PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17323380-8	2007	Finally, co-stimulation with PHA and progesterone or amiloride, (5-(N, N-dimethyl)-amiloride, DMA), inhibited PHA-induced T-cell proliferation, but this inhibition did not occur with 20alpha-OHP and PHA co-stimulation.	20alpha-ohp	183-194	major histocompatibility complex, class II, DM alpha	Homo sapiens	94-97
28729436-3	2017	Transfection of Y1 adrenal cells with miR-132 increased mRNAs of 3beta-HSD and 20alpha-HSD enzymes, which catalyze the sequential conversion of pregnenolone to progesterone to biologically inactive 20alpha-hydroxyprogesterone (20alpha-OHP).	20alpha-ohp	227-238	microRNA 132	Homo sapiens	38-45
28729436-3	2017	Transfection of Y1 adrenal cells with miR-132 increased mRNAs of 3beta-HSD and 20alpha-HSD enzymes, which catalyze the sequential conversion of pregnenolone to progesterone to biologically inactive 20alpha-hydroxyprogesterone (20alpha-OHP).	20alpha-ohp	227-238	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	65-74
28729436-3	2017	Transfection of Y1 adrenal cells with miR-132 increased mRNAs of 3beta-HSD and 20alpha-HSD enzymes, which catalyze the sequential conversion of pregnenolone to progesterone to biologically inactive 20alpha-hydroxyprogesterone (20alpha-OHP).	20alpha-ohp	227-238	hydroxysteroid 17-beta dehydrogenase 2	Homo sapiens	79-90
28729436-5	2017	Use of [3H] pregnenolone and free-diffusible 22(R)-hydroxycholesterol further confirmed that miR-132 promotes the production of 20alpha-OHP by upregulating 3beta-HSD and 20alpha-HSD.	20alpha-ohp	128-139	microRNA 132	Homo sapiens	93-100
28729436-5	2017	Use of [3H] pregnenolone and free-diffusible 22(R)-hydroxycholesterol further confirmed that miR-132 promotes the production of 20alpha-OHP by upregulating 3beta-HSD and 20alpha-HSD.	20alpha-ohp	128-139	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	156-165
28729436-5	2017	Use of [3H] pregnenolone and free-diffusible 22(R)-hydroxycholesterol further confirmed that miR-132 promotes the production of 20alpha-OHP by upregulating 3beta-HSD and 20alpha-HSD.	20alpha-ohp	128-139	hydroxysteroid 17-beta dehydrogenase 2	Homo sapiens	170-181
24330451-2	2013	In rodents, it is well recognized that during luteolysis, P4 is catabolized to its inactive metabolite, 20alpha-hydroxyprogesterone (20alpha-OHP) by the action of 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) enzyme and involves transcription factor, Nur77.	20alpha-ohp	133-144	aldo-keto reductase family 1 member B1	Bos taurus	163-199
24330451-2	2013	In rodents, it is well recognized that during luteolysis, P4 is catabolized to its inactive metabolite, 20alpha-hydroxyprogesterone (20alpha-OHP) by the action of 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) enzyme and involves transcription factor, Nur77.	20alpha-ohp	133-144	aldo-keto reductase family 1 member B1	Bos taurus	201-212
24330451-2	2013	In rodents, it is well recognized that during luteolysis, P4 is catabolized to its inactive metabolite, 20alpha-hydroxyprogesterone (20alpha-OHP) by the action of 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) enzyme and involves transcription factor, Nur77.	20alpha-ohp	133-144	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	256-261
15703459-1	2005	20Alpha-hydroxysteroid dehydrogenase (20alpha-HSD) catalyzes the conversion of progesterone to its inactive form 20alpha-dihydroprogesterone (20alpha-OHP).	20alpha-ohp	142-153	aldo-keto reductase family 1, member C18	Mus musculus	0-36
15703459-1	2005	20Alpha-hydroxysteroid dehydrogenase (20alpha-HSD) catalyzes the conversion of progesterone to its inactive form 20alpha-dihydroprogesterone (20alpha-OHP).	20alpha-ohp	142-153	aldo-keto reductase family 1, member C18	Mus musculus	38-49
14967952-1	2003	20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), a member of the aldo-keto reductase (AKR) superfamily, metabolizes progesterone to its inactive form, 20alpha-dihydroprogesterone (20alpha-OHP).	20alpha-ohp	183-194	aldo-keto reductase family 1, member C18	Mus musculus	0-36
