PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11562118-4	2001	AdBMP-7 modification of bovine chondrocytes induced expression of BMP-7 mRNA and bioactive protein, resulting in an increase in incorporation of 35SO4- into proteoglycan, 3H-proline uptake into protein, and the expression of the cartilage-specific matrix genes, aggrecan and type II collagen.	35so4	145-150	bone morphogenetic protein 7	Bos taurus	2-7
11544906-9	2001	The synthesis of proteoglycans (PGS) upon treatment with bone morphogenetic protein (BMP)-2 was measured in cells incubated with BMP-2 for 4 days followed by 35SO4(2-) labeling for 6 hours.	35so4	158-163	bone morphogenetic protein 2	Gallus gallus	57-91
11467840-5	2001	At 7.6 nM, YKL-40 increased the number of cells of 42% in GPC, 75% in RC, and 86% in RS after 72 h. YKL-40 also stimulated total proteoglycan synthesis by chondrocytes in a dose-dependent manner as assessed by Na[35SO4] incorporation and cetylpyridinium chloride precipitation.	35so4	213-218	chitinase 3 like 1	Homo sapiens	11-17
11467840-5	2001	At 7.6 nM, YKL-40 increased the number of cells of 42% in GPC, 75% in RC, and 86% in RS after 72 h. YKL-40 also stimulated total proteoglycan synthesis by chondrocytes in a dose-dependent manner as assessed by Na[35SO4] incorporation and cetylpyridinium chloride precipitation.	35so4	213-218	chitinase 3 like 1	Homo sapiens	100-106
11800014-8	2001	In the absence of beta-glycerophosphate, which is required for optimal mineralization of the bone nodules, 35SO4-labelled BSP was increased in the medium and G1 extract and decreased in the E extract and G2 extract after 3 h. In addition to differences in the tissue compartmentalization of BSP and OPN, these studies indicate that 35SO4 is lost from BSP during mineralization and that isoforms of BSP exist with a selective affinity for the organic and mineral phases.	35so4	107-112	integrin-binding sialoprotein	Rattus norvegicus	122-125
11800014-8	2001	In the absence of beta-glycerophosphate, which is required for optimal mineralization of the bone nodules, 35SO4-labelled BSP was increased in the medium and G1 extract and decreased in the E extract and G2 extract after 3 h. In addition to differences in the tissue compartmentalization of BSP and OPN, these studies indicate that 35SO4 is lost from BSP during mineralization and that isoforms of BSP exist with a selective affinity for the organic and mineral phases.	35so4	107-112	integrin-binding sialoprotein	Rattus norvegicus	291-294
11800014-8	2001	In the absence of beta-glycerophosphate, which is required for optimal mineralization of the bone nodules, 35SO4-labelled BSP was increased in the medium and G1 extract and decreased in the E extract and G2 extract after 3 h. In addition to differences in the tissue compartmentalization of BSP and OPN, these studies indicate that 35SO4 is lost from BSP during mineralization and that isoforms of BSP exist with a selective affinity for the organic and mineral phases.	35so4	107-112	secreted phosphoprotein 1	Rattus norvegicus	299-302
11800014-6	2001	In the G1 extract the 35SO4-labelled BSP decreased with chase time, whereas the 32PO4-labelled BSP increased.	35so4	22-27	integrin-binding sialoprotein	Rattus norvegicus	37-40
11800014-8	2001	In the absence of beta-glycerophosphate, which is required for optimal mineralization of the bone nodules, 35SO4-labelled BSP was increased in the medium and G1 extract and decreased in the E extract and G2 extract after 3 h. In addition to differences in the tissue compartmentalization of BSP and OPN, these studies indicate that 35SO4 is lost from BSP during mineralization and that isoforms of BSP exist with a selective affinity for the organic and mineral phases.	35so4	107-112	integrin-binding sialoprotein	Rattus norvegicus	291-294
11800014-8	2001	In the absence of beta-glycerophosphate, which is required for optimal mineralization of the bone nodules, 35SO4-labelled BSP was increased in the medium and G1 extract and decreased in the E extract and G2 extract after 3 h. In addition to differences in the tissue compartmentalization of BSP and OPN, these studies indicate that 35SO4 is lost from BSP during mineralization and that isoforms of BSP exist with a selective affinity for the organic and mineral phases.	35so4	107-112	integrin-binding sialoprotein	Rattus norvegicus	291-294
11800014-8	2001	In the absence of beta-glycerophosphate, which is required for optimal mineralization of the bone nodules, 35SO4-labelled BSP was increased in the medium and G1 extract and decreased in the E extract and G2 extract after 3 h. In addition to differences in the tissue compartmentalization of BSP and OPN, these studies indicate that 35SO4 is lost from BSP during mineralization and that isoforms of BSP exist with a selective affinity for the organic and mineral phases.	35so4	332-337	integrin-binding sialoprotein	Rattus norvegicus	122-125
9886921-7	1999	The additional transport of 36Cl and 35SO4 had the characteristics of hAE1-mediated transport in erythrocytes: 1) inhibition by 250 microM DNDS, 2) activation of 36Cl efflux by external Cl with a concentration producing half-maximal effect of 4.8 mM, 3) activation of 36Cl efflux by external anions that was selective in the order NO3 = Cl > Br > I, and 4) activation of 35SO4 influx by external protons.	35so4	37-42	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	70-74
