulfate	324-339	Beta-1,3-galactosyltransferase sqv-2	Caenorhabditis elegans	38-43
12653632-5	2003	It may therefore be proposed that GDNF normally binds to 2-O-sulphate-rich heparan sulphate within kidney progenitor tissues, and that this interaction is essential for its activity in kidney development.	Heparitin Sulfate	75-91	glial cell line derived neurotrophic factor	Mus musculus	34-38
12653636-1	2003	Hepatocyte growth factor (HGF)/scatter factor (SF) is a unique growth factor, in that it binds both heparan sulphate (HS) and dermatan sulphate (DS).	Heparitin Sulfate	100-116	hepatocyte growth factor	Homo sapiens	26-29
12653636-1	2003	Hepatocyte growth factor (HGF)/scatter factor (SF) is a unique growth factor, in that it binds both heparan sulphate (HS) and dermatan sulphate (DS).	Heparitin Sulfate	118-120	hepatocyte growth factor	Homo sapiens	26-29
12670907-2	2003	CD44 isoforms bearing heparin sulfate chains can bind to HGF/SF and facilitate its presentation to c-Met.	Heparitin Sulfate	22-37	CD44 antigen	Mus musculus	0-4
12670907-2	2003	CD44 isoforms bearing heparin sulfate chains can bind to HGF/SF and facilitate its presentation to c-Met.	Heparitin Sulfate	22-37	hepatocyte growth factor	Mus musculus	57-63
12670907-2	2003	CD44 isoforms bearing heparin sulfate chains can bind to HGF/SF and facilitate its presentation to c-Met.	Heparitin Sulfate	22-37	met proto-oncogene	Mus musculus	99-104
12620978-2	2003	Dpp is a heparin-binding protein and Dpp signal transduction is potentiated by Dally, a cell-surface heparan sulfate proteoglycan, during assembly of several adult tissues.	Heparitin Sulfate	101-116	decapentaplegic	Drosophila melanogaster	0-3
12620978-2	2003	Dpp is a heparin-binding protein and Dpp signal transduction is potentiated by Dally, a cell-surface heparan sulfate proteoglycan, during assembly of several adult tissues.	Heparitin Sulfate	101-116	decapentaplegic	Drosophila melanogaster	37-40
12716937-2	2003	MPS VII mice lack lysosomal beta-glucuronidase (GUSB) activity, leading to the accumulation of partially degraded chondroitin, dermatan, and heparan sulfates in most tissues.	Heparitin Sulfate	141-157	glucuronidase, beta	Mus musculus	28-46
12716937-2	2003	MPS VII mice lack lysosomal beta-glucuronidase (GUSB) activity, leading to the accumulation of partially degraded chondroitin, dermatan, and heparan sulfates in most tissues.	Heparitin Sulfate	141-157	glucuronidase, beta	Mus musculus	48-52
12654635-0	2003	Binding of interleukin-8 to heparan sulfate and chondroitin sulfate in lung tissue.	Heparitin Sulfate	28-43	C-X-C motif chemokine ligand 8	Homo sapiens	11-24
12654635-5	2003	Confocal microscopy demonstrated IL-8 binding to specific anatomic locations such as cell surfaces and extracellular matrix that were enriched with heparan sulfate and chondroitin sulfate.	Heparitin Sulfate	148-163	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
12654635-6	2003	Removal of heparan sulfate or chondroitin sulfate from lung tissue significantly decreased the binding of 125I-IL-8.	Heparitin Sulfate	11-26	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
12654300-1	2003	The unc-52 gene of Claenorhabditis elegans encodes a homologue of the basement membrane heparan sulfate proteoglycan perlecan.	Heparitin Sulfate	88-103	Basement membrane proteoglycan;Ig-like domain-containing protein	Caenorhabditis elegans	4-10
12569571-1	2003	Heparanase, a heparan sulfate-specific endo-beta-D-glucuronidase, plays an important role in tumor cell metastasis through the degradation of extracellular matrix heparan sulfate proteoglycans (ECM HSPG).	Heparitin Sulfate	14-29	heparanase	Homo sapiens	0-10
12697740-3	2003	CD44-negative Namalwa cells transfected with CD44vRA cDNA or with CD44v3-v10 (CD44vRA wild type) cDNA bound FGF-2 to an equal extent via their associated heparan sulfate chains.	Heparitin Sulfate	154-169	CD44 molecule (Indian blood group)	Homo sapiens	0-4
12697740-3	2003	CD44-negative Namalwa cells transfected with CD44vRA cDNA or with CD44v3-v10 (CD44vRA wild type) cDNA bound FGF-2 to an equal extent via their associated heparan sulfate chains.	Heparitin Sulfate	154-169	fibroblast growth factor 2	Homo sapiens	108-113
12697740-8	2003	Hence, FGF-2 attached to the heparan sulfate moiety expressed by the novel CD44 variant of RA synovium cells exhibits an augmented ability to stimulate FGFR-1-mediated activities.	Heparitin Sulfate	29-44	fibroblast growth factor 2	Homo sapiens	7-12
12697740-8	2003	Hence, FGF-2 attached to the heparan sulfate moiety expressed by the novel CD44 variant of RA synovium cells exhibits an augmented ability to stimulate FGFR-1-mediated activities.	Heparitin Sulfate	29-44	CD44 molecule (Indian blood group)	Homo sapiens	75-79
12697740-8	2003	Hence, FGF-2 attached to the heparan sulfate moiety expressed by the novel CD44 variant of RA synovium cells exhibits an augmented ability to stimulate FGFR-1-mediated activities.	Heparitin Sulfate	29-44	fibroblast growth factor receptor 1	Homo sapiens	152-158
12799195-2	2003	The ability of VCP to bind heparan sulfate allows the protein to attach itself to the cell surface, enabling it with many additional activities.	Heparitin Sulfate	27-42	valosin containing protein	Homo sapiens	15-18
12799195-4	2003	VCP has recently been shown to inhibit human anti-Gal alpha1-3 Gal antibody attachment to cultured porcine endothelial cells and reduce human neutrophil and NK killing of pig aortic endothelial cells through its ability to bind heparan sulfate.	Heparitin Sulfate	228-243	valosin containing protein	Homo sapiens	0-3
12671048-1	2003	Endothelial cell production of anticoagulant heparan sulfate (HS(act)) is controlled by the Hs3st1 gene, which encodes the rate-limiting enzyme heparan sulfate 3-O-sulfotransferase-1 (3-OST-1).	Heparitin Sulfate	45-60	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	Mus musculus	92-98
12569571-1	2003	Heparanase, a heparan sulfate-specific endo-beta-D-glucuronidase, plays an important role in tumor cell metastasis through the degradation of extracellular matrix heparan sulfate proteoglycans (ECM HSPG).	Heparitin Sulfate	14-29	glucuronidase beta	Homo sapiens	44-64
12644256-4	2003	Among them, two enzymes, EXT1 and EXT2, catalyze polymerization of glucuronic acid and N-acetylglucosamine, the crucial step of HS synthesis.	Heparitin Sulfate	128-130	exostosin glycosyltransferase 1	Mus musculus	25-29
12406885-6	2003	A specific MIP-1alpha-binding HS oligosaccharide preparation of M(r) 10 kDa that optimally supported LTC-IC maintenance was identified.	Heparitin Sulfate	30-32	C-C motif chemokine ligand 3	Homo sapiens	11-21
12644256-4	2003	Among them, two enzymes, EXT1 and EXT2, catalyze polymerization of glucuronic acid and N-acetylglucosamine, the crucial step of HS synthesis.	Heparitin Sulfate	128-130	exostosin glycosyltransferase 2	Mus musculus	34-38
12549928-0	2003	Cell surface heparan sulfate participates in CXCL1-induced signaling.	Heparitin Sulfate	13-28	C-X-C motif chemokine ligand 1	Homo sapiens	45-50
12598330-4	2003	A response was acquired, however, when myofibroblasts were incubated with FGF-2 in the presence of heparan sulfate (HS) and heparin.	Heparitin Sulfate	99-114	fibroblast growth factor 2	Homo sapiens	74-79
12598330-4	2003	A response was acquired, however, when myofibroblasts were incubated with FGF-2 in the presence of heparan sulfate (HS) and heparin.	Heparitin Sulfate	116-118	fibroblast growth factor 2	Homo sapiens	74-79
12606025-1	2003	Some synthetic dextran derivatives that mimic the action of heparin/heparan sulfate were previously shown to inhibit neutrophil elastase and plasmin.	Heparitin Sulfate	68-83	elastase, neutrophil expressed	Homo sapiens	117-136
12606025-1	2003	Some synthetic dextran derivatives that mimic the action of heparin/heparan sulfate were previously shown to inhibit neutrophil elastase and plasmin.	Heparitin Sulfate	68-83	plasminogen	Homo sapiens	141-148
12625842-0	2003	Glycosaminoglycans in human retinoblastoma cells: heparan sulfate, a modulator of the pigment epithelium-derived factor-receptor interactions.	Heparitin Sulfate	50-65	serpin family F member 1	Homo sapiens	86-119
12625842-7	2003	CONCLUSIONS: These data indicate that retinoblastoma cells secrete heparin/heparan sulfate with binding affinity for PEDF, which may be important in efficient cell-surface receptor binding.	Heparitin Sulfate	75-90	serpin family F member 1	Homo sapiens	117-121
12574387-8	2003	Our results indicate that synoviocyte-derived CXCL12 accumulates and it is immobilized on heparan sulfate molecules of endothelial cells, where it can promote angiogenesis and inflammatory cell infiltration, supporting a multifaceted function for this chemokine in the pathogenesis of rheumatoid arthritis.	Heparitin Sulfate	90-105	chemokine (C-X-C motif) ligand 12	Mus musculus	46-52
12584571-3	2003	Another ECM remodeling enzyme is the heparanase (Hpa) that digests the heparin sulfate component of the matrix.	Heparitin Sulfate	71-86	heparanase	Homo sapiens	37-47
12584571-3	2003	Another ECM remodeling enzyme is the heparanase (Hpa) that digests the heparin sulfate component of the matrix.	Heparitin Sulfate	71-86	heparanase	Homo sapiens	49-52
12565862-0	2003	EXT gene family member rib-2 is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans.	Heparitin Sulfate	72-87	Exostosin-2 homolog	Caenorhabditis elegans	23-28
12565862-7	2003	The analysis using fluorometric post-column high-performance liquid chromatography also uncovered reduced production of heparan sulfate in the rib-2 mutant.	Heparitin Sulfate	120-135	Exostosin-2 homolog	Caenorhabditis elegans	143-148
12565862-8	2003	These results indicate that rib-2 is essential for embryonic development and heparan sulfate biosynthesis in C. elegans.	Heparitin Sulfate	77-92	Exostosin-2 homolog	Caenorhabditis elegans	28-33
12600949-9	2003	Heparan sulfate from PXE-affected individuals and healthy carriers produced significantly less N-sulfated disaccharide and more disaccharide sulfated at the C-6 position with no significant abnormality of the nonsulfated disaccharide percentage and sulfates:disaccharide ratio.	Heparitin Sulfate	0-15	complement C6	Homo sapiens	157-160
12590599-0	2003	Distinct effects on heparan sulfate structure by different active site mutations in NDST-1.	Heparitin Sulfate	20-35	N-deacetylase and N-sulfotransferase 1	Homo sapiens	84-90
12590599-4	2003	NDST-1 and -2 have a wide and largely overlapping tissue distribution, but it is not known if they can act on the same heparan sulfate chain.	Heparitin Sulfate	119-134	N-deacetylase and N-sulfotransferase 1	Homo sapiens	0-13
12590599-12	2003	Structural analyses of heparan sulfate synthesized by these cells and by cells overexpressing wild-type NDST-1 demonstrate that the N-deacetylation step is not only prerequisite but also rate-limiting, determining the degree of N-sulfation.	Heparitin Sulfate	23-38	N-deacetylase and N-sulfotransferase 1	Homo sapiens	104-110
12590599-15	2003	In addition, we show that oversulfation of heparan sulfate produced by cells tranfected with wild-type NDST-1 or the mutant lacking N-sulfotranferase activity results in decreased sulfation of chondroitin sulfate.	Heparitin Sulfate	43-58	N-deacetylase and N-sulfotransferase 1	Homo sapiens	103-109
12581643-3	2003	Activation of antithrombin is brought about by a conformational change initiated upon binding heparin or heparan sulphate.	Heparitin Sulfate	105-121	serpin family C member 1	Homo sapiens	14-26
12549928-9	2003	Moreover, CXCL10 can inhibit CXCL1-induced PAK1 and ERK activation as well as the CXCL1-induced chemotaxis through decreasing CXCL1 binding to cell surface heparan sulfate.	Heparitin Sulfate	156-171	C-X-C motif chemokine ligand 10	Homo sapiens	10-16
12549928-9	2003	Moreover, CXCL10 can inhibit CXCL1-induced PAK1 and ERK activation as well as the CXCL1-induced chemotaxis through decreasing CXCL1 binding to cell surface heparan sulfate.	Heparitin Sulfate	156-171	C-X-C motif chemokine ligand 1	Homo sapiens	10-15
12549928-9	2003	Moreover, CXCL10 can inhibit CXCL1-induced PAK1 and ERK activation as well as the CXCL1-induced chemotaxis through decreasing CXCL1 binding to cell surface heparan sulfate.	Heparitin Sulfate	156-171	C-X-C motif chemokine ligand 1	Homo sapiens	29-34
12549928-9	2003	Moreover, CXCL10 can inhibit CXCL1-induced PAK1 and ERK activation as well as the CXCL1-induced chemotaxis through decreasing CXCL1 binding to cell surface heparan sulfate.	Heparitin Sulfate	156-171	C-X-C motif chemokine ligand 1	Homo sapiens	29-34
14522849-3	2003	Identified ligands of PrP(C) mainly belong to the categories of heat-shock proteins, membrane-bound receptors, or heparan sulphates.	Heparitin Sulfate	114-131	prion protein	Mus musculus	22-25
12479862-7	2003	The glypican-1 core protein is S-nitrosylated and nitric oxide released from these sites cleave the HS chains at glucosamine units lacking N-substitution.	Heparitin Sulfate	100-102	glypican 1	Homo sapiens	4-14
12646390-6	2003	Hepatocyte growth factor/scatter factor (HGF/SF) probably binds its receptor as a dimer stabilised by interactions with heparan sulfate, and fibroblast growth factor (FGF) binds its receptor as a dimer cross-linked by heparan sulfate.	Heparitin Sulfate	120-135	hepatocyte growth factor	Homo sapiens	41-47
12559606-4	2003	We have been using extracellular superoxide dismutase (EC-SOD) attached to the heparan sulfate on the endothelial cell surface as a marker of vascular damage.	Heparitin Sulfate	79-94	superoxide dismutase 3	Homo sapiens	19-53
12559606-4	2003	We have been using extracellular superoxide dismutase (EC-SOD) attached to the heparan sulfate on the endothelial cell surface as a marker of vascular damage.	Heparitin Sulfate	79-94	superoxide dismutase 3	Homo sapiens	55-61
12446672-6	2003	Transfection of the CSGalNAcT-1 gene into Chinese hamster ovary cells yielded a change of glycosaminoglycan composition, i.e. the replacement of heparan sulfate on a syndecan-4/fibroblast growth factor-1 chimera protein by chondroitin sulfate, however, transfection of the CSGalNAcT-2 gene did not.	Heparitin Sulfate	145-160	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Cricetulus griseus	20-31
12446672-6	2003	Transfection of the CSGalNAcT-1 gene into Chinese hamster ovary cells yielded a change of glycosaminoglycan composition, i.e. the replacement of heparan sulfate on a syndecan-4/fibroblast growth factor-1 chimera protein by chondroitin sulfate, however, transfection of the CSGalNAcT-2 gene did not.	Heparitin Sulfate	145-160	syndecan-4	Cricetulus griseus	166-176
12583005-2	2003	Although the structural requirements of heparin and heparan sulfate for the high-affinity binding to bFGF have been extensively examined, studies on intact heparin proteoglycans are limited.	Heparitin Sulfate	52-67	fibroblast growth factor 2	Homo sapiens	101-105
12634318-5	2003	Both NDST-1 and -2 N-deacetylate heparan sulfate from human aorta ( approximately 0.6 sulfate groups/disaccharide) with comparable high efficiency, apparent Km values of 0.35 and 0.76 microM (calculation based on [HexA]) being lower (representing a higher affinity) than those for K5 polysaccharide (13.3 and 4.7 microM, respectively).	Heparitin Sulfate	33-48	N-deacetylase and N-sulfotransferase 1	Homo sapiens	5-18
12573255-1	2003	Mucopolysaccharidosis type IIID (MPS IIID; Sanfilippo syndrome type D; MIM 252940) is caused by deficiency of the activity of N-acetylglucosamine-6-sulfatase (GNS), which is normally required for degradation of heparan sulfate.	Heparitin Sulfate	211-226	glucosamine (N-acetyl)-6-sulfatase	Homo sapiens	126-157
12634318-6	2003	Comparison of various HS preparations and the unsulfated K5 polysaccharide as substrates indicate that both NDST-1 and -2 can differentially N-sulfate polysaccharides already modified to some extent by various other enzymes involved in HS/heparin synthesis.	Heparitin Sulfate	22-24	N-deacetylase and N-sulfotransferase 1	Homo sapiens	108-121
12573255-1	2003	Mucopolysaccharidosis type IIID (MPS IIID; Sanfilippo syndrome type D; MIM 252940) is caused by deficiency of the activity of N-acetylglucosamine-6-sulfatase (GNS), which is normally required for degradation of heparan sulfate.	Heparitin Sulfate	211-226	glucosamine (N-acetyl)-6-sulfatase	Homo sapiens	159-162
12634322-1	2003	Midkine (MK), a heparin-binding growth factor, binds strongly to oversulfated structures in chondroitin sulfates (CSs) and heparan sulfate.	Heparitin Sulfate	123-138	midkine	Homo sapiens	0-7
12634322-1	2003	Midkine (MK), a heparin-binding growth factor, binds strongly to oversulfated structures in chondroitin sulfates (CSs) and heparan sulfate.	Heparitin Sulfate	123-138	midkine	Homo sapiens	9-11
12634318-6	2003	Comparison of various HS preparations and the unsulfated K5 polysaccharide as substrates indicate that both NDST-1 and -2 can differentially N-sulfate polysaccharides already modified to some extent by various other enzymes involved in HS/heparin synthesis.	Heparitin Sulfate	236-238	N-deacetylase and N-sulfotransferase 1	Homo sapiens	108-121
12530973-3	2003	This adsorption is mediated by the binding of gp120 to the heparan sulfate chains of syndecan.	Heparitin Sulfate	59-74	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	46-51
12530973-3	2003	This adsorption is mediated by the binding of gp120 to the heparan sulfate chains of syndecan.	Heparitin Sulfate	59-74	syndecan 1	Homo sapiens	85-93
12656349-0	2003	Surface plasmon resonance analysis to evaluate the importance of heparin sulfate groups" binding with human aFGF and bFGF.	Heparitin Sulfate	65-80	fibroblast growth factor 1	Homo sapiens	108-112
14501011-5	2003	The offending BM component is a heparan sulfate (HS) proteoglycan (HSPG), part of which is protein, and the remainder is a specific linear polysaccharide that is the portion responsible for binding and imparting the typical amyloid structure to the amyloid precursor protein/peptide.	Heparitin Sulfate	32-47	syndecan 2	Mus musculus	67-71
14501011-5	2003	The offending BM component is a heparan sulfate (HS) proteoglycan (HSPG), part of which is protein, and the remainder is a specific linear polysaccharide that is the portion responsible for binding and imparting the typical amyloid structure to the amyloid precursor protein/peptide.	Heparitin Sulfate	49-51	syndecan 2	Mus musculus	67-71
12656349-0	2003	Surface plasmon resonance analysis to evaluate the importance of heparin sulfate groups" binding with human aFGF and bFGF.	Heparitin Sulfate	65-80	fibroblast growth factor 2	Homo sapiens	117-121
12237301-3	2002	Here, we demonstrate that these properties of endostatin are primarily mediated by laminin in the basement membrane and heparan sulfates on the cell surface.	Heparitin Sulfate	120-136	collagen type XVIII alpha 1 chain	Homo sapiens	46-56
12417414-3	2002	HS 2-O-sulfotransferase (Hs2st) occupies a critical position in the succession of enzymes responsible for the biosynthesis of HS, catalysing the transfer of sulfate to the C2-position of selected hexuronic acid residues within the nascent HS chain.	Heparitin Sulfate	0-2	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	25-30
12417414-3	2002	HS 2-O-sulfotransferase (Hs2st) occupies a critical position in the succession of enzymes responsible for the biosynthesis of HS, catalysing the transfer of sulfate to the C2-position of selected hexuronic acid residues within the nascent HS chain.	Heparitin Sulfate	126-128	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	0-23
12417414-3	2002	HS 2-O-sulfotransferase (Hs2st) occupies a critical position in the succession of enzymes responsible for the biosynthesis of HS, catalysing the transfer of sulfate to the C2-position of selected hexuronic acid residues within the nascent HS chain.	Heparitin Sulfate	126-128	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	25-30
12417417-1	2002	Hereditary multiple exostoses (HME, OMIM 133700, 133701) results from mutations in EXT1 and EXT2, genes encoding the copolymerase responsible for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	146-161	exostosin glycosyltransferase 1	Homo sapiens	83-87
12417417-1	2002	Hereditary multiple exostoses (HME, OMIM 133700, 133701) results from mutations in EXT1 and EXT2, genes encoding the copolymerase responsible for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	146-161	exostosin glycosyltransferase 2	Homo sapiens	92-96
12417417-1	2002	Hereditary multiple exostoses (HME, OMIM 133700, 133701) results from mutations in EXT1 and EXT2, genes encoding the copolymerase responsible for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	163-165	exostosin glycosyltransferase 1	Homo sapiens	83-87
12417417-1	2002	Hereditary multiple exostoses (HME, OMIM 133700, 133701) results from mutations in EXT1 and EXT2, genes encoding the copolymerase responsible for heparan sulfate (HS) biosynthesis.	Heparitin Sulfate	163-165	exostosin glycosyltransferase 2	Homo sapiens	92-96
12370176-5	2002	Heparin and heparan sulfate, but not dermatan or chondroitin sulfate, effectively compete for PAPP-A surface binding, and because incubation of cells with heparinase abrogated PAPP-A adhesion, binding is probably mediated by a cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	12-27	pappalysin 1	Homo sapiens	94-100
12370176-5	2002	Heparin and heparan sulfate, but not dermatan or chondroitin sulfate, effectively compete for PAPP-A surface binding, and because incubation of cells with heparinase abrogated PAPP-A adhesion, binding is probably mediated by a cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	12-27	pappalysin 1	Homo sapiens	176-182
12370176-11	2002	Interestingly, the proteolytically inactive, disulfide-bound complex of PAPP-A and the proform of eosinophil major basic protein (proMBP), PAPP-A.proMBP, shows only weak surface binding, probably because the adhesion site of PAPP-A is occupied by heparan sulfate, known to be covalently bound to proMBP.	Heparitin Sulfate	247-262	pappalysin 1	Homo sapiens	72-78
12370176-11	2002	Interestingly, the proteolytically inactive, disulfide-bound complex of PAPP-A and the proform of eosinophil major basic protein (proMBP), PAPP-A.proMBP, shows only weak surface binding, probably because the adhesion site of PAPP-A is occupied by heparan sulfate, known to be covalently bound to proMBP.	Heparitin Sulfate	247-262	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	98-128
12370176-11	2002	Interestingly, the proteolytically inactive, disulfide-bound complex of PAPP-A and the proform of eosinophil major basic protein (proMBP), PAPP-A.proMBP, shows only weak surface binding, probably because the adhesion site of PAPP-A is occupied by heparan sulfate, known to be covalently bound to proMBP.	Heparitin Sulfate	247-262	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	130-136
12370176-11	2002	Interestingly, the proteolytically inactive, disulfide-bound complex of PAPP-A and the proform of eosinophil major basic protein (proMBP), PAPP-A.proMBP, shows only weak surface binding, probably because the adhesion site of PAPP-A is occupied by heparan sulfate, known to be covalently bound to proMBP.	Heparitin Sulfate	247-262	pappalysin 1	Homo sapiens	139-145
12370176-11	2002	Interestingly, the proteolytically inactive, disulfide-bound complex of PAPP-A and the proform of eosinophil major basic protein (proMBP), PAPP-A.proMBP, shows only weak surface binding, probably because the adhesion site of PAPP-A is occupied by heparan sulfate, known to be covalently bound to proMBP.	Heparitin Sulfate	247-262	pappalysin 1	Homo sapiens	139-145
12414995-5	2002	Furthermore, exogenous heparan sulphate inhibits rather than assists GDNF signalling.	Heparitin Sulfate	23-39	glial cell derived neurotrophic factor	Rattus norvegicus	69-73
12414995-6	2002	The involvement of heparan sulphates in GDNF signalling raises the possibility that modulation of heparan expression may modulate signalling by GDNF in vivo.	Heparitin Sulfate	19-36	glial cell derived neurotrophic factor	Rattus norvegicus	40-44
12529676-5	2003	Competition experiments showed that 125I-SDF-1 alpha binding to the BMEC cell line 4LHBMEC was inhibited by heparins, heparan sulfate (HS) intestinal mucosa, chondroitin and dermatan sulfate (CS/DS), but not by HS bovine kidney.	Heparitin Sulfate	118-133	C-X-C motif chemokine ligand 12	Homo sapiens	41-46
12529676-5	2003	Competition experiments showed that 125I-SDF-1 alpha binding to the BMEC cell line 4LHBMEC was inhibited by heparins, heparan sulfate (HS) intestinal mucosa, chondroitin and dermatan sulfate (CS/DS), but not by HS bovine kidney.	Heparitin Sulfate	135-137	C-X-C motif chemokine ligand 12	Homo sapiens	41-46
12529676-10	2003	In conclusion, SDF-1 is produced by BMEC and binds to the BMEC cell surface via HS and CS/DS-GAGs, thereby presenting its CXCR4 binding site to HPC contributing to their arrest.	Heparitin Sulfate	80-82	C-X-C motif chemokine ligand 12	Homo sapiens	15-20
12417402-0	2002	Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes.	Heparitin Sulfate	0-15	sulfotransferase family 1D, member 1	Mus musculus	93-111
12381729-5	2002	The rPAI-1(23) isoform can regulate the functional activity of heparan sulfate-binding VEGF-A isoforms by blocking the activation of VEGF from heparan sulfate.	Heparitin Sulfate	63-78	vascular endothelial growth factor A	Gallus gallus	87-93
12381729-5	2002	The rPAI-1(23) isoform can regulate the functional activity of heparan sulfate-binding VEGF-A isoforms by blocking the activation of VEGF from heparan sulfate.	Heparitin Sulfate	63-78	vascular endothelial growth factor A	Gallus gallus	87-91
12381729-5	2002	The rPAI-1(23) isoform can regulate the functional activity of heparan sulfate-binding VEGF-A isoforms by blocking the activation of VEGF from heparan sulfate.	Heparitin Sulfate	143-158	vascular endothelial growth factor A	Gallus gallus	87-93
12381729-5	2002	The rPAI-1(23) isoform can regulate the functional activity of heparan sulfate-binding VEGF-A isoforms by blocking the activation of VEGF from heparan sulfate.	Heparitin Sulfate	143-158	vascular endothelial growth factor A	Gallus gallus	87-91
12454600-1	2002	Syndecan-1 is the prototypic member of a family of heparan sulfate-bearing cell surface proteoglycans that function in adhesion, cell-extracellular matrix interactions, migration, and proliferation.	Heparitin Sulfate	51-66	syndecan 1	Homo sapiens	0-10
12237301-7	2002	Our data are consistent with a model of endostatin with two binding sites: one mainly to laminin in the basement membrane and the other to heparan sulfates on the cell surface.	Heparitin Sulfate	139-155	collagen type XVIII alpha 1 chain	Homo sapiens	40-50
12441129-1	2002	Heparanase is an endo-beta-D-glucuronidase involved in degradation of heparan sulfate (HS) and extracellular matrix (ECM) of a wide range of cells of vertebrate and invertebrate tissues.	Heparitin Sulfate	70-85	heparanase	Homo sapiens	0-10
12441129-1	2002	Heparanase is an endo-beta-D-glucuronidase involved in degradation of heparan sulfate (HS) and extracellular matrix (ECM) of a wide range of cells of vertebrate and invertebrate tissues.	Heparitin Sulfate	70-85	glucuronidase beta	Homo sapiens	22-42
12441129-1	2002	Heparanase is an endo-beta-D-glucuronidase involved in degradation of heparan sulfate (HS) and extracellular matrix (ECM) of a wide range of cells of vertebrate and invertebrate tissues.	Heparitin Sulfate	87-89	heparanase	Homo sapiens	0-10
12441129-1	2002	Heparanase is an endo-beta-D-glucuronidase involved in degradation of heparan sulfate (HS) and extracellular matrix (ECM) of a wide range of cells of vertebrate and invertebrate tissues.	Heparitin Sulfate	87-89	glucuronidase beta	Homo sapiens	22-42
12440867-3	2002	Mono- and disaccharide-containing glycopolymers were synthesized by two different free-radical processes, and their ability to act as heparan sulfate glycomimetics in promoting the binding of Fibroblast Growth Factor-2 (FGF-2) to its receptor (FGFR-1) was evaluated using an in vitro cell-based assay.	Heparitin Sulfate	134-149	fibroblast growth factor 2	Homo sapiens	192-218
12213822-2	2002	Human heparanase is an endo-beta-d-glucuronidase that degrades heparan sulfate/heparin and has been implicated in a variety of biological processes, such as inflammation, tumor angiogenesis, and metastasis.	Heparitin Sulfate	63-78	glucuronidase beta	Homo sapiens	28-48
12485860-0	2002	Increased in vitro cytotoxicity of TNF-alpha analog LK-805 is based on the interaction with cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	105-120	tumor necrosis factor	Mus musculus	35-44
12440867-3	2002	Mono- and disaccharide-containing glycopolymers were synthesized by two different free-radical processes, and their ability to act as heparan sulfate glycomimetics in promoting the binding of Fibroblast Growth Factor-2 (FGF-2) to its receptor (FGFR-1) was evaluated using an in vitro cell-based assay.	Heparitin Sulfate	134-149	fibroblast growth factor 2	Homo sapiens	220-225
12440867-3	2002	Mono- and disaccharide-containing glycopolymers were synthesized by two different free-radical processes, and their ability to act as heparan sulfate glycomimetics in promoting the binding of Fibroblast Growth Factor-2 (FGF-2) to its receptor (FGFR-1) was evaluated using an in vitro cell-based assay.	Heparitin Sulfate	134-149	fibroblast growth factor receptor 1	Homo sapiens	244-250
12489489-2	2002	Heparanase is an endo-beta-D-glucuronidase that cleaves negatively charged heparan sulfate side chains in the basement membrane and extracellular matrix.	Heparitin Sulfate	75-90	glucuronidase beta	Homo sapiens	22-42
12460940-0	2002	Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.	Heparitin Sulfate	8-24	fibroblast growth factor 2	Mus musculus	87-90
12489489-5	2002	Heparanase activity resulted in the conversion of a high molecular weight sulfate-labeled HSPG into heparan sulfate degradation fragments as determined by gel filtration analysis.	Heparitin Sulfate	100-115	syndecan 2	Homo sapiens	90-94
12209938-0	2002	Loading of collagen-heparan sulfate matrices with bFGF promotes angiogenesis and tissue generation in rats.	Heparitin Sulfate	20-35	fibroblast growth factor 2	Rattus norvegicus	50-54
12458045-2	2002	Abeta plaques also contain significant amounts of heparan sulfate proteoglycans (HSPGs), such as agrin, as well as numerous activated microglia expressing increased levels complement receptor 3 (CR3).	Heparitin Sulfate	50-65	amyloid beta precursor protein	Homo sapiens	0-5
12194984-2	2002	Previously, we showed that syndecan-3, a cell surface heparan sulfate proteoglycan, is expressed by proliferating chondrocytes in vivo and that proliferation of cultured chondrocytes in vitro is sensitive to heparitinase treatment.	Heparitin Sulfate	54-69	syndecan 3	Gallus gallus	27-37
12391246-4	2002	Fucoidin, heparin/heparin sulfate, N-acetyl-D-glucosamine, mannose-6-phosphate, and laminarin were found to inhibit adhesion of T84 cells to CD11b/CD18.	Heparitin Sulfate	18-33	integrin subunit alpha M	Homo sapiens	141-146
12391246-4	2002	Fucoidin, heparin/heparin sulfate, N-acetyl-D-glucosamine, mannose-6-phosphate, and laminarin were found to inhibit adhesion of T84 cells to CD11b/CD18.	Heparitin Sulfate	18-33	integrin subunit beta 2	Homo sapiens	147-151
12408231-0	2002	Collagen XVIII: a novel heparan sulfate proteoglycan associated with vascular amyloid depositions and senile plaques in Alzheimer"s disease brains.	Heparitin Sulfate	24-39	collagen type XVIII alpha 1 chain	Homo sapiens	0-14
12408231-2	2002	Recently, it has been demonstrated that the human extracellular matrix-associated molecule collagen XVIII is the first collagen carrying heparan sulfate side-chains.	Heparitin Sulfate	137-152	collagen type XVIII alpha 1 chain	Homo sapiens	91-105
12408231-9	2002	We conclude that collagen XVIII is a novel heparan sulfate proteoglycan associated with vascular A beta and classic senile plaques and that at least the long form of collagen XVIII accumulates in amyloid-laden vessels and classic senile plaques.	Heparitin Sulfate	43-58	collagen type XVIII alpha 1 chain	Homo sapiens	17-31
12391315-3	2002	We found that sqv-4 encodes a protein similar to UDP-glucose dehydrogenases and showed that the SQV-4 protein specifically catalyzes the conversion of UDP-glucose to UDP-glucuronic acid, which is essential for the biosynthesis of chondroitin and heparan sulfate proteoglycans.	Heparitin Sulfate	246-261	UDP-glucose 6-dehydrogenase	Caenorhabditis elegans	14-19
12391315-3	2002	We found that sqv-4 encodes a protein similar to UDP-glucose dehydrogenases and showed that the SQV-4 protein specifically catalyzes the conversion of UDP-glucose to UDP-glucuronic acid, which is essential for the biosynthesis of chondroitin and heparan sulfate proteoglycans.	Heparitin Sulfate	246-261	UDP-glucose 6-dehydrogenase	Caenorhabditis elegans	96-101
12351414-6	2002	This process is dependent on interaction of OPG with heparan sulfates on the myeloma cells.	Heparitin Sulfate	53-69	TNF receptor superfamily member 11b	Homo sapiens	44-47
12423248-0	2002	Internalization of basic fibroblast growth factor at the mouse blood-brain barrier involves perlecan, a heparan sulfate proteoglycan.	Heparitin Sulfate	104-119	fibroblast growth factor 2	Mus musculus	19-49
12084721-6	2002	Heparin or heparan sulfate displaces FGF3 from binding sites on the cell surface inhibiting the growth of DMI cells and reverts the transformed phenotype ().	Heparitin Sulfate	11-26	fibroblast growth factor 3	Mus musculus	37-41
12512896-13	2002	Cochlear perilymph FGF-1 was consistently bound to heparan sulphate proteoglycan (HSPG).	Heparitin Sulfate	51-67	fibroblast growth factor 1	Cavia porcellus	19-24
12270958-1	2002	The heparan sulfate proteoglycan agrin is responsible for the formation, maintenance, and regeneration of the neuromuscular junction.	Heparitin Sulfate	4-19	agrin	Homo sapiens	33-38
12077130-2	2002	Heparanase, an endo-beta-glucuronidase capable of cleaving heparan sulfate, has been demonstrated to contribute to the physiological degradation of heparan sulfate proteoglycans and therefore regulation of their biological functions.	Heparitin Sulfate	59-74	heparanase	Rattus norvegicus	0-10
12077130-2	2002	Heparanase, an endo-beta-glucuronidase capable of cleaving heparan sulfate, has been demonstrated to contribute to the physiological degradation of heparan sulfate proteoglycans and therefore regulation of their biological functions.	Heparitin Sulfate	59-74	glucuronidase, beta	Rattus norvegicus	20-38
12077130-5	2002	Cleavage sites of rat heparanase were present in heparan sulfate chains obtained from a variety of animal organs, but their occurrence was infrequent (average, 1-2 sites per chain) requiring recognition of both undersulfated and sulfated regions of heparan sulfate.	Heparitin Sulfate	49-64	heparanase	Rattus norvegicus	22-32
12077148-2	2002	We have investigated the structural requirements for heparin/heparan sulfate in binding and activation of FGF8 (splice variant b).	Heparitin Sulfate	61-76	fibroblast growth factor 8	Homo sapiens	106-110
12084721-12	2002	Because NIH3T3 cells do not express the high affinity tyrosine kinase FGF receptors for FGF3, these findings suggest that FGF3 attached to GPI-linked heparan sulfate-proteoglycan may have a broader biological activity as when bound to transmembrane or soluble heparan sulfate-proteoglycan.	Heparitin Sulfate	150-165	fibroblast growth factor 3	Mus musculus	122-126
12080045-4	2002	The 3-O-sulfated heparan sulfate is generated by the heparan sulfate d-glucosaminyl-3-O-sulfotransferase isoform 3 (3-OST-3), and it provides binding sites for viral glycoprotein D (gD).	Heparitin Sulfate	17-32	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	166-180
12077130-5	2002	Cleavage sites of rat heparanase were present in heparan sulfate chains obtained from a variety of animal organs, but their occurrence was infrequent (average, 1-2 sites per chain) requiring recognition of both undersulfated and sulfated regions of heparan sulfate.	Heparitin Sulfate	249-264	heparanase	Rattus norvegicus	22-32
12077130-8	2002	O-Sulfation of heparan sulfate chains also played important roles in substrate recognition, implying that rat parathyroid heparanase acts near the boundary of highly sulfated and undersulfated domains of heparan sulfate proteoglycans.	Heparitin Sulfate	15-30	heparanase	Rattus norvegicus	122-132
12077130-9	2002	Further elucidation of the roles of heparanase in normal physiological processes would provide an important tool for analyzing the regulation of heparan sulfate-dependent cell functions.	Heparitin Sulfate	145-160	heparanase	Rattus norvegicus	36-46
12080045-4	2002	The 3-O-sulfated heparan sulfate is generated by the heparan sulfate d-glucosaminyl-3-O-sulfotransferase isoform 3 (3-OST-3), and it provides binding sites for viral glycoprotein D (gD).	Heparitin Sulfate	53-68	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	166-180
12084721-12	2002	Because NIH3T3 cells do not express the high affinity tyrosine kinase FGF receptors for FGF3, these findings suggest that FGF3 attached to GPI-linked heparan sulfate-proteoglycan may have a broader biological activity as when bound to transmembrane or soluble heparan sulfate-proteoglycan.	Heparitin Sulfate	260-275	fibroblast growth factor 3	Mus musculus	122-126
12176868-0	2002	Characterization of the binding site on heparan sulfate for macrophage inflammatory protein 1alpha.	Heparitin Sulfate	40-55	C-C motif chemokine ligand 3	Homo sapiens	60-98
12209563-1	2002	Syndecan-4 (syn-4), a transmembrane heparan sulfate-containing proteoglycan, is unique among the four members of the syndecan family in its specific cellular localization to complex cytoskeletal adhesion sites, i.e., focal adhesions.	Heparitin Sulfate	36-51	syndecan 4	Rattus norvegicus	0-10
12209563-1	2002	Syndecan-4 (syn-4), a transmembrane heparan sulfate-containing proteoglycan, is unique among the four members of the syndecan family in its specific cellular localization to complex cytoskeletal adhesion sites, i.e., focal adhesions.	Heparitin Sulfate	36-51	syndecan 4	Rattus norvegicus	12-17
12230119-0	2002	A possible mechanism for the exchange of transferrin-67Ga complex to heparan sulfate-67Ga complex.	Heparitin Sulfate	69-84	transferrin	Homo sapiens	41-52
12230119-1	2002	We attempted to identify the exchange mechanism of transferrin-67Ga complex to heparan sulfate-67Ga complex.	Heparitin Sulfate	79-94	transferrin	Homo sapiens	51-62
12230119-4	2002	The results suggest that the phosphate is involved in the translocation of 67Ga from the transferrin to the heparan sulfate.	Heparitin Sulfate	108-123	transferrin	Homo sapiens	89-100
12176868-2	2002	The activity of MIP1alpha appears to be modulated by its binding to heparan sulfate (HS) proteoglycans, ubiquitous components of the mammalian cell surface and extracellular matrix.	Heparitin Sulfate	68-83	C-C motif chemokine ligand 3	Homo sapiens	16-25
12176868-2	2002	The activity of MIP1alpha appears to be modulated by its binding to heparan sulfate (HS) proteoglycans, ubiquitous components of the mammalian cell surface and extracellular matrix.	Heparitin Sulfate	85-87	C-C motif chemokine ligand 3	Homo sapiens	16-25
12176868-3	2002	In this study we show that HS has highest affinity for the dimeric form of MIP1alpha.	Heparitin Sulfate	27-29	C-C motif chemokine ligand 3	Homo sapiens	75-84
12455720-0	2002	Effect of heparan sulphate on kidney tissue expression of TGF-beta, rhoA, laminin and fibronectin in subtotally nephrectomized rats.	Heparitin Sulfate	10-26	transforming growth factor, beta 1	Rattus norvegicus	58-66
12165810-2	2002	CD44 variant exon 3 (CD44v3), a receptor for heparan sulfate, generates intracellular signals for cell migration.	Heparitin Sulfate	45-60	CD44 molecule (Indian blood group)	Homo sapiens	0-4
12455720-5	2002	Since the Ras transduction pathway has recently been associated with progression of renal damage, we evaluated the effect of heparan sulphate (HS) on the expression of TGF-beta, laminin, fibronectin and a Ras protein, RhoA, in the rat remnant kidney model.	Heparitin Sulfate	125-141	transforming growth factor, beta 1	Rattus norvegicus	168-176
12455720-5	2002	Since the Ras transduction pathway has recently been associated with progression of renal damage, we evaluated the effect of heparan sulphate (HS) on the expression of TGF-beta, laminin, fibronectin and a Ras protein, RhoA, in the rat remnant kidney model.	Heparitin Sulfate	125-141	fibronectin 1	Rattus norvegicus	187-198
12455720-5	2002	Since the Ras transduction pathway has recently been associated with progression of renal damage, we evaluated the effect of heparan sulphate (HS) on the expression of TGF-beta, laminin, fibronectin and a Ras protein, RhoA, in the rat remnant kidney model.	Heparitin Sulfate	143-145	transforming growth factor, beta 1	Rattus norvegicus	168-176
12455720-5	2002	Since the Ras transduction pathway has recently been associated with progression of renal damage, we evaluated the effect of heparan sulphate (HS) on the expression of TGF-beta, laminin, fibronectin and a Ras protein, RhoA, in the rat remnant kidney model.	Heparitin Sulfate	143-145	fibronectin 1	Rattus norvegicus	187-198
12163630-2	2002	Because Abeta plaques are characteristic of AD and Abeta deposits contain abundant heparan sulfate proteoglycans that can bind basic fibroblast growth factor (bFGF) and serum amyloid P component (SAP), we investigated a novel route of ligand delivery to the brain to assess Abeta deposition in a transgenic (Tg) mouse model overexpressing Abeta-protein precursor.	Heparitin Sulfate	83-98	amyloid beta (A4) precursor protein	Mus musculus	8-13
12034712-0	2002	Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate.	Heparitin Sulfate	77-92	fibroblast growth factor receptor 1	Homo sapiens	0-42
12034712-2	2002	Heparan sulfate (HS) regulates the kinetics of fibroblast growth factor 2 (FGF2)-stimulated intracellular signaling and differentially activates cell proliferation of cells expressing different FGF receptors (FGFRs).	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	47-73
12034712-2	2002	Heparan sulfate (HS) regulates the kinetics of fibroblast growth factor 2 (FGF2)-stimulated intracellular signaling and differentially activates cell proliferation of cells expressing different FGF receptors (FGFRs).	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	75-79
12034712-2	2002	Heparan sulfate (HS) regulates the kinetics of fibroblast growth factor 2 (FGF2)-stimulated intracellular signaling and differentially activates cell proliferation of cells expressing different FGF receptors (FGFRs).	Heparitin Sulfate	17-19	fibroblast growth factor 2	Homo sapiens	47-73
12034712-2	2002	Heparan sulfate (HS) regulates the kinetics of fibroblast growth factor 2 (FGF2)-stimulated intracellular signaling and differentially activates cell proliferation of cells expressing different FGF receptors (FGFRs).	Heparitin Sulfate	17-19	fibroblast growth factor 2	Homo sapiens	75-79
12430897-5	2002	Ryudocan is a cell surface heparan sulfate proteoglycan, which bears heparin-like glycosaminoglycan (heparan sulfate) cahins, originally cloned from rat microvascular endothelial cells.	Heparitin Sulfate	27-42	syndecan 4	Mus musculus	0-8
12430897-5	2002	Ryudocan is a cell surface heparan sulfate proteoglycan, which bears heparin-like glycosaminoglycan (heparan sulfate) cahins, originally cloned from rat microvascular endothelial cells.	Heparitin Sulfate	101-116	syndecan 4	Mus musculus	0-8
12212792-5	2002	The offending BM component is a heparan sulfate (HS) proteoglycan (HSPG), part of which is protein and the remainder a specific linear polysaccharide, which is the portion responsible for binding, and imparting the typical amyloid structure, to the amyloid precursor protein/peptide.	Heparitin Sulfate	32-47	syndecan 2	Homo sapiens	67-71
12212792-5	2002	The offending BM component is a heparan sulfate (HS) proteoglycan (HSPG), part of which is protein and the remainder a specific linear polysaccharide, which is the portion responsible for binding, and imparting the typical amyloid structure, to the amyloid precursor protein/peptide.	Heparitin Sulfate	49-51	syndecan 2	Homo sapiens	67-71
12163592-0	2002	Retrovirus-associated heparan sulfate mediates immobilization and gene transfer on recombinant fibronectin.	Heparitin Sulfate	22-37	fibronectin 1	Homo sapiens	95-106
12163592-7	2002	Our results clearly show that retrovirus binds FN through virus-associated heparan sulfate (HS) and that binding is necessary for transduction without PB.	Heparitin Sulfate	75-90	fibronectin 1	Homo sapiens	47-49
12163592-7	2002	Our results clearly show that retrovirus binds FN through virus-associated heparan sulfate (HS) and that binding is necessary for transduction without PB.	Heparitin Sulfate	92-94	fibronectin 1	Homo sapiens	47-49
12196138-5	2002	To assess potential cofactors in PrP conversion, we used cell-free PrP conversion assays to show that heparan sulphate can stimulate PrP-res formation, supporting the idea that endogenous sulphated glycosaminoglycans can act as important cofactors or modulators of PrP-res formation in vivo.	Heparitin Sulfate	102-118	prion protein	Homo sapiens	33-36
12212792-7	2002	The present work is concerned with the design and synthesis of modified sugar precursors of HS, which, when incorporated into the polysaccharide, will alter its structure so that it loses its amyloid precursor protein/peptide-binding and fibril-inducing properties.	Heparitin Sulfate	92-94	amyloid beta precursor protein	Homo sapiens	192-217
12163630-2	2002	Because Abeta plaques are characteristic of AD and Abeta deposits contain abundant heparan sulfate proteoglycans that can bind basic fibroblast growth factor (bFGF) and serum amyloid P component (SAP), we investigated a novel route of ligand delivery to the brain to assess Abeta deposition in a transgenic (Tg) mouse model overexpressing Abeta-protein precursor.	Heparitin Sulfate	83-98	fibroblast growth factor 2	Mus musculus	127-157
12163630-2	2002	Because Abeta plaques are characteristic of AD and Abeta deposits contain abundant heparan sulfate proteoglycans that can bind basic fibroblast growth factor (bFGF) and serum amyloid P component (SAP), we investigated a novel route of ligand delivery to the brain to assess Abeta deposition in a transgenic (Tg) mouse model overexpressing Abeta-protein precursor.	Heparitin Sulfate	83-98	fibroblast growth factor 2	Mus musculus	159-163
12163630-2	2002	Because Abeta plaques are characteristic of AD and Abeta deposits contain abundant heparan sulfate proteoglycans that can bind basic fibroblast growth factor (bFGF) and serum amyloid P component (SAP), we investigated a novel route of ligand delivery to the brain to assess Abeta deposition in a transgenic (Tg) mouse model overexpressing Abeta-protein precursor.	Heparitin Sulfate	83-98	amyloid P component, serum	Mus musculus	169-194
12163630-2	2002	Because Abeta plaques are characteristic of AD and Abeta deposits contain abundant heparan sulfate proteoglycans that can bind basic fibroblast growth factor (bFGF) and serum amyloid P component (SAP), we investigated a novel route of ligand delivery to the brain to assess Abeta deposition in a transgenic (Tg) mouse model overexpressing Abeta-protein precursor.	Heparitin Sulfate	83-98	amyloid P component, serum	Mus musculus	196-199
12163630-2	2002	Because Abeta plaques are characteristic of AD and Abeta deposits contain abundant heparan sulfate proteoglycans that can bind basic fibroblast growth factor (bFGF) and serum amyloid P component (SAP), we investigated a novel route of ligand delivery to the brain to assess Abeta deposition in a transgenic (Tg) mouse model overexpressing Abeta-protein precursor.	Heparitin Sulfate	83-98	amyloid beta (A4) precursor protein	Mus musculus	51-56
12163630-2	2002	Because Abeta plaques are characteristic of AD and Abeta deposits contain abundant heparan sulfate proteoglycans that can bind basic fibroblast growth factor (bFGF) and serum amyloid P component (SAP), we investigated a novel route of ligand delivery to the brain to assess Abeta deposition in a transgenic (Tg) mouse model overexpressing Abeta-protein precursor.	Heparitin Sulfate	83-98	amyloid beta (A4) precursor protein	Mus musculus	51-56
12091355-1	2002	Syndecan-1 (CD138) is a transmembrane heparan sulfate-bearing proteoglycan expressed by most myeloma plasma cells that regulates adhesion, migration, and growth factor activity.	Heparitin Sulfate	38-53	syndecan 1	Homo sapiens	0-10
12139612-3	2002	Recombinant Plasmodium falciparum CS protein and TRAP bind to heparan sulphate on hepatocytes and both heparan and chondroitin sulphate proteoglycans on stellate cells.	Heparitin Sulfate	62-78	TRAP	Homo sapiens	49-53
12244479-4	2002	The pentasaccharide corresponding to the active site of heparin/heparan sulfate for antithrombin (AT) adopts in the complex with the protein a conformation different from that in the absence of the protein.	Heparitin Sulfate	64-79	serpin family C member 1	Homo sapiens	84-96
12219030-2	2002	Heparanase-1 (HPR1) is an endoglycosidase that specifically degrades the heparan sulfate (HS) moiety of proteoglycans, a component of the extracellular matrix and basement membrane.	Heparitin Sulfate	73-88	heparanase	Homo sapiens	0-12
12219030-2	2002	Heparanase-1 (HPR1) is an endoglycosidase that specifically degrades the heparan sulfate (HS) moiety of proteoglycans, a component of the extracellular matrix and basement membrane.	Heparitin Sulfate	73-88	heparanase	Homo sapiens	14-18
12219030-2	2002	Heparanase-1 (HPR1) is an endoglycosidase that specifically degrades the heparan sulfate (HS) moiety of proteoglycans, a component of the extracellular matrix and basement membrane.	Heparitin Sulfate	90-92	heparanase	Homo sapiens	0-12
12219030-2	2002	Heparanase-1 (HPR1) is an endoglycosidase that specifically degrades the heparan sulfate (HS) moiety of proteoglycans, a component of the extracellular matrix and basement membrane.	Heparitin Sulfate	90-92	heparanase	Homo sapiens	14-18
12091355-1	2002	Syndecan-1 (CD138) is a transmembrane heparan sulfate-bearing proteoglycan expressed by most myeloma plasma cells that regulates adhesion, migration, and growth factor activity.	Heparitin Sulfate	38-53	syndecan 1	Homo sapiens	12-17
19810942-3	2002	Heparanase is an endo-beta-D-glucuronidase that degrades the heparan sulfate chains of heparan sulfate proteoglycans, essential and ubiquitous macromolecules associated with the cell surface and the extracellular matrix of a wide range of cells and tissues.	Heparitin Sulfate	61-76	heparanase	Homo sapiens	0-10
12110435-2	2002	EXT1 and EXT2 function as glycosyltransferases that participate in the biosynthesis of heparan sulfate (HS) to modify proteoglycans.	Heparitin Sulfate	87-102	exostosin glycosyltransferase 1	Homo sapiens	0-4
12110435-2	2002	EXT1 and EXT2 function as glycosyltransferases that participate in the biosynthesis of heparan sulfate (HS) to modify proteoglycans.	Heparitin Sulfate	87-102	exostosin glycosyltransferase 2	Homo sapiens	9-13
12110435-2	2002	EXT1 and EXT2 function as glycosyltransferases that participate in the biosynthesis of heparan sulfate (HS) to modify proteoglycans.	Heparitin Sulfate	104-106	exostosin glycosyltransferase 1	Homo sapiens	0-4
12110435-2	2002	EXT1 and EXT2 function as glycosyltransferases that participate in the biosynthesis of heparan sulfate (HS) to modify proteoglycans.	Heparitin Sulfate	104-106	exostosin glycosyltransferase 2	Homo sapiens	9-13
12453641-1	2002	Our previous studies indicated that cell surface proteoglycans were mostly heparan sulfate ones (HSPG) in 20 day-old Sertoli cells [Biochim.	Heparitin Sulfate	75-90	syndecan 1	Rattus norvegicus	97-101
19810942-3	2002	Heparanase is an endo-beta-D-glucuronidase that degrades the heparan sulfate chains of heparan sulfate proteoglycans, essential and ubiquitous macromolecules associated with the cell surface and the extracellular matrix of a wide range of cells and tissues.	Heparitin Sulfate	61-76	glucuronidase beta	Homo sapiens	22-42
12074629-0	2002	Modulation of microvascular signaling by heparan sulfate matrix: studies in syndecan-4 transgenic mice.	Heparitin Sulfate	41-56	syndecan 4	Mus musculus	76-86
12118087-9	2002	Biochemical analyses demonstrated that this second site constitutes a heparan sulfate, which directly interacted with the type I receptor after recruitment to the complex, and which bound up to 50% and 25% of the ligand after fibronectin attachment and PDGF stimulation, respectively.	Heparitin Sulfate	70-85	fibronectin 1	Homo sapiens	226-237
12127836-11	2002	In agarose diffusion assays IGFBP-3 interacted with fibronectin and heparan sulfate proteoglycan but not with type VI collagen or tenascin-C.	Heparitin Sulfate	68-83	insulin like growth factor binding protein 3	Homo sapiens	28-35
12069613-4	2002	ApoE is a heparan-sulfate binding protein, and apoE peptide neurotoxicity can be blocked by heparin and prevented by degrading heparan sulfate or inhibiting its biosynthesis.	Heparitin Sulfate	10-25	apolipoprotein E	Homo sapiens	0-4
12069613-4	2002	ApoE is a heparan-sulfate binding protein, and apoE peptide neurotoxicity can be blocked by heparin and prevented by degrading heparan sulfate or inhibiting its biosynthesis.	Heparitin Sulfate	10-25	apolipoprotein E	Homo sapiens	47-51
12069613-4	2002	ApoE is a heparan-sulfate binding protein, and apoE peptide neurotoxicity can be blocked by heparin and prevented by degrading heparan sulfate or inhibiting its biosynthesis.	Heparitin Sulfate	127-142	apolipoprotein E	Homo sapiens	0-4
12069613-4	2002	ApoE is a heparan-sulfate binding protein, and apoE peptide neurotoxicity can be blocked by heparin and prevented by degrading heparan sulfate or inhibiting its biosynthesis.	Heparitin Sulfate	127-142	apolipoprotein E	Homo sapiens	47-51
12047378-3	2002	Mutating four cationic residues in the C-terminal portion of sPLA(2)-IID resulted in abolition of its ability to associate with cell surface heparan sulfate and to enhance stimulus-induced delayed arachidonate release, cyclooxygenase-2 induction, and prostaglandin generation in 293 cell transfectants.	Heparitin Sulfate	141-156	phospholipase A2 group IID	Homo sapiens	61-72
11950836-1	2002	Beta1,3-glucuronyltransferase (GlcAT-I) is an essential enzyme involved in heparan sulfate and chondroitin sulfate biosynthesis.	Heparitin Sulfate	75-90	beta-1,3-glucuronyltransferase 3	Homo sapiens	31-38
12069854-0	2002	Early-glycation of apolipoprotein E: effect on its binding to LDL receptor, scavenger receptor A and heparan sulfates.	Heparitin Sulfate	101-117	apolipoprotein E	Homo sapiens	19-35
12069854-4	2002	Glycated apoE binding to heparin and heparan sulfates (HS) was assessed by surface plasmon resonance (SPR) technology.	Heparitin Sulfate	55-57	apolipoprotein E	Homo sapiens	9-13
12021366-1	2002	Cell surface glycosaminoglycans (GAGs), in particular heparan sulfate (HS), have been proposed to mediate the attachment of human immunodeficiency virus type 1 (HIV-1) to target cells prior to virus entry, and both the viral gp120 envelope protein and virion-associated cyclophilin A (CypA) have been shown to directly interact with HS and its analogues.	Heparitin Sulfate	54-69	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	225-230
11909863-8	2002	Perlecan contained 25% heparan sulfate and 75% chondroitin sulfate.	Heparitin Sulfate	23-38	heparan sulfate proteoglycan 2	Bos taurus	0-8
12094292-5	2002	The inhibitory activity of Na-SP was the strongest when compared to that of heparan sulfate, heparin, dextran sulfate, dermatan sulfate, chondroitin sulfate A/C and hyaluronan.	Heparitin Sulfate	76-91	nuclear autoantigenic sperm protein	Bos taurus	27-32
11889131-1	2002	Syndecan-4 is a heparan sulfate-carrying core protein that has been directly implicated in fibroblast growth factor 2 (FGF2) signaling.	Heparitin Sulfate	16-31	syndecan 4	Homo sapiens	0-10
11889131-1	2002	Syndecan-4 is a heparan sulfate-carrying core protein that has been directly implicated in fibroblast growth factor 2 (FGF2) signaling.	Heparitin Sulfate	16-31	fibroblast growth factor 2	Homo sapiens	91-117
11909863-9	2002	The heparan sulfate chains on growth plate perlecan were considerably smaller than the chondroitin sulfate chains, and the heparan sulfate disaccharide content was different than that found for heparan sulfate from either kidney, tumor tissue, or growth plate aggrecan.	Heparitin Sulfate	4-19	heparan sulfate proteoglycan 2	Bos taurus	43-51
11889131-1	2002	Syndecan-4 is a heparan sulfate-carrying core protein that has been directly implicated in fibroblast growth factor 2 (FGF2) signaling.	Heparitin Sulfate	16-31	fibroblast growth factor 2	Homo sapiens	119-123
11909863-11	2002	These results indicate that perlecan and aggrecan would be the principal candidate proteoglycans involved in the action of heparan sulfate-binding proteins in the developing growth plate.	Heparitin Sulfate	123-138	heparan sulfate proteoglycan 2	Bos taurus	28-36
11973346-9	2002	Furthermore, histone H1 incorporated into the extracellular matrix strongly stimulated myoblast proliferation via a heparan-sulfate-dependent mechanism.	Heparitin Sulfate	116-131	H1.0 linker histone	Homo sapiens	13-23
11994480-0	2002	Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4.	Heparitin Sulfate	75-90	toll like receptor 4	Homo sapiens	94-114
11973358-1	2002	Heparanase is a heparan-sulfate-degrading endoglycosidase that has important roles in various biological processes, including angiogenesis, wound healing and metastatsis.	Heparitin Sulfate	16-31	heparanase	Homo sapiens	0-10
11973358-3	2002	Extracellular heparanase is found in various tissues and is utilized by both normal cells and metastatic cancer cells to degrade heparan sulfate moieties in basement membranes and extracellular matrices.	Heparitin Sulfate	129-144	heparanase	Homo sapiens	14-24
11973358-8	2002	Heparin completely inhibits heparanase endocytosis but only partially inhibits its association with the cells, suggesting that cell surface heparan sulfate moieties play a specific role in its endocytosis.	Heparitin Sulfate	140-155	heparanase	Homo sapiens	28-38
12075747-1	2002	BACKGROUND: The novel molecule PI-88 is a highly sulfonated oligosaccharide which inhibits heparanase activity and competes with heparan sulfate binding of growth factors such as FGF and VEGF.	Heparitin Sulfate	129-144	vascular endothelial growth factor A	Homo sapiens	187-191
12028356-7	2002	Considering that NCAM is implicated in the migratory process of LHRH neurons and specifically binds to heparan sulphate, it is likely that a heterophilic interaction between NCAM and N-syndecan participates in the neuronal migration from the rat olfactory placode.	Heparitin Sulfate	103-119	neural cell adhesion molecule 1	Rattus norvegicus	17-21
12028356-7	2002	Considering that NCAM is implicated in the migratory process of LHRH neurons and specifically binds to heparan sulphate, it is likely that a heterophilic interaction between NCAM and N-syndecan participates in the neuronal migration from the rat olfactory placode.	Heparitin Sulfate	103-119	neural cell adhesion molecule 1	Rattus norvegicus	174-178
12028356-7	2002	Considering that NCAM is implicated in the migratory process of LHRH neurons and specifically binds to heparan sulphate, it is likely that a heterophilic interaction between NCAM and N-syndecan participates in the neuronal migration from the rat olfactory placode.	Heparitin Sulfate	103-119	syndecan 3	Rattus norvegicus	183-193
12975615-1	2002	Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3"-phosphoadenosine-5"-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain.	Heparitin Sulfate	129-131	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	40-45
12073527-1	2002	The role of agrin, a large proteoglycan containing heparan-sulfate in the synaptic cleft, has been elucidated in recent years.	Heparitin Sulfate	51-66	agrin	Homo sapiens	12-17
12975610-6	2002	TGF-beta, one of the cytokines involved in the suppression mechanism, bound to heparan sulfate chain of syndecan-4, which was induced in macrophages and the microvasculature after administration of lipopolysaccharide.	Heparitin Sulfate	79-94	syndecan 4	Mus musculus	104-114
12975615-1	2002	Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3"-phosphoadenosine-5"-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain.	Heparitin Sulfate	295-297	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	0-38
12975615-1	2002	Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3"-phosphoadenosine-5"-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain.	Heparitin Sulfate	111-127	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	0-38
12975615-1	2002	Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3"-phosphoadenosine-5"-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain.	Heparitin Sulfate	295-297	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	40-45
12975615-1	2002	Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3"-phosphoadenosine-5"-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain.	Heparitin Sulfate	111-127	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	40-45
12975615-1	2002	Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3"-phosphoadenosine-5"-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain.	Heparitin Sulfate	129-131	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	0-38
12975616-1	2002	Heparan sulfate that contains antithrombin binding sites is designated as anticoagulant heparan sulfate (HS(act)) since, in vitro, it dramatically enhances the neutralization of coagulation proteases by antithrombin.	Heparitin Sulfate	0-15	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	30-42
12975616-1	2002	Heparan sulfate that contains antithrombin binding sites is designated as anticoagulant heparan sulfate (HS(act)) since, in vitro, it dramatically enhances the neutralization of coagulation proteases by antithrombin.	Heparitin Sulfate	0-15	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	203-215
12975616-1	2002	Heparan sulfate that contains antithrombin binding sites is designated as anticoagulant heparan sulfate (HS(act)) since, in vitro, it dramatically enhances the neutralization of coagulation proteases by antithrombin.	Heparitin Sulfate	88-103	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	30-42
12975616-1	2002	Heparan sulfate that contains antithrombin binding sites is designated as anticoagulant heparan sulfate (HS(act)) since, in vitro, it dramatically enhances the neutralization of coagulation proteases by antithrombin.	Heparitin Sulfate	88-103	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	203-215
11956326-0	2002	Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites.	Heparitin Sulfate	145-160	fibroblast growth factor 2	Homo sapiens	57-61
11953369-4	2002	However, the possibility existed that radioiodinated DT-HB-EGF complexes associate with cells due to the binding of the heparin-binding domain of recombinant HB-EGF to cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	181-196	heparin binding EGF like growth factor	Homo sapiens	56-62
11953369-4	2002	However, the possibility existed that radioiodinated DT-HB-EGF complexes associate with cells due to the binding of the heparin-binding domain of recombinant HB-EGF to cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	181-196	heparin binding EGF like growth factor	Homo sapiens	158-164
11956326-0	2002	Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites.	Heparitin Sulfate	145-160	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-87
11956326-0	2002	Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites.	Heparitin Sulfate	145-160	fibroblast growth factor 2	Homo sapiens	161-165
11956326-1	2002	Binding of basic fibroblast growth factor (FGF2) to its high affinity receptors requires the presence of specific heparan sulfate (HS) moieties on the cell surface that act as coreceptors.	Heparitin Sulfate	114-129	fibroblast growth factor 2	Homo sapiens	43-47
11956326-1	2002	Binding of basic fibroblast growth factor (FGF2) to its high affinity receptors requires the presence of specific heparan sulfate (HS) moieties on the cell surface that act as coreceptors.	Heparitin Sulfate	131-133	fibroblast growth factor 2	Homo sapiens	43-47
11991744-4	2002	Enzymatic digestion of heparan sulfate (HS) from the cell surface with heparinase I also reduces VLP binding.	Heparitin Sulfate	23-38	VHL like	Homo sapiens	97-100
11991744-4	2002	Enzymatic digestion of heparan sulfate (HS) from the cell surface with heparinase I also reduces VLP binding.	Heparitin Sulfate	40-42	VHL like	Homo sapiens	97-100
11991744-9	2002	Additionally, our results demonstrate that, in the absence of Polybrene, initial attachments of non-infectious, envelope protein-free VLP and probably mature infectious virus particles are mediated by interactions of the virus particles with cell surface heparan sulfate, and possibly with other GAG molecules.	Heparitin Sulfate	255-270	VHL like	Homo sapiens	134-137
11832488-0	2002	Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation.	Heparitin Sulfate	119-134	brother of tout-velu	Drosophila melanogaster	30-35
11983919-0	2002	Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1.	Heparitin Sulfate	0-15	uncharacterized protein	Caenorhabditis elegans	117-122
11847210-3	2002	Also, recombinant perlecan domains I and V carrying heparan sulfate bound PRELP, whereas other domains without glycosaminoglycan substitution did not.	Heparitin Sulfate	52-67	proline and arginine rich end leucine rich repeat protein	Homo sapiens	74-79
11847210-10	2002	Electron microscopy visualized a complex with PRELP binding simultaneously to the triple helical region of procollagen I and the heparan sulfate chains of perlecan.	Heparitin Sulfate	129-144	proline and arginine rich end leucine rich repeat protein	Homo sapiens	46-51
11847221-1	2002	Human basement membrane heparan sulfate proteoglycan (HSPG) perlecan binds and activates fibroblast growth factor (FGF)-2 through its heparan sulfate (HS) chains.	Heparitin Sulfate	24-39	CD44 molecule (Indian blood group)	Homo sapiens	54-58
11847221-1	2002	Human basement membrane heparan sulfate proteoglycan (HSPG) perlecan binds and activates fibroblast growth factor (FGF)-2 through its heparan sulfate (HS) chains.	Heparitin Sulfate	24-39	fibroblast growth factor 2	Homo sapiens	89-121
11847221-1	2002	Human basement membrane heparan sulfate proteoglycan (HSPG) perlecan binds and activates fibroblast growth factor (FGF)-2 through its heparan sulfate (HS) chains.	Heparitin Sulfate	54-56	CD44 molecule (Indian blood group)	Homo sapiens	24-52
11847221-1	2002	Human basement membrane heparan sulfate proteoglycan (HSPG) perlecan binds and activates fibroblast growth factor (FGF)-2 through its heparan sulfate (HS) chains.	Heparitin Sulfate	54-56	fibroblast growth factor 2	Homo sapiens	89-121
11832488-3	2002	The truncated soluble form of this new homolog designated DEXT3 transferred N-acetylglucosamine (GlcNAc) through an alpha1,4-linkage not only to N-acetylheparosan oligosaccharides that represent growing HS chains (alpha-GlcNAc transferase II activity) but also to GlcUAbeta1-3Galbeta1-O-C(2)H(4)NHCbz, a synthetic substrate for alpha-GlcNAc transferase I that determines and initiates HS biosynthesis.	Heparitin Sulfate	203-205	brother of tout-velu	Drosophila melanogaster	58-63
11832488-7	2002	These results suggest the essential roles of DEXT3, its human ortholog EXTL3, and the C. elegans ortholog rib-2 in the biosynthesis of heparan sulfate and heparin, if present, in the respective organisms.	Heparitin Sulfate	135-150	brother of tout-velu	Drosophila melanogaster	45-50
11832488-7	2002	These results suggest the essential roles of DEXT3, its human ortholog EXTL3, and the C. elegans ortholog rib-2 in the biosynthesis of heparan sulfate and heparin, if present, in the respective organisms.	Heparitin Sulfate	135-150	exostosin like glycosyltransferase 3	Homo sapiens	71-76
11832488-7	2002	These results suggest the essential roles of DEXT3, its human ortholog EXTL3, and the C. elegans ortholog rib-2 in the biosynthesis of heparan sulfate and heparin, if present, in the respective organisms.	Heparitin Sulfate	135-150	Exostosin-2 homolog	Caenorhabditis elegans	106-111
11944914-0	2002	Transgenic expression of the EXT2 gene in developing chondrocytes enhances the synthesis of heparan sulfate and bone formation in mice.	Heparitin Sulfate	92-107	exostosin glycosyltransferase 2	Mus musculus	29-33
11929792-10	2002	We also obtained evidence that secreted mature HGF binds PMN-derived glycosaminoglycans (probably heparan sulfate).	Heparitin Sulfate	98-113	hepatocyte growth factor	Homo sapiens	47-50
11944914-2	2002	Recent studies have revealed that EXT1 and EXT2 are required for the biosynthesis of heparan sulfate and exert maximal transferase activity as a complex.	Heparitin Sulfate	85-100	exostosin glycosyltransferase 1	Mus musculus	34-38
11944914-2	2002	Recent studies have revealed that EXT1 and EXT2 are required for the biosynthesis of heparan sulfate and exert maximal transferase activity as a complex.	Heparitin Sulfate	85-100	exostosin glycosyltransferase 2	Mus musculus	43-47
11944914-5	2002	Histological analyses and micro-CT scanning showed that the biosynthesis of heparan sulfate and the formation of trabeculae were upregulated in EXT2-transgenic mice, but not in mutant EXT2-transgenic mice.	Heparitin Sulfate	76-91	exostosin glycosyltransferase 2	Mus musculus	144-148
11944914-7	2002	These findings support that the EXT2 gene encodes an essential component of the glycosyltransferase complex required for the biosynthesis of heparan sulfate, which may eventually modulate the signaling involved in bone formation.	Heparitin Sulfate	141-156	exostosin glycosyltransferase 2	Mus musculus	32-36
11897702-0	2002	The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	175-190	cellular communication network factor 1	Rattus norvegicus	22-38
11799124-1	2002	Hepatocyte growth factor/scatter factor (HGF/SF) acts via a dual receptor system consisting of the MET tyrosine kinase receptor and heparan sulfate or dermatan sulfate proteoglycans.	Heparitin Sulfate	132-147	hepatocyte growth factor	Homo sapiens	41-47
11897702-0	2002	The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	175-190	cellular communication network factor 1	Rattus norvegicus	40-45
11897702-4	2002	Here we show that purified CYR61 supports VSMC adhesion in a dose-dependent, saturable manner through integrin alpha(6)beta(1) with an absolute requirement of cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	172-187	cellular communication network factor 1	Rattus norvegicus	27-32
12097308-0	2002	Heparan sulfate interacting protein (HIP/L29) negatively regulates growth responses to basic fibroblast growth factor in gingival fibroblasts.	Heparitin Sulfate	0-15	ribosomal protein L29	Homo sapiens	37-44
12097308-0	2002	Heparan sulfate interacting protein (HIP/L29) negatively regulates growth responses to basic fibroblast growth factor in gingival fibroblasts.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	87-117
11861306-6	2002	Exogenous IDUA expression led to a normalization of glycosaminoglycan storage in MPS-IH cells, as evidenced by a dramatic decrease in the amount of (35)SO(4) sequestered within the heparan sulfate and dermatan sulfate compartments of these cells.	Heparitin Sulfate	181-196	alpha-L-iduronidase	Homo sapiens	10-14
11890696-0	2002	Minimal heparin/heparan sulfate sequences for binding to fibroblast growth factor-1.	Heparitin Sulfate	16-31	fibroblast growth factor 1	Homo sapiens	57-83
11890696-1	2002	The glycosaminoglycans heparin and heparan sulfate (HS) bind to fibroblast growth factor FGF1 and promote its dimerization, a proposed prerequisite for binding to a cellular receptor and triggering mitogenic signals.	Heparitin Sulfate	35-50	fibroblast growth factor 1	Homo sapiens	89-93
11890696-1	2002	The glycosaminoglycans heparin and heparan sulfate (HS) bind to fibroblast growth factor FGF1 and promote its dimerization, a proposed prerequisite for binding to a cellular receptor and triggering mitogenic signals.	Heparitin Sulfate	52-54	fibroblast growth factor 1	Homo sapiens	89-93
11890696-5	2002	Furthermore, MALDI experiments show that, in addition to 1:1 protein:tetrasaccharide complexes, AA and BA are able to form 2:1 complexes, indicating that heparin/HS-induced dimerization of FGF1 requires only one 6-OSO(3) group per tetrasaccharide.	Heparitin Sulfate	162-164	fibroblast growth factor 1	Homo sapiens	189-193
11779847-1	2002	Heparanase-1 (HPR1) is an endoglycosidase that specifically degrades the heparan sulfate chains of proteoglycan, a component of blood vessel walls and the extracellular matrix.	Heparitin Sulfate	73-88	heparanase	Homo sapiens	0-12
11779847-1	2002	Heparanase-1 (HPR1) is an endoglycosidase that specifically degrades the heparan sulfate chains of proteoglycan, a component of blood vessel walls and the extracellular matrix.	Heparitin Sulfate	73-88	heparanase	Homo sapiens	14-18
11830493-6	2002	Importantly, the interaction of HGF with heparan sulfate moieties on syndecan-1 strongly promotes HGF-mediated signaling, resulting in enhanced activation of Met, the receptor tyrosine kinase for HGF.	Heparitin Sulfate	41-56	hepatocyte growth factor	Homo sapiens	32-35
11751872-0	2002	Schwann cell adhesion to a novel heparan sulfate binding site in the N-terminal domain of alpha 4 type V collagen is mediated by syndecan-3.	Heparitin Sulfate	33-48	syndecan 3	Rattus norvegicus	129-139
11855924-14	2002	With more than one class of heparanase in their granules, neutrophils may be able to modify different kinds of heparan sulfate chains.	Heparitin Sulfate	111-126	heparanase	Homo sapiens	28-38
11814358-1	2002	The binding of interleukin-8 (IL-8) to heparan sulfate (HS) proteoglycans on the surface of endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site.	Heparitin Sulfate	39-54	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
11814358-1	2002	The binding of interleukin-8 (IL-8) to heparan sulfate (HS) proteoglycans on the surface of endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site.	Heparitin Sulfate	39-54	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
11814358-1	2002	The binding of interleukin-8 (IL-8) to heparan sulfate (HS) proteoglycans on the surface of endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site.	Heparitin Sulfate	56-58	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
11814358-1	2002	The binding of interleukin-8 (IL-8) to heparan sulfate (HS) proteoglycans on the surface of endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site.	Heparitin Sulfate	56-58	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
11846487-1	2002	The type 1 Simpson-Golabi-Behmel overgrowth syndrome (SGBS1) is caused by loss-of-function mutations of the X-linked GPC3 gene encoding glypican-3, a cell-surface heparan sulfate proteoglycan that apparently plays a negative role in growth control by an unknown mechanism.	Heparitin Sulfate	163-178	glypican 3	Mus musculus	117-121
11846487-1	2002	The type 1 Simpson-Golabi-Behmel overgrowth syndrome (SGBS1) is caused by loss-of-function mutations of the X-linked GPC3 gene encoding glypican-3, a cell-surface heparan sulfate proteoglycan that apparently plays a negative role in growth control by an unknown mechanism.	Heparitin Sulfate	163-178	glypican 3	Mus musculus	136-146
11814358-9	2002	Thermal unfolding of IL-8 yielded a single transition at 56 degrees C which was completely prevented by the presence of undigested HS or heparin, indicating structural stabilization, thereby prolonging the biological effect of the chemokine.	Heparitin Sulfate	131-133	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
11830493-6	2002	Importantly, the interaction of HGF with heparan sulfate moieties on syndecan-1 strongly promotes HGF-mediated signaling, resulting in enhanced activation of Met, the receptor tyrosine kinase for HGF.	Heparitin Sulfate	41-56	syndecan 1	Homo sapiens	69-79
11830493-6	2002	Importantly, the interaction of HGF with heparan sulfate moieties on syndecan-1 strongly promotes HGF-mediated signaling, resulting in enhanced activation of Met, the receptor tyrosine kinase for HGF.	Heparitin Sulfate	41-56	hepatocyte growth factor	Homo sapiens	98-101
11830493-6	2002	Importantly, the interaction of HGF with heparan sulfate moieties on syndecan-1 strongly promotes HGF-mediated signaling, resulting in enhanced activation of Met, the receptor tyrosine kinase for HGF.	Heparitin Sulfate	41-56	hepatocyte growth factor	Homo sapiens	98-101
11793481-1	2002	MPS III results from a deficiency in one of the four enzymes involved in the degradation of heparan sulfate, with sulfamidase (SGSH) being deficient in MPS IIIA and a-N-acetylglucosaminidase (NAGLU) deficient in MPS IIIB.	Heparitin Sulfate	92-107	N-sulfoglucosamine sulfohydrolase	Homo sapiens	127-131
11829484-2	2002	The deficiency of SGSH results in the lysosomal accumulation and urinary excretion of the glycosaminoglycan heparan sulfate.	Heparitin Sulfate	108-123	N-sulfoglucosamine sulfohydrolase	Canis lupus familiaris	18-22
11793481-1	2002	MPS III results from a deficiency in one of the four enzymes involved in the degradation of heparan sulfate, with sulfamidase (SGSH) being deficient in MPS IIIA and a-N-acetylglucosaminidase (NAGLU) deficient in MPS IIIB.	Heparitin Sulfate	92-107	N-acetyl-alpha-glucosaminidase	Homo sapiens	165-190
11805315-0	2002	Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis.	Heparitin Sulfate	19-34	cripto, FRL-1, cryptic family 1	Homo sapiens	38-45
11723110-5	2002	The cell surface binding of MRP-14 was blocked by heparin, heparan sulfate, and chondroitin sulfate B, and the binding sites were sensitive to heparinase I and trypsin treatment but not to chondroitinase ABC.	Heparitin Sulfate	59-74	S100 calcium binding protein A9	Homo sapiens	28-34
11827992-1	2002	The murine VEGF gene is alternatively transcribed to yield the VEGF(120), VEGF(164), and VEGF(188) isoforms, which differ in their potential to bind to heparan sulfate and neuropilin-1 and to stimulate endothelial growth.	Heparitin Sulfate	152-167	vascular endothelial growth factor A	Mus musculus	11-15
11827992-1	2002	The murine VEGF gene is alternatively transcribed to yield the VEGF(120), VEGF(164), and VEGF(188) isoforms, which differ in their potential to bind to heparan sulfate and neuropilin-1 and to stimulate endothelial growth.	Heparitin Sulfate	152-167	vascular endothelial growth factor A	Mus musculus	63-67
11827992-1	2002	The murine VEGF gene is alternatively transcribed to yield the VEGF(120), VEGF(164), and VEGF(188) isoforms, which differ in their potential to bind to heparan sulfate and neuropilin-1 and to stimulate endothelial growth.	Heparitin Sulfate	152-167	vascular endothelial growth factor A	Mus musculus	63-67
11827992-1	2002	The murine VEGF gene is alternatively transcribed to yield the VEGF(120), VEGF(164), and VEGF(188) isoforms, which differ in their potential to bind to heparan sulfate and neuropilin-1 and to stimulate endothelial growth.	Heparitin Sulfate	152-167	vascular endothelial growth factor A	Mus musculus	63-67
11802174-4	2002	Here we show that perlecan, a multifunctional heparan sulfate proteoglycan concentrated at the NMJ, is the unique acceptor molecule for collagen-tailed AChE at sites of nerve-muscle contact and is the principal mechanism for localizing AChE to the synaptic basal lamina.	Heparitin Sulfate	46-61	acetylcholinesterase	Mus musculus	152-156
11779146-1	2002	Syndecan-1 is an integral membrane heparan sulfate/chondroitin sulfate proteoglycan, involved in the control of cell growth and differentiation.	Heparitin Sulfate	35-50	syndecan 1	Mus musculus	0-10
11706034-0	2002	Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients.	Heparitin Sulfate	0-15	noggin	Homo sapiens	37-43
11706034-7	2002	Noggin is detected only on the surface of cells that express heparan sulfate, can be specifically displaced from cells by heparin, and can be directly cross-linked to a cell surface proteoglycan in culture.	Heparitin Sulfate	61-76	noggin	Homo sapiens	0-6
11706034-8	2002	Heparan sulfate-bound Noggin remains functional and can bind BMP4 at the plasma membrane.	Heparitin Sulfate	0-15	noggin	Homo sapiens	22-28
11706034-8	2002	Heparan sulfate-bound Noggin remains functional and can bind BMP4 at the plasma membrane.	Heparitin Sulfate	0-15	bone morphogenetic protein 4	Homo sapiens	61-65
11779146-2	2002	The biological activities of syndecan-1 involve interactions with a variety of extracellular ligands, such as growth factors and matrix components, that are mainly mediated by the heparan sulfate moieties.	Heparitin Sulfate	180-195	syndecan 1	Mus musculus	29-39
12168569-4	2002	Antithrombin III stimulates prostacyclin generation in endothelial cells by interacting with heparan sulfate of endothelial cells and inhibits cytokine and tissue factor production in endothelial cells and monocytes.	Heparitin Sulfate	93-108	serpin family C member 1	Homo sapiens	0-16
11856307-6	2002	Recently, convincing biochemical and genetic findings has established that the full-length Tat protein was internalized in cells via the ubiquitous heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	148-163	tyrosine aminotransferase	Homo sapiens	91-94
11856307-6	2002	Recently, convincing biochemical and genetic findings has established that the full-length Tat protein was internalized in cells via the ubiquitous heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	165-167	tyrosine aminotransferase	Homo sapiens	91-94
11805133-1	2002	Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin rapidly in the presence of dermatan sulfate, heparan sulfate, or heparin.	Heparitin Sulfate	115-130	serine (or cysteine) peptidase inhibitor, clade D, member 1	Mus musculus	0-19
12463507-8	2002	FGF2 bound specifically to surface-adsorbed fibrinogen, fibronectin and vitronectin as well as to pre-coated heparan sulphate proteoglycan, perlecan.	Heparitin Sulfate	109-125	fibroblast growth factor 2	Homo sapiens	0-4
11805133-1	2002	Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin rapidly in the presence of dermatan sulfate, heparan sulfate, or heparin.	Heparitin Sulfate	115-130	serine (or cysteine) peptidase inhibitor, clade D, member 1	Mus musculus	21-25
11805133-1	2002	Heparin cofactor II (HCII) is a plasma protein that inhibits thrombin rapidly in the presence of dermatan sulfate, heparan sulfate, or heparin.	Heparitin Sulfate	115-130	coagulation factor II	Mus musculus	61-69
12032595-6	2002	EXT1 is expressed in the brain, and both EXT1 and EXT2 proteins are associated with glycosyltransferase activities required for the biosynthesis of heparan sulfate, which also has activity in the brain.	Heparitin Sulfate	148-163	exostosin glycosyltransferase 1	Homo sapiens	0-4
12032595-6	2002	EXT1 is expressed in the brain, and both EXT1 and EXT2 proteins are associated with glycosyltransferase activities required for the biosynthesis of heparan sulfate, which also has activity in the brain.	Heparitin Sulfate	148-163	exostosin glycosyltransferase 1	Homo sapiens	41-45
12032595-6	2002	EXT1 is expressed in the brain, and both EXT1 and EXT2 proteins are associated with glycosyltransferase activities required for the biosynthesis of heparan sulfate, which also has activity in the brain.	Heparitin Sulfate	148-163	exostosin glycosyltransferase 2	Homo sapiens	50-54
12471724-0	2002	Heparan sulfate (HS)/heparan sulfate proteoglycan (HSPG) and bikunin are up-regulated during calcium oxalate nephrolithiasis in rat kidney.	Heparitin Sulfate	0-15	syndecan 2	Rattus norvegicus	51-55
12658800-9	2002	The promotion of the heparan sulfate expression in bone marrow may be one of mechanisms of PF4.	Heparitin Sulfate	21-36	platelet factor 4	Mus musculus	91-94
12652971-1	2002	We have reported that heparan sulfate (HS)/heparan sulfate proteoglycan (HSPG, syndecan-1) expression significantly increased in the rat kidney during calcium oxalate (CaOx) nephrolithiasis.	Heparitin Sulfate	22-37	syndecan 1	Rattus norvegicus	73-77
12652971-1	2002	We have reported that heparan sulfate (HS)/heparan sulfate proteoglycan (HSPG, syndecan-1) expression significantly increased in the rat kidney during calcium oxalate (CaOx) nephrolithiasis.	Heparitin Sulfate	43-58	syndecan 1	Rattus norvegicus	73-77
11577085-0	2001	Modulations of glypican-1 heparan sulfate structure by inhibition of endogenous polyamine synthesis.	Heparitin Sulfate	26-41	glypican 1	Homo sapiens	15-25
11551958-7	2001	This product, Galbeta1,3Galbeta is found in the linkage region of heparan sulfate and chondroitin sulfate (GlcAbeta1,3Galbeta1,3Galbeta1,4Xylbeta-O-Ser), indicating that beta3GalT6 is the so-called galactosyltransferase II involved in glycosaminoglycan biosynthesis.	Heparitin Sulfate	66-81	beta-1,3-galactosyltransferase 6	Homo sapiens	170-180
11551958-7	2001	This product, Galbeta1,3Galbeta is found in the linkage region of heparan sulfate and chondroitin sulfate (GlcAbeta1,3Galbeta1,3Galbeta1,4Xylbeta-O-Ser), indicating that beta3GalT6 is the so-called galactosyltransferase II involved in glycosaminoglycan biosynthesis.	Heparitin Sulfate	66-81	beta-1,3-galactosyltransferase 6	Homo sapiens	198-222
11786226-5	2001	Lactoferrin-binding sites on the surface of HT29 cells were further identified as heparan sulphate and chondroitin sulphate glycosaminoglycans.	Heparitin Sulfate	82-98	lactotransferrin	Mus musculus	0-11
11784075-5	2001	Rather, evidence is presented suggesting that heparan sulfate moieties in extracellular matrix grafts bind an endogenous, extracellular factor involved in inhibition of anterior polarizing activity, leading to derepression of the anterior limb and induction of polarizing zone marker genes including Sonic hedgehog and Bone morphogenetic protein-2.	Heparitin Sulfate	46-61	bone morphogenetic protein 2	Mus musculus	319-347
12498227-3	2002	Total heparan sulphate (HS) was detected with a monoclonal antibody to HSPG on paraffin sections.	Heparitin Sulfate	6-22	syndecan 2	Homo sapiens	71-75
12498227-3	2002	Total heparan sulphate (HS) was detected with a monoclonal antibody to HSPG on paraffin sections.	Heparitin Sulfate	24-26	syndecan 2	Homo sapiens	71-75
12617788-9	2002	Heparan sulfate proteoglycan increases inner cell mass numbers and this may be due to interactions with the growth factors fibroblast growth factor 4 (FGF-4) and granulocyte-macrophage colony-stimulating factor.	Heparitin Sulfate	0-15	fibroblast growth factor 4	Mus musculus	123-149
12617788-9	2002	Heparan sulfate proteoglycan increases inner cell mass numbers and this may be due to interactions with the growth factors fibroblast growth factor 4 (FGF-4) and granulocyte-macrophage colony-stimulating factor.	Heparitin Sulfate	0-15	fibroblast growth factor 4	Mus musculus	151-156
12617788-9	2002	Heparan sulfate proteoglycan increases inner cell mass numbers and this may be due to interactions with the growth factors fibroblast growth factor 4 (FGF-4) and granulocyte-macrophage colony-stimulating factor.	Heparitin Sulfate	0-15	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	162-210
11755208-4	2001	These degradation products which were free heparan sulfate chains with little or no protein covalently attached, were approximately half the size of the original glycosaminoglycan chains and were the only degradation intermediate found in the course of HSPG catabolism in these cells.	Heparitin Sulfate	43-58	syndecan 2	Rattus norvegicus	253-257
11577085-10	2001	Here, we have analyzed the effect of polyamine deprivation on the structure and polyamine affinity of the heparan sulfate chains in various glypican-1 glycoforms synthesized by a transformed cell line (ECV 304).	Heparitin Sulfate	106-121	glypican 1	Homo sapiens	140-150
11577085-11	2001	Heparan sulfate chains of glypican-1 were either cleaved with heparanase at sites embracing the highly modified regions or with nitrite at N-unsubstituted glucosamine residues.	Heparitin Sulfate	0-15	glypican 1	Homo sapiens	26-36
