PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26568264-3	2015	Here we report that three gustatory receptors, GR8a, GR66a and GR98b function together in the detection of L-canavanine, a plant-derived insecticide.	Canavanine	107-119	Gustatory receptor 8a	Drosophila melanogaster	47-51
28699234-7	2017	Interestingly, the effects of increased insulin secretion by morin and canavanine were markedly reduced in Si-NISCH cells.	Canavanine	71-81	nischarin	Mus musculus	110-115
28536076-6	2017	Here in this study we focus on the inhibitory effects of polyarginine and its analogues polyornithine, canavanine, and citrulline on the inhibition of p53 mutant peptide aggregation, and p53 mutant cancer cell proliferation inhibition in vitro.	Canavanine	103-113	tumor protein p53	Homo sapiens	151-154
28536076-6	2017	Here in this study we focus on the inhibitory effects of polyarginine and its analogues polyornithine, canavanine, and citrulline on the inhibition of p53 mutant peptide aggregation, and p53 mutant cancer cell proliferation inhibition in vitro.	Canavanine	103-113	tumor protein p53	Homo sapiens	187-190
28334887-4	2017	Strains lacking Apn1, Apn2, Ntg1, Ntg2 or Rev3 displayed wild-type frequencies of APOBEC3B-induced canavanine resistance (CanR).	Canavanine	99-109	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	16-20
28334887-4	2017	Strains lacking Apn1, Apn2, Ntg1, Ntg2 or Rev3 displayed wild-type frequencies of APOBEC3B-induced canavanine resistance (CanR).	Canavanine	99-109	DNA-directed DNA polymerase	Saccharomyces cerevisiae S288C	42-46
26839743-1	2016	The non-protein amino acid L-canavanine (L-CAV), an antimetabolite of L-arginine (L-ARG), can alter the 3D conformation of proteins when incorporated into a protein instead of L-ARG.	Canavanine	27-39	caveolin 2	Homo sapiens	43-46
26568264-3	2015	Here we report that three gustatory receptors, GR8a, GR66a and GR98b function together in the detection of L-canavanine, a plant-derived insecticide.	Canavanine	107-119	Gustatory receptor 66a	Drosophila melanogaster	53-58
26568264-3	2015	Here we report that three gustatory receptors, GR8a, GR66a and GR98b function together in the detection of L-canavanine, a plant-derived insecticide.	Canavanine	107-119	Gustatory receptor 98b	Drosophila melanogaster	63-68
26568264-4	2015	Ectopic co-expression of Gr8a and Gr98b in Gr66a-expressing, bitter-sensing gustatory receptor neurons (GRNs) confers responsiveness to L-canavanine.	Canavanine	136-148	Gustatory receptor 8a	Drosophila melanogaster	25-29
26568264-4	2015	Ectopic co-expression of Gr8a and Gr98b in Gr66a-expressing, bitter-sensing gustatory receptor neurons (GRNs) confers responsiveness to L-canavanine.	Canavanine	136-148	Gustatory receptor 98b	Drosophila melanogaster	34-39
26568264-4	2015	Ectopic co-expression of Gr8a and Gr98b in Gr66a-expressing, bitter-sensing gustatory receptor neurons (GRNs) confers responsiveness to L-canavanine.	Canavanine	136-148	Gustatory receptor 66a	Drosophila melanogaster	43-48
26568264-5	2015	Furthermore, misexpression of all three Grs enables salt- or sweet-sensing GRNs to respond to L-canavanine.	Canavanine	94-106	Glycyl-tRNA synthetase	Drosophila melanogaster	40-43
26568264-6	2015	Introduction of these Grs in sweet-sensing GRNs switches L-canavanine from an aversive to an attractive compound.	Canavanine	57-69	Glycyl-tRNA synthetase	Drosophila melanogaster	22-25
26568264-7	2015	Co-expression of GR8a, GR66a and GR98b in Drosophila S2 cells induces an L-canavanine-activated nonselective cation conductance.	Canavanine	73-85	Gustatory receptor 8a	Drosophila melanogaster	17-21
26568264-7	2015	Co-expression of GR8a, GR66a and GR98b in Drosophila S2 cells induces an L-canavanine-activated nonselective cation conductance.	Canavanine	73-85	Gustatory receptor 66a	Drosophila melanogaster	23-28
26568264-7	2015	Co-expression of GR8a, GR66a and GR98b in Drosophila S2 cells induces an L-canavanine-activated nonselective cation conductance.	Canavanine	73-85	Gustatory receptor 98b	Drosophila melanogaster	33-38
23624824-4	2013	L-canavanine, a selective iNOS inhibitor, partly blocked CoCl2-induced cytotoxicity, apoptosis and mitochondrial insult.	Canavanine	0-12	nitric oxide synthase 2	Rattus norvegicus	26-30
25482045-9	2015	In addition, canavanine increased calcium influx into NISCH-CHO-K1 cells in a manner similar to agmatine, the endogenous ligand of imidazoline receptors.	Canavanine	13-23	nischarin	Rattus norvegicus	54-59
24777576-4	2014	To explore whether alpha-synuclein oligomerization was associated with S-nitrosylation of PDI, we made the rat brain slice model of manganism and pretreated slices with L-Canavanine, a selective iNOS inhibitor.	Canavanine	169-181	nitric oxide synthase 2	Rattus norvegicus	195-199
24777576-11	2014	The results showed that L-Canavanine pretreatment could reduce Mn-induced nerve cell injury and alpha-synuclein oligomerization.	Canavanine	24-36	synuclein alpha	Rattus norvegicus	96-111
24777576-12	2014	Additionally, there was a significant recovery in PDI activity in L-Canavanine-pretreated slices.	Canavanine	66-78	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	50-53
26192192-8	2015	Additionally, the canavanine-stimulated AMPK phosphorylation and glucose transporter (GLUT4) expression were also sensitive to BU224 inhibition in the C2 C12 cells.	Canavanine	18-28	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	86-91
26199284-4	2015	The utility of this approach was demonstrated via the identification of the known CAN1 and TOP1 resistance targets for two compounds, canavanine and camptothecin, respectively.	Canavanine	134-144	arginine permease CAN1	Saccharomyces cerevisiae S288C	82-86
29082273-3	2014	The CAN1 gene encodes for an arginine permease that is responsible for the uptake of arginine and it can also transport the toxic analog of arginine, canavanine (Whelan et al., 1979).	Canavanine	150-160	arginine permease CAN1	Saccharomyces cerevisiae S288C	4-8
29082273-4	2014	When CAN1 cells are grown on a media containing canavanine but lacking arginine, the cells die because of the uptake of the toxic canavanine.	Canavanine	48-58	arginine permease CAN1	Saccharomyces cerevisiae S288C	5-9
24859084-3	2014	Here, we determined the crystal structures of the apo, L-arginine-complexed, and L-canavanine-complexed forms of the cytoplasmic free isoform of human ArgRS (hArgRS).	Canavanine	81-93	arginyl-tRNA synthetase 1	Homo sapiens	151-156
24876389-4	2014	Overexpression of arn1(+) confers canavanine resistance on cells, whereas its disruption causes hypersensitivity to canavanine.	Canavanine	34-44	siderophore transporter	Saccharomyces cerevisiae S288C	18-22
23671680-0	2013	Galphao is required for L-canavanine detection in Drosophila.	Canavanine	24-36	G protein alpha o subunit	Drosophila melanogaster	0-7
23671680-4	2013	L-canavanine is a ligand of DmXR, a variant G-protein coupled receptor (GPCR) belonging to the metabotropic glutamate receptor subfamily that is expressed in bitter-sensitive taste neurons of Drosophila.	Canavanine	0-12	mangetout	Drosophila melanogaster	28-32
23671680-4	2013	L-canavanine is a ligand of DmXR, a variant G-protein coupled receptor (GPCR) belonging to the metabotropic glutamate receptor subfamily that is expressed in bitter-sensitive taste neurons of Drosophila.	Canavanine	0-12	Trapped in endoderm 1	Drosophila melanogaster	44-70
23671680-4	2013	L-canavanine is a ligand of DmXR, a variant G-protein coupled receptor (GPCR) belonging to the metabotropic glutamate receptor subfamily that is expressed in bitter-sensitive taste neurons of Drosophila.	Canavanine	0-12	Trapped in endoderm 1	Drosophila melanogaster	72-76
23671680-6	2013	The aim of this study was to identify which Galpha protein was required for L-canavanine detection in Drosophila.	Canavanine	76-88	G protein alpha q subunit	Drosophila melanogaster	44-50
23671680-8	2013	Then, by using genetic, behavioral assays and electrophysiology, we found that Galphao47A is required in bitter-sensitive taste neurons for L-canavanine sensitivity.	Canavanine	140-152	G protein alpha o subunit	Drosophila melanogaster	79-89
