PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 9316613-13 1997 Administration of PGF2 alpha on Day 12 of the estrous cycle stimulated a decline in P4 secretion and an increase in the secretion of PGF, LTB, and LTC from the CL. Prostaglandins F 18-21 lymphotoxin beta Bos taurus 138-141 9452873-5 1997 On the other hand, PGF release was significantly (p < 0.05) inhibited by both GH and IGF-I at all concentrations tested. Prostaglandins F 19-22 IGFI Bos taurus 88-93 9685995-1 1997 Prostate growth factor (PGF) was the first growth factor isolated from the prostate. Prostaglandins F 24-27 placental growth factor Homo sapiens 0-22 11667278-1 1996 Novel prostaglandin F(2)(alpha) derivatives, functionalized at C13 and C14, have been prepared. Prostaglandins F 6-21 homeobox C13 Homo sapiens 63-66 8880461-0 1996 Treatment with recombinant bovine interferon-tau in utero attenuates secretion of prostaglandin F from cultured endometrial epithelial cells. Prostaglandins F 82-97 interferon tau-2 Bos taurus 34-48 8877581-12 1996 AIF4-alone increased IP production but blocked histamine- and PGF(2 alpha)-dependent IP increases. Prostaglandins F 62-65 itchy E3 ubiquitin protein ligase Homo sapiens 0-4 8641206-7 1996 Granulosa cell PGF and PGE secretion was increased by TGF alpha but suppressed by TGF beta in vitro. Prostaglandins F 15-18 transforming growth factor alpha Homo sapiens 54-63 8641206-7 1996 Granulosa cell PGF and PGE secretion was increased by TGF alpha but suppressed by TGF beta in vitro. Prostaglandins F 15-18 transforming growth factor beta 1 Homo sapiens 82-90 8838241-2 1995 AA (0.2 mg), PLA-2 (1 U/ml) and CaI (4 micrograms/ml) increased PGF and PGE secretion. Prostaglandins F 64-67 LOC104974671 Bos taurus 13-18 16727857-15 1996 In conclusion, the results suggest that 1) hCG-induced CL are functional but appear to be smaller and secrete less P(4) than spontaneous CL of similar age, and 2) the small size and reduced secretary function observed is not necessarily due to PGF(2alpha) secreted by the uterine endometrium but, probably, to inherent characteristics. Prostaglandins F 244-247 hypertrichosis 2 (generalised, congenital) Homo sapiens 43-46 8838241-7 1995 The stimulatory effect of PLA-2 on PGF and PGE secretion was greater in pregnant than cyclic endometrium. Prostaglandins F 35-38 LOC104974671 Bos taurus 26-31 7700221-4 1994 Many studies suggested that Polypeptide Growth Factors (PGF) such as Insulin-like Growth Factor I (IGF-I), Platelet Derived Growth Factor (PDGF), Transforming Growth Factor B (TGF-B), Epidermal Growth Factor (EGF), are important mediators of cellular events in wound healing. Prostaglandins F 56-59 epidermal growth factor Homo sapiens 209-212 21153167-3 1995 We have previously demonstrated, using subluteolytic levels of PGF(2alpha), the existence of functional high affinity luteal PGF(2alpha) receptors which show desensitization and recovery after 6 to 9 h. The present study, using direct intra-arterial infusions of PGF(2alpha) into the autotransplanted ovary in conscious sheep, was designed to probe for the existence of functional high and low affinity states of the PGF(2alpha) receptor in the corpus luteumin vivo. Prostaglandins F 63-66 prostaglandin F2-alpha receptor Ovis aries 125-145 7700221-4 1994 Many studies suggested that Polypeptide Growth Factors (PGF) such as Insulin-like Growth Factor I (IGF-I), Platelet Derived Growth Factor (PDGF), Transforming Growth Factor B (TGF-B), Epidermal Growth Factor (EGF), are important mediators of cellular events in wound healing. Prostaglandins F 56-59 transforming growth factor beta 1 Homo sapiens 176-181 7700221-4 1994 Many studies suggested that Polypeptide Growth Factors (PGF) such as Insulin-like Growth Factor I (IGF-I), Platelet Derived Growth Factor (PDGF), Transforming Growth Factor B (TGF-B), Epidermal Growth Factor (EGF), are important mediators of cellular events in wound healing. Prostaglandins F 56-59 epidermal growth factor Homo sapiens 184-207 8248549-5 1993 The addition of IGF-I (10(-8) M) to the perfusing medium effected an inhibition of TxB2 and PGF within two and one-half hours of exposure. Prostaglandins F 92-95 insulin like growth factor 1 Homo sapiens 16-21 8248549-7 1993 Because both TxB2 and PGF are vaso-constrictors, we have proposed that IGF-I may enhance vasodilation in the placenta. Prostaglandins F 22-25 insulin like growth factor 1 Homo sapiens 71-76 8321227-13 1993 The rat FGF-9 cDNA was also cloned, and the structural analysis indicated that the PGF-9 gene is highly conserved. Prostaglandins F 83-86 fibroblast growth factor 9 Rattus norvegicus 8-13 8468663-2 1993 The hypothesis of this article is that growth of the fetal lung is stimulated by a pulmonary growth factor (PGF) produced by the kidneys, which is modulated by a feedback signal from the lungs, a pulmonary-derived renotropin (PDR). Prostaglandins F 108-111 placenta growth factor Oryctolagus cuniculus 83-106 16726831-6 1990 Platelet-activating factor had distinct negative and positive dose effects on PGF and PGE-2 secretion, respectively, by explants from cyclic cows, whereas PG secretion was not altered by PAF in the endometrium of pregnant cows. Prostaglandins F 78-81 PCNA-associated factor Bos taurus 0-26 1518379-5 1992 Interleukin-1 beta had no effect on prostaglandin production by stromal cell cultures but increased epithelial production of PGE2 and, to a lesser extent, PGF. Prostaglandins F 155-158 interleukin 1 beta Bos taurus 0-18 1518379-6 1992 Conversely, granulocyte-macrophage colony stimulating factor had no effect on epithelial cells but reduced secretion of PGE2 and PGF from stromal cells. Prostaglandins F 129-132 colony stimulating factor 2 Bos taurus 12-60 1750474-6 1991 Gonadotropin-releasing hormone significantly inhibited the release of placental prostaglandin E, prostaglandin F, and thromboxane B2 in a dose-dependent fashion. Prostaglandins F 97-112 gonadotropin releasing hormone 1 Homo sapiens 0-30 1995855-10 1991 PGF release into the medium from the same gland cell cultures was significantly elevated by hormonal treatment, being greatest (62.0 +/- 11.3) with oestradiol alone, and was strongly inhibited in all wells by addition of PAF and stromal cell medium. Prostaglandins F 0-3 PCNA clamp associated factor Homo sapiens 221-224 1995855-12 1991 PAF was inhibitory on PGF release, while gland cell medium was without effect. Prostaglandins F 22-25 PCNA clamp associated factor Homo sapiens 0-3 1786082-2 1991 In experiment 1, all interferon molecules (bTP-1, oTP-1, bIFN-alpha and hIFN-alpha) equally inhibited secretion of PGF and PGE2 from endometrial explant cultures obtained at day 17 of the estrous cycle. Prostaglandins F 115-118 interferon alpha 1 Homo sapiens 72-82 1786082-8 1991 Furthermore, other interferon-alpha molecules, including bIFN-alpha, hIFN-alpha, and oTP-1, also reduced PGF and PGE2 secretion in culture. Prostaglandins F 105-108 INFA Bos taurus 19-35 1786082-8 1991 Furthermore, other interferon-alpha molecules, including bIFN-alpha, hIFN-alpha, and oTP-1, also reduced PGF and PGE2 secretion in culture. Prostaglandins F 105-108 interferon alpha 1 Homo sapiens 69-79 2164916-0 1990 Reorientation of prostaglandin F secretion by calcium ionophore, estradiol, and prolactin in perifused porcine endometrium. Prostaglandins F 17-32 prolactin Sus scrofa 80-89 2164916-10 1990 However, EV and PRL interacted to reorient secretion of PGF from endocrine to exocrine at 6 h (P less than 0.01) and 12 h (P less than 0.01) after EV. Prostaglandins F 56-59 prolactin Sus scrofa 16-19 16726832-1 1990 Maternal heat stress in cattle may disrupt pregnancy by elevating uterine prostaglandin F(2 alpha) (PGF(2 alpha)) secretion. Prostaglandins F 74-89 placental growth factor Bos taurus 100-103 21890190-7 2011 The total number of the CLs was higher (P < 0.05) in animals treated with PGF(2alpha)/PMSG/hCG. Prostaglandins F 77-80 hypertrichosis 2 (generalised, congenital) Homo sapiens 94-97 31087493-4 2019 Consistent with the finding that Leydig cells expressed aldo-keto reductase 1B7 (PGF synthase) and PGE synthase 2, induction of COX-2 by hCG caused a marked increase in testicular PGF 2alpha and PGE 2 levels. Prostaglandins F 81-84 prostaglandin-endoperoxide synthase 2 Mus musculus 128-133 31087493-9 2019 These results indicate that COX-2 is induced in Leydig cells by activation of C/EBPbeta via reduction of CHOP expression upon gonadotropin-stimulation to produce PGF 2alpha and PGE 2 . Prostaglandins F 162-165 prostaglandin-endoperoxide synthase 2 Mus musculus 28-33 31087493-9 2019 These results indicate that COX-2 is induced in Leydig cells by activation of C/EBPbeta via reduction of CHOP expression upon gonadotropin-stimulation to produce PGF 2alpha and PGE 2 . Prostaglandins F 162-165 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 78-87 31087493-9 2019 These results indicate that COX-2 is induced in Leydig cells by activation of C/EBPbeta via reduction of CHOP expression upon gonadotropin-stimulation to produce PGF 2alpha and PGE 2 . Prostaglandins F 162-165 DNA-damage inducible transcript 3 Mus musculus 105-109 23319937-7 2012 PGE(2) and PGF(2alpha) strongly suppress the early phase of adipocyte differentiation by enhancing their own production via receptor-mediated elevation of the expression of cycloxygenase-2, and they also suppress the function of PPARgamma. Prostaglandins F 11-14 peroxisome proliferator activated receptor gamma Homo sapiens 229-238 21890190-8 2011 The amount of E(2) and P(4) was lower (P < 0.05, P < 0.001, respectively) in pregnant gilts administrated with PGF(2alpha)/PMSG/hCG. Prostaglandins F 117-120 hypertrichosis 2 (generalised, congenital) Homo sapiens 134-137 21890190-10 2011 The content of WNT4 mRNA in conceptuses increased on particular Days studied in Control and PGF(2alpha)/PMSG/hCG administered animals. Prostaglandins F 92-95 Wnt family member 4 Sus scrofa 15-19 21505051-5 2011 Treatment with PGF(2alpha) for 10 h increased mRNA for almost all of these genes (all expect CXCL2 and CCL11) in d 17 CL but not d 9 CL. Prostaglandins F 15-18 C-X-C motif chemokine ligand 2 Homo sapiens 93-98 21890190-11 2011 WNT7A and CTNNB1 were affected by PGF(2alpha)/PMSG/hCG treatment in both conceptuses (P < 0.001, P < 0.05) and endometrial tissue (P < 0.001, P < 0.01). Prostaglandins F 34-37 Wnt family member 7A Sus scrofa 0-5 21505051-5 2011 Treatment with PGF(2alpha) for 10 h increased mRNA for almost all of these genes (all expect CXCL2 and CCL11) in d 17 CL but not d 9 CL. Prostaglandins F 15-18 C-C motif chemokine ligand 11 Homo sapiens 103-108 21505051-9 2011 However, PGF(2alpha) + epostane increased expression of all of these genes except CCL11. Prostaglandins F 9-12 C-C motif chemokine ligand 11 Homo sapiens 82-87 21890190-11 2011 WNT7A and CTNNB1 were affected by PGF(2alpha)/PMSG/hCG treatment in both conceptuses (P < 0.001, P < 0.05) and endometrial tissue (P < 0.001, P < 0.01). Prostaglandins F 34-37 catenin beta 1 Sus scrofa 10-16 21890190-12 2011 The PGF(2alpha)/PMSG/hCG treatment resulted in elevated expression of WNT4 (P < 0.001) and CTNNB1 (P < 0.05) in luteal tissue in comparison to the Control gilts. Prostaglandins F 4-7 hypertrichosis 2 (generalised, congenital) Homo sapiens 21-24 21890190-12 2011 The PGF(2alpha)/PMSG/hCG treatment resulted in elevated expression of WNT4 (P < 0.001) and CTNNB1 (P < 0.05) in luteal tissue in comparison to the Control gilts. Prostaglandins F 4-7 Wnt family member 4 Sus scrofa 70-74 21890190-12 2011 The PGF(2alpha)/PMSG/hCG treatment resulted in elevated expression of WNT4 (P < 0.001) and CTNNB1 (P < 0.05) in luteal tissue in comparison to the Control gilts. Prostaglandins F 4-7 catenin beta 1 Sus scrofa 94-100 21890190-13 2011 Moreover, luteal amount of WNT5A mRNA was higher in PGF(2alpha)/PMSG/hCG animals in comparison to the Control group (P < 0.05). Prostaglandins F 52-55 Wnt family member 5A Sus scrofa 27-32 35443686-0 2022 Correction to: The N6-methyladenosine modification of circALG1 promotes the metastasis of colorectal cancer mediated by the miR-342-5p/PGF signalling pathway. Prostaglandins F 135-138 microRNA 342 Homo sapiens 124-131 34284148-2 2021 We present a systemic review and meta-analysis aimed to assess the outcomes with CD34-selected stem cell boost (SCB) for PGF in adult allo-HSCT patients. Prostaglandins F 121-124 CD34 molecule Homo sapiens 81-85 34284148-4 2021 After excluding review, duplicate, and non-relevant articles, we included 7 studies reporting outcomes following administration of CD34-selected SCB for PGF after allo-HSCT, including hematologic complete response (CR) and overall response rate (ORR), GVHD, and overall survival (OS). Prostaglandins F 153-156 CD34 molecule Homo sapiens 131-135 34284148-8 2021 RESULTS: We identified 209 patients who received CD34-selected SCB for PGF after allo-HSCT. Prostaglandins F 71-74 CD34 molecule Homo sapiens 49-53 34284148-19 2021 CONCLUSION: CD34-selected SCB improves outcomes after PGF post allo-HSCT with an acceptable toxicity profile. Prostaglandins F 54-57 CD34 molecule Homo sapiens 12-16 35569344-7 2022 During luteolysis, REN was downregulated at 48 h, whereas TGFB1 and SERPINE1 were dramatically upregulated in luteal tissue at 12 h after PGF. Prostaglandins F 138-141 transforming growth factor beta 1 Bos taurus 58-63 35569344-7 2022 During luteolysis, REN was downregulated at 48 h, whereas TGFB1 and SERPINE1 were dramatically upregulated in luteal tissue at 12 h after PGF. Prostaglandins F 138-141 serpin family E member 1 Bos taurus 68-76 35354250-2 2022 Herein, enhanced glycolytic enzyme PFKFB3 was demonstrated in the damaged BM EPCs of patients with poor graft function(PGF), a clinical model of EPC damage-associated poor hematopoiesis after allogeneic hematopoietic stem cell transplantation(allo-HSCT). Prostaglandins F 119-122 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 35-41 2838415-1 1988 The nucleotide sequence of a complete cDNA gene from a DP4-positive HLA-homozygous cell line, PGF, has been determined. Prostaglandins F 94-97 transcription factor Dp family member 3 Homo sapiens 55-58 35186676-8 2022 The expression of E-cadherin in the local RPE cells decreased, while alpha-SMA increased significantly in subretinal fibrosis lesions, and the application of anti-PGF neutralizing antibody could reverse these changes (P<0.05). Prostaglandins F 163-166 cadherin 1 Mus musculus 18-28 35186676-8 2022 The expression of E-cadherin in the local RPE cells decreased, while alpha-SMA increased significantly in subretinal fibrosis lesions, and the application of anti-PGF neutralizing antibody could reverse these changes (P<0.05). Prostaglandins F 163-166 actin alpha 2, smooth muscle, aorta Mus musculus 69-78 35387398-10 2022 TR incidence was related to etiology: incidence of PGF-induced TR was higher in the first period, while TR due to rejection and undefined causes occurred more frequently in three periods: in the first year, in the 10-14-year period following HTx, and in the long term (16-18 years). Prostaglandins F 51-54 coagulation factor II thrombin receptor Homo sapiens 0-2 35387398-10 2022 TR incidence was related to etiology: incidence of PGF-induced TR was higher in the first period, while TR due to rejection and undefined causes occurred more frequently in three periods: in the first year, in the 10-14-year period following HTx, and in the long term (16-18 years). Prostaglandins F 51-54 coagulation factor II thrombin receptor Homo sapiens 63-65 35387398-14 2022 The risk of mortality is greater in severe TR due to PGF or rejection. Prostaglandins F 53-56 coagulation factor II thrombin receptor Homo sapiens 43-45 2621710-6 1989 The gilts treated with PGF-2 alpha analogues had steroid profiles indistinguishable from those in controls but differing relaxin secretion patterns. Prostaglandins F 23-26 prorelaxin Sus scrofa 121-128 2838415-6 1988 Furthermore, this correspondence is found to be unaffected by the markers present at the DQ and DR loci, since the haplotypes of the PGF and Priess cell lines are, respectively, DR2,DQw1,DP4 and DR4,DQw3,DP4. Prostaglandins F 133-136 transcription factor Dp family member 3 Homo sapiens 187-190 2884095-2 1986 PGEs and Fs induced significant increases in basal TSH release of the order of 30% at 10(-9) or 10(-8) to 10(-5) or 10(-4) M. Only PGEs accentuated the TSH release induced by a half maximal dose of TRH (10(-9) M) of the order of 60% in a dose dependent manner (10(-9) to 10(-6) M of PGEs), whereas PGFs did not. Prostaglandins F 298-302 prostaglandin E synthase Rattus norvegicus 0-4 16726530-1 1988 In most cyclic females, prostaglandin F(2 alpha) (PGF(2 alpha)) triggers a uterine motility response resembling that of oxytocin (OT). Prostaglandins F 24-39 placental growth factor Homo sapiens 50-53 16726310-1 1987 An experiment was conducted to study an estrous synchronization regimen that involved the use of prostaglandin F(2alpha) (PGF(2alpha)) alone or in combination with estradiol benzoate (EB) and appointment breeding. Prostaglandins F 97-112 placental growth factor Bos taurus 122-125 2976174-3 1988 Several groups have observed the stimulation of hepatocyte growth in vitro by some platelet-associated activity, which was recently isolated from rat platelets as a 27-kDa protein called platelet growth factor (PGF). Prostaglandins F 211-214 myotrophin Rattus norvegicus 196-209 6203274-3 1984 Although pre-irradiation levels of PGF-MUM excretion in psoriatic patients were lower than those in normal subjects as previously reported, it was demonstrated that PGF-MUM excretion after UVB irradiation in psoriatic patients was fairly increased and amounted to near the mean pre-irradiation level in normal subjects. Prostaglandins F 35-38 latexin Homo sapiens 39-42 3490791-6 1986 Prostaglandin F also reduced IL-2 production, but to a lesser extent that M-PGE. Prostaglandins F 0-15 interleukin 2 Mus musculus 29-33 2419135-2 1986 The biochemical and physicochemical properties of prostate growth factor (PGF) in the extracts of benign prostatic hypertrophy (BPH) were investigated. Prostaglandins F 74-77 placental growth factor Homo sapiens 50-72 3468253-4 1986 Evaluation of the binding parameters revealed a competitive interaction between PGF 2 alpha and ZK 71 677 for the PGF 2 alpha-receptor molecule. Prostaglandins F 80-83 prostaglandin F receptor Rattus norvegicus 114-134 3863815-9 1985 15 PGF-ring compounds were treated with n-butylboronic acid and 13 failed to form a boronate derivative, suggesting that the orientation of the hydroxyl group at C-11 in these 13 metabolites is beta. Prostaglandins F 3-6 aldo-keto reductase family 1 member C4 Homo sapiens 162-166 6203274-1 1984 The influence of ultraviolet B (UVB) irradiation on the excretion of the main urinary metabolite of prostaglandin F1 alpha and F2 alpha (PGF-MUM) in 7 normal male volunteers and 7 male patients with stable psoriasis was examined. Prostaglandins F 137-140 latexin Homo sapiens 141-144 6203274-2 1984 The excretion of PGF-MUM was increased during the first 24 hours after UVB irradiation of back skin and was generally reduced to near pre-irradiation levels during the next 24 hours after irradiation, in both normal and psoriatic subjects. Prostaglandins F 17-20 latexin Homo sapiens 21-24 3872360-10 1985 After medium and high dose nisoldipine and after high dose nifedipine, PVR remained close to normoxic control levels during both hypoxic and PGF 2 alpha challenges. Prostaglandins F 141-144 PVR cell adhesion molecule Homo sapiens 71-74 6589650-7 1984 The increase in PGE and PGF production at 4 h as compared to 0.5 h following E2 injection was accompanied by increased PLA2 activity. Prostaglandins F 24-27 phospholipase A2 group IB Rattus norvegicus 119-123 6597721-2 1984 Indometacin proved to be a classical cyclooxygenase inhibitor (strong inhibition of PGE2 and TXB2 before and after pentagastrin stimulation and of PGF-MUM) while carprofen was an atypical inhibitor (weak inhibition of PGE2 before pentagastrin stimulation and no inhibition after, strong inhibition of TXB2 but without influence on PGF-MUM). Prostaglandins F 147-150 latexin Homo sapiens 151-154 6203274-3 1984 Although pre-irradiation levels of PGF-MUM excretion in psoriatic patients were lower than those in normal subjects as previously reported, it was demonstrated that PGF-MUM excretion after UVB irradiation in psoriatic patients was fairly increased and amounted to near the mean pre-irradiation level in normal subjects. Prostaglandins F 165-168 latexin Homo sapiens 169-172 6889790-2 1982 The addition of oxytocin led to a significant increase of PG E- and PG F-synthesis in decidua and to a significant increase in PG-synthesis in amnion. Prostaglandins F 68-73 oxytocin/neurophysin I prepropeptide Homo sapiens 16-24 6597497-17 1983 The analysis of our present data suggests that although a relationship exists between uterine PLA2 activity and PGF concentration, the role of PG synthetase could also be important in regulating PGF synthesis. Prostaglandins F 112-115 phospholipase A2 group IB Rattus norvegicus 94-98 6597663-2 1984 In the animals with marked preference for ethanol synthesis of prostaglandins E2 and F2 alpha, content of the prostaglandins F were distinctly higher. Prostaglandins F 110-126 dihydrolipoamide S-succinyltransferase Rattus norvegicus 78-93 6689628-1 1983 The effect of Angiotensin II (A-II) on 6-keto-prostaglandin F1 (6-keto-PGF1 alpha) and prostaglandin F (PGF) production by the rat uterus was studied using a novel superfusion technique. Prostaglandins F 46-61 angiotensinogen Rattus norvegicus 30-34 6689628-4 1983 In uterine horns from castrated, estrogen treated rats, A-II (10(-6)M) stimulated the production rate of 6-keto-PGF1 alpha in the myometrium nd PGF in the endometrium. Prostaglandins F 112-115 angiotensinogen Rattus norvegicus 56-60 6192638-1 1983 Twenty-four hour excretion of main urinary metabolite of prostaglandin F1 alpha and F2 alpha (PGF-MUM) in 18 patients with stable psoriasis (9 males and 9 females) and 18 almost age-matched healthy subjects (9 males and 9 females) was examined. Prostaglandins F 94-97 latexin Homo sapiens 98-101 6192638-2 1983 The mean excretion level of PGF-MUM in male psoriatic patients (15.2 +/- 4.0 micrograms/day) was significantly lower than that in male healthy subjects (22.8 +/- 3.3 micrograms/day) (p less than 0.01). Prostaglandins F 28-31 latexin Homo sapiens 32-35 7129348-4 1982 1) Twenty-four hours secretions of PGF-MUM in normal subjects were 18.4 +/- 9.1 microgram/day (24.5 +/- 9.2 microgram/day in male, 12.2 +/- 2.6 microgram/day in female) on an average. Prostaglandins F 35-38 latexin Homo sapiens 39-42 7129348-5 1982 The values of PGF-MUM in male were significantly higher than those in female (P less than 0.03). Prostaglandins F 14-17 latexin Homo sapiens 18-21 7129348-6 1982 2) Twenty-four hours secretions of PGF-MUM for the patients with pulmonary emphysema were significantly lower (P less than 0.01) than those in the normal controls (P less than 0.01), and the values of PGF-MUM were correlated significantly (r=0.451, P less than 0.05) with arterial oxygen partial pressure. Prostaglandins F 35-38 latexin Homo sapiens 39-42 7315896-4 1981 We found that oxytocin causes a significant increase in the production of both PGE and PGF in the decidua and in the production of PGE in the amnion. Prostaglandins F 87-90 oxytocin/neurophysin I prepropeptide Homo sapiens 14-22 7129348-6 1982 2) Twenty-four hours secretions of PGF-MUM for the patients with pulmonary emphysema were significantly lower (P less than 0.01) than those in the normal controls (P less than 0.01), and the values of PGF-MUM were correlated significantly (r=0.451, P less than 0.05) with arterial oxygen partial pressure. Prostaglandins F 35-38 latexin Homo sapiens 205-208 7129348-7 1982 3) Twenty-four hours secretions of PGF-MUM in the patients with asthma bronchiale, chronic bronchitis, hypersensitivity pneumonitis, pulmonary fibrosis and lung cancer were not significantly different from those in the normal controls. Prostaglandins F 35-38 latexin Homo sapiens 39-42 7129348-8 1982 But, higher values of PGF-MUM were contained in the pulmonary fibrosis group, and the values of PGF-MUM were correlated with the serum LDH levels (r= 0.652, P less than 0.01). Prostaglandins F 22-25 latexin Homo sapiens 26-29 7129348-8 1982 But, higher values of PGF-MUM were contained in the pulmonary fibrosis group, and the values of PGF-MUM were correlated with the serum LDH levels (r= 0.652, P less than 0.01). Prostaglandins F 96-99 latexin Homo sapiens 100-103 7315896-5 1981 In the myometrium the stimulatory effect of oxytocin on PGF production was small and not statistically significant, and PGE production was not affected at all. Prostaglandins F 56-59 oxytocin/neurophysin I prepropeptide Homo sapiens 44-52 6255881-2 1980 Isolated rings of human bronchioles contracted to histamine, carbachol, and prostaglandin F(2a)(PGF(2a)) and relaxed to isoproterenol. Prostaglandins F 76-91 placental growth factor Homo sapiens 96-99 7243104-5 1981 The production of prostaglandins F (PGF) and E (PGE) by the corpus luteum of the animals treated wit hCG was significantly lower than that of the controls (P less than .01). Prostaglandins F 18-34 hypertrichosis 2 (generalised, congenital) Homo sapiens 101-104 7243104-5 1981 The production of prostaglandins F (PGF) and E (PGE) by the corpus luteum of the animals treated wit hCG was significantly lower than that of the controls (P less than .01). Prostaglandins F 36-39 hypertrichosis 2 (generalised, congenital) Homo sapiens 101-104 7243104-6 1981 After hCG treatment, the decrease in PGF production was greater than that of PGE, resulting in a lower ratio of PGF:PGE production than in the controls (P less than .01). Prostaglandins F 37-40 hypertrichosis 2 (generalised, congenital) Homo sapiens 6-9 7243104-6 1981 After hCG treatment, the decrease in PGF production was greater than that of PGE, resulting in a lower ratio of PGF:PGE production than in the controls (P less than .01). Prostaglandins F 112-115 hypertrichosis 2 (generalised, congenital) Homo sapiens 6-9 6159206-10 1980 These results show that dog thyroid ODC is stimulated by TSH through cAMP, and suggest that cholinergic stimulation of the tissue blocks TSH activation of the enzyme, possibly at a step beyond cAMP synthesis, by increasing PGF synthesis. Prostaglandins F 223-226 ornithine decarboxylase 1 Canis lupus familiaris 36-39 7265982-10 1981 The decrease of renin synthesis by indomethacin must be provoked by the inhibition of an other substance than the PGE and PGF and 2) the role of PGE in renal haemodynamic and exocrine renal function seems to be important. Prostaglandins F 122-125 renin Canis lupus familiaris 16-21 7460481-8 1981 With no exception, there was a marked decrease in the PGF 2 alpha concentration in thrombin-stimulated PRP during therapy, and concentration was inversely correlated to the total plasma naproxen concentration. Prostaglandins F 54-57 coagulation factor II, thrombin Homo sapiens 83-91 580100-10 1977 4. tit was concluded that PGF 2 alpha could be administered most effectively by intravvenous drip infusion at 0.5 microgram/kg/min 3 times daily for 3 days after surgery for the satisfactory recovery from the postoperative ileus, and no appreciable side effect was observed. Prostaglandins F 26-29 CD59 molecule (CD59 blood group) Homo sapiens 127-132 7190721-3 1980 Although statistical significance was not present, net prostaglandin F release increased slightly from 8.6 to 13.9 ng/100 mg tissue. Prostaglandins F 55-70 ETS transcription factor ELK3 Homo sapiens 51-54 353256-7 1978 However, during insulin stimulation there was significantly more pepsin output per unit PGE or PGF output than during either pentagastrin or histamine stimulation. Prostaglandins F 95-98 insulin Homo sapiens 16-23 353256-9 1978 The correlations between the outputs of gastric acid and both PGE and PGF were similar during pentagastrin and insulin stimulation whereas those between acid and PGE and PGF altered during the infusion of histamine. Prostaglandins F 70-73 insulin Homo sapiens 111-118 37961-1 1979 1 Isolated lung parenchymal strips of the dog contracted in response to histamine > carbachol > prostaglandin F(2alpha) (PGF(2alpha)) > bradykinin (Bk) > 5-hydroxytryptamine (5-HT). Prostaglandins F 102-117 kininogen 1 Canis lupus familiaris 145-155 37961-1 1979 1 Isolated lung parenchymal strips of the dog contracted in response to histamine > carbachol > prostaglandin F(2alpha) (PGF(2alpha)) > bradykinin (Bk) > 5-hydroxytryptamine (5-HT). Prostaglandins F 127-130 kininogen 1 Canis lupus familiaris 145-155 893673-4 1977 In rats pregnant 20 days, prostaglandin F(2alpha) (PGF(2alpha)) increased the activity of lipoprotein lipase in mammary gland fourfold, reduced the activity in adipose tissue about 60%, and decreased serum concentration of triacylglycerol 50%. Prostaglandins F 26-41 lipoprotein lipase Rattus norvegicus 90-108 893673-4 1977 In rats pregnant 20 days, prostaglandin F(2alpha) (PGF(2alpha)) increased the activity of lipoprotein lipase in mammary gland fourfold, reduced the activity in adipose tissue about 60%, and decreased serum concentration of triacylglycerol 50%. Prostaglandins F 51-54 lipoprotein lipase Rattus norvegicus 90-108 893673-8 1977 Progesterone completely blocked the effects of PGF(2alpha) on lipoprotein lipase activity and serum triacylglycerol and prolactin concentrations. Prostaglandins F 47-50 lipoprotein lipase Rattus norvegicus 62-80 893673-9 1977 These findings indicate that the changes in lipoprotein lipase activity and serum triacylglycerol in PGF(2alpha)-treated rats are probably related to the inhibitory action of PGF(2alpha) on progesterone secretion. Prostaglandins F 101-104 lipoprotein lipase Rattus norvegicus 44-62 893673-9 1977 These findings indicate that the changes in lipoprotein lipase activity and serum triacylglycerol in PGF(2alpha)-treated rats are probably related to the inhibitory action of PGF(2alpha) on progesterone secretion. Prostaglandins F 175-178 lipoprotein lipase Rattus norvegicus 44-62 406936-5 1977 This may explain the finding that bradykinin induces the release of prostaglandin E compounds from arteries but prostaglandin F compounds from veins. Prostaglandins F 112-127 kininogen 1 Canis lupus familiaris 34-44 887800-1 1977 Generation of a prostaglandin of the F series by bovine mesenteric veins in response to bradykinin may depend on increased synthesis of PGE and conversion of the latter to PGF after activation of PGE 9-ketoreductase by the kinin. Prostaglandins F 172-175 kininogen 1 Bos taurus 88-98 887800-9 1977 Constriction of bovine mesenteric veins evoked by bradykinin may, therefore, depend on increased prostaglandin synthesis and conversion of newly formed PGE to PGF, both steps being affected by the kinin. Prostaglandins F 159-162 kininogen 1 Bos taurus 50-60 4794-3 1976 In agreement with published data, the 15-hydroxyprostaglandin dehydrogenase(s) derived from the kidney cortex were found to degrade all prostaglandins examined (PGE, PGF, PGA) in the presence of added cofactor NAD. Prostaglandins F 166-169 carbonyl reductase [NADPH] 1 Oryctolagus cuniculus 38-75 897785-0 1977 [Induction of labor with prostaglandin F 2alpha and its analog, 15-methyl-PGF 2alpha]. Prostaglandins F 25-40 placental growth factor Homo sapiens 74-77 817370-2 1976 Growth hormone (GH) release is stimulated by all eight PGs studied, PGE1 and E2 being 1000-fold more potent than the corresponding PGFs. Prostaglandins F 131-135 gonadotropin releasing hormone receptor Rattus norvegicus 0-14 186134-5 1976 Conversely PGF is capable of stimulating cyclic GMP which augments the processes listed above, and may therefore be termed pro-inflammatory. Prostaglandins F 11-14 5'-nucleotidase, cytosolic II Homo sapiens 48-51 183238-5 1976 Steroidogenic concentrations of ACTH (50-250muU) enhanced PGE and PGF release, and indomethacin suppressed the ACTH-facilitated release. Prostaglandins F 66-69 proopiomelanocortin Homo sapiens 32-36 817370-2 1976 Growth hormone (GH) release is stimulated by all eight PGs studied, PGE1 and E2 being 1000-fold more potent than the corresponding PGFs. Prostaglandins F 131-135 gonadotropin releasing hormone receptor Rattus norvegicus 16-18 817370-6 1976 PGFs do not affect the release of any of the measured pituitary hormones at concentrations below 10(-4)M. The stimulation of GH release by PGE2 can be inhibited by the PG antagonist 7-oxa-13-prostynoic acid, a half-maximal inhibition being found at a concentration of 4 X 10(-5)M of the antagonist in the presence of 10(-6)M PGE2. Prostaglandins F 0-4 gonadotropin releasing hormone receptor Rattus norvegicus 125-127 1197794-4 1975 Following PGF2alpha administration, plasma prolactin levels increased significantly only at 15 and 30 minutes in spite of extremely high PGF levels throughout 60 minutes. Prostaglandins F 10-13 prolactin Rattus norvegicus 43-52 1117220-0 1975 Proceedings: Effect of oxytocin on plasma prostaglandin F levels in the pregnant and post-partum ewe. Prostaglandins F 42-57 oxytocin/neurophysin I prepropeptide Homo sapiens 23-31 4547193-16 1974 Vasopressin causes a further increase in short circuit current in skins treated with prostaglandin F(1alpha). Prostaglandins F 85-100 arginine vasopressin Homo sapiens 0-11 32214217-1 2020 Preterm infants are increasingly diagnosed as having "extrauterine growth restriction" (EUGR) or "postnatal growth failure" (PGF). Prostaglandins F 125-128 placental growth factor Homo sapiens 97-123 4521806-6 1974 Furthermore, platelet aggregation induced by thrombin was accompanied by release of material reducible by stannous chloride into prostaglandin F(2alpha), thus indicating the involvement of endogenous prostaglandin endoperoxides in platelet aggregation. Prostaglandins F 129-144 coagulation factor II, thrombin Homo sapiens 45-53 4197607-4 1973 This apparent increase in (14)C incorporation into PGE(2) in the presence of EDTA could be due at least in part to its chelating properties of removing the divalent cations in the homogenate that enhance the selective formation of PGF(2alpha) and the suppression of the activity of epidermal phospholipase A, which causes the release of nonradioactive fatty acid precursors from endogenous phospholipids. Prostaglandins F 231-234 phospholipase A and acyltransferase 1 Homo sapiens 292-307 33599733-9 2021 Among several VEGFR1 ligands induced by hypoxia, placental growth factor (PlGF)/PGF alone upregulated galectin-1/LGALS1 expression via phosphorylation of activator protein 1 (AP-1) subunits following AKT and p38 mitogen-activated protein kinase (MAPK) activation. Prostaglandins F 80-83 fms related receptor tyrosine kinase 1 Homo sapiens 14-20 33599733-9 2021 Among several VEGFR1 ligands induced by hypoxia, placental growth factor (PlGF)/PGF alone upregulated galectin-1/LGALS1 expression via phosphorylation of activator protein 1 (AP-1) subunits following AKT and p38 mitogen-activated protein kinase (MAPK) activation. Prostaglandins F 80-83 galectin 1 Homo sapiens 102-112 33599733-9 2021 Among several VEGFR1 ligands induced by hypoxia, placental growth factor (PlGF)/PGF alone upregulated galectin-1/LGALS1 expression via phosphorylation of activator protein 1 (AP-1) subunits following AKT and p38 mitogen-activated protein kinase (MAPK) activation. Prostaglandins F 80-83 galectin 1 Homo sapiens 113-119 33599733-9 2021 Among several VEGFR1 ligands induced by hypoxia, placental growth factor (PlGF)/PGF alone upregulated galectin-1/LGALS1 expression via phosphorylation of activator protein 1 (AP-1) subunits following AKT and p38 mitogen-activated protein kinase (MAPK) activation. Prostaglandins F 80-83 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 154-173 33599733-9 2021 Among several VEGFR1 ligands induced by hypoxia, placental growth factor (PlGF)/PGF alone upregulated galectin-1/LGALS1 expression via phosphorylation of activator protein 1 (AP-1) subunits following AKT and p38 mitogen-activated protein kinase (MAPK) activation. Prostaglandins F 80-83 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 175-179 33599733-9 2021 Among several VEGFR1 ligands induced by hypoxia, placental growth factor (PlGF)/PGF alone upregulated galectin-1/LGALS1 expression via phosphorylation of activator protein 1 (AP-1) subunits following AKT and p38 mitogen-activated protein kinase (MAPK) activation. Prostaglandins F 80-83 AKT serine/threonine kinase 1 Homo sapiens 200-203 33599733-9 2021 Among several VEGFR1 ligands induced by hypoxia, placental growth factor (PlGF)/PGF alone upregulated galectin-1/LGALS1 expression via phosphorylation of activator protein 1 (AP-1) subunits following AKT and p38 mitogen-activated protein kinase (MAPK) activation. Prostaglandins F 80-83 mitogen-activated protein kinase 14 Homo sapiens 208-244 33599733-11 2021 PlGF application upregulated PGF expression via extracellular signal-regulated kinase 1 and 2, AKT, and p38 MAPK pathways. Prostaglandins F 29-32 placental growth factor Homo sapiens 0-4 33599733-11 2021 PlGF application upregulated PGF expression via extracellular signal-regulated kinase 1 and 2, AKT, and p38 MAPK pathways. Prostaglandins F 29-32 mitogen-activated protein kinase 3 Homo sapiens 48-93 33599733-11 2021 PlGF application upregulated PGF expression via extracellular signal-regulated kinase 1 and 2, AKT, and p38 MAPK pathways. Prostaglandins F 29-32 AKT serine/threonine kinase 1 Homo sapiens 95-98 31217073-4 2019 This study is the first to demonstrate that ASK-1 does not affect cell apoptosis and viability in ovarian cells, but promotes cell proliferation, suppresses p53, alters the release of ovarian hormones (P4, OT, IGF-I, PGF and PGE) and defines their response to the upstream hormonal regulators leptin and FSH. Prostaglandins F 217-220 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 44-49 32093661-1 2020 BACKGROUND: Prematurity is the leading cause of mortality in children under 5 years of age globally and is also frequently associated with postnatal growth failure (PGF). Prostaglandins F 165-168 placental growth factor Homo sapiens 139-163 31442830-1 2019 OBJECTIVES: Four isoforms originating from alternative splicing of PGF gene have been reported for placental growth factor (PlGF). Prostaglandins F 67-70 placental growth factor Homo sapiens 99-122 31442830-1 2019 OBJECTIVES: Four isoforms originating from alternative splicing of PGF gene have been reported for placental growth factor (PlGF). Prostaglandins F 67-70 placental growth factor Homo sapiens 124-128 31495738-4 2019 Transfection with the p53 cDNA construct resulted in the accumulation of p53 and bax, in a reduced level of released PCNA and PGF, and in an increased PGE output. Prostaglandins F 126-129 tumor protein p53 Homo sapiens 22-25 31015207-8 2019 Prophylactic NAC intervention was safe and effective in preventing the occurrence of PGF and PT in EC < 0.1% patients by promoting the dynamic reconstitution of BM ECs and CD34+ cells, along with reducing their ROS levels, which was further confirmed by in situ BM trephine biopsy analyses. Prostaglandins F 85-88 X-linked Kx blood group Homo sapiens 13-16 31243296-0 2019 Adult Pgf-/- mice behaviour and neuroanatomy are altered by neonatal treatment with recombinant placental growth factor. Prostaglandins F 6-9 placental growth factor Mus musculus 96-119 31243296-13 2019 Overall, neonatal PGF replacement altered behavior and neuroanatomy of adult Pgf-/- mice. Prostaglandins F 77-80 placental growth factor Mus musculus 18-21 30551399-14 2019 Moreover, up-regulation of miR-30e expression suppressed cytotoxicity, corresponding to increased expression of IL-4and IL-10 and reduced expression of IFN-gamma and TNF-alpha in PB-NK and D-NK cells, as well as enhanced expression of VEGF, Ang-2 and PGF in D-NK cells. Prostaglandins F 251-254 microRNA 30e Homo sapiens 27-34 31495738-6 2019 These observations are the first demonstration of the involvement of p53 in the control of healthy human ovarian cell functions, namely, in the downregulation of proliferation, in the upregulation of apoptosis, and in the alteration of PGF and PGE release, but not of P4, IGF-I, or OT. Prostaglandins F 236-239 tumor protein p53 Homo sapiens 69-72 30227197-3 2019 Considering the role of miRNAs in the regulation of gene expression, we computationally identified the miRNAs of two BLCLs, PGF and COX, predicted to interact with their corresponding DPB1 transcripts, DPB1 * 04:01:01:01-low expression and DPB1 * 03:01:01:01-high expression. Prostaglandins F 124-127 major histocompatibility complex, class II, DP beta 1 Homo sapiens 184-188 30599359-9 2019 Cx43 knockdown also resulted in up-regulated expressions of placental hormone (beta-hCG) and implantation related genes (LIFR, CDH5, LEP, PGF, TGFBR2). Prostaglandins F 138-141 gap junction protein alpha 1 Homo sapiens 0-4 30227197-3 2019 Considering the role of miRNAs in the regulation of gene expression, we computationally identified the miRNAs of two BLCLs, PGF and COX, predicted to interact with their corresponding DPB1 transcripts, DPB1 * 04:01:01:01-low expression and DPB1 * 03:01:01:01-high expression. Prostaglandins F 124-127 major histocompatibility complex, class II, DP beta 1 Homo sapiens 202-206 30227197-3 2019 Considering the role of miRNAs in the regulation of gene expression, we computationally identified the miRNAs of two BLCLs, PGF and COX, predicted to interact with their corresponding DPB1 transcripts, DPB1 * 04:01:01:01-low expression and DPB1 * 03:01:01:01-high expression. Prostaglandins F 124-127 major histocompatibility complex, class II, DP beta 1 Homo sapiens 202-206 30097186-10 2018 After PGF treatment on D 7, the expression of NR4A1-S increased which peaked at 0.5-1 h and then declined; while NR4A1-L expression did not change within 8 h. Real-time PCR results showed that the ovarian NR4A1 mRNA increased within 0.5 h, maintained high at 1 h and then declined. Prostaglandins F 6-9 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 46-51 30097186-10 2018 After PGF treatment on D 7, the expression of NR4A1-S increased which peaked at 0.5-1 h and then declined; while NR4A1-L expression did not change within 8 h. Real-time PCR results showed that the ovarian NR4A1 mRNA increased within 0.5 h, maintained high at 1 h and then declined. Prostaglandins F 6-9 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 113-118 30097186-10 2018 After PGF treatment on D 7, the expression of NR4A1-S increased which peaked at 0.5-1 h and then declined; while NR4A1-L expression did not change within 8 h. Real-time PCR results showed that the ovarian NR4A1 mRNA increased within 0.5 h, maintained high at 1 h and then declined. Prostaglandins F 6-9 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 113-118 30374328-10 2018 Endoplasmic reticulum (ER) stress signals including phosphorylation of inositol-requiring kinase1 (IRE1) and activation of X box binding protein (XBP-1) splicing were decreased by the PGF treatment. Prostaglandins F 184-187 X-box binding protein 1 Rattus norvegicus 146-151 30459003-10 2018 Further, correlation matrix with Spearman"s rho revealed that IL-8 had strong positive correlation with COX-2 and PGFS in the AP group (P < 0.05). Prostaglandins F 114-118 C-X-C motif chemokine ligand 8 Canis lupus familiaris 62-66 30374328-11 2018 Expressions of IRE1alpha, XBPs, and CHOP were all decreased by PGF. Prostaglandins F 63-66 DNA-damage inducible transcript 3 Rattus norvegicus 36-40 29449022-0 2018 Expression patterns of claudin-5 and its related signals during luteal regression in pseudopregnant rats: The enhanced effect of additional PGF treatment. Prostaglandins F 140-143 claudin 5 Rattus norvegicus 23-32 29933074-5 2018 Furthermore, increased intracellular reactive oxygen species, p-p53, and p21 (but not p38) levels were detected in MSCs from PGF patients. Prostaglandins F 125-128 tumor protein p53 Homo sapiens 64-67 29933074-5 2018 Furthermore, increased intracellular reactive oxygen species, p-p53, and p21 (but not p38) levels were detected in MSCs from PGF patients. Prostaglandins F 125-128 H3 histone pseudogene 16 Homo sapiens 73-76 29933074-6 2018 Moreover, the ability of MSCs to sustain hematopoiesis was significantly reduced in PGF patients, as evaluated by cell number, apoptosis, and the colony-forming unit-plating efficiency of CD34+ cells. Prostaglandins F 84-87 CD34 molecule Homo sapiens 188-192 29974948-8 2018 Furthermore, BM MFs from PGF patients with high tumour necrosis factor-alpha and interleukin 12 levels and low transforming growth factor-beta levels, led to impaired BM CD34+ cell function. Prostaglandins F 25-28 CD34 molecule Homo sapiens 170-174 30369204-1 2018 Objective: To evaluate the efficacy and safety of purified CD34(+) stem cell boost in the treatment of poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (HSCT) . Prostaglandins F 124-127 CD34 molecule Homo sapiens 59-63 30369204-8 2018 Conclusion: The infusion of donor purified CD34(+) stem cell was a safe and effective method for PGF after allogeneic HSCT. Prostaglandins F 97-100 CD34 molecule Homo sapiens 43-47 29633604-11 2018 Quantitative VEGF ELISA and RTPCR results indicated an increase in VEGF expression and secretion in the presence of PGF-2alpha. Prostaglandins F 116-119 vascular endothelial growth factor A Homo sapiens 13-17 29633604-11 2018 Quantitative VEGF ELISA and RTPCR results indicated an increase in VEGF expression and secretion in the presence of PGF-2alpha. Prostaglandins F 116-119 vascular endothelial growth factor A Homo sapiens 67-71 29633604-12 2018 The amount of VEGF produced in response to 0.1, 1.0, 2.5 and 5.0 mug/ml of PGF-2alpha was 62.4 +- 3.2 , 66.3 +- 3.7, 53.1 +- 2.6 and 49.0 +- 2.3 pg/ml, respectively, compared to the 35.2 +- 2.1 pg/ml produced by untreated cells. Prostaglandins F 75-78 vascular endothelial growth factor A Homo sapiens 14-18 29633604-13 2018 CONCLUSIONS: Stimulation of VEGF secretion by PGF-2alpha treated MSCs could be useful for the induction of angiogenesis in tissue engineering in vitro. Prostaglandins F 46-49 vascular endothelial growth factor A Homo sapiens 28-32 29449022-6 2018 Claudin-5 mRNA decreased at 4 h and 8 h after 1 PGF and 2 h after 2 PGF, and claudin-5 protein decreased at 4 h after 1 PGF. Prostaglandins F 48-51 claudin 5 Rattus norvegicus 0-9 29449022-6 2018 Claudin-5 mRNA decreased at 4 h and 8 h after 1 PGF and 2 h after 2 PGF, and claudin-5 protein decreased at 4 h after 1 PGF. Prostaglandins F 68-71 claudin 5 Rattus norvegicus 0-9 29449022-6 2018 Claudin-5 mRNA decreased at 4 h and 8 h after 1 PGF and 2 h after 2 PGF, and claudin-5 protein decreased at 4 h after 1 PGF. Prostaglandins F 68-71 claudin 5 Rattus norvegicus 0-9 29449022-7 2018 p-STAT3 increased at 4 h after 1 PGF and 2 h after 2 PGF. Prostaglandins F 33-36 signal transducer and activator of transcription 3 Rattus norvegicus 0-7 29449022-7 2018 p-STAT3 increased at 4 h after 1 PGF and 2 h after 2 PGF. Prostaglandins F 53-56 signal transducer and activator of transcription 3 Rattus norvegicus 0-7 29449022-8 2018 p-ERK increased at 2 h after 2 PGF. Prostaglandins F 31-34 Eph receptor B1 Rattus norvegicus 2-5 29449022-9 2018 The level of p-Akt decreased at 4 h after 1 PGF. Prostaglandins F 44-47 AKT serine/threonine kinase 1 Rattus norvegicus 13-18 29449022-11 2018 IHC results revealed that claudin-5 was expressed in the nuclei and cytoplasm of steroidogenic cells and in the vessels, while PGF induced-p-STAT3 was expressed uniformly in the cytoplasm of luteal steroidogenic cells. Prostaglandins F 127-130 signal transducer and activator of transcription 3 Rattus norvegicus 141-146 29449022-12 2018 In conclusion, PGF treatment decreased the expression of claudin-5 and the additional PGF treatment enhanced the decrease in claudin-5 mRNA expression and the increases in ERK1/2 and STAT3 phosphorylation in the corpus luteum of pseudopregnant rats, which will contribute new information to the further study of molecular mechanism of luteal regression. Prostaglandins F 15-18 claudin 5 Rattus norvegicus 57-66 29449022-12 2018 In conclusion, PGF treatment decreased the expression of claudin-5 and the additional PGF treatment enhanced the decrease in claudin-5 mRNA expression and the increases in ERK1/2 and STAT3 phosphorylation in the corpus luteum of pseudopregnant rats, which will contribute new information to the further study of molecular mechanism of luteal regression. Prostaglandins F 86-89 claudin 5 Rattus norvegicus 125-134 29449022-12 2018 In conclusion, PGF treatment decreased the expression of claudin-5 and the additional PGF treatment enhanced the decrease in claudin-5 mRNA expression and the increases in ERK1/2 and STAT3 phosphorylation in the corpus luteum of pseudopregnant rats, which will contribute new information to the further study of molecular mechanism of luteal regression. Prostaglandins F 86-89 mitogen activated protein kinase 3 Rattus norvegicus 172-178 29449022-12 2018 In conclusion, PGF treatment decreased the expression of claudin-5 and the additional PGF treatment enhanced the decrease in claudin-5 mRNA expression and the increases in ERK1/2 and STAT3 phosphorylation in the corpus luteum of pseudopregnant rats, which will contribute new information to the further study of molecular mechanism of luteal regression. Prostaglandins F 86-89 signal transducer and activator of transcription 3 Rattus norvegicus 183-188 29422826-1 2017 Introduction: It has been demonstrated that plasma growth factor (PGF) responsible for proliferation of smooth muscle cells and fibroblasts significantly shortens treatment duration. Prostaglandins F 66-69 placental growth factor Homo sapiens 44-64 29205259-2 2018 We report 50 paediatric patients with PGF who received 61 boosts with CD34+ selected peripheral blood stem cells (PBSC) after transplantation from matched unrelated (n = 25) or mismatched related (n = 25) donors. Prostaglandins F 38-41 CD34 molecule Homo sapiens 70-74 29487306-1 2018 Postnatal growth failure (PGF) in preterm infants remains an important clinical issue. Prostaglandins F 26-29 placental growth factor Homo sapiens 0-24 28323004-1 2017 CD34+-selected stem cell boost (SCB) without conditioning has recently been utilized for poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation with promising results. Prostaglandins F 110-113 CD34 molecule Homo sapiens 0-4 28323004-3 2017 Therefore, we conducted this study utilizing either fresh or cryopreserved peripheral blood stem cell products to create CD34+-selected boost infusions for the treatment of PGF. Prostaglandins F 173-176 CD34 molecule Homo sapiens 121-125 27169499-0 2017 Temporal regulation of extracellular signal-regulated kinase 1/2 phosphorylation, heat shock protein 70 and activating transcription factor 3 during prostaglandin F-induced luteal regression in pseudopregnant rats following heat stress. Prostaglandins F 149-164 mitogen activated protein kinase 3 Rattus norvegicus 23-62 27169499-0 2017 Temporal regulation of extracellular signal-regulated kinase 1/2 phosphorylation, heat shock protein 70 and activating transcription factor 3 during prostaglandin F-induced luteal regression in pseudopregnant rats following heat stress. Prostaglandins F 149-164 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 82-103 27169499-0 2017 Temporal regulation of extracellular signal-regulated kinase 1/2 phosphorylation, heat shock protein 70 and activating transcription factor 3 during prostaglandin F-induced luteal regression in pseudopregnant rats following heat stress. Prostaglandins F 149-164 activating transcription factor 3 Rattus norvegicus 108-141 27169499-1 2017 The aim of the present study was to investigate the effects of heat stress on heat shock protein (HSP) 70 expression and mitogen-activated protein kinase (MAPK) and protein kinase (PK) B signalling during prostaglandin F (PGF)-induced luteal regression. Prostaglandins F 205-220 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 139-153 27169499-1 2017 The aim of the present study was to investigate the effects of heat stress on heat shock protein (HSP) 70 expression and mitogen-activated protein kinase (MAPK) and protein kinase (PK) B signalling during prostaglandin F (PGF)-induced luteal regression. Prostaglandins F 205-220 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 165-179 27169499-1 2017 The aim of the present study was to investigate the effects of heat stress on heat shock protein (HSP) 70 expression and mitogen-activated protein kinase (MAPK) and protein kinase (PK) B signalling during prostaglandin F (PGF)-induced luteal regression. Prostaglandins F 205-220 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 157-159 27169499-1 2017 The aim of the present study was to investigate the effects of heat stress on heat shock protein (HSP) 70 expression and mitogen-activated protein kinase (MAPK) and protein kinase (PK) B signalling during prostaglandin F (PGF)-induced luteal regression. Prostaglandins F 222-225 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 78-105 27169499-4 2017 HSP70 expression in response to PGF was significantly enhanced in HS rats. Prostaglandins F 32-35 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 0-5 27169499-5 2017 PGF-induced phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 was significantly greater in the HS group; however, HS rats exhibited elevated basal levels of phosphorylation of p38 MAPK, but not ERK1/2. Prostaglandins F 0-3 mitogen activated protein kinase 3 Rattus norvegicus 31-78 27169499-5 2017 PGF-induced phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 was significantly greater in the HS group; however, HS rats exhibited elevated basal levels of phosphorylation of p38 MAPK, but not ERK1/2. Prostaglandins F 0-3 mitogen activated protein kinase 3 Rattus norvegicus 211-217 27169499-6 2017 PGF treatment increased expression of activating transcription factor (ATF) 3 at 2h, which was inhibited by heat stress. Prostaglandins F 0-3 activating transcription factor 3 Rattus norvegicus 38-77 27169499-8 2017 In conclusion, the present study provides further evidence that heat stress may enhance HSP70 and affect ERK1/2 and ATF3 expression, but not Akt activation, during PGF-induced luteal regression in pseudopregnant rats. Prostaglandins F 164-167 mitogen activated protein kinase 3 Rattus norvegicus 105-111 27169499-8 2017 In conclusion, the present study provides further evidence that heat stress may enhance HSP70 and affect ERK1/2 and ATF3 expression, but not Akt activation, during PGF-induced luteal regression in pseudopregnant rats. Prostaglandins F 164-167 activating transcription factor 3 Rattus norvegicus 116-120 27813716-9 2017 PGF around nonirradiated mini-implants showed higher levels of IL-8. Prostaglandins F 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 63-67 28333263-14 2017 PGE exerted similar effects to hCG-promoting genes, such as steroidogenic acute regulatory protein (STAR) and HSD3B1, to produce progesterone and luteotropic PGE, suppress PGF synthetic enzymes and down-regulate luteolytic molecules such as betaA- and betaB-inhibin subunits (INHBA and INHBB) and bone morphogenetic proteins (BMP2, BMP4 and BMP6). Prostaglandins F 172-175 steroidogenic acute regulatory protein Homo sapiens 100-104 28333263-14 2017 PGE exerted similar effects to hCG-promoting genes, such as steroidogenic acute regulatory protein (STAR) and HSD3B1, to produce progesterone and luteotropic PGE, suppress PGF synthetic enzymes and down-regulate luteolytic molecules such as betaA- and betaB-inhibin subunits (INHBA and INHBB) and bone morphogenetic proteins (BMP2, BMP4 and BMP6). Prostaglandins F 172-175 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 110-116 28515447-1 2017 The placental transcription factors Distal-less 3 (DLX3) and Glial cell missing-1 (GCM1) have been shown to coordinate the specific regulation of PGF in human trophoblast cell lines. Prostaglandins F 146-149 distal-less homeobox 3 Homo sapiens 51-55 28515447-1 2017 The placental transcription factors Distal-less 3 (DLX3) and Glial cell missing-1 (GCM1) have been shown to coordinate the specific regulation of PGF in human trophoblast cell lines. Prostaglandins F 146-149 glial cells missing transcription factor 1 Homo sapiens 61-81 28515447-1 2017 The placental transcription factors Distal-less 3 (DLX3) and Glial cell missing-1 (GCM1) have been shown to coordinate the specific regulation of PGF in human trophoblast cell lines. Prostaglandins F 146-149 glial cells missing transcription factor 1 Homo sapiens 83-87 28515447-5 2017 Studies revealed that DLX3 binding reduced the transcriptional activity of GCM1, providing a mechanistic explanation of their functional antagonism in regulating PGF promoter activity. Prostaglandins F 162-165 distal-less homeobox 3 Homo sapiens 22-26 28515447-5 2017 Studies revealed that DLX3 binding reduced the transcriptional activity of GCM1, providing a mechanistic explanation of their functional antagonism in regulating PGF promoter activity. Prostaglandins F 162-165 glial cells missing transcription factor 1 Homo sapiens 75-79 28333263-12 2017 MAIN RESULTS AND THE ROLE OF CHANCE: The key enzyme for PGE synthesis, PTGES mRNA was abundant in the functional CL during the mid-luteal phase (P < 0.01), while mRNA abundance for genes involved in PGF synthesis (AKR1B1 and AKR1C1-3) increased in the CL during the late-luteal phase and menstruation (P < 0.05-0.001). Prostaglandins F 202-205 prostaglandin E synthase Homo sapiens 71-76 28333263-14 2017 PGE exerted similar effects to hCG-promoting genes, such as steroidogenic acute regulatory protein (STAR) and HSD3B1, to produce progesterone and luteotropic PGE, suppress PGF synthetic enzymes and down-regulate luteolytic molecules such as betaA- and betaB-inhibin subunits (INHBA and INHBB) and bone morphogenetic proteins (BMP2, BMP4 and BMP6). Prostaglandins F 172-175 steroidogenic acute regulatory protein Homo sapiens 60-98 28292332-5 2017 RESULTS: A significantly higher proportion of stimulated CD4+ and CD8+ T cells that produced IL-17 (Th17 and Tc17) was found in the BM of PGF patients than in the BM of GGF patients and HD, whereas the percentages of Tregs in PGF patients were comparable to those in GGF patients and HD, resulting in a dramatically elevated ratio of Th17 cells/Tregs in the BM of PGF patients relative to those in GGF patients. Prostaglandins F 138-141 interleukin 17A Homo sapiens 93-98 28292332-5 2017 RESULTS: A significantly higher proportion of stimulated CD4+ and CD8+ T cells that produced IL-17 (Th17 and Tc17) was found in the BM of PGF patients than in the BM of GGF patients and HD, whereas the percentages of Tregs in PGF patients were comparable to those in GGF patients and HD, resulting in a dramatically elevated ratio of Th17 cells/Tregs in the BM of PGF patients relative to those in GGF patients. Prostaglandins F 226-229 interleukin 17A Homo sapiens 93-98 28292332-5 2017 RESULTS: A significantly higher proportion of stimulated CD4+ and CD8+ T cells that produced IL-17 (Th17 and Tc17) was found in the BM of PGF patients than in the BM of GGF patients and HD, whereas the percentages of Tregs in PGF patients were comparable to those in GGF patients and HD, resulting in a dramatically elevated ratio of Th17 cells/Tregs in the BM of PGF patients relative to those in GGF patients. Prostaglandins F 226-229 interleukin 17A Homo sapiens 93-98 27769957-8 2016 Activation of p38 and its downstream transcription factor cyclic adenosine monophosphate-responsive element-binding protein were detected in BM EPCs from subjects with PGF. Prostaglandins F 168-171 mitogen-activated protein kinase 14 Mus musculus 14-17 27769957-9 2016 Furthermore, the number and function of BM EPCs derived from subjects with PGF were enhanced by