PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30430911-7	2021	Conversely, inhibition of astrocytes by fluorocitrate (FC) pretreatment resulted in the improved neurological function and memory, as well as downregulation of IL-15 and CD8 T cells, and decreased neuronal apoptosis.	fluorocitrate	55-57	interleukin 15	Rattus norvegicus	160-165
2818568-7	1989	Only C16, C14 and C12 intermediates were detected in uncoupled mitochondria oxidizing [U-14C]hexadecanoyl-CoA in the presence of fluorocitrate and carnitine, providing evidence for some organization of the enzymes of beta-oxidation [Garland, Shepherd & Yates (1965) Biochem.	fluorocitrate	129-142	anti-Mullerian hormone receptor type 2	Rattus norvegicus	10-13
2881415-7	1986	Additive inhibition of aspartate accumulation by fluorocitrate and (-) hydroxyacetate shows that, in addition to the tricarboxylic acid cycle, the reaction catalysed by ATP-citrate lyase serves in the synaptosomes as another source of oxaloacetate.	fluorocitrate	49-62	ATP citrate lyase	Rattus norvegicus	169-186
30430911-7	2021	Conversely, inhibition of astrocytes by fluorocitrate (FC) pretreatment resulted in the improved neurological function and memory, as well as downregulation of IL-15 and CD8 T cells, and decreased neuronal apoptosis.	fluorocitrate	40-53	interleukin 15	Rattus norvegicus	160-165
32611425-17	2020	Pretreatment IL-10tm1/tm1 mice with IL-10 or fluorocitrate decreased the expression of proinflammatory factors and A1-specific transcripts in the hippocampus and cortex, and then alleviated LPS-induced depressive-like behavior.	fluorocitrate	45-58	interleukin 10	Mus musculus	13-18
32767851-10	2021	Furthermore, we found that fluorocitrate administration at 3 days after ETM could markedly suppress the expression of c-Fos, GFAP, IL-1beta and p-NR1 and attenuate the reduction of PPT induced by ETM.	fluorocitrate	27-40	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-123
32767851-10	2021	Furthermore, we found that fluorocitrate administration at 3 days after ETM could markedly suppress the expression of c-Fos, GFAP, IL-1beta and p-NR1 and attenuate the reduction of PPT induced by ETM.	fluorocitrate	27-40	glial fibrillary acidic protein	Homo sapiens	125-129
32767851-10	2021	Furthermore, we found that fluorocitrate administration at 3 days after ETM could markedly suppress the expression of c-Fos, GFAP, IL-1beta and p-NR1 and attenuate the reduction of PPT induced by ETM.	fluorocitrate	27-40	interleukin 1 alpha	Homo sapiens	131-139
32767851-10	2021	Furthermore, we found that fluorocitrate administration at 3 days after ETM could markedly suppress the expression of c-Fos, GFAP, IL-1beta and p-NR1 and attenuate the reduction of PPT induced by ETM.	fluorocitrate	27-40	NADPH dependent diflavin oxidoreductase 1	Homo sapiens	146-149
31734690-6	2020	Notably, ectopic expression of ACO1 alleviated the susceptibility of cell lines to fluorocitrate and, conversely, knockdown experiments increased susceptibility of resistant cell lines.	fluorocitrate	83-96	aconitase 1	Mus musculus	31-35
30098388-7	2019	However, the Bz-ATP effect in CA1 cells was inhibited by gabazine or the astrocytic toxin fluorocitrate suggesting stimulation of P2X7Rs at stratum radiatum astrocytes located near to interneurons and synapsing onto CA1 neurons.	fluorocitrate	90-103	carbonic anhydrase 1	Mus musculus	30-33
32070010-8	2020	Fluorocitrate administration into the TG significantly reduced the number of GFAP-IR cells and prevented the MHWT reduction in IANX rats.	fluorocitrate	0-13	glial fibrillary acidic protein	Rattus norvegicus	77-81
31270712-0	2019	Inhibition of Reactive Astrocytes with Fluorocitrate Ameliorates Learning and Memory Impairment Through Upregulating CRTC1 and Synaptophysin in Ischemic Stroke Rats.	fluorocitrate	39-52	CREB regulated transcription coactivator 1	Rattus norvegicus	117-122