23671680-9	2013	In conclusion, our study revealed that Galphao47A plays a crucial role in L-canavanine detection.	Canavanine	74-86	G protein alpha o subunit	Drosophila melanogaster	39-49
22279227-5	2012	Here, we showed that GRs are essential for responding to L-canavanine and that flies missing DmXR displayed normal L-canavanine avoidance and L-canavanine-evoked action potentials.	Canavanine	115-127	mangetout	Drosophila melanogaster	93-97
23169667-5	2012	Heterologous expression of PQLC2 at the yeast vacuole rescues the resistance phenotype of an ypq2 mutant to canavanine, a toxic analog of arginine efficiently transported by PQLC2.	Canavanine	108-118	solute carrier family 66 member 1	Homo sapiens	27-32
23169667-5	2012	Heterologous expression of PQLC2 at the yeast vacuole rescues the resistance phenotype of an ypq2 mutant to canavanine, a toxic analog of arginine efficiently transported by PQLC2.	Canavanine	108-118	Ypq2p	Saccharomyces cerevisiae S288C	93-97
23169667-5	2012	Heterologous expression of PQLC2 at the yeast vacuole rescues the resistance phenotype of an ypq2 mutant to canavanine, a toxic analog of arginine efficiently transported by PQLC2.	Canavanine	108-118	solute carrier family 66 member 1	Homo sapiens	174-179
22279227-5	2012	Here, we showed that GRs are essential for responding to L-canavanine and that flies missing DmXR displayed normal L-canavanine avoidance and L-canavanine-evoked action potentials.	Canavanine	115-127	mangetout	Drosophila melanogaster	93-97
22279227-7	2012	We found that L-canavanine stimulated action potentials in S-type sensilla, which were where Gr8a and Gr66a were both expressed, but not in Gr66a-expressing sensilla that did not express Gr8a.	Canavanine	14-26	Gustatory receptor 8a	Drosophila melanogaster	93-97
22279227-7	2012	We found that L-canavanine stimulated action potentials in S-type sensilla, which were where Gr8a and Gr66a were both expressed, but not in Gr66a-expressing sensilla that did not express Gr8a.	Canavanine	14-26	Gustatory receptor 66a	Drosophila melanogaster	102-107
22279227-9	2012	Gr8a was narrowly required for responding to L-canavanine, in contrast to Gr66a, which was broadly required for responding to other noxious tastants.	Canavanine	45-57	Gustatory receptor 8a	Drosophila melanogaster	0-4
22279227-10	2012	Our data suggest that GR8a and GR66a are subunits of an L-canavanine receptor and that GR8a contributes to the specificity for L-canavanine.	Canavanine	56-68	Gustatory receptor 8a	Drosophila melanogaster	22-26
22279227-10	2012	Our data suggest that GR8a and GR66a are subunits of an L-canavanine receptor and that GR8a contributes to the specificity for L-canavanine.	Canavanine	56-68	Gustatory receptor 66a	Drosophila melanogaster	31-36
21786666-4	2011	However, this mutation significantly increases the frequency of spontaneous canavanine-resistance mutations induced by disturbances in correcting errors of DNA replication and repair, which distinguishes it from all identified alleles of gene MEC1.	Canavanine	76-86	protein kinase MEC1	Saccharomyces cerevisiae S288C	243-247
22279227-4	2012	In addition to GRs, a G protein-coupled receptor, DmXR, has been reported to be required for detecting L-canavanine.	Canavanine	103-115	mangetout	Drosophila melanogaster	50-54
19139279-6	2009	In support of this idea, growth of Saccharomyces cerevisiae in the presence of the arginine analog canavanine results in increased SUMOylation and Slx5-Slx8-mediated degradation of wild-type Mot1.	Canavanine	99-109	SUMO-targeted ubiquitin ligase complex subunit SLX5	Saccharomyces cerevisiae S288C	147-151
19564899-11	2009	Blockade of DmXR function with an antagonist lowers the repulsive effect of L-canavanine.	Canavanine	76-88	mangetout	Drosophila melanogaster	12-16
19564899-12	2009	In addition, disruption of the DmXR encoding gene, called mangetout (mtt), suppresses the L-canavanine repellent effect.	Canavanine	90-102	mangetout	Drosophila melanogaster	31-35
19564899-13	2009	To avoid the ingestion of L-canavanine, DmXR expression is required in bitter-sensitive gustatory receptor neurons, where it triggers the premature retraction of the proboscis, thus leading to the end of food searching.	Canavanine	26-38	mangetout	Drosophila melanogaster	40-44
19139279-6	2009	In support of this idea, growth of Saccharomyces cerevisiae in the presence of the arginine analog canavanine results in increased SUMOylation and Slx5-Slx8-mediated degradation of wild-type Mot1.	Canavanine	99-109	SUMO-targeted ubiquitin ligase complex subunit SLX8	Saccharomyces cerevisiae S288C	152-156
19139279-6	2009	In support of this idea, growth of Saccharomyces cerevisiae in the presence of the arginine analog canavanine results in increased SUMOylation and Slx5-Slx8-mediated degradation of wild-type Mot1.	Canavanine	99-109	DNA-binding ATPase	Saccharomyces cerevisiae S288C	191-195
18776715-7	2008	In diploid cells treated with 500 microM of 1-nitropyrene, the frequency with which can1Delta::LEU2/can1Delta::LEU2 was converted from CAN1/can1Delta::LEU2, a phenotypic change from a canavanine-sensitive to canavanine-resistant form, was 8.59 x 10(-4), which is 9.15-fold higher than the spontaneous level.	Canavanine	208-218	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	95-99
18776715-7	2008	In diploid cells treated with 500 microM of 1-nitropyrene, the frequency with which can1Delta::LEU2/can1Delta::LEU2 was converted from CAN1/can1Delta::LEU2, a phenotypic change from a canavanine-sensitive to canavanine-resistant form, was 8.59 x 10(-4), which is 9.15-fold higher than the spontaneous level.	Canavanine	184-194	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	95-99
18776715-7	2008	In diploid cells treated with 500 microM of 1-nitropyrene, the frequency with which can1Delta::LEU2/can1Delta::LEU2 was converted from CAN1/can1Delta::LEU2, a phenotypic change from a canavanine-sensitive to canavanine-resistant form, was 8.59 x 10(-4), which is 9.15-fold higher than the spontaneous level.	Canavanine	184-194	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	111-115
18776715-7	2008	In diploid cells treated with 500 microM of 1-nitropyrene, the frequency with which can1Delta::LEU2/can1Delta::LEU2 was converted from CAN1/can1Delta::LEU2, a phenotypic change from a canavanine-sensitive to canavanine-resistant form, was 8.59 x 10(-4), which is 9.15-fold higher than the spontaneous level.	Canavanine	184-194	arginine permease CAN1	Saccharomyces cerevisiae S288C	135-139
18776715-7	2008	In diploid cells treated with 500 microM of 1-nitropyrene, the frequency with which can1Delta::LEU2/can1Delta::LEU2 was converted from CAN1/can1Delta::LEU2, a phenotypic change from a canavanine-sensitive to canavanine-resistant form, was 8.59 x 10(-4), which is 9.15-fold higher than the spontaneous level.	Canavanine	184-194	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	111-115
18776715-7	2008	In diploid cells treated with 500 microM of 1-nitropyrene, the frequency with which can1Delta::LEU2/can1Delta::LEU2 was converted from CAN1/can1Delta::LEU2, a phenotypic change from a canavanine-sensitive to canavanine-resistant form, was 8.59 x 10(-4), which is 9.15-fold higher than the spontaneous level.	Canavanine	208-218	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	111-115
18776715-7	2008	In diploid cells treated with 500 microM of 1-nitropyrene, the frequency with which can1Delta::LEU2/can1Delta::LEU2 was converted from CAN1/can1Delta::LEU2, a phenotypic change from a canavanine-sensitive to canavanine-resistant form, was 8.59 x 10(-4), which is 9.15-fold higher than the spontaneous level.	Canavanine	208-218	arginine permease CAN1	Saccharomyces cerevisiae S288C	135-139
18776715-7	2008	In diploid cells treated with 500 microM of 1-nitropyrene, the frequency with which can1Delta::LEU2/can1Delta::LEU2 was converted from CAN1/can1Delta::LEU2, a phenotypic change from a canavanine-sensitive to canavanine-resistant form, was 8.59 x 10(-4), which is 9.15-fold higher than the spontaneous level.	Canavanine	208-218	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	111-115
