PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33340948-2	2021	In C3-C5 diols biological processes of 1,3-propanediol, 1,2-propanediol and 2,3-butanediol have been commercialized as other isomers are non-natural metabolites and lack natural biosynthetic pathways.	1,3-propanediol	39-54	ADAM metallopeptidase with thrombospondin type 1 motif 1	Homo sapiens	3-8
5782352-2	1969	The cyclic acetal derivatives of the alk-1-enyl groups were made by treating the ethanolamine phosphoglycerides with 1,3-propanediol.	1,3-propanediol	117-132	activin A receptor, type II-like 1	Mus musculus	37-42
33248828-6	2021	The best 1,3-propanediol yield of 32.8% at 78% glycerol conversion were achieved over the 5Pt/WOx/L-Al2O3 under optimal reaction condition of 220  C, 6 MPa, 5 h reaction time and amount of catalyst to glycerol ratio of 0.25 g mL-1.	1,3-propanediol	9-24	L1 cell adhesion molecule	Mus musculus	226-230
6069715-2	1967	Action of a phospholipase A on phospholipids containing trimethylene-glycol].	1,3-propanediol	56-75	phospholipase A and acyltransferase 1	Homo sapiens	12-27
33256040-5	2020	It was observed that a volume of 84 mL of ethanol 75% loaded with a flow rate of 7 mL/min completely remove the secondary metabolites from 10 mL of concentrated fermented broth, and pure biogenic 1,3-PD was recovered in 128 mL of the eluent.	1,3-propanediol	196-202	thrombopoietin	Mus musculus	36-38
30966634-0	2018	Synthesis and Characterization of Renewable Polyester Coil Coatings from Biomass-Derived Isosorbide, FDCA, 1,5-Pentanediol, Succinic Acid, and 1,3-Propanediol.	1,3-propanediol	143-158	coilin	Homo sapiens	54-58
29644593-4	2018	The HPr was the main metabolite produced, increasing in composition from 66.5 to 99.6% by decreasing the HRT from 8 to 0.5 h. Other metabolic products were 1,3-propanediol, with a maximum of 29.4% with an HRT of 6 h, ethanol, acetic, and butyric acids.	1,3-propanediol	156-171	haptoglobin-related protein	Homo sapiens	4-7
31603652-8	2019	In addition to proof-of-concept we further improved the host strain by deleting a gene (frmA) responsible for the conversion of HCHO to formate, thereby increasing the production of 1,3-PDO from 298.3 +- 11.4 mg/L to 508.3 +- 9.1 mg/L and from 3.8 mg/L to 32.7 +- 0.8 mg/L with HCHO and methanol as co-substrate of glucose fermentation, respectively.	1,3-propanediol	182-189	alcohol dehydrogenase class-III	Escherichia coli	88-92
30925016-1	2019	Phosphoserine aminotransferase (SerC) from Escherichia coli (E. coli) MG1655 is engineered to catalyze the deamination of homoserine to 4-hydroxy-2-ketobutyrate, a key reaction in producing 1,3-propanediol (1,3-PDO) from glucose in a novel glycerol-independent metabolic pathway.	1,3-propanediol	190-205	phosphoserine/phosphohydroxythreonine aminotransferase	Escherichia coli str. K-12 substr. MG1655	32-36
30925016-1	2019	Phosphoserine aminotransferase (SerC) from Escherichia coli (E. coli) MG1655 is engineered to catalyze the deamination of homoserine to 4-hydroxy-2-ketobutyrate, a key reaction in producing 1,3-propanediol (1,3-PDO) from glucose in a novel glycerol-independent metabolic pathway.	1,3-propanediol	207-214	phosphoserine/phosphohydroxythreonine aminotransferase	Escherichia coli str. K-12 substr. MG1655	32-36
29534944-5	2018	However CPF supplemented with xylan strongly enhanced the transcription levels of the major enzymes of 1,3-PD production (glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase).	1,3-propanediol	103-109	gldA	Clostridium butyricum	122-201
27570311-6	2016	Additionally, under shake-flask conditions, the strain coexpressing Ald4 and rpoE produced 0.5 g 3-hydroxypropionic acid (3-HP) and 9.8 g 1,3-propanediol (1,3-PD) per liter in 24 h, which were 1.6- and 0.85-fold enhancement, respectively, compared to those expressing Ald4 alone.	1,3-propanediol	155-161	aldehyde dehydrogenase (NADP(+)) ALD4	Saccharomyces cerevisiae S288C	68-72
30060420-0	2018	Production of 1,3-propanediol using a novel 1,3-propanediol dehydrogenase from isolated Clostridium butyricum and co-biotransformation of whole cells.	1,3-propanediol	14-29	ATN24_RS18670	Clostridium butyricum	44-73