atorvastatin treatment in vitro through downregulation of the p38 MAPK pathway. Prostaglandins F 75-78 mitogen-activated protein kinase 14 Mus musculus 158-161 27641460-2 2016 Studying the crystal structure of human estrogen receptor alpha (hERalpha) and using nuclear magnetic resonance, we show here that the short V(364)PGF(367) sequence, which is located within its ligand-binding domain and adopts a type II beta-turn conformation in the protein, binds the peptidyl-prolyl isomerase (PPIase or rotamase) FK1 domain of FKBP52. Prostaglandins F 147-150 estrogen receptor 1 Homo sapiens 40-63 27641460-2 2016 Studying the crystal structure of human estrogen receptor alpha (hERalpha) and using nuclear magnetic resonance, we show here that the short V(364)PGF(367) sequence, which is located within its ligand-binding domain and adopts a type II beta-turn conformation in the protein, binds the peptidyl-prolyl isomerase (PPIase or rotamase) FK1 domain of FKBP52. Prostaglandins F 147-150 FKBP prolyl isomerase 4 Homo sapiens 313-319 27641460-2 2016 Studying the crystal structure of human estrogen receptor alpha (hERalpha) and using nuclear magnetic resonance, we show here that the short V(364)PGF(367) sequence, which is located within its ligand-binding domain and adopts a type II beta-turn conformation in the protein, binds the peptidyl-prolyl isomerase (PPIase or rotamase) FK1 domain of FKBP52. Prostaglandins F 147-150 FKBP prolyl isomerase 4 Homo sapiens 323-331 27641460-2 2016 Studying the crystal structure of human estrogen receptor alpha (hERalpha) and using nuclear magnetic resonance, we show here that the short V(364)PGF(367) sequence, which is located within its ligand-binding domain and adopts a type II beta-turn conformation in the protein, binds the peptidyl-prolyl isomerase (PPIase or rotamase) FK1 domain of FKBP52. Prostaglandins F 147-150 FKBP prolyl isomerase 4 Homo sapiens 347-353 27695456-5 2016 In situations of chronic inflammation complicating allo-HSCT, such as graft-versus-host disease or infections, PGF seems to be essentially the result of a sustained impairment of hematopoietic stem cells (HSC) self-renewal and proliferation caused by inflammatory mediators, such as interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha, and of induction of apoptosis through the Fas/Fas ligand pathway. Prostaglandins F 111-114 interferon gamma Homo sapiens 283-299 27695456-5 2016 In situations of chronic inflammation complicating allo-HSCT, such as graft-versus-host disease or infections, PGF seems to be essentially the result of a sustained impairment of hematopoietic stem cells (HSC) self-renewal and proliferation caused by inflammatory mediators, such as interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha, and of induction of apoptosis through the Fas/Fas ligand pathway. Prostaglandins F 111-114 tumor necrosis factor Homo sapiens 301-343 27695456-5 2016 In situations of chronic inflammation complicating allo-HSCT, such as graft-versus-host disease or infections, PGF seems to be essentially the result of a sustained impairment of hematopoietic stem cells (HSC) self-renewal and proliferation caused by inflammatory mediators, such as interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha, and of induction of apoptosis through the Fas/Fas ligand pathway. Prostaglandins F 111-114 Fas ligand Homo sapiens 391-401 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 CD4 molecule Homo sapiens 97-100 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 interferon gamma Homo sapiens 276-285 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 CD8a molecule Homo sapiens 108-111 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 interleukin 4 Homo sapiens 286-290 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 CD8a molecule Homo sapiens 363-366 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 interferon gamma Homo sapiens 137-146 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 negative elongation factor complex member C/D Homo sapiens 148-151 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 transcriptional and immune response regulator Homo sapiens 156-159 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 interleukin 4 Homo sapiens 204-208 27131864-6 2016 Relative to other subjects, patients with PGF had significantly higher proportions of stimulated CD4(+) and CD8(+) T cells that produced IFN-gamma (Th1 and Tc1 cells) but notably decreased proportions of IL-4-producing T cells (Th2 and Tc2 cells), resulting in a shift of the IFN-gamma/IL-4 ratio towards a type 1 response and an elevated percentage of activated CD8(+) T cells. Prostaglandins F 42-45 transcobalamin 2 Homo sapiens 236-239 26003810-5 2015 CCL2 was also down-regulated by luteotrophic prostaglandin (PG) E (P < 0.0001), but up-regulated by luteolytic PGF (P < 0.05) in vitro. Prostaglandins F 114-117 C-C motif chemokine ligand 2 Homo sapiens 0-4 27105530-6 2016 Using a prospective case-pair study, we identified increased levels of ROS in CD34+ bone marrow cells in subjects with PGF. Prostaglandins F 119-122 CD34 antigen Mus musculus 78-82 27105530-12 2016 Thus, even if the transplanted donors" bone marrow CD34+ cells are functionally normal pre-transplant, ROS-induced apoptosis may contribute to the exhaustion of CD34+ bone marrow cells in subjects with PGF following allotransplant. Prostaglandins F 202-205 CD34 antigen Mus musculus 161-165 26577839-6 2016 For ER- tumors, intronic SNPs PGF rs11542848 (OR = 1.38, 95% CI = 1.15-1.66) and rs61759375 (OR = 1.34, 95% CI = 1.14-1.57) and MAPK3 rs78564187 (OR = 1.26, 95% CI = 1.11-1.43) were associated with increased risk. Prostaglandins F 30-33 mitogen-activated protein kinase 3 Homo sapiens 128-133 26482178-4 2015 Moreover, LPA increased mPGES1 and cPGES and decreased PGFS expression in cultured bovine steroidogenic luteal cells. Prostaglandins F 55-59 plasminogen Bos taurus 10-13 25772027-7 2015 The use of tacrolimus-based immunosuppression and granulocyte colony-stimulating factor were associated with decreased PGF risk. Prostaglandins F 119-122 colony stimulating factor 3 Homo sapiens 50-87 25614048-1 2015 The current study was conducted to evaluate the expression of ATF3, in association with the activation of mitogen-activated protein kinases (MAPK) during prostaglandin F2alpha analog (PGF)-induced luteal regression in rats. Prostaglandins F 184-187 activating transcription factor 3 Rattus norvegicus 62-66 25614048-1 2015 The current study was conducted to evaluate the expression of ATF3, in association with the activation of mitogen-activated protein kinases (MAPK) during prostaglandin F2alpha analog (PGF)-induced luteal regression in rats. Prostaglandins F 184-187 mitogen activated protein kinase 3 Rattus norvegicus 141-145 25614048-5 2015 Western blot results revealed that ATF3 increased within 2h post-PGF injection. Prostaglandins F 65-68 activating transcription factor 3 Rattus norvegicus 35-39 25614048-6 2015 Phosphorylated ERK1/2 (p-ERK) and JNK (p-JNK) increased within 30min and then were gradually reduced in response to PGF. Prostaglandins F 116-119 mitogen activated protein kinase 3 Rattus norvegicus 15-21 25614048-6 2015 Phosphorylated ERK1/2 (p-ERK) and JNK (p-JNK) increased within 30min and then were gradually reduced in response to PGF. Prostaglandins F 116-119 mitogen-activated protein kinase 8 Rattus norvegicus 34-37 25614048-6 2015 Phosphorylated ERK1/2 (p-ERK) and JNK (p-JNK) increased within 30min and then were gradually reduced in response to PGF. Prostaglandins F 116-119 mitogen-activated protein kinase 8 Rattus norvegicus 39-44 25614048-9 2015 These results indicated that treatment with PGF in vivo could induce increases in MAPK phosphorylation, especially in p-ERK, which might be correlated with the increases in ATF3 expression and the decline in P4 concentrations. Prostaglandins F 44-47 mitogen activated protein kinase 3 Rattus norvegicus 82-86 25614048-9 2015 These results indicated that treatment with PGF in vivo could induce increases in MAPK phosphorylation, especially in p-ERK, which might be correlated with the increases in ATF3 expression and the decline in P4 concentrations. Prostaglandins F 44-47 activating transcription factor 3 Rattus norvegicus 173-177 25614048-10 2015 To our knowledge, this is the first study to provide evidence for temporal relationships between MAPK activation and ATF3 expression during PGF-induced luteal regression in the rat. Prostaglandins F 140-143 mitogen activated protein kinase 3 Rattus norvegicus 97-101 25614048-10 2015 To our knowledge, this is the first study to provide evidence for temporal relationships between MAPK activation and ATF3 expression during PGF-induced luteal regression in the rat. Prostaglandins F 140-143 activating transcription factor 3 Rattus norvegicus 117-121 25275481-7 2014 RESULTS: The apparent Km values for ABCC4-mediated transport were 2.9+-0.1 microM for PGE3, 12.1+-1.3 microM for PGF(3alpha), and 11.9+-1.4 microM for TXB3 and the ATP-dependent accumulation of PGE3, PGF(3alpha), and TXB3 into vesicles was decreased by using typical substrates and inhibitors of ABCC4. Prostaglandins F 113-116 ATP binding cassette subfamily C member 4 Homo sapiens 36-41 25426872-5 2015 Ucn2 was up-regulated by TNF-alpha via nuclear factor-kappaB (NF-kB) in myometrium cell lines (P < .05 or P < .01 on the basis of treatment doses) and increased proinflammatory mediators and prostaglandin F (PGF2alpha) receptor expression (P < .05) via CRH-R2, without a direct effect on contractility. Prostaglandins F 197-212 urocortin 2 Mus musculus 0-4 25325755-4 2014 This was mediated by the prostaglandin F(2alpha) (PGF(2alpha)), as inhibition of cyclooxygenases or PGF(2alpha) receptor signaling counteracted the AA-mediated aP2 induction. Prostaglandins F 25-40 prostaglandin F receptor Homo sapiens 100-120 25325755-4 2014 This was mediated by the prostaglandin F(2alpha) (PGF(2alpha)), as inhibition of cyclooxygenases or PGF(2alpha) receptor signaling counteracted the AA-mediated aP2 induction. Prostaglandins F 25-40 fatty acid binding protein 4 Homo sapiens 160-163 25325755-4 2014 This was mediated by the prostaglandin F(2alpha) (PGF(2alpha)), as inhibition of cyclooxygenases or PGF(2alpha) receptor signaling counteracted the AA-mediated aP2 induction. Prostaglandins F 50-53 prostaglandin F receptor Homo sapiens 100-120 25325755-4 2014 This was mediated by the prostaglandin F(2alpha) (PGF(2alpha)), as inhibition of cyclooxygenases or PGF(2alpha) receptor signaling counteracted the AA-mediated aP2 induction. Prostaglandins F 50-53 fatty acid binding protein 4 Homo sapiens 160-163 25275481-0 2014 Transport of eicosapentaenoic acid-derived PGE3, PGF(3alpha), and TXB3 by ABCC4. Prostaglandins F 49-52 ATP binding cassette subfamily C member 4 Homo sapiens 74-79 25275481-3 2014 We therefore investigated the contribution of ATP-binding cassette transporter C4 (ABCC4), which has been known as a prostanoids efflux transporter, to the release of PGE3, PGF(3alpha), and TXB3. Prostaglandins F 173-176 ATP binding cassette subfamily C member 4 Homo sapiens 46-81 25275481-3 2014 We therefore investigated the contribution of ATP-binding cassette transporter C4 (ABCC4), which has been known as a prostanoids efflux transporter, to the release of PGE3, PGF(3alpha), and TXB3. Prostaglandins F 173-176 ATP binding cassette subfamily C member 4 Homo sapiens 83-88 25275481-4 2014 MATERIALS AND METHODS: ATP-dependent transport of PGE3, PGF(3alpha), and TXB3 via ABCC4 was investigated by using inside-out membrane vesicles prepared from ABCC4-overexpressing HEK293 cells. Prostaglandins F 56-59 ATP binding cassette subfamily C member 4 Homo sapiens 82-87 25275481-7 2014 RESULTS: The apparent Km values for ABCC4-mediated transport were 2.9+-0.1 microM for PGE3, 12.1+-1.3 microM for PGF(3alpha), and 11.9+-1.4 microM for TXB3 and the ATP-dependent accumulation of PGE3, PGF(3alpha), and TXB3 into vesicles was decreased by using typical substrates and inhibitors of ABCC4. Prostaglandins F 113-116 ATP binding cassette subfamily C member 4 Homo sapiens 296-301 25275481-7 2014 RESULTS: The apparent Km values for ABCC4-mediated transport were 2.9+-0.1 microM for PGE3, 12.1+-1.3 microM for PGF(3alpha), and 11.9+-1.4 microM for TXB3 and the ATP-dependent accumulation of PGE3, PGF(3alpha), and TXB3 into vesicles was decreased by using typical substrates and inhibitors of ABCC4. Prostaglandins F 200-203 ATP binding cassette subfamily C member 4 Homo sapiens 36-41 25275481-8 2014 ABCC4 inhibitors and ABCC4 knockdown showed the reduction of extracellular/intracellular ratio of PGE3 (40-60% of control) and PGF(3alpha) (60-80% of control) in A549 cells. Prostaglandins F 127-130 ATP binding cassette subfamily C member 4 Homo sapiens 0-5 25275481-8 2014 ABCC4 inhibitors and ABCC4 knockdown showed the reduction of extracellular/intracellular ratio of PGE3 (40-60% of control) and PGF(3alpha) (60-80% of control) in A549 cells. Prostaglandins F 127-130 ATP binding cassette subfamily C member 4 Homo sapiens 21-26 25275481-9 2014 CONCLUSIONS: Our results suggest that PGE3, PGF(3alpha), and TXB3 are substrates of ABCC4 and ABCC4 partially contributes to the release of PGE3 and PGF(3alpha). Prostaglandins F 44-47 ATP binding cassette subfamily C member 4 Homo sapiens 84-89 25275481-9 2014 CONCLUSIONS: Our results suggest that PGE3, PGF(3alpha), and TXB3 are substrates of ABCC4 and ABCC4 partially contributes to the release of PGE3 and PGF(3alpha). Prostaglandins F 44-47 ATP binding cassette subfamily C member 4 Homo sapiens 94-99 25275481-9 2014 CONCLUSIONS: Our results suggest that PGE3, PGF(3alpha), and TXB3 are substrates of ABCC4 and ABCC4 partially contributes to the release of PGE3 and PGF(3alpha). Prostaglandins F 149-152 ATP binding cassette subfamily C member 4 Homo sapiens 84-89 25275481-9 2014 CONCLUSIONS: Our results suggest that PGE3, PGF(3alpha), and TXB3 are substrates of ABCC4 and ABCC4 partially contributes to the release of PGE3 and PGF(3alpha). Prostaglandins F 149-152 ATP binding cassette subfamily C member 4 Homo sapiens 94-99 24862637-2 2014 We report 41 patients with PGF, treated with granulocyte colony-stimulating factor-mobilized CD34 selected cells, at a median interval from transplant of 140 days, without conditioning and without GVHD prophylaxis. Prostaglandins F 27-30 colony stimulating factor 3 Homo sapiens 45-82 24862637-2 2014 We report 41 patients with PGF, treated with granulocyte colony-stimulating factor-mobilized CD34 selected cells, at a median interval from transplant of 140 days, without conditioning and without GVHD prophylaxis. Prostaglandins F 27-30 CD34 molecule Homo sapiens 93-97 24862637-8 2014 These data confirm the role of CD34(+) selected cells from the same donor in the treatment of PGF and warrant the request for a second donation also when the donor is unrelated. Prostaglandins F 94-97 CD34 molecule Homo sapiens 31-35 24480606-7 2014 Multivariate logistic regression models were constructed to evaluate the associations of VEGF and sFlt-1 on PGF, defined as weight <10th percentile at 36 weeks corrected age or discharge. Prostaglandins F 108-111 vascular endothelial growth factor A Homo sapiens 89-93 24913829-7 2014 RESULTS: In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen binding to AR suppressing c-MYC transcription, resulting in G0 arrest/terminal differentiation independent of Rb, p21, p27, FoxP3, or down regulation of growth factors receptors and instead involves androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which suppress c-MYC transcription. Prostaglandins F 39-42 androgen receptor Homo sapiens 107-109 24913829-7 2014 RESULTS: In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen binding to AR suppressing c-MYC transcription, resulting in G0 arrest/terminal differentiation independent of Rb, p21, p27, FoxP3, or down regulation of growth factors receptors and instead involves androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which suppress c-MYC transcription. Prostaglandins F 39-42 MYC proto-oncogene, bHLH transcription factor Homo sapiens 122-127 24913829-7 2014 RESULTS: In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen binding to AR suppressing c-MYC transcription, resulting in G0 arrest/terminal differentiation independent of Rb, p21, p27, FoxP3, or down regulation of growth factors receptors and instead involves androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which suppress c-MYC transcription. Prostaglandins F 39-42 H3 histone pseudogene 16 Homo sapiens 210-213 24913829-7 2014 RESULTS: In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen binding to AR suppressing c-MYC transcription, resulting in G0 arrest/terminal differentiation independent of Rb, p21, p27, FoxP3, or down regulation of growth factors receptors and instead involves androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which suppress c-MYC transcription. Prostaglandins F 39-42 interferon alpha inducible protein 27 Homo sapiens 215-218 24913829-7 2014 RESULTS: In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen binding to AR suppressing c-MYC transcription, resulting in G0 arrest/terminal differentiation independent of Rb, p21, p27, FoxP3, or down regulation of growth factors receptors and instead involves androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which suppress c-MYC transcription. Prostaglandins F 39-42 forkhead box P3 Homo sapiens 220-225 24913829-7 2014 RESULTS: In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen binding to AR suppressing c-MYC transcription, resulting in G0 arrest/terminal differentiation independent of Rb, p21, p27, FoxP3, or down regulation of growth factors receptors and instead involves androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which suppress c-MYC transcription. Prostaglandins F 39-42 catenin beta 1 Homo sapiens 328-340 24913829-7 2014 RESULTS: In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen binding to AR suppressing c-MYC transcription, resulting in G0 arrest/terminal differentiation independent of Rb, p21, p27, FoxP3, or down regulation of growth factors receptors and instead involves androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which suppress c-MYC transcription. Prostaglandins F 39-42 transcription factor 4 Homo sapiens 341-346 24913829-7 2014 RESULTS: In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen binding to AR suppressing c-MYC transcription, resulting in G0 arrest/terminal differentiation independent of Rb, p21, p27, FoxP3, or down regulation of growth factors receptors and instead involves androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which suppress c-MYC transcription. Prostaglandins F 39-42 MYC proto-oncogene, bHLH transcription factor Homo sapiens 373-378 24913829-9 2014 DISCUSSION: Proliferation of non-transformed human PrECs is dependent upon c-MYC transcription via formation/binding of beta-catenin/TCF-4 complexes at both 5" and 3" c-MYC enhancers stimulated by Wnt-independent, PGF induced Akt signaling. Prostaglandins F 214-217 MYC proto-oncogene, bHLH transcription factor Homo sapiens 75-80 24913829-9 2014 DISCUSSION: Proliferation of non-transformed human PrECs is dependent upon c-MYC transcription via formation/binding of beta-catenin/TCF-4 complexes at both 5" and 3" c-MYC enhancers stimulated by Wnt-independent, PGF induced Akt signaling. Prostaglandins F 214-217 transcription factor 4 Homo sapiens 133-138 24913829-10 2014 In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which retains binding to 3" c-MYC enhancer, but now suppresses c-MYC transcription. Prostaglandins F 30-33 catenin beta 1 Homo sapiens 111-123 24913829-10 2014 In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which retains binding to 3" c-MYC enhancer, but now suppresses c-MYC transcription. Prostaglandins F 30-33 transcription factor 4 Homo sapiens 124-129 24913829-10 2014 In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which retains binding to 3" c-MYC enhancer, but now suppresses c-MYC transcription. Prostaglandins F 30-33 MYC proto-oncogene, bHLH transcription factor Homo sapiens 169-174 24913829-10 2014 In the presence of continuous PGF signaling, PrEC hyperplasia is prevented by androgen-induced formation of AR/beta-catenin/TCF-4 complexes, which retains binding to 3" c-MYC enhancer, but now suppresses c-MYC transcription. Prostaglandins F 30-33 MYC proto-oncogene, bHLH transcription factor Homo sapiens 204-209 24480606-9 2014 Higher cord blood VEGF levels were associated with reduced risk of PGF (OR=0.7; 95% CI=0.5-0.9), while higher sFlt-1 levels appeared to increase the risk of PGF (OR=1.6; 95% CI=1.1-2.4). Prostaglandins F 67-70 vascular endothelial growth factor A Homo sapiens 18-22 24314160-1 2013 OBJECTIVE: To assess the efficacy and safety of recombinant human granulocyte colony stimulating factor (rhG-CSF) primed donor peripheral blood stem cell (PBSC) on the treatment of poor graft function (PGF) after allogeneic stem cell transplantation(allo-HSCT). Prostaglandins F 202-205 colony stimulating factor 3 Homo sapiens 66-103 24138077-14 2014 CONCLUSIONS AND IMPLICATIONS: P2Y14 receptors play a novel vasocontractile role in porcine pancreatic arteries, mediating contraction via cAMP-dependent mechanisms, elevation of intracellular Ca2+ levels, activation of RhoA/ROCK signalling and MLC2, along with release of TxA2, PGF(2alpha) and endothelin-1. Prostaglandins F 278-281 purinergic receptor P2Y14 Homo sapiens 30-35 24028822-10 2013 BMP-2-treatment increased the expression of ~30 factors by hASCs seeded on BCP, while it decreased the expression of only PGF, PPARG and PTN. Prostaglandins F 122-125 bone morphogenetic protein 2 Homo sapiens 0-5 24196350-6 2013 Real-time PCR and in situ hybridization showed that ATF3 mRNA increased within 1 hour of PGF treatment in vivo. Prostaglandins F 89-92 activating transcription factor 3 Bos taurus 52-56 24196350-8 2013 PGF treatment in vitro increased ATF3 expression only in LLC, whereas TNF induced ATF3 in both SLCs and LLCs. Prostaglandins F 0-3 activating transcription factor 3 Bos taurus 33-37 24156440-1 2013 This study was aimed to evaluate the efficacy and safety of donor"s purified CD34(+) cells for treatment of secondary poor graft function (PGF) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) . Prostaglandins F 139-142 CD34 molecule Homo sapiens 77-81 24333336-0 2014 Resveratrol suppresses prostaglandin F(2alpha)-induced osteoprotegerin synthesis in osteoblasts: inhibition of the MAP kinase signaling. Prostaglandins F 23-38 TNF receptor superfamily member 11b Homo sapiens 55-70 24196350-9 2013 PGF stimulated concentration- and time-dependent increases in ATF3 and phosphorylation of MAPKs in LLCs. Prostaglandins F 0-3 activating transcription factor 3 Bos taurus 62-66 24196350-12 2013 In conclusion, the action of PGF in LLCs is associated with the rapid activation of stress-activated protein kinases and the induction of ATF3, which may contribute to the reduction in steroid synthesis during luteal regression. Prostaglandins F 29-32 activating transcription factor 3 Bos taurus 138-142 23826817-2 2013 Atrial natriuretic peptide (ANP) has been found to reduce the IRI of cardiomyocytes and may be beneficial in alleviating PGF after heart transplantation, although there is a lack of evidence to support this issue. Prostaglandins F 121-124 natriuretic peptide A Rattus norvegicus 0-26 23089279-9 2013 However, PGF only induced JUN and JUND expression in CL with luteolytic capacity, a finding that may be key for understanding the acquisition of luteolytic capacity, given that JUN is the only AP-1 family member with strong N-terminal trans-activation activity. Prostaglandins F 9-12 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 34-38 23959730-2 2013 Additionally, we assessed whether the pronociceptive actions induced by intrathecally administered dynorphin A, cholecystokinin or prostaglandin F(2alpha) are mediated by the spinal TRPA1 channel. Prostaglandins F 131-146 transient receptor potential cation channel, subfamily A, member 1 Rattus norvegicus 182-187 23124680-0 2013 Alpha2-antiplasmin regulates the development of dermal fibrosis in mice by prostaglandin F(2alpha) synthesis through adipose triglyceride lipase/calcium-independent phospholipase A(2). Prostaglandins F 75-90 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 0-18 23124680-0 2013 Alpha2-antiplasmin regulates the development of dermal fibrosis in mice by prostaglandin F(2alpha) synthesis through adipose triglyceride lipase/calcium-independent phospholipase A(2). Prostaglandins F 75-90 patatin-like phospholipase domain containing 2 Mus musculus 118-145 23199747-10 2013 However, compared with mares treated with vehicle, the preovulatory follicle in the eLH and PGF(2alpha) groups had lower levels of androstenedione (P = 0.03) and higher levels of insulin-like growth factor I (P = 0.03). Prostaglandins F 92-95 insulin like growth factor 1 Equus caballus 179-207 23136298-7 2013 Transfection of primary amnion cells with SIRT6 siRNA was associated with an increase in IL-1beta-induced proinflammatory cytokine gene expression and release (IL6, IL8, TNF [TNF-alpha]), cyclooxygenase ([COX]-2; official symbol PTGS2) expression and subsequent prostaglandin (PGE(2) and PGF(2alpha)) release, and MMP9 gene expression and release of pro-MMP9. Prostaglandins F 288-291 sirtuin 6 Homo sapiens 42-47 23136298-7 2013 Transfection of primary amnion cells with SIRT6 siRNA was associated with an increase in IL-1beta-induced proinflammatory cytokine gene expression and release (IL6, IL8, TNF [TNF-alpha]), cyclooxygenase ([COX]-2; official symbol PTGS2) expression and subsequent prostaglandin (PGE(2) and PGF(2alpha)) release, and MMP9 gene expression and release of pro-MMP9. Prostaglandins F 288-291 interleukin 1 beta Homo sapiens 89-97 23321275-2 2013 PGF(2alpha) exerts its effects through PGF(2alpha) receptor (PTGFR), a G-protein-coupled receptor. Prostaglandins F 0-3 prostaglandin F receptor Homo sapiens 39-59 23321275-2 2013 PGF(2alpha) exerts its effects through PGF(2alpha) receptor (PTGFR), a G-protein-coupled receptor. Prostaglandins F 0-3 prostaglandin F receptor Homo sapiens 61-66 23321275-16 2013 Our results suggest para- and autocrine effects of PGF(2alpha) through its receptor PTGFR in the porcine endometrium, especially in luminal epithelium which is in direct contact with the conceptus during the implantation period. Prostaglandins F 51-54 prostaglandin F receptor Homo sapiens 84-89 23124680-8 2013 RESULTS: We found that alpha2AP binding to ATGL promoted PGF(2alpha) synthesis through iPLA(2) in fibroblasts, and the PGF(2alpha) synthesis that was promoted by alpha2AP induced TGFbeta production in fibroblasts. Prostaglandins F 57-60 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 23-31 23124680-8 2013 RESULTS: We found that alpha2AP binding to ATGL promoted PGF(2alpha) synthesis through iPLA(2) in fibroblasts, and the PGF(2alpha) synthesis that was promoted by alpha2AP induced TGFbeta production in fibroblasts. Prostaglandins F 57-60 patatin-like phospholipase domain containing 2 Mus musculus 43-47 23124680-8 2013 RESULTS: We found that alpha2AP binding to ATGL promoted PGF(2alpha) synthesis through iPLA(2) in fibroblasts, and the PGF(2alpha) synthesis that was promoted by alpha2AP induced TGFbeta production in fibroblasts. Prostaglandins F 119-122 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 23-31 23124680-8 2013 RESULTS: We found that alpha2AP binding to ATGL promoted PGF(2alpha) synthesis through iPLA(2) in fibroblasts, and the PGF(2alpha) synthesis that was promoted by alpha2AP induced TGFbeta production in fibroblasts. Prostaglandins F 119-122 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 162-170 23124680-9 2013 In addition, the neutralization of alpha2AP attenuated the production of TGFbeta and PGF(2alpha) in SSc-like fibroblasts from mice. Prostaglandins F 85-88 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 35-43 23124680-10 2013 The alpha2AP deficiency attenuated bleomycin-induced fibrosis and PGF(2alpha) synthesis, while the administration of PGF(2alpha) to alpha2AP-deficient mice facilitated alpha2AP deficiency-attenuated fibrosis. Prostaglandins F 66-69 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 4-12 23124680-10 2013 The alpha2AP deficiency attenuated bleomycin-induced fibrosis and PGF(2alpha) synthesis, while the administration of PGF(2alpha) to alpha2AP-deficient mice facilitated alpha2AP deficiency-attenuated fibrosis. Prostaglandins F 117-120 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 132-140 23124680-10 2013 The alpha2AP deficiency attenuated bleomycin-induced fibrosis and PGF(2alpha) synthesis, while the administration of PGF(2alpha) to alpha2AP-deficient mice facilitated alpha2AP deficiency-attenuated fibrosis. Prostaglandins F 117-120 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 132-140 23124680-11 2013 CONCLUSION: These findings suggest that alpha2AP regulates the development of fibrosis by PGF(2alpha) synthesis through ATGL/iPLA(2). Prostaglandins F 90-93 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 40-48 23124680-11 2013 CONCLUSION: These findings suggest that alpha2AP regulates the development of fibrosis by PGF(2alpha) synthesis through ATGL/iPLA(2). Prostaglandins F 90-93 patatin-like phospholipase domain containing 2 Mus musculus 120-124 23124680-11 2013 CONCLUSION: These findings suggest that alpha2AP regulates the development of fibrosis by PGF(2alpha) synthesis through ATGL/iPLA(2). Prostaglandins F 90-93 phospholipase A2, group VI Mus musculus 125-132 23043391-5 2013 Chemokine receptor mRNA expression was increased by stretch, reduced by oxytocin and PGF(2alpha) acting via phospholipase C (PLC). Prostaglandins F 85-88 C-X-C motif chemokine receptor 4 Homo sapiens 0-18 23043391-8 2013 CONCLUSION: These data show that myometrial chemokine receptor expression is reduced with the onset of term labour probably in response to the increased activity of chemokines, oxytocin and PGF(2alpha) . Prostaglandins F 190-193 C-X-C motif chemokine receptor 4 Homo sapiens 44-62 22959486-5 2012 After LPS and LTA stimulation, endometrial explants produced more PGF(2alpha) than PGE(2), which may be related to the early demise of the corpus luteum observed in vivo in canine pyometra cases. Prostaglandins F 66-69 lymphotoxin alpha Canis lupus familiaris 14-17 23064268-1 2012 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) among the MAP kinase superfamily in osteoblast-like MC3T3-E1 cells. Prostaglandins F 26-41 interleukin 6 Mus musculus 92-105 23064268-1 2012 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) among the MAP kinase superfamily in osteoblast-like MC3T3-E1 cells. Prostaglandins F 26-41 interleukin 6 Mus musculus 107-111 23064268-1 2012 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) among the MAP kinase superfamily in osteoblast-like MC3T3-E1 cells. Prostaglandins F 26-41 mitogen-activated protein kinase 3 Mus musculus 158-161 23064268-1 2012 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) among the MAP kinase superfamily in osteoblast-like MC3T3-E1 cells. Prostaglandins F 26-41 cyclin-dependent kinase 20 Mus musculus 162-165 23064268-1 2012 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) among the MAP kinase superfamily in osteoblast-like MC3T3-E1 cells. Prostaglandins F 26-41 mitogen-activated protein kinase 14 Mus musculus 209-212 23064268-1 2012 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) among the MAP kinase superfamily in osteoblast-like MC3T3-E1 cells. Prostaglandins F 51-54 interleukin 6 Mus musculus 92-105 23064268-1 2012 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) among the MAP kinase superfamily in osteoblast-like MC3T3-E1 cells. Prostaglandins F 51-54 interleukin 6 Mus musculus 107-111 23064268-1 2012 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) among the MAP kinase superfamily in osteoblast-like MC3T3-E1 cells. Prostaglandins F 51-54 mitogen-activated protein kinase 3 Mus musculus 158-161 23064268-1 2012 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) among the MAP kinase superfamily in osteoblast-like MC3T3-E1 cells. Prostaglandins F 51-54 cyclin-dependent kinase 20 Mus musculus 162-165 23064268-1 2012 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in part via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase but not stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) among the MAP kinase superfamily in osteoblast-like MC3T3-E1 cells. Prostaglandins F 51-54 mitogen-activated protein kinase 14 Mus musculus 209-212 23064268-2 2012 In the present study, we investigated the involvement of AMP-activated protein kinase (AMPK), an intracellular energy sensor, in PGF(2alpha)-stimulated IL-6 synthesis in MC3T3-E1 cells. Prostaglandins F 129-132 interleukin 6 Mus musculus 152-156 23064268-4 2012 Compound C, an inhibitor of AMPK, dose-dependently suppressed PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 62-65 interleukin 6 Mus musculus 85-89 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 13-16 interleukin 6 Homo sapiens 36-40 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 13-16 interleukin 6 Mus musculus 108-112 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 13-16 interleukin 6 Mus musculus 108-112 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 140-143 interleukin 6 Homo sapiens 36-40 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 140-143 interleukin 6 Mus musculus 108-112 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 140-143 interleukin 6 Mus musculus 108-112 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 140-143 interleukin 6 Homo sapiens 36-40 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 140-143 interleukin 6 Mus musculus 108-112 23064268-6 2012 In addition, PGF(2alpha)-stimulated IL-6 release in human osteoblasts was also inhibited by compound C. The IL-6 mRNA expression induced by PGF(2alpha) was markedly reduced by compound C. Downregulation of the AMPK alpha1-subunit by short interfering RNA (siRNA) significantly suppressed the PGF(2alpha)-stimulated IL-6 release. Prostaglandins F 140-143 interleukin 6 Mus musculus 108-112 23064268-7 2012 PGF(2alpha)-induced phosphorylation of p38 MAP kinase was inhibited by compound C, which failed to affect the p44/p42 MAP kinase phosphorylation. Prostaglandins F 0-3 mitogen-activated protein kinase 14 Mus musculus 39-42 23064268-8 2012 These results strongly suggest that AMPK regulates PGF(2alpha)-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts. Prostaglandins F 51-54 interleukin 6 Mus musculus 74-78 23064268-8 2012 These results strongly suggest that AMPK regulates PGF(2alpha)-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts. Prostaglandins F 51-54 mitogen-activated protein kinase 14 Mus musculus 93-96 23102844-5 2013 The objective of this study was to determine the activity of serum TK1 in dogs with pyometra and compare it with hematologic and biochemical parameters, e.g., acute phase proteins and inflammatory mediators such as C-reactive protein and Prostaglandin F(2alpha). Prostaglandins F 238-253 TK1 Canis lupus familiaris 67-70 22750649-6 2012 RESULT/CONCLUSION: The microarray experiments identified for the MCF7 cell line the genes MSH2 (p < 0.001), EREG (p < 0.001) and HSPA2 (p = 0.029) with CHH/CHG methylation, and in childhood ALL the genes HIST1H2AG (p = 0.003), PGF (p = 0.02), CPEB4 (p = 0.039) and TJP2 (p = 0.04). Prostaglandins F 233-236 mutS homolog 2 Homo sapiens 90-94 22962328-6 2012 IL-1beta treatment stimulated secretion of prostaglandin F(2alpha) from RAW 264.7 cells. Prostaglandins F 43-58 interleukin 1 beta Mus musculus 0-8 22962328-9 2012 CONCLUSIONS: These results suggest that IL-1beta-activated macrophages promote differentiation of human adipose tissue-derived mesenchymal stem cells to SMCs through a prostaglandin F(2alpha)-mediated paracrine mechanism. Prostaglandins F 168-183 interleukin 1 beta Homo sapiens 40-48 22750649-6 2012 RESULT/CONCLUSION: The microarray experiments identified for the MCF7 cell line the genes MSH2 (p < 0.001), EREG (p < 0.001) and HSPA2 (p = 0.029) with CHH/CHG methylation, and in childhood ALL the genes HIST1H2AG (p = 0.003), PGF (p = 0.02), CPEB4 (p = 0.039) and TJP2 (p = 0.04). Prostaglandins F 233-236 epiregulin Homo sapiens 111-115 22750649-6 2012 RESULT/CONCLUSION: The microarray experiments identified for the MCF7 cell line the genes MSH2 (p < 0.001), EREG (p < 0.001) and HSPA2 (p = 0.029) with CHH/CHG methylation, and in childhood ALL the genes HIST1H2AG (p = 0.003), PGF (p = 0.02), CPEB4 (p = 0.039) and TJP2 (p = 0.04). Prostaglandins F 233-236 heat shock protein family A (Hsp70) member 2 Homo sapiens 135-140 22769735-7 2012 RESULT(S): In IL-1beta-treated explants COX-2 mRNA and PGF(2alpha), concentrations were significantly down-regulated by CMA but not by DEX. Prostaglandins F 55-58 interleukin 1 beta Homo sapiens 14-22 22851578-3 2012 We previously reported that Akr1b7, an aldo-keto reductase enriched in adipose stromal vascular fraction but absent from mature adipocytes, has antiadipogenic properties possibly supported by PGF(2alpha) synthase activity. Prostaglandins F 192-195 aldo-keto reductase family 1, member B7 Mus musculus 28-34 22851578-7 2012 Akr1b7 loss was associated with decreased PGF(2alpha) WAT contents. Prostaglandins F 42-45 aldo-keto reductase family 1, member B7 Mus musculus 0-6 22851578-10 2012 Hence, Akr1b7 is a major regulator of WAT development through at least two PGF(2alpha)-dependent mechanisms: inhibition of adipogenesis and lipogenesis. Prostaglandins F 75-78 aldo-keto reductase family 1, member B7 Mus musculus 7-13 22583689-0 2012 The dietary fatty acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF(2alpha) synthesis in adipocytes. Prostaglandins F 88-91 cytochrome c oxidase II, mitochondrial Mus musculus 72-77 22583689-9 2012 However, PGF(2alpha), either exogenously or endogenously in response to 10E12Z-CLA, increased the expression of the potent mitogen and epidermal growth factor (EGF) receptor (EGFR) ligand epiregulin in 3T3-L1 adipocytes. Prostaglandins F 9-12 epidermal growth factor receptor Mus musculus 135-173 22583689-9 2012 However, PGF(2alpha), either exogenously or endogenously in response to 10E12Z-CLA, increased the expression of the potent mitogen and epidermal growth factor (EGF) receptor (EGFR) ligand epiregulin in 3T3-L1 adipocytes. Prostaglandins F 9-12 epidermal growth factor receptor Mus musculus 175-179 22583689-10 2012 Blocking PGF(2alpha) signaling with the PGF(2alpha) receptor (FP) antagonist AL-8810 returned epiregulin mRNA levels back to baseline. Prostaglandins F 9-12 prostaglandin F receptor Mus musculus 40-60 22486746-10 2012 The mRNA and protein expression of COX-2, along with production of PGE(2) and PGF(2alpha), are drastically raised by 2.5-5 mmol L(-1) TEGDMA. Prostaglandins F 78-81 mitochondrially encoded cytochrome c oxidase II Homo sapiens 35-40 22609937-8 2012 Double immunfluorescence staining revealed that PGF(2alpha)-immunopositive neurons expressed cytosolic phospholipases A(2), COX-2, and FP receptor. Prostaglandins F 48-51 cytochrome c oxidase II, mitochondrial Rattus norvegicus 124-129 22609937-9 2012 These results suggest that the major source of PGF(2alpha) production immediately after KA injection was neurons of the hippocampal CA3 sector, hilus and dentate gyrus. Prostaglandins F 47-50 carbonic anhydrase 3 Rattus norvegicus 132-135 22505406-1 2012 Rat aldose reductase-like protein (AKR1B14) is an orthologue of mouse vas deferens protein (AKR1B7) and plays roles in the detoxification of reactive aldehydes and synthesis of prostaglandin F(2alpha). Prostaglandins F 177-192 aldo-keto reductase family 1 member B Homo sapiens 4-20 22873350-7 2012 We obtained FLT1, VEGFA, FN1, F2 and PGF genes with the highest scores by hubs analysis; however, we also found other genes as PDIA3, LYN, SH2B2 and NDRG1 with high scores. Prostaglandins F 37-40 vascular endothelial growth factor A Homo sapiens 18-23 22873350-7 2012 We obtained FLT1, VEGFA, FN1, F2 and PGF genes with the highest scores by hubs analysis; however, we also found other genes as PDIA3, LYN, SH2B2 and NDRG1 with high scores. Prostaglandins F 37-40 LYN proto-oncogene, Src family tyrosine kinase Homo sapiens 134-137 22873350-7 2012 We obtained FLT1, VEGFA, FN1, F2 and PGF genes with the highest scores by hubs analysis; however, we also found other genes as PDIA3, LYN, SH2B2 and NDRG1 with high scores. Prostaglandins F 37-40 SH2B adaptor protein 2 Homo sapiens 139-144 22873350-7 2012 We obtained FLT1, VEGFA, FN1, F2 and PGF genes with the highest scores by hubs analysis; however, we also found other genes as PDIA3, LYN, SH2B2 and NDRG1 with high scores. Prostaglandins F 37-40 N-myc downstream regulated 1 Homo sapiens 149-154 22595111-9 2012 PGE(2) and PGF(2alpha) decreased the VCAM-1 expression and sVCAM-1 production of pulp cells. Prostaglandins F 11-14 vascular cell adhesion molecule 1 Homo sapiens 37-43 22595111-14 2012 PGE(2) and PGF(2alpha) may potentially regulate inflammatory processes by the inhibition of VCAM-1. Prostaglandins F 11-14 vascular cell adhesion molecule 1 Homo sapiens 92-98 22626779-13 2012 The hypothesis was supported that the synchrony of PGFM and PRL pulses represents a positive effect of PGF(2alpha) on PRL, rather than an effect of PRL on PGF(2alpha). Prostaglandins F 51-54 prolactin Homo sapiens 118-121 22626779-13 2012 The hypothesis was supported that the synchrony of PGFM and PRL pulses represents a positive effect of PGF(2alpha) on PRL, rather than an effect of PRL on PGF(2alpha). Prostaglandins F 51-54 prolactin Homo sapiens 118-121 22626779-13 2012 The hypothesis was supported that the synchrony of PGFM and PRL pulses represents a positive effect of PGF(2alpha) on PRL, rather than an effect of PRL on PGF(2alpha). Prostaglandins F 103-106 prolactin Homo sapiens 60-63 22626779-13 2012 The hypothesis was supported that the synchrony of PGFM and PRL pulses represents a positive effect of PGF(2alpha) on PRL, rather than an effect of PRL on PGF(2alpha). Prostaglandins F 103-106 prolactin Homo sapiens 118-121 22626779-13 2012 The hypothesis was supported that the synchrony of PGFM and PRL pulses represents a positive effect of PGF(2alpha) on PRL, rather than an effect of PRL on PGF(2alpha). Prostaglandins F 103-106 prolactin Homo sapiens 118-121 22654757-10 2012 The PGF synthase activity of AKR1B1 represents a new and important target to regulate ischemic and inflammatory responses associated with several human pathologies. Prostaglandins F 4-7 aldo-keto reductase family 1 member B Homo sapiens 29-35 22284221-2 2012 A pulse of PGF(2alpha), as indicated by a metabolite, was induced by E2 treatment on Day 15 (Day 0 = ovulation) and LH concentration was reduced with a GnRH-receptor antagonist (acyline) on Days 15, 16, and 17. Prostaglandins F 11-14 gonadotropin releasing hormone receptor Homo sapiens 152-165 22505406-1 2012 Rat aldose reductase-like protein (AKR1B14) is an orthologue of mouse vas deferens protein (AKR1B7) and plays roles in the detoxification of reactive aldehydes and synthesis of prostaglandin F(2alpha). Prostaglandins F 177-192 aldo-keto reductase family 1, member B7 Mus musculus 92-98 22367587-6 2012 VASH1 expression in the CL was constant through the early to late luteal phases and decreased during CL regression relating with the action of luteolytic prostaglandin F(2)(alpha) in vivo. Prostaglandins F 154-169 vasohibin 1 Bos taurus 0-5 22328559-8 2012 Treatment of endometrial epithelial cells with 100 nM PGE(2), PGF(2alpha) or hypoxia (0.5% O(2)) revealed a significant increase in CTGF mRNA expression (P < 0.01 for all, versus vehicle control). Prostaglandins F 62-65 cellular communication network factor 2 Homo sapiens 132-136 22291648-8 2011 AKR1C3 converts PGH(2) to PGF(2alpha) and PGD(2) to 9alpha,11beta-PGF(2). Prostaglandins F 26-29 aldo-keto reductase family 1 member C3 Homo sapiens 0-6 22410675-1 2012 Five primary prostanoids are synthesized by the cyclooxygenase enzymes, COX-1 and COX-2: the prostaglandins PGE(2), PGF(2alpha), PGI(2), PGD(2) and thromboxane A2. Prostaglandins F 116-119 mitochondrially encoded cytochrome c oxidase I Homo sapiens 72-77 22410675-1 2012 Five primary prostanoids are synthesized by the cyclooxygenase enzymes, COX-1 and COX-2: the prostaglandins PGE(2), PGF(2alpha), PGI(2), PGD(2) and thromboxane A2. Prostaglandins F 116-119 mitochondrially encoded cytochrome c oxidase II Homo sapiens 82-87 21951274-0 2012 Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2alpha) impairs endothelial function in renovascular hypertensive rats. Prostaglandins F 52-67 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 27-43 21951274-6 2012 Increased ROS production in RHR arteries was inhibited by ROS scavengers, but unaffected by COX-2 inhibitors; whereas increased PGF(2alpha) release was reduced by both ROS scavengers and COX-2 inhibitors. Prostaglandins F 128-131 cytochrome c oxidase II, mitochondrial Rattus norvegicus 187-192 21951274-7 2012 ROS also induced COX-2-dependent contraction in RHR renal arteries, which was accompanied by the release of COX-2-derived PGF(2alpha). Prostaglandins F 122-125 cytochrome c oxidase II, mitochondrial Rattus norvegicus 17-22 21951274-7 2012 ROS also induced COX-2-dependent contraction in RHR renal arteries, which was accompanied by the release of COX-2-derived PGF(2alpha). Prostaglandins F 122-125 cytochrome c oxidase II, mitochondrial Rattus norvegicus 108-113 21951274-9 2012 CONCLUSION: These findings demonstrate the functional importance of oxidative stress, which serves as an initiator of increased COX-2 activity, and that COX-2-derived PGF(2alpha) plays an important role in mediating endothelial dysfunction in RH. Prostaglandins F 167-170 cytochrome c oxidase II, mitochondrial Rattus norvegicus 153-158 21951274-10 2012 INNOVATION: The current study, thus, suggests that drugs targeting oxidative stress-dependent COX-2-derived PGF(2alpha) may be useful in the prevention and management of RH. Prostaglandins F 108-111 cytochrome c oxidase II, mitochondrial Rattus norvegicus 94-99 22291648-9 2011 AKR1B1 also reduces PGH(2) to PGF(2alpha), but does not form 9alpha,11beta-PGF(2). Prostaglandins F 30-33 aldo-keto reductase family 1 member B Homo sapiens 0-6 22050845-0 2012 Role of Trpc channels, Stim1 and Orai1 in PGF(2alpha)-induced calcium signaling in NRK fibroblasts. Prostaglandins F 42-45 ORAI calcium release-activated calcium modulator 1 Rattus norvegicus 33-38 21839801-8 2012 Visfatin significantly increased IL-6 and IL-8 gene expression and secretion, COX-2 expression and resultant prostaglandin (PG) E(2) and PGF(2alpha) release, and 8-isoprostane release. Prostaglandins F 137-140 nicotinamide phosphoribosyltransferase Homo sapiens 0-8 22050845-6 2012 Furthermore, our data show that knockdown of the genes encoding Trpc1, Orai1 and Stim1, but not Trpc6, substantially reduced the frequency (up to 60%) of PGF(2alpha)-induced Ca(2+) oscillations in NRK cells. Prostaglandins F 154-157 transient receptor potential cation channel, subfamily C, member 1 Rattus norvegicus 64-69 22050845-6 2012 Furthermore, our data show that knockdown of the genes encoding Trpc1, Orai1 and Stim1, but not Trpc6, substantially reduced the frequency (up to 60%) of PGF(2alpha)-induced Ca(2+) oscillations in NRK cells. Prostaglandins F 154-157 ORAI calcium release-activated calcium modulator 1 Rattus norvegicus 71-76 22050845-6 2012 Furthermore, our data show that knockdown of the genes encoding Trpc1, Orai1 and Stim1, but not Trpc6, substantially reduced the frequency (up to 60%) of PGF(2alpha)-induced Ca(2+) oscillations in NRK cells. Prostaglandins F 154-157 stromal interaction molecule 1 Rattus norvegicus 81-86 22186103-9 2012 In the early CL, TNF acted to increase P(4) and PGE(2) but decrease PGF(2alpha) secretion. Prostaglandins F 68-71 tumor necrosis factor Equus caballus 17-20 22186103-10 2012 In the mid luteal phase, TNF increased PGF(2alpha) secretion and TNF+IFNG decreased PGE(2) secretion. Prostaglandins F 39-42 tumor necrosis factor Equus caballus 25-28 22112832-7 2012 Knockdown of FoxO4 mRNA and protein in JEG-3 cells using siRNA was associated with decreased COX-2 mRNA expression concomitant with lower PGF(2alpha) secretion. Prostaglandins F 138-141 forkhead box O4 Homo sapiens 13-18 22970288-3 2012 In this study, we found that microsomal PGE(2) synthase (PGES)-1 (mPGES-1; PTGES1) acted as the PGES in adipocytes and that PGE(2) and PGF(2alpha) synergistically suppressed the early phase of adipogenesis. Prostaglandins F 135-138 prostaglandin E synthase Mus musculus 40-64 22970288-3 2012 In this study, we found that microsomal PGE(2) synthase (PGES)-1 (mPGES-1; PTGES1) acted as the PGES in adipocytes and that PGE(2) and PGF(2alpha) synergistically suppressed the early phase of adipogenesis. Prostaglandins F 135-138 prostaglandin E synthase Mus musculus 66-73 22970288-3 2012 In this study, we found that microsomal PGE(2) synthase (PGES)-1 (mPGES-1; PTGES1) acted as the PGES in adipocytes and that PGE(2) and PGF(2alpha) synergistically suppressed the early phase of adipogenesis. Prostaglandins F 135-138 prostaglandin E synthase Mus musculus 57-61 22235260-5 2012 PGF(2alpha) directly stimulated P-selectin protein expression at 5-30 min in luteal endothelial cells (LECs). Prostaglandins F 0-3 selectin P Bos taurus 32-42 22235260-6 2012 Moreover, PGF(2alpha) enhanced PMN adhesion to LECs, and this enhancement by PGF(2alpha) was inhibited by anti-P-selectin antibody, suggesting that P-selectin expression by PGF(2alpha) is crucial in PMN migration. Prostaglandins F 10-13 selectin P Bos taurus 111-121 22235260-6 2012 Moreover, PGF(2alpha) enhanced PMN adhesion to LECs, and this enhancement by PGF(2alpha) was inhibited by anti-P-selectin antibody, suggesting that P-selectin expression by PGF(2alpha) is crucial in PMN migration. Prostaglandins F 10-13 selectin P Bos taurus 148-158 22235260-6 2012 Moreover, PGF(2alpha) enhanced PMN adhesion to LECs, and this enhancement by PGF(2alpha) was inhibited by anti-P-selectin antibody, suggesting that P-selectin expression by PGF(2alpha) is crucial in PMN migration. Prostaglandins F 77-80 selectin P Bos taurus 111-121 22235260-6 2012 Moreover, PGF(2alpha) enhanced PMN adhesion to LECs, and this enhancement by PGF(2alpha) was inhibited by anti-P-selectin antibody, suggesting that P-selectin expression by PGF(2alpha) is crucial in PMN migration. Prostaglandins F 77-80 selectin P Bos taurus 148-158 22235260-6 2012 Moreover, PGF(2alpha) enhanced PMN adhesion to LECs, and this enhancement by PGF(2alpha) was inhibited by anti-P-selectin antibody, suggesting that P-selectin expression by PGF(2alpha) is crucial in PMN migration. Prostaglandins F 77-80 selectin P Bos taurus 111-121 22235260-6 2012 Moreover, PGF(2alpha) enhanced PMN adhesion to LECs, and this enhancement by PGF(2alpha) was inhibited by anti-P-selectin antibody, suggesting that P-selectin expression by PGF(2alpha) is crucial in PMN migration. Prostaglandins F 77-80 selectin P Bos taurus 148-158 22235260-7 2012 In conclusion, PGF(2alpha) rapidly induces the accumulation of PMNs into the bovine CL at 5 min and enhances PMN adhesion via P-selectin expression in LECs. Prostaglandins F 15-18 selectin P Bos taurus 126-136 22139184-1 2011 Aldo-keto reductase 1B3 (AKR1B3) catalyzes the NADPH-dependent reduction of prostaglandin H(2) (PGH(2)), which is a common intermediate of various prostanoids, to form PGF(2alpha). Prostaglandins F 168-171 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 0-23 22139184-1 2011 Aldo-keto reductase 1B3 (AKR1B3) catalyzes the NADPH-dependent reduction of prostaglandin H(2) (PGH(2)), which is a common intermediate of various prostanoids, to form PGF(2alpha). Prostaglandins F 168-171 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 25-31 22038018-5 2011 Increased levels of PGE(2) and PGF(2alpha) in premalignant and/or malignant epithelial skin cancers are due to the constitutive upregulation of enzymes involved in PG biosynthesis, such as COX-2, and downregulation of the tumor suppressor gene 15-hydroxy-prostaglandin dehydrogenase (15-PGDH), which is involved in the inactivation of PG, thus counteracting the activities of COX. Prostaglandins F 31-34 cytochrome c oxidase II, mitochondrial Mus musculus 189-194 22038018-5 2011 Increased levels of PGE(2) and PGF(2alpha) in premalignant and/or malignant epithelial skin cancers are due to the constitutive upregulation of enzymes involved in PG biosynthesis, such as COX-2, and downregulation of the tumor suppressor gene 15-hydroxy-prostaglandin dehydrogenase (15-PGDH), which is involved in the inactivation of PG, thus counteracting the activities of COX. Prostaglandins F 31-34 hydroxyprostaglandin dehydrogenase 15 (NAD) Mus musculus 244-282 22038018-5 2011 Increased levels of PGE(2) and PGF(2alpha) in premalignant and/or malignant epithelial skin cancers are due to the constitutive upregulation of enzymes involved in PG biosynthesis, such as COX-2, and downregulation of the tumor suppressor gene 15-hydroxy-prostaglandin dehydrogenase (15-PGDH), which is involved in the inactivation of PG, thus counteracting the activities of COX. Prostaglandins F 31-34 hydroxyprostaglandin dehydrogenase 15 (NAD) Mus musculus 284-291 21668646-1 2011 Prostaglandin (PG) F(2alpha) suppresses adipocyte differentiation by inhibiting the function of peroxisome proliferator-activated receptor gamma. Prostaglandins F 0-20 peroxisome proliferator activated receptor gamma Mus musculus 96-144 21996578-7 2011 p65/p65 enhanced the accumulation of PCNA, MAPK/ERK1,2 and Bax, the release of IGF-I, OT, PGE(2) and PGF(2alpha); decreased the percentage of cell containing TdT and did not affect the release of P(4). Prostaglandins F 101-104 proliferating cell nuclear antigen Homo sapiens 37-41 21996578-6 2011 We observed, that p50/p50 promoted the accumulation of PCNA, MAPK/ERK1,2, the release of OT, PGF(2alpha); inhibited the occurrence of TdT-positive cells, the release of IGF-I and P(4), and did not influence the accumulation of Bax and the release of PGE(2). Prostaglandins F 93-96 nuclear factor kappa B subunit 1 Homo sapiens 18-21 21996578-6 2011 We observed, that p50/p50 promoted the accumulation of PCNA, MAPK/ERK1,2, the release of OT, PGF(2alpha); inhibited the occurrence of TdT-positive cells, the release of IGF-I and P(4), and did not influence the accumulation of Bax and the release of PGE(2). Prostaglandins F 93-96 nuclear factor kappa B subunit 1 Homo sapiens 22-25 21996578-6 2011 We observed, that p50/p50 promoted the accumulation of PCNA, MAPK/ERK1,2, the release of OT, PGF(2alpha); inhibited the occurrence of TdT-positive cells, the release of IGF-I and P(4), and did not influence the accumulation of Bax and the release of PGE(2). Prostaglandins F 93-96 DNA nucleotidylexotransferase Homo sapiens 134-137 21996578-6 2011 We observed, that p50/p50 promoted the accumulation of PCNA, MAPK/ERK1,2, the release of OT, PGF(2alpha); inhibited the occurrence of TdT-positive cells, the release of IGF-I and P(4), and did not influence the accumulation of Bax and the release of PGE(2). Prostaglandins F 93-96 insulin like growth factor 1 Homo sapiens 169-174 21996578-7 2011 p65/p65 enhanced the accumulation of PCNA, MAPK/ERK1,2 and Bax, the release of IGF-I, OT, PGE(2) and PGF(2alpha); decreased the percentage of cell containing TdT and did not affect the release of P(4). Prostaglandins F 101-104 RELA proto-oncogene, NF-kB subunit Homo sapiens 0-3 21996578-7 2011 p65/p65 enhanced the accumulation of PCNA, MAPK/ERK1,2 and Bax, the release of IGF-I, OT, PGE(2) and PGF(2alpha); decreased the percentage of cell containing TdT and did not affect the release of P(4). Prostaglandins F 101-104 RELA proto-oncogene, NF-kB subunit Homo sapiens 4-7 21586312-1 2011 Aldo-keto reductase (AKR) 1B14, a rat ortholog of mouse androgen-dependent vas deferens protein (AKR1B7), is involved in the synthesis of prostaglandin F(2alpha) and detoxification of 4-oxononenal formed by lipid peroxidation. Prostaglandins F 138-153 aldo-keto reductase family 1, member B7 Mus musculus 97-103 21593476-9 2011 Furthermore, LC3-II expression increased, as did levels of cleaved caspase 3 in luteal cells cultured with prostaglandin F(2alpha) known to induce CL regression. Prostaglandins F 107-122 annexin A3 Rattus norvegicus 13-19 21801798-10 2011 Treatment of the cells with a specific p38 inhibitor (SB203580) or the antioxidant N-acetylcysteine (NAC) was able to prevent the toluene/benzene/styrene-dependent COX-2 activation, and subsequent increased PGE(2) and PGF(2alpha) secretion. Prostaglandins F 218-221 mitogen-activated protein kinase 14 Homo sapiens 39-42 21801798-11 2011 These results suggest that toluene, benzene and styrene induce production and secretion of PGE(2) and PGF(2alpha) in lung epithelial cells via p38 MAPK and COX-2 activation in a redox sensitive manner. Prostaglandins F 102-105 mitogen-activated protein kinase 14 Homo sapiens 143-146 21801798-11 2011 These results suggest that toluene, benzene and styrene induce production and secretion of PGE(2) and PGF(2alpha) in lung epithelial cells via p38 MAPK and COX-2 activation in a redox sensitive manner. Prostaglandins F 102-105 prostaglandin-endoperoxide synthase 2 Homo sapiens 156-161 21490242-3 2011 In the present study, we found that over a 12-h period following a single injection of prostaglandin F(2alpha) (PGF(2alpha)), RT-PCR revealed the upregulation of CYR61 at 0.5 and 1 h, after which it declined. Prostaglandins F 87-102 cellular communication network factor 1 Bos taurus 162-167 21490242-3 2011 In the present study, we found that over a 12-h period following a single injection of prostaglandin F(2alpha) (PGF(2alpha)), RT-PCR revealed the upregulation of CYR61 at 0.5 and 1 h, after which it declined. Prostaglandins F 112-115 cellular communication network factor 1 Bos taurus 162-167 21490242-5 2011 Treatment with PGF(2alpha) in vitro had no effect on CYR61 expression in luteal-derived endothelial cells, but it increased CYR61 expression in luteal steroidogenic cells. Prostaglandins F 15-18 cellular communication network factor 1 Bos taurus 124-129 21490242-7 2011 In addition, the specific but transient upregulation of CYR61 by PGF(2alpha) in vivo, and in luteal steroidogenic cells but not endothelial cells in vitro, may be part of the mechanism underlying the previously reported transient increase in blood flow during the early onset of luteolysis. Prostaglandins F 65-68 cellular communication network factor 1 Bos taurus 56-61 21490242-9 2011 Collectively, the increased expression of CYR61 in the Day 4 CL and its transient increase by PGF(2alpha) in Day 6, Day 10, and Day 16 CL indicate that CYR61 may play a role in regulating angiogenesis over the life span of the CL. Prostaglandins F 94-97 cellular communication network factor 1 Bos taurus 152-157 21668646-2 2011 In this study, we identified a novel suppression mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2alpha) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2alpha) -activated FP receptor/extracellular-signal-regulated kinase (ERK)/cyclic AMP response element binding protein (CREB) cascade. Prostaglandins F 155-158 cytochrome c oxidase II, mitochondrial Mus musculus 191-213 21668646-2 2011 In this study, we identified a novel suppression mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2alpha) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2alpha) -activated FP receptor/extracellular-signal-regulated kinase (ERK)/cyclic AMP response element binding protein (CREB) cascade. Prostaglandins F 155-158 mitogen-activated protein kinase 1 Mus musculus 311-314 21668646-2 2011 In this study, we identified a novel suppression mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2alpha) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2alpha) -activated FP receptor/extracellular-signal-regulated kinase (ERK)/cyclic AMP response element binding protein (CREB) cascade. Prostaglandins F 155-158 cAMP responsive element binding protein 1 Mus musculus 361-365 21668646-2 2011 In this study, we identified a novel suppression mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2alpha) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2alpha) -activated FP receptor/extracellular-signal-regulated kinase (ERK)/cyclic AMP response element binding protein (CREB) cascade. Prostaglandins F 237-240 cytochrome c oxidase II, mitochondrial Mus musculus 191-213 21668646-2 2011 In this study, we identified a novel suppression mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2alpha) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2alpha) -activated FP receptor/extracellular-signal-regulated kinase (ERK)/cyclic AMP response element binding protein (CREB) cascade. Prostaglandins F 237-240 mitogen-activated protein kinase 1 Mus musculus 311-314 21668646-2 2011 In this study, we identified a novel suppression mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2alpha) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2alpha) -activated FP receptor/extracellular-signal-regulated kinase (ERK)/cyclic AMP response element binding protein (CREB) cascade. Prostaglandins F 237-240 cAMP responsive element binding protein 1 Mus musculus 361-365 21668646-6 2011 Moreover, FP receptor mediated activation of the MEK/ERK cascade and COX-2 expression increased the production of PGF(2alpha) and PGE(2) . Prostaglandins F 114-117 midkine Mus musculus 49-52 21668646-6 2011 Moreover, FP receptor mediated activation of the MEK/ERK cascade and COX-2 expression increased the production of PGF(2alpha) and PGE(2) . Prostaglandins F 114-117 cytochrome c oxidase II, mitochondrial Mus musculus 69-74 21668646-7 2011 An FP receptor antagonist and each inhibitor for MEK and COX-2 suppressed the PGF(2alpha) -derived induction of synthesis of these PGs. Prostaglandins F 78-81 midkine Mus musculus 49-52 21668646-7 2011 An FP receptor antagonist and each inhibitor for MEK and COX-2 suppressed the PGF(2alpha) -derived induction of synthesis of these PGs. Prostaglandins F 78-81 cytochrome c oxidase II, mitochondrial Mus musculus 57-62 21668646-8 2011 Furthermore, promoter-luciferase and chromatin immunoprecipitation assays demonstrated that PGF(2alpha) -derived COX-2 expression was activated through binding of CREB to the promoter region of the COX-2 gene in 3T3-L1 cells. Prostaglandins F 92-95 cytochrome c oxidase II, mitochondrial Mus musculus 113-118 21668646-8 2011 Furthermore, promoter-luciferase and chromatin immunoprecipitation assays demonstrated that PGF(2alpha) -derived COX-2 expression was activated through binding of CREB to the promoter region of the COX-2 gene in 3T3-L1 cells. Prostaglandins F 92-95 cAMP responsive element binding protein 1 Mus musculus 163-167 21668646-8 2011 Furthermore, promoter-luciferase and chromatin immunoprecipitation assays demonstrated that PGF(2alpha) -derived COX-2 expression was activated through binding of CREB to the promoter region of the COX-2 gene in 3T3-L1 cells. Prostaglandins F 92-95 cytochrome c oxidase II, mitochondrial Mus musculus 198-203 21668646-9 2011 These results indicate that PGF(2alpha) suppresses the progression of the early phase of adipogenesis by enhancing the binding of CREB to the COX-2 promoter via FP receptor activated MEK/ERK cascade. Prostaglandins F 28-31 cAMP responsive element binding protein 1 Mus musculus 130-134 21668646-9 2011 These results indicate that PGF(2alpha) suppresses the progression of the early phase of adipogenesis by enhancing the binding of CREB to the COX-2 promoter via FP receptor activated MEK/ERK cascade. Prostaglandins F 28-31 cytochrome c oxidase II, mitochondrial Mus musculus 142-147 21668646-9 2011 These results indicate that PGF(2alpha) suppresses the progression of the early phase of adipogenesis by enhancing the binding of CREB to the COX-2 promoter via FP receptor activated MEK/ERK cascade. Prostaglandins F 28-31 midkine Mus musculus 183-186 21668646-9 2011 These results indicate that PGF(2alpha) suppresses the progression of the early phase of adipogenesis by enhancing the binding of CREB to the COX-2 promoter via FP receptor activated MEK/ERK cascade. Prostaglandins F 28-31 mitogen-activated protein kinase 1 Mus musculus 187-190 21677035-7 2011 VEGF was maximal when cells were cotreated with PGF(2alpha) and hypoxia simultaneously (P < 0.05-0.001). Prostaglandins F 48-51 vascular endothelial growth factor A Homo sapiens 0-4 21699992-1 2011 Cultured preadipocytes enhance the synthesis of prostaglandin (PG) E(2) and PGF(2alpha) involving the induction of cyclooxygenase (COX)-2 during the growth phase upon stimulation with a mixture of phorbol 12-myristate 13-acetate, a mitogenic factor, and calcium ionophore A23187. Prostaglandins F 76-79 mitochondrially encoded cytochrome c oxidase II Homo sapiens 115-137 21513769-4 2011 An up-regulation of COX-2 expression was demonstrated using qRT-PCR, western blot and immunofluorescence and increased production of PGF(2alpha) was demonstrated using LC/MS2 and enzyme immunoassay. Prostaglandins F 133-136 mitochondrially encoded cytochrome c oxidase II Homo sapiens 20-25 21474648-8 2011 Synthetic PGF(2alpha) and PGI(2) enhanced Th17 cell differentiation of COX-2(-/-) CD4(+) T cells in vitro. Prostaglandins F 10-13 cytochrome c oxidase II, mitochondrial Mus musculus 71-76 21474648-11 2011 CONCLUSIONS: COX-2 is a critical regulator of Th17 cell differentiation during allergic lung inflammation via autocrine signaling of PGI(2) and PGF(2alpha) through their respective cell surface receptors. Prostaglandins F 144-147 cytochrome c oxidase II, mitochondrial Mus musculus 13-18 21419570-8 2011 Moreover, phosphorylation of extracellular signal-regulated kinase (ERK) and induction of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), cyclin D1, and c-fos mRNA by PGE(2) were not observed in Ish-FuEP2/Ex2 and Ish-FuEP2/Ex2 culture medium-treated vector control cells, although they were found when treated with prostaglandin F(2alpha). Prostaglandins F 336-351 mitogen-activated protein kinase 1 Mus musculus 29-66 21419570-8 2011 Moreover, phosphorylation of extracellular signal-regulated kinase (ERK) and induction of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), cyclin D1, and c-fos mRNA by PGE(2) were not observed in Ish-FuEP2/Ex2 and Ish-FuEP2/Ex2 culture medium-treated vector control cells, although they were found when treated with prostaglandin F(2alpha). Prostaglandins F 336-351 mitogen-activated protein kinase 1 Mus musculus 68-71 21419570-8 2011 Moreover, phosphorylation of extracellular signal-regulated kinase (ERK) and induction of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), cyclin D1, and c-fos mRNA by PGE(2) were not observed in Ish-FuEP2/Ex2 and Ish-FuEP2/Ex2 culture medium-treated vector control cells, although they were found when treated with prostaglandin F(2alpha). Prostaglandins F 336-351 prostaglandin-endoperoxide synthase 2 Mus musculus 90-106 21420267-5 2011 The pretreatment of cells with P4 (progesterone), E2 (17 beta-estradiol), or E2/P4 augmented TNF-alpha-induced PGF(2alpha) and PGE2 secretion (P < 0.01). Prostaglandins F 111-114 dihydrolipoamide branched chain transacylase E2 Bos taurus 77-82 21420267-5 2011 The pretreatment of cells with P4 (progesterone), E2 (17 beta-estradiol), or E2/P4 augmented TNF-alpha-induced PGF(2alpha) and PGE2 secretion (P < 0.01). Prostaglandins F 111-114 tumor necrosis factor Bos taurus 93-102 21420267-6 2011 The pretreatment of cells with E2 or E2/P4 increased NONOate-induced PGF(2alpha) and PGE2 secretion (P < 0.01). Prostaglandins F 69-72 dihydrolipoamide branched chain transacylase E2 Bos taurus 37-42 21558311-15 2011 In the human endometrium, AM expression is up-regulated by two mechanisms: a HIF-1alpha-mediated hypoxic induction and a HIF-1alpha-independent PGF(2alpha) pathway. Prostaglandins F 144-147 adrenomedullin Homo sapiens 26-28 21236332-8 2011 Functional activity of Cox-2 expression was tested by measurement of PGE(2) and PGF(2alpha). Prostaglandins F 80-83 prostaglandin-endoperoxide synthase 2 Homo sapiens 23-28 21288684-1 2011 The effect of induction of parturition with a PGF(2)alpha analog on plasma concentration of prolactin (PRL) and its effects on colostrum concentration of IgG and chitotriosidase (ChT) activity were studied in 16 pregnant Majorera goats. Prostaglandins F 46-49 prolactin Capra hircus 92-101 21288684-1 2011 The effect of induction of parturition with a PGF(2)alpha analog on plasma concentration of prolactin (PRL) and its effects on colostrum concentration of IgG and chitotriosidase (ChT) activity were studied in 16 pregnant Majorera goats. Prostaglandins F 46-49 prolactin Capra hircus 103-106 20868664-12 2011 Activation of ERK1/2 contributes predominantly to transient endothelium-dependent contractions while JNKs, possibly synergistically with ERK1/2, leads to sustained PGF(2alpha)-induced contractions. Prostaglandins F 164-167 mitogen-activated protein kinase 3 Mus musculus 137-143 21306562-1 2011 Aldo-keto reductase 1B1 and 1B3 (AKR1B1 and AKR1B3) are the primary human and mouse prostaglandin F(2alpha) (PGF(2alpha)) synthases, respectively, which catalyze the NADPH-dependent reduction of PGH(2), a common intermediate of various prostanoids, to form PGF(2alpha). Prostaglandins F 84-99 aldo-keto reductase family 1 member B Homo sapiens 33-39 21306562-1 2011 Aldo-keto reductase 1B1 and 1B3 (AKR1B1 and AKR1B3) are the primary human and mouse prostaglandin F(2alpha) (PGF(2alpha)) synthases, respectively, which catalyze the NADPH-dependent reduction of PGH(2), a common intermediate of various prostanoids, to form PGF(2alpha). Prostaglandins F 109-112 aldo-keto reductase family 1 member B Homo sapiens 33-39 21306562-1 2011 Aldo-keto reductase 1B1 and 1B3 (AKR1B1 and AKR1B3) are the primary human and mouse prostaglandin F(2alpha) (PGF(2alpha)) synthases, respectively, which catalyze the NADPH-dependent reduction of PGH(2), a common intermediate of various prostanoids, to form PGF(2alpha). Prostaglandins F 257-260 aldo-keto reductase family 1 member B Homo sapiens 33-39 21306562-3 2011 Both PGD(2) and PGF(2alpha) synthase activities of AKR1B1 and AKR1B3 completely disappeared in the presence of NADP(+) or after heat treatment of these enzymes at 100 C for 5 min. Prostaglandins F 16-19 aldo-keto reductase family 1 member B Homo sapiens 51-57 21306562-5 2011 Site-directed mutagenesis of the catalytic tetrad of AKR1B1, composed of Tyr, Lys, His and Asp, revealed that the triad of Asp43, Lys77 and His110, but not Tyr48, acts as a proton donor in most AKR activities, and is crucial for PGD(2) and PGF(2alpha) synthase activities. Prostaglandins F 240-243 aldo-keto reductase family 1 member B Homo sapiens 53-59 21306562-6 2011 These results, together with molecular docking simulation of PGH(2) to the crystallographic structure of AKR1B1, indicate that His110 acts as a base in concert with Asp43 and Lys77 and as an acid to generate PGD(2) and PGF(2alpha) in the absence of NADPH or NADP(+) and in the presence of NADPH, respectively. Prostaglandins F 219-222 aldo-keto reductase family 1 member B Homo sapiens 105-111 21270323-10 2011 High-dose SP-A (100 mug/ml) inhibited PGF(2alpha) by term decidual stromal cells without affecting the production of other inflammatory mediators, and this effect occurred at a posttranscriptional level. Prostaglandins F 38-41 surfactant protein A1 Homo sapiens 10-14 21270323-13 2011 CONCLUSIONS: SP-A is produced by human endometrium/decidua, where it significantly and selectively inhibits PGF(2alpha) production. Prostaglandins F 108-111 surfactant protein A1 Homo sapiens 13-17 21236357-6 2011 These results indicate that niacin promoted adipogenesis by suppressing the production of the anti-adipogenic PGF(2alpha) through down-regulation of C/EBPbeta-activated cyclooxygenase-2 expression in adipocytes. Prostaglandins F 110-113 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 149-158 21191105-6 2011 PGF(2alpha) stimulated time- and dose-dependent increases in the phosphorylation of extracellular receptor kinase (ERK)1/2 (Thr202/Tyr204), p70S6 kinase (p70S6K) (Thr389 and Thr421/Ser424), and eukaryotic initiation factor 4G (eIF4G) (Ser1108) without influencing Akt (Ser473). Prostaglandins F 0-3 mitogen-activated protein kinase 3 Homo sapiens 84-122 21191105-6 2011 PGF(2alpha) stimulated time- and dose-dependent increases in the phosphorylation of extracellular receptor kinase (ERK)1/2 (Thr202/Tyr204), p70S6 kinase (p70S6K) (Thr389 and Thr421/Ser424), and eukaryotic initiation factor 4G (eIF4G) (Ser1108) without influencing Akt (Ser473). Prostaglandins F 0-3 ribosomal protein S6 kinase B1 Homo sapiens 140-152 21191105-6 2011 PGF(2alpha) stimulated time- and dose-dependent increases in the phosphorylation of extracellular receptor kinase (ERK)1/2 (Thr202/Tyr204), p70S6 kinase (p70S6K) (Thr389 and Thr421/Ser424), and eukaryotic initiation factor 4G (eIF4G) (Ser1108) without influencing Akt (Ser473). Prostaglandins F 0-3 ribosomal protein S6 kinase B1 Homo sapiens 154-160 21191105-6 2011 PGF(2alpha) stimulated time- and dose-dependent increases in the phosphorylation of extracellular receptor kinase (ERK)1/2 (Thr202/Tyr204), p70S6 kinase (p70S6K) (Thr389 and Thr421/Ser424), and eukaryotic initiation factor 4G (eIF4G) (Ser1108) without influencing Akt (Ser473). Prostaglandins F 0-3 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 194-225 21191105-6 2011 PGF(2alpha) stimulated time- and dose-dependent increases in the phosphorylation of extracellular receptor kinase (ERK)1/2 (Thr202/Tyr204), p70S6 kinase (p70S6K) (Thr389 and Thr421/Ser424), and eukaryotic initiation factor 4G (eIF4G) (Ser1108) without influencing Akt (Ser473). Prostaglandins F 0-3 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 227-232 21191105-6 2011 PGF(2alpha) stimulated time- and dose-dependent increases in the phosphorylation of extracellular receptor kinase (ERK)1/2 (Thr202/Tyr204), p70S6 kinase (p70S6K) (Thr389 and Thr421/Ser424), and eukaryotic initiation factor 4G (eIF4G) (Ser1108) without influencing Akt (Ser473). Prostaglandins F 0-3 AKT serine/threonine kinase 1 Homo sapiens 264-267 21112968-5 2011 The expression profiles of the PGF(2alpha) synthases identified AKR1B1 and CBR1 as the likely regulators of PGF(2alpha) production during the menstrual phase. Prostaglandins F 31-34 aldo-keto reductase family 1 member B Homo sapiens 64-70 21264946-7 2011 Our data show dynamic changes of PlGF expression, from periaxonal in normal nerve to SCs 24h postinjury, in parallel with a p65/NF-kappaB recruitment on Pgf promoter. Prostaglandins F 153-156 placental growth factor Mus musculus 33-37 21264946-7 2011 Our data show dynamic changes of PlGF expression, from periaxonal in normal nerve to SCs 24h postinjury, in parallel with a p65/NF-kappaB recruitment on Pgf promoter. Prostaglandins F 153-156 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-137 21264946-10 2011 MCP-1 and proMMP-9 exhibit a 3-fold reduction of their relative expressions in Pgf(-/-) injured nerves, as demonstrated by cytokine array. Prostaglandins F 79-82 mast cell protease 1 Mus musculus 0-5 21112968-5 2011 The expression profiles of the PGF(2alpha) synthases identified AKR1B1 and CBR1 as the likely regulators of PGF(2alpha) production during the menstrual phase. Prostaglandins F 31-34 carbonyl reductase 1 Homo sapiens 75-79 21112968-5 2011 The expression profiles of the PGF(2alpha) synthases identified AKR1B1 and CBR1 as the likely regulators of PGF(2alpha) production during the menstrual phase. Prostaglandins F 108-111 aldo-keto reductase family 1 member B Homo sapiens 64-70 21112968-5 2011 The expression profiles of the PGF(2alpha) synthases identified AKR1B1 and CBR1 as the likely regulators of PGF(2alpha) production during the menstrual phase. Prostaglandins F 108-111 carbonyl reductase 1 Homo sapiens 75-79 21109016-4 2011 Prostaglandin F(2alpha) is synthesized from arachidonic acid, which is released from phospholipids by phospholipase A2. Prostaglandins F 0-15 LOC104974671 Bos taurus 102-118 20844277-10 2011 The SIRT1 activators resveratrol and SRT1720 significantly decreased LPS-induced TNF, IL6, and IL8 gene expression and release and PTGS2 mRNA expression and resultant prostaglandin (PG) E(2) and PGF(2alpha) release from human gestational tissues. Prostaglandins F 195-198 sirtuin 1 Homo sapiens 4-9 21168333-1 2011 Rat aldose reductase-like protein (AKR1B14) is the ortholog of mouse vas deferens protein (AKR1B7) playing roles in detoxification of reactive aldehydes and synthesis of prostaglandin F(2alpha). Prostaglandins F 170-185 aldo-keto reductase family 1, member B7 Rattus norvegicus 35-42 21168333-1 2011 Rat aldose reductase-like protein (AKR1B14) is the ortholog of mouse vas deferens protein (AKR1B7) playing roles in detoxification of reactive aldehydes and synthesis of prostaglandin F(2alpha). Prostaglandins F 170-185 aldo-keto reductase family 1, member B7 Mus musculus 91-97 20962043-5 2010 We hypothesize that modulation in the endometrial pulsatile vs. basal release of PGF(2alpha) likely requires PGT-mediated selective transport, and IFNT interacts with PGT protein and modulates pulsatile vs. basal release of PGF(2alpha). Prostaglandins F 224-227 solute carrier organic anion transporter family member 2A1 Ovis aries 167-170 20720169-8 2010 FASL clearly inhibited in vitro progesterone and prostaglandin E(2) (PGE(2)) production by equine luteal cells but increased prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 125-140 Fas ligand Equus caballus 0-4 20720169-8 2010 FASL clearly inhibited in vitro progesterone and prostaglandin E(2) (PGE(2)) production by equine luteal cells but increased prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 150-153 Fas ligand Equus caballus 0-4 20868682-1 2010 We investigated the effects of prostaglandin F(2alpha) (PGF(2alpha)) analogues on the endothelin-1 (ET-1)-induced impairment of optic nerve head (ONH) blood flow and on ET-1-induced contraction in isolated ciliary artery segments. Prostaglandins F 31-46 endothelin-1 Oryctolagus cuniculus 86-98 20868682-1 2010 We investigated the effects of prostaglandin F(2alpha) (PGF(2alpha)) analogues on the endothelin-1 (ET-1)-induced impairment of optic nerve head (ONH) blood flow and on ET-1-induced contraction in isolated ciliary artery segments. Prostaglandins F 56-59 endothelin-1 Oryctolagus cuniculus 86-98 20868682-8 2010 In vitro, the effects of PGF(2alpha) analogues on ET-1-induced contractions in male rabbit ciliary arteries were evaluated using an isometric tension recording system. Prostaglandins F 25-28 endothelin-1 Oryctolagus cuniculus 50-54 21094738-9 2010 Heifers that were not pregnant to first TAI had greater expression of Oas1 at the time of PGF(2alpha) (d -3) than pregnant heifers, but this relationship was reversed on d 18 after TAI: the heifers that were pregnant to first TAI had almost 5-fold greater expression of Oas1 compared with nonpregnant heifers. Prostaglandins F 90-93 2',5'-oligoadenylate synthetase 1 Bos taurus 70-74 20962043-4 2010 We have recently found that pulsatile release of PGF(2alpha) from the endometrium is regulated by prostaglandin transporter (PGT)-mediated mechanisms. Prostaglandins F 49-52 solute carrier organic anion transporter family member 2A1 Ovis aries 98-123 20962043-4 2010 We have recently found that pulsatile release of PGF(2alpha) from the endometrium is regulated by prostaglandin transporter (PGT)-mediated mechanisms. Prostaglandins F 49-52 solute carrier organic anion transporter family member 2A1 Ovis aries 125-128 19645858-9 2010 Leukotriene C(4) inhibited P4 secretion at the mid- and regressing-luteal stage, stimulated NO (entire cycle) and PGF(2alpha) at mid- and regressing-luteal phases. Prostaglandins F 114-117 complement C4 Bos taurus 12-16 21264946-10 2011 MCP-1 and proMMP-9 exhibit a 3-fold reduction of their relative expressions in Pgf(-/-) injured nerves, as demonstrated by cytokine array. Prostaglandins F 79-82 matrix metallopeptidase 9 Mus musculus 10-18 20816914-0 2011 Chemokine (C-C) motif ligand 20 is regulated by PGF(2alpha)-F-prostanoid receptor signalling in endometrial adenocarcinoma and promotes cell proliferation. Prostaglandins F 48-51 C-C motif chemokine ligand 20 Homo sapiens 0-31 20816914-3 2011 In this study, the expression of the chemokine CC motif Ligand 20 (CCL20) was determined to be regulated by PGF(2alpha)-FP receptor signalling in endometrial adenocarcinoma explants and cell line, and expression of CCL20 and its receptor CCR6 was elevated in endometrial adenocarcinoma compared to non-malignant endometrium. Prostaglandins F 108-111 C-C motif chemokine ligand 20 Homo sapiens 47-65 20816914-3 2011 In this study, the expression of the chemokine CC motif Ligand 20 (CCL20) was determined to be regulated by PGF(2alpha)-FP receptor signalling in endometrial adenocarcinoma explants and cell line, and expression of CCL20 and its receptor CCR6 was elevated in endometrial adenocarcinoma compared to non-malignant endometrium. Prostaglandins F 108-111 C-C motif chemokine ligand 20 Homo sapiens 67-72 20816914-3 2011 In this study, the expression of the chemokine CC motif Ligand 20 (CCL20) was determined to be regulated by PGF(2alpha)-FP receptor signalling in endometrial adenocarcinoma explants and cell line, and expression of CCL20 and its receptor CCR6 was elevated in endometrial adenocarcinoma compared to non-malignant endometrium. Prostaglandins F 108-111 C-C motif chemokine ligand 20 Homo sapiens 215-220 20816914-3 2011 In this study, the expression of the chemokine CC motif Ligand 20 (CCL20) was determined to be regulated by PGF(2alpha)-FP receptor signalling in endometrial adenocarcinoma explants and cell line, and expression of CCL20 and its receptor CCR6 was elevated in endometrial adenocarcinoma compared to non-malignant endometrium. Prostaglandins F 108-111 C-C motif chemokine receptor 6 Homo sapiens 238-242 20816914-5 2011 The induction of CCL20 expression by PGF(2alpha)-FP signalling in an endometrial adenocarcinoma cell line stably expressing the FP receptor (FPS cells) was found to be dependent on the intracellular signalling of Gq, EGFR, ERK, calcineurin and nuclear factor of activated T-cells (NFAT) proteins. Prostaglandins F 37-40 C-C motif chemokine ligand 20 Homo sapiens 17-22 20816914-5 2011 The induction of CCL20 expression by PGF(2alpha)-FP signalling in an endometrial adenocarcinoma cell line stably expressing the FP receptor (FPS cells) was found to be dependent on the intracellular signalling of Gq, EGFR, ERK, calcineurin and nuclear factor of activated T-cells (NFAT) proteins. Prostaglandins F 37-40 epidermal growth factor receptor Homo sapiens 217-221 20816914-5 2011 The induction of CCL20 expression by PGF(2alpha)-FP signalling in an endometrial adenocarcinoma cell line stably expressing the FP receptor (FPS cells) was found to be dependent on the intracellular signalling of Gq, EGFR, ERK, calcineurin and nuclear factor of activated T-cells (NFAT) proteins. Prostaglandins F 37-40 mitogen-activated protein kinase 1 Homo sapiens 223-226 21791181-7 2011 This significant elevation in Ifitm1 gene expression at post partum stage was identical to Ifitm1 expression after the induction of abortion by injection of prostaglandin F(2alpha). Prostaglandins F 157-172 interferon induced transmembrane protein 1 Mus musculus 30-36 21791181-7 2011 This significant elevation in Ifitm1 gene expression at post partum stage was identical to Ifitm1 expression after the induction of abortion by injection of prostaglandin F(2alpha). Prostaglandins F 157-172 interferon induced transmembrane protein 1 Mus musculus 91-97 22127001-4 2011 Cyclooxygenase-2 has therefore been suggested as one of the regulators of endometrial prostaglandin F(2alpha) release modified by the antiluteolytic factor secreted by the conceptus. Prostaglandins F 86-101 prostaglandin-endoperoxide synthase 2 Equus caballus 0-16 20962043-7 2010 The results of the present study provide important new insights on IFNT signaling and molecular control of PGT-mediated release of PGF(2alpha) and unravel the underlying mechanisms responsible for the increased basal release of PGF(2alpha) at the time of establishment of pregnancy in ruminants. Prostaglandins F 131-134 solute carrier organic anion transporter family member 2A1 Ovis aries 107-110 20962043-7 2010 The results of the present study provide important new insights on IFNT signaling and molecular control of PGT-mediated release of PGF(2alpha) and unravel the underlying mechanisms responsible for the increased basal release of PGF(2alpha) at the time of establishment of pregnancy in ruminants. Prostaglandins F 228-231 solute carrier organic anion transporter family member 2A1 Ovis aries 107-110 21151654-3 2010 Group 2 (PGF + GnRH; n = 13) received an injection of GnRH (100 mug, im) immediately after an injection of PGF(2alpha). Prostaglandins F 9-12 gonadotropin releasing hormone 1 Homo sapiens 54-58 20601070-1 2010 In this study, we investigated the roles of prostaglandin (PG) F(2alpha) in the differentiation of mouse ST2 mesenchymal stem cells (MSC) into adipocytes and osteoblasts. Prostaglandins F 44-64 interleukin 1 receptor-like 1 Mus musculus 105-108 20826536-1 2010 This study was undertaken to investigate how prostaglandin F(2alpha) (PGF(2alpha)) increases PGF(2alpha) synthesis and PTGS2 expression in the corpus luteum of pseudopregnant rats. Prostaglandins F 45-60 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 119-124 20826536-1 2010 This study was undertaken to investigate how prostaglandin F(2alpha) (PGF(2alpha)) increases PGF(2alpha) synthesis and PTGS2 expression in the corpus luteum of pseudopregnant rats. Prostaglandins F 70-73 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 119-124 20826536-2 2010 We further investigated the molecular mechanism by which PGF(2alpha) stimulates PTGS2 expression. Prostaglandins F 57-60 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 80-85 20826536-5 2010 PGF(2alpha) significantly increased Ptgs2 mRNA expression at 2 h and luteal PGF(2alpha) concentrations at 24 h. PGF(2alpha) significantly decreased serum progesterone levels at all of the times studied. Prostaglandins F 0-3 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 36-41 20615530-5 2010 Among several enzymes involved in the prostaglandin synthesis pathway tested in the present study PGF(2alpha) synthase (PTGFS) and prostaglandin 9-ketoreductase (CBR1), which convert PGE(2) to PGF(2alpha), expression were significantly down-regulated in the oviducts on Day 1 after seminal plasma infusion into the uterine horns. Prostaglandins F 98-101 carbonyl reductase 1 Homo sapiens 162-166 20615530-5 2010 Among several enzymes involved in the prostaglandin synthesis pathway tested in the present study PGF(2alpha) synthase (PTGFS) and prostaglandin 9-ketoreductase (CBR1), which convert PGE(2) to PGF(2alpha), expression were significantly down-regulated in the oviducts on Day 1 after seminal plasma infusion into the uterine horns. Prostaglandins F 193-196 carbonyl reductase 1 Homo sapiens 131-160 20615530-5 2010 Among several enzymes involved in the prostaglandin synthesis pathway tested in the present study PGF(2alpha) synthase (PTGFS) and prostaglandin 9-ketoreductase (CBR1), which convert PGE(2) to PGF(2alpha), expression were significantly down-regulated in the oviducts on Day 1 after seminal plasma infusion into the uterine horns. Prostaglandins F 193-196 carbonyl reductase 1 Homo sapiens 162-166 20615530-9 2010 Altered PTGFS and CBR1 expression in consequence changed PGE(2) to PGF(2alpha) and PGFM to PGF(2alpha) ratios in the porcine oviduct. Prostaglandins F 67-70 carbonyl reductase 1 Homo sapiens 18-22 20615530-9 2010 Altered PTGFS and CBR1 expression in consequence changed PGE(2) to PGF(2alpha) and PGFM to PGF(2alpha) ratios in the porcine oviduct. Prostaglandins F 83-86 carbonyl reductase 1 Homo sapiens 18-22 20839316-6 2010 PGE(2) and PGF(2alpha) also decreased message for the anabolic factor, IGF-1. Prostaglandins F 11-14 insulin like growth factor 1 Homo sapiens 71-76 20839316-7 2010 PGE(2) decreased mRNA expression for the anti-catabolic factor TIMP-1 while PGF(2alpha) increased mRNAs for catabolic factors MMP-1 and MMP-3. Prostaglandins F 76-79 matrix metallopeptidase 1 Homo sapiens 126-131 20839316-7 2010 PGE(2) decreased mRNA expression for the anti-catabolic factor TIMP-1 while PGF(2alpha) increased mRNAs for catabolic factors MMP-1 and MMP-3. Prostaglandins F 76-79 matrix metallopeptidase 3 Homo sapiens 136-141 20826536-6 2010 Simultaneous administration of a selective PTGS2 inhibitor (NS-398, 10 mg/kg) completely abolished the increase in luteal PGF(2alpha) concentrations induced by PGF(2alpha). Prostaglandins F 122-125 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 43-48 20826536-6 2010 Simultaneous administration of a selective PTGS2 inhibitor (NS-398, 10 mg/kg) completely abolished the increase in luteal PGF(2alpha) concentrations induced by PGF(2alpha). Prostaglandins F 160-163 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 43-48 20826536-7 2010 PGF(2alpha) increased NFKB p65 protein expression in the nucleus of luteal cells 30 min after PGF(2alpha) injection, and electrophoretic mobility shift assay revealed that PGF(2alpha) increased binding activities of NFKB to the NFKB consensus sequence of the Ptgs2 gene promoter. Prostaglandins F 0-3 RELA proto-oncogene, NF-kB subunit Rattus norvegicus 22-26 20826536-7 2010 PGF(2alpha) increased NFKB p65 protein expression in the nucleus of luteal cells 30 min after PGF(2alpha) injection, and electrophoretic mobility shift assay revealed that PGF(2alpha) increased binding activities of NFKB to the NFKB consensus sequence of the Ptgs2 gene promoter. Prostaglandins F 0-3 synaptotagmin 1 Rattus norvegicus 27-30 20826536-7 2010 PGF(2alpha) increased NFKB p65 protein expression in the nucleus of luteal cells 30 min after PGF(2alpha) injection, and electrophoretic mobility shift assay revealed that PGF(2alpha) increased binding activities of NFKB to the NFKB consensus sequence of the Ptgs2 gene promoter. Prostaglandins F 0-3 RELA proto-oncogene, NF-kB subunit Rattus norvegicus 216-220 20826536-7 2010 PGF(2alpha) increased NFKB p65 protein expression in the nucleus of luteal cells 30 min after PGF(2alpha) injection, and electrophoretic mobility shift assay revealed that PGF(2alpha) increased binding activities of NFKB to the NFKB consensus sequence of the Ptgs2 gene promoter. Prostaglandins F 0-3 RELA proto-oncogene, NF-kB subunit Rattus norvegicus 216-220 20826536-7 2010 PGF(2alpha) increased NFKB p65 protein expression in the nucleus of luteal cells 30 min after PGF(2alpha) injection, and electrophoretic mobility shift assay revealed that PGF(2alpha) increased binding activities of NFKB to the NFKB consensus sequence of the Ptgs2 gene promoter. Prostaglandins F 0-3 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 259-264 20826536-8 2010 Simultaneous administration of both superoxide dismutase and catalase to scavenge reactive oxygen species (ROS) inhibited the increases of nuclear NFKB p65 protein expression, lipid peroxide levels, and Ptgs2 mRNA expression induced by PGF(2alpha). Prostaglandins F 236-239 catalase Rattus norvegicus 61-69 20826536-9 2010 In conclusion, PGF(2alpha) stimulates Ptgs2 mRNA expression and PGF(2alpha) synthesis through NFKB activation via ROS in the corpus luteum of pseudopregnant rats. Prostaglandins F 15-18 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 38-43 20826536-9 2010 In conclusion, PGF(2alpha) stimulates Ptgs2 mRNA expression and PGF(2alpha) synthesis through NFKB activation via ROS in the corpus luteum of pseudopregnant rats. Prostaglandins F 15-18 RELA proto-oncogene, NF-kB subunit Rattus norvegicus 94-98 20431270-5 2010 When the cultured luteal cells obtained from the mid-luteal stage CL (days 8-11) were exposed to CRH (50-5000 ng/ml), P secretion by the cells was significantly reduced at the highest dose (P<0.05), whereas CRH had no effect on E and PGF(2alpha) secretion by the cells. Prostaglandins F 237-240 corticotropin releasing hormone Sus scrofa 97-100 20601070-4 2010 The PGF(2alpha) production pattern during adipogenesis well resembled the expression profiles of aldo-keto reductase (AKR) 1B3, which acted as the PGF(2alpha) synthase, and cyclooxygenase-2 genes; but the pattern showed a slight delay compared with these profiles. Prostaglandins F 4-7 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 118-126 20601070-5 2010 The siRNA for AKR1B3, but not that for AKR1B8 or 1B10, decreased PGF(2alpha) production and enhanced the expression of adipogenic genes, but did not affect the mRNA levels of osteoblastogenic genes, during the adipogenesis of ST2 MSC. Prostaglandins F 65-68 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 14-20 20616214-1 2010 Oxytocin (OXT) and tumor necrosis factor alpha (TNF) have been implicated in the control of luteolysis by stimulating endometrial secretion of luteolytic prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 154-169 oxytocin/neurophysin I prepropeptide Homo sapiens 10-13 20616214-1 2010 Oxytocin (OXT) and tumor necrosis factor alpha (TNF) have been implicated in the control of luteolysis by stimulating endometrial secretion of luteolytic prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 154-169 tumor necrosis factor Homo sapiens 19-46 20616214-1 2010 Oxytocin (OXT) and tumor necrosis factor alpha (TNF) have been implicated in the control of luteolysis by stimulating endometrial secretion of luteolytic prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 154-169 tumor necrosis factor Homo sapiens 48-51 20616214-1 2010 Oxytocin (OXT) and tumor necrosis factor alpha (TNF) have been implicated in the control of luteolysis by stimulating endometrial secretion of luteolytic prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 179-182 oxytocin/neurophysin I prepropeptide Homo sapiens 10-13 20616214-1 2010 Oxytocin (OXT) and tumor necrosis factor alpha (TNF) have been implicated in the control of luteolysis by stimulating endometrial secretion of luteolytic prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 179-182 tumor necrosis factor Homo sapiens 19-46 20616214-1 2010 Oxytocin (OXT) and tumor necrosis factor alpha (TNF) have been implicated in the control of luteolysis by stimulating endometrial secretion of luteolytic prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 179-182 tumor necrosis factor Homo sapiens 48-51 20427144-8 2010 These findings suggest that PGF(2alpha) regulates luteolysis by ESR1 mRNA down-regulation and modulation of pro- and anti-apoptotic pathways in CL that have acquired a luteolytic capacity. Prostaglandins F 28-31 estrogen receptor Oryctolagus cuniculus 64-68 20484870-7 2010 Administration of PGF(2alpha) up-regulated the mRNA expressions of angiogenic-related factors such as vascular endothelial growth factors, vasohibin, fibroblast growth factor 2 and insulin-like growth factor-II in the early CL, whereas PGF(2alpha) down-regulated these mRNA expressions in the mid CL. Prostaglandins F 18-21 fibroblast growth factor 2 Bos taurus 150-210 20484870-8 2010 In the vasoactive factors, PGF(2alpha) stimulated the mRNA expressions of endothelin-1, angiotensin converting enzyme, endothelial nitric oxide synthase (NOS) and inducible NOS in the periphery area of the mid CL, but not in the early CL. Prostaglandins F 27-30 endothelin 1 Bos taurus 74-86 20484870-8 2010 In the vasoactive factors, PGF(2alpha) stimulated the mRNA expressions of endothelin-1, angiotensin converting enzyme, endothelial nitric oxide synthase (NOS) and inducible NOS in the periphery area of the mid CL, but not in the early CL. Prostaglandins F 27-30 nitric oxide synthase 3 Bos taurus 119-152 20484870-9 2010 However, PGF(2alpha) drastically down-regulated PGF(2alpha) receptor mRNA expression in both regions of the early and mid CL. Prostaglandins F 9-12 prostaglandin F receptor Bos taurus 48-68 20448048-3 2010 Unusual for OAT members, OAT-PG showed narrow substrate selectivity and high affinity for a specific subset of PGs, including PGE(2), PGF(2alpha), and PGD(2). Prostaglandins F 134-137 solute carrier family 22 (organic cation transporter), member 22 Mus musculus 25-31 20334988-7 2010 The ovarian steroids stimulated both PGF(2alpha) and PGE(2) in the epithelial cells of the feline endometrium via an E(2) receptor (ESR1)- and P(4) receptor (PGR)-dependent genomic-pathway. Prostaglandins F 37-40 estrogen receptor 1 Homo sapiens 132-136 20601070-7 2010 These results indicate that AKR1B3-mediated PGF(2alpha) suppressed the early phase of adipogenesis through FP receptors, but did not affect osteoblastogenesis in ST2 MSC. Prostaglandins F 44-47 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 28-34 20392830-10 2010 Hence, the inhibition by PGF(2alpha) and PGI(2) of the autoregulation of GnRH receptor expression is most likely mediated via inhibition of GnRH-stimulated phosphoinositide turnover and not by inhibition of Ca(2+) elevation and MAPK activation. Prostaglandins F 25-28 gonadotropin releasing hormone receptor Mus musculus 73-86 20542562-1 2010 We investigated the role of inositol 1,4,5-trisphosphate (IP(3))-receptor isoforms in the prostaglandin F(2alpha) (PGF(2alpha))-induced calcium oscillations and pacemaking activity of normal rat kidney (NRK) fibroblasts. Prostaglandins F 90-105 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 58-73 20542562-1 2010 We investigated the role of inositol 1,4,5-trisphosphate (IP(3))-receptor isoforms in the prostaglandin F(2alpha) (PGF(2alpha))-induced calcium oscillations and pacemaking activity of normal rat kidney (NRK) fibroblasts. Prostaglandins F 115-118 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 58-73 20542562-6 2010 Knockdown of the IP(3)R1 gene significantly decreased the frequency of the PGF(2alpha)-induced calcium oscillations in both Q- and DA-cells. Prostaglandins F 75-78 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 17-24 20542562-9 2010 Our findings indicate that the reduction in the frequency of PGF(2alpha)-induced calcium oscillations in DA-cells compared with Q-cells results from the reduced expression ratio of IP(3)R1 versus IP(3)R3 receptors in DA-cells. Prostaglandins F 61-64 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 181-188 20542562-9 2010 Our findings indicate that the reduction in the frequency of PGF(2alpha)-induced calcium oscillations in DA-cells compared with Q-cells results from the reduced expression ratio of IP(3)R1 versus IP(3)R3 receptors in DA-cells. Prostaglandins F 61-64 inositol 1,4,5-trisphosphate receptor, type 3 Rattus norvegicus 196-203 20392830-10 2010 Hence, the inhibition by PGF(2alpha) and PGI(2) of the autoregulation of GnRH receptor expression is most likely mediated via inhibition of GnRH-stimulated phosphoinositide turnover and not by inhibition of Ca(2+) elevation and MAPK activation. Prostaglandins F 25-28 mitogen-activated protein kinase 1 Mus musculus 228-232 20536573-0 2010 Prostaglandin F(2alpha) stimulates MEK-ERK signalling but decreases the expression of alkaline phosphatase in dental pulp cells. Prostaglandins F 0-15 mitogen-activated protein kinase kinase 7 Homo sapiens 35-38 20536573-0 2010 Prostaglandin F(2alpha) stimulates MEK-ERK signalling but decreases the expression of alkaline phosphatase in dental pulp cells. Prostaglandins F 0-15 mitogen-activated protein kinase 1 Homo sapiens 39-42 20536573-0 2010 Prostaglandin F(2alpha) stimulates MEK-ERK signalling but decreases the expression of alkaline phosphatase in dental pulp cells. Prostaglandins F 0-15 alkaline phosphatase, placental Homo sapiens 86-106 20536573-1 2010 AIM: To study prostaglandin F(2alpha) (PGF(2alpha)) receptor expression and downstream signalling in cultured human dental pulp cells and the effect of PGF(2alpha) on the alkaline phosphatase (ALP) activity of dental pulp cells. Prostaglandins F 14-29 prostaglandin F receptor Homo sapiens 39-60 20536573-5 2010 The expression of ALP in pulp cells after exposure to PGF(2alpha) was evaluated by ALP staining and PCR. Prostaglandins F 54-57 alkaline phosphatase, placental Homo sapiens 18-21 20536573-5 2010 The expression of ALP in pulp cells after exposure to PGF(2alpha) was evaluated by ALP staining and PCR. Prostaglandins F 54-57 alkaline phosphatase, placental Homo sapiens 83-86 20536573-8 2010 PGF(2alpha) induced both ERK and CREB/ATF-1 phosphorylation in pulp cells. Prostaglandins F 0-3 mitogen-activated protein kinase 1 Homo sapiens 25-28 20536573-8 2010 PGF(2alpha) induced both ERK and CREB/ATF-1 phosphorylation in pulp cells. Prostaglandins F 0-3 cAMP responsive element binding protein 1 Homo sapiens 33-37 20536573-8 2010 PGF(2alpha) induced both ERK and CREB/ATF-1 phosphorylation in pulp cells. Prostaglandins F 0-3 activating transcription factor 1 Homo sapiens 38-43 20536573-9 2010 Exposure to PGF(2alpha) (>1 micromol L(-1)) further decreased the ALP activity and mRNA expression. Prostaglandins F 12-15 alkaline phosphatase, placental Homo sapiens 69-72 20536573-11 2010 CONCLUSION: PGF(2alpha) may potentially activate FP receptors leading to ERK/CREB-ATF-1 activation during its production in inflamed dental pulp. Prostaglandins F 12-15 mitogen-activated protein kinase 1 Homo sapiens 73-76 20536573-11 2010 CONCLUSION: PGF(2alpha) may potentially activate FP receptors leading to ERK/CREB-ATF-1 activation during its production in inflamed dental pulp. Prostaglandins F 12-15 cAMP responsive element binding protein 1 Homo sapiens 77-81 20536573-11 2010 CONCLUSION: PGF(2alpha) may potentially activate FP receptors leading to ERK/CREB-ATF-1 activation during its production in inflamed dental pulp. Prostaglandins F 12-15 activating transcription factor 1 Homo sapiens 82-87 20536573-12 2010 PGF(2alpha) attenuated the ALP activity of pulp cells possibly via pathways not solely by MEK/ERK activation. Prostaglandins F 0-3 alkaline phosphatase, placental Homo sapiens 27-30 20067770-7 2010 In contrast, as expected, the selective COX-2 inhibitor, SC-236, inhibited PGE(2), PGF(1alpha) and PGF(2alpha) synthesis. Prostaglandins F 83-86 prostaglandin-endoperoxide synthase 2 Homo sapiens 40-45 20067770-7 2010 In contrast, as expected, the selective COX-2 inhibitor, SC-236, inhibited PGE(2), PGF(1alpha) and PGF(2alpha) synthesis. Prostaglandins F 99-102 prostaglandin-endoperoxide synthase 2 Homo sapiens 40-45 20032213-6 2010 IL1A also stimulated luteolytic PGF(2alpha) output in the late luteal phase. Prostaglandins F 32-35 interleukin 1 alpha Bos taurus 0-4 19965584-8 2010 Decreased IL-6 and IL-1(beta) levels correlated with decreased PGF(2alpha) levels. Prostaglandins F 63-66 interleukin 6 Homo sapiens 10-14 19965584-8 2010 Decreased IL-6 and IL-1(beta) levels correlated with decreased PGF(2alpha) levels. Prostaglandins F 63-66 interleukin 1 alpha Homo sapiens 19-29 20346915-2 2010 The prostaglandin carrier PGT mediates the transport of several prostanoids, such as PGE(2), and PGF(2alpha). Prostaglandins F 97-100 solute carrier organic anion transporter family member 2A1 Canis lupus familiaris 26-29 20147610-11 2010 The COX-2 inhibitor parecoxib lowered IM PGE(2,) TxB(2), 6-keto-PGF(1alpha), and PGF(2alpha) below vehicle-treated BUO and sham rats at 6, 12 and, 24 h BUO. Prostaglandins F 64-67 cytochrome c oxidase II, mitochondrial Rattus norvegicus 4-9 20147610-12 2010 The COX-1 inhibitor SC-560 lowered PGE(2), PGF(2alpha), and PGD(2) in IM compared with untreated 12 h BUO, but levels remained significantly above sham. Prostaglandins F 43-46 cytochrome c oxidase I, mitochondrial Rattus norvegicus 4-9 20147610-14 2010 In conclusion, COX-2 activity contributes to the transient increase in prostacyclin metabolite 6-keto-PGF(1alpha) and TxB(2) concentration in the kidney IM, and COX-2 is the predominant isoform that is responsible for accumulation of PGE(2) and PGF(2alpha) with minor, but significant, contributions from COX-1. Prostaglandins F 102-105 cytochrome c oxidase II, mitochondrial Rattus norvegicus 15-20 20093363-1 2010 Prostaglandin (PG) F(2alpha) suppresses adipocyte differentiation by inhibiting the function of peroxisome proliferator-activated receptor gamma. Prostaglandins F 0-20 peroxisome proliferator activated receptor gamma Mus musculus 96-144 20093363-9 2010 The small interfering RNA for Akr1b3, but not for Akr1b8 or 1b10, suppressed PGF(2alpha) production and enhanced the expression of adipogenic genes such as peroxisome proliferator-activated receptor gamma, fatty acid-binding protein 4 (aP2), and stearoyl-CoA desaturase. Prostaglandins F 77-80 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 30-36 20093363-11 2010 These results indicate that AKR1B3 acts as the PGFS in adipocytes and that AKR1B3-produced PGF(2alpha) suppressed adipocyte differentiation by acting through FP receptors. Prostaglandins F 47-50 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 28-34 20047585-11 2010 Production of prostaglandin F(2alpha) by peritoneal macrophages was increased after leptin stimulation in women with endometriosis. Prostaglandins F 14-29 leptin Homo sapiens 84-90 20080869-4 2010 OT receptor was coupled to the classical G alpha(q) pathway as evidenced by calcium release and activation of phospholipase C. Similarly, OT-induced PGF(2 alpha) production was mediated through the canonical ERK1/2 pathway. Prostaglandins F 149-152 mitogen-activated protein kinase 3 Bos taurus 208-214 20080869-6 2010 The EGFR inhibitor AG1478 (10 microm) nearly abolished basal and OT-induced PGF(2 alpha) production and down-regulated COX2 expression and ERK1/2 phosphorylation. Prostaglandins F 76-79 epidermal growth factor receptor Bos taurus 4-8 20080869-7 2010 Because the transactivated EGFR can serve as a ligand for the signaling proteins with Src homology 2 (SH2) domain, we hypothesized a role for c-Src and PI3K in OT-induced PGF(2 alpha) production. Prostaglandins F 171-174 epidermal growth factor receptor Bos taurus 27-31 20080869-10 2010 Because LY294002 did not affect ERK1/2 phosphorylation, but inhibited PGF(2 alpha) production and down-regulated COX2 expression, it is likely that the Akt pathway is also involved in PGF(2 alpha) production. Prostaglandins F 184-187 AKT serine/threonine kinase 1 Bos taurus 152-155 20080869-11 2010 Thus, EGFR may simultaneously activate c-Src and PI3K to amplify the OT signaling to increase the output of PGF(2 alpha) in bEEL cells. Prostaglandins F 108-111 epidermal growth factor receptor Bos taurus 6-10 20032213-9 2010 Only the highest dose of IL1A caused a temporal increase in PGF(2alpha) secretion, while it had no effect on P(4) secretion or CL lifespan. Prostaglandins F 60-63 interleukin 1 alpha Bos taurus 25-29 20032213-11 2010 Although IL1A may stimulate in vitro luteolytic PGF(2alpha) secretion during the estrous cycle, it only acts as a luteotrophic factor in vivo. Prostaglandins F 48-51 interleukin 1 alpha Bos taurus 9-13 19812299-5 2010 In a second experiment, the response to oxytocin was increased (P < 0.05) by 3 h (but not 1 h) following progesterone removal, with a further increase by 16 h. The ability of 1 muM prostaglandin F(2 alpha) (PGF(2 alpha)) to increase intracellular concentrations of calcium was also decreased (P < 0.05) by progesterone treatment. Prostaglandins F 184-199 latexin Homo sapiens 180-183 19819266-3 2009 Furthermore we found that PGF(2alpha)-F-prostanoid (FP) receptor regulates the expression of the CXCR2 ligand CXCL1, to promote neutrophil chemotaxis in endometrial adenocarcinomas. Prostaglandins F 26-29 chemokine (C-X-C motif) receptor 2 Mus musculus 97-102 20080921-9 2010 Levels of 11ss-PGF(2alpha) and bone ALP were positively correlated, suggesting that PGD(2) may be implicated in fracture repair. Prostaglandins F 15-18 prostaglandin D2 synthase Homo sapiens 84-90 20092633-3 2010 We have shown previously that PGF(2alpha)-FP receptor signalling in endometrial adenocarcinoma cells can upregulate several angiogenic factors including fibroblast growth factor-2 (FGF2). Prostaglandins F 30-33 fibroblast growth factor 2 Homo sapiens 153-179 20092633-3 2010 We have shown previously that PGF(2alpha)-FP receptor signalling in endometrial adenocarcinoma cells can upregulate several angiogenic factors including fibroblast growth factor-2 (FGF2). Prostaglandins F 30-33 fibroblast growth factor 2 Homo sapiens 181-185 19788885-1 2010 F(2)-isoprostanes are stereo- and regioisomers of prostaglandin F(2alpha) (PGF(2alpha)) and are used as biomarkers for lipid peroxidation. Prostaglandins F 50-65 placental growth factor Homo sapiens 75-78 20008143-3 2010 This study investigated the expression of IL-11 and role of prostaglandin F(2alpha)-F-prostanoid receptor (FP receptor) signaling in the modulation of IL-11 expression in endometrial adenocarcinoma cells. Prostaglandins F 60-75 interleukin 11 Homo sapiens 151-156 20008143-8 2010 Prostaglandin F(2alpha)-FP receptor signaling significantly elevated the expression of IL-11 mRNA and protein in a Gq-protein kinase C-calcium-calcineurin-nuclear factor of activated T cells-dependent manner in FPS cells. Prostaglandins F 0-15 interleukin 11 Homo sapiens 87-92 19782748-0 2010 EP2 receptor mediated cAMP release is augmented by PGF 2 alpha activation of the FP receptor via the calcium-calmodulin pathway. Prostaglandins F 51-54 prostaglandin E receptor 2 Homo sapiens 0-3 19782748-4 2010 PGF-mediated potentiation of cAMP release was abolished by antagonism of the FP receptor, inhibition of phospholipase C (PLC) and inositol phosphate receptor (IP3R) whereas inhibition of protein kinase C (PKC) had no effect. Prostaglandins F 0-3 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 159-163 19782748-5 2010 Moreover, inhibition of calcium effectors using calmodulin antagonist (W7) or Ca(2+)/calmodulin-dependent kinase II (CaMK-II) inhibitor (KN-93) abolished PGF potentiation of Butaprost-mediated cAMP release. Prostaglandins F 154-157 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 78-115 19782748-5 2010 Moreover, inhibition of calcium effectors using calmodulin antagonist (W7) or Ca(2+)/calmodulin-dependent kinase II (CaMK-II) inhibitor (KN-93) abolished PGF potentiation of Butaprost-mediated cAMP release. Prostaglandins F 154-157 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 117-124 19819266-3 2009 Furthermore we found that PGF(2alpha)-F-prostanoid (FP) receptor regulates the expression of the CXCR2 ligand CXCL1, to promote neutrophil chemotaxis in endometrial adenocarcinomas. Prostaglandins F 26-29 chemokine (C-X-C motif) ligand 1 Mus musculus 110-115 19819266-4 2009 In the present study we identified another CXCR2 ligand, CXCL8 as a target for PGF(2alpha)-FP receptor signalling which enhances epithelial cell proliferation in endometrial adenocarcinoma cells in vitro and in nude mice in vivo. Prostaglandins F 79-82 chemokine (C-X-C motif) receptor 2 Mus musculus 43-48 19819266-6 2009 Promoter analysis revealed that CXCL8 transcriptional activation by PGF(2alpha) signaling is mediated by cooperative interactions between the AP1 and NFAT binding sites. Prostaglandins F 68-71 jun proto-oncogene Mus musculus 142-145 19819266-7 2009 Furthermore, PGF(2alpha) via the FP receptor induced the expression of the regulator of calcineurin 1 isoform 4 (RCAN1-4) via the calcineurin/NFAT pathway in a reciprocal manner to CXCL8. Prostaglandins F 13-16 regulator of calcineurin 1 Mus musculus 113-120 19081211-12 2009 Thus, extracellular Ca entry and MLCK phosphorylation are essential for uterine force production occurring spontaneously or by PGF(2alpha) stimulation. Prostaglandins F 127-130 myosin light chain kinase Gallus gallus 33-37 19645054-6 2009 The activity of caspase-2, -3, and -8 was significantly greater by 4 hr after PGF-2alpha, but not caspase-9 activity. Prostaglandins F 78-81 caspase 2 Rattus norvegicus 16-37 19645054-12 2009 These results suggest that S1P blocks the luteolytic effect of the PGF-2alpha by decreasing caspase-2, -3, and -8 activities and increasing AKT phosphorylation and TNF-alpha expression. Prostaglandins F 67-70 caspase 2 Rattus norvegicus 92-113 19645054-12 2009 These results suggest that S1P blocks the luteolytic effect of the PGF-2alpha by decreasing caspase-2, -3, and -8 activities and increasing AKT phosphorylation and TNF-alpha expression. Prostaglandins F 67-70 AKT serine/threonine kinase 1 Rattus norvegicus 140-143 19645054-12 2009 These results suggest that S1P blocks the luteolytic effect of the PGF-2alpha by decreasing caspase-2, -3, and -8 activities and increasing AKT phosphorylation and TNF-alpha expression. Prostaglandins F 67-70 tumor necrosis factor Rattus norvegicus 164-173 19765667-7 2009 The objective of this experiment was to determine the effects of endocannabinoid type 1 and 2 receptor agonists and receptor antagonists or a fatty acid amide hydrolase (FAAH; catabolizes endocannabinoids) inhibitor, PGE(1), or PGF(2)alpha on bovine luteal secretion of progesterone, PGE, and PGF(2)alphain vitro. Prostaglandins F 228-231 fatty-acid amide hydrolase 1 Bos taurus 170-174 19765667-7 2009 The objective of this experiment was to determine the effects of endocannabinoid type 1 and 2 receptor agonists and receptor antagonists or a fatty acid amide hydrolase (FAAH; catabolizes endocannabinoids) inhibitor, PGE(1), or PGF(2)alpha on bovine luteal secretion of progesterone, PGE, and PGF(2)alphain vitro. Prostaglandins F 293-296 fatty-acid amide hydrolase 1 Bos taurus 170-174 19765667-10 2009 Both PGE and PGF(2)alpha were decreased (P< or =0.05) by CB(1) or CB(2) receptor agonists or a FAAH inhibitor when compared to vehicle controls. Prostaglandins F 13-16 fatty-acid amide hydrolase 1 Bos taurus 98-102 20501437-11 2009 A COX-1 inhibitor decreased and a COX-2 inhibitor increased PGF(2alpha) levels; GTPgammaS increased and GDPbetaS decreased the levels of PGF(2alpha). Prostaglandins F 60-63 cytochrome c oxidase subunit II Cavia porcellus 34-39 20501437-14 2009 We concluded that P4 decreases basal MI by reducing PGF(2alpha) levels caused by downregulation of Galpha(q/11) and that PGF(2alpha)-induced contraction was blocked by downregulating Galpha(i3). Prostaglandins F 121-124 brain protein I3 Cavia porcellus 183-192 19723588-1 2009 Endothelin-1 (ET-1) has been reported to mediate prostaglandin (PG) F(2)alpha (PGF(2)alpha)-induced luteolysis. Prostaglandins F 49-69 endothelin 1 Bos taurus 0-12 19723588-1 2009 Endothelin-1 (ET-1) has been reported to mediate prostaglandin (PG) F(2)alpha (PGF(2)alpha)-induced luteolysis. Prostaglandins F 49-69 endothelin 1 Bos taurus 14-18 19723588-1 2009 Endothelin-1 (ET-1) has been reported to mediate prostaglandin (PG) F(2)alpha (PGF(2)alpha)-induced luteolysis. Prostaglandins F 79-82 endothelin 1 Bos taurus 0-12 19723588-1 2009 Endothelin-1 (ET-1) has been reported to mediate prostaglandin (PG) F(2)alpha (PGF(2)alpha)-induced luteolysis. Prostaglandins F 79-82 endothelin 1 Bos taurus 14-18 19723588-9 2009 Treatment with ET-1-IP or ET-1-IU increased (P< or =0.05) the PGE:PGF(2)alpha ratio when compared to the Vehicle-IP or Vehicle-IU treatment groups, which did not differ (P> or =0.05) between each other. Prostaglandins F 69-72 endothelin 1 Bos taurus 15-19 19723588-9 2009 Treatment with ET-1-IP or ET-1-IU increased (P< or =0.05) the PGE:PGF(2)alpha ratio when compared to the Vehicle-IP or Vehicle-IU treatment groups, which did not differ (P> or =0.05) between each other. Prostaglandins F 69-72 endothelin 1 Bos taurus 26-30 19723588-10 2009 In summary, ET-1 prevented the decrease in luteal weights and the decline in progesterone, but increased the PGE:PGF(2)alpha ratio when compared to controls. Prostaglandins F 113-116 endothelin 1 Bos taurus 12-16 19843949-3 2009 We report that in vitro, murine B cells constitutively expressed COX-1 and up-regulated expression of both COX-1 and COX-2 as well as their products PGE(2), PGF(2alpha), and thromboxane B(2) and their receptors following stimulation with B. burgdorferi or anti-CD40. Prostaglandins F 157-160 cytochrome c oxidase I, mitochondrial Mus musculus 65-70 19809495-8 2009 In steroidogenic cells, PGF(2alpha) secretion was stimulated by adrenocorticotropic hormone (ACTH) and correlated to ACTH-responsiveness of both COX2 and AKR1B7/B1. Prostaglandins F 24-27 aldo-keto reductase family 1, member B7 Mus musculus 154-160 19809495-9 2009 The pivotal role of AKR1B7 in ACTH-induced PGF(2alpha) release and functional coupling with COX2 was demonstrated using over- and down-expression in cell lines. Prostaglandins F 43-46 aldo-keto reductase family 1, member B7 Mus musculus 20-26 19081211-13 2009 Our data supports the conclusion that the pathway dependent on extracellular Ca entry and MLCK phosphorylation predominates during PGF(2alpha) stimulation but suggests some involvement of an alternative force-producing pathway, presumably Ca-sensitization. Prostaglandins F 131-134 myosin light chain kinase Gallus gallus 90-94 19584306-7 2009 PGE(2) was the most selective in activating Galpha(s), whereas PGF(2alpha) and PGE(1) alcohol were the most biased for activating Galpha(i1) and beta-arrestin, respectively. Prostaglandins F 63-66 protein phosphatase 1 regulatory inhibitor subunit 1A Homo sapiens 130-139 19464306-6 2009 Moreover, contractions induced by oxytocin or different prostaglandins (PGF(2alpha), PGE(2), and a prostaglandin analogue, misoprostol) were inhibited rather than increased by RU 486. Prostaglandins F 72-75 oxytocin/neurophysin I prepropeptide Homo sapiens 34-42 19616295-6 2009 Secretion of P(4), T, E(2), IGF-I, and prostaglandin F (PGF) was assessed in culture medium by RIA. Prostaglandins F 39-54 placenta growth factor Oryctolagus cuniculus 56-59 19809495-7 2009 In chromaffin cells, PGF(2alpha) secretion appeared constitutive and correlated to continuous expression of COX1 and AKR1B3. Prostaglandins F 21-24 cytochrome c oxidase I, mitochondrial Mus musculus 108-112 19809495-7 2009 In chromaffin cells, PGF(2alpha) secretion appeared constitutive and correlated to continuous expression of COX1 and AKR1B3. Prostaglandins F 21-24 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 117-123 19809495-8 2009 In steroidogenic cells, PGF(2alpha) secretion was stimulated by adrenocorticotropic hormone (ACTH) and correlated to ACTH-responsiveness of both COX2 and AKR1B7/B1. Prostaglandins F 24-27 proopiomelanocortin Homo sapiens 64-91 19809495-8 2009 In steroidogenic cells, PGF(2alpha) secretion was stimulated by adrenocorticotropic hormone (ACTH) and correlated to ACTH-responsiveness of both COX2 and AKR1B7/B1. Prostaglandins F 24-27 mitochondrially encoded cytochrome c oxidase II Homo sapiens 145-149 19758455-0 2009 Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha. Prostaglandins F 114-129 estrogen receptor 1 Homo sapiens 174-181 19596830-3 2009 TNFalpha stimulated PGF(2alpha) secretion on Day 0 (onset of estrus = Day 0) and Days 2-3, in both the ampulla and isthmus, but on Days 18-20 only in ampulla. Prostaglandins F 20-23 tumor necrosis factor Bos taurus 0-8 19596830-12 2009 When taken together, TNFalpha seems to play some role as a modulator of PGF(2alpha) and PGE(2) production and for transferring the embryo from the oviduct to the uterus by stimulating NO production in the bovine oviduct. Prostaglandins F 72-75 tumor necrosis factor Bos taurus 21-29 19502454-2 2009 At the end of pregnancy, prostaglandin F2alpha (PGF(2alpha)) induces luteal regression through many mechanisms, including downregulation of PRLR signaling. Prostaglandins F 48-51 prolactin receptor Rattus norvegicus 140-144 19502454-3 2009 We have previously shown that a