11724555-10	2001	The results provide a structural basis to suggest that the unique FGF-7 heparin-binding (HB) domain underlies a specific restriction in respect to composition and length of the heparan sulfate motif that may impact specificity of localization, stability, and trafficking of FGF-7 in the microenvironment, and formation and activation of the FGFR2IIIb kinase signaling complex in epithelial cells.	Heparitin Sulfate	177-192	fibroblast growth factor 7	Homo sapiens	66-71
11724555-0	2001	Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.	Heparitin Sulfate	75-90	fibroblast growth factor 1	Homo sapiens	36-41
11724555-10	2001	The results provide a structural basis to suggest that the unique FGF-7 heparin-binding (HB) domain underlies a specific restriction in respect to composition and length of the heparan sulfate motif that may impact specificity of localization, stability, and trafficking of FGF-7 in the microenvironment, and formation and activation of the FGFR2IIIb kinase signaling complex in epithelial cells.	Heparitin Sulfate	177-192	fibroblast growth factor 7	Homo sapiens	274-279
11724555-0	2001	Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.	Heparitin Sulfate	75-90	fibroblast growth factor 2	Homo sapiens	43-48
11724555-0	2001	Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.	Heparitin Sulfate	75-90	fibroblast growth factor 7	Homo sapiens	54-59
11751503-0	2001	Heparan sulfate enhances invasion by human colon carcinoma cell lines through expression of CD44 variant exon 3.	Heparitin Sulfate	0-15	CD44 molecule (Indian blood group)	Homo sapiens	92-96
11751503-1	2001	CD44 variant exon (CD44v) 3 is a heparan sulfate-binding isoform of CD44.	Heparitin Sulfate	33-48	CD44 molecule (Indian blood group)	Homo sapiens	0-4
11751503-1	2001	CD44 variant exon (CD44v) 3 is a heparan sulfate-binding isoform of CD44.	Heparitin Sulfate	33-48	CD44 molecule (Indian blood group)	Homo sapiens	19-23
11751503-8	2001	In heparan sulfate-treated Colo320 cells, the levels of CD44v3 protein in the Triton X-100-insoluble fraction and moesin-precipitated fraction were increased, suggesting that heparan sulfate treatment facilitates association of CD44 molecules with the cytoskeleton.	Heparitin Sulfate	3-18	CD44 molecule (Indian blood group)	Homo sapiens	56-60
11751503-8	2001	In heparan sulfate-treated Colo320 cells, the levels of CD44v3 protein in the Triton X-100-insoluble fraction and moesin-precipitated fraction were increased, suggesting that heparan sulfate treatment facilitates association of CD44 molecules with the cytoskeleton.	Heparitin Sulfate	175-190	CD44 molecule (Indian blood group)	Homo sapiens	56-60
11553626-10	2001	By contrast, the homology of Ym1 and Ym2 to proteins associated with tissue remodeling, together with the previous findings that Ym1 is homologous to chitinase and binds heparin sulfate and GlcN oligomers (chitobiose, chitotriose, and chitotetraose), strongly suggests these proteins play an important role in airway wall remodeling in the allergic lung.	Heparitin Sulfate	170-185	chitinase-like 4	Mus musculus	37-40
11724824-0	2001	Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition.	Heparitin Sulfate	8-23	fibroblast growth factor 4	Mus musculus	58-63
11551944-0	2001	Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: evidence in support of the "cooperative end structures" model.	Heparitin Sulfate	9-24	fibroblast growth factor 2	Homo sapiens	48-52
11551944-0	2001	Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: evidence in support of the "cooperative end structures" model.	Heparitin Sulfate	9-24	fibroblast growth factor receptor 1	Homo sapiens	53-58
11551944-1	2001	Fibroblast growth factor 2 (FGF2)-initiated FGF receptor (FGFR)-signaling requires the assistance of heparin/heparan sulfate.	Heparitin Sulfate	109-124	fibroblast growth factor 2	Homo sapiens	0-26
11551944-1	2001	Fibroblast growth factor 2 (FGF2)-initiated FGF receptor (FGFR)-signaling requires the assistance of heparin/heparan sulfate.	Heparitin Sulfate	109-124	fibroblast growth factor 2	Homo sapiens	28-32
11551944-2	2001	Here, we evaluated the effects of different heparan sulfate proteoglycan (HSPG)-expressing cell lines and HSPGs derived from these cells on FGF2-induced FGFR1-phosphorylation in heparan sulfate-negative BaF3 cells.	Heparitin Sulfate	44-59	fibroblast growth factor 2	Mus musculus	140-144
11689640-0	2001	Cell surface heparan sulfate is a receptor for human herpesvirus 8 and interacts with envelope glycoprotein K8.1.	Heparitin Sulfate	13-28	K8.1	Human gammaherpesvirus 8	86-107
11689640-0	2001	Cell surface heparan sulfate is a receptor for human herpesvirus 8 and interacts with envelope glycoprotein K8.1.	Heparitin Sulfate	13-28	K8.1	Human gammaherpesvirus 8	108-112
11689640-8	2001	This revealed that K8.1 binds to heparin with an affinity comparable to that of glycoproteins B and C of herpes simplex virus, which are known to be involved in target cell recognition by binding to cell surface proteoglycans, especially heparan sulfate.	Heparitin Sulfate	238-253	keratin 81	Homo sapiens	19-23
11551944-2	2001	Here, we evaluated the effects of different heparan sulfate proteoglycan (HSPG)-expressing cell lines and HSPGs derived from these cells on FGF2-induced FGFR1-phosphorylation in heparan sulfate-negative BaF3 cells.	Heparitin Sulfate	44-59	fibroblast growth factor receptor 1	Mus musculus	153-158
11553626-10	2001	By contrast, the homology of Ym1 and Ym2 to proteins associated with tissue remodeling, together with the previous findings that Ym1 is homologous to chitinase and binds heparin sulfate and GlcN oligomers (chitobiose, chitotriose, and chitotetraose), strongly suggests these proteins play an important role in airway wall remodeling in the allergic lung.	Heparitin Sulfate	170-185	chitinase-like 3	Mus musculus	129-132
11691803-2	2001	Heparanase is an endoglucuronidase capable of specifically degrading heparan sulfate, and its activity is associated with the metastatic potential of tumor cells.	Heparitin Sulfate	69-84	heparanase	Homo sapiens	0-10
11687650-0	2001	Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo.	Heparitin Sulfate	23-38	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	78-98
11784020-8	2001	Inhibition of HSPG sulfation by treatment of intact myofibers with chlorate results in delayed proliferation and altered MyoD expression, demonstrating that heparan sulfate is required for proper progression of the early satellite cell myogenic program.	Heparitin Sulfate	157-172	myogenic differentiation 1	Homo sapiens	121-125
11878776-1	2001	BACKGROUND: Glypican-3 (GPC3) is a heparan sulfate proteoglycan.	Heparitin Sulfate	35-50	glypican 3	Homo sapiens	12-22
11735025-1	2001	The lysosomal storage disorder, mucopolysaccharidosis type I (MPS I), is caused by a deficiency of the enzyme alpha-L-iduronidase, which is involved in the breakdown of dermatan and heparan sulphates.	Heparitin Sulfate	182-199	alpha-L-iduronidase	Homo sapiens	110-129
11878776-1	2001	BACKGROUND: Glypican-3 (GPC3) is a heparan sulfate proteoglycan.	Heparitin Sulfate	35-50	glypican 3	Homo sapiens	24-28
11597998-1	2001	NK1 is a splice variant of the polypeptide growth factor HGF/SF, which consists of the N-terminal (N) and first kringle (K) domain and requires heparan sulfate or soluble heparin for activity.	Heparitin Sulfate	144-159	tachykinin receptor 1	Homo sapiens	0-3
11500500-1	2001	Defective binding of apolipoprotein E (apoE) to heparan sulfate proteoglycans (HSPGs) is associated with increased risk of atherosclerosis due to inefficient clearance of lipoprotein remnants by the liver.	Heparitin Sulfate	48-63	apolipoprotein E	Homo sapiens	21-37
11500500-1	2001	Defective binding of apolipoprotein E (apoE) to heparan sulfate proteoglycans (HSPGs) is associated with increased risk of atherosclerosis due to inefficient clearance of lipoprotein remnants by the liver.	Heparitin Sulfate	48-63	apolipoprotein E	Homo sapiens	39-43
11500500-8	2001	This model indicates that apoE has an HSPG-binding site highly complementary to heparan sulfate rich in N- and O-sulfo groups such as that found in the liver and the brain.	Heparitin Sulfate	80-95	apolipoprotein E	Homo sapiens	26-30
11509569-5	2001	We show that recombinant FGF-BP1 specifically binds FGF-2 and that this binding is inhibited by FGF-1, heparan sulfate, and heparinoids.	Heparitin Sulfate	103-118	fibroblast growth factor binding protein 1	Homo sapiens	25-32
11509569-5	2001	We show that recombinant FGF-BP1 specifically binds FGF-2 and that this binding is inhibited by FGF-1, heparan sulfate, and heparinoids.	Heparitin Sulfate	103-118	fibroblast growth factor 2	Homo sapiens	52-57
11597998-1	2001	NK1 is a splice variant of the polypeptide growth factor HGF/SF, which consists of the N-terminal (N) and first kringle (K) domain and requires heparan sulfate or soluble heparin for activity.	Heparitin Sulfate	144-159	hepatocyte growth factor	Homo sapiens	57-63
11597998-7	2001	We exploit the interaction between heparin and the K domain site in order to engineer NK1 as a potent receptor agonist and suggest that dual (positive and negative) control may be a general mechanism of heparan sulfate-dependent regulation of growth factor activity.	Heparitin Sulfate	203-218	tachykinin receptor 1	Homo sapiens	86-89
11559927-6	2001	HS is the major GAG in the cell membrane of THP-1.	Heparitin Sulfate	0-2	GLI family zinc finger 2	Homo sapiens	44-49
11557552-4	2001	The expression and secretion of EC-SOD were upregulated by histamine, vasopressin, oxytocin, endothelin-1, angiotensin II, serotonin, heparin, and heparan sulfate and were downregulated by platelet-derived growth factors-AA and -BB, acidic and basic fibroblast growth factors, and epidermal growth factor.	Heparitin Sulfate	147-162	superoxide dismutase 3	Homo sapiens	32-38
11566193-1	2001	Extracellular-superoxide dismutase (EC-SOD) is bound to the vascular endothelial cell surface with an affinity for heparan sulfate proteoglycan.	Heparitin Sulfate	115-130	superoxide dismutase 3	Homo sapiens	0-34
11563979-1	2001	Perlecan, a widespread heparan sulphate (HS) proteoglycan, is directly involved in the storing of angiogenic growth factors, mostly members of the fibroblast growth factor (FGF) gene family.	Heparitin Sulfate	23-39	fibroblast growth factor 7	Homo sapiens	173-176
11563979-1	2001	Perlecan, a widespread heparan sulphate (HS) proteoglycan, is directly involved in the storing of angiogenic growth factors, mostly members of the fibroblast growth factor (FGF) gene family.	Heparitin Sulfate	41-43	fibroblast growth factor 7	Homo sapiens	173-176
11568003-0	2001	Sperm protein 17 is expressed on normal and malignant lymphocytes and promotes heparan sulfate-mediated cell-cell adhesion.	Heparitin Sulfate	79-94	sperm autoantigenic protein 17	Homo sapiens	0-16
11568003-6	2001	The rSp17 binds to the surface of myeloma cells but not to cells pretreated with heparitinase, an enzyme that removes heparan sulfate from the cell surface.	Heparitin Sulfate	118-133	sperm autoantigenic protein 17	Rattus norvegicus	4-9
11568003-8	2001	These findings suggest that Sp17 promotes heparan sulfate-mediated cell aggregation and thereby plays a role in regulating adhesion and migration of normal and malignant lymphocytes.	Heparitin Sulfate	42-57	sperm autoantigenic protein 17	Homo sapiens	28-32
11560500-6	2001	The decasaccharide has a structure commonly found in hepatic heparan sulfate, and the same sequence has recently been shown to bind specifically to apolipoprotein E.	Heparitin Sulfate	61-76	apolipoprotein E	Homo sapiens	148-164
11461921-0	2001	Interactions of fibrillin-1 with heparin/heparan sulfate, implications for microfibrillar assembly.	Heparitin Sulfate	41-56	fibrillin 1	Homo sapiens	16-27
11461921-2	2001	Here we identify, characterize, and localize heparin/heparan sulfate-binding sites in fibrillin-1 and report on the role of such glycosaminoglycans in the assembly of fibrillin-1.	Heparitin Sulfate	53-68	fibrillin 1	Homo sapiens	86-97
11461921-2	2001	Here we identify, characterize, and localize heparin/heparan sulfate-binding sites in fibrillin-1 and report on the role of such glycosaminoglycans in the assembly of fibrillin-1.	Heparitin Sulfate	53-68	fibrillin 1	Homo sapiens	167-178
11461921-6	2001	When heparin or heparan sulfate was added to cultures of skin fibroblasts, the assembly of fibrillin-1 into a microfibrillar network was significantly reduced.	Heparitin Sulfate	16-31	fibrillin 1	Homo sapiens	91-102
11461921-9	2001	These studies suggest that binding of fibrillin-1 to proteoglycan-associated heparan sulfate chains is an important step in the assembly of microfibrils.	Heparitin Sulfate	77-92	fibrillin 1	Homo sapiens	38-49
11563988-2	2001	Individual isoforms of heparan sulphate D-glucosaminyl 3-O-sulphotransferase (3-OST) exhibit sequence-specific action, which creates heparan sulphate structures with distinct biological functions.	Heparitin Sulfate	23-39	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	55-76
11563988-2	2001	Individual isoforms of heparan sulphate D-glucosaminyl 3-O-sulphotransferase (3-OST) exhibit sequence-specific action, which creates heparan sulphate structures with distinct biological functions.	Heparitin Sulfate	23-39	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	78-83
11710433-0	2001	Directional specificity of prostate stromal to epithelial cell communication via FGF7/FGFR2 is set by cell- and FGFR2 isoform-specific heparan sulfate.	Heparitin Sulfate	135-150	fibroblast growth factor 7	Homo sapiens	81-85
11710433-0	2001	Directional specificity of prostate stromal to epithelial cell communication via FGF7/FGFR2 is set by cell- and FGFR2 isoform-specific heparan sulfate.	Heparitin Sulfate	135-150	fibroblast growth factor receptor 2	Homo sapiens	86-91
11710433-0	2001	Directional specificity of prostate stromal to epithelial cell communication via FGF7/FGFR2 is set by cell- and FGFR2 isoform-specific heparan sulfate.	Heparitin Sulfate	135-150	fibroblast growth factor receptor 2	Homo sapiens	112-117
11457822-0	2001	The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse.	Heparitin Sulfate	27-42	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	50-55
11566193-1	2001	Extracellular-superoxide dismutase (EC-SOD) is bound to the vascular endothelial cell surface with an affinity for heparan sulfate proteoglycan.	Heparitin Sulfate	115-130	superoxide dismutase 3	Homo sapiens	36-42
11518516-1	2001	In the present study, the role of a member of the epidermal growth factor (EGF) family, heparin-binding EGF-like growth factor (HB-EGF), in organ development was investigated by using developing mouse submandibular gland (SMG), in which the EGF receptor signaling and heparan sulfate chains have been implicated.	Heparitin Sulfate	268-283	heparin-binding EGF-like growth factor	Mus musculus	88-126
11518516-1	2001	In the present study, the role of a member of the epidermal growth factor (EGF) family, heparin-binding EGF-like growth factor (HB-EGF), in organ development was investigated by using developing mouse submandibular gland (SMG), in which the EGF receptor signaling and heparan sulfate chains have been implicated.	Heparitin Sulfate	268-283	heparin-binding EGF-like growth factor	Mus musculus	128-134
11522680-8	2001	The effects of insulin or linoleic acid on syndecan 1, a cell surface HS PG, were similar to those on versican, but less pronounced.	Heparitin Sulfate	70-72	insulin	Homo sapiens	15-22
11435444-1	2001	Hepatocyte growth factor (HGF) is a secreted, heparan sulfate (HS) glycosaminoglycan-binding protein that stimulates mitogenesis, motogenesis, and morphogenesis in a wide array of cellular targets, including hepatocytes and other epithelial cells, melanocytes, endothelial cells, and hematopoietic cells.	Heparitin Sulfate	63-65	hepatocyte growth factor	Homo sapiens	26-29
11522680-8	2001	The effects of insulin or linoleic acid on syndecan 1, a cell surface HS PG, were similar to those on versican, but less pronounced.	Heparitin Sulfate	70-72	syndecan 1	Homo sapiens	43-53
11533660-0	2001	Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events.	Heparitin Sulfate	48-64	fringe connection	Drosophila melanogaster	17-34
11558154-4	2001	In the presence of TPO, adding of HA-p or HS (100 micrograms/ml) resulted in an approximately 1.3-fold increase, in the total number of colonies, due to an increase in large megakaryocyte colonies.	Heparitin Sulfate	42-44	thrombopoietin	Homo sapiens	19-22
11435444-0	2001	Dissociation of heparan sulfate and receptor binding domains of hepatocyte growth factor reveals that heparan sulfate-c-met interaction facilitates signaling.	Heparitin Sulfate	16-31	hepatocyte growth factor	Homo sapiens	64-88
11435444-0	2001	Dissociation of heparan sulfate and receptor binding domains of hepatocyte growth factor reveals that heparan sulfate-c-met interaction facilitates signaling.	Heparitin Sulfate	16-31	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	118-123
11435444-0	2001	Dissociation of heparan sulfate and receptor binding domains of hepatocyte growth factor reveals that heparan sulfate-c-met interaction facilitates signaling.	Heparitin Sulfate	102-117	hepatocyte growth factor	Homo sapiens	64-88
11435444-0	2001	Dissociation of heparan sulfate and receptor binding domains of hepatocyte growth factor reveals that heparan sulfate-c-met interaction facilitates signaling.	Heparitin Sulfate	102-117	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	118-123
11435444-1	2001	Hepatocyte growth factor (HGF) is a secreted, heparan sulfate (HS) glycosaminoglycan-binding protein that stimulates mitogenesis, motogenesis, and morphogenesis in a wide array of cellular targets, including hepatocytes and other epithelial cells, melanocytes, endothelial cells, and hematopoietic cells.	Heparitin Sulfate	46-61	hepatocyte growth factor	Homo sapiens	0-24
11435444-1	2001	Hepatocyte growth factor (HGF) is a secreted, heparan sulfate (HS) glycosaminoglycan-binding protein that stimulates mitogenesis, motogenesis, and morphogenesis in a wide array of cellular targets, including hepatocytes and other epithelial cells, melanocytes, endothelial cells, and hematopoietic cells.	Heparitin Sulfate	46-61	hepatocyte growth factor	Homo sapiens	26-29
11435444-1	2001	Hepatocyte growth factor (HGF) is a secreted, heparan sulfate (HS) glycosaminoglycan-binding protein that stimulates mitogenesis, motogenesis, and morphogenesis in a wide array of cellular targets, including hepatocytes and other epithelial cells, melanocytes, endothelial cells, and hematopoietic cells.	Heparitin Sulfate	63-65	hepatocyte growth factor	Homo sapiens	0-24
11533493-4	2001	The jekyll mutation disrupts a homolog of Drosophila Sugarless, a uridine 5"-diphosphate (UDP)-glucose dehydrogenase required for heparan sulfate, chondroitin sulfate, and hyaluronic acid production.	Heparitin Sulfate	130-145	sugarless	Drosophila melanogaster	53-62
11558154-9	2001	These results suggest that HA-p and HS promote the proliferation of immature CB CD34+ CFU-Meg in the presence of TPO.	Heparitin Sulfate	36-38	CD34 molecule	Homo sapiens	80-84
11558154-9	2001	These results suggest that HA-p and HS promote the proliferation of immature CB CD34+ CFU-Meg in the presence of TPO.	Heparitin Sulfate	36-38	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	90-93
11558154-9	2001	These results suggest that HA-p and HS promote the proliferation of immature CB CD34+ CFU-Meg in the presence of TPO.	Heparitin Sulfate	36-38	thrombopoietin	Homo sapiens	113-116
11384972-2	2001	Syndecan-1, present on the surfaces of normal murine mammary gland epithelial cells, is a transmembrane hybrid proteoglycan, which bears glycosaminoglycan (GAG) side chains of heparan sulfate (HS) and chondroitin sulfate (CS).	Heparitin Sulfate	176-191	syndecan 1	Mus musculus	0-10
11406624-0	2001	Sequence analysis of heparan sulfate epitopes with graded affinities for fibroblast growth factors 1 and 2.	Heparitin Sulfate	21-36	fibroblast growth factor 1	Homo sapiens	73-106
11406624-2	2001	Several FGFs, including the prototype factors FGF-1 and FGF-2, depend on interactions with heparan sulfate (HS) proteoglycans for activity.	Heparitin Sulfate	91-106	fibroblast growth factor 1	Homo sapiens	46-51
11406624-2	2001	Several FGFs, including the prototype factors FGF-1 and FGF-2, depend on interactions with heparan sulfate (HS) proteoglycans for activity.	Heparitin Sulfate	91-106	fibroblast growth factor 2	Homo sapiens	56-61
11406624-2	2001	Several FGFs, including the prototype factors FGF-1 and FGF-2, depend on interactions with heparan sulfate (HS) proteoglycans for activity.	Heparitin Sulfate	108-110	fibroblast growth factor 1	Homo sapiens	46-51
11406624-2	2001	Several FGFs, including the prototype factors FGF-1 and FGF-2, depend on interactions with heparan sulfate (HS) proteoglycans for activity.	Heparitin Sulfate	108-110	fibroblast growth factor 2	Homo sapiens	56-61
11375980-1	2001	We have demonstrated previously that the Slit proteins, which are involved in axonal guidance and related developmental processes in nervous tissue, are ligands of the glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan glypican-1 in brain (Liang, Y., Annan, R. S., Carr, S. A., Popp, S., Mevissen, M., Margolis, R. K., and Margolis, R. U.	Heparitin Sulfate	206-221	glypican 1	Homo sapiens	235-245
11375980-1	2001	We have demonstrated previously that the Slit proteins, which are involved in axonal guidance and related developmental processes in nervous tissue, are ligands of the glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan glypican-1 in brain (Liang, Y., Annan, R. S., Carr, S. A., Popp, S., Mevissen, M., Margolis, R. K., and Margolis, R. U.	Heparitin Sulfate	206-221	arrestin 3	Homo sapiens	281-285
11384972-2	2001	Syndecan-1, present on the surfaces of normal murine mammary gland epithelial cells, is a transmembrane hybrid proteoglycan, which bears glycosaminoglycan (GAG) side chains of heparan sulfate (HS) and chondroitin sulfate (CS).	Heparitin Sulfate	193-195	syndecan 1	Mus musculus	0-10
11463336-13	2001	We predict that two of the three missense mutants increase the binding of anosmin-1 to an extracellular target, possibly by enhancing heparan sulphate binding, and that this critically affects the function of anosmin-1.	Heparitin Sulfate	134-150	anosmin 1	Homo sapiens	74-83
11509012-1	2001	Mucopolysaccharidosis type IIIA (MPS-IIIA) is an autosomal recessive lysosomal storage disorder caused by the deficiency of heparan-N-sulfamidase (NS; EC 3.10.1.1), resulting in defective degradation and subsequent storage of heparan sulfate and leading to a clinical phenotype known as Sanfilippo syndrome.	Heparitin Sulfate	226-241	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-31
11461073-3	2001	Among them, EXT1 and EXT2, which encode enzymes that catalyse the biosynthesis of heparan sulfate, an important component of the extracellular matrix, are responsible for over 70% of the EXT cases.	Heparitin Sulfate	82-97	exostosin glycosyltransferase 1	Homo sapiens	12-16
11522012-7	2001	The release of these proteins from cells within the necrotic core of a tumour or from cells killed during chemotherapy may abrogate the heparan sulphate/antithrombin system and possibly contribute to the idiopathic thromboembolism often associated with cancer (Trousseau"s syndrome).	Heparitin Sulfate	136-152	serpin family C member 1	Homo sapiens	153-165
12940068-8	2001	CONCLUSIONS: ApoE associates with the cell surface mainly through chondrointin sulfate proteoglycans and to a lesser extent through heparan sulfate proteoglycans, decreased levels of cell surface apoE increase the binding of LDL to the cell surface.	Heparitin Sulfate	132-147	apolipoprotein E	Homo sapiens	13-17
12940068-8	2001	CONCLUSIONS: ApoE associates with the cell surface mainly through chondrointin sulfate proteoglycans and to a lesser extent through heparan sulfate proteoglycans, decreased levels of cell surface apoE increase the binding of LDL to the cell surface.	Heparitin Sulfate	132-147	apolipoprotein E	Homo sapiens	196-200
11461073-3	2001	Among them, EXT1 and EXT2, which encode enzymes that catalyse the biosynthesis of heparan sulfate, an important component of the extracellular matrix, are responsible for over 70% of the EXT cases.	Heparitin Sulfate	82-97	exostosin glycosyltransferase 2	Homo sapiens	21-25
11461073-3	2001	Among them, EXT1 and EXT2, which encode enzymes that catalyse the biosynthesis of heparan sulfate, an important component of the extracellular matrix, are responsible for over 70% of the EXT cases.	Heparitin Sulfate	82-97	exostosin glycosyltransferase 1	Homo sapiens	12-15
11437449-3	2001	Earlier studies have shown that Dally, an integral membrane, heparan sulfate-modified proteoglycan, affects both Wg and Dpp signaling in a tissue-specific manner.	Heparitin Sulfate	61-76	decapentaplegic	Drosophila melanogaster	120-123
11391482-2	2001	The corresponding gene products, exostosin-1 (EXT1) and exostosin-2 (EXT2), are type II transmembrane glycoproteins which form a Golgi-localized heterooligomeric complex that catalyzes the polymerization of heparan sulfate (HS).	Heparitin Sulfate	207-222	exostosin glycosyltransferase 1	Homo sapiens	33-44
11437376-9	2001	In subendothelial space, EC-SOD bound on heparan sulfate might suppress LDL oxidation through reduction of superoxide anion.	Heparitin Sulfate	41-56	superoxide dismutase 3	Homo sapiens	25-31
11391482-2	2001	The corresponding gene products, exostosin-1 (EXT1) and exostosin-2 (EXT2), are type II transmembrane glycoproteins which form a Golgi-localized heterooligomeric complex that catalyzes the polymerization of heparan sulfate (HS).	Heparitin Sulfate	207-222	exostosin glycosyltransferase 1	Homo sapiens	46-50
11391482-2	2001	The corresponding gene products, exostosin-1 (EXT1) and exostosin-2 (EXT2), are type II transmembrane glycoproteins which form a Golgi-localized heterooligomeric complex that catalyzes the polymerization of heparan sulfate (HS).	Heparitin Sulfate	207-222	exostosin glycosyltransferase 2	Homo sapiens	56-67
11391482-2	2001	The corresponding gene products, exostosin-1 (EXT1) and exostosin-2 (EXT2), are type II transmembrane glycoproteins which form a Golgi-localized heterooligomeric complex that catalyzes the polymerization of heparan sulfate (HS).	Heparitin Sulfate	207-222	exostosin glycosyltransferase 2	Homo sapiens	69-73
11391482-2	2001	The corresponding gene products, exostosin-1 (EXT1) and exostosin-2 (EXT2), are type II transmembrane glycoproteins which form a Golgi-localized heterooligomeric complex that catalyzes the polymerization of heparan sulfate (HS).	Heparitin Sulfate	224-226	exostosin glycosyltransferase 1	Homo sapiens	33-44
11391482-2	2001	The corresponding gene products, exostosin-1 (EXT1) and exostosin-2 (EXT2), are type II transmembrane glycoproteins which form a Golgi-localized heterooligomeric complex that catalyzes the polymerization of heparan sulfate (HS).	Heparitin Sulfate	224-226	exostosin glycosyltransferase 1	Homo sapiens	46-50
11391482-2	2001	The corresponding gene products, exostosin-1 (EXT1) and exostosin-2 (EXT2), are type II transmembrane glycoproteins which form a Golgi-localized heterooligomeric complex that catalyzes the polymerization of heparan sulfate (HS).	Heparitin Sulfate	224-226	exostosin glycosyltransferase 2	Homo sapiens	56-67
11391482-2	2001	The corresponding gene products, exostosin-1 (EXT1) and exostosin-2 (EXT2), are type II transmembrane glycoproteins which form a Golgi-localized heterooligomeric complex that catalyzes the polymerization of heparan sulfate (HS).	Heparitin Sulfate	224-226	exostosin glycosyltransferase 2	Homo sapiens	69-73
11391482-6	2001	Here, a functional assay that detects HS expression on the cell surface of an EXT1-deficient cell line was used to test the remaining missense mutant exostosin proteins for their ability to rescue HS biosynthesis in vivo.	Heparitin Sulfate	38-40	exostosin glycosyltransferase 1	Homo sapiens	78-82
11676284-8	2001	Immunocytochemistry has demonstrated that even with this rapid progression, Abeta deposits within the neuropil and cerebrovascular system all co-localize with heparan sulfate proteoglycans (HSPG).	Heparitin Sulfate	159-174	amyloid beta (A4) precursor protein	Mus musculus	76-81
11676284-8	2001	Immunocytochemistry has demonstrated that even with this rapid progression, Abeta deposits within the neuropil and cerebrovascular system all co-localize with heparan sulfate proteoglycans (HSPG).	Heparitin Sulfate	159-174	syndecan 2	Mus musculus	190-194
11438211-14	2001	We postulate that the presence of highly sulfated domains in the HS chains from BMEC contributes to tissue specificity of bone marrow endothelium in which HS may be involved in SDF-1 presentation and adhesion of hematopoietic progenitor cells.	Heparitin Sulfate	65-67	C-X-C motif chemokine ligand 12	Homo sapiens	177-182
11415432-2	2001	Several recent reports have implicated Sp17 as having a role in cell-cell adhesion and/or cell migration in transformed, lymphocytic and haematopoietic cells, possibly through its interaction with extracellular heparan sulphate.	Heparitin Sulfate	211-227	sperm autoantigenic protein 17	Mus musculus	39-43
11449373-0	2001	IgM and stromal cell-associated heparan sulfate/heparin as complement-independent ligands for CD19.	Heparitin Sulfate	32-47	CD19 antigen	Mus musculus	94-98
11438211-14	2001	We postulate that the presence of highly sulfated domains in the HS chains from BMEC contributes to tissue specificity of bone marrow endothelium in which HS may be involved in SDF-1 presentation and adhesion of hematopoietic progenitor cells.	Heparitin Sulfate	155-157	C-X-C motif chemokine ligand 12	Homo sapiens	177-182
11451357-9	2001	Sperm chromatin decondensation following exposure to heparin sulfate was significantly increased in patients without a measurable P2 band.	Heparitin Sulfate	53-68	protamine 2	Homo sapiens	130-132
11316800-8	2001	The heparin-binding site of APC was also shown to interact with heparan sulfate, albeit with lower affinity.	Heparitin Sulfate	64-79	APC regulator of WNT signaling pathway	Homo sapiens	28-31
11382923-0	2001	Perlecan inhibits smooth muscle cell adhesion to fibronectin: role of heparan sulfate.	Heparitin Sulfate	70-85	heparan sulfate proteoglycan 2	Rattus norvegicus	0-8
11382923-6	2001	Furthermore, heparan sulfate as well as heparin reduced smooth muscle cell adhesion when combined with fibronectin whereas neither hyaluronan nor chondroitin sulfate had any anti-adhesive effects.	Heparitin Sulfate	13-28	fibronectin 1	Rattus norvegicus	103-114
11382923-11	2001	The results show that the heparan sulfate chains of perlecan lead to altered interactions between smooth muscle cells and fibronectin, possibly due to conformational changes in the fibronectin molecule.	Heparitin Sulfate	26-41	heparan sulfate proteoglycan 2	Rattus norvegicus	52-60
11382923-11	2001	The results show that the heparan sulfate chains of perlecan lead to altered interactions between smooth muscle cells and fibronectin, possibly due to conformational changes in the fibronectin molecule.	Heparitin Sulfate	26-41	fibronectin 1	Rattus norvegicus	122-133
11382923-11	2001	The results show that the heparan sulfate chains of perlecan lead to altered interactions between smooth muscle cells and fibronectin, possibly due to conformational changes in the fibronectin molecule.	Heparitin Sulfate	26-41	fibronectin 1	Rattus norvegicus	181-192
11432960-3	2001	The EXT1 and EXT2 genes encode glycosyltransferases involved in biosynthesis of heparan sulphate proteoglycans.	Heparitin Sulfate	80-96	exostosin glycosyltransferase 1	Homo sapiens	4-8
11432960-3	2001	The EXT1 and EXT2 genes encode glycosyltransferases involved in biosynthesis of heparan sulphate proteoglycans.	Heparitin Sulfate	80-96	exostosin glycosyltransferase 2	Homo sapiens	13-17
11292822-2	2001	In the case of fibroblast growth factor-2 (FGF2) signaling, heparin/heparan sulfate-like glycosaminoglycans (HLGAGs) are involved through interaction with both FGF2 and its receptors (FGFRs) in assembling a tertiary complex and modulating FGF2 activity.	Heparitin Sulfate	68-83	fibroblast growth factor 2	Homo sapiens	15-41
11292822-2	2001	In the case of fibroblast growth factor-2 (FGF2) signaling, heparin/heparan sulfate-like glycosaminoglycans (HLGAGs) are involved through interaction with both FGF2 and its receptors (FGFRs) in assembling a tertiary complex and modulating FGF2 activity.	Heparitin Sulfate	68-83	fibroblast growth factor 2	Homo sapiens	43-47
11292822-2	2001	In the case of fibroblast growth factor-2 (FGF2) signaling, heparin/heparan sulfate-like glycosaminoglycans (HLGAGs) are involved through interaction with both FGF2 and its receptors (FGFRs) in assembling a tertiary complex and modulating FGF2 activity.	Heparitin Sulfate	68-83	fibroblast growth factor 2	Homo sapiens	160-164
11292822-2	2001	In the case of fibroblast growth factor-2 (FGF2) signaling, heparin/heparan sulfate-like glycosaminoglycans (HLGAGs) are involved through interaction with both FGF2 and its receptors (FGFRs) in assembling a tertiary complex and modulating FGF2 activity.	Heparitin Sulfate	68-83	fibroblast growth factor 2	Homo sapiens	160-164
11426225-0	2001	Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein.	Heparitin Sulfate	13-28	slit guidance ligand 2	Homo sapiens	81-86
11426225-2	2001	Here it was shown that Slit2-Robo-1 interactions were enhanced by cell-surface heparan sulfate.	Heparitin Sulfate	79-94	slit guidance ligand 2	Homo sapiens	23-28
11426225-2	2001	Here it was shown that Slit2-Robo-1 interactions were enhanced by cell-surface heparan sulfate.	Heparitin Sulfate	79-94	roundabout guidance receptor 1	Homo sapiens	29-35
11426225-3	2001	Removal of heparan sulfate decreased the affinity of Slit for Robo by about threefold.	Heparitin Sulfate	11-26	roundabout guidance receptor 1	Homo sapiens	62-66
11426225-4	2001	In addition, removal of cell-surface heparan sulfate by heparinase III abolished the chemorepulsive response to Slit2 normally shown by both the migrating neurons and growing axons.	Heparitin Sulfate	37-52	slit guidance ligand 2	Homo sapiens	112-117
11426225-5	2001	These results indicate essential roles for cell-surface heparan sulfate in the repulsive activities of Slit2.	Heparitin Sulfate	56-71	slit guidance ligand 2	Homo sapiens	103-108
11679141-5	2001	These heparan sulfates exhibited a predominant inhibitory effect on fibroblast growth factor-2 binding to fibroblast growth factor receptor-1, when tested in cells deficient in cell surface heparan sulfates.	Heparitin Sulfate	6-22	fibroblast growth factor 2	Homo sapiens	68-94
11679141-5	2001	These heparan sulfates exhibited a predominant inhibitory effect on fibroblast growth factor-2 binding to fibroblast growth factor receptor-1, when tested in cells deficient in cell surface heparan sulfates.	Heparitin Sulfate	6-22	fibroblast growth factor receptor 1	Homo sapiens	106-141
11679141-5	2001	These heparan sulfates exhibited a predominant inhibitory effect on fibroblast growth factor-2 binding to fibroblast growth factor receptor-1, when tested in cells deficient in cell surface heparan sulfates.	Heparitin Sulfate	190-206	fibroblast growth factor receptor 1	Homo sapiens	106-141
11679141-6	2001	During wound healing, there was a marked decrease in the relative inhibitory activity of the extracted heparan sulfates on fibroblast growth factor-2-receptor binding.	Heparitin Sulfate	103-119	fibroblast growth factor 2	Homo sapiens	123-149
11316800-9	2001	In conclusion, we have characterized and spatially localized the functionally important heparin/heparan sulfate-binding site of APC.	Heparitin Sulfate	96-111	APC regulator of WNT signaling pathway	Homo sapiens	128-131
11390981-0	2001	Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.	Heparitin Sulfate	142-157	exostosin like glycosyltransferase 1	Homo sapiens	47-52
11304538-2	2001	The heparan sulfate side chains of syndecan-1 on human salivary gland cells were previously identified as the cell surface ligand for AG73.	Heparitin Sulfate	4-19	syndecan 1	Homo sapiens	35-45
11390981-0	2001	Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.	Heparitin Sulfate	142-157	exostosin like glycosyltransferase 3	Homo sapiens	57-62
11390981-1	2001	The tumor suppressors EXT1 and EXT2 are associated with hereditary multiple exostoses and encode bifunctional glycosyltransferases essential for chain polymerization of heparan sulfate (HS) and its analog, heparin (Hep).	Heparitin Sulfate	169-184	exostosin glycosyltransferase 1	Homo sapiens	22-26
11390981-1	2001	The tumor suppressors EXT1 and EXT2 are associated with hereditary multiple exostoses and encode bifunctional glycosyltransferases essential for chain polymerization of heparan sulfate (HS) and its analog, heparin (Hep).	Heparitin Sulfate	169-184	exostosin glycosyltransferase 2	Homo sapiens	31-35
11390981-1	2001	The tumor suppressors EXT1 and EXT2 are associated with hereditary multiple exostoses and encode bifunctional glycosyltransferases essential for chain polymerization of heparan sulfate (HS) and its analog, heparin (Hep).	Heparitin Sulfate	186-188	exostosin glycosyltransferase 1	Homo sapiens	22-26
11390981-1	2001	The tumor suppressors EXT1 and EXT2 are associated with hereditary multiple exostoses and encode bifunctional glycosyltransferases essential for chain polymerization of heparan sulfate (HS) and its analog, heparin (Hep).	Heparitin Sulfate	186-188	exostosin glycosyltransferase 2	Homo sapiens	31-35
11494510-0	2001	[Heparanase: heparan sulfate specific endo-beta-D-glucuronidase].	Heparitin Sulfate	13-28	glucuronidase beta	Homo sapiens	43-63
12084985-3	2001	MK bound to heparan sulfate chains of glypican-2 in a manner similar to syndecan-3.	Heparitin Sulfate	12-27	midkine	Mus musculus	0-2
12084985-3	2001	MK bound to heparan sulfate chains of glypican-2 in a manner similar to syndecan-3.	Heparitin Sulfate	12-27	glypican 2 (cerebroglycan)	Mus musculus	38-48
11356864-0	2001	Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans.	Heparitin Sulfate	106-121	neurofibromin 1	Homo sapiens	64-77
11356864-0	2001	Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans.	Heparitin Sulfate	106-121	syndecan 1	Homo sapiens	83-91
11380810-3	2001	Furthermore, in many cells, the activity of FGF-2 is controlled by a low-affinity but high-capacity interaction with heparan sulfate (HS) proteoglycans (PGs), such as members of the syndecan family.	Heparitin Sulfate	117-132	fibroblast growth factor 2	Homo sapiens	44-49
11380810-3	2001	Furthermore, in many cells, the activity of FGF-2 is controlled by a low-affinity but high-capacity interaction with heparan sulfate (HS) proteoglycans (PGs), such as members of the syndecan family.	Heparitin Sulfate	134-136	fibroblast growth factor 2	Homo sapiens	44-49
11380810-11	2001	The addition of conditioned medium, containing HS-GAG fragments, restored the proliferative response to FGF-2, confirming the specificity of the interaction.	Heparitin Sulfate	47-49	fibroblast growth factor 2	Homo sapiens	104-109
11145957-6	2001	An N-terminal human pro-IAPP fragment (residues 1-30) was retained by both heparin-agarose and heparan sulfate-Sepharose, eluting at 0.18 m NaCl at pH 7.5.	Heparitin Sulfate	95-110	islet amyloid polypeptide	Homo sapiens	24-28
11278860-0	2001	Binding of heparin/heparan sulfate to fibroblast growth factor receptor 4.	Heparitin Sulfate	19-34	fibroblast growth factor receptor 4	Homo sapiens	38-73
11278892-13	2001	These findings indicate that dHS6ST is required for tracheal development in Drosophila and suggest the evolutionally conserved roles of 6-O-sulfated heparan sulfate in FGF signaling.	Heparitin Sulfate	149-164	Heparan sulfate 6-O-sulfotransferase	Drosophila melanogaster	29-35
11278892-13	2001	These findings indicate that dHS6ST is required for tracheal development in Drosophila and suggest the evolutionally conserved roles of 6-O-sulfated heparan sulfate in FGF signaling.	Heparitin Sulfate	149-164	branchless	Drosophila melanogaster	168-171
11274177-0	2001	Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate.	Heparitin Sulfate	94-109	glucuronyl C5-epimerase	Mus musculus	24-49
11274177-1	2001	The murine gene for the glucuronyl C5-epimerase involved in heparan sulfate biosynthesis was cloned, using a previously isolated bovine lung cDNA fragment (Li, J.-P., Hagner-McWhirter, A., Kjellen, L., Palgi, J., Jalkanen, M., and Lindahl, U.	Heparitin Sulfate	60-75	glucuronyl C5-epimerase	Mus musculus	24-47
11399919-0	2001	Increased glomerular cell heparan sulfates in vitro by ciclosporin A: a Possible explanation of Its beneficial effect in idiopathic nephrotic syndrome.	Heparitin Sulfate	26-42	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	55-68
11278670-3	2001	Glycosaminoglycan heparin/heparan sulfate binding ability was also detected in Ym1.	Heparitin Sulfate	26-41	chitinase-like 3	Mus musculus	79-82
11278641-10	2001	Heparan sulfate cell surface receptors are able to interact with proteins bearing domains 10 and 11, suggesting that tenascin-X may activate different signals to regulate cell behavior.	Heparitin Sulfate	0-15	tenascin XB	Bos taurus	117-127
11259264-1	2001	Using a variety of approaches, we have examined the expression of the heparin/heparan sulfate (Hp/HS) interacting protein/ribosomal protein L29 (HIP/RPL29) in mouse uteri during the estrous cycle and early pregnancy.	Heparitin Sulfate	78-93	ribosomal protein L29	Mus musculus	149-154
11333985-5	2001	Newborn mice deficient in syndecan-1 resist P. aeruginosa lung infection but become susceptible when given purified syndecan-1 ectodomains or heparin, but not when given ectodomain core protein, indicating that the ectodomain"s heparan sulphate chains are the effectors.	Heparitin Sulfate	228-244	syndecan 1	Mus musculus	26-36
11145959-8	2001	It is shown additionally that biglycan expressed in 293 cells may still contain the propeptide sequence and may carry heparan sulfate chains as well as sulfated N-linked oligosaccharides.	Heparitin Sulfate	118-133	biglycan	Homo sapiens	30-38
11284741-8	2001	Despite this, the heparan sulphate of RT101- and JB6-derived perlecan bound fibroblast growth factor-1, -2, -4 and -7 and heparin-binding epidermal growth factor with similar affinity.	Heparitin Sulfate	18-34	fibroblast growth factor 1	Homo sapiens	76-117
11118430-1	2001	A potential role of heparan sulfate binding in PLA2 internalization and degradation.	Heparitin Sulfate	20-35	phospholipase A2 group IB	Homo sapiens	47-51
11118430-12	2001	Finally, the temporal and spatial resolution of exogenously added hVPLA(2) and mutants suggests that binding to cell surface heparan sulfate proteoglycans is important for the internalization and clearance of cell surface-bound hVPLA(2).	Heparitin Sulfate	125-140	phospholipase A2 group V	Homo sapiens	66-74
11118430-12	2001	Finally, the temporal and spatial resolution of exogenously added hVPLA(2) and mutants suggests that binding to cell surface heparan sulfate proteoglycans is important for the internalization and clearance of cell surface-bound hVPLA(2).	Heparitin Sulfate	125-140	phospholipase A2 group V	Homo sapiens	228-236
11356148-1	2001	The unc-52 gene encodes the nematode homologue of mammalian perlecan, the major heparan sulphate proteoglycan of the extracellular matrix.	Heparitin Sulfate	80-96	Basement membrane proteoglycan;Ig-like domain-containing protein	Caenorhabditis elegans	4-10
11405118-4	2001	In glomeruli of patients with IDMS and DDS, the glomerular basement membrane (GBM) expression of the heparan sulfate chain of heparan sulfate proteoglycan (HSPG) was decreased from the early stage of DMS, at a time when ECM proteins retained a normal distribution.	Heparitin Sulfate	101-116	CD44 molecule (Indian blood group)	Homo sapiens	126-154
11405118-4	2001	In glomeruli of patients with IDMS and DDS, the glomerular basement membrane (GBM) expression of the heparan sulfate chain of heparan sulfate proteoglycan (HSPG) was decreased from the early stage of DMS, at a time when ECM proteins retained a normal distribution.	Heparitin Sulfate	101-116	CD44 molecule (Indian blood group)	Homo sapiens	156-160
11405118-10	2001	Early decreased GBM expression of the heparan sulfate chain of HSPG could play a role in the proteinuria of DMS patients.	Heparitin Sulfate	38-53	CD44 molecule (Indian blood group)	Homo sapiens	63-67
11294809-1	2001	BACKGROUND: Extracellular superoxide dismutase (Ec-SOD) may protect the heart against myocardial infarction (MI) because of its extended half-life and capacity to bind heparan sulfate proteoglycans on cellular surfaces.	Heparitin Sulfate	168-183	extracellular superoxide dismutase [Cu-Zn]	Oryctolagus cuniculus	12-46
11294809-1	2001	BACKGROUND: Extracellular superoxide dismutase (Ec-SOD) may protect the heart against myocardial infarction (MI) because of its extended half-life and capacity to bind heparan sulfate proteoglycans on cellular surfaces.	Heparitin Sulfate	168-183	extracellular superoxide dismutase [Cu-Zn]	Oryctolagus cuniculus	48-54
11599124-9	2001	Furthermore, heparin and HS inhibited ET-1-induced activation of extracellular signal-regulated kinase (ERK) and phosphorylation of Elk-1, which is one of the TCFs.	Heparitin Sulfate	25-27	endothelin 1	Rattus norvegicus	38-42
11599124-0	2001	Heparin and heparan sulfate inhibit extracellular signal-regulated kinase activation and myocardial cell hypertrophy induced by endothelin-1.	Heparitin Sulfate	12-27	Eph receptor B1	Rattus norvegicus	36-73
11599124-0	2001	Heparin and heparan sulfate inhibit extracellular signal-regulated kinase activation and myocardial cell hypertrophy induced by endothelin-1.	Heparitin Sulfate	12-27	endothelin 1	Rattus norvegicus	128-140
11599124-3	2001	We examined the intracellular signal mechanisms linking to the inhibitory effects of heparin and HS on endothelin-1 (ET-1)-induced hypertrophy in cultured rat neonatal myocardial cells (MCs).	Heparitin Sulfate	97-99	endothelin 1	Rattus norvegicus	103-115
11599124-3	2001	We examined the intracellular signal mechanisms linking to the inhibitory effects of heparin and HS on endothelin-1 (ET-1)-induced hypertrophy in cultured rat neonatal myocardial cells (MCs).	Heparitin Sulfate	97-99	endothelin 1	Rattus norvegicus	117-121
11599124-9	2001	Furthermore, heparin and HS inhibited ET-1-induced activation of extracellular signal-regulated kinase (ERK) and phosphorylation of Elk-1, which is one of the TCFs.	Heparitin Sulfate	25-27	Eph receptor B1	Rattus norvegicus	65-102
11599124-9	2001	Furthermore, heparin and HS inhibited ET-1-induced activation of extracellular signal-regulated kinase (ERK) and phosphorylation of Elk-1, which is one of the TCFs.	Heparitin Sulfate	25-27	Eph receptor B1	Rattus norvegicus	104-107
11599124-9	2001	Furthermore, heparin and HS inhibited ET-1-induced activation of extracellular signal-regulated kinase (ERK) and phosphorylation of Elk-1, which is one of the TCFs.	Heparitin Sulfate	25-27	ETS transcription factor ELK1	Rattus norvegicus	132-137
11599124-11	2001	Moreover, heparin and HS inhibited ET-1-induced [3H] leucine incorporation.	Heparitin Sulfate	22-24	endothelin 1	Rattus norvegicus	35-39
11599124-12	2001	These results suggest that heparin and HS inhibit ET-1 induced myocardial cell hypertrophy through the inhibition of gene expression and protein synthesis.	Heparitin Sulfate	39-41	endothelin 1	Rattus norvegicus	50-54
11148217-2	2001	These factors, chiefly members of the fibroblast growth factor (FGF) gene family, are coupled to the N-terminal heparan sulfate chains, which augment high affinity binding and receptor activation.	Heparitin Sulfate	112-127	fibroblast growth factor 7	Homo sapiens	64-67
11286501-2	2001	Most cases of SGBS appear to arise as a result of either deletions or point mutations within the glypican-3 (GPC3) gene at Xq26, one member of a multigene family encoding for at least six distinct glycosylphophatidylinositol-linked cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	245-260	glypican 3	Homo sapiens	97-107
11286501-2	2001	Most cases of SGBS appear to arise as a result of either deletions or point mutations within the glypican-3 (GPC3) gene at Xq26, one member of a multigene family encoding for at least six distinct glycosylphophatidylinositol-linked cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	245-260	glypican 3	Homo sapiens	109-113
11106649-2	2001	In human embryonic kidney 293 cells, the heparin-binding enzymes sPLA(2)-IIA, -IID, and -V promote stimulus-dependent arachidonic acid release and prostaglandin E(2) production in a manner dependent on the heparan sulfate proteoglycan glypican.	Heparitin Sulfate	206-221	phospholipase A2 group IIA	Homo sapiens	65-72
11120741-4	2001	Recently, we have shown that adhesion of primary human fibroblasts to immobilized Cyr61 is mediated through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans (HSPGs) (Chen, N., Chen, C.-C., and Lau, L.F. (2000) J. Biol.	Heparitin Sulfate	150-165	cellular communication network factor 1	Homo sapiens	82-87
11106655-0	2001	Mechanisms underlying preferential assembly of heparan sulfate on glypican-1.	Heparitin Sulfate	47-62	glypican 1	Rattus norvegicus	66-76
11277697-1	2001	The growth factor midkine (MK) has been reported to bind heparan sulfate and nucleolin, two components of the cell surface implicated in the attachment of HIV-1 particles.	Heparitin Sulfate	57-72	midkine	Homo sapiens	18-25
11106655-3	2001	By using a novel quantitative approach for assessing proteoglycan glycosylation, we show here that removal of the globular domain from rat glypican-1 converts the proteoglycan from one that bears approximately 90% heparan sulfate (HS) to one that bears approximately 90% chondroitin sulfate.	Heparitin Sulfate	214-229	glypican 1	Rattus norvegicus	139-149
11106655-3	2001	By using a novel quantitative approach for assessing proteoglycan glycosylation, we show here that removal of the globular domain from rat glypican-1 converts the proteoglycan from one that bears approximately 90% heparan sulfate (HS) to one that bears approximately 90% chondroitin sulfate.	Heparitin Sulfate	231-233	glypican 1	Rattus norvegicus	139-149
11307829-5	2001	Alternatively, peptide T249-F260 of FXI"s apple domain 3 and heparin monosulfate were weak inhibitors of FXI binding to HUVEC.	Heparitin Sulfate	61-80	coagulation factor XI	Homo sapiens	105-108
11320057-6	2001	Moreover, we have shown that five heparan sulfate core proteins mRNA (perlecan; syndecan-1, -2, and -4; and glypican-1) are synthesized by granulosa cells, providing attachment for anticoagulant heparan sulfate chains on the cell surface and in the extracellular matrix.	Heparitin Sulfate	34-49	syndecan 1	Rattus norvegicus	80-102
11320057-6	2001	Moreover, we have shown that five heparan sulfate core proteins mRNA (perlecan; syndecan-1, -2, and -4; and glypican-1) are synthesized by granulosa cells, providing attachment for anticoagulant heparan sulfate chains on the cell surface and in the extracellular matrix.	Heparitin Sulfate	195-210	syndecan 1	Rattus norvegicus	80-102
11110783-0	2001	N-unsubstituted glucosamine in heparan sulfate of recycling glypican-1 from suramin-treated and nitrite-deprived endothelial cells.	Heparitin Sulfate	31-46	glypican 1	Homo sapiens	60-70
11087757-2	2001	We report the cloning and partial characterization of the fourth member of the vertebrate heparan sulfate/heparin: GlcNAc N-deacetylase/GlcN N-sulfotransferase family, which we designate NDST4.	Heparitin Sulfate	90-105	N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4	Mus musculus	187-192
11121397-0	2001	rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.	Heparitin Sulfate	195-210	Exostosin-2 homolog	Caenorhabditis elegans	0-5
11121397-0	2001	rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.	Heparitin Sulfate	195-210	exostosin glycosyltransferase 1	Homo sapiens	70-73
11121397-0	2001	rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.	Heparitin Sulfate	195-210	alpha-1,4-N-acetylglucosaminyltransferase	Homo sapiens	96-136
11121397-1	2001	The proteins encoded by the EXT1, EXT2, and EXTL2 genes, members of the hereditary multiple exostoses gene family of tumor suppressors, are glycosyltransferases required for the heparan sulfate biosynthesis.	Heparitin Sulfate	178-193	exostosin glycosyltransferase 1	Homo sapiens	28-32
11121397-1	2001	The proteins encoded by the EXT1, EXT2, and EXTL2 genes, members of the hereditary multiple exostoses gene family of tumor suppressors, are glycosyltransferases required for the heparan sulfate biosynthesis.	Heparitin Sulfate	178-193	exostosin glycosyltransferase 2	Homo sapiens	34-38
11121397-1	2001	The proteins encoded by the EXT1, EXT2, and EXTL2 genes, members of the hereditary multiple exostoses gene family of tumor suppressors, are glycosyltransferases required for the heparan sulfate biosynthesis.	Heparitin Sulfate	178-193	exostosin like glycosyltransferase 2	Homo sapiens	44-49
11121397-5	2001	The present findings revealed that the rib-2 protein was a unique alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.	Heparitin Sulfate	165-180	Exostosin-2 homolog	Caenorhabditis elegans	39-44
11121397-5	2001	The present findings revealed that the rib-2 protein was a unique alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.	Heparitin Sulfate	165-180	alpha-1,4-N-acetylglucosaminyltransferase	Homo sapiens	66-106
11121397-6	2001	In contrast, the findings confirmed the previous observations that both the EXT1 and EXT2 proteins were heparan sulfate copolymerases with both alpha1,4-N-acetylglucosaminyltransferase and beta1,4-glucuronyltransferase activities, which are involved only in the elongation step of the heparan sulfate chain, and that the EXTL2 protein was an alpha1,4-N-acetylglucosaminyltransferase involved only in the initiation of heparan sulfate synthesis.	Heparitin Sulfate	104-119	exostosin glycosyltransferase 1	Homo sapiens	76-80
11121397-6	2001	In contrast, the findings confirmed the previous observations that both the EXT1 and EXT2 proteins were heparan sulfate copolymerases with both alpha1,4-N-acetylglucosaminyltransferase and beta1,4-glucuronyltransferase activities, which are involved only in the elongation step of the heparan sulfate chain, and that the EXTL2 protein was an alpha1,4-N-acetylglucosaminyltransferase involved only in the initiation of heparan sulfate synthesis.	Heparitin Sulfate	104-119	exostosin glycosyltransferase 2	Homo sapiens	85-89
11121397-6	2001	In contrast, the findings confirmed the previous observations that both the EXT1 and EXT2 proteins were heparan sulfate copolymerases with both alpha1,4-N-acetylglucosaminyltransferase and beta1,4-glucuronyltransferase activities, which are involved only in the elongation step of the heparan sulfate chain, and that the EXTL2 protein was an alpha1,4-N-acetylglucosaminyltransferase involved only in the initiation of heparan sulfate synthesis.	Heparitin Sulfate	104-119	alpha-1,4-N-acetylglucosaminyltransferase	Homo sapiens	144-184
11121397-6	2001	In contrast, the findings confirmed the previous observations that both the EXT1 and EXT2 proteins were heparan sulfate copolymerases with both alpha1,4-N-acetylglucosaminyltransferase and beta1,4-glucuronyltransferase activities, which are involved only in the elongation step of the heparan sulfate chain, and that the EXTL2 protein was an alpha1,4-N-acetylglucosaminyltransferase involved only in the initiation of heparan sulfate synthesis.	Heparitin Sulfate	104-119	exostosin like glycosyltransferase 2	Homo sapiens	321-326
11121397-6	2001	In contrast, the findings confirmed the previous observations that both the EXT1 and EXT2 proteins were heparan sulfate copolymerases with both alpha1,4-N-acetylglucosaminyltransferase and beta1,4-glucuronyltransferase activities, which are involved only in the elongation step of the heparan sulfate chain, and that the EXTL2 protein was an alpha1,4-N-acetylglucosaminyltransferase involved only in the initiation of heparan sulfate synthesis.	Heparitin Sulfate	104-119	alpha-1,4-N-acetylglucosaminyltransferase	Homo sapiens	342-382
11121397-6	2001	In contrast, the findings confirmed the previous observations that both the EXT1 and EXT2 proteins were heparan sulfate copolymerases with both alpha1,4-N-acetylglucosaminyltransferase and beta1,4-glucuronyltransferase activities, which are involved only in the elongation step of the heparan sulfate chain, and that the EXTL2 protein was an alpha1,4-N-acetylglucosaminyltransferase involved only in the initiation of heparan sulfate synthesis.	Heparitin Sulfate	285-300	exostosin glycosyltransferase 1	Homo sapiens	76-80
11121397-6	2001	In contrast, the findings confirmed the previous observations that both the EXT1 and EXT2 proteins were heparan sulfate copolymerases with both alpha1,4-N-acetylglucosaminyltransferase and beta1,4-glucuronyltransferase activities, which are involved only in the elongation step of the heparan sulfate chain, and that the EXTL2 protein was an alpha1,4-N-acetylglucosaminyltransferase involved only in the initiation of heparan sulfate synthesis.	Heparitin Sulfate	285-300	exostosin glycosyltransferase 2	Homo sapiens	85-89
11342172-1	2001	We show that cell surface glycans, sialic acid and mannose-containing species, are involved beside glycosaminoglycans (GAGs), heparan sulfate and chondroitin sulfate in the binding of full length (1--68) RANTES not only to CCR5 positive human primary lymphocytes or macrophages but also to CCR5 negative monocytic U937 cells.	Heparitin Sulfate	126-141	C-C motif chemokine receptor 5	Homo sapiens	223-227
11110783-2	2001	We have analyzed the content of N-unsubstituted glucosamine in heparan sulfate from glypican-1 synthesized by endothelial cells during inhibition of (a) intracellular progression by brefeldin A, (b) heparan sulfate degradation by suramin, and/or (c) endogenous nitrite formation.	Heparitin Sulfate	63-78	glypican 1	Homo sapiens	84-94
11342172-1	2001	We show that cell surface glycans, sialic acid and mannose-containing species, are involved beside glycosaminoglycans (GAGs), heparan sulfate and chondroitin sulfate in the binding of full length (1--68) RANTES not only to CCR5 positive human primary lymphocytes or macrophages but also to CCR5 negative monocytic U937 cells.	Heparitin Sulfate	126-141	C-C motif chemokine receptor 5	Homo sapiens	290-294
11110783-2	2001	We have analyzed the content of N-unsubstituted glucosamine in heparan sulfate from glypican-1 synthesized by endothelial cells during inhibition of (a) intracellular progression by brefeldin A, (b) heparan sulfate degradation by suramin, and/or (c) endogenous nitrite formation.	Heparitin Sulfate	199-214	glypican 1	Homo sapiens	84-94
11110783-3	2001	Glypican-1 from brefeldin A-treated cells carried heparan sulfate chains that were extensively degraded by nitrous acid at pH 3.9, indicating the presence of glucosamines with free amino groups.	Heparitin Sulfate	50-65	glypican 1	Homo sapiens	0-10
11169736-0	2001	Heparan sulfate and chondroitin sulfate proteoglycans inhibit E-selectin binding to endothelial cells.	Heparitin Sulfate	0-15	selectin E	Homo sapiens	62-72
11257457-1	2001	EXTL3/EXTR1 is a member of the EXT gene family, which may represent a class of glycosyltransferases involved in heparan sulfate biosynthesis.	Heparitin Sulfate	112-127	exostosin like glycosyltransferase 3	Homo sapiens	0-5
11257457-1	2001	EXTL3/EXTR1 is a member of the EXT gene family, which may represent a class of glycosyltransferases involved in heparan sulfate biosynthesis.	Heparitin Sulfate	112-127	exostosin like glycosyltransferase 3	Homo sapiens	6-11
11732625-3	2001	Insulin and WGA stimulated [3H]glucosamine incorporation into hyaluronic acid (HA) and heparan sulphate (HS) without any alteration of chondroitin sulphate (CS) and dermatan sulphate (DS) contents.	Heparitin Sulfate	87-103	insulin	Homo sapiens	0-7
11732625-3	2001	Insulin and WGA stimulated [3H]glucosamine incorporation into hyaluronic acid (HA) and heparan sulphate (HS) without any alteration of chondroitin sulphate (CS) and dermatan sulphate (DS) contents.	Heparitin Sulfate	105-107	insulin	Homo sapiens	0-7
11591215-8	2001	In addition, cell adhesion to III1-C and ERK1/2 activation by III1-C are both inhibited by heparan sulfate but not by chondroitin sulfate.	Heparitin Sulfate	91-106	mitogen activated protein kinase 3	Rattus norvegicus	41-47
11169844-6	2001	Finally, targeted exon deletion of the VEGF gene revealed that mice that developed in the absence of the heparan sulfate binding isoforms VEGF164 and VEGF188, displayed a variety of vascular defects, including abnormal pulmonary vascular development.	Heparitin Sulfate	105-120	vascular endothelial growth factor A	Mus musculus	39-43
11159885-0	2001	Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1 beta secretion by intestinal epithelial cells.	Heparitin Sulfate	38-53	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
11159885-0	2001	Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1 beta secretion by intestinal epithelial cells.	Heparitin Sulfate	38-53	interleukin 1 beta	Homo sapiens	72-81
11167146-3	2001	The enzyme cleaves heparan sulfate (HS), a main component of ECM and BM.	Heparitin Sulfate	19-34	multimerin 1	Homo sapiens	61-64
11167146-3	2001	The enzyme cleaves heparan sulfate (HS), a main component of ECM and BM.	Heparitin Sulfate	36-38	multimerin 1	Homo sapiens	61-64
11016923-11	2001	These results strongly suggest that heparan sulfate may be an important binding site for cathepsin B at cell surface, reporting a novel physiological role for heparan sulfate proteoglycans.	Heparitin Sulfate	36-51	cathepsin B	Homo sapiens	89-100
11169736-6	2001	These results suggest that heparan sulfate and chondroitin sulfate proteoglycans on endothelial cells are potential ligands for E-selectin.	Heparitin Sulfate	27-42	selectin E	Homo sapiens	128-138
11746503-1	2001	Heparan sulfate inhibits the proliferation of normal human lung fibroblasts (HFL-1) but not of a human lung carcinoma cell-line (A549).	Heparitin Sulfate	0-15	complement factor H related 1	Homo sapiens	77-82
11007795-0	2000	The amino-terminal part of PRELP binds to heparin and heparan sulfate.	Heparitin Sulfate	54-69	proline and arginine rich end leucine rich repeat protein	Homo sapiens	27-32
11746503-4	2001	The antiproliferative heparan sulfate was bound to the cell surface on both HFL-1 and A549 cells, but to a lesser extent and with less affinity to A549 cells.	Heparitin Sulfate	22-37	complement factor H related 1	Homo sapiens	76-81
11746503-7	2001	The antiproliferative heparan sulfate accumulated in the cytoplasm of HFL-1 cells after 24 h incubation, but after 72 h it was found evenly distributed in the nucleus.	Heparitin Sulfate	22-37	complement factor H related 1	Homo sapiens	70-75
11007795-5	2000	We show here that PRELP indeed binds heparin and heparan sulfate.	Heparitin Sulfate	49-64	proline and arginine rich end leucine rich repeat protein	Homo sapiens	18-23
11084653-1	2000	Syndecan-4 is a transmembrane protein bearing heparan sulfate chains, involved in anticoagulation and focal adhesion formation.	Heparitin Sulfate	46-61	syndecan 4	Homo sapiens	0-10
11123893-0	2000	Multiple domains contribute to heparin/heparan sulfate binding by human HIP/L29.	Heparitin Sulfate	39-54	ribosomal protein L29	Homo sapiens	72-79
11123893-1	2000	Human heparin/heparan sulfate interacting protein/L29 (HIP/L29) is thought to be involved in the promotion of cell adhesion, the promotion of cell growth in the cancerous state, and the modulation of blood coagulation.	Heparitin Sulfate	14-29	ribosomal protein L29	Homo sapiens	55-62
11123893-2	2000	These activities are consistent with the proposed function of HIP/L29 as a heparin/heparan sulfate (Hp/HS) binding growth factor that has a preference for anticoagulantly active Hp/HS.	Heparitin Sulfate	83-98	ribosomal protein L29	Homo sapiens	62-69
11106599-1	2000	Heparan sulfate N-deacetylase/N-sulfotransferase (NDST) catalyzes the deacetylation and sulfation of N-acetyl-D-glucosamine residues of heparan sulfate, a key step in its biosynthesis.	Heparitin Sulfate	136-151	N-deacetylase and N-sulfotransferase 1	Homo sapiens	0-48
11153910-1	2000	Sanfilippo syndrome type B (mucopolysaccharidosis IIIB) is a rare autosomal recessive disorder characterized by the inability to degrade heparan sulfate because of a deficiency of the lysosomal enzyme alpha-N-acetylglucosaminidase (NAGLU).	Heparitin Sulfate	137-152	N-acetyl-alpha-glucosaminidase	Homo sapiens	201-230
11068184-1	2000	Mucopolysaccharidosis type IIIB (MPS-IIB) is a lysosomal storage disorder characterised by the defective degradation of heparan sulfate due to a deficiency of alpha-N-acetylglucosaminidase (NAG).	Heparitin Sulfate	120-135	N-acetyl-alpha-glucosaminidase	Homo sapiens	159-188
10978312-1	2000	The heparin-binding neurotrophic factor midkine (MK) has been proposed to mediate neuronal cell adhesion and neurite outgrowth promotion by interacting with cell-surface heparan sulfate.	Heparitin Sulfate	170-185	midkine	Rattus norvegicus	40-47
11087710-1	2000	The interaction of heparan sulfate (HS) (and the closely related molecule heparin) with FGF-1 is a requirement for enabling the growth factor to activate its cell surface tyrosine kinase receptor.	Heparitin Sulfate	19-34	fibroblast growth factor 1	Homo sapiens	88-93
10950950-3	2000	The binding of versican to L- and P-selectin was inhibited by CS B, CS E, and heparan sulfate (HS) but not by any other glycosaminoglycans tested.	Heparitin Sulfate	78-93	versican	Homo sapiens	15-23
10950950-3	2000	The binding of versican to L- and P-selectin was inhibited by CS B, CS E, and heparan sulfate (HS) but not by any other glycosaminoglycans tested.	Heparitin Sulfate	78-93	selectin P	Homo sapiens	34-44
10950950-3	2000	The binding of versican to L- and P-selectin was inhibited by CS B, CS E, and heparan sulfate (HS) but not by any other glycosaminoglycans tested.	Heparitin Sulfate	95-97	versican	Homo sapiens	15-23
10950950-3	2000	The binding of versican to L- and P-selectin was inhibited by CS B, CS E, and heparan sulfate (HS) but not by any other glycosaminoglycans tested.	Heparitin Sulfate	95-97	selectin P	Homo sapiens	34-44
11073815-3	2000	Recently, we obtained evidence for functional collaboration between these two molecules: CD44 isoforms decorated with heparan sulfate chains (CD44-HS) can bind the c-Met ligand, the growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF).	Heparitin Sulfate	118-133	CD44 molecule (Indian blood group)	Homo sapiens	89-93
11073815-3	2000	Recently, we obtained evidence for functional collaboration between these two molecules: CD44 isoforms decorated with heparan sulfate chains (CD44-HS) can bind the c-Met ligand, the growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF).	Heparitin Sulfate	118-133	CD44 molecule (Indian blood group)	Homo sapiens	142-146
11073815-3	2000	Recently, we obtained evidence for functional collaboration between these two molecules: CD44 isoforms decorated with heparan sulfate chains (CD44-HS) can bind the c-Met ligand, the growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF).	Heparitin Sulfate	118-133	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	164-169
11073815-3	2000	Recently, we obtained evidence for functional collaboration between these two molecules: CD44 isoforms decorated with heparan sulfate chains (CD44-HS) can bind the c-Met ligand, the growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF).	Heparitin Sulfate	118-133	hepatocyte growth factor	Homo sapiens	250-256
11049995-6	2000	Because HGF is a heparan-sulfate binding cytokine, we examined whether it interacted with soluble syndecan-1.	Heparitin Sulfate	17-32	hepatocyte growth factor	Homo sapiens	8-11
11066092-8	2000	Recombinant glypican-4 produced in immortalized neural precursor cells binds FGF2 through its heparan sulfate chains and suppressed the mitogenic effect of FGF2 on E13 cortical precursor cells.	Heparitin Sulfate	94-109	glypican 4	Rattus norvegicus	12-22
11066092-8	2000	Recombinant glypican-4 produced in immortalized neural precursor cells binds FGF2 through its heparan sulfate chains and suppressed the mitogenic effect of FGF2 on E13 cortical precursor cells.	Heparitin Sulfate	94-109	fibroblast growth factor 2	Rattus norvegicus	77-81
11087710-1	2000	The interaction of heparan sulfate (HS) (and the closely related molecule heparin) with FGF-1 is a requirement for enabling the growth factor to activate its cell surface tyrosine kinase receptor.	Heparitin Sulfate	36-38	fibroblast growth factor 1	Homo sapiens	88-93
11087710-4	2000	Mitogenic activation assays using these oligosaccharides showed that HS contained both FGF-1 activatory and inhibitory sugar sequences.	Heparitin Sulfate	69-71	fibroblast growth factor 1	Homo sapiens	87-92
10843988-7	2000	Cloning and over-expression of the major endothelial heparan sulfate-type proteoglycans syndecan-1, syndecan-2, syndecan-4, and glypican in HEK293t cells significantly increased total heparan sulfate at the cell surface and thus the number of kininogen binding sites (up to 3.	Heparitin Sulfate	53-68	syndecan 1	Homo sapiens	88-98
10843988-7	2000	Cloning and over-expression of the major endothelial heparan sulfate-type proteoglycans syndecan-1, syndecan-2, syndecan-4, and glypican in HEK293t cells significantly increased total heparan sulfate at the cell surface and thus the number of kininogen binding sites (up to 3.	Heparitin Sulfate	184-199	syndecan 1	Homo sapiens	88-98
11069186-8	2000	The structure of the FGF1-FGFR2-heparin ternary complex provides a structural basis for the essential role of heparan sulphate in FGF signalling.	Heparitin Sulfate	110-126	fibroblast growth factor 1	Homo sapiens	21-25
11069186-8	2000	The structure of the FGF1-FGFR2-heparin ternary complex provides a structural basis for the essential role of heparan sulphate in FGF signalling.	Heparitin Sulfate	110-126	fibroblast growth factor receptor 2	Homo sapiens	26-31
10944532-0	2000	Fibroblast growth factor-2 stimulation of p42/44MAPK phosphorylation and IkappaB degradation is regulated by heparan sulfate/heparin in rat mammary fibroblasts.	Heparitin Sulfate	109-124	fibroblast growth factor 2	Rattus norvegicus	0-26
10900194-2	2000	The present results show that glycosaminoglycans such as heparin, heparan sulfate, chondroitin sulfates A, B, and C, and sulfated compounds such as suramin and pentosan efficiently extract TIMP-3 from the postpartum rat uterus.	Heparitin Sulfate	66-81	TIMP metallopeptidase inhibitor 3	Rattus norvegicus	189-195
11027606-2	2000	Cleavage of heparan sulfate by heparanase, an endoglycosidase, is implicated in the extravasation of leukocytes and metastatic tumour cells, identifying this enzyme(s) as a target for anti-inflammatory and anti-metastatic therapies.	Heparitin Sulfate	12-27	heparanase	Homo sapiens	31-41
11001907-1	2000	Syndecan-1 (CD138) is a heparan sulfate-bearing proteoglycan present on the surface of myeloma cells where it mediates myeloma cell-cell and cell-extracellular matrix adhesion.	Heparitin Sulfate	24-39	syndecan 1	Homo sapiens	0-10
11021821-2	2000	The human heparanase gene, an endo-beta-glucuronidase that cleaves heparan sulfate at specific intrachain sites, has recently been cloned and shown to function in tumor progression and metastatic spread.	Heparitin Sulfate	67-82	heparanase	Homo sapiens	10-20
11001907-1	2000	Syndecan-1 (CD138) is a heparan sulfate-bearing proteoglycan present on the surface of myeloma cells where it mediates myeloma cell-cell and cell-extracellular matrix adhesion.	Heparitin Sulfate	24-39	syndecan 1	Homo sapiens	12-17
11215206-3	2000	The biological functions of this enzyme in vivo were as follows: 1) this enzyme accelerates cancer cell invasion and metastasis though the degradation of vascular basement membrane and extracellular matrix by cancer cells; 2) this enzyme releases and activates heparin-binding growth factors such as bFGF and VEGF from heparan sulfate proteoglycans, and induces angiogenesis; 3) the degradative products of heparan sulfate proteoglycans by this enzyme suppress the biological function of activated T-lymphocytes.	Heparitin Sulfate	319-334	fibroblast growth factor 2	Homo sapiens	300-304
11089917-9	2000	These observations could best be explained by assuming that LpL/LDL complexes are internalized upon binding to membrane-associated heparan sulphate and that small proteoglycans interfere with this process.	Heparitin Sulfate	131-147	lipoprotein lipase	Homo sapiens	60-63
11027487-1	2000	In the presence of FGF-2, cells in suspension expressing FGF receptor-1 will attach to monolayers of cells expressing heparan sulfates.	Heparitin Sulfate	118-134	fibroblast growth factor 2	Cricetulus griseus	19-24
11129947-1	2000	Altered lipoprotein lipase regulation associated with diabetes leading to the development of hypertriglyceridemia might be attributed to possible changes in content and the fine structure of heparan sulfate and its associated lipoprotein lipase.	Heparitin Sulfate	191-206	lipoprotein lipase	Mus musculus	8-26
11129947-1	2000	Altered lipoprotein lipase regulation associated with diabetes leading to the development of hypertriglyceridemia might be attributed to possible changes in content and the fine structure of heparan sulfate and its associated lipoprotein lipase.	Heparitin Sulfate	191-206	lipoprotein lipase	Mus musculus	226-244
11129947-2	2000	Adipocyte cell surface is the primary site of synthesis of lipoprotein lipase and the enzyme is bound to cell surface heparan sulfate proteoglycans via heparan sulfate side chains.	Heparitin Sulfate	118-133	lipoprotein lipase	Mus musculus	59-77
11129947-2	2000	Adipocyte cell surface is the primary site of synthesis of lipoprotein lipase and the enzyme is bound to cell surface heparan sulfate proteoglycans via heparan sulfate side chains.	Heparitin Sulfate	152-167	lipoprotein lipase	Mus musculus	59-77
11129947-7	2000	The activity and message levels for N-deacetylase/N-sulfotransferase, the enzyme responsible for N-sulfation in the biosynthesis of heparan sulfate, did not vary in adipocytes whether they were exposed to low or high glucose.	Heparitin Sulfate	132-147	sulfotransferase family 1D, member 1	Mus musculus	50-68
11129947-9	2000	Heparan sulfate from adipocytes cultured in low glucose conditions binds to lipoprotein lipase by the same order of magnitude as that derived from high glucose conditions.	Heparitin Sulfate	0-15	lipoprotein lipase	Mus musculus	76-94
11129947-11	2000	In conclusion, it is possible that the reduction in heparan sulfate in diabetes could contribute to the decreased levels of heparan sulfate associated lipoprotein lipase, leading to diabetic hypertriglyceridemia.	Heparitin Sulfate	52-67	lipoprotein lipase	Mus musculus	151-169
11081250-2	2000	In order to test this hypothesis, we established a simple and sensitive method for detecting FGF-2-binding heparan sulfates and characterized them in papillary thyroid carcinomas and normal thyroids.	Heparitin Sulfate	107-123	fibroblast growth factor 2	Homo sapiens	93-98
11081250-9	2000	Heparan sulfate-containing fractions also showed FGF-2 immunoreactivity, indicating the complex formation of FGF-2 and heparan sulfate.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	49-54
11081250-9	2000	Heparan sulfate-containing fractions also showed FGF-2 immunoreactivity, indicating the complex formation of FGF-2 and heparan sulfate.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	109-114
11081250-9	2000	Heparan sulfate-containing fractions also showed FGF-2 immunoreactivity, indicating the complex formation of FGF-2 and heparan sulfate.	Heparitin Sulfate	119-134	fibroblast growth factor 2	Homo sapiens	49-54
11081250-12	2000	This loss of a subpopulation of FGF-2-binding heparan sulfate in human papillary thyroid carcinomas may lead to the increase of free FGF-2 bioavailable in extracellular matrix.	Heparitin Sulfate	46-61	fibroblast growth factor 2	Homo sapiens	32-37
11081250-12	2000	This loss of a subpopulation of FGF-2-binding heparan sulfate in human papillary thyroid carcinomas may lead to the increase of free FGF-2 bioavailable in extracellular matrix.	Heparitin Sulfate	46-61	fibroblast growth factor 2	Homo sapiens	133-138
11027487-4	2000	In the presence of FGF-2, cells expressing either isoform of the receptor were able to attach to monolayers of CHO cells expressing heparan sulfates.	Heparitin Sulfate	132-148	fibroblast growth factor 2	Cricetulus griseus	19-24
11027487-8	2000	We also found that, in the presence of FGF-2, cells expressing FGF receptor-1 are able to form complexes with both extracellular matrix and cell-surface heparan sulfates.	Heparitin Sulfate	153-169	fibroblast growth factor 2	Cricetulus griseus	39-44
10964499-1	2000	Syndecan-1-expressing Raji lymphoid cells (Raji-S1 cells) bind and spread rapidly when attaching to matrix ligands that contain heparan sulfate-binding domains.	Heparitin Sulfate	128-143	syndecan 1	Homo sapiens	0-10
11006120-0	2000	Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III.	Heparitin Sulfate	26-41	serpin family C member 1	Homo sapiens	85-101
11006120-2	2000	Surface plasmon resonance spectroscopy showed a low affinity interaction with antithrombin III (ATIII) when it was flowed over a surface containing heparan sulfate.	Heparitin Sulfate	148-163	serpin family C member 1	Homo sapiens	78-94
11006120-2	2000	Surface plasmon resonance spectroscopy showed a low affinity interaction with antithrombin III (ATIII) when it was flowed over a surface containing heparan sulfate.	Heparitin Sulfate	148-163	serpin family C member 1	Homo sapiens	96-101
11006120-4	2000	The 3-OST-1 enzyme is involved in heparan sulfate biosynthesis and introduces a critical 3-O-sulfo group into this glycosaminoglycan affording the appropriate pentasaccharide sequence capable of high affinity binding to ATIII.	Heparitin Sulfate	34-49	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	4-11
11006120-4	2000	The 3-OST-1 enzyme is involved in heparan sulfate biosynthesis and introduces a critical 3-O-sulfo group into this glycosaminoglycan affording the appropriate pentasaccharide sequence capable of high affinity binding to ATIII.	Heparitin Sulfate	34-49	serpin family C member 1	Homo sapiens	220-225
10964499-6	2000	These data demonstrate that ligation of syndecan-1 initiates intracellular signaling and suggest that this signaling occurs when cells expressing syndecan-1 adhere to matrix ligands containing heparan sulfate-binding domains.	Heparitin Sulfate	193-208	syndecan 1	Homo sapiens	40-50
10964499-6	2000	These data demonstrate that ligation of syndecan-1 initiates intracellular signaling and suggest that this signaling occurs when cells expressing syndecan-1 adhere to matrix ligands containing heparan sulfate-binding domains.	Heparitin Sulfate	193-208	syndecan 1	Homo sapiens	146-156
10852901-0	2000	Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1.	Heparitin Sulfate	10-25	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	78-112
10852920-2	2000	Previously, we reported the isolation of a heparan sulfate-binding collagenous protein, p200, that is expressed by Schwann cells in developing peripheral nerves ((1996) J. Biol.	Heparitin Sulfate	43-58	AT-rich interaction domain 2	Homo sapiens	88-92
10961890-0	2000	Heparin and heparan sulfate bind interleukin-10 and modulate its activity.	Heparitin Sulfate	12-27	interleukin 10	Homo sapiens	33-47
10961890-6	2000	Soluble heparin, heparan sulfate, chondroitin sulfate, and dermatan sulfate were shown to inhibit the hIL-10-induced expression of CD16 and CD64 in a concentration-dependent manner.	Heparitin Sulfate	17-32	interleukin 10	Homo sapiens	102-108
10961890-6	2000	Soluble heparin, heparan sulfate, chondroitin sulfate, and dermatan sulfate were shown to inhibit the hIL-10-induced expression of CD16 and CD64 in a concentration-dependent manner.	Heparitin Sulfate	17-32	Fc gamma receptor IIIa	Homo sapiens	131-135
10961890-6	2000	Soluble heparin, heparan sulfate, chondroitin sulfate, and dermatan sulfate were shown to inhibit the hIL-10-induced expression of CD16 and CD64 in a concentration-dependent manner.	Heparitin Sulfate	17-32	Fc gamma receptor Ia	Homo sapiens	140-144
10964519-6	2000	These data will provide valuable tools to progress the understanding of HIP/RPL29 function as a ribosomal protein and/or as a regulator of growth and cell adhesion through interaction with heparan sulfate proteoglycans.	Heparitin Sulfate	189-204	ribosomal protein L29	Mus musculus	76-81
10965035-9	2000	Nex-1 binds to heparin, heparan sulfate, and chondroitin sulfate but not to chondroitin and chemically N- or O-desulfated heparin.	Heparitin Sulfate	24-39	Annexin	Caenorhabditis elegans	0-5
10965035-10	2000	Besides phospholipids, heparan sulfate and/or chondroitin (sulfate), probably on perlecan, could be endogenous ligands of Nex-1.	Heparitin Sulfate	23-38	Annexin	Caenorhabditis elegans	122-127
10852901-5	2000	We here report that targeted gene disruption of NDST-1 in the mouse results in a structural alteration of heparan sulfate in most basement membranes as revealed by immunohistochemical staining of fetal tissue sections using antibodies raised against heparan sulfate.	Heparitin Sulfate	106-121	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	48-54
10852901-5	2000	We here report that targeted gene disruption of NDST-1 in the mouse results in a structural alteration of heparan sulfate in most basement membranes as revealed by immunohistochemical staining of fetal tissue sections using antibodies raised against heparan sulfate.	Heparitin Sulfate	250-265	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	48-54
10926850-5	2000	Among five transcription factors studied, AP-1, SP-1, ETS-1 and nuclear factor kappaB proved to be sensitive to heparin and heparan sulphate, whereas TFIID was hardly inhibited in either in vitro or in vivo systems.	Heparitin Sulfate	124-140	ETS proto-oncogene 1, transcription factor	Homo sapiens	54-59
10942383-8	2000	The effect of defensin was substantially increased in cells overexpressing the core protein of the syndecan-1 heparan sulfate proteoglycan.	Heparitin Sulfate	110-125	syndecan 1	Homo sapiens	99-109
10926768-9	2000	The effect of the EXT1 deletion on heparan sulfate formation was tested by HPLC and cellular glycosyltransferase activity assays.	Heparitin Sulfate	35-50	exostosin glycosyltransferase 1	Mus musculus	18-22
10926768-10	2000	Heparan sulfate synthesis was abolished in EXT1 -/- ES cells and decreased to less than 50% in +/- cell lines.	Heparitin Sulfate	0-15	exostosin glycosyltransferase 1	Mus musculus	43-47
10926768-11	2000	These results indicate that EXT1 is essential for both gastrulation and heparan sulfate biosynthesis in early embryonic development.	Heparitin Sulfate	72-87	exostosin glycosyltransferase 1	Mus musculus	28-32
10940902-6	2000	Collectively, these data suggest that while ECM-mediated presentation of IL-7 may be a general function of thymic stromal cells during thymocyte development, heparan sulfate-mediated IL-7 presentation specifically by fibroblasts is not essential and that the specific requirement for fibroblasts in early development involves additional undefined interactions.	Heparitin Sulfate	158-173	interleukin 7	Homo sapiens	183-187
10816596-3	2000	Chinese hamster ovary cells (CHO677) deficient in heparan sulfate biosynthesis were employed to assess the function of heparin/heparan sulfate in FGF receptor-1 (FGFR-1) signal transduction and biological responses.	Heparitin Sulfate	127-142	fibroblast growth factor receptor 1	Cricetulus griseus	146-160
10950929-1	2000	Heparan sulfate sulfamidase (HSS) is a lysosomal exohydrolase that, when deficient, results in intralysosomal accumulation of heparan sulfate and the clinical phenotype of Sanfilippo syndrome type A.	Heparitin Sulfate	126-141	N-sulfoglucosamine sulfohydrolase	Canis lupus familiaris	0-27
10950929-1	2000	Heparan sulfate sulfamidase (HSS) is a lysosomal exohydrolase that, when deficient, results in intralysosomal accumulation of heparan sulfate and the clinical phenotype of Sanfilippo syndrome type A.	Heparitin Sulfate	126-141	N-sulfoglucosamine sulfohydrolase	Canis lupus familiaris	29-32
10940554-1	2000	Heparanase (HPSE), which we have recently isolated, is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate and has been implicated in inflammation and tumor angiogenesis and metastasis.	Heparitin Sulfate	104-119	heparanase	Homo sapiens	0-10
10940554-1	2000	Heparanase (HPSE), which we have recently isolated, is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate and has been implicated in inflammation and tumor angiogenesis and metastasis.	Heparitin Sulfate	104-119	heparanase	Homo sapiens	12-16
10940554-1	2000	Heparanase (HPSE), which we have recently isolated, is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate and has been implicated in inflammation and tumor angiogenesis and metastasis.	Heparitin Sulfate	104-119	glucuronidase beta	Homo sapiens	63-83
10940902-3	2000	We show that MHC class II(+) thymic epithelium and fibroblasts - essential requirements for development of CD4(-)8(-)precursors - both show surface expression of ECM components such as fibronectin and heparan sulfate.	Heparitin Sulfate	201-216	CD4 molecule	Homo sapiens	107-110
10945969-5	2000	The heparan sulfate strands in HSPG are necessary for protein filtration in kidney basement membranes.	Heparitin Sulfate	4-19	CD44 molecule (Indian blood group)	Homo sapiens	31-35
10903769-5	2000	Incubation of immature murine dendritic cells with heparan sulfate induced phenotypic maturation evidenced by up-regulation of I-A, CD40, CD54 (ICAM-1), CD80 (B7-1), and CD86 (B7-2).	Heparitin Sulfate	51-66	CD40 antigen	Mus musculus	132-136
10903769-5	2000	Incubation of immature murine dendritic cells with heparan sulfate induced phenotypic maturation evidenced by up-regulation of I-A, CD40, CD54 (ICAM-1), CD80 (B7-1), and CD86 (B7-2).	Heparitin Sulfate	51-66	intercellular adhesion molecule 1	Mus musculus	138-142
10903769-5	2000	Incubation of immature murine dendritic cells with heparan sulfate induced phenotypic maturation evidenced by up-regulation of I-A, CD40, CD54 (ICAM-1), CD80 (B7-1), and CD86 (B7-2).	Heparitin Sulfate	51-66	intercellular adhesion molecule 1	Mus musculus	144-150
10903769-5	2000	Incubation of immature murine dendritic cells with heparan sulfate induced phenotypic maturation evidenced by up-regulation of I-A, CD40, CD54 (ICAM-1), CD80 (B7-1), and CD86 (B7-2).	Heparitin Sulfate	51-66	CD80 antigen	Mus musculus	153-157
10903769-5	2000	Incubation of immature murine dendritic cells with heparan sulfate induced phenotypic maturation evidenced by up-regulation of I-A, CD40, CD54 (ICAM-1), CD80 (B7-1), and CD86 (B7-2).	Heparitin Sulfate	51-66	CD86 antigen	Mus musculus	170-174
10903769-7	2000	Stimulation of dendritic cells with heparan sulfate induced release of TNF-alpha, IL-1beta, and IL-6, although the maturation of dendritic cells was independent of these cytokines.	Heparitin Sulfate	36-51	tumor necrosis factor	Mus musculus	71-80
10903769-7	2000	Stimulation of dendritic cells with heparan sulfate induced release of TNF-alpha, IL-1beta, and IL-6, although the maturation of dendritic cells was independent of these cytokines.	Heparitin Sulfate	36-51	interleukin 1 beta	Mus musculus	82-90
10903769-7	2000	Stimulation of dendritic cells with heparan sulfate induced release of TNF-alpha, IL-1beta, and IL-6, although the maturation of dendritic cells was independent of these cytokines.	Heparitin Sulfate	36-51	interleukin 6	Mus musculus	96-100
10878610-3	2000	The EXT1 and EXT2 genes have been cloned and defined as glycosyltransferases involved in the synthesis of heparan sulfate.	Heparitin Sulfate	106-121	exostosin glycosyltransferase 1	Mus musculus	4-8
10878610-3	2000	The EXT1 and EXT2 genes have been cloned and defined as glycosyltransferases involved in the synthesis of heparan sulfate.	Heparitin Sulfate	106-121	exostosin glycosyltransferase 2	Mus musculus	13-17