28476770-8	2017	Lastly, the potential of PhaP and GroEL to enhance the accumulation of ethanol or 1,3-propanediol was analyzed in recombinant E. coli Strains that overexpressed either groEL or phaP had increased growth, reflected in a higher final biomass and product titer than the control strain.	1,3-propanediol	82-97	GroEL	Escherichia coli	34-39
28476770-11	2017	Additionally, both the PhaP phasin and the well-known chaperone GroEL were used to increase the biosynthesis of the biotechnologically relevant compounds ethanol and 1,3-propanediol in recombinant E. coli These findings open the road for the use of these proteins for the manipulation of bacterial strains to optimize the synthesis of diverse bioproducts from renewable carbon sources.	1,3-propanediol	166-181	GroEL	Escherichia coli	64-69
27570311-7	2016	Notably, under non-optimized bioreactor conditions, the strain coexpressing Ald4 and rpoE produced 13.5 g 3-HP and 37.8 g 1,3-PD per liter with glycerol conversion ratio of 0.45 mol/mol.	1,3-propanediol	122-128	aldehyde dehydrogenase (NADP(+)) ALD4	Saccharomyces cerevisiae S288C	76-80
27213050-0	2016	1,3-Propanediol binds inside the water-conducting pore of aquaporin 4: Does this efficacious inhibitor have sufficient potency?	1,3-propanediol	0-15	aquaporin 4	Homo sapiens	58-69
26914368-3	2016	This newly prepared catalyst exhibited outstanding hydrogenolysis activity under 1 MPa H2 pressure with a very high space-time yield towards 1,3-propanediol (3.78 g gPt (-1)  h(-1) ) in Pt-W catalysts.	1,3-propanediol	141-156	glutamic--pyruvic transaminase	Homo sapiens	165-172
26481430-5	2016	Using this validated computational method, we found that 1,3-propanediol (PDO) binds deep inside the AQP4 channel to inhibit that particular aquaporin efficaciously.	1,3-propanediol	57-72	aquaporin 4	Homo sapiens	101-105
26481430-5	2016	Using this validated computational method, we found that 1,3-propanediol (PDO) binds deep inside the AQP4 channel to inhibit that particular aquaporin efficaciously.	1,3-propanediol	74-77	aquaporin 4	Homo sapiens	101-105
27213050-6	2016	We compute the binding affinities of 1,2-ethanediol (EDO) and 1,3-propanediol (PDO) inside the AQP4 conducting pore and identify the specificities of the interactions.	1,3-propanediol	62-77	aquaporin 4	Homo sapiens	95-99
27213050-9	2016	Considering the fact that PDO is classified by the US Food and Drug Administration as generally safe, we predict that 1,3-propanediol could be an effective drug for brain edema and other AQP4-correlated neurological conditions.	1,3-propanediol	118-133	aquaporin 4	Homo sapiens	187-191
25082272-2	2014	It is shown that the unique organometallic complex [Rh(OTf)(trop2NH)(PPh3)] employed as molecular active site in an anode of an OMFC selectively oxidizes a number of renewable diols, such as ethylene glycol , 1,2-propanediol (1,2-P), 1,3-propanediol (1,3-P), and 1,4-butanediol (1,4-B) to their corresponding mono-carboxylates.	1,3-propanediol	234-249	caveolin 1	Homo sapiens	69-73
25173613-6	2014	VF1 and VF2 were found in all 9 sequenced strains and the 1,3-propanediol-producing strain KG1.	1,3-propanediol	58-73	dipeptidyl peptidase like 6	Homo sapiens	8-11
25173613-7	2014	When the VF2 fragment was knocked out in KG1, cell growth and 1,3-propanediol production in the mutant were nearly the same as in KG1.	1,3-propanediol	62-77	dipeptidyl peptidase like 6	Homo sapiens	9-12
25082272-2	2014	It is shown that the unique organometallic complex [Rh(OTf)(trop2NH)(PPh3)] employed as molecular active site in an anode of an OMFC selectively oxidizes a number of renewable diols, such as ethylene glycol , 1,2-propanediol (1,2-P), 1,3-propanediol (1,3-P), and 1,4-butanediol (1,4-B) to their corresponding mono-carboxylates.	1,3-propanediol	251-256	caveolin 1	Homo sapiens	69-73
21311687-6	2010	These data suggest that the amide group of B13 could be replaced by thiourea, that the stereochemistry of 1,3-propandiol may not be essential for activity and that long alkyl chains increase cytotoxicity.	1,3-propanediol	106-120	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	43-46
22053913-0	2011	Glycerol conversion to 1, 3-Propanediol is enhanced by the expression of a heterologous alcohol dehydrogenase gene in Lactobacillus reuteri.	1,3-propanediol	23-39	Alcohol dehydrogenase	Escherichia coli	88-109
