PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 30844387-7 2019 We found that SMMC-7721 underwent EMT and acquired stemness after co-culture with M2-TAMs, and resulted in larger tumor size following subcutaneous injection of SMMC-7721 suspended in M2-TAMs supernatants compared with SMMC-7721 alone. smmc 14-18 IL2 inducible T cell kinase Homo sapiens 34-37 31415486-3 2019 The human umbilical vein endothelial cell line HUVEC was co-cultured with SDF-1-induced SMMC-7721, and the expressions of CXCR7, CXCR4, and PI3K/Akt pathways after PL treatment were detected by RT-PCR and Western blot analysis. smmc 88-92 C-X-C motif chemokine ligand 12 Homo sapiens 74-79 31251971-7 2019 Furthermore, we found that PCB118 activated NADPH oxidase through the aryl hydrocarbon receptor (AhR) in SMMC-7721 cells. smmc 105-109 aryl hydrocarbon receptor Homo sapiens 70-95 31251971-7 2019 Furthermore, we found that PCB118 activated NADPH oxidase through the aryl hydrocarbon receptor (AhR) in SMMC-7721 cells. smmc 105-109 aryl hydrocarbon receptor Homo sapiens 97-100 30844387-7 2019 We found that SMMC-7721 underwent EMT and acquired stemness after co-culture with M2-TAMs, and resulted in larger tumor size following subcutaneous injection of SMMC-7721 suspended in M2-TAMs supernatants compared with SMMC-7721 alone. smmc 14-18 cholinergic receptor, muscarinic 2, cardiac Mus musculus 82-89 30844387-7 2019 We found that SMMC-7721 underwent EMT and acquired stemness after co-culture with M2-TAMs, and resulted in larger tumor size following subcutaneous injection of SMMC-7721 suspended in M2-TAMs supernatants compared with SMMC-7721 alone. smmc 14-18 cholinergic receptor, muscarinic 2, cardiac Mus musculus 184-191 30844387-7 2019 We found that SMMC-7721 underwent EMT and acquired stemness after co-culture with M2-TAMs, and resulted in larger tumor size following subcutaneous injection of SMMC-7721 suspended in M2-TAMs supernatants compared with SMMC-7721 alone. smmc 161-165 cholinergic receptor, muscarinic 2, cardiac Mus musculus 184-191 30844387-7 2019 We found that SMMC-7721 underwent EMT and acquired stemness after co-culture with M2-TAMs, and resulted in larger tumor size following subcutaneous injection of SMMC-7721 suspended in M2-TAMs supernatants compared with SMMC-7721 alone. smmc 161-165 cholinergic receptor, muscarinic 2, cardiac Mus musculus 184-191 30760494-3 2019 Our study revealed that IBT can inhibit SMMC-7721 cells through irreversible inhibition of mammalian thioredoxin reductase enzymes. smmc 40-44 peroxiredoxin 5 Homo sapiens 101-122 31068299-7 2019 Compared with the cells cultured alone, the co-cultured SMMC-7721 cells showed significantly reduced apoptosis rate in response to sorafenib (P &lt; 0.01) and significantly increased expression of Bcl-2 and Bcl-2/Bax ratio (P &lt; 0.05) with also increased LC3-II/LC3-I ratio (P &lt; 0.001) and lowered expression of p62 (P &lt; 0.05), suggesting a significantly enhanced level of autophagy. smmc 56-60 BCL2 apoptosis regulator Homo sapiens 201-206 31002127-12 2019 SNHG1 knockdown inhibited the proliferative and invasive abilities, and arrested the cell cycle in the G0/G1 phase of SMMC-7721 and SK-HEP-1 cells. smmc 118-122 small nucleolar RNA host gene 1 Homo sapiens 0-5 31068299-7 2019 Compared with the cells cultured alone, the co-cultured SMMC-7721 cells showed significantly reduced apoptosis rate in response to sorafenib (P &lt; 0.01) and significantly increased expression of Bcl-2 and Bcl-2/Bax ratio (P &lt; 0.05) with also increased LC3-II/LC3-I ratio (P &lt; 0.001) and lowered expression of p62 (P &lt; 0.05), suggesting a significantly enhanced level of autophagy. smmc 56-60 BCL2 apoptosis regulator Homo sapiens 211-216 31068299-7 2019 Compared with the cells cultured alone, the co-cultured SMMC-7721 cells showed significantly reduced apoptosis rate in response to sorafenib (P &lt; 0.01) and significantly increased expression of Bcl-2 and Bcl-2/Bax ratio (P &lt; 0.05) with also increased LC3-II/LC3-I ratio (P &lt; 0.001) and lowered expression of p62 (P &lt; 0.05), suggesting a significantly enhanced level of autophagy. smmc 56-60 BCL2 associated X, apoptosis regulator Homo sapiens 217-220 31068299-7 2019 Compared with the cells cultured alone, the co-cultured SMMC-7721 cells showed significantly reduced apoptosis rate in response to sorafenib (P &lt; 0.01) and significantly increased expression of Bcl-2 and Bcl-2/Bax ratio (P &lt; 0.05) with also increased LC3-II/LC3-I ratio (P &lt; 0.001) and lowered expression of p62 (P &lt; 0.05), suggesting a significantly enhanced level of autophagy. smmc 56-60 nucleoporin 62 Homo sapiens 329-332 30630006-7 2019 Furthermore, silencing of endogenous PES1 significantly inhibited the proliferation and tumorigenicity of SMMC 7721 and HepG2 cells in vitro as well as in vivo in nude mice. smmc 106-110 pescadillo ribosomal biogenesis factor 1 Homo sapiens 37-41 30219064-8 2018 Meanwhile, the metastasis of SMMC-7721 cells was also suppressed by LMO3 knockdown in vivo. smmc 29-33 LIM domain only 3 Homo sapiens 68-72 30226584-7 2018 The HIF-1alpha knockout in SMMC-7721 cells significantly suppressed cell invasiveness and migration, and induced cell apoptosis under CoCl2-mimicking hypoxic conditions. smmc 27-31 hypoxia inducible factor 1 subunit alpha Homo sapiens 4-14 29735451-6 2018 The proliferation rate of the cells was positively correlated with the expression levels of p-ERK and topoisomerase IIalpha, which were the lowest in SMMC-7721 cells and the highest in SK-HEP1 cells. smmc 150-154 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 92-97 29793091-6 2018 As expected, the As2O3@PLGA-PEG/LA NPs showed a moderate release rate, the highest anticancer effects and cellular internalization against SMMC-7721 cell line. smmc 139-143 progestagen associated endometrial protein Homo sapiens 28-31 30119680-5 2018 RESULTS: The quantitative analysis indicated that KRAL and Keap1 were significantly decreased and that Nrf2 was increased in HepG2/5-FU and SMMC-7721/5-FU cells compared with the corresponding expression levels in the respective parental cells. smmc 140-144 NFE2 like bZIP transcription factor 2 Homo sapiens 103-107 30119680-6 2018 Overexpression of KRAL increased Keap1 expression, and inactivating the Nrf2-dependent antioxidant pathway could reverse the resistance of HepG2/5-FU and SMMC-7721/5-FU cells to 5-FU. smmc 154-158 NFE2 like bZIP transcription factor 2 Homo sapiens 72-76 29864952-11 2018 Ectopic overexpression of miR-300 reversed TGF-beta1-induced EMT in SMMC-7721 cells, and according to a dual-luciferase reporter assay and rescue assay, miR-300 inhibits the EMT-mediated migration and invasion of HCC cells via the targeted modulation of FAK and the downstream PI3K/AKT signaling pathway. smmc 68-72 microRNA 300 Homo sapiens 26-33 29864952-11 2018 Ectopic overexpression of miR-300 reversed TGF-beta1-induced EMT in SMMC-7721 cells, and according to a dual-luciferase reporter assay and rescue assay, miR-300 inhibits the EMT-mediated migration and invasion of HCC cells via the targeted modulation of FAK and the downstream PI3K/AKT signaling pathway. smmc 68-72 transforming growth factor beta 1 Homo sapiens 43-52 29864952-11 2018 Ectopic overexpression of miR-300 reversed TGF-beta1-induced EMT in SMMC-7721 cells, and according to a dual-luciferase reporter assay and rescue assay, miR-300 inhibits the EMT-mediated migration and invasion of HCC cells via the targeted modulation of FAK and the downstream PI3K/AKT signaling pathway. smmc 68-72 microRNA 300 Homo sapiens 153-160 29864952-11 2018 Ectopic overexpression of miR-300 reversed TGF-beta1-induced EMT in SMMC-7721 cells, and according to a dual-luciferase reporter assay and rescue assay, miR-300 inhibits the EMT-mediated migration and invasion of HCC cells via the targeted modulation of FAK and the downstream PI3K/AKT signaling pathway. smmc 68-72 protein tyrosine kinase 2 Homo sapiens 254-257 29864952-11 2018 Ectopic overexpression of miR-300 reversed TGF-beta1-induced EMT in SMMC-7721 cells, and according to a dual-luciferase reporter assay and rescue assay, miR-300 inhibits the EMT-mediated migration and invasion of HCC cells via the targeted modulation of FAK and the downstream PI3K/AKT signaling pathway. smmc 68-72 AKT serine/threonine kinase 1 Homo sapiens 282-285 29651531-10 2018 Graphical abstract A systemic metabolic alteration induced by glaucocalyxin A (GLA) treatment of SMMC-7721 cells. smmc 97-101 galactosidase alpha Homo sapiens 62-77 29651531-10 2018 Graphical abstract A systemic metabolic alteration induced by glaucocalyxin A (GLA) treatment of SMMC-7721 cells. smmc 97-101 galactosidase alpha Homo sapiens 79-82 29436591-9 2018 The downregulation of sCLU by CLU shRNA synergistically increased SOR sensitivity in the Bel-7402 and SMMC-7721 cells, and potentiated SOR-induced cell apoptosis. smmc 102-106 clusterin Homo sapiens 23-26 29558736-5 2018 Absolute P-gp expression was determined in the human tumor cells MCF-7, HepG-2, and SMMC-7721 and their corresponding drug-resistant subclones MCF-7/ADMs, MCF-7/MXs, MCF-7/MTXs, HepG-2/ADMs, HepG-2/MXs, HepG-2/MTXs, SMMC-7721/ADMs, SMMC-7721/MXs and SMMC-7721/MTXs. smmc 84-88 ATP binding cassette subfamily B member 1 Homo sapiens 9-13 29558736-5 2018 Absolute P-gp expression was determined in the human tumor cells MCF-7, HepG-2, and SMMC-7721 and their corresponding drug-resistant subclones MCF-7/ADMs, MCF-7/MXs, MCF-7/MTXs, HepG-2/ADMs, HepG-2/MXs, HepG-2/MTXs, SMMC-7721/ADMs, SMMC-7721/MXs and SMMC-7721/MTXs. smmc 216-220 ATP binding cassette subfamily B member 1 Homo sapiens 9-13 29558736-5 2018 Absolute P-gp expression was determined in the human tumor cells MCF-7, HepG-2, and SMMC-7721 and their corresponding drug-resistant subclones MCF-7/ADMs, MCF-7/MXs, MCF-7/MTXs, HepG-2/ADMs, HepG-2/MXs, HepG-2/MTXs, SMMC-7721/ADMs, SMMC-7721/MXs and SMMC-7721/MTXs. smmc 216-220 ATP binding cassette subfamily B member 1 Homo sapiens 9-13 29558736-5 2018 Absolute P-gp expression was determined in the human tumor cells MCF-7, HepG-2, and SMMC-7721 and their corresponding drug-resistant subclones MCF-7/ADMs, MCF-7/MXs, MCF-7/MTXs, HepG-2/ADMs, HepG-2/MXs, HepG-2/MTXs, SMMC-7721/ADMs, SMMC-7721/MXs and SMMC-7721/MTXs. smmc 216-220 ATP binding cassette subfamily B member 1 Homo sapiens 9-13 29906128-9 2018 Overexpression of miR-203 in HepG2 and Smmc-7721 cells increases their sensitivity to ionizing radiation in vitro and in vivo. smmc 39-43 microRNA 203a Homo sapiens 18-25 29800916-3 2018 In vitro, ABL-2 not only significantly inhibited the growth of SMMC-7721 cells, but also remarkably blocked the cells" cycle in G2/M phase, inducing DNA damage and eventually leading to apoptosis. smmc 63-67 ABL proto-oncogene 2, non-receptor tyrosine kinase Homo sapiens 10-15 29901200-0 2018 miR-23b inhibits proliferation of SMMC-7721 cells by directly targeting IL-11. smmc 34-38 microRNA 23b Homo sapiens 0-7 29901200-0 2018 miR-23b inhibits proliferation of SMMC-7721 cells by directly targeting IL-11. smmc 34-38 interleukin 11 Homo sapiens 72-77 28910823-8 2017 Camptothecin markedly suppressed NRF2 expression and transcriptional activity in different types of cancer cells including HepG2, SMMC-7721 and A549. smmc 130-134 NFE2 like bZIP transcription factor 2 Homo sapiens 33-37 29467861-10 2018 The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells. smmc 291-295 BCL2 associated X, apoptosis regulator Homo sapiens 80-83 29467861-10 2018 The antiapoptotic-protein Bcl-2 was downregulated, and the proapoptotic protein Bax was upregulated following treatment with the oleanolic acid derivative for 48 h. The oleanolic acid derivative induced the cleavage of caspase-9 and caspase-3 as well as promoted annexin V-FITC/PI uptake in SMMC-7721 cells. smmc 291-295 caspase 9 Homo sapiens 219-228 29467861-11 2018 Furthermore, treatment of SMMC-7721 cells with the oleanolic acid derivative induced a reduction of the intracellular ATP expression level, loss of DeltaPsim and Cyt-C release from the mitochondria. smmc 26-30 cytochrome c, somatic Homo