10963998-1	2000	Decorin and glypican are two examples of exclusively chondroitin/dermatan sulfate and heparan sulfate-substituted proteoglycans, respectively.	Heparitin Sulfate	86-101	glypican 1	Homo sapiens	12-20
10963998-11	2000	Studies on glypican-1 glycoforms that recycle suggest that heparan sulfate chains are degraded by endoheparanase at or near GlcNH(2) residues, followed by deaminative cleavage catalysed by NO-derived nitrite.	Heparitin Sulfate	59-74	glypican 1	Homo sapiens	11-21
10861096-0	2000	Heparan sulfate-like proteoglycans mediate adhesion of human malignant melanoma A375 cells to P-selectin under flow.	Heparitin Sulfate	0-15	selectin P	Homo sapiens	94-104
10861096-8	2000	Further, we found that P-selectin could bind specifically to human tongue squamous cancer Tca-8113 cells, which had negative staining of SLex but positive staining of heparan sulfates.	Heparitin Sulfate	167-183	selectin P	Homo sapiens	23-33
10861096-10	2000	Our results thus indicate that heparan sulfate-like proteoglycans can mediate adhesion of certain types of non-blood borne, "epithelial-like" human cancer cells to P-selectin.	Heparitin Sulfate	31-46	selectin P	Homo sapiens	164-174
10843884-7	2000	However, perfusion of control and diabetic rats with heparinase indicated that diabetic hearts had larger amounts of LPL bound to heparan sulfate proteoglycan-binding sites.	Heparitin Sulfate	130-145	lipoprotein lipase	Rattus norvegicus	117-120
10881022-12	2000	FGF-2 can bind to heparin sulfate chains within the extracellular matrix (ECM).	Heparitin Sulfate	18-33	fibroblast growth factor 2	Homo sapiens	0-5
10860838-7	2000	Ig modules II and III cooperate both within monomers and across dimers with cellular heparan sulfates to confer cell type-dependent specificity of the FGFR complex for FGF.	Heparitin Sulfate	85-101	fibroblast growth factor receptor 2	Homo sapiens	151-155
10843750-4	2000	We found that cell surface heparan sulfate, which binds IFN-gamma, delayed the nuclear accumulation of IFN-gamma suggesting that these molecules serve as storage depot around the cell for local delivery of the cytokine.	Heparitin Sulfate	27-42	interferon gamma	Homo sapiens	56-65
10843750-4	2000	We found that cell surface heparan sulfate, which binds IFN-gamma, delayed the nuclear accumulation of IFN-gamma suggesting that these molecules serve as storage depot around the cell for local delivery of the cytokine.	Heparitin Sulfate	27-42	interferon gamma	Homo sapiens	103-112
10818207-1	2000	Sulphamidase is an exoglycosidase involved in the degradation of heparan sulfate.	Heparitin Sulfate	65-80	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	0-12
10838166-7	2000	These results suggest that OSF is a highly sulfated unique polysaccharide that can promote the binding of bFGF to the heparan sulfate molecules required for binding to the high affinity receptors with tyrosine kinase activity.	Heparitin Sulfate	118-133	fibroblast growth factor 2	Homo sapiens	106-110
10814699-0	2000	A novel role for nitric oxide in the endogenous degradation of heparan sulfate during recycling of glypican-1 in vascular endothelial cells.	Heparitin Sulfate	63-78	glypican 1	Homo sapiens	99-109
10814699-8	2000	We propose that, in recycling glypican-1, heparan sulfate chains are cleaved at or near glucosamines with unsubstituted amino groups.	Heparitin Sulfate	42-57	glypican 1	Homo sapiens	30-40
10809780-1	2000	Heparan sulfate-regulated transmembrane tyrosine kinase receptor FGFR4 is the major FGFR isotype in mature hepatocytes.	Heparitin Sulfate	0-15	fibroblast growth factor receptor 4	Mus musculus	65-70
10814714-10	2000	A GPC3 protein that reproduces this mutation is poorly processed and fails to increase the cell surface expression of heparan sulfate, suggesting that this missense mutation is also a loss-of-function mutation.	Heparitin Sulfate	118-133	glypican 3	Homo sapiens	2-6
10809767-0	2000	Structural requirements of heparan sulfate for the binding to the tumor-derived adhesion factor/angiomodulin that induces cord-like structures to ECV-304 human carcinoma cells.	Heparitin Sulfate	27-42	insulin like growth factor binding protein 7	Homo sapiens	66-95
10809767-0	2000	Structural requirements of heparan sulfate for the binding to the tumor-derived adhesion factor/angiomodulin that induces cord-like structures to ECV-304 human carcinoma cells.	Heparitin Sulfate	27-42	insulin like growth factor binding protein 7	Homo sapiens	96-108
10835602-4	2000	The fusion protein (PG-FGF-1), which was expressed in Chinese hamster ovary cells and collected from the conditioned medium, possessed both HS and chondroitin sulfate sugar chains.	Heparitin Sulfate	140-142	fibroblast growth factor 1	Homo sapiens	23-28
10722716-7	2000	This conclusion supports the likely presence of a range of sequences that can bind to and activate antithrombin in the natural heparan sulfates that line the vascular endothelium.	Heparitin Sulfate	127-143	serpin family C member 1	Homo sapiens	99-111
10788472-2	2000	Binding to cell surface heparan sulfate is indispensable for the biological activity of HB-GAM.	Heparitin Sulfate	24-39	pleiotrophin	Homo sapiens	88-94
10764835-2	2000	We have identified a novel cDNA encoding human heparanase, an enzyme thought to cleave heparan sulfate in physiology and disease, and have located the HEP gene on human chromosome 4q21.	Heparitin Sulfate	87-102	heparanase	Homo sapiens	47-57
10764835-2	2000	We have identified a novel cDNA encoding human heparanase, an enzyme thought to cleave heparan sulfate in physiology and disease, and have located the HEP gene on human chromosome 4q21.	Heparitin Sulfate	87-102	DNL-type zinc finger	Homo sapiens	151-154
10764835-3	2000	Monoclonal antibodies against human heparanase located the enzyme along invasive extravillous trophoblasts of human placenta and along endothelial cells in organ xenografts targeted by hyperacute rejection, both sites of heparan sulfate digestion.	Heparitin Sulfate	221-236	heparanase	Homo sapiens	36-46
10775589-9	2000	Finally, analysis of the biochemical properties of recombinant gp65 revealed a specific interaction with heparin and heparan sulfate proteoglycans and not with closely related molecules such as N-acetylheparin and de-N-sulfated heparin.	Heparitin Sulfate	117-132	neuroplastin	Homo sapiens	63-67
10708453-0	2000	Vaccinia virus envelope H3L protein binds to cell surface heparan sulfate and is important for intracellular mature virion morphogenesis and virus infection in vitro and in vivo.	Heparitin Sulfate	58-73	H3 clustered histone 2	Homo sapiens	24-27
10708453-3	2000	This report demonstrates that soluble H3L protein binds to heparan sulfate on the cell surface and competes with the binding of vaccinia virus, indicating a role for H3L protein in IMV adsorption to mammalian cells.	Heparitin Sulfate	59-74	IMV heparin binding surface protein	Vaccinia virus	38-41
10708453-9	2000	In summary, these data indicate that H3L protein mediates vaccinia virus adsorption to cell surface heparan sulfate and is important for vaccinia virus infection in vitro and in vivo.	Heparitin Sulfate	100-115	IMV heparin binding surface protein	Vaccinia virus	37-40
10775070-1	2000	We have previously shown that the in vivo infusion of interleukin-8 (IL8) in rats causes albuminuria and an increased catabolism of the heparan sulfate (HS) glycosaminoglycans (GAG).	Heparitin Sulfate	136-151	C-X-C motif chemokine ligand 8	Homo sapiens	69-72
10734086-0	2000	Heparan sulfate chains from glypican and syndecans bind the Hep II domain of fibronectin similarly despite minor structural differences.	Heparitin Sulfate	0-15	glypican 1	Homo sapiens	28-36
10734086-0	2000	Heparan sulfate chains from glypican and syndecans bind the Hep II domain of fibronectin similarly despite minor structural differences.	Heparitin Sulfate	0-15	fibronectin 1	Homo sapiens	77-88
10772861-9	2000	Using ELISA plate assays, we demonstrated that peptide 11 and heparan sulfate individually bound to synthetic LBP(205-229) peptide.	Heparitin Sulfate	62-77	galectin 3	Homo sapiens	110-113
10772861-11	2000	These data support the proposal that the 67 kDa LBP can bind the beta-1 laminin chain at the peptide 11 region, and suggest that heparan sulfate is a likely alternate ligand for the binding interactions.	Heparitin Sulfate	129-144	galectin 3	Homo sapiens	48-51
10792372-4	2000	It is known that IFN-gamma can bind cell surface and extracellular heparan sulphate.	Heparitin Sulfate	67-83	interferon gamma	Homo sapiens	17-26
10772816-0	2000	Participation of syndecan 2 in the induction of stress fiber formation in cooperation with integrin alpha5beta1: structural characteristics of heparan sulfate chains with avidity to COOH-terminal heparin-binding domain of fibronectin.	Heparitin Sulfate	143-158	syndecan 2	Mus musculus	17-27
10772816-0	2000	Participation of syndecan 2 in the induction of stress fiber formation in cooperation with integrin alpha5beta1: structural characteristics of heparan sulfate chains with avidity to COOH-terminal heparin-binding domain of fibronectin.	Heparitin Sulfate	143-158	fibronectin 1	Mus musculus	222-233
10772816-1	2000	The present study provides direct evidence that syndecan 2 participates selectively in the induction of stress fiber formation in cooperation with integrin alpha5beta1 through specific binding of its heparan sulfate side chains to the fibronectin substrate.	Heparitin Sulfate	200-215	syndecan 2	Mus musculus	48-58
10772816-1	2000	The present study provides direct evidence that syndecan 2 participates selectively in the induction of stress fiber formation in cooperation with integrin alpha5beta1 through specific binding of its heparan sulfate side chains to the fibronectin substrate.	Heparitin Sulfate	200-215	fibronectin 1	Mus musculus	235-246
10772816-11	2000	All these results consistently suggest that syndecan 2 proteoglycan interacts with the C-terminal heparin-binding domain of fibronectin at the highly sulfated cluster(s), such as [IdoA(2OS)-GlcNS(6OS)](6) present in its heparan sulfate chains, to result in the induction of stress fiber formation in cooperation with integrin alpha5beta1.	Heparitin Sulfate	220-235	syndecan 2	Mus musculus	44-54
10772816-11	2000	All these results consistently suggest that syndecan 2 proteoglycan interacts with the C-terminal heparin-binding domain of fibronectin at the highly sulfated cluster(s), such as [IdoA(2OS)-GlcNS(6OS)](6) present in its heparan sulfate chains, to result in the induction of stress fiber formation in cooperation with integrin alpha5beta1.	Heparitin Sulfate	220-235	fibronectin 1	Mus musculus	124-135
10727403-0	2000	Biosynthesis of heparin/heparan sulphate: mechanism of epimerization of glucuronyl C-5.	Heparitin Sulfate	24-40	complement C5	Bos taurus	83-86
10727403-1	2000	In the biosynthesis of heparin and heparan sulphate, D-glucuronic acid residues are converted into L-iduronic acid (IdoA) units by C-5 epimerization, at the polymer level.	Heparitin Sulfate	35-51	complement C5	Bos taurus	131-134
10810875-3	2000	However, under inflammatory conditions, tumor necrosis factor(TNF)-alpha or other cytokines produced by monocytes reduce the anticoagulant properties of endothelial cell by downregulating expression of heparan sulfate and thrombomodulin on endothelial cells.	Heparitin Sulfate	202-217	tumor necrosis factor	Homo sapiens	40-72
10810875-4	2000	Antithrombin stimulates prostacyclin generation from endothelial cells by interacting with heparan sulfate of endothelial cells and generated prostacyclin inhibits TNF-alpha production by monocytes.	Heparitin Sulfate	91-106	serpin family C member 1	Homo sapiens	0-12
10734053-1	2000	We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) binds to heparan sulfate proteoglycans expressed at the surface of osteoblastic cells and that the mitogenic activity of this cytokine is dependent on the presence of fully sulfated proteoglycans.	Heparitin Sulfate	93-108	colony stimulating factor 2	Homo sapiens	26-74
10734053-1	2000	We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) binds to heparan sulfate proteoglycans expressed at the surface of osteoblastic cells and that the mitogenic activity of this cytokine is dependent on the presence of fully sulfated proteoglycans.	Heparitin Sulfate	93-108	colony stimulating factor 2	Homo sapiens	76-82
10713114-0	2000	Heparan sulfate proteoglycan isoforms of the CD44 hyaluronan receptor induced in human inflammatory macrophages can function as paracrine regulators of fibroblast growth factor action.	Heparitin Sulfate	0-15	CD44 molecule (Indian blood group)	Homo sapiens	45-49
10671486-0	2000	Elucidation of the structural features of heparan sulfate important for interaction with the Hep-2 domain of fibronectin.	Heparitin Sulfate	42-57	fibronectin 1	Homo sapiens	109-120
10699487-3	2000	A preliminary biochemical and structural approach indicated that cell surface proteoglycans are mostly heparan sulfate (HSPG) in immature rat Sertoli cells.	Heparitin Sulfate	103-118	syndecan 1	Rattus norvegicus	120-124
10698186-6	2000	In contrast, both heparin and heparan sulfate significantly inhibited the OPN-IGFBP-5 interaction and chondroitin sulfate A, B, and C had no effect.	Heparitin Sulfate	30-45	secreted phosphoprotein 1	Homo sapiens	74-77
10698186-6	2000	In contrast, both heparin and heparan sulfate significantly inhibited the OPN-IGFBP-5 interaction and chondroitin sulfate A, B, and C had no effect.	Heparitin Sulfate	30-45	insulin like growth factor binding protein 5	Homo sapiens	78-85
10679296-5	2000	Taken together with the recent finding that EXTs encode for the glycosyltransferase required for the synthesis of heparan sulfate [Lind, T., Tufaro, F., McCormick, C., Lindahl, U., and Lindholt, K. (1998) J. Biol.	Heparitin Sulfate	114-129	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	64-83
10671486-2	2000	The major heparan sulfate-binding site in fibronectin, which is also implicated in these morphological events, is the COOH-terminal Hep-2 domain.	Heparitin Sulfate	10-25	fibronectin 1	Homo sapiens	42-53
10684625-2	2000	The interaction of bFGF with heparan sulfate on the cell surface has been demonstrated to impact receptor binding and biological activity.	Heparitin Sulfate	29-44	fibroblast growth factor 2	Mus musculus	19-23
10684625-3	2000	bFGF receptor binding affinity is reduced on cells that do not express heparan sulfate.	Heparitin Sulfate	71-86	fibroblast growth factor 2	Mus musculus	0-4
10684625-4	2000	The addition of soluble heparin or heparan sulfate has been demonstrated to rescue the bFGF receptor binding affinity on heparan sulfate deficient cells yet has also been shown to inhibit binding under some conditions.	Heparitin Sulfate	35-50	fibroblast growth factor 2	Mus musculus	87-91
10684625-4	2000	The addition of soluble heparin or heparan sulfate has been demonstrated to rescue the bFGF receptor binding affinity on heparan sulfate deficient cells yet has also been shown to inhibit binding under some conditions.	Heparitin Sulfate	121-136	fibroblast growth factor 2	Mus musculus	87-91
10684625-8	2000	Low concentrations of heparin (0.1-30 nM) enhanced bFGF receptor binding to an extent that was inversely proportional to the amount of endogenous heparan sulfate sites present.	Heparitin Sulfate	146-161	fibroblast growth factor 2	Mus musculus	51-55
10642607-1	2000	The D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate was investigated with focus on its substrate specificity, its kinetic properties, and a comparison of epimerase preparations from the Furth mastocytoma and bovine liver, which synthesize heparin and heparan sulfate, respectively.	Heparitin Sulfate	74-89	glucuronic acid epimerase	Bos taurus	4-29
10655030-7	2000	The establishment of a role for heparan sulfate in FGFR activation in vivo suggests that tissue-specific differences in the structure of heparan may modulate the activity of FGF.	Heparitin Sulfate	32-47	breathless	Drosophila melanogaster	51-55
10706141-6	2000	In organ culture, the antagonist of FGF binding to a low-affinity fibroblast growth factor receptor (FGFR) heparan sulfate, inositolhexakisphosphate (InsP6), inhibited migration as well.	Heparitin Sulfate	107-122	inositol hexaphosphate kinase 1	Mus musculus	150-155
10642607-1	2000	The D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate was investigated with focus on its substrate specificity, its kinetic properties, and a comparison of epimerase preparations from the Furth mastocytoma and bovine liver, which synthesize heparin and heparan sulfate, respectively.	Heparitin Sulfate	289-304	glucuronic acid epimerase	Bos taurus	4-29
10660581-11	2000	Binding of MMP-7 and other MMPs to heparan sulfate in the extracellular space could prevent loss of secreted enzyme, provide a reservoir of latent enzyme, and facilitate cellular sensing and regulation of enzyme levels.	Heparitin Sulfate	35-50	matrix metallopeptidase 7	Rattus norvegicus	11-16
10660581-11	2000	Binding of MMP-7 and other MMPs to heparan sulfate in the extracellular space could prevent loss of secreted enzyme, provide a reservoir of latent enzyme, and facilitate cellular sensing and regulation of enzyme levels.	Heparitin Sulfate	35-50	matrix metallopeptidase 2	Rattus norvegicus	27-31
10652015-4	2000	With recently developed antibodies directed against the GBM HSPG (agrin) core protein and the HS side chain, we demonstrated a decrease in HS staining in the GBM in different human proteinuric glomerulopathies, such as systemic lupus erythematosus (SLE), minimal change disease, membranous glomerulonephritis, and diabetic nephropathy, whereas the staining of the agrin core protein remained unaltered.	Heparitin Sulfate	60-62	agrin	Homo sapiens	66-71
10687947-1	2000	Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types.	Heparitin Sulfate	99-114	fibroblast growth factor 2	Homo sapiens	0-26
10687947-1	2000	Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types.	Heparitin Sulfate	99-114	fibroblast growth factor 2	Homo sapiens	28-33
10687947-8	2000	The possibility that FGF-2 activity can be manipulated through alterations in heparan sulfate-binding is currently being exploited in the development of clinical applications aimed at modulating either endogenous or administered FGF-2 activity.	Heparitin Sulfate	78-93	fibroblast growth factor 2	Homo sapiens	21-26
10687947-8	2000	The possibility that FGF-2 activity can be manipulated through alterations in heparan sulfate-binding is currently being exploited in the development of clinical applications aimed at modulating either endogenous or administered FGF-2 activity.	Heparitin Sulfate	78-93	fibroblast growth factor 2	Homo sapiens	229-234
10681410-15	2000	In the cell-binding assay, heparan sulfate-binding affinity equal to that of LPL was seen for the RHL chimera mutant that possessed the Cluster 4 sequence of LPL.	Heparitin Sulfate	27-42	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	158-161
10652015-13	2000	Third, in vivo renal perfusion of purified elastase led to a decrease of HS in the GBM caused by proteolytic cleavage of the agrin core protein near the attachment sites of HS by the HS-bound enzyme.	Heparitin Sulfate	73-75	agrin	Homo sapiens	125-130
10652015-13	2000	Third, in vivo renal perfusion of purified elastase led to a decrease of HS in the GBM caused by proteolytic cleavage of the agrin core protein near the attachment sites of HS by the HS-bound enzyme.	Heparitin Sulfate	173-175	agrin	Homo sapiens	125-130
10652015-13	2000	Third, in vivo renal perfusion of purified elastase led to a decrease of HS in the GBM caused by proteolytic cleavage of the agrin core protein near the attachment sites of HS by the HS-bound enzyme.	Heparitin Sulfate	173-175	agrin	Homo sapiens	125-130
10673367-2	2000	When these cells are cultured in the presence of chlorate, an inhibitor of heparan sulfate (HS) sulfation, their proliferation is stimulated by both FGF-1 and FGF-2.	Heparitin Sulfate	75-90	fibroblast growth factor 1	Homo sapiens	149-154
10673326-1	2000	Agrin is an extracellular matrix heparan sulfate proteoglycan (HSPG) well known for its role in modulation of the neuromuscular junction during development.	Heparitin Sulfate	33-48	agrin	Homo sapiens	0-5
10673326-4	2000	Agrin protein binds the amyloidogenic peptide Abeta (1-40) in its fibrillar state via a mechanism that involves the heparan sulfate glycosaminoglycan chains of agrin.	Heparitin Sulfate	116-131	agrin	Homo sapiens	0-5
10673326-4	2000	Agrin protein binds the amyloidogenic peptide Abeta (1-40) in its fibrillar state via a mechanism that involves the heparan sulfate glycosaminoglycan chains of agrin.	Heparitin Sulfate	116-131	amyloid beta precursor protein	Homo sapiens	46-51
10673326-4	2000	Agrin protein binds the amyloidogenic peptide Abeta (1-40) in its fibrillar state via a mechanism that involves the heparan sulfate glycosaminoglycan chains of agrin.	Heparitin Sulfate	116-131	agrin	Homo sapiens	160-165
10648661-9	2000	Enzyme digestion studies demonstrated that the synthesis of both chondroitin sulphate PG (CSPG) and heparan sulphate PG (HSPG) was enhanced as was the production of the core proteins of versican (a large CSPG), perlecan (a basement membrane HSPG) and to a lesser extent decorin (a small dermatan sulphate PG (DSPG)).	Heparitin Sulfate	100-116	syndecan 2	Homo sapiens	121-125
11150731-7	2000	ApoE and apoE-HDL, in contrast, increase perlecan core protein as well as sulfation of heparan sulfate.	Heparitin Sulfate	87-102	apolipoprotein E	Homo sapiens	0-4
11150731-7	2000	ApoE and apoE-HDL, in contrast, increase perlecan core protein as well as sulfation of heparan sulfate.	Heparitin Sulfate	87-102	apolipoprotein E	Homo sapiens	9-13
10673367-0	2000	Differential regulation of FGF-1 and -2 mitogenic activity is related to their kinetics of binding to heparan sulfate in MDA-MB-231 human breast cancer cells.	Heparitin Sulfate	102-117	fibroblast growth factor 1	Homo sapiens	27-39
10673367-2	2000	When these cells are cultured in the presence of chlorate, an inhibitor of heparan sulfate (HS) sulfation, their proliferation is stimulated by both FGF-1 and FGF-2.	Heparitin Sulfate	75-90	fibroblast growth factor 2	Homo sapiens	159-164
10673367-2	2000	When these cells are cultured in the presence of chlorate, an inhibitor of heparan sulfate (HS) sulfation, their proliferation is stimulated by both FGF-1 and FGF-2.	Heparitin Sulfate	92-94	fibroblast growth factor 1	Homo sapiens	149-154
10673367-2	2000	When these cells are cultured in the presence of chlorate, an inhibitor of heparan sulfate (HS) sulfation, their proliferation is stimulated by both FGF-1 and FGF-2.	Heparitin Sulfate	92-94	fibroblast growth factor 2	Homo sapiens	159-164
10639137-0	2000	The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate.	Heparitin Sulfate	138-153	exostosin glycosyltransferase 1	Homo sapiens	31-35
10639137-0	2000	The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate.	Heparitin Sulfate	138-153	exostosin glycosyltransferase 2	Homo sapiens	40-44
10639137-2	2000	The proteins encoded by these genes, EXT1 and EXT2, are endoplasmic reticulum-localized type II transmembrane glycoproteins that possess or are tightly associated with glycosyltransferase activities involved in the polymerization of heparan sulfate.	Heparitin Sulfate	233-248	exostosin glycosyltransferase 1	Homo sapiens	37-41
10639137-2	2000	The proteins encoded by these genes, EXT1 and EXT2, are endoplasmic reticulum-localized type II transmembrane glycoproteins that possess or are tightly associated with glycosyltransferase activities involved in the polymerization of heparan sulfate.	Heparitin Sulfate	233-248	exostosin glycosyltransferase 2	Homo sapiens	46-50
10965119-1	2000	Human EXTL2 is an alpha1,4-N-acetylhexosaminyltransferase involved in the biosynthesis of heparin/heparan sulfate.	Heparitin Sulfate	98-113	exostosin-like glycosyltransferase 2	Mus musculus	6-11
10625699-8	2000	Specifically, TGF-beta(1) induced an accumulation of small chondroitin/dermatan sulfate PGs (CS/DSPGs) with core proteins of approximately 50 kDa in the medium of both dense and sparse cultures, but a cell layer-associated heparan sulfate PG with a core protein size of approximately 400 kDa accumulated only in dense cultures.	Heparitin Sulfate	223-238	transforming growth factor beta 1	Bos taurus	14-25
10625699-10	2000	The heparan sulfate PG and CS/DSPG core proteins were identified as perlecan and biglycan, respectively, by Western blot analysis.	Heparitin Sulfate	4-19	biglycan	Bos taurus	81-89
10608507-5	2000	Binding sites in the SAA protein for high density lipoproteins, calcium, laminin, and heparin/heparan-sulfate were described.	Heparitin Sulfate	94-109	serum amyloid A1 cluster	Homo sapiens	21-24
11097204-7	2000	In the third part the interaction of heparan sulfate chains with fibroblast growth factor-2 (FGF-2, basic FGF) as a prototype example for the interaction of heparin-binding cytokines with heparan sulfate proteoglycans is presented to illustrate the different levels of mutual dependence of the cytokine network and the ECM.	Heparitin Sulfate	37-52	fibroblast growth factor 2	Homo sapiens	65-91
10654598-4	2000	The acceleration of blastocyst differentiation by HB-EGF was attenuated after inhibition of protein tyrosine kinase activity or removal of surface heparan sulfate, as expected.	Heparitin Sulfate	147-162	heparin-binding EGF-like growth factor	Mus musculus	50-56
11097204-7	2000	In the third part the interaction of heparan sulfate chains with fibroblast growth factor-2 (FGF-2, basic FGF) as a prototype example for the interaction of heparin-binding cytokines with heparan sulfate proteoglycans is presented to illustrate the different levels of mutual dependence of the cytokine network and the ECM.	Heparitin Sulfate	37-52	fibroblast growth factor 2	Homo sapiens	93-98
10608853-10	1999	These results demonstrate that syndecan-3 expression is down-regulated during differentiation and the level of expression of membrane-bound heparan sulfate on myoblast surface is critical for fine modulation of responsiveness to FGF-2.	Heparitin Sulfate	140-155	fibroblast growth factor 2	Homo sapiens	229-234
10629596-8	2000	Platelet factor 4 (PF4) displaced from endothelial heparan sulphate or directly from the platelets, binds to the heparin molecule to form an immunogenic complex.	Heparitin Sulfate	51-67	platelet factor 4	Homo sapiens	0-17
10629596-8	2000	Platelet factor 4 (PF4) displaced from endothelial heparan sulphate or directly from the platelets, binds to the heparin molecule to form an immunogenic complex.	Heparitin Sulfate	51-67	platelet factor 4	Homo sapiens	19-22
10651945-1	2000	We have found previously that disaccharides (DS) enzymatically generated from heparin or heparan sulphate can modulate tumour necrosis factor-alpha (TNF-alpha) secretion from immune cells in vitro and cell-mediated immune reactions in vivo.	Heparitin Sulfate	89-105	tumor necrosis factor	Homo sapiens	149-158
10651945-3	2000	We found that certain heparin- and heparan sulphate-derived DS induced, in a dose-dependent manner, the adhesion of human T cells to both extracellular matrix (ECM) and immobilized fibronectin (FN); maximal T-cell adhesion occurred with 1 ng/ml of DS.	Heparitin Sulfate	35-51	fibronectin 1	Homo sapiens	181-192
10651945-3	2000	We found that certain heparin- and heparan sulphate-derived DS induced, in a dose-dependent manner, the adhesion of human T cells to both extracellular matrix (ECM) and immobilized fibronectin (FN); maximal T-cell adhesion occurred with 1 ng/ml of DS.	Heparitin Sulfate	35-51	fibronectin 1	Homo sapiens	194-196
10679527-3	2000	In particular, the collagen-like domain of ColQ contains two heparin-binding domains which interact with heparan sulfate proteoglycans in the basal lamina.	Heparitin Sulfate	105-120	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	43-47
10627288-2	2000	The heparan sulfate chains (HS) mediate stable high affinity binding of FGFs to their receptor tyrosine kinases (FR) and may specifically regulate FGF activity.	Heparitin Sulfate	4-19	fibroblast growth factor 2	Homo sapiens	72-75
10627288-7	2000	Apparently, basement membrane and cell surface HSPGs differ in their ability to mediate the assembly of a FGF/FR signaling complex presumably due to structural differences of the heparan sulfate chains.	Heparitin Sulfate	179-194	fibroblast growth factor 2	Homo sapiens	106-109
10714610-10	2000	CONCLUSIONS: These results suggest that 125I-bFGF is transported across the BBB, possibly by an adsorptive-mediated transcytosis mechanism that is triggered by binding to negatively charged species on the luminal membrane surface of the brain microvasculature, such as heparan sulfate proteoglycans.	Heparitin Sulfate	269-284	fibroblast growth factor 2	Bos taurus	45-49
10601255-11	1999	In addition to TF, other cell surface components, such as low density lipoprotein receptor-related protein (LRP) and heparan sulfates, are essential for TFPI.Xa-induced internalization of FVIIa.	Heparitin Sulfate	117-133	tissue factor pathway inhibitor	Homo sapiens	153-157
10585884-7	1999	Western blot analysis showed expression of GPC-4 as a heparan sulphate proteoglycan in the human haematopoietic-progenitor cell line TF-1 and normal human bone marrow.	Heparitin Sulfate	54-70	glypican 4	Homo sapiens	43-48
10593935-3	1999	We recently showed that apoE stimulates endothelial production of heparan sulfate (HS) enriched in heparin-like sequences.	Heparitin Sulfate	66-81	apolipoprotein E	Homo sapiens	24-28
10593935-3	1999	We recently showed that apoE stimulates endothelial production of heparan sulfate (HS) enriched in heparin-like sequences.	Heparitin Sulfate	83-85	apolipoprotein E	Homo sapiens	24-28
10595940-1	1999	Heparan sulfate proteoglycans (HSPGs) have been suggested to play an important role in the formation and persistence of senile plaques and neurofibrillary tangles in dementia of the Alzheimer"s type (DAT).	Heparitin Sulfate	0-15	solute carrier family 6 member 3	Homo sapiens	200-203
10588735-1	1999	The Sanfilippo syndrome type B is an autosomal recessive disorder caused by mutation in the gene (NAGLU) encoding alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate.	Heparitin Sulfate	205-220	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	98-103
10588735-1	1999	The Sanfilippo syndrome type B is an autosomal recessive disorder caused by mutation in the gene (NAGLU) encoding alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate.	Heparitin Sulfate	205-220	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	114-143
10630505-2	1999	The purpose of this study was to investigate the hypothesis that heparin functions as a coreceptor molecule for basic fibroblast growth factor, a role usually performed by heparan sulfate chains on syndecan-1.	Heparitin Sulfate	172-187	syndecan 1	Homo sapiens	198-208
10527823-2	1999	Recent studies have revealed that HGF is trapped in the extracellular (ECM) matrix through heparan sulphate in vivo, thereby acting as a mitogen for hepatocytes in cooperation with heparan sulphate.	Heparitin Sulfate	91-107	hepatocyte growth factor	Homo sapiens	34-37
10556044-4	1999	Heparan sulphate attached to this site was shown to bind to the alpha1LG4 module of laminin-1, indicating a role in basement membrane assembly and cell-matrix interactions.	Heparitin Sulfate	0-16	adrenoceptor alpha 1D	Homo sapiens	64-73
10562536-0	1999	Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin.	Heparitin Sulfate	47-62	collagen type XVIII alpha 1 chain	Homo sapiens	101-111
10562536-3	1999	The same epitopes also participate in endostatin binding to heparan sulfate and sulfatides but not in its binding to the extracellular protein ligands fibulin-1 and fibulin-2.	Heparitin Sulfate	60-75	collagen type XVIII alpha 1 chain	Homo sapiens	38-48
10562536-5	1999	Furthermore, a substantial proportion (10-50%) of heparan sulfate chains obtained from various tissues showed a distinct binding to endostatin, indicating its potential to interact with extracellular and/or membrane-bound proteoglycans.	Heparitin Sulfate	50-65	collagen type XVIII alpha 1 chain	Homo sapiens	132-142
10527946-2	1999	The two main groups of proteoglycans which contain heparan sulphate chains are members of the syndecan and glypican families.	Heparitin Sulfate	51-67	syndecan 1	Homo sapiens	94-102
10630202-0	1999	Heparan sulfate in the inner limiting membrane of embryonic chicken retina binds basic fibroblast growth factor to promote axonal outgrowth.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Gallus gallus	81-111
10630202-9	1999	These results demonstrate that HS in the ILM possesses neurotropic activity for axons of the ganglion cells by binding bFGF for presentation to cell-surface receptors and may, therefore, play a significant role in stimulating axonal outgrowth during development.	Heparitin Sulfate	31-33	fibroblast growth factor 2	Gallus gallus	119-123
10502291-0	1999	Identification of cell-binding site of angiomodulin (AGM/TAF/Mac25) that interacts with heparan sulfates on cell surface.	Heparitin Sulfate	88-104	insulin like growth factor binding protein 7	Homo sapiens	39-51
10502291-0	1999	Identification of cell-binding site of angiomodulin (AGM/TAF/Mac25) that interacts with heparan sulfates on cell surface.	Heparitin Sulfate	88-104	insulin like growth factor binding protein 7	Homo sapiens	57-60
10502291-0	1999	Identification of cell-binding site of angiomodulin (AGM/TAF/Mac25) that interacts with heparan sulfates on cell surface.	Heparitin Sulfate	88-104	insulin like growth factor binding protein 7	Homo sapiens	61-66
10529789-3	1999	HME is usually caused by defects in either one of two genes, EXT1 and EXT2, which encode enzymes that catalyse the biosynthesis of heparan sulphate, an important component of the extracellular matrix.	Heparitin Sulfate	131-147	exostosin glycosyltransferase 1	Homo sapiens	61-65
10529789-3	1999	HME is usually caused by defects in either one of two genes, EXT1 and EXT2, which encode enzymes that catalyse the biosynthesis of heparan sulphate, an important component of the extracellular matrix.	Heparitin Sulfate	131-147	exostosin glycosyltransferase 2	Homo sapiens	70-74
11212344-6	1999	Heparan sulfate has been further implicated in presentation and stabilization of lipoprotein lipase and hepatic lipase on cell surfaces and in the transport of lipoprotein lipase from extravascular cells to the luminal surface of the endothelia.	Heparitin Sulfate	0-15	lipoprotein lipase	Homo sapiens	81-99
11212344-6	1999	Heparan sulfate has been further implicated in presentation and stabilization of lipoprotein lipase and hepatic lipase on cell surfaces and in the transport of lipoprotein lipase from extravascular cells to the luminal surface of the endothelia.	Heparitin Sulfate	0-15	lipase C, hepatic type	Homo sapiens	104-118
11212344-6	1999	Heparan sulfate has been further implicated in presentation and stabilization of lipoprotein lipase and hepatic lipase on cell surfaces and in the transport of lipoprotein lipase from extravascular cells to the luminal surface of the endothelia.	Heparitin Sulfate	0-15	lipoprotein lipase	Homo sapiens	160-178
11212344-8	1999	Heparan sulfate thus binds and regulates the activity of growth factors, cytokines, superoxide dismutase and antithrombin, which contribute to aberrant cell proliferation, migration and matrix production, scavenging of reactive oxygen radicals and thrombosis.	Heparitin Sulfate	0-15	serpin family C member 1	Homo sapiens	109-121
10555961-2	1999	Heparin or closely related heparan sulfate has profound effects on HGF signaling.	Heparitin Sulfate	27-42	hepatocyte growth factor	Homo sapiens	67-70
10583162-1	1999	Previous in vitro studies have shown CD44 isoforms containing the alternatively spliced exon v3 (CD44v3) to be modified with heparan sulphate (HS) and to bind HS-binding basic fibroblast growth factor (bFGF).	Heparitin Sulfate	125-141	CD44 molecule (Indian blood group)	Homo sapiens	37-41
10583162-1	1999	Previous in vitro studies have shown CD44 isoforms containing the alternatively spliced exon v3 (CD44v3) to be modified with heparan sulphate (HS) and to bind HS-binding basic fibroblast growth factor (bFGF).	Heparitin Sulfate	143-145	CD44 molecule (Indian blood group)	Homo sapiens	37-41
10527823-2	1999	Recent studies have revealed that HGF is trapped in the extracellular (ECM) matrix through heparan sulphate in vivo, thereby acting as a mitogen for hepatocytes in cooperation with heparan sulphate.	Heparitin Sulfate	181-197	hepatocyte growth factor	Homo sapiens	34-37
10527823-7	1999	These observations suggest that HGF can be trapped in ECM in vivo, thereby acting as a mitogen for cytotrophoblasts and placental vein endothelial cells in cooperation with heparan sulphate.	Heparitin Sulfate	173-189	hepatocyte growth factor	Homo sapiens	32-35
10490977-0	1999	Regulation of T cell homeostasis by heparan sulfate-bound IL-2.	Heparitin Sulfate	36-51	interleukin 2	Mus musculus	58-62
10521448-0	1999	Common binding sites for beta-amyloid fibrils and fibroblast growth factor-2 in heparan sulfate from human cerebral cortex.	Heparitin Sulfate	80-95	fibroblast growth factor 2	Homo sapiens	50-76
10521448-1	1999	Heparan sulfate found in the cerebral plaques of Alzheimer"s disease binds to beta-amyloid (Abeta) fibrils.	Heparitin Sulfate	0-15	amyloid beta precursor protein	Homo sapiens	92-97
10521448-3	1999	On the other hand, heparan sulfate augments signaling of fibroblast growth factor-2 (FGF-2), a neuroprotective factor that antagonizes the neurotoxic effects of Abeta.	Heparitin Sulfate	19-34	fibroblast growth factor 2	Homo sapiens	57-83
10521448-3	1999	On the other hand, heparan sulfate augments signaling of fibroblast growth factor-2 (FGF-2), a neuroprotective factor that antagonizes the neurotoxic effects of Abeta.	Heparitin Sulfate	19-34	fibroblast growth factor 2	Homo sapiens	85-90
10521448-3	1999	On the other hand, heparan sulfate augments signaling of fibroblast growth factor-2 (FGF-2), a neuroprotective factor that antagonizes the neurotoxic effects of Abeta.	Heparitin Sulfate	19-34	amyloid beta precursor protein	Homo sapiens	161-166
10521448-4	1999	We defined structures in heparan sulfate from human cerebral cortex that bind Abeta fibrils.	Heparitin Sulfate	25-40	amyloid beta precursor protein	Homo sapiens	78-83
10521448-7	1999	The binding specificity of fibrillar Abeta is shared by FGF-2, and we here show that cerebral heparan sulfate domains selected for binding to Abeta-(1-40) fibrils bind also to FGF-2.	Heparitin Sulfate	94-109	amyloid beta precursor protein	Homo sapiens	37-42
10521448-7	1999	The binding specificity of fibrillar Abeta is shared by FGF-2, and we here show that cerebral heparan sulfate domains selected for binding to Abeta-(1-40) fibrils bind also to FGF-2.	Heparitin Sulfate	94-109	fibroblast growth factor 2	Homo sapiens	56-61
10521448-7	1999	The binding specificity of fibrillar Abeta is shared by FGF-2, and we here show that cerebral heparan sulfate domains selected for binding to Abeta-(1-40) fibrils bind also to FGF-2.	Heparitin Sulfate	94-109	amyloid beta precursor protein	Homo sapiens	142-147
10521448-7	1999	The binding specificity of fibrillar Abeta is shared by FGF-2, and we here show that cerebral heparan sulfate domains selected for binding to Abeta-(1-40) fibrils bind also to FGF-2.	Heparitin Sulfate	94-109	fibroblast growth factor 2	Homo sapiens	176-181
10512728-1	1999	Fibroblast growth factor-4 (FGF4), like other FGFs, shares a high affinity for the anionic glycosaminoglycans heparin and heparan sulfate (HS), which in turn enhance FGF-receptor (FGFR) binding and activation.	Heparitin Sulfate	122-137	fibroblast growth factor 4	Homo sapiens	0-26
10512728-1	1999	Fibroblast growth factor-4 (FGF4), like other FGFs, shares a high affinity for the anionic glycosaminoglycans heparin and heparan sulfate (HS), which in turn enhance FGF-receptor (FGFR) binding and activation.	Heparitin Sulfate	122-137	fibroblast growth factor 4	Homo sapiens	28-32
10512728-1	1999	Fibroblast growth factor-4 (FGF4), like other FGFs, shares a high affinity for the anionic glycosaminoglycans heparin and heparan sulfate (HS), which in turn enhance FGF-receptor (FGFR) binding and activation.	Heparitin Sulfate	139-141	fibroblast growth factor 4	Homo sapiens	0-26
10512728-1	1999	Fibroblast growth factor-4 (FGF4), like other FGFs, shares a high affinity for the anionic glycosaminoglycans heparin and heparan sulfate (HS), which in turn enhance FGF-receptor (FGFR) binding and activation.	Heparitin Sulfate	139-141	fibroblast growth factor 4	Homo sapiens	28-32
10504408-6	1999	The phosphodiesterase/pyrophosphatase activity of PC-1 was competitively inhibited by glycosaminoglycans, such as heparin and heparan sulfate, which are the major components of the extracellular matrix.	Heparitin Sulfate	126-141	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	50-54
10572947-4	1999	Besides these quantitative effects, activation of protein kinase C by PMA induced qualitative changes as reflected by increase in relative proportion of heparan sulfate PG (HSPG) in cell membrane PG.	Heparitin Sulfate	153-168	syndecan 2	Rattus norvegicus	173-177
10490977-4	1999	Here we show that an association between IL-2 and heparan sulfate localizes IL-2 to lymphoid organs such as the spleen.	Heparitin Sulfate	50-65	interleukin 2	Mus musculus	41-45
10490977-4	1999	Here we show that an association between IL-2 and heparan sulfate localizes IL-2 to lymphoid organs such as the spleen.	Heparitin Sulfate	50-65	interleukin 2	Mus musculus	76-80
10482629-1	1999	We previously showed that an envelope A27L protein of intracellular mature virions (IMV) of vaccinia virus binds to cell surface heparan sulfate during virus infection.	Heparitin Sulfate	129-144	IMV surface protein	Vaccinia virus	38-42
10863479-5	1999	Considering these results together with our previous report, we found that the cell-surface heparan sulfate proteoglycans, syndecan-1, syndecan-2, syndecan-4 and glypican, are synthesized in the monkey submandibular glands, and that their ectodomains are released into the extracellular matrix.	Heparitin Sulfate	92-107	syndecan 1	Homo sapiens	123-133
10863479-5	1999	Considering these results together with our previous report, we found that the cell-surface heparan sulfate proteoglycans, syndecan-1, syndecan-2, syndecan-4 and glypican, are synthesized in the monkey submandibular glands, and that their ectodomains are released into the extracellular matrix.	Heparitin Sulfate	92-107	syndecan 2	Homo sapiens	135-145
10863479-5	1999	Considering these results together with our previous report, we found that the cell-surface heparan sulfate proteoglycans, syndecan-1, syndecan-2, syndecan-4 and glypican, are synthesized in the monkey submandibular glands, and that their ectodomains are released into the extracellular matrix.	Heparitin Sulfate	92-107	syndecan 4	Homo sapiens	147-157
10512861-1	1999	The unc-52 gene encodes the nematode homologue of mammalian perlecan, the major heparan sulfate proteoglycan of the extracellular matrix.	Heparitin Sulfate	80-95	Basement membrane proteoglycan;Ig-like domain-containing protein	Caenorhabditis elegans	4-10
10504268-10	1999	Consistent with this, heparin and heparin sulfate could inhibit IL-8-induced neutrophil calcium flux.	Heparitin Sulfate	34-49	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
10446158-8	1999	Importantly, the amino-terminal domain of SDF-1alpha which is required for binding to, and activation of, CXCR4 remains exposed after binding to HS and is recognized by a neutralizing monoclonal antibody directed against the first residues of the chemokine.	Heparitin Sulfate	145-147	C-X-C motif chemokine receptor 4	Homo sapiens	106-111
10549295-4	1999	In this paper, we present in vivo evidence that ttv is involved in heparan sulfate proteoglycan (HSPG) biosynthesis, suggesting that HSPGs control Hh distribution.	Heparitin Sulfate	67-82	syndecan 2	Homo sapiens	97-101
10433902-5	1999	Consistent with an involvement of Sulfateless and Sugarless in fibroblast growth factor receptor signaling, a constitutively activated form of Heartless partially rescues sugarless and sulfateless mutants, and dosage-sensitive interactions occur between heartless and the heparan sulfate glycosaminoglycan biosynthetic enzyme genes.	Heparitin Sulfate	272-287	breathless	Drosophila melanogaster	63-96
10530949-1	1999	It has been proposed that oligosaccharides corresponding to the so-called regular region of heparin/heparan sulfate (HS) bind to fibroblast growth factor-2 (FGF-2).	Heparitin Sulfate	100-115	fibroblast growth factor 2	Homo sapiens	129-155
10530949-1	1999	It has been proposed that oligosaccharides corresponding to the so-called regular region of heparin/heparan sulfate (HS) bind to fibroblast growth factor-2 (FGF-2).	Heparitin Sulfate	100-115	fibroblast growth factor 2	Homo sapiens	157-162
10496308-5	1999	Heparan sulfate triggered up-regulation of ICAM-1 and I-A, caused the release by antigen-presenting cells of interleukin (IL)-1, IL-6, tumor necrosis factor, IL-12, transforming growth factor beta, and prostaglandin E2 (PGE2), and (in macrophages) induced cytotoxic capability.	Heparitin Sulfate	0-15	intercellular adhesion molecule 1	Homo sapiens	43-49
10496308-5	1999	Heparan sulfate triggered up-regulation of ICAM-1 and I-A, caused the release by antigen-presenting cells of interleukin (IL)-1, IL-6, tumor necrosis factor, IL-12, transforming growth factor beta, and prostaglandin E2 (PGE2), and (in macrophages) induced cytotoxic capability.	Heparitin Sulfate	0-15	interleukin 6	Homo sapiens	129-133
10496308-5	1999	Heparan sulfate triggered up-regulation of ICAM-1 and I-A, caused the release by antigen-presenting cells of interleukin (IL)-1, IL-6, tumor necrosis factor, IL-12, transforming growth factor beta, and prostaglandin E2 (PGE2), and (in macrophages) induced cytotoxic capability.	Heparitin Sulfate	0-15	transforming growth factor beta 1	Homo sapiens	165-196
10446183-0	1999	Inducible expression of the cell surface heparan sulfate proteoglycan syndecan-2 (fibroglycan) on human activated macrophages can regulate fibroblast growth factor action.	Heparitin Sulfate	41-56	syndecan 2	Homo sapiens	70-80
10446183-0	1999	Inducible expression of the cell surface heparan sulfate proteoglycan syndecan-2 (fibroglycan) on human activated macrophages can regulate fibroblast growth factor action.	Heparitin Sulfate	41-56	syndecan 2	Homo sapiens	82-93
10446189-5	1999	Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate and has been implicated in inflammation and tumor angiogenesis and metastasis.	Heparitin Sulfate	63-78	glucuronidase beta	Homo sapiens	22-42
10446158-9	1999	Overall, these findings indicate that the Lys(24), His(25), and Lys(27) cluster of residues forms, or is an essential part of, the HS-binding site which is distinct from that required for binding to, and signaling through, CXCR4.	Heparitin Sulfate	131-133	C-X-C motif chemokine receptor 4	Homo sapiens	223-228
10446222-6	1999	Mutations of heparan sulfate attachment sites on S4 construct abolished syndecan-4-dependent augmentation of bFGF responses.	Heparitin Sulfate	13-28	syndecan 4	Homo sapiens	72-82
10446222-6	1999	Mutations of heparan sulfate attachment sites on S4 construct abolished syndecan-4-dependent augmentation of bFGF responses.	Heparitin Sulfate	13-28	fibroblast growth factor 2	Homo sapiens	109-113
10482449-1	1999	It has been suggested that the FGF-2 binding site on heparan sulfate chains is a trisulfated pentasaccharide containing three hexuronic acid units.	Heparitin Sulfate	53-68	fibroblast growth factor 2	Homo sapiens	31-36
10428080-0	1999	Regulation of the heparan sulfate proteoglycan, perlecan, by injury and interleukin-1alpha.	Heparitin Sulfate	18-33	interleukin 1 alpha	Mus musculus	72-90
10421785-9	1999	Thus HRG can interact with FcgammaRI on monocytes and block monomeric IgG binding, whereas when incorporated in IgG containing IC, HRG can enhance the uptake of IC by monocytes, probably via its heparan sulfate binding domain.	Heparitin Sulfate	195-210	histidine rich glycoprotein	Homo sapiens	131-134
10405343-7	1999	The HSE1 gene product was shown to exhibit heparanase activity by specifically cleaving a labeled heparan sulfate substrate in a similar manner as purified native protein.	Heparitin Sulfate	98-113	heparanase	Homo sapiens	4-8
10400721-0	1999	The furin protease cleavage recognition sequence of Sindbis virus PE2 can mediate virion attachment to cell surface heparan sulfate.	Heparitin Sulfate	116-131	furin, paired basic amino acid cleaving enzyme	Homo sapiens	4-9
10400721-0	1999	The furin protease cleavage recognition sequence of Sindbis virus PE2 can mediate virion attachment to cell surface heparan sulfate.	Heparitin Sulfate	116-131	ETS2 repressor factor	Homo sapiens	66-69
10405343-7	1999	The HSE1 gene product was shown to exhibit heparanase activity by specifically cleaving a labeled heparan sulfate substrate in a similar manner as purified native protein.	Heparitin Sulfate	98-113	heparanase	Homo sapiens	43-53
10393839-2	1999	The mechanism of action is unknown, but the crystal structure of endostatin predicts a prominent heparan sulfate binding site, suggesting that endostatin competitively inhibits heparin-binding angiogenic factors, such as basic fibroblast growth factor (FGF-2).	Heparitin Sulfate	97-112	collagen type XVIII alpha 1 chain	Homo sapiens	65-75
10389767-1	1999	Basic fibroblast growth factor (bFGF) is dependent on heparan sulphate for its ability to activate the cell surface signal transducing receptor.	Heparitin Sulfate	54-70	fibroblast growth factor 2	Homo sapiens	0-30
10389767-1	1999	Basic fibroblast growth factor (bFGF) is dependent on heparan sulphate for its ability to activate the cell surface signal transducing receptor.	Heparitin Sulfate	54-70	fibroblast growth factor 2	Homo sapiens	32-36
10400621-9	1999	This report demonstrates the recruitment of a heparan sulfate to the IL-1 receptor complex, following attachment to fibronectin, which correlates with alterations in receptor function.	Heparitin Sulfate	46-61	interleukin 1 alpha	Homo sapiens	69-73
10400621-9	1999	This report demonstrates the recruitment of a heparan sulfate to the IL-1 receptor complex, following attachment to fibronectin, which correlates with alterations in receptor function.	Heparitin Sulfate	46-61	fibronectin 1	Homo sapiens	116-127
10400621-10	1999	The data suggest that the heparan sulfate constitutes an attachment regulated component of the IL-1 receptor complex with the role of mediating matrix regulation of IL-1 responses.	Heparitin Sulfate	26-41	interleukin 1 alpha	Homo sapiens	95-99
10400621-10	1999	The data suggest that the heparan sulfate constitutes an attachment regulated component of the IL-1 receptor complex with the role of mediating matrix regulation of IL-1 responses.	Heparitin Sulfate	26-41	interleukin 1 alpha	Homo sapiens	165-169
10393839-2	1999	The mechanism of action is unknown, but the crystal structure of endostatin predicts a prominent heparan sulfate binding site, suggesting that endostatin competitively inhibits heparin-binding angiogenic factors, such as basic fibroblast growth factor (FGF-2).	Heparitin Sulfate	97-112	collagen type XVIII alpha 1 chain	Homo sapiens	143-153
10375392-5	1999	The lipid peroxidation and oxidative modification of apoE in VLDL mediated by Cu2+ and an aqueous radical generator were suppressed by GAG, heparan sulfate, heparin, and chondroitin sulfate A, even though GAGs demonstrated no ability to scavenge alpha,alpha-diphenyl-beta-picrylhydrazyl radical.	Heparitin Sulfate	140-155	apolipoprotein E	Homo sapiens	53-57
10362842-0	1999	Characterization of fibroblast growth factor 1 binding heparan sulfate domain.	Heparitin Sulfate	55-70	fibroblast growth factor 1	Homo sapiens	20-46
10362842-1	1999	Fibroblast growth factors FGF-1 and FGF-2 mediate their biological effects via heparan sulfate-dependent interactions with cell surface FGF receptors.	Heparitin Sulfate	79-94	fibroblast growth factor 1	Homo sapiens	26-31
10362842-1	1999	Fibroblast growth factors FGF-1 and FGF-2 mediate their biological effects via heparan sulfate-dependent interactions with cell surface FGF receptors.	Heparitin Sulfate	79-94	fibroblast growth factor 2	Homo sapiens	36-41
10362842-2	1999	While the specific heparan sulfate domain binding to FGF-2 has been elucidated in some detail, limited information has been available concerning heparan sulfate structures involved in the recognition of FGF-1.	Heparitin Sulfate	19-34	fibroblast growth factor 2	Homo sapiens	53-58
10362842-2	1999	While the specific heparan sulfate domain binding to FGF-2 has been elucidated in some detail, limited information has been available concerning heparan sulfate structures involved in the recognition of FGF-1.	Heparitin Sulfate	145-160	fibroblast growth factor 1	Homo sapiens	203-208
10362842-3	1999	In the current study we present evidence that the minimal FGF-1 binding heparan sulfate sequence comprises 5-7 monosaccharide units and contains a critical trisulfated IdoA(2-OSO3)-GlcNSO3(6-OSO3) disaccharide unit.	Heparitin Sulfate	72-87	fibroblast growth factor 1	Homo sapiens	58-63
10362842-6	1999	We further show that the FGF-1 binding heparan sulfate domain is expressed in human aorta heparan sulfate in an age-related manner in contrast to the constitutively expressed FGF-2 binding domain.	Heparitin Sulfate	39-54	fibroblast growth factor 1	Homo sapiens	25-30
10362842-6	1999	We further show that the FGF-1 binding heparan sulfate domain is expressed in human aorta heparan sulfate in an age-related manner in contrast to the constitutively expressed FGF-2 binding domain.	Heparitin Sulfate	90-105	fibroblast growth factor 1	Homo sapiens	25-30
10362842-7	1999	Reduction of heparan sulfate O-sulfation by chlorate treatment of cells selectively impedes binding to FGF-1.	Heparitin Sulfate	13-28	fibroblast growth factor 1	Homo sapiens	103-108
10362842-8	1999	The present data implicate the 6-O-sulfation of IdoA(2-OSO3)-GlcNSO3 units in cellular heparan sulfate in the control of the biological activity of FGF-1.	Heparitin Sulfate	87-102	fibroblast growth factor 1	Homo sapiens	148-153
10354124-1	1999	Soluble heparin displaces the cytokine hepatocyte growth factor (HGF) from heparan sulphate proteoglycans on the cell surface and in the extracellular matrix into the circulation.	Heparitin Sulfate	75-91	hepatocyte growth factor	Homo sapiens	39-63
10373479-7	1999	Expression of this variant syndecan-1 in Madin-Darby canine kidney or MOLT-4 cells yielded a recombinant proteoglycan with a reduced number and clustering of the heparan sulfate chains.	Heparitin Sulfate	162-177	syndecan 1	Canis lupus familiaris	27-37
10378377-9	1999	These findings indicate that tau deposits are antigenically similar in several neurodegenerative diseases and that tau staining is often associated with heparan sulphate staining, supporting the concept that heparan sulphate may be involved in the assembly of tau protein into filaments.	Heparitin Sulfate	208-224	microtubule associated protein tau	Homo sapiens	29-32
10378377-9	1999	These findings indicate that tau deposits are antigenically similar in several neurodegenerative diseases and that tau staining is often associated with heparan sulphate staining, supporting the concept that heparan sulphate may be involved in the assembly of tau protein into filaments.	Heparitin Sulfate	208-224	microtubule associated protein tau	Homo sapiens	115-118
10378377-9	1999	These findings indicate that tau deposits are antigenically similar in several neurodegenerative diseases and that tau staining is often associated with heparan sulphate staining, supporting the concept that heparan sulphate may be involved in the assembly of tau protein into filaments.	Heparitin Sulfate	208-224	microtubule associated protein tau	Homo sapiens	115-118
10410303-1	1999	Lipoprotein lipase (LPL) is known to be attached to the luminal surface of vascular endothelial cells in a complex with membrane-bound heparan sulfate, and released into blood stream by heparin.	Heparitin Sulfate	135-150	lipoprotein lipase	Homo sapiens	0-18
10410303-1	1999	Lipoprotein lipase (LPL) is known to be attached to the luminal surface of vascular endothelial cells in a complex with membrane-bound heparan sulfate, and released into blood stream by heparin.	Heparitin Sulfate	135-150	lipoprotein lipase	Homo sapiens	20-23
10354124-1	1999	Soluble heparin displaces the cytokine hepatocyte growth factor (HGF) from heparan sulphate proteoglycans on the cell surface and in the extracellular matrix into the circulation.	Heparitin Sulfate	75-91	hepatocyte growth factor	Homo sapiens	65-68
10341217-8	1999	Interestingly, although cell responsiveness to hepatocyte growth factor is not restored by exogenous heparan/dermatan sulphate chains, it is by an immobilised heparan sulphate proteoglycan substratum.	Heparitin Sulfate	159-175	hepatocyte growth factor	Canis lupus familiaris	47-71
10545017-4	1999	In this study, we demonstrated that nerve growth factor (NGF), the prototypic NT, and NT-4/5 increased in vitro invasion through a reconstituted basement membrane and induced time- and dose-dependent expression of heparanase, a heparan sulfate-specific endo-beta-D-glucuronidase, an important molecular determinant of tumor metastasis.	Heparitin Sulfate	228-243	nerve growth factor	Homo sapiens	36-55
10545017-4	1999	In this study, we demonstrated that nerve growth factor (NGF), the prototypic NT, and NT-4/5 increased in vitro invasion through a reconstituted basement membrane and induced time- and dose-dependent expression of heparanase, a heparan sulfate-specific endo-beta-D-glucuronidase, an important molecular determinant of tumor metastasis.	Heparitin Sulfate	228-243	nerve growth factor	Homo sapiens	57-60
10328953-3	1999	Our data show that agrin binds FGF-2 and thrombospondin by a heparan sulfate-dependent mechanism, merosin and laminin by both heparan sulfate-dependent and -independent mechanisms, and tenascin solely via agrin"s protein core.	Heparitin Sulfate	61-76	agrin	Gallus gallus	19-24
10336501-2	1999	Here we show that in contrast to heparin, cellular heparan sulfate forms a binary complex with FGFR that discriminates between FGF-1 and FGF-2.	Heparitin Sulfate	51-66	fibroblast growth factor 1	Homo sapiens	127-132
10336501-2	1999	Here we show that in contrast to heparin, cellular heparan sulfate forms a binary complex with FGFR that discriminates between FGF-1 and FGF-2.	Heparitin Sulfate	51-66	fibroblast growth factor 2	Homo sapiens	137-142
10328953-3	1999	Our data show that agrin binds FGF-2 and thrombospondin by a heparan sulfate-dependent mechanism, merosin and laminin by both heparan sulfate-dependent and -independent mechanisms, and tenascin solely via agrin"s protein core.	Heparitin Sulfate	126-141	agrin	Gallus gallus	19-24
10339611-1	1999	Agrin is a heparan sulfate proteoglycan that is widely expressed in neurons and microvascular basal lamina in the rodent and avian central nervous system.	Heparitin Sulfate	11-26	agrin	Homo sapiens	0-5
10328953-4	1999	Furthermore, agrin"s heparan sulfate side chains encode a specificity in interactions with heparin-binding molecules since fibronectin and the cell adhesion molecule L1 do not bind agrin.	Heparitin Sulfate	21-36	agrin	Gallus gallus	13-18
10328953-4	1999	Furthermore, agrin"s heparan sulfate side chains encode a specificity in interactions with heparin-binding molecules since fibronectin and the cell adhesion molecule L1 do not bind agrin.	Heparitin Sulfate	21-36	fibronectin 1	Gallus gallus	123-134
10328956-4	1999	The attachment of both SK-N-SH and U-251MG cells to TSP-1 was found to be mediated by heparan sulfate proteoglycans, integrins, and the CLESH-1 adhesion domain first identified in CD36.	Heparitin Sulfate	86-101	thrombospondin 1	Homo sapiens	52-57
10328871-3	1999	A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs.	Heparitin Sulfate	28-43	interferon gamma	Homo sapiens	172-181
10229666-0	1999	An IKLLI-containing peptide derived from the laminin alpha1 chain mediating heparin-binding, cell adhesion, neurite outgrowth and proliferation, represents a binding site for integrin alpha3beta1 and heparan sulphate proteoglycan.	Heparitin Sulfate	200-216	laminin subunit alpha 1	Rattus norvegicus	45-59
10229666-10	1999	These data suggest that an IKLLI-containing peptide derived from the laminin alpha1 chain may be an active site of laminin and that its cell adhesion may thus interact with both integrin alpha3beta1 and cell- surface heparan sulphate proteoglycan.	Heparitin Sulfate	217-233	laminin subunit alpha 1	Rattus norvegicus	69-83
10224111-1	1999	The interaction of basic fibroblast growth factor (bFGF) with heparan sulfate (HS)/heparin has been shown to strongly enhance the activity of the growth factor although the mechanism of activation is unclear.	Heparitin Sulfate	62-77	fibroblast growth factor 2	Homo sapiens	19-49
10224111-1	1999	The interaction of basic fibroblast growth factor (bFGF) with heparan sulfate (HS)/heparin has been shown to strongly enhance the activity of the growth factor although the mechanism of activation is unclear.	Heparitin Sulfate	62-77	fibroblast growth factor 2	Homo sapiens	51-55
10224111-1	1999	The interaction of basic fibroblast growth factor (bFGF) with heparan sulfate (HS)/heparin has been shown to strongly enhance the activity of the growth factor although the mechanism of activation is unclear.	Heparitin Sulfate	79-81	fibroblast growth factor 2	Homo sapiens	19-49
10224111-1	1999	The interaction of basic fibroblast growth factor (bFGF) with heparan sulfate (HS)/heparin has been shown to strongly enhance the activity of the growth factor although the mechanism of activation is unclear.	Heparitin Sulfate	79-81	fibroblast growth factor 2	Homo sapiens	51-55
10318803-8	1999	These results altogether indicate that EXTL2/EXTR2 encodes the alpha1,4-N-acetylhexosaminyltransferase that transfers GalNAc/GlcNAc to the tetrasaccharide representing the common glycosaminoglycan-protein linkage region and that is most likely the critical enzyme that determines and initiates the heparin/heparan sulfate synthesis, separating it from the chondroitin sulfate/dermatan sulfate synthesis.	Heparitin Sulfate	306-321	exostosin like glycosyltransferase 2	Homo sapiens	39-44
10318803-8	1999	These results altogether indicate that EXTL2/EXTR2 encodes the alpha1,4-N-acetylhexosaminyltransferase that transfers GalNAc/GlcNAc to the tetrasaccharide representing the common glycosaminoglycan-protein linkage region and that is most likely the critical enzyme that determines and initiates the heparin/heparan sulfate synthesis, separating it from the chondroitin sulfate/dermatan sulfate synthesis.	Heparitin Sulfate	306-321	exostosin like glycosyltransferase 2	Homo sapiens	45-50
10101133-8	1999	It is concluded that (i) HB-EGF interacts with the blastocyst cell surface via high-affinity receptors other than ErbB1, (ii) the HB-EGF interaction with high-affinity blastocysts receptors is regulated by heparan sulfate, and (iii) ErbB4 is a candidate for being a high-affinity receptor for HB-EGF on the surface of implantation-competent blastocysts.	Heparitin Sulfate	206-221	heparin-binding EGF-like growth factor	Mus musculus	25-31
10101133-8	1999	It is concluded that (i) HB-EGF interacts with the blastocyst cell surface via high-affinity receptors other than ErbB1, (ii) the HB-EGF interaction with high-affinity blastocysts receptors is regulated by heparan sulfate, and (iii) ErbB4 is a candidate for being a high-affinity receptor for HB-EGF on the surface of implantation-competent blastocysts.	Heparitin Sulfate	206-221	heparin-binding EGF-like growth factor	Mus musculus	130-136
10101133-8	1999	It is concluded that (i) HB-EGF interacts with the blastocyst cell surface via high-affinity receptors other than ErbB1, (ii) the HB-EGF interaction with high-affinity blastocysts receptors is regulated by heparan sulfate, and (iii) ErbB4 is a candidate for being a high-affinity receptor for HB-EGF on the surface of implantation-competent blastocysts.	Heparitin Sulfate	206-221	heparin-binding EGF-like growth factor	Mus musculus	130-136
10328871-3	1999	A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs.	Heparitin Sulfate	28-43	interferon gamma	Homo sapiens	234-243
10222132-1	1999	Thrombospondin-1 (TSP-1) interacts specifically with heparin and fibronectin in vitro and colocalizes with fibronectin and heparan sulfate in the extracellular matrix (ECM).	Heparitin Sulfate	123-138	thrombospondin 1	Homo sapiens	0-16
10222132-1	1999	Thrombospondin-1 (TSP-1) interacts specifically with heparin and fibronectin in vitro and colocalizes with fibronectin and heparan sulfate in the extracellular matrix (ECM).	Heparitin Sulfate	123-138	thrombospondin 1	Homo sapiens	18-23
10222136-2	1999	To examine the function of syndecan-2, one of the most abundant heparan sulfate proteoglycan in fibroblasts, we performed transfection studies in COS-1 and Swiss 3T3 cells.	Heparitin Sulfate	64-79	syndecan 2	Mus musculus	27-37
10208870-0	1999	Heparan sulfate composition of alternatively spliced CD44 fusion proteins.	Heparitin Sulfate	0-15	CD44 molecule (Indian blood group)	Homo sapiens	53-57
10222136-7	1999	Addition of heparin blocked the effect of full-length syndecan-2, suggesting that heparan sulfate chains in the extracellular domain are necessary to induce filopodia.	Heparitin Sulfate	82-97	syndecan 2	Mus musculus	54-64
10390548-0	1999	Inflammatory mediators regulate cathepsin S in macrophages and microglia: A role in attenuating heparan sulfate interactions.	Heparitin Sulfate	96-111	cathepsin S	Homo sapiens	32-43
10209033-5	1999	Binding of labeled MCP-1 and MIP-1alpha could be inhibited by unlabeled homologous but not heterologous chemokine, and was independent of the presence of heparan sulfate, laminin, or collagen in the subendothelial matrix.	Heparitin Sulfate	154-169	C-C motif chemokine ligand 2	Homo sapiens	19-24
10196157-8	1999	The binding has an apparent dissociation constant of 3 x 10(-10) M. The binding of glypican-1 to VEGF165 is mediated by the heparan sulfate chains of glypican-1, because heparinase treatment abolishes this interaction.	Heparitin Sulfate	124-139	glypican 1	Homo sapiens	83-93
10209033-5	1999	Binding of labeled MCP-1 and MIP-1alpha could be inhibited by unlabeled homologous but not heterologous chemokine, and was independent of the presence of heparan sulfate, laminin, or collagen in the subendothelial matrix.	Heparitin Sulfate	154-169	C-C motif chemokine ligand 3	Homo sapiens	29-39
10196157-8	1999	The binding has an apparent dissociation constant of 3 x 10(-10) M. The binding of glypican-1 to VEGF165 is mediated by the heparan sulfate chains of glypican-1, because heparinase treatment abolishes this interaction.	Heparitin Sulfate	124-139	glypican 1	Homo sapiens	150-160
10378481-0	1999	Possible mechanism for lead inhibition of vascular endothelial cell proliferation: a lower response to basic fibroblast growth factor through inhibition of heparan sulfate synthesis.	Heparitin Sulfate	156-171	fibroblast growth factor 2	Bos taurus	103-133
10378481-10	1999	Since the binding of bFGF to its receptor is strongly promoted by heparan sulfate, the present data suggest that lead inhibits vascular endothelial cell proliferation by induction of a lower response to endogenous bFGF through a suppression of heparan sulfate synthesis.	Heparitin Sulfate	66-81	fibroblast growth factor 2	Bos taurus	21-25
10378481-10	1999	Since the binding of bFGF to its receptor is strongly promoted by heparan sulfate, the present data suggest that lead inhibits vascular endothelial cell proliferation by induction of a lower response to endogenous bFGF through a suppression of heparan sulfate synthesis.	Heparitin Sulfate	244-259	fibroblast growth factor 2	Bos taurus	21-25
10101298-8	1999	The binding to L-selectin was mediated by the lectin domain of L-selectin in a Ca2+-dependent manner and required heparan sulfate side chains, but not sialic acid.	Heparitin Sulfate	114-129	selectin L	Homo sapiens	15-25
10196134-1	1999	Heparan sulfate N-deacetylase/N-sulfotransferase (HSNST) catalyzes the first and obligatory step in the biosynthesis of heparan sulfates and heparin.	Heparitin Sulfate	120-136	N-deacetylase and N-sulfotransferase 1	Homo sapiens	0-48
10101298-8	1999	The binding to L-selectin was mediated by the lectin domain of L-selectin in a Ca2+-dependent manner and required heparan sulfate side chains, but not sialic acid.	Heparitin Sulfate	114-129	selectin L	Homo sapiens	63-73
10051433-0	1999	Heparin and heparan sulphate protect basic fibroblast growth factor from non-enzymic glycosylation.	Heparitin Sulfate	12-28	fibroblast growth factor 2	Homo sapiens	37-67
10075664-5	1999	We report that heparan sulfate, dermatan sulfate, and to a lesser extent, chondroitin sulfate A, displaced HARP bound to the extracellular compartment.	Heparitin Sulfate	15-30	pleiotrophin	Mus musculus	107-111
10075664-7	1999	Exogenous heparin, heparan sulfate, and dermatan sulfate potentiated the growth-stimulatory activity of HARP, suggesting that corresponding proteoglycans could be involved in the regulation of the mitogenic activity of HARP.	Heparitin Sulfate	19-34	pleiotrophin	Mus musculus	104-108
10075664-7	1999	Exogenous heparin, heparan sulfate, and dermatan sulfate potentiated the growth-stimulatory activity of HARP, suggesting that corresponding proteoglycans could be involved in the regulation of the mitogenic activity of HARP.	Heparitin Sulfate	19-34	pleiotrophin	Mus musculus	219-223
10051433-3	1999	In addition to intracellular localization, bFGF is also widely distributed in the extracellular matrix, primarily bound to heparan sulphate proteoglycans (HSPGs).	Heparitin Sulfate	123-139	fibroblast growth factor 2	Homo sapiens	43-47
10100868-3	1999	Analysis of the data obtained from surface plasmon resonance afforded a Kd of approximately 21 nM for the interaction of annexin V with end-chain immobilized heparin and a Kd of approximately 49 nM for the interaction with end-chain immobilized heparan sulfate.	Heparitin Sulfate	245-260	annexin A5	Homo sapiens	121-130
10066769-11	1999	At early time points, both TGF-beta1 and serum induced substantial increases in perlecan bearing chondroitin sulfate and/or heparan sulfate chains.	Heparitin Sulfate	124-139	transforming growth factor beta 1	Homo sapiens	27-36
10037743-0	1999	Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met.	Heparitin Sulfate	0-15	CD44 molecule (Indian blood group)	Homo sapiens	25-29
10037743-0	1999	Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met.	Heparitin Sulfate	0-15	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	144-149
10037743-2	1999	Recent studies have shown that CD44 isoforms containing the alternatively spliced exon v3 carry heparan sulfate side chains and are able to bind heparin-binding growth factors.	Heparitin Sulfate	96-111	CD44 molecule (Indian blood group)	Homo sapiens	31-35
10037743-5	1999	We demonstrate that a CD44v3 splice variant efficiently binds HGF/SF via its heparan sulfate side chain.	Heparitin Sulfate	77-92	hepatocyte growth factor	Homo sapiens	62-68
10037743-8	1999	By heparitinase treatment and the use of a mutant HGF/SF with greatly decreased affinity for heparan sulfate, we show that the enhancement of c-Met signal transduction induced by CD44v3 was critically dependent on heparan sulfate moieties.	Heparitin Sulfate	93-108	hepatocyte growth factor	Homo sapiens	50-56
10037743-8	1999	By heparitinase treatment and the use of a mutant HGF/SF with greatly decreased affinity for heparan sulfate, we show that the enhancement of c-Met signal transduction induced by CD44v3 was critically dependent on heparan sulfate moieties.	Heparitin Sulfate	93-108	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	142-147
10037743-8	1999	By heparitinase treatment and the use of a mutant HGF/SF with greatly decreased affinity for heparan sulfate, we show that the enhancement of c-Met signal transduction induced by CD44v3 was critically dependent on heparan sulfate moieties.	Heparitin Sulfate	214-229	hepatocyte growth factor	Homo sapiens	50-56
10037743-8	1999	By heparitinase treatment and the use of a mutant HGF/SF with greatly decreased affinity for heparan sulfate, we show that the enhancement of c-Met signal transduction induced by CD44v3 was critically dependent on heparan sulfate moieties.	Heparitin Sulfate	214-229	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	142-147
10037743-9	1999	Our results identify heparan sulfate-modified CD44 (CD44-HS) as a functional co-receptor for HGF/SF which promotes signaling through the receptor tyrosine kinase c-Met, presumably by concentrating and presenting HGF/SF.	Heparitin Sulfate	21-36	CD44 molecule (Indian blood group)	Homo sapiens	46-50
10037743-9	1999	Our results identify heparan sulfate-modified CD44 (CD44-HS) as a functional co-receptor for HGF/SF which promotes signaling through the receptor tyrosine kinase c-Met, presumably by concentrating and presenting HGF/SF.	Heparitin Sulfate	21-36	CD44 molecule (Indian blood group)	Homo sapiens	52-59
10037743-9	1999	Our results identify heparan sulfate-modified CD44 (CD44-HS) as a functional co-receptor for HGF/SF which promotes signaling through the receptor tyrosine kinase c-Met, presumably by concentrating and presenting HGF/SF.	Heparitin Sulfate	21-36	hepatocyte growth factor	Homo sapiens	93-99
10037743-9	1999	Our results identify heparan sulfate-modified CD44 (CD44-HS) as a functional co-receptor for HGF/SF which promotes signaling through the receptor tyrosine kinase c-Met, presumably by concentrating and presenting HGF/SF.	Heparitin Sulfate	21-36	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	162-167
10037743-9	1999	Our results identify heparan sulfate-modified CD44 (CD44-HS) as a functional co-receptor for HGF/SF which promotes signaling through the receptor tyrosine kinase c-Met, presumably by concentrating and presenting HGF/SF.	Heparitin Sulfate	21-36	hepatocyte growth factor	Homo sapiens	212-218
10224661-2	1999	Deficiency of sulphamidase results in the lysosomal storage of the glycosaminoglycan (GAG) heparan sulphate (HS) and is termed mucopolysaccharidosis type IIIA (MPS IIIA).	Heparitin Sulfate	109-111	N-sulfoglucosamine sulfohydrolase	Homo sapiens	14-26
10914239-1	1999	Danaparoid sodium is an antithrombin composed of 3 glycosaminoglycans: heparan sulfate, dermatan sulfate and chondroitin sulfate.	Heparitin Sulfate	71-86	serpin family C member 1	Homo sapiens	24-36
10224661-3	1999	Sulphamidase catalyses the hydrolysis of an N-linked sulphate from the nonreducing terminal glucosaminide residue of HS (Fig.	Heparitin Sulfate	117-119	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-12
10064733-7	1999	These observations indicate that Abeta and apoE are taken up into cells by a common pathway involving heparan sulfate proteoglycans.	Heparitin Sulfate	102-117	amyloid beta precursor protein	Homo sapiens	33-38
10026234-10	1999	These findings suggest that antithrombin, probably in association with heparin or heparan sulfate, is internalized by renal proximal epithelial cells.	Heparitin Sulfate	82-97	serpin family C member 1	Homo sapiens	28-40
10064733-7	1999	These observations indicate that Abeta and apoE are taken up into cells by a common pathway involving heparan sulfate proteoglycans.	Heparitin Sulfate	102-117	apolipoprotein E	Homo sapiens	43-47
9988774-0	1999	Heparan sulfate mediates bFGF transport through basement membrane by diffusion with rapid reversible binding.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Bos taurus	25-29
10333361-0	1999	Binding of interleukin-8 to heparan sulphate enhances cervical maturation in rabbits.	Heparitin Sulfate	28-44	interleukin-8	Oryctolagus cuniculus	11-24
10333361-11	1999	We conclude that binding to HS enhances the activity of IL-8 in inducing cervical maturation.	Heparitin Sulfate	28-30	interleukin-8	Oryctolagus cuniculus	56-60
10049766-2	1999	However, it has recently been shown that CTAP-III, released from platelets, can act like a heparanase enzyme and degrade heparan sulfate.	Heparitin Sulfate	121-136	pro-platelet basic protein	Homo sapiens	41-49
9988721-0	1999	Apolipoprotein E containing high density lipoprotein stimulates endothelial production of heparan sulfate rich in biologically active heparin-like domains.	Heparitin Sulfate	90-105	apolipoprotein E	Mus musculus	0-16
9988774-2	1999	Heparan sulfate binds bFGF, and this interaction has been demonstrated to protect bFGF against physical denaturation and protease degradation.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Bos taurus	22-26
9988774-2	1999	Heparan sulfate binds bFGF, and this interaction has been demonstrated to protect bFGF against physical denaturation and protease degradation.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Bos taurus	82-86
9988774-3	1999	The high concentrations of heparan sulfate in basement membranes have implicated these matrices as storage sites for bFGF in vivo.	Heparitin Sulfate	27-42	fibroblast growth factor 2	Bos taurus	117-121
9988774-8	1999	In addition, bFGF-heparan sulfate binding was disrupted in diffusion studies with high ionic strength buffer and buffers containing protamine sulfate.	Heparitin Sulfate	18-33	fibroblast growth factor 2	Bos taurus	13-17
9988774-9	1999	Transport of bFGF was enhanced dramatically when heparan sulfate binding was inhibited.	Heparitin Sulfate	49-64	fibroblast growth factor 2	Bos taurus	13-17
9971750-2	1999	We demonstrate that the cell surface heparan sulfate proteoglycan syndecan-2 plays a critical role in spine development.	Heparitin Sulfate	37-52	syndecan 2	Rattus norvegicus	66-76
10050759-4	1999	Here we report that L-selectin-reactive molecules in the kidney are chondroitin sulfate and heparan sulfate proteoglycans of 500-1000 kDa, unlike those in HEV bearing sialyl Lewis X-like carbohydrates.	Heparitin Sulfate	92-107	selectin L	Homo sapiens	20-30
10026256-1	1999	Keratinocyte growth factor (KGF) is an unusual fibroblast growth factor (FGF) family member in that its activity is largely restricted to epithelial cells, and added heparin/heparan sulfate inhibits its activity in most cell types.	Heparitin Sulfate	174-189	fibroblast growth factor 7	Cricetulus griseus	0-26
10026256-1	1999	Keratinocyte growth factor (KGF) is an unusual fibroblast growth factor (FGF) family member in that its activity is largely restricted to epithelial cells, and added heparin/heparan sulfate inhibits its activity in most cell types.	Heparitin Sulfate	174-189	fibroblast growth factor 7	Cricetulus griseus	28-31
9888791-6	1999	3H1, a monoclonal antibody that recognizes an epitope within the lipid-binding C-terminal domain of apoE, decreased binding of apoE to chondroitin sulfate proteoglycans in solid-phase assays by 77% and to heparan sulfate proteoglycans by 46%, suggesting that this region is of increased importance for binding to chondroitin sulfate proteoglycans.	Heparitin Sulfate	205-220	apolipoprotein E	Homo sapiens	127-131
10051750-8	1999	Our results suggest that HB-GAM is important for the neurite outgrowth of thalamic neurons and it may function as an ECM-bound guidance cue for thalamic neurons that possess HB-GAM-binding heparan sulphates on their cell membrane.	Heparitin Sulfate	189-206	pleiotrophin	Rattus norvegicus	25-31
10051750-8	1999	Our results suggest that HB-GAM is important for the neurite outgrowth of thalamic neurons and it may function as an ECM-bound guidance cue for thalamic neurons that possess HB-GAM-binding heparan sulphates on their cell membrane.	Heparitin Sulfate	189-206	pleiotrophin	Rattus norvegicus	174-180
9949192-3	1999	All nine proteins-laminin-1, fibronectin, thrombospondin-1, NCAM, L1, protease nexin-1, urokinase plasminogen activator, thrombin, and fibroblast growth factor-2-bound brain heparan sulfate less strongly than heparin, but the degree of difference in affinity varied considerably.	Heparitin Sulfate	174-189	serpin family E member 2	Rattus norvegicus	70-119
9949192-4	1999	Protease nexin-1 bound brain heparan sulfate only 1.8-fold less tightly than heparin (Kdvalues of 35 vs. 20 nM, respectively), whereas NCAM and L1 bound heparin well (Kd approximately 140 nM) but failed to bind detectably to brain heparan sulfate (Kd&gt;3 microM).	Heparitin Sulfate	29-44	serpin family E member 2	Rattus norvegicus	0-16
9949192-6	1999	Overall, the highest affinities were observed with intact heparan sulfate proteoglycans: laminin-1"s affinities for the proteoglycans cerebroglycan (glypican-2), glypican-1 and syndecan-3 were 300- to 1800-fold stronger than its affinity for brain heparan sulfate.	Heparitin Sulfate	58-73	laminin subunit alpha 1	Rattus norvegicus	89-98
9949192-6	1999	Overall, the highest affinities were observed with intact heparan sulfate proteoglycans: laminin-1"s affinities for the proteoglycans cerebroglycan (glypican-2), glypican-1 and syndecan-3 were 300- to 1800-fold stronger than its affinity for brain heparan sulfate.	Heparitin Sulfate	58-73	glypican 2	Rattus norvegicus	134-147
9949192-6	1999	Overall, the highest affinities were observed with intact heparan sulfate proteoglycans: laminin-1"s affinities for the proteoglycans cerebroglycan (glypican-2), glypican-1 and syndecan-3 were 300- to 1800-fold stronger than its affinity for brain heparan sulfate.	Heparitin Sulfate	58-73	glypican 2	Rattus norvegicus	149-159
9949192-6	1999	Overall, the highest affinities were observed with intact heparan sulfate proteoglycans: laminin-1"s affinities for the proteoglycans cerebroglycan (glypican-2), glypican-1 and syndecan-3 were 300- to 1800-fold stronger than its affinity for brain heparan sulfate.	Heparitin Sulfate	58-73	glypican 1	Rattus norvegicus	162-172
9949192-7	1999	In contrast, the affinities of fibroblast growth factor-2 for cerebroglycan and for brain heparan sulfate were similar.	Heparitin Sulfate	90-105	fibroblast growth factor 2	Rattus norvegicus	31-57
9990141-2	1999	Treatment of immunoprecipitated HSPG with HNO2, heparitinase, and chondroitinase ABC revealed that ACC3 cells synthesized HSPG molecules composed of 470-kDa core protein and heparan sulfate but not of chondroitin sulfate.	Heparitin Sulfate	174-189	CD44 molecule (Indian blood group)	Homo sapiens	122-126
9882449-3	1999	The interaction of heparin and heparan sulfate with C1INH was first examined using surface plasmon resonance.	Heparitin Sulfate	31-46	serpin family G member 1	Homo sapiens	52-57
9888791-6	1999	3H1, a monoclonal antibody that recognizes an epitope within the lipid-binding C-terminal domain of apoE, decreased binding of apoE to chondroitin sulfate proteoglycans in solid-phase assays by 77% and to heparan sulfate proteoglycans by 46%, suggesting that this region is of increased importance for binding to chondroitin sulfate proteoglycans.	Heparitin Sulfate	205-220	apolipoprotein E	Homo sapiens	100-104
14517432-5	1999	TSP displaced 36% of (125)I-VEGF(165) from HDMEC and this was comparable to the 27% reduction in (125)I-VEGF(165) binding to HDMEC upon cleavage of cell surface heparan sulfate (HS).	Heparitin Sulfate	178-180	thrombospondin 1	Homo sapiens	0-3
9890894-10	1999	These results suggest that a complex of Ig module II and heparan sulfate is the base common active core of the FGFR ectodomain and that flanking structural domains modify FGF affinity and determine specificity.	Heparitin Sulfate	57-72	fibroblast growth factor 1	Homo sapiens	111-114
14517433-2	1999	As exon 7-containing isoforms of VEGF bind to heparin, angiogenesis may be modulated by heparin/heparan sulfate.	Heparitin Sulfate	96-111	vascular endothelial growth factor A	Homo sapiens	33-37
9864155-2	1999	We examined the consequence of manipulating soluble heparin and cell-surface heparan sulfate to IL-7-dependent responses of B-cell precursors.	Heparitin Sulfate	77-92	interleukin 7	Mus musculus	96-100
10094189-1	1999	Sanfilippo B syndrome (mucopolysaccharidosis IIIB, MPS IIIB) is caused by a deficiency of alpha-N-acetylglucosaminidase, a lysosomal enzyme involved in the degradation of heparan sulphate.	Heparitin Sulfate	171-187	N-acetyl-alpha-glucosaminidase	Homo sapiens	51-59
10516434-11	1999	Because many growth factors and cytokines interact with cells via heparin/heparan sulfate-proteoglycan, RPL29/HIP may play an important role on the cell surface by modulating interactions between cells and extracellular molecules.	Heparitin Sulfate	74-89	ribosomal protein L29	Homo sapiens	104-113
10094189-1	1999	Sanfilippo B syndrome (mucopolysaccharidosis IIIB, MPS IIIB) is caused by a deficiency of alpha-N-acetylglucosaminidase, a lysosomal enzyme involved in the degradation of heparan sulphate.	Heparitin Sulfate	171-187	N-acetyl-alpha-glucosaminidase	Homo sapiens	90-119
9884409-1	1999	A monoclonal antibody, B1C1, binding to an epitope of antigenic site II of the herpes simplex virus type 1 (HSV-1) glycoprotein gC-1, is a potent inhibitor of two important biological functions of gC-1: its binding to cell surface heparan sulfate and its binding to the receptor for complement factor C3b.	Heparitin Sulfate	231-246	solute carrier family 25 member 22	Homo sapiens	128-132
9872731-2	1999	In this study we have analyzed the expression of CD44v3-containing isoforms [containing heparan sulfate addition sites for growth factor binding] in primary breast tumors, axillary nodal metastases and normal breast tissue.	Heparitin Sulfate	88-103	CD44 molecule (Indian blood group)	Homo sapiens	49-53
9884409-1	1999	A monoclonal antibody, B1C1, binding to an epitope of antigenic site II of the herpes simplex virus type 1 (HSV-1) glycoprotein gC-1, is a potent inhibitor of two important biological functions of gC-1: its binding to cell surface heparan sulfate and its binding to the receptor for complement factor C3b.	Heparitin Sulfate	231-246	solute carrier family 25 member 22	Homo sapiens	197-201
9869645-3	1999	Heparan sulfate proteoglycans (HSPG), which are also abundant in the space of Disse, mediate this enhanced binding.	Heparitin Sulfate	0-15	syndecan 2	Homo sapiens	31-35
9987917-4	1999	The decrease in GUSB activity resulted in storage of GAGs predominantly heparan sulfate and chondroitin sulfate.	Heparitin Sulfate	72-87	glucuronidase beta	Canis lupus familiaris	16-20
10702706-7	1999	Despite normal thrombin times in all samples, the amounts of endogenous heparin/heparan sulfate identified in protease-digested samples by radiometric assay were of sufficient concentrations to produce inordinately prolonged thrombin times when compared with the same concentrations of unfractionated heparin.	Heparitin Sulfate	80-95	coagulation factor II, thrombin	Homo sapiens	225-233
10447264-5	1999	The disease is caused by the inability to degrade dermatan sulphate and heparan sulphate due to mutations in the iduronate-2-sulphatase gene (IDS).	Heparitin Sulfate	72-88	iduronate 2-sulfatase	Homo sapiens	142-145
9931407-3	1998	One recovered GPC4 cDNA with an open reading frame of 1668nt encodes a putative protein containing three heparan sulfate glycosylation signals and the 14 signature cysteines of the glypican family.	Heparitin Sulfate	105-120	glypican 4	Homo sapiens	14-18
10506830-11	1999	Moreover, it implies a novel transcriptional link that creates an FGF action-controlling autoregulatory loop between the heparan sulfate proteoglycans and the heparin-binding FGFs.	Heparitin Sulfate	121-136	fibroblast growth factor 2	Homo sapiens	66-69
10065896-7	1999	It is suggested that antithrombin bound by the specific antithrombin binding sequence of endothelial heparan sulphate, like antithrombin bound to the specific antithrombin binding sequence on heparin surface, inhibits alpha-FXIIa.	Heparitin Sulfate	101-117	serpin family C member 1	Homo sapiens	21-33
10065896-7	1999	It is suggested that antithrombin bound by the specific antithrombin binding sequence of endothelial heparan sulphate, like antithrombin bound to the specific antithrombin binding sequence on heparin surface, inhibits alpha-FXIIa.	Heparitin Sulfate	101-117	serpin family C member 1	Homo sapiens	56-68