16492753-1	2006	The fidelity of yeast RNA polymerase II (Pol II) was assessed in vivo with an assay in which errors in transcription of can1-100, a nonsense allele of CAN1, result in enhanced sensitivity to the toxic arginine analog canavanine.	Canavanine	217-227	arginine permease CAN1	Saccharomyces cerevisiae S288C	120-124
17560946-5	2007	When thapsigargin-treated cells were pre-treated with iNOS inhibitors 1400W or L-canavanine, their ER stress-induced oxidative stress was almost totally abolished.	Canavanine	79-91	nitric oxide synthase 2, inducible	Mus musculus	54-58
16492753-1	2006	The fidelity of yeast RNA polymerase II (Pol II) was assessed in vivo with an assay in which errors in transcription of can1-100, a nonsense allele of CAN1, result in enhanced sensitivity to the toxic arginine analog canavanine.	Canavanine	217-227	arginine permease CAN1	Saccharomyces cerevisiae S288C	151-155
16149916-6	2006	Secondly, the dss1 mutant showed phenotypes indicative of a defect in proteasome function: growth of the dss1 mutant was inhibited by low concentrations of L-canavanine, an amino acid analogue, and cells of the dss1 mutant accumulated high molecular mass poly-ubiquitylated proteins.	Canavanine	156-168	SEM1 26S proteasome subunit	Homo sapiens	14-18
16149916-6	2006	Secondly, the dss1 mutant showed phenotypes indicative of a defect in proteasome function: growth of the dss1 mutant was inhibited by low concentrations of L-canavanine, an amino acid analogue, and cells of the dss1 mutant accumulated high molecular mass poly-ubiquitylated proteins.	Canavanine	156-168	SEM1 26S proteasome subunit	Homo sapiens	105-109
16149916-6	2006	Secondly, the dss1 mutant showed phenotypes indicative of a defect in proteasome function: growth of the dss1 mutant was inhibited by low concentrations of L-canavanine, an amino acid analogue, and cells of the dss1 mutant accumulated high molecular mass poly-ubiquitylated proteins.	Canavanine	156-168	SEM1 26S proteasome subunit	Homo sapiens	105-109
16553303-1	2006	Activity of tubular lysosomic (N-acetyl-beta-D-glucosaminidase--NAG, its thermostable isoenzyme NAG B and B-galactosidase--beta-GAL) and mitochondrial (L-canavanine: ornithine amidinetransferase--COAT) enzymes were measured in urine of 30 patients with diabetes complicated by diabetic nephropathy (DN).	Canavanine	152-164	N-acetyl-alpha-glucosaminidase	Homo sapiens	64-67
15077884-8	2004	As compared with the control group, L-canavanine significantly reduced serum levels of amylase and lipase, the severity of pancreatic edema and necrosis, and the volume of ascites in 5 hours.	Canavanine	36-48	lipase G, endothelial type	Rattus norvegicus	99-105
15716093-7	2005	The growth of upf1Delta, can1-100 cells is inhibited by canavanine.	Canavanine	56-66	arginine permease CAN1	Saccharomyces cerevisiae S288C	25-29
15716093-8	2005	The deletion of NUP100 allows upf1Delta, can1-100 cells to grow in the presence of canavanine.	Canavanine	83-93	FG-nucleoporin NUP100	Saccharomyces cerevisiae S288C	16-22
15716093-8	2005	The deletion of NUP100 allows upf1Delta, can1-100 cells to grow in the presence of canavanine.	Canavanine	83-93	arginine permease CAN1	Saccharomyces cerevisiae S288C	41-45
15329499-2	2004	Saccharomyces cerevisiae rad27Delta mutants further display a repeat tract instability phenotype and a high rate of forward mutations to canavanine resistance that result from duplications of DNA sequence, indicating a role in mutation avoidance.	Canavanine	137-147	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	25-30
15987637-4	2005	Furthermore, expression of AtUBP6 restored canavanine resistance to the Deltaubp6 yeast mutant.	Canavanine	43-53	ubiquitin-specific protease 6	Arabidopsis thaliana	27-33
12482876-6	2003	The levels of SUMO1 and -2 conjugates but not SUMO3 conjugates increased substantially following exposure of seedlings to stress conditions, including heat shock, H(2)O(2), ethanol, and the amino acid analog canavanine.	Canavanine	208-218	small ubiquitin-like modifier 1	Arabidopsis thaliana	14-26
12095698-5	2002	Upon formation of a deletion over the active CAN1-CYH2 genes, a cell becomes resistant to both canavanine and cycloheximide.	Canavanine	95-105	arginine permease CAN1	Saccharomyces cerevisiae S288C	45-49
12456008-6	2002	btn2delta strains, like rsg1delta strains, are sensitive for growth in the presence of the arginine analog canavanine.	Canavanine	107-117	Btn2p	Saccharomyces cerevisiae S288C	0-4
12150944-0	2002	Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL.	Canavanine	24-36	caspase 3	Homo sapiens	94-103
12150944-0	2002	Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL.	Canavanine	24-36	BCL2 apoptosis regulator	Homo sapiens	128-133
12150944-0	2002	Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL.	Canavanine	24-36	BCL2 like 1	Homo sapiens	137-143
12150944-3	2002	When Jurkat T cells were treated with 1.25-5.0mM L-canavanine for 36 h, apoptotic cell death accompanying several biochemical events such as caspase-3 activation, degradation of poly(ADP-ribose) polymerase (PARP), and apoptotic DNA fragmentation was induced in a dose-dependent manner; however, cytochrome c release from mitochondria was not detected.	Canavanine	49-61	caspase 3	Homo sapiens	141-150
12150944-3	2002	When Jurkat T cells were treated with 1.25-5.0mM L-canavanine for 36 h, apoptotic cell death accompanying several biochemical events such as caspase-3 activation, degradation of poly(ADP-ribose) polymerase (PARP), and apoptotic DNA fragmentation was induced in a dose-dependent manner; however, cytochrome c release from mitochondria was not detected.	Canavanine	49-61	poly(ADP-ribose) polymerase 1	Homo sapiens	178-205
12150944-3	2002	When Jurkat T cells were treated with 1.25-5.0mM L-canavanine for 36 h, apoptotic cell death accompanying several biochemical events such as caspase-3 activation, degradation of poly(ADP-ribose) polymerase (PARP), and apoptotic DNA fragmentation was induced in a dose-dependent manner; however, cytochrome c release from mitochondria was not detected.	Canavanine	49-61	poly(ADP-ribose) polymerase 1	Homo sapiens	207-211
12150944-3	2002	When Jurkat T cells were treated with 1.25-5.0mM L-canavanine for 36 h, apoptotic cell death accompanying several biochemical events such as caspase-3 activation, degradation of poly(ADP-ribose) polymerase (PARP), and apoptotic DNA fragmentation was induced in a dose-dependent manner; however, cytochrome c release from mitochondria was not detected.	Canavanine	49-61	cytochrome c, somatic	Homo sapiens	295-307
12150944-6	2002	These results demonstrate that the cytotoxic effect of L-canavanine on Jurkat T cells is attributable to the induced apoptosis and that L-canavanine-induced apoptosis is mediated by a cytochrome c-independent caspase-3 activation pathway that can be interrupted by Bcl-2 or Bcl-xL.	Canavanine	136-148	cytochrome c, somatic	Homo sapiens	184-196
12150944-6	2002	These results demonstrate that the cytotoxic effect of L-canavanine on Jurkat T cells is attributable to the induced apoptosis and that L-canavanine-induced apoptosis is mediated by a cytochrome c-independent caspase-3 activation pathway that can be interrupted by Bcl-2 or Bcl-xL.	Canavanine	136-148	caspase 3	Homo sapiens	209-218
12150944-6	2002	These results demonstrate that the cytotoxic effect of L-canavanine on Jurkat T cells is attributable to the induced apoptosis and that L-canavanine-induced apoptosis is mediated by a cytochrome c-independent caspase-3 activation pathway that can be interrupted by Bcl-2 or Bcl-xL.	Canavanine	136-148	BCL2 apoptosis regulator	Homo sapiens	265-270
12150944-6	2002	These results demonstrate that the cytotoxic effect of L-canavanine on Jurkat T cells is attributable to the induced apoptosis and that L-canavanine-induced apoptosis is mediated by a cytochrome c-independent caspase-3 activation pathway that can be interrupted by Bcl-2 or Bcl-xL.	Canavanine	136-148	BCL2 like 1	Homo sapiens	274-280
12701807-2	2003	After 72 h of exposure to L-canavanine, the percentage of cells in the radiosensitive G2/M phase of the cell cycle increased 6-fold in PANC-1 cells and 4-fold in MIA PaCa-2 cells, when compared to untreated cells.	Canavanine	26-38	MIA SH3 domain containing	Homo sapiens	162-165