22053913-1	2011	In this work, Lactobacillus reuteri has been metabolically engineered for improving 1, 3-propanediol (1, 3-PD) production by the expression of an Escherichia coli alcohol dehydrogenase, yqhD, that is known to efficiently convert the precursor 3-hydroxypropionaldehyde (3-HPA) to 1, 3-PD.	1,3-propanediol	84-100	Alcohol dehydrogenase	Escherichia coli	163-184
21995522-0	2012	Klebsiella spp as a 1, 3-propanediol producer: the metabolic engineering approach.	1,3-propanediol	20-36	histocompatibility minor 13	Homo sapiens	11-14
21995522-1	2012	Klebsiella spp are one of the best natural producers of 1,3-propanediol (1,3-PD).	1,3-propanediol	56-71	histocompatibility minor 13	Homo sapiens	11-14
21995522-1	2012	Klebsiella spp are one of the best natural producers of 1,3-propanediol (1,3-PD).	1,3-propanediol	73-79	histocompatibility minor 13	Homo sapiens	11-14
21995522-3	2012	Nevertheless, multiple advantageous traits of Klebsiella spp justify the international effort devoted to develop a biotechnological process of 1,3-PD production with these microorganisms.	1,3-propanediol	143-149	histocompatibility minor 13	Homo sapiens	57-60
21995522-4	2012	Apart from the process engineering approach aiming at improvement of 1,3-PD production by Klebsiella spp, plethora of metabolic engineering approaches have been reported.	1,3-propanediol	69-75	histocompatibility minor 13	Homo sapiens	101-104
21995522-7	2012	This review provides an overview of the initial and most recent reports on the metabolic engineering of Klebsiella spp with the aim of improvement of 1,3-PD biosynthesis.	1,3-propanediol	150-156	histocompatibility minor 13	Homo sapiens	115-118
21360149-7	2011	Finally, with the optimal flow rate of 10 ml min(-1) and loading amount of 80 ml, the yield of 1,3-propanediol achieved was 89%.	1,3-propanediol	95-110	CD59 molecule (CD59 blood group)	Homo sapiens	45-51
20124718-1	2010	1,3-Propanediol dehydrogenase is an enzyme that catalyzes the oxidation of 1,3-propanediol to 3-hydroxypropanal with the simultaneous reduction of NADP(+) to NADPH.	1,3-propanediol	75-90	dhaT	Aquifex aeolicus VF5	0-29
20362437-1	2010	In this paper, we introduced a polydiol (mixture of 1,2-propanediol, 1,3-propanediol, and 2,3-butanediol) to improve the covalent crosslinking adsorption process of immobilized catalase onto chitosan beads.	1,3-propanediol	69-84	catalase	Homo sapiens	177-185
10677220-9	2000	The results also show that AP site analogues such as 1, 3-propanediol (Pr), tetrahydrofuran (F), or cyclopentanol (Cy) are not substrates but constitute good inhibitors of the wild-type yOgg1.	1,3-propanediol	53-69	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	186-191
10866613-1	2000	A new synthetic approach to polycyclic aromatic compounds is described that entails in the key steps double Suzuki coupling of PAH bisboronic acid derivatives with o-bromoaryl aldehydes to furnish aryl dialdehydes that are converted to larger polycyclic aromatic ring systems by either (a) conversion to diolefins by Wittig reaction followed by photocyclization or (b) reductive cyclization with triflic acid and 1,3-propanediol.	1,3-propanediol	413-428	phenylalanine hydroxylase	Homo sapiens	127-130
11795885-4	2002	Other polyols such as sucrose, 1,2-propanediol, or 1,3-propanediol also facilitated nucleotide-independent refolding of GS from chaperonin complex.	1,3-propanediol	51-66	glutamate-ammonia ligase	Homo sapiens	120-122
11784166-3	2001	The serine protease subtilisin Carlsberg (EC 3.4.21.62) was found to efficiently catalyze the specific formation of C(alpha)-carboxyl 3-hydroxypropyl or 4-hydroxybutyl esters of certain Boc-amino acids and peptides in high-content 1,3-propanediol or 1,4-butanediol solution, with substrate specificity parallel to that of the normal hydrolytic reaction.	1,3-propanediol	231-246	coagulation factor II, thrombin	Homo sapiens	4-19
9633649-4	1998	The apparent K(m)s for the glycerol dehydrogenase was 16-fold higher for the glycerol than that for the glyceraldehyde in the case of the glyceraldehyde-3-phosphate dehydrogenase and fourfold higher for the NAD+, providing an explanation for the shift of the glycerol flow toward 1,3-propanediol when cells were grown on glucose-glycerol mixtures.	1,3-propanediol	280-295	gldA	Clostridium butyricum	27-49