10065896-7	1999	It is suggested that antithrombin bound by the specific antithrombin binding sequence of endothelial heparan sulphate, like antithrombin bound to the specific antithrombin binding sequence on heparin surface, inhibits alpha-FXIIa.	Heparitin Sulfate	101-117	serpin family C member 1	Homo sapiens	56-68
10065896-7	1999	It is suggested that antithrombin bound by the specific antithrombin binding sequence of endothelial heparan sulphate, like antithrombin bound to the specific antithrombin binding sequence on heparin surface, inhibits alpha-FXIIa.	Heparitin Sulfate	101-117	serpin family C member 1	Homo sapiens	56-68
9950367-1	1999	Deletions in the heparan sulphate proteoglycan encoding glypican 3 (GPC3) gene have recently been documented in several Simpson-Golabi-Behmel syndrome (SGBS) families.	Heparitin Sulfate	17-33	glypican 3	Homo sapiens	56-66
9950367-1	1999	Deletions in the heparan sulphate proteoglycan encoding glypican 3 (GPC3) gene have recently been documented in several Simpson-Golabi-Behmel syndrome (SGBS) families.	Heparitin Sulfate	17-33	glypican 3	Homo sapiens	68-72
9886295-4	1999	The structure suggests the presence of a binding site for heparan sulfate chains and a mechanism by which the NK1 dimer may engage two receptor molecules through clusters of amino acids located on each protomer and on opposite surfaces of the homodimer.	Heparitin Sulfate	58-73	tachykinin receptor 1	Homo sapiens	110-113
9886295-5	1999	We also report that short (14-mer) heparin fragments effectively dimerize NK1 in solution, implying that heparan sulfate chains may stabilize the NK1 dimer.	Heparitin Sulfate	105-120	tachykinin receptor 1	Homo sapiens	74-77
9886295-5	1999	We also report that short (14-mer) heparin fragments effectively dimerize NK1 in solution, implying that heparan sulfate chains may stabilize the NK1 dimer.	Heparitin Sulfate	105-120	tachykinin receptor 1	Homo sapiens	146-149
9845293-8	1998	Based on their expression patterns, complement factors, apolipoprotein E and heparan sulfate proteoglycans may be produced early in the process of CA formation and may play an important role in the formation of A beta fibrils in CA.	Heparitin Sulfate	77-92	amyloid beta precursor protein	Homo sapiens	211-217
9822691-3	1998	It has been proposed that rodent group IIa PLA2 is anchored to cell surfaces via attachment to heparan sulfate proteoglycan and that this interaction facilitates lipolysis.	Heparitin Sulfate	95-110	phospholipase A2 group IIA	Homo sapiens	43-47
9826351-6	1998	The Pla-expressing strains showed a low-affinity adherence to another basement membrane component, heparan sulfate proteoglycan, but not to chondroitin sulfate proteoglycan.	Heparitin Sulfate	99-114	plasminogen activator protease precursor	Yersinia pestis	4-7
9916505-6	1998	H16 mAb specifically bound to heparin, heparan sulfate and human umbilical vascular endothelial cells (HUVEC).	Heparitin Sulfate	39-54	H1.6 linker histone, cluster member	Homo sapiens	0-3
9916505-9	1998	These results indicate that this mAb could recognize antithrombin III-binding sites on vascular endothelial heparan sulfate, leading to procoagulant states through the inhibition of heparin/heparan sulfate dependent anticoagulant process.	Heparitin Sulfate	108-123	serpin family C member 1	Homo sapiens	53-69
9916505-9	1998	These results indicate that this mAb could recognize antithrombin III-binding sites on vascular endothelial heparan sulfate, leading to procoagulant states through the inhibition of heparin/heparan sulfate dependent anticoagulant process.	Heparitin Sulfate	190-205	serpin family C member 1	Homo sapiens	53-69
9822708-1	1998	Expression of syndecan-1, a cell-surface heparan sulfate proteoglycan, is down-regulated during skeletal muscle differentiation (Larrain, J., Cizmeci-Smith, G., Troncoso, V., Stahl, R. C., Carey, D. J., and Brandan, E. (1997) J. Biol.	Heparitin Sulfate	41-56	syndecan 1	Rattus norvegicus	14-24
9822691-7	1998	In contrast, only those residues on the interfacial binding site of hIIa-PLA2 are involved in binding to membranes; 2) the relative ability of these mutants to hydrolyze cellular phospholipids when enzymes were added exogenously to CHO-K1, NIH-3T3, and RAW 264.7 cells correlates with their relative in vitro affinity for vesicles and not with their affinity for heparin and heparan sulfate.	Heparitin Sulfate	375-390	phospholipase A2 group IIA	Homo sapiens	73-77
9822691-10	1998	Binding of hIIa-PLA2 to cell surface heparan sulfate does not modulate plasma membrane phospholipid hydrolysis by exogenously added hIIa-PLA2.	Heparitin Sulfate	37-52	phospholipase A2 group IIA	Homo sapiens	16-20
9825824-9	1998	Inhibition of cell-bound heparan sulfate proteoglycan sulfation with NaClO3 resulted in an impaired MHC and ICAM-1 expression after IFN-gamma stimulation.	Heparitin Sulfate	25-40	intercellular adhesion molecule 1	Homo sapiens	108-114
9825824-9	1998	Inhibition of cell-bound heparan sulfate proteoglycan sulfation with NaClO3 resulted in an impaired MHC and ICAM-1 expression after IFN-gamma stimulation.	Heparitin Sulfate	25-40	interferon gamma	Homo sapiens	132-141
9825824-10	1998	CONCLUSION: We postulate that IFN-gamma binds to cell-bound heparan sulfate proteoglycan in a sulfation-dependent fashion.	Heparitin Sulfate	60-75	interferon gamma	Homo sapiens	30-39
9792716-0	1998	Multiple heparan sulfate chains are required for optimal syndecan-1 function.	Heparitin Sulfate	9-24	syndecan 1	Homo sapiens	57-67
9792685-4	1998	Both Abeta binding to microglia and Abeta induction of microglial killing of neurons were sensitive to heparitinase cleavage and to competition with heparan sulfate, suggesting membrane-associated heparan sulfate mediated plaque-microglia interactions through the HHQK domain.	Heparitin Sulfate	149-164	amyloid beta precursor protein	Homo sapiens	5-10
9792685-4	1998	Both Abeta binding to microglia and Abeta induction of microglial killing of neurons were sensitive to heparitinase cleavage and to competition with heparan sulfate, suggesting membrane-associated heparan sulfate mediated plaque-microglia interactions through the HHQK domain.	Heparitin Sulfate	149-164	amyloid beta precursor protein	Homo sapiens	36-41
9792685-4	1998	Both Abeta binding to microglia and Abeta induction of microglial killing of neurons were sensitive to heparitinase cleavage and to competition with heparan sulfate, suggesting membrane-associated heparan sulfate mediated plaque-microglia interactions through the HHQK domain.	Heparitin Sulfate	197-212	amyloid beta precursor protein	Homo sapiens	5-10
9792685-4	1998	Both Abeta binding to microglia and Abeta induction of microglial killing of neurons were sensitive to heparitinase cleavage and to competition with heparan sulfate, suggesting membrane-associated heparan sulfate mediated plaque-microglia interactions through the HHQK domain.	Heparitin Sulfate	197-212	amyloid beta precursor protein	Homo sapiens	36-41
9792674-4	1998	We substituted lysine or histidine residues at the C-terminal end of MCP-1 with alanine residues and tested these mutants for their ability to bind heparin, heparan sulfate, hyaluronic acid, and chondroitin sulfate-C.	Heparitin Sulfate	157-172	C-C motif chemokine ligand 2	Homo sapiens	69-74
9792716-7	1998	In regard to cell invasion, cells expressing syndecan-1 bearing a single heparan sulfate attachment site exhibit a hierarchy of function based upon the position of the site within the core protein; the presence of an available attachment site at serine 47 confers the greatest level of activity, while serine 37 contributes little to syndecan-1 function.	Heparitin Sulfate	73-88	syndecan 1	Homo sapiens	45-55
9792716-5	1998	Generally, an increasing loss of syndecan-1 function occurs as the number of heparan sulfate attachment sites decreases.	Heparitin Sulfate	77-92	syndecan 1	Homo sapiens	33-43
9786878-10	1998	The glycosaminoglycans heparin and heparan sulfate bind to IGFBP-5 through its basic carboxyl-terminal domain.	Heparitin Sulfate	35-50	insulin like growth factor binding protein 5	Homo sapiens	59-66
9804327-6	1998	Heparan sulfate proteoglycans and the tetraspanin family of membrane-associated proteins appear to act as cofactors in amphiregulin-driven mitogenesis mediated by the epidermal growth factor receptor, but amphiregulin"s immunolocalization to keratinocyte nuclei and to filopodia may indicate other potentially novel effects.	Heparitin Sulfate	0-15	amphiregulin	Homo sapiens	119-131
9804327-6	1998	Heparan sulfate proteoglycans and the tetraspanin family of membrane-associated proteins appear to act as cofactors in amphiregulin-driven mitogenesis mediated by the epidermal growth factor receptor, but amphiregulin"s immunolocalization to keratinocyte nuclei and to filopodia may indicate other potentially novel effects.	Heparitin Sulfate	0-15	epidermal growth factor receptor	Homo sapiens	167-199
9832037-1	1998	Sanfilippo syndrome type B or mucopolysaccharidosis type IIIB (MPS IIIB) is one of a group of lysosomal storage disorders that are characterised by the inability to breakdown heparan sulphate.	Heparitin Sulfate	175-191	N-acetyl-alpha-glucosaminidase	Homo sapiens	30-61
9832037-1	1998	Sanfilippo syndrome type B or mucopolysaccharidosis type IIIB (MPS IIIB) is one of a group of lysosomal storage disorders that are characterised by the inability to breakdown heparan sulphate.	Heparitin Sulfate	175-191	N-acetyl-alpha-glucosaminidase	Homo sapiens	63-71
9756849-0	1998	The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate.	Heparitin Sulfate	103-118	exostosin glycosyltransferase 1	Homo sapiens	31-35
9765230-6	1998	A specific NCAM-heparan sulfate interaction in this adhesion was further indicated by its inhibition with monoclonal anti-NCAM Fab antibodies that recognize the known heparin-binding domain of NCAM and with the HBD-2 peptide derived from this region, but not with antibodies directed against other regions of the protein including the homophilic binding region.	Heparitin Sulfate	16-31	neural cell adhesion molecule 1	Mus musculus	11-15
9765230-6	1998	A specific NCAM-heparan sulfate interaction in this adhesion was further indicated by its inhibition with monoclonal anti-NCAM Fab antibodies that recognize the known heparin-binding domain of NCAM and with the HBD-2 peptide derived from this region, but not with antibodies directed against other regions of the protein including the homophilic binding region.	Heparitin Sulfate	16-31	neural cell adhesion molecule 1	Mus musculus	122-126
9765230-6	1998	A specific NCAM-heparan sulfate interaction in this adhesion was further indicated by its inhibition with monoclonal anti-NCAM Fab antibodies that recognize the known heparin-binding domain of NCAM and with the HBD-2 peptide derived from this region, but not with antibodies directed against other regions of the protein including the homophilic binding region.	Heparitin Sulfate	16-31	neural cell adhesion molecule 1	Mus musculus	122-126
9788974-5	1998	Moreover, soluble FGF-7 specifically bound immobilized perlecan in a heparan sulfate-independent manner.	Heparitin Sulfate	69-84	fibroblast growth factor 7	Homo sapiens	18-23
9756849-0	1998	The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate.	Heparitin Sulfate	103-118	exostosin glycosyltransferase 2	Homo sapiens	40-44
9737970-1	1998	The enzyme UDP-glucose dehydrogenase (Udpgdh) (EC 1.1.1.22) converts UDP-glucose to UDP-glucuronate, a critical component of the glycosaminoglycans, hyaluronan, chondroitin sulfate, and heparan sulfate.	Heparitin Sulfate	186-201	UDP-glucose 6-dehydrogenase	Homo sapiens	11-36
9719684-8	1998	The structural changes were found to affect the binding of heparan sulfate to the long isoform of platelet-derived growth factor A chain but not to fibroblast growth factor 2.	Heparitin Sulfate	59-74	platelet derived growth factor subunit A	Homo sapiens	98-136
9777710-0	1998	Natural hepatocyte growth factor (HGF) from human serum and a bound form of recombinant HGF with heparan sulfate are indistinguishable in their physicochemical properties.	Heparitin Sulfate	97-112	hepatocyte growth factor	Homo sapiens	34-37
9777710-0	1998	Natural hepatocyte growth factor (HGF) from human serum and a bound form of recombinant HGF with heparan sulfate are indistinguishable in their physicochemical properties.	Heparitin Sulfate	97-112	hepatocyte growth factor	Homo sapiens	88-91
9731758-4	1998	Heparan sulfate compounds on the hOB cell surface were also found to sequester GM-CSF.	Heparitin Sulfate	0-15	colony stimulating factor 2	Homo sapiens	79-85
9742123-5	1998	Recombinant murine FGF-18 protein (rMuFGF-18) stimulated proliferation in the fibroblast cell line NIH 3T3 in vitro in a heparan sulfate-dependent manner.	Heparitin Sulfate	121-136	fibroblast growth factor 18	Mus musculus	19-25
9724101-2	1998	Heparin-binding epidermal growth factor (HBEGF) binds to EGFRs with high affinity and to heparan sulfate proteoglycans, resulting in increased mitogenic potential compared to other EGF family members.	Heparitin Sulfate	89-104	heparin binding EGF like growth factor	Homo sapiens	0-39
9724101-2	1998	Heparin-binding epidermal growth factor (HBEGF) binds to EGFRs with high affinity and to heparan sulfate proteoglycans, resulting in increased mitogenic potential compared to other EGF family members.	Heparitin Sulfate	89-104	heparin binding EGF like growth factor	Homo sapiens	41-46
9737970-1	1998	The enzyme UDP-glucose dehydrogenase (Udpgdh) (EC 1.1.1.22) converts UDP-glucose to UDP-glucuronate, a critical component of the glycosaminoglycans, hyaluronan, chondroitin sulfate, and heparan sulfate.	Heparitin Sulfate	186-201	UDP-glucose 6-dehydrogenase	Homo sapiens	38-44
9722514-1	1998	The interaction of heparan sulfate (HS) with basic fibroblast growth factor (bFGF) is influential in enabling the growth factor to bind to its cell surface tyrosine kinase receptor.	Heparitin Sulfate	19-34	fibroblast growth factor 2	Homo sapiens	45-75
9738008-1	1998	The present study shows that collagen XVIII is, next to perlecan and agrin, the third basal lamina heparan sulfate proteoglycan (HSPG) and the first collagen/proteoglycan with heparan sulfate side chains.	Heparitin Sulfate	99-114	collagen type XVIII alpha 1 chain	Homo sapiens	29-43
9748322-0	1998	Heparan sulfate proteoglycans control intracellular processing of bFGF in vascular smooth muscle cells.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	66-70
9733888-4	1998	In this study, we extended our previous work and demonstrated that soluble A27L protein bound to heparan sulfate on cells and interfered with vaccinia virus infection at a postbinding step.	Heparitin Sulfate	97-112	IMV surface protein	Vaccinia virus	75-79
9733888-5	1998	In addition, we investigated the structure of A27L protein that provides for its binding to heparan sulfate on cells.	Heparitin Sulfate	92-107	IMV surface protein	Vaccinia virus	46-50
9722571-3	1998	In this study, we show that human recombinant CD48 binds to the glycosaminoglycan heparan sulfate on the surface of human epithelial cells.	Heparitin Sulfate	82-97	CD48 molecule	Homo sapiens	46-50
9722514-1	1998	The interaction of heparan sulfate (HS) with basic fibroblast growth factor (bFGF) is influential in enabling the growth factor to bind to its cell surface tyrosine kinase receptor.	Heparitin Sulfate	19-34	fibroblast growth factor 2	Homo sapiens	77-81
9722514-1	1998	The interaction of heparan sulfate (HS) with basic fibroblast growth factor (bFGF) is influential in enabling the growth factor to bind to its cell surface tyrosine kinase receptor.	Heparitin Sulfate	36-38	fibroblast growth factor 2	Homo sapiens	45-75
9722514-1	1998	The interaction of heparan sulfate (HS) with basic fibroblast growth factor (bFGF) is influential in enabling the growth factor to bind to its cell surface tyrosine kinase receptor.	Heparitin Sulfate	36-38	fibroblast growth factor 2	Homo sapiens	77-81
9778119-8	1998	These results raise two possibilities: that exogenous PlGF-1 (in spite of having a low affinity for heparin) was sequestered away from its receptor because of binding to heparan sulphate proteoglycans on the EVT cell surface or the ECM, or that HSPGs could modify the interaction between Flt-1 and PlGF.	Heparitin Sulfate	170-186	placental growth factor	Homo sapiens	54-58
9784842-7	1998	The basic amino acid cluster in this region may be contribute to the binding of HBp17 to heparin or heparan sulfate proteoglycan on the cell surface and extracellular matrix.	Heparitin Sulfate	100-115	fibroblast growth factor binding protein 1	Homo sapiens	80-85
9696812-3	1998	We observed that (i) incubation with rabies virus decreases the surface expression of NCAM; (ii) treatment of susceptible cells with heparan sulfate, a ligand for NCAM, or with NCAM antibodies significantly reduces the rabies virus infection; and (iii) preincubation of rabies virus inoculum with soluble NCAM protein as a receptor decoy drastically neutralizes the capacity of rabies virus to infect susceptible cells.	Heparitin Sulfate	133-148	neural cell adhesion molecule 1	Homo sapiens	86-90
9696812-3	1998	We observed that (i) incubation with rabies virus decreases the surface expression of NCAM; (ii) treatment of susceptible cells with heparan sulfate, a ligand for NCAM, or with NCAM antibodies significantly reduces the rabies virus infection; and (iii) preincubation of rabies virus inoculum with soluble NCAM protein as a receptor decoy drastically neutralizes the capacity of rabies virus to infect susceptible cells.	Heparitin Sulfate	133-148	neural cell adhesion molecule 1	Homo sapiens	163-167
9696812-3	1998	We observed that (i) incubation with rabies virus decreases the surface expression of NCAM; (ii) treatment of susceptible cells with heparan sulfate, a ligand for NCAM, or with NCAM antibodies significantly reduces the rabies virus infection; and (iii) preincubation of rabies virus inoculum with soluble NCAM protein as a receptor decoy drastically neutralizes the capacity of rabies virus to infect susceptible cells.	Heparitin Sulfate	133-148	neural cell adhesion molecule 1	Homo sapiens	163-167
9696812-3	1998	We observed that (i) incubation with rabies virus decreases the surface expression of NCAM; (ii) treatment of susceptible cells with heparan sulfate, a ligand for NCAM, or with NCAM antibodies significantly reduces the rabies virus infection; and (iii) preincubation of rabies virus inoculum with soluble NCAM protein as a receptor decoy drastically neutralizes the capacity of rabies virus to infect susceptible cells.	Heparitin Sulfate	133-148	neural cell adhesion molecule 1	Homo sapiens	163-167
9722571-0	1998	CD48 binds to heparan sulfate on the surface of epithelial cells.	Heparitin Sulfate	14-29	CD48 molecule	Homo sapiens	0-4
9704022-1	1998	Heparan sulphate from endothelial cells (ECHS) has been shown to bind to bFGF with a lower affinity than that seen for 3T3 fibroblast HS (FHS).	Heparitin Sulfate	0-16	fibroblast growth factor 2	Homo sapiens	73-77
9712917-4	1998	In contrast, cells transfected with the glycosylphosphatidylinositol-anchored proteoglycan glypican-1 do not bind to collagen and remain invasive, even though glypican- and syndecan-expressing cells have similar surface levels of heparan sulfate, and their proteoglycans have similar affinities for collagen.	Heparitin Sulfate	230-245	glypican 1	Homo sapiens	91-101
9712917-4	1998	In contrast, cells transfected with the glycosylphosphatidylinositol-anchored proteoglycan glypican-1 do not bind to collagen and remain invasive, even though glypican- and syndecan-expressing cells have similar surface levels of heparan sulfate, and their proteoglycans have similar affinities for collagen.	Heparitin Sulfate	230-245	glypican 1	Homo sapiens	91-99
9705269-5	1998	Although studies on the role of proteoglycans in mediating the binding and mitogenic effects of FGF-2 have previously focused on cell surface heparan sulfate, our results indicate that the core protein of a chondroitin sulfate proteoglycan may also regulate the access of FGF-2 to cell surface signaling receptors in nervous tissue.	Heparitin Sulfate	142-157	fibroblast growth factor 2	Mus musculus	96-101
9742689-6	1998	The present results warn that the formation of the C-2 epimerized compound has to be circumvented in the structural analysis of heparin/heparan sulfate.	Heparitin Sulfate	136-151	complement C2	Homo sapiens	51-54
9725536-3	1998	Scheie syndrome (MPS I S) is due to the deficient activity of alpha-L-iduronidase leading to the intralysosomal accumulation of dermatan sulfate and heparan sulfate.	Heparitin Sulfate	149-164	alpha-L-iduronidase	Homo sapiens	62-81
9688542-0	1998	The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan.	Heparitin Sulfate	117-132	laminin subunit alpha 1	Homo sapiens	38-52
9688542-3	1998	Fragment alpha1VI/V, but not fragment alpha1V, bound to purified alpha1beta1 and alpha2beta1 integrins, to heparin, and to heparan sulfate-substituted domains I and V of perlecan.	Heparitin Sulfate	123-138	collagen type V alpha 1 chain	Homo sapiens	9-16
9621076-1	1998	Herpes simplex virus type 1 (HSV-1) mutants defective for envelope glycoprotein C (gC) and gB are highly impaired in the ability to attach to cell surface heparan sulfate (HS) moieties of proteoglycans, the initial virus receptor.	Heparitin Sulfate	155-170	envelope glycoprotein C	Human alphaherpesvirus 1	58-81
9712518-10	1998	A possible relationship between decreased Wnt5a expression and reduced levels of heparan sulphate proteoglycan is discussed.	Heparitin Sulfate	81-97	wingless-type MMTV integration site family, member 5A	Mus musculus	42-47
9621076-1	1998	Herpes simplex virus type 1 (HSV-1) mutants defective for envelope glycoprotein C (gC) and gB are highly impaired in the ability to attach to cell surface heparan sulfate (HS) moieties of proteoglycans, the initial virus receptor.	Heparitin Sulfate	29-31	envelope glycoprotein C	Human alphaherpesvirus 1	58-81
9637690-2	1998	We have characterized a gene trap mutation in the gene encoding a heparan sulfate biosynthetic enzyme, heparan sulfate 2-sulfotransferase (HS2ST).	Heparitin Sulfate	66-81	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	103-137
9624135-0	1998	Defining the interleukin-8-binding domain of heparan sulfate.	Heparitin Sulfate	45-60	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
9624135-3	1998	By using selectively modified heparin and heparan sulfate fragments in a nitrocellulose filter trapping system, we have analyzed sequence requirements for interleukin-8 binding to heparin/heparan sulfate.	Heparitin Sulfate	188-203	C-X-C motif chemokine ligand 8	Homo sapiens	155-168
9624135-4	1998	We demonstrate that the affinity of a monomeric interleukin-8 molecule for heparin/heparan sulfate is too weak to allow binding at physiological ionic strength, whereas the dimeric form of the protein mediates binding to two sulfated domains of heparan sulfate.	Heparitin Sulfate	83-98	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
9624135-4	1998	We demonstrate that the affinity of a monomeric interleukin-8 molecule for heparin/heparan sulfate is too weak to allow binding at physiological ionic strength, whereas the dimeric form of the protein mediates binding to two sulfated domains of heparan sulfate.	Heparitin Sulfate	245-260	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
9637690-2	1998	We have characterized a gene trap mutation in the gene encoding a heparan sulfate biosynthetic enzyme, heparan sulfate 2-sulfotransferase (HS2ST).	Heparitin Sulfate	66-81	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	139-144
9637690-8	1998	Because 2-O-sulfation has been shown to influence the functional interactions of ligands with heparan sulfate in vitro, we discuss the possibility that the Hs2st mutant phenotype is a consequence of compromised interactions between growth factors and their signal-transducing receptors.	Heparitin Sulfate	94-109	heparan sulfate 2-O-sulfotransferase 1	Mus musculus	156-161
9565561-5	1998	We found that the binding of a bivalent PECAM-1/IgG chimeric protein or multivalent PECAM-1-containing proteoliposomes to multiple different cell lines was 1) strictly dependent upon cell surface expression of PECAM-1 and 2) unaffected by the presence of excess heparin or heparan sulfate.	Heparitin Sulfate	273-288	platelet and endothelial cell adhesion molecule 1	Homo sapiens	40-47
9614116-3	1998	Both native individual alpha1(V) chains and HepV are eluted at identical NaCl concentrations (0.35 M) from a heparin-Sepharose column, and this binding can be inhibited specifically by the addition of free heparin or heparan sulfate.	Heparitin Sulfate	217-232	collagen type V alpha 1 chain	Homo sapiens	23-32
9572470-1	1998	Heparan sulfate is rapidly degraded by an endoglycosidase (heparanase) secreted by activated platelets.	Heparitin Sulfate	0-15	heparanase	Homo sapiens	59-69
9572470-3	1998	Consistent with this hypothesis, platelet heparanase was found to degrade endothelial cell heparan sulfate at pH 6.0 but not at pH 7.4, even though 25% of maximum activity was detected at pH 7.4.	Heparitin Sulfate	91-106	heparanase	Homo sapiens	42-52
9572470-5	1998	Inactivation of heparanase at pH 7.4 did not affect heparin binding and was reversed by 0.5 M NaCl or by heparan sulfate but not by chondroitin sulfate, suggesting inactive heparanase could be tethered on cell surfaces and the function regulated by heparan sulfate.	Heparitin Sulfate	105-120	heparanase	Homo sapiens	16-26
9572470-5	1998	Inactivation of heparanase at pH 7.4 did not affect heparin binding and was reversed by 0.5 M NaCl or by heparan sulfate but not by chondroitin sulfate, suggesting inactive heparanase could be tethered on cell surfaces and the function regulated by heparan sulfate.	Heparitin Sulfate	249-264	heparanase	Homo sapiens	16-26
9572470-7	1998	These findings are consistent with a model in which platelet heparanase is active at the low pH of inflammation but inactive under physiologic conditions preventing inadvertent cleavage of heparan sulfate and loss of physiologic functions of endothelial cells.	Heparitin Sulfate	189-204	heparanase	Homo sapiens	61-71
9694594-1	1998	Collagen XIV is known to bind to the dermatan sulfate chain of decorin and to the heparan sulfate chain of perlecan.	Heparitin Sulfate	82-97	collagen type XIV alpha 1 chain	Gallus gallus	0-12
9623978-4	1998	The ectodomain potently inhibits heparin-mediated FGF-2 mitogenicity because of the poorly sulfated domains in its heparin sulfate chains.	Heparitin Sulfate	115-130	fibroblast growth factor 2	Homo sapiens	50-55
9623978-5	1998	Degradation of these regions by platelet heparanase produces heparin-like heparin sulfate fragments that markedly activate FGF-2 mitogenicity and are found in wound fluids.	Heparitin Sulfate	74-89	fibroblast growth factor 2	Homo sapiens	123-128
9634701-3	1998	The binding of VEGF to its two known receptors, KDR and Flt-1, is modulated by cell-surface-associated heparin-like glycosaminoglycans and exogenous heparin or heparan sulfate.	Heparitin Sulfate	160-175	vascular endothelial growth factor A	Homo sapiens	15-19
9634701-3	1998	The binding of VEGF to its two known receptors, KDR and Flt-1, is modulated by cell-surface-associated heparin-like glycosaminoglycans and exogenous heparin or heparan sulfate.	Heparitin Sulfate	160-175	kinase insert domain receptor	Homo sapiens	48-51
9634701-3	1998	The binding of VEGF to its two known receptors, KDR and Flt-1, is modulated by cell-surface-associated heparin-like glycosaminoglycans and exogenous heparin or heparan sulfate.	Heparitin Sulfate	160-175	fms related receptor tyrosine kinase 1	Homo sapiens	56-61
9565561-5	1998	We found that the binding of a bivalent PECAM-1/IgG chimeric protein or multivalent PECAM-1-containing proteoliposomes to multiple different cell lines was 1) strictly dependent upon cell surface expression of PECAM-1 and 2) unaffected by the presence of excess heparin or heparan sulfate.	Heparitin Sulfate	273-288	platelet and endothelial cell adhesion molecule 1	Homo sapiens	84-91
10420065-4	1998	These lipoproteins may play a role in the removal of excess cholesterol from the brain through interaction with ApoE and heparan sulphate proteoglycans (HSPG) in the subendothelial space of cerebral microvessels.	Heparitin Sulfate	121-137	syndecan 2	Homo sapiens	153-157
9558385-7	1998	To gain insight into the mechanism of inhibition, we have analyzed the interaction of PF-4 with FGF-2/FGFR by using mutant heparan sulfate-deficient Chinese hamster ovary (CHO) cells transfected with the FGFR-1 cDNA (CHOm-FGFR-1) and by examining the direct interaction with FGF-2.	Heparitin Sulfate	123-138	platelet factor 4	Mus musculus	86-90
9645599-3	1998	Heparan sulphate was previously shown to enhance neutrophil chemotactic responses to IL-8.	Heparitin Sulfate	0-16	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
9645599-4	1998	OBJECTIVE: The purpose of this study was to investigate the effect of heparin, heparan sulphate and alpha2-macroglobulin on IL-8 binding to neutrophils and subsequent functional effects in vitro.	Heparitin Sulfate	79-95	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
9597549-1	1998	We have previously provided compelling evidence that human recombinant interleukin 2 (IL-2) binds to the sulfated polysaccharides heparin, highly sulfated heparan sulfate and fucoidan.	Heparitin Sulfate	155-170	interleukin 2	Homo sapiens	71-84
9556569-0	1998	The heparan sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma receptor complex formation.	Heparitin Sulfate	4-19	interferon gamma	Homo sapiens	86-102
9597549-1	1998	We have previously provided compelling evidence that human recombinant interleukin 2 (IL-2) binds to the sulfated polysaccharides heparin, highly sulfated heparan sulfate and fucoidan.	Heparitin Sulfate	155-170	interleukin 2	Homo sapiens	86-90
9597549-11	1998	Overall our data suggest that the binding of human IL-2 to heparin and heparan sulfate does not interfere with IL-2/IL-2 receptor interactions.	Heparitin Sulfate	71-86	interleukin 2	Homo sapiens	51-55
9556569-0	1998	The heparan sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma receptor complex formation.	Heparitin Sulfate	4-19	interferon gamma	Homo sapiens	40-56
9556569-1	1998	Interferon-gamma (IFNgamma), in common with a number of growth factors, binds both to heparan sulfate or heparin-related molecules and to a specific high affinity receptor (IFNgammaR).	Heparitin Sulfate	86-101	interferon gamma	Homo sapiens	0-16
9556569-0	1998	The heparan sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma receptor complex formation.	Heparitin Sulfate	4-19	interferon gamma	Homo sapiens	86-102
9556569-1	1998	Interferon-gamma (IFNgamma), in common with a number of growth factors, binds both to heparan sulfate or heparin-related molecules and to a specific high affinity receptor (IFNgammaR).	Heparitin Sulfate	86-101	interferon gamma	Homo sapiens	18-26
9556569-12	1998	The mechanisms by which heparan sulfate regulates IFNgamma activity may thus include both control of selective protease cleavage events, which directly affect the cytokine activity, and also an ability to modulate the interaction of IFNgamma with the IFNgammaR via competitive binding to the C1 domain.	Heparitin Sulfate	24-39	interferon gamma	Homo sapiens	50-58
9556569-12	1998	The mechanisms by which heparan sulfate regulates IFNgamma activity may thus include both control of selective protease cleavage events, which directly affect the cytokine activity, and also an ability to modulate the interaction of IFNgamma with the IFNgammaR via competitive binding to the C1 domain.	Heparitin Sulfate	24-39	interferon gamma	Homo sapiens	233-241
9535803-3	1998	Because CD44 variants expressing V3 have been shown to carry heparan sulfate side chains and to interact through these side chains with heparan sulfate binding growth factors, we investigated the expression of CD44 variants on endothelium.	Heparitin Sulfate	61-76	CD44 molecule (Indian blood group)	Homo sapiens	8-12
9558337-1	1998	Hepatocyte growth factor/scatter factor (HGF/SF) is a heparan sulfate (HS)-binding growth factor and morphogen for mammary epithelial cells that is produced by mammary stromal fibroblasts.	Heparitin Sulfate	54-69	hepatocyte growth factor	Homo sapiens	41-47
9558337-1	1998	Hepatocyte growth factor/scatter factor (HGF/SF) is a heparan sulfate (HS)-binding growth factor and morphogen for mammary epithelial cells that is produced by mammary stromal fibroblasts.	Heparitin Sulfate	71-73	hepatocyte growth factor	Homo sapiens	41-47
9535803-3	1998	Because CD44 variants expressing V3 have been shown to carry heparan sulfate side chains and to interact through these side chains with heparan sulfate binding growth factors, we investigated the expression of CD44 variants on endothelium.	Heparitin Sulfate	136-151	CD44 molecule (Indian blood group)	Homo sapiens	8-12
9516434-9	1998	The binding of the HS to bFGF or FS-288 was markedly inhibited by heparin (HP) and various HS preparations, but not by chondroitin sulfate, supporting the binding specificity of HS.	Heparitin Sulfate	19-21	fibroblast growth factor 2 L homeolog	Xenopus laevis	25-29
9535912-2	1998	Heparan-sulfate 6-sulfotransferase (HS6ST) catalyzes the transfer of sulfate from 3"-phosphoadenosine 5"-phosphosulfate to position 6 of the N-sulfoglucosamine residue of heparan sulfate.	Heparitin Sulfate	171-186	heparan-sulfate 6-O-sulfotransferase 1	Cricetulus griseus	0-34
9535912-2	1998	Heparan-sulfate 6-sulfotransferase (HS6ST) catalyzes the transfer of sulfate from 3"-phosphoadenosine 5"-phosphosulfate to position 6 of the N-sulfoglucosamine residue of heparan sulfate.	Heparitin Sulfate	171-186	heparan-sulfate 6-O-sulfotransferase 1	Cricetulus griseus	36-41
9546743-7	1998	In vitro binding studies of 125I-perlecan to a 17-amino acid synthetic peptide sequence of HIP, which has a high affinity and specificity for heparin/heparan sulfate, indicates that perlecan binds to the HIP peptide with high affinity (KDapp = 0.6 nM) and in a heparin-inhibitable manner.	Heparitin Sulfate	150-165	ribosomal protein L29	Homo sapiens	91-94
9546743-7	1998	In vitro binding studies of 125I-perlecan to a 17-amino acid synthetic peptide sequence of HIP, which has a high affinity and specificity for heparin/heparan sulfate, indicates that perlecan binds to the HIP peptide with high affinity (KDapp = 0.6 nM) and in a heparin-inhibitable manner.	Heparitin Sulfate	150-165	ribosomal protein L29	Homo sapiens	204-207
9568695-6	1998	Using thioflavin T fluorometry, Congo red staining, and electron microscopy methodology, intact perlecan was found to enhance amylin fibril formation in a dosage-dependent manner, with the majority of these effects attributed to the heparan sulfate GAG chains of perlecan.	Heparitin Sulfate	233-248	heparan sulfate proteoglycan 2	Rattus norvegicus	96-104
9568695-7	1998	Other sulfated GAGs and related macromolecules were also effective in the enhancement of amylin fibril formation in the order of heparin &gt; heparan sulfate &gt; chondroitin-4-sulfate = dermatan sulfate = dextran sulfate &gt; pentosan polysulfate, implicating the importance of the specific GAG/carbohydrate backbone.	Heparitin Sulfate	142-157	islet amyloid polypeptide	Homo sapiens	89-95
9568695-8	1998	The sulfate content of heparin/heparan sulfate was also important for the enhancement of amylin fibril formation in the order of heparin &gt; N-desulfated N-acetylated heparin &gt; completely desulfated N-sulfated heparin &gt; completely desulfated N-acetylated heparin.	Heparitin Sulfate	31-46	islet amyloid polypeptide	Homo sapiens	89-95
9516424-0	1998	Interaction of heparan sulfate from mammary cells with acidic fibroblast growth factor (FGF) and basic FGF.	Heparitin Sulfate	15-30	fibroblast growth factor 1	Homo sapiens	55-86
9516424-0	1998	Interaction of heparan sulfate from mammary cells with acidic fibroblast growth factor (FGF) and basic FGF.	Heparitin Sulfate	15-30	fibroblast growth factor 2	Homo sapiens	97-106
9516424-1	1998	Regulation of the activity of basic FGF by high and low affinity binding sites in heparan sulfate.	Heparitin Sulfate	82-97	fibroblast growth factor 2	Homo sapiens	30-39
9531576-3	1998	We show that syndecan-1 (CD 138), a heparan sulfate proteoglycan, expressed on and actively shed from the surface of most myeloma cells, induces apoptosis and inhibits the growth of myeloma tumor cells and also mediates decreased osteoclast and increased osteoblast differentiation.	Heparitin Sulfate	36-51	syndecan 1	Homo sapiens	13-23
9531576-3	1998	We show that syndecan-1 (CD 138), a heparan sulfate proteoglycan, expressed on and actively shed from the surface of most myeloma cells, induces apoptosis and inhibits the growth of myeloma tumor cells and also mediates decreased osteoclast and increased osteoblast differentiation.	Heparitin Sulfate	36-51	syndecan 1	Homo sapiens	25-31
9531576-6	1998	In contrast to the effect on myeloma cells, the effect of syndecan-1 on osteoclastogenesis only requires the syndecan-1 heparan sulfate chains and not the intact ectodomain, suggesting that syndecan"s effect on myeloma and bone cells occurs through different mechanisms.	Heparitin Sulfate	120-135	syndecan 1	Homo sapiens	58-68
9555948-13	1998	Our results show that remnant binding to liver cells depends on the LDL receptor, on the expression of HSPG core proteins, and on the functionality of heparan sulfate in HSPG.	Heparitin Sulfate	151-166	syndecan 2	Homo sapiens	170-174
9516424-2	1998	We have determined the relationship between the binding sites for acidic fibroblast growth factor (aFGF) and basic FGF (bFGF) in heparan sulfate (HS) prepared from a panel of mammary cell lines and the ability of the HS to activate aFGF and bFGF in DNA synthesis assays.	Heparitin Sulfate	129-144	fibroblast growth factor 1	Homo sapiens	66-97
9516424-2	1998	We have determined the relationship between the binding sites for acidic fibroblast growth factor (aFGF) and basic FGF (bFGF) in heparan sulfate (HS) prepared from a panel of mammary cell lines and the ability of the HS to activate aFGF and bFGF in DNA synthesis assays.	Heparitin Sulfate	129-144	fibroblast growth factor 1	Homo sapiens	99-103
9516434-9	1998	The binding of the HS to bFGF or FS-288 was markedly inhibited by heparin (HP) and various HS preparations, but not by chondroitin sulfate, supporting the binding specificity of HS.	Heparitin Sulfate	91-93	fibroblast growth factor 2 L homeolog	Xenopus laevis	25-29
9516424-2	1998	We have determined the relationship between the binding sites for acidic fibroblast growth factor (aFGF) and basic FGF (bFGF) in heparan sulfate (HS) prepared from a panel of mammary cell lines and the ability of the HS to activate aFGF and bFGF in DNA synthesis assays.	Heparitin Sulfate	129-144	fibroblast growth factor 2	Homo sapiens	109-118
9516424-2	1998	We have determined the relationship between the binding sites for acidic fibroblast growth factor (aFGF) and basic FGF (bFGF) in heparan sulfate (HS) prepared from a panel of mammary cell lines and the ability of the HS to activate aFGF and bFGF in DNA synthesis assays.	Heparitin Sulfate	129-144	fibroblast growth factor 2	Homo sapiens	120-124
9516424-2	1998	We have determined the relationship between the binding sites for acidic fibroblast growth factor (aFGF) and basic FGF (bFGF) in heparan sulfate (HS) prepared from a panel of mammary cell lines and the ability of the HS to activate aFGF and bFGF in DNA synthesis assays.	Heparitin Sulfate	146-148	fibroblast growth factor 1	Homo sapiens	66-97
9516424-2	1998	We have determined the relationship between the binding sites for acidic fibroblast growth factor (aFGF) and basic FGF (bFGF) in heparan sulfate (HS) prepared from a panel of mammary cell lines and the ability of the HS to activate aFGF and bFGF in DNA synthesis assays.	Heparitin Sulfate	146-148	fibroblast growth factor 1	Homo sapiens	99-103
9516424-2	1998	We have determined the relationship between the binding sites for acidic fibroblast growth factor (aFGF) and basic FGF (bFGF) in heparan sulfate (HS) prepared from a panel of mammary cell lines and the ability of the HS to activate aFGF and bFGF in DNA synthesis assays.	Heparitin Sulfate	146-148	fibroblast growth factor 2	Homo sapiens	109-118
9545645-1	1998	SPOCK, previously identified as testican, is a modular proteoglycan that carries both chondroitin and heparan sulfate glycosaminoglycan side chains.	Heparitin Sulfate	102-117	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1	Homo sapiens	0-5
9516424-2	1998	We have determined the relationship between the binding sites for acidic fibroblast growth factor (aFGF) and basic FGF (bFGF) in heparan sulfate (HS) prepared from a panel of mammary cell lines and the ability of the HS to activate aFGF and bFGF in DNA synthesis assays.	Heparitin Sulfate	146-148	fibroblast growth factor 2	Homo sapiens	120-124
9516434-8	1998	Specific binding of the HS to bFGF and FS-288, the COOH-terminal truncated form, was observed in the filter binding assay, whereas HS did not bind to FS-315, indicating that the acidic Glu-rich domain of FS-315 precluded the binding.	Heparitin Sulfate	24-26	fibroblast growth factor 2 L homeolog	Xenopus laevis	30-34
9548595-3	1998	In solid phase assays, xCAL 3-6a inhibited the binding of LPL to both heparan sulfate and heparin.	Heparitin Sulfate	70-85	lipoprotein lipase	Bos taurus	58-61
9488672-7	1998	The affinity of HPRG for various GAGs measured in a competition assay decreased in the following order: heparin &gt; dermatan sulfate &gt; heparan sulfate &gt; chondroitin sulfate A.	Heparitin Sulfate	139-154	histidine rich glycoprotein	Homo sapiens	16-20
9495345-6	1998	This association appears to have a functional significance, because heparan sulphate facilitates RANTES inhibition of HIV-1 infection of monocytes.	Heparitin Sulfate	68-84	C-C motif chemokine ligand 5	Homo sapiens	97-103
9500522-0	1998	Interleukin-5 binds to heparin/heparan sulfate.	Heparitin Sulfate	31-46	interleukin 5	Homo sapiens	0-13
9500522-5	1998	We show that at low IL-5 concentrations heparan sulfate enhances the proliferation of an IL-5-dependent cell line.	Heparitin Sulfate	40-55	interleukin 5	Homo sapiens	20-24
9500522-5	1998	We show that at low IL-5 concentrations heparan sulfate enhances the proliferation of an IL-5-dependent cell line.	Heparitin Sulfate	40-55	interleukin 5	Homo sapiens	89-93
9500522-11	1998	These data suggest that the binding of IL-5 to heparan sulfate modulates IL-5 activity.	Heparitin Sulfate	47-62	interleukin 5	Homo sapiens	39-43
9500522-11	1998	These data suggest that the binding of IL-5 to heparan sulfate modulates IL-5 activity.	Heparitin Sulfate	47-62	interleukin 5	Homo sapiens	73-77
9468523-2	1998	Because interferon-gamma (IFN-gamma), a cytokine with known antiproliferative and antitumoral activity, binds with high affinity to the heparan sulfate side chains of perlecan, we investigated the activity of IFN-gamma on perlecan gene expression and cell growth in colon carcinoma cells.	Heparitin Sulfate	136-151	interferon gamma	Homo sapiens	8-24
9468523-2	1998	Because interferon-gamma (IFN-gamma), a cytokine with known antiproliferative and antitumoral activity, binds with high affinity to the heparan sulfate side chains of perlecan, we investigated the activity of IFN-gamma on perlecan gene expression and cell growth in colon carcinoma cells.	Heparitin Sulfate	136-151	interferon gamma	Homo sapiens	26-35
9445060-0	1998	A27L protein mediates vaccinia virus interaction with cell surface heparan sulfate.	Heparitin Sulfate	67-82	IMV surface protein	Vaccinia virus	0-4
9466983-3	1998	L-selectin also recognizes endothelial proteoglycans in a calcium-dependent manner, via heparan sulfate (HS) glycosaminoglycan chains enriched in unsubstituted glucosamine units.	Heparitin Sulfate	88-103	selectin L	Homo sapiens	0-10
9466983-3	1998	L-selectin also recognizes endothelial proteoglycans in a calcium-dependent manner, via heparan sulfate (HS) glycosaminoglycan chains enriched in unsubstituted glucosamine units.	Heparitin Sulfate	105-107	selectin L	Homo sapiens	0-10
9466983-4	1998	We now show that these HS chains can also bind P-selectin, but not E-selectin.	Heparitin Sulfate	23-25	selectin P	Homo sapiens	47-57
9466983-9	1998	L-selectin binding fragments include more heavily sulfated and epimerized regions and, as with the endothelial HS chains, they are enriched in free amino groups.	Heparitin Sulfate	111-113	selectin L	Homo sapiens	0-10
9600207-4	1998	Both forms of caprine MPS IIID result from a nonsense mutation and consequent deficiency of lysosomal N-acetylglucosamine 6-sulfatase (G6S) activity and are associated with tissue storage and urinary excretion of heparan sulfate (HS).	Heparitin Sulfate	213-228	glucosamine (N-acetyl)-6-sulfatase	Homo sapiens	135-138
9600207-4	1998	Both forms of caprine MPS IIID result from a nonsense mutation and consequent deficiency of lysosomal N-acetylglucosamine 6-sulfatase (G6S) activity and are associated with tissue storage and urinary excretion of heparan sulfate (HS).	Heparitin Sulfate	230-232	glucosamine (N-acetyl)-6-sulfatase	Homo sapiens	135-138
9445060-14	1998	All the data together indicated that A27L protein could be an attachment protein that mediates vaccinia virus binding to cell surface heparan sulfate during viral infection.	Heparitin Sulfate	134-149	IMV surface protein	Vaccinia virus	37-41
9443108-8	1998	Binding of gp160 to Fn-CTHBD is a saturable and specific process that is blocked by antibodies to Fn-CTHBD and by heparin and is inhibited to a minor extent by heparan sulfate and dextran sulfate.	Heparitin Sulfate	160-175	glutamyl aminopeptidase	Homo sapiens	11-16
9442018-6	1998	The latter has not been reported to date for heparin/heparan sulfate, indicating the substrate specificity of the D-glucuronyl C-5 epimerase.	Heparitin Sulfate	53-68	glucuronic acid epimerase	Homo sapiens	114-140
9443878-0	1998	NAGLU mutations underlying Sanfilippo syndrome type B. Sanfilippo syndrome type B (mucopolysaccharidosis III B) is a rare autosomal recessive disease caused by deficiency of alpha-N-acetylglucosaminidase, one of the enzymes required for the lysosomal degradation of heparan sulfate.	Heparitin Sulfate	266-281	N-acetyl-alpha-glucosaminidase	Homo sapiens	0-5
9443878-0	1998	NAGLU mutations underlying Sanfilippo syndrome type B. Sanfilippo syndrome type B (mucopolysaccharidosis III B) is a rare autosomal recessive disease caused by deficiency of alpha-N-acetylglucosaminidase, one of the enzymes required for the lysosomal degradation of heparan sulfate.	Heparitin Sulfate	266-281	N-acetyl-alpha-glucosaminidase	Homo sapiens	174-203
9405287-2	1998	The disorder is caused by a deficiency of the lysosomal enzyme sulphamidase which is a requisite for the degradation of heparan sulphate.	Heparitin Sulfate	120-136	N-sulfoglucosamine sulfohydrolase	Homo sapiens	63-75
9428228-1	1998	BACKGROUND &amp; AIMS: Hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, binds to heparan sulfate.	Heparitin Sulfate	98-113	hepatocyte growth factor	Canis lupus familiaris	23-47
9428228-1	1998	BACKGROUND &amp; AIMS: Hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, binds to heparan sulfate.	Heparitin Sulfate	98-113	hepatocyte growth factor	Canis lupus familiaris	49-52
9417075-1	1998	We have demonstrated by affinity chromatography that hepatocyte growth factor/scatter factor (HGF/SF) binds strongly to dermatan sulfate (DS), with a similar ionic strength dependence to that previously seen with heparan sulfate (HS).	Heparitin Sulfate	213-228	hepatocyte growth factor	Homo sapiens	94-100
9417075-1	1998	We have demonstrated by affinity chromatography that hepatocyte growth factor/scatter factor (HGF/SF) binds strongly to dermatan sulfate (DS), with a similar ionic strength dependence to that previously seen with heparan sulfate (HS).	Heparitin Sulfate	230-232	hepatocyte growth factor	Homo sapiens	94-100
9473690-3	1998	In a previous study, we showed that basic fibroblast growth factor (bFGF), another heparin-binding protein is increased in Alzheimer"s disease (AD), and appears to be associated with the heparan-sulfate proteoglycans bound to B/A4 amyloid (Biochem.	Heparitin Sulfate	187-202	fibroblast growth factor 2	Homo sapiens	36-66
9473690-3	1998	In a previous study, we showed that basic fibroblast growth factor (bFGF), another heparin-binding protein is increased in Alzheimer"s disease (AD), and appears to be associated with the heparan-sulfate proteoglycans bound to B/A4 amyloid (Biochem.	Heparitin Sulfate	187-202	fibroblast growth factor 2	Homo sapiens	68-72
9473690-3	1998	In a previous study, we showed that basic fibroblast growth factor (bFGF), another heparin-binding protein is increased in Alzheimer"s disease (AD), and appears to be associated with the heparan-sulfate proteoglycans bound to B/A4 amyloid (Biochem.	Heparitin Sulfate	187-202	azurocidin 1	Homo sapiens	83-106
9443108-8	1998	Binding of gp160 to Fn-CTHBD is a saturable and specific process that is blocked by antibodies to Fn-CTHBD and by heparin and is inhibited to a minor extent by heparan sulfate and dextran sulfate.	Heparitin Sulfate	160-175	fibronectin 1	Homo sapiens	20-28
9484897-13	1998	The interaction between LcrG and heparan sulphate anchored at the surface of HeLa cells could be a signal triggering deployment of the Yop translocation machinery.	Heparitin Sulfate	33-49	control of Yop release	Yersinia enterocolitica	24-28
9417813-0	1997	Characterization of human recombinant interleukin 2 binding to heparin and heparan sulfate using an ELISA approach.	Heparitin Sulfate	75-90	interleukin 2	Homo sapiens	38-51
9814672-5	1998	Heparan sulphate appears to be one of the anionic EC membrane structures with which cationic beta2GPI interacts, as supported by studies with heparitinase-treated EC.	Heparitin Sulfate	0-16	apolipoprotein H	Homo sapiens	93-101
9417813-9	1997	Of six heparan sulfates tested, only one highly sulfated preparation competed for IL-2.	Heparitin Sulfate	7-23	interleukin 2	Homo sapiens	82-86
9362504-1	1997	We have investigated the expression patterns and subcellular localization in nervous tissue of glypican, a major glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan that is predominantly synthesized by neurons, and of biglycan, a small, leucine-rich chondroitin sulfate proteoglycan.	Heparitin Sulfate	151-166	glypican 1	Homo sapiens	95-103
9458270-3	1997	Control experiments with heparinase indicate that at least 90% of the LPL activity is derived from LPL bound to heparan sulfate chains.	Heparitin Sulfate	112-127	lipoprotein lipase	Homo sapiens	70-73
9458270-3	1997	Control experiments with heparinase indicate that at least 90% of the LPL activity is derived from LPL bound to heparan sulfate chains.	Heparitin Sulfate	112-127	lipoprotein lipase	Homo sapiens	99-102
9375678-1	1997	Perlecan is a specific heparan sulfate proteoglycan that accumulates in the fibrillar beta-amyloid (A beta) deposits of Alzheimer"s disease.	Heparitin Sulfate	23-38	amyloid beta precursor protein	Homo sapiens	100-106
9464851-8	1997	While native EC-SOD shows high affinity for heparin and heparan sulphate, 90% of the EC-SOD in seminal plasma lacks the high affinity at ejaculation.	Heparitin Sulfate	56-72	superoxide dismutase 3	Homo sapiens	13-19
9362504-5	1997	Nuclear localization of glypican beta-galactosidase or Fc fusion proteins in transfected 293 cells and C6 glioma cells was greatly reduced or abolished after mutation of the basic amino acids or deletion of the sequence containing the nuclear localization signal, and no nuclear staining was seen in the case of heparan sulfate and chondroitin sulfate proteoglycans that do not possess a nuclear localization signal, such as syndecan-3 or decorin (which is closely related in structure to biglycan).	Heparitin Sulfate	312-327	glypican 1	Homo sapiens	24-32
9581574-2	1997	We have analysed in resting human neutrophils the subcellular localization of heparanase, a heparan-sulphate-degrading endoglycosidase that can degrade basement-membrane components, thereby facilitating neutrophil passage into the tissue during an inflammatory reaction.	Heparitin Sulfate	92-108	heparanase	Homo sapiens	78-88
9403071-1	1997	The human ribosomal protein L29, which we reported previously, was subsequently shown to have the same nucleotide sequence as that of cell surface heparin/heparan sulfate-binding protein, designated HP/HS interacting protein.	Heparitin Sulfate	155-170	ribosomal protein L29	Homo sapiens	10-31
9395268-3	1997	Addition of LNA to porcine aortic endothelial cells reduced 125I-labeled antithrombin III binding to the cell surface heparan sulfate in a dose- and time-dependent fashion.	Heparitin Sulfate	118-133	serpin family C member 1	Homo sapiens	73-89
9371517-9	1997	All cell lines tested displayed the ability to bind to a heparan sulfate (HS)-binding synthetic peptide motif of HIP in a HP-inhibitable fashion.	Heparitin Sulfate	57-72	ribosomal protein L29	Homo sapiens	113-116
9371517-9	1997	All cell lines tested displayed the ability to bind to a heparan sulfate (HS)-binding synthetic peptide motif of HIP in a HP-inhibitable fashion.	Heparitin Sulfate	74-76	ribosomal protein L29	Homo sapiens	113-116
9499937-4	1997	The interaction of PF4 with heparan sulfates at the surface of the EC appeared to be implicated in the inhibition mechanism of MMP-1 but not in that of MMP-3.	Heparitin Sulfate	28-44	platelet factor 4	Homo sapiens	19-22
9499937-4	1997	The interaction of PF4 with heparan sulfates at the surface of the EC appeared to be implicated in the inhibition mechanism of MMP-1 but not in that of MMP-3.	Heparitin Sulfate	28-44	matrix metallopeptidase 1	Homo sapiens	127-132
9351452-3	1997	In the present study, we have investigated the regulation of expression of two key heparan sulfate chain-carrying core proteins, syndecan-1 and syndecan-4, in a mouse/rat infarct model of tissue injury and repair.	Heparitin Sulfate	83-98	syndecan 1	Mus musculus	129-139
9466688-0	1997	Heparan sulfate is required for interaction and activation of the epithelial cell fibroblast growth factor receptor-2IIIb with stromal-derived fibroblast growth factor-7.	Heparitin Sulfate	0-15	fibroblast growth factor 7	Homo sapiens	143-169
9466688-2	1997	Different effects of the manipulation of cellular heparan sulfates and heparin on activities of FGF-7 relative to FGF-1 in epithelial cells suggest that pericellular heparan sulfates may regulate the activity of FGF-7 by a different mechanism than other FGFs.	Heparitin Sulfate	50-66	fibroblast growth factor 7	Homo sapiens	96-101
9407232-9	1997	CONCLUSIONS: These experiments demonstrate that FGF-2 is effective in promoting herpetic epithelial ulcer healing, either due to its proliferative effects on epithelial cells or indirectly by occupying the sites on cell surface heparan sulfate necessary for the attachment of the virion.	Heparitin Sulfate	228-243	fibroblast growth factor 2	Homo sapiens	48-53
9425437-1	1997	Hurler syndrome (mucopolysaccharidosis IH or MPS IH) is a congenital mucopolysaccharide storage disorder resulting from a genetic deficiency of alpha-L-iduronidase (IDUA), which is required for lysosomal degradation of glycosaminoglycans heparan sulfate and dermatan sulfate.	Heparitin Sulfate	238-253	alpha-L-iduronidase	Homo sapiens	144-163
9425437-1	1997	Hurler syndrome (mucopolysaccharidosis IH or MPS IH) is a congenital mucopolysaccharide storage disorder resulting from a genetic deficiency of alpha-L-iduronidase (IDUA), which is required for lysosomal degradation of glycosaminoglycans heparan sulfate and dermatan sulfate.	Heparitin Sulfate	238-253	alpha-L-iduronidase	Homo sapiens	165-169
9466688-2	1997	Different effects of the manipulation of cellular heparan sulfates and heparin on activities of FGF-7 relative to FGF-1 in epithelial cells suggest that pericellular heparan sulfates may regulate the activity of FGF-7 by a different mechanism than other FGFs.	Heparitin Sulfate	50-66	fibroblast growth factor 7	Homo sapiens	212-217
9466688-2	1997	Different effects of the manipulation of cellular heparan sulfates and heparin on activities of FGF-7 relative to FGF-1 in epithelial cells suggest that pericellular heparan sulfates may regulate the activity of FGF-7 by a different mechanism than other FGFs.	Heparitin Sulfate	166-182	fibroblast growth factor 7	Homo sapiens	96-101
9466688-2	1997	Different effects of the manipulation of cellular heparan sulfates and heparin on activities of FGF-7 relative to FGF-1 in epithelial cells suggest that pericellular heparan sulfates may regulate the activity of FGF-7 by a different mechanism than other FGFs.	Heparitin Sulfate	166-182	fibroblast growth factor 7	Homo sapiens	212-217
9466688-7	1997	These results suggest that, similar to other FGF polypeptides, heparan sulfate within the pericellular matrix is required for activity of FGF-7.	Heparitin Sulfate	63-78	fibroblast growth factor 1	Homo sapiens	45-48
9422980-3	1997	In this study the expression of HSPG was examined during wound healing in human skin, using monoclonal antibodies (MAbs) that recognize the HSPG core protein and two different heparan sulphate (HS) epitopes, and the dynamics of HSPG expression were investigated in relation to epidermal cellular proliferation and permeability of the BM.	Heparitin Sulfate	176-192	syndecan 2	Homo sapiens	32-36
9466688-7	1997	These results suggest that, similar to other FGF polypeptides, heparan sulfate within the pericellular matrix is required for activity of FGF-7.	Heparitin Sulfate	63-78	fibroblast growth factor 7	Homo sapiens	138-143
9466688-8	1997	Differences in response to heparin and alterations in the BULK heparan sulfate content of cells likely reflect FGF-specific differences in the cellular repertoire of multivalent heparan sulfate chains required for assembly and activation of the FGF signal transduction complex.	Heparitin Sulfate	63-78	fibroblast growth factor 1	Homo sapiens	111-114
9466688-8	1997	Differences in response to heparin and alterations in the BULK heparan sulfate content of cells likely reflect FGF-specific differences in the cellular repertoire of multivalent heparan sulfate chains required for assembly and activation of the FGF signal transduction complex.	Heparitin Sulfate	63-78	fibroblast growth factor 1	Homo sapiens	245-248
9466688-8	1997	Differences in response to heparin and alterations in the BULK heparan sulfate content of cells likely reflect FGF-specific differences in the cellular repertoire of multivalent heparan sulfate chains required for assembly and activation of the FGF signal transduction complex.	Heparitin Sulfate	178-193	fibroblast growth factor 1	Homo sapiens	111-114
9466688-8	1997	Differences in response to heparin and alterations in the BULK heparan sulfate content of cells likely reflect FGF-specific differences in the cellular repertoire of multivalent heparan sulfate chains required for assembly and activation of the FGF signal transduction complex.	Heparitin Sulfate	178-193	fibroblast growth factor 1	Homo sapiens	245-248
9379060-2	1997	Enzyme digestion of heparan sulfate (HS), but not chondroitin sulfate, from the surface of PM1(CD26H) cells (a human T cell line selected for high CD26 expression) rendered them resistant to the antiviral effects of RANTES and macrophage-inflammatory protein-1beta at otherwise inhibitory chemokine concentrations.	Heparitin Sulfate	20-35	transmembrane protein 11	Homo sapiens	91-94
9379060-2	1997	Enzyme digestion of heparan sulfate (HS), but not chondroitin sulfate, from the surface of PM1(CD26H) cells (a human T cell line selected for high CD26 expression) rendered them resistant to the antiviral effects of RANTES and macrophage-inflammatory protein-1beta at otherwise inhibitory chemokine concentrations.	Heparitin Sulfate	20-35	dipeptidyl peptidase 4	Homo sapiens	95-99
9379060-2	1997	Enzyme digestion of heparan sulfate (HS), but not chondroitin sulfate, from the surface of PM1(CD26H) cells (a human T cell line selected for high CD26 expression) rendered them resistant to the antiviral effects of RANTES and macrophage-inflammatory protein-1beta at otherwise inhibitory chemokine concentrations.	Heparitin Sulfate	20-35	C-C motif chemokine ligand 5	Homo sapiens	216-222
9379060-2	1997	Enzyme digestion of heparan sulfate (HS), but not chondroitin sulfate, from the surface of PM1(CD26H) cells (a human T cell line selected for high CD26 expression) rendered them resistant to the antiviral effects of RANTES and macrophage-inflammatory protein-1beta at otherwise inhibitory chemokine concentrations.	Heparitin Sulfate	20-35	C-C motif chemokine ligand 4 like 2	Homo sapiens	227-264
9379060-2	1997	Enzyme digestion of heparan sulfate (HS), but not chondroitin sulfate, from the surface of PM1(CD26H) cells (a human T cell line selected for high CD26 expression) rendered them resistant to the antiviral effects of RANTES and macrophage-inflammatory protein-1beta at otherwise inhibitory chemokine concentrations.	Heparitin Sulfate	37-39	transmembrane protein 11	Homo sapiens	91-94
9379060-2	1997	Enzyme digestion of heparan sulfate (HS), but not chondroitin sulfate, from the surface of PM1(CD26H) cells (a human T cell line selected for high CD26 expression) rendered them resistant to the antiviral effects of RANTES and macrophage-inflammatory protein-1beta at otherwise inhibitory chemokine concentrations.	Heparitin Sulfate	37-39	dipeptidyl peptidase 4	Homo sapiens	95-99
9379060-2	1997	Enzyme digestion of heparan sulfate (HS), but not chondroitin sulfate, from the surface of PM1(CD26H) cells (a human T cell line selected for high CD26 expression) rendered them resistant to the antiviral effects of RANTES and macrophage-inflammatory protein-1beta at otherwise inhibitory chemokine concentrations.	Heparitin Sulfate	37-39	C-C motif chemokine ligand 5	Homo sapiens	216-222
9379060-2	1997	Enzyme digestion of heparan sulfate (HS), but not chondroitin sulfate, from the surface of PM1(CD26H) cells (a human T cell line selected for high CD26 expression) rendered them resistant to the antiviral effects of RANTES and macrophage-inflammatory protein-1beta at otherwise inhibitory chemokine concentrations.	Heparitin Sulfate	37-39	C-C motif chemokine ligand 4 like 2	Homo sapiens	227-264
9379060-5	1997	However, the binding of RANTES to activated macrophages occurred only at higher concentrations (100-300 nM) and was mostly chondroitin sulfate, and not HS, dependent.	Heparitin Sulfate	152-154	C-C motif chemokine ligand 5	Homo sapiens	24-30
9335533-0	1997	Heparan sulfate proteoglycan-mediated uptake of apolipoprotein E-triglyceride-rich lipoprotein particles: a major pathway at physiological particle concentrations.	Heparitin Sulfate	0-15	apolipoprotein E	Homo sapiens	48-64
9526950-4	1997	It was revealed that the high molecular weight subclass of heparan sulfate proteoglycans in the cell layer was markedly decreased by thrombin without changes of the hydrodynamic size of the molecules and the molecular weight of heparan sulfate chains.	Heparitin Sulfate	59-74	coagulation factor II, thrombin	Homo sapiens	133-141
9526950-6	1997	The present data suggest that thrombin-induced decrease in the amount of heparan sulfate in vascular endothelial cell layer includes a reduction of the number of large heparan sulfate proteoglycan perlecan molecules through a suppression of the core protein synthesis.	Heparitin Sulfate	73-88	coagulation factor II, thrombin	Homo sapiens	30-38
9341129-7	1997	Heparinase and heparitinase treatment of cells reduced binding of DCC-Ig, suggesting that heparan sulfate proteoglycans are cell-surface DCC ligand(s).	Heparitin Sulfate	90-105	DCC netrin 1 receptor	Homo sapiens	66-69
9341129-7	1997	Heparinase and heparitinase treatment of cells reduced binding of DCC-Ig, suggesting that heparan sulfate proteoglycans are cell-surface DCC ligand(s).	Heparitin Sulfate	90-105	DCC netrin 1 receptor	Homo sapiens	137-140
9341129-8	1997	This was further supported by heparin blocking experiments and by binding of DCC-Ig to immobilized heparan sulfate.	Heparitin Sulfate	99-114	DCC netrin 1 receptor	Homo sapiens	77-80
9341129-9	1997	The interaction between DCC-Ig and heparan sulfate/heparin, both on the surface of cells and immobilized on plastic, was blocked by the same anti-DCC antibody that blocks netrin-1-dependent commissural axon outgrowth.	Heparitin Sulfate	35-50	DCC netrin 1 receptor	Homo sapiens	24-27
9341129-9	1997	The interaction between DCC-Ig and heparan sulfate/heparin, both on the surface of cells and immobilized on plastic, was blocked by the same anti-DCC antibody that blocks netrin-1-dependent commissural axon outgrowth.	Heparitin Sulfate	35-50	DCC netrin 1 receptor	Homo sapiens	146-149
9341129-9	1997	The interaction between DCC-Ig and heparan sulfate/heparin, both on the surface of cells and immobilized on plastic, was blocked by the same anti-DCC antibody that blocks netrin-1-dependent commissural axon outgrowth.	Heparitin Sulfate	35-50	netrin 1	Homo sapiens	171-179
9343372-0	1997	Interaction of fibroblast growth factor-1 and related peptides with heparan sulfate and its oligosaccharides.	Heparitin Sulfate	68-83	fibroblast growth factor 1	Homo sapiens	15-41
9343372-4	1997	FGF-1 was also shown to protect sequences in heparan sulfate from heparin lyase digestion and protected oligosaccharide products of octasaccharide and decasaccharide size were recovered by FGF-1 affinity chromatography, suggesting that the high-affinity binding of heparan sulfate to FGF-1 resides within an octasaccharide sequence.	Heparitin Sulfate	265-280	fibroblast growth factor 1	Homo sapiens	0-5
9343372-4	1997	FGF-1 was also shown to protect sequences in heparan sulfate from heparin lyase digestion and protected oligosaccharide products of octasaccharide and decasaccharide size were recovered by FGF-1 affinity chromatography, suggesting that the high-affinity binding of heparan sulfate to FGF-1 resides within an octasaccharide sequence.	Heparitin Sulfate	265-280	fibroblast growth factor 1	Homo sapiens	189-194
9343372-3	1997	The interaction of fibroblast growth factor-1 (FGF-1 or aFGF) using heparin lyase-derived oligosaccharides from heparan sulfate was investigated.	Heparitin Sulfate	112-127	fibroblast growth factor 1	Homo sapiens	19-45
9343372-4	1997	FGF-1 was also shown to protect sequences in heparan sulfate from heparin lyase digestion and protected oligosaccharide products of octasaccharide and decasaccharide size were recovered by FGF-1 affinity chromatography, suggesting that the high-affinity binding of heparan sulfate to FGF-1 resides within an octasaccharide sequence.	Heparitin Sulfate	265-280	fibroblast growth factor 1	Homo sapiens	189-194
9343372-3	1997	The interaction of fibroblast growth factor-1 (FGF-1 or aFGF) using heparin lyase-derived oligosaccharides from heparan sulfate was investigated.	Heparitin Sulfate	112-127	fibroblast growth factor 1	Homo sapiens	47-52
9343372-5	1997	The FGF-1 binding affinity of heparan sulfate is reduced compared to heparin presumably due to the absence of 6-sulfate groups in heparan sulfate.	Heparitin Sulfate	30-45	fibroblast growth factor 1	Homo sapiens	4-9
9343372-5	1997	The FGF-1 binding affinity of heparan sulfate is reduced compared to heparin presumably due to the absence of 6-sulfate groups in heparan sulfate.	Heparitin Sulfate	130-145	fibroblast growth factor 1	Homo sapiens	4-9
9343372-3	1997	The interaction of fibroblast growth factor-1 (FGF-1 or aFGF) using heparin lyase-derived oligosaccharides from heparan sulfate was investigated.	Heparitin Sulfate	112-127	fibroblast growth factor 1	Homo sapiens	56-60
9343372-6	1997	Inspection of the FGF-1 heparan sulfate binding domain shows that the majority of interacting amino acids are contained within a 20-amino-acid sequence that folds back upon itself (because of three turns) forming a triangular shaped cup of positive charge.	Heparitin Sulfate	24-39	fibroblast growth factor 1	Homo sapiens	18-23
9343372-8	1997	Heparan sulfate affinity chromatography and isothermal titration calorimetry, used to measure binding thermodynamics, demonstrated that a synthetic peptide analogous to the GAG binding site in FGF-1 bound tightly to heparan sulfate.	Heparitin Sulfate	0-15	fibroblast growth factor 1	Homo sapiens	193-198
9359422-1	1997	Previous studies have indicated that CD44 isoforms, spliced with variant exons, are heterogeneously glycanated with chondroitin sulphate and heparan sulphate chains.	Heparitin Sulfate	141-157	CD44 molecule (Indian blood group)	Homo sapiens	37-41
9343372-8	1997	Heparan sulfate affinity chromatography and isothermal titration calorimetry, used to measure binding thermodynamics, demonstrated that a synthetic peptide analogous to the GAG binding site in FGF-1 bound tightly to heparan sulfate.	Heparitin Sulfate	216-231	fibroblast growth factor 1	Homo sapiens	193-198
9343372-4	1997	FGF-1 was also shown to protect sequences in heparan sulfate from heparin lyase digestion and protected oligosaccharide products of octasaccharide and decasaccharide size were recovered by FGF-1 affinity chromatography, suggesting that the high-affinity binding of heparan sulfate to FGF-1 resides within an octasaccharide sequence.	Heparitin Sulfate	45-60	fibroblast growth factor 1	Homo sapiens	0-5
9343372-10	1997	A cyclic peptide, expected to be topologically most similar to the triangular GAG binding site in FGF-1, bound with the highest affinity to heparan sulfate.	Heparitin Sulfate	140-155	fibroblast growth factor 1	Homo sapiens	98-103
9391721-1	1997	The aim of this work was to clarify the role of urokinase-type plasminogen activator (uPA) on the profibrinolytic activity of heparin, chemically modified heparins [partially: N-desulfated (N-des), N-desulfated N-acetylated (N-des N-ac), O-desulfated (O-des), O/N-desulfated N-acetylated (O/N-des N-ac)] and heparan sulfate.	Heparitin Sulfate	308-323	plasminogen activator, urokinase	Mus musculus	48-84
9343372-11	1997	These data suggest the triangular topology of the GAG binding site in FGF is critical for its interaction with heparan sulfate.	Heparitin Sulfate	111-126	fibroblast growth factor 1	Homo sapiens	70-73
9351360-4	1997	The mitogenic effect of HB-EGF was greater when incubated with heparan sulfate (HS) isolated from SMCs cultured in high glucose than with HS from cells cultured in low glucose.	Heparitin Sulfate	63-78	heparin-binding EGF-like growth factor	Rattus norvegicus	24-30
9351360-4	1997	The mitogenic effect of HB-EGF was greater when incubated with heparan sulfate (HS) isolated from SMCs cultured in high glucose than with HS from cells cultured in low glucose.	Heparitin Sulfate	80-82	heparin-binding EGF-like growth factor	Rattus norvegicus	24-30
9351360-4	1997	The mitogenic effect of HB-EGF was greater when incubated with heparan sulfate (HS) isolated from SMCs cultured in high glucose than with HS from cells cultured in low glucose.	Heparitin Sulfate	138-140	heparin-binding EGF-like growth factor	Rattus norvegicus	24-30
9355727-6	1997	Principal functions of the syndecan core proteins are to target the heparan sulphate chains to the appropriate plasma-membrane compartment and to interact with components of the actin-based cytoskeleton.	Heparitin Sulfate	68-84	syndecan 1	Homo sapiens	27-35
9391721-1	1997	The aim of this work was to clarify the role of urokinase-type plasminogen activator (uPA) on the profibrinolytic activity of heparin, chemically modified heparins [partially: N-desulfated (N-des), N-desulfated N-acetylated (N-des N-ac), O-desulfated (O-des), O/N-desulfated N-acetylated (O/N-des N-ac)] and heparan sulfate.	Heparitin Sulfate	308-323	plasminogen activator, urokinase	Mus musculus	86-89
9391721-4	1997	In contrast, all chemically-modified heparins lacked this cofactor activity, although N-des and heparan sulfate partially retained the uPA binding capacity, and O-des partially bound to both plasminogen and uPA.	Heparitin Sulfate	96-111	plasminogen activator, urokinase	Mus musculus	135-138
9328841-5	1997	In addition, heparan sulfate drastically inhibited [125I]DCN binding to solid-phase adsorbed TSP (80% inhibition), suggesting that DCN could bind to the N-terminal domain of TSP through interaction with heparin-binding sequences.	Heparitin Sulfate	13-28	decorin	Homo sapiens	57-60
9328841-5	1997	In addition, heparan sulfate drastically inhibited [125I]DCN binding to solid-phase adsorbed TSP (80% inhibition), suggesting that DCN could bind to the N-terminal domain of TSP through interaction with heparin-binding sequences.	Heparitin Sulfate	13-28	thrombospondin 1	Homo sapiens	93-96
9328841-5	1997	In addition, heparan sulfate drastically inhibited [125I]DCN binding to solid-phase adsorbed TSP (80% inhibition), suggesting that DCN could bind to the N-terminal domain of TSP through interaction with heparin-binding sequences.	Heparitin Sulfate	13-28	decorin	Homo sapiens	131-134
9328841-5	1997	In addition, heparan sulfate drastically inhibited [125I]DCN binding to solid-phase adsorbed TSP (80% inhibition), suggesting that DCN could bind to the N-terminal domain of TSP through interaction with heparin-binding sequences.	Heparitin Sulfate	13-28	thrombospondin 1	Homo sapiens	174-177
9350282-9	1997	The glycosaminoglycans heparan sulfate and heparin, which bind SAP, reduced SAPs binding to the virus.	Heparitin Sulfate	23-38	amyloid P component, serum	Homo sapiens	63-66
9374919-12	1997	The lack of a parallel increase of TAT with F1 + 2, in the presence of normal levels of antithrombin III (ATIII), indirectly suggests an impairment of the heparan sulphate-ATIII system which would favour thrombin generation.	Heparitin Sulfate	155-171	serpin family C member 1	Homo sapiens	172-177
9254627-3	1997	Heparan sulfate is an initial binding site for HGF, based on its relative abundance on the cell surface.	Heparitin Sulfate	0-15	hepatocyte growth factor	Homo sapiens	47-50
9279289-7	1997	RESULTS: Danaparoid displaced significantly less biotinylated heparan sulphate from triglyceride-rich lipoprotein-lipoprotein lipase complexes in vitro than heparin.	Heparitin Sulfate	62-78	lipoprotein lipase	Homo sapiens	114-132
9242510-5	1997	Immunoprecipitates digested with heparitinase lost 40-68% of incorporated 35SO4 and 24-40% of [3H]glucosamine, indicating that heparan sulfate was the predominant glycosaminoglycan in epidermal CD44.	Heparitin Sulfate	127-142	CD44 molecule (Indian blood group)	Homo sapiens	194-198
9242510-13	1997	Therefore, the large heparan sulfate-substituted CD44 forms a significant part of all proteoglycans in normal human epidermis.	Heparitin Sulfate	21-36	CD44 molecule (Indian blood group)	Homo sapiens	49-53
9258342-2	1997	Binding of bFGF to heparin or heparan sulfate has been demonstrated to both stimulate and inhibit growth factor activity.	Heparitin Sulfate	30-45	fibroblast growth factor 2	Homo sapiens	11-15
9188470-12	1997	LpL released by lyso-ECCM remained stable and did not lose enzymatic activity at 37 degrees C for 1 h. LpL activity was also stabilized by heparanase-digested fragments of HS (HS oligosaccharide) and by purified LpL binding decasaccharide.	Heparitin Sulfate	172-174	lipoprotein lipase	Homo sapiens	0-3
9487024-9	1997	Incubation of 70W cells with NGF or NT-3, but not BDNF, NT-4/5, or mutant NGF, resulted in increased release of heparanase activity that was capable of degrading a subpopulation of heparan sulfate molecules.	Heparitin Sulfate	181-196	nerve growth factor	Homo sapiens	29-32
9240182-6	1997	HPLC showed that CSBS contained a small amount of dermatan sulphate and abundant heparan sulphate, both of which inhibited crystal growth.	Heparitin Sulfate	81-97	filamin A	Homo sapiens	17-21
9240182-7	1997	CONCLUSION: Both heparan sulphate and dermatan sulphate may inhibit calcium oxalate crystallization, the former being the predominant GAG in CSBS.	Heparitin Sulfate	17-33	filamin A	Homo sapiens	141-145
9202242-2	1997	The ECM-IGFBP-5 interaction is mediated in part by binding to heparan sulfate containing proteoglycans.	Heparitin Sulfate	62-77	insulin like growth factor binding protein 5	Homo sapiens	8-15
9202242-12	1997	Heparin and heparan sulfate inhibited the IGFBP-5/PAI-1 interaction; however, several other glycosaminoglycans had no effect.	Heparitin Sulfate	12-27	insulin like growth factor binding protein 5	Homo sapiens	42-49
9202242-12	1997	Heparin and heparan sulfate inhibited the IGFBP-5/PAI-1 interaction; however, several other glycosaminoglycans had no effect.	Heparitin Sulfate	12-27	serpin family E member 1	Homo sapiens	50-55
9188488-0	1997	Heparanase and a synthetic peptide of heparan sulfate-interacting protein recognize common sites on cell surface and extracellular matrix heparan sulfate.	Heparitin Sulfate	38-53	heparanase	Homo sapiens	0-10
9188488-0	1997	Heparanase and a synthetic peptide of heparan sulfate-interacting protein recognize common sites on cell surface and extracellular matrix heparan sulfate.	Heparitin Sulfate	138-153	heparanase	Homo sapiens	0-10
9188488-1	1997	Heparanase is an endo-beta-D-glucuronidase that degrades the glycosaminoglycan chains of heparan sulfate (HS) proteoglycans at specific sites.	Heparitin Sulfate	89-104	heparanase	Homo sapiens	0-10
9188488-1	1997	Heparanase is an endo-beta-D-glucuronidase that degrades the glycosaminoglycan chains of heparan sulfate (HS) proteoglycans at specific sites.	Heparitin Sulfate	89-104	glucuronidase beta	Homo sapiens	22-42
9218427-1	1997	We have undertaken a comparative study of the interaction of the three mammalian transforming growth factor-betas (TGF-beta) with heparin and heparan sulfate.	Heparitin Sulfate	142-157	transforming growth factor beta 1	Homo sapiens	115-123
9218427-2	1997	TGF-beta1 and -beta2, but not -beta3, bind to heparin and the highly sulfated liver heparan sulfate.	Heparitin Sulfate	84-99	transforming growth factor beta 1	Homo sapiens	0-20
9218427-5	1997	TGF-beta2.alpha2-macroglobulin complexes are more refractory to heparin/heparan sulfate, and those involving TGF-beta3 cannot be affected.	Heparitin Sulfate	72-87	alpha-2-macroglobulin	Homo sapiens	10-30
9278150-2	1997	In the present study the influence of undersulfated heparan sulfate on the expression of basic fibroblast growth factor and coronary smooth muscle cell (cSMC) proliferation was investigated.	Heparitin Sulfate	52-67	fibroblast growth factor 2	Homo sapiens	89-119
9278150-12	1997	Our results demonstrate an inverse association between the sulfation of heparan sulfate and the expression of bFGF.	Heparitin Sulfate	72-87	fibroblast growth factor 2	Homo sapiens	110-114
9199199-2	1997	The binding site in heparin and heparan sulfate for fibroblast growth factor-2 (basic fibroblast growth factor) has been described as rich in glucosamine-2-sulfate 1--&gt;4 linked to iduronic acid-2-sulfate.	Heparitin Sulfate	32-47	fibroblast growth factor 2	Homo sapiens	52-78
9188488-3	1997	We previously reported heparanase degradation of cell surface HS subpopulations of the human adenocarcinoma cell line RL95.	Heparitin Sulfate	62-64	heparanase	Homo sapiens	23-33
9188488-4	1997	In the present study, heparanase activity was examined on RL95 cell surface HS subpopulations in the presence of a synthetic peptide (CRPKAKAKAKAKDQTK) of heparin/heparan sulfate-interacting protein (HIP; Liu, S., Smith, S. E., Julian, J., Rohde, L. H., Karin, N. J., and Carson, D. D. (1996) J. Biol.	Heparitin Sulfate	76-78	heparanase	Homo sapiens	22-32
9188488-4	1997	In the present study, heparanase activity was examined on RL95 cell surface HS subpopulations in the presence of a synthetic peptide (CRPKAKAKAKAKDQTK) of heparin/heparan sulfate-interacting protein (HIP; Liu, S., Smith, S. E., Julian, J., Rohde, L. H., Karin, N. J., and Carson, D. D. (1996) J. Biol.	Heparitin Sulfate	163-178	heparanase	Homo sapiens	22-32
9188470-12	1997	LpL released by lyso-ECCM remained stable and did not lose enzymatic activity at 37 degrees C for 1 h. LpL activity was also stabilized by heparanase-digested fragments of HS (HS oligosaccharide) and by purified LpL binding decasaccharide.	Heparitin Sulfate	172-174	lipoprotein lipase	Homo sapiens	103-106
9188488-10	1997	Conversely, predigestion of cell surface HS with either heparanase-containing cellular extracts or with secreted or partially purified heparanase destroyed binding to HIP peptide.	Heparitin Sulfate	41-43	heparanase	Homo sapiens	56-66
9188488-10	1997	Conversely, predigestion of cell surface HS with either heparanase-containing cellular extracts or with secreted or partially purified heparanase destroyed binding to HIP peptide.	Heparitin Sulfate	41-43	heparanase	Homo sapiens	135-145
9188470-12	1997	LpL released by lyso-ECCM remained stable and did not lose enzymatic activity at 37 degrees C for 1 h. LpL activity was also stabilized by heparanase-digested fragments of HS (HS oligosaccharide) and by purified LpL binding decasaccharide.	Heparitin Sulfate	172-174	lipoprotein lipase	Homo sapiens	103-106
9221948-0	1997	Heparan sulfate modifies the effects of basic fibroblast growth factor on glial reactivity.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Rattus norvegicus	40-70
9186300-0	1997	Lipoprotein lipase-enhanced binding of lipoprotein(a) [Lp(a)] to heparan sulfate is improved by apolipoprotein E (apoE) saturation: secretion-capture process of apoE is a possible route for the catabolism of Lp(a).	Heparitin Sulfate	65-80	lipoprotein lipase	Bos taurus	0-18
9186300-0	1997	Lipoprotein lipase-enhanced binding of lipoprotein(a) [Lp(a)] to heparan sulfate is improved by apolipoprotein E (apoE) saturation: secretion-capture process of apoE is a possible route for the catabolism of Lp(a).	Heparitin Sulfate	65-80	plasminogen	Bos taurus	39-53
9186300-0	1997	Lipoprotein lipase-enhanced binding of lipoprotein(a) [Lp(a)] to heparan sulfate is improved by apolipoprotein E (apoE) saturation: secretion-capture process of apoE is a possible route for the catabolism of Lp(a).	Heparitin Sulfate	65-80	plasminogen	Bos taurus	55-60
9186300-0	1997	Lipoprotein lipase-enhanced binding of lipoprotein(a) [Lp(a)] to heparan sulfate is improved by apolipoprotein E (apoE) saturation: secretion-capture process of apoE is a possible route for the catabolism of Lp(a).	Heparitin Sulfate	65-80	apolipoprotein E	Bos taurus	96-112
9201711-7	1997	Finally, the Oct-1-suppressing activity of EHS-BM was sensitive to heparinase digestion but not to chondroitinase ABC or hyaluronidase digestion, suggesting that the heparan sulfate side chains of perlecan play a biologically important role in negatively regulating the expression of Oct-1 transcripts.	Heparitin Sulfate	166-181	solute carrier family 22 member 1	Homo sapiens	13-18
9186300-0	1997	Lipoprotein lipase-enhanced binding of lipoprotein(a) [Lp(a)] to heparan sulfate is improved by apolipoprotein E (apoE) saturation: secretion-capture process of apoE is a possible route for the catabolism of Lp(a).	Heparitin Sulfate	65-80	apolipoprotein E	Bos taurus	114-118
9186300-0	1997	Lipoprotein lipase-enhanced binding of lipoprotein(a) [Lp(a)] to heparan sulfate is improved by apolipoprotein E (apoE) saturation: secretion-capture process of apoE is a possible route for the catabolism of Lp(a).	Heparitin Sulfate	65-80	apolipoprotein E	Bos taurus	161-165
9186300-0	1997	Lipoprotein lipase-enhanced binding of lipoprotein(a) [Lp(a)] to heparan sulfate is improved by apolipoprotein E (apoE) saturation: secretion-capture process of apoE is a possible route for the catabolism of Lp(a).	Heparitin Sulfate	65-80	plasminogen	Bos taurus	208-213
9186300-2	1997	Two mediators of lipoprotein catabolism, both with HS binding capacity, lipoprotein lipase (LPL) and apolipoprotein E (apoE), are involved in this process.	Heparitin Sulfate	51-53	lipoprotein lipase	Bos taurus	72-90
9186300-2	1997	Two mediators of lipoprotein catabolism, both with HS binding capacity, lipoprotein lipase (LPL) and apolipoprotein E (apoE), are involved in this process.	Heparitin Sulfate	51-53	lipoprotein lipase	Bos taurus	92-95
9186300-2	1997	Two mediators of lipoprotein catabolism, both with HS binding capacity, lipoprotein lipase (LPL) and apolipoprotein E (apoE), are involved in this process.	Heparitin Sulfate	51-53	apolipoprotein E	Bos taurus	101-117
9186300-2	1997	Two mediators of lipoprotein catabolism, both with HS binding capacity, lipoprotein lipase (LPL) and apolipoprotein E (apoE), are involved in this process.	Heparitin Sulfate	51-53	apolipoprotein E	Bos taurus	119-123
9153241-1	1997	Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate.	Heparitin Sulfate	100-115	follistatin	Rattus norvegicus	59-70
9164872-7	1997	In a concentration-dependent fashion, PAI-1, CaCl2, heparin and heparan sulphate, but not other glycosaminoglycans, interfered with the binding of vitronectin to osteonectin.	Heparitin Sulfate	64-80	serpin family E member 1	Homo sapiens	38-43
9164872-7	1997	In a concentration-dependent fashion, PAI-1, CaCl2, heparin and heparan sulphate, but not other glycosaminoglycans, interfered with the binding of vitronectin to osteonectin.	Heparitin Sulfate	64-80	vitronectin	Homo sapiens	147-158
9136889-11	1997	Binding of LDL, VLDL, and chylomicrons to heparan sulfate-covered surfaces, both in the presence and in the absence of lipoprotein lipase, was characterized by high values for association rate constants (10(4)-10(5) M(-1) s(-1)) and low values for dissociation rate constants (10(-4)-10(-5) M(-1) s(-1)).	Heparitin Sulfate	42-57	lipoprotein lipase	Homo sapiens	119-137
9139688-8	1997	Addition of purified soluble glypican effectively replaced heparin in supporting basic FGF-induced cellular proliferation of heparan sulfate-negative cells expressing recombinant FGF receptor-1.	Heparitin Sulfate	125-140	glypican 1	Homo sapiens	29-37
9139688-8	1997	Addition of purified soluble glypican effectively replaced heparin in supporting basic FGF-induced cellular proliferation of heparan sulfate-negative cells expressing recombinant FGF receptor-1.	Heparitin Sulfate	125-140	fibroblast growth factor 7	Rattus norvegicus	87-90
9139688-8	1997	Addition of purified soluble glypican effectively replaced heparin in supporting basic FGF-induced cellular proliferation of heparan sulfate-negative cells expressing recombinant FGF receptor-1.	Heparitin Sulfate	125-140	Fibroblast growth factor receptor 1	Rattus norvegicus	179-193
9174666-4	1997	When present in the culture medium, the ganglioside sialidase inhibitors 2-deoxy-2,3-dehydro-N-acetylneuraminic acid (NeuAc2en), heparin, and heparan sulfate caused dramatic changes in cell behavior.	Heparitin Sulfate	142-157	neuraminidase 3	Homo sapiens	40-61
9251237-4	1997	The diverse functions of heparan sulphate, which range from the control of blood coagulation to the regulation of cell growth and adhesion, depend on the capacity of the chains to activate protein ligands, such as antithrombin III and members of the fibroblast growth factor family.	Heparitin Sulfate	25-41	serpin family C member 1	Homo sapiens	214-230
9139688-2	1997	We have reported previously that cell-associated heparan sulfates inhibit the binding of the keratinocyte growth factor (KGF), but enhance the binding of acidic FGF to the KGF receptor, both in keratinocytes, which naturally express this receptor, and in rat myoblasts, which ectopically express it (Reich-Slotky, R., Bonneh-Barkay, D., Shaoul, E., Berman, B., Svahn, C. M., and Ron, D. (1994) J. Biol.	Heparitin Sulfate	49-65	fibroblast growth factor 7	Rattus norvegicus	93-119
9139688-2	1997	We have reported previously that cell-associated heparan sulfates inhibit the binding of the keratinocyte growth factor (KGF), but enhance the binding of acidic FGF to the KGF receptor, both in keratinocytes, which naturally express this receptor, and in rat myoblasts, which ectopically express it (Reich-Slotky, R., Bonneh-Barkay, D., Shaoul, E., Berman, B., Svahn, C. M., and Ron, D. (1994) J. Biol.	Heparitin Sulfate	49-65	fibroblast growth factor 7	Rattus norvegicus	121-124
