PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33100863-7 2020 The IL-18BP elevation in ATB group was accompanied by an increase in IL-18. 4-anisyltetrazolium blue 25-28 interleukin 18 binding protein Homo sapiens 4-11 33100863-7 2020 The IL-18BP elevation in ATB group was accompanied by an increase in IL-18. 4-anisyltetrazolium blue 25-28 interleukin 18 Homo sapiens 4-9 31140621-10 2019 Moreover, both the NF-kappaB selected inhibitor pyrrolidinedithiocarbamate ammonium and P38/MAPK specific inhibitor SB203580 partly reversed lncRNA-ATB induced glioma cells invasion mediated by TGF-beta. 4-anisyltetrazolium blue 148-151 mitogen-activated protein kinase 14 Homo sapiens 88-91 32379840-9 2020 Prophylactic ATB 60 minutes prior the surgery was significantly more used in GII than GI (99.2% vs 87.4%, p < 0.001). 4-anisyltetrazolium blue 13-16 G protein subunit alpha i1 Homo sapiens 77-79 32379840-10 2020 In addition, ATB suspension within 48 hours was significantly more frequent in GII than GI (84.7% vs. 51.6%, p < 0.001). 4-anisyltetrazolium blue 13-16 G protein subunit alpha i1 Homo sapiens 79-81 31532894-6 2020 Four proteins (KYAT3, SERPINA1, HP and APOC3) showed deregulation (log2 fold change >+-0.48, p < 0.05) in ATB with respect to healthy controls and Western blot data corroborated mass spectrometry findings. 4-anisyltetrazolium blue 112-115 kynurenine aminotransferase 3 Homo sapiens 15-20 31532894-6 2020 Four proteins (KYAT3, SERPINA1, HP and APOC3) showed deregulation (log2 fold change >+-0.48, p < 0.05) in ATB with respect to healthy controls and Western blot data corroborated mass spectrometry findings. 4-anisyltetrazolium blue 112-115 serpin family A member 1 Homo sapiens 22-30 31532894-6 2020 Four proteins (KYAT3, SERPINA1, HP and APOC3) showed deregulation (log2 fold change >+-0.48, p < 0.05) in ATB with respect to healthy controls and Western blot data corroborated mass spectrometry findings. 4-anisyltetrazolium blue 112-115 apolipoprotein C3 Homo sapiens 39-44 31140621-10 2019 Moreover, both the NF-kappaB selected inhibitor pyrrolidinedithiocarbamate ammonium and P38/MAPK specific inhibitor SB203580 partly reversed lncRNA-ATB induced glioma cells invasion mediated by TGF-beta. 4-anisyltetrazolium blue 148-151 transforming growth factor beta 1 Homo sapiens 194-202 30942415-8 2019 Expression of TGF-beta1 and pro-apoptotic Caspase-3 in lncRNA-ATB-overexpressing HUVECs was detected by western blotting. 4-anisyltetrazolium blue 62-65 transforming growth factor beta 1 Homo sapiens 14-23 30942415-8 2019 Expression of TGF-beta1 and pro-apoptotic Caspase-3 in lncRNA-ATB-overexpressing HUVECs was detected by western blotting. 4-anisyltetrazolium blue 62-65 caspase 3 Homo sapiens 42-51 30771739-11 2019 Further, the signaling pathway experiments showed that lncRNA-ATB inhibited MyD88/NF-kappaB and p38MAPK pathways by down-regulating miR-223 in LPS-injured cells. 4-anisyltetrazolium blue 62-65 microRNA 223 Mus musculus 132-139 30842737-10 2019 GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels. 4-anisyltetrazolium blue 12-15 myeloperoxidase Homo sapiens 78-93 30771739-11 2019 Further, the signaling pathway experiments showed that lncRNA-ATB inhibited MyD88/NF-kappaB and p38MAPK pathways by down-regulating miR-223 in LPS-injured cells. 4-anisyltetrazolium blue 62-65 myeloid differentiation primary response gene 88 Mus musculus 76-81 30771739-11 2019 Further, the signaling pathway experiments showed that lncRNA-ATB inhibited MyD88/NF-kappaB and p38MAPK pathways by down-regulating miR-223 in LPS-injured cells. 4-anisyltetrazolium blue 62-65 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 82-91 30771739-11 2019 Further, the signaling pathway experiments showed that lncRNA-ATB inhibited MyD88/NF-kappaB and p38MAPK pathways by down-regulating miR-223 in LPS-injured cells. 