sapiens 162-167 29467900-7 2018 After knocking down RHEB in SMMC-7721 cells, the growth of liver cancer cells was significantly reduced. smmc 28-32 Ras homolog, mTORC1 binding Homo sapiens 20-24 29466986-7 2018 After silencing KIF18A in SMMC-7721 and HepG2 cells, cell growth was obviously inhibited; the migration and invasion abilities were significantly decreased and the in vivo tumour weight was decreased compared to the control group (0.201 +- 0.088 g vs 0.476 +- 0.126 g, p = 0.009). smmc 26-30 kinesin family member 18A Homo sapiens 16-22 29545874-6 2018 Treatment with GDF11 reduced the viability of HepG2 for up to 72 h and GDF11 treatment reduced the viability of SMMC-7721 after 48 and 72 h. Furthermore, GDF11 activated Smad2/3 signaling in HepG2 cells. smmc 112-116 growth differentiation factor 11 Homo sapiens 71-76 29545874-6 2018 Treatment with GDF11 reduced the viability of HepG2 for up to 72 h and GDF11 treatment reduced the viability of SMMC-7721 after 48 and 72 h. Furthermore, GDF11 activated Smad2/3 signaling in HepG2 cells. smmc 112-116 growth differentiation factor 11 Homo sapiens 71-76 29545874-6 2018 Treatment with GDF11 reduced the viability of HepG2 for up to 72 h and GDF11 treatment reduced the viability of SMMC-7721 after 48 and 72 h. Furthermore, GDF11 activated Smad2/3 signaling in HepG2 cells. smmc 112-116 SMAD family member 2 Homo sapiens 170-177 29552208-7 2018 Annexin V/PI double staining showed that apatinib induced the apoptosis of SMMC-7721 cells in a concentration-dependent manner. smmc 75-79 annexin A5 Homo sapiens 0-9 29563756-7 2018 The proliferation and metastasis ability of SMMC-7721 and HepG2 cells was increased after PAR2 overexpression, while knockdown of PAR2 decreased the proliferation and metastasis ability of SMMC-7721 and HepG2 cells. smmc 44-48 F2R like trypsin receptor 1 Homo sapiens 90-94 29434780-11 2018 Berbamine triggered Cyto c release from SMMC-7721 cell nuclei to the cytoplasm. smmc 40-44 cytochrome c, somatic Homo sapiens 20-26 30321081-5 2018 We found that the downregulation or complete depletion of SND1 enhanced the apoptosis levels of HepG2 and SMMC-7721 cells upon stimulation with 5-Fu (5-fluorouracil), a chemotherapeutic drug for HCC (hepatocellular carcinoma). smmc 106-110 staphylococcal nuclease and tudor domain containing 1 Homo sapiens 58-62 29089079-0 2017 [18beta-glycyrrhetinic acid piperazine derivative A30 inhibits the proliferation of SMMC-7721 hepatoma cells]. smmc 84-88 immunoglobulin kappa variable 1-17 Homo sapiens 50-53 28901442-8 2017 The in vitro SMMC-7721 cellular uptake of 68Ga-NGR was significantly higher than that of 18F-FDG (1.23+-0.11 vs. 0.515+-0.14%; P<0.01). smmc 13-17 reticulon 4 receptor Homo sapiens 47-50 28943923-4 2017 Western blotting and an immunofluorescence assay revealed the high level of PEPT1 protein expression in hepatocarcinoma Bel-7402, SMMC-7721, HepG2, HEP3B, SK-HEP-1 cell lines. smmc 130-134 solute carrier family 15 member 1 Homo sapiens 76-81 28928813-3 2017 The present study demonstrated that HSP70 expression was higher in tested HCC cell lines, compared with the normal hepatocyte LO2, and the suppression of HSP70 significantly inhibited the proliferation of SMMC-7721 and Hep3B cells. smmc 205-209 heat shock protein family A (Hsp70) member 4 Homo sapiens 154-159 29089079-1 2017 Objective To investigate the mechanism of 18beta-glycyrrhetinic acid (GA) piperazine derivative A30 on the antiproliferation of hepatocellular carcinoma SMMC-7721 cells in vitro. smmc 153-157 immunoglobulin kappa variable 1-17 Homo sapiens 96-99 29089079-10 2017 Conclusion The 18beta-GA piperazine derivative A30 can inhibit the proliferation of SMMC-7721 cells in vitro, and the inhibitory effect is stronger than that of 18beta-GA. smmc 84-88 immunoglobulin kappa variable 1-17 Homo sapiens 47-50 28919777-8 2017 RESULTS: Syt-7 mRNA levels were highly expressed in Huh-7 and Hep3B cells; moderately expressed in SMMC-7721, HepG2, and BEL-7402 cells; and lowly expressed in normal hepatocytes L-O2. smmc 99-103 synaptotagmin 7 Homo sapiens 9-14 28789402-6 2017 The results of the present study suggest that esculetin inhibited the Wnt/beta-catenin signaling pathway in SMMC-7721 cells and may have potential as an effective anti-cancer drug, acting to inhibit the Wnt/beta-catenin signaling pathway. smmc 108-112 catenin beta 1 Homo sapiens 74-86 28677802-4 2017 In this study, HCC EMT was induced by the treatment of IL-6 and various concentrations of NCTD (0, 30, 60 and 120 microM) were treated with HCC cell lines, HCCLM3 and SMMC-7721. smmc 167-171 interleukin 6 Homo sapiens 55-59 27151580-9 2017 Western blot analysis revealed that the upregulation of BAX, downregulation of Bcl-2, activation of poly-(ADP-ribose)-polymerase (PARP), and the release of cytochrome c were observed in cells treated with the combination of DFP/VC, which showed that the mechanism of anticancer activity in the SMMC-7721 hepatocarcinoma cells involved induction of apoptosis. smmc 294-298 BCL2 associated X, apoptosis regulator Homo sapiens 56-59 28177662-0 2017 Esculetin induces apoptosis of SMMC-7721 cells through IGF-1/PI3K/Akt-mediated mitochondrial pathways. smmc 31-35 insulin like growth factor 1 Homo sapiens 55-60 28177662-0 2017 Esculetin induces apoptosis of SMMC-7721 cells through IGF-1/PI3K/Akt-mediated mitochondrial pathways. smmc 31-35 AKT serine/threonine kinase 1 Homo sapiens 66-69 28177662-8 2017 These results indicated that esculetin induced the apoptosis of SMMC-7721 cells through IGF-1/PI3K/Akt-regulated mitochondrial dysfunction. smmc 64-68 insulin like growth factor 1 Homo sapiens 88-93 28177662-8 2017 These results indicated that esculetin induced the apoptosis of SMMC-7721 cells through IGF-1/PI3K/Akt-regulated mitochondrial dysfunction. smmc 64-68 AKT serine/threonine kinase 1 Homo sapiens 99-102 27151580-9 2017 Western blot analysis revealed that the upregulation of BAX, downregulation of Bcl-2, activation of poly-(ADP-ribose)-polymerase (PARP), and the release of cytochrome c were observed in cells treated with the combination of DFP/VC, which showed that the mechanism of anticancer activity in the SMMC-7721 hepatocarcinoma cells involved induction of apoptosis. smmc 294-298 cytochrome c, somatic Homo sapiens 156-168 28339081-8 2017 Moreover, knockdown of DNMT1 by siRNA restored RIZ1 expression in HCC cell SMMC-7721 and reduced methylated CpG sites of RIZ1. smmc 75-79 DNA methyltransferase 1 Homo sapiens 23-28 28611520-4 2017 The effects of NDC80 silencing on SMMC-7721 cell proliferation were evaluated by Cellomics ArrayScan VTI imaging. smmc 34-38 NDC80 kinetochore complex component Homo sapiens 15-20 28422734-5 2017 KPNA2 knockdown also inhibited colony formation ability, induced cell cycle arrest and cellular apoptosis in two hepatocellular carcinoma cell lines, HepG2 and SMMC-7721. smmc 160-164 karyopherin subunit alpha 2 Homo sapiens 0-5 28440458-5 2017 When CBS was overexpressed in human hepatoma HepG2 and SMMC-7721 cells, inhibition of endogenous CBS/H2S significantly reduced their viability and growth rate, as well as the proliferation of SMMC-7721 cells. smmc 55-59 cystathionine beta-synthase Homo sapiens 5-8 28440458-5 2017 When CBS was overexpressed in human hepatoma HepG2 and SMMC-7721 cells, inhibition of endogenous CBS/H2S significantly reduced their viability and growth rate, as well as the proliferation of SMMC-7721 cells. smmc 55-59 cystathionine beta-synthase Homo sapiens 97-100 28440458-5 2017 When CBS was overexpressed in human hepatoma HepG2 and SMMC-7721 cells, inhibition of endogenous CBS/H2S significantly reduced their viability and growth rate, as well as the proliferation of SMMC-7721 cells. smmc 192-196 cystathionine beta-synthase Homo sapiens 5-8 28440458-5 2017 When CBS was overexpressed in human hepatoma HepG2 and SMMC-7721 cells, inhibition of endogenous CBS/H2S significantly reduced their viability and growth rate, as well as the proliferation of SMMC-7721 cells. smmc 192-196 cystathionine beta-synthase Homo sapiens 97-100 28440458-7 2017 Heme oxygenase-1 (HO-1; a microsomal enzyme) expression was significantly decreased while the reactive oxygen species (ROS) level was increased in the CBS siRNA-transfected SMMC-7721 cells. smmc 173-177 heme oxygenase 1 Homo sapiens 0-16 28440458-7 2017 Heme oxygenase-1 (HO-1; a microsomal enzyme) expression was significantly decreased while the reactive oxygen species (ROS) level was increased in the CBS siRNA-transfected SMMC-7721 cells. smmc 173-177 cystathionine beta-synthase Homo sapiens 151-154 28529597-8 2017 miR-638 expression was significantly lower in SMMC-7721 (P=0.021), HepG2 (P=0.005) and Hep3B (P=0.003) cells compared with the healthy human hepatic HL-7702 cell line. smmc 46-50 microRNA 638 Homo sapiens 0-7 28339022-3 2017 Our results showed that VK2 acted synergistically with ethanol (EtOH) to inhibit the viability of Smmc-7721 cells, mainly because cytochrome P450 2E1 (CYP2E1) was activated by EtOH. smmc 98-102 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 130-149 28339081-8 2017 Moreover, knockdown of DNMT1 by siRNA restored RIZ1 expression in HCC cell SMMC-7721 and reduced methylated CpG sites of RIZ1. smmc 75-79 PR/SET domain 2 Homo sapiens 47-51 28339022-3 2017 Our results showed that VK2 acted synergistically with ethanol (EtOH) to inhibit the viability of Smmc-7721 cells, mainly because cytochrome P450 2E1 (CYP2E1) was activated by EtOH. smmc 98-102 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 151-157 28413501-10 2017 FCM indicated that USP39 knockdown led to G2/M arrest and induced apoptosis in SMMC-7721 cells. smmc 79-83 ubiquitin specific peptidase 39 Homo sapiens 19-24 27507614-6 2016 In vivo assays showed that mice injected with SMMC-7721 + control cells had bigger tumor nodules than those injected with SMMC-7721 + NKD1. smmc 122-126 NKD inhibitor of WNT signaling pathway 1 Homo sapiens 134-138 26944057-5 2016 Western blot study also detected higher Armc8 expression in hepatocellular carcinoma cells including HepG2, HCC97L, and SMMC-7721 than in human hepatic cell Bel-7402. smmc 120-124 armadillo repeat containing 8 Homo sapiens 40-45 27602166-8 2016 It was found that PRDX2 knockdown augmented H2O2-induced cell death in SMMC-7721 cells, whereas PRDX2 overexpression exhibited opposite effects. smmc 71-75 peroxiredoxin 2 Homo sapiens 18-23 27367026-5 2016 MTS assay found that SIRT3 overexpression sensitized liver cancer cells to chemotherapeutic agents and sorafenib in SMMC-7721, Huh-7 and PLC/PRF/5 cell lines. smmc 116-120 sirtuin 3 Homo sapiens 21-26 27421660-6 2016 Ad-ING4-PTEN cooperatively inhibited cell growth, stimulated apoptosis, and suppressed invasion in both HCC cells, and regulated cell cycle in SMMC-7721. smmc 143-147 inhibitor of growth family member 4 Homo sapiens 3-7 27421660-6 2016 Ad-ING4-PTEN cooperatively inhibited cell growth, stimulated apoptosis, and suppressed invasion in both HCC cells, and regulated cell cycle in SMMC-7721. smmc 143-147 phosphatase and tensin homolog Homo sapiens 8-12 29441916-3 2016 In this study, we explored the effect of oleanolic acid derivatives on the Wnt/beta-catenin signaling pathway in human hepatocellular carcinoma SMMC-7721 cells. smmc 144-148 catenin beta 1 Homo sapiens 79-91 29441916-5 2016 Treatment of SMMC-7721 cells with oleanolic acid derivatives led to the downregulation of the mRNA and protein levels of beta-catenin, c-myc, and cyclin D1. smmc 13-17 catenin beta 1 Homo sapiens 121-133 29441916-5 2016 Treatment of SMMC-7721 cells with oleanolic acid derivatives led to the downregulation of the mRNA and protein levels of beta-catenin, c-myc, and cyclin D1. smmc 13-17 MYC proto-oncogene, bHLH transcription factor Homo sapiens 135-140 29441916-5 2016 Treatment of SMMC-7721 cells with oleanolic acid derivatives led to the downregulation of the mRNA and protein levels of beta-catenin, c-myc, and cyclin D1. smmc 13-17 cyclin D1 Homo sapiens 146-155 29441916-8 2016 Our results suggest that oleanolic acid derivatives inhibit the Wnt/beta-catenin signaling pathway by stimulating the