9139688-2	1997	We have reported previously that cell-associated heparan sulfates inhibit the binding of the keratinocyte growth factor (KGF), but enhance the binding of acidic FGF to the KGF receptor, both in keratinocytes, which naturally express this receptor, and in rat myoblasts, which ectopically express it (Reich-Slotky, R., Bonneh-Barkay, D., Shaoul, E., Berman, B., Svahn, C. M., and Ron, D. (1994) J. Biol.	Heparitin Sulfate	49-65	fibroblast growth factor 7	Rattus norvegicus	172-175
9139688-5	1997	The proteoglycan bearing these modulatory heparan sulfates was purified to homogeneity from salt extracts of rat myoblasts by anion-exchange and FGF affinity chromatography and was identified as rat glypican.	Heparitin Sulfate	42-58	glypican 1	Homo sapiens	199-207
9165101-3	1997	An increase in the dose-dependent binding of SAP to heparan sulfate, AA-protein and beta2M was observed as the pH decreased from 8.0 to 5.0.	Heparitin Sulfate	52-67	amyloid P component, serum	Homo sapiens	45-48
9111037-7	1997	Heparin and heparan sulfate (HS), but not dermatan sulfate, chondroitin sulfates A and C, hyaluronic acid, and K5 polysaccharide, competed with 3H-labeled heparin for binding to immobilized GST-Tat and inhibited HIV-LTR transactivation induced by extracellular GST-Tat.	Heparitin Sulfate	12-27	tyrosine aminotransferase	Homo sapiens	194-197
9111037-7	1997	Heparin and heparan sulfate (HS), but not dermatan sulfate, chondroitin sulfates A and C, hyaluronic acid, and K5 polysaccharide, competed with 3H-labeled heparin for binding to immobilized GST-Tat and inhibited HIV-LTR transactivation induced by extracellular GST-Tat.	Heparitin Sulfate	12-27	Tat	Human immunodeficiency virus 1	265-268
9111037-7	1997	Heparin and heparan sulfate (HS), but not dermatan sulfate, chondroitin sulfates A and C, hyaluronic acid, and K5 polysaccharide, competed with 3H-labeled heparin for binding to immobilized GST-Tat and inhibited HIV-LTR transactivation induced by extracellular GST-Tat.	Heparitin Sulfate	29-31	tyrosine aminotransferase	Homo sapiens	194-197
9111037-7	1997	Heparin and heparan sulfate (HS), but not dermatan sulfate, chondroitin sulfates A and C, hyaluronic acid, and K5 polysaccharide, competed with 3H-labeled heparin for binding to immobilized GST-Tat and inhibited HIV-LTR transactivation induced by extracellular GST-Tat.	Heparitin Sulfate	29-31	Tat	Human immunodeficiency virus 1	265-268
9111037-13	1997	The Tat binding activity of the glycosaminoglycans tested correlates with their capacity to affect the transactivating activity of extracellular Tat, indicating the possibility to design specific heparin/HS-like structures with Tat-antagonist activity.	Heparitin Sulfate	204-206	tyrosine aminotransferase	Homo sapiens	4-7
9111037-13	1997	The Tat binding activity of the glycosaminoglycans tested correlates with their capacity to affect the transactivating activity of extracellular Tat, indicating the possibility to design specific heparin/HS-like structures with Tat-antagonist activity.	Heparitin Sulfate	204-206	tyrosine aminotransferase	Homo sapiens	145-148
9111037-13	1997	The Tat binding activity of the glycosaminoglycans tested correlates with their capacity to affect the transactivating activity of extracellular Tat, indicating the possibility to design specific heparin/HS-like structures with Tat-antagonist activity.	Heparitin Sulfate	204-206	tyrosine aminotransferase	Homo sapiens	145-148
9165101-4	1997	Furthermore, a lower, but significant Ca2(+)-independent binding of SAP to heparan sulfate, dermatan sulfate, AA protein and the amyloid precursor protein beta2M was observed.	Heparitin Sulfate	75-90	amyloid P component, serum	Homo sapiens	68-71
9108114-6	1997	Moreover, tau immunoreactivity coexists with heparan sulfate in affected nerve and glial cells.	Heparitin Sulfate	45-60	microtubule associated protein tau	Homo sapiens	10-13
9126805-2	1997	However, IFNgamma binds to heparan sulfate, and is localized by these molecules in a restricted area within the tissue.	Heparitin Sulfate	27-42	interferon gamma	Mus musculus	9-17
9092516-1	1997	HT-29 human colon adenocarcinoma cells adhere rapidly to human angiogenin (Ang) via interactions with cell-surface heparan sulfate moieties (Soncin, F., Shapiro, R., and Fett, J. W. (1994) J. Biol.	Heparitin Sulfate	115-130	angiogenin	Homo sapiens	63-73
9092516-1	1997	HT-29 human colon adenocarcinoma cells adhere rapidly to human angiogenin (Ang) via interactions with cell-surface heparan sulfate moieties (Soncin, F., Shapiro, R., and Fett, J. W. (1994) J. Biol.	Heparitin Sulfate	115-130	angiogenin	Homo sapiens	75-78
9094999-0	1997	Differential binding of fibroblast growth factor-2 and -7 to basement membrane heparan sulfate: comparison of normal and abnormal human tissues.	Heparitin Sulfate	79-94	fibroblast growth factor 2	Homo sapiens	24-57
9094999-4	1997	Using biotinylated FGF-2 and FGF-7 (KGF) as probes, we have identified specific interactions between FGFs and heparan sulfates in human tissues.	Heparitin Sulfate	110-126	fibroblast growth factor 2	Homo sapiens	19-24
9094999-4	1997	Using biotinylated FGF-2 and FGF-7 (KGF) as probes, we have identified specific interactions between FGFs and heparan sulfates in human tissues.	Heparitin Sulfate	110-126	fibroblast growth factor 7	Homo sapiens	29-34
9094999-4	1997	Using biotinylated FGF-2 and FGF-7 (KGF) as probes, we have identified specific interactions between FGFs and heparan sulfates in human tissues.	Heparitin Sulfate	110-126	fibroblast growth factor 7	Homo sapiens	36-39
9094999-7	1997	Although FGF-2 strongly binds to basement membrane heparan sulfate in skin and most other tissue sites examined, FGF-7 fails to bind to basement membrane heparan sulfate in most locations.	Heparitin Sulfate	51-66	fibroblast growth factor 2	Homo sapiens	9-14
9213829-9	1997	Heparansulphate and sulodexide were able to reduce signs and symptoms with similar degree and to significantly modify t-PA, alpha 2-antiplasmin and ATIII levels without any difference between treatments.	Heparitin Sulfate	0-15	plasminogen activator, tissue type	Homo sapiens	118-122
9213829-9	1997	Heparansulphate and sulodexide were able to reduce signs and symptoms with similar degree and to significantly modify t-PA, alpha 2-antiplasmin and ATIII levels without any difference between treatments.	Heparitin Sulfate	0-15	serpin family F member 2	Homo sapiens	124-143
9213829-9	1997	Heparansulphate and sulodexide were able to reduce signs and symptoms with similar degree and to significantly modify t-PA, alpha 2-antiplasmin and ATIII levels without any difference between treatments.	Heparitin Sulfate	0-15	serpin family C member 1	Homo sapiens	148-153
9107173-2	1997	Among the growth factors that promote SMC proliferation is basic fibroblast growth factor (bFGF), which is characterized by a high affinity for heparin and is associated with heparan sulfate on cell surfaces and extracellular matrices.	Heparitin Sulfate	175-190	fibroblast growth factor 2	Homo sapiens	59-89
9107173-2	1997	Among the growth factors that promote SMC proliferation is basic fibroblast growth factor (bFGF), which is characterized by a high affinity for heparin and is associated with heparan sulfate on cell surfaces and extracellular matrices.	Heparitin Sulfate	175-190	fibroblast growth factor 2	Homo sapiens	91-95
9134329-1	1997	PURPOSE: The differential effects of transforming growth factor (TGF) alpha, beta 1 and beta 2 on the de novo localization of heparan sulfate proteoglycan, collagen type VII and laminin-1 to the adhesion complex were analyzed using an in vitro model of corneal epithelial cell wound healing.	Heparitin Sulfate	126-141	transforming growth factor alpha	Bos taurus	37-75
9129989-0	1997	Monoclonal antibody to heparan sulfate from autoimmune tight skin (TSK) mice binds to the endothelial cell surface.	Heparitin Sulfate	23-38	fibrillin 1	Mus musculus	55-65
9129989-0	1997	Monoclonal antibody to heparan sulfate from autoimmune tight skin (TSK) mice binds to the endothelial cell surface.	Heparitin Sulfate	23-38	fibrillin 1	Mus musculus	67-70
9120000-1	1997	Heparan sulfate (HS) proteoglycans play a key role in cell proliferation induced by basic fibroblast growth factor (FGF-2) and other heparin-binding growth factors.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Rattus norvegicus	84-114
9120000-1	1997	Heparan sulfate (HS) proteoglycans play a key role in cell proliferation induced by basic fibroblast growth factor (FGF-2) and other heparin-binding growth factors.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Rattus norvegicus	116-121
9120000-1	1997	Heparan sulfate (HS) proteoglycans play a key role in cell proliferation induced by basic fibroblast growth factor (FGF-2) and other heparin-binding growth factors.	Heparitin Sulfate	17-19	fibroblast growth factor 2	Rattus norvegicus	84-114
9120000-1	1997	Heparan sulfate (HS) proteoglycans play a key role in cell proliferation induced by basic fibroblast growth factor (FGF-2) and other heparin-binding growth factors.	Heparitin Sulfate	17-19	fibroblast growth factor 2	Rattus norvegicus	116-121
9065409-6	1997	This interaction is mediated by the heparan sulfate chains of OCI-5 because it can be inhibited by heparin or by heparitinase.	Heparitin Sulfate	36-51	glypican 3	Rattus norvegicus	62-67
9126805-3	1997	For example, in rat liver, it has been shown that following injection, IFNgamma was concentrated in a restricted area by heparan sulfate.	Heparitin Sulfate	121-136	interferon gamma	Rattus norvegicus	71-79
9126805-12	1997	Since granulomas are almost completely devoid of heparan sulfate, these data could suggest, among others hypotheses, that heparan sulfate which binds IFNgamma either localizes or mediates the cytokine activity outside the granulomas.	Heparitin Sulfate	122-137	interferon gamma	Mus musculus	150-158
9124611-4	1997	The diminished activity of oxidized SLPI could be almost completely restored when an iduronate-containing glycosaminoglycan, such as heparin, heparan sulfate, or dermatan sulfate, was added to the reaction medium.	Heparitin Sulfate	142-157	secretory leukocyte peptidase inhibitor	Homo sapiens	36-40
9093910-11	1997	We demonstrated that HBL-100 and MDA-MB-231 cells bind more FGF-2 to their heparan sulfate proteoglycans than MCF-7 cells.	Heparitin Sulfate	75-90	fibroblast growth factor 2	Homo sapiens	60-65
9067536-3	1997	Radioligand binding assays demonstrated that total binding of 125I-IFN-gamma to the EAhy.926 endothelial hybridoma cell line was reduced in the presence of heparin or heparan sulphate (HS); the structurally dissimilar GAG chondroitin sulphate had no effect.	Heparitin Sulfate	167-183	interferon gamma	Homo sapiens	67-76
9067536-3	1997	Radioligand binding assays demonstrated that total binding of 125I-IFN-gamma to the EAhy.926 endothelial hybridoma cell line was reduced in the presence of heparin or heparan sulphate (HS); the structurally dissimilar GAG chondroitin sulphate had no effect.	Heparitin Sulfate	185-187	interferon gamma	Homo sapiens	67-76
9030584-10	1997	Two types of FGF binding sites were identified: an ionic strength and heparin-independent site that represents FGF binding to CFR290-740 and an additional FGF binding site that is heparan sulfate-dependent and sensitive to high ionic strength.	Heparitin Sulfate	180-195	fibroblast growth factor 10	Gallus gallus	13-16
9048763-1	1997	Recent studies have shown that the binding of the amyloid protein precursor (APP) of Alzheimer"s disease to heparan sulfate proteoglycans (HSPGs) can modulate a neurite outgrowth-promoting function associated with APP.	Heparitin Sulfate	108-123	amyloid beta precursor protein	Homo sapiens	50-75
9106158-7	1997	Compared with the control, an extensive increase in proteoglycan production was generated by the combination of EGF, TGF-beta and PDGF-BB, 7-fold for biglycan, approximately 5-fold for versican and hyaluronan and 2.4-4-fold for heparan sulfate proteoglycan and decorin.	Heparitin Sulfate	228-243	epidermal growth factor	Homo sapiens	112-115
9106158-7	1997	Compared with the control, an extensive increase in proteoglycan production was generated by the combination of EGF, TGF-beta and PDGF-BB, 7-fold for biglycan, approximately 5-fold for versican and hyaluronan and 2.4-4-fold for heparan sulfate proteoglycan and decorin.	Heparitin Sulfate	228-243	transforming growth factor beta 1	Homo sapiens	117-125
9030584-11	1997	This latter site is likely to bind FGF indirectly via heparan sulfate binding to CFR.	Heparitin Sulfate	54-69	fibroblast growth factor 10	Gallus gallus	35-38
9030584-11	1997	This latter site is likely to bind FGF indirectly via heparan sulfate binding to CFR.	Heparitin Sulfate	54-69	golgi glycoprotein 1	Gallus gallus	81-84
9068943-5	1997	Retinas were isolated and HSPG synthesis was assessed by incorporation of 35S-sulfate into heparan sulfate.	Heparitin Sulfate	91-106	syndecan 2	Rattus norvegicus	26-30
9252193-5	1997	Of these, heparan sulphate, eluting as one well-defined peak (referred to as HS1) and another of lower activity and less well defined (HS2), was selected as the most likely to interact with growth factors and cytokines and was isolated from the eluate, concentrated and desalted, and used in alkaline phosphatase induction experiments in place of dexamethasone.	Heparitin Sulfate	10-26	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	77-80
9061369-1	1997	Skin fibroblasts treated with brefeldin A produce a recycling variant of glypican (a glycosylphosphatidylinositolanchored heparan-sulfate proteoglycan) that is resistant to inositol-specific phospholipase C and incorporates sulfate and glucosamine into heparan sulfate chains (Fransson, L.-A.	Heparitin Sulfate	253-268	glypican 1	Homo sapiens	73-81
9061369-1	1997	Skin fibroblasts treated with brefeldin A produce a recycling variant of glypican (a glycosylphosphatidylinositolanchored heparan-sulfate proteoglycan) that is resistant to inositol-specific phospholipase C and incorporates sulfate and glucosamine into heparan sulfate chains (Fransson, L.-A.	Heparitin Sulfate	253-268	CD44 molecule (Indian blood group)	Homo sapiens	122-150
9089390-1	1997	Midkine (MK) is a 13-kDa heparin-binding growth/differentiation factor, and its interaction with heparan sulfate proteoglycan is important in promotion of neurite outgrowth.	Heparitin Sulfate	97-112	midkine	Rattus norvegicus	0-7
9089390-1	1997	Midkine (MK) is a 13-kDa heparin-binding growth/differentiation factor, and its interaction with heparan sulfate proteoglycan is important in promotion of neurite outgrowth.	Heparitin Sulfate	97-112	midkine	Rattus norvegicus	9-11
8996251-5	1997	We describe here that the antithrombotic effects of the ATPDase, like heparan sulfate and thrombomodulin, are lost after EC activation, both in vitro and in vivo.	Heparitin Sulfate	70-85	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	56-63
9381967-0	1997	Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations.	Heparitin Sulfate	141-156	brain derived neurotrophic factor	Homo sapiens	0-12
9381967-8	1997	Incubation of 70W cells with NGF or NT-3 but not brain-derived neurotrophic factor, neurotrophin-4/5 or mutant NGF resulted in increased release of heparanase activity that was capable of degrading a subpopulation of heparan sulfate molecules.	Heparitin Sulfate	217-232	nerve growth factor	Homo sapiens	29-32
9381967-8	1997	Incubation of 70W cells with NGF or NT-3 but not brain-derived neurotrophic factor, neurotrophin-4/5 or mutant NGF resulted in increased release of heparanase activity that was capable of degrading a subpopulation of heparan sulfate molecules.	Heparitin Sulfate	217-232	heparanase	Homo sapiens	148-158
9013976-6	1997	Binding of C1q to CSPG was competitively inhibited by free glycosaminoglycans (GAG) in the order dextran sulfate &gt; heparin &gt; heparan sulfate &gt; chondroitin-6-sulfate (CS-C) &gt; dermatan sulfate (CS-B) &gt; chondroitin-4-sulfate (CS-A).	Heparitin Sulfate	131-146	complement C1q A chain	Homo sapiens	11-14
8995662-8	1997	Our biosensor analyses showed that both heparan sulfate and dermatan sulfate inhibited gB2 binding (ED50 = 1 to 5 microg/ml), indicating that gB2 interacts with both heparin-like and dermatan sulfate glycosaminoglycans.	Heparitin Sulfate	40-55	gamma-aminobutyric acid type B receptor subunit 2	Homo sapiens	87-90
8995662-8	1997	Our biosensor analyses showed that both heparan sulfate and dermatan sulfate inhibited gB2 binding (ED50 = 1 to 5 microg/ml), indicating that gB2 interacts with both heparin-like and dermatan sulfate glycosaminoglycans.	Heparitin Sulfate	40-55	gamma-aminobutyric acid type B receptor subunit 2	Homo sapiens	142-145
8995662-10	1997	The affinity and specificity of gB2 binding to glycosaminoglycans demonstrated in these studies support its role in the initial binding of HSV-2 to cells bearing heparan sulfate or dermatan sulfate glycosaminoglycans.	Heparitin Sulfate	162-177	gamma-aminobutyric acid type B receptor subunit 2	Homo sapiens	32-35
9006931-3	1997	Transfection of human 293 cells resulted in the expression of N-syndecan that was modified by heparan sulfate chain addition.	Heparitin Sulfate	94-109	syndecan 3	Homo sapiens	62-72
9000592-1	1997	A number of growth factors, including members of the fibroblast growth factor (FGF) family - hepatocyte growth factor, vascular endothelial growth factor and heparin-binding epidermal growth factor - are dependent on heparan sulphate (HS) for biological activity mediated through their high-affinity signal-transducing receptors.	Heparitin Sulfate	217-233	fibroblast growth factor 2	Homo sapiens	79-82
9000592-1	1997	A number of growth factors, including members of the fibroblast growth factor (FGF) family - hepatocyte growth factor, vascular endothelial growth factor and heparin-binding epidermal growth factor - are dependent on heparan sulphate (HS) for biological activity mediated through their high-affinity signal-transducing receptors.	Heparitin Sulfate	235-237	fibroblast growth factor 2	Homo sapiens	79-82
9000592-6	1997	Here, we show that the mitogenic response to bFGF is dependent on the presence of heparan sulphate.	Heparitin Sulfate	82-98	fibroblast growth factor 2	Homo sapiens	45-49
9252193-5	1997	Of these, heparan sulphate, eluting as one well-defined peak (referred to as HS1) and another of lower activity and less well defined (HS2), was selected as the most likely to interact with growth factors and cytokines and was isolated from the eluate, concentrated and desalted, and used in alkaline phosphatase induction experiments in place of dexamethasone.	Heparitin Sulfate	10-26	spectrin beta, erythrocytic	Homo sapiens	135-138
9252193-8	1997	As the activity of HS1m could be abolished by heparinase and heparitinase but not by chondroitinase ABC, it was concluded that HS1m was a fraction of heparan sulphate involved in the regulation of paracrine growth factor activity in lung fibroblast-conditioned medium, and in the regulation of other growth factors with potential roles in the paracrine control of cell differentiation.	Heparitin Sulfate	150-166	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	19-22
9034166-4	1997	An increasing number of growth factors, including IGFs, FGFs, TGF-beta"s, and HGF, have been found to associate with the extracellular matrix proteins or with heparan sulfate.	Heparitin Sulfate	159-174	transforming growth factor beta 1	Homo sapiens	62-70
9034166-4	1997	An increasing number of growth factors, including IGFs, FGFs, TGF-beta"s, and HGF, have been found to associate with the extracellular matrix proteins or with heparan sulfate.	Heparitin Sulfate	159-174	hepatocyte growth factor	Homo sapiens	78-81
9386990-6	1997	First, we demonstrate that expression of KDR into a CHO cell line deficient in heparan sulfate biosynthesis does not allow VEGF165 binding unless heparin is exogenously added during the binding assay.	Heparitin Sulfate	79-94	vascular endothelial growth factor receptor 2	Cricetulus griseus	41-44
8973472-3	1996	The heparan sulfates from patients with Sanfilippo A (deficient in heparan N-sulfatase) and Sanfilippo B (deficient in alpha-N-acetylglucosaminidase) were degraded with heparitinase II producing, besides unsaturated disaccharides, substantial amounts of glucosamine N-sulfate and N-acetylglucosamine, respectively.	Heparitin Sulfate	4-20	N-acetyl-alpha-glucosaminidase	Homo sapiens	119-148
8997243-8	1996	Finally, HIP/PAP protein activity was tested and we showed that HIP/PAP induced the adhesion of rat hepatocytes and bound strongly to extracellular matrix proteins (laminin-1, fibronectin), less strongly to type I and IV collagen, and not at all to heparan sulfate proteoglycan.	Heparitin Sulfate	249-264	regenerating family member 3 beta	Rattus norvegicus	64-71
9485766-6	1996	Cellulose acetate membrane electrophoresis confirmed that both TC-I and TC-II contained only heparan sulfate as a sugar chain, and that the degree of sulfation of TC-I and TC-II was lower than that for normal tissue.	Heparitin Sulfate	93-108	transcobalamin 1	Homo sapiens	63-67
9485766-6	1996	Cellulose acetate membrane electrophoresis confirmed that both TC-I and TC-II contained only heparan sulfate as a sugar chain, and that the degree of sulfation of TC-I and TC-II was lower than that for normal tissue.	Heparitin Sulfate	93-108	transcobalamin 2	Homo sapiens	72-77
9485766-6	1996	Cellulose acetate membrane electrophoresis confirmed that both TC-I and TC-II contained only heparan sulfate as a sugar chain, and that the degree of sulfation of TC-I and TC-II was lower than that for normal tissue.	Heparitin Sulfate	93-108	transcobalamin 1	Homo sapiens	72-76
9485766-7	1996	Immunoblotting with monoclonal antibody HepSS-1 showed that TC-I and TC-II contained two heparan sulfate proteoglycans with Mr of about 30 kDa and 45 kDa, respectively.	Heparitin Sulfate	89-104	transcobalamin 1	Homo sapiens	60-64
9485766-7	1996	Immunoblotting with monoclonal antibody HepSS-1 showed that TC-I and TC-II contained two heparan sulfate proteoglycans with Mr of about 30 kDa and 45 kDa, respectively.	Heparitin Sulfate	89-104	transcobalamin 2	Homo sapiens	69-74
8971766-0	1997	Heparan sulfate potentiates the autocrine action of basic fibroblast growth factor in astrocytes: an in vivo and in vitro study.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Rattus norvegicus	52-82
8971766-2	1997	In this study we examined the possibility that heparan sulfate can modulate the basic fibroblast growth factor system at a more fundamental level than activity regulation, by influencing the synthesis of basic fibroblast growth factor and its receptor messenger RNAs.	Heparitin Sulfate	47-62	fibroblast growth factor 2	Rattus norvegicus	80-110
8971766-2	1997	In this study we examined the possibility that heparan sulfate can modulate the basic fibroblast growth factor system at a more fundamental level than activity regulation, by influencing the synthesis of basic fibroblast growth factor and its receptor messenger RNAs.	Heparitin Sulfate	47-62	fibroblast growth factor 2	Rattus norvegicus	204-234
8971766-4	1997	Accordingly, we examined the possibility that the action of heparan sulfate on the basic fibroblast growth factor system could have a critical role in the modulation of reactivity and/or proliferation of astrocytes in vitro and in vivo.	Heparitin Sulfate	60-75	fibroblast growth factor 2	Rattus norvegicus	83-113
8971766-7	1997	All of these actions, both in vitro and in vivo, were highly potentiated when heparan sulfate was applied in combination with basic fibroblast growth factor.	Heparitin Sulfate	78-93	fibroblast growth factor 2	Rattus norvegicus	126-156
8971766-8	1997	These results suggest that basic fibroblast growth factor regulates astrocytic proliferation or reactivity via an autocrine cascade that involves induction of its own receptor and that this action is modulated by heparan sulfate.	Heparitin Sulfate	213-228	fibroblast growth factor 2	Rattus norvegicus	27-57
8958336-1	1996	Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked overgrowth disorder recently shown to be caused by mutations in the heparan sulfate proteoglycan GPC3 [Pilia et al., Nat Genet; 12:241-247 1996].	Heparitin Sulfate	121-136	glypican 3	Homo sapiens	32-36
8958336-1	1996	Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked overgrowth disorder recently shown to be caused by mutations in the heparan sulfate proteoglycan GPC3 [Pilia et al., Nat Genet; 12:241-247 1996].	Heparitin Sulfate	121-136	glypican 3	Homo sapiens	150-154
8939951-2	1996	In order to determine whether association of sPLA2 with cell surfaces via heparan sulfate proteoglycan is important for its effects on cellular functions, we have identified the critical domain in sPLA2 for heparin and cell surface binding and examined its role in cellular prostaglandin (PG) biosynthesis.	Heparitin Sulfate	74-89	phospholipase A2 group IIA	Rattus norvegicus	45-50
8920859-2	1996	Here we show that the CS protein interacts not only with cell surface heparan sulfate, but also with the low density lipoprotein receptor-related protein (LRP).	Heparitin Sulfate	70-85	low density lipoprotein receptor-related protein 1	Mus musculus	155-158
8890228-10	1996	The anti-mouse L-selectin staining of miracidia could be inhibited by wash buffer containing sulfated carbohydrates such as sulfated Le(x), heparan sulfate, fucoidan, and carrageenan.	Heparitin Sulfate	140-155	selectin, lymphocyte	Mus musculus	15-25
8920859-4	1996	Blockage of LRP by RAP or anti-LRP antibodies on heparan sulfate-deficient CHO cells results in more than 90% inhibition of binding and endocytosis of recombinant CS protein.	Heparitin Sulfate	49-64	low density lipoprotein receptor-related protein 1	Mus musculus	12-15
8920859-4	1996	Blockage of LRP by RAP or anti-LRP antibodies on heparan sulfate-deficient CHO cells results in more than 90% inhibition of binding and endocytosis of recombinant CS protein.	Heparitin Sulfate	49-64	LDL receptor related protein associated protein 1	Homo sapiens	19-22
8920859-4	1996	Blockage of LRP by RAP or anti-LRP antibodies on heparan sulfate-deficient CHO cells results in more than 90% inhibition of binding and endocytosis of recombinant CS protein.	Heparitin Sulfate	49-64	low density lipoprotein receptor-related protein 1	Mus musculus	31-34
8920859-6	1996	Heparinase-pretreatment of LRP-deficient fibroblasts or blockage of LRP on heparan sulfate-deficient CHO cells by RAP, lactoferrin, or anti-LRP antibodies reduces Plasmodium berghei invasion by 60-70%.	Heparitin Sulfate	75-90	low density lipoprotein receptor-related protein 1	Mus musculus	68-71
8920859-6	1996	Heparinase-pretreatment of LRP-deficient fibroblasts or blockage of LRP on heparan sulfate-deficient CHO cells by RAP, lactoferrin, or anti-LRP antibodies reduces Plasmodium berghei invasion by 60-70%.	Heparitin Sulfate	75-90	LDL receptor related protein associated protein 1	Homo sapiens	114-117
8920859-6	1996	Heparinase-pretreatment of LRP-deficient fibroblasts or blockage of LRP on heparan sulfate-deficient CHO cells by RAP, lactoferrin, or anti-LRP antibodies reduces Plasmodium berghei invasion by 60-70%.	Heparitin Sulfate	75-90	low density lipoprotein receptor-related protein 1	Mus musculus	68-71
8849730-5	1996	Here we show that non-phosphorylated recombinant tau isoforms with three microtubule-binding repeats form paired helical-like filaments under physiological conditions in vitro, when incubated with sulphated glycosaminoglycans such as heparin or heparan sulphate.	Heparitin Sulfate	245-261	microtubule associated protein tau	Homo sapiens	49-52
8828497-4	1996	Previous studies showed that heparin inhibited IGFBP-3 binding to the cell surface and increased its accumulation in the medium, suggesting that it might act as a competitive inhibitor of IGFBP-3 binding to structurally similar heparan sulfate proteoglycans on the cell surface.	Heparitin Sulfate	228-243	insulin like growth factor binding protein 3	Homo sapiens	47-54
8900197-1	1996	LTA cells synthesize a minor population of heparan sulfate proteoglycans (HSPGact) bearing anticoagulant heparan sulfate (HSact) with a specific monosaccharide sequence that accelerates the action of antithrombin (AT).	Heparitin Sulfate	43-58	serpin family C member 1	Homo sapiens	200-212
8873769-12	1996	This interaction occurs at the epithelial-mesenchymal interface and is mediated by a site in the LM molecule represented by peptide F-9 and the heparan sulfate groups of HSPG.	Heparitin Sulfate	144-159	syndecan 2	Mus musculus	170-174
8824283-6	1996	A gel mobility shift assay showed that the affinity of phospholipase A2 for glycosaminoglycans from a heparan sulfate/chondroitin sulfate proteoglycan was higher than for chondroitin sulfate glycosaminoglycans from a larger versican-like proteoglycan.	Heparitin Sulfate	102-117	phospholipase A2 group IB	Homo sapiens	55-71
8843859-6	1996	FN fragments containing Hep2 or heparan sulfate inhibited the adhesion of SC onto EDA+ FN.	Heparitin Sulfate	32-47	ectodysplasin A	Homo sapiens	82-85
8808643-1	1996	Heparin and heparan sulfate are related glycosaminoglycans which demonstrate high-affinity interactions with a number of proteins, including antithrombin III.	Heparitin Sulfate	12-27	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	141-157
8906423-8	1996	The CD44 (V3-V10) isoform found in the ridge is expressed elsewhere as a proteoglycan with heparan sulfate chains that bind fibroblast growth factors.	Heparitin Sulfate	91-106	CD44 antigen	Mus musculus	4-8
8933277-4	1996	The T cell clones from BWF1 mice but not those from BALB/c mice proliferated against heparan sulfate, the major glycosaminoglycan of glomerular basement membrane.	Heparitin Sulfate	85-100	WD repeat and FYVE domain containing 3	Mus musculus	23-27
8933277-7	1996	When cultured with either heparan sulfate or Concanavalin A, the T cell clones produced high levels of IL-4 and IL-5 with no detectable IL-2 or IFN-gamma.	Heparitin Sulfate	26-41	interleukin 4	Mus musculus	103-107
8933277-7	1996	When cultured with either heparan sulfate or Concanavalin A, the T cell clones produced high levels of IL-4 and IL-5 with no detectable IL-2 or IFN-gamma.	Heparitin Sulfate	26-41	interleukin 5	Mus musculus	112-116
8933277-9	1996	These studies indicate the existence of heparan sulfate-reactive T cells in BWF1 mice.	Heparitin Sulfate	40-55	WD repeat and FYVE domain containing 3	Mus musculus	76-80
8828497-4	1996	Previous studies showed that heparin inhibited IGFBP-3 binding to the cell surface and increased its accumulation in the medium, suggesting that it might act as a competitive inhibitor of IGFBP-3 binding to structurally similar heparan sulfate proteoglycans on the cell surface.	Heparitin Sulfate	228-243	insulin like growth factor binding protein 3	Homo sapiens	188-195
8855323-5	1996	Heparan sulfate markedly reduced binding of the MBP-MOMP to cells, whereas chondroitin sulfate had no effect on binding.	Heparitin Sulfate	0-15	myelin basic protein	Homo sapiens	48-51
8855323-8	1996	Mutant cell lines defective in heparan sulfate synthesis but not chondroitin sulfate synthesis showed a marked reduction in the binding of MBP-MOMP and were also less susceptible to infection by chlamydiae.	Heparitin Sulfate	31-46	myelin basic protein	Homo sapiens	139-142
8810923-0	1996	Interaction of lipoprotein lipase with heparin fragments and with heparan sulfate: stoichiometry, stabilization, and kinetics.	Heparitin Sulfate	66-81	lipoprotein lipase	Homo sapiens	15-33
8810923-1	1996	The interaction of lipoprotein lipase (LPL) with heparan sulfate and with size-fractionated fragments of heparin was characterized by several approaches (stabilization, sedimentation, surface plasmon resonance, circular dichroism, fluorescence).	Heparitin Sulfate	49-64	lipoprotein lipase	Homo sapiens	19-37
8810923-1	1996	The interaction of lipoprotein lipase (LPL) with heparan sulfate and with size-fractionated fragments of heparin was characterized by several approaches (stabilization, sedimentation, surface plasmon resonance, circular dichroism, fluorescence).	Heparitin Sulfate	49-64	lipoprotein lipase	Homo sapiens	39-42
8810923-5	1996	Interaction of LPL with heparan sulfate, as studied by surface plasmon resonance, was found to be a fast exchange process characterized by a high value for the association rate constant, 1.7 x 10(8) M-1 s-1, a relatively high dissociation rate constant, 0.05 s-1, and as a result a very low equilibrium dissociation constant equal to 0.3 nM at 0.15 M NaCl.	Heparitin Sulfate	24-39	lipoprotein lipase	Homo sapiens	15-18
8810923-6	1996	The contribution of electrostatics was estimated to be 44% for the binding of LPL to heparan sulfate, 49% for the binding of LPL to unfractionated heparin, and 60% for the binding of LPL to affinity-purified heparin decasaccharides at 0.15 M NaCl.	Heparitin Sulfate	85-100	lipoprotein lipase	Homo sapiens	78-81
8810923-10	1996	A model for binding of LPL to heparan sulfate-covered surfaces is proposed.	Heparitin Sulfate	30-45	lipoprotein lipase	Homo sapiens	23-26
8810923-11	1996	Due to the fast rebinding, LPL is concentrated to the close proximity of the heparan sulfate surface.	Heparitin Sulfate	77-92	lipoprotein lipase	Homo sapiens	27-30
8780517-3	1996	Several models propose an important role for heparan sulfate not only in facilitating FGF-2 binding to its receptor tyrosine kinase but also in promoting signaling via formation of receptor dimers.	Heparitin Sulfate	45-60	fibroblast growth factor 2	Mus musculus	86-91
8905627-5	1996	The three putative sites containing the consensus sequence SGD for attachment of heparan sulfate chains were fully conserved in the rat perlecan as was a site (NFT) for attachment of N-linked oligosaccharide.	Heparitin Sulfate	81-96	heparan sulfate proteoglycan 2	Rattus norvegicus	136-144
8792767-7	1996	Pretreatment of monolayers with heparitinase I (and of extracellular matrix with HNO2) to degrade heparan sulfate blocked the thrombin-HCII inhibition rate increase.	Heparitin Sulfate	98-113	coagulation factor II, thrombin	Homo sapiens	126-134
8792767-7	1996	Pretreatment of monolayers with heparitinase I (and of extracellular matrix with HNO2) to degrade heparan sulfate blocked the thrombin-HCII inhibition rate increase.	Heparitin Sulfate	98-113	serpin family D member 1	Homo sapiens	135-139
8816920-1	1996	The interaction of basic FGF (bFGF) with heparin, heparan sulfate and related sugars can potentiate or antagonize bFGF activity, depending on the size of the saccharide used.	Heparitin Sulfate	50-65	fibroblast growth factor 2	Homo sapiens	19-28
8816920-1	1996	The interaction of basic FGF (bFGF) with heparin, heparan sulfate and related sugars can potentiate or antagonize bFGF activity, depending on the size of the saccharide used.	Heparitin Sulfate	50-65	fibroblast growth factor 2	Homo sapiens	30-34
8816920-1	1996	The interaction of basic FGF (bFGF) with heparin, heparan sulfate and related sugars can potentiate or antagonize bFGF activity, depending on the size of the saccharide used.	Heparitin Sulfate	50-65	fibroblast growth factor 2	Homo sapiens	114-118
8816920-6	1996	We report that the ability of sulfated malto-oligosaccharides to block binding of bFGF to heparan sulfate was dependent on the size (at least a tetrasaccharide is required), and the degree of sulfation.	Heparitin Sulfate	90-105	fibroblast growth factor 2	Homo sapiens	82-86
9552515-2	1996	These features include the fact that VEGF is naturally secreted, binds to cell-surface heparan sulfates, is generated by hypoxic endothelial cells, reduces apoptosis, and binds to high-affinity receptors that are upregulated by hypoxia.	Heparitin Sulfate	87-103	vascular endothelial growth factor A	Homo sapiens	37-41
8836130-0	1996	Interferon gamma differentially affects the synthesis of chondroitin/dermatan sulphate and heparan sulphate by human skin fibroblasts.	Heparitin Sulfate	91-107	interferon gamma	Homo sapiens	0-16
8780385-8	1996	Based on binding competition assays, TSP-1 exhibited higher affinity for SF than did nine other ECM molecules, including Fn and heparan sulfate proteoglycan.	Heparitin Sulfate	128-143	thrombospondin 1	Homo sapiens	37-42
8781318-7	1996	Cultured HSC showed a membranous staining pattern for syndecan-1, syndecan-3, and heparan sulfate, and in addition intracellular staining for syndecan-2, -3, and 4.	Heparitin Sulfate	82-97	fucosyltransferase 1 (H blood group)	Homo sapiens	9-12
8780517-6	1996	As shown previously, fibroblasts treated with chlorate, which inhibits the sulfation of heparan sulfate and its subsequent binding to FGF-2, display a dramatically reduced response to picomolar concentrations of FGF-2, but binding to receptors and a mitogenic response is restored by heparin.	Heparitin Sulfate	88-103	fibroblast growth factor 2	Mus musculus	134-139
8780517-6	1996	As shown previously, fibroblasts treated with chlorate, which inhibits the sulfation of heparan sulfate and its subsequent binding to FGF-2, display a dramatically reduced response to picomolar concentrations of FGF-2, but binding to receptors and a mitogenic response is restored by heparin.	Heparitin Sulfate	88-103	fibroblast growth factor 2	Mus musculus	212-217
8780517-13	1996	In one, heparan sulfate participates in FGF-2 binding to its receptor tyrosine kinase and activation of mitogenic signaling, perhaps through monomeric receptors or the transient formation of receptor dimers.	Heparitin Sulfate	8-23	fibroblast growth factor 2	Mus musculus	40-45
8760376-0	1996	Structural domains of heparan sulphate for specific recognition of the C-terminal heparin-binding domain of human plasma fibronectin (HEPII).	Heparitin Sulfate	22-38	fibronectin 1	Homo sapiens	121-132
8946167-1	1996	Sanfilippo A syndrome (MPS-IIIA) is a mucopolysaccharide lysosomal storage disorder caused by a deficiency in the lysosomal enzyme, sulphamidase (EC 3.10.1.1), which is required for the degradation of heparan sulphate.	Heparitin Sulfate	201-217	N-sulfoglucosamine sulfohydrolase	Homo sapiens	132-144
8706341-0	1996	Elastase, but not proteinase 3 (PR3), induces proteinuria associated with loss of glomerular basement membrane heparan sulphate after in vivo renal perfusion in rats.	Heparitin Sulfate	111-127	proteinase 3	Rattus norvegicus	0-8
8706341-1	1996	Elastase, but not PR3, induces proteinuria associated with loss of glomerular basement membrane (GBM) heparan sulphate after in vivo renal perfusion in rats.	Heparitin Sulfate	102-118	proteinase 3	Rattus norvegicus	0-8
8706341-8	1996	However, immunohistology revealed that proteinuria occurring after perfusion of active elastase was associated with a strong reduction in intraglomerular expression of the heparan sulphate side chain and, to a lesser extent, of the protein core of heparan sulphate proteoglycans (HSPG).	Heparitin Sulfate	172-188	proteinase 3	Rattus norvegicus	87-95
8662884-2	1996	The protein, p200, which has an apparent molecular mass of approximately 200 kDa, was identified by its ability to bind the cell surface heparan sulfate proteoglycan N-syndecan (syndecan-3) in a membrane overlay assay.	Heparitin Sulfate	137-152	syndecan 3	Rattus norvegicus	166-176
8663244-8	1996	Degradation of TSP2 was slower in cultures of Chinese hamster ovary (CHO) cells lacking heparan sulfate proteoglycans than in wild type CHO cells or in cultures of 3T3 cells treated with heparitinase than in untreated 3T3 cells.	Heparitin Sulfate	88-103	tumor suppressor region 2	Mus musculus	15-19
8663244-10	1996	This study indicates that TSP2 and TSP1 are metabolized by a common internalization and degradation pathway involving heparan sulfate proteoglycan and LRP.	Heparitin Sulfate	118-133	tumor suppressor region 2	Mus musculus	26-30
8663244-10	1996	This study indicates that TSP2 and TSP1 are metabolized by a common internalization and degradation pathway involving heparan sulfate proteoglycan and LRP.	Heparitin Sulfate	118-133	tumor suppressor region 1	Mus musculus	35-39
8829116-4	1996	ELISA measurements with a heparan sulfate (HS)-specific monoclonal antibody confirmed that AngII decreased HS production.	Heparitin Sulfate	26-41	angiotensinogen	Homo sapiens	91-96
8829116-4	1996	ELISA measurements with a heparan sulfate (HS)-specific monoclonal antibody confirmed that AngII decreased HS production.	Heparitin Sulfate	43-45	angiotensinogen	Homo sapiens	91-96
8829116-9	1996	These results indicate that the decrease in HS synthesis induced by AngII is not mediated by an increase in TGF-beta, but on the contrary, the increase in TGF-beta partially counteracts the inhibition of HS production by AngII.	Heparitin Sulfate	44-46	angiotensinogen	Homo sapiens	68-73
8663206-1	1996	Interferon-gamma (IFN-gamma) binds with high affinity to heparan sulfate and heparin molecules through its carboxyl-terminal domain.	Heparitin Sulfate	57-72	interferon gamma	Homo sapiens	0-16
8663206-1	1996	Interferon-gamma (IFN-gamma) binds with high affinity to heparan sulfate and heparin molecules through its carboxyl-terminal domain.	Heparitin Sulfate	57-72	interferon gamma	Homo sapiens	18-27
8663206-2	1996	In vivo, IFN-gamma is eliminated from the bloodstream with a half-life (t1/2) of 1.1 min, due to binding to heparan sulfate.	Heparitin Sulfate	108-123	interferon gamma	Homo sapiens	9-18
8663206-2	1996	In vivo, IFN-gamma is eliminated from the bloodstream with a half-life (t1/2) of 1.1 min, due to binding to heparan sulfate.	Heparitin Sulfate	108-123	CD6 molecule	Homo sapiens	72-84
8663206-7	1996	These data demonstrate that the blood clearance of the cytokine is a non-receptor-mediated process and that in vivo the local concentration of heparan sulfate/heparin-like molecules regulates IFN-gamma activity by a unique mechanism involving a controlled processing of its carboxyl-terminal sequence.	Heparitin Sulfate	143-158	interferon gamma	Homo sapiens	192-201
8891437-1	1996	In addition to its cellular receptor, interferon-gamma (IFN-gamma) displays a high affinity for heparan sulfate.	Heparitin Sulfate	96-111	interferon gamma	Homo sapiens	38-54
8891437-1	1996	In addition to its cellular receptor, interferon-gamma (IFN-gamma) displays a high affinity for heparan sulfate.	Heparitin Sulfate	96-111	interferon gamma	Homo sapiens	56-65
8891437-3	1996	For this purpose, rats were injected with [125I]-labelled human IFN-gamma, which does not bind to murine IFN-gamma receptors, but binds to murine heparan sulfate.	Heparitin Sulfate	146-161	interferon gamma	Homo sapiens	64-73
8891437-5	1996	Furthermore, [125I]-IFN-gamma was detected by autoradiographic analysis only in restricted areas within tissues, which correlates with the known locations of heparan sulfate.	Heparitin Sulfate	158-173	interferon gamma	Homo sapiens	20-29
8891437-7	1996	Heparin bound to [125I]-IFN-gamma was also used to block the heparan sulfate binding site of the cytokine.	Heparitin Sulfate	61-76	interferon gamma	Homo sapiens	24-33
8891437-10	1996	Taken together, these data demonstrate that heparan sulfate molecules are involved in blood clearance and in the subsequent tissue targeting, accumulation, and localization of [125I]-IFN-gamma.	Heparitin Sulfate	44-59	interferon gamma	Homo sapiens	183-192
8840224-4	1996	Soluble heparin and heparan sulfate inhibited both C3a and TCC formation, but surface-conjugated heparin had only a minor effect.	Heparitin Sulfate	20-35	complement C3	Homo sapiens	51-54
8663298-8	1996	Examination of several well characterized glycosaminoglycans to inhibit the binding of heparin to both heparin-binding IGFBP-3 peptides revealed that the most potent inhibitors were heparin, heparan sulfate, and dermatan sulfate; chondroitin sulfate A and hyaluronic acid were intermediate in their inhibitory activities; and chondroitin sulfate C caused no inhibition.	Heparitin Sulfate	191-206	insulin like growth factor binding protein 3	Homo sapiens	119-126
8665526-0	1996	Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations.	Heparitin Sulfate	141-156	brain derived neurotrophic factor	Homo sapiens	0-12
8665526-9	1996	Incubation of 70W cells with NGF or NT-3, but not brain-derived NT factor, NT-4/5, or mutant NGF, resulted in increased release of heparanase activity that was capable of degrading a subpopulation of heparan sulfate molecules.	Heparitin Sulfate	200-215	nerve growth factor	Homo sapiens	29-32
8643556-2	1996	While EC-SOD from most mammals is tetrameric and has a high affinity for heparin and heparan sulfate, rat EC-SOD has a low affinity for heparin, does not bind to heparan sulfate in vivo, and is apparently dimeric.	Heparitin Sulfate	85-100	superoxide dismutase 3	Rattus norvegicus	6-12
8674415-6	1996	In whole lung explants, branching morphogenesis was inhibited by antibodies against the AR heparan sulfate binding site and stimulated by exogenous AR.	Heparitin Sulfate	91-106	amphiregulin	Mus musculus	88-90
8682650-6	1996	Assuming that a) heparinase treatment abolished the heparan-sulfate pathway, and that b) the degradation remaining in heparin-treated cultures represents nonspecific values, it appears that heparan sulfate contributes about 61%, 83% and 95% of total LPL degradation, whereas the LRP pathway contributes 39%, 17% and less than 5% of LPL degradation in MEF, PEA-10 and PEA-13 cells, respectively.	Heparitin Sulfate	190-205	lipoprotein lipase	Mus musculus	250-253
8682650-6	1996	Assuming that a) heparinase treatment abolished the heparan-sulfate pathway, and that b) the degradation remaining in heparin-treated cultures represents nonspecific values, it appears that heparan sulfate contributes about 61%, 83% and 95% of total LPL degradation, whereas the LRP pathway contributes 39%, 17% and less than 5% of LPL degradation in MEF, PEA-10 and PEA-13 cells, respectively.	Heparitin Sulfate	190-205	low density lipoprotein receptor-related protein 1	Mus musculus	279-282
8682650-6	1996	Assuming that a) heparinase treatment abolished the heparan-sulfate pathway, and that b) the degradation remaining in heparin-treated cultures represents nonspecific values, it appears that heparan sulfate contributes about 61%, 83% and 95% of total LPL degradation, whereas the LRP pathway contributes 39%, 17% and less than 5% of LPL degradation in MEF, PEA-10 and PEA-13 cells, respectively.	Heparitin Sulfate	190-205	lipoprotein lipase	Mus musculus	332-335
8682650-7	1996	In addition, the data indicate that LPL interaction with heparan sulfate and the LRP pathways is independent of each other.	Heparitin Sulfate	57-72	lipoprotein lipase	Mus musculus	36-39
8667612-1	1996	In experimental murine inflammation-associated amyloidosis (AA amyloidosis), an interaction between heparan sulfate and serum amyloid A (SAA), the AA precursor, has been demonstrated and is believed to play an important role in AA amyloidogenesis.	Heparitin Sulfate	100-115	serum amyloid A cluster	Mus musculus	120-135
8667612-1	1996	In experimental murine inflammation-associated amyloidosis (AA amyloidosis), an interaction between heparan sulfate and serum amyloid A (SAA), the AA precursor, has been demonstrated and is believed to play an important role in AA amyloidogenesis.	Heparitin Sulfate	100-115	serum amyloid A cluster	Mus musculus	137-140
8674529-0	1996	Interferon-gamma inhibits 35S incorporation in heparan sulfate synthesized by human skin fibroblasts.	Heparitin Sulfate	47-62	interferon gamma	Homo sapiens	0-16
8674529-5	1996	These data demonstrate that IFNgamma inhibits the incorporation of sulfate from extracellular medium into heparan sulfate.	Heparitin Sulfate	106-121	interferon gamma	Homo sapiens	28-36
8842489-7	1996	In the present review we focus on the involvement of HS in basic FGF (bFGF) receptor binding and mitogenic activity and its modulation by species of heparin, HS, and synthetic polyanionic "heparin-mimicking" compounds.	Heparitin Sulfate	53-55	fibroblast growth factor 2	Homo sapiens	59-68
8842489-7	1996	In the present review we focus on the involvement of HS in basic FGF (bFGF) receptor binding and mitogenic activity and its modulation by species of heparin, HS, and synthetic polyanionic "heparin-mimicking" compounds.	Heparitin Sulfate	53-55	fibroblast growth factor 2	Homo sapiens	70-74
8776591-1	1996	Sanfilippo B syndrome is caused by a deficiency of alpha-N-acetylglucosaminidase, a lysosomal enzyme involved in the degradation of heparan sulphate.	Heparitin Sulfate	132-148	N-acetyl-alpha-glucosaminidase	Homo sapiens	51-80
8682648-0	1996	Synthesis and secretion of lipoprotein lipase in heparan sulfate-deficient Chinese hamster ovary cells.	Heparitin Sulfate	49-64	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	27-45
8682648-10	1996	These results suggest that if lipoprotein lipase needs a carrier during intracellular assembly and transport, this function can be fulfilled by some structure other than heparan sulfate.	Heparitin Sulfate	170-185	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	30-48
8682650-0	1996	Heparan sulfate-dependent and low density lipoprotein receptor-related protein-dependent catabolic pathways for lipoprotein lipase in mouse embryonic fibroblasts.	Heparitin Sulfate	0-15	lipoprotein lipase	Mus musculus	112-130
8682650-1	1996	Heparan sulfate and low density lipoprotein receptor related protein (LRP) have been shown to participate in the uptake and degradation of the enzyme lipoprotein lipase (LPL).	Heparitin Sulfate	0-15	low density lipoprotein receptor-related protein 1	Mus musculus	70-73
8682650-1	1996	Heparan sulfate and low density lipoprotein receptor related protein (LRP) have been shown to participate in the uptake and degradation of the enzyme lipoprotein lipase (LPL).	Heparitin Sulfate	0-15	lipoprotein lipase	Mus musculus	150-168
8682650-1	1996	Heparan sulfate and low density lipoprotein receptor related protein (LRP) have been shown to participate in the uptake and degradation of the enzyme lipoprotein lipase (LPL).	Heparitin Sulfate	0-15	lipoprotein lipase	Mus musculus	170-173
8732706-1	1996	OBJECTIVE: Tissue factor pathway inhibitor (TFPI) is bound to vascular endothelium (presumably to heparan sulfate) and circulates in complex with plasma lipoproteins.	Heparitin Sulfate	98-113	tissue factor pathway inhibitor	Homo sapiens	11-42
8645178-1	1996	We previously reported that a mouse Lewis lung carcinoma-derived stroma-inducing clone, P29, highly expresses a syndecan-like proteoglycan exhibiting specific binding to fibronectin, a major constituent of the interstitial matrix formed by the induced stromal cells, via its heparan sulphate chains [Itano, Oguri, Nakanishi and Okayama (1993) J. Biochem.	Heparitin Sulfate	275-291	SYF2 homolog, RNA splicing factor (S. cerevisiae)	Mus musculus	88-91
8645178-1	1996	We previously reported that a mouse Lewis lung carcinoma-derived stroma-inducing clone, P29, highly expresses a syndecan-like proteoglycan exhibiting specific binding to fibronectin, a major constituent of the interstitial matrix formed by the induced stromal cells, via its heparan sulphate chains [Itano, Oguri, Nakanishi and Okayama (1993) J. Biochem.	Heparitin Sulfate	275-291	fibronectin 1	Mus musculus	170-181
8732706-1	1996	OBJECTIVE: Tissue factor pathway inhibitor (TFPI) is bound to vascular endothelium (presumably to heparan sulfate) and circulates in complex with plasma lipoproteins.	Heparitin Sulfate	98-113	tissue factor pathway inhibitor	Homo sapiens	44-48
8613703-11	1996	Competition experiments showed that serglycin was as efficient as heparin sulfate in blocking the binding of [3H] chondrotin sulfate to PF4, whereas heparin was one order of magnitude more efficient.	Heparitin Sulfate	66-81	platelet factor 4	Homo sapiens	136-139
8611511-0	1996	Expression of the mouse mastocytoma glucosaminyl N-deacetylase/ N-sulfotransferase in human kidney 293 cells results in increased N-sulfation of heparan sulfate.	Heparitin Sulfate	145-160	sulfotransferase family 1D, member 1	Mus musculus	64-82
8668693-2	1996	Mucin is a gelatinous substance composed of glycosaminoglycanes, especially hyaluronic acid and dermatan sulfate bound to small quantities of chondoitin sulfate and heparin sulfate.	Heparitin Sulfate	165-180	LOC100508689	Homo sapiens	0-5
8609172-1	1996	The formation of distinctive basic FGF-heparan sulfate complexes is essential for the binding of bFGF to its cognate receptor.	Heparitin Sulfate	39-54	fibroblast growth factor 2	Homo sapiens	35-38
8609172-1	1996	The formation of distinctive basic FGF-heparan sulfate complexes is essential for the binding of bFGF to its cognate receptor.	Heparitin Sulfate	39-54	fibroblast growth factor 2	Homo sapiens	97-101
8626565-7	1996	We showed also that perlecan bound bFGF specifically by the heparan sulfate chains located on the amino-terminal domain I.	Heparitin Sulfate	60-75	fibroblast growth factor 2	Homo sapiens	35-39
8626565-10	1996	Our findings provide direct evidence that bFGF binds to heparan sulfate sequences attached to domain I and support the hypothesis that perlecan represents a major storage site for this growth factor in the blood vessel wall.	Heparitin Sulfate	56-71	fibroblast growth factor 2	Homo sapiens	42-46
8626565-11	1996	Moreover, the concerted action of proteases that degrade the protein core and heparanases that remove the heparan sulfate may modulate the bioavailability of the growth factor.	Heparitin Sulfate	106-121	myotrophin	Rattus norvegicus	162-175
8807193-5	1996	Our experiments support the view that NCAM can interact with multiple, but not with all, heparan sulfate and chondroitin sulfate proteoglycans in chick brain membranes in both positive and negative ways to influence cell adhesion.	Heparitin Sulfate	89-104	neural cell adhesion molecule 1	Gallus gallus	38-42
8642635-9	1996	Binding of PrV to this HSPG in the VOPBA was also dependent on the presence of heparan sulfate, since reactivity was abolished after suppression of glycosaminoglycan biosynthesis with NaClO3 and after heparinase treatment.	Heparitin Sulfate	79-94	syndecan 2	Homo sapiens	23-27
8656041-2	1996	In this article we demonstrate that the binding of PF4 on HEL cells and its inhibitory effect on HEL cell growth were mediated by heparan sulfate.	Heparitin Sulfate	130-145	platelet factor 4	Homo sapiens	51-54
8656041-3	1996	We found that binding of iodine 125-labeled PF4 to HEL cells was inhibited by heparin, heparan sulfate, and dermatan sulfate and to a smaller extent by chondroitin sulfate.	Heparitin Sulfate	87-102	platelet factor 4	Homo sapiens	44-47
8656041-4	1996	Ninety percent of 125I-labeled PF4 bound to HEL cells was released by cells after exposure to heparin and heparan sulfate.	Heparitin Sulfate	106-121	platelet factor 4	Homo sapiens	31-34
8732775-0	1996	Lipoprotein lipase-enhanced binding of human triglyceride-rich lipoproteins to heparan sulfate: modulation by apolipoprotein E and apolipoprotein C. The objective of this study was to investigate whether compositional variation in apolipoprotein (apo) content of triglyceride-rich lipoproteins (TRLP) modulates binding of heparan sulfate proteoglycans (HSPG).	Heparitin Sulfate	79-94	lipoprotein lipase	Homo sapiens	0-18
8838814-1	1996	Heparan sulfate-N-deacetylase/N-sulfotransferase (HSST) catalyzes both the N-deacetylation and the N-sulfation of heparan sulfate.	Heparitin Sulfate	114-129	N-deacetylase and N-sulfotransferase 1	Homo sapiens	0-48
8783184-3	1996	Heparin, and, to a lesser extent, heparan sulfate induced release of a 58-kDa, gelatin-degrading enzyme which was subsequently identified as the collagenase, matrix metalloproteinase-1.	Heparitin Sulfate	34-49	matrix metallopeptidase 1	Homo sapiens	158-184
8838814-1	1996	Heparan sulfate-N-deacetylase/N-sulfotransferase (HSST) catalyzes both the N-deacetylation and the N-sulfation of heparan sulfate.	Heparitin Sulfate	114-129	N-deacetylase and N-sulfotransferase 1	Homo sapiens	50-54
8621410-11	1996	Heparin or cell surface heparan sulfates restored the flk-1 binding ability of damaged VEGF165 but not the receptor binding ability of damaged VEGF121.	Heparitin Sulfate	24-40	kinase insert domain receptor	Homo sapiens	54-59
8617759-1	1996	The growth promoting activity of the subendothelial extracellular matrix (ECM) is attributed to sequestration of basic fibroblast growth factor (bFGF) by heparan sulfate proteoglycans and its regulated release by heparin-like molecules and heparan sulfate (HS) degrading enzymes.	Heparitin Sulfate	240-255	fibroblast growth factor 2	Homo sapiens	145-149
8906988-3	1996	It appears that sCD4 can induce the binding of HIV-1IIIB to CD4-negative human cells and to H9 cells with downregulated expression of CD4 at both 4 and 37 degrees C. The binding is proportional to the amount of sCD4 associated with virions, and requires the presence of heparan sulfate proteoglycans on the surface of cells.	Heparitin Sulfate	270-285	CD4 molecule	Homo sapiens	17-20
8616530-8	1996	Growth hormone stimulation (5.0 and 10.0 ng/ml) caused a significant decrease in the ratio between heparan sulphate proteoglycan and proteoglycan in the cell layer (2p &lt; 0.02 and 2p &lt; 0.01), whereas the distribution of proteoglycans between the cell layer and the medium was unaltered.	Heparitin Sulfate	99-115	growth hormone 1	Homo sapiens	0-14
8617759-1	1996	The growth promoting activity of the subendothelial extracellular matrix (ECM) is attributed to sequestration of basic fibroblast growth factor (bFGF) by heparan sulfate proteoglycans and its regulated release by heparin-like molecules and heparan sulfate (HS) degrading enzymes.	Heparitin Sulfate	154-169	fibroblast growth factor 2	Homo sapiens	113-143
8601596-4	1996	High expressing transfectants (Raji-Sl cells) bind to and spread on immobilized thrombospondin or fibronectin, which are ligands for the heparan sulfate chains of the proteoglycan.	Heparitin Sulfate	137-152	fibronectin 1	Homo sapiens	98-109
8617759-1	1996	The growth promoting activity of the subendothelial extracellular matrix (ECM) is attributed to sequestration of basic fibroblast growth factor (bFGF) by heparan sulfate proteoglycans and its regulated release by heparin-like molecules and heparan sulfate (HS) degrading enzymes.	Heparitin Sulfate	154-169	fibroblast growth factor 2	Homo sapiens	145-149
8617759-1	1996	The growth promoting activity of the subendothelial extracellular matrix (ECM) is attributed to sequestration of basic fibroblast growth factor (bFGF) by heparan sulfate proteoglycans and its regulated release by heparin-like molecules and heparan sulfate (HS) degrading enzymes.	Heparitin Sulfate	257-259	fibroblast growth factor 2	Homo sapiens	113-143
8617759-1	1996	The growth promoting activity of the subendothelial extracellular matrix (ECM) is attributed to sequestration of basic fibroblast growth factor (bFGF) by heparan sulfate proteoglycans and its regulated release by heparin-like molecules and heparan sulfate (HS) degrading enzymes.	Heparitin Sulfate	257-259	fibroblast growth factor 2	Homo sapiens	145-149
8641011-0	1996	Heparin and heparan sulfate block angiotensin II-induced hypertrophy in cultured neonatal rat cardiomyocytes.	Heparitin Sulfate	12-27	angiotensinogen	Rattus norvegicus	34-48
8821828-0	1996	Inhibition of mitogenesis and c-fos induction in mesangial cells by heparin and heparan sulfates.	Heparitin Sulfate	80-96	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-35
8636224-0	1996	Heparan sulfate expression in polarized epithelial cells: the apical sorting of glypican (GPI-anchored proteoglycan) is inversely related to its heparan sulfate content.	Heparitin Sulfate	0-15	glypican 1	Homo sapiens	80-88
8636224-0	1996	Heparan sulfate expression in polarized epithelial cells: the apical sorting of glypican (GPI-anchored proteoglycan) is inversely related to its heparan sulfate content.	Heparitin Sulfate	145-160	glypican 1	Homo sapiens	80-88
8636224-3	1996	Domain-specific biotinylation of the apical and basolateral membranes of these cells identified glypican, a GPI-linked heparan sulfate proteoglycan, as the major source of apical heparan sulfate.	Heparitin Sulfate	119-134	glypican 1	Homo sapiens	96-104
8636224-3	1996	Domain-specific biotinylation of the apical and basolateral membranes of these cells identified glypican, a GPI-linked heparan sulfate proteoglycan, as the major source of apical heparan sulfate.	Heparitin Sulfate	179-194	glypican 1	Homo sapiens	96-104
8636224-7	1996	Yet, complete removal of the heparan sulfate glycanation sites from the glypican core protein resulted in the nearly exclusive apical targeting of glypican in the transfectants, whereas two- and one-chain mutant forms had intermediate distributions.	Heparitin Sulfate	29-44	glypican 1	Homo sapiens	72-80
8636224-7	1996	Yet, complete removal of the heparan sulfate glycanation sites from the glypican core protein resulted in the nearly exclusive apical targeting of glypican in the transfectants, whereas two- and one-chain mutant forms had intermediate distributions.	Heparitin Sulfate	29-44	glypican 1	Homo sapiens	147-155
8636224-8	1996	These results indicate that glypican accounts for the expression of apical heparan sulfate, but that glycanation of the core protein antagonizes the activity of the apical sorting signal conveyed by the GPI anchor of this proteoglycan.	Heparitin Sulfate	75-90	glypican 1	Homo sapiens	28-36
8636224-9	1996	A possible implication of these findings is that heparan sulfate glycanation may be a determinant of the subcellular expression of glypican.	Heparitin Sulfate	49-64	glypican 1	Homo sapiens	131-139
8603018-4	1996	Using recently developed sensitive assays for FXIa-inhibitor complexes we found thrombin-mediated and FXII-dependent activation of endogenous FXI in plasma in the presence of heparan sulphate, heparin, dermatan sulphate or dextran sulphate.	Heparitin Sulfate	175-191	coagulation factor II, thrombin	Homo sapiens	80-88
8603018-4	1996	Using recently developed sensitive assays for FXIa-inhibitor complexes we found thrombin-mediated and FXII-dependent activation of endogenous FXI in plasma in the presence of heparan sulphate, heparin, dermatan sulphate or dextran sulphate.	Heparitin Sulfate	175-191	coagulation factor XI	Homo sapiens	46-49
8603018-5	1996	Using heparan sulphate, which is present in the human vascular system, activation of about 1-2% of plasma FXI was observed, however, only after addition of very high amounts (500 nmol/l) of human alpha-thrombin to FXII-deficient plasma (at a 1 to 4 final dilution).	Heparitin Sulfate	6-22	coagulation factor XI	Homo sapiens	106-109
8603018-5	1996	Using heparan sulphate, which is present in the human vascular system, activation of about 1-2% of plasma FXI was observed, however, only after addition of very high amounts (500 nmol/l) of human alpha-thrombin to FXII-deficient plasma (at a 1 to 4 final dilution).	Heparitin Sulfate	6-22	coagulation factor II, thrombin	Homo sapiens	202-210
8603018-6	1996	We conclude that endogenous FXI in plasma can be activated by thrombin in the presence of various glycosaminoglycans, including the physiological compounds heparan sulphate and dermatan sulphate, but only at very high concentrations of thrombin, corresponding to 100% prothrombin activation in undiluted plasma.	Heparitin Sulfate	156-172	coagulation factor XI	Homo sapiens	28-31
8603018-6	1996	We conclude that endogenous FXI in plasma can be activated by thrombin in the presence of various glycosaminoglycans, including the physiological compounds heparan sulphate and dermatan sulphate, but only at very high concentrations of thrombin, corresponding to 100% prothrombin activation in undiluted plasma.	Heparitin Sulfate	156-172	coagulation factor II, thrombin	Homo sapiens	62-70
8838671-9	1996	Fibroblasts responded to the addition of dermatan sulfate, heparan sulfate and heparin with a decrease in fibronectin, collagenase and interleukin-6 mRNA.	Heparitin Sulfate	59-74	fibronectin 1	Homo sapiens	106-117
8838671-9	1996	Fibroblasts responded to the addition of dermatan sulfate, heparan sulfate and heparin with a decrease in fibronectin, collagenase and interleukin-6 mRNA.	Heparitin Sulfate	59-74	interleukin 6	Homo sapiens	135-148
8601723-4	1996	At 37 degree C and pH 7.2, radioactively labeled MIP-1 beta, RANTES, and heparanase bound to confluent layers of resting keratinocytes in a saturable and an heparan sulfate- or heparin-dependent manner, and thereby induced the adhesion of resting CD4+ T cells to keratinocytes.	Heparitin Sulfate	157-172	C-C motif chemokine ligand 4	Homo sapiens	49-59
8601723-4	1996	At 37 degree C and pH 7.2, radioactively labeled MIP-1 beta, RANTES, and heparanase bound to confluent layers of resting keratinocytes in a saturable and an heparan sulfate- or heparin-dependent manner, and thereby induced the adhesion of resting CD4+ T cells to keratinocytes.	Heparitin Sulfate	157-172	C-C motif chemokine ligand 5	Homo sapiens	61-67
8821828-11	1996	We conclude that low concentrations of heparin and heparan sulfate suppress the mitogenic response of mesangial cells to serum and inhibit c-fos mRNA induction through an effect of cell surface-bound glycosaminoglycan on a signalling pathway downstream of PKC.	Heparitin Sulfate	51-66	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	139-144
8567685-0	1996	Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface.	Heparitin Sulfate	149-164	pleiotrophin	Rattus norvegicus	46-88
8567685-0	1996	Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface.	Heparitin Sulfate	149-164	pleiotrophin	Rattus norvegicus	90-96
8567685-0	1996	Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface.	Heparitin Sulfate	149-164	pleiotrophin	Rattus norvegicus	137-143
8567685-2	1996	Because N-syndecan (syndecan-3) was found to function as a receptor in HB-GAM-induced neurite outgrowth, we have now studied whether the heparan sulfate side chains of N-syndecan play a role in HB-GAM-neuron interactions.	Heparitin Sulfate	137-152	syndecan 3	Rattus norvegicus	168-178
8567685-9	1996	Structural analysis of N-syndecan from 6-day-old rat brain indicated that the heparan sulfate chains contain sequences of contiguous, N-sulfated disaccharide units with an unusually high proportion (82%) of 2-O-sulfated iduronic acid residues.	Heparitin Sulfate	78-93	syndecan 3	Rattus norvegicus	23-33
8567685-10	1996	We suggest that this property of N-syndecan heparan sulfate is essential for HB-GAM binding and induction of neurite outgrowth.	Heparitin Sulfate	44-59	syndecan 3	Rattus norvegicus	33-43
8567685-10	1996	We suggest that this property of N-syndecan heparan sulfate is essential for HB-GAM binding and induction of neurite outgrowth.	Heparitin Sulfate	44-59	pleiotrophin	Rattus norvegicus	77-83
8547648-0	1996	Human leukemia cell lines bind basic fibroblast growth factor (FGF) on FGF receptors and heparan sulfates: downmodulation of FGF receptors by phorbol ester.	Heparitin Sulfate	89-105	fibroblast growth factor 2	Homo sapiens	31-61
9164657-11	1996	Taken together, the above findings suggest that vitronectin"s binding to the matrix and its subsequent degradation are dependent on heparan sulfate proteoglycans.	Heparitin Sulfate	132-147	vitronectin	Homo sapiens	48-59
8689765-12	1996	Heparan sulphate binds antithrombin III (ATIII), thereby accelerating inactivation of intrinsic coagulation enzymes.	Heparitin Sulfate	0-16	serpin family C member 1	Homo sapiens	23-39
8689765-12	1996	Heparan sulphate binds antithrombin III (ATIII), thereby accelerating inactivation of intrinsic coagulation enzymes.	Heparitin Sulfate	0-16	serpin family C member 1	Homo sapiens	41-46
8536692-11	1995	The results suggest a bFGF-dependent change in the rate of synthesis and structural features of the membrane-associated heparan sulfate in corneal endothelial cells.	Heparitin Sulfate	120-135	fibroblast growth factor 2	Homo sapiens	22-26
7494002-3	1995	Heparan sulfate (HS)-conjugated gel also bound HGF, and the binding was competitively inhibited by heparin and bovine liver HS, but not by Engelbreth-Holm-Swarm sarcoma HS, pig aorta HS, or other glycosaminoglycans, suggesting the specific structural domain in HS for the binding of HGF.	Heparitin Sulfate	0-15	hepatocyte growth factor	Bos taurus	47-50
7494002-3	1995	Heparan sulfate (HS)-conjugated gel also bound HGF, and the binding was competitively inhibited by heparin and bovine liver HS, but not by Engelbreth-Holm-Swarm sarcoma HS, pig aorta HS, or other glycosaminoglycans, suggesting the specific structural domain in HS for the binding of HGF.	Heparitin Sulfate	0-15	hepatocyte growth factor	Sus scrofa	283-286
7494002-3	1995	Heparan sulfate (HS)-conjugated gel also bound HGF, and the binding was competitively inhibited by heparin and bovine liver HS, but not by Engelbreth-Holm-Swarm sarcoma HS, pig aorta HS, or other glycosaminoglycans, suggesting the specific structural domain in HS for the binding of HGF.	Heparitin Sulfate	17-19	hepatocyte growth factor	Bos taurus	47-50
7494002-3	1995	Heparan sulfate (HS)-conjugated gel also bound HGF, and the binding was competitively inhibited by heparin and bovine liver HS, but not by Engelbreth-Holm-Swarm sarcoma HS, pig aorta HS, or other glycosaminoglycans, suggesting the specific structural domain in HS for the binding of HGF.	Heparitin Sulfate	17-19	hepatocyte growth factor	Sus scrofa	283-286
8536692-0	1995	Basic fibroblast growth factor controls the expression and molecular structure of heparan sulfate in corneal endothelial cells.	Heparitin Sulfate	82-97	fibroblast growth factor 2	Bos taurus	0-30
8536692-7	1995	In control cells, cell-associated heparan sulfate accounts for about 30% of the total glycosaminoglycans, whereas under the influence of bFGF the amount of heparan sulfate increases to approximately 60%.	Heparitin Sulfate	156-171	fibroblast growth factor 2	Homo sapiens	137-141
8609052-11	1996	Heparitinase/chlorate, which digests the heparan sulfate proteoglycan of the endothelial cell surface, restored both t-PA and PAI-1 mRNA levels in response to HB-EGF in a manner similar to that by EGF.	Heparitin Sulfate	41-56	plasminogen activator, tissue type	Homo sapiens	117-121
8609052-11	1996	Heparitinase/chlorate, which digests the heparan sulfate proteoglycan of the endothelial cell surface, restored both t-PA and PAI-1 mRNA levels in response to HB-EGF in a manner similar to that by EGF.	Heparitin Sulfate	41-56	serpin family E member 1	Homo sapiens	126-131
8609052-11	1996	Heparitinase/chlorate, which digests the heparan sulfate proteoglycan of the endothelial cell surface, restored both t-PA and PAI-1 mRNA levels in response to HB-EGF in a manner similar to that by EGF.	Heparitin Sulfate	41-56	epidermal growth factor	Homo sapiens	162-165
9117264-3	1996	These extracellular ligands utilize the heparan sulfate chains of N-syndecan for binding.	Heparitin Sulfate	40-55	syndecan 3	Rattus norvegicus	66-76
9117266-6	1996	In addition, other potential roles for the heparan sulfate chains of agrin during nervous system development are explored.	Heparitin Sulfate	43-58	agrin	Homo sapiens	69-74
8713797-3	1996	PSG3 bound also to certain polyanionic substances, such as double-stranded DNA, heparan sulfate, dextran sulfate and acetylated-LDL, but not to other polyanionic substances.	Heparitin Sulfate	80-95	pregnancy specific beta-1-glycoprotein 3	Homo sapiens	0-4
8713797-4	1996	The binding of PSG3 to GPIIIa was completely inhibited by heparan sulfate and dextran sulfate, indicating that PSG3 recognizes a particular array of negative charges expressed on both GPIIIa and the specified polyanionic substances.	Heparitin Sulfate	58-73	pregnancy specific beta-1-glycoprotein 3	Homo sapiens	15-19
8713797-4	1996	The binding of PSG3 to GPIIIa was completely inhibited by heparan sulfate and dextran sulfate, indicating that PSG3 recognizes a particular array of negative charges expressed on both GPIIIa and the specified polyanionic substances.	Heparitin Sulfate	58-73	integrin subunit beta 3	Homo sapiens	23-29
8713797-4	1996	The binding of PSG3 to GPIIIa was completely inhibited by heparan sulfate and dextran sulfate, indicating that PSG3 recognizes a particular array of negative charges expressed on both GPIIIa and the specified polyanionic substances.	Heparitin Sulfate	58-73	pregnancy specific beta-1-glycoprotein 3	Homo sapiens	111-115
8713797-4	1996	The binding of PSG3 to GPIIIa was completely inhibited by heparan sulfate and dextran sulfate, indicating that PSG3 recognizes a particular array of negative charges expressed on both GPIIIa and the specified polyanionic substances.	Heparitin Sulfate	58-73	integrin subunit beta 3	Homo sapiens	184-190
8835301-3	1995	Like heparin or heparan sulfates, heparan-like molecules, named carboxymethyl-benzylamide-sulfonated dextrans (CMDBS), are known to potentiate fibroblast growth factor activities by stabilizing them against pH, thermal or proteolytic denaturations, and by enhancing their binding with cell surface receptors.	Heparitin Sulfate	16-32	myotrophin	Rattus norvegicus	154-167
8747085-4	1995	TGF beta 1 induced a more marked increase in collagen and fibronectin release and greater production of sulphated GAGs as DS and heparan sulphate (HS) in the otosclerotic cells.	Heparitin Sulfate	129-145	transforming growth factor beta 1	Homo sapiens	0-10
8747085-4	1995	TGF beta 1 induced a more marked increase in collagen and fibronectin release and greater production of sulphated GAGs as DS and heparan sulphate (HS) in the otosclerotic cells.	Heparitin Sulfate	147-149	transforming growth factor beta 1	Homo sapiens	0-10
8536692-8	1995	At the same time, the molecular structure of the heparan sulfate molecule undergoes bFGF-specific changes as indicated by the [35S]oligosaccharide pattern generated by heparitinase I degradation.	Heparitin Sulfate	49-64	fibroblast growth factor 2	Homo sapiens	84-88
8536692-12	1995	The modification of the heparan sulfate structure could influence its bFGF-binding and antiproliferative activity.	Heparitin Sulfate	24-39	fibroblast growth factor 2	Homo sapiens	70-74
8808095-0	1995	Degradation of cell surface heparan sulfates decreases the high affinity binding of basic FGF to endothelial cells, but not to FRTL-5 rat thyroid cells.	Heparitin Sulfate	28-44	fibroblast growth factor 2	Rattus norvegicus	90-93
8713482-3	1995	Heparan sulfate chains consisting of alternately arranged N-acetylated or N-sulfated glucosamine and uronic acid disaccharide regions, covalently attached to a core protein are found in two major families of cell surface HSPG, the syndecans and glypicans.	Heparitin Sulfate	0-15	syndecan 2	Homo sapiens	221-225
7592957-10	1995	The data suggest that the secreted and/or cell surface-bound apoE interact with the lipoproteins and facilitate their internalization via the heparan sulfate proteoglycan-LRP pathway.	Heparitin Sulfate	142-157	apolipoprotein E	Mus musculus	61-65
7592957-10	1995	The data suggest that the secreted and/or cell surface-bound apoE interact with the lipoproteins and facilitate their internalization via the heparan sulfate proteoglycan-LRP pathway.	Heparitin Sulfate	142-157	low density lipoprotein receptor-related protein 1	Mus musculus	171-174
8594987-1	1995	Basic fibroblast growth factor (bFGF) is a member of the heparin-binding growth factor family that interacts with cell surface heparan sulfate (HS) proteoglycans and extracellular matrix heparin.	Heparitin Sulfate	127-142	fibroblast growth factor 2	Homo sapiens	0-30
8594987-1	1995	Basic fibroblast growth factor (bFGF) is a member of the heparin-binding growth factor family that interacts with cell surface heparan sulfate (HS) proteoglycans and extracellular matrix heparin.	Heparitin Sulfate	127-142	fibroblast growth factor 2	Homo sapiens	32-36
8594987-1	1995	Basic fibroblast growth factor (bFGF) is a member of the heparin-binding growth factor family that interacts with cell surface heparan sulfate (HS) proteoglycans and extracellular matrix heparin.	Heparitin Sulfate	144-146	fibroblast growth factor 2	Homo sapiens	32-36
8594987-1	1995	Basic fibroblast growth factor (bFGF) is a member of the heparin-binding growth factor family that interacts with cell surface heparan sulfate (HS) proteoglycans and extracellular matrix heparin.	Heparitin Sulfate	144-146	fibroblast growth factor 2	Homo sapiens	0-30
8594987-2	1995	Here we report the development of a simple and sensitive assay that used biotinylated HS or heparin to bind to bFGF coated onto 96-well microtiter plates.	Heparitin Sulfate	86-88	fibroblast growth factor 2	Homo sapiens	111-115
7559620-0	1995	Heparan sulfates mediate the binding of basic fibroblast growth factor to a specific receptor on neural precursor cells.	Heparitin Sulfate	0-16	fibroblast growth factor 2	Mus musculus	40-70
7559620-3	1995	In this study, a combination of affinity chromatography and gel chromatography was used to further isolate heparan sulfate side chains with high affinity for FGF-2.	Heparitin Sulfate	107-122	fibroblast growth factor 2	Mus musculus	158-163
7559620-5	1995	In order to determine whether heparan sulfate chains with specificity for FGF-2 also displayed selectivity for the different FGF receptors, peptides designed to the heparin-binding region of the receptors were used in competitive inhibition studies.	Heparitin Sulfate	30-45	fibroblast growth factor 2	Mus musculus	74-79
7559620-5	1995	In order to determine whether heparan sulfate chains with specificity for FGF-2 also displayed selectivity for the different FGF receptors, peptides designed to the heparin-binding region of the receptors were used in competitive inhibition studies.	Heparitin Sulfate	30-45	fibroblast growth factor 2	Mus musculus	74-77
7487873-0	1995	Transforming growth factor-beta 1 increases internalization of basic fibroblast growth factor by smooth muscle cells: implication of cell-surface heparan sulphate proteoglycan endocytosis.	Heparitin Sulfate	146-162	transforming growth factor beta 1	Sus scrofa	0-33
7487873-5	1995	Although bFGF and/or TGF-beta 1 induced a similar stimulation in cell-surface chondroitin sulphate/dermatan sulphate and heparan sulphate (HS) proteoglycan synthesis, only the turnover of HS proteoglycans was increased.	Heparitin Sulfate	121-137	transforming growth factor beta 1	Sus scrofa	21-31
7487873-5	1995	Although bFGF and/or TGF-beta 1 induced a similar stimulation in cell-surface chondroitin sulphate/dermatan sulphate and heparan sulphate (HS) proteoglycan synthesis, only the turnover of HS proteoglycans was increased.	Heparitin Sulfate	139-141	transforming growth factor beta 1	Sus scrofa	21-31
7592623-4	1995	FGF-2-dependent attachment of 32D-flg cells was prevented by inclusion of 10 micrograms/ml heparin in the incubation medium and was diminished when CHO mutants in glycosaminoglycan synthesis or wild-type CHO cells treated with heparinase were used, indicating that the attachment occurred through FGF-2 interactions with heparan sulfates on the CHO cells.	Heparitin Sulfate	321-337	fibroblast growth factor 2	Cricetulus griseus	0-5
7592623-8	1995	We conclude that attachment is due to FGF-2 binding simultaneously to receptors on the 32D-flg cells and heparan sulfates on the CHO monolayers; thus, the FGF-2 acts as a bridge between receptor-expressing cells and heparan sulfate-bearing cells.	Heparitin Sulfate	105-121	fibroblast growth factor 2	Cricetulus griseus	155-160
7592670-0	1995	Heparan sulfate proteoglycans are primarily responsible for the maintenance of enzyme activity, binding, and degradation of lipoprotein lipase in Chinese hamster ovary cells.	Heparitin Sulfate	0-15	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	124-142
7592623-8	1995	We conclude that attachment is due to FGF-2 binding simultaneously to receptors on the 32D-flg cells and heparan sulfates on the CHO monolayers; thus, the FGF-2 acts as a bridge between receptor-expressing cells and heparan sulfate-bearing cells.	Heparitin Sulfate	105-120	fibroblast growth factor 2	Cricetulus griseus	155-160
7592623-9	1995	In addition, induction of DNA synthesis in 32D-flg cells in response to FGF-2 was potentiated by the CHO-associated heparan sulfates to the same extent as by soluble heparin, indicating that this interaction has functional significance.	Heparitin Sulfate	116-132	fibroblast growth factor 2	Cricetulus griseus	72-77
7583544-7	1995	Compared with heparan sulfate isolated from control SMCs, heparan sulfate isolated from STZ-SMCs was of smaller molecular size and caused a greater mitogenic effect of HB-EGF.	Heparitin Sulfate	58-73	heparin-binding EGF-like growth factor	Rattus norvegicus	168-174
7583544-9	1995	Changes in cell-associated heparan sulfate in STZ-SMCs may be related to the increased mitogenic response to HB-EGF.	Heparitin Sulfate	27-42	heparin-binding EGF-like growth factor	Rattus norvegicus	109-115
7654188-1	1995	Interferon (IFN)-gamma, in common with a number of cytokines or growth factors, strongly interacts with heparan sulphate (HS).	Heparitin Sulfate	104-120	interferon gamma	Homo sapiens	0-22
8520854-2	1995	Removal of chylomicron remnants by the liver involves interaction with several macromolecules on the cell surface, including the LDL receptor and heparan-sulfate-bound hepatic lipase and apolipoprotein E.	Heparitin Sulfate	146-161	lipase C, hepatic type	Homo sapiens	168-182
7556568-6	1995	The developmental expression of syndecans is particularly intense in mesenchymal condensates and at epithelium mesenchyme interfaces, where a number of heparan sulphate-binding cytokines and matrix components are also expressed in a regulated manner, often spatially and temporally co-ordinated with the syndecan expression.	Heparitin Sulfate	152-168	syndecan 1	Homo sapiens	32-40
7556568-7	1995	Recent evidence indicates that the regulation of heparan sulphate fine structure (mainly the number and arrangement of sulphate groups along the polymer) provides a mechanism for the cellular control of syndecan-protein interactions.	Heparitin Sulfate	49-65	syndecan 1	Homo sapiens	203-211
8593123-6	1995	Sequestration in the liver through lipoprotein lipase and/or apoE-mediated binding to heparan sulphate ("bridging" effect) appears to play an exceedingly important role during the early phase of the remnant clearance process.	Heparitin Sulfate	86-102	apolipoprotein E	Rattus norvegicus	61-65
7654188-1	1995	Interferon (IFN)-gamma, in common with a number of cytokines or growth factors, strongly interacts with heparan sulphate (HS).	Heparitin Sulfate	122-124	interferon gamma	Homo sapiens	0-22
7654188-5	1995	This led us to take a "footprinting" approach in which HS was depolymerized in the presence of IFN-gamma and the cytokine-protected sequences were separated from the digested fragments.	Heparitin Sulfate	55-57	interferon gamma	Homo sapiens	95-104
7654188-12	1995	Furthermore, using a cross-linking strategy, we demonstrated that one HS molecule bound to an IFN-gamma dimer.	Heparitin Sulfate	70-72	interferon gamma	Homo sapiens	94-103
8530090-1	1995	Iduronate-2-sulfatase (IDS) is involved in the degradation of heparan sulfate and dermatan sulfate in the lysosomes, and a deficiency in this enzyme results in Hunter syndrome.	Heparitin Sulfate	62-77	iduronate 2-sulfatase	Homo sapiens	0-21
7554444-0	1995	Cytotoxicity to endothelial cells by sera from aged MRL/lpr/lpr mice is associated with autoimmunity to cell surface heparan sulfate.	Heparitin Sulfate	117-132	Fas (TNF receptor superfamily member 6)	Mus musculus	56-59
7554444-0	1995	Cytotoxicity to endothelial cells by sera from aged MRL/lpr/lpr mice is associated with autoimmunity to cell surface heparan sulfate.	Heparitin Sulfate	117-132	Fas (TNF receptor superfamily member 6)	Mus musculus	60-63
7554444-4	1995	These MRL/lpr/lpr sera induced complement-dependent cleavage and release of 35SO4-labeled material containing primarily cell surface heparan sulfate proteoglycans from these cells, and react with heparin (a glycosaminoglycan related to heparan sulfate) by ELISA and liquid-phase competitive inhibition ELISA.	Heparitin Sulfate	133-148	Fas (TNF receptor superfamily member 6)	Mus musculus	10-13
7554444-4	1995	These MRL/lpr/lpr sera induced complement-dependent cleavage and release of 35SO4-labeled material containing primarily cell surface heparan sulfate proteoglycans from these cells, and react with heparin (a glycosaminoglycan related to heparan sulfate) by ELISA and liquid-phase competitive inhibition ELISA.	Heparitin Sulfate	133-148	Fas (TNF receptor superfamily member 6)	Mus musculus	14-17
7554444-4	1995	These MRL/lpr/lpr sera induced complement-dependent cleavage and release of 35SO4-labeled material containing primarily cell surface heparan sulfate proteoglycans from these cells, and react with heparin (a glycosaminoglycan related to heparan sulfate) by ELISA and liquid-phase competitive inhibition ELISA.	Heparitin Sulfate	236-251	Fas (TNF receptor superfamily member 6)	Mus musculus	10-13
7554444-4	1995	These MRL/lpr/lpr sera induced complement-dependent cleavage and release of 35SO4-labeled material containing primarily cell surface heparan sulfate proteoglycans from these cells, and react with heparin (a glycosaminoglycan related to heparan sulfate) by ELISA and liquid-phase competitive inhibition ELISA.	Heparitin Sulfate	236-251	Fas (TNF receptor superfamily member 6)	Mus musculus	14-17
8530090-1	1995	Iduronate-2-sulfatase (IDS) is involved in the degradation of heparan sulfate and dermatan sulfate in the lysosomes, and a deficiency in this enzyme results in Hunter syndrome.	Heparitin Sulfate	62-77	iduronate 2-sulfatase	Homo sapiens	23-26
8527239-11	1995	These findings suggest that: 1) stratum intermedium cells and papillary layer cells express CD44 and HS chains in accordance with their differentiation; 2) HS chains on the plasma membrane of these cells may regulate calcium transport by their negative charge; and 3) HS chains on the stratum intermedium and papillary layer may play an important role in the differentiation and activity of ameloblasts by preserving HBGF.	Heparitin Sulfate	156-158	CD44 molecule (Indian blood group)	Rattus norvegicus	92-96
7559767-4	1995	Heparin affinity resins immunoprecipitate Mac-1, and neutrophils and transfectant cells that express Mac-1 bind to heparin and heparan sulfate, but not to other sulfated glycosaminoglycans.	Heparitin Sulfate	127-142	integrin subunit alpha M	Homo sapiens	101-106
7657705-4	1995	The novel molecule, named K-glypican, has a predicted molecular mass of 57.5 kD and potential attachment sites for heparan sulfate chains and a GPI anchor in its COOH-terminal region, like other members of the glypican family.	Heparitin Sulfate	115-130	glypican 4	Mus musculus	26-36
8581561-6	1995	Heparan sulphate proteoglycan (HSPG) core protein and intercellular adhesion molecule-1 (ICAM-1) are absent in the diffuse A beta plaques in the AD cerebellum.	Heparitin Sulfate	0-16	amyloid beta precursor protein	Homo sapiens	123-129
8527239-11	1995	These findings suggest that: 1) stratum intermedium cells and papillary layer cells express CD44 and HS chains in accordance with their differentiation; 2) HS chains on the plasma membrane of these cells may regulate calcium transport by their negative charge; and 3) HS chains on the stratum intermedium and papillary layer may play an important role in the differentiation and activity of ameloblasts by preserving HBGF.	Heparitin Sulfate	156-158	CD44 molecule (Indian blood group)	Rattus norvegicus	92-96
7593307-9	1995	Analyses of the proteoglycan fractions from the extracts of bovine articular surface indicated that perlecan in this tissue contains both chondroitin and heparan sulfate side-chains.	Heparitin Sulfate	154-169	heparan sulfate proteoglycan 2	Bos taurus	100-108
7643195-2	1995	Since heparan sulfate-proteoglycan is a major component of the extracellular matrix of skeletal muscle, factors that are bound to this proteoglycan, such as basic fibroblast growth factor (bFGF), are in a strategic position for neuronal signaling.	Heparitin Sulfate	6-21	fibroblast growth factor 2 L homeolog	Xenopus laevis	157-187
7643195-2	1995	Since heparan sulfate-proteoglycan is a major component of the extracellular matrix of skeletal muscle, factors that are bound to this proteoglycan, such as basic fibroblast growth factor (bFGF), are in a strategic position for neuronal signaling.	Heparitin Sulfate	6-21	fibroblast growth factor 2 L homeolog	Xenopus laevis	189-193
