PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20097954-2	2009	Recently, novel carboxymethylated pyridoindoles, structural analogues of the efficient chain-breaking antioxidant stobadine, were designed, synthesised and characterised as prospective aldose reductase inhibitors endowed with antioxidant activity.	dicarbine	114-123	aldo-keto reductase family 1 member B1	Rattus norvegicus	185-201
27597816-1	2016	HIGHLIGHTS Compounds that interact with multiple targets but minimally with the cytochrome P450 system (CYP) address the many factors leading to neurodegeneration.Acetyl- and Butyryl-cholineEsterases (AChE, BChE) and Monoamine Oxidases A/B (MAO A, MAO B) are targets for Multi-Target Designed Ligands (MTDL).ASS234 is an irreversible inhibitor of MAO A >MAO B and has micromolar potency against the cholinesterases.ASS234 is a poor CYP substrate in human liver, yielding the depropargylated metabolite.SMe1EC2, a stobadine derivative, showed high radical scavenging property, in vitro and in vivo giving protection in head trauma and diabetic damage of endothelium.Control of mitochondrial function and morphology by manipulating fission and fusion is emerging as a target area for therapeutic strategies to decrease the pathological outcome of neurodegenerative diseases.	dicarbine	516-525	acetylcholinesterase (Cartwright blood group)	Homo sapiens	201-205
27597816-1	2016	HIGHLIGHTS Compounds that interact with multiple targets but minimally with the cytochrome P450 system (CYP) address the many factors leading to neurodegeneration.Acetyl- and Butyryl-cholineEsterases (AChE, BChE) and Monoamine Oxidases A/B (MAO A, MAO B) are targets for Multi-Target Designed Ligands (MTDL).ASS234 is an irreversible inhibitor of MAO A >MAO B and has micromolar potency against the cholinesterases.ASS234 is a poor CYP substrate in human liver, yielding the depropargylated metabolite.SMe1EC2, a stobadine derivative, showed high radical scavenging property, in vitro and in vivo giving protection in head trauma and diabetic damage of endothelium.Control of mitochondrial function and morphology by manipulating fission and fusion is emerging as a target area for therapeutic strategies to decrease the pathological outcome of neurodegenerative diseases.	dicarbine	516-525	butyrylcholinesterase	Homo sapiens	207-211
20066176-1	2010	Recently novel carboxymethylated pyridoindoles, analogues of the efficient chain-breaking antioxidant stobadine, have been designed, synthesised and characterised as bifunctional compounds with joint antioxidant/aldose reductase inhibitory activities with the potential of preventing diabetic complications.	dicarbine	102-111	aldo-keto reductase family 1 member B1	Rattus norvegicus	212-228
27597816-1	2016	HIGHLIGHTS Compounds that interact with multiple targets but minimally with the cytochrome P450 system (CYP) address the many factors leading to neurodegeneration.Acetyl- and Butyryl-cholineEsterases (AChE, BChE) and Monoamine Oxidases A/B (MAO A, MAO B) are targets for Multi-Target Designed Ligands (MTDL).ASS234 is an irreversible inhibitor of MAO A >MAO B and has micromolar potency against the cholinesterases.ASS234 is a poor CYP substrate in human liver, yielding the depropargylated metabolite.SMe1EC2, a stobadine derivative, showed high radical scavenging property, in vitro and in vivo giving protection in head trauma and diabetic damage of endothelium.Control of mitochondrial function and morphology by manipulating fission and fusion is emerging as a target area for therapeutic strategies to decrease the pathological outcome of neurodegenerative diseases.	dicarbine	516-525	monoamine oxidase A	Homo sapiens	217-239
27597816-1	2016	HIGHLIGHTS Compounds that interact with multiple targets but minimally with the cytochrome P450 system (CYP) address the many factors leading to neurodegeneration.Acetyl- and Butyryl-cholineEsterases (AChE, BChE) and Monoamine Oxidases A/B (MAO A, MAO B) are targets for Multi-Target Designed Ligands (MTDL).ASS234 is an irreversible inhibitor of MAO A >MAO B and has micromolar potency against the cholinesterases.ASS234 is a poor CYP substrate in human liver, yielding the depropargylated metabolite.SMe1EC2, a stobadine derivative, showed high radical scavenging property, in vitro and in vivo giving protection in head trauma and diabetic damage of endothelium.Control of mitochondrial function and morphology by manipulating fission and fusion is emerging as a target area for therapeutic strategies to decrease the pathological outcome of neurodegenerative diseases.	dicarbine	516-525	monoamine oxidase A	Homo sapiens	241-246