4-anisyltetrazolium blue 62-65 mitogen-activated protein kinase 14 Mus musculus 96-103 30842737-10 2019 GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels. 4-anisyltetrazolium blue 12-15 myeloperoxidase Homo sapiens 95-98 30842737-10 2019 GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels. 4-anisyltetrazolium blue 12-15 interleukin 1 beta Homo sapiens 151-159 30842737-10 2019 GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels. 4-anisyltetrazolium blue 12-15 C-C motif chemokine ligand 2 Homo sapiens 164-194 30842737-10 2019 GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels. 4-anisyltetrazolium blue 12-15 myeloperoxidase Homo sapiens 276-279 30842737-10 2019 GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels. 4-anisyltetrazolium blue 12-15 interleukin 6 Homo sapiens 293-297 25986864-8 2015 miR-200c levels were lower and ZEB1 levels were higher in the high lncRNA-ATB group than in the low lncRNA-ATB group. 4-anisyltetrazolium blue 74-77 microRNA 200c Homo sapiens 0-8 27267902-0 2016 Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a. 4-anisyltetrazolium blue 20-23 microRNA 200a Homo sapiens 76-84 27267902-9 2016 In addition, ATB was confirmed to target miR-200a, and miR-200a inhibition reversed the malignant characteristics of ATB knockdown on glioma cells. 4-anisyltetrazolium blue 13-16 microRNA 200a Homo sapiens 41-49 27267902-9 2016 In addition, ATB was confirmed to target miR-200a, and miR-200a inhibition reversed the malignant characteristics of ATB knockdown on glioma cells. 4-anisyltetrazolium blue 117-120 microRNA 200a Homo sapiens 55-63 27267902-10 2016 In particular, ATB may act as a ceRNA, effectively becoming a sink for miR-200a, thereby modulating the derepression of TGF-beta2. 4-anisyltetrazolium blue 15-18 microRNA 200a Homo sapiens 71-79 27267902-10 2016 In particular, ATB may act as a ceRNA, effectively becoming a sink for miR-200a, thereby modulating the derepression of TGF-beta2. 4-anisyltetrazolium blue 15-18 transforming growth factor beta 2 Homo sapiens 120-129 27267902-11 2016 CONCLUSIONS: Our findings suggest that ATB plays an oncogenic role of glioma cells by inhibiting miR-200a and facilitating TGF-beta2 in glioma, thereby may represent a potential therapeutic target for the treatment of human glioma. 4-anisyltetrazolium blue 39-42 microRNA 200a Homo sapiens 97-105 27267902-11 2016 CONCLUSIONS: Our findings suggest that ATB plays an oncogenic role of glioma cells by inhibiting miR-200a and facilitating TGF-beta2 in glioma, thereby may represent a potential therapeutic target for the treatment of human glioma. 4-anisyltetrazolium blue 39-42 transforming growth factor beta 2 Homo sapiens 123-132 26959228-5 2016 RESULTS: There were significant differences in median CD4+ T-cell counts between HIV-1+ATB (164/muL), HIV-1+LTB (447/muL) and HIV-1+TB- (329/muL) groups. 4-anisyltetrazolium blue 87-90 CD4 molecule Homo sapiens 54-57 26959228-8 2016 Immunologically, HIV-1+ATB group showed significantly lower numbers of ESAT-6-/CFP-10-specific IFN-gamma+ T cells than HIV-1+LTB group. 4-anisyltetrazolium blue 23-26 interferon gamma Homo sapiens 95-104 26959228-9 2016 Consistently, PPD-specific IFN-gamma+CD4+/CD8+ T effector cells in HIV-1+ATB group were significantly lower than those in HIV-1+LTB group (P<0.001). 4-anisyltetrazolium blue 73-76 interferon gamma Homo sapiens 27-36 26959228-9 2016 Consistently, PPD-specific IFN-gamma+CD4+/CD8+ T effector cells in HIV-1+ATB group were significantly lower than those in HIV-1+LTB group (P<0.001). 4-anisyltetrazolium blue 73-76 CD4 molecule Homo sapiens 37-40 26959228-9 2016 Consistently, PPD-specific IFN-gamma+CD4+/CD8+ T effector cells in HIV-1+ATB group were significantly lower than those in HIV-1+LTB group (P<0.001). 4-anisyltetrazolium blue 73-76 CD8a molecule Homo sapiens 42-45 30705350-9 2019 The identified sputum protein signature is a promising panel to differentiate ATB from NTB groups and suggest a deregulated DBP-AMP axis in lungs of tuberculosis patients. 