7622503-4	1995	Incubation of HGF with 0.1, 1.0, and 10 micrograms/ml of heparin, heparan sulfate, or dextran sulfate resulted in a concentration-dependent increase in mitogenic potency in a primary rat hepatocyte bioassay, whereas sodium sulfate or fucoidan did not.	Heparitin Sulfate	66-81	hepatocyte growth factor	Rattus norvegicus	14-17
8589216-7	1995	Heparan sulphate preparations less effectively increased the rate of thrombin inhibition than did the other low-affinity polysaccharides.	Heparitin Sulfate	0-16	coagulation factor II, thrombin	Homo sapiens	69-77
8589216-9	1995	The observed effects of the heparan sulphates on this anticoagulant pathway, although of low potency, are consistent with the hypotheses that these substances naturally regulate blood homeostasis in vascular tissues and that much of this function may be mediated by the higher-affinity antithrombin III isoform.	Heparitin Sulfate	28-45	serpin family C member 1	Homo sapiens	286-302
7500917-5	1995	ATIII bound specifically to heparan sulfate residues on the surface of herpesvirus-permissive RK13 cells.	Heparitin Sulfate	28-43	serpin family C member 1	Homo sapiens	0-5
7626005-1	1995	Iduronate 2-sulphatase (IDS) is a lysosomal enzyme involved in degradation of dermatan sulphate and heparan sulphate.	Heparitin Sulfate	100-116	iduronate 2-sulfatase	Homo sapiens	0-22
7626005-1	1995	Iduronate 2-sulphatase (IDS) is a lysosomal enzyme involved in degradation of dermatan sulphate and heparan sulphate.	Heparitin Sulfate	100-116	iduronate 2-sulfatase	Homo sapiens	24-27
7619084-4	1995	The putative N-terminal ectodomain contains a possible attachment site for heparan sulphate, identical with the comparable glycosaminoglycan-attachment sequence of rat syndecan 2.	Heparitin Sulfate	75-91	syndecan 2	Rattus norvegicus	168-178
8714389-2	1995	Activation of erythropoiesis with the erythropoietin induced an expression of heparin-sulfate.	Heparitin Sulfate	78-93	erythropoietin	Homo sapiens	38-52
7548979-2	1995	Animal studies have shown that, besides diminishing the glomerular capillary pressure, ACE inhibitors might reduce albuminuria by influencing glomerular charge selectivity through glomerular preservation of heparan sulphate proteoglycan.	Heparitin Sulfate	207-223	angiotensin I converting enzyme	Homo sapiens	87-90
7793988-1	1995	Previous studies have demonstrated the immunolocalization of perlecan, a specific heparan sulfate proteoglycan, to the beta-amyloid protein (A beta)-containing amyloid deposits within the walls of blood vessels (i.e., congophilic angiopathy) in Alzheimer"s disease (AD) brain.	Heparitin Sulfate	82-97	amyloid beta precursor protein	Homo sapiens	141-147
7790815-6	1995	Soluble CSA inhibited binding to CHO cells by 99.2 +/- 0.2% at 10 mg/ml and by 72.5 +/- 3.8% at 1 mg/ml, whereas a range of other glycosaminoglycans such as heparan sulfate had no effect.	Heparitin Sulfate	157-172	chorionic somatomammotropin hormone 1	Homo sapiens	8-11
7790818-0	1995	The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation.	Heparitin Sulfate	53-68	C-X-C motif chemokine ligand 10	Homo sapiens	4-9
7790818-5	1995	This conclusion is based on the findings that IP-10 binding to cells is: (a) inhibited by heparin and heparan sulfate; (b) sensitive to a 1 M NaCl wash; (c) eliminated by treatment with heparinase and trypsin; and (d) absent on mutant CHO cells that do not express cell surface HSPG.	Heparitin Sulfate	102-117	C-X-C motif chemokine ligand 10	Homo sapiens	46-51
8590594-1	1995	High-affinity binding of basic fibroblast growth factor (bFGF) to the tyrosine kinase receptor requires cell-surface heparan sulfate proteoglycan or exogenous addition of heparin.	Heparitin Sulfate	117-132	fibroblast growth factor 2	Homo sapiens	25-55
8590594-1	1995	High-affinity binding of basic fibroblast growth factor (bFGF) to the tyrosine kinase receptor requires cell-surface heparan sulfate proteoglycan or exogenous addition of heparin.	Heparitin Sulfate	117-132	fibroblast growth factor 2	Homo sapiens	57-61
7797576-10	1995	These results indicate that the VLDL receptor recognizes both triglyceride-rich lipoproteins that are also relatively rich in apoE, as well as the remnants of triglyceride-rich lipoproteins after catabolism and the interaction with heparan sulfate proteoglycans by LPL.	Heparitin Sulfate	232-247	very low density lipoprotein receptor	Homo sapiens	32-45
7797576-10	1995	These results indicate that the VLDL receptor recognizes both triglyceride-rich lipoproteins that are also relatively rich in apoE, as well as the remnants of triglyceride-rich lipoproteins after catabolism and the interaction with heparan sulfate proteoglycans by LPL.	Heparitin Sulfate	232-247	lipoprotein lipase	Homo sapiens	265-268
7797488-5	1995	These results indicate that PF4 may inhibit VEGF165 binding to VEGF receptors by disrupting the interaction of VEGF165 with cell surface heparan sulfates.	Heparitin Sulfate	137-153	platelet factor 4	Homo sapiens	28-31
7663435-1	1995	The iduronate-2-sulfatase (IDS) is a lysosomal enzyme that acts on sulphate groups on C-2 positions of the iduronic acid residues of the mucopolysaccharides heparan sulphate and dermatan sulphate.	Heparitin Sulfate	157-173	iduronate 2-sulfatase	Homo sapiens	4-25
7779094-0	1995	Formation of heparan sulfate or chondroitin/dermatan sulfate on recombinant domain I of mouse perlecan expressed in Chinese hamster ovary cells.	Heparitin Sulfate	13-28	LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein	Cricetulus griseus	94-102
7664755-10	1995	The results indicate that the bFGF-induced proliferation of arterial smooth muscle cells depends on the pericellular localization of bFGF and on a specific molecular organization of the cell surface heparan sulfate.	Heparitin Sulfate	199-214	fibroblast growth factor 2	Bos taurus	30-34
7664755-11	1995	Depending on its specific structural characteristics heparan sulfate may promote or inhibit bFGF receptor binding and signal transduction.	Heparitin Sulfate	53-68	fibroblast growth factor 2	Bos taurus	92-96
7796887-8	1995	The remaining RIHB can be removed partially by incubation with heparitinase I or III and completely when the incubation is performed with chondoitinase A, B, C. These results demonstrate that RIHB binds to embryonal chondrocytes and cartilage primarily through proteoglycans of both heparan sulfate and chondroitin sulfate types.	Heparitin Sulfate	283-298	midkine (neurite growth-promoting factor 2)	Gallus gallus	192-196
7779869-11	1995	Earlier, syndecan-1 was described as a hybrid proteoglycan containing heparan sulfate/chondroitin sulfate chains which is transcribed by murine B cells at early and late maturation stages.	Heparitin Sulfate	70-85	syndecan 1	Mus musculus	9-19
7744769-0	1995	VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells.	Heparitin Sulfate	116-132	vascular endothelial growth factor A	Homo sapiens	0-4
7744769-0	1995	VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells.	Heparitin Sulfate	116-132	vascular endothelial growth factor A	Homo sapiens	47-51
7744762-2	1995	O-Sulfation at C-3 of N-sulfated GlcN units concludes polymer modification and the formation of antithrombin binding regions in the biosynthesis of heparin/heparan sulfate.	Heparitin Sulfate	156-171	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	96-108
7744769-9	1995	These results suggest that cell-surface heparan sulfates may regulate the binding ability of the VEGF receptors of the melanoma cells.	Heparitin Sulfate	40-56	vascular endothelial growth factor A	Homo sapiens	97-101
8589262-2	1995	IL-7 binds to heparin and heparan sulfate, to a lesser extent to dermatan sulfate and does not bind to chondroitin sulfate.	Heparitin Sulfate	26-41	interleukin 7	Mus musculus	0-4
7543903-1	1995	Heparan sulfate proteoglycans on the cell surface act as low affinity binding sites for acidic and basic fibroblast growth factor (FGF) [Moscatelli (1987): J Cell Physiol 131:123-130] and play an important role in the interaction of FGF with the FGF receptor (FGFR).	Heparitin Sulfate	0-15	fibroblast growth factor 1	Mus musculus	131-134
7537691-4	1995	For both cell types, however, it is demonstrated that either endogenous or exogenous heparan sulfate/heparin moieties are essential for FGF-1 to establish receptor binding and mitogen action.	Heparitin Sulfate	85-100	fibroblast growth factor 1	Rattus norvegicus	136-141
7537691-5	1995	Thus, the results suggest that hepatocytes harbor cell surface heparan sulfate moieties that are fully capable of utilizing FGF-1 in the environment.	Heparitin Sulfate	63-78	fibroblast growth factor 1	Rattus norvegicus	124-129
7537691-6	1995	These results raise the possibility that FGF-1 is of differential potency for different cell types according to the nature and/or quantity of cell surface heparan sulfate moieties in vivo.	Heparitin Sulfate	155-170	fibroblast growth factor 1	Rattus norvegicus	41-46
7543903-1	1995	Heparan sulfate proteoglycans on the cell surface act as low affinity binding sites for acidic and basic fibroblast growth factor (FGF) [Moscatelli (1987): J Cell Physiol 131:123-130] and play an important role in the interaction of FGF with the FGF receptor (FGFR).	Heparitin Sulfate	0-15	fibroblast growth factor 1	Mus musculus	233-236
7543903-3	1995	Reciprocal cross blocking studies demonstrated that acidic FGF (aFGF) and basic FGF (bFGF) bind to identical or closely associated heparan sulfate motifs on BALB/c 3T3 cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	131-146	fibroblast growth factor 1	Mus musculus	52-62
7543903-3	1995	Reciprocal cross blocking studies demonstrated that acidic FGF (aFGF) and basic FGF (bFGF) bind to identical or closely associated heparan sulfate motifs on BALB/c 3T3 cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	131-146	fibroblast growth factor 1	Mus musculus	64-68
7543903-3	1995	Reciprocal cross blocking studies demonstrated that acidic FGF (aFGF) and basic FGF (bFGF) bind to identical or closely associated heparan sulfate motifs on BALB/c 3T3 cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	131-146	fibroblast growth factor 2	Mus musculus	74-83
7543903-3	1995	Reciprocal cross blocking studies demonstrated that acidic FGF (aFGF) and basic FGF (bFGF) bind to identical or closely associated heparan sulfate motifs on BALB/c 3T3 cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	131-146	fibroblast growth factor 2	Mus musculus	85-89
7543903-3	1995	Reciprocal cross blocking studies demonstrated that acidic FGF (aFGF) and basic FGF (bFGF) bind to identical or closely associated heparan sulfate motifs on BALB/c 3T3 cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	181-196	fibroblast growth factor 1	Mus musculus	52-62
7722469-2	1995	The ensuing penetration of the ECM is associated with the expression of ECM-degrading enzymes, such as endo-beta-D glucuronidase (heparanase), which cleaves heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	157-172	glucuronidase beta	Homo sapiens	108-128
7722469-2	1995	The ensuing penetration of the ECM is associated with the expression of ECM-degrading enzymes, such as endo-beta-D glucuronidase (heparanase), which cleaves heparan sulfate (HS) proteoglycans.	Heparitin Sulfate	174-176	glucuronidase beta	Homo sapiens	108-128
7543903-3	1995	Reciprocal cross blocking studies demonstrated that acidic FGF (aFGF) and basic FGF (bFGF) bind to identical or closely associated heparan sulfate motifs on BALB/c 3T3 cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	181-196	fibroblast growth factor 1	Mus musculus	64-68
7543903-3	1995	Reciprocal cross blocking studies demonstrated that acidic FGF (aFGF) and basic FGF (bFGF) bind to identical or closely associated heparan sulfate motifs on BALB/c 3T3 cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	181-196	fibroblast growth factor 2	Mus musculus	74-83
7543903-3	1995	Reciprocal cross blocking studies demonstrated that acidic FGF (aFGF) and basic FGF (bFGF) bind to identical or closely associated heparan sulfate motifs on BALB/c 3T3 cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	181-196	fibroblast growth factor 2	Mus musculus	85-89
7543903-4	1995	However, the binding affinity of the two growth factors for these heparan sulfate proteoglycans differs considerably, competition binding data indicating that aFGF has a 4.7-fold lower affinity than bFGF for 3T3 heparan sulfate proteoglycan.	Heparitin Sulfate	66-81	fibroblast growth factor 1	Mus musculus	159-163
7543903-4	1995	However, the binding affinity of the two growth factors for these heparan sulfate proteoglycans differs considerably, competition binding data indicating that aFGF has a 4.7-fold lower affinity than bFGF for 3T3 heparan sulfate proteoglycan.	Heparitin Sulfate	212-227	fibroblast growth factor 1	Mus musculus	159-163
7543903-4	1995	However, the binding affinity of the two growth factors for these heparan sulfate proteoglycans differs considerably, competition binding data indicating that aFGF has a 4.7-fold lower affinity than bFGF for 3T3 heparan sulfate proteoglycan.	Heparitin Sulfate	212-227	fibroblast growth factor 2	Mus musculus	199-203
7543903-5	1995	Subsequent studies of dissociation kinetics demonstrated that bFGF dissociates from the FGFR at least 10-fold slower than aFGF, whereas, following removal of cell surface heparan sulfate proteoglycans by heparinase treatment, the dissociation rate of both FGFs is similar and rapid.	Heparitin Sulfate	171-186	fibroblast growth factor 2	Mus musculus	62-66
7674377-8	1995	We also show that the major brain HSPG binds to a synthetic peptide that encodes the heparan sulfate-binding domain of NCAM, and that monoclonal antibodies to a recently identified chick retinal HSPG recognize this NCAM-binding HSPG.	Heparitin Sulfate	85-100	agrin	Gallus gallus	34-38
7674377-8	1995	We also show that the major brain HSPG binds to a synthetic peptide that encodes the heparan sulfate-binding domain of NCAM, and that monoclonal antibodies to a recently identified chick retinal HSPG recognize this NCAM-binding HSPG.	Heparitin Sulfate	85-100	neural cell adhesion molecule 1	Gallus gallus	119-123
7674377-8	1995	We also show that the major brain HSPG binds to a synthetic peptide that encodes the heparan sulfate-binding domain of NCAM, and that monoclonal antibodies to a recently identified chick retinal HSPG recognize this NCAM-binding HSPG.	Heparitin Sulfate	85-100	agrin	Gallus gallus	195-199
7674377-8	1995	We also show that the major brain HSPG binds to a synthetic peptide that encodes the heparan sulfate-binding domain of NCAM, and that monoclonal antibodies to a recently identified chick retinal HSPG recognize this NCAM-binding HSPG.	Heparitin Sulfate	85-100	neural cell adhesion molecule 1	Gallus gallus	215-219
7674377-8	1995	We also show that the major brain HSPG binds to a synthetic peptide that encodes the heparan sulfate-binding domain of NCAM, and that monoclonal antibodies to a recently identified chick retinal HSPG recognize this NCAM-binding HSPG.	Heparitin Sulfate	85-100	agrin	Gallus gallus	195-199
7674377-9	1995	This HSPG was immunopurified from E10 chick brain using the 6D2 monoclonal antibody, and has been shown to bind an affinity column containing the heparan sulfate-binding peptide of NCAM.	Heparitin Sulfate	146-161	agrin	Gallus gallus	5-9
7674377-9	1995	This HSPG was immunopurified from E10 chick brain using the 6D2 monoclonal antibody, and has been shown to bind an affinity column containing the heparan sulfate-binding peptide of NCAM.	Heparitin Sulfate	146-161	neural cell adhesion molecule 1	Gallus gallus	181-185
7535564-7	1995	Heparin, heparan sulfate, gangliosides (but not chondroitin sulfates A and B and hyaluronic acid), and self-association increased the apparent affinity of mAbIII-10 for soluble fibronectin.	Heparitin Sulfate	9-24	fibronectin 1	Homo sapiens	177-188
7643748-5	1995	Characterization of GAGs in the endothelial cell layer and the conditioned medium revealed that bFGF enhanced both heparan sulfate and the other GAGs to a similar degree.	Heparitin Sulfate	115-130	fibroblast growth factor 2	Bos taurus	96-100
7721830-8	1995	The novel aspect of this molecule is the presence of a terminal alpha-Gal-NAc residue at a position that is normally occupied by beta-GalNAc in chondroitin/dermatan sulfate or by alpha-Glc-NAc in heparin or heparan sulfate chains.	Heparitin Sulfate	207-222	synuclein alpha	Homo sapiens	74-77
7721830-8	1995	The novel aspect of this molecule is the presence of a terminal alpha-Gal-NAc residue at a position that is normally occupied by beta-GalNAc in chondroitin/dermatan sulfate or by alpha-Glc-NAc in heparin or heparan sulfate chains.	Heparitin Sulfate	207-222	synuclein alpha	Homo sapiens	137-140
7605368-0	1995	Binding to heparan sulfate is a major event during catabolism of lipoprotein lipase by HepG2 and other cell cultures.	Heparitin Sulfate	11-26	lipoprotein lipase	Homo sapiens	65-83
7592529-4	1995	Whereas heparan sulfate proteoglycan was found in epithelial tissue as the major proteoglycan therein, it was a minor component in the other tissues.	Heparitin Sulfate	8-23	versican	Gallus gallus	24-36
7605368-5	1995	These findings suggested an important role for heparan sulfate in the process of cell interaction and metabolism of LPL.	Heparitin Sulfate	47-62	lipoprotein lipase	Homo sapiens	116-119
7605368-7	1995	Heparan sulfate-deficient CHO cells show a low capacity to bind and degrade LPL, about 10%-20% that of the wild type cells.	Heparitin Sulfate	0-15	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	76-79
7592529-4	1995	Whereas heparan sulfate proteoglycan was found in epithelial tissue as the major proteoglycan therein, it was a minor component in the other tissues.	Heparitin Sulfate	8-23	versican	Gallus gallus	81-93
7705397-3	1995	Furthermore, it has been shown that IFN-gamma binds with a great affinity to the heparin-like structure of heparan sulfate, which is localized in basement membranes and on cell surfaces.	Heparitin Sulfate	107-122	interferon gamma	Homo sapiens	36-45
7890615-6	1995	Using rotation-mediated aggregation assays, we find that aggregation of syndecan-1-transfected cells is dependent on divalent cations and is inhibited by the following: (i) addition of heparin and heparin-like glycosaminoglycans, (ii) removal of heparan sulfate from the cell surface, or (iii) addition of exogenous purified syndecan-1.	Heparitin Sulfate	246-261	syndecan 1	Homo sapiens	72-82
7890615-7	1995	Mixing of syndecan-1-transfected and control-transfected cells results in aggregates containing both cell types indicating that aggregation occurs through a heterophilic adhesion mechanism in which heparan sulfate chains bind to a counter-receptor present on these cells.	Heparitin Sulfate	198-213	syndecan 1	Homo sapiens	10-20
7890615-8	1995	Importantly, syndecan-4-transfected cells also aggregate in a heparan sulfate-dependent manner, while in contrast, betaglycan-transfected cells aggregate poorly.	Heparitin Sulfate	62-77	syndecan 4	Homo sapiens	13-23
7705397-4	1995	In this study, we analyze the effect of heparin and heparan sulfate on three different IFN-gamma-mediated activities inducible in human glioblastoma cells (87HG31 and 86HG39).	Heparitin Sulfate	52-67	interferon gamma	Homo sapiens	87-96
7876170-1	1995	Heparan sulfate 6-sulfotransferase, which catalyzes the transfer of sulfate from 3"-phosphoadenylyl sulfate to position 6 of N-sulfoglucosamine in heparan sulfate, was purified 10,700-fold to apparent homogeneity with a 40% yield from the serum-free culture medium of Chinese hamster ovary cells.	Heparitin Sulfate	147-162	heparan-sulfate 6-O-sulfotransferase 1	Cricetulus griseus	0-34
7867715-7	1995	Thus, the spread and migration responses of HT1080 cells onto FN fusion peptides require the adjacent coexistence of cell- and heparin-binding domains and are mediated by the interactions between cell surface heparan sulfate and the heparin-binding domain, in concert with the interaction between cell surface integrin and the cell-binding domain.	Heparitin Sulfate	209-224	fibronectin 1	Homo sapiens	62-64
7891149-7	1995	Our results suggest that the FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by heparan sulfate.	Heparitin Sulfate	169-184	fibroblast growth factor 2	Rattus norvegicus	29-34
7815550-5	1995	On the basis of the results of attachment, penetration, and heparin competition assays, the heterologous HBD mediated heparan sulfate-dependent virus attachment, but not to fully wild-type levels.	Heparitin Sulfate	118-133	HBD	Homo sapiens	105-108
7852412-0	1995	CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes.	Heparitin Sulfate	104-119	pro-platelet basic protein	Homo sapiens	15-55
7852412-0	1995	CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes.	Heparitin Sulfate	104-119	pro-platelet basic protein	Homo sapiens	60-91
7852412-2	1995	In this study, purification of a heparan sulfate-degrading enzyme from human platelets led to the discovery that the enzymatic activity residues in at least two members of the platelet basic protein (PBP) family known as connective tissue activating peptide-III (CTAP-III) and neutrophil activating peptide-2.	Heparitin Sulfate	33-48	pro-platelet basic protein	Homo sapiens	176-198
7852412-2	1995	In this study, purification of a heparan sulfate-degrading enzyme from human platelets led to the discovery that the enzymatic activity residues in at least two members of the platelet basic protein (PBP) family known as connective tissue activating peptide-III (CTAP-III) and neutrophil activating peptide-2.	Heparitin Sulfate	33-48	pro-platelet basic protein	Homo sapiens	200-203
7852412-2	1995	In this study, purification of a heparan sulfate-degrading enzyme from human platelets led to the discovery that the enzymatic activity residues in at least two members of the platelet basic protein (PBP) family known as connective tissue activating peptide-III (CTAP-III) and neutrophil activating peptide-2.	Heparitin Sulfate	33-48	pro-platelet basic protein	Homo sapiens	221-261
7852412-2	1995	In this study, purification of a heparan sulfate-degrading enzyme from human platelets led to the discovery that the enzymatic activity residues in at least two members of the platelet basic protein (PBP) family known as connective tissue activating peptide-III (CTAP-III) and neutrophil activating peptide-2.	Heparitin Sulfate	33-48	pro-platelet basic protein	Homo sapiens	263-271
7852412-2	1995	In this study, purification of a heparan sulfate-degrading enzyme from human platelets led to the discovery that the enzymatic activity residues in at least two members of the platelet basic protein (PBP) family known as connective tissue activating peptide-III (CTAP-III) and neutrophil activating peptide-2.	Heparitin Sulfate	33-48	pro-platelet basic protein	Homo sapiens	277-308
7744600-5	1995	The role of membrane-associated heparan sulfate in thrombin conversion to an adhesive protein was demonstrated by using CHO cell mutants defective in various aspects of glycosaminoglycan synthesis.	Heparitin Sulfate	32-47	coagulation factor II	Mus musculus	51-59
7532176-2	1995	In the present study we show that COS cell transfectants expressing CD44 isoforms containing the alternatively spliced exon V3 are modified with heparan sulfate (HS).	Heparitin Sulfate	145-160	CD44 molecule (Indian blood group)	Homo sapiens	68-72
7532176-2	1995	In the present study we show that COS cell transfectants expressing CD44 isoforms containing the alternatively spliced exon V3 are modified with heparan sulfate (HS).	Heparitin Sulfate	162-164	CD44 molecule (Indian blood group)	Homo sapiens	68-72
7840621-2	1995	In this paper we examined the potential role of heparan sulfate in the regulation of the action of basic fibroblast growth factor (bFGF) in the terminal differentiation of rat growth plate chondrocytes.	Heparitin Sulfate	48-63	fibroblast growth factor 2	Rattus norvegicus	99-129
7840621-2	1995	In this paper we examined the potential role of heparan sulfate in the regulation of the action of basic fibroblast growth factor (bFGF) in the terminal differentiation of rat growth plate chondrocytes.	Heparitin Sulfate	48-63	fibroblast growth factor 2	Rattus norvegicus	131-135
7840621-10	1995	These results provide evidence that a cell surface heparan sulfate is involved in the binding of bFGF to high-affinity receptors and that a downregulation of this glycosaminoglycan is part of the pathway that leads to terminal differentiation of growth plate chondrocytes.	Heparitin Sulfate	51-66	fibroblast growth factor 2	Rattus norvegicus	97-101
7750519-3	1995	bFGF-HRP association to adult bovine aortic endothelial (ABAE) cells or baby hamster kidney (BHK) cells was inhibited by a high molar excess of native bFGF, a 2 M NaCl wash at neutral pH, heparin and heparan sulfate, but not by chondroitin 4-sulfate or chondroitin 6-sulfate.	Heparitin Sulfate	200-215	fibroblast growth factor 2	Bos taurus	0-4
7662318-7	1995	Heparan sulphate proteoglycan purified from alveolar macrophages bound strongly to immobilized rTf, thus raising the possibility that the low-affinity interaction of transferrin with these cells may be mediated, at least in part, by this glycosaminoglycan.	Heparitin Sulfate	0-16	transferrin	Rattus norvegicus	166-177
7867507-12	1995	Both MK and HB-GAM bound syndecan-1 in solid-phase assays in a heparan sulfate-dependent manner.	Heparitin Sulfate	63-78	midkine	Mus musculus	5-7
7867507-12	1995	Both MK and HB-GAM bound syndecan-1 in solid-phase assays in a heparan sulfate-dependent manner.	Heparitin Sulfate	63-78	pleiotrophin	Mus musculus	12-18
7867507-12	1995	Both MK and HB-GAM bound syndecan-1 in solid-phase assays in a heparan sulfate-dependent manner.	Heparitin Sulfate	63-78	syndecan 1	Mus musculus	25-35
8680403-2	1995	These mutations lead to a deficiency of the glycosidase alpha-L-iduronidase (IDUA), which is required for the degradation of heparan sulphate and dermatan sulphate and thus the storage of these glycosaminoglycans in the lysosome.	Heparitin Sulfate	125-141	alpha-L-iduronidase	Homo sapiens	56-75
8746075-6	1995	The failure of the stem cells to differentiate completely to myoepithelial cells in carcinomas greatly reduces the heparan sulphate proteoglycan sink used to sequester to bFGF in normal glands and also removes the possibility of eliminating cells by terminal differentiation, both processes possibly contributing to the uncontrolled growth of the malignant breast cell.	Heparitin Sulfate	115-131	fibroblast growth factor 2	Homo sapiens	171-175
8680403-2	1995	These mutations lead to a deficiency of the glycosidase alpha-L-iduronidase (IDUA), which is required for the degradation of heparan sulphate and dermatan sulphate and thus the storage of these glycosaminoglycans in the lysosome.	Heparitin Sulfate	125-141	alpha-L-iduronidase	Homo sapiens	77-81
8817695-6	1995	In addition, exogeneously added soluble heparin or heparan sulfate inhibited the binding of IGFBP-3 to the cell surface in a dose-dependent manner.	Heparitin Sulfate	51-66	insulin like growth factor binding protein 3	Homo sapiens	92-99
8569954-7	1995	Heparan sulfate significantly increased type V collagen and laminin in the cellular material and significantly increased laminin and fibronectin in the supernatant material.	Heparitin Sulfate	0-15	fibronectin 1	Rattus norvegicus	133-144
7823125-10	1995	However, the neurite outgrowth-promoting effect of AChE was strictly dependent upon the presence of substratum-bound heparan sulfate proteoglycans (HSPG).	Heparitin Sulfate	117-132	acetylcholinesterase (Cartwright blood group)	Gallus gallus	51-55
7823125-10	1995	However, the neurite outgrowth-promoting effect of AChE was strictly dependent upon the presence of substratum-bound heparan sulfate proteoglycans (HSPG).	Heparitin Sulfate	117-132	heparan sulfate proteoglycan 2	Gallus gallus	148-152
8817695-7	1995	However, when heparin and heparan sulfate linkages of glycosaminoglycans on the cell surface were enzymatically remove, IGFBP-3 binding was only minimally affected.	Heparitin Sulfate	26-41	insulin like growth factor binding protein 3	Homo sapiens	120-127
8817695-8	1995	These data suggest that soluble heparin or heparan sulfate forms a complex with IGFBP-3, thereby inhibiting receptor binding of IGFBP-3, rather than competing with cell-surface glycosaminoglycans for binding of IGFBP-3.	Heparitin Sulfate	43-58	insulin like growth factor binding protein 3	Homo sapiens	80-87
8817695-8	1995	These data suggest that soluble heparin or heparan sulfate forms a complex with IGFBP-3, thereby inhibiting receptor binding of IGFBP-3, rather than competing with cell-surface glycosaminoglycans for binding of IGFBP-3.	Heparitin Sulfate	43-58	insulin like growth factor binding protein 3	Homo sapiens	128-135
8817695-8	1995	These data suggest that soluble heparin or heparan sulfate forms a complex with IGFBP-3, thereby inhibiting receptor binding of IGFBP-3, rather than competing with cell-surface glycosaminoglycans for binding of IGFBP-3.	Heparitin Sulfate	43-58	insulin like growth factor binding protein 3	Homo sapiens	128-135
7528211-0	1994	Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and acidic fibroblast growth factor to the KGF receptor.	Heparitin Sulfate	39-55	fibroblast growth factor 7	Rattus norvegicus	102-105
8548124-0	1995	Basic fibroblast growth factor-heparan sulphate complex in the human dialysis-related amyloidosis.	Heparitin Sulfate	31-47	fibroblast growth factor 2	Homo sapiens	0-30
7528211-17	1994	Binding competition experiments suggest that aFGF and KGF bind to the same population of cell-associated heparan sulfates.	Heparitin Sulfate	105-121	fibroblast growth factor 1	Rattus norvegicus	45-49
7528211-0	1994	Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and acidic fibroblast growth factor to the KGF receptor.	Heparitin Sulfate	39-55	fibroblast growth factor 1	Rattus norvegicus	111-142
7528211-17	1994	Binding competition experiments suggest that aFGF and KGF bind to the same population of cell-associated heparan sulfates.	Heparitin Sulfate	105-121	fibroblast growth factor 7	Rattus norvegicus	54-57
7528211-0	1994	Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and acidic fibroblast growth factor to the KGF receptor.	Heparitin Sulfate	39-55	fibroblast growth factor 7	Rattus norvegicus	150-153
7528211-18	1994	In addition, KGF is apparently interacting with an as yet unidentified type of low affinity binding site that is not affected by chlorate or heparan sulfate-degrading enzymes.	Heparitin Sulfate	141-156	fibroblast growth factor 7	Rattus norvegicus	13-16
7528211-20	1994	Based on the differential effect of cell-associated heparan sulfates on the binding of KGF and aFGF to the KGFR, we propose a regulatory role for cell-associated heparan sulfates as coordinators of the interaction of aFGF and KGF with the KGFR.	Heparitin Sulfate	52-68	fibroblast growth factor 7	Rattus norvegicus	87-90
7528211-8	1994	To gain an insight into the mechanism by which heparin modulates the biological activity of aFGF and KGF, we studied the effect of heparin and cell-associated heparan sulfates on the binding of these two growth factors to the KGFR.	Heparitin Sulfate	159-175	fibroblast growth factor receptor 2	Mus musculus	226-230
7528211-20	1994	Based on the differential effect of cell-associated heparan sulfates on the binding of KGF and aFGF to the KGFR, we propose a regulatory role for cell-associated heparan sulfates as coordinators of the interaction of aFGF and KGF with the KGFR.	Heparitin Sulfate	52-68	fibroblast growth factor 1	Rattus norvegicus	95-99
7528211-20	1994	Based on the differential effect of cell-associated heparan sulfates on the binding of KGF and aFGF to the KGFR, we propose a regulatory role for cell-associated heparan sulfates as coordinators of the interaction of aFGF and KGF with the KGFR.	Heparitin Sulfate	52-68	fibroblast growth factor receptor 2	Mus musculus	107-111
7527332-6	1994	Heparin and heparan sulfate inhibited IGFBP-5 degradation at concentrations of 1 or 2.5 micrograms/ml, but 100 micrograms/ml dermatan sulfate were required.	Heparitin Sulfate	12-27	insulin like growth factor binding protein 5	Homo sapiens	38-45
7528211-20	1994	Based on the differential effect of cell-associated heparan sulfates on the binding of KGF and aFGF to the KGFR, we propose a regulatory role for cell-associated heparan sulfates as coordinators of the interaction of aFGF and KGF with the KGFR.	Heparitin Sulfate	52-68	fibroblast growth factor 1	Rattus norvegicus	217-221
7528211-20	1994	Based on the differential effect of cell-associated heparan sulfates on the binding of KGF and aFGF to the KGFR, we propose a regulatory role for cell-associated heparan sulfates as coordinators of the interaction of aFGF and KGF with the KGFR.	Heparitin Sulfate	52-68	fibroblast growth factor 7	Rattus norvegicus	107-110
7528211-20	1994	Based on the differential effect of cell-associated heparan sulfates on the binding of KGF and aFGF to the KGFR, we propose a regulatory role for cell-associated heparan sulfates as coordinators of the interaction of aFGF and KGF with the KGFR.	Heparitin Sulfate	162-178	fibroblast growth factor 7	Rattus norvegicus	87-90
7528211-20	1994	Based on the differential effect of cell-associated heparan sulfates on the binding of KGF and aFGF to the KGFR, we propose a regulatory role for cell-associated heparan sulfates as coordinators of the interaction of aFGF and KGF with the KGFR.	Heparitin Sulfate	162-178	fibroblast growth factor 1	Rattus norvegicus	95-99
7528211-20	1994	Based on the differential effect of cell-associated heparan sulfates on the binding of KGF and aFGF to the KGFR, we propose a regulatory role for cell-associated heparan sulfates as coordinators of the interaction of aFGF and KGF with the KGFR.	Heparitin Sulfate	162-178	fibroblast growth factor receptor 2	Mus musculus	107-111
7528211-20	1994	Based on the differential effect of cell-associated heparan sulfates on the binding of KGF and aFGF to the KGFR, we propose a regulatory role for cell-associated heparan sulfates as coordinators of the interaction of aFGF and KGF with the KGFR.	Heparitin Sulfate	162-178	fibroblast growth factor 1	Rattus norvegicus	217-221
7528211-20	1994	Based on the differential effect of cell-associated heparan sulfates on the binding of KGF and aFGF to the KGFR, we propose a regulatory role for cell-associated heparan sulfates as coordinators of the interaction of aFGF and KGF with the KGFR.	Heparitin Sulfate	162-178	fibroblast growth factor 7	Rattus norvegicus	107-110
7528211-20	1994	Based on the differential effect of cell-associated heparan sulfates on the binding of KGF and aFGF to the KGFR, we propose a regulatory role for cell-associated heparan sulfates as coordinators of the interaction of aFGF and KGF with the KGFR.	Heparitin Sulfate	162-178	fibroblast growth factor receptor 2	Mus musculus	239-243
7705307-4	1994	One detrimental action of proteases released by adherent neutrophils may be the degradation of extracellular superoxide dismutase (ECSOD), which normally binds to the heparan sulfate on the surface the endothelium.	Heparitin Sulfate	167-182	superoxide dismutase 3	Homo sapiens	95-129
7705307-4	1994	One detrimental action of proteases released by adherent neutrophils may be the degradation of extracellular superoxide dismutase (ECSOD), which normally binds to the heparan sulfate on the surface the endothelium.	Heparitin Sulfate	167-182	superoxide dismutase 3	Homo sapiens	131-136
7527332-4	1994	The addition of heparin, heparan sulfate, and dermatan sulfate (100 micrograms/ml) to the medium of fibroblast monolayer cultures inhibited IGFBP-5 degradation, as determined by the conversion of intact IGFBP-5 to a 23-kilodalton fragment.	Heparitin Sulfate	25-40	insulin like growth factor binding protein 5	Homo sapiens	140-147
7527332-4	1994	The addition of heparin, heparan sulfate, and dermatan sulfate (100 micrograms/ml) to the medium of fibroblast monolayer cultures inhibited IGFBP-5 degradation, as determined by the conversion of intact IGFBP-5 to a 23-kilodalton fragment.	Heparitin Sulfate	25-40	insulin like growth factor binding protein 5	Homo sapiens	203-210
7947934-0	1994	Heparin and heparan sulfate enhancement of the inhibitory activity of plasminogen activator inhibitor type 1 toward urokinase type plasminogen activator.	Heparitin Sulfate	12-27	serpin family E member 1	Homo sapiens	70-108
7853703-4	1994	LPL is believed to be taken on a functionally active form at the site of capillary endothelial cell surface following a series of three major processes: (1) the synthesis and secretion of LPL by adipocytes, (2) the transport of LPL from adipocytes to the capillary endothelium, and (3) the binding of LPL to heparan sulfate proteoglycan chains which are localized in the plasma membrane of the endothelium.	Heparitin Sulfate	308-323	lipoprotein lipase	Homo sapiens	0-3
7998955-1	1994	Mucopolysaccharidosis type I (MPS I, Hurler and Scheie syndromes) is an autosomal recessive lysosomal storage disorder that results from a deficiency of the hydrolase alpha-L-iduronidase (IDUA) which is involved in the lysosomal degradation of both heparan sulphate (HS) and dermatan sulphate (DS).	Heparitin Sulfate	249-265	alpha-L-iduronidase	Homo sapiens	167-186
7998955-1	1994	Mucopolysaccharidosis type I (MPS I, Hurler and Scheie syndromes) is an autosomal recessive lysosomal storage disorder that results from a deficiency of the hydrolase alpha-L-iduronidase (IDUA) which is involved in the lysosomal degradation of both heparan sulphate (HS) and dermatan sulphate (DS).	Heparitin Sulfate	249-265	alpha-L-iduronidase	Homo sapiens	188-192
7998955-1	1994	Mucopolysaccharidosis type I (MPS I, Hurler and Scheie syndromes) is an autosomal recessive lysosomal storage disorder that results from a deficiency of the hydrolase alpha-L-iduronidase (IDUA) which is involved in the lysosomal degradation of both heparan sulphate (HS) and dermatan sulphate (DS).	Heparitin Sulfate	267-269	alpha-L-iduronidase	Homo sapiens	167-186
7998955-1	1994	Mucopolysaccharidosis type I (MPS I, Hurler and Scheie syndromes) is an autosomal recessive lysosomal storage disorder that results from a deficiency of the hydrolase alpha-L-iduronidase (IDUA) which is involved in the lysosomal degradation of both heparan sulphate (HS) and dermatan sulphate (DS).	Heparitin Sulfate	267-269	alpha-L-iduronidase	Homo sapiens	188-192
7947934-0	1994	Heparin and heparan sulfate enhancement of the inhibitory activity of plasminogen activator inhibitor type 1 toward urokinase type plasminogen activator.	Heparitin Sulfate	12-27	plasminogen activator, urokinase	Homo sapiens	116-152
7947946-3	1994	Addition of bovine serum albumin, together with a specific NaCl concentration and pH, results in a specific decrease of heparan sulfate-based absorbance.	Heparitin Sulfate	120-135	albumin	Homo sapiens	19-32
7929459-5	1994	Both soluble heparin and heparan sulfate inhibited AR-induced mitogenesis in MCF-10A human mammary epithelial cells with an IC50 of 5 and 2 micrograms/ml, respectively, whereas soluble chondroitin sulfate had only a slight inhibitory effect.	Heparitin Sulfate	25-40	amphiregulin	Homo sapiens	51-53
7979371-6	1994	Heparin sulfate suppressed endothelin-1 production to a similar level as heparin.	Heparitin Sulfate	0-15	endothelin 1	Homo sapiens	27-39
7957665-6	1994	A hypothesis is advanced to suggest that when transferrin is bound to a component of macrophage plasmalemma, thought to be the glycosaminoglycan of heparan sulfate, its conformation may change in such a way that it attracts other proteins.	Heparitin Sulfate	148-163	transferrin	Rattus norvegicus	46-57
7957667-1	1994	Syndecan-1, a cell surface proteoglycan, binds many extracellular matrix components via its heparan sulfate side chains.	Heparitin Sulfate	92-107	syndecan 1	Mus musculus	0-10
7957667-7	1994	NIH-3T3-derived syndecan contained more chondroitin sulfate than NMuMG-derived syndecan-1, and our results revealed that both heparan sulfate and chondroitin sulfate mediate syndecan-1 binding to laminin.	Heparitin Sulfate	126-141	syndecan 1	Mus musculus	174-184
7699017-0	1994	Heparan sulfate proteoglycans as transducers of FGF-2 signalling.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	48-53
7929434-2	1994	The D-glucuronyl C-5 epimerase involved in the biosynthesis of heparin/heparan sulfate was purified from the high speed supernatant fraction of a homogenate of bovine liver by chromatography on immobilized O-desulfated heparin, red Sepharose, phenyl Sepharose, and concanavalin A-Sepharose.	Heparitin Sulfate	71-86	glucuronic acid epimerase	Bos taurus	4-30
7972011-4	1994	In contrast, heparin sulfate inhibited endothelial cell adhesion to EDA.	Heparitin Sulfate	13-28	ectodysplasin A	Homo sapiens	68-71
7929459-0	1994	Heparan sulfate is essential to amphiregulin-induced mitogenic signaling by the epidermal growth factor receptor.	Heparitin Sulfate	0-15	amphiregulin	Homo sapiens	32-44
7929459-0	1994	Heparan sulfate is essential to amphiregulin-induced mitogenic signaling by the epidermal growth factor receptor.	Heparitin Sulfate	0-15	epidermal growth factor receptor	Homo sapiens	80-112
7523154-3	1994	Indeed, the adhesion of tumor cells to human endothelial cells and heparan sulfate in vitro was inhibited by monoclonal antibodies able to bind and inactivate N-CAM and was abrogated by endothelial cell treatment with heparitinase.	Heparitin Sulfate	67-82	neural cell adhesion molecule 1	Homo sapiens	159-164
7834363-8	1994	The bFGF-mediated acceleration of axonal branch formation was blocked by treatment with heparitinase and by tyrosine inhibitors, herbimycin A and lavendustin A, indicating the importance of heparan sulfate and tyrosine kinase in bFGF signal transduction.	Heparitin Sulfate	190-205	fibroblast growth factor 2	Rattus norvegicus	4-8
7532447-4	1994	Antithrombin, which does not inhibit APC but which does bind to heparin/heparan sulphate with higher affinity than PCI, caused only a small decrease in the inhibition rate of PCI-APC in the presence of unfractionated heparin.	Heparitin Sulfate	72-88	serpin family C member 1	Homo sapiens	0-12
7523154-4	1994	Furthermore, when the renal epithelial cell line COS7 was transfected with a cDNA coding for N-CAM a significant increase in the ability to bind both endothelium and heparan sulfate in vitro was observed.	Heparitin Sulfate	166-181	neural cell adhesion molecule 1	Homo sapiens	93-98
7523154-7	1994	N-CAM was detectable in vivo at the tumor site in the areas of active proliferation, as judged by the coexpression of Ki67 nuclear antigen, and heparan sulfate was present in the wall of blood vessels in the proximity of the tumor.	Heparitin Sulfate	144-159	neural cell adhesion molecule 1	Homo sapiens	0-5
7899141-0	1994	Interferon-gamma, an anti-fibrogenic cytokine which binds to heparan sulfate.	Heparitin Sulfate	61-76	interferon gamma	Homo sapiens	0-16
7967508-0	1994	Basic fibroblast growth factor-binding domain of heparan sulfate in the human glomerulosclerosis and renal tubulointerstitial fibrosis.	Heparitin Sulfate	49-64	fibroblast growth factor 2	Homo sapiens	0-30
7899141-4	1994	In vivo, it is postulated that the heparan sulfate/IFN-gamma interaction can modulate the activity and availability of the cytokine.	Heparitin Sulfate	35-50	interferon gamma	Homo sapiens	51-60
7831680-6	1994	Whereas in the concentration range used (0.3-40 micrograms/ml) these glycosaminoglycans did not inhibit thrombin and factor Xa generation, after supplementation of the system with TFPI a concentration-dependent inhibition of the generation of the proteases up to 40-50% was seen for UFH, LMWH and HS.	Heparitin Sulfate	297-299	tissue factor pathway inhibitor	Homo sapiens	180-184
7818994-4	1994	Urinary CS and HS in CNF did not differ significantly from controls.	Heparitin Sulfate	15-17	NPHS1 adhesion molecule, nephrin	Homo sapiens	21-24
8089154-8	1994	Over 96% of the total adipocyte heparan sulfate chains bound to LPL Affi-Prep 10 column.	Heparitin Sulfate	32-47	lipoprotein lipase	Homo sapiens	64-67
7522446-1	1994	The binding of the 165 amino-acid form of vascular endothelial growth factor (VEGF165) to the VEGF receptors of vascular endothelial cells was potentiated by heparin and heparan-sulfate, but not by other glycosaminoglycans.	Heparitin Sulfate	170-185	vascular endothelial growth factor A	Homo sapiens	42-76
7522446-1	1994	The binding of the 165 amino-acid form of vascular endothelial growth factor (VEGF165) to the VEGF receptors of vascular endothelial cells was potentiated by heparin and heparan-sulfate, but not by other glycosaminoglycans.	Heparitin Sulfate	170-185	vascular endothelial growth factor A	Homo sapiens	78-82
7818994-1	1994	The heparan sulphate proteoglycan (HSPG) of the glomerular basement membrane (GBM) is considered to be mainly responsible for the charge selectivity of the GBM; decreased HSPG results in a decreased anionic charge of the GBM with increased heparan sulphate (HS) in the urine and is believed to be responsible for the proteinuria of the congenital nephrotic syndromes (CNS).	Heparitin Sulfate	4-20	glypican 3	Homo sapiens	35-39
7818994-1	1994	The heparan sulphate proteoglycan (HSPG) of the glomerular basement membrane (GBM) is considered to be mainly responsible for the charge selectivity of the GBM; decreased HSPG results in a decreased anionic charge of the GBM with increased heparan sulphate (HS) in the urine and is believed to be responsible for the proteinuria of the congenital nephrotic syndromes (CNS).	Heparitin Sulfate	4-20	glypican 3	Homo sapiens	171-175
7818994-1	1994	The heparan sulphate proteoglycan (HSPG) of the glomerular basement membrane (GBM) is considered to be mainly responsible for the charge selectivity of the GBM; decreased HSPG results in a decreased anionic charge of the GBM with increased heparan sulphate (HS) in the urine and is believed to be responsible for the proteinuria of the congenital nephrotic syndromes (CNS).	Heparitin Sulfate	35-37	glypican 3	Homo sapiens	4-33
7818994-1	1994	The heparan sulphate proteoglycan (HSPG) of the glomerular basement membrane (GBM) is considered to be mainly responsible for the charge selectivity of the GBM; decreased HSPG results in a decreased anionic charge of the GBM with increased heparan sulphate (HS) in the urine and is believed to be responsible for the proteinuria of the congenital nephrotic syndromes (CNS).	Heparitin Sulfate	35-37	glypican 3	Homo sapiens	171-175
7787797-8	1994	We showed that GM-CSF was produced by, and remained bound to the cell layer through heparan sulfate; this growth factor could be released by high-salt treatment in a biologically active form from both cell types.	Heparitin Sulfate	84-99	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	15-21
7787797-11	1994	These results indicate that the ability of connective tissue cells to sustain myelopoiesis depends directly upon the capacity of their heparan sulfate-bearing molecules to bind and present the GM-CSF to the target cells in a biologically active form.	Heparitin Sulfate	135-150	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	193-199
7811421-13	1994	We noted differences in heparan sulfate"s chemical properties and affinity to antithrombin III in ozone-exposed animals and control animals.	Heparitin Sulfate	24-39	serpin family C member 1	Rattus norvegicus	78-94
7519608-0	1994	Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes.	Heparitin Sulfate	9-24	insulin like growth factor 1	Homo sapiens	73-101
7995378-8	1994	Heparan sulfate, observed to be a constituent of normal elastin fibers, was much reduced in amount.	Heparitin Sulfate	0-15	elastin	Homo sapiens	56-63
7999366-1	1994	Fibroblast growth factors (FGFs) are a family of nine proteins that bind to three distinct types of cell surface molecules: (i) FGF receptor tyrosine kinases (FGFR-1 through FGFR-4); (ii) a cysteine-rich FGF receptor (CFR); and (iii) heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	234-249	fibroblast growth factor 10	Gallus gallus	27-30
7999366-3	1994	The length and sulfation pattern of the heparan sulfate chain determines both the activity of the signaling complex and, in part, the ligand specificity for FGFR-1.	Heparitin Sulfate	40-55	fibroblast growth factor receptor 1	Gallus gallus	157-163
8043862-0	1994	Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate.	Heparitin Sulfate	135-150	integrin beta 2	Mus musculus	13-17
8043862-0	1994	Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate.	Heparitin Sulfate	135-150	protein tyrosine phosphatase, receptor type, C	Mus musculus	23-27
8043862-11	1994	The data suggest that heparan sulfate on the 3T3 cell surface is a ligand for both CD45 and Mac-1, but the two molecules recognize different heparan sulfate structural motifs.	Heparitin Sulfate	22-37	protein tyrosine phosphatase, receptor type, C	Mus musculus	83-87
8043862-11	1994	The data suggest that heparan sulfate on the 3T3 cell surface is a ligand for both CD45 and Mac-1, but the two molecules recognize different heparan sulfate structural motifs.	Heparitin Sulfate	22-37	integrin alpha M	Mus musculus	92-97
8050494-2	1994	Heparinase II treatment of HeLa and CCL 39 cells resulted in a decrease of bFGF binding by 96 and 57%, respectively, indicating that heparan sulfate molecules were involved in bFGF binding.	Heparitin Sulfate	133-148	fibroblast growth factor 2	Homo sapiens	75-79
8050494-2	1994	Heparinase II treatment of HeLa and CCL 39 cells resulted in a decrease of bFGF binding by 96 and 57%, respectively, indicating that heparan sulfate molecules were involved in bFGF binding.	Heparitin Sulfate	133-148	fibroblast growth factor 2	Homo sapiens	176-180
8043862-0	1994	Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate.	Heparitin Sulfate	135-150	integrin alpha M	Mus musculus	0-5
8043862-0	1994	Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate.	Heparitin Sulfate	135-150	integrin alpha M	Mus musculus	7-12
7827407-1	1994	The biological activity of basic fibroblast growth factor (bFGF) is influenced greatly by direct binding to heparin and heparan sulphate (HS).	Heparitin Sulfate	120-136	fibroblast growth factor 2	Homo sapiens	27-57
7827407-1	1994	The biological activity of basic fibroblast growth factor (bFGF) is influenced greatly by direct binding to heparin and heparan sulphate (HS).	Heparitin Sulfate	120-136	fibroblast growth factor 2	Homo sapiens	59-63
8034644-0	1994	Cell surface syndecan-1 on distinct cell types differs in fine structure and ligand binding of its heparan sulfate chains.	Heparitin Sulfate	99-114	syndecan 1	Mus musculus	13-23
7827407-1	1994	The biological activity of basic fibroblast growth factor (bFGF) is influenced greatly by direct binding to heparin and heparan sulphate (HS).	Heparitin Sulfate	138-140	fibroblast growth factor 2	Homo sapiens	27-57
7827407-1	1994	The biological activity of basic fibroblast growth factor (bFGF) is influenced greatly by direct binding to heparin and heparan sulphate (HS).	Heparitin Sulfate	138-140	fibroblast growth factor 2	Homo sapiens	59-63
7827407-3	1994	We had previously demonstrated that fragments &gt; 6 mer can inhibit the interaction between cell surface heparan sulphate proteoglycan (HSPG) and bFGF, and bFGF-induced proliferation of adrenocortical endothelial (ACE) cells.	Heparitin Sulfate	106-122	syndecan 2	Homo sapiens	137-141
7827407-3	1994	We had previously demonstrated that fragments &gt; 6 mer can inhibit the interaction between cell surface heparan sulphate proteoglycan (HSPG) and bFGF, and bFGF-induced proliferation of adrenocortical endothelial (ACE) cells.	Heparitin Sulfate	106-122	fibroblast growth factor 2	Homo sapiens	147-151
7827407-3	1994	We had previously demonstrated that fragments &gt; 6 mer can inhibit the interaction between cell surface heparan sulphate proteoglycan (HSPG) and bFGF, and bFGF-induced proliferation of adrenocortical endothelial (ACE) cells.	Heparitin Sulfate	106-122	fibroblast growth factor 2	Homo sapiens	157-161
8034692-8	1994	More importantly, introducing tryptophan next to three different Ser-Gly dipeptides in betaglycan and syndecan-1 chimeras stimulated assembly of heparan sulfate.	Heparitin Sulfate	145-160	syndecan-1	Cricetulus griseus	102-112
7974391-10	1994	A number of different glycosaminoglycans were tested and the following order of TFPI affinity was found: heparin &gt;&gt; dermatan sulphate &gt; heparan sulphate &gt; chondroitin sulphate C.	Heparitin Sulfate	145-161	tissue factor pathway inhibitor	Homo sapiens	80-84
8182050-8	1994	Heparan sulfate, chondroitin sulfate, and dermatan sulfate, three glycosaminoglycans structurally related to heparin, were &gt; or = 80-fold less effective in binding to RMCP-1 than heparin.	Heparitin Sulfate	0-15	mast cell protease 1-like 1	Rattus norvegicus	170-176
8068301-0	1994	Calcium-enhanced aggregation of serum amyloid P component and its inhibition by the ligands heparin and heparan sulphate.	Heparitin Sulfate	104-120	amyloid P component, serum	Homo sapiens	32-57
8068301-13	1994	Binding of the ligands heparin and heparan sulphate to SAP completely abolished the calcium-enhanced aggregation, but the distribution of the SAP molecules was affected, resulting in strands or groups of adjacent molecules.	Heparitin Sulfate	35-51	amyloid P component, serum	Homo sapiens	55-58
7962199-11	1994	Syndecan-1 could also be released into the Triton X-100-soluble fraction by addition of heparin or heparan sulfate to the extraction medium.	Heparitin Sulfate	99-114	syndecan 1	Mus musculus	0-10
7962199-13	1994	Instead, our results indicate that Triton X-100 insolubility is caused by an interaction of syndecan-1 molecules with other cellular and/or extracellular molecules mediated by the heparan sulfate chains.	Heparitin Sulfate	180-195	syndecan 1	Mus musculus	92-102
8193348-5	1994	The exogeneous addition of heparan sulfate, which has strong affinity for bFGF, efficiently inhibited the binding between PG-M-CSF and bFGF.	Heparitin Sulfate	27-42	fibroblast growth factor 2	Mus musculus	74-78
8193348-5	1994	The exogeneous addition of heparan sulfate, which has strong affinity for bFGF, efficiently inhibited the binding between PG-M-CSF and bFGF.	Heparitin Sulfate	27-42	fibroblast growth factor 2	Mus musculus	122-139
8193348-6	1994	These results show that PG-M-CSF binds bFGF through its carboxyl terminal peptide and that the binding sites for PG-M-CSF and heparan sulfate on bFGF are located close together.	Heparitin Sulfate	126-141	colony stimulating factor 1 (macrophage)	Mus musculus	27-32
8193348-6	1994	These results show that PG-M-CSF binds bFGF through its carboxyl terminal peptide and that the binding sites for PG-M-CSF and heparan sulfate on bFGF are located close together.	Heparitin Sulfate	126-141	fibroblast growth factor 2	Mus musculus	39-43
8193348-6	1994	These results show that PG-M-CSF binds bFGF through its carboxyl terminal peptide and that the binding sites for PG-M-CSF and heparan sulfate on bFGF are located close together.	Heparitin Sulfate	126-141	fibroblast growth factor 2	Mus musculus	145-149
7949658-6	1994	Sci, USA, 88, 2768-2772, 1991) to study the binding of the heparan sulphate proteoglycan syndecan-1 and heparin to human collagens.	Heparitin Sulfate	59-75	syndecan 1	Homo sapiens	89-99
8175735-4	1994	Affinity co-electrophoresis reveals that intact syndecan-1 isolated from P3 cells binds collagen poorly and that syndecan-1 heparan sulfate isolated from MPC-11 has a 20-fold higher affinity for collagen than syndecan-1 heparan sulfate from P3.	Heparitin Sulfate	124-139	syndecan 1	Mus musculus	113-123
8175735-4	1994	Affinity co-electrophoresis reveals that intact syndecan-1 isolated from P3 cells binds collagen poorly and that syndecan-1 heparan sulfate isolated from MPC-11 has a 20-fold higher affinity for collagen than syndecan-1 heparan sulfate from P3.	Heparitin Sulfate	124-139	syndecan 1	Mus musculus	113-123
8175735-0	1994	Fine structure of heparan sulfate regulates syndecan-1 function and cell behavior.	Heparitin Sulfate	18-33	syndecan 1	Mus musculus	44-54
8175735-4	1994	Affinity co-electrophoresis reveals that intact syndecan-1 isolated from P3 cells binds collagen poorly and that syndecan-1 heparan sulfate isolated from MPC-11 has a 20-fold higher affinity for collagen than syndecan-1 heparan sulfate from P3.	Heparitin Sulfate	220-235	syndecan 1	Mus musculus	113-123
8175735-2	1994	The syndecan-1 molecules from both lines are similar in size, have indistinguishable core proteins, and have similarly sized heparan sulfate chains.	Heparitin Sulfate	125-140	syndecan 1	Mus musculus	4-14
8175774-1	1994	Rat hepatoma McA-RH7777 cells transfected with a human hepatic lipase (HL) cDNA synthesized and secreted 50-80 ng of human HL/mg of cell protein at 4 h, approximately 50% of which was bound to cell-surface heparan sulfate proteoglycans (HSPG).	Heparitin Sulfate	206-221	lipase C, hepatic type	Homo sapiens	55-69
8175735-4	1994	Affinity co-electrophoresis reveals that intact syndecan-1 isolated from P3 cells binds collagen poorly and that syndecan-1 heparan sulfate isolated from MPC-11 has a 20-fold higher affinity for collagen than syndecan-1 heparan sulfate from P3.	Heparitin Sulfate	220-235	syndecan 1	Mus musculus	113-123
8175735-5	1994	Analysis of disaccharide composition and oligosaccharide mapping also reveals differences between MPC-11 and P3 heparan sulfate.	Heparitin Sulfate	112-127	olfactory receptor family 10 subfamily A member 5	Mus musculus	109-111
8175735-6	1994	Most notably, the level of N-sulfation and 2-O-sulfation is higher, and 6-O-sulfation lower, in syndecan-1 heparan sulfate from MPC-11 than from P3.	Heparitin Sulfate	107-122	syndecan 1	Mus musculus	96-106
8175735-7	1994	Interestingly, levels of total sulfation of syndecan-1 heparan sulfate from MPC-11 and P3 are similar (75.6 and 72.6 sulfates/100 disaccharides, respectively), indicating that the difference in their affinity for collagen is not due to a difference in net charge.	Heparitin Sulfate	55-70	syndecan 1	Mus musculus	44-54
8175739-9	1994	In addition, 50% of the 125I-LDL and 30% of the 125I-LPL were degraded within 3 h. After metabolic labeling of THP-1 proteoglycans with 35SO4, &gt; 30% of pericellular heparan sulfate was lost between 2-4 h of the chase period.	Heparitin Sulfate	168-183	GLI family zinc finger 2	Homo sapiens	111-116
8074477-0	1994	PMA induces shift from chondroitin to heparan sulphate on proteoglycans correlating with fibronectin adhesion of MDS human leukemia cells.	Heparitin Sulfate	38-54	fibronectin 1	Homo sapiens	89-100
8174783-2	1994	Local application of heparan sulfate conjugated beads loaded with fibroblast growth factor-2 (FGF-2) onto an amputated stage 25 chick limb bud results in a high frequency (88%) of limbs in which the regeneration of digit-like structures was induced.	Heparitin Sulfate	21-36	fibroblast growth factor 2	Gallus gallus	66-92
7922353-8	1994	This observation led to predictions about the relative affinities of heparan sulfate for interleukin-8 and platelet factor 4, predictions that were confirmed by further binding assays.	Heparitin Sulfate	69-84	C-X-C motif chemokine ligand 8	Homo sapiens	89-124
8196366-7	1994	CONCLUSIONS: The findings established that EC-SOD C in the tissue interstitium exists almost completely anchored to heparan sulfate proteoglycan via the carboxyterminal heparin-binding domains, and that this binding is the determinant of the long tissue retention of the enzyme.	Heparitin Sulfate	116-131	superoxide dismutase 3	Rattus norvegicus	43-49
8167338-2	1994	Heparan sulfate (HS) is a physiologic endothelial cell surface modulator of normal anticoagulation, containing a specific oligosaccharide sequence that binds antithrombin III with high affinity and also is present in heparin, a related glycosaminoglycan.	Heparitin Sulfate	0-15	serpin family C member 1	Homo sapiens	158-174
8167338-2	1994	Heparan sulfate (HS) is a physiologic endothelial cell surface modulator of normal anticoagulation, containing a specific oligosaccharide sequence that binds antithrombin III with high affinity and also is present in heparin, a related glycosaminoglycan.	Heparitin Sulfate	17-19	serpin family C member 1	Homo sapiens	158-174
8163569-4	1994	Heparan sulfate proteoglycans (HSPG) with Kd values of 0.09, 0.13, and 0.39 were minor components of the cell layer, while a single heparan sulfate (Kd = 0.17) was recovered from the medium.	Heparitin Sulfate	0-15	syndecan 2	Rattus norvegicus	31-35
8174783-2	1994	Local application of heparan sulfate conjugated beads loaded with fibroblast growth factor-2 (FGF-2) onto an amputated stage 25 chick limb bud results in a high frequency (88%) of limbs in which the regeneration of digit-like structures was induced.	Heparitin Sulfate	21-36	fibroblast growth factor 2	Gallus gallus	94-99
8157651-0	1994	Interaction of hepatocyte growth factor with heparan sulfate.	Heparitin Sulfate	45-60	hepatocyte growth factor	Homo sapiens	15-39
8163535-0	1994	Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1.	Heparitin Sulfate	71-86	syndecan 1	Mus musculus	114-124
8157651-2	1994	We have demonstrated by affinity chromatography that hepatocyte growth factor (HGF) binds strongly to heparan sulfate (HS).	Heparitin Sulfate	102-117	hepatocyte growth factor	Homo sapiens	53-77
8157651-2	1994	We have demonstrated by affinity chromatography that hepatocyte growth factor (HGF) binds strongly to heparan sulfate (HS).	Heparitin Sulfate	102-117	hepatocyte growth factor	Homo sapiens	79-82
8161780-3	1994	The bFGF-proteoglycan complex is biologically active and is released by addition of exogenous phosphatidylinositol-specific phospholipase C. In this study, we show the presence of an endogenous GPI-specific phospholipase D (GPI-PLD) that releases the bFGF-binding heparan sulfate proteoglycan and the variant surface glycoprotein (a model GPI-anchored protein) from BM cultures.	Heparitin Sulfate	264-279	fibroblast growth factor 2	Homo sapiens	4-8
8157651-2	1994	We have demonstrated by affinity chromatography that hepatocyte growth factor (HGF) binds strongly to heparan sulfate (HS).	Heparitin Sulfate	119-121	hepatocyte growth factor	Homo sapiens	53-77
8157651-2	1994	We have demonstrated by affinity chromatography that hepatocyte growth factor (HGF) binds strongly to heparan sulfate (HS).	Heparitin Sulfate	119-121	hepatocyte growth factor	Homo sapiens	79-82
8161780-3	1994	The bFGF-proteoglycan complex is biologically active and is released by addition of exogenous phosphatidylinositol-specific phospholipase C. In this study, we show the presence of an endogenous GPI-specific phospholipase D (GPI-PLD) that releases the bFGF-binding heparan sulfate proteoglycan and the variant surface glycoprotein (a model GPI-anchored protein) from BM cultures.	Heparitin Sulfate	264-279	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	194-222
8161203-0	1994	Basic fibroblast growth factor binds to heparan sulfate in the extracellular matrix of rat growth plate chondrocytes.	Heparitin Sulfate	40-55	fibroblast growth factor 2	Rattus norvegicus	0-30
8165708-7	1994	Neutralizing antibodies against IL-1 alpha, but not antibodies against IL1 beta, IL-6, or TNF alpha/beta, abrogate the heparan sulfate-mediated increase in cytotoxicity, suggesting that the increase depended in part upon the production of IL-1 alpha.	Heparitin Sulfate	119-134	interleukin 1 alpha	Homo sapiens	32-42
8165708-7	1994	Neutralizing antibodies against IL-1 alpha, but not antibodies against IL1 beta, IL-6, or TNF alpha/beta, abrogate the heparan sulfate-mediated increase in cytotoxicity, suggesting that the increase depended in part upon the production of IL-1 alpha.	Heparitin Sulfate	119-134	interleukin 1 alpha	Homo sapiens	239-249
8165708-10	1994	Heparan sulfate-treated CD8+ lymphoblasts isolated after 7 days in MLC demonstrated an increased cytotoxicity, elevated intracellular serine esterase, and perforin levels compared with lymphoblasts from control MLC.	Heparitin Sulfate	0-15	CD8a molecule	Homo sapiens	24-27
8142385-2	1994	Previous reports have implicated the binding of heparin, or heparan sulfate, to FGF as essential for FGF-mediated signal transduction and mitogenicity.	Heparitin Sulfate	60-75	fibroblast growth factor 2	Homo sapiens	80-83
8142385-2	1994	Previous reports have implicated the binding of heparin, or heparan sulfate, to FGF as essential for FGF-mediated signal transduction and mitogenicity.	Heparitin Sulfate	60-75	fibroblast growth factor 2	Homo sapiens	101-104
8161203-5	1994	The binding of [125I]bFGF to rat growth plate ECM was inhibited by the addition of heparin, heparan sulfate, and dermatan sulfate.	Heparitin Sulfate	92-107	fibroblast growth factor 2	Rattus norvegicus	21-25
8161203-12	1994	The results demonstrate that bFGF binds to a heparan sulfate in matrix produced by rat growth plate chondrocytes and matrix extracted from rat growth plate and suggest that this glycosaminoglycan may serve as a storage depot for this growth factor during endochondral ossification.	Heparitin Sulfate	45-60	fibroblast growth factor 2	Rattus norvegicus	29-33
7512117-1	1994	The amino acid residues critical for interaction between herpes simplex virus type 1 (HSV-1) glycoprotein C (gC-1) and cell surface heparan sulphate (HS) were localized to two separate regions within antigenic site II of this glycoprotein.	Heparitin Sulfate	132-148	solute carrier family 25 member 22	Homo sapiens	109-113
8176841-7	1994	Although neither net negative charge nor proportion in total glycosaminoglycans of cell surface heparan sulfate was altered by homocysteine treatment, a substantial reduction in antithrombin III binding capacity of heparan sulfate isolated from homocysteine-treated endothelial cells was found using both affinity chromatography and dot blot assay techniques.	Heparitin Sulfate	215-230	serpin family C member 1	Homo sapiens	178-194
7511169-3	1994	Accordingly, we have investigated whether the apparent precursor of protease-resistant PrP, protease-sensitive PrP, binds to Congo red and heparin, a highly sulfated glycosaminoglycan with an inhibitory potency like that of heparan sulfate.	Heparitin Sulfate	224-239	prion protein	Mus musculus	87-90
7511169-3	1994	Accordingly, we have investigated whether the apparent precursor of protease-resistant PrP, protease-sensitive PrP, binds to Congo red and heparin, a highly sulfated glycosaminoglycan with an inhibitory potency like that of heparan sulfate.	Heparitin Sulfate	224-239	prion protein	Mus musculus	111-114
7512117-1	1994	The amino acid residues critical for interaction between herpes simplex virus type 1 (HSV-1) glycoprotein C (gC-1) and cell surface heparan sulphate (HS) were localized to two separate regions within antigenic site II of this glycoprotein.	Heparitin Sulfate	86-88	solute carrier family 25 member 22	Homo sapiens	109-113
8125158-10	1994	Taken together, these results suggest that HGF can be trapped in extracellular matrix, probably through heparan sulfate in vivo, thereby acting as a mitogen for hepatocytes in cooperation with heparan sulfate.	Heparitin Sulfate	104-119	hepatocyte growth factor	Rattus norvegicus	43-46
8125158-10	1994	Taken together, these results suggest that HGF can be trapped in extracellular matrix, probably through heparan sulfate in vivo, thereby acting as a mitogen for hepatocytes in cooperation with heparan sulfate.	Heparitin Sulfate	193-208	hepatocyte growth factor	Rattus norvegicus	43-46
8307953-1	1994	The role of heparin or heparan sulfates in the interaction of basic fibroblast growth factor (bFGF) with its high affinity receptor were investigated using purified extracellular ligand-binding region of FGF receptor-1 (FGFR-1) and intact receptors expressed in a myeloid cell line (32D) that does not express detectable levels of heparan sulfate proteoglycans or in Chinese hamster ovary (CHO) cell mutants defective in heparan sulfate synthesis.	Heparitin Sulfate	23-38	fibroblast growth factor 2	Mus musculus	94-98
8016815-0	1994	Effects of heparan sulfate analogue or other sulfated polysaccharides on the activation of plasminogen by t-PA or u-PA.	Heparitin Sulfate	11-26	plasminogen activator, tissue type	Homo sapiens	106-110
8307953-1	1994	The role of heparin or heparan sulfates in the interaction of basic fibroblast growth factor (bFGF) with its high affinity receptor were investigated using purified extracellular ligand-binding region of FGF receptor-1 (FGFR-1) and intact receptors expressed in a myeloid cell line (32D) that does not express detectable levels of heparan sulfate proteoglycans or in Chinese hamster ovary (CHO) cell mutants defective in heparan sulfate synthesis.	Heparitin Sulfate	331-346	fibroblast growth factor 2	Mus musculus	94-98
8307953-1	1994	The role of heparin or heparan sulfates in the interaction of basic fibroblast growth factor (bFGF) with its high affinity receptor were investigated using purified extracellular ligand-binding region of FGF receptor-1 (FGFR-1) and intact receptors expressed in a myeloid cell line (32D) that does not express detectable levels of heparan sulfate proteoglycans or in Chinese hamster ovary (CHO) cell mutants defective in heparan sulfate synthesis.	Heparitin Sulfate	23-39	fibroblast growth factor 2	Mus musculus	94-98
8307953-7	1994	When FGFR-1 or FGFR-2 were expressed in mutant CHO cells deficient in heparan sulfate synthesis, the cells also bound 125I-bFGF in the absence of heparin, and the addition of heparin increased the affinity of bFGF for its receptors 2-3-fold.	Heparitin Sulfate	70-85	fibroblast growth factor receptor 1	Cricetulus griseus	5-11
8307953-7	1994	When FGFR-1 or FGFR-2 were expressed in mutant CHO cells deficient in heparan sulfate synthesis, the cells also bound 125I-bFGF in the absence of heparin, and the addition of heparin increased the affinity of bFGF for its receptors 2-3-fold.	Heparitin Sulfate	70-85	fibroblast growth factor receptor 2	Cricetulus griseus	15-21
8288646-4	1994	This paper describes further work on the binding properties of HS saccharides and their capacity to mediate bFGF activity in a mitogenesis assay in which responsiveness is dependent on the addition of HS or heparin.	Heparitin Sulfate	63-65	fibroblast growth factor 2	Homo sapiens	108-112
8300582-7	1994	Finally, a synthetic peptide derived from the 21-residue stretch was found to compete with HB-EGF for binding to Chinese hamster ovary cells, suggesting that the heparin-binding sequences in HB-EGF may also mediate the interaction of this factor with cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	264-279	proheparin-binding EGF-like growth factor	Cricetulus griseus	91-97
8300582-7	1994	Finally, a synthetic peptide derived from the 21-residue stretch was found to compete with HB-EGF for binding to Chinese hamster ovary cells, suggesting that the heparin-binding sequences in HB-EGF may also mediate the interaction of this factor with cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	264-279	proheparin-binding EGF-like growth factor	Cricetulus griseus	191-197
8288571-9	1994	Thus, it is likely that the basic clusters in these domains cooperatively contribute to the binding of HGF to the anionic heparin or heparan sulfate molecule.	Heparitin Sulfate	133-148	hepatocyte growth factor	Homo sapiens	103-106
8263027-7	1994	At 2 mM PNP-xyloside, heparan sulfate as well as chondroitin sulfate addition to core proteins was disrupted: the core protein of epican, a heparan sulfate form of CD44 found on keratinocytes, was detected immunologically but lacked heparan sulfate.	Heparitin Sulfate	140-155	CD44 molecule (Indian blood group)	Homo sapiens	130-136
8276871-11	1994	The core protein of chicken syndecan-4 synthesized by chicken cells is modified with heparan sulfate side chains yielding a proteoglycan with a molecular mass of &gt; 200 kDa in LMH cells (immortalized male leghorn LM strain hepatocytes) and primary skin fibroblasts.	Heparitin Sulfate	85-100	syndecan 4	Gallus gallus	28-38
8276782-2	1994	The capacity of various species of heparin and heparan sulfate (HS) to promote bFGF receptor binding was investigated using both Chinese hamster ovary mutant cells deficient in cell surface HSPG and a soluble bFGF receptor-alkaline phosphatase fusion protein.	Heparitin Sulfate	47-62	fibroblast growth factor 2	Bos taurus	79-83
8276782-2	1994	The capacity of various species of heparin and heparan sulfate (HS) to promote bFGF receptor binding was investigated using both Chinese hamster ovary mutant cells deficient in cell surface HSPG and a soluble bFGF receptor-alkaline phosphatase fusion protein.	Heparitin Sulfate	64-66	fibroblast growth factor 2	Bos taurus	79-83
8276782-11	1994	These results suggest the involvement of defined heparin-like oligosaccharide sequences and unique species of cell surface and extracellular matrix HS in the regulation of bFGF receptor binding and biological activity.	Heparitin Sulfate	148-150	fibroblast growth factor 2	Bos taurus	172-176
8311835-3	1994	We report here using Chinese hamster ovary cell mutants bearing deficiency in heparan sulfate proteoglycans (HSPGs) synthesis that HSPGs are required for transport of exogenous FGF-2 to the nucleus.	Heparitin Sulfate	78-93	fibroblast growth factor 2	Cricetulus griseus	177-182
8263027-7	1994	At 2 mM PNP-xyloside, heparan sulfate as well as chondroitin sulfate addition to core proteins was disrupted: the core protein of epican, a heparan sulfate form of CD44 found on keratinocytes, was detected immunologically but lacked heparan sulfate.	Heparitin Sulfate	140-155	CD44 molecule (Indian blood group)	Homo sapiens	164-168
8263027-7	1994	At 2 mM PNP-xyloside, heparan sulfate as well as chondroitin sulfate addition to core proteins was disrupted: the core protein of epican, a heparan sulfate form of CD44 found on keratinocytes, was detected immunologically but lacked heparan sulfate.	Heparitin Sulfate	140-155	CD44 molecule (Indian blood group)	Homo sapiens	130-136
8294498-6	1994	The cerebroglycan core protein has a predicted molecular mass of 58.6 kD and five potential heparan sulfate attachment sites.	Heparitin Sulfate	92-107	glypican 2	Rattus norvegicus	4-17
8263027-7	1994	At 2 mM PNP-xyloside, heparan sulfate as well as chondroitin sulfate addition to core proteins was disrupted: the core protein of epican, a heparan sulfate form of CD44 found on keratinocytes, was detected immunologically but lacked heparan sulfate.	Heparitin Sulfate	140-155	CD44 molecule (Indian blood group)	Homo sapiens	164-168
8245966-1	1993	The senile plaques found within the cerebral cortex and hippocampus of the Alzheimer disease brain contain beta-amyloid peptide (A beta) fibrils that are associated with a variety of macromolecular species, including dermatan sulfate proteoglycan and heparan sulfate proteoglycan.	Heparitin Sulfate	251-266	amyloid beta precursor protein	Homo sapiens	107-127
8263327-1	1994	We raised monoclonal antibodies (MAb) against the core protein and the heparan sulfate (HS) side chain of heparan sulfate proteoglycan (HSPG) from glomerular basement membranes (GBM).	Heparitin Sulfate	71-86	CD44 molecule (Indian blood group)	Homo sapiens	106-134
8263327-1	1994	We raised monoclonal antibodies (MAb) against the core protein and the heparan sulfate (HS) side chain of heparan sulfate proteoglycan (HSPG) from glomerular basement membranes (GBM).	Heparitin Sulfate	71-86	CD44 molecule (Indian blood group)	Homo sapiens	136-140
8263327-1	1994	We raised monoclonal antibodies (MAb) against the core protein and the heparan sulfate (HS) side chain of heparan sulfate proteoglycan (HSPG) from glomerular basement membranes (GBM).	Heparitin Sulfate	88-90	CD44 molecule (Indian blood group)	Homo sapiens	106-134
8263327-1	1994	We raised monoclonal antibodies (MAb) against the core protein and the heparan sulfate (HS) side chain of heparan sulfate proteoglycan (HSPG) from glomerular basement membranes (GBM).	Heparitin Sulfate	88-90	CD44 molecule (Indian blood group)	Homo sapiens	136-140
8281931-5	1993	The release of type-II PLA2 from TNF-stimulated cells was also found in the presence of heparan sulfate or dextran sulfate, whereas other glycosaminoglycans showed no effects under the same conditions.	Heparitin Sulfate	88-103	tumor necrosis factor-like	Rattus norvegicus	33-36
7925491-6	1993	Further characterization of the binding sites showed that both osteosarcoma cells express two different kinds of binding sites: Besides binding to a specific OSF-1 receptor, OSF-1 also significantly binds to cell surface heparan sulfates.	Heparitin Sulfate	221-237	pleiotrophin	Homo sapiens	174-179
8138544-0	1993	Membrane-intercalated proteoglycan of a stroma-inducing clone from Lewis lung carcinoma binds to fibronectin via its heparan sulfate chains.	Heparitin Sulfate	117-132	fibronectin 1	Homo sapiens	97-108
8138544-10	1993	Affinity chromatographies of the CPGIIIB proteoglycan on fibronectin-Sepharose 4B after treatments with these enzymes demonstrated that it bound to fibronectin via its heparan sulfate chains.	Heparitin Sulfate	168-183	fibronectin 1	Homo sapiens	148-159
7530143-11	1994	It will be interesting to see whether the interaction between tenascin and cell surface contactin/F11, and possibly cellular heparan sulfate proteoglycans, contributes to the prominent role played by tenascin in pattern formation during development of the nervous system.	Heparitin Sulfate	125-140	avian tenascin X	Gallus gallus	200-208
8138538-7	1993	In addition to heparin, heparan sulfate also stimulated HGF production, albeit to a lesser extent than heparin; 1.7-fold stimulation with 2 micrograms/ml heparan sulfate.	Heparitin Sulfate	24-39	hepatocyte growth factor	Homo sapiens	56-59
8138538-7	1993	In addition to heparin, heparan sulfate also stimulated HGF production, albeit to a lesser extent than heparin; 1.7-fold stimulation with 2 micrograms/ml heparan sulfate.	Heparitin Sulfate	154-169	hepatocyte growth factor	Homo sapiens	56-59
8245966-4	1993	A beta(1-28) associates with heparin, heparan sulfate, dermatan sulfate, and chondroitin sulfate.	Heparitin Sulfate	38-53	amyloid beta precursor protein	Homo sapiens	0-6
8245966-1	1993	The senile plaques found within the cerebral cortex and hippocampus of the Alzheimer disease brain contain beta-amyloid peptide (A beta) fibrils that are associated with a variety of macromolecular species, including dermatan sulfate proteoglycan and heparan sulfate proteoglycan.	Heparitin Sulfate	251-266	amyloid beta precursor protein	Homo sapiens	129-135
8228255-12	1993	The interaction between heparan sulfate on cell surface and the heparin-binding domain of type II PLA2 may be important for the induction of exocytosis.	Heparitin Sulfate	24-39	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	98-102
8226930-1	1993	Experiments based on interaction in free solution between basic fibroblast growth factor (FGF-2) and saccharides related to heparin/heparan sulfate showed that the growth factor binds to heparin and to selectively glucosaminyl 6-O-desulfated heparin but poorly to iduronosyl 2-O-desulfated heparin.	Heparitin Sulfate	132-147	fibroblast growth factor 2	Homo sapiens	90-95
8274446-8	1993	In addition, treatment of SC-3 cells with sulfation blocker (chlorate) or heparitinase results in the abolishment of their ability to respond to androgen or AIGF, indicating that heparan sulfate has important roles for condensing AIGF on or near the cell surface as well as potentiating the biological activity of AIGF.	Heparitin Sulfate	179-194	fibroblast growth factor 8	Homo sapiens	157-161
8274446-8	1993	In addition, treatment of SC-3 cells with sulfation blocker (chlorate) or heparitinase results in the abolishment of their ability to respond to androgen or AIGF, indicating that heparan sulfate has important roles for condensing AIGF on or near the cell surface as well as potentiating the biological activity of AIGF.	Heparitin Sulfate	179-194	fibroblast growth factor 8	Homo sapiens	230-234
8274446-8	1993	In addition, treatment of SC-3 cells with sulfation blocker (chlorate) or heparitinase results in the abolishment of their ability to respond to androgen or AIGF, indicating that heparan sulfate has important roles for condensing AIGF on or near the cell surface as well as potentiating the biological activity of AIGF.	Heparitin Sulfate	179-194	fibroblast growth factor 8	Homo sapiens	230-234
8226969-2	1993	As a heparan sulfate-containing cell surface molecule, syndecan-1 can simultaneously bind various components of the extracellular matrix and members of the heparin-binding growth factors.	Heparitin Sulfate	5-20	syndecan 1	Mus musculus	55-65
8298962-0	1993	Binding of vascular heparan sulfate proteoglycan to Alzheimer"s amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide.	Heparitin Sulfate	20-35	amyloid beta precursor protein	Homo sapiens	64-89
7693043-10	1993	The high level of expression of PECAM-1 on CD34+ cells suggests that this glycoprotein may function as a heterotypic adhesion molecule, possibly mediating multipotential, myeloid, and early-B-lymphoid precursor cell interactions with stromal cells and extracellular matrix molecules via heparan sulfate proteoglycans.	Heparitin Sulfate	287-302	platelet and endothelial cell adhesion molecule 1	Homo sapiens	32-39
8106273-0	1993	Regulation by heparan sulfate and interleukin 1 alpha of the ontogenic expression of T-cell receptor, CD4, and CD8 in developing thymus.	Heparitin Sulfate	14-29	CD4 antigen	Mus musculus	102-105
8404691-5	1993	Treatment of whole ovarian dispersates with IL-1 beta (10 ng/ml) produced substantial increments in the accumulation of extracellular macromolecular material [11.5-, 2.9- and 2.6-fold for hyaluronic acid (HA), heparan sulfate (HS) and dermatan sulfate (DS) proteoglycans, respectively].	Heparitin Sulfate	210-225	interleukin 1 beta	Rattus norvegicus	44-53
8404691-5	1993	Treatment of whole ovarian dispersates with IL-1 beta (10 ng/ml) produced substantial increments in the accumulation of extracellular macromolecular material [11.5-, 2.9- and 2.6-fold for hyaluronic acid (HA), heparan sulfate (HS) and dermatan sulfate (DS) proteoglycans, respectively].	Heparitin Sulfate	227-229	interleukin 1 beta	Rattus norvegicus	44-53
8227171-0	1993	Membrane-anchored proteoglycans of mouse macrophages: P388D1 cells express a syndecan-4-like heparan sulfate proteoglycan and a distinct chondroitin sulfate form.	Heparitin Sulfate	93-108	syndecan 4	Mus musculus	77-87
8227171-8	1993	Isolation of this proteoglycan indicates that it is likely syndecan-4: it is expressed as a heparan sulfate proteoglycan at the cell surface, it is cleaved from the plasma membrane by low concentrations of trypsin, and it consists of a single 37 kD core protein moiety that co-migrates with syndecan-4 isolated from NMuMG mouse mammary epithelial cells.	Heparitin Sulfate	92-107	syndecan 4	Mus musculus	59-69
8263410-4	1993	Of these molecules, antithrombin III and basic fibroblast growth factor have been shown to bind to specific cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	121-136	serpin family C member 1	Bos taurus	20-36
8263410-4	1993	Of these molecules, antithrombin III and basic fibroblast growth factor have been shown to bind to specific cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	121-136	fibroblast growth factor 2	Bos taurus	41-71
8276720-4	1993	HGF/SF is well known to have a strong affinity for heparin in vitro, and from the results of our immunohistochemical assay, we considered that HGF/SF was bound to heparin or heparan sulfate of the extracellular matrix and basement membrane.	Heparitin Sulfate	174-189	hepatocyte growth factor	Homo sapiens	0-6
8276720-4	1993	HGF/SF is well known to have a strong affinity for heparin in vitro, and from the results of our immunohistochemical assay, we considered that HGF/SF was bound to heparin or heparan sulfate of the extracellular matrix and basement membrane.	Heparitin Sulfate	174-189	hepatocyte growth factor	Homo sapiens	143-149
8234307-1	1993	The complete intron-exon organization of the gene encoding human perlecan (HSPG2), the major heparan sulfate proteoglycan of basement membranes, has been elucidated, and specific exons have been assigned to coding sequences for the modular domains of the protein core.	Heparitin Sulfate	93-108	heparan sulfate proteoglycan 2	Homo sapiens	75-80
8249120-7	1993	C1 inh prevented, in a dose-dependent manner, activation of the endothelial cells, as manifested by release of heparan sulfate.	Heparitin Sulfate	111-126	serpin family G member 1	Homo sapiens	0-6
8376367-0	1993	Regulation of biosynthesis of the basic fibroblast growth factor binding domains of heparan sulfate by heparan sulfate-N-deacetylase/N-sulfotransferase expression.	Heparitin Sulfate	84-99	fibroblast growth factor 2	Rattus norvegicus	34-64
8407001-4	1993	Treatment of early-passage human metastatic melanoma cells (MeWo) or their variants (3S5, 70W) with biologically active 2.5S NGF resulted in (a) delayed density-dependent inhibition of melanoma cell growth; (b) increased in vitro invasion through a reconstituted basement membrane; and (c) time- and dose-dependent induction of heparanase, a heparan-sulfate-specific endo-beta-D-glucuronidase associated with human melanoma metastasis.	Heparitin Sulfate	342-357	nerve growth factor	Homo sapiens	125-128
8219366-2	1993	In this study, we investigated the effect of an aldose reductase inhibitor, statil, on glomerular synthesis of heparan sulfate and albuminuria in male Wistar rats made diabetic with streptozotocin.	Heparitin Sulfate	111-126	aldo-keto reductase family 1 member B1	Rattus norvegicus	48-64
8239278-8	1993	Our studies suggest that following release from the cell membrane, APP interacts with components of the extracellular matrix (ECM) such as the heparan sulfate proteoglycans (HSPG"s).	Heparitin Sulfate	143-158	heparan sulfate proteoglycan 2	Gallus gallus	174-178
8376367-0	1993	Regulation of biosynthesis of the basic fibroblast growth factor binding domains of heparan sulfate by heparan sulfate-N-deacetylase/N-sulfotransferase expression.	Heparitin Sulfate	84-99	N-deacetylase and N-sulfotransferase 1	Rattus norvegicus	103-151
8376367-1	1993	Heparan sulfate-N-deacetylase/N-sulfotransferase catalyzes both the N-deacetylation and N-sulfation reactions that initiate the modification of the oligosaccharide backbone of heparan sulfate (HS).	Heparitin Sulfate	176-191	N-deacetylase and N-sulfotransferase 1	Rattus norvegicus	0-48
8376367-1	1993	Heparan sulfate-N-deacetylase/N-sulfotransferase catalyzes both the N-deacetylation and N-sulfation reactions that initiate the modification of the oligosaccharide backbone of heparan sulfate (HS).	Heparitin Sulfate	193-195	N-deacetylase and N-sulfotransferase 1	Rattus norvegicus	0-48
8244397-1	1993	Deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS; EC 3.1.6.13) results in the storage of the glycosaminoglycans heparan sulfate and dermatan sulfate, which leads to the lysosomal storage disorder mucopolysaccharidosis type II.	Heparitin Sulfate	125-140	iduronate 2-sulfatase	Homo sapiens	35-56
8244397-1	1993	Deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS; EC 3.1.6.13) results in the storage of the glycosaminoglycans heparan sulfate and dermatan sulfate, which leads to the lysosomal storage disorder mucopolysaccharidosis type II.	Heparitin Sulfate	125-140	iduronate 2-sulfatase	Homo sapiens	58-61
8344959-2	1993	Purified brain N-syndecan had biochemical properties very similar to N-syndecan previously identified in Schwann cells: it contained mainly, if not exclusively, heparan sulfate glycosaminoglycan chains and had a core protein with an apparent molecular mass of 120 kDa by sodium dodecyl sulfate-gel electrophoresis.	Heparitin Sulfate	161-176	syndecan 3	Rattus norvegicus	15-25