27597816-1	2016	HIGHLIGHTS Compounds that interact with multiple targets but minimally with the cytochrome P450 system (CYP) address the many factors leading to neurodegeneration.Acetyl- and Butyryl-cholineEsterases (AChE, BChE) and Monoamine Oxidases A/B (MAO A, MAO B) are targets for Multi-Target Designed Ligands (MTDL).ASS234 is an irreversible inhibitor of MAO A >MAO B and has micromolar potency against the cholinesterases.ASS234 is a poor CYP substrate in human liver, yielding the depropargylated metabolite.SMe1EC2, a stobadine derivative, showed high radical scavenging property, in vitro and in vivo giving protection in head trauma and diabetic damage of endothelium.Control of mitochondrial function and morphology by manipulating fission and fusion is emerging as a target area for therapeutic strategies to decrease the pathological outcome of neurodegenerative diseases.	dicarbine	516-525	monoamine oxidase B	Homo sapiens	248-253
27597816-1	2016	HIGHLIGHTS Compounds that interact with multiple targets but minimally with the cytochrome P450 system (CYP) address the many factors leading to neurodegeneration.Acetyl- and Butyryl-cholineEsterases (AChE, BChE) and Monoamine Oxidases A/B (MAO A, MAO B) are targets for Multi-Target Designed Ligands (MTDL).ASS234 is an irreversible inhibitor of MAO A >MAO B and has micromolar potency against the cholinesterases.ASS234 is a poor CYP substrate in human liver, yielding the depropargylated metabolite.SMe1EC2, a stobadine derivative, showed high radical scavenging property, in vitro and in vivo giving protection in head trauma and diabetic damage of endothelium.Control of mitochondrial function and morphology by manipulating fission and fusion is emerging as a target area for therapeutic strategies to decrease the pathological outcome of neurodegenerative diseases.	dicarbine	516-525	monoamine oxidase A	Homo sapiens	347-352
27597816-1	2016	HIGHLIGHTS Compounds that interact with multiple targets but minimally with the cytochrome P450 system (CYP) address the many factors leading to neurodegeneration.Acetyl- and Butyryl-cholineEsterases (AChE, BChE) and Monoamine Oxidases A/B (MAO A, MAO B) are targets for Multi-Target Designed Ligands (MTDL).ASS234 is an irreversible inhibitor of MAO A >MAO B and has micromolar potency against the cholinesterases.ASS234 is a poor CYP substrate in human liver, yielding the depropargylated metabolite.SMe1EC2, a stobadine derivative, showed high radical scavenging property, in vitro and in vivo giving protection in head trauma and diabetic damage of endothelium.Control of mitochondrial function and morphology by manipulating fission and fusion is emerging as a target area for therapeutic strategies to decrease the pathological outcome of neurodegenerative diseases.	dicarbine	516-525	monoamine oxidase B	Homo sapiens	357-362
18383921-5	2008	The effects of stobadine, theophylline and adenine derivatives on the activity of caspase 1 was investigated with the use of spectrophotometry.	dicarbine	15-24	caspase 1	Homo sapiens	82-91
18395454-1	2008	Starting from the efficient hexahydropyridoindole antioxidant stobadine, a series of carboxymethylated tetrahydro- and hexahydropyridoindole derivatives was synthesized and tested for the inhibition of aldose reductase, an enzyme involved in the etiology of diabetic complications.	dicarbine	62-71	aldo-keto reductase family 1 member B1	Rattus norvegicus	202-218
12718433-2	2003	In the brain, although 6-phosphogluconate dehydrogenase activity (6-PGD) did not change, glucose-6-phosphate dehydrogenase activity (G-6PD) was markedly increased in diabetic rats compared with controls; only combined treatment with ST and vitamin E produced a partial prevention on this alteration.	dicarbine	233-235	glucose-6-phosphate dehydrogenase	Rattus norvegicus	89-122
17481927-0	2007	Stobadine inhibits doxorubicin-induced apoptosis through a caspase-9 dependent pathway in P815 mastocytoma cells.	dicarbine	0-9	caspase 9	Mus musculus	59-68
17481927-4	2007	In the present study we investigated the effects of stobadine, a pyridoindole antioxidant in a DOXO-induced apoptosis model of P815 cells by flow cytometric analyses and by measuring caspase-3 and caspase-9 activities.	dicarbine	52-61	caspase 3	Mus musculus	183-192
17481927-4	2007	In the present study we investigated the effects of stobadine, a pyridoindole antioxidant in a DOXO-induced apoptosis model of P815 cells by flow cytometric analyses and by measuring caspase-3 and caspase-9 activities.	dicarbine	52-61	caspase 9	Mus musculus	197-206
17481927-7	2007	The antiapoptotic effect of stobadine was further confirmed by inhibition of caspase-3 and caspase-9 activities.	dicarbine	28-37	caspase 3	Mus musculus	77-86