PGF(2alpha) analog upregulates suppressors of cytokine signaling (SOCS) proteins in the CL of day 19 pregnant rats leading to reduced STAT5 signaling. Prostaglandins F 32-35 cytokine inducible SH2-containing protein Rattus norvegicus 98-102 19502454-3 2009 We have previously shown that a PGF(2alpha) analog upregulates suppressors of cytokine signaling (SOCS) proteins in the CL of day 19 pregnant rats leading to reduced STAT5 signaling. Prostaglandins F 32-35 signal transducer and activator of transcription 5A Rattus norvegicus 166-171 19502454-10 2009 Therefore, these results are consistent with the hypothesis that increased SOCS expression in the rat ovary during late pregnancy reduces STAT5 signaling, which may be important in PGF(2alpha)-induced luteolysis. Prostaglandins F 181-184 cytokine inducible SH2-containing protein Rattus norvegicus 75-79 19502454-10 2009 Therefore, these results are consistent with the hypothesis that increased SOCS expression in the rat ovary during late pregnancy reduces STAT5 signaling, which may be important in PGF(2alpha)-induced luteolysis. Prostaglandins F 181-184 signal transducer and activator of transcription 5A Rattus norvegicus 138-143 19528263-7 2009 Overexpression of STAT1 reversed the effect of ghrelin on STAT1, PCNA, PGF, OXT (from stimulatory to inhibitory), BCL2, P(4) (from inhibitory to stimulatory), prevented ghrelin effect on caspase-3 and BAX, but did not affect ghrelin"s effect on MAPK/ERK1,2 expression. Prostaglandins F 71-74 signal transducer and activator of transcription 1 Homo sapiens 18-23 19528263-9 2009 Furthermore, they demonstrated the involvement of the transcription factor STAT1 in controlling these functions, the promotion of some markers of apoptosis (BAX), inhibition of some markers of proliferation (MAPK/ERK1,2) and stimulation of PGF release. Prostaglandins F 240-243 signal transducer and activator of transcription 1 Homo sapiens 75-80 19579042-11 2009 Decreased Te biosynthesis may be attributed to (1) inhibition of StAR protein activity due to the stimulation of COX-2 and the overproduction of PGF(2alpha), (2) decreased stimulatory effect of ARA on StAR with a subsequent reduction in the availability of CHO for the androgenic pathway, and/or (3) indirect inhibition of steroidogenic enzymes by a lower transcriptional rate caused by elevated PGF(2alpha). Prostaglandins F 145-148 steroidogenic acute regulatory protein Rattus norvegicus 65-69 18930361-2 2009 In this study, we determined the effects of IL-1alpha and IL-1beta on production of the prostaglandins PGF(2alpha) and PGE(2) and on PA activity in cultured bovine endometrial epithelial and stromal cells. Prostaglandins F 103-106 interleukin 1 alpha Bos taurus 44-53 18930361-2 2009 In this study, we determined the effects of IL-1alpha and IL-1beta on production of the prostaglandins PGF(2alpha) and PGE(2) and on PA activity in cultured bovine endometrial epithelial and stromal cells. Prostaglandins F 103-106 interleukin 1 beta Bos taurus 58-66 18930361-6 2009 When cultured cells were exposed to IL-1alpha and IL-1beta at concentrations ranging from 0.006 to 3 nM for 24h, IL-1alpha and IL-1beta were found to dose-dependently stimulate PGE(2) and PGF(2alpha) production in stromal cells (P<0.05) but not in epithelial cells. Prostaglandins F 188-191 interleukin 1 alpha Bos taurus 36-45 18930361-6 2009 When cultured cells were exposed to IL-1alpha and IL-1beta at concentrations ranging from 0.006 to 3 nM for 24h, IL-1alpha and IL-1beta were found to dose-dependently stimulate PGE(2) and PGF(2alpha) production in stromal cells (P<0.05) but not in epithelial cells. Prostaglandins F 188-191 interleukin 1 beta Bos taurus 50-58 18930361-6 2009 When cultured cells were exposed to IL-1alpha and IL-1beta at concentrations ranging from 0.006 to 3 nM for 24h, IL-1alpha and IL-1beta were found to dose-dependently stimulate PGE(2) and PGF(2alpha) production in stromal cells (P<0.05) but not in epithelial cells. Prostaglandins F 188-191 interleukin 1 alpha Bos taurus 113-122 18930361-6 2009 When cultured cells were exposed to IL-1alpha and IL-1beta at concentrations ranging from 0.006 to 3 nM for 24h, IL-1alpha and IL-1beta were found to dose-dependently stimulate PGE(2) and PGF(2alpha) production in stromal cells (P<0.05) but not in epithelial cells. Prostaglandins F 188-191 interleukin 1 beta Bos taurus 127-135 18930361-8 2009 When cells were exposed to IL-1alpha and IL-1beta at concentrations ranging from 0.06 to 3 nM for 24h, the two IL-1s differed in their effects on both PGE(2) and PGF(2alpha) production in stromal cells and had significantly differed in their effects on PA activity in epithelial cells. Prostaglandins F 162-165 interleukin 1 alpha Bos taurus 27-36 18930361-8 2009 When cells were exposed to IL-1alpha and IL-1beta at concentrations ranging from 0.06 to 3 nM for 24h, the two IL-1s differed in their effects on both PGE(2) and PGF(2alpha) production in stromal cells and had significantly differed in their effects on PA activity in epithelial cells. Prostaglandins F 162-165 interleukin 1 beta Bos taurus 41-49 18849138-7 2009 Acetylsalicylic acid can inhibit PGF(2)alpha synthesis and PGF(2)alpha is a key stimulator of MMP-2 production. Prostaglandins F 59-62 matrix metallopeptidase 2 Mus musculus 94-99 19638525-3 2009 PGF was estimated 1 month after the last infusion by the beta-score, a previously validated index (range 0-8) based on insulin or oral treatment requirements, plasma C-peptide, blood glucose, and A1C. Prostaglandins F 0-3 insulin Homo sapiens 119-126 19579042-11 2009 Decreased Te biosynthesis may be attributed to (1) inhibition of StAR protein activity due to the stimulation of COX-2 and the overproduction of PGF(2alpha), (2) decreased stimulatory effect of ARA on StAR with a subsequent reduction in the availability of CHO for the androgenic pathway, and/or (3) indirect inhibition of steroidogenic enzymes by a lower transcriptional rate caused by elevated PGF(2alpha). Prostaglandins F 396-399 steroidogenic acute regulatory protein Rattus norvegicus 65-69 19184985-6 2009 Interestingly, hypoxia also increased the level of prostaglandin F(2alpha) (PGF(2alpha)), a product of dihydrodiol dehydrogenase (DDH). Prostaglandins F 51-66 dihydrodiol dehydrogenase Homo sapiens 103-128 19549892-1 2009 The prostaglandin F(2alpha) (PGF(2alpha)) receptor (FP) is elevated in endometrial adenocarcinoma. Prostaglandins F 4-19 prostaglandin F receptor Mus musculus 29-50 19549892-2 2009 This study found that PGF(2alpha) signaling via FP regulates expression of chemokine (C-X-C motif) ligand 1 (CXCL1) in endometrial adenocarcinoma cells. Prostaglandins F 22-25 chemokine (C-X-C motif) ligand 1 Mus musculus 75-107 19549892-2 2009 This study found that PGF(2alpha) signaling via FP regulates expression of chemokine (C-X-C motif) ligand 1 (CXCL1) in endometrial adenocarcinoma cells. Prostaglandins F 22-25 chemokine (C-X-C motif) ligand 1 Mus musculus 109-114 19549892-4 2009 Treatment of Ishikawa cells stably transfected with the FP receptor (FPS cells) with 100 nmol/L PGF(2alpha) increased CXCL1 promoter activity, mRNA, and protein expression, and these effects were abolished by cotreatment of cells with FP antagonist or chemical inhibitors of Gq, epidermal growth factor receptor, and extracellular signal-regulated kinase. Prostaglandins F 96-99 C-X-C motif chemokine ligand 1 Homo sapiens 118-123 19549892-4 2009 Treatment of Ishikawa cells stably transfected with the FP receptor (FPS cells) with 100 nmol/L PGF(2alpha) increased CXCL1 promoter activity, mRNA, and protein expression, and these effects were abolished by cotreatment of cells with FP antagonist or chemical inhibitors of Gq, epidermal growth factor receptor, and extracellular signal-regulated kinase. Prostaglandins F 96-99 epidermal growth factor receptor Homo sapiens 279-311 19549892-5 2009 Similarly, CXCL1 was elevated in response to 100 nmol/L PGF(2alpha) in endometrial adenocarcinoma explant tissue. Prostaglandins F 56-59 chemokine (C-X-C motif) ligand 1 Mus musculus 11-16 19549892-8 2009 Conditioned media from PGF(2alpha)-treated FPS cells stimulated neutrophil chemotaxis, which could be abolished by CXCL1 protein immunoneutralization of the conditioned media or antagonism of CXCR2. Prostaglandins F 23-26 chemokine (C-X-C motif) ligand 1 Mus musculus 115-120 19549892-8 2009 Conditioned media from PGF(2alpha)-treated FPS cells stimulated neutrophil chemotaxis, which could be abolished by CXCL1 protein immunoneutralization of the conditioned media or antagonism of CXCR2. Prostaglandins F 23-26 chemokine (C-X-C motif) receptor 2 Mus musculus 192-197 19423560-8 2009 In a multiple stepwise linear regression analysis, cIMT was related with PGF-2alpha (beta=0.641, P<0.001) and HOMA-IR (beta=0.307; P<0.001). Prostaglandins F 73-76 CIMT Homo sapiens 51-55 19184985-6 2009 Interestingly, hypoxia also increased the level of prostaglandin F(2alpha) (PGF(2alpha)), a product of dihydrodiol dehydrogenase (DDH). Prostaglandins F 51-66 dihydrodiol dehydrogenase Homo sapiens 130-133 19184985-6 2009 Interestingly, hypoxia also increased the level of prostaglandin F(2alpha) (PGF(2alpha)), a product of dihydrodiol dehydrogenase (DDH). Prostaglandins F 76-79 dihydrodiol dehydrogenase Homo sapiens 103-128 19184985-6 2009 Interestingly, hypoxia also increased the level of prostaglandin F(2alpha) (PGF(2alpha)), a product of dihydrodiol dehydrogenase (DDH). Prostaglandins F 76-79 dihydrodiol dehydrogenase Homo sapiens 130-133 19184985-7 2009 When expression of DDH was suppressed by siRNA, the levels of PGF(2alpha), HGF and IL-8 were reduced; however, their levels returned to normal after DDH was reintroduced. Prostaglandins F 62-65 dihydrodiol dehydrogenase Homo sapiens 19-22 19184985-8 2009 These data suggest that hypoxia induces biosynthesis of PGF(2alpha), which then activates HGF and IL-8 expression. Prostaglandins F 56-59 hepatocyte growth factor Homo sapiens 90-93 19184985-8 2009 These data suggest that hypoxia induces biosynthesis of PGF(2alpha), which then activates HGF and IL-8 expression. Prostaglandins F 56-59 C-X-C motif chemokine ligand 8 Homo sapiens 98-102 19184985-9 2009 The results provide a reasonable explanation of how PGF(2alpha), HGF and IL-8 exert their effects on cancer cell metastasis. Prostaglandins F 52-55 C-X-C motif chemokine ligand 8 Homo sapiens 73-77 19357132-1 2009 We have previously observed expression of prostaglandin-endoperoxide synthase 2 (PTGS2), the key enzyme in the biosynthesis of prostaglandins (PGs), in reproductively active Syrian hamster Leydig cells, and reported an inhibitory role of PGF(2alpha) on hamster testicular steroidogenesis. Prostaglandins F 238-241 prostaglandin G/H synthase 2 Mesocricetus auratus 81-86 19357132-7 2009 Because Bi and U0126, an inhibitor of the MAP kinase kinases 1 and 2 (MAP2K1/2), abolished testosterone actions on MAPK3/1 and PTGS2, our studies suggest that testosterone directly induces PTGS2/PGF(2alpha) in hamster Leydig cells via androgen receptors and a non-classical mechanism that involves MAPK3/1 activation. Prostaglandins F 195-198 prostaglandin G/H synthase 2 Mesocricetus auratus 189-194 19248765-0 2009 PGF(2alpha) stimulates FP prostanoid receptor mediated crosstalk between Ras/Raf signaling and Tcf transcriptional activation. Prostaglandins F 0-3 zinc fingers and homeoboxes 2 Homo sapiens 77-80 18564315-6 2009 One microgram TNF increased PGF(2alpha) and NO (p < 0.001) and decreased P4 (p < 0.05). Prostaglandins F 28-31 tumor necrosis factor Bos taurus 14-17 19289115-4 2009 The natural prostanoid FP-receptor agonist, PGF(2alpha), and its selective analogues, latanoprost and bimatoprost free acids are full agonists (produce more than 80% of the maximal contractile response to 5-HT) in human umbilical vein. Prostaglandins F 44-47 prostaglandin F receptor Homo sapiens 12-34 19289115-6 2009 The contractile effects of PGF(2alpha) and latanoprost free acid were blocked competitively by the prostanoid FP-receptor antagonist, AL-8810. Prostaglandins F 27-30 prostaglandin F receptor Homo sapiens 99-121 19164179-12 2009 PGF(2alpha) increased the expression of a guanine nucleotide-binding protein (G protein) beta polypeptide 1 (GNB1) in D-4 CL and calcium/calmodulin-dependent kinase kinase 2 beta (CAMKK2) in D-10 CL. Prostaglandins F 0-3 G protein subunit beta 1 Bos taurus 109-113 19164179-12 2009 PGF(2alpha) increased the expression of a guanine nucleotide-binding protein (G protein) beta polypeptide 1 (GNB1) in D-4 CL and calcium/calmodulin-dependent kinase kinase 2 beta (CAMKK2) in D-10 CL. Prostaglandins F 0-3 calcium/calmodulin dependent protein kinase kinase 2 Bos taurus 180-186 19164179-13 2009 Therefore, GNB1, CAMKK2, YWHAZ, and RGS2 are candidate genes that may have a significant role in acquisition of luteal sensitivity to PGF(2alpha). Prostaglandins F 134-137 G protein subunit beta 1 Bos taurus 11-15 19164179-13 2009 Therefore, GNB1, CAMKK2, YWHAZ, and RGS2 are candidate genes that may have a significant role in acquisition of luteal sensitivity to PGF(2alpha). Prostaglandins F 134-137 calcium/calmodulin dependent protein kinase kinase 2 Bos taurus 17-23 19164179-13 2009 Therefore, GNB1, CAMKK2, YWHAZ, and RGS2 are candidate genes that may have a significant role in acquisition of luteal sensitivity to PGF(2alpha). Prostaglandins F 134-137 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Bos taurus 25-30 19164179-13 2009 Therefore, GNB1, CAMKK2, YWHAZ, and RGS2 are candidate genes that may have a significant role in acquisition of luteal sensitivity to PGF(2alpha). Prostaglandins F 134-137 LOC616414 Bos taurus 36-40 19164179-15 2009 Furthermore, the two types of luteal steroidogenic cells known to be targets for PGF(2alpha) actions were demonstrated to be a cellular source for CAMKK2. Prostaglandins F 81-84 calcium/calmodulin dependent protein kinase kinase 2 Bos taurus 147-153 19248765-0 2009 PGF(2alpha) stimulates FP prostanoid receptor mediated crosstalk between Ras/Raf signaling and Tcf transcriptional activation. Prostaglandins F 0-3 hepatocyte nuclear factor 4 alpha Homo sapiens 95-98 19261428-6 2009 Secretion of P(4), T, E(2), IGF-I, and prostaglandin F (PGF) by granulosa cells cultured with and without LH or IGF-I (1, 10 or 100 ng/ml medium) was assessed by RIA. Prostaglandins F 39-54 placenta growth factor Oryctolagus cuniculus 56-59 19345795-0 2009 Prostaglandin F(2alpha)-induced interleukin-8 production in human dental pulp cells is associated with MEK/ERK signaling. Prostaglandins F 0-15 C-X-C motif chemokine ligand 8 Homo sapiens 32-45 19345795-0 2009 Prostaglandin F(2alpha)-induced interleukin-8 production in human dental pulp cells is associated with MEK/ERK signaling. Prostaglandins F 0-15 mitogen-activated protein kinase kinase 7 Homo sapiens 103-106 19345795-0 2009 Prostaglandin F(2alpha)-induced interleukin-8 production in human dental pulp cells is associated with MEK/ERK signaling. Prostaglandins F 0-15 mitogen-activated protein kinase 1 Homo sapiens 107-110 19345795-3 2009 We found that IL-1beta stimulated PGF(2alpha) production of human dental pulp cells. Prostaglandins F 34-37 interleukin 1 beta Homo sapiens 14-22 19345795-4 2009 IL-1beta and PGF(2alpha) (0.5-10 mumol/L) also induced IL-8 production and mRNA expression in pulp cells. Prostaglandins F 13-16 C-X-C motif chemokine ligand 8 Homo sapiens 55-59 19345795-5 2009 Aspirin inhibited IL-1beta-induced PGF(2alpha), but not IL-8 production. Prostaglandins F 35-38 interleukin 1 beta Homo sapiens 18-26 19345795-6 2009 PGF(2alpha)-induced IL-8 production and mRNA expression were inhibited by U0126 (an inhibitor of mitogen-activated protein kinase kinase [MEK1/2]) inhibitor), whereas SQ22536 (an adenylate cyclase inhibitor) enhanced this event. Prostaglandins F 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 20-24 19345795-6 2009 PGF(2alpha)-induced IL-8 production and mRNA expression were inhibited by U0126 (an inhibitor of mitogen-activated protein kinase kinase [MEK1/2]) inhibitor), whereas SQ22536 (an adenylate cyclase inhibitor) enhanced this event. Prostaglandins F 0-3 mitogen-activated protein kinase kinase 1 Homo sapiens 138-144 19345795-8 2009 PGF(2alpha)-induced IL-8 production is possibly via activation of MEK/extracellular signal-regulated kinase signaling, but not by activation of adenylate cyclase. Prostaglandins F 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 20-24 19345795-8 2009 PGF(2alpha)-induced IL-8 production is possibly via activation of MEK/extracellular signal-regulated kinase signaling, but not by activation of adenylate cyclase. Prostaglandins F 0-3 mitogen-activated protein kinase kinase 7 Homo sapiens 66-69 19345795-9 2009 IL-1beta and PGF(2alpha) might involve the pathogenesis of pulpal inflammation via induction of IL-8 production. Prostaglandins F 13-16 C-X-C motif chemokine ligand 8 Homo sapiens 96-100 19131342-5 2009 AT-56 inhibited the production of PGD(2) by L-PGDS-expressing human TE-671 cells after stimulation with Ca(2+) ionophore (5 microm A23187) with an IC(50) value of about 3 microm without affecting their production of PGE(2) and PGF(2alpha) but had no effect on the PGD(2) production by H-PGDS-expressing human megakaryocytes. Prostaglandins F 227-230 prostaglandin D2 synthase Homo sapiens 44-50 18983989-9 2009 Despite the differences in the dehydrogenase activities between CHCR1 and CHCR2, PGE(2) reductase activities of the two enzymes were similar, and PGF(2alpha) was predominantly produced from PGE(2) as a result of the PG 9-keto reductase activity. Prostaglandins F 146-149 carbonyl reductase 2 Cricetulus griseus 74-79 18505470-3 2009 Furthermore, we demonstrate that targeting of ZIPK to the actin filaments, as observed upon PGF-2alpha stimulation, is inhibited by the presence of a cell permeant Par-4 decoy peptide. Prostaglandins F 92-95 death associated protein kinase 3 Homo sapiens 46-50 18505470-3 2009 Furthermore, we demonstrate that targeting of ZIPK to the actin filaments, as observed upon PGF-2alpha stimulation, is inhibited by the presence of a cell permeant Par-4 decoy peptide. Prostaglandins F 92-95 pro-apoptotic WT1 regulator Homo sapiens 164-169 19010312-8 2009 In addition, formation of PGF(2) epimers would activate F prostanoid receptors and deprive PPARgamma of its putative anti-proliferative PGJ(2) ligands. Prostaglandins F 26-29 peroxisome proliferator activated receptor gamma Homo sapiens 91-100 18988674-7 2009 The results indicated changes in expression of genes favorable to PGF(2alpha) action during the late to very late luteal phase, and expressions of many of these genes were regulated in an opposite manner by exogenous hCG treatment. Prostaglandins F 66-69 hypertrichosis 2 (generalised, congenital) Homo sapiens 217-220 18988674-8 2009 Collectively, the findings suggest that curtailment of expression of downstream LH-target genes possibly through PGF(2alpha) action on the CL is among the mechanisms underlying cross talk between the luteotropic and luteolytic signaling pathways that result in the cessation of luteal function, but hCG is likely to abrogate the PGF(2alpha)-responsive gene expression changes resulting in luteal rescue crucial for the maintenance of early pregnancy. Prostaglandins F 113-116 hypertrichosis 2 (generalised, congenital) Homo sapiens 299-302 19358934-7 2009 Conversely, ovarian COX-1 expression was increased 135% with stearidonic acid ingestion associated with increased PGF(2alpha) without altering PGE(2) or ova release. Prostaglandins F 114-117 prostaglandin-endoperoxide synthase 1 Rattus norvegicus 20-25 19250190-5 2009 AKR1C3 also acts as a prostaglandin (PG) F synthase and forms PGF(2alpha) and 11beta-PGF(2alpha), which stimulate the FP receptor and prevent the activation of PPARgamma by PGJ(2) ligands. Prostaglandins F 62-65 aldo-keto reductase family 1 member C3 Homo sapiens 0-6 19250190-5 2009 AKR1C3 also acts as a prostaglandin (PG) F synthase and forms PGF(2alpha) and 11beta-PGF(2alpha), which stimulate the FP receptor and prevent the activation of PPARgamma by PGJ(2) ligands. Prostaglandins F 62-65 peroxisome proliferator activated receptor gamma Homo sapiens 160-169 18832100-2 2009 The primary action of IFNtau is believed to be mediated through inhibition of prostaglandin F(2alpha) (PGF(2alpha)) released from the endometrial epithelial cells in response to oxytocin (OT). Prostaglandins F 78-93 interferon tau-2 Bos taurus 22-28 18832100-2 2009 The primary action of IFNtau is believed to be mediated through inhibition of prostaglandin F(2alpha) (PGF(2alpha)) released from the endometrial epithelial cells in response to oxytocin (OT). Prostaglandins F 103-106 interferon tau-2 Bos taurus 22-28 18832100-8 2009 Interestingly, IFNtau (20 ng/ml) significantly reduced OT-induced PGF(2alpha) accumulation, but surprisingly, the effect was not mediated through down-regulation of either OTR or COX2. Prostaglandins F 66-69 interferon tau-2 Bos taurus 15-21 18832100-11 2009 Because IFNtau reduced OT-stimulated PGF(2alpha) accumulation within 3 h, the mechanism likely involves a direct interference at the level of the OT signaling or transcription in addition to the down-regulation of OTR observed in vivo. Prostaglandins F 37-40 interferon tau-2 Bos taurus 8-14 18809207-11 2009 Secretion of prostaglandin F(2)alpha was increased and that of 6-keto-PGF(1)alpha decreased by endothelin-1 in vitro. Prostaglandins F 13-28 endothelin 1 Bos taurus 95-107 19237150-6 2009 RESULTS: PGE(2) and PGF(2alpha) treatment of OC-CM cells significantly increased Nur77 mRNA expression in a time- and dose-dependent fashion. Prostaglandins F 20-23 nuclear receptor subfamily 4, group A, member 1 Mus musculus 81-86 19237150-9 2009 Direct inhibition of the PKA, PKC and intracellular calcium pathways abrogated Nur77 gene expression induced by OC-CM cell treatment with PGE(2) and PGF(2alpha). Prostaglandins F 149-152 nuclear receptor subfamily 4, group A, member 1 Mus musculus 79-84 19010934-1 2009 Here, we show that three enzymes belonging to the 1B group of the aldo-keto reductase (AKR) superfamily, i.e., human placental aldose reductase (AKR1B1), mouse kidney aldose reductase (AKR1B3) and mouse vas deferens protein (AKR1B7), catalyse the reduction of prostaglandin (PG) H(2), a common intermediate of various prostanoids, to form PGF(2alpha) in the presence of NADPH. Prostaglandins F 339-342 aldo-keto reductase family 1 member B Homo sapiens 127-143 19010934-1 2009 Here, we show that three enzymes belonging to the 1B group of the aldo-keto reductase (AKR) superfamily, i.e., human placental aldose reductase (AKR1B1), mouse kidney aldose reductase (AKR1B3) and mouse vas deferens protein (AKR1B7), catalyse the reduction of prostaglandin (PG) H(2), a common intermediate of various prostanoids, to form PGF(2alpha) in the presence of NADPH. Prostaglandins F 339-342 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 167-183 19010934-2 2009 AKR1B1, AKR1B3 and AKR1B7 displayed higher affinities for PGH(2) (K(m) = 1.9, 9.3 and 3.8 microM, respectively) and V(max) values (26, 53 and 44 nmol/min/mg protein, respectively) than did the human lung PGF(2alpha) synthase (AKR1C3; 18 microM and 4 nmol/min/mg protein, respectively). Prostaglandins F 204-207 aldo-keto reductase family 1 member B Homo sapiens 0-6 19010934-2 2009 AKR1B1, AKR1B3 and AKR1B7 displayed higher affinities for PGH(2) (K(m) = 1.9, 9.3 and 3.8 microM, respectively) and V(max) values (26, 53 and 44 nmol/min/mg protein, respectively) than did the human lung PGF(2alpha) synthase (AKR1C3; 18 microM and 4 nmol/min/mg protein, respectively). Prostaglandins F 204-207 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 8-14 19010934-2 2009 AKR1B1, AKR1B3 and AKR1B7 displayed higher affinities for PGH(2) (K(m) = 1.9, 9.3 and 3.8 microM, respectively) and V(max) values (26, 53 and 44 nmol/min/mg protein, respectively) than did the human lung PGF(2alpha) synthase (AKR1C3; 18 microM and 4 nmol/min/mg protein, respectively). Prostaglandins F 204-207 aldo-keto reductase family 1, member B7 Mus musculus 19-25 19010934-3 2009 The PGF(2alpha) synthase activity of AKR1B1 and AKR1B3 was efficiently inhibited by two AKR inhibitors, tolrestat (K(i) = 3.6 and 0.26 microM, respectively) and sorbinil (K(i) = 21.7 and 0.89 microM, respectively), in a non-competitive or mixed-type manner, whereas that of AKR1B7 was not sensitive to these inhibitors (K(i) = 9.2 and 18 mM, respectively). Prostaglandins F 4-7 aldo-keto reductase family 1 member B Homo sapiens 37-43 19010934-3 2009 The PGF(2alpha) synthase activity of AKR1B1 and AKR1B3 was efficiently inhibited by two AKR inhibitors, tolrestat (K(i) = 3.6 and 0.26 microM, respectively) and sorbinil (K(i) = 21.7 and 0.89 microM, respectively), in a non-competitive or mixed-type manner, whereas that of AKR1B7 was not sensitive to these inhibitors (K(i) = 9.2 and 18 mM, respectively). Prostaglandins F 4-7 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 48-54 19010934-3 2009 The PGF(2alpha) synthase activity of AKR1B1 and AKR1B3 was efficiently inhibited by two AKR inhibitors, tolrestat (K(i) = 3.6 and 0.26 microM, respectively) and sorbinil (K(i) = 21.7 and 0.89 microM, respectively), in a non-competitive or mixed-type manner, whereas that of AKR1B7 was not sensitive to these inhibitors (K(i) = 9.2 and 18 mM, respectively). Prostaglandins F 4-7 aldo-keto reductase family 1, member B7 Mus musculus 274-280 19091535-1 2009 This study investigates the impact of genetic variation in the cyclooxygenase-1 (COX-1) gene on formation of the vasoconstrictive, pro-inflammatory prostaglandin F(2)(alpha) (PGF(2)(alpha)) and development of cardiovascular disease (CVD). Prostaglandins F 148-163 prostaglandin-endoperoxide synthase 1 Homo sapiens 63-79 19096033-10 2009 Human renal arteries also showed thromboxane-prostanoid receptor-mediated ACh- or PGF(2alpha)-induced contractions and COX-2-dependent release of PGF(2alpha). Prostaglandins F 146-149 mitochondrially encoded cytochrome c oxidase II Homo sapiens 119-124 19096033-11 2009 The present study demonstrates that PGF(2alpha), derived from COX-2, which is localized primarily in the endothelium, is the most likely EDCF underlying endothelium-dependent, thromboxane-prostanoid receptor-mediated contractions to ACh in hamster aortae. Prostaglandins F 36-39 mitochondrially encoded cytochrome c oxidase II Homo sapiens 62-67 19201889-4 2009 PGE(2)-induced mucin production has been well studied, but the effect of PGF(2alpha) on mucin production remains poorly understood. Prostaglandins F 73-76 LOC100508689 Homo sapiens 88-93 19201889-5 2009 To elucidate the effect and underlying mechanism of PGF(2alpha) on MUC5AC production, we investigated the signal transduction of PGF(2alpha) associated with this effect using normal human tracheobronchial epithelial cells. Prostaglandins F 52-55 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 67-73 19201889-6 2009 Our results demonstrated that PGF(2alpha) induces MUC5AC overproduction via a signaling cascade involving protein kinase C, ERK, p90 ribosomal S6 protein kinase, and CREB. Prostaglandins F 30-33 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 50-56 19201889-6 2009 Our results demonstrated that PGF(2alpha) induces MUC5AC overproduction via a signaling cascade involving protein kinase C, ERK, p90 ribosomal S6 protein kinase, and CREB. Prostaglandins F 30-33 cellular inhibitor of PP2A Homo sapiens 129-132 19201889-6 2009 Our results demonstrated that PGF(2alpha) induces MUC5AC overproduction via a signaling cascade involving protein kinase C, ERK, p90 ribosomal S6 protein kinase, and CREB. Prostaglandins F 30-33 cAMP responsive element binding protein 1 Homo sapiens 166-170 19201889-7 2009 The regulation of PGF(2alpha)-induced MUC5AC expression by CREB was further confirmed by cAMP response element-dependent MUC5AC promoter activity and by interaction between CREB and MUC5AC promoter. Prostaglandins F 18-21 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 38-44 19201889-7 2009 The regulation of PGF(2alpha)-induced MUC5AC expression by CREB was further confirmed by cAMP response element-dependent MUC5AC promoter activity and by interaction between CREB and MUC5AC promoter. Prostaglandins F 18-21 cAMP responsive element binding protein 1 Homo sapiens 59-63 19201889-7 2009 The regulation of PGF(2alpha)-induced MUC5AC expression by CREB was further confirmed by cAMP response element-dependent MUC5AC promoter activity and by interaction between CREB and MUC5AC promoter. Prostaglandins F 18-21 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 121-127 19201889-7 2009 The regulation of PGF(2alpha)-induced MUC5AC expression by CREB was further confirmed by cAMP response element-dependent MUC5AC promoter activity and by interaction between CREB and MUC5AC promoter. Prostaglandins F 18-21 cAMP responsive element binding protein 1 Homo sapiens 173-177 19201889-7 2009 The regulation of PGF(2alpha)-induced MUC5AC expression by CREB was further confirmed by cAMP response element-dependent MUC5AC promoter activity and by interaction between CREB and MUC5AC promoter. Prostaglandins F 18-21 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 121-127 18703136-2 2008 Our data show that PGF(2alpha) up-regulates Cox-2 expression both at the mRNA and protein level, indicating that activation of FP-R in NRK fibroblasts induces a positive feedback loop in the production PGF(2alpha). Prostaglandins F 19-22 cytochrome c oxidase II, mitochondrial Rattus norvegicus 44-49 18703136-2 2008 Our data show that PGF(2alpha) up-regulates Cox-2 expression both at the mRNA and protein level, indicating that activation of FP-R in NRK fibroblasts induces a positive feedback loop in the production PGF(2alpha). Prostaglandins F 202-205 cytochrome c oxidase II, mitochondrial Rattus norvegicus 44-49 19091535-1 2009 This study investigates the impact of genetic variation in the cyclooxygenase-1 (COX-1) gene on formation of the vasoconstrictive, pro-inflammatory prostaglandin F(2)(alpha) (PGF(2)(alpha)) and development of cardiovascular disease (CVD). Prostaglandins F 148-163 prostaglandin-endoperoxide synthase 1 Homo sapiens 81-86 19091535-1 2009 This study investigates the impact of genetic variation in the cyclooxygenase-1 (COX-1) gene on formation of the vasoconstrictive, pro-inflammatory prostaglandin F(2)(alpha) (PGF(2)(alpha)) and development of cardiovascular disease (CVD). Prostaglandins F 148-163 placental growth factor Homo sapiens 175-178 18644394-4 2008 Contractile responses mediated by 5-HT(1B) receptors may be increased in blood vessels with damaged endothelium, but may also be augmented in the presence of low concentrations of other vasoconstrictors such as thromboxane A(2), endothelin-1, prostaglandin F(2alpha), angiotensin II, histamine, noradrenaline, phenylephrine or KCl. Prostaglandins F 243-258 5-hydroxytryptamine receptor 1B Homo sapiens 34-41 18834901-7 2008 LC-MS/MS analysis of brain prostaglandin profile in COX-2(-/-) mice demonstrated a significant increase in PGF(2alpha), TXB(2), PGE(2) and PGD(2) expression 1h after administration of an excitotoxic dose of KA, but not of NMDA. Prostaglandins F 107-110 cytochrome c oxidase II, mitochondrial Mus musculus 52-57 18703674-7 2008 Over-expression of p53 resulted in reduced accumulation of a marker of proliferation (cyclin B1), P(4), and PGF secretion and increased OT and PGE secretion. Prostaglandins F 108-111 tumor protein p53 Homo sapiens 19-22 19092986-11 2008 TNF inversely affected PGs content in CL: the low dose increased (p<0.01) the PGF(2alpha) level and the high dose increased (p<0.05) PGE(2) level. Prostaglandins F 81-84 tumor necrosis factor Bos taurus 0-3 19092986-15 2008 A low concentration of TNF stimulated in vivo luteolytic factors such as PGF(2alpha), LTC(4) and NO as well as induced apoptosis; whereas the high concentration of TNF stimulated a survival pathway in the bovine CL increasing luteal content of P(4) and PGE(2). Prostaglandins F 73-76 tumor necrosis factor Bos taurus 23-26 18550178-5 2008 Particularly important for labour is PGF(2alpha) and its receptor, PTGFR. Prostaglandins F 37-40 prostaglandin F receptor Homo sapiens 67-72 18638447-2 2008 The expression of NOX1, a catalytic subunit of NADPH oxidase, is induced by various vasoactive factors, including angiotensin II, prostaglandin (PG) F(2alpha), and platelet-derived growth factor (PDGF). Prostaglandins F 130-150 NADPH oxidase 1 Rattus norvegicus 18-22 18507797-1 2008 Prostaglandin F(2 alpha) (PGF(2 alpha)) induces luteolysis in the mid but not in the early luteal phase; despite this, both the early and the mid corpus luteum (CL) have PGF(2 alpha) receptor (FPr). Prostaglandins F 0-15 prostaglandin F receptor Bos taurus 170-191 18507797-1 2008 Prostaglandin F(2 alpha) (PGF(2 alpha)) induces luteolysis in the mid but not in the early luteal phase; despite this, both the early and the mid corpus luteum (CL) have PGF(2 alpha) receptor (FPr). Prostaglandins F 26-29 prostaglandin F receptor Bos taurus 170-191 18507797-5 2008 PGF(2 alpha) stimulated the expression of endothelial NO synthase (eNOS) mRNA at 0.5 h in mix-cultures of EC and SMC with fully-luteinized GC but not with luteinizing GC. Prostaglandins F 0-3 nitric oxide synthase 3 Bos taurus 42-65 18507797-5 2008 PGF(2 alpha) stimulated the expression of endothelial NO synthase (eNOS) mRNA at 0.5 h in mix-cultures of EC and SMC with fully-luteinized GC but not with luteinizing GC. Prostaglandins F 0-3 nitric oxide synthase 3 Bos taurus 67-71 18507797-6 2008 The expression of eNOS mRNA in EC was increased by PGF(2 alpha) at 1 h only when EC was cultured together with fully-luteinized GC but not with luteinizing GC. Prostaglandins F 51-54 nitric oxide synthase 3 Bos taurus 18-22 18638447-8 2008 Electrophoresis mobility shift assays demonstrated that PGF(2alpha) and PDGF augmented the binding of JunB to this sequence. Prostaglandins F 56-59 JunB proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 102-106 18582926-4 2008 The objective of the current study was to determine the effect of dietary inclusion of n-3 PUFA on uterine endometrial mRNA expression of key genes regulating PGF(2alpha) biosynthesis. Prostaglandins F 159-162 PUFA Bos taurus 91-95 18582926-12 2008 Overall the results indicate that key genes regulating uterine PGF(2alpha) biosynthesis can be regulated by dietary inclusion of LC n-3 PUFA which may influence uterine function and embryo survival. Prostaglandins F 63-66 PUFA Bos taurus 136-140 18586382-1 2008 We have previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates interleukin-6 (IL-6), a potent bone resorptive agent, through p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 33-48 interleukin 6 Mus musculus 82-95 18586382-1 2008 We have previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates interleukin-6 (IL-6), a potent bone resorptive agent, through p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 33-48 interleukin 6 Mus musculus 97-101 18586382-1 2008 We have previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates interleukin-6 (IL-6), a potent bone resorptive agent, through p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 33-48 mitogen-activated protein kinase 3 Mus musculus 144-147 18586382-1 2008 We have previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates interleukin-6 (IL-6), a potent bone resorptive agent, through p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 33-48 cyclin-dependent kinase 20 Mus musculus 148-151 18586382-1 2008 We have previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates interleukin-6 (IL-6), a potent bone resorptive agent, through p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 58-61 interleukin 6 Mus musculus 82-95 18586382-1 2008 We have previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates interleukin-6 (IL-6), a potent bone resorptive agent, through p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 58-61 interleukin 6 Mus musculus 97-101 18586382-1 2008 We have previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates interleukin-6 (IL-6), a potent bone resorptive agent, through p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 58-61 mitogen-activated protein kinase 3 Mus musculus 144-147 18586382-1 2008 We have previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates interleukin-6 (IL-6), a potent bone resorptive agent, through p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 58-61 cyclin-dependent kinase 20 Mus musculus 148-151 18586382-2 2008 In the present study, we investigated whether Rho-kinase is implicated in the PGF(2alpha)-stimulated IL-6 synthesis in MC3T3-E1 cells. Prostaglandins F 78-81 Rho-associated coiled-coil containing protein kinase 2 Mus musculus 46-56 18586382-3 2008 PGF(2alpha) time-dependently induced the phosphorylation of myosin phosphatase targeting subunit (MYPT-1), a Rho-kinase substrate. Prostaglandins F 0-3 protein phosphatase 1, regulatory subunit 12A Mus musculus 98-104 18586382-3 2008 PGF(2alpha) time-dependently induced the phosphorylation of myosin phosphatase targeting subunit (MYPT-1), a Rho-kinase substrate. Prostaglandins F 0-3 Rho-associated coiled-coil containing protein kinase 2 Mus musculus 109-119 18586382-4 2008 Y27632, a specific Rho-kinase inhibitor, significantly reduced the PGF(2alpha)-stimulated IL-6 synthesis as well as the MYPT-1 phosphorylation. Prostaglandins F 67-70 Rho-associated coiled-coil containing protein kinase 2 Mus musculus 19-29 18586382-4 2008 Y27632, a specific Rho-kinase inhibitor, significantly reduced the PGF(2alpha)-stimulated IL-6 synthesis as well as the MYPT-1 phosphorylation. Prostaglandins F 67-70 interleukin 6 Mus musculus 90-94 18586382-5 2008 Fasudil, another inhibitor of Rho-kinase, suppressed the PGF(2alpha)-stimulated IL-6 synthesis. Prostaglandins F 57-60 Rho-associated coiled-coil containing protein kinase 2 Mus musculus 30-40 18586382-5 2008 Fasudil, another inhibitor of Rho-kinase, suppressed the PGF(2alpha)-stimulated IL-6 synthesis. Prostaglandins F 57-60 interleukin 6 Mus musculus 80-84 18586382-7 2008 SB203580 and BIRB0796, potent inhibitors of p38 MAP kinase, suppressed the IL-6 synthesis induced by PGF(2alpha). Prostaglandins F 101-104 mitogen-activated protein kinase 14 Mus musculus 44-47 18586382-7 2008 SB203580 and BIRB0796, potent inhibitors of p38 MAP kinase, suppressed the IL-6 synthesis induced by PGF(2alpha). Prostaglandins F 101-104 interleukin 6 Mus musculus 75-79 18586382-9 2008 Y27632 as well as fasudil attenuated the PGF(2alpha)-induced phosphorylation of p38 MAP kinase. Prostaglandins F 41-44 mitogen-activated protein kinase 14 Mus musculus 80-83 18586382-10 2008 These results strongly suggest that Rho-kinase regulates PGF(2alpha)-stimulated IL-6 synthesis via p38 MAP kinase activation in osteoblasts. Prostaglandins F 57-60 Rho-associated coiled-coil containing protein kinase 2 Mus musculus 36-46 18586382-10 2008 These results strongly suggest that Rho-kinase regulates PGF(2alpha)-stimulated IL-6 synthesis via p38 MAP kinase activation in osteoblasts. Prostaglandins F 57-60 interleukin 6 Mus musculus 80-84 18586382-10 2008 These results strongly suggest that Rho-kinase regulates PGF(2alpha)-stimulated IL-6 synthesis via p38 MAP kinase activation in osteoblasts. Prostaglandins F 57-60 mitogen-activated protein kinase 14 Mus musculus 99-102 19138967-7 2008 Amounts of PGE1, PGE2, and PGF(2alpha), known substrates of 15-PGDH, were markedly increased whereas levels of 13,14-dihydro-15-keto-PGE2, a catabolic product of PGE2, were markedly reduced in NSCLC compared with normal lung. Prostaglandins F 27-30 hydroxyprostaglandin dehydrogenase 15 (NAD) Mus musculus 60-67 18272855-13 2008 Treatment with bST increased IGF-I in low-BC cows, and IGF-I was correlated with the diameter of the largest follicle 1 d after CIDR-PGF(2alpha). Prostaglandins F 133-136 IGFI Bos taurus 55-60 18638447-9 2008 PD98059, an inhibitor of MAPK/ERK kinase, suppressed the expression of JunB induced by PGF(2alpha) or PDGF. Prostaglandins F 87-90 mitogen activated protein kinase 3 Rattus norvegicus 25-29 18638447-9 2008 PD98059, an inhibitor of MAPK/ERK kinase, suppressed the expression of JunB induced by PGF(2alpha) or PDGF. Prostaglandins F 87-90 mitogen activated protein kinase 3 Rattus norvegicus 30-33 18638447-9 2008 PD98059, an inhibitor of MAPK/ERK kinase, suppressed the expression of JunB induced by PGF(2alpha) or PDGF. Prostaglandins F 87-90 JunB proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 71-75 18638111-8 2008 The embryo is recognized through its secretion of interferon tau (IFNT), which suppresses luteolytic pulses of prostaglandin F(2 alpha). Prostaglandins F 111-126 interferon tau-2 Bos taurus 50-64 18638111-8 2008 The embryo is recognized through its secretion of interferon tau (IFNT), which suppresses luteolytic pulses of prostaglandin F(2 alpha). Prostaglandins F 111-126 interferon tau-2 Bos taurus 66-70 18638129-5 2008 A 17 kDa cationic protein identified as a secretory phospholipase A2 (sPLA2) type IIA was detected bound to normal capsules but increased substantially in response to PGF(2 alpha). Prostaglandins F 167-170 phospholipase A2 group IIA Equus caballus 42-68 18638129-5 2008 A 17 kDa cationic protein identified as a secretory phospholipase A2 (sPLA2) type IIA was detected bound to normal capsules but increased substantially in response to PGF(2 alpha). Prostaglandins F 167-170 phospholipase A2 group IIA Equus caballus 70-75 18638129-7 2008 After administration of PGF(2 alpha) one immunoreactive form of uteroglobin was preferentially increased. Prostaglandins F 24-27 secretoglobin Equus caballus 64-75 18395968-6 2008 The PPAR-independent effect of PUFA was mimicked by the PKC activators 4beta-PMA and prostaglandin F(2alpha), but was not blocked by the PKC inhibitor RO318425. Prostaglandins F 85-100 PUFA Bos taurus 31-35 18462068-1 2008 Studies were designed to examine the roles of individual protein kinase C (PKC) isoforms in the prostaglandin F(2alpha) (PGF(2alpha))-induced matrix metalloproteinase-2 (MMP-2) secretion from human ciliary muscle cells. Prostaglandins F 96-111 protein kinase C alpha Homo sapiens 75-78 18462068-1 2008 Studies were designed to examine the roles of individual protein kinase C (PKC) isoforms in the prostaglandin F(2alpha) (PGF(2alpha))-induced matrix metalloproteinase-2 (MMP-2) secretion from human ciliary muscle cells. Prostaglandins F 96-111 matrix metallopeptidase 2 Homo sapiens 142-168 18462068-1 2008 Studies were designed to examine the roles of individual protein kinase C (PKC) isoforms in the prostaglandin F(2alpha) (PGF(2alpha))-induced matrix metalloproteinase-2 (MMP-2) secretion from human ciliary muscle cells. Prostaglandins F 96-111 matrix metallopeptidase 2 Homo sapiens 170-175 18462068-1 2008 Studies were designed to examine the roles of individual protein kinase C (PKC) isoforms in the prostaglandin F(2alpha) (PGF(2alpha))-induced matrix metalloproteinase-2 (MMP-2) secretion from human ciliary muscle cells. Prostaglandins F 121-124 matrix metallopeptidase 2 Homo sapiens 142-168 18462068-9 2008 The administration of PGF(2alpha) (1 micromol/L) primarily induced the translocation of PKCepsilon from cytosol to the membrane fraction, as well as increased MMP-2 secretion and ERK1/2 phosphorylation. Prostaglandins F 22-25 protein kinase C epsilon Homo sapiens 88-98 18462068-9 2008 The administration of PGF(2alpha) (1 micromol/L) primarily induced the translocation of PKCepsilon from cytosol to the membrane fraction, as well as increased MMP-2 secretion and ERK1/2 phosphorylation. Prostaglandins F 22-25 matrix metallopeptidase 2 Homo sapiens 159-164 18462068-9 2008 The administration of PGF(2alpha) (1 micromol/L) primarily induced the translocation of PKCepsilon from cytosol to the membrane fraction, as well as increased MMP-2 secretion and ERK1/2 phosphorylation. Prostaglandins F 22-25 mitogen-activated protein kinase 3 Homo sapiens 179-185 18462068-11 2008 The PGF(2alpha)-induced secretion of MMP-2 was also blocked by pretreatment with the PKCepsilon-selective peptide translocation inhibitor, EAVSLKPT, or the transfection of siRNA-targeting PKCepsilon. Prostaglandins F 4-7 matrix metallopeptidase 2 Homo sapiens 37-42 18462068-11 2008 The PGF(2alpha)-induced secretion of MMP-2 was also blocked by pretreatment with the PKCepsilon-selective peptide translocation inhibitor, EAVSLKPT, or the transfection of siRNA-targeting PKCepsilon. Prostaglandins F 4-7 protein kinase C epsilon Homo sapiens 85-95 18462068-11 2008 The PGF(2alpha)-induced secretion of MMP-2 was also blocked by pretreatment with the PKCepsilon-selective peptide translocation inhibitor, EAVSLKPT, or the transfection of siRNA-targeting PKCepsilon. Prostaglandins F 4-7 protein kinase C epsilon Homo sapiens 188-198 18612190-1 2008 Prostaglandin F(2alpha) (PGF(2alpha)) stimulates hypertrophic growth of neonatal rat cardiac myocytes, a feature of which includes downregulation of the Ca(2+)-ATPase (SERCA2), a major Ca(2+) transport protein in SR. Prostaglandins F 0-15 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Rattus norvegicus 168-174 18316157-2 2008 In the present study, we investigated the effect of PGE(2) and PGF(2alpha) on the expression of COX-2 via the FP receptor in endometrial adenocarcinoma cells stably expressing the FP receptor (FPS cells). Prostaglandins F 63-66 prostaglandin-endoperoxide synthase 2 Homo sapiens 96-101 18316157-3 2008 Using chemical inhibitors of intracellular signaling pathways, reporter gene assays and quantitative RT-PCR analysis, we show that PGE(2) and PGF(2alpha) can mobilize inositol 1,4,5-trisphosphate, induce ERK1/2 phosphorylation via the phospholipase Cbeta-protein kinase A-epidermal growth factor receptor pathway and induce cyclooxygenase-2 (COX-2) expression via the FP receptor. Prostaglandins F 142-145 mitogen-activated protein kinase 3 Homo sapiens 204-210 18316157-3 2008 Using chemical inhibitors of intracellular signaling pathways, reporter gene assays and quantitative RT-PCR analysis, we show that PGE(2) and PGF(2alpha) can mobilize inositol 1,4,5-trisphosphate, induce ERK1/2 phosphorylation via the phospholipase Cbeta-protein kinase A-epidermal growth factor receptor pathway and induce cyclooxygenase-2 (COX-2) expression via the FP receptor. Prostaglandins F 142-145 prostaglandin-endoperoxide synthase 2 Homo sapiens 324-340 18316157-3 2008 Using chemical inhibitors of intracellular signaling pathways, reporter gene assays and quantitative RT-PCR analysis, we show that PGE(2) and PGF(2alpha) can mobilize inositol 1,4,5-trisphosphate, induce ERK1/2 phosphorylation via the phospholipase Cbeta-protein kinase A-epidermal growth factor receptor pathway and induce cyclooxygenase-2 (COX-2) expression via the FP receptor. Prostaglandins F 142-145 prostaglandin-endoperoxide synthase 2 Homo sapiens 342-347 18316157-4 2008 In addition we show that the PGE(2) or PGF(2alpha)-regulation of COX-2 via the FP receptor is mediated via the cAMP response element (CRE) binding site on the COX-2 promoter. Prostaglandins F 39-42 prostaglandin-endoperoxide synthase 2 Homo sapiens 65-70 18316157-4 2008 In addition we show that the PGE(2) or PGF(2alpha)-regulation of COX-2 via the FP receptor is mediated via the cAMP response element (CRE) binding site on the COX-2 promoter. Prostaglandins F 39-42 prostaglandin-endoperoxide synthase 2 Homo sapiens 159-164 17968320-3 2008 We demonstrate that prostaglandin (PG) F(2alpha) stimulation rapidly increases the capacity of Ishikawa cells stably expressing the F-prostanoid receptor (FPS) to adhere to vitronectin. Prostaglandins F 20-40 vitronectin Homo sapiens 173-184 18419601-6 2008 Importantly, spinal cords and primary spinal cord cells derived from mPGES-1-deficient mice showed a redirection of the PGE(2) synthesis to PGD(2), PGF(2alpha) and 6-keto-PGF(1alpha) (stable metabolite of PGI(2)). Prostaglandins F 148-151 prostaglandin E synthase Mus musculus 69-76 18612190-1 2008 Prostaglandin F(2alpha) (PGF(2alpha)) stimulates hypertrophic growth of neonatal rat cardiac myocytes, a feature of which includes downregulation of the Ca(2+)-ATPase (SERCA2), a major Ca(2+) transport protein in SR. Prostaglandins F 25-28 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Rattus norvegicus 168-174 18612190-2 2008 The molecular mechanisms by which PGF(2alpha) inhibits SERCA2 gene expression remain unknown. Prostaglandins F 34-37 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Rattus norvegicus 55-61 18612190-3 2008 We determined the cis-regulatory elements responsible for the regulation of the SERCA2 gene expression in cultured neonatal rat cardiac myocytes exposed to PGF(2alpha). Prostaglandins F 156-159 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Rattus norvegicus 80-86 18612190-6 2008 PGF(2alpha) reduced the SERCA2 mRNA levels in a time- and dose-dependent manner in cultured rat cardiac myocytes. Prostaglandins F 0-3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Rattus norvegicus 24-30 18612190-7 2008 Transient transfection analyses showed that PGF(2alpha) -responsive elements are located between -284 and -72 of the SERCA2 promoter, which contains G+C-rich sequences homologous to Sp1, Egr-1 and AP2-binding sites. Prostaglandins F 44-47 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Rattus norvegicus 117-123 18612190-7 2008 Transient transfection analyses showed that PGF(2alpha) -responsive elements are located between -284 and -72 of the SERCA2 promoter, which contains G+C-rich sequences homologous to Sp1, Egr-1 and AP2-binding sites. Prostaglandins F 44-47 early growth response 1 Rattus norvegicus 187-192 18612190-8 2008 PGF(2alpha) significantly increased Egr-1 expression, and overexpression of Egr-1 largely reduced the transcription of the SERCA2 gene. Prostaglandins F 0-3 early growth response 1 Rattus norvegicus 36-41 18612190-9 2008 Egr-1 antisense oligonucleotides blocked the PGF(2alpha) -mediated decrease in SERCA2 mRNA expression. Prostaglandins F 45-48 early growth response 1 Rattus norvegicus 0-5 18612190-9 2008 Egr-1 antisense oligonucleotides blocked the PGF(2alpha) -mediated decrease in SERCA2 mRNA expression. Prostaglandins F 45-48 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Rattus norvegicus 79-85 18612190-10 2008 Furthermore, inhibitors for either genistein-sensitive tyrosine kinase or p38 MAPK, and dominant negative forms of either Ras or Rac, prevented PGF(2alpha) -induced repression of SERCA2 mRNA levels. Prostaglandins F 144-147 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Rattus norvegicus 179-185 18612190-11 2008 These results suggest that Egr-1, as well as Ras, Rac, and p38 MAPK, plays a crucial role in the repression of SERCA2 gene expression during PGF(2alpha) -induced cardiac hypertrophy. Prostaglandins F 141-144 early growth response 1 Rattus norvegicus 27-32 18612190-11 2008 These results suggest that Egr-1, as well as Ras, Rac, and p38 MAPK, plays a crucial role in the repression of SERCA2 gene expression during PGF(2alpha) -induced cardiac hypertrophy. Prostaglandins F 141-144 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Rattus norvegicus 111-117 18432307-3 2008 We demonstrated the stimulatory effect of TNF-alpha, IL-1 beta and/or IL-6 on PGF(2 alpha) and PGE(2) secretion by the porcine fetal membranes. Prostaglandins F 78-81 tumor necrosis factor Sus scrofa 42-51 18367512-8 2008 PGF(2)(alpha) stimulated apelin and APJ mRNA expression at 0.5-2 and 2 h respectively, and then the mRNA expression of apelin-APJ was inhibited from 4 h during PGF(2)(alpha)-induced luteolysis. Prostaglandins F 0-3 apelin Bos taurus 25-31 18367512-8 2008 PGF(2)(alpha) stimulated apelin and APJ mRNA expression at 0.5-2 and 2 h respectively, and then the mRNA expression of apelin-APJ was inhibited from 4 h during PGF(2)(alpha)-induced luteolysis. Prostaglandins F 0-3 apelin Bos taurus 119-125 18367512-8 2008 PGF(2)(alpha) stimulated apelin and APJ mRNA expression at 0.5-2 and 2 h respectively, and then the mRNA expression of apelin-APJ was inhibited from 4 h during PGF(2)(alpha)-induced luteolysis. Prostaglandins F 160-163 apelin Bos taurus 119-125 18367512-10 2008 The present study indicated that the apelin-APJ was localized in the smooth muscle cells of intraluteal arterioles, and responded to PGF(2)(alpha) at the periphery of mid-CL in the cow. Prostaglandins F 133-136 apelin Bos taurus 37-43 18178179-2 2008 In kainic acid-induced seizures, the brain largely increases PGD(2), first from COX-1 and later COX-2-induced PGF(2alpha). Prostaglandins F 110-113 cytochrome c oxidase II, mitochondrial Mus musculus 96-101 18178179-12 2008 Intracisternally administered PGF(2alpha) (700 ng), but not PGD(2) (700 ng) or PGE(2) (700 ng) completely alleviated KA-induced seizures potentiated by COX-2 inhibitors, and also reduced KA-induced hippocampal neuronal death aggravated by indomethacin. Prostaglandins F 30-33 cytochrome c oxidase II, mitochondrial Mus musculus 152-157 18178179-15 2008 In summary, pre- or post-treatment with COX-2 inhibitors aggravates KA-induced seizures, which suggests to change the endogenous PGF(2alpha). Prostaglandins F 129-132 cytochrome c oxidase II, mitochondrial Mus musculus 40-45 18032393-5 2008 Phosphorylation of the regulatory subunit of myosin phosphatase (MYPT-1) and of myosin light-chain-20 (MLC20) and translocation of rho-kinase in response to PGF(2 alpha) were also determined. Prostaglandins F 157-160 protein phosphatase 1, regulatory subunit 12A Rattus norvegicus 65-71 18032393-5 2008 Phosphorylation of the regulatory subunit of myosin phosphatase (MYPT-1) and of myosin light-chain-20 (MLC20) and translocation of rho-kinase in response to PGF(2 alpha) were also determined. Prostaglandins F 157-160 myosin light chain 12B Rattus norvegicus 103-108 18032393-6 2008 Nine srcFK were expressed at the mRNA level, including src, fyn, and yes, and PGF(2 alpha) enhanced phosphorylation of three srcFK proteins at tyr-416. Prostaglandins F 78-81 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 5-8 18032393-10 2008 PGF(2 alpha) enhanced phosphorylation of MYPT-1 at thr-697 and thr-855 and of MLC20 at ser-19. Prostaglandins F 0-3 protein phosphatase 1, regulatory subunit 12A Rattus norvegicus 41-47 18032393-10 2008 PGF(2 alpha) enhanced phosphorylation of MYPT-1 at thr-697 and thr-855 and of MLC20 at ser-19. Prostaglandins F 0-3 myosin light chain 12B Rattus norvegicus 78-83 18032393-15 2008 CONCLUSIONS: srcFK are activated by PGF(2 alpha) in the rat pulmonary artery and may contribute to Ca2+-sensitization and contraction via rho-kinase translocation and phosphorylation of MYPT-1. Prostaglandins F 36-39 protein phosphatase 1, regulatory subunit 12A Rattus norvegicus 186-192 18432307-3 2008 We demonstrated the stimulatory effect of TNF-alpha, IL-1 beta and/or IL-6 on PGF(2 alpha) and PGE(2) secretion by the porcine fetal membranes. Prostaglandins F 78-81 interleukin-1 beta Sus scrofa 53-62 18432307-3 2008 We demonstrated the stimulatory effect of TNF-alpha, IL-1 beta and/or IL-6 on PGF(2 alpha) and PGE(2) secretion by the porcine fetal membranes. Prostaglandins F 78-81 interleukin-6 Sus scrofa 70-74 18432307-6 2008 In addition, an increase in PGF(2 alpha) and/or PGE(2) secretion was usually associated with an augmentation of COX-2 protein expression. Prostaglandins F 28-31 prostaglandin-endoperoxide synthase 2 Sus scrofa 112-117 17901226-1 2008 In ruminants, endometrial prostaglandin F(2alpha) (PGF(2alpha)) is the luteolytic hormone. Prostaglandins F 26-41 placental growth factor Homo sapiens 51-54 17911234-12 2008 In both experiments, heifers receiving GnRH 1 on d 15 and 18 had a greater (P < 0.05) occurrence of luteolysis before PGF(2alpha) injection and expression of estrus than heifers treated on d 2, 5, and 10. Prostaglandins F 121-124 gonadotropin releasing hormone 1 Bos taurus 39-45 17911534-2 2008 PGF(2alpha) has been implicated in wound healing and cardiac hypertrophy, which are both known to involve the induction of the immediate-early response gene, early growth response factor-1 (EGR-1). Prostaglandins F 0-3 early growth response 1 Homo sapiens 158-188 18671915-8 2008 In TNF- or spermine-treated endometria, the expression of prostaglandin (PG) E(2) increased in the early and mid-luteal phases, whereas that of PGF(2alpha) increased in the follicular and late luteal phases. Prostaglandins F 144-147 tumor necrosis factor Homo sapiens 3-6 17976072-0 2007 Bovine endothelial cells interact with fully-luteinized, but not luteinizing, granulosa cells in the mRNA expression of endothelin-1 system in response to prostaglandin F(2alpha). Prostaglandins F 155-170 endothelin 1 Bos taurus 120-132 17911534-2 2008 PGF(2alpha) has been implicated in wound healing and cardiac hypertrophy, which are both known to involve the induction of the immediate-early response gene, early growth response factor-1 (EGR-1). Prostaglandins F 0-3 early growth response 1 Homo sapiens 190-195 17911534-3 2008 We hypothesized that activation of the human FP receptor by PGF(2alpha) could induce the expression of EGR-1 and found that 1 muM PGF(2alpha) produced a time-dependent induction of both mRNA and protein expression for EGR-1. Prostaglandins F 60-63 early growth response 1 Homo sapiens 103-108 17911534-3 2008 We hypothesized that activation of the human FP receptor by PGF(2alpha) could induce the expression of EGR-1 and found that 1 muM PGF(2alpha) produced a time-dependent induction of both mRNA and protein expression for EGR-1. Prostaglandins F 60-63 early growth response 1 Homo sapiens 218-223 17911534-3 2008 We hypothesized that activation of the human FP receptor by PGF(2alpha) could induce the expression of EGR-1 and found that 1 muM PGF(2alpha) produced a time-dependent induction of both mRNA and protein expression for EGR-1. Prostaglandins F 130-133 early growth response 1 Homo sapiens 103-108 17911534-3 2008 We hypothesized that activation of the human FP receptor by PGF(2alpha) could induce the expression of EGR-1 and found that 1 muM PGF(2alpha) produced a time-dependent induction of both mRNA and protein expression for EGR-1. Prostaglandins F 130-133 early growth response 1 Homo sapiens 218-223 17911534-5 2008 Thus, induction of EGR-1 expression by PGF(2alpha) was blocked using dominant-negative constructs of Ras and C-Raf and the Raf kinase inhibitor 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)-pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate (BAY43-9006). Prostaglandins F 39-42 early growth response 1 Homo sapiens 19-24 17911534-5 2008 Thus, induction of EGR-1 expression by PGF(2alpha) was blocked using dominant-negative constructs of Ras and C-Raf and the Raf kinase inhibitor 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)-pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate (BAY43-9006). Prostaglandins F 39-42 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 109-114 17911534-5 2008 Thus, induction of EGR-1 expression by PGF(2alpha) was blocked using dominant-negative constructs of Ras and C-Raf and the Raf kinase inhibitor 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)-pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate (BAY43-9006). Prostaglandins F 39-42 zinc fingers and homeoboxes 2 Homo sapiens 111-114 17911534-6 2008 Likewise, the MEK1/2 inhibitor 2"-amino-3"-methoxyflavone (PD98059) blocked the induction of EGR-1 expression by PGF(2alpha). Prostaglandins F 113-116 mitogen-activated protein kinase kinase 1 Homo sapiens 14-20 17911534-6 2008 Likewise, the MEK1/2 inhibitor 2"-amino-3"-methoxyflavone (PD98059) blocked the induction of EGR-1 expression by PGF(2alpha). Prostaglandins F 113-116 early growth response 1 Homo sapiens 93-98 17911534-7 2008 FP receptor stimulation by PGF(2alpha) induced the phosphorylation of C-Raf, MEK1/2, and extracellular signal-regulated kinases 1 and 2, consistent with the activation