8270643-10	1993	Syndecan-1, a membrane heparan sulfate/chondroitin sulfate proteoglycan, was associated with fibronectin at the cell surface, partly at focal contacts and in association with stress fibers.	Heparitin Sulfate	23-38	syndecan 1	Homo sapiens	0-10
8270643-10	1993	Syndecan-1, a membrane heparan sulfate/chondroitin sulfate proteoglycan, was associated with fibronectin at the cell surface, partly at focal contacts and in association with stress fibers.	Heparitin Sulfate	23-38	fibronectin 1	Homo sapiens	93-104
8376590-6	1993	Although neither net negative charge nor proportion in total glycosaminoglycans of cell surface heparan sulfate was altered by homocysteine treatment, a substantial reduction in antithrombin III binding capacity of heparan sulfate isolated from homocysteine-treated endothelial cells was found using both affinity chromatography and dot blot assay techniques.	Heparitin Sulfate	215-230	serpin family C member 1	Homo sapiens	178-194
8344959-7	1993	Heparin and heparan sulfate, but not chondroitin sulfate, inhibited N-syndecan-bFGF binding.	Heparitin Sulfate	12-27	syndecan 3	Rattus norvegicus	68-78
8344959-7	1993	Heparin and heparan sulfate, but not chondroitin sulfate, inhibited N-syndecan-bFGF binding.	Heparitin Sulfate	12-27	fibroblast growth factor 2	Rattus norvegicus	79-83
8344959-9	1993	Thus, the heparan sulfate chains of N-syndecan, rather than its core protein, appear to be responsible for binding to bFGF.	Heparitin Sulfate	10-25	syndecan 3	Rattus norvegicus	36-46
8344959-9	1993	Thus, the heparan sulfate chains of N-syndecan, rather than its core protein, appear to be responsible for binding to bFGF.	Heparitin Sulfate	10-25	fibroblast growth factor 2	Rattus norvegicus	118-122
8393416-2	1993	Here, we demonstrate that the unc-52 gene encodes a nematode homolog of perlecan, the mammalian basement membrane heparan sulfate proteoglycan.	Heparitin Sulfate	114-129	Basement membrane proteoglycan;Ig-like domain-containing protein	Caenorhabditis elegans	30-36
8227197-2	1993	At least two families of receptors bind bFGF and could mediate its response: (1) tyrosine kinase-containing FGF receptors, designated FGFR-1 to FGFR-4, and (2) heparan sulfate proteoglycans that bind bFGF through their heparan sulfate chains.	Heparitin Sulfate	160-175	fibroblast growth factor 2	Mus musculus	40-44
8227197-11	1993	Removing the heparan sulfate from these cells eliminates killing by bFGF-saporin.	Heparitin Sulfate	13-28	fibroblast growth factor 2	Mus musculus	68-72
8346230-0	1993	Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8.	Heparitin Sulfate	11-26	C-X-C motif chemokine ligand 8	Homo sapiens	71-84
8349739-0	1993	Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate.	Heparitin Sulfate	129-144	proheparin-binding EGF-like growth factor	Cricetulus griseus	0-38
8349739-1	1993	Heparin-binding EGF-like growth factor (HB-EGF), but not EGF, binds to cell surface heparan sulfate proteoglycan (HSPG).	Heparitin Sulfate	84-99	proheparin-binding EGF-like growth factor	Cricetulus griseus	0-38
8349739-1	1993	Heparin-binding EGF-like growth factor (HB-EGF), but not EGF, binds to cell surface heparan sulfate proteoglycan (HSPG).	Heparitin Sulfate	84-99	proheparin-binding EGF-like growth factor	Cricetulus griseus	40-46
8349739-1	1993	Heparin-binding EGF-like growth factor (HB-EGF), but not EGF, binds to cell surface heparan sulfate proteoglycan (HSPG).	Heparitin Sulfate	84-99	LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein	Cricetulus griseus	114-118
8394371-16	1993	The induced proteoglycan appears at the cell surface as a integral of 100-kD heparan sulfate-rich isoform of syndecan-1.	Heparitin Sulfate	77-92	syndecan 1	Mus musculus	109-119
8346230-5	1993	When IL-8 was applied together with heparan sulfate, neutrophil chemotaxis in vitro was enhanced up to 4-fold, and the stimulus-dependent increase in cytosolic free Ca2+ increased markedly in both rate and peak value.	Heparitin Sulfate	36-51	C-X-C motif chemokine ligand 8	Homo sapiens	5-9
8346230-10	1993	Taken together, these results suggest that heparan sulfate, which is present on the endothelial cell surface and in the basement membrane, may have a dual function in diapedesis, promotion of IL-8-dependent transmigration of neutrophils, and protection of the tissue microenvironment from damage by lytic enzymes released from the migrating cells.	Heparitin Sulfate	43-58	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
7694075-0	1993	Mitogenic activity of acidic fibroblast growth factor is enhanced by highly sulfated oligosaccharides derived from heparin and heparan sulfate.	Heparitin Sulfate	127-142	fibroblast growth factor 1	Homo sapiens	22-53
8340411-0	1993	Structural features of fibronectin synthetic peptide FN-C/H II, responsible for cell adhesion, neurite extension, and heparan sulfate binding.	Heparitin Sulfate	118-133	fibronectin 1	Homo sapiens	23-34
7694075-5	1993	Heparan sulfates extracted from various mammalian tissues were also able to potentiate aFGF mitogenic activity.	Heparitin Sulfate	0-16	fibroblast growth factor 1	Homo sapiens	87-91
7694075-8	1993	These data suggest that the mitogenic activity of aFGF is primarily potentiated by interacting with highly sulfated regions of heparan sulfates chains.	Heparitin Sulfate	127-143	fibroblast growth factor 1	Homo sapiens	50-54
8507869-0	1993	Thrombin-induced release of active basic fibroblast growth factor-heparan sulfate complexes from subendothelial extracellular matrix.	Heparitin Sulfate	66-81	coagulation factor II, thrombin	Homo sapiens	0-8
8236084-8	1993	The drug heparin and blood vessel wall heparan sulfates probably also inhibit SMC growth via suppression of c-myb.	Heparitin Sulfate	39-55	MYB proto-oncogene, transcription factor	Homo sapiens	108-113
7686910-16	1993	It is proposed that LPL binds primarily to cell surface heparan sulfate in monocytes and is presented for endocytosis and degradation by alpha 2MR/LRP.	Heparitin Sulfate	56-71	lipoprotein lipase	Oryctolagus cuniculus	20-23
8331377-0	1993	A heparan sulfate proteoglycan in developing avian axonal tracts.	Heparitin Sulfate	2-17	versican	Gallus gallus	18-30
8331377-4	1993	Antibodies to heparan sulfate proteoglycan from embryonic chick muscle or EHS mouse tumor (perlecan) did not cross-react with the neuronal heparan sulfate proteoglycan, suggesting that the two proteoglycans are not related.	Heparitin Sulfate	14-29	versican	Gallus gallus	30-42
8331377-10	1993	The data show that embryonic neuronal tissue expresses a new type of heparan sulfate proteoglycan.	Heparitin Sulfate	69-84	versican	Gallus gallus	85-97
7686045-5	1993	The presence of similar amounts of other polyanions such as sulfated beta-cyclodextrin or heparan sulfate also stabilizes aFGF to a similar extent as heparin.	Heparitin Sulfate	90-105	fibroblast growth factor 1	Homo sapiens	122-126
8507869-0	1993	Thrombin-induced release of active basic fibroblast growth factor-heparan sulfate complexes from subendothelial extracellular matrix.	Heparitin Sulfate	66-81	fibroblast growth factor 2	Homo sapiens	35-65
8325651-1	1993	Iduronate sulfatase (IDS; EC 3.1.6.13) is a lysosomal enzyme that acts on sulfate groups on C-2 positions of iduronic acid residues of the mucopolysaccharides dermatan and heparan sulfate.	Heparitin Sulfate	172-187	iduronate 2-sulfatase	Mus musculus	0-19
8500274-0	1993	Monoclonal antibodies to heparan sulfate inhibit the formation of thrombin-antithrombin III complexes.	Heparitin Sulfate	25-40	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	75-91
8500274-9	1993	Monoclonal antibodies to HS inhibited the binding of HS to antithrombin III and the formation of thrombin-antithrombin III complexes.	Heparitin Sulfate	25-27	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	59-75
8500274-9	1993	Monoclonal antibodies to HS inhibited the binding of HS to antithrombin III and the formation of thrombin-antithrombin III complexes.	Heparitin Sulfate	25-27	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	106-122
8500274-9	1993	Monoclonal antibodies to HS inhibited the binding of HS to antithrombin III and the formation of thrombin-antithrombin III complexes.	Heparitin Sulfate	53-55	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	59-75
8500274-13	1993	Anti-HS antibodies may promote a procoagulant state by the blockade of HS binding to antithrombin III, inhibiting the accelerated formation of thrombin-antithrombin III complexes.	Heparitin Sulfate	5-7	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	85-101
8500274-13	1993	Anti-HS antibodies may promote a procoagulant state by the blockade of HS binding to antithrombin III, inhibiting the accelerated formation of thrombin-antithrombin III complexes.	Heparitin Sulfate	5-7	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	152-168
8358152-1	1993	Platelet factor 4 (PF4) is a platelet-derived protein capable of binding to, and thus neutralizing, the biological activities of heparin and heparan sulphate.	Heparitin Sulfate	141-157	platelet factor 4	Homo sapiens	0-17
8496192-1	1993	Syndecan-1, the prototype of a family of heparan sulfate-containing integral membrane proteoglycans, associates extracellularly with a variety of matrix molecules and growth factors and intracellularly with the actin cytoskeleton.	Heparitin Sulfate	41-56	syndecan 1	Mus musculus	0-10
8358152-1	1993	Platelet factor 4 (PF4) is a platelet-derived protein capable of binding to, and thus neutralizing, the biological activities of heparin and heparan sulphate.	Heparitin Sulfate	141-157	platelet factor 4	Homo sapiens	19-22
7683668-12	1993	It remains to be determined whether the heparan sulfate proteoglycan can function by itself in both the binding and internalization of the apoE-enriched remnants or whether the proteoglycan is part of a complex with LRP that mediates a two-step process, i.e. binding and subsequent internalization by the receptor.	Heparitin Sulfate	40-55	apolipoprotein E	Homo sapiens	139-143
8508806-7	1993	The capacity of different GAGs to protect bFGF from proteolytic cleavage decreases in the following order: heparin &gt; heparan sulfate &gt; dermatan sulfate = chondroitin sulfates A and C &gt; hyaluronic acid = K5 polysaccharide, indicating that both the degree of sulfation and the backbone structure of GAG modulate its interaction with bFGF.	Heparitin Sulfate	120-135	fibroblast growth factor 2	Homo sapiens	42-46
8483907-3	1993	We now report that in the rat liver, biosynthesis of heparan sulfate utilizes a single protein that possesses both N-deacetylase and N-sulfotransferase activities.	Heparitin Sulfate	53-68	sulfotransferase family 1D, member 1	Rattus norvegicus	133-151
8497125-9	1993	Areas of deposition of bFGF in the ECM partly corresponded to areas of increased immunoreactivity for heparan sulphate proteoglycan.	Heparitin Sulfate	102-118	fibroblast growth factor 2	Homo sapiens	23-27
8473288-2	1993	Binding to heparan sulfate governs many aspects of the physiological action and regulation of the lipolytic enzyme, lipoprotein lipase (LPL).	Heparitin Sulfate	11-26	lipoprotein lipase	Homo sapiens	116-134
8473288-2	1993	Binding to heparan sulfate governs many aspects of the physiological action and regulation of the lipolytic enzyme, lipoprotein lipase (LPL).	Heparitin Sulfate	11-26	lipoprotein lipase	Homo sapiens	136-139
8436596-4	1993	Active u-PA and t-PA were released from ECM by treatment with heparanase (endo-beta-D-glucuronidase), indicating that some of the ECM-resident PA activity is sequestered by heparan sulfate side chains.	Heparitin Sulfate	173-188	plasminogen activator, urokinase	Bos taurus	7-11
7681826-12	1993	Heparin and heparan sulfate, but not other glycosaminoglycans such as chondroitin sulfate, efficiently inhibited the binding of 125I-VEGF to alpha 2M.	Heparitin Sulfate	12-27	vascular endothelial growth factor A	Homo sapiens	133-137
7681826-12	1993	Heparin and heparan sulfate, but not other glycosaminoglycans such as chondroitin sulfate, efficiently inhibited the binding of 125I-VEGF to alpha 2M.	Heparitin Sulfate	12-27	alpha-2-macroglobulin	Homo sapiens	141-149
8495865-2	1993	The anticoagulantly active heparan sulfate proteoglycans (HSPGact) which bind tightly to AT III bear mainly anticoagulantly active heparan sulfate (HSact) whereas the anticoagulantly inactive heparan sulfate proteoglycans (HSPGinact) possess mainly anticoagulantly inactive heparan sulfate (HSinact).	Heparitin Sulfate	27-42	serpin family C member 1	Rattus norvegicus	89-95
8495865-2	1993	The anticoagulantly active heparan sulfate proteoglycans (HSPGact) which bind tightly to AT III bear mainly anticoagulantly active heparan sulfate (HSact) whereas the anticoagulantly inactive heparan sulfate proteoglycans (HSPGinact) possess mainly anticoagulantly inactive heparan sulfate (HSinact).	Heparitin Sulfate	131-146	serpin family C member 1	Rattus norvegicus	89-95
8495865-2	1993	The anticoagulantly active heparan sulfate proteoglycans (HSPGact) which bind tightly to AT III bear mainly anticoagulantly active heparan sulfate (HSact) whereas the anticoagulantly inactive heparan sulfate proteoglycans (HSPGinact) possess mainly anticoagulantly inactive heparan sulfate (HSinact).	Heparitin Sulfate	131-146	serpin family C member 1	Rattus norvegicus	89-95
8495865-2	1993	The anticoagulantly active heparan sulfate proteoglycans (HSPGact) which bind tightly to AT III bear mainly anticoagulantly active heparan sulfate (HSact) whereas the anticoagulantly inactive heparan sulfate proteoglycans (HSPGinact) possess mainly anticoagulantly inactive heparan sulfate (HSinact).	Heparitin Sulfate	131-146	serpin family C member 1	Rattus norvegicus	89-95
8491669-6	1993	Heparan sulphate was also seen to co-distribute with the extracellular matrix protein, fibronectin, when endothelial cultures were simultaneously stained with cationic gold and an antibody to cellular fibronectin.	Heparitin Sulfate	0-16	fibronectin 1	Homo sapiens	87-98
8491669-6	1993	Heparan sulphate was also seen to co-distribute with the extracellular matrix protein, fibronectin, when endothelial cultures were simultaneously stained with cationic gold and an antibody to cellular fibronectin.	Heparitin Sulfate	0-16	fibronectin 1	Homo sapiens	201-212
8452552-3	1993	Heparin and dextran sulphate 5000 inhibited the proteolysis, suggesting that EC-SOD C sequestered by heparan sulphate proteoglycan in vivo is partially protected against proteolysis.	Heparitin Sulfate	101-117	superoxide dismutase 3	Homo sapiens	77-83
8436596-4	1993	Active u-PA and t-PA were released from ECM by treatment with heparanase (endo-beta-D-glucuronidase), indicating that some of the ECM-resident PA activity is sequestered by heparan sulfate side chains.	Heparitin Sulfate	173-188	plasminogen activator, tissue type	Bos taurus	16-20
8431453-6	1993	We conclude that adult bovine myocardium contains a membrane-associated bFGF-binding heparan sulfate proteoglycan containing little or no chondroitin sulfate and that this HSPG may be distinct from those of the syndecan family of heparan sulfate proteoglycans.	Heparitin Sulfate	230-245	fibroblast growth factor 2	Bos taurus	72-76
8431448-4	1993	Inhibition of thrombin by PAI-1 was quantitatively analyzed in the presence of a wide range of concentrations of heparin, heparan sulfate, dermatan sulfate, chondroitin 4-sulfate, chondroitin 6-sulfate, keratan sulfate, and hyaluronic acid by measuring residual amidolytic activity.	Heparitin Sulfate	122-137	serpin family E member 1	Homo sapiens	26-31
8431453-6	1993	We conclude that adult bovine myocardium contains a membrane-associated bFGF-binding heparan sulfate proteoglycan containing little or no chondroitin sulfate and that this HSPG may be distinct from those of the syndecan family of heparan sulfate proteoglycans.	Heparitin Sulfate	85-100	fibroblast growth factor 2	Bos taurus	72-76
8429005-5	1993	In general, the LPL mutants with a decrease in regional positive charge showed a decrease in affinity for heparin and heparan sulfate proteoglycans.	Heparitin Sulfate	118-133	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	16-19
8429005-12	1993	In addition, specific activity of the cell-associated and secreted LPL is correlated to affinity of the enzyme for heparan sulfate chains.	Heparitin Sulfate	115-130	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	67-70
8461056-7	1993	We propose that following LPL-mediated binding of beta VLDL to heparan sulphate, this complex either undergoes endocytosis, or translocation of cholesteryl ester into the smooth muscle cells (SMC) occurs without endocytosis of the entire particle.	Heparitin Sulfate	63-79	lipoprotein lipase	Homo sapiens	26-29
8427968-6	1993	Cell binding assays show that myeloma cells expressing syndecan bind to type I collagen via heparan sulfate chains, while those cell lines not expressing syndecan do not bind to collagen.	Heparitin Sulfate	92-107	syndecan 1	Homo sapiens	55-63
8448389-0	1993	Selective impairment of the synthesis of basic fibroblast growth factor binding domains of heparan sulphate in a COS cell mutant defective in N-sulphotransferase.	Heparitin Sulfate	91-107	fibroblast growth factor 2	Homo sapiens	41-71
8381106-1	1993	Extracellular-superoxide dismutase C (EC-SOD C) is a secretory tetrameric Cu- and Zn-containing glycoprotein which has high affinity for heparin and heparan sulfate.	Heparitin Sulfate	149-164	superoxide dismutase 3	Homo sapiens	38-44
8381453-10	1993	The results provide evidence that a heparin-releasable pool of newly synthesized apoE is associated with cell surface GAGs that resemble heparin and/or heparan sulfate.	Heparitin Sulfate	152-167	apolipoprotein E	Homo sapiens	81-85
8154338-4	1993	There are probably two major pathways for regulating the availability of thrombin in vivo: inactivation of thrombin (by antithrombin III/vessel wall heparan sulfate and perhaps by other endogenous antithrombins) and the inactivation of factor Va and factor VIIIa by activated protein C. Factor Va and factor VIIIa accelerate the production of thrombin.	Heparitin Sulfate	149-164	coagulation factor II, thrombin	Homo sapiens	73-81
8154338-4	1993	There are probably two major pathways for regulating the availability of thrombin in vivo: inactivation of thrombin (by antithrombin III/vessel wall heparan sulfate and perhaps by other endogenous antithrombins) and the inactivation of factor Va and factor VIIIa by activated protein C. Factor Va and factor VIIIa accelerate the production of thrombin.	Heparitin Sulfate	149-164	coagulation factor II, thrombin	Homo sapiens	107-115
8154338-4	1993	There are probably two major pathways for regulating the availability of thrombin in vivo: inactivation of thrombin (by antithrombin III/vessel wall heparan sulfate and perhaps by other endogenous antithrombins) and the inactivation of factor Va and factor VIIIa by activated protein C. Factor Va and factor VIIIa accelerate the production of thrombin.	Heparitin Sulfate	149-164	coagulation factor II, thrombin	Homo sapiens	107-115
1464614-8	1992	Heparin, heparan sulfate, and heparinase all induced the release of VEGF165 and VEGF189, suggesting heparin-containing proteoglycans as candidate VEGF-binding sites.	Heparitin Sulfate	9-24	vascular endothelial growth factor A	Homo sapiens	68-72
8430794-9	1993	The data obtained are compatible with the hypothesis that lactoferrin and other proteins with similarly high affinity for hepatic heparan sulfate exert their negative effect on iron uptake by preventing transferrin binding to the proteoglycan.	Heparitin Sulfate	130-145	lactotransferrin	Rattus norvegicus	58-69
8430794-10	1993	The possibility is thus raised that the large number of low-affinity transferrin binding sites reported by earlier investigators for the liver may be heparan sulfate molecules.	Heparitin Sulfate	150-165	transferrin	Rattus norvegicus	69-80
1472758-0	1992	Heparan sulphate in the binding and activation of basic fibroblast growth factor.	Heparitin Sulfate	0-16	fibroblast growth factor 2	Homo sapiens	50-80
1335242-4	1992	Arguments are presented that anti-viral effects of HBNF and MK are due to the competition for the specific binding to the cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	135-150	pleiotrophin	Homo sapiens	51-55
1493802-10	1992	Sulfated polysaccharides such as heparinsulfate and dermatansulfate modulate the interaction of 5"-nucleotidase and laminin/nidogen in a complex biphasic manner and might also regulate the binding reaction in vivo.	Heparitin Sulfate	33-47	5'-nucleotidase ecto	Gallus gallus	96-111
1493802-10	1992	Sulfated polysaccharides such as heparinsulfate and dermatansulfate modulate the interaction of 5"-nucleotidase and laminin/nidogen in a complex biphasic manner and might also regulate the binding reaction in vivo.	Heparitin Sulfate	33-47	laminin, beta 2 (laminin S)	Gallus gallus	116-123
1279676-10	1992	The interaction between extracellular matrix proteins and 4-1BB was completely blocked by the anionic carbohydrate polymer fucoidan and was partially blocked by the anionic carbohydrate polymer dextran sulfate and the glycosaminoglycan heparin sulfate but was unaffected by desulfated heparin.	Heparitin Sulfate	236-251	TNF receptor superfamily member 9	Homo sapiens	58-63
1484387-13	1992	These results strongly suggest that, within the assay system, the NCAM HBD does not participate in homophilic interactions but binds to cell surface heparan sulfate proteoglycan.	Heparitin Sulfate	149-164	neural cell adhesion molecule 1	Homo sapiens	66-70
1331122-0	1992	Transforming growth factor beta 1 and adrenocorticotropin differentially regulate the synthesis of adrenocortical cell heparan sulfate proteoglycans and their binding of basic fibroblast growth factor.	Heparitin Sulfate	119-134	transforming growth factor beta 1	Homo sapiens	0-33
1331122-9	1992	The subpopulation of heparan sulfate proteoglycans capable to bind bFGF was also largely increased after ACTH or TGF beta treatment and paralleled the variation in overall proteoheparan sulfate synthesis.	Heparitin Sulfate	21-36	fibroblast growth factor 2	Homo sapiens	67-71
1331122-9	1992	The subpopulation of heparan sulfate proteoglycans capable to bind bFGF was also largely increased after ACTH or TGF beta treatment and paralleled the variation in overall proteoheparan sulfate synthesis.	Heparitin Sulfate	21-36	proopiomelanocortin	Homo sapiens	105-109
1331122-9	1992	The subpopulation of heparan sulfate proteoglycans capable to bind bFGF was also largely increased after ACTH or TGF beta treatment and paralleled the variation in overall proteoheparan sulfate synthesis.	Heparitin Sulfate	21-36	transforming growth factor beta 1	Homo sapiens	113-121
1477980-3	1992	EC-SOD is the major SOD isozyme in plasma and forms an equilibrium between the plasma phase and heparan sulfate proteoglycan on the surface of the endothelium.	Heparitin Sulfate	96-111	superoxide dismutase 3	Homo sapiens	0-6
1477980-3	1992	EC-SOD is the major SOD isozyme in plasma and forms an equilibrium between the plasma phase and heparan sulfate proteoglycan on the surface of the endothelium.	Heparitin Sulfate	96-111	superoxide dismutase 3	Homo sapiens	3-6
1429568-5	1992	Internalization of bFGF through the heparin-sensitive pathway was not efficiently competed by unlabeled bFGF and did not approach saturation at concentrations of bFGF up to 50 ng/ml, properties similar to the interaction of bFGF with low affinity heparan sulfate binding sites on the cell surface.	Heparitin Sulfate	247-262	fibroblast growth factor 2	Bos taurus	19-23
1429568-6	1992	Internalization of bFGF in CHO cells not expressing FGF receptors was inhibited by heparin, heparan sulfate, and dermatan sulfate, the same glycosaminoglycans that block binding to cell-surface heparin sulfates.	Heparitin Sulfate	92-107	fibroblast growth factor 2	Bos taurus	19-23
1429568-6	1992	Internalization of bFGF in CHO cells not expressing FGF receptors was inhibited by heparin, heparan sulfate, and dermatan sulfate, the same glycosaminoglycans that block binding to cell-surface heparin sulfates.	Heparitin Sulfate	92-107	fibroblast growth factor 2	Bos taurus	20-23
1429568-6	1992	Internalization of bFGF in CHO cells not expressing FGF receptors was inhibited by heparin, heparan sulfate, and dermatan sulfate, the same glycosaminoglycans that block binding to cell-surface heparin sulfates.	Heparitin Sulfate	194-210	fibroblast growth factor 2	Bos taurus	19-23
1429568-6	1992	Internalization of bFGF in CHO cells not expressing FGF receptors was inhibited by heparin, heparan sulfate, and dermatan sulfate, the same glycosaminoglycans that block binding to cell-surface heparin sulfates.	Heparitin Sulfate	194-210	fibroblast growth factor 2	Bos taurus	20-23
1429568-7	1992	Internalization of bFGF in the parental CHO cells was inhibited at the same concentrations of heparin that block binding to cell-surface heparan sulfates.	Heparitin Sulfate	137-153	fibroblast growth factor 2	Bos taurus	19-23
1429568-8	1992	Finally, inhibition of the sulfation of CHO cell heparan sulfates by the addition of chlorate or digestion of CHO cell heparan sulfates with heparinase inhibited bFGF internalization in the parental CHO cells.	Heparitin Sulfate	49-65	fibroblast growth factor 2	Bos taurus	162-166
1429568-9	1992	These results demonstrate that bFGF can be internalized through a direct interaction with cell-surface heparan sulfates.	Heparitin Sulfate	103-119	fibroblast growth factor 2	Bos taurus	31-35
1429568-10	1992	Thus, there are two pathways for internalization of bFGF: high affinity receptor-mediated and heparan sulfate-mediated.	Heparitin Sulfate	94-109	fibroblast growth factor 2	Bos taurus	52-56
1430223-0	1992	Lipoprotein lipase enhances binding of lipoproteins to heparan sulfate on cell surfaces and extracellular matrix.	Heparitin Sulfate	55-70	lipoprotein lipase	Homo sapiens	0-18
1430223-3	1992	Lipoprotein lipase causes only a minimal effect on the binding of lipoproteins to heparan sulfate deficient mutant Chinese hamster ovary cells while it promotes binding to wild type cells that is abolished after heparinase treatment.	Heparitin Sulfate	82-97	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	0-18
1430223-5	1992	These observations prove that lipoprotein lipase causes, predominantly, binding of lipoproteins to heparan sulfate at cell surfaces and in extracellular matrix rather than to receptors.	Heparitin Sulfate	99-114	lipoprotein lipase	Homo sapiens	30-48
1465181-0	1992	Acetylcholinesterase and its association with heparan sulphate proteoglycans in cortical amyloid deposits of Alzheimer"s disease.	Heparitin Sulfate	46-62	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
1465181-3	1992	Heparan sulphate, heparinase lyase type I and to a lesser degree, heparin and chondroitin sulphate were effective in solubilizing a large part of the cholinesterase activity.	Heparitin Sulfate	0-16	butyrylcholinesterase	Homo sapiens	150-164
1516155-3	1992	However, the percentage of total radiolabeled heparan sulfate that bound to antithrombin III was increased by 33% for BAECs and by 120% for BPAECs when compared with radiolabeled heparan sulfate synthesized during the 21% oxygen exposure.	Heparitin Sulfate	46-61	serpin family C member 1	Bos taurus	76-92
1400436-2	1992	Heparan sulfate binding may limit bFGF degradation and be an obligatory step for bFGF cell interaction.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Mus musculus	34-38
1400436-2	1992	Heparan sulfate binding may limit bFGF degradation and be an obligatory step for bFGF cell interaction.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Mus musculus	81-85
1400436-11	1992	These results suggest that the ability of TGF-beta 1 to stimulate binding of bFGF to ECM, increase ECM heparan sulfate proteoglycan, and potentiate the mitogenic activity of bFGF are linked.	Heparitin Sulfate	103-118	transforming growth factor, beta 1	Mus musculus	42-52
1516155-4	1992	Both the high- and low-antithrombin III affinity radiolabeled heparan sulfate consisted of two components of different sizes; the low-affinity components (mean sizes, 60 and 40 kd) generated under normoxic conditions were smaller than their respective high-affinity components (mean sizes, 70 and 55 kd) by molecular sieve chromatography.	Heparitin Sulfate	62-77	serpin family C member 1	Bos taurus	23-39
1516155-5	1992	The components of low-antithrombin III affinity heparan sulfate generated during exposure to 3% oxygen were increased in size compared with the corresponding low-affinity components generated during the 21% oxygen exposure for both BPAECs and BAECs.	Heparitin Sulfate	48-63	serpin family C member 1	Bos taurus	22-38
1383494-2	1992	In the presence of 5 U/ml of heparin to block [125I]aFGF binding to membrane bound heparan sulfate proteoglycans, specific [125I]aFGF binding was optimal in the presence of 0.2 M NaCl and in a pH range of 7 to 9.	Heparitin Sulfate	83-98	fibroblast growth factor 1	Homo sapiens	52-56
1468448-10	1992	In contrast, significant bFGF levels were observed in association with the EC and mesangial cells of the renal corpuscle, where heparan sulfate accumulates within the glomerular basement membrane.	Heparitin Sulfate	128-143	fibroblast growth factor 2	Mus musculus	25-29
1401995-8	1992	This structural difference is due to larger and more heparan sulfate chains on syndecan-1 from monolayer cells.	Heparitin Sulfate	53-68	syndecan 1	Mus musculus	79-89
1458440-7	1992	Neuraminidase or heparinase treatment of VEC increased the adhesion of both normal and diabetic platelets, indicating that the cell membrane sialyl residues and heparan sulfate participate in the normal thromboresistant properties of VEC.	Heparitin Sulfate	161-176	neuraminidase 1	Homo sapiens	0-13
1383494-12	1992	However, at a low heparin concentration (0.1 U/ml), [125I]aFGF binds to the FGF-flg receptor with higher affinity than was observed in the presence of 5 U/ml of heparin, and also binds a class of lower affinity recognition sites which are consistent with the labeling of cell surface heparan sulfate proteoglycans.	Heparitin Sulfate	284-299	fibroblast growth factor 1	Homo sapiens	58-62
1505778-1	1992	The secretory enzyme extracellular-superoxide dismutase (EC-SOD) has affinity for heparin and some other sulfated glycosaminoglycans and is in vivo bound to heparan sulfate proteoglycan.	Heparitin Sulfate	157-172	superoxide dismutase 3	Homo sapiens	21-55
1525174-0	1992	Binding of interferon-gamma to heparan sulfate is restricted to the heparin-like domains and involves carboxylic--but not N-sulfated--groups.	Heparitin Sulfate	31-46	interferon gamma	Homo sapiens	11-27
1525174-4	1992	Furthermore, using heparan sulfate and heparin treated with heparinases I and III, we have shown that the interferon-gamma binding sites are localized on the N-sulfated glucosamine rich domains of the molecule.	Heparitin Sulfate	19-34	interferon gamma	Homo sapiens	106-122
1521532-1	1992	A large, low-density form of heparan sulfate proteoglycan was isolated from the Engelbreth-Holm-Swarm (EHS) tumor and demonstrated to bind in immobilized-ligand assays to laminin fragment E3, collagen type IV, fibronectin and nidogen.	Heparitin Sulfate	29-44	fibronectin 1	Homo sapiens	210-221
1525174-5	1992	Interestingly, interferon-gamma and fibroblast growth factor compete for the same binding domain on heparan sulfate, although they are unrelated proteins.	Heparitin Sulfate	100-115	interferon gamma	Homo sapiens	15-31
1517210-4	1992	Heparin/heparan sulfate interaction is required before, e.g. basic fibroblast growth factor (bFGF) can associate with its high affinity cell surface receptors and trigger signal transduction.	Heparitin Sulfate	8-23	fibroblast growth factor 2	Mus musculus	61-91
1517210-4	1992	Heparin/heparan sulfate interaction is required before, e.g. basic fibroblast growth factor (bFGF) can associate with its high affinity cell surface receptors and trigger signal transduction.	Heparitin Sulfate	8-23	fibroblast growth factor 2	Mus musculus	93-97
1517210-6	1992	Moreover, increased DNA synthesis of 3T3 cells was observed when the 3T3 cells were exposed to beads coated with the fibronectin-syndecan-bFGF complex, indicating that bFGF remains biologically active even when immobilized to matrix via the heparan sulfate chains of syndecan.	Heparitin Sulfate	241-256	fibronectin 1	Mus musculus	117-128
1517210-6	1992	Moreover, increased DNA synthesis of 3T3 cells was observed when the 3T3 cells were exposed to beads coated with the fibronectin-syndecan-bFGF complex, indicating that bFGF remains biologically active even when immobilized to matrix via the heparan sulfate chains of syndecan.	Heparitin Sulfate	241-256	fibroblast growth factor 2	Mus musculus	138-142
1517210-6	1992	Moreover, increased DNA synthesis of 3T3 cells was observed when the 3T3 cells were exposed to beads coated with the fibronectin-syndecan-bFGF complex, indicating that bFGF remains biologically active even when immobilized to matrix via the heparan sulfate chains of syndecan.	Heparitin Sulfate	241-256	fibroblast growth factor 2	Mus musculus	168-172
1505778-1	1992	The secretory enzyme extracellular-superoxide dismutase (EC-SOD) has affinity for heparin and some other sulfated glycosaminoglycans and is in vivo bound to heparan sulfate proteoglycan.	Heparitin Sulfate	157-172	superoxide dismutase 3	Homo sapiens	57-63
1394971-0	1992	Embryonic brain-derived heparan sulfate inhibits cellular membrane binding and biological activity of basic fibroblast growth factor.	Heparitin Sulfate	24-39	fibroblast growth factor 2	Rattus norvegicus	102-132
1394971-6	1992	Incubation with [125I]bFGF followed or not by heparinase and chondroitinase treatment of electrotransfert from SDS-PAGE revealed that both of these forms correspond to heparan sulfate chains and bind bFGF.	Heparitin Sulfate	168-183	fibroblast growth factor 2	Rattus norvegicus	22-26
1394971-4	1992	This activity was dose-dependent and on the basis to its heparinase sensitivity and chondroitinase insensitivity, has been attributed to heparan sulfate.	Heparitin Sulfate	137-152	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	84-98
1394971-7	1992	In vitro, embryonic brain-derived heparan sulfate inhibited both bFGF induced [3H]thymidine incorporation in CCL39 cells and neurite outgrowth in PC12 cells.	Heparitin Sulfate	34-49	fibroblast growth factor 2	Rattus norvegicus	65-69
1394971-8	1992	These results suggest that heparan sulfate play an important function in the control of the biological activity of bFGF during brain development.	Heparitin Sulfate	27-42	fibroblast growth factor 2	Rattus norvegicus	115-119
1613389-1	1992	The subcellular localization of a heparan sulfate degrading endoglycosidase, heparanase, was studied in human neutrophils.	Heparitin Sulfate	34-49	heparanase	Homo sapiens	77-87
1497618-1	1992	Binding of basic fibroblast growth factor (bFGF) to the extracellular matrix of cultured bovine aorta smooth muscle cells is likely to be mediated via heparan sulphate, since not only exogenous addition of heparan sulphate to the culture medium but also pretreatment of the cells with heparitinase (but not chondroitinase ABC) resulted in loss of binding.	Heparitin Sulfate	151-167	fibroblast growth factor 2	Bos taurus	11-41
1497618-1	1992	Binding of basic fibroblast growth factor (bFGF) to the extracellular matrix of cultured bovine aorta smooth muscle cells is likely to be mediated via heparan sulphate, since not only exogenous addition of heparan sulphate to the culture medium but also pretreatment of the cells with heparitinase (but not chondroitinase ABC) resulted in loss of binding.	Heparitin Sulfate	151-167	fibroblast growth factor 2	Bos taurus	43-47
1497618-1	1992	Binding of basic fibroblast growth factor (bFGF) to the extracellular matrix of cultured bovine aorta smooth muscle cells is likely to be mediated via heparan sulphate, since not only exogenous addition of heparan sulphate to the culture medium but also pretreatment of the cells with heparitinase (but not chondroitinase ABC) resulted in loss of binding.	Heparitin Sulfate	206-222	fibroblast growth factor 2	Bos taurus	11-41
1497618-1	1992	Binding of basic fibroblast growth factor (bFGF) to the extracellular matrix of cultured bovine aorta smooth muscle cells is likely to be mediated via heparan sulphate, since not only exogenous addition of heparan sulphate to the culture medium but also pretreatment of the cells with heparitinase (but not chondroitinase ABC) resulted in loss of binding.	Heparitin Sulfate	206-222	fibroblast growth factor 2	Bos taurus	43-47
1497618-2	1992	Comparison of the affinity of bFGF to various glycosaminoglycan-conjugated gels showed a direct and specific binding of bFGF to heparan sulphate.	Heparitin Sulfate	128-144	fibroblast growth factor 2	Mus musculus	30-34
1497618-2	1992	Comparison of the affinity of bFGF to various glycosaminoglycan-conjugated gels showed a direct and specific binding of bFGF to heparan sulphate.	Heparitin Sulfate	128-144	fibroblast growth factor 2	Mus musculus	120-124
1497618-3	1992	Heparan sulphate also bound to a bFGF affinity gel.	Heparitin Sulfate	0-16	fibroblast growth factor 2	Mus musculus	33-37
1497618-5	1992	The bound heparan sulphate had the ability to protect bFGF from proteolytic digestion, but the unbound heparan sulphate did not.	Heparitin Sulfate	10-26	fibroblast growth factor 2	Mus musculus	54-58
1497618-12	1992	It is likely that the binding of bFGF to heparan sulphate may require the domain structure of the heparan sulphate to be composed of clustering IdoA(2SO4)-GlcNSO3 units.	Heparitin Sulfate	41-57	fibroblast growth factor 2	Mus musculus	33-37
1497618-12	1992	It is likely that the binding of bFGF to heparan sulphate may require the domain structure of the heparan sulphate to be composed of clustering IdoA(2SO4)-GlcNSO3 units.	Heparitin Sulfate	98-114	fibroblast growth factor 2	Mus musculus	33-37
1505961-1	1992	In humans, a deficiency of the lysosomal hydrolase alpha-L-iduronidase (IDUA;EC 3.2.1.76) results in the lysosomal storage of the glycosaminoglycans heparan sulfate and dermatan sulfate, thereby causing the lysosomal storage disorder mucopolysaccharidosis type I.	Heparitin Sulfate	149-164	alpha-L-iduronidase	Homo sapiens	51-70
1505961-1	1992	In humans, a deficiency of the lysosomal hydrolase alpha-L-iduronidase (IDUA;EC 3.2.1.76) results in the lysosomal storage of the glycosaminoglycans heparan sulfate and dermatan sulfate, thereby causing the lysosomal storage disorder mucopolysaccharidosis type I.	Heparitin Sulfate	149-164	alpha-L-iduronidase	Homo sapiens	72-76
1379245-0	1992	Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate.	Heparitin Sulfate	89-104	fibroblast growth factor 1	Homo sapiens	42-46
1379245-0	1992	Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate.	Heparitin Sulfate	89-104	fibroblast growth factor 2	Homo sapiens	48-52
1379245-0	1992	Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate.	Heparitin Sulfate	89-104	fibroblast growth factor 4	Homo sapiens	58-63
1449722-1	1992	Heparan sulphate proteoglycan, labelled with [35S]sulphate, was prepared from rat livers for studies of its interaction with purified rat transferrin.	Heparitin Sulfate	0-16	transferrin	Rattus norvegicus	138-149
1612123-0	1992	Thrombin enhances degradation of heparan sulfate in the extracellular matrix by tumor cell heparanase.	Heparitin Sulfate	33-48	coagulation factor II, thrombin	Homo sapiens	0-8
1612123-1	1992	The ability of normal and malignant blood-borne cells to extravasate correlates with the activity of an endo-beta-D-glucuronidase (heparanase) which degrades heparan sulfate (HS) in the subendothelial extracellular matrix (ECM).	Heparitin Sulfate	158-173	glucuronidase beta	Homo sapiens	109-129
1612123-1	1992	The ability of normal and malignant blood-borne cells to extravasate correlates with the activity of an endo-beta-D-glucuronidase (heparanase) which degrades heparan sulfate (HS) in the subendothelial extracellular matrix (ECM).	Heparitin Sulfate	175-177	glucuronidase beta	Homo sapiens	109-129
1612123-5	1992	Heparanase-mediated release of low Mr HS cleavage products from sulfate-labeled ECM was stimulated four- to sixfold in the presence of alpha-thrombin, but there was no effect on degradation of soluble HS.	Heparitin Sulfate	38-40	coagulation factor II, thrombin	Homo sapiens	141-149
1630581-4	1992	The pretreatment of sections with heparitinase prevented the binding of bFGF to these cells, suggesting that the chemical substrate for the bFGF binding was heparan sulphate.	Heparitin Sulfate	157-173	fibroblast growth factor 2	Rattus norvegicus	72-76
1322148-7	1992	Betaglycan has been purified, molecularly cloned, and shown to bind TGF-beta via its core protein and basic fibroblast growth factor via its heparan sulfate chains.	Heparitin Sulfate	141-156	transforming growth factor, beta receptor III	Mus musculus	0-10
1630581-4	1992	The pretreatment of sections with heparitinase prevented the binding of bFGF to these cells, suggesting that the chemical substrate for the bFGF binding was heparan sulphate.	Heparitin Sulfate	157-173	fibroblast growth factor 2	Rattus norvegicus	140-144
1373495-6	1992	Heparan sulfate proteoglycans have been shown to play an obligate role in basic FGF binding to the high-affinity FLG receptor.	Heparitin Sulfate	0-15	filaggrin	Mus musculus	113-116
1381850-8	1992	Using 0.03U/ml thrombin and 1nM HCII the stimulatory effect of GAGs was completely inhibited when Hep (less than or equal to 0.3 micrograms/ml) was preincubated with VN (60 micrograms/ml) and decreased to less than 50% when HS (50 micrograms/ml) was preincubated with VN (60 micrograms/ml).	Heparitin Sulfate	224-226	serpin family D member 1	Homo sapiens	32-36
1587820-0	1992	Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate.	Heparitin Sulfate	84-99	fibroblast growth factor 2	Homo sapiens	22-52
1587820-1	1992	The structural properties of fibroblast heparan sulfate (HS) that are necessary for it to bind strongly to basic fibroblast growth factor (bFGF) have been investigated using bFGF affinity chromatography.	Heparitin Sulfate	40-55	fibroblast growth factor 2	Homo sapiens	107-137
1587820-1	1992	The structural properties of fibroblast heparan sulfate (HS) that are necessary for it to bind strongly to basic fibroblast growth factor (bFGF) have been investigated using bFGF affinity chromatography.	Heparitin Sulfate	40-55	fibroblast growth factor 2	Homo sapiens	139-143
1587820-1	1992	The structural properties of fibroblast heparan sulfate (HS) that are necessary for it to bind strongly to basic fibroblast growth factor (bFGF) have been investigated using bFGF affinity chromatography.	Heparitin Sulfate	40-55	fibroblast growth factor 2	Homo sapiens	174-178
1587820-1	1992	The structural properties of fibroblast heparan sulfate (HS) that are necessary for it to bind strongly to basic fibroblast growth factor (bFGF) have been investigated using bFGF affinity chromatography.	Heparitin Sulfate	57-59	fibroblast growth factor 2	Homo sapiens	107-137
1587820-1	1992	The structural properties of fibroblast heparan sulfate (HS) that are necessary for it to bind strongly to basic fibroblast growth factor (bFGF) have been investigated using bFGF affinity chromatography.	Heparitin Sulfate	57-59	fibroblast growth factor 2	Homo sapiens	139-143
1587820-1	1992	The structural properties of fibroblast heparan sulfate (HS) that are necessary for it to bind strongly to basic fibroblast growth factor (bFGF) have been investigated using bFGF affinity chromatography.	Heparitin Sulfate	57-59	fibroblast growth factor 2	Homo sapiens	174-178
1315738-5	1992	The glycosaminoglycan specificity of protein C inhibitor was relatively broad, including heparin and heparan sulfate, but not dermatan sulfate.	Heparitin Sulfate	101-116	serpin family A member 5	Homo sapiens	37-56
1550122-1	1992	alpha-L-Iduronidase activity is deficient in mucopolysaccharidosis type I (MPS I; Hurler syndrome, Scheie syndrome) patients and results in the disruption of the sequential degradation of the glycosaminoglycans dermatan sulfate and heparan sulfate.	Heparitin Sulfate	232-247	alpha-L-iduronidase	Homo sapiens	0-19
1566349-1	1992	This is the first study of the antithrombin III-heparan sulfate natural anticoagulant pathway in human kidneys.	Heparitin Sulfate	48-63	serpin family C member 1	Homo sapiens	31-47
1378313-2	1992	Heparin and heparan sulfate protect bFGF from inactivation by heat, extreme pH and protease degradation.	Heparitin Sulfate	12-27	fibroblast growth factor 2	Homo sapiens	36-40
1378313-3	1992	At the cellular level, bFGF binds to heparan sulfate on the cell surface.	Heparitin Sulfate	37-52	fibroblast growth factor 2	Homo sapiens	23-27
1566349-3	1992	Enzymatic studies were done to show that the antithrombin III was anchored to endothelium by molecules of heparan sulfate.	Heparitin Sulfate	106-121	serpin family C member 1	Homo sapiens	45-61
1566349-5	1992	Immunocytochemical studies of biopsies showed that normally functioning renal allografts manifested the endothelial antithrombin III-heparan sulfate anticoagulant pathway.	Heparitin Sulfate	133-148	serpin family C member 1	Homo sapiens	116-132
1566349-7	1992	It is concluded that compromise of the antithrombin III-heparan sulfate natural anticoagulant pathway results in compromised renal function in transplanted kidneys.	Heparitin Sulfate	56-71	serpin family C member 1	Homo sapiens	39-55
1279952-4	1992	(3) FGFs and thrombospondin are stored in the extracellular matrix bound to heparan sulfate; fragments of heparin or heparan sulfate may act as natural chaperones to shuttle bFGF or other growth factors to different cellular compartments.	Heparitin Sulfate	117-132	fibroblast growth factor 2	Homo sapiens	174-178
1556106-2	1992	Betaglycan, a cell surface heparan sulfate/chondroitin sulfate proteoglycan that binds TGF-beta via its core protein, is shown here to bind bFGF via its heparan sulfate chains.	Heparitin Sulfate	153-168	fibroblast growth factor 2	Rattus norvegicus	140-144
1554373-10	1992	A model was proposed whereby the substrate is directed from alpha-L-iduronidase to subsequent enzyme activities to ensure the efficient degradation of heparan sulphate.	Heparitin Sulfate	151-167	alpha-L-iduronidase	Homo sapiens	60-79
1740437-5	1992	The putative ectodomain, which has 85% homology to fibroglycan, contains three possible glycosaminoglycan attachment sites that may be occupied by heparan sulfate chains.	Heparitin Sulfate	147-162	syndecan 2	Rattus norvegicus	51-62
1320301-5	1992	The effect of heparin and heparan sulfate was independent and synergic with respect to thrombomodulin.	Heparitin Sulfate	26-41	thrombomodulin	Oryctolagus cuniculus	87-101
1537864-2	1992	The anticoagulantly active heparan sulfate proteoglycans (HSPGact) which bind tightly to AT III bear mainly anticoagulantly active heparan sulfate (HSact) whereas the anticoagulantly inactive heparan sulfate proteoglycans (HSPGinact) possess mainly anticoagulantly inactive heparan sulfate (HSinact).	Heparitin Sulfate	27-42	serpin family C member 1	Rattus norvegicus	89-95
1537864-2	1992	The anticoagulantly active heparan sulfate proteoglycans (HSPGact) which bind tightly to AT III bear mainly anticoagulantly active heparan sulfate (HSact) whereas the anticoagulantly inactive heparan sulfate proteoglycans (HSPGinact) possess mainly anticoagulantly inactive heparan sulfate (HSinact).	Heparitin Sulfate	131-146	serpin family C member 1	Rattus norvegicus	89-95
1537864-2	1992	The anticoagulantly active heparan sulfate proteoglycans (HSPGact) which bind tightly to AT III bear mainly anticoagulantly active heparan sulfate (HSact) whereas the anticoagulantly inactive heparan sulfate proteoglycans (HSPGinact) possess mainly anticoagulantly inactive heparan sulfate (HSinact).	Heparitin Sulfate	131-146	serpin family C member 1	Rattus norvegicus	89-95
1537864-2	1992	The anticoagulantly active heparan sulfate proteoglycans (HSPGact) which bind tightly to AT III bear mainly anticoagulantly active heparan sulfate (HSact) whereas the anticoagulantly inactive heparan sulfate proteoglycans (HSPGinact) possess mainly anticoagulantly inactive heparan sulfate (HSinact).	Heparitin Sulfate	131-146	serpin family C member 1	Rattus norvegicus	89-95
1536567-3	1992	Heparan sulfate, a component of the endothelial extracellular matrix, was also observed to bind to bFGF and induce a similar conformational change to that observed for heparin.	Heparitin Sulfate	0-15	fibroblast growth factor 2	Homo sapiens	99-103
1582998-3	1992	Furthermore, sulfated polysaccharides such as high and low molecular weight dextran sulfates, heparan sulfate and, to a lesser extent, chondroitin sulfates B and C were also shown to be inhibitors of human keratinocyte-derived AR (k-d AR)-stimulated DNA synthesis in quiescent murine AKR-2B cell cultures.	Heparitin Sulfate	94-109	amphiregulin	Homo sapiens	227-229
1301941-1	1992	Mucopolysaccharidosis type I (MPS-I) is an autosomal recessive genetic disease caused by a deficiency of the glycosidase alpha-L-iduronidase which is required for the lysosomal degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate.	Heparitin Sulfate	215-230	alpha-L-iduronidase	Homo sapiens	121-140
1442267-5	1992	We have demonstrated that mouse LTA cells synthesize cell surface heparan sulfate proteoglycans with regions of defined monosaccharide sequence that specifically interact with antithrombin (HSPGact).	Heparitin Sulfate	66-81	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	176-188
1379965-2	1992	It consists of heparan, dermatan and chondroitin sulfate; a small proportion of heparan sulfate (4%) has high affinity for antithrombin III (AT III).	Heparitin Sulfate	80-95	serpin family C member 1	Homo sapiens	123-139
1379965-2	1992	It consists of heparan, dermatan and chondroitin sulfate; a small proportion of heparan sulfate (4%) has high affinity for antithrombin III (AT III).	Heparitin Sulfate	80-95	serpin family C member 1	Homo sapiens	141-147
1442267-7	1992	To examine this issue, we treated LTA cells with ethylmethane sulfonate and then identified mutants that exhibit decreased antithrombin binding to heparan sulfate chains but possess no gross defects in glycosaminoglycan biosynthesis.	Heparitin Sulfate	147-162	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	123-135
1301196-1	1992	Mucopolysaccharidosis type I (MPS-I) is an autosomal recessive genetic disease caused by a deficiency of the glycosidase alpha-L-iduronidase which is required for the lysosomal degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate.	Heparitin Sulfate	215-230	alpha-L-iduronidase	Homo sapiens	121-140
1593846-1	1992	After immunization of mice with partially-purified heparan sulfate proteoglycan (HSPG) isolated from rat glomeruli, a monoclonal antibody (mAb JM-403) was obtained, which was directed against heparan sulfate (HS), the glycosaminoglycan side chain of HSPG.	Heparitin Sulfate	51-66	syndecan 2	Mus musculus	81-85
1953677-7	1991	We also studied the affinity of the endothelial heparan sulphate chains towards two presumptive biological ligands, namely antithrombin III and lipoprotein lipase.	Heparitin Sulfate	48-64	serpin family C member 1	Homo sapiens	123-139
1661296-8	1991	Also, reduced EBP was observed in fetal lamb and neonatal rat Ao smooth muscle cells incubated with N-acetylgalactosamine GAGs, CS, and DS, but not with N-acetylglucosamine containing GAGs, heparan sulfate (HS), or hyaluronan.	Heparitin Sulfate	190-205	EBP, cholestenol delta-isomerase	Rattus norvegicus	14-17
1661296-8	1991	Also, reduced EBP was observed in fetal lamb and neonatal rat Ao smooth muscle cells incubated with N-acetylgalactosamine GAGs, CS, and DS, but not with N-acetylglucosamine containing GAGs, heparan sulfate (HS), or hyaluronan.	Heparitin Sulfate	207-209	EBP, cholestenol delta-isomerase	Rattus norvegicus	14-17
1661296-11	1991	The EBP extracted from smooth muscle cell membranes binds to an elastin affinity gel and can be eluted from it with CS but not with HS.	Heparitin Sulfate	132-134	EBP, cholestenol delta-isomerase	Rattus norvegicus	4-7
1744125-3	1991	Purified betaglycan has properties similar to betaglycan affinity-labeled in intact cells: it binds TGF-beta 1 and TGF-beta 2 with KD approximately 0.2 nM, contains heparan sulfate and chondroitin sulfate glycosaminoglycan (GAG) chains and N-linked glycans attached to a 110-kDa core protein, and can spontaneously associate with phosphatidylcholine liposomes.	Heparitin Sulfate	165-180	transforming growth factor beta receptor 3	Rattus norvegicus	9-19
1683874-6	1991	Immunofluorescent techniques showed that binding of exogenous TGase to ECM was prevented by prior mixing with fibronectin or collagen, but not with several other ECM components, including laminin, elastin, chondroitin sulfate, heparan sulfate, and hyaluronic acid.	Heparitin Sulfate	227-242	transglutaminase 1	Homo sapiens	62-67
1953677-7	1991	We also studied the affinity of the endothelial heparan sulphate chains towards two presumptive biological ligands, namely antithrombin III and lipoprotein lipase.	Heparitin Sulfate	48-64	lipoprotein lipase	Homo sapiens	144-162
1953677-8	1991	A major part of the endothelial heparan sulphate chains showed a weak affinity for antithrombin III and the affinity was essentially lost on heparinase digestion.	Heparitin Sulfate	32-48	serpin family C member 1	Homo sapiens	83-99
1953677-9	1991	On lipoprotein lipase-agarose the endothelial heparan sulphate chains were eluted at the same salt concentration as heparin, and the binding persisted, although with decreased strength, after digestion with heparinase.	Heparitin Sulfate	46-62	lipoprotein lipase	Homo sapiens	3-21
1936126-0	1991	The role of C5a and antibody in the release of heparan sulfate from endothelial cells.	Heparitin Sulfate	47-62	complement C5a receptor 1	Homo sapiens	12-15
1936126-3	1991	We show here that release of heparan sulfate from endothelial cells is mediated by antibody and the complement fragment C5a and that assembly of the membrane attack complex and lysis of endothelial cells is not necessarily involved.	Heparitin Sulfate	29-44	complement C5a receptor 1	Homo sapiens	120-123
1936126-4	1991	These data suggest that the generation of C5a in conditions such as autoimmunity and infection in which anti-endothelial cell antibodies may also be present, might amplify tissue injury by a novel mechanism involving endothelial cell activation and loss of heparan sulfate mediated by antibody and C5a.	Heparitin Sulfate	257-272	complement C5a receptor 1	Homo sapiens	42-45
1805447-6	1991	On the other hand, A10 cells synthesized both dermatan sulfate and heparan sulfate which are capable of activating HCII.	Heparitin Sulfate	67-82	serine (or cysteine) peptidase inhibitor, clade D, member 1	Mus musculus	115-119
1946389-1	1991	alpha-L-Iduronidase (IDUA; EC 3.2.1.76) is a lysosomal hydrolase in the metabolic pathway responsible for the degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate.	Heparitin Sulfate	148-163	alpha-L-iduronidase	Homo sapiens	0-19
1946389-1	1991	alpha-L-Iduronidase (IDUA; EC 3.2.1.76) is a lysosomal hydrolase in the metabolic pathway responsible for the degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate.	Heparitin Sulfate	148-163	alpha-L-iduronidase	Homo sapiens	21-25
1679749-0	1991	Heparan sulfate proteoglycan of human colon: partial molecular cloning, cellular expression, and mapping of the gene (HSPG2) to the short arm of human chromosome 1.	Heparitin Sulfate	0-15	heparan sulfate proteoglycan 2	Homo sapiens	118-123
1744977-5	1991	In addition, thrombin inactivation by antithrombin III was accelerated on the endothelial surface, providing strong evidence that heparan sulfate on the surface of endothelial cells exerts a heparin-like activity.	Heparitin Sulfate	130-145	coagulation factor II, thrombin	Homo sapiens	13-21
1744977-5	1991	In addition, thrombin inactivation by antithrombin III was accelerated on the endothelial surface, providing strong evidence that heparan sulfate on the surface of endothelial cells exerts a heparin-like activity.	Heparitin Sulfate	130-145	serpin family C member 1	Homo sapiens	38-54
1744977-6	1991	beta-D-xyloside or cytokine treatments altered the synthesis of heparan sulfate on the endothelial cell surface, resulting in decreased anti-thrombin III binding and diminished heparin-like anticoagulant activity of endothelial cells.	Heparitin Sulfate	64-79	coagulation factor II, thrombin	Homo sapiens	141-149
1654330-6	1991	After heparitinase or nitrous acid treatments the molecular mass of the LPL-binding protein decreased to approximately 50 kDa, suggesting that it contains heparin sulfate chains.	Heparitin Sulfate	155-170	lipoprotein lipase	Bos taurus	72-75
1885587-19	1991	Consistent with the model that binding of lipoprotein lipase to cell surface heparan sulfate is required for lipase degradation, degradation is reduced in chlorate-treated cultures.	Heparitin Sulfate	77-92	lipoprotein lipase	Homo sapiens	42-60
2071579-5	1991	In addition to heparin, SAP bound to heparan sulfate and chondroitin sulfate.	Heparitin Sulfate	37-52	amyloid P component, serum	Homo sapiens	24-27
2071579-7	1991	Gel filtration and sucrose density gradient ultracentrifugation suggested that heparin and heparan sulfate produced a dimer of SAP.	Heparitin Sulfate	91-106	amyloid P component, serum	Homo sapiens	127-130
1655283-2	1991	These activities appear to be mediated by a unique 60 kd protein exposed on the T. cruzi surface, which promotes selective adhesion of trypomastigotes to three ECM components: heparin, heparan sulfate, and collagen.	Heparitin Sulfate	185-200	multimerin 1	Homo sapiens	160-163
1918055-0	1991	Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells.	Heparitin Sulfate	57-72	follistatin	Rattus norvegicus	0-11
1918055-7	1991	These results suggest that follistatin/activin-binding protein binds to heparan sulfate side chains of proteoglycans on the granulosa cell surface to regulate the various actions of activin.	Heparitin Sulfate	72-87	follistatin	Rattus norvegicus	27-38
1940305-6	1991	In the liver, heparan sulfate GAGs were also immunolocalized to the lysosomal compartment of hepatocytes and/or Kupffer cells adjacent to sites of amyloid deposition, suggesting that these cells are involved in HSPG production and/or degradation.	Heparitin Sulfate	14-29	syndecan 2	Mus musculus	211-215
1839430-3	1991	Patients treated with heparan sulphate also showed an increased fibrinolytic activity and a reduced antithrombin III consumption, both of which were statistically significant.	Heparitin Sulfate	22-38	serpin family C member 1	Homo sapiens	100-116
1924289-1	1991	Moesin (membrane-organizing extension spike protein, pronounced mo ez in) has previously been isolated from bovine uterus and characterized as a possible receptor protein for heparan sulfate.	Heparitin Sulfate	175-190	moesin	Bos taurus	0-6
1924289-1	1991	Moesin (membrane-organizing extension spike protein, pronounced mo ez in) has previously been isolated from bovine uterus and characterized as a possible receptor protein for heparan sulfate.	Heparitin Sulfate	175-190	moesin	Bos taurus	8-51
1655335-4	1991	Heparin and heparan sulphate also strongly inhibited human leucocyte elastase activity towards insoluble human lung elastin, as determined by an e.l.i.s.a.	Heparitin Sulfate	12-28	elastin	Homo sapiens	116-123
1655335-9	1991	These results suggest that heparin and heparan sulphate, as components of cellular and basement membranes, are likely to have a role in protecting structural proteins, such as elastin, from the proteolytic activity of human leucocyte elastase.	Heparitin Sulfate	39-55	elastin	Homo sapiens	176-183
1918943-8	1991	It leads to isolation of a proteoglycan with similar electrophoretic mobility in agarose-polyacrylamide gel electrophoresis relative to the independently purified heparan sulfate-containing fibronectin binding proteoglycan from human placenta.	Heparitin Sulfate	163-178	fibronectin 1	Homo sapiens	190-201
1830063-3	1991	When present during the first 24 h of an MLC consisting of MHC disparate murine splenocytes, heparan sulfate had a marked stimulatory effect on the proliferative response to alloantigens.	Heparitin Sulfate	93-108	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	41-44
1830063-5	1991	The stimulatory action of heparan sulfate was mediated, at least in part, by increased production of IL-1, because the increased splenocyte proliferation induced by heparan sulfate was substantially inhibited by anti-murine IL-1 alpha-antibodies.	Heparitin Sulfate	26-41	interleukin 1 complex	Mus musculus	101-105
1830063-5	1991	The stimulatory action of heparan sulfate was mediated, at least in part, by increased production of IL-1, because the increased splenocyte proliferation induced by heparan sulfate was substantially inhibited by anti-murine IL-1 alpha-antibodies.	Heparitin Sulfate	26-41	interleukin 1 alpha	Mus musculus	224-234
1830063-5	1991	The stimulatory action of heparan sulfate was mediated, at least in part, by increased production of IL-1, because the increased splenocyte proliferation induced by heparan sulfate was substantially inhibited by anti-murine IL-1 alpha-antibodies.	Heparitin Sulfate	165-180	interleukin 1 complex	Mus musculus	101-105
1830063-5	1991	The stimulatory action of heparan sulfate was mediated, at least in part, by increased production of IL-1, because the increased splenocyte proliferation induced by heparan sulfate was substantially inhibited by anti-murine IL-1 alpha-antibodies.	Heparitin Sulfate	165-180	interleukin 1 alpha	Mus musculus	224-234
1830063-6	1991	In contrast to these stimulatory effects, when heparan sulfate was added to MLC 48 to 72 h after onset, decreased splenocyte proliferation was observed.	Heparitin Sulfate	47-62	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	76-79
1917344-2	1991	In MPS I (Hurler"s syndrome), reduced activity of alpha-L-iduronidase leads to intralysosomal storage of dermatan and heparan sulfate in various tissues.	Heparitin Sulfate	118-133	alpha-L-iduronidase	Homo sapiens	50-69
1646484-0	1991	Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation.	Heparitin Sulfate	15-30	fibroblast growth factor 2	Homo sapiens	35-39
1926336-1	1991	Basic fibroblast growth factor, (bFGF), promotes the formation of new blood capillaries and is sequestered and protected by binding to heparan sulfate (HS), both on the cell surface and in the extracellular matrix.	Heparitin Sulfate	135-150	fibroblast growth factor 2	Homo sapiens	33-37
1926336-1	1991	Basic fibroblast growth factor, (bFGF), promotes the formation of new blood capillaries and is sequestered and protected by binding to heparan sulfate (HS), both on the cell surface and in the extracellular matrix.	Heparitin Sulfate	152-154	fibroblast growth factor 2	Homo sapiens	33-37
1646484-2	1991	Prevention of binding between cell surface heparan sulfate and bFGF (i) substantially reduces binding of fibroblast growth factor to its cell-surface receptors, (ii) blocks the ability of bFGF to support the growth of Swiss 3T3 fibroblasts, and (iii) induces terminal differentiation of MM14 skeletal muscle cells, which is normally repressed by fibroblast growth factor.	Heparitin Sulfate	43-58	fibroblast growth factor 2	Homo sapiens	188-192
1926061-2	1991	In the present study, we found that thrombin-induced decrease in the accumulation of [35S]sulfate-labeled GAG (35S-GAG) such as heparan sulfate was prevented by antithrombin III (AT III) but not by heparin cofactor II (HC II).	Heparitin Sulfate	128-143	coagulation factor II, thrombin	Bos taurus	36-44
1646484-3	1991	These results indicate that cell surface heparan sulfate is directly involved in bFGF cell signaling.	Heparitin Sulfate	41-56	fibroblast growth factor 2	Homo sapiens	81-85
1926061-2	1991	In the present study, we found that thrombin-induced decrease in the accumulation of [35S]sulfate-labeled GAG (35S-GAG) such as heparan sulfate was prevented by antithrombin III (AT III) but not by heparin cofactor II (HC II).	Heparitin Sulfate	128-143	serpin family D member 1	Bos taurus	219-224
1926061-2	1991	In the present study, we found that thrombin-induced decrease in the accumulation of [35S]sulfate-labeled GAG (35S-GAG) such as heparan sulfate was prevented by antithrombin III (AT III) but not by heparin cofactor II (HC II).	Heparitin Sulfate	128-143	serpin family C member 1	Bos taurus	161-177
1926061-2	1991	In the present study, we found that thrombin-induced decrease in the accumulation of [35S]sulfate-labeled GAG (35S-GAG) such as heparan sulfate was prevented by antithrombin III (AT III) but not by heparin cofactor II (HC II).	Heparitin Sulfate	128-143	serpin family C member 1	Bos taurus	179-185
2017164-3	1991	Heparin sulfate inhibited KAF mitogenic activity on all cell types tested and inhibited the ability of KAF to compete with epidermal growth factor for cell surface binding.	Heparitin Sulfate	0-15	complement factor I	Homo sapiens	26-29
1834236-0	1991	Stimulation of heparan sulphate release from cultured endothelial cells by plasmin.	Heparitin Sulfate	15-31	plasminogen	Bos taurus	75-82
1834236-5	1991	From these results, it was suggested that the local anticoagulant activity on endothelium mediated by the anticoagulant heparan sulphate will be increased by plasmin; the conversion of plasminogen to plasmin may be mediated by plasminogen activators released from thrombin-stimulated endothelial cells.	Heparitin Sulfate	120-136	plasminogen	Bos taurus	158-165
1834236-5	1991	From these results, it was suggested that the local anticoagulant activity on endothelium mediated by the anticoagulant heparan sulphate will be increased by plasmin; the conversion of plasminogen to plasmin may be mediated by plasminogen activators released from thrombin-stimulated endothelial cells.	Heparitin Sulfate	120-136	coagulation factor II, thrombin	Bos taurus	264-272
2017164-3	1991	Heparin sulfate inhibited KAF mitogenic activity on all cell types tested and inhibited the ability of KAF to compete with epidermal growth factor for cell surface binding.	Heparitin Sulfate	0-15	complement factor I	Homo sapiens	103-106
2017164-8	1991	The mitogenic activity of purified AR was also shown to be inhibited by heparin sulfate, and an AR-specific enzyme-linked immunosorbent assay (ELISA) revealed that KAF and AR are antigenically related.	Heparitin Sulfate	72-87	amphiregulin	Homo sapiens	35-37
2017164-10	1991	Our present study demonstrates that one of the growth factors responsible for this autocrine growth (KAF) is similar or identical to AR and that KAF and AR bioactivity can be negatively regulated by heparin sulfate.	Heparitin Sulfate	199-214	complement factor I	Homo sapiens	145-148
2017164-10	1991	Our present study demonstrates that one of the growth factors responsible for this autocrine growth (KAF) is similar or identical to AR and that KAF and AR bioactivity can be negatively regulated by heparin sulfate.	Heparitin Sulfate	199-214	amphiregulin	Homo sapiens	153-155
1711529-4	1991	We have found that bFGF is bound to heparan sulfate (HS) in the ECM and is released in an active form when the ECM-HS is degraded by heparanase expressed by normal and malignant cells (i.e. platelets, neutrophils, lymphoma cells).	Heparitin Sulfate	36-51	fibroblast growth factor 2	Homo sapiens	19-23
2021626-4	1991	The larger species, which migrates as a diffuse band of molecular mass 250-350 kDa on sodium dodecyl sulfate-polyacrylamide electrophoresis gels, is characteristic of the TGF-beta receptor type III, a proteoglycan containing glycosaminoglycan (GAG) chains of chondroitin and heparan sulfate.	Heparitin Sulfate	275-290	transforming growth factor beta receptor 3	Homo sapiens	171-197
1995633-7	1991	These three proteoglycans, C(UI)PG, C(US)PGI, and MPG, had heparan sulfates with estimated Mr values of 32,000, 27,000, and 30,000.	Heparitin Sulfate	59-75	N-methylpurine-DNA glycosylase	Mus musculus	50-53
1905847-5	1991	In thrombin-treated cell layer, both heparan sulfate and the other GAG was significantly decreased at the same degree.	Heparitin Sulfate	37-52	coagulation factor II, thrombin	Bos taurus	3-11
1708391-4	1991	In the binding assay utilizing nitrocellulose as a solid phase to immobilize matrix molecules, syndecan immunoisolated from tooth mesenchyme revealed binding to tenascin, and this interaction was shown to be mediated via heparan sulfate side chains.	Heparitin Sulfate	221-236	tenascin C	Mus musculus	161-169
1901881-1	1991	The present study investigates the regulatory effects of glycosaminoglycans such as heparin and heparan sulfate on T cell proliferation induced by thymic stromal cell monolayer or its derived T cell growth factor (TCGF).	Heparitin Sulfate	96-111	interleukin 2	Homo sapiens	192-212
1901881-1	1991	The present study investigates the regulatory effects of glycosaminoglycans such as heparin and heparan sulfate on T cell proliferation induced by thymic stromal cell monolayer or its derived T cell growth factor (TCGF).	Heparitin Sulfate	96-111	interleukin 2	Homo sapiens	214-218
2007624-0	1991	Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons.	Heparitin Sulfate	65-80	CD44 molecule (Indian blood group)	Homo sapiens	34-38
1901275-0	1991	Interferon-gamma binds to heparan sulfate by a cluster of amino acids located in the C-terminal part of the molecule.	Heparitin Sulfate	26-41	interferon gamma	Homo sapiens	0-16
1901275-1	1991	Using three different approaches (domain mapping with monoclonal antibodies, limited enzymatic digestion and competition with synthetic peptides), we demonstrated that a cluster of basic amino acids on interferon-gamma is involved in its binding to heparan sulfate.	Heparitin Sulfate	249-264	interferon gamma	Homo sapiens	202-218
1901275-3	1991	Once bound to heparin sulfate, IFN-gamma is protected against protease attack.	Heparitin Sulfate	14-29	interferon gamma	Homo sapiens	31-40
1848407-3	1991	This evidence suggests that LPL may be bound ionically to heparan sulfate proteoglycans that are covalently linked to the cell surface of cardiac myocytes by a phosphatidylinositol-glycan membrane anchor; a second pool of LPL may also be bound to proteoglycans attached directly to the myocardial cell surface.	Heparitin Sulfate	58-73	lipoprotein lipase	Rattus norvegicus	28-31
1847668-3	1991	It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.	Heparitin Sulfate	41-56	fibroblast growth factor 2	Mus musculus	158-162
1711529-4	1991	We have found that bFGF is bound to heparan sulfate (HS) in the ECM and is released in an active form when the ECM-HS is degraded by heparanase expressed by normal and malignant cells (i.e. platelets, neutrophils, lymphoma cells).	Heparitin Sulfate	53-55	fibroblast growth factor 2	Homo sapiens	19-23
1711656-7	1991	These results indicate that AD lesions contain bFGF-binding sites and that the chemical substrate for bFGF binding to AD lesions was heparan sulfate.	Heparitin Sulfate	133-148	fibroblast growth factor 2	Homo sapiens	102-106
2024889-5	1991	We have demonstrated that mouse LTA cells synthesize cell surface heparan sulfate proteoglycans with regions of defined monosaccharide sequence that specifically interact with antithrombin (HSPGact).	Heparitin Sulfate	66-81	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	176-188
2024889-7	1991	To examine this issue, we treated LTA cells with ethylmethane sulfonate and then identified mutants that exhibit decreased antithrombin binding to heparan sulfate chains but possess no gross defects in glycosaminoglycan biosynthesis.	Heparitin Sulfate	147-162	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	123-135
1711916-4	1990	Increased production of plasmin may be responsible for the release of soluble complexes of heparan sulfate-bFGF which may be the active form of bFGF.	Heparitin Sulfate	91-106	plasminogen	Homo sapiens	24-31
1934005-1	1991	Heparan sulfate and heparin, new targets for IFN-gamma, protect, relax the cytokine and regulate its activity.	Heparitin Sulfate	0-15	interferon gamma	Homo sapiens	45-54
1934005-4	1991	This specific group of amino acid is also involved in the binding of interferon-gamma to basement membrane or cell surface heparan sulfate.	Heparitin Sulfate	123-138	interferon gamma	Homo sapiens	69-85
1934005-5	1991	Once bound to heparan sulfate, interferon-gamma is protected from proteolytic cleavage and it is suggested that the protein folds in a new relaxed conformation, with increased stability.	Heparitin Sulfate	14-29	interferon gamma	Homo sapiens	31-47
2174463-6	1990	The conditioned media of SC tumors contained very low levels of type IV collagenase (gelatinase) and heparanase (heparan sulfate-specific endo-beta-D-glucuronidase), whereas the media of the cecal wall tumors contained high levels of both.	Heparitin Sulfate	113-128	heparanase	Homo sapiens	64-111
2174463-6	1990	The conditioned media of SC tumors contained very low levels of type IV collagenase (gelatinase) and heparanase (heparan sulfate-specific endo-beta-D-glucuronidase), whereas the media of the cecal wall tumors contained high levels of both.	Heparitin Sulfate	113-128	glucuronidase beta	Homo sapiens	143-163
1832659-1	1991	Quantitative biosynthetic studies with cultures highly enriched for glial fibrillary acidic protein (GFAP+) cells of neonatal mammalian brain demonstrated production of four proteoglycans: hyaluronate (HA), heparan sulphate (HS), chondroitin sulphate (CS), and dermatan sulphate (DS).	Heparitin Sulfate	207-223	glial fibrillary acidic protein	Homo sapiens	68-99
1832659-1	1991	Quantitative biosynthetic studies with cultures highly enriched for glial fibrillary acidic protein (GFAP+) cells of neonatal mammalian brain demonstrated production of four proteoglycans: hyaluronate (HA), heparan sulphate (HS), chondroitin sulphate (CS), and dermatan sulphate (DS).	Heparitin Sulfate	225-227	glial fibrillary acidic protein	Homo sapiens	68-99
1711916-4	1990	Increased production of plasmin may be responsible for the release of soluble complexes of heparan sulfate-bFGF which may be the active form of bFGF.	Heparitin Sulfate	91-106	fibroblast growth factor 2	Homo sapiens	107-111
1711916-4	1990	Increased production of plasmin may be responsible for the release of soluble complexes of heparan sulfate-bFGF which may be the active form of bFGF.	Heparitin Sulfate	91-106	fibroblast growth factor 2	Homo sapiens	144-148
2146882-3	1990	Heparan sulfate also was localized to neurite-containing, nonfibrillar "primitive" plaques that also demonstrated positive BAP immunoreactivity in both AD and DS brains.	Heparitin Sulfate	0-15	SIL1 nucleotide exchange factor	Homo sapiens	123-126
2213021-7	1990	(d) The levels of HS labeled with [35S]sulfate during the last 48 h of the culture were 1.5- to twofold higher in the NGF-treated cultures than in the respective controls at any time.	Heparitin Sulfate	18-20	nerve growth factor	Rattus norvegicus	118-121
2220820-1	1990	The lysosomal hydrolase alpha-L-iduronidase (IDUA) is one of the enzymes in the metabolic pathway responsible for the degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate.	Heparitin Sulfate	156-171	alpha-L-iduronidase	Homo sapiens	24-43
2220820-1	1990	The lysosomal hydrolase alpha-L-iduronidase (IDUA) is one of the enzymes in the metabolic pathway responsible for the degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate.	Heparitin Sulfate	156-171	alpha-L-iduronidase	Homo sapiens	45-49
2122463-1	1990	Iduronate 2-sulfatase (IDS, EC 3.1.6.13) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate.	Heparitin Sulfate	86-101	iduronate 2-sulfatase	Homo sapiens	0-21
1700081-0	1990	Inhibition of agrin-induced acetylcholine-receptor aggregation by heparin, heparan sulfate, and other polyanions.	Heparitin Sulfate	75-90	agrin	Homo sapiens	14-19
1700081-2	1990	We found that heparin, heparan sulfate, and a wide variety of other polyanions also inhibited agrin-induced AChR aggregation.	Heparitin Sulfate	23-38	agrin	Homo sapiens	94-99
2122463-1	1990	Iduronate 2-sulfatase (IDS, EC 3.1.6.13) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate.	Heparitin Sulfate	86-101	iduronate 2-sulfatase	Homo sapiens	23-26
2282507-4	1990	Sulfated glycosaminoglycans as heparan sulfate and heparin extracted the asymmetric AChE from the synaptic basal lamina.	Heparitin Sulfate	31-46	acetylcholinesterase	Rattus norvegicus	84-88
1705486-7	1990	Our results indicate that bFGF is bound to heparan sulfate (HS) in the ECM and is released in an active form when the ECM-HS is degraded by cellular heparanase.	Heparitin Sulfate	43-58	fibroblast growth factor 2	Homo sapiens	26-30
1705486-7	1990	Our results indicate that bFGF is bound to heparan sulfate (HS) in the ECM and is released in an active form when the ECM-HS is degraded by cellular heparanase.	Heparitin Sulfate	60-62	fibroblast growth factor 2	Homo sapiens	26-30
2144604-6	1990	In contrast, translocation of cells through artificial matrices mediated by T cell FN is a biophysical process dependent on interactions between surface heparan sulfates on responding cells and FN amino-terminal heparin-binding and gelatin-binding domains.	Heparitin Sulfate	153-169	fibronectin 1	Mus musculus	83-85
2170425-3	1990	Heparan sulfates affected the diffusion of 125I-bFGF in a manner similar to, though less pronounced than, heparin.	Heparitin Sulfate	0-16	fibroblast growth factor 2	Bos taurus	48-52
1698204-1	1990	Using the high-iron diamine thiocarbohydrazide silver proteinate (HID-TCH-SP) staining technique and enzymatic digestion, we investigated the ultrastructural distribution pattern of heparan sulfate side chains of heparan sulfate proteoglycan (HSPG) in various basement membranes (nerve, capillary, oral epithelial, muscle, and dental basement membranes).	Heparitin Sulfate	182-197	CD44 molecule (Indian blood group)	Homo sapiens	213-241
2202741-3	1990	Incorporation of [35S]sulfate into heparan sulfate on cultured porcine aortic endothelial cells was suppressed by human recombinant interleukin-1 beta (rIL-1 beta) or tumor necrosis factor alpha (rTNF alpha) in a dose- and time-dependent manner with little effect on cell number, protein content, and [3H]leucine incorporation of cells.	Heparitin Sulfate	35-50	interleukin 1 beta	Homo sapiens	132-150
2387324-10	1990	An increase in cell-associated heparan sulfate, however, was observed in TGF-beta-treated cells.	Heparitin Sulfate	31-46	transforming growth factor, beta 1	Rattus norvegicus	73-81
2226352-9	1990	In the cell-matrix fraction, TGF-beta increased the proportion of heparan sulfate that was membrane bound as well as the proportion of dermatan sulfate in the intracellular compartment.	Heparitin Sulfate	66-81	transforming growth factor beta 1	Homo sapiens	29-37
2202741-3	1990	Incorporation of [35S]sulfate into heparan sulfate on cultured porcine aortic endothelial cells was suppressed by human recombinant interleukin-1 beta (rIL-1 beta) or tumor necrosis factor alpha (rTNF alpha) in a dose- and time-dependent manner with little effect on cell number, protein content, and [3H]leucine incorporation of cells.	Heparitin Sulfate	35-50	tumor necrosis factor	Rattus norvegicus	152-194
2202741-4	1990	Maximal inhibition was achieved by incubation of cells with 100 ng/ml of rIL-1 beta or 5 ng/ml of rTNF alpha for 12-24 hours, resulting in a reduction of the synthesis of heparan sulfate on the cell surface by approximately 50%.	Heparitin Sulfate	171-186	interleukin 1 beta	Rattus norvegicus	73-83
2202741-4	1990	Maximal inhibition was achieved by incubation of cells with 100 ng/ml of rIL-1 beta or 5 ng/ml of rTNF alpha for 12-24 hours, resulting in a reduction of the synthesis of heparan sulfate on the cell surface by approximately 50%.	Heparitin Sulfate	171-186	tumor necrosis factor	Rattus norvegicus	98-108
2373688-4	1990	These cells produce hyaluronan (Mr approximately 1,400,000; a chondroitin sulfate PG (CSPG), Mr approximately 600,000; a heparan sulfate PG (HSPG), Mr approximately 400,000; and two dermatan sulfate PGs with Mr approximately 270,000 (biglycan, PG I) and Mr approximately 135,000 (decorin, PG II) that distribute between the medium and cell layer.	Heparitin Sulfate	121-136	syndecan 2	Homo sapiens	141-145
1696913-4	1990	Heparin or heparan sulfate are shown here to modulate the conformation of clipped vitronectin at physiological pH, exposing Ser378 and allowing its stoichiometric phosphorylation by the kinase.	Heparitin Sulfate	11-26	vitronectin	Homo sapiens	82-93
1696913-5	1990	At this pH the two-chain form of vitronectin in plasma exhibits a higher affinity for heparin, and behaves as a flexible molecule, which can conformationally respond to heparin and heparan sulfate, effectors involved in vitronectin function.	Heparitin Sulfate	181-196	vitronectin	Homo sapiens	33-44
1696913-5	1990	At this pH the two-chain form of vitronectin in plasma exhibits a higher affinity for heparin, and behaves as a flexible molecule, which can conformationally respond to heparin and heparan sulfate, effectors involved in vitronectin function.	Heparitin Sulfate	181-196	vitronectin	Homo sapiens	220-231
1974403-2	1990	Arteparon (GAGPS), heparin, heparan sulfate, chondroitin sulfate, and dextran sulfate, but not dextran, inhibited HLE-mediated hydrolysis of succinyl-ala2-val-pNA.	Heparitin Sulfate	28-43	elastase, neutrophil expressed	Homo sapiens	114-117
2143417-1	1990	Heparin sulfate and the less sulfated glycosaminoglycan heparan sulfate enhance human plasminogen (Pg) conversion to plasmin by tissue-type plasminogen activator (t-PA).	Heparitin Sulfate	0-15	plasminogen	Homo sapiens	86-93
2143417-1	1990	Heparin sulfate and the less sulfated glycosaminoglycan heparan sulfate enhance human plasminogen (Pg) conversion to plasmin by tissue-type plasminogen activator (t-PA).	Heparitin Sulfate	0-15	plasminogen activator, tissue type	Homo sapiens	128-161
2143417-1	1990	Heparin sulfate and the less sulfated glycosaminoglycan heparan sulfate enhance human plasminogen (Pg) conversion to plasmin by tissue-type plasminogen activator (t-PA).	Heparitin Sulfate	0-15	plasminogen activator, tissue type	Homo sapiens	163-167
2143417-1	1990	Heparin sulfate and the less sulfated glycosaminoglycan heparan sulfate enhance human plasminogen (Pg) conversion to plasmin by tissue-type plasminogen activator (t-PA).	Heparitin Sulfate	56-71	plasminogen	Homo sapiens	86-93
2143417-1	1990	Heparin sulfate and the less sulfated glycosaminoglycan heparan sulfate enhance human plasminogen (Pg) conversion to plasmin by tissue-type plasminogen activator (t-PA).	Heparitin Sulfate	56-71	plasminogen activator, tissue type	Homo sapiens	128-161
2143417-1	1990	Heparin sulfate and the less sulfated glycosaminoglycan heparan sulfate enhance human plasminogen (Pg) conversion to plasmin by tissue-type plasminogen activator (t-PA).	Heparitin Sulfate	56-71	plasminogen activator, tissue type	Homo sapiens	163-167
2186947-10	1990	On the other hand, an antibody to an integrin, as well as heparan sulfate, alleviates the antichondrogenic effects of both fibronectin and ectoderm-conditioned medium.	Heparitin Sulfate	58-73	fibronectin 1	Homo sapiens	123-134
2137090-0	1990	Proteoglycan synthesis by cultured liver endothelium: the role of membrane-associated heparan sulfate in transferrin binding.	Heparitin Sulfate	86-101	transferrin	Homo sapiens	105-116
1969657-4	1990	Syndecan consists of chondroitin sulfate and heparan sulphate chains linked to a 31 kilodalton (kDa) integral membrane protein.	Heparitin Sulfate	45-61	syndecan 1	Homo sapiens	0-8
2137829-0	1990	Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.	Heparitin Sulfate	42-57	fibroblast growth factor 2	Bos taurus	11-41
33232799-0	2021	BMP6 binding to heparin and heparan sulfate is mediated by N-terminal and C-terminal clustered basic residues.	Heparitin Sulfate	28-43	bone morphogenetic protein 6	Cricetulus griseus	0-4
33587773-1	2021	BACKGROUND: Heparanase (HPSE) is the only known mammalian enzyme that can degrade heparan sulfate.	Heparitin Sulfate	82-97	heparanase	Homo sapiens	12-22
33587773-1	2021	BACKGROUND: Heparanase (HPSE) is the only known mammalian enzyme that can degrade heparan sulfate.	Heparitin Sulfate	82-97	heparanase	Homo sapiens	24-28
33794550-1	2021	Heparanase, the only mammalian enzyme known to degrade heparan sulfate chains, affects the hemostatic system through several mechanisms.	Heparitin Sulfate	55-70	heparanase	Homo sapiens	0-10
33794550-4	2021	Tissue factor pathway inhibitor and the strongest physiological anticoagulant antithrombin are attached to the endothelial cell surface by heparan sulfate.	Heparitin Sulfate	139-154	serpin family C member 1	Homo sapiens	78-90
33810567-3	2021	Syndecan-4, a transmembrane heparan sulfate proteoglycan, is a central mediator of cell adhesion, migration and proliferation.	Heparitin Sulfate	28-43	syndecan 4	Homo sapiens	0-10
33771558-3	2021	These interactions can be further fine-tuned through changes in the availability of the VEGF binding sites on fibronectin, regulated by conformational changes induced by heparin and heparan sulfate chains within the extracellular matrix.	Heparitin Sulfate	182-197	vascular endothelial growth factor A	Homo sapiens	88-92
33771558-3	2021	These interactions can be further fine-tuned through changes in the availability of the VEGF binding sites on fibronectin, regulated by conformational changes induced by heparin and heparan sulfate chains within the extracellular matrix.	Heparitin Sulfate	182-197	fibronectin 1	Homo sapiens	110-121
2106874-11	1990	It is suggested that tissue EC-SOD is secreted by a few well-dispersed cell types, such as fibroblasts and glia cells, to diffuse subsequently around and reversibly bind to heparan sulphate proteoglycan ligands in the glycocalyx of the surface of most tissue cell types and in the interstitial matrix.	Heparitin Sulfate	173-189	superoxide dismutase 3	Homo sapiens	28-34
2302416-2	1990	Binding was linear up to a concentration of 0.5 microgram/ml (10 nM) enzyme used in this study, and equilibrium was achieved after 2 h of incubation with bovine 125I-LPL at 4 degrees C. Heparin and heparan sulfate effectively inhibited the binding of LPL to extracellular-matrix-coated plates; chondroitin sulfate had no effect, while high concentrations of dermatan sulfate or keratan sulfate inhibited binding of LPL to extracellular matrix by only 40%.	Heparitin Sulfate	198-213	lipoprotein lipase	Bos taurus	166-169
2300584-9	1990	We suggest that in situations when fatty acids are generated more rapidly by LPL than they are used by the local tissue, they cause dissociation of the enzyme from its binding to endothelial heparin sulfate and are themselves released into circulation.	Heparitin Sulfate	191-206	lipoprotein lipase	Bos taurus	77-80
33772011-3	2021	Sulf2, an extracellular endosulfatase, modulates the signaling microenvironment by editing the pattern of sulfation on heparan sulfate proteoglycans.	Heparitin Sulfate	119-134	sulfatase 2	Homo sapiens	0-5
33809984-3	2021	Results demonstrated that in addition to the heparan sulfate proteoglycan, perlecan, all components of the PSPN Complex were degraded by MMP-7.	Heparitin Sulfate	45-60	matrix metallopeptidase 7	Homo sapiens	137-142
33232799-3	2021	The BMP2/4 subfamily has been deeply characterized to have a N-terminal heparin/HS binding domain (HBD), whose basic residues contact the sulfate groups on heparin and HS.	Heparitin Sulfate	80-82	bone morphogenetic protein 2	Cricetulus griseus	4-10
33236989-6	2020	We demonstrate that Wnt3 spreads extracellularly and interacts with heparan sulfate proteoglycans (HSPG).	Heparitin Sulfate	68-83	wingless-type MMTV integration site family, member 3	Danio rerio	20-24
8510409-5	1993	While in control cells the cell-associated heparan sulfate accounts for about 30% of the total glycosaminoglycans under the influence of bFGF the HS percentage increases to approximately 60%.	Heparitin Sulfate	43-58	fibroblast growth factor 2	Bos taurus	137-141
33234593-0	2021	A quantitative method to detect non-antithrombin-binding 3-O-sulfated units in heparan sulfate.	Heparitin Sulfate	79-94	serpin family C member 1	Homo sapiens	36-48