14967952-1	2003	20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), a member of the aldo-keto reductase (AKR) superfamily, metabolizes progesterone to its inactive form, 20alpha-dihydroprogesterone (20alpha-OHP).	20alpha-ohp	183-194	aldo-keto reductase family 1, member C18	Mus musculus	38-49
9408251-1	1997	20alpha-Hydroxysteroid dehydrogenase (20alpha-HSD, E.C.1.1.1.149) in rat luteal tissue, which catalyzes conversion of progesterone to a biologically inactive steroid, 20alpha-hydroxypregn-4-ene-3-one (20alpha-OHP), suppresses progesterone secretion into the circulation.	20alpha-ohp	201-212	aldo-keto reductase family 1, member C3	Rattus norvegicus	0-36
9408251-1	1997	20alpha-Hydroxysteroid dehydrogenase (20alpha-HSD, E.C.1.1.1.149) in rat luteal tissue, which catalyzes conversion of progesterone to a biologically inactive steroid, 20alpha-hydroxypregn-4-ene-3-one (20alpha-OHP), suppresses progesterone secretion into the circulation.	20alpha-ohp	201-212	aldo-keto reductase family 1, member C3	Rattus norvegicus	38-49
18667791-1	2008	The enzyme 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) catabolizes progesterone into a biologically inactive steroid, 20alpha-dihydroprogesterone (20alpha-OHP).	20alpha-ohp	154-165	aldo-keto reductase family 1, member C18	Mus musculus	11-47
18667791-1	2008	The enzyme 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) catabolizes progesterone into a biologically inactive steroid, 20alpha-dihydroprogesterone (20alpha-OHP).	20alpha-ohp	154-165	aldo-keto reductase family 1, member C18	Mus musculus	49-60
16338060-5	2006	We first confirmed that AKR1C1 (human 20alpha-hydroxysteroid dehydrogenase) in a cellular context inactivates P by forming 20alpha-OHP but does not catalyze the reverse reaction.	20alpha-ohp	123-134	aldo-keto reductase family 1 member C1	Homo sapiens	24-30
16338060-5	2006	We first confirmed that AKR1C1 (human 20alpha-hydroxysteroid dehydrogenase) in a cellular context inactivates P by forming 20alpha-OHP but does not catalyze the reverse reaction.	20alpha-ohp	123-134	aldo-keto reductase family 1 member C1	Homo sapiens	38-74
10456828-2	1999	It is known that P450(C26) catalyzes the conversion of cholesterol to 26-hydroxycholesterol, which blocks cholesterol utilization in the cell, and that 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) catalyzes the conversion of progesterone to an inactive steroid, 20alpha-dihydroprogesterone (20alpha-OHP).	20alpha-ohp	297-308	aldo-keto reductase family 1, member C3	Rattus norvegicus	152-188
10456828-6	1999	An inhibitor of 20alpha-HSD, STZ26 (D-homo-16-oxa-4-androstene-3,16alpha-dione), was administered at various doses to rats from Day 12 to 20, effectively suppressing the elevation of 20alpha-OHP in a dose-dependent manner but not the depletion of progesterone completely.	20alpha-ohp	183-194	aldo-keto reductase family 1, member C3	Rattus norvegicus	16-27
17323380-10	2007	This is the first study to show that progesterone causes a rapid non-genomic inhibition of plasma membrane NHE1 activity in T cells within minutes which is released by 20alpha-OHP.	20alpha-ohp	168-179	solute carrier family 9 member A1	Homo sapiens	107-111
17323380-11	2007	The inhibition of NHE1 leads to immunosuppressive T-cell proliferation and suggests that progesterone might exert a major rapid non-genomic suppressive effect on NHE1 activity at the maternal-fetal interface in vivo and that 20alpha-OHP may possibly be able to quickly release the suppression when T cells circulated away from the interface.	20alpha-ohp	225-236	solute carrier family 9 member A1	Homo sapiens	18-22
925588-5	1977	It is concluded that 20alpha-hydroxysteroid dehydrogenase activity is present in the immature rat ovary before ovulation and that an increase in the production of testosterone in the ovaries of rats treated with PMSG and HCG precedes increased production of progesterone and 20alpha-OHP in these ovaries.	20alpha-ohp	275-286	aldo-keto reductase family 1, member C3	Rattus norvegicus	21-57