17481927-7	2007	The antiapoptotic effect of stobadine was further confirmed by inhibition of caspase-3 and caspase-9 activities.	dicarbine	28-37	caspase 9	Mus musculus	91-100
12849078-0	2003	Pyridoindole antioxidant stobadine protected bovine serum albumin against the hydroxyl radical mediated cross-linking in vitro.	dicarbine	25-34	albumin	Homo sapiens	52-65
17250641-16	2007	In addition, the decreased G-6PD activity observed after I/R was significantly attenuated by stobadine treatment.	dicarbine	93-102	glucose-6-phosphate dehydrogenase	Rattus norvegicus	27-32
17250641-19	2007	In addition, stobadine decreased the morphological deterioration and high P-selectin immunoreactivity secondary to renal I/R injury.	dicarbine	13-22	selectin P	Rattus norvegicus	74-84
16871535-0	2007	Inhibitory effect of stobadine on FMLP-induced chemiluminescence in human whole blood and isolated polymorphonuclear leukocytes.	dicarbine	21-30	formyl peptide receptor 1	Homo sapiens	34-38
16871535-2	2007	In whole blood and in isolated PMNL, stobadine in the concentrations of 1, 10 and 100 micromol/L significantly inhibited the CL signal after FMLP, which activated predominantly extracellular generation of ROM.	dicarbine	37-46	formyl peptide receptor 1	Homo sapiens	141-145
16871535-4	2007	On the other hand, myeloperoxidase (MPO) liberation was decreased by stobadine only in the concentration of 100 micromol/L.	dicarbine	69-78	myeloperoxidase	Homo sapiens	19-34
16871535-4	2007	On the other hand, myeloperoxidase (MPO) liberation was decreased by stobadine only in the concentration of 100 micromol/L.	dicarbine	69-78	myeloperoxidase	Homo sapiens	36-39
16871535-5	2007	The results showed stobadine to act as a potent inhibitor/scavenger of extracellularly produced ROM in human PMNL and indicated interference of stobadine with ROM as well as with signalling events resulting in NADPH-oxidase activation and MPO liberation.	dicarbine	19-28	myeloperoxidase	Homo sapiens	239-242
16871535-5	2007	The results showed stobadine to act as a potent inhibitor/scavenger of extracellularly produced ROM in human PMNL and indicated interference of stobadine with ROM as well as with signalling events resulting in NADPH-oxidase activation and MPO liberation.	dicarbine	144-153	myeloperoxidase	Homo sapiens	239-242
15349134-4	2004	Stobadine dose-dependently decreased superoxide generation and myeloperoxidase release after receptor-specific stimuli, with the highest effect on fMLP stimulation of superoxide generation and on opsonized zymosan stimulation of myeloperoxidase release.	dicarbine	0-9	formyl peptide receptor 1	Homo sapiens	147-151
12718433-13	2003	Diabetes-induced abnormalities in CAT activity did not respond to vitamin E alone in heart, was moderately ameliorated by the treatment with this vitamin in kidney, and was completely prevented by ST alone in both tissues.	dicarbine	197-199	catalase	Rattus norvegicus	34-37
12718433-7	2003	Diabetes-induced stimulation in GSHPx did not decrease in response to the treatment with vitamin E in heart and kidney, but was greatly prevented by ST alone.	dicarbine	149-151	glutathione peroxidase 1	Rattus norvegicus	32-37
10629755-3	1999	The amplitude of population spikes (PoS) evoked trans-synaptically by electrical stimulation of Schaffer collaterals and recorded in CA1 neurons was the parameter of ST. Pretreatment of slices with stobadine dissolved in slice superfusion media (1 to 100 microM) improved ST recovery after 20-min tissue ROX.	dicarbine	198-207	carbonic anhydrase 1	Rattus norvegicus	133-136
9626593-2	1998	The present study examined the ability of stobadine to protect erythrocyte membrane against free radical injury after long-term carbon tetrachloride (CCl4) application.	dicarbine	42-51	C-C motif chemokine ligand 4	Rattus norvegicus	150-154
10576437-2	1999	Stobadine administered locally into the colon was found to reduce the extent of colonic mucosal injury, abolish the increase in myeloperoxidase activity, attenuate the enhanced vascular permeability, and prevent the depletion of reduced glutathione.	dicarbine	0-9	myeloperoxidase	Homo sapiens	128-143
10576441-3	1999	Serum enzyme activities of AST, CPK and LDH after stobadine application were significantly decreased.	dicarbine	50-59	solute carrier family 17 member 5	Homo sapiens	27-30
10576441-3	1999	Serum enzyme activities of AST, CPK and LDH after stobadine application were significantly decreased.	dicarbine	50-59	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	32-35
10576442-0	1999	Stobadine is a potent modulator of endogenous endothelin-1 in human fibroblasts.	dicarbine	0-9	endothelin 1	Homo sapiens	46-58