of a MAP kinase signaling cascade. Prostaglandins F 27-30 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 70-75 17911534-7 2008 FP receptor stimulation by PGF(2alpha) induced the phosphorylation of C-Raf, MEK1/2, and extracellular signal-regulated kinases 1 and 2, consistent with the activation of a MAP kinase signaling cascade. Prostaglandins F 27-30 mitogen-activated protein kinase kinase 1 Homo sapiens 77-83 17911534-7 2008 FP receptor stimulation by PGF(2alpha) induced the phosphorylation of C-Raf, MEK1/2, and extracellular signal-regulated kinases 1 and 2, consistent with the activation of a MAP kinase signaling cascade. Prostaglandins F 27-30 mitogen-activated protein kinase 3 Homo sapiens 89-135 17911534-8 2008 PGF(2alpha) was also found to induce the expression of EGR-1 in rat cardiomyocytes through the activation of endogenous FP receptors. Prostaglandins F 0-3 early growth response 1 Rattus norvegicus 55-60 17911534-9 2008 This induction of EGR-1 expression in cardiomyocytes also involved the activation of Raf and MAP kinase signaling and was dependent on the activation of protein kinase C. This is the first report to show the regulation of EGR-1 expression after PGF(2alpha) activation of FP receptors and suggests that this could be an early event involved in wound healing and cardiac hypertrophy. Prostaglandins F 245-248 early growth response 1 Homo sapiens 18-23 17911534-9 2008 This induction of EGR-1 expression in cardiomyocytes also involved the activation of Raf and MAP kinase signaling and was dependent on the activation of protein kinase C. This is the first report to show the regulation of EGR-1 expression after PGF(2alpha) activation of FP receptors and suggests that this could be an early event involved in wound healing and cardiac hypertrophy. Prostaglandins F 245-248 early growth response 1 Homo sapiens 222-227 17827879-10 2007 During PGF(2alpha)-induced luteolysis, Cx43 mRNA expression appeared to increase, and VE-cadherin and E-cadherin mRNA significantly increased at 24 h. N-cadherin mRNA expression decreased 2 and 4 h after PGF(2alpha) administration. Prostaglandins F 7-10 gap junction protein alpha 1 Bos taurus 39-43 17976072-1 2007 The corpus luteum (CL) undergoes regression by prostaglandin (PG)F(2alpha) from uterus and endothelin-1 (ET-1) plays an important role during luteolysis as a local mediator of PGF(2alpha) in the cow. Prostaglandins F 176-179 endothelin 1 Bos taurus 91-103 17976072-1 2007 The corpus luteum (CL) undergoes regression by prostaglandin (PG)F(2alpha) from uterus and endothelin-1 (ET-1) plays an important role during luteolysis as a local mediator of PGF(2alpha) in the cow. Prostaglandins F 176-179 endothelin 1 Bos taurus 105-109 17976072-7 2007 The data suggest that interactions between BAEC and fully-luteinized GC enhance the capability of BAEC to produce ET-1 in response to PGF(2alpha). Prostaglandins F 134-137 endothelin 1 Bos taurus 114-118 17976072-3 2007 We aimed to examine the relevance of interactions between EC and luteal cells on stimulation of genes which involved ET-1 synthesis by PGF(2alpha). Prostaglandins F 135-138 endothelin 1 Bos taurus 117-121 17976072-6 2007 PGF(2alpha) stimulated the expression of preproET-1 and endothelin converting enzyme-1 mRNA only in the co-cultures of BAEC with fully-luteinized GC, but not with luteinizing GC. Prostaglandins F 0-3 endothelin converting enzyme 1 Bos taurus 56-86 18076476-9 2007 Ang II also increased PGF(2)alpha and PGE(2) levels. Prostaglandins F 22-25 angiotensinogen Rattus norvegicus 0-6 17683809-14 2007 Concomitantly, upon incubation with PGE(2) and PGF(2alpha), an increased expression of COX-2 and activation of p42/p44 MAP kinase were observed in wtNIH3T3 and SPIbetaS262A cells but not in SPIbeta cells. Prostaglandins F 47-50 cytochrome c oxidase II, mitochondrial Mus musculus 87-92 17683809-14 2007 Concomitantly, upon incubation with PGE(2) and PGF(2alpha), an increased expression of COX-2 and activation of p42/p44 MAP kinase were observed in wtNIH3T3 and SPIbetaS262A cells but not in SPIbeta cells. Prostaglandins F 47-50 cyclin-dependent kinase 20 Mus musculus 111-114 17683809-14 2007 Concomitantly, upon incubation with PGE(2) and PGF(2alpha), an increased expression of COX-2 and activation of p42/p44 MAP kinase were observed in wtNIH3T3 and SPIbetaS262A cells but not in SPIbeta cells. Prostaglandins F 47-50 mitogen-activated protein kinase 3 Mus musculus 115-118 17991618-13 2007 Concentrations of PGF(2alpha) were increased in media (P<0.05) of vehicle, AA, LH, or PSPB-treated luteal tissue from non-bred ewes and bred ewes on day 15 and by luteal tissue from bred ewes on days 20 and 30 after which concentrations of PGF(2alpha) in media declined (P< or =0.05) and did not differ (P> or =0.05) from non-bred or bred ewes on days 8, 11, or 13. Prostaglandins F 18-21 pregnancy-associated glycoprotein 1 Bos taurus 89-93 17822438-2 2007 Expression of NOX1, a catalytic subunit of NADPH oxidase, is induced by various vasoactive factors, including angiotensin II, prostaglandin (PG) F(2alpha) and platelet-derived growth factor (PDGF). Prostaglandins F 126-146 NADPH oxidase 1 Rattus norvegicus 14-18 17674023-1 2007 In order to promote better understanding of the physiological roles of prostaglandin F(2alpha) in the mouse testis, we investigated the protein expression and the cellular localization of the enzymes cyclooxygenase and prostaglandin F synthase that are essential for the production of prostaglandin F(2alpha), and the binding site, which is the prostaglandin F(2alpha )receptor (FP). Prostaglandins F 219-234 prostaglandin F receptor Mus musculus 345-377 17881682-7 2007 Pregnancy outcomes based on the PAG ELISA had a high negative predictive value, indicating that the probability of incorrectly administering PGF(2alpha) to pregnant cows would be low if this test were implemented on a commercial dairy. Prostaglandins F 141-144 pregnancy-associated glycoprotein Bos taurus 32-35 17672868-3 2007 In response to doxycycline treatment, COX-2 expression was increased in airway epithelium of COTA mice and whole lung tissue contained a three- to sevenfold increase in prostaglandin E(2) (PGE(2)), prostaglandin D(2) (PGD(2)) thromboxane B(2) (TXB(2)) and 6-Keto prostaglandin F(2alpha) (PGF(2alpha)) compared to wild-type and untreated COTA mice. Prostaglandins F 288-291 prostaglandin-endoperoxide synthase 2 Mus musculus 38-43 17822438-7 2007 Gene silencing of MEF2B by RNA interference significantly suppressed the expression of NOX1, while silencing of activating transcription factor (ATF)-1, previously implicated in up-regulation of NOX1, abolished the PGF(2alpha)- or PDGF-induced expression of MEF2B. Prostaglandins F 215-218 myocyte enhancer factor 2B Rattus norvegicus 18-23 17822438-7 2007 Gene silencing of MEF2B by RNA interference significantly suppressed the expression of NOX1, while silencing of activating transcription factor (ATF)-1, previously implicated in up-regulation of NOX1, abolished the PGF(2alpha)- or PDGF-induced expression of MEF2B. Prostaglandins F 215-218 activating transcription factor 1 Rattus norvegicus 112-151 17822438-7 2007 Gene silencing of MEF2B by RNA interference significantly suppressed the expression of NOX1, while silencing of activating transcription factor (ATF)-1, previously implicated in up-regulation of NOX1, abolished the PGF(2alpha)- or PDGF-induced expression of MEF2B. Prostaglandins F 215-218 NADPH oxidase 1 Rattus norvegicus 195-199 17623049-2 2007 In this study, we show that recombinant IL-18 (rIL-18) also has a direct effect on normal rat chondrocytes maintained in vitro inducing them to produce proinflammatory factors including IL-6, regulated upon activation normal T cell expressed and secreted (RANTES), prostaglandin E(2) (PGE(2)) and prostaglandin F(2alpha) (PGF(2alpha)) in a dose- and time-dependent manner. Prostaglandins F 297-312 interleukin 18 Rattus norvegicus 40-45 17655490-8 2007 PGE(2) (10 microM), PGI(2) (0.01-10 microM), and PGF(2) (10 microM) decreased ALP activity, whereas PGF(2) (0.1 microM) increased ALP activity at day 14. Prostaglandins F 49-52 ATHS Homo sapiens 78-81 17655490-8 2007 PGE(2) (10 microM), PGI(2) (0.01-10 microM), and PGF(2) (10 microM) decreased ALP activity, whereas PGF(2) (0.1 microM) increased ALP activity at day 14. Prostaglandins F 49-52 ATHS Homo sapiens 130-133 17655490-9 2007 PGF(2) (0.01-0.1 microM) and PGI(2) (0.01 microM) upregulated osteopontin gene expression, and PGF(2) (0.01 microM) upregulated alpha1(I)procollagen gene expression at day 4. Prostaglandins F 0-3 secreted phosphoprotein 1 Homo sapiens 62-73 17655490-9 2007 PGF(2) (0.01-0.1 microM) and PGI(2) (0.01 microM) upregulated osteopontin gene expression, and PGF(2) (0.01 microM) upregulated alpha1(I)procollagen gene expression at day 4. Prostaglandins F 0-3 collagen type I alpha 1 chain Homo sapiens 128-148 17655490-10 2007 PGE(2) and PGF(2) (10 microM) at day 4 and PGF(2) (1 microM) at day 14 downregulated runt-related transcription factor-2 gene expression. Prostaglandins F 11-14 RUNX family transcription factor 2 Homo sapiens 85-120 17655490-10 2007 PGE(2) and PGF(2) (10 microM) at day 4 and PGF(2) (1 microM) at day 14 downregulated runt-related transcription factor-2 gene expression. Prostaglandins F 43-46 RUNX family transcription factor 2 Homo sapiens 85-120 17623049-2 2007 In this study, we show that recombinant IL-18 (rIL-18) also has a direct effect on normal rat chondrocytes maintained in vitro inducing them to produce proinflammatory factors including IL-6, regulated upon activation normal T cell expressed and secreted (RANTES), prostaglandin E(2) (PGE(2)) and prostaglandin F(2alpha) (PGF(2alpha)) in a dose- and time-dependent manner. Prostaglandins F 322-325 interleukin 18 Rattus norvegicus 47-53 17623049-2 2007 In this study, we show that recombinant IL-18 (rIL-18) also has a direct effect on normal rat chondrocytes maintained in vitro inducing them to produce proinflammatory factors including IL-6, regulated upon activation normal T cell expressed and secreted (RANTES), prostaglandin E(2) (PGE(2)) and prostaglandin F(2alpha) (PGF(2alpha)) in a dose- and time-dependent manner. Prostaglandins F 322-325 interleukin 6 Rattus norvegicus 186-190 17761889-4 2007 In the present study, expression of above-mentioned PG synthesis enzymes and PG 9-ketoreductase (CBR1), which converts PGE(2) into PGF(2alpha), and the PGE(2)/PGF(2alpha) ratios were investigated in porcine peri- and post-implantation conceptuses. Prostaglandins F 131-134 carbonyl reductase [NADPH] 1 Sus scrofa 97-101 17516915-7 2007 PTGS2 levels were increased by the PKC (protein kinase C) activators 4beta-PMA and PGF(2alpha), and the effects of arachidonic acid, NSAIDs, synthetic PPAR ligands and 4beta-PMA were blocked by PKC inhibitors. Prostaglandins F 83-86 prostaglandin-endoperoxide synthase 2 Bos taurus 0-5 17689974-4 2007 IL-6 had positive relations with CRP, fibrinogen, ox-LDL and PGF(2alpha). Prostaglandins F 61-64 interleukin 6 Homo sapiens 0-4 17478553-3 2007 We investigated a role for PGF(2alpha)-FP receptor interaction in modulating FGF2 expression and signaling using an endometrial adenocarcinoma cell line stably expressing the FP receptor to the levels detected in endometrial adenocarcinomas (FPS cells) and endometrial adenocarcinoma tissue explants. Prostaglandins F 27-30 fibroblast growth factor 2 Homo sapiens 77-81 17478553-4 2007 PGF(2alpha)-FP receptor activation rapidly induced FGF2 mRNA expression, and elevated FGF2 protein expression and secretion into the culture medium in FPS cells and endometrial adenocarcinoma explants. Prostaglandins F 0-3 fibroblast growth factor 2 Homo sapiens 51-55 17478553-4 2007 PGF(2alpha)-FP receptor activation rapidly induced FGF2 mRNA expression, and elevated FGF2 protein expression and secretion into the culture medium in FPS cells and endometrial adenocarcinoma explants. Prostaglandins F 0-3 fibroblast growth factor 2 Homo sapiens 86-90 17478553-5 2007 The effect of PGF(2alpha) on the expression and secretion of FGF2 could be abolished by treatment of FPS cells and endometrial tissues with an FP receptor antagonist (AL8810) and inhibitor of ERK (PD98059). Prostaglandins F 14-17 fibroblast growth factor 2 Homo sapiens 61-65 17478553-5 2007 The effect of PGF(2alpha) on the expression and secretion of FGF2 could be abolished by treatment of FPS cells and endometrial tissues with an FP receptor antagonist (AL8810) and inhibitor of ERK (PD98059). Prostaglandins F 14-17 mitogen-activated protein kinase 1 Homo sapiens 192-195 17681165-6 2007 RESULTS: STC patients had impaired colonic motility index, lower TxA(2) and PGF(2) and higher PGE(2) levels than controls. Prostaglandins F 76-79 stanniocalcin 1 Homo sapiens 9-12 17535999-11 2007 Both basal and hCG-stimulated P release was significantly decreased by ghrelin, which was able to reduce PGE(2) and increase PGF(2alpha) luteal release. Prostaglandins F 125-128 chorionic gonadotropin subunit beta 5 Homo sapiens 15-18 17510528-13 2007 PGF(2 alpha) treatment induced CL regression and subsequent ovulation in 3/4 (75%), 3/3 (100%) and 7/7 (100%) cows in the GnRH21-NCL, GnRH21-CL and GnRH37-CL groups, respectively. Prostaglandins F 0-3 nucleolin Bos taurus 129-132 17623049-2 2007 In this study, we show that recombinant IL-18 (rIL-18) also has a direct effect on normal rat chondrocytes maintained in vitro inducing them to produce proinflammatory factors including IL-6, regulated upon activation normal T cell expressed and secreted (RANTES), prostaglandin E(2) (PGE(2)) and prostaglandin F(2alpha) (PGF(2alpha)) in a dose- and time-dependent manner. Prostaglandins F 297-312 interleukin 18 Rattus norvegicus 47-53 17623049-2 2007 In this study, we show that recombinant IL-18 (rIL-18) also has a direct effect on normal rat chondrocytes maintained in vitro inducing them to produce proinflammatory factors including IL-6, regulated upon activation normal T cell expressed and secreted (RANTES), prostaglandin E(2) (PGE(2)) and prostaglandin F(2alpha) (PGF(2alpha)) in a dose- and time-dependent manner. Prostaglandins F 297-312 interleukin 6 Rattus norvegicus 186-190 17623049-2 2007 In this study, we show that recombinant IL-18 (rIL-18) also has a direct effect on normal rat chondrocytes maintained in vitro inducing them to produce proinflammatory factors including IL-6, regulated upon activation normal T cell expressed and secreted (RANTES), prostaglandin E(2) (PGE(2)) and prostaglandin F(2alpha) (PGF(2alpha)) in a dose- and time-dependent manner. Prostaglandins F 322-325 interleukin 18 Rattus norvegicus 40-45 17287495-8 2007 In each MDS line (microenvironment) within the CL, the local releasing profiles of OXT were positively associated with PGF(2alpha) and EDN1 within the CL in all 18 MDS lines implanted in the six CLs (OXT vs. PGF(2alpha), 50.0%; OXT vs. EDN1, 72.2%; P < 0.05). Prostaglandins F 119-122 oxytocin/neurophysin I prepropeptide Bos taurus 83-86 17287495-8 2007 In each MDS line (microenvironment) within the CL, the local releasing profiles of OXT were positively associated with PGF(2alpha) and EDN1 within the CL in all 18 MDS lines implanted in the six CLs (OXT vs. PGF(2alpha), 50.0%; OXT vs. EDN1, 72.2%; P < 0.05). Prostaglandins F 208-211 oxytocin/neurophysin I prepropeptide Bos taurus 83-86 17287495-10 2007 In the ovarian vein, the peak concentration of PGF(2alpha) increased significantly when the peak of PGF(2alpha) coincided with the peak of OXT after the onset of spontaneous luteolysis (P < 0.05). Prostaglandins F 47-50 oxytocin/neurophysin I prepropeptide Bos taurus 139-142 17287495-11 2007 In conclusion, intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 and PGF(2alpha) within the CL, and thus might be one of the luteal mediators of spontaneous luteolysis in the cow. Prostaglandins F 110-113 oxytocin/neurophysin I prepropeptide Bos taurus 27-30 17499744-5 2007 A combination of TNFalpha and IFN gamma stimulated PGF(2 alpha) synthesis and cytotoxicity (both, P<0.05). Prostaglandins F 51-54 interferon gamma Rattus norvegicus 30-39 17499744-7 2007 The present data suggest that P4 inhibits and TNFalpha and IFN gamma cooperatively stimulate PGF(2 alpha) release by rat luteal cells. Prostaglandins F 93-96 tumor necrosis factor Rattus norvegicus 46-54 17499744-7 2007 The present data suggest that P4 inhibits and TNFalpha and IFN gamma cooperatively stimulate PGF(2 alpha) release by rat luteal cells. Prostaglandins F 93-96 interferon gamma Rattus norvegicus 59-68 17499744-8 2007 They also suggest that luteal cell death induced by TNFalpha/IFN gamma and Fas stimulation seems to occur via distinct signaling pathways involving PGF(2 alpha) production. Prostaglandins F 148-151 tumor necrosis factor Rattus norvegicus 52-60 17499744-8 2007 They also suggest that luteal cell death induced by TNFalpha/IFN gamma and Fas stimulation seems to occur via distinct signaling pathways involving PGF(2 alpha) production. Prostaglandins F 148-151 interferon gamma Rattus norvegicus 61-70 17481558-5 2007 The treatment of preadipocytes with TNFalpha along with calcium ionophore A23187 resulted in the stimulated formation of PGE(2) and PGF(2alpha), attenuating the apoptotic cell death induced by TNFalpha alone. Prostaglandins F 132-135 tumor necrosis factor Mus musculus 36-44 17499744-5 2007 A combination of TNFalpha and IFN gamma stimulated PGF(2 alpha) synthesis and cytotoxicity (both, P<0.05). Prostaglandins F 51-54 tumor necrosis factor Rattus norvegicus 17-25 17138645-4 2007 We then demonstrated that PGF(2alpha) and PGI2, but not PGE2 inhibited GnRH receptor expression by inhibition of phosphoinositide turnover. Prostaglandins F 26-29 gonadotropin releasing hormone receptor Rattus norvegicus 71-84 17192516-3 2007 TNF at 1 microg infused directly into aorta abdominalis increased the level of PGF(2alpha) and decreased the level of progesterone (P4) in the peripheral blood and shortened the estrus cycle. Prostaglandins F 79-82 tumor necrosis factor Bos taurus 0-3 17192516-11 2007 TNF at low concentrations initiates a positive cascade between uterine PGF(2alpha) and various luteolytic factors, including NO, to complete premature luteolysis. Prostaglandins F 71-74 tumor necrosis factor Bos taurus 0-3 17031857-2 2007 We previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 28-43 vascular endothelial growth factor A Mus musculus 94-128 17031857-2 2007 We previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 28-43 vascular endothelial growth factor A Mus musculus 130-134 17031857-2 2007 We previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 28-43 mitogen-activated protein kinase 3 Mus musculus 140-143 17031857-2 2007 We previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 28-43 cyclin-dependent kinase 20 Mus musculus 144-147 17031857-2 2007 We previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 53-56 vascular endothelial growth factor A Mus musculus 94-128 17031857-2 2007 We previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 53-56 vascular endothelial growth factor A Mus musculus 130-134 17031857-2 2007 We previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 53-56 mitogen-activated protein kinase 3 Mus musculus 140-143 17031857-2 2007 We previously reported that prostaglandin F(2alpha) (PGF(2alpha)) stimulates the synthesis of vascular endothelial growth factor (VEGF) via p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 53-56 cyclin-dependent kinase 20 Mus musculus 144-147 17031857-4 2007 The PGF(2alpha)-induced VEGF synthesis was significantly enhanced by EGCG. Prostaglandins F 4-7 vascular endothelial growth factor A Mus musculus 24-28 17031857-7 2007 SB203580, a specific inhibitor of p38 MAP kinase, and SP600125, a specific inhibitor of stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), reduced the PGF(2alpha)-induced VEGF synthesis. Prostaglandins F 168-171 jun proto-oncogene Mus musculus 120-125 17031857-7 2007 SB203580, a specific inhibitor of p38 MAP kinase, and SP600125, a specific inhibitor of stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), reduced the PGF(2alpha)-induced VEGF synthesis. Prostaglandins F 168-171 vascular endothelial growth factor A Mus musculus 188-192 17031857-10 2007 In addition, the PGF(2alpha)-induced phosphorylation of c-Jun was amplified by EGCG. Prostaglandins F 17-20 jun proto-oncogene Mus musculus 56-61 17031857-11 2007 These results strongly suggest that EGCG upregulate PGF(2alpha)-stimulated VEGF synthesis resulting from amplifying activation of SAPK/JNK in osteoblasts. Prostaglandins F 52-55 vascular endothelial growth factor A Mus musculus 75-79 17371983-1 2007 Placenta growth factor (PlGF; formerly PGF), a vascular endothelial growth factor gene family member, is expressed in human implantation sites by maternal uterine NK (uNK) and fetal trophoblast cells. Prostaglandins F 39-42 placental growth factor Homo sapiens 0-22 17371983-1 2007 Placenta growth factor (PlGF; formerly PGF), a vascular endothelial growth factor gene family member, is expressed in human implantation sites by maternal uterine NK (uNK) and fetal trophoblast cells. Prostaglandins F 39-42 placental growth factor Homo sapiens 24-28 17138645-5 2007 PGF(2alpha), but not PGI2 or PGE2, reduced GnRH-induction of LHbeta gene expression, but not the alpha-gonadotropin subunit or the FSHbeta subunit genes. Prostaglandins F 0-3 gonadotropin releasing hormone 1 Rattus norvegicus 43-47 17138645-5 2007 PGF(2alpha), but not PGI2 or PGE2, reduced GnRH-induction of LHbeta gene expression, but not the alpha-gonadotropin subunit or the FSHbeta subunit genes. Prostaglandins F 0-3 luteinizing hormone subunit beta Rattus norvegicus 61-67 17138645-7 2007 Incubations of rat pituitaries with PGF(2alpha), but not PGI2 or PGE2, inhibited GnRH-induced LH secretion, whereas the cyclooxygenase inhibitor, indomethacin, stimulated GnRH-induced LH secretion. Prostaglandins F 36-39 gonadotropin releasing hormone 1 Mus musculus 81-85 17138645-7 2007 Incubations of rat pituitaries with PGF(2alpha), but not PGI2 or PGE2, inhibited GnRH-induced LH secretion, whereas the cyclooxygenase inhibitor, indomethacin, stimulated GnRH-induced LH secretion. Prostaglandins F 36-39 gonadotropin releasing hormone 1 Mus musculus 171-175 17138645-9 2007 The findings have thus elaborated a novel GnRH signaling pathway mediated by PGF(2alpha)-FP and PGI2-IP, which acts through an autocrine/paracrine modality to limit autoregulation of the GnRH receptor and differentially inhibit LH and FSH release. Prostaglandins F 77-80 gonadotropin releasing hormone 1 Rattus norvegicus 42-46 17138645-9 2007 The findings have thus elaborated a novel GnRH signaling pathway mediated by PGF(2alpha)-FP and PGI2-IP, which acts through an autocrine/paracrine modality to limit autoregulation of the GnRH receptor and differentially inhibit LH and FSH release. Prostaglandins F 77-80 gonadotropin releasing hormone receptor Rattus norvegicus 187-200 16947426-6 2007 It is suggested that PGF(2alpha) induces uteroplacental vasoconstriction in the rat, and that ET-1 may take part in mediating this effect, probably via activation of ETA receptor. Prostaglandins F 21-24 endothelin receptor type A Rattus norvegicus 166-169 17160007-6 2007 In addition, insulin significantly increased PGF(2alpha)-production which was inhibited by indomethacin, but not Y-27632. Prostaglandins F 45-48 insulin Cavia porcellus 13-20 17065498-1 2006 PURPOSE: Prostaglandin F(2alpha) analogues, such as latanoprost, may cause a decrease in the extracellular matrices, such as collagen, and changes in fibrillin-1; both are components of the ciliary zonules. Prostaglandins F 9-24 fibrillin 1 Homo sapiens 150-161 17097894-10 2006 Moreover, while leptin, in various concentrations, did not affect PGE(2) and PGF(2alpha) levels, it inhibited the elevation of PGE(2) and PGF(2alpha) concentrations in response to hCG. Prostaglandins F 138-141 hypertrichosis 2 (generalised, congenital) Homo sapiens 180-183 17107518-2 2006 A time-dependent effect of TNFalpha (10 ng/ml) on PGF(2alpha) release was observed in stromal and luminal epithelial cells. Prostaglandins F 50-53 tumor necrosis factor Sus scrofa 27-35 17107518-3 2006 Moreover, TNFalpha increased PGF(2alpha) secretion from both endometrial cell types with effective concentrations of 1 (p < 0.05), 10 and 50 ng/ml (p < 0.01). Prostaglandins F 29-32 tumor necrosis factor Sus scrofa 10-18 17107518-4 2006 The effect of TNFalpha (10 ng/ml) on endometrial PGF(2alpha) and PGE(2) release was compared with OT (100 nmol/l) and LH (100 ng/ml). Prostaglandins F 49-52 tumor necrosis factor Sus scrofa 14-22 17107518-6 2006 In epithelial cells, only TNFalpha was able to stimulate PGF(2alpha) release (p < 0.001). Prostaglandins F 57-60 tumor necrosis factor Sus scrofa 26-34 17107518-9 2006 Summarizing, TNFalpha induces both PGs secretion from cultured porcine endometrium, but preferentially stimulates PGF(2alpha) release from luminal epithelial cells. Prostaglandins F 114-117 tumor necrosis factor Sus scrofa 13-21 17107518-10 2006 Therefore, similarly to OT and LH, TNFalpha may be considered as a potential modulator of endometrial PGF(2alpha) production during luteolysis in the pig. Prostaglandins F 102-105 tumor necrosis factor Sus scrofa 35-43 17065500-7 2006 PGF(2)alpha increased the level of MLC phosphorylation at a constant [Ca(2+)](i). Prostaglandins F 0-3 myosin light chain 1 Sus scrofa 35-38 16815697-11 2006 In the scratched skin of COX-1-deficient mice, PGD2, PGE2, PGI2 and PGF(2 alpha) levels were lower than those of wild-type mice. Prostaglandins F 68-71 cytochrome c oxidase I, mitochondrial Mus musculus 25-30 16855213-8 2006 Similarly, the prostaglandin F(2alpha) (PGF(2alpha))-receptor antagonist AL-8810 reduced SC generation, whereas PGF(2alpha) induced SC-like activity in epithelium-denuded segments. Prostaglandins F 15-30 prostaglandin F receptor Bos taurus 40-61 16564079-10 2006 Potential elevation in Bax due to PGF-analog gel treatment in pregnancy was only significant in relation to normal diestrus during early pregnancy (P < 0.01). Prostaglandins F 34-37 BCL2 associated X, apoptosis regulator Canis lupus familiaris 23-26 16375967-4 2006 Consequently, the expression of cyclooxygenase-II (COX-II) and 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), an enzyme recently shown to be most likely responsible for the production of luteolytic PGF(2alpha) in the endometrium of cyclic cows, was investigated in bovine placentomes. Prostaglandins F 203-206 aldo-keto reductase family 1 member B1 Bos taurus 101-112 16375967-4 2006 Consequently, the expression of cyclooxygenase-II (COX-II) and 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), an enzyme recently shown to be most likely responsible for the production of luteolytic PGF(2alpha) in the endometrium of cyclic cows, was investigated in bovine placentomes. Prostaglandins F 203-206 aldo-keto reductase family 1 member B1 Bos taurus 63-99 16375967-14 2006 Thus, in UTC PGF(2alpha) may be produced via COX-II and 20alpha-HSD/PGFS, but only COX-II may be substantially involved in the control of a putative prepartal placentomal output of luteolytic PGs, whereas 20alpha-HSD/PGFS seems to be expressed in a more constitutive manner. Prostaglandins F 13-16 aldo-keto reductase family 1 member B1 Bos taurus 56-67 16814279-6 2006 Nimesulide or indomethacin administered i.p 30 min prior LPS, IL-1beta, IL-6, TNF-alpha or arachidonic acid reduced the febrile response and PGE(2) or PGF(2alpha) levels in LPS-febrile rats but did not modify PGE(2)-induced fever. Prostaglandins F 151-154 interleukin 1 beta Rattus norvegicus 62-70 16814279-6 2006 Nimesulide or indomethacin administered i.p 30 min prior LPS, IL-1beta, IL-6, TNF-alpha or arachidonic acid reduced the febrile response and PGE(2) or PGF(2alpha) levels in LPS-febrile rats but did not modify PGE(2)-induced fever. Prostaglandins F 151-154 interleukin 6 Rattus norvegicus 72-76 16814279-6 2006 Nimesulide or indomethacin administered i.p 30 min prior LPS, IL-1beta, IL-6, TNF-alpha or arachidonic acid reduced the febrile response and PGE(2) or PGF(2alpha) levels in LPS-febrile rats but did not modify PGE(2)-induced fever. Prostaglandins F 151-154 tumor necrosis factor Rattus norvegicus 78-87 16303279-1 2006 Prostaglandin F(2alpha) (PGF(2alpha)) is the primary luteolysin in the cow, and luteal endothelin-1 (ET-1) interacts with PGF(2alpha) during the process of luteolysis. Prostaglandins F 25-28 endothelin 1 Bos taurus 87-99 16303279-1 2006 Prostaglandin F(2alpha) (PGF(2alpha)) is the primary luteolysin in the cow, and luteal endothelin-1 (ET-1) interacts with PGF(2alpha) during the process of luteolysis. Prostaglandins F 122-125 endothelin 1 Bos taurus 87-99 16960384-4 2006 Exposure of preadipocytes to calcium ionophore A23187 reduced TNF-alpha-induced apoptosis, which was accompanied by increased production of prostaglandins (PGs) E2 and PGF 2alpha. Prostaglandins F 168-171 tumor necrosis factor Mus musculus 62-71 16960384-6 2006 Consistently, NS-398, a COX-2 inhibitor, stimulated TNF-alpha-induced apoptosis, which was reversed by exogenous PGE2 and PGF 2alpha. Prostaglandins F 122-125 cytochrome c oxidase II, mitochondrial Mus musculus 24-29 16960384-6 2006 Consistently, NS-398, a COX-2 inhibitor, stimulated TNF-alpha-induced apoptosis, which was reversed by exogenous PGE2 and PGF 2alpha. Prostaglandins F 122-125 tumor necrosis factor Mus musculus 52-61 16960384-7 2006 These results indicate that endogenous PGE2 and PGF 2alpha synthesized by preadipocytes through the induction of COX-2 can serve as anti-apoptotic factors against apoptosis by TNF-alpha. Prostaglandins F 48-51 cytochrome c oxidase II, mitochondrial Mus musculus 113-118 16960384-7 2006 These results indicate that endogenous PGE2 and PGF 2alpha synthesized by preadipocytes through the induction of COX-2 can serve as anti-apoptotic factors against apoptosis by TNF-alpha. Prostaglandins F 48-51 tumor necrosis factor Mus musculus 176-185 16519664-3 2006 We previously showed that prostaglandin (PG) E(2), PGF(2alpha) or the neuropeptide nociceptin, also called orphanin FQ (N/OFQ) administered intrathecally (i.t.) Prostaglandins F 51-54 prepronociceptin Mus musculus 107-118 16631683-8 2006 Subgroup analysis revealed a significantly greater elevation in IL-6, IL-8, and IL-10 levels in PGF patients (all p < 0.01) versus PLTRE. Prostaglandins F 96-99 interleukin 6 Homo sapiens 64-68 16631683-8 2006 Subgroup analysis revealed a significantly greater elevation in IL-6, IL-8, and IL-10 levels in PGF patients (all p < 0.01) versus PLTRE. Prostaglandins F 96-99 C-X-C motif chemokine ligand 8 Homo sapiens 70-74 16631683-8 2006 Subgroup analysis revealed a significantly greater elevation in IL-6, IL-8, and IL-10 levels in PGF patients (all p < 0.01) versus PLTRE. Prostaglandins F 96-99 interleukin 10 Homo sapiens 80-85 16631683-9 2006 In the PGF group, TNFalpha and IL-10 concentrations were significantly greater in the systemic versus the pulmonary arterial samples (p < 0.05). Prostaglandins F 7-10 tumor necrosis factor Homo sapiens 18-26 16631683-9 2006 In the PGF group, TNFalpha and IL-10 concentrations were significantly greater in the systemic versus the pulmonary arterial samples (p < 0.05). Prostaglandins F 7-10 interleukin 10 Homo sapiens 31-36 16631683-10 2006 CONCLUSIONS: Patients with PLTRE and PGF exhibited graded increases in IL-6, IL-8, and IL-10 concentrations. Prostaglandins F 37-40 interleukin 6 Homo sapiens 71-75 16631683-10 2006 CONCLUSIONS: Patients with PLTRE and PGF exhibited graded increases in IL-6, IL-8, and IL-10 concentrations. Prostaglandins F 37-40 C-X-C motif chemokine ligand 8 Homo sapiens 77-81 16631683-10 2006 CONCLUSIONS: Patients with PLTRE and PGF exhibited graded increases in IL-6, IL-8, and IL-10 concentrations. Prostaglandins F 37-40 interleukin 10 Homo sapiens 87-92 16631683-11 2006 The PGF patients had higher TNFalpha and IL-10 systemic arterial concentrations overall, consistent with the allograft being a source of this cytokine production. Prostaglandins F 4-7 tumor necrosis factor Homo sapiens 28-36 16631683-11 2006 The PGF patients had higher TNFalpha and IL-10 systemic arterial concentrations overall, consistent with the allograft being a source of this cytokine production. Prostaglandins F 4-7 interleukin 10 Homo sapiens 41-46 16629905-1 2006 In astrocytes, the PGF(2alpha) or ionomycin treatment induces the phosphorylation at Ser38 and Ser82 of vimentin, a type III intermediate filament, by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). Prostaglandins F 19-22 vimentin Homo sapiens 104-112 16629905-1 2006 In astrocytes, the PGF(2alpha) or ionomycin treatment induces the phosphorylation at Ser38 and Ser82 of vimentin, a type III intermediate filament, by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). Prostaglandins F 19-22 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 151-196 16629905-1 2006 In astrocytes, the PGF(2alpha) or ionomycin treatment induces the phosphorylation at Ser38 and Ser82 of vimentin, a type III intermediate filament, by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). Prostaglandins F 19-22 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 198-204 16416423-1 2006 Myelin proteolipid protein (PLP), the major protein of mammalian CNS myelin, is a member of the proteolipid gene family (pgf). Prostaglandins F 121-124 proteolipid protein 1 Homo sapiens 0-32 16416423-12 2006 Widespread anti-PLP mAb recognition of neurons suggests a novel potential pathophysiologic mechanism in MS patients, i.e., that anti-PLP antibodies associated with demyelination might simultaneously recognize pgf epitopes in neurons, thereby affecting their functions. Prostaglandins F 209-212 proteolipid protein 1 Homo sapiens 16-19 16416423-12 2006 Widespread anti-PLP mAb recognition of neurons suggests a novel potential pathophysiologic mechanism in MS patients, i.e., that anti-PLP antibodies associated with demyelination might simultaneously recognize pgf epitopes in neurons, thereby affecting their functions. Prostaglandins F 209-212 proteolipid protein 1 Homo sapiens 133-136 16423868-1 2006 In Sertoli epithelial cells, the IL-1beta induces prostaglandins (PG) PGE(2), PGF(2alpha) and PGI(2) (7-, 11-, and 2-fold, respectively), but not PGD(2), production. Prostaglandins F 78-81 interleukin 1 beta Homo sapiens 33-41 16423868-3 2006 IL-1beta-regulated PGE(2) and PGF(2alpha) production and cytokine expression require activation of cyclooxygenase-2 (COX-2) and c-Jun NH(2)-terminal kinase, as shown using specific enzyme inhibition. Prostaglandins F 30-33 interleukin 1 beta Homo sapiens 0-8 16423868-4 2006 PGE(2) and PGF(2alpha) stimulate expression of IL-1alpha, -1beta, and -6, findings consistent with PG involvement in IL signaling within the seminiferous tubule. Prostaglandins F 11-14 interleukin 1 alpha Homo sapiens 47-72 16423868-5 2006 PGE(2) and PGF(2alpha) reverse COX-2-mediated inhibition of IL-1beta induction of cytokine expression and PG production. Prostaglandins F 11-14 mitochondrially encoded cytochrome c oxidase II Homo sapiens 31-36 16423868-5 2006 PGE(2) and PGF(2alpha) reverse COX-2-mediated inhibition of IL-1beta induction of cytokine expression and PG production. Prostaglandins F 11-14 interleukin 1 beta Homo sapiens 60-68 16423868-11 2006 Together, the data indicate an autocrine-amplifying loop involving IL-1beta-regulated Sertoli function mediated by COX-2-induced PGE(2) and PGF(2alpha) production. Prostaglandins F 140-143 interleukin 1 beta Homo sapiens 67-75 16423868-11 2006 Together, the data indicate an autocrine-amplifying loop involving IL-1beta-regulated Sertoli function mediated by COX-2-induced PGE(2) and PGF(2alpha) production. Prostaglandins F 140-143 mitochondrially encoded cytochrome c oxidase II Homo sapiens 115-120 16595720-7 2006 Tumor necrosis factor-alpha (TNF-alpha) reduced DMalpha mRNA concentrations in cultured luteal cells in the presence of LH or PGF(2alpha). Prostaglandins F 126-129 tumor necrosis factor Bos taurus 0-27 16595720-7 2006 Tumor necrosis factor-alpha (TNF-alpha) reduced DMalpha mRNA concentrations in cultured luteal cells in the presence of LH or PGF(2alpha). Prostaglandins F 126-129 tumor necrosis factor Bos taurus 29-38 16595720-7 2006 Tumor necrosis factor-alpha (TNF-alpha) reduced DMalpha mRNA concentrations in cultured luteal cells in the presence of LH or PGF(2alpha). Prostaglandins F 126-129 HLA class II histocompatibility antigen, DM alpha chain Bos taurus 48-55 16759460-6 2006 (2) Urocortin itself did not affect myometrial tension development at all concentrations tested, but it markedly increased PGF(2alpha)-induced myometrial contractility. Prostaglandins F 123-126 urocortin Homo sapiens 4-13 16448621-1 2006 The F(2)-isoprostanes are products of free-radical-induced oxidation of arachidonic acid (AA) that are stereoisomers of prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 120-135 placental growth factor Homo sapiens 145-148 16448621-2 2006 We describe a method for quantitation of several 15-series PGF isomers (15-PGFs) and AA by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS). Prostaglandins F 75-79 placental growth factor Homo sapiens 59-62 16673205-3 2006 In the present study, we investigated the effects of minodronate, a newly developed bisphosphonate, on PGF (2alpha)-induced VEGF synthesis in MC3T3-E1 cells. Prostaglandins F 103-106 vascular endothelial growth factor A Mus musculus 124-128 16378605-3 2006 We report for the first time that the PGD(2) metabolite, 9alpha,11beta-PGF(2), and its stereoisomer, PGF(2alpha), are CRTH2 agonists. Prostaglandins F 71-74 phosphoglycerate dehydrogenase Homo sapiens 38-41 16378605-3 2006 We report for the first time that the PGD(2) metabolite, 9alpha,11beta-PGF(2), and its stereoisomer, PGF(2alpha), are CRTH2 agonists. Prostaglandins F 71-74 prostaglandin D2 receptor 2 Homo sapiens 118-123 16352304-1 2006 Fluid percussion brain injury elevates the cerebrospinal fluid (CSF) concentration of the opioid nociceptin/orphanin FQ (N/OFQ), which potentiates vasoconstriction to the prostaglandins U 46619, a thromboxane A(2) mimic, and prostaglandin (PG)F(2a). Prostaglandins F 225-244 prepronociceptin Sus scrofa 97-107 16352304-1 2006 Fluid percussion brain injury elevates the cerebrospinal fluid (CSF) concentration of the opioid nociceptin/orphanin FQ (N/OFQ), which potentiates vasoconstriction to the prostaglandins U 46619, a thromboxane A(2) mimic, and prostaglandin (PG)F(2a). Prostaglandins F 225-244 prepronociceptin Sus scrofa 108-119 16378246-2 2006 Here we performed cell cycle analyses on HEK cells stably expressing the human FP receptor and found that treatment with PGF(2alpha) delays mitosis and is associated with an increased expression of cyclin B1 and Cdc2 kinase activity. Prostaglandins F 121-124 cyclin B1 Homo sapiens 198-207 16254027-3 2006 In cyclic ewes, loss of PGR allows for increases in estrogen receptor alpha (ESR1) and then oxytocin receptor (OXTR) gene expression followed by oxytocin-induced prostaglandin F(2alpha) pulses. Prostaglandins F 162-177 progesterone receptor Homo sapiens 24-27 16157291-4 2005 These results suggest that PGF synthesized through COX-1 and PGF synthase plays an important physiological role in the kidney and that the expression of COX-2 in kidney is a useful maker for tumorigenesis of the renal call carcinoma in vivo. Prostaglandins F 27-30 mitochondrially encoded cytochrome c oxidase I Homo sapiens 51-56 16157291-4 2005 These results suggest that PGF synthesized through COX-1 and PGF synthase plays an important physiological role in the kidney and that the expression of COX-2 in kidney is a useful maker for tumorigenesis of the renal call carcinoma in vivo. Prostaglandins F 27-30 mitochondrially encoded cytochrome c oxidase II Homo sapiens 153-158 16055481-3 2005 The p38 MAPK inhibitors SB-203580 and SB-202190 strongly inhibited PGF(2alpha)-induced vasoconstriction, with IC(50)s of 1.6 and 1.2 microM, whereas the inactive analog SB-202474 was approximately 30-fold less potent. Prostaglandins F 67-70 mitogen activated protein kinase 14 Rattus norvegicus 4-12 16055481-5 2005 Western blot analysis revealed that PGF(2alpha) (20 microM) increased phosphorylation of p38 MAPK and of heat shock protein 27 (HSP27), and this was abolished by SB-203580 but not by SB-202474 (both 2 microM). Prostaglandins F 36-39 mitogen activated protein kinase 14 Rattus norvegicus 89-97 16055481-5 2005 Western blot analysis revealed that PGF(2alpha) (20 microM) increased phosphorylation of p38 MAPK and of heat shock protein 27 (HSP27), and this was abolished by SB-203580 but not by SB-202474 (both 2 microM). Prostaglandins F 36-39 heat shock protein family B (small) member 1 Rattus norvegicus 105-126 16055481-5 2005 Western blot analysis revealed that PGF(2alpha) (20 microM) increased phosphorylation of p38 MAPK and of heat shock protein 27 (HSP27), and this was abolished by SB-203580 but not by SB-202474 (both 2 microM). Prostaglandins F 36-39 heat shock protein family B (small) member 1 Rattus norvegicus 128-133 16055481-11 2005 We conclude that p38 MAPK contributes to PGF(2alpha)- and hypoxia-induced constriction of rat IPA primarily by antagonizing the underlying Ca(2+)-desensitizing actions of NO. Prostaglandins F 41-44 mitogen activated protein kinase 14 Rattus norvegicus 17-25 17061049-0 2005 Inhibition of prostaglandin F(2alpha) by selective cyclooxygenase 2 inhibitors accounts for reduced rat leukocyte migration. Prostaglandins F 14-29 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 51-67 17061049-8 2005 It can be concluded that COX 2, through PGF(2alpha) release, is the isoform responsible for neutrophil recruitment in the rat model of LPS-induced inflammation. Prostaglandins F 40-43 cytochrome c oxidase II, mitochondrial Rattus norvegicus 25-30 16354411-5 2005 Furthermore, licochalcone A and NS-398 suppressed PGF(2alpha) production by IL-1beta. Prostaglandins F 50-53 interleukin 1 beta Homo sapiens 76-84 16303622-7 2005 On the other hand, IL-1alpha significantly enhanced PGF(2alpha) output throughout the estrous cycle except in the endometrium from the mid luteal stage, with the highest response at the follicular stage (P<0.001). Prostaglandins F 52-55 interleukin 1 alpha Bos taurus 19-28 16303622-8 2005 The treatment of endometrial tissue with IL-1alpha resulted in an increase of the PGE2:PGF(2alpha) ratio at the mid luteal stage, and in a decrease during the late luteal and follicular stages of the estrous cycle. Prostaglandins F 87-90 interleukin 1 alpha Bos taurus 41-50 16303622-12 2005 The overall results suggest that IL-1alpha is produced in bovine endometrium throughout the estrous cycle, and plays some roles not only in maintenance of CL, but also in luteolysis by regulating the local PGE2:PGF(2alpha) ratio in bovine endometrium during the estrous cycle. Prostaglandins F 211-214 interleukin 1 alpha Bos taurus 33-42 16282352-3 2006 We hypothesize that HIF-1 is expressed in human endometrium and that locally synthesized prostaglandins (PGE2 and PGF(2alpha)) regulate HIF-1 activity. Prostaglandins F 114-117 hypoxia inducible factor 1 subunit alpha Homo sapiens 136-141 16246306-5 2005 PGF(2alpha) induced phosphorylation of CREB at serine 133, which is a critical marker of activation, after 5-10min of stimulation in a dose-dependent manner. Prostaglandins F 0-3 cAMP responsive element binding protein 1 Homo sapiens 39-43 16246306-6 2005 Pharmacological inhibition of extracellular signal-regulated protein kinase and p38 mitogen-activated protein kinase (p38-MAPK) suppressed PGF(2alpha)-induced CREB phosphorylation. Prostaglandins F 139-142 mitogen-activated protein kinase 14 Homo sapiens 80-116 16246306-6 2005 Pharmacological inhibition of extracellular signal-regulated protein kinase and p38 mitogen-activated protein kinase (p38-MAPK) suppressed PGF(2alpha)-induced CREB phosphorylation. Prostaglandins F 139-142 mitogen-activated protein kinase 14 Homo sapiens 118-126 16246306-6 2005 Pharmacological inhibition of extracellular signal-regulated protein kinase and p38 mitogen-activated protein kinase (p38-MAPK) suppressed PGF(2alpha)-induced CREB phosphorylation. Prostaglandins F 139-142 cAMP responsive element binding protein 1 Homo sapiens 159-163 16246306-7 2005 Inhibition of epidermal growth factor receptor (EGFR) and mitogen- and stress-activated protein kinase-1 also suppressed PGF(2alpha)-induced CREB phosphorylation. Prostaglandins F 121-124 epidermal growth factor receptor Homo sapiens 14-46 16246306-7 2005 Inhibition of epidermal growth factor receptor (EGFR) and mitogen- and stress-activated protein kinase-1 also suppressed PGF(2alpha)-induced CREB phosphorylation. Prostaglandins F 121-124 epidermal growth factor receptor Homo sapiens 48-52 16246306-7 2005 Inhibition of epidermal growth factor receptor (EGFR) and mitogen- and stress-activated protein kinase-1 also suppressed PGF(2alpha)-induced CREB phosphorylation. Prostaglandins F 121-124 cAMP responsive element binding protein 1 Homo sapiens 141-145 16246306-8 2005 Overexpression of dominant-negative form of CREB (AdCREB M1), of which serine 133 was replaced with alanine, inhibited PGF(2alpha)-induced c-fos mRNA expression as well as hypertrophy of VSMCs [hypertrophy index (microg/10(4)cell); control 8.13, PGF(2alpha) 9.85, AdCREB M1 7.91, and AdCREB M1+PGF(2alpha) 8.43]. Prostaglandins F 119-122 cAMP responsive element binding protein 1 Homo sapiens 44-48 16246306-8 2005 Overexpression of dominant-negative form of CREB (AdCREB M1), of which serine 133 was replaced with alanine, inhibited PGF(2alpha)-induced c-fos mRNA expression as well as hypertrophy of VSMCs [hypertrophy index (microg/10(4)cell); control 8.13, PGF(2alpha) 9.85, AdCREB M1 7.91, and AdCREB M1+PGF(2alpha) 8.43]. Prostaglandins F 119-122 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 139-144 16246306-8 2005 Overexpression of dominant-negative form of CREB (AdCREB M1), of which serine 133 was replaced with alanine, inhibited PGF(2alpha)-induced c-fos mRNA expression as well as hypertrophy of VSMCs [hypertrophy index (microg/10(4)cell); control 8.13, PGF(2alpha) 9.85, AdCREB M1 7.91, and AdCREB M1+PGF(2alpha) 8.43]. Prostaglandins F 246-249 cAMP responsive element binding protein 1 Homo sapiens 44-48 16246306-8 2005 Overexpression of dominant-negative form of CREB (AdCREB M1), of which serine 133 was replaced with alanine, inhibited PGF(2alpha)-induced c-fos mRNA expression as well as hypertrophy of VSMCs [hypertrophy index (microg/10(4)cell); control 8.13, PGF(2alpha) 9.85, AdCREB M1 7.91, and AdCREB M1+PGF(2alpha) 8.43]. Prostaglandins F 246-249 cAMP responsive element binding protein 1 Homo sapiens 44-48 16246306-9 2005 These results suggest that PGF(2alpha) activated CRE-dependent gene transcription through EGFR transactivation, and the CREB pathway plays a critical role in PGF(2alpha)-induced hypertrophy of VSMCs. Prostaglandins F 27-30 epidermal growth factor receptor Homo sapiens 90-94 16246306-9 2005 These results suggest that PGF(2alpha) activated CRE-dependent gene transcription through EGFR transactivation, and the CREB pathway plays a critical role in PGF(2alpha)-induced hypertrophy of VSMCs. Prostaglandins F 158-161 cAMP responsive element binding protein 1 Homo sapiens 120-124 16081677-5 2005 The inhibition of mPGES-1 expression by curcumin shifted the arachidonic acid profile from PGE(2) to PGF(2alpha) and 6-keto-PGF(1alpha) as major metabolites. Prostaglandins F 101-104 prostaglandin E synthase Mus musculus 18-25 16378246-2 2006 Here we performed cell cycle analyses on HEK cells stably expressing the human FP receptor and found that treatment with PGF(2alpha) delays mitosis and is associated with an increased expression of cyclin B1 and Cdc2 kinase activity. Prostaglandins F 121-124 cyclin dependent kinase 1 Homo sapiens 212-216 16105741-2 2005 After testing several immune cytokines, we found that interferon-gamma (IFN-gamma) inhibited responsiveness of adult myocytes to PGF(2alpha). Prostaglandins F 129-132 interferon gamma Rattus norvegicus 54-70 16105741-2 2005 After testing several immune cytokines, we found that interferon-gamma (IFN-gamma) inhibited responsiveness of adult myocytes to PGF(2alpha). Prostaglandins F 129-132 interferon gamma Rattus norvegicus 72-81 16105741-3 2005 The present study was designed to test the hypothesis that IFN-gamma inhibits cardiac hypertrophy induced by PGF(2alpha). Prostaglandins F 109-112 interferon gamma Rattus norvegicus 59-68 16105741-4 2005 Incubation of cultured adult rat cardiac myocytes with PGF(2alpha) caused cell spreading, which was inhibited by IFN-gamma. Prostaglandins F 55-58 interferon gamma Rattus norvegicus 113-122 16105741-9 2005 The results demonstrate that IFN-gamma inhibits the in vitro and in vivo effects of PGF(2alpha) on cardiac hypertrophy, and that the mechanism of action is likely independent of NO production. Prostaglandins F 84-87 interferon gamma Rattus norvegicus 29-38 16105741-10 2005 IFN-gamma also attenuated cardiac hypertrophy induced by pressure overload, suggesting that PGF(2alpha) plays a role in the pathogeneses of this severe type of cardiac hypertrophy. Prostaglandins F 92-95 interferon gamma Rattus norvegicus 0-9 15980881-2 2005 To study the value of granulocyte colony-stimulating factor (G-CSF) in PGF, we retrospectively analyzed 81 episodes of PGF in 66 patients transplanted from 01/94 to 01/99 from an HLA-identical sibling (n = 45) or an unrelated (n = 21) donor. Prostaglandins F 71-74 colony stimulating factor 3 Homo sapiens 61-66 15980881-12 2005 In conclusion, hematological response after 3 days with G-CSF predicted a better survival for patients with PGF after allo-SCT. Prostaglandins F 108-111 colony stimulating factor 3 Homo sapiens 56-61 15890973-4 2005 Norepinephrine-mediated contractions were dependent on both GLUT4 and non-GLUT4 transporters, serotonin (5-HT)-mediated contractions were mainly GLUT4-dependent, and prostaglandin (PG) F(2alpha)-mediated contractions were dependent on non-GLUT4 transporters, whereas indinavir had no effect in GLUT4 knockout vessels. Prostaglandins F 166-186 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 60-65 15653766-9 2005 Western blot analysis demonstrated that PGF(2alpha) and adenosine agonists stimulated p38 MAPK at a concentration of 40 nM in PCA smooth muscle cells. Prostaglandins F 40-43 mitogen-activated protein kinase 14 Homo sapiens 86-89 15713689-4 2005 A small reduction in NGF expression and/or secretion was also observed with adiponectin and prostaglandins PGE(2), PGF(2alpha), and PGI(2). Prostaglandins F 115-118 nerve growth factor Mus musculus 21-24 15653766-11 2005 Addition of NECA and SB-203580 alone or in combination inhibited PGF(2alpha)-induced p38 MAPK. Prostaglandins F 65-68 mitogen-activated protein kinase 14 Homo sapiens 85-88 15601909-7 2005 In conclusion, the evidence indicates that PKCepsilon, an isozyme expressed in corpora lutea with acquired PGF(2alpha) luteolytic capacity, has a regulatory role in the PGF(2alpha)-induced Ca(2+) signaling in luteal steroidogenic cells, and that this in turn may have consequences (at least in part) on the ability of PGF(2alpha) to inhibit LH-stimulated P(4) synthesis at this developmental stage. Prostaglandins F 107-110 protein kinase C epsilon Bos taurus 43-53 15922088-4 2005 The PGF(2alpha)-stimulated phosphorylation of p44/p42 MAP kinase was suppressed by tiludronate. Prostaglandins F 4-7 mitogen-activated protein kinase 3 Mus musculus 46-49 15922088-4 2005 The PGF(2alpha)-stimulated phosphorylation of p44/p42 MAP kinase was suppressed by tiludronate. Prostaglandins F 4-7 cyclin-dependent kinase 20 Mus musculus 50-53 15659710-2 2005 Here, a coculture system was devised to determine if immune cells and PGF 2alpha together affect CCL2 and EDN1 secretion by EC. Prostaglandins F 70-73 C-C motif chemokine 2 Bos taurus 97-101 15659710-2 2005 Here, a coculture system was devised to determine if immune cells and PGF 2alpha together affect CCL2 and EDN1 secretion by EC. Prostaglandins F 70-73 endothelin 1 Bos taurus 106-110 15851572-1 2005 PURPOSE: Studies were designed to evaluate the cellular mechanisms associated with prostaglandin (PG)F(2alpha)-induced matrix metalloproteinase (MMP)-2 secretion from human ciliary muscle (HCM) cells. Prostaglandins F 83-102 matrix metallopeptidase 2 Homo sapiens 119-151 15851572-4 2005 RESULTS: PGF(2alpha) increased the secretion of MMP-2 in a dose-dependent manner with an EC(50) of 2.7 x 10(-8) M. The addition of 1 muM PGF(2alpha) also increased MMP-2 secretion in a time-dependent manner with maximum secretion occurring at 4 hours after administration. Prostaglandins F 9-12 matrix metallopeptidase 2 Homo sapiens 48-53 15851572-4 2005 RESULTS: PGF(2alpha) increased the secretion of MMP-2 in a dose-dependent manner with an EC(50) of 2.7 x 10(-8) M. The addition of 1 muM PGF(2alpha) also increased MMP-2 secretion in a time-dependent manner with maximum secretion occurring at 4 hours after administration. Prostaglandins F 9-12 matrix metallopeptidase 2 Homo sapiens 164-169 15851572-4 2005 RESULTS: PGF(2alpha) increased the secretion of MMP-2 in a dose-dependent manner with an EC(50) of 2.7 x 10(-8) M. The addition of 1 muM PGF(2alpha) also increased MMP-2 secretion in a time-dependent manner with maximum secretion occurring at 4 hours after administration. Prostaglandins F 137-140 matrix metallopeptidase 2 Homo sapiens 48-53 15851572-4 2005 RESULTS: PGF(2alpha) increased the secretion of MMP-2 in a dose-dependent manner with an EC(50) of 2.7 x 10(-8) M. The addition of 1 muM PGF(2alpha) also increased MMP-2 secretion in a time-dependent manner with maximum secretion occurring at 4 hours after administration. Prostaglandins F 137-140 matrix metallopeptidase 2 Homo sapiens 164-169 15851572-6 2005 The secretory action of PGF(2alpha) was inhibited by pretreatment with a protein kinase C (PKC) inhibitor, chelerythrine chloride; the FP receptor antagonist, AL-8810; and the MEK inhibitor, PD-98059. Prostaglandins F 24-27 mitogen-activated protein kinase kinase 7 Homo sapiens 176-179 15851572-7 2005 The addition of PGF(2alpha) and latanoprost acid increased ERK1/2 activity by 117% +/- 12% and 75% +/- 9%, respectively. Prostaglandins F 16-19 mitogen-activated protein kinase 3 Homo sapiens 59-65 15851572-8 2005 The PGF(2alpha)- and latanoprost-acid-induced ERK1/2 activation was blocked by the presence of PKC inhibitors and downregulation of PKC by prolonged incubation with a phorbol ester. Prostaglandins F 4-7 mitogen-activated protein kinase 3 Homo sapiens 46-52 15601909-7 2005 In conclusion, the evidence indicates that PKCepsilon, an isozyme expressed in corpora lutea with acquired PGF(2alpha) luteolytic capacity, has a regulatory role in the PGF(2alpha)-induced Ca(2+) signaling in luteal steroidogenic cells, and that this in turn may have consequences (at least in part) on the ability of PGF(2alpha) to inhibit LH-stimulated P(4) synthesis at this developmental stage. Prostaglandins F 169-172 protein kinase C epsilon Bos taurus 43-53 15601909-7 2005 In conclusion, the evidence indicates that PKCepsilon, an isozyme expressed in corpora lutea with acquired PGF(2alpha) luteolytic capacity, has a regulatory role in the PGF(2alpha)-induced Ca(2+) signaling in luteal steroidogenic cells, and that this in turn may have consequences (at least in part) on the ability of PGF(2alpha) to inhibit LH-stimulated P(4) synthesis at this developmental stage. Prostaglandins F 169-172 protein kinase C epsilon Bos taurus 43-53 15601920-4 2005 Thus, the relative expression of FP and EP1-4 may determine the responsiveness to PGE(2) and PGF(2alpha). Prostaglandins F 93-96 prostaglandin E2 receptor EP2 subtype Ovis aries 40-45 16181102-10 2005 HO-1 gene transduction prevented glucose-mediated elevation of 8-epi-isoprostane PGF(2alpha). Prostaglandins F 81-84 heme oxygenase 1 Homo sapiens 0-4 15601909-4 2005 A PKCepsilon inhibitor reduced the PGF(2alpha)-elicited calcium responses in both Day 10 LLCs and SLCs to 3.5 +/- 0.3 (n = 217) and 1.3 +/- 0.1 (n = 205), respectively. Prostaglandins F 35-38 protein kinase C epsilon Bos taurus 2-12 15601909-6 2005 Both conventional and PKCepsilon-specific inhibitors reversed the ability of PGF(2alpha) to decrease LH-stimulated P(4) accumulation, and the PKCepsilon inhibitor was more effective at this than the conventional PKC inhibitor. Prostaglandins F 77-80 protein kinase C epsilon Bos taurus 22-32 15776109-6 2005 PGF(2alpha) at 8% WT levels was sufficient to induce coordinated temporal oxytocin receptor (OTR) expression in uterus and normal ovarian luteolysis in PGHS1(Neo/Neo) mice at late gestation, while absence of PGHS1 expression in null mice delayed OTR induction and the programmed decrease of serum progesterone during parturition. Prostaglandins F 0-3 oxytocin receptor Mus musculus 74-91 15776109-6 2005 PGF(2alpha) at 8% WT levels was sufficient to induce coordinated temporal oxytocin receptor (OTR) expression in uterus and normal ovarian luteolysis in PGHS1(Neo/Neo) mice at late gestation, while absence of PGHS1 expression in null mice delayed OTR induction and the programmed decrease of serum progesterone during parturition. Prostaglandins F 0-3 oxytocin receptor Mus musculus 93-96 15776109-6 2005 PGF(2alpha) at 8% WT levels was sufficient to induce coordinated temporal oxytocin receptor (OTR) expression in uterus and normal ovarian luteolysis in PGHS1(Neo/Neo) mice at late gestation, while absence of PGHS1 expression in null mice delayed OTR induction and the programmed decrease of serum progesterone during parturition. Prostaglandins F 0-3 prostaglandin-endoperoxide synthase 1 Mus musculus 152-157 15776109-6 2005 PGF(2alpha) at 8% WT levels was sufficient to induce coordinated temporal oxytocin receptor (OTR) expression in uterus and normal ovarian luteolysis in PGHS1(Neo/Neo) mice at late gestation, while absence of PGHS1 expression in null mice delayed OTR induction and the programmed decrease of serum progesterone during parturition. Prostaglandins F 0-3 prostaglandin-endoperoxide synthase 1 Mus musculus 208-213 15776109-6 2005 PGF(2alpha) at 8% WT levels was sufficient to induce coordinated temporal oxytocin receptor (OTR) expression in uterus and normal ovarian luteolysis in PGHS1(Neo/Neo) mice at late gestation, while absence of PGHS1 expression in null mice delayed OTR induction and the programmed decrease of serum progesterone during parturition. Prostaglandins F 0-3 oxytocin receptor Mus musculus 246-249 15654655-1 2005 We have previously reported that prostaglandin F(2alpha) (PGF(2alpha)) and its selective agonist fluprostenol increase basic fibroblast growth factor (FGF-2) mRNA and protein production in osteoblastic Py1a cells. Prostaglandins F 33-48 fibroblast growth factor 2 Homo sapiens 151-156 15539607-7 2005 The levels of PGE(2) and PGF(2alpha) in the cerebrospinal fluid (CSF) of pentobarbital sodium-anesthetized rats were significantly increased 3 h after the injection of LPS or ET-1. Prostaglandins F 25-28 endothelin 1 Rattus norvegicus 175-179 15654655-9 2005 In addition, cells treated with PGF(2alpha) exhibit increased nuclear labelling for the mitogen-activated protein kinase (MAPK), p44/ERK2. Prostaglandins F 32-35 mitogen-activated protein kinase 1 Homo sapiens 133-137 15701619-12 2005 In response to low doses of agonists or during maintenance of tone, presumably due to low levels of calcium release, a PKC-dependent pathway is activated, whereas at high doses of PGF(2alpha) and thromboxane analogs, in the initial phase of contraction, calmodulin is activated, PKC activity is reduced, and contraction is mediated, in part, through a Ca(2+)-calmodulin-MLCK-dependent pathway. Prostaglandins F 180-183 protein kinase C epsilon Homo sapiens 119-122 15701619-13 2005 The PKC-dependent signaling pathways activated by