31270712-0	2019	Inhibition of Reactive Astrocytes with Fluorocitrate Ameliorates Learning and Memory Impairment Through Upregulating CRTC1 and Synaptophysin in Ischemic Stroke Rats.	fluorocitrate	39-52	synaptophysin	Rattus norvegicus	127-140
31270712-10	2019	Taken together, our findings demonstrate that inhibiting reactive astrocytes with fluorocitrate immediately before reperfusion may protect against ischemic stroke-induced memory impairment through the upregulation of CRTC1 and SYP.	fluorocitrate	82-95	CREB regulated transcription coactivator 1	Rattus norvegicus	217-222
31270712-10	2019	Taken together, our findings demonstrate that inhibiting reactive astrocytes with fluorocitrate immediately before reperfusion may protect against ischemic stroke-induced memory impairment through the upregulation of CRTC1 and SYP.	fluorocitrate	82-95	synaptophysin	Rattus norvegicus	227-230
29678774-5	2018	The fluorocitrate (an inhibitor of glial cells) was microinjected into the CA1 area before morphine injection.	fluorocitrate	4-17	carbonic anhydrase 1	Rattus norvegicus	75-78
30955244-11	2019	Moreover, intrathecal administration of rat peptide, CXCL12, induced hypersensitivity in naive rats, which was partly reversed by fluorocitrate.	fluorocitrate	130-143	C-X-C motif chemokine ligand 12	Rattus norvegicus	53-59
31281242-9	2019	Intrathecal administration of IL-1ra (20 ng) on days 0 to 3 post-surgery also facilitated the CCI-induced development of mechanical allodynia, and this early developed pain was dose-dependently attenuated by the administration of the P450c17 inhibitor, ketoconazole (1, 3, or 10 nmol) or the astrocyte metabolic inhibitor, fluorocitrate (0.01, 0.03, or 0.1 nmol).	fluorocitrate	323-336	interleukin 1 receptor antagonist	Mus musculus	30-36
31281242-9	2019	Intrathecal administration of IL-1ra (20 ng) on days 0 to 3 post-surgery also facilitated the CCI-induced development of mechanical allodynia, and this early developed pain was dose-dependently attenuated by the administration of the P450c17 inhibitor, ketoconazole (1, 3, or 10 nmol) or the astrocyte metabolic inhibitor, fluorocitrate (0.01, 0.03, or 0.1 nmol).	fluorocitrate	323-336	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	234-241
29626506-7	2018	To suppress glial cells activity, the animals received microinjection of fluorocitrate (FC, a metabolic inhibitor of glial cells) into the CA1 region before each morphine administration.	fluorocitrate	73-86	carbonic anhydrase 1	Rattus norvegicus	139-142
29678208-13	2018	Moreover, microinjection of fluorocitrate into the TGs completely blocked TMJ inflammation-induced activation of SGCs and the upregulation of IL-1beta and COX-2 in the SGCs, and phospho-CREB and Nav1.7 in the neurons and alleviated inflammation-induced TMJ hypernociception.	fluorocitrate	28-41	interleukin 1 beta	Rattus norvegicus	142-150
29678208-13	2018	Moreover, microinjection of fluorocitrate into the TGs completely blocked TMJ inflammation-induced activation of SGCs and the upregulation of IL-1beta and COX-2 in the SGCs, and phospho-CREB and Nav1.7 in the neurons and alleviated inflammation-induced TMJ hypernociception.	fluorocitrate	28-41	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	155-160
29678208-13	2018	Moreover, microinjection of fluorocitrate into the TGs completely blocked TMJ inflammation-induced activation of SGCs and the upregulation of IL-1beta and COX-2 in the SGCs, and phospho-CREB and Nav1.7 in the neurons and alleviated inflammation-induced TMJ hypernociception.	fluorocitrate	28-41	cAMP responsive element binding protein 1	Rattus norvegicus	186-190