10576442-5	1999	Our results indicate that stobadine significantly potentiated ET-1 binding by reductive ET(B) selective degradation of ET-1 in HF.	dicarbine	26-35	endothelin receptor type B	Homo sapiens	88-93
10576442-6	1999	Hence, it is very plausible that stobadine may modulate endogenous endothelin and its intracellular mitogenic and chemotactic factors, principally by affecting two presumably related processes, participating in the proliferative and mitogenic response, (1) potentiation of signal trasduction from ET(A) receptors, and (2) subtype-ET(B) selective intracellular processing.	dicarbine	33-42	endothelin receptor type B	Homo sapiens	330-335
10576453-1	1999	Under conditions of an experimental in vitro glycation model, the pyridoindole antioxidant stobadine significantly inhibited glycation-related fluorescence changes of bovine serum albumin as well as the yield of 2,4-dinitrophenylhydrazine-reactive carbonyls with an efficacy comparable to that of the reference antioxidants Trolox C and 2-keto-4-methiolbutyric acid, and more efficiently than did aminoguanidine.	dicarbine	91-100	albumin	Homo sapiens	180-187
9626593-9	1998	Based on these results, it can be concluded that protective effect of stobadine on CCl4-induced erythrocyte membrane changes should be related to its antioxidant properties.	dicarbine	70-79	C-C motif chemokine ligand 4	Rattus norvegicus	83-87
9626593-6	1998	Stobadine in both doses (10.0 and 20.0 mg.kg-1) protected erythrocyte membrane against CCl4-induced injury.	dicarbine	0-9	C-C motif chemokine ligand 4	Rattus norvegicus	87-91
9626593-8	1998	In presence of stobadine, CCl4-induced lipid peroxidation was partially or totally prevented whereas the level of total membrane thiols was increased.	dicarbine	15-24	C-C motif chemokine ligand 4	Rattus norvegicus	26-30
8241252-9	1993	Both butylated hydroxytoluene and stobadine prevented the formation of TBARS and were partially effective in protecting the Ca-pump ATPase from tBHP-induced inhibition.	dicarbine	34-43	dynein axonemal heavy chain 8	Homo sapiens	132-138
9357020-5	1997	Stobadine, a pyridoindole derivative, prevented the decrease in membrane fluidity and in Na+/Ca2+ exchanger activity.	dicarbine	0-9	solute carrier family 8 member A1	Homo sapiens	89-107
8777283-1	1996	We studied the effect of the pyridoindole antioxidant stobadine on glycation-induced absorbance and fluorescence changes in bovine serum albumin (BSA), used as a model protein.	dicarbine	54-63	albumin	Homo sapiens	131-144
7612050-1	1995	A 26-week oral toxicity and micronucleus assays of the new cardioprotective drug stobadine (CAS 95751-51-2), in the form of dipalmitate salt (DP 1031) were performed in Wistar rats of both sexes.	dicarbine	81-90	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	92-95
8241252-15	1993	These results may be interpreted to suggest that inhibition of the Ca-pump ATPase in intact RBCs occurs as a result of tBHP-induced oxidant stress and subsequent lipid peroxidation which can be prevented by certain antioxidants including butylated hydroxytoluene, stobadine, and thiol-containing compounds such as dithiothreitol.	dicarbine	264-273	dynein axonemal heavy chain 8	Homo sapiens	75-81
1840475-3	1991	Moreover, stobadine also attenuated the increase in the content of malondialdehyde and activities of catalase and glutathione reductase as well as a diminution in the GSH/GSSG ratio observed in heart mitochondria isolated from ISO-treated animals.	dicarbine	10-19	catalase	Rattus norvegicus	101-109
1438018-3	1992	The peroxidation-related degradation of microsomal cytochrome P-450 was prevented by stobadine in the same pattern.	dicarbine	85-94	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	51-67
1504258-7	1992	The redox potential of stobadine at pH 7 is 0.58 V/NHE.	dicarbine	23-32	solute carrier family 9 member C1	Homo sapiens	51-54
2172269-1	1990	Polar interactions between basic drugs (pentacaine, propranolol, and stobadin) and C18 silanized silica are studied along with hydrophobic interactions by using elution profiles of the drugs obtained with six organic solvents.	dicarbine	69-77	Bardet-Biedl syndrome 9	Homo sapiens	83-86
1840475-3	1991	Moreover, stobadine also attenuated the increase in the content of malondialdehyde and activities of catalase and glutathione reductase as well as a diminution in the GSH/GSSG ratio observed in heart mitochondria isolated from ISO-treated animals.	dicarbine	10-19	glutathione-disulfide reductase	Rattus norvegicus	114-135
177124-1	1975	Methods of physiological analysis were applied to a study of the effect of an original psychotropic agent--carbidine--on the process of adrenergic neurotransmission on a model of an isolated rat Vas deferens.	dicarbine	107-116	arginine vasopressin	Rattus norvegicus	195-198