phosphorylation of beta-catenin (Ser33/37/Thr41) in human SMMC-7721 cells. smmc 176-180 catenin beta 1 Homo sapiens 68-80 29441916-8 2016 Our results suggest that oleanolic acid derivatives inhibit the Wnt/beta-catenin signaling pathway by stimulating the phosphorylation of beta-catenin (Ser33/37/Thr41) in human SMMC-7721 cells. smmc 176-180 catenin beta 1 Homo sapiens 137-149 27059495-8 2016 Subsequently, the antitumor efficacy in vitro (SMMC-7721 cell line) and in vivo (H22 xenografts) was remarkably enhanced indicated that PAA-ATO-MSN improved the antitumor effect of the drug. smmc 47-51 moesin Homo sapiens 144-147 26927562-4 2016 miR-130b inhibitor synthesized artificially was transfected into SMMC-7721 cells in vitro. smmc 65-69 microRNA 130b Homo sapiens 0-8 26968781-8 2016 KEY FINDINGS: MiR-30c could increase the expression of NKG2D and CD107a on NKL cells, and enhance cytotoxic ability of NKL cells to kill SMMC-7721 cells. smmc 137-141 microRNA 30c-1 Homo sapiens 14-21 26769711-8 2016 Semi-quantitative real-time RCP showed that HsLDHB only existed in hepatocarcinoma cell SMMC-7721. smmc 88-92 CGRP receptor component Homo sapiens 28-31 29897188-4 2016 Compared with the control group, SMMC-7721 cells exhibited an increase in cell viability, invasion ability, ROS levels and ODC protein after exposure to 150 mumol L(-1) sodium nitrite and ammonium chloride mixture for 24 h. The invasive activity was reduced by ROS scavenger N-acetycysteine (NAC) in SMMC-7721 cells. smmc 33-37 ornithine decarboxylase 1 Homo sapiens 123-126 27082540-5 2016 The protein expression of SLC44A5 was notably high in MHCC-97H and SMMC-7721 cells compared with that in four other HCC cell lines. smmc 67-71 solute carrier family 44 member 5 Homo sapiens 26-33 27082540-7 2016 Furthermore, SLC44A5 knockdown cells also exhibited cell apoptosis by reducing the expression levels of apoptosis markers, caspase-3 and caspase-9 in MHCC-97H and SMMC-7721 cells, and suppressed invasion. smmc 163-167 solute carrier family 44 member 5 Homo sapiens 13-20 26998020-0 2016 Inhibition of mTOR promotes hyperthermia sensitivity in SMMC-7721 human hepatocellular carcinoma cell line. smmc 56-60 mechanistic target of rapamycin kinase Homo sapiens 14-18 26639052-4 2015 The half-maximum inhibiting concentration (IC50) of alpha-Hed-CS-CD147-NPs in human liver cancer cell lines HepG2 and SMMC-7721 was lower than that of free alpha-Hed and alpha-Hed-CS-NPs. smmc 118-122 basigin (Ok blood group) Homo sapiens 65-70 26893696-9 2016 Conversely, SMMC-7721 human HCC cells transfected with a miR-497 inhibitor exhibited enhanced colony formation and tumor growth. smmc 12-16 microRNA 497 Homo sapiens 57-64 26700460-8 2016 F-18-2-fluoro-2-deoxyglucose accumulation assay measured by positron emission tomography elucidated that 11betaHSD1 reduced glucose uptake and glycolysis in SMMC-7721 cells in vitro, and intrahepatic metastasis foci and subcutaneous tumor growth in vivo. smmc 157-161 hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens 105-115 26531171-8 2016 Taken together, the results of the present study revealed that the knockdown of GnT-V significantly suppressed the proliferation, migration and invasion (P<0.05) of the SMMC-7721/R cells. smmc 172-176 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Homo sapiens 80-85 26341139-3 2015 SMMC-7721 and HepG2 hepatoma cell lines were transfected with HBx-expressing plasmid. smmc 0-4 X protein Hepatitis B virus 62-65 26677902-0 2015 Induction of cell cycle arrest via the p21, p27-cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol. smmc 75-79 cyclin dependent kinase inhibitor 1A Homo sapiens 39-42 26677902-0 2015 Induction of cell cycle arrest via the p21, p27-cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol. smmc 75-79 interferon alpha inducible protein 27 Homo sapiens 44-47 26677902-0 2015 Induction of cell cycle arrest via the p21, p27-cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol. smmc 75-79 cyclin dependent kinase 2 Homo sapiens 59-63 26677902-6 2015 The results demonstrated for the first time that clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 cells via the p21, p27-cyclin E,A/Cdk2 pathway. smmc 112-116 interferon alpha inducible protein 27 Homo sapiens 141-144 26341139-7 2015 JMJd2B, as a specific target of H3K9me3 for demethylation, was inversely correlated with the levels of H3K9me3 in SMMC-7721 (r=-0.666, P<0.05) and HepG2 cells (r=-0.625, P<0.05). smmc 114-118 lysine demethylase 4B Homo sapiens 0-6 26111001-6 2015 However, SMMC-7721 cells had higher levels of basal autophagy and mTORC2-mediated feedback activation of Akt than HepG2 cells, which may render SMMC-7721 cells to be more resistant to metformin-induced inhibition of cell growth. smmc 9-13 CREB regulated transcription coactivator 2 Mus musculus 66-72 26614997-5 2015 RESULTS: The expression of WIF1 in hepatocellular carcinoma cell lines was lower than that in the normal liver cell lines (P < 0.01); while there was basically no expression of WIF1 in the human highly metastatic cell line MHCC-97 and moderate expression in HepG2 and SMMC-7721. smmc 271-275 WNT inhibitory factor 1 Homo sapiens 27-31 26459497-7 2015 Small interfering RNA-mediated knockdown of PKCbeta in the SMMC-7721 cells significantly attenuated the tumor inhibitory effects of TAS9. smmc 59-63 protein kinase C beta Homo sapiens 44-51 26398332-3 2015 In the present study, it was found that MUC1 gene silencing not only resulted in the inhibition of SMMC-7721 cell growth, determined using a clone formation assay in vitro and a tumor xenograft mouse model with an in vivo imaging system, but also induced apoptotic alterations in SMMC-7721 cells, determined using Hoechst 33342 staining, flow cytometry with an Annexin V-PE staining and a DNA ladder assay. smmc 99-103 mucin 1, cell surface associated Homo sapiens 40-44 26398332-3 2015 In the present study, it was found that MUC1 gene silencing not only resulted in the inhibition of SMMC-7721 cell growth, determined using a clone formation assay in vitro and a tumor xenograft mouse model with an in vivo imaging system, but also induced apoptotic alterations in SMMC-7721 cells, determined using Hoechst 33342 staining, flow cytometry with an Annexin V-PE staining and a DNA ladder assay. smmc 280-284 mucin 1, cell surface associated Homo sapiens 40-44 26499380-8 2015 Also, MTT assay results found that overexpression or recombinant Klotho administration suppressed the proliferation of liver cancer cells HepG2 and SMMC-7721. smmc 148-152 klotho Homo sapiens 65-71 26252057-10 2015 Knockdown of GRP78 using siRNA or proteosome inhibitor enhanced the cytotoxicity of the combination of SOR with MEL-treatment in SMMC-7721 cells. smmc 129-133 heat shock protein family A (Hsp70) member 5 Homo sapiens 13-18 25787750-0 2015 A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma SMMC-7721 cells via modulating AUF-1 signaling pathway. smmc 77-81 heterogeneous nuclear ribonucleoprotein D Homo sapiens 108-113 25787750-6 2015 In addition, the hematoxylin-eosin (H & E) staining showed that the TP-1 significantly inhibited the lung metastasis of liver cancer in mice orthotopic implanted with SMMC-7721 tumor tissue. smmc 171-175 transition protein 1 Mus musculus 72-76 26111001-6 2015 However, SMMC-7721 cells had higher levels of basal autophagy and mTORC2-mediated feedback activation of Akt than HepG2 cells, which may render SMMC-7721 cells to be more resistant to metformin-induced inhibition of cell growth. smmc 9-13 AKT serine/threonine kinase 1 Homo sapiens 105-108 26111001-6 2015 However, SMMC-7721 cells had higher levels of basal autophagy and mTORC2-mediated feedback activation of Akt than HepG2 cells, which may render SMMC-7721 cells to be more resistant to metformin-induced inhibition of cell growth. smmc 144-148 CREB regulated transcription coactivator 2 Mus musculus 66-72 26111001-6 2015 However, SMMC-7721 cells had higher levels of basal autophagy and mTORC2-mediated feedback activation of Akt than HepG2 cells, which may render SMMC-7721 cells to be more resistant to metformin-induced inhibition of cell growth. smmc 144-148 AKT serine/threonine kinase 1 Homo sapiens 105-108 25597429-3 2015 Presently, we found that TP-1 at doses of 0.5, 1 and 2mg/kg significantly inhibited tumor growth and metastasis to the lung in mice bearing HCC SMMC-7721 tumors without toxicity. smmc 144-148 transition protein 1 Mus musculus 25-29 25607114-0 2015 Resistance of SMMC-7721 hepatoma cells to etoposide in hypoxia is reversed by VEGF inhibitor. smmc 14-18 vascular endothelial growth factor A Homo sapiens 78-82 25607114-3 2015 Increased levels of hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) were observed when SMMC-7721 cells were exposed to hypoxia, and exposure of tumor cells to hypoxia impaired etoposide-induced DNA damage, as indicated by the failure of upregulation of gammaHA2X. smmc 130-134 hypoxia inducible factor 1 subunit alpha Homo sapiens 20-51 25607114-3 2015 Increased levels of hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) were observed when SMMC-7721 cells were exposed to hypoxia, and exposure of tumor cells to hypoxia impaired etoposide-induced DNA damage, as indicated by the failure of upregulation of gammaHA2X. smmc 130-134 hypoxia inducible factor 1 subunit alpha Homo sapiens 53-63 25607114-3 2015 Increased levels of hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) were observed when SMMC-7721 cells were exposed to hypoxia, and exposure of tumor cells to hypoxia impaired etoposide-induced DNA damage, as indicated by the failure of upregulation of gammaHA2X. smmc 130-134 vascular endothelial growth factor A Homo sapiens 69-103 25607114-3 2015 Increased levels of hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) were observed when SMMC-7721 cells were exposed to hypoxia, and exposure of tumor cells to hypoxia impaired etoposide-induced DNA damage, as indicated by the failure of upregulation of gammaHA2X. smmc 130-134 vascular endothelial growth factor A Homo sapiens 105-109 25457485-3 2015 Three of the compounds showed inhibitory activities against HL-60, SMMC-7721, A-549 and MCF-7 cells with IC50 values of 15.0-40.0 muM. smmc 67-71 latexin Homo sapiens 130-133 25534361-9 2015 FAK and PI3K inhibitors, as well as integrin beta1 antibodies, increased the radiation-induced apoptosis of SMMC-7721 cells. smmc 108-112 protein tyrosine kinase 2 Homo sapiens 0-3 25889525-8 2015 Furthermore, suppression of USP39 arrested cell cycle progression at G2/M phase in SMMC-7721cells. smmc 83-87 ubiquitin specific peptidase 39 Homo sapiens 28-33 25756649-18 2015 Cusimano &amp; Hett Tuber in tumor therapy, anti-tumor activity on cancer cell line in descending order is SGC-7901 > SMMC-7721 > MCF-7 > HT-29 > A549 > HeLa > MDA-MB-231. smmc 125-129 serglycin Mus musculus 111-114 25776511-5 2015 Furthermore, pretreating with anti-EGFR monoclonal antibody reduced intracellular accumulation of GE11-DOX in SMMC-7721, indicating the involvement of EGFR pathway in the transport of conjugate. smmc 110-114 epidermal growth factor receptor Homo sapiens 35-39 25776511-5 2015 Furthermore, pretreating with anti-EGFR monoclonal antibody reduced intracellular accumulation of GE11-DOX in SMMC-7721, indicating the involvement of EGFR pathway in the transport of conjugate. smmc 110-114 epidermal growth factor receptor Homo sapiens 151-155 25308857-7 2015 Moreover, knockout of HAb18G/CD147 expression also induced SMMC-K7721 cells to undergo apoptosis compared to SMMC-7721 and SMMC-R7721 (P < 0.01). smmc 59-63 basigin (Ok blood group) Homo sapiens 29-34 25534361-9 2015 FAK and PI3K inhibitors, as well as integrin beta1 antibodies, increased the radiation-induced apoptosis of SMMC-7721 cells. smmc 108-112 integrin subunit beta 1 Homo sapiens 36-50 25270731-11 2014 The expression of annexin II was lower in the HepG2.2.15 cells compared with the SMMC-7721 and HepG2 cells and the fluorescence signal of annexin II in the HepG2 cells was brighter than in the HepG2.2.15 cells. smmc 81-85 annexin A2 Homo sapiens 18-28 25270731-11 2014 The