PGF(2alpha) and by thromboxanes during sustained LES contraction, however, remain to be examined, but preliminary data indicate that a distinct PKC-dependent pathway may be activated during maintenance of tonic contraction, which is different from the one activated during the initial contractile response. Prostaglandins F 50-53 protein kinase C epsilon Homo sapiens 4-7 15701619-13 2005 The PKC-dependent signaling pathways activated by PGF(2alpha) and by thromboxanes during sustained LES contraction, however, remain to be examined, but preliminary data indicate that a distinct PKC-dependent pathway may be activated during maintenance of tonic contraction, which is different from the one activated during the initial contractile response. Prostaglandins F 50-53 protein kinase C epsilon Homo sapiens 194-197 15701619-15 2005 Sustained contraction in response to PGF(2alpha) may involve activation of the monomeric G protein RhoA, because the contraction is inhibited by the RhoA-kinase antagonist Y27632. Prostaglandins F 37-40 ras homolog family member A Homo sapiens 99-103 15701619-15 2005 Sustained contraction in response to PGF(2alpha) may involve activation of the monomeric G protein RhoA, because the contraction is inhibited by the RhoA-kinase antagonist Y27632. Prostaglandins F 37-40 ras homolog family member A Homo sapiens 149-153 15654655-11 2005 We conclude that PGF(2alpha) stimulates nuclear translocation of FGF-2 and FGFR2 by a PKC-dependent pathway; we also suggest an involvement of MAPK/ERK2 in this process. Prostaglandins F 17-20 fibroblast growth factor 2 Homo sapiens 65-70 15654655-1 2005 We have previously reported that prostaglandin F(2alpha) (PGF(2alpha)) and its selective agonist fluprostenol increase basic fibroblast growth factor (FGF-2) mRNA and protein production in osteoblastic Py1a cells. Prostaglandins F 58-61 fibroblast growth factor 2 Homo sapiens 151-156 15654655-11 2005 We conclude that PGF(2alpha) stimulates nuclear translocation of FGF-2 and FGFR2 by a PKC-dependent pathway; we also suggest an involvement of MAPK/ERK2 in this process. Prostaglandins F 17-20 fibroblast growth factor receptor 2 Homo sapiens 75-80 15654655-2 2005 The present report extends our previous studies by showing that Py1a cells express FGF receptor-2 (FGFR2) and that treatment with PGF(2alpha) or fluprostenol decreases FGFR2 mRNA. Prostaglandins F 130-133 fibroblast growth factor receptor 2 Homo sapiens 83-97 15654655-11 2005 We conclude that PGF(2alpha) stimulates nuclear translocation of FGF-2 and FGFR2 by a PKC-dependent pathway; we also suggest an involvement of MAPK/ERK2 in this process. Prostaglandins F 17-20 mitogen-activated protein kinase 1 Homo sapiens 148-152 15654655-2 2005 The present report extends our previous studies by showing that Py1a cells express FGF receptor-2 (FGFR2) and that treatment with PGF(2alpha) or fluprostenol decreases FGFR2 mRNA. Prostaglandins F 130-133 fibroblast growth factor receptor 2 Homo sapiens 99-104 15654655-2 2005 The present report extends our previous studies by showing that Py1a cells express FGF receptor-2 (FGFR2) and that treatment with PGF(2alpha) or fluprostenol decreases FGFR2 mRNA. Prostaglandins F 130-133 fibroblast growth factor receptor 2 Homo sapiens 168-173 15654655-3 2005 We have used confocal and electron microscopy to show that, under PGF(2alpha) stimulation, FGF-2 and FGFR2 proteins accumulate near the nuclear envelope and colocalize in the nucleus of Py1a cells. Prostaglandins F 66-69 fibroblast growth factor 2 Homo sapiens 91-96 15654655-3 2005 We have used confocal and electron microscopy to show that, under PGF(2alpha) stimulation, FGF-2 and FGFR2 proteins accumulate near the nuclear envelope and colocalize in the nucleus of Py1a cells. Prostaglandins F 66-69 fibroblast growth factor receptor 2 Homo sapiens 101-106 15654655-4 2005 Pre-treatment with cycloheximide blocks nuclear labelling for FGF-2 in response to PGF(2alpha). Prostaglandins F 83-86 fibroblast growth factor 2 Homo sapiens 62-67 15654655-7 2005 In particular, pre-treatment with phorbol 12-myristate 13-acetate (PMA) prevents the nuclear accumulation of FGF-2 and FGFR2 in response to PGF(2alpha). Prostaglandins F 140-143 fibroblast growth factor 2 Homo sapiens 109-114 15654655-7 2005 In particular, pre-treatment with phorbol 12-myristate 13-acetate (PMA) prevents the nuclear accumulation of FGF-2 and FGFR2 in response to PGF(2alpha). Prostaglandins F 140-143 fibroblast growth factor receptor 2 Homo sapiens 119-124 15654655-9 2005 In addition, cells treated with PGF(2alpha) exhibit increased nuclear labelling for the mitogen-activated protein kinase (MAPK), p44/ERK2. Prostaglandins F 32-35 interferon induced protein 44 Homo sapiens 129-132 16244494-5 2005 The addition of antiserum against IGF-I decreased IGF-I output, increased P, OT, IGFBP-3, and PGF secretion, and had no effect on E release. Prostaglandins F 94-97 insulin like growth factor 1 Homo sapiens 34-39 16244494-6 2005 Immunoneutralization of IGF-I also prevented or reversed the effects of leptin on P, E, IGF-I, IGFBP-3, PGF, but not on OT. Prostaglandins F 104-107 insulin like growth factor 1 Homo sapiens 24-29 15087429-9 2004 Prostaglandin E(2), which signals through cAMP, increased E4bp4 mRNA at all doses, whereas prostaglandin F(2alpha) that primarily activates PKC and calcium signaling, induced E4bp4 only at high doses and fluprostenol that only activates PKC and calcium signaling, had no effect. Prostaglandins F 91-106 nuclear factor, interleukin 3, regulated Mus musculus 175-180 15454176-8 2004 Furthermore, the knowledge of an association between the presence of P-selectin-positive platelet aggregates and PGF criteria might have implications for graft management and therapeutic strategies. Prostaglandins F 113-116 selectin P Homo sapiens 69-79 15459842-1 2004 BACKGROUND: Histological changes of, in particular, collagen and extracellular matrix after administration of topical prostaglandin F(2alpha)(PGF (2alpha)) analogues have been reported. Prostaglandins F 118-133 placental growth factor Homo sapiens 142-145 15591146-4 2005 In CL cultured in vitro, ET-1 increased (P </= 0.01) both PGF(2alpha) production and luteal nitric oxide synthase activity but decreased (P < or = 0.01) progesterone release. Prostaglandins F 61-64 endothelin-1 Oryctolagus cuniculus 25-29 15557445-8 2004 RESULTS: Real-time PCR results showed that 24 hours of exposure to 100 nM PGF(2alpha) significantly increased mRNA for MMP-1 and -9 (P < 0.06 Wilcoxon test) and that exposure to 100 nM latanoprost acid significantly increased mRNA for MMP-9 (P < 0.06 Wilcoxon test). Prostaglandins F 74-77 matrix metallopeptidase 1 Homo sapiens 119-131 15557445-8 2004 RESULTS: Real-time PCR results showed that 24 hours of exposure to 100 nM PGF(2alpha) significantly increased mRNA for MMP-1 and -9 (P < 0.06 Wilcoxon test) and that exposure to 100 nM latanoprost acid significantly increased mRNA for MMP-9 (P < 0.06 Wilcoxon test). Prostaglandins F 74-77 matrix metallopeptidase 9 Homo sapiens 238-243 15253926-9 2004 Stimulation with IL-1alpha and IL-1beta decreased the PGE(2):PGF(2alpha) ratio in the developing stage (P < 0.05), whereas it increased the ratio in the mid stage (P < 0.05). Prostaglandins F 61-64 interleukin 1 alpha Bos taurus 17-26 15253926-9 2004 Stimulation with IL-1alpha and IL-1beta decreased the PGE(2):PGF(2alpha) ratio in the developing stage (P < 0.05), whereas it increased the ratio in the mid stage (P < 0.05). Prostaglandins F 61-64 interleukin 1 beta Bos taurus 31-39 15253926-11 2004 Overall results indicate that genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in the bovine CL throughout the luteal phase, and suggest that IL-1alpha and IL-1beta have different roles as local modulators to regulate PGF(2alpha) and PGE(2) production during the luteal phase. Prostaglandins F 250-253 interleukin 1 alpha Bos taurus 40-49 15253926-11 2004 Overall results indicate that genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in the bovine CL throughout the luteal phase, and suggest that IL-1alpha and IL-1beta have different roles as local modulators to regulate PGF(2alpha) and PGE(2) production during the luteal phase. Prostaglandins F 250-253 interleukin 1 beta Bos taurus 54-62 15253926-11 2004 Overall results indicate that genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in the bovine CL throughout the luteal phase, and suggest that IL-1alpha and IL-1beta have different roles as local modulators to regulate PGF(2alpha) and PGE(2) production during the luteal phase. Prostaglandins F 250-253 interleukin 1 alpha Bos taurus 174-183 15253926-11 2004 Overall results indicate that genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in the bovine CL throughout the luteal phase, and suggest that IL-1alpha and IL-1beta have different roles as local modulators to regulate PGF(2alpha) and PGE(2) production during the luteal phase. Prostaglandins F 250-253 interleukin 1 beta Bos taurus 188-196 15269098-2 2004 There is now clear evidence that the vasoactive peptides endothelin-1 (ET-1) and angiotensin II (Ang II) interact with PGF(2alpha) in the luteolytic cascade during PGF(2alpha)-induced luteolysis in the cow. Prostaglandins F 119-122 endothelin 1 Bos taurus 57-69 15269098-2 2004 There is now clear evidence that the vasoactive peptides endothelin-1 (ET-1) and angiotensin II (Ang II) interact with PGF(2alpha) in the luteolytic cascade during PGF(2alpha)-induced luteolysis in the cow. Prostaglandins F 119-122 endothelin 1 Bos taurus 71-75 15269098-2 2004 There is now clear evidence that the vasoactive peptides endothelin-1 (ET-1) and angiotensin II (Ang II) interact with PGF(2alpha) in the luteolytic cascade during PGF(2alpha)-induced luteolysis in the cow. Prostaglandins F 164-167 endothelin 1 Bos taurus 57-69 15269098-2 2004 There is now clear evidence that the vasoactive peptides endothelin-1 (ET-1) and angiotensin II (Ang II) interact with PGF(2alpha) in the luteolytic cascade during PGF(2alpha)-induced luteolysis in the cow. Prostaglandins F 164-167 endothelin 1 Bos taurus 71-75 15269098-7 2004 The intraluteal PGF(2alpha) secretion slightly increased from 12 h after the onset of luteolysis (0 h) and drastically increased (by about 300%) from 24 h. Intraluteal ET-1 secretion increased from 12 h. Intraluteal Ang II secretion was elevated from 0 h and was maintained at high levels (about 180%) toward estrus. Prostaglandins F 16-19 endothelin 1 Bos taurus 168-172 15269098-10 2004 In conclusion, we propose that the increase of PGF(2alpha), ET-1, and Ang II within the CL during luteolysis is a common phenomenon for both PGF(2alpha)-induced and spontaneous luteolysis. Prostaglandins F 141-144 endothelin 1 Bos taurus 60-64 15271885-8 2004 PGF(2alpha) decreased luteal P450arom mRNA and protein levels in vivo and in vitro. Prostaglandins F 0-3 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 29-37 15271885-10 2004 The time course of the decrease in P450arom mRNA by PGF(2alpha) reflected the P450arom mRNA half-life determined by actinomycin D. Prostaglandins F 52-55 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 35-43 15271885-10 2004 The time course of the decrease in P450arom mRNA by PGF(2alpha) reflected the P450arom mRNA half-life determined by actinomycin D. Prostaglandins F 52-55 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 78-86 15271885-11 2004 Moreover, nuclear run-on assay showed that PGF(2alpha) attenuates P450arom gene transcription. Prostaglandins F 43-46 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 66-74 15271885-12 2004 Gel shift assays revealed that GATA-4 binds to the P450aromatase promoter, and that such binding is increased by PGF(2alpha). Prostaglandins F 113-116 GATA binding protein 4 Mus musculus 31-37 15271885-12 2004 Gel shift assays revealed that GATA-4 binds to the P450aromatase promoter, and that such binding is increased by PGF(2alpha). Prostaglandins F 113-116 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 51-64 15271885-13 2004 It is concluded that PGF(2alpha) decreases luteal P450arom mRNA levels at the end of pregnancy in rodents by inhibiting cyp19 expression. Prostaglandins F 21-24 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 50-58 15271885-13 2004 It is concluded that PGF(2alpha) decreases luteal P450arom mRNA levels at the end of pregnancy in rodents by inhibiting cyp19 expression. Prostaglandins F 21-24 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 120-125 15308607-6 2004 IFNtau influences cell-specific expression of COX-2, PGFS, EP2, and EP3 in endometrium, myometrium, and CL in a spatio-temporal and tissue-specific manner, whereas it does not alter COX-1, PGES, PG 15-dehydrogenase, PG transporter, or PGF(2alpha) receptor expression in any of these tissues. Prostaglandins F 53-57 interferon tau-2 Bos taurus 0-6 15308607-7 2004 In endometrium, IFNtau decreases PGFS in epithelial cells and increases EP2 in stroma. Prostaglandins F 33-37 interferon tau-2 Bos taurus 16-22 15308607-8 2004 In myometrium, IFNtau decreases PGFS and increases EP2 in smooth muscle cells. Prostaglandins F 32-36 interferon tau-2 Bos taurus 15-21 15336698-7 2004 PGF(2alpha), metabolism was assessed by PGDH activity, which resulted high during pregnancy and increased as a result of P(4) administration. Prostaglandins F 0-3 15-hydroxyprostaglandin dehydrogenase Rattus norvegicus 40-44 14985247-8 2004 Both the p38 MAPK inhibitor and IFN-tau decreased prostaglandin F(2alpha) secretion, and decreases were additive when the two were given together. Prostaglandins F 50-65 mitogen-activated protein kinase 14 Bos taurus 9-12 14985247-8 2004 Both the p38 MAPK inhibitor and IFN-tau decreased prostaglandin F(2alpha) secretion, and decreases were additive when the two were given together. Prostaglandins F 50-65 interferon-tau-like Bos taurus 32-39 14985247-9 2004 In summary, activation of p38 MAPK by PdBu is required for continued presence of PGHS-2 mRNA and secretion of prostaglandin F(2alpha) in BEND cells. Prostaglandins F 110-125 mitogen-activated protein kinase 14 Bos taurus 26-29 15012601-2 2004 We hypothesized that the enzymes downstream of PG endoperoxide synthase-2 (PGHS-2) determine the ratio of PGF(2 alpha) and PGE(2) in the utero-ovarian vein plasma and the time of normal and preterm labour onset. Prostaglandins F 106-109 prostaglandin G/H synthase 2 Ovis aries 47-73 15140225-3 2004 In this report, we show that activation of keratinocyte PAR-2 stimulates release of PGE(2) and PGF(2alpha) and that PGE(2) and PGF(2alpha) act as paracrine factors that stimulate melanocyte dendricity. Prostaglandins F 95-98 F2R like trypsin receptor 1 Homo sapiens 56-61 15140225-9 2004 Our data suggest that PAR-2 mediates cutaneous pigmentation both through increased uptake of melanosomes by keratinocytes, as well as by release of PGE(2) and PGF(2alpha) that stimulate melanocyte dendricity through EP1, EP3, and FP receptors. Prostaglandins F 159-162 F2R like trypsin receptor 1 Homo sapiens 22-27 15059644-5 2004 In addition, a nonselective (acetylsalicylic acid) or selective cyclooxygenase (COX) 1 inhibitor (SC-560) completely abrogated the 8-iso-PGF(2alpha) and PGF(2alpha) formation in kidneys subjected to ischemia. Prostaglandins F 137-140 cytochrome c oxidase I, mitochondrial Rattus norvegicus 64-86 15113997-1 2004 OBJECTIVE: To investigate the effects of the cyclooxygenase-2 (cox-2)-dependent prostaglandins D(2) (PGD(2)), E(2) (PGE(2)) and F(2)alpha (PGF(2)alpha) on the redifferentiation and cartilage matrix production of dedifferentiated articular chondrocytes. Prostaglandins F 139-142 prostaglandin-endoperoxide synthase 2 Homo sapiens 45-61 15113997-1 2004 OBJECTIVE: To investigate the effects of the cyclooxygenase-2 (cox-2)-dependent prostaglandins D(2) (PGD(2)), E(2) (PGE(2)) and F(2)alpha (PGF(2)alpha) on the redifferentiation and cartilage matrix production of dedifferentiated articular chondrocytes. Prostaglandins F 139-142 mitochondrially encoded cytochrome c oxidase II Homo sapiens 63-68 15159280-0 2004 Upregulation of orphan nuclear receptor Nur77 following PGF(2alpha), Bimatoprost, and Butaprost treatments. Prostaglandins F 56-59 nuclear receptor subfamily 4 group A member 1 Homo sapiens 40-45 15159280-3 2004 Using gene chip technology, we first identified that PGF(2alpha) (FP agonist) and Butaprost (EP(2) agonist) induced about a five-fold upregulation of Nur77 mRNA expression in hFP-HEK 293/EBNA and hEP(2)-HEK293/EBNA cells. Prostaglandins F 53-56 nuclear receptor subfamily 4 group A member 1 Homo sapiens 150-155 15159280-4 2004 Northern Blot analysis revealed that PGF(2alpha)- and Butaprost-induced upregulation of Nur77 expression are dose- and time-dependent. Prostaglandins F 37-40 nuclear receptor subfamily 4 group A member 1 Homo sapiens 88-93 15159280-6 2004 Both PGF(2alpha) and Butaprost upregulated Nur77 gene expression through the protein kinase C (PKC) pathway. Prostaglandins F 5-8 nuclear receptor subfamily 4 group A member 1 Homo sapiens 43-48 15159280-8 2004 Calcineurin was found to be involved downstream of the PKC pathway in PGF(2alpha)-induced Nur77 expression, but not in Butaprost-induced Nur77 expression. Prostaglandins F 70-73 nuclear receptor subfamily 4 group A member 1 Homo sapiens 90-95 15159280-10 2004 We also used Nur77 as a marker gene to compare the effects of PGF(2alpha), Butaprost, and Bimatoprost (a prostamide) on Nur77 expression in human primary trabecular meshwork and ciliary smooth muscle (SM) cells, which are target cells for antiglaucoma drugs. Prostaglandins F 62-65 nuclear receptor subfamily 4 group A member 1 Homo sapiens 120-125 15159280-11 2004 The results showed that PGF(2alpha) and Butaprost, but not Bimatoprost, induced upregulation of Nur77 expression in human TM cells. Prostaglandins F 24-27 nuclear receptor subfamily 4 group A member 1 Homo sapiens 96-101 15159280-12 2004 PGF(2alpha), but not Bimatoprost, dramatically induced upregulation of Nur77 mRNA expression in human ciliary SM cells, whereas Butaprost slightly upregulated Nur77 mRNA expression in SM cells. Prostaglandins F 0-3 nuclear receptor subfamily 4 group A member 1 Homo sapiens 71-76 15159280-14 2004 Nur77 promoter deletion analysis indicated that PGF(2alpha), but not Bimatoprost, activated Nur77 promoter-luciferase reporter in hFP-HEK 293/EBNA cells. Prostaglandins F 48-51 nuclear receptor subfamily 4 group A member 1 Homo sapiens 0-5 15159280-14 2004 Nur77 promoter deletion analysis indicated that PGF(2alpha), but not Bimatoprost, activated Nur77 promoter-luciferase reporter in hFP-HEK 293/EBNA cells. Prostaglandins F 48-51 nuclear receptor subfamily 4 group A member 1 Homo sapiens 92-97 15159280-18 2004 It appears that PGF(2alpha) and Butaprost activate Nur77 transcription mechanisms through the activation of FP and EP(2) receptor-coupled signaling pathways, whereas Bimatoprost stimulates neither FP nor EP(2) receptors. Prostaglandins F 16-19 nuclear receptor subfamily 4 group A member 1 Homo sapiens 51-56 15226598-4 2004 Moreover, we investigated the intracellular mechanisms of TNFalpha- and NO-regulated prostaglandin (PG) F(2alpha) and PGE(2) synthesis. Prostaglandins F 85-105 tumor necrosis factor Bos taurus 58-66 15016822-8 2004 Other prostaglandins (thromboxane B2, PGD2, PGF(2alpha), and 6-keto-PGF(1alpha)) were significantly elevated in stomachs of mPGES-1-null mice but not in other tissues. Prostaglandins F 44-47 prostaglandin E synthase Mus musculus 124-131 15012601-2 2004 We hypothesized that the enzymes downstream of PG endoperoxide synthase-2 (PGHS-2) determine the ratio of PGF(2 alpha) and PGE(2) in the utero-ovarian vein plasma and the time of normal and preterm labour onset. Prostaglandins F 106-109 prostaglandin G/H synthase 2 Ovis aries 75-81 15012601-3 2004 The aim of this study was to simultaneously determine the expression of PGF and PGE synthases (PGFS and PGES) in gestational tissues at spontaneous and induced-preterm labour in sheep. Prostaglandins F 72-75 prostaglandin F synthase 1 Ovis aries 95-99 14993728-2 2004 In BALB/c mice chronically administrated with a neutralizing anti-c-Kit monoclonal antibody (ACK2), rhythmic contraction of the gastrointestinal tract was impaired and contractile responses to drugs, including acetylcholine, prostaglandin F(2alpha), and bradykinin, were anomalously augmented. Prostaglandins F 225-240 KIT proto-oncogene receptor tyrosine kinase Mus musculus 66-71 14764825-1 2004 Prostaglandin F(2 alpha)(PGF(2 alpha)) is a bioactive lipid biosynthesized by cyclooxygenase (COX) enzymes and mediates its biological activity via the heptahelical G(q)-coupled PGF(2 alpha)receptor (FP receptor). Prostaglandins F 0-16 prostaglandin F receptor Homo sapiens 178-198 14522831-11 2004 Translocation of PKC from cytoplasm to membrane fraction was used as indication of PKC activation by PGF(2alpha). Prostaglandins F 101-104 protein kinase C epsilon Bos taurus 17-20 14522831-11 2004 Translocation of PKC from cytoplasm to membrane fraction was used as indication of PKC activation by PGF(2alpha). Prostaglandins F 101-104 protein kinase C epsilon Bos taurus 83-86 14522831-12 2004 Evidence for PKC activation was observed in both Day-4 and Day-10 luteal samples treated with 10 nM PGF(2alpha). Prostaglandins F 100-103 protein kinase C epsilon Bos taurus 13-16 14561653-12 2004 Furthermore, the presence of the conceptus was shown to block the induction of COX-2 expression at Day 15, suggesting an important mechanism by which it may suppress uterine PGF(2alpha) release and prevent luteolysis during early pregnancy. Prostaglandins F 174-177 prostaglandin-endoperoxide synthase 2 Equus caballus 79-84 14561657-8 2004 LH-R and p450scc mRNA were down-regulated (P < 0.05) during structural luteolysis (after 12 h), and p450scc in addition at 2 h after PGF(2alpha) (P < 0.05). Prostaglandins F 136-139 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 103-110 14561657-9 2004 FGF-2 expression increased (P < 0.001) during functional luteolysis (until 12 h after PGF(2alpha)) and diminished thereafter. Prostaglandins F 89-92 fibroblast growth factor 2 Bos taurus 0-5 14764825-1 2004 Prostaglandin F(2 alpha)(PGF(2 alpha)) is a bioactive lipid biosynthesized by cyclooxygenase (COX) enzymes and mediates its biological activity via the heptahelical G(q)-coupled PGF(2 alpha)receptor (FP receptor). Prostaglandins F 25-28 prostaglandin F receptor Homo sapiens 178-198 14764825-7 2004 We investigated whether PGF(2 alpha) could trans-activate the epidermal growth factor receptor (EGFR) and trigger the MAPK signaling pathway. Prostaglandins F 24-27 epidermal growth factor receptor Homo sapiens 62-94 14764825-7 2004 We investigated whether PGF(2 alpha) could trans-activate the epidermal growth factor receptor (EGFR) and trigger the MAPK signaling pathway. Prostaglandins F 24-27 epidermal growth factor receptor Homo sapiens 96-100 14764825-8 2004 Treatment of adenocarcinoma explants and endometrial adenocarcinoma cells (Ishikawa) with PGF(2 alpha)-phosphorylated EGFR, triggered MAPK signaling and enhanced the proliferation of Ishikawa cells. Prostaglandins F 90-93 epidermal growth factor receptor Homo sapiens 118-122 14764825-9 2004 Inactivation of phospholipase C, EGFR kinase, and MAPK kinase with specific inhibitors abolished PGF(2 alpha)-induced trans-activation of EGFR, MAPK signaling, and Ishikawa cell proliferation. Prostaglandins F 97-100 epidermal growth factor receptor Homo sapiens 33-37 14764825-9 2004 Inactivation of phospholipase C, EGFR kinase, and MAPK kinase with specific inhibitors abolished PGF(2 alpha)-induced trans-activation of EGFR, MAPK signaling, and Ishikawa cell proliferation. Prostaglandins F 97-100 epidermal growth factor receptor Homo sapiens 138-142 14967905-5 2003 In primary culture of frozen and unfrozen endometrial cells, OT strongly stimulated PGF(2alpha) production in epithelial cells, and TNFalpha strongly stimulated PGF(2alpha) production in stromal cells (P<0.05). Prostaglandins F 161-164 tumor necrosis factor Bos taurus 132-140 15067210-5 2004 RESULTS: The present work shows that iNOS inhibitor, aminoguanidine, reduced NO and PGE(2)/PGF(2alpha) production induced by LPS injection. Prostaglandins F 91-94 nitric oxide synthase 2 Rattus norvegicus 37-41 14643177-5 2004 The intra-uterine administration of EGF 500 ng in day 21 of pregnancy induced increases in PGE(2) (P<0.001) and PGF(2alpha) (P<0.01) compared to the control fetal membranes from pregnant rats on day 22. Prostaglandins F 115-118 epidermal growth factor like 1 Rattus norvegicus 36-39 15056776-0 2004 Local interaction of prostaglandin F 2alpha with endothelin-1 and tumor necrosis factor-alpha on the release of progesterone and oxytocin in ovine corpora lutea in vivo: a possible implication for a luteolytic cascade. Prostaglandins F 21-36 endothelin 1 Homo sapiens 49-93 15056776-2 2004 Thus, in the present study the interactions of ET-1 and TNFalpha with prostaglandin F(2alpha) (PGF(2alpha)) on the release of progesterone and oxytocin (OT) within the corpus luteum (CL) were investigated. Prostaglandins F 95-98 endothelin 1 Homo sapiens 47-51 15056776-5 2004 A perfusion of PGF(2alpha) (1 micromol l (-1)) increased ET-1 release over a period of 12 h. Two perfusions of ET-1 (0.1 micromol l(-1)) or a perfusion of ET-1 followed by TNFalpha (200 ng ml(-1)) decreased progesterone release (56-64% at 36-48 h). Prostaglandins F 15-18 endothelin 1 Homo sapiens 57-61 15056776-5 2004 A perfusion of PGF(2alpha) (1 micromol l (-1)) increased ET-1 release over a period of 12 h. Two perfusions of ET-1 (0.1 micromol l(-1)) or a perfusion of ET-1 followed by TNFalpha (200 ng ml(-1)) decreased progesterone release (56-64% at 36-48 h). Prostaglandins F 15-18 tumor necrosis factor Homo sapiens 172-180 15056776-6 2004 When the CL were pre-perfused with PGF(2alpha) (1 micromol l(-1)), two consecutive perfusions of ET-1 decreased progesterone release more rapidly. Prostaglandins F 35-38 endothelin 1 Homo sapiens 97-101 15056776-7 2004 Similarly, a pre-perfusion with PGF(2alpha) followed by consecutive perfusions of ET-1 and then TNFalpha rapidly decreased progesterone release, with the inhibition most pronounced (35%) at 36-48 h. The simultaneous infusion of ET-1 with PGF(2alpha) induced a rapid decrease in progesterone release (36% at 36-48 h). Prostaglandins F 32-35 endothelin 1 Homo sapiens 228-232 15056776-7 2004 Similarly, a pre-perfusion with PGF(2alpha) followed by consecutive perfusions of ET-1 and then TNFalpha rapidly decreased progesterone release, with the inhibition most pronounced (35%) at 36-48 h. The simultaneous infusion of ET-1 with PGF(2alpha) induced a rapid decrease in progesterone release (36% at 36-48 h). Prostaglandins F 238-241 endothelin 1 Homo sapiens 82-86 15056776-7 2004 Similarly, a pre-perfusion with PGF(2alpha) followed by consecutive perfusions of ET-1 and then TNFalpha rapidly decreased progesterone release, with the inhibition most pronounced (35%) at 36-48 h. The simultaneous infusion of ET-1 with PGF(2alpha) induced a rapid decrease in progesterone release (36% at 36-48 h). Prostaglandins F 238-241 tumor necrosis factor Homo sapiens 96-104 15056776-8 2004 In a further study, the possible second messenger systems involved in PGF(2alpha) action on the release of progesterone, OT and ET-1 were investigated. Prostaglandins F 70-73 endothelin 1 Homo sapiens 128-132 15056776-11 2004 These results show that ET-1 is capable of suppressing progesterone release in the PGF(2alpha)-primed ovine CL in vivo and thus ET-1 works as a local luteolysin together with PGF(2alpha) during the process of functional luteolysis. Prostaglandins F 83-86 endothelin 1 Homo sapiens 24-28 15056776-11 2004 These results show that ET-1 is capable of suppressing progesterone release in the PGF(2alpha)-primed ovine CL in vivo and thus ET-1 works as a local luteolysin together with PGF(2alpha) during the process of functional luteolysis. Prostaglandins F 175-178 endothelin 1 Homo sapiens 24-28 15056776-11 2004 These results show that ET-1 is capable of suppressing progesterone release in the PGF(2alpha)-primed ovine CL in vivo and thus ET-1 works as a local luteolysin together with PGF(2alpha) during the process of functional luteolysis. Prostaglandins F 175-178 endothelin 1 Homo sapiens 128-132 15056776-12 2004 During structural luteolysis, TNFalpha may interact with PGF(2alpha) and ET-1 to cause a rapid drop in progesterone release and accelerate the process of luteolysis. Prostaglandins F 57-60 tumor necrosis factor Homo sapiens 30-38 15056776-13 2004 This result supports the contention that ET-1 and TNFalpha interact with PGF(2alpha) as local luteolytic mediators in the ewe as previously suggested. Prostaglandins F 73-76 endothelin 1 Homo sapiens 41-45 14613532-5 2003 Prostaglandin F-2alpha (PGF-2alpha) has been shown to be a primary endogenous hormone responsible for triggering luteal secretion of oxytocin. Prostaglandins F 24-27 oxytocin/neurophysin I prepropeptide Homo sapiens 133-141 14613532-6 2003 Details are provided regarding the PGF-2alpha-induced intracellular signal transduction pathway that ultimately results in exocytosis of luteal oxytocin. Prostaglandins F 35-38 oxytocin/neurophysin I prepropeptide Homo sapiens 144-152 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Prostaglandins F 9-12 interleukin 1 beta Rattus norvegicus 151-159 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Prostaglandins F 93-96 interleukin 1 beta Rattus norvegicus 25-42 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Prostaglandins F 93-96 interleukin 1 beta Rattus norvegicus 25-42 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Prostaglandins F 93-96 interleukin 1 beta Rattus norvegicus 44-52 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Prostaglandins F 93-96 interleukin 1 beta Rattus norvegicus 44-52 14611637-6 2003 In contrast, IL-1beta enhanced PGF(2alpha) concentrations at 8 h only at the higher dose (25 ng ml(-1)). Prostaglandins F 31-34 interleukin 1 beta Rattus norvegicus 13-21 14611637-7 2003 The observed reduction in progesterone synthesis at the lower dose of IL-1beta before the increase in PGF(2alpha) concentrations led to the hypothesis that IL-1beta regulates functional luteolysis (progesterone diminution) before it affects structural luteolysis (PGF(2alpha) increase). Prostaglandins F 102-105 interleukin 1 beta Rattus norvegicus 156-164 14611637-7 2003 The observed reduction in progesterone synthesis at the lower dose of IL-1beta before the increase in PGF(2alpha) concentrations led to the hypothesis that IL-1beta regulates functional luteolysis (progesterone diminution) before it affects structural luteolysis (PGF(2alpha) increase). Prostaglandins F 264-267 interleukin 1 beta Rattus norvegicus 156-164 12865306-0 2003 Prostaglandin F(2alpha) (PGF(2alpha)) and prolactin signaling: PGF(2alpha)-mediated inhibition of prolactin receptor expression in the Corpus luteum. Prostaglandins F 0-15 prolactin receptor Mus musculus 98-116 14504187-8 2003 CRP significantly decreased PGF-1alpha release from HAECs under basal (48% decrease, P<0.001; n=5) and stimulated (26% decrease, P<0.01; n=5) conditions. Prostaglandins F 28-31 C-reactive protein Homo sapiens 0-3 14555551-9 2003 CONCLUSIONS: Recipient diagnosis of PPH, donor African-American race, donor female gender, and donor age are independently and strongly associated with development of PGF. Prostaglandins F 167-170 enolase 1 Homo sapiens 36-39 12927819-5 2003 The addition of Ang II increased the generation of 8-epi-isoprostane PGF(2 alpha). Prostaglandins F 69-72 angiotensinogen Homo sapiens 16-22 12927819-6 2003 Inhibition of HO-1, by Stannis mesoporphyrin (SnMP), potentiated Ang II-mediated DNA damage and generation of 8-epi-isoprostane PGF(2 alpha). Prostaglandins F 128-131 heme oxygenase 1 Homo sapiens 14-18 12865306-0 2003 Prostaglandin F(2alpha) (PGF(2alpha)) and prolactin signaling: PGF(2alpha)-mediated inhibition of prolactin receptor expression in the Corpus luteum. Prostaglandins F 63-66 prolactin Mus musculus 42-51 12865306-0 2003 Prostaglandin F(2alpha) (PGF(2alpha)) and prolactin signaling: PGF(2alpha)-mediated inhibition of prolactin receptor expression in the Corpus luteum. Prostaglandins F 63-66 prolactin receptor Mus musculus 98-116 12865306-2 2003 We have previously shown that PGF(2alpha) inhibits the expression of several luteal genes stimulated by PRL, whereas it stimulates other genes inhibited by this hormone. Prostaglandins F 30-33 prolactin Mus musculus 104-107 12865306-3 2003 We have also found that PGF(2alpha) stimulation of 20alpha-hydroxysteroid dehydrogenase (20alphaHSD), an enzyme that catabolizes progesterone, at the end of pregnancy is accompanied by a dramatic decrease in PRL receptor (PRL-R) expression. Prostaglandins F 24-27 aldo-keto reductase family 1, member C18 Mus musculus 51-87 12865306-3 2003 We have also found that PGF(2alpha) stimulation of 20alpha-hydroxysteroid dehydrogenase (20alphaHSD), an enzyme that catabolizes progesterone, at the end of pregnancy is accompanied by a dramatic decrease in PRL receptor (PRL-R) expression. Prostaglandins F 24-27 prolactin receptor Mus musculus 208-220 12865306-3 2003 We have also found that PGF(2alpha) stimulation of 20alpha-hydroxysteroid dehydrogenase (20alphaHSD), an enzyme that catabolizes progesterone, at the end of pregnancy is accompanied by a dramatic decrease in PRL receptor (PRL-R) expression. Prostaglandins F 24-27 prolactin receptor Mus musculus 222-227 12865306-7 2003 Furthermore, administration of PGF(2alpha) to pregnant rats inhibited PRL-R expression. Prostaglandins F 31-34 prolactin receptor Rattus norvegicus 70-75 12865306-8 2003 Time-course analysis revealed that PGF(2alpha) treatment decreases both isoforms of PRL-R within 1 h of treatment in vivo, whereas its stimulatory effect on 20alphaHSD expression was further delayed. Prostaglandins F 35-38 prolactin receptor Mus musculus 84-89 12865306-12 2003 Taken together, these results demonstrate that PGF(2alpha) inhibits the expression of the PRL-R and that the decline in both forms of the PRL-R that occurs at the end of pregnancy in the CL is due to PGF(2alpha). Prostaglandins F 47-50 prolactin receptor Mus musculus 90-95 12865306-12 2003 Taken together, these results demonstrate that PGF(2alpha) inhibits the expression of the PRL-R and that the decline in both forms of the PRL-R that occurs at the end of pregnancy in the CL is due to PGF(2alpha). Prostaglandins F 200-203 prolactin receptor Mus musculus 138-143 12890581-9 2003 The MAP kinase blocker alone did not affect PGF, PGE and OT secretion but did prevent the stimulatory effects of GH on PGF and induced stimulatory action of GH (10 ng/ml) on PGE. Prostaglandins F 119-122 growth hormone 1 Homo sapiens 113-115 12890581-11 2003 These observations confirm the role of GH in regulating porcine ovarian PGF, PGE and OT secretion and the presence of ERK MAP kinase in porcine granulosa cells. Prostaglandins F 72-75 growth hormone 1 Homo sapiens 39-41 12890581-12 2003 Furthermore, our studies demonstrate that MAP kinase-dependent intracellular mechanisms are dependent on GH, and that these mechanisms are involved in the mediation of GH action on ovarian PGF and PGE but not OT secretion. Prostaglandins F 189-192 growth hormone 1 Homo sapiens 168-170 12880869-5 2003 However, this enzyme failed to produce PGF(2alpha) from endogenous AA, even though significant increase in PGF(2alpha) production occurred in cells transfected with COX-2 alone. Prostaglandins F 107-110 mitochondrially encoded cytochrome c oxidase II Homo sapiens 165-170 12880869-7 2003 Measurement of PGF(2alpha)-synthetic enzyme activity in homogenates of several cells revealed another type of PGFS activity that was membrane-bound, glutathione (GSH)-activated, and stimulus-inducible. Prostaglandins F 15-18 aldo-keto reductase family 1 member C3 Homo sapiens 110-114 12767686-7 2003 Furthermore, PGF(2alpha) (but not PGE(2)) clearly reduced the inhibition of TPA-induced promotion by NS-398, an isozyme-specific inhibitor of cyclooxygenase-2. Prostaglandins F 13-16 prostaglandin-endoperoxide synthase 2 Mus musculus 142-158 12890581-3 2003 The aims of this study on cultured porcine ovarian granulosa cells were to determine the effect of GH on the secretion of oxytocin (OT), PGF and PGE and whether MAP kinase could be involved in the mediation of GH action. Prostaglandins F 137-140 growth hormone 1 Homo sapiens 99-101 12890581-8 2003 GH stimulated the secretion of PGF (at a concentration of 1 ng GH per ml medium) and OT (100 ng GH per ml), but not PGE. Prostaglandins F 31-34 growth hormone 1 Homo sapiens 0-2 12890581-8 2003 GH stimulated the secretion of PGF (at a concentration of 1 ng GH per ml medium) and OT (100 ng GH per ml), but not PGE. Prostaglandins F 31-34 growth hormone 1 Homo sapiens 63-65 12890581-8 2003 GH stimulated the secretion of PGF (at a concentration of 1 ng GH per ml medium) and OT (100 ng GH per ml), but not PGE. Prostaglandins F 31-34 growth hormone 1 Homo sapiens 63-65 12788874-3 2003 We observed a significant increase in prostaglandin (PG)release after IL-1 beta treatment; the cytokine was more effective on PGE(2) than PGF(2 alpha) release. Prostaglandins F 138-141 interleukin 1 beta Homo sapiens 70-79 12631554-2 2003 The cellular effects of PGF(2alpha) are mediated by a G protein-coupled transmembrane receptor designated the FP receptor. Prostaglandins F 24-27 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase Mus musculus 110-112 12650831-0 2003 Prostaglandin F(2alpha) stimulation of cyclooxygenase-2 promoter activity by the FP(B) prostanoid receptor. Prostaglandins F 0-15 prostaglandin-endoperoxide synthase 2 Homo sapiens 39-55 12711247-1 2003 Prostaglandin F(2alpha) (PGF(2alpha)) has been reported to activate protein kinase C (PKC) through both phospholipase (PL) C and D, resulting in the proliferation of osteoblast-like cells. Prostaglandins F 0-15 perlecan (heparan sulfate proteoglycan 2) Mus musculus 104-130 12711247-1 2003 Prostaglandin F(2alpha) (PGF(2alpha)) has been reported to activate protein kinase C (PKC) through both phospholipase (PL) C and D, resulting in the proliferation of osteoblast-like cells. Prostaglandins F 25-28 perlecan (heparan sulfate proteoglycan 2) Mus musculus 104-130 12711247-2 2003 In addition, it has also been reported that Erk mitogen-activated protein kinase is also involved in the mechanism of PGF(2alpha)-induced proliferation of these cells. Prostaglandins F 118-121 mitogen-activated protein kinase 1 Mus musculus 44-47 12586490-11 2003 A higher percentage of PGPE(1)-treated cows in experiment 3 were observed in standing oestrus and ovulated after the second PGF(2alpha) injection (standing oestrus, 26.4, 34.3, and 62.6%, P<0.01; ovulated, 56, 63, and 78%, P<0.05; PP, PGP, and PGPE(1), respectively). Prostaglandins F 124-127 phosphoglycolate phosphatase Bos taurus 23-26 12586490-12 2003 In conclusion, the PGP protocol increased the number of cows that ovulated after the first PGF(2alpha) injection and produced a more mature dominant follicle at the time of the second PGF(2alpha) injection. Prostaglandins F 91-94 phosphoglycolate phosphatase Bos taurus 19-22 12586490-12 2003 In conclusion, the PGP protocol increased the number of cows that ovulated after the first PGF(2alpha) injection and produced a more mature dominant follicle at the time of the second PGF(2alpha) injection. Prostaglandins F 184-187 phosphoglycolate phosphatase Bos taurus 19-22 12679466-5 2003 To investigate this, we obtained Percoll-purified human chorion and placental trophoblast cells from uncomplicated term pregnancies and cultured them for 72 h. Activity of PGDH was assessed by incubation (4 h) with PGF(2alpha) (282 nM) and measurement of conversion to 13,14-dihydro-15-keto PG F(2alpha). Prostaglandins F 215-218 15-hydroxyprostaglandin dehydrogenase Homo sapiens 172-176 12828840-8 2003 PGF(2alpha) and latanoprost increased MLC phosphorylation in a concentration- and time-dependent manner, at 1 microM and 5 min incubation, the PGs increased the MLC response by 181 and 176% over basal, respectively. Prostaglandins F 0-3 modulator of VRAC current 1 Homo sapiens 38-41 12828840-8 2003 PGF(2alpha) and latanoprost increased MLC phosphorylation in a concentration- and time-dependent manner, at 1 microM and 5 min incubation, the PGs increased the MLC response by 181 and 176% over basal, respectively. Prostaglandins F 0-3 modulator of VRAC current 1 Homo sapiens 161-164 12828840-10 2003 Wortmannin, ML-7 and ML-9, selective inhibitors of MLC kinase, inhibited significantly PGF(2alpha)- and latanoprost-induced MLC phosphorylation and contraction. Prostaglandins F 87-90 solute carrier family 25 member 16 Homo sapiens 12-25 12828840-10 2003 Wortmannin, ML-7 and ML-9, selective inhibitors of MLC kinase, inhibited significantly PGF(2alpha)- and latanoprost-induced MLC phosphorylation and contraction. Prostaglandins F 87-90 modulator of VRAC current 1 Homo sapiens 51-54 12828840-10 2003 Wortmannin, ML-7 and ML-9, selective inhibitors of MLC kinase, inhibited significantly PGF(2alpha)- and latanoprost-induced MLC phosphorylation and contraction. Prostaglandins F 87-90 modulator of VRAC current 1 Homo sapiens 124-127 12738234-3 2003 In wild-type mice preconditioned with six cycles of 4-min coronary occlusion-4-min reperfusion, ischemic PC resulted in rapid activation of nuclear STAT1/3 through tyrosine phosphorylation (STAT1: 339 +/- 48% of control; STAT3: 389 +/- 46% of control) and increased STAT1/3-DNA binding activity (687 +/- 58% of control) at 30 min after PC, with subsequent upregulation of COX-2 protein (373 +/- 60% of control) and activity(increased myocardial levels of PGE2, PGF(2alpha), and 6-keto-PGF(1alpha)) at 24 h. However, COX-1 protein was not changed 24 h after ischemic PC. Prostaglandins F 461-464 signal transducer and activator of transcription 1 Mus musculus 148-155 12639911-2 2003 PGE(2) and PGF(2alpha) potently reverse indomethacin (INDO; a cyclooxygenase inhibitor) inhibition of IL-1beta autoinduction. Prostaglandins F 11-14 interleukin 1 beta Homo sapiens 102-110 12639911-3 2003 IL-1beta increases PGE(2) and PGF(2alpha) production. Prostaglandins F 30-33 interleukin 1 beta Homo sapiens 0-8 12639911-5 2003 Pharmacological characterization of receptors involved in PGE(2) and PGF(2alpha) regulation of IL-1beta mRNA levels was ascertained using real-time PCR analyses. Prostaglandins F 69-72 interleukin 1 beta Homo sapiens 95-103 12604658-2 2003 IFN-tau is believed to act by down-regulating estrogen receptors, thus preventing appearance of oxytocin receptors responsible for the release of prostaglandin F(2alpha) (PGF(2alpha)) by the endometrium. Prostaglandins F 146-161 interferon-tau-like Bos taurus 0-7 12604658-2 2003 IFN-tau is believed to act by down-regulating estrogen receptors, thus preventing appearance of oxytocin receptors responsible for the release of prostaglandin F(2alpha) (PGF(2alpha)) by the endometrium. Prostaglandins F 171-174 interferon-tau-like Bos taurus 0-7 12535846-6 2003 Bradykinin (10(-6) M) stimulated a marked increase in the production of 6-keto-PGF(1alpha), PGE(2), and PGF(2alpha) and a small increase of PGD(2) by ECs. Prostaglandins F 79-82 kininogen 1 Homo sapiens 0-10 12679480-9 2003 Moreover, treatment of Ishikawa cells with 100 nM PGF(2alpha) induced phosphorylation of ERK1/2 that was abolished when cells were cotreated with 50 micro M PD98059 (MAPK kinase inhibitor) or 10 micro M U73122 [phospholipase C (PLC) inhibitor]. Prostaglandins F 50-53 mitogen-activated protein kinase 3 Homo sapiens 89-95 12538781-1 2003 Basic fibroblast growth factor (bFGF or FGF-2), vascular endothelial growth factor (VEGF), and endothelin-1 (ET-1) are peptide growth factors (PGF) mediating normal lung development, maturation, injury, and repair. Prostaglandins F 143-146 fibroblast growth factor 2 Homo sapiens 32-36 12533422-2 2003 PG endoperoxide H synthase 2 (PGHS-2) mRNA expression increased in placenta in late gestation in association with an 8-fold increase in PGF(2alpha) concentration, reaching a peak on Gestational Day (GD) 18. Prostaglandins F 136-139 prostaglandin-endoperoxide synthase 2 Mus musculus 0-28 12533422-2 2003 PG endoperoxide H synthase 2 (PGHS-2) mRNA expression increased in placenta in late gestation in association with an 8-fold increase in PGF(2alpha) concentration, reaching a peak on Gestational Day (GD) 18. Prostaglandins F 136-139 prostaglandin-endoperoxide synthase 2 Mus musculus 30-36 12665673-5 2003 COX-2 transgenic mice demonstrate elevated levels of all prostaglandins and thromboxane, albeit with a predominant induction of PGE(2) over other prostaglandins, followed by more modest inductions of PGI(2), and relatively smaller increases in PGF(2alpha),PGD(2), and TxB(2). Prostaglandins F 244-247 prostaglandin-endoperoxide synthase 2 Mus musculus 0-5 12921694-10 2003 Oxytocin-induced PGF(2alpha) secretion from the apical surface was enhanced by chronic treatment with oestradiol, whereas that from the basolateral surface was enhanced by chronic treatment with progesterone. Prostaglandins F 17-20 oxytocin/neurophysin I prepropeptide Sus scrofa 0-8 12388163-4 2002 Pretreatment with anti-leukocyte antibody (CD18-directed monoclonal antibody, WT-3) significantly inhibited the PGF(2 alpha)-induced increases in adherent leukocytes and MPO activity. Prostaglandins F 112-115 integrin subunit beta 2 Rattus norvegicus 43-47 12388163-4 2002 Pretreatment with anti-leukocyte antibody (CD18-directed monoclonal antibody, WT-3) significantly inhibited the PGF(2 alpha)-induced increases in adherent leukocytes and MPO activity. Prostaglandins F 112-115 myeloperoxidase Rattus norvegicus 170-173 12388163-6 2002 Pretreatment with oxygen free radical scavengers, superoxide dismutase (50,000 U/kg) and catalase (90,000 U/kg), also attenuated these PGF(2 alpha)-induced alterations. Prostaglandins F 135-138 catalase Rattus norvegicus 72-97 12244105-3 2002 In cellular systems, glycerol esters and ethanolamides of PGE(2), PGD(2), and PGF(2alpha) were major products of the endocannabinoid-derived COX-2 products, PGH(2)-G and PGH(2)-EA. Prostaglandins F 78-81 prostaglandin-endoperoxide synthase 2 Bos taurus 141-146 12617986-7 2002 PGF(2alpha) an agent known to inactivate PPARgamma, diminished the stimulatory effect of pioglitazone and PGJ2 on TM protein expression. Prostaglandins F 0-3 peroxisome proliferator activated receptor gamma Homo sapiens 41-50 12538781-1 2003 Basic fibroblast growth factor (bFGF or FGF-2), vascular endothelial growth factor (VEGF), and endothelin-1 (ET-1) are peptide growth factors (PGF) mediating normal lung development, maturation, injury, and repair. Prostaglandins F 143-146 fibroblast growth factor 2 Homo sapiens 40-45 12538781-1 2003 Basic fibroblast growth factor (bFGF or FGF-2), vascular endothelial growth factor (VEGF), and endothelin-1 (ET-1) are peptide growth factors (PGF) mediating normal lung development, maturation, injury, and repair. Prostaglandins F 143-146 vascular endothelial growth factor A Homo sapiens 48-82 12538781-1 2003 Basic fibroblast growth factor (bFGF or FGF-2), vascular endothelial growth factor (VEGF), and endothelin-1 (ET-1) are peptide growth factors (PGF) mediating normal lung development, maturation, injury, and repair. Prostaglandins F 143-146 vascular endothelial growth factor A Homo sapiens 84-88 12538781-1 2003 Basic fibroblast growth factor (bFGF or FGF-2), vascular endothelial growth factor (VEGF), and endothelin-1 (ET-1) are peptide growth factors (PGF) mediating normal lung development, maturation, injury, and repair. Prostaglandins F 143-146 endothelin 1 Homo sapiens 95-107 12538781-1 2003 Basic fibroblast growth factor (bFGF or FGF-2), vascular endothelial growth factor (VEGF), and endothelin-1 (ET-1) are peptide growth factors (PGF) mediating normal lung development, maturation, injury, and repair. Prostaglandins F 143-146 endothelin 1 Homo sapiens 109-113 12239110-8 2002 Therefore, induction of SOCS-3 by PGF(2alpha) may be an important element in the initiation of luteolysis via rapid suppression of luteotropic support from PL. Prostaglandins F 34-37 suppressor of cytokine signaling 3 Rattus norvegicus 24-30 12372399-0 2002 Prostaglandin F(2alpha) stimulates tyrosine phosphorylation of phospholipase C-gamma1. Prostaglandins F 0-15 phospholipase C gamma 1 Homo sapiens 63-85 12372399-1 2002 In this study, we investigated the ability of prostaglandin F(2alpha) (PGF(2alpha)) to induce tyrosine phosphorylation of phospholipase C-gamma1 (PLC-gamma1) in cat iris sphincter smooth muscle (CISM) cells. Prostaglandins F 46-61 phospholipase C gamma 1 Homo sapiens 122-144 12372399-1 2002 In this study, we investigated the ability of prostaglandin F(2alpha) (PGF(2alpha)) to induce tyrosine phosphorylation of phospholipase C-gamma1 (PLC-gamma1) in cat iris sphincter smooth muscle (CISM) cells. Prostaglandins F 46-61 phospholipase C gamma 1 Homo sapiens 146-156 12372399-1 2002 In this study, we investigated the ability of prostaglandin F(2alpha) (PGF(2alpha)) to induce tyrosine phosphorylation of phospholipase C-gamma1 (PLC-gamma1) in cat iris sphincter smooth muscle (CISM) cells. Prostaglandins F 71-74 phospholipase C gamma 1 Homo sapiens 122-144 12372399-1 2002 In this study, we investigated the ability of prostaglandin F(2alpha) (PGF(2alpha)) to induce tyrosine phosphorylation of phospholipase C-gamma1 (PLC-gamma1) in cat iris sphincter smooth muscle (CISM) cells. Prostaglandins F 71-74 phospholipase C gamma 1 Homo sapiens 146-156 12372399-2 2002 PGF(2alpha)(1 microM) stimulated PLC-gamma1 tyrosine phosphorylation in a time- and dose-dependent manner with a maximum increase of 3-fold at 0.5min. Prostaglandins F 0-3 phospholipase C gamma 1 Homo sapiens 33-43 12372399-4 2002 Furthermore, PGF(2alpha)-induced p42/p44 MAP kinase activation was also completely blocked by protein tyrosine kinase inhibitors. Prostaglandins F 13-16 cyclin dependent kinase 20 Homo sapiens 33-36 12372399-4 2002 Furthermore, PGF(2alpha)-induced p42/p44 MAP kinase activation was also completely blocked by protein tyrosine kinase inhibitors. Prostaglandins F 13-16 interferon induced protein 44 Homo sapiens 37-40 12372399-5 2002 In summary, these findings show that PGF(2alpha) stimulates tyrosine phosphorylation of PLC-gamma1 in CISM cells and indicate that PGF(2alpha)-stimulated tyrosine phosphorylation is responsible for an early signal transduction event. Prostaglandins F 37-40 phospholipase C gamma 1 Homo sapiens 88-98 12372399-5 2002 In summary, these findings show that PGF(2alpha) stimulates tyrosine phosphorylation of PLC-gamma1 in CISM cells and indicate that PGF(2alpha)-stimulated tyrosine phosphorylation is responsible for an early signal transduction event. Prostaglandins F 131-134 phospholipase C gamma 1 Homo sapiens 88-98 12450738-2 2002 CGRP (0.01-1 nmol), VIP (0.01-10 nmol) and SP (0.1-100 nmol) produced vasodilation in PGF(2 alpha) (10 microM)-induced contraction of mesenteric vascular beds isolated from OVX and sham-operated rats in a dose-dependent manner. Prostaglandins F 86-89 calcitonin-related polypeptide alpha Rattus norvegicus 0-4 12450738-2 2002 CGRP (0.01-1 nmol), VIP (0.01-10 nmol) and SP (0.1-100 nmol) produced vasodilation in PGF(2 alpha) (10 microM)-induced contraction of mesenteric vascular beds isolated from OVX and sham-operated rats in a dose-dependent manner. Prostaglandins F 86-89 vasoactive intestinal peptide Rattus norvegicus 20-23 12087084-0 2002 Prostaglandin F(2alpha), cytokines and cyclic mechanical stretch augment matrix metalloproteinase-1 secretion from cultured human uterine cervical fibroblast cells. Prostaglandins F 0-15 matrix metallopeptidase 1 Homo sapiens 73-99 12221288-7 2002 Thus, COX-2 overexpression, which leads to high levels of epidermal prostaglandin E(2), prostaglandin F(2alpha), and 15-deoxy(delta12,14)-PGJ(2), is insufficient for tumor induction but transforms epidermis into an "autopromoted" state, i.e., dramatically sensitizes the tissue for genotoxic carcinogens. Prostaglandins F 88-103 prostaglandin-endoperoxide synthase 2 Mus musculus 6-11 12193539-10 2002 PGE(2), PGF(2alpha), and PGI(2) measurements show that IL-1beta treatment significantly increases progenitor Leydig cell production of these PGs. Prostaglandins F 8-11 interleukin 1 beta Rattus norvegicus 55-63 12383914-1 2002 OBJECTIVE: It has been well established that oxytocin (OXT) increases intracellular free calcium ([Ca(2+)](i)) by targeting both intracellular and extracellular stores, but the mechanisms involved in the increase through activation with prostaglandin F(2alpha) (PGF(2alpha)) are still incompletely understood. Prostaglandins F 237-252 oxytocin/neurophysin I prepropeptide Rattus norvegicus 45-53 12383914-1 2002 OBJECTIVE: It has been well established that oxytocin (OXT) increases intracellular free calcium ([Ca(2+)](i)) by targeting both intracellular and extracellular stores, but the mechanisms involved in the increase through activation with prostaglandin F(2alpha) (PGF(2alpha)) are still incompletely understood. Prostaglandins F 237-252 oxytocin/neurophysin I prepropeptide Rattus norvegicus 55-58 12383914-1 2002 OBJECTIVE: It has been well established that oxytocin (OXT) increases intracellular free calcium ([Ca(2+)](i)) by targeting both intracellular and extracellular stores, but the mechanisms involved in the increase through activation with prostaglandin F(2alpha) (PGF(2alpha)) are still incompletely understood. Prostaglandins F 262-265 oxytocin/neurophysin I prepropeptide Rattus norvegicus 45-53 12383914-1 2002 OBJECTIVE: It has been well established that oxytocin (OXT) increases intracellular free calcium ([Ca(2+)](i)) by targeting both intracellular and extracellular stores, but the mechanisms involved in the increase through activation with prostaglandin F(2alpha) (PGF(2alpha)) are still incompletely understood. Prostaglandins F 262-265 oxytocin/neurophysin I prepropeptide Rattus norvegicus 55-58 12211063-1 2002 The possible mediatory role of endothelin-1 (ET-1) in prostaglandin F(2alpha) (PGF(2alpha))-induced luteolysis in the rat was examined. Prostaglandins F 54-69 endothelin 1 Rattus norvegicus 45-49 12211063-7 2002 On the other hand, this PGF(2alpha) analog induced expression of luteal VEGF mRNA. Prostaglandins F 24-27 vascular endothelial growth factor A Rattus norvegicus 72-76 12211063-9 2002 The inhibitory effect of PGF(2alpha) was reversed by BQ123 (10(- 7) M), that is a selective ETA receptor antagonist. Prostaglandins F 25-28 endothelin receptor type A Rattus norvegicus 92-95 12211063-10 2002 We conclude that the PGF(2alpha)-induced elevation in luteal expression of ET-1 combined with the reversal of its luteolytic effect by an ETA receptor antagonist suggest that ET-1 may take part in the PGF(2alpha)-induced luteolysis in the rat. Prostaglandins F 21-24 endothelin 1 Rattus norvegicus 75-79 12211063-10 2002 We conclude that the PGF(2alpha)-induced elevation in luteal expression of ET-1 combined with the reversal of its luteolytic effect by an ETA receptor antagonist suggest that ET-1 may take part in the PGF(2alpha)-induced luteolysis in the rat. Prostaglandins F 21-24 endothelin receptor type A Rattus norvegicus 138-141 12211063-10 2002 We conclude that the PGF(2alpha)-induced elevation in luteal expression of ET-1 combined with the reversal of its luteolytic effect by an ETA receptor antagonist suggest that ET-1 may take part in the PGF(2alpha)-induced luteolysis in the rat. Prostaglandins F 21-24 endothelin 1 Rattus norvegicus 175-179 12211063-10 2002 We conclude that the PGF(2alpha)-induced elevation in luteal expression of ET-1 combined with the reversal of its luteolytic effect by an ETA receptor antagonist suggest that ET-1 may take part in the PGF(2alpha)-induced luteolysis in the rat. Prostaglandins F 201-204 endothelin 1 Rattus norvegicus 75-79 12211063-10 2002 We conclude that the PGF(2alpha)-induced elevation in luteal expression of ET-1 combined with the reversal of its luteolytic effect by an ETA receptor antagonist suggest that ET-1 may take part in the PGF(2alpha)-induced luteolysis in the rat. Prostaglandins F 201-204 endothelin receptor type A Rattus norvegicus 138-141 12211063-10 2002 We conclude that the PGF(2alpha)-induced elevation in luteal expression of ET-1 combined with the reversal of its luteolytic effect by an ETA receptor antagonist suggest that ET-1 may take part in the PGF(2alpha)-induced luteolysis in the rat. Prostaglandins F 201-204 endothelin 1 Rattus norvegicus 175-179 12143044-5 2002 HGF and IL-6 also induced a rapid release of arachidonic acid (AA) from SG231 and increased the synthesis of PGE(2) and PGF(2)alpha. Prostaglandins F 120-123 hepatocyte growth factor Homo sapiens 0-3 12143044-5 2002 HGF and IL-6 also induced a rapid release of arachidonic acid (AA) from SG231 and increased the synthesis of PGE(2) and PGF(2)alpha. Prostaglandins F 120-123 interleukin 6 Homo sapiens 8-12 12141944-10 2002 Treatment with 1/4 PGF(2alpha)/Ang II decreased plasma progesterone concentration, and induced luteolysis and oestrus. Prostaglandins F 19-22 ANG Bos taurus 31-34 12141944-11 2002 The onset of oestrus in cows treated with full-dose (500 microg) PGF(2alpha) (3.1 +/- 0.2 (mean +/- SEM) days after treatment) was significantly earlier than that in cows treated with 1/4 PGF(2alpha)/Ang II (4.8 +/- 0.2 days after treatment) (P < 0.05). Prostaglandins F 65-68 ANG Bos taurus 200-203 12141945-2 2002 Superfusion of day 7 guinea-pig uterus in vitro with either EGF or sodium nitroprusside increased the output of PGF(2alpha) and 6-keto-PGF(1alpha), but not of PGE(2). Prostaglandins F 112-115 pro-epidermal growth factor Cavia porcellus 60-63 12141945-4 2002 EGF still increased the output of PGF(2alpha), but did not increase the output of 6-keto-PGF(1alpha) in a calcium-depleted superfusate. Prostaglandins F 34-37 pro-epidermal growth factor Cavia porcellus 0-3 12141945-9 2002 Overall, the findings indicate that EGF and nitric oxide may act as mediators in the mechanism by which oestradiol acting on a progesterone-primed uterus stimulates the increase in PGF(2alpha) production by the guinea-pig uterus necessary for luteolysis. Prostaglandins F 181-184 pro-epidermal growth factor Cavia porcellus 36-39 12117548-0 2002 c-fos mRNA expression associated with PGF(2alpha)-induced nest-building behaviour in female pigs. Prostaglandins F 38-41 protein c-Fos Sus scrofa 0-5 12117548-11 2002 PGF(2alpha)-treated pigs had significantly higher levels of c-fos mRNA expression than saline-treated pigs in the parvocellular and magnocellular regions of the hypothalamic paraventricular nucleus, the supraoptic nucleus (including the pars dorso-medialis), the neural lobe of the pituitary gland and the cerebellum. Prostaglandins F 0-3 protein c-Fos Sus scrofa 60-65 12117548-12 2002 PGF(2alpha)-treated pigs also had significantly higher c-fos induction in corpus luteum. Prostaglandins F 0-3 protein c-Fos Sus scrofa 55-60 12117548-13 2002 These data show that the pattern of c-fos mRNA expression in specific brain areas is different between pigs that show PGF(2alpha)-induced nest building and saline-injected controls. Prostaglandins F 118-121 protein c-Fos Sus scrofa 36-41 12142242-3 2002 It has been recently demonstrated that tumor necrosis factor-alpha (TNF-alpha) stimulates PGF(2alpha) output from bovine endometrial tissue not only during the follicular phase but also during the late luteal phase, suggesting that TNF-alpha is a factor in the initiation of luteolysis in cattle. Prostaglandins F 90-93 tumor necrosis factor Bos taurus 39-66 12142242-3 2002 It has been recently demonstrated that tumor necrosis factor-alpha (TNF-alpha) stimulates PGF(2alpha) output from bovine endometrial tissue not only during the follicular phase but also during the late luteal phase, suggesting that TNF-alpha is a factor in the