4-anisyltetrazolium blue 78-81 D-box binding PAR bZIP transcription factor Homo sapiens 124-127 29928386-7 2018 Tetrazolium blue (MTT) method was employed to detect the effect of p57 inhibition on the proliferation of the MCF-7 and SHZ-88 cell lines. 4-anisyltetrazolium blue 0-16 cyclin dependent kinase inhibitor 1C Homo sapiens 67-70 29375050-11 2017 ATB-346 significantly increased Nrf-2 and HO-1 protein expression as compared with vehicle (P < 0.05) but did not affect the protein expression of CSE, CBS, 3-MST or HIF-1alpha. 4-anisyltetrazolium blue 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 32-37 29375050-11 2017 ATB-346 significantly increased Nrf-2 and HO-1 protein expression as compared with vehicle (P < 0.05) but did not affect the protein expression of CSE, CBS, 3-MST or HIF-1alpha. 4-anisyltetrazolium blue 0-3 heme oxygenase 1 Homo sapiens 42-46 29375050-12 2017 ATB-346 but not naproxen decreased COX-2 protein expression in gastric mucosa compromised by WRS (p < 0.05). 4-anisyltetrazolium blue 0-3 mitochondrially encoded cytochrome c oxidase II Homo sapiens 35-40 29375050-14 2017 ATB-346 but not naproxen decreased plasma content of IL-1alpha, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-alpha and IFN-gamma in rats exposed to WRS (p < 0.05). 4-anisyltetrazolium blue 0-3 interleukin 1 alpha Rattus norvegicus 53-62 29375050-14 2017 ATB-346 but not naproxen decreased plasma content of IL-1alpha, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-alpha and IFN-gamma in rats exposed to WRS (p < 0.05). 4-anisyltetrazolium blue 0-3 interleukin 4 Rattus norvegicus 64-68 29375050-14 2017 ATB-346 but not naproxen decreased plasma content of IL-1alpha, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-alpha and IFN-gamma in rats exposed to WRS (p < 0.05). 4-anisyltetrazolium blue 0-3 interleukin 5 Rattus norvegicus 70-74 29375050-14 2017 ATB-346 but not naproxen decreased plasma content of IL-1alpha, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-alpha and IFN-gamma in rats exposed to WRS (p < 0.05). 4-anisyltetrazolium blue 0-3 interleukin 6 Rattus norvegicus 76-80 29375050-14 2017 ATB-346 but not naproxen decreased plasma content of IL-1alpha, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-alpha and IFN-gamma in rats exposed to WRS (p < 0.05). 4-anisyltetrazolium blue 0-3 interleukin 10 Rattus norvegicus 82-87 29375050-14 2017 ATB-346 but not naproxen decreased plasma content of IL-1alpha, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-alpha and IFN-gamma in rats exposed to WRS (p < 0.05). 4-anisyltetrazolium blue 0-3 interleukin 12B Rattus norvegicus 89-94 29375050-14 2017 ATB-346 but not naproxen decreased plasma content of IL-1alpha, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-alpha and IFN-gamma in rats exposed to WRS (p < 0.05). 4-anisyltetrazolium blue 0-3 tumor necrosis factor Rattus norvegicus 96-105 29375050-14 2017 ATB-346 but not naproxen decreased plasma content of IL-1alpha, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-alpha and IFN-gamma in rats exposed to WRS (p < 0.05). 4-anisyltetrazolium blue 0-3 interferon gamma Rattus norvegicus 110-119 29375050-16 2017 In contrast to naproxen, ATB-346 decreased stress-induced systemic inflammation and pro-inflammatory COX-2 expression in the gastric mucosa. 