PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31051433-0	2019	A natural anticancer pigment,Pheophytin a,from a seagrass acts as a high affinity human mitochondrial translocator protein (TSPO) ligand, in silico, to reduce mitochondrial membrane Potential ( psimit) in adenocarcinomic A549 cells.	pheophytin a	29-41	translocator protein	Homo sapiens	124-128
16592382-4	1977	In contrast, lasing was observed for both the (0,0) and (0,1) vibronic regions of the S(1) --> S(0) fluorescence band of pheophytin a and methyl pheophorbide a.	pheophytin a	124-136	proteasome 26S subunit, non-ATPase 1	Homo sapiens	86-90
31051433-7	2019	CONCLUSION: Hence Pheophytin a could be seen as a possible TSPO ligand for targeting metastatic alveolar cancers like A549 via intrinsic apoptotic pathway.	pheophytin a	18-30	translocator protein	Homo sapiens	59-63
18046491-4	2007	Significant inhibition of the survival of HuH-7 cells (<10%) was observed when an irradiation dose of 10.2 J cm(-2) combined with the concentration of 0.5 microg ml(-1) of phe a, 0.125 microg ml(-1) of pho a, 0.25 microg ml(-1) of phe b, and 0.125 microg ml(-1) of pho b were applied.	pheophytin a	175-180	MIR7-3 host gene	Homo sapiens	42-47
25501336-0	2014	Pheophytin a inhibits inflammation via suppression of LPS-induced nitric oxide synthase-2, prostaglandin E2, and interleukin-1beta of macrophages.	pheophytin a	0-12	nitric oxide synthase 2	Homo sapiens	66-89
25501336-0	2014	Pheophytin a inhibits inflammation via suppression of LPS-induced nitric oxide synthase-2, prostaglandin E2, and interleukin-1beta of macrophages.	pheophytin a	0-12	interleukin 1 beta	Homo sapiens	113-130
25501336-4	2014	We found that pre-treatment with pheophytin a suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin-1beta in RAW 264.7 macrophages.	pheophytin a	33-45	interleukin 1 beta	Homo sapiens	138-155
25501336-5	2014	NO synthase-2 (NOS2) and cyclooxygenase-2 (COX-2) expression levels were repressed by pre-treatment with pheophytin a at both the transcriptional and translational levels.	pheophytin a	105-117	nitric oxide synthase 2	Homo sapiens	0-13
25501336-5	2014	NO synthase-2 (NOS2) and cyclooxygenase-2 (COX-2) expression levels were repressed by pre-treatment with pheophytin a at both the transcriptional and translational levels.	pheophytin a	105-117	nitric oxide synthase 2	Homo sapiens	15-19
25501336-5	2014	NO synthase-2 (NOS2) and cyclooxygenase-2 (COX-2) expression levels were repressed by pre-treatment with pheophytin a at both the transcriptional and translational levels.	pheophytin a	105-117	prostaglandin-endoperoxide synthase 2	Homo sapiens	25-41
25501336-5	2014	NO synthase-2 (NOS2) and cyclooxygenase-2 (COX-2) expression levels were repressed by pre-treatment with pheophytin a at both the transcriptional and translational levels.	pheophytin a	105-117	prostaglandin-endoperoxide synthase 2	Homo sapiens	43-48
25501336-6	2014	Pheophytin a inhibited NOS2 promoter activity, but not its mRNA stability, through extracellular signal-regulated kinase (ERK1/2).	pheophytin a	0-12	nitric oxide synthase 2	Homo sapiens	23-27
25501336-6	2014	Pheophytin a inhibited NOS2 promoter activity, but not its mRNA stability, through extracellular signal-regulated kinase (ERK1/2).	pheophytin a	0-12	mitogen-activated protein kinase 3	Homo sapiens	122-128
25501336-8	2014	Pheophytin a reduced signal transducers and activators of transcription 1 (STAT-1) activation, without an obvious influence on activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB).	pheophytin a	0-12	signal transducer and activator of transcription 1	Homo sapiens	21-73
25501336-8	2014	Pheophytin a reduced signal transducers and activators of transcription 1 (STAT-1) activation, without an obvious influence on activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB).	pheophytin a	0-12	signal transducer and activator of transcription 1	Homo sapiens	75-81
25501336-9	2014	These results suggest that pheophytin a functions by down-regulating the transcriptional levels of inflammatory mediators and blocking the ERK and STAT-1 pathways.	pheophytin a	27-39	mitogen-activated protein kinase 1	Homo sapiens	139-142
25501336-9	2014	These results suggest that pheophytin a functions by down-regulating the transcriptional levels of inflammatory mediators and blocking the ERK and STAT-1 pathways.	pheophytin a	27-39	signal transducer and activator of transcription 1	Homo sapiens	147-153