expression of annexin II was lower in the HepG2.2.15 cells compared with the SMMC-7721 and HepG2 cells and the fluorescence signal of annexin II in the HepG2 cells was brighter than in the HepG2.2.15 cells. smmc 81-85 annexin A2 Homo sapiens 138-148 24784470-2 2014 In addition, this study examined how VTN inhibits the induction of apoptosis in SMMC-7721 cells by 3,3"-diindolylmethane (DIM), a metabolite of natural phytochemicals, and preliminarily investigated the signaling molecules involved in this process. smmc 80-84 vitronectin Homo sapiens 37-40 25442303-3 2014 Among these compounds, compound 8d showed the best inhibitory effect against SMMC-7721 cells, with IC50 value of 2.84 muM. smmc 77-81 latexin Homo sapiens 118-121 24964053-3 2014 Annexin V-FITC/PI double staining further confirmed that FA-DTX-OSWNT-SLN induced higher apoptotic rates on SMMC-7721 cells. smmc 108-112 annexin A5 Homo sapiens 0-9 24867957-5 2014 Here we expressed human matriptase-2 in HEK293 and hepatic BEL-7402, SMMC-7721, and QGY-7703 cells. smmc 69-73 transmembrane serine protease 6 Homo sapiens 24-36 24821075-9 2014 PE-induced apoptosis was accompanied by a decrease in Erk phospho-rylation and by the activation of Stat1/2 phosphorylation in SMMC-7721 cells. smmc 127-131 signal transducer and activator of transcription 1 Homo sapiens 100-107 26027111-13 2014 The results of Western blot assay showed that this ratio of drugs could significantly increase the protein expression of Bax,P53 and P21 and decreased the expression of BCL-2, Casepase-3, p-Erk, p-Ras and p-c-Raf in SMMC-7721 cells. smmc 216-220 BCL2 associated X, apoptosis regulator Homo sapiens 121-124 26027111-13 2014 The results of Western blot assay showed that this ratio of drugs could significantly increase the protein expression of Bax,P53 and P21 and decreased the expression of BCL-2, Casepase-3, p-Erk, p-Ras and p-c-Raf in SMMC-7721 cells. smmc 216-220 tumor protein p53 Homo sapiens 125-128 26027111-13 2014 The results of Western blot assay showed that this ratio of drugs could significantly increase the protein expression of Bax,P53 and P21 and decreased the expression of BCL-2, Casepase-3, p-Erk, p-Ras and p-c-Raf in SMMC-7721 cells. smmc 216-220 H3 histone pseudogene 16 Homo sapiens 133-136 26027111-13 2014 The results of Western blot assay showed that this ratio of drugs could significantly increase the protein expression of Bax,P53 and P21 and decreased the expression of BCL-2, Casepase-3, p-Erk, p-Ras and p-c-Raf in SMMC-7721 cells. smmc 216-220 BCL2 apoptosis regulator Homo sapiens 169-174 26027111-13 2014 The results of Western blot assay showed that this ratio of drugs could significantly increase the protein expression of Bax,P53 and P21 and decreased the expression of BCL-2, Casepase-3, p-Erk, p-Ras and p-c-Raf in SMMC-7721 cells. smmc 216-220 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 176-193 26027111-13 2014 The results of Western blot assay showed that this ratio of drugs could significantly increase the protein expression of Bax,P53 and P21 and decreased the expression of BCL-2, Casepase-3, p-Erk, p-Ras and p-c-Raf in SMMC-7721 cells. smmc 216-220 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 207-212 26202642-10 2014 Silencing of CD147 significantly inhibited the glycolytic rate and induced apoptosis in SMMC-7721 cells. smmc 88-92 basigin (Ok blood group) Homo sapiens 13-18 25286681-3 2014 The autophagy of SMMC 7721 induced with feverfew lactone was assessed by acridine orange staining, autophagic marker LC3 and p62 detecting and autophagic flows analyzing. smmc 17-21 microtubule associated protein 1 light chain 3 alpha Homo sapiens 117-120 26158169-5 2014 METHODOLOGY: We treated SMMC-7721 cells with a known STAT3 activator, epithelial growth factor (EGF); in the absence or presence of JSI-124, a selective STAT3 inhibitor. smmc 24-28 epidermal growth factor Homo sapiens 70-94 24784470-5 2014 Flow cytometry and Western blotting assays were used to observe the inhibitory effects of VTN on DIM-induced apoptosis in SMMC-7721 cells and changes in the expression levels of the signaling molecules involved in this process. smmc 122-126 vitronectin Homo sapiens 90-93 24784470-7 2014 Under in vitro experimental conditions, VTN contributed to the growth of SMMC-7721 hepatoma cells and protected them from the effects of an apoptosis-inducing agent. smmc 73-77 vitronectin Homo sapiens 40-43 23621665-10 2014 The overexpression of miR-145 was able to suppress tumor MHCC-97H cell invasion, whereas the knockdown of miR-145 expression induced SMMC-7721 cell invasion. smmc 133-137 microRNA 145 Homo sapiens 106-113 24770339-7 2014 Over-expression of Numb increased proliferation in SMMC-7721 and BEL-7402 cells, while knock-down of Numb showed the opposite effect. smmc 51-55 NUMB endocytic adaptor protein Homo sapiens 19-23 24651440-6 2014 Overexpression of Skp2 significantly inhibited LK-A-induced cell cycle arrest in SMMC-7721 cells, suggesting that LK-A may target Skp2 to arrest cells at the G2/M phase. smmc 81-85 S-phase kinase associated protein 2 Homo sapiens 18-22 24127012-0 2014 Synergistic effect of EMS1-shRNA and sorafenib on proliferation, migration, invasion and endocytosis of SMMC-7721. smmc 104-108 cortactin Homo sapiens 22-26 24127012-1 2014 To investigate the synergistic effect of EMS1-PSilencer4.1-shRNA (EMS1-shRNA) and sorafenib on biological behaviors of HCC cell line SMMC-7721. smmc 133-137 cortactin Homo sapiens 41-45 24064680-12 2013 qPCR and western blot analysis demonstrated that ZHX1 was efficiently expressed in SMMC-7721 cells and overexpression of ZHX1 may inhibit the proliferation of SMMC-7721 cells. smmc 83-87 zinc fingers and homeoboxes 1 Homo sapiens 49-53 24064800-4 2013 Furthermore, caudatin treatment resulted in a decrease in beta-catenin and GSK3beta in SMMC-7721 cells, with a concomitant reduction in metastatic capability and expression of Wnt signaling pathway targeted genes including cox-2, mmp-2 and mmp-9. smmc 87-91 catenin beta 1 Homo sapiens 58-70 24064800-4 2013 Furthermore, caudatin treatment resulted in a decrease in beta-catenin and GSK3beta in SMMC-7721 cells, with a concomitant reduction in metastatic capability and expression of Wnt signaling pathway targeted genes including cox-2, mmp-2 and mmp-9. smmc 87-91 glycogen synthase kinase 3 beta Homo sapiens 75-83 23530500-5 2014 RESULTS: We identified 102 unique proteins including p16, maspin, PRDX6, PSMB7, MYL6, PHB, and HSP27 with alteration in SMMC- 7721/5-FU. smmc 120-124 cyclin dependent kinase inhibitor 2A Homo sapiens 53-56 23530500-5 2014 RESULTS: We identified 102 unique proteins including p16, maspin, PRDX6, PSMB7, MYL6, PHB, and HSP27 with alteration in SMMC- 7721/5-FU. smmc 120-124 serpin family B member 5 Homo sapiens 58-64 23530500-5 2014 RESULTS: We identified 102 unique proteins including p16, maspin, PRDX6, PSMB7, MYL6, PHB, and HSP27 with alteration in SMMC- 7721/5-FU. smmc 120-124 peroxiredoxin 6 Homo sapiens 66-71 23530500-5 2014 RESULTS: We identified 102 unique proteins including p16, maspin, PRDX6, PSMB7, MYL6, PHB, and HSP27 with alteration in SMMC- 7721/5-FU. smmc 120-124 proteasome 20S subunit beta 7 Homo sapiens 73-78 23530500-5 2014 RESULTS: We identified 102 unique proteins including p16, maspin, PRDX6, PSMB7, MYL6, PHB, and HSP27 with alteration in SMMC- 7721/5-FU. smmc 120-124 myosin light chain 6 Homo sapiens 80-84 23530500-5 2014 RESULTS: We identified 102 unique proteins including p16, maspin, PRDX6, PSMB7, MYL6, PHB, and HSP27 with alteration in SMMC- 7721/5-FU. smmc 120-124 prohibitin 1 Homo sapiens 86-89 23530500-5 2014 RESULTS: We identified 102 unique proteins including p16, maspin, PRDX6, PSMB7, MYL6, PHB, and HSP27 with alteration in SMMC- 7721/5-FU. smmc 120-124 heat shock protein family B (small) member 1 Homo sapiens 95-100 23563597-4 2013 Ad5/F35-siAPE1 significantly enhanced the cytotoxic effect of SMMC-7721 cells to Ad-p53 in cell survival assays, associated with increased cell apoptosis. smmc 62-66 Alzheimer disease, familial, type 5 Homo sapiens 0-3 23970349-3 2013 In this study, we aimed to isolate and characterize a small population of CD133+ cells that existed in the HCC cell line SMMC-7721 by MACS and investigated the possible roles of 8-bromo-7-methoxychrysin (BrMC), a synthetic analogue of chrysin, in inhibiting the properties of CD133+ sphere-forming cells (SFCs) derived from the HCC cell line SMMC-7721, namely liver cancer stem cells (LCSCs). smmc 121-125 prominin 1 Homo sapiens 74-79 23970349-3 2013 In this study, we aimed to isolate and characterize a small population of CD133+ cells that existed in the HCC cell line SMMC-7721 by MACS and investigated the possible roles of 8-bromo-7-methoxychrysin (BrMC), a synthetic analogue of chrysin, in inhibiting the properties of CD133+ sphere-forming cells (SFCs) derived from the HCC cell line SMMC-7721, namely liver cancer stem cells (LCSCs). smmc 121-125 HCC Homo sapiens 107-110 23970349-3 2013 In this study, we aimed to isolate and characterize a small population of CD133+ cells that existed in the HCC cell line SMMC-7721 by MACS and investigated the possible roles of 8-bromo-7-methoxychrysin (BrMC), a synthetic analogue of chrysin, in inhibiting the properties of CD133+ sphere-forming cells (SFCs) derived from the HCC cell line SMMC-7721, namely liver cancer stem cells (LCSCs). smmc 121-125 myristoylated alanine rich protein kinase C substrate Homo sapiens 134-138 23563597-4 2013 Ad5/F35-siAPE1 significantly enhanced the cytotoxic effect of SMMC-7721 cells to Ad-p53 in cell survival assays, associated with increased cell apoptosis. smmc 62-66 tumor protein p53 Homo sapiens 84-87 23563597-5 2013 Moreover, administration of Ad5/F35-siAPE1 and Ad-p53 into nude mice resulted in tumor growth inhibition and apoptosis induction in SMMC-7721 xenografts compared to administration of either agent alone. smmc 132-136 Alzheimer disease, familial, type 5 Homo sapiens 28-31 23563597-5 2013 Moreover, administration of Ad5/F35-siAPE1 and Ad-p53 into nude mice resulted in tumor growth inhibition and apoptosis induction in SMMC-7721 xenografts compared to administration of either agent alone. smmc 132-136 transformation related protein 53, pseudogene Mus musculus 50-53 23397112-4 2013 In this study, we found that SMMC-7721 or BEL-7404 cells were induced to apoptosis by STS, meanwhile the DNMT3B protein and mRNA level were decreased. smmc 29-33 DNA methyltransferase 3 beta Homo sapiens 105-111 23621231-0 2013 Inhibition of growth and induction of differentiation of SMMC-7721 human hepatocellular carcinoma cells by Oncostatin M. smmc 57-61 oncostatin M Homo sapiens 107-119 23811557-7 2013 TGOE significantly activated caspase-3 and increased the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), while decreased the phosphorylation of p38 in SMMC-7721 cells. smmc 201-205 mitogen-activated protein kinase 14 Homo sapiens 194-197 23527801-5 2013 Contrarily, PAI-2 protein expression was gradually reducing from SMMC-7721, MHCC97-L, to MHCC97-H (MHCC97-H vs. MHCC97-L, P<0.001; MHCC97-H vs. SMMC-7721, P=0.001; MHCC97-L vs. SMMC-7721, P=0.001). smmc 65-69 serpin family B member 2 Homo sapiens 12-17 23527801-5 2013 Contrarily, PAI-2 protein expression was gradually reducing from SMMC-7721, MHCC97-L, to MHCC97-H (MHCC97-H vs. MHCC97-L, P<0.001; MHCC97-H vs. SMMC-7721, P=0.001; MHCC97-L vs. SMMC-7721, P=0.001). smmc 147-151 serpin family B member 2 Homo sapiens 12-17 23527801-5 2013 Contrarily, PAI-2 protein expression was gradually reducing from SMMC-7721, MHCC97-L, to MHCC97-H (MHCC97-H vs. MHCC97-L, P<0.001; MHCC97-H vs. SMMC-7721, P=0.001; MHCC97-L vs. SMMC-7721, P=0.001). smmc 147-151 serpin family B member 2 Homo sapiens 12-17 23745253-2 2013 METHODS: The cells transfected with SMMC/NNMT abbreviated as S/NNMT, parental cells including the negative control which transfected with SMMC/pcDNA3. smmc 36-40 nicotinamide N-methyltransferase Homo sapiens 63-67 23042506-11 2013 Knockdown of HMGB1 downregulated the expression of p-AKT, Ki-67 and MMP-2, inhibited the proliferative activities