29678208-13	2018	Moreover, microinjection of fluorocitrate into the TGs completely blocked TMJ inflammation-induced activation of SGCs and the upregulation of IL-1beta and COX-2 in the SGCs, and phospho-CREB and Nav1.7 in the neurons and alleviated inflammation-induced TMJ hypernociception.	fluorocitrate	28-41	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	195-201
29311654-7	2018	Western blot and flow cytometry showed that multiple intrathecal administrations of astrocytic inhibitor fluorocitrate decreased IFN-gamma-production without decreasing T cell number in the spinal cord.	fluorocitrate	105-118	interferon gamma	Rattus norvegicus	129-138
29515856-1	2018	The action of fluoroacetate as a broad-spectrum mammalian pesticide depends on the "lethal synthesis" of fluorocitrate by citrate synthase, through a subtle enantioselective enolization of fluoroacetyl-coenzyme A.	fluorocitrate	105-118	citrate synthase	Homo sapiens	122-138
29849572-6	2018	Furthermore, administering fluorocitrate to inhibit astrocyte activation resulted in decreased neurotrophin expression in the spinal ventral horn and delayed axonal regeneration in the nerve as well as motor function recovery.	fluorocitrate	27-40	brain derived neurotrophic factor	Homo sapiens	95-107
25749305-12	2015	pretreatment with fluorocitrate, an astrocyte inhibitor, restored minocycline- or IL-1ra-induced contralateral MA.	fluorocitrate	18-31	interleukin 1 receptor antagonist	Rattus norvegicus	82-88
28615336-9	2017	In contrast, fluorocitrate administrated after the first NGF injection reduced significantly the proportion of neurons with deep input (15.8%, P < 0.01).	fluorocitrate	13-26	nerve growth factor	Rattus norvegicus	57-60
27986591-6	2017	Intrathecal administration of D-serine restored MA as well as the GluN1 phosphorylation on day 3 after surgery that was suppressed by the Sig-1R antagonist, N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide or the astrocyte inhibitor, fluorocitrate.	fluorocitrate	269-282	sigma non-opioid intracellular receptor 1	Mus musculus	138-144
26603138-8	2016	Fluorocitrate, an astrocytic inhibitor, significantly decreased GFAP and nestin expression in ischemic brains, and also reduced VEGF-enhanced neurogenic effects.	fluorocitrate	0-13	glial fibrillary acidic protein	Rattus norvegicus	64-68
26603138-8	2016	Fluorocitrate, an astrocytic inhibitor, significantly decreased GFAP and nestin expression in ischemic brains, and also reduced VEGF-enhanced neurogenic effects.	fluorocitrate	0-13	vascular endothelial growth factor A	Rattus norvegicus	128-132
25635831-9	2015	Furthermore, selective glial inhibitors, minocycline and fluorocitrate, attenuated the hyperalgesia induced by intrathecal CCL5.	fluorocitrate	57-70	C-C motif chemokine ligand 5	Homo sapiens	123-127
25598703-12	2014	CONCLUSIONS: Fluorocitrate can inhibit the activation of glial cells in spinal cord and DRG, and reduce MIP.	fluorocitrate	13-26	major intrinsic protein of lens fiber	Rattus norvegicus	104-107
23776243-9	2013	fluorocitrate blocked fractalkine (i.gl.	fluorocitrate	0-13	C-X3-C motif chemokine ligand 1	Rattus norvegicus	22-33
24886406-9	2014	Spinal treatment (on day 14 after injury) with minocycline (100 mug/day) or fluorocitrate (1 nmol/day) for 7 days reduced tactile allodynia and spinal nerve injury-induced up-regulation in Iba-1 and GFAP, respectively.	fluorocitrate	76-89	allograft inflammatory factor 1	Rattus norvegicus	189-194
24886406-9	2014	Spinal treatment (on day 14 after injury) with minocycline (100 mug/day) or fluorocitrate (1 nmol/day) for 7 days reduced tactile allodynia and spinal nerve injury-induced up-regulation in Iba-1 and GFAP, respectively.	fluorocitrate	76-89	glial fibrillary acidic protein	Rattus norvegicus	199-203