34678489-4	2022	These receptors include heparan sulfate (HS), herpesvirus entry mediator (HVEM), and nectin-1/-2, 3-O-sulfated heparan sulfate (3-OS HS).	Heparitin Sulfate	111-126	nectin cell adhesion molecule 1	Homo sapiens	85-93
34748756-2	2022	Glypican 4 (Gpc4) belongs to the heparan sulfate proteoglycan family, which play an important role in axon guidance and excitatory synapse formation.	Heparitin Sulfate	33-48	glypican 4	Mus musculus	0-10
34748756-2	2022	Glypican 4 (Gpc4) belongs to the heparan sulfate proteoglycan family, which play an important role in axon guidance and excitatory synapse formation.	Heparitin Sulfate	33-48	glypican 4	Homo sapiens	12-16
34246414-4	2022	Because it is modular, the assay can monitor the impact of different cellular components, such as heparan sulfate, lipids, and membrane proteins on the RBD-ACE2 interaction and it can be extended to the full-length spike protein.	Heparitin Sulfate	98-113	angiotensin converting enzyme 2	Homo sapiens	156-160
34270745-3	2021	Recent biochemical work showed that heparan sulfate (HS), an unbranched sulfated glycan, acts as a ligand for and activates ALK.	Heparitin Sulfate	36-51	ALK receptor tyrosine kinase	Homo sapiens	124-127
34657240-5	2022	Therefore, we speculated that DAL-1/4.1B might promote the uptake of exosomes through the heparan sulfate proteoglycans (HSPGs) pathway.	Heparitin Sulfate	90-105	erythrocyte membrane protein band 4.1 like 3	Homo sapiens	36-40
34270745-3	2021	Recent biochemical work showed that heparan sulfate (HS), an unbranched sulfated glycan, acts as a ligand for and activates ALK.	Heparitin Sulfate	53-55	ALK receptor tyrosine kinase	Homo sapiens	124-127
34931184-3	2021	N released by SARS-CoV-2 infected cells or N-expressing transfected cells binds to neighboring cells by electrostatic high-affinity binding to heparan sulfate and heparin, but not other sulfated glycosaminoglycans.	Heparitin Sulfate	143-158	nucleocapsid phosphoprotein	Severe acute respiratory syndrome coronavirus 2	0-1
34324645-5	2021	Fractones in the SVZ of Sulf1/2 DKO mice showed immunoreactivity for the HS epitope, suggesting higher 6-O sulfation.	Heparitin Sulfate	73-75	sulfatase 1	Mus musculus	24-31
34743814-0	2021	SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate.	Heparitin Sulfate	91-106	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	11-16
34743814-3	2021	Heparan sulfate (HS)/heparin, a key factor in coagulation process, was found to bind SARS-CoV-2 S protein with high affinity.	Heparitin Sulfate	0-15	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	96-97
34743814-3	2021	Heparan sulfate (HS)/heparin, a key factor in coagulation process, was found to bind SARS-CoV-2 S protein with high affinity.	Heparitin Sulfate	17-19	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	96-97
34743814-4	2021	Herein, we found that the S protein can competitively inhibit the bindings of antithrombin and heparin cofactor II to heparin/HS, causing abnormal increase in thrombin activity.	Heparitin Sulfate	126-128	serpin family C member 1	Homo sapiens	78-90
34743814-4	2021	Herein, we found that the S protein can competitively inhibit the bindings of antithrombin and heparin cofactor II to heparin/HS, causing abnormal increase in thrombin activity.	Heparitin Sulfate	126-128	coagulation factor II, thrombin	Homo sapiens	159-167
34931195-3	2021	N released by SARS-CoV-2 infected cells or N-expressing transfected cells binds to neighboring cells by electrostatic high-affinity binding to heparan sulfate and heparin, but not other sulfated glycosaminoglycans.	Heparitin Sulfate	143-158	nucleocapsid phosphoprotein	Severe acute respiratory syndrome coronavirus 2	0-1
34931195-3	2021	N released by SARS-CoV-2 infected cells or N-expressing transfected cells binds to neighboring cells by electrostatic high-affinity binding to heparan sulfate and heparin, but not other sulfated glycosaminoglycans.	Heparitin Sulfate	143-158	nucleocapsid phosphoprotein	Severe acute respiratory syndrome coronavirus 2	43-44
34931184-3	2021	N released by SARS-CoV-2 infected cells or N-expressing transfected cells binds to neighboring cells by electrostatic high-affinity binding to heparan sulfate and heparin, but not other sulfated glycosaminoglycans.	Heparitin Sulfate	143-158	nucleocapsid phosphoprotein	Severe acute respiratory syndrome coronavirus 2	43-44
34946571-7	2021	Thus, by means of computational molecular modelling, docking and dynamics, we also provide a characterization at an atomic level of the binding modes of the Tat/heparin interaction, with heparin herein used as a structural analogue of the heparan sulfate chains of syndecan-1.	Heparitin Sulfate	239-254	syndecan 1	Homo sapiens	265-275
34956317-5	2021	The disease results mainly from heterozygous loss-of-function alterations in the EXT1 or EXT2 genes, encoding Golgi-associated glycosyltransferases, responsible for heparan sulfate biosynthesis.	Heparitin Sulfate	165-180	exostosin glycosyltransferase 1	Homo sapiens	81-85
34956317-5	2021	The disease results mainly from heterozygous loss-of-function alterations in the EXT1 or EXT2 genes, encoding Golgi-associated glycosyltransferases, responsible for heparan sulfate biosynthesis.	Heparitin Sulfate	165-180	exostosin glycosyltransferase 2	Homo sapiens	89-93
34830227-5	2021	Elevated levels of soluble heparan sulfate, hyaluronic acid and syndecan-1 were measured in blood samples following ricin intoxication, indicating that the vascular glycocalyx of both mice and swine underwent extensive damage.	Heparitin Sulfate	27-42	ricin	Ricinus communis	116-121
34939110-0	2022	Complex modulation of cytokine-induced alpha-synuclein aggregation by glypican-1-derived heparan sulfate in neural cells.	Heparitin Sulfate	89-104	synuclein alpha	Homo sapiens	39-54
34939110-0	2022	Complex modulation of cytokine-induced alpha-synuclein aggregation by glypican-1-derived heparan sulfate in neural cells.	Heparitin Sulfate	89-104	glypican 1	Homo sapiens	70-80
34939110-2	2022	The cytokines TNF-alpha, IL-1beta and IL-6 induce accumulation of degradation products of the amyloid precursor protein (APP) combined with heparan sulfate (HS) chains released from glypican-1 (Gpc-1) by NO-dependent cleavage.	Heparitin Sulfate	140-155	tumor necrosis factor	Homo sapiens	14-23
34939110-2	2022	The cytokines TNF-alpha, IL-1beta and IL-6 induce accumulation of degradation products of the amyloid precursor protein (APP) combined with heparan sulfate (HS) chains released from glypican-1 (Gpc-1) by NO-dependent cleavage.	Heparitin Sulfate	140-155	interleukin 1 alpha	Homo sapiens	25-33
34939110-2	2022	The cytokines TNF-alpha, IL-1beta and IL-6 induce accumulation of degradation products of the amyloid precursor protein (APP) combined with heparan sulfate (HS) chains released from glypican-1 (Gpc-1) by NO-dependent cleavage.	Heparitin Sulfate	140-155	interleukin 6	Homo sapiens	38-42
34939110-2	2022	The cytokines TNF-alpha, IL-1beta and IL-6 induce accumulation of degradation products of the amyloid precursor protein (APP) combined with heparan sulfate (HS) chains released from glypican-1 (Gpc-1) by NO-dependent cleavage.	Heparitin Sulfate	140-155	glypican 1	Homo sapiens	182-192
34939110-2	2022	The cytokines TNF-alpha, IL-1beta and IL-6 induce accumulation of degradation products of the amyloid precursor protein (APP) combined with heparan sulfate (HS) chains released from glypican-1 (Gpc-1) by NO-dependent cleavage.	Heparitin Sulfate	140-155	glypican 1	Homo sapiens	194-199
34917099-5	2021	This interaction between KIR3DS1 and heparan sulfate was confirmed via surface plasmon resonance, and removal of heparan sulfate proteoglycans from cell surfaces abolished KIR3DS1-Fc binding.	Heparitin Sulfate	113-128	killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1	Homo sapiens	172-179
34917099-6	2021	Testing of additional KIR-Fc constructs demonstrated that KIR family members containing a D0 domain (KIR3DS1, KIR3DL1, KIR3DL2, KIR2DL4, and KIR2DL5) bound to heparan sulfate, while those without a D0 domain (KIR2DL1, KIR2DL2, KIR2DL3, and KIR2DS4) did not.	Heparitin Sulfate	159-174	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	22-25
34917099-6	2021	Testing of additional KIR-Fc constructs demonstrated that KIR family members containing a D0 domain (KIR3DS1, KIR3DL1, KIR3DL2, KIR2DL4, and KIR2DL5) bound to heparan sulfate, while those without a D0 domain (KIR2DL1, KIR2DL2, KIR2DL3, and KIR2DS4) did not.	Heparitin Sulfate	159-174	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	58-61
34917099-6	2021	Testing of additional KIR-Fc constructs demonstrated that KIR family members containing a D0 domain (KIR3DS1, KIR3DL1, KIR3DL2, KIR2DL4, and KIR2DL5) bound to heparan sulfate, while those without a D0 domain (KIR2DL1, KIR2DL2, KIR2DL3, and KIR2DS4) did not.	Heparitin Sulfate	159-174	killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1	Homo sapiens	101-108
34917099-6	2021	Testing of additional KIR-Fc constructs demonstrated that KIR family members containing a D0 domain (KIR3DS1, KIR3DL1, KIR3DL2, KIR2DL4, and KIR2DL5) bound to heparan sulfate, while those without a D0 domain (KIR2DL1, KIR2DL2, KIR2DL3, and KIR2DS4) did not.	Heparitin Sulfate	159-174	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	110-117
34917099-6	2021	Testing of additional KIR-Fc constructs demonstrated that KIR family members containing a D0 domain (KIR3DS1, KIR3DL1, KIR3DL2, KIR2DL4, and KIR2DL5) bound to heparan sulfate, while those without a D0 domain (KIR2DL1, KIR2DL2, KIR2DL3, and KIR2DS4) did not.	Heparitin Sulfate	159-174	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2	Homo sapiens	119-126
34917099-6	2021	Testing of additional KIR-Fc constructs demonstrated that KIR family members containing a D0 domain (KIR3DS1, KIR3DL1, KIR3DL2, KIR2DL4, and KIR2DL5) bound to heparan sulfate, while those without a D0 domain (KIR2DL1, KIR2DL2, KIR2DL3, and KIR2DS4) did not.	Heparitin Sulfate	159-174	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	128-135
34917099-6	2021	Testing of additional KIR-Fc constructs demonstrated that KIR family members containing a D0 domain (KIR3DS1, KIR3DL1, KIR3DL2, KIR2DL4, and KIR2DL5) bound to heparan sulfate, while those without a D0 domain (KIR2DL1, KIR2DL2, KIR2DL3, and KIR2DS4) did not.	Heparitin Sulfate	159-174	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A	Homo sapiens	141-148
34900335-2	2021	In this report, syndecan-4, a heparan sulfate containing proteoglycan, was investigated as a unique molecule for use in scaffold functionalization.	Heparitin Sulfate	30-45	syndecan 4	Homo sapiens	16-26
34806811-1	2022	Mucopolysaccharidosis type IIIB is a rare autosomal recessive disorder characterized by deficiency of the enzyme N-acetyl-alpha-d-glucosaminidase (NAGLU), caused by biallelic pathogenic variants in the NAGLU gene, which leads to storage of heparan sulfate and a series of clinical consequences which hallmark is neurodegeneration.	Heparitin Sulfate	240-255	N-acetyl-alpha-glucosaminidase	Homo sapiens	202-207
34917926-6	2021	The activity of the heparan sulfate (HS) specific glucuronidase Heparanase-1 (Hpa-1) is elevated in sepsis, resulting in shedding of heparan sulfate (HS), a main GAG of the eGC.	Heparitin Sulfate	20-35	heparanase	Homo sapiens	64-76
34917926-6	2021	The activity of the heparan sulfate (HS) specific glucuronidase Heparanase-1 (Hpa-1) is elevated in sepsis, resulting in shedding of heparan sulfate (HS), a main GAG of the eGC.	Heparitin Sulfate	20-35	heparanase	Homo sapiens	78-83
34917926-6	2021	The activity of the heparan sulfate (HS) specific glucuronidase Heparanase-1 (Hpa-1) is elevated in sepsis, resulting in shedding of heparan sulfate (HS), a main GAG of the eGC.	Heparitin Sulfate	133-148	heparanase	Homo sapiens	64-76
34917926-6	2021	The activity of the heparan sulfate (HS) specific glucuronidase Heparanase-1 (Hpa-1) is elevated in sepsis, resulting in shedding of heparan sulfate (HS), a main GAG of the eGC.	Heparitin Sulfate	133-148	heparanase	Homo sapiens	78-83
33560940-0	2021	The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor.	Heparitin Sulfate	126-141	lactotransferrin	Bos taurus	35-46
34917099-4	2021	To identify these non-HLA ligands, we developed a magnetic enrichment-based genome-wide CRISPR/Cas9 knock-out screen approach, and identified enzymes involved in the biosynthesis of heparan sulfate as crucial for the binding of KIR3DS1-Fc to K562 cells.	Heparitin Sulfate	182-197	killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1	Homo sapiens	228-235
34917099-5	2021	This interaction between KIR3DS1 and heparan sulfate was confirmed via surface plasmon resonance, and removal of heparan sulfate proteoglycans from cell surfaces abolished KIR3DS1-Fc binding.	Heparitin Sulfate	37-52	killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1	Homo sapiens	25-32
34806811-1	2022	Mucopolysaccharidosis type IIIB is a rare autosomal recessive disorder characterized by deficiency of the enzyme N-acetyl-alpha-d-glucosaminidase (NAGLU), caused by biallelic pathogenic variants in the NAGLU gene, which leads to storage of heparan sulfate and a series of clinical consequences which hallmark is neurodegeneration.	Heparitin Sulfate	240-255	N-acetyl-alpha-glucosaminidase	Homo sapiens	147-152
34411609-1	2021	Mucopolysaccharidosis type IIIB (MPS IIIB) is a lysosomal disease caused by mutations in the NAGLU gene encoding alpha-N-acetylglucosaminidase (NAGLU) which degrades heparan sulfate in lysosomes.	Heparitin Sulfate	166-181	N-acetyl-alpha-glucosaminidase	Homo sapiens	0-31
34715561-2	2021	We recently identified how a loss-of-function mutation in the glycan sulfating enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1; involved in heparan sulfate biosynthesis) targeted to antigen presenting cells (APCs) may augment acquired anti-tumor T cell immune mechanisms.	Heparitin Sulfate	141-156	N-deacetylase and N-sulfotransferase 1	Homo sapiens	86-120
34715561-2	2021	We recently identified how a loss-of-function mutation in the glycan sulfating enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1; involved in heparan sulfate biosynthesis) targeted to antigen presenting cells (APCs) may augment acquired anti-tumor T cell immune mechanisms.	Heparitin Sulfate	141-156	N-deacetylase and N-sulfotransferase 1	Homo sapiens	122-127
34693552-1	2022	Heparanase is the only mammalian enzyme capable of cleaving heparan sulfate, a glycosaminoglycan of the extracellular matrix and cell surfaces.	Heparitin Sulfate	60-75	heparanase	Homo sapiens	0-10
34692689-2	2021	We have previously shown that age/disease mediated matrix stiffness inhibits the glycocalyx glycosaminoglycan heparan sulfate and its core protein Glypican 1 in human umbilical vein endothelial cells, rat fat pad endothelial cells and in a mouse model of age-mediated stiffness.	Heparitin Sulfate	110-125	glypican 1	Homo sapiens	147-157
34858858-5	2021	This review addresses the regulatory mechanisms underlying HS biosynthesis, with a particular focus on the catalytic activity of the enzymes responsible for HS glycan sequences and sulfation motifs, namely D-Glucuronyl C5-Epimerase, N- and O-Sulfotransferases.	Heparitin Sulfate	59-61	glucuronic acid epimerase	Homo sapiens	206-231
34815940-1	2021	Background: Hereditary Multiple Exostoses (HME) is a rare autosomal disorder characterized by the presence of multiple exostoses (osteochondromas) caused by a heterozygous loss of function mutation in EXT1 or EXT2; genes involved in heparan sulfate (HS) chain elongation.	Heparitin Sulfate	233-248	exostosin glycosyltransferase 1	Homo sapiens	201-205
34815940-1	2021	Background: Hereditary Multiple Exostoses (HME) is a rare autosomal disorder characterized by the presence of multiple exostoses (osteochondromas) caused by a heterozygous loss of function mutation in EXT1 or EXT2; genes involved in heparan sulfate (HS) chain elongation.	Heparitin Sulfate	233-248	exostosin glycosyltransferase 2	Homo sapiens	209-213
34825135-0	2021	A heparan-sulfate-bearing syndecan-1 glycoform is a distinct surface marker for intra-tumoral myeloid-derived suppressor cells.	Heparitin Sulfate	2-17	syndecan 1	Homo sapiens	26-36
34699015-0	2022	Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin.	Heparitin Sulfate	30-45	furin, paired basic amino acid cleaving enzyme	Homo sapiens	104-109
34699015-5	2022	Here we demonstrated that Furin is a novel heparin/heparan sulfate binding protein by the use of biochemical and genetic assays.	Heparitin Sulfate	51-66	furin, paired basic amino acid cleaving enzyme	Homo sapiens	26-31
34699015-10	2022	These data could advance our understanding of the working mechanism of Furin and will benefit the Furin based drug discovery such as inhibitors targeting the interaction between heparan sulfate and Furin for inhibition of viral infection.	Heparitin Sulfate	178-193	furin, paired basic amino acid cleaving enzyme	Homo sapiens	71-76
34699015-10	2022	These data could advance our understanding of the working mechanism of Furin and will benefit the Furin based drug discovery such as inhibitors targeting the interaction between heparan sulfate and Furin for inhibition of viral infection.	Heparitin Sulfate	178-193	furin, paired basic amino acid cleaving enzyme	Homo sapiens	98-103
34699015-10	2022	These data could advance our understanding of the working mechanism of Furin and will benefit the Furin based drug discovery such as inhibitors targeting the interaction between heparan sulfate and Furin for inhibition of viral infection.	Heparitin Sulfate	178-193	furin, paired basic amino acid cleaving enzyme	Homo sapiens	198-203
34351732-1	2021	Heparan sulfate (HS) 3-O-sulfotransferase isoform 4 (3-OST-4) is a specialized carbohydrate sulfotransferase participating in the biosynthesis of heparan sulfate.	Heparitin Sulfate	0-15	heparan sulfate-glucosamine 3-sulfotransferase 4	Homo sapiens	53-60
34351732-1	2021	Heparan sulfate (HS) 3-O-sulfotransferase isoform 4 (3-OST-4) is a specialized carbohydrate sulfotransferase participating in the biosynthesis of heparan sulfate.	Heparitin Sulfate	146-161	heparan sulfate-glucosamine 3-sulfotransferase 4	Homo sapiens	53-60
34648606-6	2021	These results were confirmed by a genetic approach targeting EXTL3, a key factor in the HS biosynthesis pathway, as well as by enzymatic and chemical methods.	Heparitin Sulfate	88-90	exostosin like glycosyltransferase 3	Homo sapiens	61-66
34648606-7	2021	Interestingly, a single point mutation within GP1 (S153F or Y155H) of WE HPI is sufficient for the switch from DAG1 to HS binding.	Heparitin Sulfate	119-121	GTP binding protein 1	Homo sapiens	46-49
34646364-5	2021	Glypican-1 (GPC-1) is a heparan sulfate proteoglycan that is expressed in a variety of solid tumors, but whose expression is restricted in normal adult tissue.	Heparitin Sulfate	24-39	glypican 1	Homo sapiens	0-10
34646364-5	2021	Glypican-1 (GPC-1) is a heparan sulfate proteoglycan that is expressed in a variety of solid tumors, but whose expression is restricted in normal adult tissue.	Heparitin Sulfate	24-39	glypican 1	Homo sapiens	12-17
34411609-1	2021	Mucopolysaccharidosis type IIIB (MPS IIIB) is a lysosomal disease caused by mutations in the NAGLU gene encoding alpha-N-acetylglucosaminidase (NAGLU) which degrades heparan sulfate in lysosomes.	Heparitin Sulfate	166-181	N-acetyl-alpha-glucosaminidase	Homo sapiens	33-41
34411609-1	2021	Mucopolysaccharidosis type IIIB (MPS IIIB) is a lysosomal disease caused by mutations in the NAGLU gene encoding alpha-N-acetylglucosaminidase (NAGLU) which degrades heparan sulfate in lysosomes.	Heparitin Sulfate	166-181	N-acetyl-alpha-glucosaminidase	Homo sapiens	93-98
34411609-1	2021	Mucopolysaccharidosis type IIIB (MPS IIIB) is a lysosomal disease caused by mutations in the NAGLU gene encoding alpha-N-acetylglucosaminidase (NAGLU) which degrades heparan sulfate in lysosomes.	Heparitin Sulfate	166-181	N-acetyl-alpha-glucosaminidase	Homo sapiens	113-142
34411609-1	2021	Mucopolysaccharidosis type IIIB (MPS IIIB) is a lysosomal disease caused by mutations in the NAGLU gene encoding alpha-N-acetylglucosaminidase (NAGLU) which degrades heparan sulfate in lysosomes.	Heparitin Sulfate	166-181	N-acetyl-alpha-glucosaminidase	Homo sapiens	144-149
34405855-0	2021	Decoding the consecutive lysosomal degradation of 3-O-sulfate containing heparan sulfate by Arylsulfatase G (ARSG).	Heparitin Sulfate	73-88	arylsulfatase G	Mus musculus	92-107
34411733-2	2021	Heparan sulfate proteoglycans (HSPG) participate in nitric oxide (NO) and calcium signaling, key regulators of vascular function.	Heparitin Sulfate	0-15	syndecan 2	Mus musculus	31-35
34677445-1	2021	Sugar-based molecules such as heparins or natural heparan sulfate polysaccharides have been developed and widely studied for controlling heparanase (HPSE) enzymatic activity, a key player in extracellular matrix remodelling during cancer pathogenesis.	Heparitin Sulfate	50-65	heparanase	Homo sapiens	149-153
34180077-1	2021	Syndecan-4, a predicted target of the microRNA miR-140-3p, plays an important role in multiple steps of tumor progression and is the second most abundant heparan sulfate proteoglycan produced by breast carcinoma cell lines.	Heparitin Sulfate	154-169	syndecan 4	Homo sapiens	0-10
34549726-2	2021	IL-17-producing iNKT cells are commonly referred to as NKT17 cells, and they are unique among iNKT cells to express the heparan sulfate proteoglycan CD138 and the transcription factor RORgammat.	Heparitin Sulfate	120-135	interleukin 17A	Mus musculus	0-5
34549726-2	2021	IL-17-producing iNKT cells are commonly referred to as NKT17 cells, and they are unique among iNKT cells to express the heparan sulfate proteoglycan CD138 and the transcription factor RORgammat.	Heparitin Sulfate	120-135	syndecan 1	Mus musculus	149-154
34405855-0	2021	Decoding the consecutive lysosomal degradation of 3-O-sulfate containing heparan sulfate by Arylsulfatase G (ARSG).	Heparitin Sulfate	73-88	arylsulfatase G	Mus musculus	109-113
34552470-3	2021	Heparan sulfate proteoglycans are potent mediators of Abeta enrichment in the brain.	Heparitin Sulfate	0-15	amyloid beta precursor protein	Homo sapiens	54-59
34405855-8	2021	Our results confirm and extend the characterization of the substrate specificity of ARSG and help to determine the sequential order of the lysosomal catabolic breakdown of (3-O-)sulfated heparan sulfate.	Heparitin Sulfate	187-202	arylsulfatase G	Mus musculus	84-88
34552470-4	2021	We hypothesized the heparan sulfate proteoglycan glypican 4 (Gpc4) regulates Abeta internalization by NSCs.	Heparitin Sulfate	20-35	glypican 4	Homo sapiens	49-59
34552470-4	2021	We hypothesized the heparan sulfate proteoglycan glypican 4 (Gpc4) regulates Abeta internalization by NSCs.	Heparitin Sulfate	20-35	glypican 4	Homo sapiens	61-65
34552470-4	2021	We hypothesized the heparan sulfate proteoglycan glypican 4 (Gpc4) regulates Abeta internalization by NSCs.	Heparitin Sulfate	20-35	amyloid beta precursor protein	Homo sapiens	77-82
34107171-4	2021	Moreover, TF expression may also be induced by Heparanase, an endo-beta-D-glucuronidase, that generates heparan sulfate fragments, regulating inflammatory responses.	Heparitin Sulfate	104-119	heparanase	Homo sapiens	47-57
34364875-2	2021	Elevated serum CD138, a heparan sulfate-bearing proteoglycan, correlates with increased disease activity in SLE patients, but the contribution of CD138 to lupus disease is not known.	Heparitin Sulfate	24-39	syndecan 1	Homo sapiens	15-20
34542982-2	2021	Syndecan-1 (SDC-1) is a member of cell surface heparan sulfate proteoglycans and is mainly expressed in epithelial cells and plasma cells.	Heparitin Sulfate	47-62	syndecan 1	Homo sapiens	0-10
34542982-2	2021	Syndecan-1 (SDC-1) is a member of cell surface heparan sulfate proteoglycans and is mainly expressed in epithelial cells and plasma cells.	Heparitin Sulfate	47-62	syndecan 1	Homo sapiens	12-17
34107171-4	2021	Moreover, TF expression may also be induced by Heparanase, an endo-beta-D-glucuronidase, that generates heparan sulfate fragments, regulating inflammatory responses.	Heparitin Sulfate	104-119	glucuronidase beta	Homo sapiens	67-87
34525582-0	2021	Single-molecule force spectroscopy reveals structural differences of heparan sulfate chains during binding to vitronectin.	Heparitin Sulfate	69-84	vitronectin	Homo sapiens	110-121
34247932-1	2021	Sanfilippo syndrome type A (mucopolysaccharidosis type IIIA) is a rare autosomal recessive lysosomal disorder characterized by deficient heparan-N-sulfatase (HNS) activity, and subsequent accumulation of heparan sulfate, especially in the central nervous system.	Heparitin Sulfate	204-219	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-59
34433968-0	2021	APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans.	Heparitin Sulfate	43-58	TNF superfamily member 13	Homo sapiens	0-5
34433968-5	2021	Mechanistically, we demonstrate that APRIL confers atheroprotection by binding to heparan sulfate chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits the retention of low-density lipoproteins, accumulation of macrophages and formation of necrotic cores.	Heparitin Sulfate	82-97	TNF superfamily member 13	Homo sapiens	37-42
34433968-5	2021	Mechanistically, we demonstrate that APRIL confers atheroprotection by binding to heparan sulfate chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits the retention of low-density lipoproteins, accumulation of macrophages and formation of necrotic cores.	Heparitin Sulfate	82-97	heparan sulfate proteoglycan 2	Homo sapiens	108-138
34433968-5	2021	Mechanistically, we demonstrate that APRIL confers atheroprotection by binding to heparan sulfate chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits the retention of low-density lipoproteins, accumulation of macrophages and formation of necrotic cores.	Heparitin Sulfate	82-97	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	140-145
34461608-1	2021	Heparanase (HPSE), an endoglycosidase that cleaves heparan sulfate, regulates a variety of biological processes that promote tumor progression.	Heparitin Sulfate	51-66	heparanase	Homo sapiens	0-10
34461608-1	2021	Heparanase (HPSE), an endoglycosidase that cleaves heparan sulfate, regulates a variety of biological processes that promote tumor progression.	Heparitin Sulfate	51-66	heparanase	Homo sapiens	12-16
34106504-1	2021	Mucopolysaccharidosis type IIIB is a devastating neurological disease caused by a lack of the lysosomal enzyme,  alpha -N-acetylglucosaminidase (NAGLU), leading to a toxic accumulation of heparan sulfate.	Heparitin Sulfate	188-203	N-acetyl-alpha-glucosaminidase	Homo sapiens	113-143
34106504-1	2021	Mucopolysaccharidosis type IIIB is a devastating neurological disease caused by a lack of the lysosomal enzyme,  alpha -N-acetylglucosaminidase (NAGLU), leading to a toxic accumulation of heparan sulfate.	Heparitin Sulfate	188-203	N-acetyl-alpha-glucosaminidase	Homo sapiens	145-150
34106206-5	2021	We also used pentameric VISTA to identify Syndecan-2 and several heparan sulfate proteoglycan synthesis genes as novel regulators of VISTA interactions with monocytic cells, adding further evidence of bidirectional signaling.	Heparitin Sulfate	65-80	V-set immunoregulatory receptor	Homo sapiens	133-138
34653670-0	2021	Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.	Heparitin Sulfate	44-59	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	Mus musculus	8-16
34653670-0	2021	Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.	Heparitin Sulfate	44-59	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	Mus musculus	20-28
34343822-1	2021	Heparanase is highly implicated in tumor metastasis due to its capacity to cleave heparan sulfate and, consequently, remodel the extracellular matrix underlying epithelial and endothelial cells.	Heparitin Sulfate	82-97	heparanase	Homo sapiens	0-10
34343822-2	2021	In striking contrast, only little attention was given to its close homolog, heparanase 2 (Hpa2), possibly because it lacks heparan sulfate-degrading activity typical of heparanase.	Heparitin Sulfate	123-138	heparanase	Homo sapiens	169-179
34464450-0	2021	Application of a BMP2-binding heparan sulphate to promote periodontal regeneration.	Heparitin Sulfate	30-46	bone morphogenetic protein 2	Rattus norvegicus	17-21
34464450-3	2021	A heparan sulphate variant (HS3) with enhanced affinity for bone morphogenetic protein-2 (BMP2) that, when combined with collagen or ceramic biomaterials, enhances bone tissue regeneration in the axial and cranial skeleton in several animal models was reported previously.	Heparitin Sulfate	2-18	bone morphogenetic protein 2	Rattus norvegicus	60-88
34464450-3	2021	A heparan sulphate variant (HS3) with enhanced affinity for bone morphogenetic protein-2 (BMP2) that, when combined with collagen or ceramic biomaterials, enhances bone tissue regeneration in the axial and cranial skeleton in several animal models was reported previously.	Heparitin Sulfate	2-18	bone morphogenetic protein 2	Rattus norvegicus	90-94
34489650-1	2021	The heparan sulfate 6-O-endosulfatases, Sulfatase 1 (Sulf1), and Sulfatase 2 (Sulf2), are extracellular enzymes that regulate cellular signaling by removing 6-O-sulfate from the heparan sulfate chain.	Heparitin Sulfate	4-19	sulfatase 1	Mus musculus	40-51
34489650-1	2021	The heparan sulfate 6-O-endosulfatases, Sulfatase 1 (Sulf1), and Sulfatase 2 (Sulf2), are extracellular enzymes that regulate cellular signaling by removing 6-O-sulfate from the heparan sulfate chain.	Heparitin Sulfate	4-19	sulfatase 1	Mus musculus	53-58
34489650-1	2021	The heparan sulfate 6-O-endosulfatases, Sulfatase 1 (Sulf1), and Sulfatase 2 (Sulf2), are extracellular enzymes that regulate cellular signaling by removing 6-O-sulfate from the heparan sulfate chain.	Heparitin Sulfate	4-19	sulfatase 2	Mus musculus	65-76
34489650-1	2021	The heparan sulfate 6-O-endosulfatases, Sulfatase 1 (Sulf1), and Sulfatase 2 (Sulf2), are extracellular enzymes that regulate cellular signaling by removing 6-O-sulfate from the heparan sulfate chain.	Heparitin Sulfate	4-19	sulfatase 2	Mus musculus	78-83
34489650-1	2021	The heparan sulfate 6-O-endosulfatases, Sulfatase 1 (Sulf1), and Sulfatase 2 (Sulf2), are extracellular enzymes that regulate cellular signaling by removing 6-O-sulfate from the heparan sulfate chain.	Heparitin Sulfate	178-193	sulfatase 1	Mus musculus	40-51
34489650-1	2021	The heparan sulfate 6-O-endosulfatases, Sulfatase 1 (Sulf1), and Sulfatase 2 (Sulf2), are extracellular enzymes that regulate cellular signaling by removing 6-O-sulfate from the heparan sulfate chain.	Heparitin Sulfate	178-193	sulfatase 1	Mus musculus	53-58
34489650-1	2021	The heparan sulfate 6-O-endosulfatases, Sulfatase 1 (Sulf1), and Sulfatase 2 (Sulf2), are extracellular enzymes that regulate cellular signaling by removing 6-O-sulfate from the heparan sulfate chain.	Heparitin Sulfate	178-193	sulfatase 2	Mus musculus	65-76
34489650-1	2021	The heparan sulfate 6-O-endosulfatases, Sulfatase 1 (Sulf1), and Sulfatase 2 (Sulf2), are extracellular enzymes that regulate cellular signaling by removing 6-O-sulfate from the heparan sulfate chain.	Heparitin Sulfate	178-193	sulfatase 2	Mus musculus	78-83
34489931-0	2021	Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies.	Heparitin Sulfate	29-44	complement factor H	Homo sapiens	65-73
34489931-0	2021	Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies.	Heparitin Sulfate	29-44	complement factor H	Homo sapiens	78-86
34301723-8	2021	The released GPC4 contains the heparan sulfate side chain, suggesting that these release mechanisms provide the active form that promotes synapse maturation and function.	Heparitin Sulfate	31-46	glypican 4	Mus musculus	13-17
34324711-0	2021	Heparan sulfate proteoglycan molecules, syndecan and perlecan, have distinct roles in the maintenance of Drosophila germline stem cells.	Heparitin Sulfate	0-15	Syndecan	Drosophila melanogaster	40-48
34196550-2	2021	The attachment of heparan sulfate (HS) to S-pro is necessary for its binding to ACE2.	Heparitin Sulfate	18-33	angiotensin converting enzyme 2	Homo sapiens	80-84
34360653-2	2021	In MPS II, the first step of degradation of heparan sulfate (HS) and dermatan sulfate (DS) is blocked by a deficiency in the lysosomal enzyme iduronate 2-sulfatase (IDS), while, in MPS I, blockage of the second step is caused by a deficiency in iduronidase (IDUA).	Heparitin Sulfate	61-63	alpha-L-iduronidase	Homo sapiens	245-256
34131730-4	2021	Endoderm cell polarity is lost, and intercalation is impaired, in the absence of glypican 4 (gpc4), a heparan-sulfate proteoglycan that promotes Wnt/PCP signaling, suggesting that this signaling is required for endodermal cell polarity.	Heparitin Sulfate	102-117	glypican 4	Danio rerio	93-97
34360653-2	2021	In MPS II, the first step of degradation of heparan sulfate (HS) and dermatan sulfate (DS) is blocked by a deficiency in the lysosomal enzyme iduronate 2-sulfatase (IDS), while, in MPS I, blockage of the second step is caused by a deficiency in iduronidase (IDUA).	Heparitin Sulfate	44-59	iduronate 2-sulfatase	Homo sapiens	142-163
34360653-2	2021	In MPS II, the first step of degradation of heparan sulfate (HS) and dermatan sulfate (DS) is blocked by a deficiency in the lysosomal enzyme iduronate 2-sulfatase (IDS), while, in MPS I, blockage of the second step is caused by a deficiency in iduronidase (IDUA).	Heparitin Sulfate	44-59	iduronate 2-sulfatase	Homo sapiens	165-168
34360653-2	2021	In MPS II, the first step of degradation of heparan sulfate (HS) and dermatan sulfate (DS) is blocked by a deficiency in the lysosomal enzyme iduronate 2-sulfatase (IDS), while, in MPS I, blockage of the second step is caused by a deficiency in iduronidase (IDUA).	Heparitin Sulfate	44-59	alpha-L-iduronidase	Homo sapiens	245-256
34360653-2	2021	In MPS II, the first step of degradation of heparan sulfate (HS) and dermatan sulfate (DS) is blocked by a deficiency in the lysosomal enzyme iduronate 2-sulfatase (IDS), while, in MPS I, blockage of the second step is caused by a deficiency in iduronidase (IDUA).	Heparitin Sulfate	44-59	alpha-L-iduronidase	Homo sapiens	258-262
34360653-2	2021	In MPS II, the first step of degradation of heparan sulfate (HS) and dermatan sulfate (DS) is blocked by a deficiency in the lysosomal enzyme iduronate 2-sulfatase (IDS), while, in MPS I, blockage of the second step is caused by a deficiency in iduronidase (IDUA).	Heparitin Sulfate	61-63	iduronate 2-sulfatase	Homo sapiens	142-163
34360653-2	2021	In MPS II, the first step of degradation of heparan sulfate (HS) and dermatan sulfate (DS) is blocked by a deficiency in the lysosomal enzyme iduronate 2-sulfatase (IDS), while, in MPS I, blockage of the second step is caused by a deficiency in iduronidase (IDUA).	Heparitin Sulfate	61-63	iduronate 2-sulfatase	Homo sapiens	165-168
34356644-3	2021	The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the CD46 receptor or platelet factor 4 antibodies.	Heparitin Sulfate	122-137	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	55-60
34298676-2	2021	Chemokine function is dependent upon their binding to both cell-surface heparan sulphate (HS) and to their specific receptors; thus, the role of HS in CCR7-mediated lymph node metastasis was investigated by creating a non-HS binding chemokine CCL21 (mut-CCL21).	Heparitin Sulfate	145-147	chemokine (C-C motif) receptor 7	Mus musculus	151-155
34196550-2	2021	The attachment of heparan sulfate (HS) to S-pro is necessary for its binding to ACE2.	Heparitin Sulfate	35-37	angiotensin converting enzyme 2	Homo sapiens	80-84
34196550-4	2021	The free-energy landscape was characterized to elucidate the binding mechanism of S-pro to ACE2 with and without HS fragment DP4.	Heparitin Sulfate	113-115	transcription factor Dp family member 3	Homo sapiens	125-128
34209827-2	2021	The interaction between RSV, envelope glycoproteins G and F, and cell surface heparan sulfate proteoglycans (HSPG) is required for binding and entry into the host cells.	Heparitin Sulfate	78-93	syndecan 2	Homo sapiens	109-113
34087306-0	2021	Conformational changes of GDNF-derived peptide induced by heparin, heparan sulfate, and sulfated hyaluronic acid - Analysis by circular dichroism spectroscopy and molecular dynamics simulation.	Heparitin Sulfate	67-82	glial cell derived neurotrophic factor	Homo sapiens	26-30
34209670-4	2021	However, existing chemical inhibition methods for HS also interfere with chondroitin sulphate (CS), complicating data interpretation of HS function.	Heparitin Sulfate	50-52	citrate synthase	Homo sapiens	95-97
34220822-3	2021	Heparanase is an endoglycosidase that degrades heparan sulfate, resulting in remodeling of the extracellular matrix thereby facilitating the extravasation and migration of immune cells towards sites of inflammation.	Heparitin Sulfate	47-62	heparanase	Homo sapiens	0-10
34206469-1	2021	BACKGROUND: Syndecan-1 (CD138; SDC1) is a heparan sulfate proteoglycan that has been attributed a key role in cancer progression in ductal adenocarcinoma of the pancreas.	Heparitin Sulfate	42-57	syndecan 1	Homo sapiens	12-22
34206469-1	2021	BACKGROUND: Syndecan-1 (CD138; SDC1) is a heparan sulfate proteoglycan that has been attributed a key role in cancer progression in ductal adenocarcinoma of the pancreas.	Heparitin Sulfate	42-57	syndecan 1	Homo sapiens	24-29
34206469-1	2021	BACKGROUND: Syndecan-1 (CD138; SDC1) is a heparan sulfate proteoglycan that has been attributed a key role in cancer progression in ductal adenocarcinoma of the pancreas.	Heparitin Sulfate	42-57	syndecan 1	Homo sapiens	31-35
34165649-2	2021	Although structurally and mechanistically similar to the human lysosomal alpha-N-acetylglucosaminidase (hNAGLU) in GH89 which is involved in the degradation of heparan sulfate in the lysosome, the reported bacterial GH89 enzymes characterized so far have no or low activity toward alpha-N-acetylglucosamine-terminated heparosan oligosaccharides, the preferred substrates of hNAGLU.	Heparitin Sulfate	160-175	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	Homo sapiens	63-102
34165649-2	2021	Although structurally and mechanistically similar to the human lysosomal alpha-N-acetylglucosaminidase (hNAGLU) in GH89 which is involved in the degradation of heparan sulfate in the lysosome, the reported bacterial GH89 enzymes characterized so far have no or low activity toward alpha-N-acetylglucosamine-terminated heparosan oligosaccharides, the preferred substrates of hNAGLU.	Heparitin Sulfate	160-175	N-acetyl-alpha-glucosaminidase	Homo sapiens	104-110
34165649-2	2021	Although structurally and mechanistically similar to the human lysosomal alpha-N-acetylglucosaminidase (hNAGLU) in GH89 which is involved in the degradation of heparan sulfate in the lysosome, the reported bacterial GH89 enzymes characterized so far have no or low activity toward alpha-N-acetylglucosamine-terminated heparosan oligosaccharides, the preferred substrates of hNAGLU.	Heparitin Sulfate	160-175	N-acetyl-alpha-glucosaminidase	Homo sapiens	374-380
34165649-6	2021	This bacterial alpha-N-acetylglucosaminidase could be a useful catalyst for heparan sulfate analysis.	Heparitin Sulfate	76-91	N-acetyl-alpha-glucosaminidase	Homo sapiens	15-44
34235261-2	2021	Microarray binding experiments, using an extensive heparan sulfate (HS) oligosaccharide library, showed that the receptor binding domain (RBD) of the spike of SARS-CoV-2 can bind HS in a length- and sequence-dependent manner.	Heparitin Sulfate	51-66	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	150-155
34235261-2	2021	Microarray binding experiments, using an extensive heparan sulfate (HS) oligosaccharide library, showed that the receptor binding domain (RBD) of the spike of SARS-CoV-2 can bind HS in a length- and sequence-dependent manner.	Heparitin Sulfate	68-70	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	150-155
34220822-4	2021	Heparanase also releases heparan sulfate-bound cytokines and chemokines that further promote directed motility and recruitment of immune cells.	Heparitin Sulfate	25-40	heparanase	Homo sapiens	0-10
34069441-9	2021	Besides the polyanionic heparan sulfate chains, other parts of the syndecan ectodomain, such as the cell-binding domain, also contribute to the interaction with SARS-CoV-2.	Heparitin Sulfate	24-39	syndecan 1	Homo sapiens	67-75
34222264-5	2021	Recent reports have demonstrated that chondroitin sulfate and heparan sulfate, both of which are glycosaminoglycans, work as physiological ligands on their shared receptor, protein tyrosine phosphatase sigma (PTPsigma).	Heparitin Sulfate	62-77	protein tyrosine phosphatase receptor type S	Homo sapiens	209-217
34179075-0	2021	Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer.	Heparitin Sulfate	0-15	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	28-33
34179075-2	2021	Cellular heparan sulfate (HS) has been found to bind SARS-CoV-2 spike protein (SV2-S) and co-operate with cell surface receptor angiotensin-converting enzyme 2 (ACE2) to mediate SARS-CoV-2 infection of host cells.	Heparitin Sulfate	9-24	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	64-69
34179075-2	2021	Cellular heparan sulfate (HS) has been found to bind SARS-CoV-2 spike protein (SV2-S) and co-operate with cell surface receptor angiotensin-converting enzyme 2 (ACE2) to mediate SARS-CoV-2 infection of host cells.	Heparitin Sulfate	9-24	angiotensin converting enzyme 2	Homo sapiens	128-159
34179075-2	2021	Cellular heparan sulfate (HS) has been found to bind SARS-CoV-2 spike protein (SV2-S) and co-operate with cell surface receptor angiotensin-converting enzyme 2 (ACE2) to mediate SARS-CoV-2 infection of host cells.	Heparitin Sulfate	9-24	angiotensin converting enzyme 2	Homo sapiens	161-165
34179075-5	2021	The binding of heparin/HS to SV2-S is mainly determined by its overall sulfation with potential, minor contribution of specific SV2-S binding motifs.	Heparitin Sulfate	23-25	synaptic vesicle glycoprotein 2A	Homo sapiens	29-32
34179075-8	2021	Our findings support blocking HS-SV2-S interaction may provide one addition to achieve effective prevention and/treatment of COVID-19.	Heparitin Sulfate	30-32	synaptic vesicle glycoprotein 2A	Homo sapiens	33-36
34073798-9	2021	Another HSPG, glypican 4, binds to presynaptic PTPsigma and postsynaptic LRRTM4 in an HS-dependent manner.	Heparitin Sulfate	86-88	CD44 molecule (Indian blood group)	Homo sapiens	8-12
34073798-9	2021	Another HSPG, glypican 4, binds to presynaptic PTPsigma and postsynaptic LRRTM4 in an HS-dependent manner.	Heparitin Sulfate	86-88	glypican 4	Homo sapiens	14-24
34073798-9	2021	Another HSPG, glypican 4, binds to presynaptic PTPsigma and postsynaptic LRRTM4 in an HS-dependent manner.	Heparitin Sulfate	86-88	leucine rich repeat transmembrane neuronal 4	Homo sapiens	73-79
34200372-11	2021	The glycosaminoglycans heparan sulphate and dermatan sulphate, but not chondroitin sulphate, also inhibited the binding of spike protein, indicating that it might bind to one or both of these glycosaminoglycans on the surface of target cells.	Heparitin Sulfate	23-39	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	123-128
34079082-2	2021	Glypican-5 (GPC5) is a member of heparan sulfate proteoglycans, and its biological importance in initiation and progression of lung cancer remains controversial.	Heparitin Sulfate	33-48	glypican 5	Homo sapiens	0-10
34079082-2	2021	Glypican-5 (GPC5) is a member of heparan sulfate proteoglycans, and its biological importance in initiation and progression of lung cancer remains controversial.	Heparitin Sulfate	33-48	glypican 5	Homo sapiens	12-16
34156395-1	2021	Heparanase (Hpse) is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate side chains.	Heparitin Sulfate	70-85	heparanase	Homo sapiens	0-10
34156395-1	2021	Heparanase (Hpse) is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate side chains.	Heparitin Sulfate	70-85	heparanase	Homo sapiens	12-16
34156395-1	2021	Heparanase (Hpse) is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate side chains.	Heparitin Sulfate	70-85	glucuronidase beta	Homo sapiens	29-49
34191695-2	2021	The cell surface heparan sulfate proteoglycan Syndecan-1 is dysregulated both in tumor cells and cells of the breast tumor stroma, indicating a potential role in the pathogenesis of this most frequent malignancy in women.	Heparitin Sulfate	17-32	syndecan 1	Homo sapiens	46-56
34163672-2	2021	Here, we describe for the first time a state-of-the-art design for a heparan sulfate (HS) oligosaccharide-based nanovehicle to target EGFR-overexpressed cancer cells in cellular heterogeneity.	Heparitin Sulfate	69-84	epidermal growth factor receptor	Homo sapiens	134-138
35183674-8	2022	Additionally, via gene expression analysis, downregulation of SDC1/4 decreased the biosynthesis of heparan sulfate modification enzymes and reduced expression of Wnt signalling molecules.	Heparitin Sulfate	99-114	syndecan 1	Homo sapiens	62-68
35585797-0	2022	Design and Synthesis of 6-O-Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid beta Aggregation.	Heparitin Sulfate	43-58	amyloid beta precursor protein	Homo sapiens	87-99
35578904-2	2022	Here, on the basis of the synthetic methods of zeolitic imidazolate framework-90 (ZIF-90), we prepared bimetal organic material (BMOM) microreactors that successfully encapsulated Pasteurella multocida heparosan synthase 2 (PmHS2), a critical glycosyltransferase in the enzymatic synthesis of heparin and heparan sulfate.	Heparitin Sulfate	305-320	glycosyltransferase family 9 protein	Pasteurella multocida	243-262
35452701-0	2022	Heparan sulfate proteoglycans-mediated targeted delivery of TGF-beta1-binding peptide to liver for improved anti-liver fibrotic activity in vitro and in vivo.	Heparitin Sulfate	0-15	transforming growth factor beta 1	Homo sapiens	60-69
35628603-0	2022	The Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 Promotes Ovarian Cancer Pathogenesis.	Heparitin Sulfate	17-32	syndecan 3	Homo sapiens	46-56
35137078-0	2022	A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation.	Heparitin Sulfate	42-57	N-deacetylase and N-sulfotransferase 1	Homo sapiens	78-83
35137078-0	2022	A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation.	Heparitin Sulfate	92-107	N-deacetylase and N-sulfotransferase 1	Homo sapiens	78-83
35137078-1	2022	NDST1 (glucosaminyl N-deacetylase/N-sulfotransferase) is a key enzyme in heparan sulfate (HS) biosynthesis where it is responsible for HS N-deacetylation and N-sulfation.	Heparitin Sulfate	73-88	N-deacetylase and N-sulfotransferase 1	Homo sapiens	0-5
35137078-1	2022	NDST1 (glucosaminyl N-deacetylase/N-sulfotransferase) is a key enzyme in heparan sulfate (HS) biosynthesis where it is responsible for HS N-deacetylation and N-sulfation.	Heparitin Sulfate	90-92	N-deacetylase and N-sulfotransferase 1	Homo sapiens	0-5
35587107-0	2022	The heparan sulphate proteoglycan Syndecan-1 (CD138) regulates tumour progression in a 3D model of ductal carcinoma in situ of the breast.	Heparitin Sulfate	4-20	syndecan 1	Homo sapiens	34-44
35587107-0	2022	The heparan sulphate proteoglycan Syndecan-1 (CD138) regulates tumour progression in a 3D model of ductal carcinoma in situ of the breast.	Heparitin Sulfate	4-20	syndecan 1	Homo sapiens	46-51
35587107-2	2022	Dysregulation of the transmembrane heparan sulphate proteoglycan Syndecan-1 (Sdc-1) plays a role in tumour progression of invasive breast cancer (IBC).	Heparitin Sulfate	35-51	syndecan 1	Homo sapiens	65-75
35587107-2	2022	Dysregulation of the transmembrane heparan sulphate proteoglycan Syndecan-1 (Sdc-1) plays a role in tumour progression of invasive breast cancer (IBC).	Heparitin Sulfate	35-51	syndecan 1	Homo sapiens	77-82
35562558-7	2022	For HSV-1, infection is mediated via the HSV-1-specific entry receptor 3-O sulfated heparan sulfate (3-OS HS) in a pH-depended manner, and CGRP down-regulates 3-OS HS surface expression, as well as abrogates pH dependency.	Heparitin Sulfate	84-99	calcitonin related polypeptide alpha	Homo sapiens	139-143
35631109-8	2022	Antisense to N-deacetylase N-sulfotransferase1 (ASONdst1) that modifies heparan sulfate, was less effective with immediate pre-treatment, but reduced scarring and C4d staining with donor pre-treatment for 7 days before transplantation.	Heparitin Sulfate	72-87	N-deacetylase and N-sulfotransferase 1	Homo sapiens	13-46
35584326-1	2022	Syndecan-1 (SDC1, CD138) is one of the heparan sulfate proteoglycans and is essential for maintaining normal cell morphology, interacting with extracellular and intracellular protein repertoire as well as mediating signaling transduction upon environmental stimuli.	Heparitin Sulfate	39-54	syndecan 1	Homo sapiens	0-10
35584326-1	2022	Syndecan-1 (SDC1, CD138) is one of the heparan sulfate proteoglycans and is essential for maintaining normal cell morphology, interacting with extracellular and intracellular protein repertoire as well as mediating signaling transduction upon environmental stimuli.	Heparitin Sulfate	39-54	syndecan 1	Homo sapiens	12-16
35584326-1	2022	Syndecan-1 (SDC1, CD138) is one of the heparan sulfate proteoglycans and is essential for maintaining normal cell morphology, interacting with extracellular and intracellular protein repertoire as well as mediating signaling transduction upon environmental stimuli.	Heparitin Sulfate	39-54	syndecan 1	Homo sapiens	18-23
35354934-0	2022	Author Correction: Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate.	Heparitin Sulfate	89-104	lysine demethylase 2B	Homo sapiens	47-52
35420441-9	2022	Finally, we constructed a model for EV71 entry in which both heparan sulfate and SCARB2 are regulated by SLC35B2 and act cooperatively to support viral binding, internalization, and uncoating.	Heparitin Sulfate	61-76	solute carrier family 35 member B2	Homo sapiens	105-112
35420441-11	2022	Furthermore, we found that a novel host factor, SLC35B2, played a dual role in regulating the overall sulfation comprising heparan sulfate sulfation and protein tyrosine sulfation, which are critical for EV71 entry.	Heparitin Sulfate	123-138	solute carrier family 35 member B2	Homo sapiens	48-55
35525272-2	2022	This begins with tau binding to cell surface heparan sulfate proteoglycans, which triggers macropinocytosis.	Heparitin Sulfate	45-60	microtubule associated protein tau	Homo sapiens	17-20
35388870-0	2022	Synthesis of novel S- and O-disaccharide analogs of heparan sulfate for heparanase inhibition.	Heparitin Sulfate	52-67	heparanase	Homo sapiens	72-82
35307462-2	2022	Notably, the nonnegligible role of endogenous heparan sulfate (HS) in the release, uptake and misfolding of Abeta sheds light on the discovery of HS as an effective drug for AD.	Heparitin Sulfate	46-61	amyloid beta precursor protein	Homo sapiens	108-113
35331918-1	2022	The heparan sulphate proteoglycan Syndecan-4 belongs to a 4-member family of transmembrane receptors.	Heparitin Sulfate	4-20	syndecan 4	Mus musculus	34-44
35552402-11	2022	Both RRMECs and retinas of diabetic rats exhibited glucose-induced alterations in the disaccharide compositions and sulfation of HS and CS, with the changes in sulfation including N,6-O-sulfation on HS and 4-O-sulfation on CS.	Heparitin Sulfate	129-131	citrate synthase	Rattus norvegicus	223-225
35563446-2	2022	Degradation of heparan sulfate by human and mouse heparanase was inhibited by sulfated hyaluronan.	Heparitin Sulfate	15-30	heparanase	Mus musculus	50-60
35247648-5	2022	There are four cysteine residues forming two disulfide linkage and 14 basic amino acid residues which result in a very basic property for the binding of IL-8 to heparan sulfate-proteoglycan.	Heparitin Sulfate	161-176	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
35131262-4	2022	In this study, we investigated the abnormalities of the commissural fibers that connect the left and right cerebral hemispheres in mice lacking heparan sulfate 6-O endosulfatases, Sulf1 and Sulf2 (Sulf1/2), which are extracellular enzymes that remove 6-O sulfate from heparan sulfate and thereby modulate the function of axon guidance factors.	Heparitin Sulfate	144-159	sulfatase 2	Mus musculus	197-204
35131262-4	2022	In this study, we investigated the abnormalities of the commissural fibers that connect the left and right cerebral hemispheres in mice lacking heparan sulfate 6-O endosulfatases, Sulf1 and Sulf2 (Sulf1/2), which are extracellular enzymes that remove 6-O sulfate from heparan sulfate and thereby modulate the function of axon guidance factors.	Heparitin Sulfate	268-283	sulfatase 1	Mus musculus	180-185
35131262-4	2022	In this study, we investigated the abnormalities of the commissural fibers that connect the left and right cerebral hemispheres in mice lacking heparan sulfate 6-O endosulfatases, Sulf1 and Sulf2 (Sulf1/2), which are extracellular enzymes that remove 6-O sulfate from heparan sulfate and thereby modulate the function of axon guidance factors.	Heparitin Sulfate	268-283	sulfatase 2	Mus musculus	190-195
35131262-4	2022	In this study, we investigated the abnormalities of the commissural fibers that connect the left and right cerebral hemispheres in mice lacking heparan sulfate 6-O endosulfatases, Sulf1 and Sulf2 (Sulf1/2), which are extracellular enzymes that remove 6-O sulfate from heparan sulfate and thereby modulate the function of axon guidance factors.	Heparitin Sulfate	268-283	sulfatase 2	Mus musculus	197-204
35477501-1	2022	BACKGROUND: Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, is a biomarker of hepatocellular carcinoma (HCC) progression.	Heparitin Sulfate	48-63	glypican 3	Homo sapiens	12-22
35477501-1	2022	BACKGROUND: Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, is a biomarker of hepatocellular carcinoma (HCC) progression.	Heparitin Sulfate	48-63	glypican 3	Homo sapiens	24-28
35490075-3	2022	Building on previous research, a component of this process has been identified to be glypican-1 (GPC1), a GPI-anchored heparan sulfate proteoglycan located on cell surfaces.	Heparitin Sulfate	119-134	glypican 1	Homo sapiens	85-95
35490075-3	2022	Building on previous research, a component of this process has been identified to be glypican-1 (GPC1), a GPI-anchored heparan sulfate proteoglycan located on cell surfaces.	Heparitin Sulfate	119-134	glypican 1	Homo sapiens	97-101
35319225-3	2022	Many viruses use heparan sulfate proteoglycans as coreceptors for viral entry, and heparanase (HPSE) is a known regulator of both viral entry and inflammatory cytokines.	Heparitin Sulfate	17-32	heparanase	Homo sapiens	83-93
35563015-4	2022	To resolve this issue we exploited heparanase-1 (HPSE-1), the only endoglycosidase in mammals that digests heparan sulfate (HS), a major constituent of BM.	Heparitin Sulfate	107-122	heparanase	Homo sapiens	35-47
35563015-4	2022	To resolve this issue we exploited heparanase-1 (HPSE-1), the only endoglycosidase in mammals that digests heparan sulfate (HS), a major constituent of BM.	Heparitin Sulfate	107-122	heparanase	Homo sapiens	49-55
35548440-3	2022	Syndecan-1 (SDC-1) is a heparan sulfate proteoglycan that is implicated in extracellular matrix (ECM) interaction and assembly, regulation of SMCs phenotype, and various aspects of inflammation in the vascular wall.	Heparitin Sulfate	24-39	syndecan 1	Homo sapiens	0-10
35548440-3	2022	Syndecan-1 (SDC-1) is a heparan sulfate proteoglycan that is implicated in extracellular matrix (ECM) interaction and assembly, regulation of SMCs phenotype, and various aspects of inflammation in the vascular wall.	Heparitin Sulfate	24-39	syndecan 1	Mus musculus	12-17
35440680-0	2022	Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection.	Heparitin Sulfate	25-40	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	41-46
35440680-2	2022	In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan (GAG) attached to certain membrane proteins on the cell surface.	Heparitin Sulfate	87-102	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	49-54
35440680-2	2022	In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan (GAG) attached to certain membrane proteins on the cell surface.	Heparitin Sulfate	87-102	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	56-57
35440680-4	2022	Here, we show that Mitoxantrone, an FDA-approved topoisomerase inhibitor, targets a heparan sulfate-spike complex to compromise the fusogenic function of spike in viral entry.	Heparitin Sulfate	84-99	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	100-105
35440680-4	2022	Here, we show that Mitoxantrone, an FDA-approved topoisomerase inhibitor, targets a heparan sulfate-spike complex to compromise the fusogenic function of spike in viral entry.	Heparitin Sulfate	84-99	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	154-159
35319225-3	2022	Many viruses use heparan sulfate proteoglycans as coreceptors for viral entry, and heparanase (HPSE) is a known regulator of both viral entry and inflammatory cytokines.	Heparitin Sulfate	17-32	heparanase	Homo sapiens	95-99
35412619-1	2022	OBJECTIVES: To study the mechanism by which the readthrough mutation in TNFRSF11B encoding OPG-XL, previously shown to affect binding between OPG and heparan sulphate (HS) causes the characteristic bidirectional phenotype of subchondral bone turnover accompanied by cartilage mineralization in CCAL1 chondrocalcinosis patients.	Heparitin Sulfate	150-166	TNF receptor superfamily member 11b	Homo sapiens	72-81
35412619-1	2022	OBJECTIVES: To study the mechanism by which the readthrough mutation in TNFRSF11B encoding OPG-XL, previously shown to affect binding between OPG and heparan sulphate (HS) causes the characteristic bidirectional phenotype of subchondral bone turnover accompanied by cartilage mineralization in CCAL1 chondrocalcinosis patients.	Heparitin Sulfate	150-166	TNF receptor superfamily member 11b	Homo sapiens	142-145
35412619-1	2022	OBJECTIVES: To study the mechanism by which the readthrough mutation in TNFRSF11B encoding OPG-XL, previously shown to affect binding between OPG and heparan sulphate (HS) causes the characteristic bidirectional phenotype of subchondral bone turnover accompanied by cartilage mineralization in CCAL1 chondrocalcinosis patients.	Heparitin Sulfate	150-166	CCAL1	Homo sapiens	294-299
35412619-1	2022	OBJECTIVES: To study the mechanism by which the readthrough mutation in TNFRSF11B encoding OPG-XL, previously shown to affect binding between OPG and heparan sulphate (HS) causes the characteristic bidirectional phenotype of subchondral bone turnover accompanied by cartilage mineralization in CCAL1 chondrocalcinosis patients.	Heparitin Sulfate	168-170	TNF receptor superfamily member 11b	Homo sapiens	72-81
35412619-1	2022	OBJECTIVES: To study the mechanism by which the readthrough mutation in TNFRSF11B encoding OPG-XL, previously shown to affect binding between OPG and heparan sulphate (HS) causes the characteristic bidirectional phenotype of subchondral bone turnover accompanied by cartilage mineralization in CCAL1 chondrocalcinosis patients.	Heparitin Sulfate	168-170	TNF receptor superfamily member 11b	Homo sapiens	142-145
35412619-1	2022	OBJECTIVES: To study the mechanism by which the readthrough mutation in TNFRSF11B encoding OPG-XL, previously shown to affect binding between OPG and heparan sulphate (HS) causes the characteristic bidirectional phenotype of subchondral bone turnover accompanied by cartilage mineralization in CCAL1 chondrocalcinosis patients.	Heparitin Sulfate	168-170	CCAL1	Homo sapiens	294-299
35248846-4	2022	Further, FN1 possesses multiple binding domains including collagen, integrin, and heparin that can interact with heparan sulfate proteoglycans at the surface of chondrocyte leading to promote cell signaling and differentiation.	Heparitin Sulfate	113-128	fibronectin 1	Homo sapiens	9-12
35121108-1	2022	Mucopolysaccharidosis type IIIA is an autosomal recessive disorder caused by mutations in SGSH involved in the degradation of heparan sulfate.	Heparitin Sulfate	126-141	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	90-94
35348113-5	2022	We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity.	Heparitin Sulfate	164-179	glypican 1	Homo sapiens	56-60
35040015-0	2022	Heparan Sulfate Proteoglycans (HSPGs) Serve as the Mediator Between Monomeric Tau and Its Subsequent Intracellular ERK1/2 Pathway Activation.	Heparitin Sulfate	0-15	microtubule associated protein tau	Homo sapiens	78-81
35040015-0	2022	Heparan Sulfate Proteoglycans (HSPGs) Serve as the Mediator Between Monomeric Tau and Its Subsequent Intracellular ERK1/2 Pathway Activation.	Heparitin Sulfate	0-15	mitogen-activated protein kinase 3	Homo sapiens	115-121
35348113-5	2022	We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity.	Heparitin Sulfate	164-179	fibroblast growth factor 2	Homo sapiens	71-75
35348113-5	2022	We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity.	Heparitin Sulfate	164-179	glypican 1	Homo sapiens	190-194
35348113-5	2022	We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity.	Heparitin Sulfate	164-179	fibroblast growth factor 2	Homo sapiens	204-208
35433697-9	2022	Membrane-inserted FGF2 oligomers are recognized as translocation intermediates that are resolved at the outer plasma membrane leaflet by glypican-1, a heparan sulfate proteoglycan that captures and disassembles FGF2 oligomers on cell surfaces.	Heparitin Sulfate	151-166	fibroblast growth factor 2	Homo sapiens	18-22
35433697-9	2022	Membrane-inserted FGF2 oligomers are recognized as translocation intermediates that are resolved at the outer plasma membrane leaflet by glypican-1, a heparan sulfate proteoglycan that captures and disassembles FGF2 oligomers on cell surfaces.	Heparitin Sulfate	151-166	glypican 1	Homo sapiens	137-147
35433697-9	2022	Membrane-inserted FGF2 oligomers are recognized as translocation intermediates that are resolved at the outer plasma membrane leaflet by glypican-1, a heparan sulfate proteoglycan that captures and disassembles FGF2 oligomers on cell surfaces.	Heparitin Sulfate	151-166	fibroblast growth factor 2	Homo sapiens	211-215
35168097-1	2022	Keipert syndrome(KS, OMIM:301026) is a rare X-linked recessive inherited disorder characterized by distinctive facial appearance and digital abnormalities, and the disease is caused by hemizygous mutations in the GPC4 gene encoding the heparan sulfate proteoglycan glypican 4.	Heparitin Sulfate	236-251	glypican 4	Homo sapiens	213-217
35168097-1	2022	Keipert syndrome(KS, OMIM:301026) is a rare X-linked recessive inherited disorder characterized by distinctive facial appearance and digital abnormalities, and the disease is caused by hemizygous mutations in the GPC4 gene encoding the heparan sulfate proteoglycan glypican 4.	Heparitin Sulfate	236-251	glypican 4	Homo sapiens	265-275
35354833-0	2022	Genetic alteration of heparan sulfate in CD11c + immune cells inhibits inflammation and facilitates pathogen clearance during influenza A virus infection.	Heparitin Sulfate	22-37	integrin subunit alpha X	Homo sapiens	41-46
35354833-2	2022	We demonstrate that genetic alteration of the glycan heparan sulfate (HS) in CD11c + cells via Ndst1f/f CD11cCre + mutation, which inhibits HS sulfation in a major antigen presenting cell population, reduces lung inflammation by A/Puerto Rico/8/1934(H1N1) influenza in mice.	Heparitin Sulfate	53-68	integrin subunit alpha X	Homo sapiens	77-82
35354833-2	2022	We demonstrate that genetic alteration of the glycan heparan sulfate (HS) in CD11c + cells via Ndst1f/f CD11cCre + mutation, which inhibits HS sulfation in a major antigen presenting cell population, reduces lung inflammation by A/Puerto Rico/8/1934(H1N1) influenza in mice.	Heparitin Sulfate	70-72	integrin subunit alpha X	Homo sapiens	77-82
35346008-10	2022	Several heterogeneous conditions that share the occurrence of insulin resistance, such as aging, obesity, acromegaly, lipodystrophy, cystic fibrosis, insulin receptor dysfunction, and Alstrom syndrome, also share both clinical and structural manifestations of kidney disease, including glomerulomegaly and other features of DKD, focal segmental glomerulosclerosis, and C3 glomerulopathy, which might be ascribed to reduction in the synthesis of factor H binding sites (such as heparan sulfate) that leads to uncontrolled complement activation.	Heparitin Sulfate	477-492	insulin	Homo sapiens	62-69
35346008-10	2022	Several heterogeneous conditions that share the occurrence of insulin resistance, such as aging, obesity, acromegaly, lipodystrophy, cystic fibrosis, insulin receptor dysfunction, and Alstrom syndrome, also share both clinical and structural manifestations of kidney disease, including glomerulomegaly and other features of DKD, focal segmental glomerulosclerosis, and C3 glomerulopathy, which might be ascribed to reduction in the synthesis of factor H binding sites (such as heparan sulfate) that leads to uncontrolled complement activation.	Heparitin Sulfate	477-492	insulin receptor	Homo sapiens	150-166
34986000-0	2022	Attenuation of Getah virus by a single amino acid substitution at residue 253 of the E2 protein that might be part of a new heparan sulfate binding site on alphaviruses.	Heparitin Sulfate	124-139	ubiquitin conjugating enzyme E2 B	Homo sapiens	85-95
35346305-2	2022	Through its heparan sulfate chain, CD44 presents growth factors to their receptors.	Heparitin Sulfate	12-27	CD44 antigen	Mus musculus	35-39
35284671-1	2022	Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a rare X-linked recessive disease caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS), which activates intracellular accumulation of nonmetabolized glycosaminoglycans such as heparan sulfate and dermatan sulfate.	Heparitin Sulfate	272-287	iduronate 2-sulfatase	Mus musculus	155-176
35020256-3	2022	We propose based on a chemical rational that the elevated occurrence of positively charged amino acids in certain domains of the spike protein (Delta: +4; Omicron: +5 vs. wild type) increases binding to cellular polyanionic receptors, such as heparan sulfate due to multivalent charge-charge interactions.	Heparitin Sulfate	243-258	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	129-134
35285802-8	2022	Targeting heparan sulfate proteoglycans with the specific heparan sulfate antagonist Surfen reduces ERK1/2 signaling and decreases tumorigenicity of Ewing sarcoma cells in vitro and in vivo.	Heparitin Sulfate	10-25	mitogen-activated protein kinase 3	Homo sapiens	100-106
35285802-8	2022	Targeting heparan sulfate proteoglycans with the specific heparan sulfate antagonist Surfen reduces ERK1/2 signaling and decreases tumorigenicity of Ewing sarcoma cells in vitro and in vivo.	Heparitin Sulfate	58-73	mitogen-activated protein kinase 3	Homo sapiens	100-106
35269476-7	2022	In particular, the importance of considering secondary co-receptors for Spike, such as heparan sulfate proteoglycans is discussed.	Heparitin Sulfate	87-102	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	72-77
35236856-0	2022	Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate.	Heparitin Sulfate	75-91	fibroblast growth factor 2	Homo sapiens	45-49
35312866-2	2022	In this study, we disrupted the Golgi structure by knocking out GRASP55 and GRASP65 and determined its effect on the synthesis, sulfation, and secretion of HS and CS.	Heparitin Sulfate	156-158	golgi reassembly stacking protein 2	Homo sapiens	64-71
35312866-2	2022	In this study, we disrupted the Golgi structure by knocking out GRASP55 and GRASP65 and determined its effect on the synthesis, sulfation, and secretion of HS and CS.	Heparitin Sulfate	156-158	golgi reassembly stacking protein 1	Homo sapiens	76-83
35312866-3	2022	We found that GRASP depletion increased HS synthesis while decreasing CS synthesis in cells, altered HS and CS sulfation, and reduced both HS and CS secretion.	Heparitin Sulfate	40-42	trafficking regulator and scaffold protein tamalin	Homo sapiens	14-19
35312866-3	2022	We found that GRASP depletion increased HS synthesis while decreasing CS synthesis in cells, altered HS and CS sulfation, and reduced both HS and CS secretion.	Heparitin Sulfate	101-103	trafficking regulator and scaffold protein tamalin	Homo sapiens	14-19
35312866-3	2022	We found that GRASP depletion increased HS synthesis while decreasing CS synthesis in cells, altered HS and CS sulfation, and reduced both HS and CS secretion.	Heparitin Sulfate	139-141	trafficking regulator and scaffold protein tamalin	Homo sapiens	14-19
35312866-5	2022	In addition, we found that GRASP depletion decreased HS sulfation via the reduction of PAPSS2, a bifunctional enzyme in HS sulfation.	Heparitin Sulfate	53-55	trafficking regulator and scaffold protein tamalin	Homo sapiens	27-32
35312866-5	2022	In addition, we found that GRASP depletion decreased HS sulfation via the reduction of PAPSS2, a bifunctional enzyme in HS sulfation.	Heparitin Sulfate	53-55	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	87-93
35312866-5	2022	In addition, we found that GRASP depletion decreased HS sulfation via the reduction of PAPSS2, a bifunctional enzyme in HS sulfation.	Heparitin Sulfate	120-122	trafficking regulator and scaffold protein tamalin	Homo sapiens	27-32
35312866-5	2022	In addition, we found that GRASP depletion decreased HS sulfation via the reduction of PAPSS2, a bifunctional enzyme in HS sulfation.	Heparitin Sulfate	120-122	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	87-93
35142364-0	2022	Hedgehog pathway modulation by glypican 3-conjugated heparan sulfate.	Heparitin Sulfate	53-68	glypican 3	Homo sapiens	31-41
35142364-8	2022	Our results demonstrate a novel function of GPC3-associated heparan sulfate, and provide a framework for the functional dissection of glycosaminoglycans by in vivo biochemical complementation.	Heparitin Sulfate	60-75	glypican 3	Homo sapiens	44-48
35284671-1	2022	Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a rare X-linked recessive disease caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS), which activates intracellular accumulation of nonmetabolized glycosaminoglycans such as heparan sulfate and dermatan sulfate.	Heparitin Sulfate	272-287	iduronate 2-sulfatase	Mus musculus	178-181
35143487-0	2022	Circadian control of heparan sulfate levels times phagocytosis of amyloid beta aggregates.	Heparitin Sulfate	21-36	amyloid beta precursor protein	Homo sapiens	66-78
35229724-6	2022	The GPIHBP1-bound LPL was trapped on the abluminal surface of ECs by electrostatic interactions between the large basic patch on the surface of LPL and negatively charged heparan sulfate proteoglycans (HSPGs) on the surface of ECs.	Heparitin Sulfate	171-186	GPI-anchored HDL-binding protein 1	Mus musculus	4-11
35229724-6	2022	The GPIHBP1-bound LPL was trapped on the abluminal surface of ECs by electrostatic interactions between the large basic patch on the surface of LPL and negatively charged heparan sulfate proteoglycans (HSPGs) on the surface of ECs.	Heparitin Sulfate	171-186	lipoprotein lipase	Mus musculus	18-21
35103870-1	2022	In this study, the effect of heterozygous germline mutations in the heparan sulfate (HS) glycosaminoglycan chain co-polymerases EXT1 and EXT2 on glomerular barrier function and the endothelial glycocalyx in humans is investigated.	Heparitin Sulfate	68-83	exostosin glycosyltransferase 1	Homo sapiens	128-132
35103870-1	2022	In this study, the effect of heterozygous germline mutations in the heparan sulfate (HS) glycosaminoglycan chain co-polymerases EXT1 and EXT2 on glomerular barrier function and the endothelial glycocalyx in humans is investigated.	Heparitin Sulfate	68-83	exostosin glycosyltransferase 2	Homo sapiens	137-141
34981584-1	2022	Pixatimod (PG545), a heparan sulfate (HS) mimetic and anticancer agent currently in clinical trials, is a potent inhibitor of heparanase.	Heparitin Sulfate	21-36	heparanase	Homo sapiens	126-136
34981584-1	2022	Pixatimod (PG545), a heparan sulfate (HS) mimetic and anticancer agent currently in clinical trials, is a potent inhibitor of heparanase.	Heparitin Sulfate	38-40	heparanase	Homo sapiens	126-136
34981584-2	2022	Heparanase is an endo -beta-glucuronidase that degrades HS in the extracellular matrix and basement membranes and is implicated in numerous pathological processes such as cancer and viral infections, including SARS-CoV-2.	Heparitin Sulfate	56-58	heparanase	Homo sapiens	0-10
35169535-1	2022	The heparin polysaccharide nanoparticles block the interaction between heparan sulfate/S protein and inhibit the infection of both wild-type SARS-CoV-2 pseudovirus and the mutated strains through pulmonary delivery.Image 1.	Heparitin Sulfate	71-86	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	87-88
35323233-5	2022	The rescue of YAP signaling with the heparan sulfate proteoglycan agrin resulted in a return of the nuclear YAP signal.	Heparitin Sulfate	37-52	yes-associated protein 1	Mus musculus	14-17
35323233-5	2022	The rescue of YAP signaling with the heparan sulfate proteoglycan agrin resulted in a return of the nuclear YAP signal.	Heparitin Sulfate	37-52	agrin	Mus musculus	66-71
35323233-5	2022	The rescue of YAP signaling with the heparan sulfate proteoglycan agrin resulted in a return of the nuclear YAP signal.	Heparitin Sulfate	37-52	yes-associated protein 1	Mus musculus	108-111
35060381-0	2022	Structural Insights into the Cofactor Role of Heparin/Heparan Sulfate in Binding between the SARS-CoV-2 Spike Protein and Host Angiotensin-Converting Enzyme II.	Heparitin Sulfate	54-69	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	104-109
35060381-1	2022	The viral entry process of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires heparin and heparan sulfates from the cell surface, functioning as a cofactor for human angiotensin-converting enzyme 2 (ACE2) for recognizing the receptor-binding domain (RBD) of the spike (S) protein on the surface of the virion.	Heparitin Sulfate	119-135	angiotensin converting enzyme 2	Homo sapiens	195-226
35060381-1	2022	The viral entry process of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires heparin and heparan sulfates from the cell surface, functioning as a cofactor for human angiotensin-converting enzyme 2 (ACE2) for recognizing the receptor-binding domain (RBD) of the spike (S) protein on the surface of the virion.	Heparitin Sulfate	119-135	angiotensin converting enzyme 2	Homo sapiens	228-232
35060381-1	2022	The viral entry process of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires heparin and heparan sulfates from the cell surface, functioning as a cofactor for human angiotensin-converting enzyme 2 (ACE2) for recognizing the receptor-binding domain (RBD) of the spike (S) protein on the surface of the virion.	Heparitin Sulfate	119-135	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	291-296
35114981-3	2022	The encoded exostosin like glycosyltransferase 3 (EXTL3) protein plays a key role in heparan sulfate synthesis.	Heparitin Sulfate	85-100	exostosin like glycosyltransferase 3	Homo sapiens	12-48
35137686-0	2022	Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE.	Heparitin Sulfate	0-15	advanced glycosylation end product-specific receptor	Mus musculus	26-30
35137686-0	2022	Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE.	Heparitin Sulfate	0-15	advanced glycosylation end product-specific receptor	Mus musculus	100-104
35137686-2	2022	Previously we have shown that heparan sulfate (HS) plays an active role in RAGE oligomerization.	Heparitin Sulfate	30-45	advanced glycosylation end product-specific receptor	Mus musculus	75-79
35137686-2	2022	Previously we have shown that heparan sulfate (HS) plays an active role in RAGE oligomerization.	Heparitin Sulfate	47-49	advanced glycosylation end product-specific receptor	Mus musculus	75-79
35137686-7	2022	To test this, we generated a monoclonal antibody that targets the HS-binding site of RAGE.	Heparitin Sulfate	66-68	advanced glycosylation end product-specific receptor	Mus musculus	85-89
35128576-3	2022	In this study, we observed that silencing the expression of syndecan-4, the ubiquitously expressed transmembrane heparan sulfate proteoglycan, significantly enhanced myoblast differentiation, and fusion.	Heparitin Sulfate	113-128	syndecan 4	Homo sapiens	60-70
35114981-3	2022	The encoded exostosin like glycosyltransferase 3 (EXTL3) protein plays a key role in heparan sulfate synthesis.	Heparitin Sulfate	85-100	exostosin like glycosyltransferase 3	Homo sapiens	50-55
35155448-6	2021	NAGLU is a key enzyme for the degradation of heparan sulfate (HS), and its deficiency could cause lysosomal accumulation and lead to dysfunctions of VECs.	Heparitin Sulfate	45-60	N-acetyl-alpha-glucosaminidase	Homo sapiens	0-5
34313252-1	2022	ABSTRACT: Syndecan-1 (SDC-1), a type of heparan sulfate proteoglycan on the surface of epithelial cells, is involved in maintaining cell morphology.	Heparitin Sulfate	40-55	syndecan 1	Homo sapiens	10-20
34313252-1	2022	ABSTRACT: Syndecan-1 (SDC-1), a type of heparan sulfate proteoglycan on the surface of epithelial cells, is involved in maintaining cell morphology.	Heparitin Sulfate	40-55	syndecan 1	Homo sapiens	22-27
35155241-2	2022	Previously published evidence suggested a possible connection between the expression of the membrane-bound heparan sulfate proteoglycan syndecan-1 (Sdc-1) and the development of cervical carcinoma.	Heparitin Sulfate	107-122	ATP binding cassette subfamily A member 1	Homo sapiens	92-106
35155241-2	2022	Previously published evidence suggested a possible connection between the expression of the membrane-bound heparan sulfate proteoglycan syndecan-1 (Sdc-1) and the development of cervical carcinoma.	Heparitin Sulfate	107-122	syndecan 1	Homo sapiens	136-146
35155241-2	2022	Previously published evidence suggested a possible connection between the expression of the membrane-bound heparan sulfate proteoglycan syndecan-1 (Sdc-1) and the development of cervical carcinoma.	Heparitin Sulfate	107-122	syndecan 1	Homo sapiens	148-153
35155448-6	2021	NAGLU is a key enzyme for the degradation of heparan sulfate (HS), and its deficiency could cause lysosomal accumulation and lead to dysfunctions of VECs.	Heparitin Sulfate	62-64	N-acetyl-alpha-glucosaminidase	Homo sapiens	0-5
35071967-4	2022	To investigate the VEGF effect on TC GCX and to elucidate the ultrastructural organization of EC and TC GCX and their alteration by VEGF, we employed super-resolution stochastic optical reconstruction microscopy to observe the spatio-chemical organizations of the heparan sulfate (HS) and hyaluronic acid (HA), two representative GAGs of GCX, on human cerebral microvascular endothelial cells (hCMEC) and malignant breast cancer cells MDA-MB-231 (MB231).	Heparitin Sulfate	264-279	vascular endothelial growth factor A	Homo sapiens	132-136
35073921-0	2022	Histone H4 induces heparan sulfate degradation by activating heparanase in chlorine gas-induced acute respiratory distress syndrome.	Heparitin Sulfate	19-34	LOC102641229	Mus musculus	0-10
35073921-0	2022	Histone H4 induces heparan sulfate degradation by activating heparanase in chlorine gas-induced acute respiratory distress syndrome.	Heparitin Sulfate	19-34	heparanase	Mus musculus	61-71
35073921-16	2022	CONCLUSIONS: Histone H4 is a major pro-inflammatory mediator in Cl2-induced ARDS in mice, and induces HS degradation by activating HPSE via TLRs- and NF-kappaB-signaling pathways.	Heparitin Sulfate	102-104	LOC102641229	Mus musculus	13-23
35073921-16	2022	CONCLUSIONS: Histone H4 is a major pro-inflammatory mediator in Cl2-induced ARDS in mice, and induces HS degradation by activating HPSE via TLRs- and NF-kappaB-signaling pathways.	Heparitin Sulfate	102-104	heparanase	Mus musculus	131-135
35073921-16	2022	CONCLUSIONS: Histone H4 is a major pro-inflammatory mediator in Cl2-induced ARDS in mice, and induces HS degradation by activating HPSE via TLRs- and NF-kappaB-signaling pathways.	Heparitin Sulfate	102-104	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	150-159
35071967-4	2022	To investigate the VEGF effect on TC GCX and to elucidate the ultrastructural organization of EC and TC GCX and their alteration by VEGF, we employed super-resolution stochastic optical reconstruction microscopy to observe the spatio-chemical organizations of the heparan sulfate (HS) and hyaluronic acid (HA), two representative GAGs of GCX, on human cerebral microvascular endothelial cells (hCMEC) and malignant breast cancer cells MDA-MB-231 (MB231).	Heparitin Sulfate	281-283	vascular endothelial growth factor A	Homo sapiens	132-136
34996123-2	2022	HME is caused by mutations in heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2.	Heparitin Sulfate	30-45	exostosin glycosyltransferase 1	Mus musculus	72-76
35054983-6	2022	Compared to the wild-type spike, the Delta one shows a higher affinity towards heparan sulfate proteoglycans than towards ACE2.	Heparitin Sulfate	79-94	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	26-31
35054983-7	2022	In addition to attachment to the polyanionic heparan sulfate chains, the Delta spike"s molecular interactions with syndecan-4 also involve syndecan-4"s cell-binding domain that mediates cell-to-cell adhesion.	Heparitin Sulfate	45-60	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	79-84
35054983-7	2022	In addition to attachment to the polyanionic heparan sulfate chains, the Delta spike"s molecular interactions with syndecan-4 also involve syndecan-4"s cell-binding domain that mediates cell-to-cell adhesion.	Heparitin Sulfate	45-60	syndecan 4	Homo sapiens	115-125
35054983-7	2022	In addition to attachment to the polyanionic heparan sulfate chains, the Delta spike"s molecular interactions with syndecan-4 also involve syndecan-4"s cell-binding domain that mediates cell-to-cell adhesion.	Heparitin Sulfate	45-60	syndecan 4	Homo sapiens	139-149
34999954-6	2022	Although it has been demonstrated that the transporter and substrate specificities of SLC10A7, if any, differ from those of the main members of the protein family, SLC10A7 seems to play a role in Ca2+ regulation and is involved in proper glycosaminoglycan biosynthesis, especially heparan-sulfate, and N-glycosylation.	Heparitin Sulfate	281-296	solute carrier family 10 member 7	Homo sapiens	86-93
34999954-6	2022	Although it has been demonstrated that the transporter and substrate specificities of SLC10A7, if any, differ from those of the main members of the protein family, SLC10A7 seems to play a role in Ca2+ regulation and is involved in proper glycosaminoglycan biosynthesis, especially heparan-sulfate, and N-glycosylation.	Heparitin Sulfate	281-296	solute carrier family 10 member 7	Homo sapiens	164-171
34996123-2	2022	HME is caused by mutations in heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2.	Heparitin Sulfate	30-45	exostosin glycosyltransferase 2	Mus musculus	80-84
34996123-2	2022	HME is caused by mutations in heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2.	Heparitin Sulfate	47-49	exostosin glycosyltransferase 1	Mus musculus	72-76
34996123-2	2022	HME is caused by mutations in heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2.	Heparitin Sulfate	47-49	exostosin glycosyltransferase 2	Mus musculus	80-84
34626386-0	2022	Isolation and Characterization of Heparan Sulfate Containing Amyloid Precursor Protein Degradation Products.	Heparitin Sulfate	34-49	amyloid beta precursor protein	Homo sapiens	61-86
35157288-4	2022	Glypican-2 (GPC2) is a cell surface heparan sulfate proteoglycan with highly tumor-specific expression in neuroblastoma compared with nonmalignant cells.	Heparitin Sulfate	36-51	glypican 2	Homo sapiens	0-10
35157288-4	2022	Glypican-2 (GPC2) is a cell surface heparan sulfate proteoglycan with highly tumor-specific expression in neuroblastoma compared with nonmalignant cells.	Heparitin Sulfate	36-51	glypican 2	Homo sapiens	12-16
35106474-4	2022	Using a highly metastatic renal carcinoma cell line (SN12L1) and its low metastatic counterpart (SN12C) we demonstrate in vitro that the small molecule Suberoylanilide Hydroxamic Acid (SAHA) inhibits the heparan sulfate synthesis enzyme N-deacetylase-N-sulfotransferase-1, reduces heparan sulfate in the glycocalyx and suppresses SN12L1 motility in response to interstitial flow.	Heparitin Sulfate	204-219	N-deacetylase and N-sulfotransferase 1	Homo sapiens	237-271
35106474-4	2022	Using a highly metastatic renal carcinoma cell line (SN12L1) and its low metastatic counterpart (SN12C) we demonstrate in vitro that the small molecule Suberoylanilide Hydroxamic Acid (SAHA) inhibits the heparan sulfate synthesis enzyme N-deacetylase-N-sulfotransferase-1, reduces heparan sulfate in the glycocalyx and suppresses SN12L1 motility in response to interstitial flow.	Heparitin Sulfate	281-296	N-deacetylase and N-sulfotransferase 1	Homo sapiens	237-271
34626412-0	2022	Application of a Mutant Cell Library to Determine the Structure-Function Relationship of Heparan Sulfate in Facilitating FGF2-FGFR1 Signaling.	Heparitin Sulfate	89-104	fibroblast growth factor 2	Mus musculus	121-125
34626412-0	2022	Application of a Mutant Cell Library to Determine the Structure-Function Relationship of Heparan Sulfate in Facilitating FGF2-FGFR1 Signaling.	Heparitin Sulfate	89-104	fibroblast growth factor receptor 1	Mus musculus	126-131
34626417-7	2022	The hyaluronan-HABP complexes are extracted, and the hyaluronan concentration in the tissue is determined using an ELISA-like assay.Historically, heparan sulfate was identified in tissue sections using the cationic dye Alcian blue and histochemistry based on the critical electrolyte concentration principle of differential staining of glycosaminoglycans using salt solutions.	Heparitin Sulfate	146-161	hyaluronan binding protein 2	Homo sapiens	15-19
34626386-1	2022	Numerous studies indicate that heparan sulfate proteoglycans (HSPGs) participate in a network of complex molecular events involving amyloid precursor protein (APP) processing and formation, oligomerization, intracellular targeting, clearance, and propagation of amyloid beta in Alzheimer"s disease (AD).	Heparitin Sulfate	31-46	amyloid beta precursor protein	Homo sapiens	132-157
34626397-1	2022	Extracellular sulfatases (SULF1 and SULF2) selectively remove 6-O-sulfate groups (6OS) from heparan sulfate proteoglycans (HSPGs) and by this process control important interactions of HSPGs with extracellular factors including morphogens, growth factors, and extracellular matrix (ECM) components.	Heparitin Sulfate	92-107	sulfatase 1	Homo sapiens	26-31
34626397-1	2022	Extracellular sulfatases (SULF1 and SULF2) selectively remove 6-O-sulfate groups (6OS) from heparan sulfate proteoglycans (HSPGs) and by this process control important interactions of HSPGs with extracellular factors including morphogens, growth factors, and extracellular matrix (ECM) components.	Heparitin Sulfate	92-107	sulfatase 2	Homo sapiens	36-41
34626399-11	2022	During induction of mEpiSCLCs, we suppressed expression of 3-O-sulfated heparan sulfate (HS), the HS4C3 epitope, by shRNA-mediated knockdown of HS 3-O-sulfotransferases-5 (3OST-5, formally Hs3st5).	Heparitin Sulfate	72-87	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	Mus musculus	189-195
34980815-5	2022	Nonclinical studies showed that pabinafusp alfa was distributed in the brain of hTfR knock-in mice and monkeys after intravenous administration, and dose-dependently decreased heparan sulfate (HS) glycosaminoglycan deposited in major organs including the brain of MPS II mice.	Heparitin Sulfate	176-191	transferrin receptor	Homo sapiens	80-84
34980815-5	2022	Nonclinical studies showed that pabinafusp alfa was distributed in the brain of hTfR knock-in mice and monkeys after intravenous administration, and dose-dependently decreased heparan sulfate (HS) glycosaminoglycan deposited in major organs including the brain of MPS II mice.	Heparitin Sulfate	193-195	transferrin receptor	Homo sapiens	80-84
35224154-2	2022	HRGP ligands includes heme, Zn2+, thrombospondin, plasmin/plasminogen, heparin/heparan sulfate, fibrinogen, tropomyosin, IgG, FcgammaR, C1q.	Heparitin Sulfate	79-94	histidine rich glycoprotein	Homo sapiens	0-4
35224154-6	2022	The most common cell surface ligand of HRGP is heparan sulfate proteoglycan, and the interaction is also potentiated by elevated Zn2+ concentration and low pH.	Heparitin Sulfate	47-62	histidine rich glycoprotein	Homo sapiens	39-43