and metastatic potential of SMMC-7721 cells, induced cell cycle arrest and apoptosis, and slowed the growth of xenograft tumors. smmc 166-170 high mobility group box 1 Homo sapiens 13-18 22980656-0 2012 [Downregulation of HSP70 gene expression and apoptosis in human hepatocellular carcinoma SMMC-7721 cells induced by nimesulide in vitro]. smmc 89-93 heat shock protein family A (Hsp70) member 4 Homo sapiens 19-24 23326134-5 2012 To transfect the recombined plasmid vector pEGFP-CI-MOB2 into SMMC-7721 cells, the cells were cultured in Dulbecco"s Modified Eagle"s Medium with 10% fetal calf serum and glutamine, and then mixed with liposomes, Lipofectamine 2000 and the plasmid vector pEGFP-CI-MOB2. smmc 62-66 MOB kinase activator 2 Homo sapiens 43-56 21940333-2 2011 METHODOLOGY: ANGPTL3 antisense oligodeoxynucleotides was transfected into SMMC-7721 cells with Lipofectamine 2000. smmc 74-78 angiopoietin like 3 Homo sapiens 13-20 22654424-6 2012 The methylation status of hTERT promoter could be reversed in SMMC-7721 by DAC, but not in HepG2 cells. smmc 62-66 telomerase reverse transcriptase Homo sapiens 26-31 22301863-11 2012 Treatment of SMMC-7721 cells with QNT4 significantly increased cytochrome c in the cytosol, and decreased cytochrome c in the mitochondrial compartment. smmc 13-17 cytochrome c, somatic Homo sapiens 63-75 22301863-11 2012 Treatment of SMMC-7721 cells with QNT4 significantly increased cytochrome c in the cytosol, and decreased cytochrome c in the mitochondrial compartment. smmc 13-17 cytochrome c, somatic Homo sapiens 106-118 22768104-7 2012 Salubrinal, an activator of the PERK/eIF2alpha pathway, strikingly enhanced the phosphorylation of eIF2alpha in SMMC-7721 cells with no toxicity. smmc 112-116 eukaryotic translation initiation factor 2A Homo sapiens 99-108 21915726-7 2011 The transcript of NOX4 was only detected in SMMC-7721. smmc 44-48 NADPH oxidase 4 Homo sapiens 18-22 21950556-5 2011 HIF-1alpha downregulation by siRNA inhibited proliferation, induced apoptosis, and enhanced radiosensitivity in chemical hypoxic SMMC-7721 cells in vitro. smmc 129-133 hypoxia inducible factor 1 subunit alpha Homo sapiens 0-10 22378232-6 2012 The COX-2 mRNA level in the tumor tissues injected with SMMC-7721/COX-2i was markedly downregulated compared to that in the tumor tissues injected with SMMC-7721/negative shRNA. smmc 56-60 prostaglandin-endoperoxide synthase 2 Homo sapiens 4-9 22378232-6 2012 The COX-2 mRNA level in the tumor tissues injected with SMMC-7721/COX-2i was markedly downregulated compared to that in the tumor tissues injected with SMMC-7721/negative shRNA. smmc 56-60 prostaglandin-endoperoxide synthase 2 Homo sapiens 66-71 22844419-4 2012 We found that CD147-expressing cancer cells could promote HUVECs to form net-like structures resembling the neo-vasculature, whereas the ability of proliferation, migration and tube formation of HUVECs was significantly decreased in tumor conditioned medium (TCM) of SMMC-7721 cells transfected with specific CD147-siRNA. smmc 267-271 basigin (Ok blood group) Homo sapiens 14-19 22844419-4 2012 We found that CD147-expressing cancer cells could promote HUVECs to form net-like structures resembling the neo-vasculature, whereas the ability of proliferation, migration and tube formation of HUVECs was significantly decreased in tumor conditioned medium (TCM) of SMMC-7721 cells transfected with specific CD147-siRNA. smmc 267-271 basigin (Ok blood group) Homo sapiens 309-314 21940333-6 2011 RESULTS: ANGPTL3 antisense oligodeoxynucleotides were successfully transfected into SMMC-7721 cells, resulting in the significant inhibition of ANGPTL3, p38MAPK and MMP-9 mRNA expression. smmc 84-88 angiopoietin like 3 Homo sapiens 9-16 21940333-6 2011 RESULTS: ANGPTL3 antisense oligodeoxynucleotides were successfully transfected into SMMC-7721 cells, resulting in the significant inhibition of ANGPTL3, p38MAPK and MMP-9 mRNA expression. smmc 84-88 matrix metallopeptidase 9 Homo sapiens 165-170 21656365-0 2011 Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell. smmc 123-127 BCL2 apoptosis regulator Homo sapiens 83-88 21104439-4 2011 The results showed that OPN significantly enhanced the migration and invasion of SMMC-7721 cells in vitro. smmc 81-85 secreted phosphoprotein 1 Homo sapiens 24-27 21052098-3 2011 In this study, we explored the combined effect of adenovirus-mediated ING4 (Ad-ING4) gene transfer plus chemotherapy drug cisplatin (CDDP) on SMMC-7721 human hepatocarcinoma cells in vitro and in vivo, and its underlying mechanism. smmc 142-146 inhibitor of growth family member 4 Homo sapiens 70-74 21651861-5 2011 RESULTS: MAPs of hTERT epitopes including I540 (ILAKFLHWL), V461 (VYGFVRACL), L766 (LTDLQPYMRQFVAHL) and three separate peptides could impulse mDCs and then induce CTLs to specifically kill SMMC-7721, CTLs induced by MAPs had stronger cytotoxic effect compared with three separate peptides mixed(P < 0.05). smmc 190-194 telomerase reverse transcriptase Homo sapiens 17-22 21800536-6 2011 The results suggest that sodium nitrite could induce SMMC-7721 EMT by increased secretion of TGF-beta1 and IL-8. smmc 53-57 transforming growth factor beta 1 Homo sapiens 93-102 21800536-6 2011 The results suggest that sodium nitrite could induce SMMC-7721 EMT by increased secretion of TGF-beta1 and IL-8. smmc 53-57 C-X-C motif chemokine ligand 8 Homo sapiens 107-111 21052098-3 2011 In this study, we explored the combined effect of adenovirus-mediated ING4 (Ad-ING4) gene transfer plus chemotherapy drug cisplatin (CDDP) on SMMC-7721 human hepatocarcinoma cells in vitro and in vivo, and its underlying mechanism. smmc 142-146 inhibitor of growth family member 4 Homo sapiens 79-83 21052098-4 2011 We demonstrated that Ad-ING4 plus CDDP induced synergistic growth inhibition, enhanced apoptosis, and had an additive effect on upregulation of Fas, Bax, Bak, cleaved Bid, cleaved caspase-8, caspase-9, caspase-3 and cleaved PARP, and on downregulation of Bcl-2 and Bcl-X(L) in SMMC-7721 hepatocarcinoma cells. smmc 277-281 inhibitor of growth family member 4 Homo sapiens 24-28 21052098-5 2011 Moreover, Ad-ING4 plus CDDP synergistically suppressed in vivo SMMC-7721 hepatocarcinoma subcutaneous (s.c.) xenografted tumor growth and reduced tumor vessel CD34 expression and microvessel density (MVD) in athymic nude mice. smmc 63-67 inhibitor of growth family member 4 Homo sapiens 13-17 22292626-4 2011 Annexin-V/PI double staining detected by flow cytometry and expression of the relative apoptotic proteins (Bax, Bcl-2 and caspase-3) revealed a strong apoptosis-inducing competent of curcumin in SMMC-7721 cells. smmc 195-199 annexin A5 Homo sapiens 0-9 20502916-6 2011 SUMO-1 siRNA notably inhibited SMMC-7721 cells proliferation in vitro and increased the ratios of G2 phase and S phase in the cells. smmc 31-35 small ubiquitin like modifier 1 Homo sapiens 0-6 21425578-6 2011 The activities of Caspase-3,-8 and -9 all markedly enhanced after treatment in SMMC-7721 cells, while in Hep3B cells, activities of Caspase-3 and -9 enhanced, but that of Caspase-8 unchanged. smmc 79-83 caspase 3 Homo sapiens 18-37 21425578-6 2011 The activities of Caspase-3,-8 and -9 all markedly enhanced after treatment in SMMC-7721 cells, while in Hep3B cells, activities of Caspase-3 and -9 enhanced, but that of Caspase-8 unchanged. smmc 79-83 caspase 3 Homo sapiens 132-148 21425578-6 2011 The activities of Caspase-3,-8 and -9 all markedly enhanced after treatment in SMMC-7721 cells, while in Hep3B cells, activities of Caspase-3 and -9 enhanced, but that of Caspase-8 unchanged. smmc 79-83 caspase 8 Homo sapiens 171-180 22292626-6 2011 The results suggest that curcumin induction of apoptosis involves modulation of bax/bcl-2 in SMMC-7721 cells and provide a molecular basis for the development of naturally compounds as novel anticancer agents for human hepatomas. smmc 93-97 BCL2 associated X, apoptosis regulator Homo sapiens 80-83 22292626-6 2011 The results suggest that curcumin induction of apoptosis involves modulation of bax/bcl-2 in SMMC-7721 cells and provide a molecular basis for the development of naturally compounds as novel anticancer agents for human hepatomas. smmc 93-97 BCL2 apoptosis regulator Homo sapiens 84-89 21212669-2 2011 METHODS: SMMC-7721 cells were transfected with pcDNA3.1(+)-hSmac using a lipofectamine-mediated method, and then cell viability was detected by MTT assay after exposure to 10, 20, and 30 mumol/l CdCl(2). smmc 9-13 diablo IAP-binding mitochondrial protein Homo sapiens 59-64 21212669-5 2011 Furthermore, cotreatment with CdCl(2) and hSmac could enhance antiproliferative and proapoptotic effects in SMMC-7721 cells. smmc 108-112 diablo IAP-binding mitochondrial protein Homo sapiens 42-47 21211351-9 2010 In comparison with SMMC-7721 cell line, the expression of SLC35B3 gene in HepG2 cell line was higher [(0.477 +- 0.040)% vs (0.129 +- 0.004)%, P < 0.01]. smmc 19-23 solute carrier family 35 member B3 Homo sapiens 58-65 20674153-3 2010 Moreover, icariin induced a sustained activation of the phosphorylation of c-Jun N-terminal kinase (JNK) but not p38 and ERK1/2, and SP600125 (an inhibitor of JNK) almost reversed icariin-induced apoptosis in SMMC-7721 cells. smmc 209-213 mitogen-activated protein kinase 8 Homo sapiens 75-98 20674153-3 2010 Moreover, icariin induced a sustained activation of the phosphorylation of c-Jun N-terminal kinase (JNK) but not p38 and ERK1/2, and SP600125 (an inhibitor of JNK) almost reversed icariin-induced apoptosis in SMMC-7721 cells. smmc 209-213 mitogen-activated protein kinase 8 Homo sapiens 100-103 20674153-3 2010 Moreover, icariin induced a sustained activation of the phosphorylation of c-Jun N-terminal kinase (JNK) but not p38 and ERK1/2, and SP600125 (an inhibitor of JNK) almost reversed icariin-induced apoptosis in SMMC-7721 cells. smmc 209-213 mitogen-activated protein kinase 8 Homo sapiens 159-162 21472331-11 2010 In addition, the MMT assay indicated that the silencing of livin inhibited the cell growth of SMMC-7721 cells by specifically inhibiting cell mitosis. smmc 94-98 baculoviral IAP repeat containing 7 Homo sapiens 59-64 21472331-12 2010 The results also showed that the silencing of livin strongly reduced the invasive capacity of SMMC-7721 cells. smmc 94-98 baculoviral IAP repeat containing 7 Homo sapiens 46-51 21138632-12 2010 The HCCR-2 protein was up-regulated in a dose-dependent manner in the cells cultured with different concentrations of EGF for 24 h. Treatment of SMMC 7721 cells with specific inhibitor of PI3K (LY294002) suppressed EGF-induced HCCR-2 expression. smmc 145-149 LETM1 domain containing 1 Homo sapiens 4-10 21138632-12 2010 The HCCR-2 protein was up-regulated in a dose-dependent manner in the cells cultured with different concentrations of EGF for 24 h. Treatment of SMMC 7721 cells with specific inhibitor of PI3K (LY294002) suppressed EGF-induced HCCR-2 expression. smmc 145-149 LETM1 domain containing 1 Homo sapiens 227-233 20449638-6 2010 In addition, our study showed that caspase 3 was activated by caspase 8, not caspase 9, in Smmc-7721 cells treated with VK(2). smmc 91-95 caspase 3 Homo sapiens 35-44 21205476-8 2010 It is notable that both myr-Akt overexpression and MEK inhibitor U0126 inhibited endoplasmic reticulum stress-induced G0/G1 phase arrest in SMMC-7721 cells. smmc 140-144 AKT serine/threonine kinase 1 Homo sapiens 28-31 21205476-8 2010 It is notable that both myr-Akt overexpression and MEK inhibitor U0126 inhibited endoplasmic reticulum stress-induced G0/G1 phase arrest in SMMC-7721 cells. smmc 140-144 mitogen-activated protein kinase kinase 7 Homo sapiens 51-54 20449638-6 2010 In addition, our study showed that caspase 3 was activated by caspase 8, not caspase 9, in Smmc-7721 cells treated with VK(2). smmc 91-95 caspase 8 Homo sapiens 62-71 20210523-4 2010 Moreover, SMMC-7721/RV-IL-17F exhibited a significant decrease in tumor size and microvessel density as compared to the SMMC-7721/RV control when transplanted in nude mice. smmc 120-124 interleukin 17F Mus musculus 23-29 20210523-4 2010 Moreover, SMMC-7721/RV-IL-17F exhibited