12701807-6	2003	L-Canavanine was found to be synergistic with radiation when either PANC-1 or MIA PaCa-2 cells were exposed to L-canavanine for 72 h prior to irradiation.	Canavanine	0-12	MIA SH3 domain containing	Homo sapiens	78-81
12239211-8	2002	Induction of HSP42 by AZC treatment required protein synthesis; treatment with ethanol, which can also misfold proteins, activated heat shock factor, but treatment with canavanine, an arginine analog less potent than AZC at misfolding proteins, did not.	Canavanine	169-179	heat shock protein HSP42	Saccharomyces cerevisiae S288C	13-18
12095698-5	2002	Upon formation of a deletion over the active CAN1-CYH2 genes, a cell becomes resistant to both canavanine and cycloheximide.	Canavanine	95-105	ribosomal 60S subunit protein L28	Saccharomyces cerevisiae S288C	50-54
11322632-3	2001	Of these agents, hydralazine and L-canavanine produced a relaxing effect on endothelin-1-contracted muscle that was significantly greater than relaxing effect on carbachol-contracted muscle.	Canavanine	33-45	endothelin 1	Bos taurus	76-88
12064516-4	2002	L-canavanine in a concentration of 3 mM, increased the basal and hyposmosis-induced TRH secretion from the posterior pituitary and the paraventricular nucleus, and both basal and ethanol-induced TRH secretion from isolated pancreatic islets.	Canavanine	0-12	thyrotropin releasing hormone	Homo sapiens	84-87
12064516-4	2002	L-canavanine in a concentration of 3 mM, increased the basal and hyposmosis-induced TRH secretion from the posterior pituitary and the paraventricular nucleus, and both basal and ethanol-induced TRH secretion from isolated pancreatic islets.	Canavanine	0-12	thyrotropin releasing hormone	Homo sapiens	195-198
11598140-3	2001	Cells expressing mutant versions of ubiquitin were found to be sensitive to cadmium, an agent that causes oxidative damage to cellular components, and to canavanine, an amino acid analog that generates misfolded proteins.	Canavanine	154-164	ubiquitin	Saccharomyces cerevisiae S288C	36-45
11598140-4	2001	The greatest sensitivity to canavanine was observed in cells expressing a mutant version of ubiquitin unable to support the formation of Lys(48) linkages.	Canavanine	28-38	ubiquitin	Saccharomyces cerevisiae S288C	92-101
11485568-5	2001	Three of the Type I ligands, S-ethylisothiourea, L-canavanine and 2,5-lutidine, displaced the CO from the haem iron upon addition to the iNOS oxygenase domain.	Canavanine	49-61	nitric oxide synthase 2, inducible	Mus musculus	137-141
11438646-3	2001	rad27Delta mutants display both a repeat tract instability phenotype and a high rate of forward mutations to canavanine resistance that result primarily from duplications of DNA sequences that are flanked by direct repeats.	Canavanine	109-119	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	0-5
11523781-2	2001	The triple mutants rad1 ntg1 ntg2 and rad14 ntg1 ntg2 show 15- and 22-fold increases, respectively, in spontaneous forward mutation to canavanine resistance (CanR) relative to the wild-type strain (WT).	Canavanine	135-145	ssDNA endodeoxyribonuclease RAD1	Saccharomyces cerevisiae S288C	19-23
11523781-2	2001	The triple mutants rad1 ntg1 ntg2 and rad14 ntg1 ntg2 show 15- and 22-fold increases, respectively, in spontaneous forward mutation to canavanine resistance (CanR) relative to the wild-type strain (WT).	Canavanine	135-145	bifunctional N-glycosylase/AP lyase NTG1	Saccharomyces cerevisiae S288C	24-28
11523781-2	2001	The triple mutants rad1 ntg1 ntg2 and rad14 ntg1 ntg2 show 15- and 22-fold increases, respectively, in spontaneous forward mutation to canavanine resistance (CanR) relative to the wild-type strain (WT).	Canavanine	135-145	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	29-33
11523781-2	2001	The triple mutants rad1 ntg1 ntg2 and rad14 ntg1 ntg2 show 15- and 22-fold increases, respectively, in spontaneous forward mutation to canavanine resistance (CanR) relative to the wild-type strain (WT).	Canavanine	135-145	DNA repair protein RAD14	Saccharomyces cerevisiae S288C	38-43
11523781-2	2001	The triple mutants rad1 ntg1 ntg2 and rad14 ntg1 ntg2 show 15- and 22-fold increases, respectively, in spontaneous forward mutation to canavanine resistance (CanR) relative to the wild-type strain (WT).	Canavanine	135-145	bifunctional N-glycosylase/AP lyase NTG1	Saccharomyces cerevisiae S288C	44-48
11523781-2	2001	The triple mutants rad1 ntg1 ntg2 and rad14 ntg1 ntg2 show 15- and 22-fold increases, respectively, in spontaneous forward mutation to canavanine resistance (CanR) relative to the wild-type strain (WT).	Canavanine	135-145	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	49-53
11333222-6	2001	Errors in the repair process can be detected by the production of canavanine-resistant (can1) mutants among the TRP1 recombinants.	Canavanine	66-76	arginine permease CAN1	Saccharomyces cerevisiae S288C	88-92
11333222-6	2001	Errors in the repair process can be detected by the production of canavanine-resistant (can1) mutants among the TRP1 recombinants.	Canavanine	66-76	phosphoribosylanthranilate isomerase TRP1	Saccharomyces cerevisiae S288C	112-116
11847504-4	2002	The depression of contractility by IL-1beta and TNF-alpha was prevented by administration of a nonselective nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) or an inhibitor of inducible nitric oxide synthase, L-canavanine.	Canavanine	237-249	interleukin 1 beta	Rattus norvegicus	35-43
11847504-4	2002	The depression of contractility by IL-1beta and TNF-alpha was prevented by administration of a nonselective nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) or an inhibitor of inducible nitric oxide synthase, L-canavanine.	Canavanine	237-249	tumor necrosis factor	Rattus norvegicus	48-57
11847504-6	2002	These results support current thinking that the depression of myocardial function by IL-1beta and TNF-alpha is mediated, at least in part, by an intracardiac increase in inducible nitric oxide synthase, and that in contrast to L-NAME, the decline in coronary conductance seen in cytokine-treated is not prevented by L-canavanine hearts.	Canavanine	316-328	interleukin 1 beta	Rattus norvegicus	85-93
11847504-6	2002	These results support current thinking that the depression of myocardial function by IL-1beta and TNF-alpha is mediated, at least in part, by an intracardiac increase in inducible nitric oxide synthase, and that in contrast to L-NAME, the decline in coronary conductance seen in cytokine-treated is not prevented by L-canavanine hearts.	Canavanine	316-328	tumor necrosis factor	Rattus norvegicus	98-107
11230720-0	2001	L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin-1 concentrations in dogs with endotoxic shock.	Canavanine	0-12	nitric oxide synthase 2	Canis lupus familiaris	39-60
11230720-0	2001	L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin-1 concentrations in dogs with endotoxic shock.	Canavanine	0-12	endothelin 1	Canis lupus familiaris	79-91
11230720-1	2001	PURPOSE: The purpose of this article is to elucidate the effect of L-canavanine, a selective inhibitor of inducible NO synthase (iNOS), on hemodynamics, blood gas parameters, and plasma concentrations of lactate and endothelin-1 (ET-1) during endotoxic shock.	Canavanine	67-79	nitric oxide synthase 2	Canis lupus familiaris	106-127
11230720-1	2001	PURPOSE: The purpose of this article is to elucidate the effect of L-canavanine, a selective inhibitor of inducible NO synthase (iNOS), on hemodynamics, blood gas parameters, and plasma concentrations of lactate and endothelin-1 (ET-1) during endotoxic shock.	Canavanine	67-79	nitric oxide synthase 2	Canis lupus familiaris	129-133
11230720-1	2001	PURPOSE: The purpose of this article is to elucidate the effect of L-canavanine, a selective inhibitor of inducible NO synthase (iNOS), on hemodynamics, blood gas parameters, and plasma concentrations of lactate and endothelin-1 (ET-1) during endotoxic shock.	Canavanine	67-79	endothelin 1	Canis lupus familiaris	216-228