24886406-11	2014	Intrathecal treatment (on day 21 after injury) with the selective P2Y6 (PSB0474, 3-30 muM) and P2Y11 (NF546, 1-10 muM) receptor agonists produced remarkable tactile allodynia in nerve ligated rats previously treated with minocycline or fluorocitrate for 7 days.	fluorocitrate	236-249	pyrimidinergic receptor P2Y6	Rattus norvegicus	66-70
24735601-8	2014	Spinal CXCL12 was predominately expressed in astrocytes, and an intrathecal injection of astrocyte metabolic inhibitor fluorocitrate or selective JNK inhibitor SP600125 abolished TCI-induced CXCL12 production.	fluorocitrate	119-132	C-X-C motif chemokine ligand 12	Rattus norvegicus	7-13
24735601-8	2014	Spinal CXCL12 was predominately expressed in astrocytes, and an intrathecal injection of astrocyte metabolic inhibitor fluorocitrate or selective JNK inhibitor SP600125 abolished TCI-induced CXCL12 production.	fluorocitrate	119-132	C-X-C motif chemokine ligand 12	Rattus norvegicus	191-197
23811556-3	2013	In vitro, a variety of aconitase-inhibitors, such as fluorocitrate, cyanide ion, ferricyanide ([Fe(CN)6]), and various oxidants including superoxide anion, inhibited the activity of m-aconitase even in the presence of Fe(II), whereas a NO-donor, nitroprusside (SNP) ([Fe(CN)5NO]), was the only agent that significantly increased activity of that enzyme.	fluorocitrate	53-66	aconitase 2	Homo sapiens	182-193
22972308-6	2012	Minocycline, fluorocitrate, or SB203580 pretreatment suppressed this IL-1beta-upregulated P-p38 MAPK mainly in microglia and iNOS mainly in astrocytes; minocycline exhibited the most potent effect.	fluorocitrate	13-26	interleukin 1 beta	Rattus norvegicus	69-77
22972308-6	2012	Minocycline, fluorocitrate, or SB203580 pretreatment suppressed this IL-1beta-upregulated P-p38 MAPK mainly in microglia and iNOS mainly in astrocytes; minocycline exhibited the most potent effect.	fluorocitrate	13-26	mitogen activated protein kinase 14	Rattus norvegicus	92-95
22972308-0	2012	Minocycline and fluorocitrate suppress spinal nociceptive signaling in intrathecal IL-1beta-induced thermal hyperalgesic rats.	fluorocitrate	16-29	interleukin 1 beta	Rattus norvegicus	83-91
22972308-6	2012	Minocycline, fluorocitrate, or SB203580 pretreatment suppressed this IL-1beta-upregulated P-p38 MAPK mainly in microglia and iNOS mainly in astrocytes; minocycline exhibited the most potent effect.	fluorocitrate	13-26	nitric oxide synthase 2	Rattus norvegicus	125-129
22972308-7	2012	Minocycline and fluorocitrate pretreatment abrogated IL-1beta-induced NO release and thermal hyperalgesia in rats.	fluorocitrate	16-29	interleukin 1 beta	Rattus norvegicus	53-61
22972308-8	2012	In conclusion, minocycline, fluorocitrate, and SB203580 effectively suppressed the IL-1beta-induced central sensitization and hyperalgesia in rats.	fluorocitrate	28-41	interleukin 1 beta	Rattus norvegicus	83-91
23110394-8	2012	Intracisternal administration of fluorocitrate for 5 days blocked the development of mechanical hyperalgesia as well as the upregulation of GFAP and NR1 in the Sp5C.	fluorocitrate	33-46	glial fibrillary acidic protein	Rattus norvegicus	140-144
23110394-8	2012	Intracisternal administration of fluorocitrate for 5 days blocked the development of mechanical hyperalgesia as well as the upregulation of GFAP and NR1 in the Sp5C.	fluorocitrate	33-46	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	149-152
22044922-5	2011	Additionally, mechanical allodynia and GFAP overexpression was induced by the spinal administration of exogenous BDNF to naive rats, and exogenous BDNF given together with fluorocitrate, an astrocytic metabolism inhibitor, inhibited allodynia and GFAP upregulation.	fluorocitrate	172-185	glial fibrillary acidic protein	Rattus norvegicus	39-43