a significant decrease in tumor size and microvessel density as compared to the SMMC-7721/RV control when transplanted in nude mice. smmc 10-14 interleukin 17F Mus musculus 23-29 20819646-6 2010 METHODS: The affinity of GR in hepatic cytosols and in the cytosols of SMMC-7721 cells were determined by radioligand binding assay and scatchard plot. smmc 71-75 nuclear receptor subfamily 3 group C member 1 Homo sapiens 25-27 19302982-5 2009 Our data suggest that activated c-Src played a critical role in the HBx-induced EMT of SMMC-7721 cells. smmc 87-91 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 32-37 20214740-4 2010 AIMS: To (i) assess the expression of DLK1 in human HCC and adjacent liver tissues and human HCC cell lines; (ii) evaluate the effect of DLK1 on SMMC-7721, Huh7 HCC cell growth in vitro and in vivo; and (iii) explore the potential mechanism of DLK1 that regulates HCC cell growth. smmc 145-149 delta like non-canonical Notch ligand 1 Homo sapiens 137-141 20214740-4 2010 AIMS: To (i) assess the expression of DLK1 in human HCC and adjacent liver tissues and human HCC cell lines; (ii) evaluate the effect of DLK1 on SMMC-7721, Huh7 HCC cell growth in vitro and in vivo; and (iii) explore the potential mechanism of DLK1 that regulates HCC cell growth. smmc 145-149 delta like non-canonical Notch ligand 1 Homo sapiens 137-141 20556578-2 2010 HSP70 oligonucleotide was transfected into SMMC-7721 cells by the mediation of Sofast transfection reagent. smmc 43-47 heat shock protein family A (Hsp70) member 4 Homo sapiens 0-5 19522660-3 2010 In vitro assays indicated that a higher uptake of insulin-modified sterically stabilized liposomes (ISSLs) was observed in SMMC-7721 hepatocarcinoma cells overexpressing insulin receptors. smmc 123-127 insulin Homo sapiens 50-57 19666410-6 2009 RESULTS: PLC/PRF/5 and SMMC-7721 expressed IL-20R1; BEL-7402, Hep3B, HepG2, and PLC/PRF/5 expressed IL-20R2; and HepG2 and PLC/PRF/5 expressed IL-22R. smmc 23-27 interleukin 20 receptor subunit alpha Homo sapiens 43-50 20021944-11 2009 The caspase-3 positivity of SMMC-7721 cells treated with thalidomide was increasing along with the increase of treatment time or drug concentration, but not in the control cells. smmc 28-32 caspase 3 Homo sapiens 4-13 19302982-5 2009 Our data suggest that activated c-Src played a critical role in the HBx-induced EMT of SMMC-7721 cells. smmc 87-91 X protein Hepatitis B virus 68-71 19399937-4 2009 We inhibited DNMT1 using siRNA and detected the effect of depletion of DNMT1 on cell proliferation ability and cell apoptosis in the HCC cell line SMMC-7721. smmc 147-151 DNA methyltransferase 1 Homo sapiens 71-76 19403028-1 2009 OBJECTIVE: To study focal adhesion kinase (FAK) expression in hypoxia-stressed SMMC-7721 cells and the role of FAK expression in the hypoxia-induced invasion of SMMC-7721 cells. smmc 79-83 protein tyrosine kinase 2 Homo sapiens 20-41 19403028-1 2009 OBJECTIVE: To study focal adhesion kinase (FAK) expression in hypoxia-stressed SMMC-7721 cells and the role of FAK expression in the hypoxia-induced invasion of SMMC-7721 cells. smmc 79-83 protein tyrosine kinase 2 Homo sapiens 43-46 19403028-1 2009 OBJECTIVE: To study focal adhesion kinase (FAK) expression in hypoxia-stressed SMMC-7721 cells and the role of FAK expression in the hypoxia-induced invasion of SMMC-7721 cells. smmc 161-165 protein tyrosine kinase 2 Homo sapiens 111-114 19403028-7 2009 RESULTS: The expression of FAK was increased significantly in SMMC-7721 cells 24 h after hypoxia stress (P<0.01). smmc 62-66 protein tyrosine kinase 2 Homo sapiens 27-30 19403028-10 2009 However, the migration and invasion of SMMC-7721 cells transfected with pshRNA-FAK was decreased in 1% O2 (P<0.05). smmc 39-43 protein tyrosine kinase 2 Homo sapiens 79-82 19399937-11 2009 Depletion of DNMT1 mediates growth suppression in SMMC-7721 cells. smmc 50-54 DNA methyltransferase 1 Homo sapiens 13-18 18642790-12 2008 MTT method showed that 72 hours after the transfection of h/TRAIL and s/TRAIL the survival rates of the SMMC-7721, BEL-7402, and HepG2 cells all decreased, however, the survival rate of the Hep3B cells and PHHs did not changed significantly. smmc 104-108 TNF superfamily member 10 Homo sapiens 60-65 19118033-5 2009 Transient expression of integrin beta(3) in SMMC-7721 resulted in an enhanced level of apoptosis and suppression of colony formation. smmc 44-48 integrin subunit beta 3 Homo sapiens 24-40 19118033-8 2009 Replenishing these ligands to the starved SMMC-7721 stable transfectants effectively restored the proapoptotic function of integrin beta(3). smmc 42-46 integrin subunit beta 3 Homo sapiens 123-139 18847500-10 2008 si-CD147 also blocked SMMC-7721 cells adhesion to collagen IV and phosphorylation level of SAPK/JNKs. smmc 22-26 basigin (Ok blood group) Homo sapiens 0-8 18847500-10 2008 si-CD147 also blocked SMMC-7721 cells adhesion to collagen IV and phosphorylation level of SAPK/JNKs. smmc 22-26 mitogen-activated protein kinase 9 Homo sapiens 91-95 18299278-10 2008 In vivo experiments showed that adenovirus AdH1-siRNA/CIAPIN1 inhibited the tumorigenicity of SMMC-7721 cells and significantly suppressed tumor growth when injected directly into tumors. smmc 94-98 alcohol dehydrogenase 1A (class I), alpha polypeptide Homo sapiens 43-47 18299278-10 2008 In vivo experiments showed that adenovirus AdH1-siRNA/CIAPIN1 inhibited the tumorigenicity of SMMC-7721 cells and significantly suppressed tumor growth when injected directly into tumors. smmc 94-98 cytokine induced apoptosis inhibitor 1 Homo sapiens 54-61 18752748-0 2008 [Effect of human granulysin on apoptosis, mitochondrial transmembrane potential and cytochrome C release of SMMC-7721 cells]. smmc 108-112 granulysin Homo sapiens 17-27 18247328-2 2008 In this article, we demonstrated that lithium arrested hepatocellular carcinoma cell SMMC-7721 at G2/M checkpoint by inducing the phosphorylation of cdc2 (Tyr-15). smmc 85-89 cyclin dependent kinase 1 Homo sapiens 149-153 19024520-9 2008 Pretreatment of SMMC-7721 cells with IFN-alpha 10000 U/ml for 24 h caused a substantial stabilization of TP mRNA, with a half-live of 35.8 h, compared with 8.5 hr in the control SMMC-7721 cells. smmc 16-20 interferon alpha 1 Homo sapiens 37-46 19024520-9 2008 Pretreatment of SMMC-7721 cells with IFN-alpha 10000 U/ml for 24 h caused a substantial stabilization of TP mRNA, with a half-live of 35.8 h, compared with 8.5 hr in the control SMMC-7721 cells. smmc 16-20 thymidine phosphorylase Homo sapiens 105-107 19024520-9 2008 Pretreatment of SMMC-7721 cells with IFN-alpha 10000 U/ml for 24 h caused a substantial stabilization of TP mRNA, with a half-live of 35.8 h, compared with 8.5 hr in the control SMMC-7721 cells. smmc 178-182 interferon alpha 1 Homo sapiens 37-46 19024520-9 2008 Pretreatment of SMMC-7721 cells with IFN-alpha 10000 U/ml for 24 h caused a substantial stabilization of TP mRNA, with a half-live of 35.8 h, compared with 8.5 hr in the control SMMC-7721 cells. smmc 178-182 thymidine phosphorylase Homo sapiens 105-107 18423123-8 2008 RESULTS: The positive rate of DR5 on SMMC-7721 cells was 95.0%. smmc 37-41 TNF receptor superfamily member 10b Homo sapiens 30-33 27994704-7 2008 RESULTS: Our results show that 9 genes were found to be over expressed by more than two-fold induced by DNMT1 siRNA and 5-Aza-CdR, and 30 genes were found to be over expressed by more than two-fold induced by DNMT3B siRNA and 5-Aza-CdR in SMMC-7721. smmc 239-243 DNA methyltransferase 3 beta Homo sapiens 209-215 27994704-9 2008 The DNMT3B siRNA could induce more genes identical to demethylation agent in SMMC-7721. smmc 77-81 DNA methyltransferase 3 beta Homo sapiens 4-10 18622748-3 2008 Adenovirus-mediated gene transfer of KAI1 (Ad-KAI1) downregulates the SphK1 expression and suppresses the HGF-induced migration of SMMC-7721 human hepatocellcular carcinoma cells. smmc 131-135 CD82 molecule Homo sapiens 37-41 18622748-3 2008 Adenovirus-mediated gene transfer of KAI1 (Ad-KAI1) downregulates the SphK1 expression and suppresses the HGF-induced migration of SMMC-7721 human hepatocellcular carcinoma cells. smmc 131-135 CD82 molecule Homo sapiens 43-50 18622748-3 2008 Adenovirus-mediated gene transfer of KAI1 (Ad-KAI1) downregulates the SphK1 expression and suppresses the HGF-induced migration of SMMC-7721 human hepatocellcular carcinoma cells. smmc 131-135 hepatocyte growth factor Homo sapiens 106-109 18642790-12 2008 MTT method showed that 72 hours after the transfection of h/TRAIL and s/TRAIL the survival rates of the SMMC-7721, BEL-7402, and HepG2 cells all decreased, however, the survival rate of the Hep3B cells and PHHs did not changed significantly. smmc 104-108 TNF superfamily member 10 Homo sapiens 72-77 18237468-7 2008 Hoechst 33342 staining and flow cytometry analysis showed an increase of apoptosis rate and decrease of mitochondrial membrane potential after SMMC-7721 cells were exposed to TBIDOM for 24 h. Pretreatment of SMMC-7721 cells with TBIDOM significantly induced a decrease of Bcl-2 protein expression and an increase of caspase-3 activity and Bax protein expression. smmc 208-212 BCL2 apoptosis regulator Homo sapiens 272-277 18630514-10 2008 The transfection with antisense oligodeoxynucleotides of TCTP led to decreased proliferation of SMMC-7721 cells resulting in cell cycle arrest and pro-apoptosis. smmc 96-100 tumor protein, translationally-controlled 1 Homo sapiens 57-61 18158998-5 2007 RESULTS: siRNA transfection significantly inhibited the expression of NF-kappaB P65 in SMMC-7721cells, with inhibition rates of 64.74% compared with the untreated cells and of 34.52% compared with the liposome-treated cells. smmc 87-91 RELA proto-oncogene, NF-kB subunit Homo sapiens 70-83 17996122-4 2007 METHODS: This study investigated changes in mTOR pathway and telomerase activity in hepatocarcinoma cell line SMMC-7721 treated with chemotherapeutic agent 5-fluorouracil (5-Fu). smmc 110-114 mechanistic target of rapamycin kinase Homo sapiens 44-48 17996122-7 2007 RESULTS: Treating SMMC-7721 cells with 5-Fu leads to apoptosis of the cells, and reduction in telomerase activity, as well as a dramatic reduction in the activated form of p70 S6 kinase, a mTOR substrate. smmc 18-22 mechanistic target of rapamycin kinase Homo sapiens 189-193 18237468-7 2008 Hoechst 33342 staining and flow cytometry analysis showed an increase of apoptosis rate and decrease of mitochondrial membrane potential after SMMC-7721 cells were exposed to TBIDOM for 24 h. Pretreatment of SMMC-7721 cells with TBIDOM significantly induced a decrease of Bcl-2 protein expression and an increase of caspase-3 activity and Bax protein expression. smmc 208-212 caspase 3 Homo sapiens 316-325 18237468-7 2008 Hoechst 33342 staining and flow cytometry analysis showed an increase of apoptosis rate and decrease of mitochondrial membrane potential after SMMC-7721 cells were exposed to TBIDOM for 24 h. Pretreatment of SMMC-7721 cells with TBIDOM significantly induced a decrease of Bcl-2 protein expression and an increase of caspase-3 activity and Bax protein expression. smmc 208-212 BCL2 associated X, apoptosis regulator Homo sapiens 339-342 17407140-0 2007 Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway. smmc 89-93 integrin subunit beta 1 Homo sapiens 18-32 17407140-0 2007 Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway. smmc 89-93 S-phase kinase associated protein 2 Homo sapiens 118-122 17557191-1 2007 Previous study indicated that beta1,4-galactosyltransferase I (beta1,4GT1) was up-regulated by cycloheximide (CHX) and thus enhanced apoptosis induced by CHX in SMMC-7721 cells. smmc 161-165 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 63-73 17928927-9 2007 The growth inhibitory ratio of the purified BL-derived and RG-derived His-LKB1 on hepatic carcinoma SMMC-7721 cells was 24.97% and 45.68%, respectively, and both could produce significant cell-cycle arrest. smmc 100-104 serine/threonine kinase 11 Homo sapiens 74-78 17557191-2 2007 In this study, we reported that constitutively active Akt protein (myr-Akt) inhibited CHX-induced apoptosis in