11230720-1	2001	PURPOSE: The purpose of this article is to elucidate the effect of L-canavanine, a selective inhibitor of inducible NO synthase (iNOS), on hemodynamics, blood gas parameters, and plasma concentrations of lactate and endothelin-1 (ET-1) during endotoxic shock.	Canavanine	67-79	endothelin 1	Canis lupus familiaris	230-234
11230720-7	2001	CONCLUSIONS: This study suggests that L-canavanine induces tissue hypoperfusion and ischemia with concomitant hypersecretion of ET-1 in dogs with endotoxic shock.	Canavanine	38-50	endothelin 1	Canis lupus familiaris	128-132
10077187-3	1999	Here we report an increased frequency of forward mutation to canavanine resistance in mutants defective in the nucleotide excision repair (NER) gene RAD14.	Canavanine	61-71	DNA repair protein RAD14	Saccharomyces cerevisiae S288C	149-154
10669902-1	1999	New MIF-1 (Pro-Leu-Gly-NH2) analogs containing unnatural amino acids such as L-canavanine (Cav) and L-cysteic acid S-(2-aminoethyl)amide (sLys) have been synthesized and in vitro experiments were performed to study their action on neurotransmission in target tissues with adrenergic and cholinergic neurotransmission.	Canavanine	77-89	macrophage migration inhibitory factor	Rattus norvegicus	4-7
10030795-3	1999	The use of L-canavanine, a selective inhibitor of iNOS, might be more suitable.	Canavanine	11-23	nitric oxide synthase 2	Rattus norvegicus	50-54
10030795-14	1999	Considering 31P MRS derived bioenergetic indices, the endotoxin-induced decrease in pHi and Pcr/Pi was attenuated by L-NMMA and corrected by L-canavanine.	Canavanine	141-153	glucose-6-phosphate isomerase	Rattus norvegicus	84-87
10030795-15	1999	In conclusion, in a rodent model of endotoxinic shock, the continuous infusion of L-canavanine, a selective iNOS inhibitor, improved the systemic hemodynamic parameters and the intracellular bio-energetic patterns estimated by in vivo 31P MRS. To the contrary, the continuous infusion of both constitutive and inducible NOS inhibitor L-NMMA was not followed by the same achievement.	Canavanine	82-94	nitric oxide synthase 2	Rattus norvegicus	108-112
11123195-6	2001	These changes in the sphincteric function following LPS may be associated with increase in the inducible NOS (iNOS) expression since they were blocked by iNOS inhibitor L-canavanine.	Canavanine	169-181	nitric oxide synthase 2	Homo sapiens	95-108
11123195-6	2001	These changes in the sphincteric function following LPS may be associated with increase in the inducible NOS (iNOS) expression since they were blocked by iNOS inhibitor L-canavanine.	Canavanine	169-181	nitric oxide synthase 2	Homo sapiens	110-114
11123195-6	2001	These changes in the sphincteric function following LPS may be associated with increase in the inducible NOS (iNOS) expression since they were blocked by iNOS inhibitor L-canavanine.	Canavanine	169-181	nitric oxide synthase 2	Homo sapiens	154-158
11115897-1	2000	AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine.	Canavanine	70-80	ubiquitin-specific protease 1	Arabidopsis thaliana	0-12
11115897-7	2000	From the analysis of T-DNA insertion mutants, we demonstrate that the AtUBP1 and 2 subfamily helps confer resistance to the arginine analog canavanine.	Canavanine	140-150	ubiquitin-specific protease 1	Arabidopsis thaliana	70-82
10753927-0	2000	The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake.	Canavanine	70-80	Ras homolog, mTORC1 binding	Rattus norvegicus	29-33
10471701-7	1999	Although rad23Delta rpn10Delta displays similar sensitivity to DNA damage as a rad23Delta single mutant, deletion of RAD23 in rpn10Delta significantly increased sensitivity to canavanine, a phenotype associated with an rpn10Delta single mutant.	Canavanine	176-186	Rad23p	Saccharomyces cerevisiae S288C	117-122
10211586-2	1999	In macrophages and polymorphonuclear leukocytes, which express inducible nitric oxide synthase (iNOS), L-canavanine is able to prevent the L-arginine-derived synthesis of nitric oxide (NO).	Canavanine	103-115	nitric oxide synthase 2	Homo sapiens	63-94
10211586-2	1999	In macrophages and polymorphonuclear leukocytes, which express inducible nitric oxide synthase (iNOS), L-canavanine is able to prevent the L-arginine-derived synthesis of nitric oxide (NO).	Canavanine	103-115	nitric oxide synthase 2	Homo sapiens	96-100
9539417-4	1998	The hsm3-1 mutation produces a mutator phenotype, enhancing the rates of spontaneous mutation to canavanine resistance and reversions of lys1-1 and his1-7.	Canavanine	97-107	Hsm3p	Saccharomyces cerevisiae S288C	4-8
10076567-0	1999	Growth inhibition of A549 human lung adenocarcinoma cells by L-canavanine is associated with p21/WAF1 induction.	Canavanine	61-73	cyclin dependent kinase inhibitor 1A	Homo sapiens	93-96
10076567-0	1999	Growth inhibition of A549 human lung adenocarcinoma cells by L-canavanine is associated with p21/WAF1 induction.	Canavanine	61-73	cyclin dependent kinase inhibitor 1A	Homo sapiens	97-101
10397478-0	1998	L-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines.	Canavanine	0-12	ATP binding cassette subfamily B member 1	Homo sapiens	61-75
10397478-1	1998	L-Canavanine (L-CAV) is a naturally occurring L-arginine analog that induces the formation of non-functional proteins in a variety of organisms.	Canavanine	0-12	caveolin 2	Homo sapiens	16-19
9154870-2	1997	In the present study, we evaluated the effects of L-canavanine, a selective iNOS inhibitor, in an animal model of septic shock, with a particular focus on tissue oxidative metabolism and organ functions.	Canavanine	50-62	nitric oxide synthase 2	Rattus norvegicus	76-80
9108279-12	1997	When compared to those of a wild-type strain, the frequencies of mutation to canavanine resistance (CanR) and reversion to Lys+ are sevenfold and tenfold higher for the ogg1 mutant strain, respectively.	Canavanine	77-87	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	169-173
9404643-0	1997	Proteolytic profile of recombinant pro-opiomelanocortin in embryonal carcinoma P19 cells: conversion to beta-lipotropin and secretion are inhibited following incubation with canavanine.	Canavanine	174-184	proopiomelanocortin	Homo sapiens	35-55
9404643-8	1997	As for other peptide precursors in endocrine cells, the conversion of POMC in P19 cells was inhibited by the biosynthetic replacement of its arginine residues by the analog canavanine.	Canavanine	173-183	proopiomelanocortin	Homo sapiens	70-74
8852838-2	1996	A can1 cyh2 cell carrying two negative selection markers, the CAN1 and CYH2 genes, on a YCp plasmid is sensitive to canavanine and cycloheximide, but the cell becomes resistant to both drugs when the plasmid has a deletion over the CAN1 and CYH2 genes.	Canavanine	116-126	arginine permease CAN1	Saccharomyces cerevisiae S288C	2-6
8752868-7	1996	Even at the permissive temperature (30 degrees C), the uby1-1 mutant grew somewhat slowly and showed pleiotropic phenotypes including hypersensitivity to stresses such as cadmium and canavanine, and sporulation defects.	Canavanine	183-193	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	55-59
8940060-2	1996	In Escherichia coli, Lon protease is responsible for the rate-limiting step in degradation of highly unstable proteins such as SulA, RcsA, and lambdaN protein, as well as for about 50% of the rapid degradation of abnormal proteins such as canavanine-containing proteins.	Canavanine	239-249	putative ATP-dependent Lon protease	Escherichia coli	21-24
8940060-3	1996	We found that Lon-dependent degradation of both SulA and lambdaN protein was unaffected in cells lacking functional DnaJ, whereas Lon-dependent turnover of canavanine-containing proteins was slower in dnaJ mutant cells.	Canavanine	156-166	putative ATP-dependent Lon protease	Escherichia coli	130-133
8940060-3	1996	We found that Lon-dependent degradation of both SulA and lambdaN protein was unaffected in cells lacking functional DnaJ, whereas Lon-dependent turnover of canavanine-containing proteins was slower in dnaJ mutant cells.	Canavanine	156-166	DnaJ	Escherichia coli	201-205
8852838-2	1996	A can1 cyh2 cell carrying two negative selection markers, the CAN1 and CYH2 genes, on a YCp plasmid is sensitive to canavanine and cycloheximide, but the cell becomes resistant to both drugs when the plasmid has a deletion over the CAN1 and CYH2 genes.	Canavanine	116-126	ribosomal 60S subunit protein L28	Saccharomyces cerevisiae S288C	7-11