4-anisyltetrazolium blue 25-28 mitochondrially encoded cytochrome c oxidase II Homo sapiens 101-106 29375050-17 2017 The decreased gastrotoxicity of ATB-346 could be due to upregulation of Nrf-2/HO-1 pathway mediated by the release of H2s. 4-anisyltetrazolium blue 32-35 NFE2 like bZIP transcription factor 2 Homo sapiens 72-77 29375050-17 2017 The decreased gastrotoxicity of ATB-346 could be due to upregulation of Nrf-2/HO-1 pathway mediated by the release of H2s. 4-anisyltetrazolium blue 32-35 heme oxygenase 1 Homo sapiens 78-82 28640252-0 2017 Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis. 4-anisyltetrazolium blue 20-23 microRNA 200b Homo sapiens 96-104 28640252-0 2017 Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis. 4-anisyltetrazolium blue 20-23 FERM domain containing kindlin 2 Homo sapiens 105-114 27176634-8 2016 In addition, lncRNA-ATB stimulated epithelial-mesenchymal transition (EMT) associated with ZEB1 and ZNF217 expression levels via ERK and PI3K/AKT signaling pathways. 4-anisyltetrazolium blue 20-23 zinc finger E-box binding homeobox 1 Homo sapiens 91-95 27176634-8 2016 In addition, lncRNA-ATB stimulated epithelial-mesenchymal transition (EMT) associated with ZEB1 and ZNF217 expression levels via ERK and PI3K/AKT signaling pathways. 4-anisyltetrazolium blue 20-23 zinc finger protein 217 Homo sapiens 100-106 25986864-8 2015 miR-200c levels were lower and ZEB1 levels were higher in the high lncRNA-ATB group than in the low lncRNA-ATB group. 4-anisyltetrazolium blue 74-77 zinc finger E-box binding homeobox 1 Homo sapiens 31-35 24802247-4 2014 Cationic amino acids are transported by several cationic transport systems including, ATB(0,+) (SLC6A14), which is upregulated in certain human cancers including cervical, colorectal and estrogen receptor-positive breast cancer. 4-anisyltetrazolium blue 86-89 solute carrier family 6 member 14 Homo sapiens 96-103 24802247-11 2014 In conclusion, the non-natural cationic amino acid PET probe [(18)F]FEMAET accumulates in cancer cells in vitro and in vivo with possible involvement of ATB(0,+). 4-anisyltetrazolium blue 153-156 thyroid stimulating hormone receptor Mus musculus 51-54 20128814-10 2010 In a mouse airpouch model, ATB-346 suppressed cyclooxygenase-2 activity and inhibited leukocyte infiltration more effectively than naproxen. 4-anisyltetrazolium blue 27-30 prostaglandin-endoperoxide synthase 2 Mus musculus 46-62 24307544-8 2014 As expected for ATB(0,+) transport, uptake was inhibited by LAT/ATB(0,+) inhibitors and dibasic amino acids, and [(18)F]FEMAET efflux was only moderately stimulated by extracellular amino acids. 4-anisyltetrazolium blue 16-19 linker for activation of T cells Homo sapiens 60-63 23420441-3 2013 Then, relevant changes in the biological characteristics of the BTG2-expressing cell line were analyzed using MTT (tetrazolium blue), flow cytometry, and Transwell invasion chamber assays. 4-anisyltetrazolium blue 115-131 BTG anti-proliferation factor 2 Homo sapiens 64-68 21771784-1 2011 SLC6A14, also known as ATB(0,+), is an amino acid transporter with unique characteristics. 4-anisyltetrazolium blue 23-26 solute carrier family 6 member 14 Homo sapiens 0-7 24823859-4 2014 Due to potential protein kinase C (PKC) phosphorylation sites within ATB(0,+) sequence, the present study verified effects of this kinase on transporter function and localization in the BBB. 4-anisyltetrazolium blue 69-72 proline rich transmembrane protein 2 Homo sapiens 17-33 24823859-4 2014 Due to potential protein kinase C (PKC) phosphorylation sites within ATB(0,+) sequence, the present study verified effects of this kinase on transporter function and localization in the BBB. 4-anisyltetrazolium blue 69-72 proline rich transmembrane protein 2 Homo sapiens 35-38 24823859-5 2014 ATB(0,+) can be regulated by estrogen receptor alpha and up-regulated in vitro, therefore its presence in vivo was verified with the transmission electron microscopy. 4-anisyltetrazolium blue 0-3 estrogen receptor 1 Homo sapiens 29-52 24823859-8 2014 ATB(0,+) was phosphorylated by PKC, what correlated with inhibition of carnitine transport. 