SMMC-7721 cells through down-regulating beta1,4GT1. smmc 111-115 AKT serine/threonine kinase 1 Homo sapiens 54-57 17557191-2 2007 In this study, we reported that constitutively active Akt protein (myr-Akt) inhibited CHX-induced apoptosis in SMMC-7721 cells through down-regulating beta1,4GT1. smmc 111-115 AKT serine/threonine kinase 1 Homo sapiens 71-74 17557191-2 2007 In this study, we reported that constitutively active Akt protein (myr-Akt) inhibited CHX-induced apoptosis in SMMC-7721 cells through down-regulating beta1,4GT1. smmc 111-115 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 151-161 18036325-8 2007 Annexin II was expressed on the membrane of the hepatocellular carcinoma cells of the line SMMC-7721, and 1 microl and 4 microl of annexin II caused the binding rate of beta(2)GPI-GFP with SMMC-7721 cells from 15.58% to 13.66% and 7.56% respectively. smmc 91-95 annexin A2 Homo sapiens 0-10 18036325-8 2007 Annexin II was expressed on the membrane of the hepatocellular carcinoma cells of the line SMMC-7721, and 1 microl and 4 microl of annexin II caused the binding rate of beta(2)GPI-GFP with SMMC-7721 cells from 15.58% to 13.66% and 7.56% respectively. smmc 91-95 apolipoprotein H Homo sapiens 169-179 18036325-8 2007 Annexin II was expressed on the membrane of the hepatocellular carcinoma cells of the line SMMC-7721, and 1 microl and 4 microl of annexin II caused the binding rate of beta(2)GPI-GFP with SMMC-7721 cells from 15.58% to 13.66% and 7.56% respectively. smmc 189-193 annexin A2 Homo sapiens 0-10 18036325-8 2007 Annexin II was expressed on the membrane of the hepatocellular carcinoma cells of the line SMMC-7721, and 1 microl and 4 microl of annexin II caused the binding rate of beta(2)GPI-GFP with SMMC-7721 cells from 15.58% to 13.66% and 7.56% respectively. smmc 189-193 annexin A2 Homo sapiens 131-141 18036325-8 2007 Annexin II was expressed on the membrane of the hepatocellular carcinoma cells of the line SMMC-7721, and 1 microl and 4 microl of annexin II caused the binding rate of beta(2)GPI-GFP with SMMC-7721 cells from 15.58% to 13.66% and 7.56% respectively. smmc 189-193 apolipoprotein H Homo sapiens 169-179 17444856-4 2007 Wild-type RASSF1A cDNA was introduced into SMMC-7721; chemosensitivity to cisplatin, mitomycin and fluorouracil were analyzed using 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide assay. smmc 43-47 Ras association domain family member 1 Homo sapiens 10-17 17988526-0 2007 [Interferon alpha enhances the sensitivity of SMMC-7721 hepatocellular carcinoma cells to 5"-deoxy-5-fluorouridine related to up-regulation of thymidine phosphorylase]. smmc 46-50 thymidine phosphorylase Homo sapiens 143-166 17988526-7 2007 IFN-alpha enhanced the sensitivity of SMMC-7721 cells to 5"-dFUrd with dose-dependent increase. smmc 38-42 interferon alpha 1 Homo sapiens 0-9 17988526-12 2007 CONCLUSION: IFN-alpha enhanced cytotoxicity of 5"-dFUrd against SMMC-7721 cells positively related to its induction of TP mRNA. smmc 64-68 interferon alpha 1 Homo sapiens 12-21 17988526-12 2007 CONCLUSION: IFN-alpha enhanced cytotoxicity of 5"-dFUrd against SMMC-7721 cells positively related to its induction of TP mRNA. smmc 64-68 thymidine phosphorylase Homo sapiens 119-121 17659677-0 2007 The receptor for beta(2)GP I on membrane of hepatocellular carcinoma cell line SMMC-7721 is annexin II. smmc 79-83 apolipoprotein H Homo sapiens 17-28 17659677-0 2007 The receptor for beta(2)GP I on membrane of hepatocellular carcinoma cell line SMMC-7721 is annexin II. smmc 79-83 annexin A2 Homo sapiens 92-102 17659677-4 2007 RT-PCR was used to amplify annexin II, and flow cytometry was used to study the competitive binding of annexin II with beta(2)GP I to SMMC-7721. smmc 134-138 annexin A2 Homo sapiens 103-113 17659677-4 2007 RT-PCR was used to amplify annexin II, and flow cytometry was used to study the competitive binding of annexin II with beta(2)GP I to SMMC-7721. smmc 134-138 apolipoprotein H Homo sapiens 119-130 17659677-7 2007 Annexin II was expressed on the membrane of SMMC-7721, and could compete with beta(2)GP I for combining with SMMC-7721. smmc 44-48 annexin A2 Homo sapiens 0-10 17659677-7 2007 Annexin II was expressed on the membrane of SMMC-7721, and could compete with beta(2)GP I for combining with SMMC-7721. smmc 109-113 annexin A2 Homo sapiens 0-10 17659677-7 2007 Annexin II was expressed on the membrane of SMMC-7721, and could compete with beta(2)GP I for combining with SMMC-7721. smmc 109-113 apolipoprotein H Homo sapiens 78-89 16786197-1 2006 Our previous studies have shown that overexpression of beta1,4-galactosyltransferase1 (beta1,4GT1) leads to increased apoptosis induced by cycloheximide (CHX) in SMMC-7721 human hepatocarcinoma cells. smmc 162-166 beta-1,4-galactosyltransferase 1 Homo sapiens 55-85 17627414-4 2007 We demonstrated that AdVGFP/IL-24 treatment of SMMC-7721 cells in vitro significantly induced HCC cell cytotoxicity and apoptosis, and altered HCC cell cycling with an S-phase reduction and G2/M phase arrest, compared with AdVGFP, without IL-24 expresssion (p < 0.05). smmc 47-51 interleukin 24 Homo sapiens 28-33 17627414-4 2007 We demonstrated that AdVGFP/IL-24 treatment of SMMC-7721 cells in vitro significantly induced HCC cell cytotoxicity and apoptosis, and altered HCC cell cycling with an S-phase reduction and G2/M phase arrest, compared with AdVGFP, without IL-24 expresssion (p < 0.05). smmc 47-51 interleukin 24 Homo sapiens 239-244 17627414-5 2007 Furthermore, we also showed that the treatment of SMMC-7721 tumors by an intratumoral injection of AdVGFP/IL-24 significantly suppressed in vivo HCC growth in athymic nude mice, compared with AdVGFP treatment (p < 0.05). smmc 50-54 interleukin 24 Homo sapiens 106-111 16786197-1 2006 Our previous studies have shown that overexpression of beta1,4-galactosyltransferase1 (beta1,4GT1) leads to increased apoptosis induced by cycloheximide (CHX) in SMMC-7721 human hepatocarcinoma cells. smmc 162-166 beta-1,4-galactosyltransferase 1 Homo sapiens 87-97 16088946-6 2005 Cell-cycle analysis showed G2/M phase arrest in SMMC-7721 cells transfected with TrxR antisense plasmid. smmc 48-52 peroxiredoxin 5 Homo sapiens 81-85 16792868-8 2006 For example, apoptosis rates were increased from 3.5% to 5.2% in HepG2 cells and from 4.8% to 7.9% in SMMC-7721 cells after hTERT RNAi treatment. smmc 102-106 telomerase reverse transcriptase Homo sapiens 124-129 16792868-9 2006 Apoptosis rates were increased from 5.3% to 10.4% in HepG 2 cells and from 13.9% to 77.2% in SMMC-7721 cells after being treated by 100 ng/ml TRAIL for 24 h. However, there were no remarkable changes between control cells and untransformed cells. smmc 93-97 TNF superfamily member 10 Homo sapiens 142-147 16635299-0 2006 [Effect of hydroxycamptothecin on apoptosis-inducing factor (AIF) expression and on AIF translocation in human hepatocellular cancer cell SMMC-7721]. smmc 138-142 apoptosis inducing factor mitochondria associated 1 Homo sapiens 84-87 16911943-10 2006 CTL induced by the mDC group had a significant killing response to SMMC-7721 as well as a higher killing rate for L-02 (P>0.05). smmc 67-71 chemokine (C-C motif) ligand 22 Mus musculus 19-22 16911943-11 2006 CTL induced by mDC and imDC together had a higher killing response to SMMC-7721, but a lower killing rate for L-02 (P<0.01). smmc 70-74 chemokine (C-C motif) ligand 22 Mus musculus 15-18 16406609-3 2006 Here, we report that two structurally distinct PI3K inhibitors, wortmannin and LY294002, inhibited insulin-induced activation of ERK1/2 but had no effect on EGF-induced activation of ERK1/2 in hepatocellular carcinoma BEL-7402 and SMMC-7721 cells, breast cancer MCF-7 cells, and prostate cancer LNCaP cells. smmc 231-235 insulin Homo sapiens 99-106 16406609-3 2006 Here, we report that two structurally distinct PI3K inhibitors, wortmannin and LY294002, inhibited insulin-induced activation of ERK1/2 but had no effect on EGF-induced activation of ERK1/2 in hepatocellular carcinoma BEL-7402 and SMMC-7721 cells, breast cancer MCF-7 cells, and prostate cancer LNCaP cells. smmc 231-235 mitogen-activated protein kinase 3 Homo sapiens 129-135 16405841-10 2005 RESULTS: The TP mRNA expression of the SMMC-7721 cells induced by IFN-alpha of the doses of 5000 U/ml and 10,000 U/ml significantly increased in comparison with the un-treated SMMC-7721 cells (0 U/ml, P < 0.05). smmc 39-43 interferon alpha 1 Homo sapiens 66-75 16419156-0 2005 Overexpression of cyclooxygenase-2 in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell lines and mechanism of cyclooxygenase-2 selective inhibitor celecoxib-induced cell growth inhibition and apoptosis. smmc 64-68 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-34 15553829-3 2004 RESULTS: ATI could significantly inhibit SMMC-7721 cell movement and migration on FN, adhesion with FN and EC, also could lower CD44 and MMP-2 in cancer cells. smmc 41-45 fibronectin 1 Homo sapiens 82-84 15544062-8 2004 HEM 30 microM significantly decreased Bcl-2 protein expression to 58.7% in SMMC-7721 and to 57.6% in HO-8910 cells. smmc 75-79 BCL2 apoptosis regulator Homo sapiens 38-43 15544062-9 2004 While HCPT 0.5 microM significantly decreased Bcl-2 protein expression to 64.3% in SMMC-7721 and to 70.0% in HO-8910 cells. smmc 83-87 BCL2 apoptosis regulator Homo sapiens 46-51 15544062-10 2004 HEM 25 microM and 30 microM significantly increased P53 protein expression 2.3-3.6-fold in SMMC-7721 and 3.0-5.7- fold in HO-8910 cells. smmc 91-95 tumor protein p53 Homo sapiens 52-55 16109531-6 2005 RESULTS: In vitro, after 24, 48, 72 hours the inhibitory rate of proliferation of SMMC-7721 cells treated with EGFR antisense-odn was 8%, 32%, and 34% respectively. smmc 82-86 epidermal growth factor receptor Homo sapiens 111-115 15864645-8 2005 CONCLUSION: Sensitivity to 5"-dFUrd could be enhanced by transfection with TP cDNA for SMMC-7721 cells. smmc 87-91 thymidine phosphorylase Homo sapiens 75-77 15949399-13 2005 The apoptotic rates of SMMC-7721 cells under no serum condition transfected with HBx and HBx3"-40, especially the former, were 12.57% and 9.15%, significantly higher than that of the pcDNA3HBx group. smmc 23-27 X protein Hepatitis B virus 81-84 15301707-0 2004 [Induction of differentiation by ginsenoside Rh2 in hepatocarcinoma cell SMMC-7721]. smmc 73-77 Rh associated glycoprotein Homo sapiens 45-48 15300888-3 2004 The effect of leptin on proliferation of Chang liver cell line and liver cancer cell line SMMC-7721 was studied with cell proliferation assay (MTT). smmc 90-94 leptin Homo sapiens 14-20 15301707-5 2004 This study was to investigate the induced differentiative effects of G-Rh2 on SMMC-7721 hepatocarcinoma cells. smmc 78-82 Rh associated glycoprotein Homo sapiens 71-74 15301707-11 2004 RESULTS: G-Rh2 inhibited the proliferation of SMMC-7721 cells in dose and time-dependent manners. smmc 46-50 Rh associated glycoprotein Homo sapiens 11-14 15301707-13 2004 Twenty microg/ml G-Rh2 induced the mature and normality of morphology and ultrastructure in SMMC-7721 cells. smmc 92-96 Rh associated glycoprotein Homo sapiens 19-22 15301707-15 2004 CONCLUSION: G-Rh2 could induce the SMMC-7721 cell differentiation tending to normal. smmc 35-39 Rh associated glycoprotein Homo sapiens 14-17 15254713-6 2004 The CD80-transfected cell line was also found able to activate T cells which subsequently induced cell lysis of SMMC-7721, QGY-7703 and parent BEL-7402 cell lines as detected by cytotoxicity assay. smmc 112-116 CD80 molecule Homo sapiens 4-8 15133846-15 2004 CONCLUSION: Angiostatin cDNA could be stably expressed in human hepatocellular carcinoma cell line SMMC-7721 without obvious inhibitory effects on the growth of SMMC-7721 cells. smmc 99-103 plasminogen Mus musculus 12-23 15532706-10 2004 Transient expression of the PTEN gene in SMMC-7721 and HepG2 hepatoma cells resulted in decreased FAK phosphorylation. smmc 41-45 phosphatase and tensin homolog Homo sapiens 28-32 15532706-10 2004 Transient expression of the PTEN gene in SMMC-7721 and HepG2 hepatoma cells resulted in decreased FAK phosphorylation. smmc 41-45 protein