8852838-2	1996	A can1 cyh2 cell carrying two negative selection markers, the CAN1 and CYH2 genes, on a YCp plasmid is sensitive to canavanine and cycloheximide, but the cell becomes resistant to both drugs when the plasmid has a deletion over the CAN1 and CYH2 genes.	Canavanine	116-126	arginine permease CAN1	Saccharomyces cerevisiae S288C	62-66
8852838-2	1996	A can1 cyh2 cell carrying two negative selection markers, the CAN1 and CYH2 genes, on a YCp plasmid is sensitive to canavanine and cycloheximide, but the cell becomes resistant to both drugs when the plasmid has a deletion over the CAN1 and CYH2 genes.	Canavanine	116-126	ribosomal 60S subunit protein L28	Saccharomyces cerevisiae S288C	71-75
7535234-2	1994	In contrast, intravenous infusion of L-canavanine (100 mg/kg), reported to be a selective inhibitor of inducible NO synthase in vitro, 60 min and 180 min after lipopolysaccharide challenge, produced an increase in mean arterial pressure and reversed the lipopolysaccharide induced hypotension.	Canavanine	37-49	nitric oxide synthase 2	Rattus norvegicus	103-124
7626659-9	1995	Both normal fibronectin and fibronectin in which canavanine replaced arginine were stable for 20 h in cells treated with brefeldin A or monensin.	Canavanine	49-59	fibronectin 1	Homo sapiens	28-39
7626663-0	1995	Consequences of the overexpression of ubiquitin in yeast: elevated tolerances of osmostress, ethanol and canavanine, yet reduced tolerances of cadmium, arsenite and paromomycin.	Canavanine	105-115	ubiquitin	Saccharomyces cerevisiae S288C	38-47
7626663-4	1995	It is noteworthy that tolerance of the amino acid analogue canavanine was markedly increased by ubiquitin overexpression, yet resistance to at least three other agents that contribute to accumulation of aberrant proteins (arsenite, cadmium, paromomycin) was decreased.	Canavanine	59-69	ubiquitin	Saccharomyces cerevisiae S288C	96-105
8381431-12	1993	However, pre1-1 pre4-1 double mutants showed enhanced canavanine sensitivity and increased accumulation of ubiquitin protein conjugates, as compared with pre1-1 single mutants.	Canavanine	54-64	proteasome core particle subunit beta 4	Saccharomyces cerevisiae S288C	9-13
7513645-3	1994	Three nitric oxide synthase (NOS) inhibitors affected transmural nerve stimulation induced relaxation responses in the rabbit urethra and the activity of soluble nitric oxide synthase with the same rank order of potency, i.e., NG-nitro-L-arginine (NNA) > NG-methyl-L-arginine (NMA) > canavanine (CAN).	Canavanine	290-300	nitric oxide synthase, brain	Oryctolagus cuniculus	6-27
8264608-2	1994	Disruption of the MLH1 gene results in elevated spontaneous mutation rates during vegetative growth as measured by forward mutation to canavanine resistance and reversion of the hom3-10 allele.	Canavanine	135-145	mismatch repair ATPase MLH1	Saccharomyces cerevisiae S288C	18-22
8381431-12	1993	However, pre1-1 pre4-1 double mutants showed enhanced canavanine sensitivity and increased accumulation of ubiquitin protein conjugates, as compared with pre1-1 single mutants.	Canavanine	54-64	proteasome core particle subunit beta 7	Saccharomyces cerevisiae S288C	16-20
1334021-6	1992	Haploid msh2 mutants displayed an increase of 85-fold in the rate of spontaneous mutation to canavanine resistance.	Canavanine	93-103	mismatch repair ATPase MSH2	Saccharomyces cerevisiae S288C	8-12
1902836-6	1991	The prolonged expression of hsp70 RNA during recovery from heat shock was also observed in young flies fed canavanine, an arginine analogue.	Canavanine	107-117	Heat-shock-protein-70Ab	Drosophila melanogaster	28-33
1612105-2	1992	L-Canavanine, a selective inhibitor of inducible nitric oxide synthase, augmented contractile responses in vessels from endotoxin, but not saline-pretreated animals.	Canavanine	0-12	nitric oxide synthase 2	Rattus norvegicus	39-70
1874726-0	1991	Studies of L-canavanine incorporation into insectan lysozyme.	Canavanine	11-23	lysozyme	Bombyx mori	52-60
1874726-2	1991	Maximum canavanine incorporation into M. sexta lysozyme occurs when the larvae are provided 1 mg of canavanine g-1 fresh body weight.	Canavanine	8-18	lysozyme	Bombyx mori	47-55
1874726-2	1991	Maximum canavanine incorporation into M. sexta lysozyme occurs when the larvae are provided 1 mg of canavanine g-1 fresh body weight.	Canavanine	100-110	lysozyme	Bombyx mori	47-55
1874726-3	1991	Analysis of canavanine-containing lysozyme purified from these insects reveals that 21% of the arginine residues are replaced by canavanine; this residue substitution results in a loss of 49.5% of the catalytic activity.	Canavanine	12-22	lysozyme	Bombyx mori	34-42
1874726-3	1991	Analysis of canavanine-containing lysozyme purified from these insects reveals that 21% of the arginine residues are replaced by canavanine; this residue substitution results in a loss of 49.5% of the catalytic activity.	Canavanine	129-139	lysozyme	Bombyx mori	34-42
1874726-6	1991	In contrast, replacement of 17% of the arginine in H. cecropia lysozyme by canavanine fails to affect the catalytic activity.	Canavanine	75-85	lysozyme	Bombyx mori	63-71
1874726-10	1991	The ability of incorporated canavanine to inhibit M. sexta lysozyme activity selectively may result from the fact that replacement of any one of the 3 arginine residues at position 23, 42, or 107 by canavanine causes the loss of catalytic activity.	Canavanine	28-38	lysozyme	Bombyx mori	59-67
1874726-10	1991	The ability of incorporated canavanine to inhibit M. sexta lysozyme activity selectively may result from the fact that replacement of any one of the 3 arginine residues at position 23, 42, or 107 by canavanine causes the loss of catalytic activity.	Canavanine	199-209	lysozyme	Bombyx mori	59-67
2001673-9	1991	Strains carrying the pre1-1 mutation show enhanced sensitivity to stresses such as incorporation of the amino acid analogue canavanine into proteins or a combination of poor growth medium and elevated temperature.	Canavanine	124-134	proteasome core particle subunit beta 4	Saccharomyces cerevisiae S288C	21-27
1963807-7	1990	Similarly, pretreatment of the cells with the L-arginine analogues, L-canavanine (IC50 60 microM) or NG-monomethyl-L-arginine (IC50 2.5 microM), inhibited the cyclic GMP response to endothelin-1.	Canavanine	68-80	5'-nucleotidase, cytosolic II	Mus musculus	166-169
1963807-7	1990	Similarly, pretreatment of the cells with the L-arginine analogues, L-canavanine (IC50 60 microM) or NG-monomethyl-L-arginine (IC50 2.5 microM), inhibited the cyclic GMP response to endothelin-1.	Canavanine	68-80	endothelin 1	Rattus norvegicus	182-194
1963807-10	1990	The Ca2+ ionophore ionomycin induced a transient rise in cyclic GMP levels, which was also suppressed by preincubation in the presence of either haemoglobin or the L-arginine analogues L-canavanine or NG-monomethyl-L-arginine.	Canavanine	185-197	5'-nucleotidase, cytosolic II	Mus musculus	64-67
3988798-8	1985	When a HeLa transformant was incubated with the arginine analogue canavanine, the major form of newly synthesized OTC detected was a species migrating slightly more slowly than the normal precursor; little mature-sized subunit was recovered.	Canavanine	66-76	ornithine transcarbamylase	Homo sapiens	114-117
2314485-4	1990	The PAF- and acetylcholine (ACh)-induced relaxations of mesenteric artery were dependent on the presence of endothelium and were inhibited by either hydroquinone and methylene blue, which inhibit the action of endothelium-derived relaxing factor (EDRF), or L-canavanine, which inhibits the formation of nitric oxide from L-arginine.	Canavanine	257-269	PCNA clamp associated factor	Rattus norvegicus	4-7
2760038-0	1989	L-canavanine incorporation into vitellogenin and macromolecular conformation.	Canavanine	0-12	putative uncharacterized protein LOC400499	Homo sapiens	32-44
2760038-2	1989	Canavanine, a substrate for arginyl-tRNA synthetase, is incorporated into nascent polypeptide chains in place of arginine.	Canavanine	0-10	arginyl-tRNA synthetase 1	Homo sapiens	28-51