initiation of luteolysis in cattle. Prostaglandins F 90-93 tumor necrosis factor Bos taurus 68-77 12142242-3 2002 It has been recently demonstrated that tumor necrosis factor-alpha (TNF-alpha) stimulates PGF(2alpha) output from bovine endometrial tissue not only during the follicular phase but also during the late luteal phase, suggesting that TNF-alpha is a factor in the initiation of luteolysis in cattle. Prostaglandins F 90-93 tumor necrosis factor Bos taurus 232-241 12142242-4 2002 Furthermore, our recent study has shown that IFN-tau suppresses the action of TNF-alpha on PGF(2alpha) synthesis by the bovine endometrium in vitro, suggesting that IFN-tau plays a luteoprotective role by inhibiting TNF-alpha-induced PGF(2alpha) production in early pregnancy. Prostaglandins F 91-94 interferon-tau-like Bos taurus 45-52 12142242-4 2002 Furthermore, our recent study has shown that IFN-tau suppresses the action of TNF-alpha on PGF(2alpha) synthesis by the bovine endometrium in vitro, suggesting that IFN-tau plays a luteoprotective role by inhibiting TNF-alpha-induced PGF(2alpha) production in early pregnancy. Prostaglandins F 91-94 tumor necrosis factor Bos taurus 78-87 12142242-4 2002 Furthermore, our recent study has shown that IFN-tau suppresses the action of TNF-alpha on PGF(2alpha) synthesis by the bovine endometrium in vitro, suggesting that IFN-tau plays a luteoprotective role by inhibiting TNF-alpha-induced PGF(2alpha) production in early pregnancy. Prostaglandins F 91-94 interferon-tau-like Bos taurus 165-172 12142242-4 2002 Furthermore, our recent study has shown that IFN-tau suppresses the action of TNF-alpha on PGF(2alpha) synthesis by the bovine endometrium in vitro, suggesting that IFN-tau plays a luteoprotective role by inhibiting TNF-alpha-induced PGF(2alpha) production in early pregnancy. Prostaglandins F 234-237 interferon-tau-like Bos taurus 45-52 12142242-4 2002 Furthermore, our recent study has shown that IFN-tau suppresses the action of TNF-alpha on PGF(2alpha) synthesis by the bovine endometrium in vitro, suggesting that IFN-tau plays a luteoprotective role by inhibiting TNF-alpha-induced PGF(2alpha) production in early pregnancy. Prostaglandins F 234-237 tumor necrosis factor Bos taurus 78-87 12142242-4 2002 Furthermore, our recent study has shown that IFN-tau suppresses the action of TNF-alpha on PGF(2alpha) synthesis by the bovine endometrium in vitro, suggesting that IFN-tau plays a luteoprotective role by inhibiting TNF-alpha-induced PGF(2alpha) production in early pregnancy. Prostaglandins F 234-237 interferon-tau-like Bos taurus 165-172 12142244-10 2002 One such factor is monocyte chemoattractant protein (MCP-1), which increases after exogenous PGF(2alpha). Prostaglandins F 93-96 C-C motif chemokine 2 Bos taurus 53-58 12142248-5 2002 The increasing levels of oestrone are time-related to an increased synthesis of prostaglandin F(2alpha) (reflected as elevated levels of 15-ketodihydro-PGF(2alpha)) causing prepartal luteolysis and several hormones are then involved in the labour process such as prostaglandin F(2alpha), cortisol and oxytocin. Prostaglandins F 80-95 placental growth factor Bos taurus 152-155 12090913-4 2002 Later increases in maternal uterine expression of PGHS-2 require increases in oestrogen and lead to increased concentrations of PGF(2alpha) in the maternal circulation. Prostaglandins F 128-131 prostaglandin-endoperoxide synthase 2 Homo sapiens 50-56 12012326-7 2002 These effects were PPARgamma specific because clofibrate or PGF(2alpha) did not affect proliferation of urothelial cells. Prostaglandins F 60-63 peroxisome proliferator activated receptor gamma Homo sapiens 19-28 12087084-9 2002 These data suggest that MMP-1 may play a significant role in the degradation of extracellular collagen types I and III in the pregnant uterine cervix during the process of cervical ripening, in response to various stimulations such as PGF(2alpha), IL-1alpha and mechanical stretch. Prostaglandins F 235-238 matrix metallopeptidase 1 Homo sapiens 24-29 12087084-9 2002 These data suggest that MMP-1 may play a significant role in the degradation of extracellular collagen types I and III in the pregnant uterine cervix during the process of cervical ripening, in response to various stimulations such as PGF(2alpha), IL-1alpha and mechanical stretch. Prostaglandins F 235-238 interleukin 1 alpha Homo sapiens 248-257 12042419-7 2002 Moreover, HepG2 cells treated with 100 micromol/L of trans-10,cis-12 CLA released larger amounts of 6-keto-prostaglandin F(1alpha) and prostaglandin F(2alpha) than control cells. Prostaglandins F 107-122 selectin P ligand Homo sapiens 69-72 12023506-4 2002 hOAT2 mediated a time- and concentration-dependent increase in prostaglandin F(2alpha) (PGF(2alpha)) uptake. Prostaglandins F 63-78 solute carrier family 22 member 7 Homo sapiens 0-5 12023506-4 2002 hOAT2 mediated a time- and concentration-dependent increase in prostaglandin F(2alpha) (PGF(2alpha)) uptake. Prostaglandins F 88-91 solute carrier family 22 member 7 Homo sapiens 0-5 12023506-6 2002 Probenecid, but not KW-3902, betamipron, and cilastatin, significantly inhibited hOAT2-mediated PGF(2alpha) uptake. Prostaglandins F 96-99 solute carrier family 22 member 7 Homo sapiens 81-86 12023506-10 2002 These results suggest that probenecid, KW-3902, and betamipron could inhibit hOAT4-mediated ES uptake in vitro, whereas probenecid alone could inhibit the hOAT2-mediated PGF(2alpha) uptake. Prostaglandins F 170-173 solute carrier family 22 member 7 Homo sapiens 155-160 12106612-2 2002 Previously, we reported AA release and prostaglandin F(2alpha) (PGF(2alpha)) formation via activation of cytosolic PLA2 by orthovanadate (Na3VO4), an inhibitor of tyrosine phosphatases, in rat pheochromocytoma PC12 cells. Prostaglandins F 39-54 phospholipase A2 group IB Rattus norvegicus 115-119 12106612-2 2002 Previously, we reported AA release and prostaglandin F(2alpha) (PGF(2alpha)) formation via activation of cytosolic PLA2 by orthovanadate (Na3VO4), an inhibitor of tyrosine phosphatases, in rat pheochromocytoma PC12 cells. Prostaglandins F 64-67 phospholipase A2 group IB Rattus norvegicus 115-119 12061859-11 2002 In conclusion, the present results suggest that ET-1 and Ang II may play differential tissue-specific roles in the placental unit that may amplify the local endocrinological cascade involving OT, OT-R and PGF(2alpha) interactions which are necessary for normal placental separation in the cow. Prostaglandins F 205-208 endothelin 1 Bos taurus 48-63 11832489-6 2002 In PGF(2alpha) or (+)-fluprostenol-treated cells, a dose-dependent increase in the expression of NOX1, a homolog of the catalytic subunit of the phagocyte NADPH oxidase gp91(phox), was demonstrated by Northern blot analysis. Prostaglandins F 3-6 NADPH oxidase 1 Rattus norvegicus 97-101 11967202-10 2002 These data suggest that an early and sustained effect of PGF(2alpha) is the specific depletion of TIMP-1 within LLCs that are capable of responding to the luteolytic action of PGF(2alpha). Prostaglandins F 57-60 TIMP metallopeptidase inhibitor 1 Homo sapiens 98-104 11967202-10 2002 These data suggest that an early and sustained effect of PGF(2alpha) is the specific depletion of TIMP-1 within LLCs that are capable of responding to the luteolytic action of PGF(2alpha). Prostaglandins F 176-179 TIMP metallopeptidase inhibitor 1 Homo sapiens 98-104 11923256-1 2002 PURPOSE: Prostaglandin (PG) F(2alpha) and other Ca(2+)-mobilizing agonists, such as carbachol (CCh) and endothelin (ET)-1, induce an increase in uveoscleral outflow, in part through receptor-mediated mechanisms in the ciliary muscle. Prostaglandins F 9-29 endothelin 1 Homo sapiens 104-121 11907186-7 2002 In conclusion, considering the localization of these transporters, the results suggest that PGE(2) and PGF(2 alpha) transport in the basolateral membrane of the proximal tubule is mediated by multiple pathways including hOAT1, hOAT2, hOAT3, and hOCT2, whereas that in the apical side is mediated by hOAT4. Prostaglandins F 103-106 solute carrier family 22 member 6 Homo sapiens 220-225 11907186-7 2002 In conclusion, considering the localization of these transporters, the results suggest that PGE(2) and PGF(2 alpha) transport in the basolateral membrane of the proximal tubule is mediated by multiple pathways including hOAT1, hOAT2, hOAT3, and hOCT2, whereas that in the apical side is mediated by hOAT4. Prostaglandins F 103-106 solute carrier family 22 member 7 Homo sapiens 227-232 11907186-7 2002 In conclusion, considering the localization of these transporters, the results suggest that PGE(2) and PGF(2 alpha) transport in the basolateral membrane of the proximal tubule is mediated by multiple pathways including hOAT1, hOAT2, hOAT3, and hOCT2, whereas that in the apical side is mediated by hOAT4. Prostaglandins F 103-106 solute carrier family 22 member 8 Homo sapiens 234-239 11907186-7 2002 In conclusion, considering the localization of these transporters, the results suggest that PGE(2) and PGF(2 alpha) transport in the basolateral membrane of the proximal tubule is mediated by multiple pathways including hOAT1, hOAT2, hOAT3, and hOCT2, whereas that in the apical side is mediated by hOAT4. Prostaglandins F 103-106 POU class 2 homeobox 2 Homo sapiens 245-250 11907186-7 2002 In conclusion, considering the localization of these transporters, the results suggest that PGE(2) and PGF(2 alpha) transport in the basolateral membrane of the proximal tubule is mediated by multiple pathways including hOAT1, hOAT2, hOAT3, and hOCT2, whereas that in the apical side is mediated by hOAT4. Prostaglandins F 103-106 solute carrier family 22 member 11 Homo sapiens 299-304 11901221-4 2002 The TXA(2) mimetic 9,11-dideoxy-9alpha,11alpha-methano epoxy prostaglandin F(2alpha) (U46619) elicited concentration- and time-dependent activation of ERK1 and -2 through both TPs with maximal TPalpha- and TPbeta-mediated ERK activation observed after 10 and 5 min, respectively. Prostaglandins F 61-76 mitogen-activated protein kinase 3 Homo sapiens 151-162 11901221-4 2002 The TXA(2) mimetic 9,11-dideoxy-9alpha,11alpha-methano epoxy prostaglandin F(2alpha) (U46619) elicited concentration- and time-dependent activation of ERK1 and -2 through both TPs with maximal TPalpha- and TPbeta-mediated ERK activation observed after 10 and 5 min, respectively. Prostaglandins F 61-76 plasminogen activator, tissue type Homo sapiens 193-200 11901221-4 2002 The TXA(2) mimetic 9,11-dideoxy-9alpha,11alpha-methano epoxy prostaglandin F(2alpha) (U46619) elicited concentration- and time-dependent activation of ERK1 and -2 through both TPs with maximal TPalpha- and TPbeta-mediated ERK activation observed after 10 and 5 min, respectively. Prostaglandins F 61-76 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Homo sapiens 206-212 11901221-4 2002 The TXA(2) mimetic 9,11-dideoxy-9alpha,11alpha-methano epoxy prostaglandin F(2alpha) (U46619) elicited concentration- and time-dependent activation of ERK1 and -2 through both TPs with maximal TPalpha- and TPbeta-mediated ERK activation observed after 10 and 5 min, respectively. Prostaglandins F 61-76 mitogen-activated protein kinase 1 Homo sapiens 151-154 11841911-3 2002 It was found (using RIA/IRMA) that GH addition to culture medium significantly stimulated IGF-I and PGF release and inhibited IGFBP-3 and OT secretion. Prostaglandins F 100-103 growth hormone 1 Homo sapiens 35-37 11841911-7 2002 Furthermore, PKA blockers were able to prevent stimulatory effects of GH on IGF-I and PGF release, and inhibitory effect of GH on IGFBP-3, OT output and on apoptosis. Prostaglandins F 86-89 growth hormone 1 Homo sapiens 70-72 11855829-3 2002 In the present study on cultured rat hepatocytes we show that although the comitogenic GPCR agonists prostaglandin F(2alpha), vasopressin, angiotensin II, and norepinephrine all activated ERK, blocking of the ERK pathway with the MEK inhibitor PD 98059 did not abolish their comitogenic effects. Prostaglandins F 101-116 Eph receptor B1 Rattus norvegicus 188-191 11855829-3 2002 In the present study on cultured rat hepatocytes we show that although the comitogenic GPCR agonists prostaglandin F(2alpha), vasopressin, angiotensin II, and norepinephrine all activated ERK, blocking of the ERK pathway with the MEK inhibitor PD 98059 did not abolish their comitogenic effects. Prostaglandins F 101-116 Eph receptor B1 Rattus norvegicus 209-212 11870370-6 2002 PGE(2) and prostaglandin F(2alpha) (PGF(2)alpha) (3-6mug/mL), added directly to the culture medium, significantly up-regulated intrinsic mdr1b mRNA overexpression and mdr1-dependent transport activity. Prostaglandins F 11-26 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 137-142 11870370-6 2002 PGE(2) and prostaglandin F(2alpha) (PGF(2)alpha) (3-6mug/mL), added directly to the culture medium, significantly up-regulated intrinsic mdr1b mRNA overexpression and mdr1-dependent transport activity. Prostaglandins F 11-26 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 137-141 11967202-2 2002 Therefore, we hypothesized that prostaglandin (PG) F(2alpha) administration would decrease expression of the tissue inhibitor of metalloproteinase (TIMP)-1, -2, and -3 and effectively increase the MMP:TIMP ratio, leading to glandular involution. Prostaglandins F 32-52 TIMP metallopeptidase inhibitor 1 Homo sapiens 109-167 11967202-2 2002 Therefore, we hypothesized that prostaglandin (PG) F(2alpha) administration would decrease expression of the tissue inhibitor of metalloproteinase (TIMP)-1, -2, and -3 and effectively increase the MMP:TIMP ratio, leading to glandular involution. Prostaglandins F 32-52 TIMP metallopeptidase inhibitor 1 Homo sapiens 148-152 11967202-3 2002 In experiment 1, we tested the effects of PGF(2alpha) administration (Day 10 postestrus; Day 0 = estrus) on luteal TIMP-1, -2, and -3 mRNA and protein expression. Prostaglandins F 42-45 TIMP metallopeptidase inhibitor 1 Homo sapiens 115-133 11967202-5 2002 Following PGF(2alpha) administration, TIMP-1 mRNA levels decreased (P < 0.05) at 1 and 2 h relative to 0 h (controls), then increased to levels greater than controls at 4 and 6 h. In contrast, TIMP-2 and -3 mRNA levels did not decrease following PGF(2alpha) administration. Prostaglandins F 10-13 TIMP metallopeptidase inhibitor 1 Homo sapiens 38-44 11967202-5 2002 Following PGF(2alpha) administration, TIMP-1 mRNA levels decreased (P < 0.05) at 1 and 2 h relative to 0 h (controls), then increased to levels greater than controls at 4 and 6 h. In contrast, TIMP-2 and -3 mRNA levels did not decrease following PGF(2alpha) administration. Prostaglandins F 10-13 TIMP metallopeptidase inhibitor 2 Homo sapiens 196-209 11967202-5 2002 Following PGF(2alpha) administration, TIMP-1 mRNA levels decreased (P < 0.05) at 1 and 2 h relative to 0 h (controls), then increased to levels greater than controls at 4 and 6 h. In contrast, TIMP-2 and -3 mRNA levels did not decrease following PGF(2alpha) administration. Prostaglandins F 249-252 TIMP metallopeptidase inhibitor 1 Homo sapiens 38-44 11967202-7 2002 However, histodepletion of TIMP-1 within LLCs was evident within 30 min (earliest time point collected) following PGF(2alpha) injection and continued through 48 h. Luteal concentration of TIMP-1, as determined by RIA, was decreased (P < 0.05) by 15 min (earliest time point collected) following PGF(2alpha) administration and remained low through 48 h. In contrast, TIMP-2 and -3 immunolocalization was not altered by PGF(2alpha) administration. Prostaglandins F 114-117 TIMP metallopeptidase inhibitor 1 Homo sapiens 27-33 11967202-7 2002 However, histodepletion of TIMP-1 within LLCs was evident within 30 min (earliest time point collected) following PGF(2alpha) injection and continued through 48 h. Luteal concentration of TIMP-1, as determined by RIA, was decreased (P < 0.05) by 15 min (earliest time point collected) following PGF(2alpha) administration and remained low through 48 h. In contrast, TIMP-2 and -3 immunolocalization was not altered by PGF(2alpha) administration. Prostaglandins F 298-301 TIMP metallopeptidase inhibitor 1 Homo sapiens 27-33 11967202-7 2002 However, histodepletion of TIMP-1 within LLCs was evident within 30 min (earliest time point collected) following PGF(2alpha) injection and continued through 48 h. Luteal concentration of TIMP-1, as determined by RIA, was decreased (P < 0.05) by 15 min (earliest time point collected) following PGF(2alpha) administration and remained low through 48 h. In contrast, TIMP-2 and -3 immunolocalization was not altered by PGF(2alpha) administration. Prostaglandins F 298-301 TIMP metallopeptidase inhibitor 1 Homo sapiens 188-194 11967202-7 2002 However, histodepletion of TIMP-1 within LLCs was evident within 30 min (earliest time point collected) following PGF(2alpha) injection and continued through 48 h. Luteal concentration of TIMP-1, as determined by RIA, was decreased (P < 0.05) by 15 min (earliest time point collected) following PGF(2alpha) administration and remained low through 48 h. In contrast, TIMP-2 and -3 immunolocalization was not altered by PGF(2alpha) administration. Prostaglandins F 298-301 TIMP metallopeptidase inhibitor 1 Homo sapiens 27-33 11967202-7 2002 However, histodepletion of TIMP-1 within LLCs was evident within 30 min (earliest time point collected) following PGF(2alpha) injection and continued through 48 h. Luteal concentration of TIMP-1, as determined by RIA, was decreased (P < 0.05) by 15 min (earliest time point collected) following PGF(2alpha) administration and remained low through 48 h. In contrast, TIMP-2 and -3 immunolocalization was not altered by PGF(2alpha) administration. Prostaglandins F 298-301 TIMP metallopeptidase inhibitor 1 Homo sapiens 188-194 11967202-8 2002 Experiment 2 was conducted to determine if PGF(2alpha) could initiate the preceding changes in TIMP-1 in early (Day 3) corpora lutea that can bind PGF(2alpha) but are refractory to its luteolytic effects. Prostaglandins F 43-46 TIMP metallopeptidase inhibitor 1 Homo sapiens 95-101 11967202-8 2002 Experiment 2 was conducted to determine if PGF(2alpha) could initiate the preceding changes in TIMP-1 in early (Day 3) corpora lutea that can bind PGF(2alpha) but are refractory to its luteolytic effects. Prostaglandins F 147-150 TIMP metallopeptidase inhibitor 1 Homo sapiens 95-101 11907186-4 2002 A time- and dose-dependent increase in PGE(2) and PGF(2 alpha) uptake was observed in cells expressing hOAT1, hOAT2, hOAT3, hOAT4, hOCT1, and hOCT2. Prostaglandins F 50-53 solute carrier family 22 member 6 Homo sapiens 103-108 11907186-4 2002 A time- and dose-dependent increase in PGE(2) and PGF(2 alpha) uptake was observed in cells expressing hOAT1, hOAT2, hOAT3, hOAT4, hOCT1, and hOCT2. Prostaglandins F 50-53 solute carrier family 22 member 7 Homo sapiens 110-115 11907186-4 2002 A time- and dose-dependent increase in PGE(2) and PGF(2 alpha) uptake was observed in cells expressing hOAT1, hOAT2, hOAT3, hOAT4, hOCT1, and hOCT2. Prostaglandins F 50-53 solute carrier family 22 member 8 Homo sapiens 117-122 11907186-4 2002 A time- and dose-dependent increase in PGE(2) and PGF(2 alpha) uptake was observed in cells expressing hOAT1, hOAT2, hOAT3, hOAT4, hOCT1, and hOCT2. Prostaglandins F 50-53 solute carrier family 22 member 11 Homo sapiens 124-129 11907186-4 2002 A time- and dose-dependent increase in PGE(2) and PGF(2 alpha) uptake was observed in cells expressing hOAT1, hOAT2, hOAT3, hOAT4, hOCT1, and hOCT2. Prostaglandins F 50-53 solute carrier family 22 member 1 Homo sapiens 131-136 11907186-4 2002 A time- and dose-dependent increase in PGE(2) and PGF(2 alpha) uptake was observed in cells expressing hOAT1, hOAT2, hOAT3, hOAT4, hOCT1, and hOCT2. Prostaglandins F 50-53 POU class 2 homeobox 2 Homo sapiens 142-147 11907186-5 2002 The K(m) values of PGE(2) uptake by hOAT1, hOAT2, hOAT3, hOAT4, hOCT1, and hOCT2 were 970, 713, 345, 154, 657, and 28.9 nM, respectively, whereas those of PGF(2 alpha) uptake by hOAT1, hOAT3, hOAT4, hOCT1, and hOCT2 were 575, 1092, 692, 477, and 334 nM, respectively. Prostaglandins F 155-158 solute carrier family 22 member 6 Homo sapiens 36-41 12054910-8 2002 On the sub-placenta, GnRH had an initial inhibitory action on the outputs of PGF(2alpha) and 6-keto-PGF(1 alpha), which was then followed by a stimulation of the outputs of PGF(2 alpha) and, to a lesser extent, of PGE(2). Prostaglandins F 77-80 progonadoliberin-1 Cavia porcellus 21-25 12054910-8 2002 On the sub-placenta, GnRH had an initial inhibitory action on the outputs of PGF(2alpha) and 6-keto-PGF(1 alpha), which was then followed by a stimulation of the outputs of PGF(2 alpha) and, to a lesser extent, of PGE(2). Prostaglandins F 100-103 progonadoliberin-1 Cavia porcellus 21-25 12054911-1 2002 Prostaglandin E(2) 9-keto reductase (9-KPR) activity shifts reversibly PGE(2) into PGF(2 alpha) and may be responsible for the control of prostaglandins (PGs) levels in, among others, placental tissues. Prostaglandins F 83-86 carbonyl reductase [NADPH] 1 Bos taurus 0-35 12054911-1 2002 Prostaglandin E(2) 9-keto reductase (9-KPR) activity shifts reversibly PGE(2) into PGF(2 alpha) and may be responsible for the control of prostaglandins (PGs) levels in, among others, placental tissues. Prostaglandins F 83-86 carbonyl reductase [NADPH] 1 Bos taurus 37-42 12054913-1 2002 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) and endothelin-1 (ET-1) induce interleukin (IL)-6 through the activation of protein kinase C-dependent p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 26-41 mitogen-activated protein kinase 3 Mus musculus 167-170 12054913-1 2002 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) and endothelin-1 (ET-1) induce interleukin (IL)-6 through the activation of protein kinase C-dependent p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 26-41 cyclin-dependent kinase 20 Mus musculus 171-174 12054913-1 2002 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) and endothelin-1 (ET-1) induce interleukin (IL)-6 through the activation of protein kinase C-dependent p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 51-54 mitogen-activated protein kinase 3 Mus musculus 167-170 12054913-1 2002 We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) and endothelin-1 (ET-1) induce interleukin (IL)-6 through the activation of protein kinase C-dependent p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. Prostaglandins F 51-54 cyclin-dependent kinase 20 Mus musculus 171-174 12054913-3 2002 In the present study, we investigated the effect of IL-17 on the IL-6 synthesis stimulated by PGF(2alpha) in MC3T3-E1 cells. Prostaglandins F 94-97 interleukin 17A Mus musculus 52-57 12054913-3 2002 In the present study, we investigated the effect of IL-17 on the IL-6 synthesis stimulated by PGF(2alpha) in MC3T3-E1 cells. Prostaglandins F 94-97 interleukin 6 Mus musculus 65-69 12054913-4 2002 IL-17 significantly enhanced the PGF(2alpha)-induced IL-6 synthesis in a dose-dependent manner in the range between 0.1 and 10 ng/ml. Prostaglandins F 33-36 interleukin 17A Mus musculus 0-5 12054913-4 2002 IL-17 significantly enhanced the PGF(2alpha)-induced IL-6 synthesis in a dose-dependent manner in the range between 0.1 and 10 ng/ml. Prostaglandins F 33-36 interleukin 6 Mus musculus 53-57 12054913-6 2002 However, IL-17 hardly affected the phosphorylation of p44/p42 MAP kinase induced by PGF(2alpha) or ET-1. Prostaglandins F 84-87 mitogen-activated protein kinase 3 Mus musculus 54-57 12054913-6 2002 However, IL-17 hardly affected the phosphorylation of p44/p42 MAP kinase induced by PGF(2alpha) or ET-1. Prostaglandins F 84-87 cyclin-dependent kinase 20 Mus musculus 58-61 12054913-7 2002 These results strongly suggest that IL-17 enhances the IL-6 synthesis stimulated by PGF(2alpha) as well as ET-1 in osteoblasts, and that the effect is exerted at a point downstream from p44/p42 MAP kinase. Prostaglandins F 84-87 interleukin 17A Mus musculus 36-41 12054913-7 2002 These results strongly suggest that IL-17 enhances the IL-6 synthesis stimulated by PGF(2alpha) as well as ET-1 in osteoblasts, and that the effect is exerted at a point downstream from p44/p42 MAP kinase. Prostaglandins F 84-87 interleukin 6 Mus musculus 55-59 11870075-2 2002 We previously reported a decrease in luteal TIMP-1 within 15 min of prostaglandin F(2 alpha) (PGF(2 alpha))-induced luteolysis. Prostaglandins F 68-83 metalloproteinase inhibitor 1 Ovis aries 44-50 11870075-2 2002 We previously reported a decrease in luteal TIMP-1 within 15 min of prostaglandin F(2 alpha) (PGF(2 alpha))-induced luteolysis. Prostaglandins F 94-97 metalloproteinase inhibitor 1 Ovis aries 44-50 11870075-4 2002 The objectives of these experiments were to determine whether 1) PGF(2 alpha) affects expression of mRNA encoding fibrillar collagenases (MMP-1 and -13), gelatinases A and B (MMP-2 and -9), membrane type (mt)-1 MMP (MMP-14), stromelysin (MMP-3), and matrilysin (MMP-7), and 2) PGF(2 alpha) increases MMP activity during PGF(2 alpha)-induced luteolysis in sheep. Prostaglandins F 65-68 interstitial collagenase Ovis aries 138-151 11870075-4 2002 The objectives of these experiments were to determine whether 1) PGF(2 alpha) affects expression of mRNA encoding fibrillar collagenases (MMP-1 and -13), gelatinases A and B (MMP-2 and -9), membrane type (mt)-1 MMP (MMP-14), stromelysin (MMP-3), and matrilysin (MMP-7), and 2) PGF(2 alpha) increases MMP activity during PGF(2 alpha)-induced luteolysis in sheep. Prostaglandins F 65-68 72 kDa type IV collagenase Ovis aries 175-187 11870075-4 2002 The objectives of these experiments were to determine whether 1) PGF(2 alpha) affects expression of mRNA encoding fibrillar collagenases (MMP-1 and -13), gelatinases A and B (MMP-2 and -9), membrane type (mt)-1 MMP (MMP-14), stromelysin (MMP-3), and matrilysin (MMP-7), and 2) PGF(2 alpha) increases MMP activity during PGF(2 alpha)-induced luteolysis in sheep. Prostaglandins F 65-68 matrix metalloproteinase-14 Ovis aries 138-141 11870075-4 2002 The objectives of these experiments were to determine whether 1) PGF(2 alpha) affects expression of mRNA encoding fibrillar collagenases (MMP-1 and -13), gelatinases A and B (MMP-2 and -9), membrane type (mt)-1 MMP (MMP-14), stromelysin (MMP-3), and matrilysin (MMP-7), and 2) PGF(2 alpha) increases MMP activity during PGF(2 alpha)-induced luteolysis in sheep. Prostaglandins F 65-68 matrix metalloproteinase-14 Ovis aries 216-222 11870075-4 2002 The objectives of these experiments were to determine whether 1) PGF(2 alpha) affects expression of mRNA encoding fibrillar collagenases (MMP-1 and -13), gelatinases A and B (MMP-2 and -9), membrane type (mt)-1 MMP (MMP-14), stromelysin (MMP-3), and matrilysin (MMP-7), and 2) PGF(2 alpha) increases MMP activity during PGF(2 alpha)-induced luteolysis in sheep. Prostaglandins F 65-68 stromelysin-1 Ovis aries 238-243 11870075-4 2002 The objectives of these experiments were to determine whether 1) PGF(2 alpha) affects expression of mRNA encoding fibrillar collagenases (MMP-1 and -13), gelatinases A and B (MMP-2 and -9), membrane type (mt)-1 MMP (MMP-14), stromelysin (MMP-3), and matrilysin (MMP-7), and 2) PGF(2 alpha) increases MMP activity during PGF(2 alpha)-induced luteolysis in sheep. Prostaglandins F 65-68 MMP-7 Ovis aries 250-260 11870075-4 2002 The objectives of these experiments were to determine whether 1) PGF(2 alpha) affects expression of mRNA encoding fibrillar collagenases (MMP-1 and -13), gelatinases A and B (MMP-2 and -9), membrane type (mt)-1 MMP (MMP-14), stromelysin (MMP-3), and matrilysin (MMP-7), and 2) PGF(2 alpha) increases MMP activity during PGF(2 alpha)-induced luteolysis in sheep. Prostaglandins F 65-68 matrilysin Ovis aries 262-267 11870075-4 2002 The objectives of these experiments were to determine whether 1) PGF(2 alpha) affects expression of mRNA encoding fibrillar collagenases (MMP-1 and -13), gelatinases A and B (MMP-2 and -9), membrane type (mt)-1 MMP (MMP-14), stromelysin (MMP-3), and matrilysin (MMP-7), and 2) PGF(2 alpha) increases MMP activity during PGF(2 alpha)-induced luteolysis in sheep. Prostaglandins F 65-68 matrix metalloproteinase-14 Ovis aries 175-178 11870075-8 2002 Expression of MMP-14 mRNA increased significantly (P < 0.05) by 15 min post-PGF(2 alpha) and remained elevated through 48 h. MMP activity in luteal homogenates (following proenzyme activation and inactivation of inhibitors) was increased significantly (P < 0.05) by 15 min and remained elevated through 48 h post-PGF(2 alpha). Prostaglandins F 79-82 matrix metalloproteinase-14 Ovis aries 14-20 11870075-8 2002 Expression of MMP-14 mRNA increased significantly (P < 0.05) by 15 min post-PGF(2 alpha) and remained elevated through 48 h. MMP activity in luteal homogenates (following proenzyme activation and inactivation of inhibitors) was increased significantly (P < 0.05) by 15 min and remained elevated through 48 h post-PGF(2 alpha). Prostaglandins F 79-82 matrix metalloproteinase-14 Ovis aries 14-17 11870075-8 2002 Expression of MMP-14 mRNA increased significantly (P < 0.05) by 15 min post-PGF(2 alpha) and remained elevated through 48 h. MMP activity in luteal homogenates (following proenzyme activation and inactivation of inhibitors) was increased significantly (P < 0.05) by 15 min and remained elevated through 48 h post-PGF(2 alpha). Prostaglandins F 319-322 matrix metalloproteinase-14 Ovis aries 14-20 11870075-8 2002 Expression of MMP-14 mRNA increased significantly (P < 0.05) by 15 min post-PGF(2 alpha) and remained elevated through 48 h. MMP activity in luteal homogenates (following proenzyme activation and inactivation of inhibitors) was increased significantly (P < 0.05) by 15 min and remained elevated through 48 h post-PGF(2 alpha). Prostaglandins F 319-322 matrix metalloproteinase-14 Ovis aries 14-17 11870075-9 2002 MMP activity was localized (in situ zymography) to the pericellular area of various cell types in the 0-h group and was markedly increased by 30 min post-PGF(2 alpha). Prostaglandins F 154-157 matrix metalloproteinase-14 Ovis aries 0-3 11870075-10 2002 MMP mRNA expression and activity were significantly increased following PGF(2 alpha) treatment. Prostaglandins F 72-75 matrix metalloproteinase-14 Ovis aries 0-3 11719525-1 2002 We have previously demonstrated that prostaglandin F(2alpha) (PGF(2alpha)) induces a rapid and transient expression of Nur77 in luteal cells. Prostaglandins F 37-52 nuclear receptor subfamily 4 group A member 1 Homo sapiens 119-124 11719525-1 2002 We have previously demonstrated that prostaglandin F(2alpha) (PGF(2alpha)) induces a rapid and transient expression of Nur77 in luteal cells. Prostaglandins F 62-65 nuclear receptor subfamily 4 group A member 1 Homo sapiens 119-124 11719525-2 2002 We have shown that Nur77 plays an important role in ovarian physiology by mediating the PGF(2alpha) induction of 20alpha-HSD, a steroidogenic enzyme involved in the catabolism of progesterone. Prostaglandins F 88-91 nuclear receptor subfamily 4 group A member 1 Homo sapiens 19-24 11719525-2 2002 We have shown that Nur77 plays an important role in ovarian physiology by mediating the PGF(2alpha) induction of 20alpha-HSD, a steroidogenic enzyme involved in the catabolism of progesterone. Prostaglandins F 88-91 hydroxysteroid 17-beta dehydrogenase 2 Homo sapiens 113-124 11719525-3 2002 In this report we established, using luteinized granulosa cells, that PGF(2alpha) stimulates in vitro nur77 expression in a time- and dose-dependent manner. Prostaglandins F 70-73 nuclear receptor subfamily 4 group A member 1 Homo sapiens 102-107 11832489-7 2002 Finally, depletion of NOX1 mRNA in the cells transfected with ribozymes targeted for three independent cleavage sites on the mRNA sequence significantly reduced the PGF(2alpha)-induced increase in protein synthesis. Prostaglandins F 165-168 NADPH oxidase 1 Rattus norvegicus 22-26 11832489-8 2002 Taken together, these results suggest that hypertrophy of vascular smooth muscle cells caused by PGF(2alpha) is mediated by NOX1 induction and the resultant overproduction of O(2)(-) by NADPH oxidase. Prostaglandins F 97-100 NADPH oxidase 1 Rattus norvegicus 124-128 11841807-3 2002 Both basal PLA(2) activity and PG synthesis are sensitive to BEL and AACOCF3, respectively, inhibitors of calcium-independent PLA(2) (iPLA(2)) and cytosolic PLA(2) (cPLA(2)), while OPC, an inhibitor of soluble PLA(2) (sPLA(2)) only inhibited the hypoxia-induced AA release and PGF(2alpha) synthesis. Prostaglandins F 277-280 phospholipase A2 group IB Homo sapiens 11-17 11805196-7 2002 Both the COX-1 inhibitor SC-560 and the COX-2 inhibitor SC-236 suppressed the generation of PGE(2) and PGF(2alpha), particularly when combined, suggesting a role for both isozymes in the generation of prostaglandins in this model. Prostaglandins F 103-106 cytochrome c oxidase I, mitochondrial Rattus norvegicus 9-14 11805196-7 2002 Both the COX-1 inhibitor SC-560 and the COX-2 inhibitor SC-236 suppressed the generation of PGE(2) and PGF(2alpha), particularly when combined, suggesting a role for both isozymes in the generation of prostaglandins in this model. Prostaglandins F 103-106 cytochrome c oxidase II, mitochondrial Rattus norvegicus 40-45 11841807-3 2002 Both basal PLA(2) activity and PG synthesis are sensitive to BEL and AACOCF3, respectively, inhibitors of calcium-independent PLA(2) (iPLA(2)) and cytosolic PLA(2) (cPLA(2)), while OPC, an inhibitor of soluble PLA(2) (sPLA(2)) only inhibited the hypoxia-induced AA release and PGF(2alpha) synthesis. Prostaglandins F 277-280 phospholipase A2 group IVA Homo sapiens 165-172 11878817-3 2002 Affinities of M1, M2, latanoprost, acid of latanoprost, and PGF(2 alpha)to PGT molecule were measured using PGT-cDNA transfected HeLa cells by an isotopic influx assay. Prostaglandins F 60-63 solute carrier organic anion transporter family member 2A1 Homo sapiens 75-78 11774380-7 2002 In vitro, cox-2 expression in COCs was associated with increased concentrations of PGE(2) and PGF(2alpha) in the maturation medium. Prostaglandins F 94-97 cytochrome c oxidase subunit II Bos taurus 10-15 11717132-1 2001 Recent evidence in the cow suggests that endothelin-1 (ET-1) plays a role during prostaglandin (PG) F(2alpha)-induced luteal regression. Prostaglandins F 81-101 endothelin 1 Bos taurus 41-53 11719285-7 2001 The granulosa cells transfected to overexpress IGFBP-3 had an increase in IGF-I, PGF and PGE release, and a decrease in basal and hormone- or growth factor-induced accumulation of progesterone and oxytocin. Prostaglandins F 81-84 insulin like growth factor binding protein 3 Bos taurus 47-54 11719525-4 2002 Serial 5"-deletion of the nur77 promoter revealed that the necessary and sufficient elements for PGF(2alpha) induction of Nur77 promoter activity are located between the nucleotides -86 and -33 upstream of the transcription start site, this region containing two AP1 elements. Prostaglandins F 97-100 nuclear receptor subfamily 4 group A member 1 Homo sapiens 26-31 11719525-4 2002 Serial 5"-deletion of the nur77 promoter revealed that the necessary and sufficient elements for PGF(2alpha) induction of Nur77 promoter activity are located between the nucleotides -86 and -33 upstream of the transcription start site, this region containing two AP1 elements. Prostaglandins F 97-100 nuclear receptor subfamily 4 group A member 1 Homo sapiens 122-127 11719525-4 2002 Serial 5"-deletion of the nur77 promoter revealed that the necessary and sufficient elements for PGF(2alpha) induction of Nur77 promoter activity are located between the nucleotides -86 and -33 upstream of the transcription start site, this region containing two AP1 elements. Prostaglandins F 97-100 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 263-266 11719525-6 2002 However, mutation of the AP1 sites as well as a dominant-negative JunD abolished nur77 induction by PGF(2alpha). Prostaglandins F 100-103 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 25-28 11719525-6 2002 However, mutation of the AP1 sites as well as a dominant-negative JunD abolished nur77 induction by PGF(2alpha). Prostaglandins F 100-103 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 66-70 11719525-6 2002 However, mutation of the AP1 sites as well as a dominant-negative JunD abolished nur77 induction by PGF(2alpha). Prostaglandins F 100-103 nuclear receptor subfamily 4 group A member 1 Homo sapiens 81-86 11719525-7 2002 PGF(2alpha) induces phosphorylation of JunD bound to the nur77 promoter. Prostaglandins F 0-3 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 39-43 11719525-7 2002 PGF(2alpha) induces phosphorylation of JunD bound to the nur77 promoter. Prostaglandins F 0-3 nuclear receptor subfamily 4 group A member 1 Homo sapiens 57-62 11719525-9 2002 PGF(2alpha)-induced ERK1/2 phosphorylation was prevented by calcium/calmodulin inhibitors. Prostaglandins F 0-3 mitogen-activated protein kinase 3 Homo sapiens 20-26 11719525-10 2002 We conclude that activation of JunD through a calmodulim-dependent activation of ERK1/2 mediates nur77 induction by PGF(2alpha). Prostaglandins F 116-119 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 31-35 11719525-10 2002 We conclude that activation of JunD through a calmodulim-dependent activation of ERK1/2 mediates nur77 induction by PGF(2alpha). Prostaglandins F 116-119 mitogen-activated protein kinase 3 Homo sapiens 81-87 11719525-10 2002 We conclude that activation of JunD through a calmodulim-dependent activation of ERK1/2 mediates nur77 induction by PGF(2alpha). Prostaglandins F 116-119 nuclear receptor subfamily 4 group A member 1 Homo sapiens 97-102 11713223-1 2001 Endothelin-1 (ET)-1 within the corpus luteum (CL) is rapidly up-regulated during natural or PGF(2 alpha)-induced luteolysis; however, such an increase was not observed at early luteal stage, when the CL is refractory to PGF(2 alpha). Prostaglandins F 92-95 endothelin 1 Bos taurus 0-19 11713223-1 2001 Endothelin-1 (ET)-1 within the corpus luteum (CL) is rapidly up-regulated during natural or PGF(2 alpha)-induced luteolysis; however, such an increase was not observed at early luteal stage, when the CL is refractory to PGF(2 alpha). Prostaglandins F 220-223 endothelin 1 Bos taurus 0-19 11713223-9 2001 Low ECE-1 levels during the early luteal phase, restricting the production of active ET-1, may explain why the immature CL is able to withstand PGF(2 alpha)-induced luteolysis. Prostaglandins F 144-147 endothelin converting enzyme 1 Bos taurus 4-9 11713223-9 2001 Low ECE-1 levels during the early luteal phase, restricting the production of active ET-1, may explain why the immature CL is able to withstand PGF(2 alpha)-induced luteolysis. Prostaglandins F 144-147 endothelin 1 Bos taurus 85-89 11717132-1 2001 Recent evidence in the cow suggests that endothelin-1 (ET-1) plays a role during prostaglandin (PG) F(2alpha)-induced luteal regression. Prostaglandins F 81-101 endothelin 1 Bos taurus 55-59 11717132-8 2001 The ET-1 was the most likely component of the endothelin system target for PGF(2alpha) regulation during the midluteal phase. Prostaglandins F 75-78 endothelin 1 Bos taurus 4-8 11717132-10 2001 A practical application of this observation is that it may be possible to target the ET-1 gene as a way to manipulate the luteolytic action of PGF(2alpha). Prostaglandins F 143-146 endothelin 1 Bos taurus 85-89 11514344-8 2001 Both Ang II and ANP increased PGE(2) and PGF(2alpha) release. Prostaglandins F 41-44 natriuretic peptide A Bos taurus 16-19 11719597-5 2001 PGF(2alpha) caused a 2.4- and 1.9-fold increase in the production of MMP-2 and MMP-9 in the decidua, respectively (P < 0.05), and an 11.3-fold increase of the active form of MMP-2 (62 kDa) which could hardly be detected in basal culture conditions (P < 0.01). Prostaglandins F 0-3 matrix metallopeptidase 2 Homo sapiens 69-74 11719597-5 2001 PGF(2alpha) caused a 2.4- and 1.9-fold increase in the production of MMP-2 and MMP-9 in the decidua, respectively (P < 0.05), and an 11.3-fold increase of the active form of MMP-2 (62 kDa) which could hardly be detected in basal culture conditions (P < 0.01). Prostaglandins F 0-3 matrix metallopeptidase 9 Homo sapiens 79-84 11719597-5 2001 PGF(2alpha) caused a 2.4- and 1.9-fold increase in the production of MMP-2 and MMP-9 in the decidua, respectively (P < 0.05), and an 11.3-fold increase of the active form of MMP-2 (62 kDa) which could hardly be detected in basal culture conditions (P < 0.01). Prostaglandins F 0-3 matrix metallopeptidase 2 Homo sapiens 177-182 11719597-6 2001 PGF(2alpha) decreased TIMP-1 production by 70% in the decidua. Prostaglandins F 0-3 TIMP metallopeptidase inhibitor 1 Homo sapiens 22-28 11673276-1 2001 There is positive feedback pathway in the ovine large luteal cell, such that prostaglandin (PG) F(2 alpha) stimulation induces intraluteal PGF(2 alpha) production as the result of induction of one of the rate-limiting enzymes in PG production, cyclooxygenase-2 (Cox-2). Prostaglandins F 139-142 prostaglandin-endoperoxide synthase 2 Homo sapiens 244-260 11673276-1 2001 There is positive feedback pathway in the ovine large luteal cell, such that prostaglandin (PG) F(2 alpha) stimulation induces intraluteal PGF(2 alpha) production as the result of induction of one of the rate-limiting enzymes in PG production, cyclooxygenase-2 (Cox-2). Prostaglandins F 139-142 prostaglandin-endoperoxide synthase 2 Homo sapiens 262-267 11673276-3 2001 In transient transfection assays, Cox-2 promoter was rapidly induced (4 h) by phorbol didecanoate (a protein kinase [PK] C activator), ionomycin, and cloprostenol (PGF(2 alpha) analogue), with a peak induction at 12 h. Cloprostenol-mediated promoter activation was not blocked by inhibition of various second messenger systems, including PKA, calcium calmodulin kinase II, or mitogen-activated protein kinases. Prostaglandins F 164-167 prostaglandin-endoperoxide synthase 2 Homo sapiens 34-39 11682450-4 2001 In arteries contracted with prostaglandin F(2 alpha) (2.5 - 10 microM), relaxation evoked by ACh (0.01 - 3 microM) was abolished by a combination of charybdotoxin (ChTX, 0.1 microM) plus apamin (Apa, 0.1 microM) and was inhibited by 68+/-6% (n=6) by 4-aminopyridine (4-AP, 5 mM). Prostaglandins F 28-43 glutamyl aminopeptidase Rattus norvegicus 195-198 11700032-4 2001 In human primary cultured decidual cells, a p38 inhibitor, SB202190, significantly inhibited both prostaglandin F(2alpha) production and COX-2 expression induced by stimulation with IL-1beta. Prostaglandins F 98-113 mitogen-activated protein kinase 14 Homo sapiens 44-47 11700032-4 2001 In human primary cultured decidual cells, a p38 inhibitor, SB202190, significantly inhibited both prostaglandin F(2alpha) production and COX-2 expression induced by stimulation with IL-1beta. Prostaglandins F 98-113 interleukin 1 beta Homo sapiens 182-190 11483084-8 2001 CONCLUSIONS: Treatment of monkey eyes with PGF(2 alpha)-IE induces elevation of MMP-1, MMP-2, and MMP-3 in tissues of the uveoscleral outflow pathway. Prostaglandins F 43-46 interstitial collagenase Macaca fascicularis 80-85 11517196-3 2001 In this investigation, we have found twelve more genes that are inversely regulated by PRL and PGF(2 alpha). Prostaglandins F 95-98 prolactin Rattus norvegicus 87-90 11517196-4 2001 In addition to 20 alpha-HSD, PGF(2 alpha) stimulated and PRL inhibited PGF(2 alpha)-receptor, phospholipase C delta(1) and TGF beta(1) expression. Prostaglandins F 29-32 phospholipase C, delta 1 Rattus norvegicus 94-118 11517196-4 2001 In addition to 20 alpha-HSD, PGF(2 alpha) stimulated and PRL inhibited PGF(2 alpha)-receptor, phospholipase C delta(1) and TGF beta(1) expression. Prostaglandins F 29-32 transforming growth factor, beta 1 Rattus norvegicus 123-134 11517196-5 2001 In contrast PRL stimulated and PGF(2 alpha) inhibited the LH receptor, 11 beta-HSD2, sterol carrier protein 2, mitochondrial glutathione S-transferase (GST), GST mu(2), inhibitory DNA-binding proteins 1, 2, and 3, and calcium binding protein 2. Prostaglandins F 31-34 sterol carrier protein 2 Rattus norvegicus 85-109 11517196-5 2001 In contrast PRL stimulated and PGF(2 alpha) inhibited the LH receptor, 11 beta-HSD2, sterol carrier protein 2, mitochondrial glutathione S-transferase (GST), GST mu(2), inhibitory DNA-binding proteins 1, 2, and 3, and calcium binding protein 2. Prostaglandins F 31-34 hematopoietic prostaglandin D synthase Rattus norvegicus 125-150 11517196-5 2001 In contrast PRL stimulated and PGF(2 alpha) inhibited the LH receptor, 11 beta-HSD2, sterol carrier protein 2, mitochondrial glutathione S-transferase (GST), GST mu(2), inhibitory DNA-binding proteins 1, 2, and 3, and calcium binding protein 2. Prostaglandins F 31-34 hematopoietic prostaglandin D synthase Rattus norvegicus 152-155 11517196-5 2001 In contrast PRL stimulated and PGF(2 alpha) inhibited the LH receptor, 11 beta-HSD2, sterol carrier protein 2, mitochondrial glutathione S-transferase (GST), GST mu(2), inhibitory DNA-binding proteins 1, 2, and 3, and calcium binding protein 2. Prostaglandins F 31-34 hematopoietic prostaglandin D synthase Rattus norvegicus 158-161 11517196-5 2001 In contrast PRL stimulated and PGF(2 alpha) inhibited the LH receptor, 11 beta-HSD2, sterol carrier protein 2, mitochondrial glutathione S-transferase (GST), GST mu(2), inhibitory DNA-binding proteins 1, 2, and 3, and calcium binding protein 2. Prostaglandins F 31-34 calcium binding protein 2 Rattus norvegicus 218-243 11517196-7 2001 PGF(2 alpha) stimulated the expression of genes involved in cell signaling such as cell adhesion kinase-beta, ERK3, FRA2, IL-2 receptor, and 14-3-3 proteins. Prostaglandins F 0-3 mitogen-activated protein kinase 6 Rattus norvegicus 110-114 11517196-7 2001 PGF(2 alpha) stimulated the expression of genes involved in cell signaling such as cell adhesion kinase-beta, ERK3, FRA2, IL-2 receptor, and 14-3-3 proteins. Prostaglandins F 0-3 FOS like 2, AP-1 transcription factor subunit Rattus norvegicus 116-120 11517196-8 2001 PGF(2 alpha) also up-regulated the expression of the sodium channel beta(1), Na/K ATPase, annexin IV, GST7pi, and P450 reductase. Prostaglandins F 0-3 annexin A4 Rattus norvegicus 90-100 11517196-9 2001 In contrast PGF(2 alpha) inhibited the expression of two genes involved in cell cycle: cyclin D2 and retinoblastoma related protein (Rb2/p130). Prostaglandins F 12-15 cyclin D2 Rattus norvegicus 87-96 11517196-9 2001 In contrast PGF(2 alpha) inhibited the expression of two genes involved in cell cycle: cyclin D2 and retinoblastoma related protein (Rb2/p130). Prostaglandins F 12-15 RB transcriptional corepressor like 2 Rattus norvegicus 133-142 11517196-13 2001 In conclusion, this investigation has revealed a "yin-yang" relationship between PRL and PGF(2 alpha) in regulating certain critical genes in the rodent CL, and has demonstrated novel regulation by these factors of other important genes involved in luteal function. Prostaglandins F 89-92 prolactin Rattus norvegicus 81-84 11483084-8 2001 CONCLUSIONS: Treatment of monkey eyes with PGF(2 alpha)-IE induces elevation of MMP-1, MMP-2, and MMP-3 in tissues of the uveoscleral outflow pathway. Prostaglandins F 43-46 72 kDa type IV collagenase Macaca fascicularis 87-92 11483084-8 2001 CONCLUSIONS: Treatment of monkey eyes with PGF(2 alpha)-IE induces elevation of MMP-1, MMP-2, and MMP-3 in tissues of the uveoscleral outflow pathway. Prostaglandins F 43-46 stromelysin-1 Macaca fascicularis 98-103 11470756-10 2001 PGE(2) or PGF(2alpha) increased expression of TGFalpha and DNA replication in GSTp(-) cells but not in GSTp(+) cells. Prostaglandins F 10-13 transforming growth factor alpha Rattus norvegicus 46-54 11369587-0 2001 Endothelin-1 mediates prostaglandin F(2alpha)-induced luteal regression in the ewe. Prostaglandins F 22-37 endothelin 1 Bos taurus 0-12 11369587-4 2001 Administration of a luteolytic dose of prostaglandin F(2alpha) (PGF(2alpha)) rapidly stimulated gene expression for ET-1 in ovine corpora lutea (CL) collected at midcycle. Prostaglandins F 39-54 endothelin 1 Bos taurus 116-120 11369587-4 2001 Administration of a luteolytic dose of prostaglandin F(2alpha) (PGF(2alpha)) rapidly stimulated gene expression for ET-1 in ovine corpora lutea (CL) collected at midcycle. Prostaglandins F 64-67 endothelin 1 Bos taurus 116-120 11369587-9 2001 These data complement and extend previously published reports in the bovine CL and are the strongest evidence presented to date in support of a role for ET-1 in PGF(2alpha)-mediated luteal function in domestic ruminants. Prostaglandins F 161-164 endothelin 1 Bos taurus 153-157 11369595-2 2001 Therefore, the objective of this study was to determine if oxytocin acted in an autocrine manner on luminal epithelial cells to stimulate prostaglandin (PG)F(2alpha) secretion. Prostaglandins F 138-157 oxytocin/neurophysin I prepropeptide Sus scrofa 59-67 11369595-3 2001 Treatment of endometrial explants or enriched luminal epithelial cells with OT antagonist L-366,948 decreased (P < 0.05) basal secretion of PGF(2alpha). Prostaglandins F 143-146 oxytocin/neurophysin I prepropeptide Sus scrofa 76-78 11369595-4 2001 Oxytocin increased (P < 0.01) PGF(2alpha) secretion from luminal epithelial cells that were pretreated with 1:5000 or 1:500 OT antiserum for 3 h to immunoneutralize endogenously secreted OT. Prostaglandins F 33-36 oxytocin/neurophysin I prepropeptide Sus scrofa 0-8 11356928-6 2001 Consistent with the increased expression of COX-2, BBMEC monolayers exposed to TNF-alpha had significantly greater secretion and release of prostaglandin E(2) (PGE(2)) and prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 172-187 cytochrome c oxidase subunit II Bos taurus 44-49 11356928-6 2001 Consistent with the increased expression of COX-2, BBMEC monolayers exposed to TNF-alpha had significantly greater secretion and release of prostaglandin E(2) (PGE(2)) and prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 172-187 tumor necrosis factor Bos taurus 79-88 11356928-6 2001 Consistent with the increased expression of COX-2, BBMEC monolayers exposed to TNF-alpha had significantly greater secretion and release of prostaglandin E(2) (PGE(2)) and prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 197-200 cytochrome c oxidase subunit II Bos taurus 44-49 11356928-6 2001 Consistent with the increased expression of COX-2, BBMEC monolayers exposed to TNF-alpha had significantly greater secretion and release of prostaglandin E(2) (PGE(2)) and prostaglandin F(2alpha) (PGF(2alpha)). Prostaglandins F 197-200 tumor necrosis factor Bos taurus 79-88 11447235-11 2001 Minimal 15-hydroxyprostaglandin dehydrogenase oxidation of PGF(2 alpha)-G was observed. Prostaglandins F 59-62 carbonyl reductase 1 Homo sapiens 8-45 11840344-7 2001 Furthermore, pre-incubation with COX-2 inhibitors, followed by supplementation with PGD2, PGE2 or PGF 2alpha, increases uPA, MMP-9 and MMP-1 levels in corneas similar to and in some cases greater than that produced by cPAF treatment alone. Prostaglandins F 98-101 plasminogen activator, urokinase Homo sapiens 120-123 11840344-7 2001 Furthermore, pre-incubation with COX-2 inhibitors, followed by supplementation with PGD2, PGE2 or PGF 2alpha, increases uPA, MMP-9 and MMP-1 levels in corneas similar to and in some cases greater than that produced by cPAF treatment alone. Prostaglandins F 98-101 matrix metallopeptidase 9 Homo sapiens 125-130 11840344-7 2001 Furthermore, pre-incubation with COX-2 inhibitors, followed by supplementation with PGD2, PGE2 or PGF 2alpha, increases uPA, MMP-9 and MMP-1 levels in corneas similar to and in some cases greater than that produced by cPAF treatment alone. Prostaglandins F 98-101 matrix metallopeptidase 1 Homo sapiens 135-140 11545622-0 2001 Angiotensin II stimulates PGF(2 alpha)release in cultured neonatal rat ventricular myocytes via L-type calcium channels. Prostaglandins F 26-29 angiotensinogen Rattus norvegicus 0-14 11545622-1 2001 Angiotensin II (Ang II) has been shown to cause Prostaglandin F(2 alpha)(PGF(2 alpha)) release in neonatal rat ventricular myocytes and smooth muscle cells. Prostaglandins F 48-63 angiotensinogen Rattus norvegicus 0-22 11545622-1 2001 Angiotensin II (Ang II) has been shown to cause Prostaglandin F(2 alpha)(PGF(2 alpha)) release in neonatal rat ventricular myocytes and smooth muscle cells. Prostaglandins F 73-76 angiotensinogen Rattus norvegicus 0-22 11545622-3 2001 We used neonatal rat ventricular myocytes to investigate the role of calcium in maintenance of Ang II-induced PGF(2 alpha)release. Prostaglandins F 110-113 angiotensinogen Rattus norvegicus 95-101 11545622-5 2001 Ang II-induced PGF(2 alpha)release. Prostaglandins F 15-18 angiotensinogen Rattus norvegicus 0-6 11545622-8 2001 These results strongly suggest that Ang II-induced PGF(2 alpha)release in neonatal rat ventricular myocytes is maintained, at least in part, via increase in extracellular calcium influx. Prostaglandins F 51-54 angiotensinogen Rattus norvegicus 36-42 11467975-8 2001 Treatment with PGF(2alpha) (100 nmol l(-1)) reduced forskolin-induced expression of PGF(2alpha) receptor mRNA on days 4, 7 and 10, but not on day 1 of culture (n = 3). Prostaglandins F 15-18 prostaglandin F receptor Bos taurus 84-104 11467975-10 2001 In contrast, PGF(2alpha) significantly increased PGHS-2 mRNA expression in granulosa cells primed with forskolin for 7 or 10 days. Prostaglandins F 13-16 prostaglandin-endoperoxide synthase 2 Bos taurus 49-55 11467975-12 2001 Granulosa cells become PGF(2alpha)-responsive soon after expression of PGF(2alpha) receptor, whereas further differentiation is required before PGF(2alpha) induces PGHS-2 mRNA upregulation. Prostaglandins F 23-26 prostaglandin F receptor Bos taurus 71-91 11416007-1 2001 Interferon-tau (IFNtau), the ruminant pregnancy recognition signal, inhibits transcription of the estrogen receptor alpha (ERalpha) gene in the endometrial lumenal epithelium of the sheep uterus, thereby abrogating production of luteolytic PGF(2alpha) pulses. Prostaglandins F 240-243 estrogen receptor Ovis aries 98-121 11431442-0 2001 Reduced TIGR/myocilin protein in the monkey ciliary muscle after topical prostaglandin F(2alpha) treatment. Prostaglandins F 73-88 myocilin Macaca fascicularis 8-12 11431442-0 2001 Reduced TIGR/myocilin protein in the monkey ciliary muscle after topical prostaglandin F(2alpha) treatment. Prostaglandins F 73-88 myocilin Macaca fascicularis 13-21 11431442-18 2001 Moreover, IOP-lowering topical PGF(2alpha)-IE treatment decreases the amount of TIGR protein in the ciliary muscle. Prostaglandins F 31-34 myocilin Macaca fascicularis 80-84 11487303-3 2001 Results indicate that HSVECs while under resting conditions produce mainly prostaglandin F(2alpha)(PGF(2alpha)). Prostaglandins F 75-90 placental growth factor Homo sapiens 99-102 11470756-10 2001 PGE(2) or PGF(2alpha) increased expression of TGFalpha and DNA replication in GSTp(-) cells but not in GSTp(+) cells. Prostaglandins F 10-13 glutathione S-transferase pi 1 Rattus norvegicus 78-82 11350048-7 2001 In these cells, an increase in cytosolic free Ca2+ concentration ([Ca2+]i) elicited by a known physiological stimulus, PGF(2alpha), was accompanied by a 40% decrease in the level of 11beta-HSD2 activity. Prostaglandins F 119-122 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 182-193 11373177-8 2001 Concentrations of mRNA for steroidogenic acute regulatory protein, FP receptor, 3beta-hydroxysteroid dehydrogenase, cytosolic phospholipase A(2) and LH receptor were decreased at 4.0 h after PGF(2alpha) injection. Prostaglandins F 191-194 steroidogenic acute regulatory protein Bos taurus 27-65 11373177-9 2001 In contrast, PGF(2alpha) increased mRNA concentrations for prostaglandin G/H synthase-2, monocyte chemoattractant protein-1 and c-fos but the time course differed for induction of these mRNAs. Prostaglandins F 13-16 prostaglandin-endoperoxide synthase 2 Bos taurus 59-87 11373177-9 2001 In contrast, PGF(2alpha) increased mRNA concentrations for prostaglandin G/H synthase-2, monocyte chemoattractant protein-1 and c-fos but the time course differed for induction of these mRNAs. Prostaglandins F 13-16 C-C motif chemokine 2 Bos taurus 89-123 11350048-8 2001 Furthermore, the PGF(2alpha)-induced inhibition of 11beta-HSD2 activity was abrogated when increases in [Ca2+]i were blocked with the intracellular Ca2+ chelator, BAPTA. Prostaglandins F 17-20 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 51-62 11311050-9 2001 We conclude from these results that in CISM cells PGF(2alpha)-induced cPLA(2)phosphorylation and AA release is mediated through p38 MAP kinase, but not through p42/p44 MAP kinases, whereas that of CCh is mediated through both p38 MAP kinase and p42/p44 MAP kinases. Prostaglandins F 50-53 mitogen-activated protein kinase 14 Homo sapiens 128-131 11311050-5 2001 We found that: (a) PGF(2alpha)and CCh increased p38 MAP kinase activity by 197 and 215%, respectively, and increased p42/p44 MAP kinase activity by 200 and 125%, respectively. Prostaglandins F 19-22 mitogen-activated protein kinase 14 Homo sapiens 48-51 11311050-9 2001 We conclude from these results that in CISM cells PGF(2alpha)-induced cPLA(2)phosphorylation and AA release is mediated through p38 MAP kinase, but not through p42/p44 MAP kinases, whereas that of CCh is mediated through both p38 MAP kinase and p42/p44 MAP kinases. Prostaglandins F 50-53 mitogen-activated protein kinase 14 Homo sapiens 226-229 11311050-5 2001 We found that: (a) PGF(2alpha)and CCh increased p38 MAP kinase activity by 197 and 215%, respectively, and increased p42/p44 MAP kinase activity by 200 and 125%, respectively. Prostaglandins F 19-22 cyclin dependent kinase 20 Homo sapiens 117-120 11311050-9 2001 We conclude from these results that in CISM cells PGF(2alpha)-induced cPLA(2)phosphorylation and AA release is mediated through p38 MAP kinase, but not through p42/p44 MAP kinases, whereas that of CCh is mediated through both p38 MAP kinase and p42/p44 MAP kinases. Prostaglandins F 50-53 cyclin dependent kinase 20 Homo sapiens 245-248 11311050-5 2001 We found that: (a) PGF(2alpha)and CCh increased p38 MAP kinase activity by 197 and 215%, respectively, and increased p42/p44 MAP kinase activity by 200 and 125%, respectively. Prostaglandins F 19-22 interferon induced protein 44 Homo sapiens 121-124 11311050-9 2001 We conclude from these results that in CISM cells PGF(2alpha)-induced cPLA(2)phosphorylation and AA release is mediated through p38 MAP kinase, but not through p42/p44 MAP kinases, whereas that of CCh is mediated through both p38 MAP kinase and p42/p44 MAP kinases. Prostaglandins F 50-53 interferon induced protein 44 Homo sapiens 249-252 11311050-6 2001 (b) SB202190, a p38 MAP kinase specific inhibitor, inhibited PGF(2alpha)- and CCh-induced cPLA(2)phosphorylation by 92 and 85%, respectively, and AA release by 62 and 78%, respectively. Prostaglandins F 61-64 mitogen-activated protein kinase 14 Homo sapiens 16-19 11329059-7 2001 Transplantation of wild-type bone marrow rescued the impaired angiogenesis and collateral growth in Pgf-/- mice, indicating that PlGF might have contributed to vessel growth in the adult by mobilizing bone-marrow-derived cells. Prostaglandins F 100-103 placental growth factor Mus musculus 129-133 11331663-6 2001 On day 8, PGF(2alpha) induced FP and PGHS-2 expression and at the same time decreased LH receptor expression, resulting in inhibition of progesterone output by GLC. Prostaglandins F 10-13 prostaglandin-endoperoxide synthase 2 Homo sapiens 37-43 11331663-6 2001 On day 8, PGF(2alpha) induced FP and PGHS-2 expression and at the same time decreased LH receptor expression, resulting in inhibition of progesterone output by GLC. Prostaglandins F 10-13 luteinizing hormone/choriogonadotropin receptor Homo sapiens 86-97 11278257-5 2001 We now show that acute treatment of FP(B)-expressing cells with PGF(2alpha) leads to a subcellular reorganization of beta-catenin, a decrease in the phosphorylation