23402855-7	2013	These results indicate that pheophorbide a and pheophytin a are two important candidates of S. japonica as anti-inflammatory agents which can inhibit the production of NO via inhibition of iNOS protein expression.	pheophytin a	47-59	nitric oxide synthase 2, inducible	Mus musculus	189-193
19450556-5	2009	Computational modeling revealed that pheophytin a can bind to the active site of HCV-NS3, suggesting that NS3 is a potent molecular target of pheophytin a.	pheophytin a	37-49	KRAS proto-oncogene, GTPase	Homo sapiens	85-88
19450556-5	2009	Computational modeling revealed that pheophytin a can bind to the active site of HCV-NS3, suggesting that NS3 is a potent molecular target of pheophytin a.	pheophytin a	37-49	KRAS proto-oncogene, GTPase	Homo sapiens	106-109
19450556-5	2009	Computational modeling revealed that pheophytin a can bind to the active site of HCV-NS3, suggesting that NS3 is a potent molecular target of pheophytin a.	pheophytin a	142-154	KRAS proto-oncogene, GTPase	Homo sapiens	85-88
19450556-5	2009	Computational modeling revealed that pheophytin a can bind to the active site of HCV-NS3, suggesting that NS3 is a potent molecular target of pheophytin a.	pheophytin a	142-154	KRAS proto-oncogene, GTPase	Homo sapiens	106-109
19450556-6	2009	Biochemical analysis further revealed that pheophytin a inhibited NS3 serine protease activity with IC(50)=0.89 microM.	pheophytin a	43-55	KRAS proto-oncogene, GTPase	Homo sapiens	66-69
19450556-8	2009	This study thereby demonstrates for the first time that pheophytin a is a potent HCV-NS3 protease inhibitor and offers insight for development of novel anti-HCV regimens.	pheophytin a	56-68	KRAS proto-oncogene, GTPase	Homo sapiens	85-88
28096189-2	2017	Pheophytinase (PPH) is the enzyme for catalyzing the removal of the phytol group from pheophytin a, and PPH expression is significantly induced during leaf senescence.	pheophytin a	86-98	pheophytinase	Arabidopsis thaliana	0-13
28096189-2	2017	Pheophytinase (PPH) is the enzyme for catalyzing the removal of the phytol group from pheophytin a, and PPH expression is significantly induced during leaf senescence.	pheophytin a	86-98	pheophytinase	Arabidopsis thaliana	15-18
24189419-0	2013	Pheophytin a and chlorophyll a identified from environmentally friendly cultivation of green pepper enhance interleukin-2 and interferon-gamma in Peyer"s patches ex vivo.	pheophytin a	0-12	interleukin 2	Homo sapiens	108-121
24189419-0	2013	Pheophytin a and chlorophyll a identified from environmentally friendly cultivation of green pepper enhance interleukin-2 and interferon-gamma in Peyer"s patches ex vivo.	pheophytin a	0-12	interferon gamma	Homo sapiens	126-142
24189419-6	2013	Intake of pheophytin a and chlorophyll a significantly increased IL-2 and IFN-gamma production, and the percentage of IL-2- and IFN-gamma-producing CD4+ T-cells in PP.	pheophytin a	10-22	interleukin 2	Homo sapiens	65-69
24189419-6	2013	Intake of pheophytin a and chlorophyll a significantly increased IL-2 and IFN-gamma production, and the percentage of IL-2- and IFN-gamma-producing CD4+ T-cells in PP.	pheophytin a	10-22	interferon gamma	Homo sapiens	74-83
24189419-6	2013	Intake of pheophytin a and chlorophyll a significantly increased IL-2 and IFN-gamma production, and the percentage of IL-2- and IFN-gamma-producing CD4+ T-cells in PP.	pheophytin a	10-22	interleukin 2	Homo sapiens	118-137
18046491-8	2007	Our findings demonstrate that both apoptosis and necrosis can be induced in HuH-7 cells after PDT using phe a, phe b, pho a and pho b and LEDs.	pheophytin a	104-109	MIR7-3 host gene	Homo sapiens	76-81
12809498-8	2003	WSCP binds Chl a, Chl b, bacteriochlorophyll a, and the Zn derivative of Chl a but not pheophytin a, indicating that the central metal ion in Chl is essential for binding.	pheophytin a	87-99	kunitz-type trypsin inhibitor-like 1 protein	Brassica oleracea	0-4
9719465-6	1998	(3) Pheophytin a and b from green tea showed inhibitory effects against early induction of ornithine decarboxylase (ODC) in BALB/c mouse skin fibroblasts caused by TPA.	pheophytin a	4-16	ornithine decarboxylase, structural 1	Mus musculus	91-114
9719465-6	1998	(3) Pheophytin a and b from green tea showed inhibitory effects against early induction of ornithine decarboxylase (ODC) in BALB/c mouse skin fibroblasts caused by TPA.	pheophytin a	4-16	ornithine decarboxylase, structural 1	Mus musculus	116-119
9467755-8	1997	Pheophytin a caused a suppressive effect against formyl-Met-Leu-Phe, (FMLP)-induced chemotaxis of human polymorphonuclear leukocytes (PMNs) in Boyden"s chamber experiment.	pheophytin a	0-12	formyl peptide receptor 1	Homo sapiens	70-74