tyrosine kinase 2 Homo sapiens 98-101 12951046-4 2003 Flow cytometry analysis showed that apoptosis was inhibited in Gag-PKB transfected SMMC-7721 cells. smmc 83-87 AKT serine/threonine kinase 1 Homo sapiens 67-70 14675461-0 2003 In vitro induction of differentiation by ginsenoside Rh2 in SMMC-7721 hepatocarcinoma cell line. smmc 60-64 Rh associated glycoprotein Homo sapiens 53-56 14636445-1 2003 OBJECTIVE: To observe the anti-tumor effect of combination TNF-related apoptosis-inducing ligand (TRAIL) with aspirin on liver cancer cell line, SMMC-7721. smmc 145-149 TNF superfamily member 10 Homo sapiens 59-96 14636445-1 2003 OBJECTIVE: To observe the anti-tumor effect of combination TNF-related apoptosis-inducing ligand (TRAIL) with aspirin on liver cancer cell line, SMMC-7721. smmc 145-149 TNF superfamily member 10 Homo sapiens 98-103 14636445-3 2003 RESULTS: The survival fraction of SMMC-7721 cells treated with 300 ng/ml TRAIL, 3 mmol/L or 10 mmol/L aspirin alone was 82.76%, 81.34% and 71.29% respectively, and the survival fractions of SMMC-7721 cells treated with TRAIL and 3 mmol/L or 10 mmol/L aspirin were 43.54% and 37.8% respectively. smmc 34-38 TNF superfamily member 10 Homo sapiens 73-78 14636445-3 2003 RESULTS: The survival fraction of SMMC-7721 cells treated with 300 ng/ml TRAIL, 3 mmol/L or 10 mmol/L aspirin alone was 82.76%, 81.34% and 71.29% respectively, and the survival fractions of SMMC-7721 cells treated with TRAIL and 3 mmol/L or 10 mmol/L aspirin were 43.54% and 37.8% respectively. smmc 190-194 TNF superfamily member 10 Homo sapiens 73-78 14636445-4 2003 The apoptosis rates of SMMC-7721 cells induced by TRAIL and 3 mmol/L or 10 mmol/L aspirin were higher than that induced by TRAIL or aspirin alone (34.76% and 38.56% vs 21.25%, 1.89% and 6.08%), and G0/G1 arrest was observed under TRAIL and aspirin. smmc 23-27 TNF superfamily member 10 Homo sapiens 50-61 14636445-4 2003 The apoptosis rates of SMMC-7721 cells induced by TRAIL and 3 mmol/L or 10 mmol/L aspirin were higher than that induced by TRAIL or aspirin alone (34.76% and 38.56% vs 21.25%, 1.89% and 6.08%), and G0/G1 arrest was observed under TRAIL and aspirin. smmc 23-27 TNF superfamily member 10 Homo sapiens 50-55 14636445-5 2003 The expression of Bcl-2 in SMMC-7721 cells treated by 3 mmol/L or 10 mmol/L aspirin decreased markedly, but no effect on Bax. smmc 27-31 BCL2 apoptosis regulator Homo sapiens 18-23 14690556-1 2003 OBJECTIVE: To observe the sensitivity change of SMMC-7721 cells transfected with antisense DNMT1 gene fragment to tumor necrosis factor related apoptosis inducing ligand (TRAIL) and its mechanism. smmc 48-52 DNA methyltransferase 1 Homo sapiens 91-96 14690556-1 2003 OBJECTIVE: To observe the sensitivity change of SMMC-7721 cells transfected with antisense DNMT1 gene fragment to tumor necrosis factor related apoptosis inducing ligand (TRAIL) and its mechanism. smmc 48-52 TNF superfamily member 10 Homo sapiens 114-169 14690556-1 2003 OBJECTIVE: To observe the sensitivity change of SMMC-7721 cells transfected with antisense DNMT1 gene fragment to tumor necrosis factor related apoptosis inducing ligand (TRAIL) and its mechanism. smmc 48-52 TNF superfamily member 10 Homo sapiens 171-176 14966912-8 2004 The apoptotic rate of hepatocarcinoma SMMC-7721 cells was significantly promoted (17.98+/-0.86% vs 4.86+/-0.27%, P<0.01) and the survival rate was notably decreased (80.99+/-3.20% vs 93.52+/-3.93%, P<0.05) due to antisense VEGF(165) by flow cytometry (FCM). smmc 38-42 vascular endothelial growth factor A Homo sapiens 229-233 14980107-2 2004 METHODS: SMMC-7721/ADM was transfected with synthetic antisense phosphorothioate oligonucleotides complementary to gene MDR1 and MRP mediated by Lipofectamine. smmc 9-13 ATP binding cassette subfamily B member 1 Homo sapiens 120-124 14980107-2 2004 METHODS: SMMC-7721/ADM was transfected with synthetic antisense phosphorothioate oligonucleotides complementary to gene MDR1 and MRP mediated by Lipofectamine. smmc 9-13 ATP binding cassette subfamily C member 1 Homo sapiens 129-132 14980107-4 2004 RESULTS: ASODN of MDR1+MRP increased the sensitivity of SMMC-7721/ADM to chemotherapeutic drug more significantly than that any of MDR1 and MRP did separately. smmc 56-60 ATP binding cassette subfamily B member 1 Homo sapiens 18-22 14980107-4 2004 RESULTS: ASODN of MDR1+MRP increased the sensitivity of SMMC-7721/ADM to chemotherapeutic drug more significantly than that any of MDR1 and MRP did separately. smmc 56-60 ATP binding cassette subfamily C member 1 Homo sapiens 23-26 14575563-2 2003 METHODS: Two plasmids including pIRES-EGFP-HBx and pTK-Hyg were co-transfected to a hepatocellular carcinoma cell line SMMC-7721. smmc 119-123 protein tyrosine kinase 2 beta Homo sapiens 51-54 12970919-8 2003 CONCLUSION: Telomerase activity and Caspase-3 expression are changed in human hepatocellular carcinoma cell line SMMC-7721 treated with all-trans retinioc acid. smmc 113-117 caspase 3 Homo sapiens 36-45 12046075-9 2002 CONCLUSION: The selective COX-2 inhibitor, Nimesulide can inhibit the proliferation of SMMC-7721 cells and increase apoptosis rate and apoptosis index of SMMC-7721 cells. smmc 87-91 prostaglandin-endoperoxide synthase 2 Homo sapiens 26-31 12918102-5 2003 RESULTS: Overexpression of alpha5beta1 or beta1 integrin induced S-phase delay in SMMC-7721 cells, and this delay was possibly due to the accumulation of cyclin-dependent kinase inhibitors (CKIs) p21(cip1) and p27(kip1). smmc 82-86 integrin subunit beta 1 Homo sapiens 42-56 12439923-0 2002 Over-expression of LPTS-L in hepatocellular carcinoma cell line SMMC-7721 induces crisis. smmc 64-68 PIN2 (TERF1) interacting telomerase inhibitor 1 Homo sapiens 19-23 12609084-10 2002 The endostatin-transfected SMMC-endo cells had similar in vitro growth rates to SMMC-pLncx cells. smmc 27-31 collagen type XVIII alpha 1 chain Homo sapiens 4-14 11833073-7 2002 Significant differences of both Cx32 and Cx43 protein expression existed between hepatocellular carcinoma cell lines and normal liver cell line (P=0.0069, HHCC vs QZG; P=0.0087, SMMC-7721 vs QZG). smmc 178-182 gap junction protein alpha 1 Homo sapiens 41-45 11833073-8 2002 Moreover, the fluorescent intensities of Cx32 and Cx43 proteins in HHCC, SMMC-7721 were lower than that in QZG. smmc 73-77 gap junction protein beta 1 Homo sapiens 41-45 11833073-8 2002 Moreover, the fluorescent intensities of Cx32 and Cx43 proteins in HHCC, SMMC-7721 were lower than that in QZG. smmc 73-77 gap junction protein alpha 1 Homo sapiens 50-54 11502212-3 2001 In this study, we have shown that the human hepatocellular carcinoma cell line, SMMC-7721, was insensitive to TNF-alpha cytotoxicity and underwent apoptosis quickly in the presence of TNF-alpha and Chx. smmc 80-84 tumor necrosis factor Homo sapiens 184-193 11783016-4 2001 RESULTS: SMMC-7721 expressed much more FAK than did hepatocyte line L02. smmc 9-13 protein tyrosine kinase 2 Homo sapiens 39-42 12053189-4 2001 It was shown that the SMMC-7721 cells were insensitive to TNF-alpha cytotoxicity, but they entered apoptosis quickly in the presence of cycloheximide and TNF-alpha. smmc 22-26 tumor necrosis factor Homo sapiens 154-163 11819727-0 2001 Reduction of tumorigenicity of SMMC-7721 hepatoma cells by vascular endothelial growth factor antisense gene therapy. smmc 31-35 vascular endothelial growth factor A Homo sapiens 59-93 12053189-7 2001 When FAK was 60% reduced as a result of the transfection of SMMC-7721 cells with FAK antisense construct, the percentage of TNF-alpha/cycloheximide-induced apoptosis was enhanced at lower dose of TNF-alpha but decreased at higher dose of TNF-alpha, compared with the control. smmc 60-64 protein tyrosine kinase 2 Homo sapiens 5-8 12053189-7 2001 When FAK was 60% reduced as a result of the transfection of SMMC-7721 cells with FAK antisense construct, the percentage of TNF-alpha/cycloheximide-induced apoptosis was enhanced at lower dose of TNF-alpha but decreased at higher dose of TNF-alpha, compared with the control. smmc 60-64 protein tyrosine kinase 2 Homo sapiens 81-84 12053189-7 2001 When FAK was 60% reduced as a result of the transfection of SMMC-7721 cells with FAK antisense construct, the percentage of TNF-alpha/cycloheximide-induced apoptosis was enhanced at lower dose of TNF-alpha but decreased at higher dose of TNF-alpha, compared with the control. smmc 60-64 tumor necrosis factor Homo sapiens 124-133 12053189-7 2001 When FAK was 60% reduced as a result of the transfection of SMMC-7721 cells with FAK antisense construct, the percentage of TNF-alpha/cycloheximide-induced apoptosis was enhanced at lower dose of TNF-alpha but decreased at higher dose of TNF-alpha, compared with the control. smmc 60-64 tumor necrosis factor Homo sapiens 196-205 12053189-7 2001 When FAK was 60% reduced as a result of the transfection of SMMC-7721 cells with FAK antisense construct, the percentage of TNF-alpha/cycloheximide-induced apoptosis was enhanced at lower dose of TNF-alpha but decreased at higher dose of TNF-alpha, compared with the control. smmc 60-64 tumor necrosis factor Homo sapiens 196-205 12549072-5 2000 It suggested that TGF-beta 1 rapidly regulated the activation of integrin, and stimulated FAK dephosphorylation, which might induce depolarization in SMMC-7721 hepatocellular carcinoma cells, then facilitates the detachment of tumor cells at early stages of migration. smmc 150-154 transforming growth factor beta 1 Homo sapiens 18-28 12053189-0 2001 Role of FAK in TNF-alpha/Cycloheximide-induced Apoptosis of SMMC-7721 Cells. smmc 60-64 protein tyrosine kinase 2 Homo sapiens 8-11 12053189-0 2001 Role of FAK in TNF-alpha/Cycloheximide-induced Apoptosis of SMMC-7721 Cells. smmc 60-64 tumor necrosis factor Homo sapiens 15-24 11135695-5 2000 One hour predisposed MTT trial in control with parental antibody HAb25 affirmed that hscFv25-TNFalpha was cytotoxic to targeted cell SMMC-7721 with the IC(50) to be 7.1 microg/ml. smmc 133-137 tumor necrosis factor Mus musculus 93-101 12549072-5 2000 It suggested that TGF-beta 1 rapidly regulated the activation of integrin, and stimulated FAK dephosphorylation, which might induce depolarization in SMMC-7721 hepatocellular carcinoma cells, then facilitates the detachment of tumor cells at early stages of migration. smmc 150-154 protein tyrosine kinase 2 Homo sapiens 90-93 9206084-4 1996 RESULTS: TS at low doses (0.005-0.1 mg.L-1), with dose dependence, was able to kill SMMC-7721, SGC-7901 and HeLa cells. smmc 84-88 immunoglobulin kappa variable 1-16 Homo sapiens 39-42 10366986-4 1999 The effect of IGF-II antisense RNA which was expressed by pIGF-II As on SMMC-7721 cell cycles progression was measured with FCM. smmc 72-76 insulin like growth factor 2 Homo sapiens 14-20 9206084-5 1996 IC50 values for SMMC-7721, SGC-7901 and HeLa cells were 0.007, 0.011 and 0.018 mg.L-1 by trypan blue dye exclusion test and 0.016, 0.055 and 0.078 mg.L-1 by neutral red vital staining test. smmc 16-20 immunoglobulin kappa variable 1-16 Homo sapiens 82-85 9206084-5 1996 IC50 values for SMMC-7721, SGC-7901 and HeLa cells were 0.007, 0.011 and 0.018 mg.L-1 by trypan blue dye exclusion test and 0.016, 0.055 and 0.078 mg.L-1 by neutral red vital staining test. smmc 16-20 immunoglobulin kappa variable 1-16 Homo sapiens 150-153 2588913-1 1989 Using radioligand binding assay, the presence of epidermal growth factor (EGF) receptors in cells of two human liver cancer cell lines, BEL-7402 and SMMC-7721, was demonstrated. smmc 149-153 epidermal growth factor Homo sapiens 49-72 2588913-1 1989 Using radioligand binding assay, the presence of epidermal growth factor (EGF) receptors in cells of two human liver cancer cell lines, BEL-7402 and SMMC-7721, was demonstrated. smmc 149-153 epidermal growth factor Homo sapiens 74-77 33928346-4 2021 In this study, we evaluated the effect of TSLC1-armed oncolytic adenovirus (S24-TSLC1) on the Wnt/beta-catenin pathway, cell viability, invasion and migration abilities of HCC in vitro and the growth of SMMC-7721-xenografted tumor in mice model. smmc 203-207 cell adhesion molecule 1 Mus musculus 42-47