4-anisyltetrazolium blue 0-3 proline rich transmembrane protein 2 Homo sapiens 31-34 24823634-2 2014 In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-beta-induced lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis. 4-anisyltetrazolium blue 99-102 IL2 inducible T cell kinase Homo sapiens 121-124 24823634-2 2014 In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-beta-induced lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis. 4-anisyltetrazolium blue 99-102 interleukin 11 Homo sapiens 199-204 16855178-5 2006 In healthy rats, ATB-429 dose dependently (25, 50, or 100 mg/kg) attenuated CRD-induced hypersensitivity and significantly inhibited CRD-induced overexpression of spinal c-FOS mRNA, whereas mesalamine had no effect. 4-anisyltetrazolium blue 17-20 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 170-175 17341550-7 2007 Bio-LC-ATB-BGPA-labeling of GLUT4 was saturable and competitively inhibited by d-glucose. 4-anisyltetrazolium blue 6-10 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 28-33 17341550-8 2007 Stimulation of glucose uptake by insulin in the perfused heart was associated with parallel increases in bio-LC-ATB-BGPA-labeling of cell surface GLUT4. 4-anisyltetrazolium blue 112-115 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 146-151 17855766-17 2007 ATB(0,+) may mediate intestinal absorption of BC when OCTN2 is defective. 4-anisyltetrazolium blue 0-3 solute carrier family 22 member 5 Homo sapiens 54-59 16855178-9 2006 Colonic cyclooxygenase-2 and interkeukin-1beta mRNA and spinal c-FOS mRNA expression were significantly down-regulated by ATB-429, but not by mesalamine. 4-anisyltetrazolium blue 122-125 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 8-24 16855178-9 2006 Colonic cyclooxygenase-2 and interkeukin-1beta mRNA and spinal c-FOS mRNA expression were significantly down-regulated by ATB-429, but not by mesalamine. 4-anisyltetrazolium blue 122-125 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 63-68 15905073-1 2005 ATB(0,+) (SLC6A14) is a Na(+)/Cl(-)-coupled arginine transporter expressed at low levels in normal colon. 4-anisyltetrazolium blue 0-3 solute carrier family 6 member 14 Homo sapiens 10-17 9176187-3 1997 Likewise, basal ATB-BMPA-labeled GLUT-4 was not altered in these muscles with training. 4-anisyltetrazolium blue 16-19 solute carrier family 2 member 4 Rattus norvegicus 33-39 11306651-21 2001 In contrast, ATB(0,+) is a low-affinity transporter for carnitine, but exhibits much higher concentrative capacity than OCTN2 because of its energization by transmembrane gradients of Na(+) and Cl(-) as well as by membrane potential. 4-anisyltetrazolium blue 13-16 solute carrier family 22 member 5 L homeolog Xenopus laevis 120-125 7943226-1 1994 The acute effect of insulin-like growth factor I (IGF-I) and insulin on glucose uptake and the glucose transport system in in vitro incubated rat soleus muscles was examined using 3-O-methylglucose and the ATB-[3H]BMPA exofacial photolabeling technique. 4-anisyltetrazolium blue 206-209 insulin-like growth factor 1 Rattus norvegicus 20-48 7943226-1 1994 The acute effect of insulin-like growth factor I (IGF-I) and insulin on glucose uptake and the glucose transport system in in vitro incubated rat soleus muscles was examined using 3-O-methylglucose and the ATB-[3H]BMPA exofacial photolabeling technique. 4-anisyltetrazolium blue 206-209 insulin-like growth factor 1 Rattus norvegicus 50-55 8262190-4 1993 [125I-Tyr2,Nle4,D-Phe7,ATB-Lys11]-alpha-MSH photoaffinity labelled proteins from Schwann cells were analyzed by SDS-PAGE followed by autoradiography. 4-anisyltetrazolium blue 23-26 proopiomelanocortin Rattus norvegicus 34-43 33721714-10 2021 ATB+ calves had higher levels of haptoglobin (P = 0.032) on days 13-15. 4-anisyltetrazolium blue 0-3 haptoglobin Bos taurus 33-44 33573644-15 2021 CONCLUSION: The preliminary clinical, radiographical, and histological results of Bonmaker autogenous tooth graft therapy indicate that ATB may be safely and successfully used as a grafting material for ARP. 4-anisyltetrazolium blue 137-140 mesencephalic astrocyte derived neurotrophic factor Homo sapiens 204-207