2760038-4	1989	Chemical, physical, and immunological studies of native and canavanine-containing vitellogenin obtained from female migratory locusts (Locusta migratoria migratorioides (Orthoptera] provide the first experimental evidence that canavanine can disrupt the tertiary and/or quaternary structure that yields the three-dimensional conformation unique to the protein.	Canavanine	60-70	putative uncharacterized protein LOC400499	Homo sapiens	82-94
2760038-4	1989	Chemical, physical, and immunological studies of native and canavanine-containing vitellogenin obtained from female migratory locusts (Locusta migratoria migratorioides (Orthoptera] provide the first experimental evidence that canavanine can disrupt the tertiary and/or quaternary structure that yields the three-dimensional conformation unique to the protein.	Canavanine	227-237	putative uncharacterized protein LOC400499	Homo sapiens	82-94
2656711-3	1989	Canavanine replacement for arginine causes a total loss of detectable antibacterial activity for diptericin B and diptericin C, whereas diptericin A and peak V protein are severely inhibited.	Canavanine	0-10	Diptericin B	Drosophila melanogaster	97-109
2656711-3	1989	Canavanine replacement for arginine causes a total loss of detectable antibacterial activity for diptericin B and diptericin C, whereas diptericin A and peak V protein are severely inhibited.	Canavanine	0-10	Diptericin A	Drosophila melanogaster	97-107
2656711-5	1989	Analysis of the hydrolysate of diptericin A reveals that one-third of the 3 arginyl residues are replaced by canavanine.	Canavanine	109-119	Diptericin A	Drosophila melanogaster	31-43
2565101-11	1989	Since the elimination reactions take place under mild conditions, they may occur in vivo following oxidation at the alpha-C of L-canavanine (ingested or formed endogenously) or of other amino acids with a good leaving group in the gamma-position (e.g., S-adenosylmethionine, methionine sulfoximine, homocyst(e)ine, or cysteine-homocysteine mixed disulfide) by an L-amino acid oxidase, a transaminase, or a dehydrogenase.	Canavanine	127-139	interleukin 4 induced 1	Homo sapiens	363-383
2447682-14	1987	Serum amylase and lipase levels were elevated following one sc injection of 2.0 g/kg canavanine; after three daily injections both serum enzymes were depleted.	Canavanine	85-95	lipase G, endothelial type	Rattus norvegicus	18-24
6389572-2	1984	When the conversion of radiolabeled proinsulin to insulin was inhibited by replacing arginine and lysine with the aminoacid analogs, canavanine and thialysine, the nonconverted radioactive material remained associated with Golgi-derived, coated secretory granules.	Canavanine	133-143	insulin	Homo sapiens	36-46
6389572-2	1984	When the conversion of radiolabeled proinsulin to insulin was inhibited by replacing arginine and lysine with the aminoacid analogs, canavanine and thialysine, the nonconverted radioactive material remained associated with Golgi-derived, coated secretory granules.	Canavanine	133-143	insulin	Homo sapiens	39-46
6432958-8	1984	L-Canavanine inhibited synthesis of the virus-specific proteins NP-1 and VP3 and synthesis of BPV DNA.	Canavanine	0-12	hypothetical protein	Bovine parvovirus	64-76
6493229-8	1984	Chicken 18S and 28S rRNA synthesis was inhibited, and actin mRNA levels measured with cloned cDNA encoding chicken beta-actin slowly declined in canavanine-treated cells.	Canavanine	145-155	actin, beta	Gallus gallus	115-125
2185124-3	1990	Pre-growth of lon+ cells in the presence of canavanine induced proteolytic activity following growth in minimal media as did stress agents such as heat, alcohol and puromycin: the lon mutant did not show the increased activity following canavanine treatment.	Canavanine	44-54	putative ATP-dependent Lon protease	Escherichia coli	14-17
2674681-2	1989	This gene, which we have designated STI1, for stress inducible, was also induced by the amino acid analog canavanine and showed a slight increase in expression as cells moved into stationary phase.	Canavanine	106-116	Hsp90 cochaperone STI1	Saccharomyces cerevisiae S288C	36-40
3619450-4	1987	Eukaryotic initiation factor (eIF)-2 alpha phosphorylation is moderately to strongly induced by Na arsenite and diamide, but only slightly to imperceptibly affected by iodoacetamide, azetidine carboxylic acid, and canavanine.	Canavanine	214-224	eukaryotic translation initiation factor 2 subunit alpha	Homo sapiens	0-42
2998480-6	1985	Canavanine had varying effects on the secretion of plasma proteins; ranging from a 43-53% inhibition of secretion of alpha 1 antitrypsin and alpha 1 anti-chrymotrypsin to nearly abolishing (93% inhibition) secretion of transferrin.	Canavanine	0-10	transferrin	Homo sapiens	219-230
2998480-8	1985	Two of the canavanine-treated proteins (albumin and transferrin) which underwent marked changes in electrophoretic mobility were more sensitive than untreated proteins to proteolysis by Staphylococcus Aureus V8 proteinase.	Canavanine	11-21	transferrin	Homo sapiens	52-63
3970979-5	1985	Arginine, phenylalanine and methionine inhibited the induction of ornithine decarboxylase activity by the tumor promoter to degrees comparable to those elicited by their analogs canavanine and homoarginine, beta-2-thienyl-DL-alanine, and ethionine, respectively.	Canavanine	178-188	ornithine decarboxylase 1	Homo sapiens	66-89
6421997-7	1984	Treatments known to stimulate the synthesis of heat shock proteins (carotid occlusion, hyperthermia, Cd2+, canavanine, and ethanol) induced ODC activity in the liver, whereas only hyperthermia and ethanol caused significant increases in spleen ODC activity.	Canavanine	107-117	ornithine decarboxylase 1	Rattus norvegicus	140-143
6283633-2	1982	Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller products.	Canavanine	74-84	proopiomelanocortin	Rattus norvegicus	111-131
6684664-3	1983	Here we show that incubation of chicken embryo erythroid cells in a medium in which arginine has been substituted by its amino acid analogue, canavanine, results in the inhibition of the posttranslational assembly of vimentin into the TX-100-insoluble filaments.	Canavanine	142-152	vimentin	Gallus gallus	217-225
6644098-2	1983	Incubation of isolated epidermal cells with mM concentrations of glycine, asparagine, glutamic acid, canavanine, arginine, and/or lysine inhibited dramatically the induction of ornithine decarboxylase activity by the tumor promoter.	Canavanine	101-111	ornithine decarboxylase, structural 1	Mus musculus	177-200
6644098-4	1983	Arginine and its analog, canavanine, inhibited to the same degree TPA-induced ornithine decarboxylase activity, and potentiated to the same extent the inhibitory effects of glutamic acid, asparagine, and glycine on this enzyme.	Canavanine	25-35	ornithine decarboxylase, structural 1	Mus musculus	78-101
6639687-13	1983	Lysine, arginine, L-canavanine and polymyxin B all affected NAG release from lysosomes in vitro.	Canavanine	18-30	O-GlcNAcase	Rattus norvegicus	60-63
6684664-6	1983	The effect of canavanine on the assembly of vimentin did not prevent the assembly of arginine-vimentin, as cells labeled with [35S]methionine first in the presence of canavanine and then in the presence of arginine contained labeled canavanine-vimentin only in the soluble fraction, and arginine-vimentin in both the soluble and cytoskeletal fractions.	Canavanine	14-24	vimentin	Gallus gallus	44-52
6283633-3	1982	Pro-opiomelanocortin that accumulated in the presence of canavanine was also sulfated.	Canavanine	57-67	proopiomelanocortin	Rattus norvegicus	0-20
392306-0	1979	Effects of spermine on the detection of induced forward mutation at the Can1 locus in yeast: evidence for selection against canavanine-resistant mutants.	Canavanine	124-134	arginine permease CAN1	Saccharomyces cerevisiae S288C	72-76
6274867-0	1982	Incorporation of canavanine into rat pars intermedia proteins inhibits the maturation of pro-opiomelanocortin, the common precursor to adrenocorticotropin and beta-lipotropin.	Canavanine	17-27	proopiomelanocortin	Rattus norvegicus	89-109