of cytoplasmic beta-catenin, and persistent stimulation of Tcf/Lef-mediated transcriptional activation. Prostaglandins F 64-67 catenin beta 1 Homo sapiens 180-192 11278257-5 2001 We now show that acute treatment of FP(B)-expressing cells with PGF(2alpha) leads to a subcellular reorganization of beta-catenin, a decrease in the phosphorylation of cytoplasmic beta-catenin, and persistent stimulation of Tcf/Lef-mediated transcriptional activation. Prostaglandins F 64-67 hepatocyte nuclear factor 4 alpha Homo sapiens 224-227 11278257-5 2001 We now show that acute treatment of FP(B)-expressing cells with PGF(2alpha) leads to a subcellular reorganization of beta-catenin, a decrease in the phosphorylation of cytoplasmic beta-catenin, and persistent stimulation of Tcf/Lef-mediated transcriptional activation. Prostaglandins F 64-67 catenin beta 1 Homo sapiens 117-129 11259248-5 2001 Treatment with PGF(2alpha) decreased FPr mRNA expression in luteal cells in most species that have been studied. Prostaglandins F 15-18 formyl peptide receptor 1 Homo sapiens 37-40 11259248-6 2001 Key amino acids have been suggested to be critical for binding of FPr to PGF(2alpha) based on three-dimensional modeling and comparisons with other G-protein-coupled receptors. Prostaglandins F 73-76 formyl peptide receptor 1 Homo sapiens 66-69 11259248-7 2001 Moieties of the PGF(2alpha) molecule that are essential for binding or specificity of binding to the FPr have been identified by radioreceptor binding studies. Prostaglandins F 16-19 formyl peptide receptor 1 Homo sapiens 101-104 11250644-9 2001 We further conclude that in the oestrogen-dominated rat myometrium the relaxing effect of beta(2)-adrenoceptor stimulation involves attenuation of both prostaglandin synthesis and PGF(2alpha)-R expression. Prostaglandins F 180-183 adrenoceptor beta 2 Rattus norvegicus 90-110 11297615-2 2001 We have previously shown that the expression of cyclooxygenase-2 and the receptor for PGF(2 alpha) are expressed in periovulatory human granulosa cells and upregulated by gonadotropins and cytokines in cultured human ovarian granulosa-luteal (GL) cells. Prostaglandins F 86-89 prostaglandin-endoperoxide synthase 2 Homo sapiens 48-64 11277881-3 2001 The aim of this study was to determine whether arginine- or lysine-vasopressin would activate phospholipase C, increase intracellular calcium concentration [Ca(2+)](i) and stimulate PGF(2alpha) production in enriched cultures of stromal, glandular epithelial and luminal epithelial cells from pig endometrium. Prostaglandins F 182-185 vasopressin Sus scrofa 67-78 11277881-8 2001 Activity of phospholipase C, [Ca(2+)](i) and PGF(2alpha) release were also increased (P < 0.05) by arginine-vasopressin in stromal cells, but the responses were less (P < 0.01) than those induced by oxytocin. Prostaglandins F 45-48 vasopressin Sus scrofa 111-122 11277883-14 2001 As western blotting of ovarian homogenates obtained from PGF(2alpha)-injected rats increased inducible NOS (iNOS) content, it is concluded that PGF(2alpha) enhances both activity and synthesis of NO in rat ovarian tissues during luteolysis. Prostaglandins F 57-60 nitric oxide synthase 2 Rattus norvegicus 108-112 11277883-14 2001 As western blotting of ovarian homogenates obtained from PGF(2alpha)-injected rats increased inducible NOS (iNOS) content, it is concluded that PGF(2alpha) enhances both activity and synthesis of NO in rat ovarian tissues during luteolysis. Prostaglandins F 144-147 nitric oxide synthase 2 Rattus norvegicus 108-112 11230325-8 2001 The ET-1-induced enhancement of PGF(2alpha) contraction was inhibited by Go6976 (10(-6) mol/L), an inhibitor of Ca(2+)-dependent PKC isoforms. Prostaglandins F 32-35 protein kinase C delta Homo sapiens 129-132 11241181-12 2001 In endometrial samples collected in the late luteal phase, IL-1alpha, -2 and -6 all inhibited OTR mRNA expression, but IL-1alpha and -2 both stimulated PGF(2alpha) production. Prostaglandins F 152-155 interleukin 1 alpha Bos taurus 119-135 11241181-17 2001 IL-I and -2 and LPS are therefore unlikely to initiate luteolysis but may cause raised production of PGF(2alpha) during uterine infection. Prostaglandins F 101-104 interleukin 2 Bos taurus 0-11 11159370-1 2001 Trophoblastic bovine interferon-tau (bIFN-tau) suppresses luteolytic pulses of endometrial prostaglandin F(2alpha) (PGF(2alpha)) at the time of maternal recognition of pregnancy. Prostaglandins F 91-106 interferon tau-2 Bos taurus 21-35 11159370-1 2001 Trophoblastic bovine interferon-tau (bIFN-tau) suppresses luteolytic pulses of endometrial prostaglandin F(2alpha) (PGF(2alpha)) at the time of maternal recognition of pregnancy. Prostaglandins F 116-119 interferon tau-2 Bos taurus 21-35 11257454-5 2001 PGF(2)alpha suppressed GPDH activity and did not increase the expression of GLUT1 protein in 3T3-L1 cells treated with DEX, IBMX, and insulin. Prostaglandins F 0-3 glycerol phosphate dehydrogenase 2, mitochondrial Mus musculus 23-27 11230325-6 2001 Pretreatment with ET-1 (10 pmol/L) for 10 minutes enhanced cell contraction to PGF(2alpha) (35%) with no additional increase in [Ca(2+)](i) (112+/-8 nmol/L). Prostaglandins F 79-82 endothelin 1 Homo sapiens 18-22 11230325-7 2001 Direct activation of PKC by phorbol 12,13-dibutyrate (PDBu, 10(-7) mol/L) caused cell contraction (10%) and enhanced PGF(2alpha) contraction (33%) with no additional increase in [Ca(2+)](i) (115+/-7 nmol/L). Prostaglandins F 117-120 protein kinase C delta Homo sapiens 21-24 11259776-7 2001 Conversely, PGF(2 alpha)- and AMPA-induced allodynia were observed in GluR epsilon 1(-/-) mice, but not in GluR epsilon 4(-/-) mice. Prostaglandins F 12-15 glutamate receptor, ionotropic, NMDA2A (epsilon 1) Mus musculus 70-84 11230325-14 2001 In tissues pretreated with ET-1 or PDBu, PGF(2alpha) caused additional increases in alpha-PKC activity. Prostaglandins F 41-44 endothelin 1 Homo sapiens 27-31 11230325-14 2001 In tissues pretreated with ET-1 or PDBu, PGF(2alpha) caused additional increases in alpha-PKC activity. Prostaglandins F 41-44 protein kinase C delta Homo sapiens 90-93 11230325-15 2001 Thus, the enhancement of PGF(2alpha)-induced coronary smooth muscle contraction by physiological concentrations of ET-1 involves activation and translocation of alpha-PKC in addition to delta- and epsilon-PKC isoforms, and this may represent one possible cellular mechanism by which ET-1 could enhance coronary vasoconstriction to vasoactive eicosanoids in coronary vasospasm. Prostaglandins F 25-28 endothelin 1 Homo sapiens 115-119 11230325-15 2001 Thus, the enhancement of PGF(2alpha)-induced coronary smooth muscle contraction by physiological concentrations of ET-1 involves activation and translocation of alpha-PKC in addition to delta- and epsilon-PKC isoforms, and this may represent one possible cellular mechanism by which ET-1 could enhance coronary vasoconstriction to vasoactive eicosanoids in coronary vasospasm. Prostaglandins F 25-28 protein kinase C delta Homo sapiens 186-217 11230325-15 2001 Thus, the enhancement of PGF(2alpha)-induced coronary smooth muscle contraction by physiological concentrations of ET-1 involves activation and translocation of alpha-PKC in addition to delta- and epsilon-PKC isoforms, and this may represent one possible cellular mechanism by which ET-1 could enhance coronary vasoconstriction to vasoactive eicosanoids in coronary vasospasm. Prostaglandins F 25-28 endothelin 1 Homo sapiens 283-287 11158051-0 2001 Endothelins enhance prostaglandin (PGE(2) and PGF(2alpha)) biosynthesis and release by human luteal cells: evidence of a new paracrine/autocrine regulation of luteal function. Prostaglandins F 46-49 endothelin 1 Homo sapiens 0-11 11306100-11 2001 Both CHCR1 and CHCR2 have prostaglandin 9-keto reductase and 15-hydroxyprostaglandin dehydrogenase activities towards PGE(2) and PGF(2alpha) from the analyses of enzymatic reaction products. Prostaglandins F 129-132 carbonyl reductase 1 Cricetulus griseus 5-10 11306100-11 2001 Both CHCR1 and CHCR2 have prostaglandin 9-keto reductase and 15-hydroxyprostaglandin dehydrogenase activities towards PGE(2) and PGF(2alpha) from the analyses of enzymatic reaction products. Prostaglandins F 129-132 carbonyl reductase 2 Cricetulus griseus 15-20 11162607-6 2001 CYP4F12 oxidized the omega-side chain of leukotriene B(4), PGE(2), PGF(2 alpha), PGH(2), and 9,11-epoxymethano-PGH(2) poorly. Prostaglandins F 67-70 cytochrome P450 family 4 subfamily F member 12 Homo sapiens 0-7 11133502-3 2001 PGE(2) (10(-7) to 10(-10) M) induced a dose-related increase in IL-6 release at 24 h. PGF(2 alpha) (10(-6) M) treatment caused a similar effect to that of PGE(2) (10(-7) M). Prostaglandins F 86-89 interleukin 6 Homo sapiens 64-68 11232027-6 2001 Western blot analysis, using a monoclonal antibody that detected the phosphorylated forms of extracellular signal-regulated kinases 1 and 2 (p42(mapk) and p44(mapk), respectively), demonstrated that PGF(2alpha) activated MAPK in hGLCs in a dose- and time-dependent manner. Prostaglandins F 199-202 mitogen-activated protein kinase 3 Homo sapiens 93-139 11232027-6 2001 Western blot analysis, using a monoclonal antibody that detected the phosphorylated forms of extracellular signal-regulated kinases 1 and 2 (p42(mapk) and p44(mapk), respectively), demonstrated that PGF(2alpha) activated MAPK in hGLCs in a dose- and time-dependent manner. Prostaglandins F 199-202 cyclin dependent kinase like 1 Homo sapiens 141-144 11232027-6 2001 Western blot analysis, using a monoclonal antibody that detected the phosphorylated forms of extracellular signal-regulated kinases 1 and 2 (p42(mapk) and p44(mapk), respectively), demonstrated that PGF(2alpha) activated MAPK in hGLCs in a dose- and time-dependent manner. Prostaglandins F 199-202 interferon induced protein 44 Homo sapiens 155-158 11232027-11 2001 Treatment of hGLCs with PGF(2alpha) significantly inhibited hCG-induced progesterone production. Prostaglandins F 24-27 hypertrichosis 2 (generalised, congenital) Homo sapiens 60-63 11139776-4 2001 In the in vitro microdialysis study, an infusion of LH alone or in combination with progesterone (P(4)), estradiol-17beta (E(2)) and/or ET-1 stimulated pronounced release of PGE(2), PGF(2alpha) and ET-1 in the oviducts from cows in the follicular and postovulatory phases. Prostaglandins F 182-185 endothelin 1 Bos taurus 136-140 11120820-6 2000 Interestingly, addition of PGF(2alpha), which was not known to affect lymphocytes, dramatically attenuated the deleterious effects of PPAR-gamma agonists on B lymphomas. Prostaglandins F 27-30 peroxisome proliferator activated receptor gamma Mus musculus 134-144 11232027-12 2001 The presence of the MEK inhibitor, PD98059, reversed the inhibitory effect of PGF(2alpha) on hCG-induced progesterone production. Prostaglandins F 78-81 mitogen-activated protein kinase kinase 7 Homo sapiens 20-23 11232027-12 2001 The presence of the MEK inhibitor, PD98059, reversed the inhibitory effect of PGF(2alpha) on hCG-induced progesterone production. Prostaglandins F 78-81 hypertrichosis 2 (generalised, congenital) Homo sapiens 93-96 11134359-4 2001 This was supported by the fact that in-vivo PGF(2 alpha) treatment enhanced nitric oxide synthase (NOS) activity. Prostaglandins F 44-47 nitric oxide synthase 2 Homo sapiens 76-97 11230325-8 2001 The ET-1-induced enhancement of PGF(2alpha) contraction was inhibited by Go6976 (10(-6) mol/L), an inhibitor of Ca(2+)-dependent PKC isoforms. Prostaglandins F 32-35 endothelin 1 Homo sapiens 4-8 11090440-0 2000 Expression of tenascin-C in stromal cells of the murine uterus during early pregnancy: induction by interleukin-1 alpha, prostaglandin E(2), and prostaglandin F(2 alpha). Prostaglandins F 145-160 tenascin C Mus musculus 14-24 11090440-6 2000 Addition of interleukin-1 alpha (IL-1 alpha) and prostaglandin E(2) (PGE(2)) and F(2 alpha) (PGF(2 alpha)) induced TN-C expression in the stromal cells at both protein and mRNA levels, while the sex steroid hormones, progesterone and ss-estradiol, exerted little effect. Prostaglandins F 93-96 interleukin 1 alpha Mus musculus 12-31 11090440-6 2000 Addition of interleukin-1 alpha (IL-1 alpha) and prostaglandin E(2) (PGE(2)) and F(2 alpha) (PGF(2 alpha)) induced TN-C expression in the stromal cells at both protein and mRNA levels, while the sex steroid hormones, progesterone and ss-estradiol, exerted little effect. Prostaglandins F 93-96 tenascin C Mus musculus 115-119 11090440-9 2000 Collectively, these findings indicate that TN-C expression in the preimplantation period is under the control of progesterone, but not directly, possibly by the paracrine and autocrine intervention of IL-1 alpha secreted by epithelial cells and PGE(2) and PGF(2 alpha) secreted by stromal cells. Prostaglandins F 256-259 tenascin C Mus musculus 43-47 11090464-3 2000 Increase in TNFRI mRNA levels was recorded both in regressed luteal tissue and in CL of cows injected with prostaglandin F(2 alpha). Prostaglandins F 107-122 TNF receptor superfamily member 1A Bos taurus 12-17 11093791-0 2000 Synthetic modification of prostaglandin f(2alpha) indicates different structural determinants for binding to the prostaglandin F receptor versus the prostaglandin transporter. Prostaglandins F 26-41 prostaglandin F receptor Homo sapiens 113-137 11093791-13 2000 Because extracellular PGF(2alpha) may compete for binding between FP receptors and PGT, these findings have implications for designing PGF(2alpha) analogs for treating disease states. Prostaglandins F 22-25 solute carrier organic anion transporter family member 2A1 Homo sapiens 83-86 11093791-13 2000 Because extracellular PGF(2alpha) may compete for binding between FP receptors and PGT, these findings have implications for designing PGF(2alpha) analogs for treating disease states. Prostaglandins F 135-138 solute carrier organic anion transporter family member 2A1 Homo sapiens 83-86 10973968-1 2000 Prostaglandin F(2)alpha (PGF(2)alpha) binding to its receptor on the rat corpus luteum triggers various signal transduction pathways that lead to the activation of a steroidogenic enzyme, 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), which in turn catabolizes progesterone. Prostaglandins F 25-28 aldo-keto reductase family 1, member C3 Rattus norvegicus 188-224 11097831-1 2000 Prostaglandin F(2alpha) (PGF(2alpha)), modulates hepatocyte functions via a heptahelical G(q)-coupled PGF(2alpha)-receptor (FP-R) which in liver is expressed exclusively in hepatocytes. Prostaglandins F 0-15 prostaglandin F receptor Rattus norvegicus 102-122 11097831-1 2000 Prostaglandin F(2alpha) (PGF(2alpha)), modulates hepatocyte functions via a heptahelical G(q)-coupled PGF(2alpha)-receptor (FP-R) which in liver is expressed exclusively in hepatocytes. Prostaglandins F 0-15 formyl peptide receptor 1 Mus musculus 124-128 11097831-1 2000 Prostaglandin F(2alpha) (PGF(2alpha)), modulates hepatocyte functions via a heptahelical G(q)-coupled PGF(2alpha)-receptor (FP-R) which in liver is expressed exclusively in hepatocytes. Prostaglandins F 25-28 prostaglandin F receptor Rattus norvegicus 102-122 11097831-1 2000 Prostaglandin F(2alpha) (PGF(2alpha)), modulates hepatocyte functions via a heptahelical G(q)-coupled PGF(2alpha)-receptor (FP-R) which in liver is expressed exclusively in hepatocytes. Prostaglandins F 25-28 formyl peptide receptor 1 Mus musculus 124-128 11090944-7 2000 In the mouse skin model of multistage carcinogenesis COX-2-derived prostaglandin F(2alpha) has been indentified as an endogenous tumor promoter. Prostaglandins F 67-82 prostaglandin-endoperoxide synthase 2 Homo sapiens 53-58 10973968-1 2000 Prostaglandin F(2)alpha (PGF(2)alpha) binding to its receptor on the rat corpus luteum triggers various signal transduction pathways that lead to the activation of a steroidogenic enzyme, 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), which in turn catabolizes progesterone. Prostaglandins F 25-28 aldo-keto reductase family 1, member C3 Rattus norvegicus 226-237 10973968-2 2000 The molecular mechanism underlying PGF(2)alpha-induced 20alpha-HSD enzyme activity has not yet been explored. Prostaglandins F 35-38 aldo-keto reductase family 1, member C18 Mus musculus 55-66 10973968-3 2000 In this report we show, using mice lacking PGF(2)alpha receptor and pregnant rats, that PGF(2)alpha is responsible for the rapid and massive expression of the 20alpha-HSD gene at the end of pregnancy leading to a decrease in progesterone secretion. Prostaglandins F 43-46 aldo-keto reductase family 1, member C3 Rattus norvegicus 159-170 10973968-4 2000 We also present evidence that PGF(2)alpha enhances 20alpha-HSD promoter activity. Prostaglandins F 30-33 aldo-keto reductase family 1, member C18 Mus musculus 51-62 10973968-5 2000 We have determined a region upstream of the -1590 position in the 20alpha-HSD promoter that confers regulation by PGF(2)alpha in ovarian primary cells. Prostaglandins F 114-117 aldo-keto reductase family 1, member C18 Mus musculus 66-77 10973968-7 2000 Deletion of this motif or overexpression of a NUR77 dominant negative protein caused a complete loss of 20alpha-HSD promoter activation by PGF(2)alpha. Prostaglandins F 139-142 nuclear receptor subfamily 4, group A, member 1 Mus musculus 46-51 10973968-7 2000 Deletion of this motif or overexpression of a NUR77 dominant negative protein caused a complete loss of 20alpha-HSD promoter activation by PGF(2)alpha. Prostaglandins F 139-142 aldo-keto reductase family 1, member C18 Mus musculus 104-115 10973968-10 2000 We also show that PGF(2)alpha induces a very rapid expression of NUR77 that binds to a distal response element located at -1599/-1606 but does not interact with another proximal putative NUR77 response element located downstream in the promoter. Prostaglandins F 18-21 nuclear receptor subfamily 4, group A, member 1 Mus musculus 65-70 10973968-10 2000 We also show that PGF(2)alpha induces a very rapid expression of NUR77 that binds to a distal response element located at -1599/-1606 but does not interact with another proximal putative NUR77 response element located downstream in the promoter. Prostaglandins F 18-21 nuclear receptor subfamily 4, group A, member 1 Mus musculus 187-192 10973968-13 2000 By using cyclosporin A and PGF(2)alpha treatment, we established that inhibition of NUR77 DNA binding in vivo prevents PGF(2)alpha induction of the 20alpha-HSD gene in the corpus luteum. Prostaglandins F 27-30 nuclear receptor subfamily 4, group A, member 1 Mus musculus 84-89 10973968-13 2000 By using cyclosporin A and PGF(2)alpha treatment, we established that inhibition of NUR77 DNA binding in vivo prevents PGF(2)alpha induction of the 20alpha-HSD gene in the corpus luteum. Prostaglandins F 119-122 nuclear receptor subfamily 4, group A, member 1 Mus musculus 84-89 10973968-13 2000 By using cyclosporin A and PGF(2)alpha treatment, we established that inhibition of NUR77 DNA binding in vivo prevents PGF(2)alpha induction of the 20alpha-HSD gene in the corpus luteum. Prostaglandins F 119-122 aldo-keto reductase family 1, member C18 Mus musculus 148-159 11030724-8 2000 Suppression of the contractions at the higher PGF(2)alpha concentrations was also seen in the fundus from EP(3)(-/-), EP(1)(-/-) and TP(-/-) mice and in the ileum from EP(3)(-/-) and TP(-/-) mice. Prostaglandins F 46-49 prostaglandin E receptor 3 (subtype EP3) Mus musculus 106-111 11049836-2 2000 In iNOS +/+ mice, contraction of carotid arteries in response to prostaglandin F(2alpha) (PGF(2alpha)) was impaired following TNF-alpha (100 microg/kg ip)(n = 10, P < 0.01). Prostaglandins F 65-80 nitric oxide synthase 2, inducible Mus musculus 3-7 11049836-2 2000 In iNOS +/+ mice, contraction of carotid arteries in response to prostaglandin F(2alpha) (PGF(2alpha)) was impaired following TNF-alpha (100 microg/kg ip)(n = 10, P < 0.01). Prostaglandins F 90-93 nitric oxide synthase 2, inducible Mus musculus 3-7 11049836-3 2000 In contrast to responses in wild-type mice, contraction to low concentrations of PGF(2alpha) were normal, but maximum contraction to PGF(2alpha) was impaired in arteries from iNOS -/- mice treated with TNF-alpha [0.35 +/-.0.02 g (n = 8) following vehicle and 0.25 +/- 0.02 g (n = 7) following TNF-alpha (P < 0.05)]. Prostaglandins F 133-136 nitric oxide synthase 2, inducible Mus musculus 175-179 11049836-3 2000 In contrast to responses in wild-type mice, contraction to low concentrations of PGF(2alpha) were normal, but maximum contraction to PGF(2alpha) was impaired in arteries from iNOS -/- mice treated with TNF-alpha [0.35 +/-.0.02 g (n = 8) following vehicle and 0.25 +/- 0.02 g (n = 7) following TNF-alpha (P < 0.05)]. Prostaglandins F 133-136 tumor necrosis factor Mus musculus 202-211 11049836-4 2000 Aminoguanidine, a relatively selective inhibitor of iNOS, partially restored contraction to PGF(2alpha) in vessels from iNOS +/+ mice but had no effect in iNOS -/- mice injected with TNF-alpha, suggesting that a mechanism(s) other than iNOS contributes to impaired responses. Prostaglandins F 92-95 nitric oxide synthase 2, inducible Mus musculus 52-56 11058524-3 2000 Enzymatic activity of PGDH, measured by rate of conversion of PGF(2alpha) to PGFM, was greater in corpora lutea on Day 4 of the estrous cycle (P < 0.05) and Day 13 of pregnancy (P < 0.05) than on Day 13 of the estrous cycle. Prostaglandins F 62-65 15-hydroxyprostaglandin dehydrogenase Homo sapiens 22-26 11058524-9 2000 In conclusion, enzymatic activity of PGDH may play an important role in the mechanism involved in luteal resistance to the luteolytic effects of PGF(2alpha). Prostaglandins F 145-148 15-hydroxyprostaglandin dehydrogenase Homo sapiens 37-41 11050286-3 2000 We found that treatment of the muscle with 2"-Amino-3"-methoxyflavone (PD98059) (10 microM), a specific inhibitor of MAP kinase kinase (MEK), inhibited significantly prostaglandin F(2alpha)- and latanoprost-induced phosphorylation and contraction, but had little effect on those evoked by carbachol. Prostaglandins F 166-181 mitogen-activated protein kinase kinase 7 Homo sapiens 136-139 11050286-6 2000 In contrast, the MAP kinase inhibitor inhibited prostaglandin F(2alpha)-induced myosin-light chain (MLC) phosphorylation, but had no effect on that of carbachol. Prostaglandins F 48-63 modulator of VRAC current 1 Homo sapiens 100-103 11050286-8 2000 It can be concluded that in this smooth muscle p42/p44 MAP kinases are involved in the mechanism of prostaglandin F(2alpha)-, but not in that of carbachol, induced contraction. Prostaglandins F 100-115 cyclin dependent kinase 20 Homo sapiens 47-50 11050286-8 2000 It can be concluded that in this smooth muscle p42/p44 MAP kinases are involved in the mechanism of prostaglandin F(2alpha)-, but not in that of carbachol, induced contraction. Prostaglandins F 100-115 interferon induced protein 44 Homo sapiens 51-54 10924071-13 2000 These findings indicate that: 1) PMA, acting through PKC and p38 kinase, enhances COX-2 expression, but chronic treatment with PMA partially inhibits IL-1beta stimulation of COX-2; and 2) exogenous PGF(2alpha) is involved in neonatal ventricular myocyte growth but endogenous COX-2 products are not. Prostaglandins F 198-201 interleukin 1 beta Homo sapiens 150-158 11023800-12 2000 hCG secretion by invading trophoblast appears to be negatively modulated by endothelin-1 (ET-1) and prostaglandin F(2alpha)(PGF2alpha), while tissue growth factors and collagenases are positive modulators of hCG expression.ProalphaC, an inhibin pro-monomer, may have some value in monitoring corpus luteum function. Prostaglandins F 100-115 hypertrichosis 2 (generalised, congenital) Homo sapiens 0-3 10893233-6 2000 274, 35944-35949) that stimulation of both isoforms with PGF(2 alpha) leads to activation of a Rho signaling pathway, resulting in tyrosine phosphorylation of p125 focal adhesion kinase, formation of actin stress fibers, and cell rounding. Prostaglandins F 57-60 SEC23 interacting protein Homo sapiens 159-163 10985975-3 2000 Vasodilatory responses to human synthetic CRH were measured during sub-maximal vasoconstriction of the fetal placental circulation with prostaglandin F(2alpha)(PGF(2alpha)) (1-100 micrometer). Prostaglandins F 136-151 corticotropin releasing hormone Homo sapiens 42-45 10985975-3 2000 Vasodilatory responses to human synthetic CRH were measured during sub-maximal vasoconstriction of the fetal placental circulation with prostaglandin F(2alpha)(PGF(2alpha)) (1-100 micrometer). Prostaglandins F 160-163 corticotropin releasing hormone Homo sapiens 42-45 10913376-5 2000 In intact rat aortae, cholesterol stimulates prostaglandin E(2) and prostaglandin F(2 alpha) production, an effect that can be completely prevented by inhibiting p38 MAPK, or COX-2. Prostaglandins F 68-83 mitogen activated protein kinase 14 Rattus norvegicus 162-165 10913376-5 2000 In intact rat aortae, cholesterol stimulates prostaglandin E(2) and prostaglandin F(2 alpha) production, an effect that can be completely prevented by inhibiting p38 MAPK, or COX-2. Prostaglandins F 68-83 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 175-180 10906040-4 2000 Our previous studies showed that endothelin-1 (ET-1), which is produced by the endothelial cells lining these blood vessels, plays a crucial role during PGF(2 alpha)-induced luteolysis. Prostaglandins F 153-156 endothelin 1 Bos taurus 33-45 10906040-4 2000 Our previous studies showed that endothelin-1 (ET-1), which is produced by the endothelial cells lining these blood vessels, plays a crucial role during PGF(2 alpha)-induced luteolysis. Prostaglandins F 153-156 endothelin 1 Bos taurus 47-51 10906040-5 2000 Therefore, in this study, we compared the effects of PGF(2 alpha) administered at the early and mid luteal phases on ET-1 and its type A receptors (ETA-R) along with plasma ET-1 and progesterone concentrations, and the mRNA levels of PGF(2 alpha) receptors (PGF(2 alpha)-R) and steroidogenic genes. Prostaglandins F 53-56 endothelin receptor type A Bos taurus 148-153 10906040-5 2000 Therefore, in this study, we compared the effects of PGF(2 alpha) administered at the early and mid luteal phases on ET-1 and its type A receptors (ETA-R) along with plasma ET-1 and progesterone concentrations, and the mRNA levels of PGF(2 alpha) receptors (PGF(2 alpha)-R) and steroidogenic genes. Prostaglandins F 53-56 endothelin 1 Bos taurus 117-121 10906040-6 2000 As expected, ET-1 and ETA-R mRNA levels were markedly induced in midcycle CL exposed to luteolytic dose of PGF(2 alpha) analogue (Cloprostenol). Prostaglandins F 107-110 endothelin 1 Bos taurus 13-17 10906040-6 2000 As expected, ET-1 and ETA-R mRNA levels were markedly induced in midcycle CL exposed to luteolytic dose of PGF(2 alpha) analogue (Cloprostenol). Prostaglandins F 107-110 endothelin receptor type A Bos taurus 22-27 10906040-8 2000 In accordance with ET-1 expression within the CL, plasma ET-1 concentrations were significantly elevated 24 h after PGF(2 alpha) injection only on Day 10 of the cycle. Prostaglandins F 116-119 endothelin 1 Bos taurus 19-23 10906040-8 2000 In accordance with ET-1 expression within the CL, plasma ET-1 concentrations were significantly elevated 24 h after PGF(2 alpha) injection only on Day 10 of the cycle. Prostaglandins F 116-119 endothelin 1 Bos taurus 57-61 10906040-9 2000 The steroidogenic capacity of the CL (plasma progesterone as well as the mRNA levels of steroidogenic acute regulatory protein and cytochrome P450(scc)) was only affected when PGF(2 alpha) was administered during midcycle. Prostaglandins F 176-179 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 131-152 10906045-1 2000 Antiluteolytic actions of bovine interferon-tau (bIFN-tau) require suppression of prostaglandin F(2 alpha) (PGF(2 alpha)) production. Prostaglandins F 82-97 interferon tau-2 Bos taurus 33-47 10906045-1 2000 Antiluteolytic actions of bovine interferon-tau (bIFN-tau) require suppression of prostaglandin F(2 alpha) (PGF(2 alpha)) production. Prostaglandins F 108-111 interferon tau-2 Bos taurus 33-47 10906045-7 2000 Added after a 3-h stimulation with PDBu alone, bIFN-tau suppressed PGF(2 alpha) production after 1 h. Bovine IFN-tau inhibited intracellular mechanisms responsible for PGF(2 alpha) production in BEND cells, and this could be through both cytosolic and nuclear actions. Prostaglandins F 67-70 interferon-tau-like Bos taurus 48-55 10906045-7 2000 Added after a 3-h stimulation with PDBu alone, bIFN-tau suppressed PGF(2 alpha) production after 1 h. Bovine IFN-tau inhibited intracellular mechanisms responsible for PGF(2 alpha) production in BEND cells, and this could be through both cytosolic and nuclear actions. Prostaglandins F 168-171 interferon-tau-like Bos taurus 48-55 10733897-0 2000 Prostaglandin F(2alpha) (PGF(2alpha)) induces cyclin D1 expression and DNA synthesis via early signaling mechanisms in Swiss mouse 3T3 cells. Prostaglandins F 0-15 cyclin D1 Mus musculus 46-55 10871652-6 2000 In conclusion, the decrease in Cu,Zn-SOD expression and the increase in lipid peroxide in the decidua could be involved in the termination of spontaneous abortion, mediated through the increase in PGF(2alpha) synthesis. Prostaglandins F 197-200 superoxide dismutase 1 Homo sapiens 37-40 10871652-7 2000 In other words, Cu,Zn-SOD may contribute to the maintenance of pregnancy by preventing the accumulation of superoxide radicals that cause PGF(2alpha) synthesis. Prostaglandins F 138-141 superoxide dismutase 1 Homo sapiens 22-25 10838124-6 2000 administration of angiotensin II, a uteroplacental vasodilator, before microwave exposure prevented the reduction in uteroplacental blood flow and the increased progesterone and PGF(2)alpha in pregnant rats. Prostaglandins F 178-181 angiotensinogen Rattus norvegicus 18-32 10733897-2 2000 In contrast, in PKC-depleted or -inhibited cells, PGF(2alpha), but not OAG, increases cyclin D1 expression with no mitogenic response. Prostaglandins F 50-53 cyclin D1 Mus musculus 86-95 10733897-4 2000 Thus, it appears that PGF(2alpha) triggers cyclin D1 expression via two independent signaling events that complement with TGF(beta1)-triggered events to induce DNA synthesis. Prostaglandins F 22-25 cyclin D1 Mus musculus 43-52 10727256-4 2000 The steady-state mRNA for MIF was examined in CL by Northern analysis on Day 5, Days 9-12, and Day 18 of the estrous cycle and at 0.5, 1, 4, 12, 24, and 36 h after a luteolytic injection of prostaglandin F(2alpha) (PGF(2alpha)) (n = 4 CL per time point). Prostaglandins F 190-205 macrophage migration inhibitory factor Bos taurus 26-29 10727256-4 2000 The steady-state mRNA for MIF was examined in CL by Northern analysis on Day 5, Days 9-12, and Day 18 of the estrous cycle and at 0.5, 1, 4, 12, 24, and 36 h after a luteolytic injection of prostaglandin F(2alpha) (PGF(2alpha)) (n = 4 CL per time point). Prostaglandins F 215-218 macrophage migration inhibitory factor Bos taurus 26-29 10727256-6 2000 Messenger RNA for MIF in CL collected 0.5 h post-PGF(2alpha) was greater than in midcycle and all other regressing CL. Prostaglandins F 49-52 macrophage migration inhibitory factor Bos taurus 18-21 10859236-9 2000 Data are presented demonstrating that stimulation of bovine luteal cells with PGF(2alpha) on Day 8 of the cycle promotes rapid phosphorylation of MARCKS protein and causes its translocation from the PM to the cytoplasm and concomitant, enhanced exocytosis of OT. Prostaglandins F 78-81 myristoylated alanine rich protein kinase C substrate Bos taurus 146-152 10859237-3 2000 Expression of insulin-like growth factor-binding protein-1 (IGFBP-1) was up-regulated, with greatest expression at 24 h (P < 0.05) after treatment with PGF(2alpha) began. Prostaglandins F 155-158 insulin like growth factor binding protein 1 Bos taurus 14-58 10859237-3 2000 Expression of insulin-like growth factor-binding protein-1 (IGFBP-1) was up-regulated, with greatest expression at 24 h (P < 0.05) after treatment with PGF(2alpha) began. Prostaglandins F 155-158 insulin like growth factor binding protein 1 Bos taurus 60-67 10859237-7 2000 IGFBP-1 mRNA was increased (P < 0.05) in CL 24 h after treatment when PGF(2alpha) that began on Day 10, and by 48 h after treatment that began on Day 4. Prostaglandins F 73-76 insulin like growth factor binding protein 1 Bos taurus 0-7 10859237-12 2000 Expression of IGFBP-1 was increased by 2 h after treatment with PGF(2alpha) on both Days 4 and 10 after estrus. Prostaglandins F 64-67 insulin like growth factor binding protein 1 Bos taurus 14-21 10989278-0 2000 p38 MAP kinase is involved in the signalling of sphingosine in osteoblasts: sphingosine inhibits prostaglandin F(2alpha)-induced phosphoinositide hydrolysis. Prostaglandins F 97-112 mitogen-activated protein kinase 14 Mus musculus 0-3 10989278-1 2000 We previously showed that sphingosine inhibits prostaglandin F(2alpha) (PGF(2alpha))-stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells. Prostaglandins F 47-62 interleukin 6 Mus musculus 96-109 10989278-1 2000 We previously showed that sphingosine inhibits prostaglandin F(2alpha) (PGF(2alpha))-stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells. Prostaglandins F 72-75 interleukin 6 Mus musculus 96-109 10989278-5 2000 SB203580 and PD169316, inhibitors of p38 MAP kinase, rescued the inhibitory effect of sphingosine on the formation of inositol phosphates by PGF(2alpha) or NaF. Prostaglandins F 141-144 mitogen-activated protein kinase 14 Mus musculus 37-40 10989278-6 2000 These results indicate that sphingosine inhibits PGF(2alpha)-induced phosphoinositide hydrolysis by phospholipase C via p38 MAP kinase in osteoblasts. Prostaglandins F 49-52 mitogen-activated protein kinase 14 Mus musculus 120-123 10913228-7 2000 The phosphorylation of p42/p44 MAP kinase by PGF alpha was attenuated by PD98059. Prostaglandins F 45-48 cyclin-dependent kinase 20 Mus musculus 23-26 10913228-7 2000 The phosphorylation of p42/p44 MAP kinase by PGF alpha was attenuated by PD98059. Prostaglandins F 45-48 mitogen-activated protein kinase 3 Mus musculus 27-30 10775155-0 2000 Is tumor necrosis factor alpha a trigger for the initiation of endometrial prostaglandin F(2alpha) release at luteolysis in cattle? Prostaglandins F 75-90 tumor necrosis factor Bos taurus 3-30 10775155-1 2000 To determine the physiological significance of tumor necrosis factor alpha (TNFalpha) in the regulation of luteolytic prostaglandin (PG) F(2alpha) release by the bovine endometrium, the effect of TNF-alpha on PGF(2alpha) output by the endometrial tissues in vitro was investigated and compared with the effect of oxytocin (OT). Prostaglandins F 118-138 tumor necrosis factor Bos taurus 47-74 10775155-1 2000 To determine the physiological significance of tumor necrosis factor alpha (TNFalpha) in the regulation of luteolytic prostaglandin (PG) F(2alpha) release by the bovine endometrium, the effect of TNF-alpha on PGF(2alpha) output by the endometrial tissues in vitro was investigated and compared with the effect of oxytocin (OT). Prostaglandins F 118-138 tumor necrosis factor Bos taurus 76-84 10775155-5 2000 On the other hand, the stimulatory effects of TNFalpha on PGF(2alpha) output were observed not only at the follicular stage but also at the late luteal stage (P < 0.001). Prostaglandins F 58-61 tumor necrosis factor Bos taurus 46-54 10775155-6 2000 When the endometrial tissues at late luteal stage were simultaneously exposed to TNFalpha (0.6 nM) and OT (100 nM), the stimulatory effect on PGF(2alpha) output was higher than the effect of TNFalpha or OT alone (P < 0.05). Prostaglandins F 142-145 tumor necrosis factor Bos taurus 81-89 10775155-10 2000 The overall results lead us to hypothesize that TNFalpha may be a trigger for the output of PGF(2alpha) by the endometrium at the initiation of luteolysis in cattle. Prostaglandins F 92-95 tumor necrosis factor Bos taurus 48-56 10775156-0 2000 Production of prostaglandin f(2alpha) by cultured bovine endometrial cells in response to tumor necrosis factor alpha: cell type specificity and intracellular mechanisms. Prostaglandins F 14-29 tumor necrosis factor Bos taurus 90-117 10775156-1 2000 Tumor necrosis factor alpha (TNFalpha) has been shown to be a potent stimulator of prostaglandin (PG) F(2alpha) secretion in the bovine endometrium. Prostaglandins F 83-103 tumor necrosis factor Bos taurus 0-27 10775156-1 2000 Tumor necrosis factor alpha (TNFalpha) has been shown to be a potent stimulator of prostaglandin (PG) F(2alpha) secretion in the bovine endometrium. Prostaglandins F 83-103 tumor necrosis factor Bos taurus 29-37 10775156-2 2000 The aims of the present study were to determine the cell types in the endometrium (epithelial or stromal cells) responsible for the secretion of PGF(2alpha) in response to TNFalpha, and the intracellular mechanisms of TNFalpha action. Prostaglandins F 145-148 tumor necrosis factor Bos taurus 172-180 10775156-3 2000 Cultured bovine epithelial and stromal cells were exposed to TNFalpha (0.006-6 nM) or oxytocin (100 nM) for 4 h. TNFalpha resulted in a dose-dependent increase of PGF(2alpha) production in the stromal cells (P < 0.001) but not in the epithelial cells. Prostaglandins F 163-166 tumor necrosis factor Bos taurus 61-69 10775156-3 2000 Cultured bovine epithelial and stromal cells were exposed to TNFalpha (0.006-6 nM) or oxytocin (100 nM) for 4 h. TNFalpha resulted in a dose-dependent increase of PGF(2alpha) production in the stromal cells (P < 0.001) but not in the epithelial cells. Prostaglandins F 163-166 tumor necrosis factor Bos taurus 113-121 10775156-8 2000 Although an NO synthase (NOS) inhibitor (L-NAME) reduced TNFalpha-stimulated PGF(2alpha) production, an inhibitor of phosphodiesterase augmented the actions of TNFalpha and S-NAP (P < 0. Prostaglandins F 77-80 tumor necrosis factor Bos taurus 57-65 10775156-10 2000 The overall results indicate that the target of TNFalpha for stimulation of PGF(2alpha) production in cattle is the endometrial stromal cells, and that the actions of TNFalpha are mediated via the activation of PLA(2) and arachidonic acid conversion. Prostaglandins F 76-79 tumor necrosis factor Bos taurus 48-56 10775156-11 2000 Moreover, TNFalpha may exert a stimulatory effect on PGF(2alpha) production via the induction of NOS and the subsequent NO-cGMP formation. Prostaglandins F 53-56 tumor necrosis factor Bos taurus 10-18 18726371-8 2000 PGF(2alpha) inhibited expression of IGF-IR and LHR. Prostaglandins F 0-3 insulin-like growth factor 1 receptor Rattus norvegicus 36-42 18726371-8 2000 PGF(2alpha) inhibited expression of IGF-IR and LHR. Prostaglandins F 0-3 luteinizing hormone/choriogonadotropin receptor Rattus norvegicus 47-50 18726371-11 2000 Inhibited expression of IGF-IR by PGF(2alpha) may be part of mechanisms for regression of CL. Prostaglandins F 34-37 insulin-like growth factor 1 receptor Rattus norvegicus 24-30 10688636-11 2000 Because PGF(1alpha) is the stable breakdown product of PGI(2), these results suggest that COX-2 contributes to PGI(2) synthesis in the rat stomach. Prostaglandins F 8-11 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 90-95 10700516-5 2000 RESULTS: After submaximal precontraction with U46619 or prostaglandin F(2alpha), acetylcholine, which produces relaxation mediated by endothelial nitric oxide synthase, produced marked relaxation of carotid arteries in control mice but was impaired in R+/A+ mice. Prostaglandins F 56-71 nitric oxide synthase 3, endothelial cell Mus musculus 134-167 10642586-12 2000 Intact UGKO ewes displayed altered estrous cycles with interestrous intervals of 17 to 43 days, and they responded to exogenous prostaglandin F(2 approximately ) (PGF) with luteolysis and behavioral estrus. Prostaglandins F 128-143 placenta growth factor Ovis aries 163-166 10764976-11 2000 IFN-tau may regulate the PGF(2a) synthetic pathway by reducing activity of PKC or PKC mediated events. Prostaglandins F 25-28 interferon-tau-like Bos taurus 0-7 10764980-9 2000 When estrus was induced by PGF(2alpha), plasma IGF-I concentrations increased after treatment, and the concentration 2 days after treatment (day of appearance of behavioral estrus) was significantly higher than concentrations before treatment (P<0.05). Prostaglandins F 27-30 insulin-like growth factor I Capra hircus 47-52 10657853-4 2000 Using specific inhibitors, we found that the regulatory actions of PGE-2 in vitro are mediated via the adenyl cyclase/protein kinase A (PKA) second messenger system, while the PGF-2alpha-induced luteolytic effects on day-9 CL depend upon activation of the phospholipase C/protein kinase C (PKC) system. Prostaglandins F 176-179 LOC100009319 Oryctolagus cuniculus 256-271 10648645-0 2000 Differential regulation of prostaglandin F(2alpha) receptor isoforms by protein kinase C. Prostaglandin F(2alpha) receptors (FP) are G protein-coupled receptors that bind prostaglandin F(2alpha) (PGF(2alpha)), resulting in the activation of an inositol phosphate (IP) second messenger pathway. Prostaglandins F 196-199 prostaglandin F receptor Homo sapiens 27-59 10648645-5 2000 We now report that pretreatment with the PKC inhibitor bisindolylmaleimide I enhanced PGF(2alpha)-stimulated IP accumulation in transfected cells stably expressing the FP(A) isoform but not in cells stably expressing the FP(B) isoform. Prostaglandins F 86-89 protein kinase C alpha Homo sapiens 41-44 10733897-0 2000 Prostaglandin F(2alpha) (PGF(2alpha)) induces cyclin D1 expression and DNA synthesis via early signaling mechanisms in Swiss mouse 3T3 cells. Prostaglandins F 25-28 cyclin D1 Mus musculus 46-55 10733897-1 2000 Prostaglandin F(2alpha) (PGF(2alpha)), a mitogen for Swiss 3T3 cells, triggers cyclin D1 mRNA/protein expression prior to cellular entry into the S phase, but fails to raise cdk4 or cyclin D3 levels, while 1-oleoyl-2-diacylglycerol (OAG), a protein kinase C (PKC) and tyrosine kinase (TK) activator, induces only cyclin D1 expression with no mitogenic response. Prostaglandins F 0-15 cyclin D1 Mus musculus 79-88 10733897-1 2000 Prostaglandin F(2alpha) (PGF(2alpha)), a mitogen for Swiss 3T3 cells, triggers cyclin D1 mRNA/protein expression prior to cellular entry into the S phase, but fails to raise cdk4 or cyclin D3 levels, while 1-oleoyl-2-diacylglycerol (OAG), a protein kinase C (PKC) and tyrosine kinase (TK) activator, induces only cyclin D1 expression with no mitogenic response. Prostaglandins F 25-28 cyclin D1 Mus musculus 79-88 10572244-0 1999 Involvement of p42/p44 mitogen-activated protein kinase in prostaglandin f(2alpha)-stimulated induction of heat shock protein 27 in osteoblasts. Prostaglandins F 59-74 cyclin-dependent kinase 20 Mus musculus 15-18 10611076-5 2000 At high concentrations, however, recombinant ovine (ro) IFN-tau acts on epithelial cells by changing the primary PG produced from PGF(2alpha) to PGE(2). Prostaglandins F 130-133 interferon-tau-like Bos taurus 56-63 10611085-8 2000 When cultured cells of all luteal stages were exposed to TNF-alpha (1-100 ng/ml), TNF-alpha stimulated prostaglandin F(2alpha) and prostaglandin E(2) secretion by the cells in a dose-dependent fashion (P < 0.01), especially during the early luteal phase, although it did not affect progesterone secretion. Prostaglandins F 103-118 tumor necrosis factor Bos taurus 57-66 10611085-8 2000 When cultured cells of all luteal stages were exposed to TNF-alpha (1-100 ng/ml), TNF-alpha stimulated prostaglandin F(2alpha) and prostaglandin E(2) secretion by the cells in a dose-dependent fashion (P < 0.01), especially during the early luteal phase, although it did not affect progesterone secretion. Prostaglandins F 103-118 tumor necrosis factor Bos taurus 82-91 10625880-6 2000 In the GnRH-PGF-hCG protocol, hCG administration induced earlier ovulation (67.4 h, P<0.01) compared to the control group (GnRH-PGF) and a better synchronization of ovulation, since most of it occurred within a period of 12 to 17 h. Pregnancy rate after timed AI was 42.8 (3/7, GPh-d6) to 50% (7/14, GPh-d7). Prostaglandins F 12-15 glycoprotein hormones, alpha polypeptide Homo sapiens 16-19 10625880-6 2000 In the GnRH-PGF-hCG protocol, hCG administration induced earlier ovulation (67.4 h, P<0.01) compared to the control group (GnRH-PGF) and a better synchronization of ovulation, since most of it occurred within a period of 12 to 17 h. Pregnancy rate after timed AI was 42.8 (3/7, GPh-d6) to 50% (7/14, GPh-d7). Prostaglandins F 12-15 glycoprotein hormones, alpha polypeptide Homo sapiens 30-33 11093043-7 2000 The infusion of PGF(2alpha) in pregnant rats caused and increased COX-2 expression in the myometrium while it caused a decreased expression in the endometrium. Prostaglandins F 16-19 cytochrome c oxidase II, mitochondrial Rattus norvegicus 66-71 10572244-0 1999 Involvement of p42/p44 mitogen-activated protein kinase in prostaglandin f(2alpha)-stimulated induction of heat shock protein 27 in osteoblasts. Prostaglandins F 59-74 mitogen-activated protein kinase 3 Mus musculus 19-22 10572244-0 1999 Involvement of p42/p44 mitogen-activated protein kinase in prostaglandin f(2alpha)-stimulated induction of heat shock protein 27 in osteoblasts. Prostaglandins F 59-74 heat shock protein 1 Mus musculus 107-128 10572244-2 1999 In this study, we investigated the effect of PGF(2alpha) on the induction of heat shock protein 27 (HSP27), a low-molecular-weight heat shock protein, in these cells. Prostaglandins F 45-48 heat shock protein 1 Mus musculus 77-98 10572244-2 1999 In this study, we investigated the effect of PGF(2alpha) on the induction of heat shock protein 27 (HSP27), a low-molecular-weight heat shock protein, in these cells. Prostaglandins F 45-48 heat shock protein 1 Mus musculus 100-105 10572244-3 1999 PGF(2alpha) significantly induced the accumulation of HSP27 dose-dependently within the range of 10 nM to 10 microM. Prostaglandins F 0-3 heat shock protein 1 Mus musculus 54-59 10572244-4 1999 PGF(2alpha) stimulated the increase in the levels of mRNA for HSP27. Prostaglandins F 0-3 heat shock protein 1 Mus musculus 62-67 10572244-7 1999 Calphostin C, a specific inhibitor of PKC, suppressed the PGF(2alpha)-induced HSP27 accumulation as well as that induced by TPA. Prostaglandins F 58-61 heat shock protein 1 Mus musculus 78-83 10572244-8 1999 HSP27 induction by PGF(2alpha) was reduced by U-73122, a phospholipase C inhibitor, or propranolol, a phosphatidic acid phosphohydrolase inhibitor. Prostaglandins F 19-22 heat shock protein 1 Mus musculus 0-5 10572244-9 1999 PGF(2alpha) and TPA stimulated p42/p44 mitogen-activated protein (MAP) kinase. Prostaglandins F 0-3 cyclin-dependent kinase 20 Mus musculus 31-34 10572244-9 1999 PGF(2alpha) and TPA stimulated p42/p44 mitogen-activated protein (MAP) kinase. Prostaglandins F 0-3 mitogen-activated protein kinase 3 Mus musculus 35-38 10572244-10 1999 PD98059, an inhibitor of the upstream kinase that activates p42/p44 MAP kinase, suppressed the induction of HSP27 stimulated by PGF(2alpha) or TPA. Prostaglandins F 128-131 cyclin-dependent kinase 20 Mus musculus 60-63 10572244-10 1999 PD98059, an inhibitor of the upstream kinase that activates p42/p44 MAP kinase, suppressed the induction of HSP27 stimulated by PGF(2alpha) or TPA. Prostaglandins F 128-131 mitogen-activated protein kinase 3 Mus musculus 64-78 10572244-10 1999 PD98059, an inhibitor of the upstream kinase that activates p42/p44 MAP kinase, suppressed the induction of HSP27 stimulated by PGF(2alpha) or TPA. Prostaglandins F 128-131 heat shock protein 1 Mus musculus 108-113 10572244-11 1999 PD98059 and calphostin C reduced the levels of mRNA for HSP27 increased by PGF(2alpha). Prostaglandins F 75-78 heat shock protein 1 Mus musculus 56-61 10572244-12 1999 These results indicate that PGF(2alpha) stimulates the induction of HSP27 via p42/p44 MAP kinase activation, which depends on upstream PKC activation in osteoblasts. Prostaglandins F 28-31 heat shock protein 1 Mus musculus 68-73 10572244-12 1999 These results indicate that PGF(2alpha) stimulates the induction of HSP27 via p42/p44 MAP kinase activation, which depends on upstream PKC activation in osteoblasts. Prostaglandins F 28-31 cyclin-dependent kinase 20 Mus musculus 78-81 10572244-12 1999 These results indicate that PGF(2alpha) stimulates the induction of HSP27 via p42/p44 MAP kinase activation, which depends on upstream PKC activation in osteoblasts. Prostaglandins F 28-31 mitogen-activated protein kinase 3 Mus musculus 82-85 10569999-0 1999 Insulin-like growth factor (IGF)-I, IGF-I receptor, and IGF binding protein-3 messenger ribonucleic acids and protein in corpora lutea from prostaglandin F(2alpha)-treated gilts. Prostaglandins F 140-155 insulin like growth factor 1 Homo sapiens 0-34 10569999-0 1999 Insulin-like growth factor (IGF)-I, IGF-I receptor, and IGF binding protein-3 messenger ribonucleic acids and protein in corpora lutea from prostaglandin F(2alpha)-treated gilts. Prostaglandins F 140-155 insulin like growth factor binding protein 3 Homo sapiens 56-77 10569999-2 1999 This study examines the hypotheses that the luteolytic actions of prostaglandin F(2alpha) (PGF(2alpha)) during the early luteal phase may involve either a decrease in IGF-I or IGF receptor (IGF-IR), or an increase in IGF binding protein (IGFBP)-3, expression, any of which could interfere with the luteotropic actions of IGF-I in this tissue. Prostaglandins F 66-81 insulin like growth factor 1 receptor Homo sapiens 167-188 10569999-2 1999 This study examines the hypotheses that the luteolytic actions of prostaglandin F(2alpha) (PGF(2alpha)) during the early luteal phase may involve either a decrease in IGF-I or IGF receptor (IGF-IR), or an increase in IGF binding protein (IGFBP)-3, expression, any of which could interfere with the luteotropic actions of IGF-I in this tissue. Prostaglandins F 66-81 insulin like growth factor 1 Homo sapiens 167-172 10569999-2 1999 This study examines the hypotheses that the luteolytic actions of prostaglandin F(2alpha) (PGF(2alpha)) during the early luteal phase may involve either a decrease in IGF-I or IGF receptor (IGF-IR), or an increase in IGF binding protein (IGFBP)-3, expression, any of which could interfere with the luteotropic actions of IGF-I in this tissue. Prostaglandins F 91-94 insulin like growth factor 1 Homo sapiens 167-172 10569999-8 1999 IGF-IR levels, determined from Western blots, were higher on Day 7 (P < 0.05) and lower on Day 9 in PGF(2alpha)-treated animals vs. control animals (P < 0.05). Prostaglandins F 103-106 insulin like growth factor 1 receptor Homo sapiens 0-6 10569999-9 1999 In conclusion, PGF(2alpha)-induced premature luteolysis was associated with an increase in steady-state levels of IGF-IR mRNA, but it did not appear to be linked to changes in mRNA levels for IGF-I or IGFBP-3. Prostaglandins F 15-18 insulin like growth factor 1 receptor Homo sapiens 114-120 10569999-9 1999 In conclusion, PGF(2alpha)-induced premature luteolysis was associated with an increase in steady-state levels of IGF-IR mRNA, but it did not appear to be linked to changes in mRNA levels for IGF-I or IGFBP-3. Prostaglandins F 15-18 insulin like growth factor 1 Homo sapiens 114-119 10569999-9 1999 In conclusion, PGF(2alpha)-induced premature luteolysis was associated with an increase in steady-state levels of IGF-IR mRNA, but it did not appear to be linked to changes in mRNA levels for IGF-I or IGFBP-3. Prostaglandins F 15-18 insulin like growth factor binding protein 3 Homo sapiens 201-208 10569999-10 1999 However, since IGFBP-2 and -3 protein levels increased early in the treatment period (Days 6-7), it is possible that they may mediate the luteolytic actions of PGF(2alpha) by sequestering IGF-I and preventing its interaction with the IGF-IR. Prostaglandins F 160-163 insulin like growth factor binding protein 2 Homo sapiens 15-29 10444373-7 1999 The in vitro ovarian production of PGE and PGF(2alpha) was inhibited by L-NAME and stimulated by 3-morpho-linosydnonimine (SIN-1), a NO donor. Prostaglandins F 43-46 MAPK associated protein 1 Homo sapiens 123-128 10724331-3 2000 IL-1 enhanced steady state levels of COX-2 protein and mRNA synthesis by approximately 2-fold which preceded a 2-fold increase in PGF(alpha) biosynthesis. Prostaglandins F 130-133 interleukin 1 beta Homo sapiens 0-4 10637124-7 1999 When pancreatic arachidonic acid (AA) conversion to prostaglandins was explored, ET-1 increased PGF(2alpha), PGE(2), and TXB(2) levels in C but not in D tissues. Prostaglandins F 96-99 endothelin 1 Rattus norvegicus 81-85 10556836-5 1999 In contrast, COX-2 and the prostanoids PGE(2), PGF(2alpha) and PGD(2) are highly inducible in B/ macrophage cells upon stimulation with lipopolysaccharide, CD40 ligand, or via engagement of surface IgM, supporting a role for these cells in inflammation. Prostaglandins F 47-50 cytochrome c oxidase II, mitochondrial Mus musculus 13-18 10556836-5 1999 In contrast, COX-2 and the prostanoids PGE(2), PGF(2alpha) and PGD(2) are highly inducible in B/ macrophage cells upon stimulation with lipopolysaccharide, CD40 ligand, or via engagement of surface IgM, supporting a role for these cells in inflammation. Prostaglandins F 47-50 CD40 antigen Mus musculus 156-160 10629420-8 1999 The C allele of the AGT1R gene was associated with an increase in sensitivity to prostaglandin F(2alpha) but not with alteration to the other vasoactive agents studied. Prostaglandins F 81-96 angiotensin II receptor type 1 Homo sapiens 20-25 10464289-1 1999 We have identified a cDNA, PGT, that encodes a widely expressed transporter for prostaglandin (PG) E(2), PGF(2alpha), PGD(2), 8-iso-PGF(2alpha), and thromboxane B(2). Prostaglandins F 105-108 solute carrier organic anion transporter family member 2A1 Homo sapiens 27-30 10484384-9 1999 We conclude that group I sPLA2 may mediate "spontaneous" LES tone by producing AA, which is metabolized to PGF(2alpha) and thromboxane A2. Prostaglandins F 107-110 phospholipase A2 group IIA Homo sapiens 25-30 10456840-0 1999 Prostaglandin F(2alpha) induces a rapid decline in progesterone production and steroidogenic acute regulatory protein expression in isolated rat corpus luteum without altering messenger ribonucleic acid expression. Prostaglandins F 0-15 steroidogenic acute regulatory protein Rattus norvegicus 79-117 10456840-7 1999 Serum progesterone levels and expression of the 30-kDa and 37-kDa forms of the StAR protein in CL were all found to be significantly lower in the PGF(2alpha)-treated than the saline-treated group. Prostaglandins F 146-149 steroidogenic acute regulatory protein Rattus norvegicus 79-83 10456840-9 1999 The rapid decline in StAR protein expression that accompanies PGF(2alpha) induced luteolysis, therefore, does not result from significant decline in mRNA expression. Prostaglandins F 62-65 steroidogenic acute regulatory protein Rattus norvegicus 21-25 10454462-7 1999 Only when concentrations exceeded those likely to activate 5-HT(1B) and 5-HT(1D) receptors (>10(-5) M) did modest contractile responses occur in the presence of PGF(2alpha). Prostaglandins F 164-167 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 59-66 10444477-7 1999 In vitro, increases in tension caused by N(omega)-nitro-L-arginine (L-NNA) or PGF(2alpha) in arterial rings were reduced by ET(A)- but not ET(B)-receptor blockade. Prostaglandins F 78-81 endothelin receptor type A Homo sapiens 124-130 10411528-2 1999 Intrauterine administration of recombinant ovine IFNtau suppresses expression of endometrial estrogen receptor (ER) and oxytocin receptor (OTR) in the luminal and superficial glandular epithelia to abrogate the production of luteolytic prostaglandin F(2alpha) (PGF(2alpha)) pulses. Prostaglandins F 236-251 oxytocin receptor Ovis aries 139-142 10411528-2 1999 Intrauterine administration of recombinant ovine IFNtau suppresses expression of endometrial estrogen receptor (ER) and oxytocin receptor (OTR) in the luminal and superficial glandular epithelia to abrogate the production of luteolytic prostaglandin F(2alpha) (PGF(2alpha)) pulses. Prostaglandins F 261-264 oxytocin receptor Ovis aries 139-142 10444373-9 1999 Our results suggest that the inducible NOs (iNOs) is the main isoform involved in the ovulatory process and that the NO produced stimulates the synthesis of both PGE and PGF(2alpha) from the cyclooxygenase pathway, to enhance the process of follicle rupture. Prostaglandins F 170-173 nitric oxide synthase 2 Rattus norvegicus 29-42 10444373-9 1999 Our results suggest that the inducible NOs (iNOs) is the main isoform involved in the ovulatory process and that the NO produced stimulates the synthesis of both PGE and PGF(2alpha) from the cyclooxygenase pathway, to enhance the process of follicle rupture. Prostaglandins F 170-173 nitric oxide synthase 2 Rattus norvegicus 44-48 10411547-5 1999 In contrast, AT(2)-null mice had lower PGF(2alpha) levels compared with WT mice during basal conditions and in response to dietary sodium restriction or infusion of Ang II. Prostaglandins F 39-42 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 165-171 9780335-0 1998 Oxytocin-stimulated phosphoinositide hydrolysis and prostaglandin F secretion by luminal epithelial, glandular epithelial, and stromal cells from pig endometrium. Prostaglandins F 52-67 oxytocin/neurophysin I prepropeptide Sus scrofa 0-8 10981059-7 1999 The AT(2) receptor also appears to mediate prostaglandin (PG) F(2)(a) formation, probably by stimulating conversion of PGE2 to PGF(2)(a). Prostaglandins F 43-63 placental growth factor Homo sapiens 127-130 16728198-6 1997 In the 36 h after injection of PGF 2alpha, serum progesterone (P4) had declined to basal levels in the control cycles when GnRH was administered, but P4 concentrations were higher in the early group and were highest in the late group when the GnRH was administered with PGF 2alpha. Prostaglandins F 31-34 gonadotropin releasing hormone 1 Homo sapiens 123-127 9795373-5 1998 IGF-I (10 ng/ml or more) inhibited androstenedione and PGF secretion, stimulated testosterone, estradiol, OT and cAMP production, but did not influence progesterone, IGFBP-3 or PGE output in these conditions. Prostaglandins F 55-58 insulin like growth factor 1 Homo sapiens 0-5 9795373-6 1998 OT (100 ng/ml) was able to inhibit androstenedione and to stimulate testosterone, IGF-I, PGF and PGE, but not estradiol or IGFBP-3 release. Prostaglandins F 89-92 oxytocin/neurophysin I prepropeptide Homo sapiens 0-2 9536967-7 1998 The nontreated, heat-treated, or trypsin-digested in vivo PGF was incubated with an in vitro [3H]thymidine murine fibroblast (ATCC CCL-12) proliferation assay. Prostaglandins F 58-61 chemokine (C-C motif) ligand 12 Mus musculus 131-137 9795373-1 1998 The aim of our in vitro experiments with isolated porcine ovarian follicles was to study the effects of gonadotropins, GH, IGF-I and oxytocin (OT) on release of ovarian steroid, OT, IGF-I, insulin-like growth factor-binding protein-3 (IGFBP-3), prostaglandin F (PGF), prostaglandin E (PGE) and cAMP. Prostaglandins F 245-260 oxytocin/neurophysin I prepropeptide Homo sapiens 143-145 9795373-1 1998 The aim of our in vitro experiments with isolated porcine ovarian follicles was to study the effects of gonadotropins, GH, IGF-I and oxytocin (OT) on release of ovarian steroid, OT, IGF-I, insulin-like growth factor-binding protein-3 (IGFBP-3), prostaglandin F (PGF), prostaglandin E (PGE) and cAMP. Prostaglandins F 262-265 oxytocin/neurophysin I prepropeptide Homo sapiens 143-145 9865498-7 1998 In order to maintain luteal progesterone secretion, IFN-tau inhibits PGF-2alpha pulsatile secretion and oxytocin uterine receptivity in early pregnancy. Prostaglandins F 69-72 interferon alpha 1 Homo sapiens 52-55 16728198-6 1997 In the 36 h after injection of PGF 2alpha, serum progesterone (P4) had declined to basal levels in the control cycles when GnRH was administered, but P4 concentrations were higher in the early group and were highest in the late group when the GnRH was administered with PGF 2alpha. Prostaglandins F 31-34 gonadotropin releasing hormone 1 Homo sapiens 243-247