22001426-9	2012	The fractalkine effect was inhibited by fluorocitrate and anti-TNF-alpha.	fluorocitrate	40-53	C-X3-C motif chemokine ligand 1	Rattus norvegicus	4-15
22044922-5	2011	Additionally, mechanical allodynia and GFAP overexpression was induced by the spinal administration of exogenous BDNF to naive rats, and exogenous BDNF given together with fluorocitrate, an astrocytic metabolism inhibitor, inhibited allodynia and GFAP upregulation.	fluorocitrate	172-185	brain-derived neurotrophic factor	Rattus norvegicus	147-151
22044922-5	2011	Additionally, mechanical allodynia and GFAP overexpression was induced by the spinal administration of exogenous BDNF to naive rats, and exogenous BDNF given together with fluorocitrate, an astrocytic metabolism inhibitor, inhibited allodynia and GFAP upregulation.	fluorocitrate	172-185	glial fibrillary acidic protein	Rattus norvegicus	247-251
20587056-13	2010	The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%.	fluorocitrate	132-145	bradykinin receptor B1	Rattus norvegicus	30-33
21086065-3	2011	Confocal microscopy showed that fluorocitrate pretreatment reduced astrocytic uptake of Alexa568-leptin 30 min after icv while increasing neuronal uptake in the arcuate nucleus and dorsomedial hypothalamus.	fluorocitrate	32-45	leptin	Mus musculus	97-103
21086065-4	2011	Fluorocitrate also induced mild astrogliosis and moderately increased pSTAT3 immunopositive neurons in response to Alexa568-leptin in the dorsomedial hypothalamus.	fluorocitrate	0-13	leptin	Mus musculus	124-130
21086065-6	2011	The results show that fluorocitrate induced a mild pSTAT3 activation but attenuated leptin-induced pSTAT3 activation and decreased GFAP expression independently of leptin treatment.	fluorocitrate	22-35	leptin	Mus musculus	84-90
21086065-6	2011	The results show that fluorocitrate induced a mild pSTAT3 activation but attenuated leptin-induced pSTAT3 activation and decreased GFAP expression independently of leptin treatment.	fluorocitrate	22-35	glial fibrillary acidic protein	Mus musculus	131-135
21162132-8	2011	Inhibiting astrocytes with fluorocitrate (FCA) prevented the response of the SON to HS and attenuated the release of VP, similarly to SDV surgery.	fluorocitrate	27-40	arginine vasopressin	Homo sapiens	117-119
21162132-8	2011	Inhibiting astrocytes with fluorocitrate (FCA) prevented the response of the SON to HS and attenuated the release of VP, similarly to SDV surgery.	fluorocitrate	42-45	arginine vasopressin	Homo sapiens	117-119
20722971-9	2010	Furthermore, L-alpha-aminoadipate, the glial inhibitor fluorocitrate, and a peptide inhibitor of c-Jun N-terminal Kinase all reduced light touch-evoked ERK activation ipsilateral to touch.	fluorocitrate	55-68	mitogen-activated protein kinase 1	Homo sapiens	152-155
21922613-0	2011	"Lethal synthesis" of fluorocitrate by citrate synthase explained through QM/MM modeling.	fluorocitrate	22-35	citrate synthase	Homo sapiens	39-55
20572198-7	2011	However, the antidepressant-like effects of imipramine in the LH paradigm were blocked when fluorocitrate (a reversible inhibitor of astrocyte function) was injected into the dentate gyrus or CA3 region.	fluorocitrate	92-105	carbonic anhydrase 3	Rattus norvegicus	192-195
21722369-10	2011	Phosphorylation of ERK (p-ERK) and the transcription factor cAMP response element-binding protein (p-CREB) increased in the spinal cord of CIBP rats, which was attenuated by intrathecal injection of fluorocitrate or U0126.	fluorocitrate	199-212	Eph receptor B1	Rattus norvegicus	19-22