6274867-3	1982	Preincubation of rat neurointermediate lobes for 16 h in the presence of 10 mM canavanine results in the production of pro-opiomelanocortin molecules in which most, if not all, the arginine residues have been replaced by canavanine.	Canavanine	79-89	proopiomelanocortin	Rattus norvegicus	119-139
6274867-3	1982	Preincubation of rat neurointermediate lobes for 16 h in the presence of 10 mM canavanine results in the production of pro-opiomelanocortin molecules in which most, if not all, the arginine residues have been replaced by canavanine.	Canavanine	221-231	proopiomelanocortin	Rattus norvegicus	119-139
6274867-4	1982	Identification of canavanine-containing pro-opiomelanocortin forms was done by two-dimensional electrophoresis, tryptic and chymotryptic peptide mapping, as well as by analysis, on polyacrylamide gels in the presence of sodium dodecyl sulfate, of the fragments resulting from a partial digestion with chymotrypsin.	Canavanine	18-28	proopiomelanocortin	Rattus norvegicus	40-60
6274867-5	1982	During pulse-chase experiments, canavanine-containing pro-opiomelanocortin molecules were found to be processed at a much slower rate than the normal precursor forms: after a 2-h chase, conversion of approximately 25% of the analog-containing prophormone was observed compared to 83% of the nonanalog-containing precursors.	Canavanine	32-42	proopiomelanocortin	Rattus norvegicus	54-74
6274867-7	1982	These results indicate that canavanine incorporation into neurointermediate lobe proteins considerably slows down the conversion of pro-opiomelanocortin into its different end products.	Canavanine	28-38	proopiomelanocortin	Rattus norvegicus	132-152
6901532-8	1980	In cultures exposed to canavanine, the rates of accumulation of P88 and P71,72 increased from basal to new plateau levels in about 1.5 hours, while P23 required about 2.5 hours.	Canavanine	23-33	zinc finger protein 398	Homo sapiens	72-75
6901532-8	1980	In cultures exposed to canavanine, the rates of accumulation of P88 and P71,72 increased from basal to new plateau levels in about 1.5 hours, while P23 required about 2.5 hours.	Canavanine	23-33	prostaglandin E synthase 3	Homo sapiens	148-151
392306-1	1979	The effect of exogenous spermine tetrahydrochloride (0.5 mg/ml) on hydrazine- and nitrous acid-induced forward mutation to canavanine resistance (CAN1 leads to can1, normal to defective arginine permease) was examined in stationary-phase haploid Saccharomyces cerevisiae.	Canavanine	123-133	arginine permease CAN1	Saccharomyces cerevisiae S288C	146-150
392306-1	1979	The effect of exogenous spermine tetrahydrochloride (0.5 mg/ml) on hydrazine- and nitrous acid-induced forward mutation to canavanine resistance (CAN1 leads to can1, normal to defective arginine permease) was examined in stationary-phase haploid Saccharomyces cerevisiae.	Canavanine	123-133	arginine permease CAN1	Saccharomyces cerevisiae S288C	160-164
383231-3	1979	Incubation of these cells in the presence of the arginine analogue, L-canavanine, resulted in the inhibition of conversion of newly formed proinsulin to insulin and the appearance of a radioactive component of molecular weight 11,000-12,000.	Canavanine	68-80	insulin	Bos taurus	139-149
383231-3	1979	Incubation of these cells in the presence of the arginine analogue, L-canavanine, resulted in the inhibition of conversion of newly formed proinsulin to insulin and the appearance of a radioactive component of molecular weight 11,000-12,000.	Canavanine	68-80	insulin	Bos taurus	142-149
16660586-2	1978	Ten-fold more canavanine was required to cause a 50% reduction in the level of nitrate reductase activity (NRA) in root tips than in mature root sections.	Canavanine	14-24	nitrate reductase [NADH] 1	Zea mays	79-96
372045-1	1979	A system of strains and growth media was developed to allow efficient detection of forward mutation, reversion, complementation, and suppression at the canavanine-resistance (CAN1) locus of Saccharomyces cerevisiae.	Canavanine	152-162	arginine permease CAN1	Saccharomyces cerevisiae S288C	175-179
34051735-13	2021	Finally, doxazosin, quinostatin, canavanine, and chrysin were identified to exert anti-glioma effects by targeting XRCC2.	Canavanine	33-43	X-ray repair cross complementing 2	Homo sapiens	115-120
351388-4	1978	The NPs giving a positive response stimulated forward mutation to canavanine resistance (CAN1 leads to can1) and reversion of the his1-7 missense marker.	Canavanine	66-76	arginine permease CAN1	Saccharomyces cerevisiae S288C	89-93
351388-4	1978	The NPs giving a positive response stimulated forward mutation to canavanine resistance (CAN1 leads to can1) and reversion of the his1-7 missense marker.	Canavanine	66-76	arginine permease CAN1	Saccharomyces cerevisiae S288C	103-107
7365878-4	1980	It was found that the electrophoretic mobility of the major gag-related cell-free product of both Rauscher murine leukemia virus (R-MuLV) and Moloney murine sarcoma virus 124 (Mo-MuSV-124) RNA was dependent on the concentration of canavanine used during translation.	Canavanine	231-241	melanoma antigen	Mus musculus	60-63
7365878-5	1980	As the canavanine concentration was increased up to 4 mM, the apparent size of the major gag-related polypeptide also increased from 65,000 (R-MuLV RNA) or 63,000 (Mo-MuSV-124 RNA) to approximately 80,000 daltons.	Canavanine	7-17	melanoma antigen	Mus musculus	89-92
16659859-8	1977	Amino acids or amino acid analogues added singly to the induction medium have a similar effect: i.e. when the induction of nitrate reductase is inhibited in the root tips (lysine, canavanine, azaserine, azetidine-2-carboxylic acid, dl-4-azaleucine, asparagine, and glutamine), that inhibition is more severe in mature root sections.	Canavanine	180-190	nitrate reductase [NADH] 1	Zea mays	123-140
33732412-0	2021	The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin.	Canavanine	44-54	furin, paired basic amino acid cleaving enzyme	Homo sapiens	103-108
33230565-5	2021	Combination of ADT with canavanine triggered catastrophic ER stress via the eIF2alpha-ATF4(GADD34)-CHOP pathway, thereby inducing apoptosis; the same signaling arm was irrelevant in ADT-related radiosensitization.	Canavanine	24-34	eukaryotic translation initiation factor 2A	Homo sapiens	76-85
33230565-5	2021	Combination of ADT with canavanine triggered catastrophic ER stress via the eIF2alpha-ATF4(GADD34)-CHOP pathway, thereby inducing apoptosis; the same signaling arm was irrelevant in ADT-related radiosensitization.	Canavanine	24-34	activating transcription factor 4	Homo sapiens	86-90
33230565-5	2021	Combination of ADT with canavanine triggered catastrophic ER stress via the eIF2alpha-ATF4(GADD34)-CHOP pathway, thereby inducing apoptosis; the same signaling arm was irrelevant in ADT-related radiosensitization.	Canavanine	24-34	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	91-97
33230565-5	2021	Combination of ADT with canavanine triggered catastrophic ER stress via the eIF2alpha-ATF4(GADD34)-CHOP pathway, thereby inducing apoptosis; the same signaling arm was irrelevant in ADT-related radiosensitization.	Canavanine	24-34	DNA damage inducible transcript 3	Homo sapiens	99-103
33732412-2	2021	Through the replacement of arginine by the less basic canavanine, new inhibitors targeting furin in the trans-Golgi network were developed.	Canavanine	54-64	furin, paired basic amino acid cleaving enzyme	Homo sapiens	91-96
33008000-6	2020	At the molecular level, canavanine inhibited prosurvival kinases such as FAK, Akt and AMPK.	Canavanine	24-34	protein tyrosine kinase 2	Homo sapiens	73-76
33008000-6	2020	At the molecular level, canavanine inhibited prosurvival kinases such as FAK, Akt and AMPK.	Canavanine	24-34	AKT serine/threonine kinase 1	Homo sapiens	78-81
33008000-6	2020	At the molecular level, canavanine inhibited prosurvival kinases such as FAK, Akt and AMPK.	Canavanine	24-34	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	86-90
31225941-4	2019	Students use CRISPR/Cas9 and nonhomologous end joining to generate frameshift insertion and deletion mutations in the CAN1 gene, which are easily selected for using media plates that have canavanine.	Canavanine	188-198	arginine permease CAN1	Saccharomyces cerevisiae S288C	118-122