21722369-10	2011	Phosphorylation of ERK (p-ERK) and the transcription factor cAMP response element-binding protein (p-CREB) increased in the spinal cord of CIBP rats, which was attenuated by intrathecal injection of fluorocitrate or U0126.	fluorocitrate	199-212	Eph receptor B1	Rattus norvegicus	26-29
21722369-10	2011	Phosphorylation of ERK (p-ERK) and the transcription factor cAMP response element-binding protein (p-CREB) increased in the spinal cord of CIBP rats, which was attenuated by intrathecal injection of fluorocitrate or U0126.	fluorocitrate	199-212	cAMP responsive element binding protein 1	Rattus norvegicus	101-105
21392888-7	2011	Fluorocitrate also impeded activation of astrocytes and blocked activation of the superficial MDH neural circuit underlying allodynia, as revealed by study of Fos expression.	fluorocitrate	0-13	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-162
20587056-13	2010	The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%.	fluorocitrate	132-145	interleukin 1 beta	Rattus norvegicus	35-43
20587056-13	2010	The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%.	fluorocitrate	132-145	tumor necrosis factor	Rattus norvegicus	45-54
20587056-13	2010	The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%.	fluorocitrate	132-145	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-61
20587056-13	2010	The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%.	fluorocitrate	132-145	allograft inflammatory factor 1	Rattus norvegicus	67-72
20587056-13	2010	The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%.	fluorocitrate	132-145	bradykinin receptor B1	Rattus norvegicus	166-169
10751570-13	2000	gp120 were blocked by spinal pretreatment with drugs (fluorocitrate and CNI-1493) thought to preferentially disrupt glial function.	fluorocitrate	54-67	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	0-5
19997116-9	2010	Compared with stroke-only controls, FC-treated mice demonstrated a significant decrease in HMGB1-positive reactive astrocytes and neurovascular remodeling, as well as a corresponding worsening of behavioral recovery.	fluorocitrate	36-38	high mobility group box 1	Mus musculus	91-96
17443351-0	2007	Hyperalgesia in response to traumatic occlusion and GFAP expression in rat parabrachial [correction of parabranchial] nucleus: modulation with fluorocitrate.	fluorocitrate	143-156	glial fibrillary acidic protein	Rattus norvegicus	52-56
11306633-8	2001	Intrathecal administration of fluorocitrate (a glial metabolic inhibitor), TNF antagonist, and IL-1 antagonist each blocked gp120-induced increases in spinal IL-1 protein.	fluorocitrate	30-43	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	124-129
11306633-8	2001	Intrathecal administration of fluorocitrate (a glial metabolic inhibitor), TNF antagonist, and IL-1 antagonist each blocked gp120-induced increases in spinal IL-1 protein.	fluorocitrate	30-43	interleukin 1 beta	Homo sapiens	158-162
19938175-4	2010	It was found that interruption of astrocyte metabolism with fluorocitrate significantly reduced Fos protein expression in both astrocytes and neurons, whereas blockage of gap junctions with carbenoxolone clearly reduced Fos protein expression in neurons, but not in astrocytes.	fluorocitrate	60-73	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	96-99
17288493-5	2006	Fluoroacetate combines with coenzyme A (CoA-SH) to form fluoroacetyl CoA, which can substitute for acetyl CoA in the tricarboxylic acid cycle and reacts with citrate synthase to produce fluorocitrate, a metabolite of which then binds very tightly to aconitase, thereby halting the cycle.	fluorocitrate	186-199	citrate synthase	Homo sapiens	158-174
11008218-12	2000	The steady-state level of opsin in retinas exposed to alpha-aminoadipic acid was unchanged compared with control eyes, whereas, in eyes exposed to fluorocitrate, opsin levels were slightly reduced.	fluorocitrate	147-160	rhodopsin, gene2 L homeolog	Xenopus laevis	162-167
9272684-0	1997	Increase of catechol-O-methyltransferase activity in rat brain microglia after intrastriatal infusion of fluorocitrate, a glial toxin.	fluorocitrate	105-118	catechol-O-methyltransferase	Rattus norvegicus	12-40
9272684-3	1997	Three days after fluorocitrate infusion the activity of MAO-B was reduced, whereas COMT and PDE activities were increased.	fluorocitrate	17-30	monoamine oxidase B	Rattus norvegicus	56-61
9272684-3	1997	Three days after fluorocitrate infusion the activity of MAO-B was reduced, whereas COMT and PDE activities were increased.	fluorocitrate	17-30	catechol-O-methyltransferase	Rattus norvegicus	83-87
8836557-7	1996	Fluorocitrate, a suicidal-inhibitor of aconitase, also protected astrocytes, but not neurons, from hypoxia in "pure" culture, presumably by increasing intracellular citrate concentrations through inhibition of the catalysis of citrate to isocitrate We conclude that FBP and citrate attenuate hypoxic neuronal injury through their effects on astrocytes.	fluorocitrate	0-13	fructose-bisphosphatase 1	Homo sapiens	266-269
9264033-2	1997	In the present study, the level of NGF mRNA in the hippocampal formation was examined following an intrahippocampal injection of 1 nmole fluorocitrate, which temporarily inhibits the astrocyte metabolic activity in vivo.	fluorocitrate	137-150	nerve growth factor	Rattus norvegicus	35-38
8891289-2	1996	In the slice treated with fluorocitrate (100 microM), a glia-specific metabolic inhibitor, 10 min AA induced hyperexcitation as evidenced by an appearance of multiple population spikes evoked by stimulation of the Schaffer collateral/commissural pathway in the CA1 region prior to elimination of the response.	fluorocitrate	26-39	carbonic anhydrase 1	Rattus norvegicus	261-264
7532831-4	1994	administration of fluorocitrate (1 nmol) results in a marked, but reversible, attenuation of the persistent thermal and mechanical hyperalgesia produced by intraplantar zymosan (5 mg); (2) selective inhibition of the inducible form of nitric oxide synthase (iNOS) with i.t.	fluorocitrate	18-31	nitric oxide synthase 2	Rattus norvegicus	258-262
7644703-7	1995	Fluorocitrate totally blocked the ANP-evoked cGMP responses in brain slices.	fluorocitrate	0-13	natriuretic peptide A	Rattus norvegicus	34-37
7644703-9	1995	Likewise, the cGMP response induced by CNP was only partially affected by fluorocitrate.	fluorocitrate	74-87	natriuretic peptide C	Rattus norvegicus	39-42
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	glial fibrillary acidic protein	Mus musculus	146-150
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	S100 protein, beta polypeptide, neural	Mus musculus	152-157
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	allograft inflammatory factor 1	Mus musculus	159-164
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	integrin alpha M	Mus musculus	166-171
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	tumor necrosis factor	Mus musculus	173-182
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	interleukin 6	Mus musculus	184-188
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	nitric oxide synthase 2, inducible	Mus musculus	190-194
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	vascular cell adhesion molecule 1	Mus musculus	196-202
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	intercellular adhesion molecule 1	Mus musculus	204-210
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	matrix metallopeptidase 9	Mus musculus	212-217
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	occludin	Mus musculus	219-227
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	claudin 5	Mus musculus	233-242