10674345-5	2000	Third, CNP stimulates cartilage matrix production as assessed by incorporation of 35SO4 into glycosaminoglycans.	35so4	82-87	natriuretic peptide C	Rattus norvegicus	7-10
10578152-1	1999	1 We investigated whether vasoactive intestinal peptide (VIP) and its related peptides, pituitary adenylate cyclase activating peptide (PACAP) and secretin, regulate cholinergic neural mucus secretion in ferret trachea in vitro, using 35SO4 as a mucus marker.	35so4	235-240	VIP peptides	Mustela putorius furo	57-60
9886921-7	1999	The additional transport of 36Cl and 35SO4 had the characteristics of hAE1-mediated transport in erythrocytes: 1) inhibition by 250 microM DNDS, 2) activation of 36Cl efflux by external Cl with a concentration producing half-maximal effect of 4.8 mM, 3) activation of 36Cl efflux by external anions that was selective in the order NO3 = Cl > Br > I, and 4) activation of 35SO4 influx by external protons.	35so4	37-42	NBL1, DAN family BMP antagonist	Homo sapiens	331-334
9886921-7	1999	The additional transport of 36Cl and 35SO4 had the characteristics of hAE1-mediated transport in erythrocytes: 1) inhibition by 250 microM DNDS, 2) activation of 36Cl efflux by external Cl with a concentration producing half-maximal effect of 4.8 mM, 3) activation of 36Cl efflux by external anions that was selective in the order NO3 = Cl > Br > I, and 4) activation of 35SO4 influx by external protons.	35so4	377-382	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	70-74
10051131-4	1999	Exogenous VIP (1 and 10 microM) alone increased 35SO4 output by up to 53% above baseline, but suppressed (by up to 80% at 1 microM) cholinergic and tachykininergic neural secretion without altering secretion induced by ACh or substance P (1 microM each).	35so4	48-53	VIP peptides	Mustela putorius furo	10-13
9761277-7	1998	When posterior scleral punches were placed in organ culture, 35SO4-labeled proteoglycan turnover rates were similar for control and form-deprived eyes.	35so4	61-66	versican	Gallus gallus	75-87
8755662-4	1996	The ASB vector expressed high levels of enzymatic activity in each of the cell types tested and, in the case of cat and rat cells, enzymatic expression led to complete normalization of 35SO4 incorporation.	35so4	185-190	arylsulfatase B	Rattus norvegicus	4-7
9089441-12	1997	AE1 E699Q-mediated inward current measured in the presence of extracellular Cl- was of magnitude sufficient to account for measured 35SO4(2-) efflux.	35so4	132-137	solute carrier family 4 (anion exchanger), member 1	Mus musculus	0-3
8905627-9	1996	Immunoprecipitation showed a corresponding reduction of 61%, 70% and 65% in the synthesis of 35SO4 labeled basement membrane HSPG by the GEC following 12, 24 and 48 h of incubation with dbcAMP.	35so4	93-98	syndecan 2	Rattus norvegicus	125-129
9242510-4	1997	An antibody for CD44 (Hermes 3) precipitated 7-17% of all 35SO4-labeled proteoglycans (PGs) synthesized in epidermis.	35so4	58-63	CD44 molecule (Indian blood group)	Homo sapiens	16-20
9242510-8	1997	Five to 33% of 35SO4 and 26-37% of [3H]glucosamine, however, was released by endo-beta-galactosidase, implying marked substitution by oligosaccharides with N-acetyllactosamine repeats.	35so4	15-20	galactosidase beta 1	Homo sapiens	82-100
9242510-10	1997	On SDS-polyacrylamide gel electrophoresis, however, western blotting and fluorographs of 35SO4-labeled immunoprecipitates showed the main CD44 isoform at > or = 250 kDa and a shift to 180-200 kDa after heparitinase treatment.	35so4	89-94	CD44 molecule (Indian blood group)	Homo sapiens	138-142
8698830-6	1996	The decrease in mRNA abundance correlated with reduction in the synthesis of 35SO4-labeled basement membrane HSPG as measured by immunoprecipitation.	35so4	77-82	syndecan 2	Rattus norvegicus	109-113
7733656-9	1995	These findings suggest that (a) inhibition of glomerular epithelial cell synthesis of 35SO4-labeled low anionic macromolecules, probably glycoproteins, may be involved in insulin-induced reversal of glomerular hypertrophy seen in early diabetes, and (b) mechanisms other than insulin lack are involved in reduction in the synthesis of glomerular basement membrane HSPG in diabetic nephropathy.	35so4	86-91	syndecan 2	Rattus norvegicus	364-368
7554444-4	1995	These MRL/lpr/lpr sera induced complement-dependent cleavage and release of 35SO4-labeled material containing primarily cell surface heparan sulfate proteoglycans from these cells, and react with heparin (a glycosaminoglycan related to heparan sulfate) by ELISA and liquid-phase competitive inhibition ELISA.	35so4	76-81	Fas (TNF receptor superfamily member 6)	Mus musculus	10-13
7554444-4	1995	These MRL/lpr/lpr sera induced complement-dependent cleavage and release of 35SO4-labeled material containing primarily cell surface heparan sulfate proteoglycans from these cells, and react with heparin (a glycosaminoglycan related to heparan sulfate) by ELISA and liquid-phase competitive inhibition ELISA.	35so4	76-81	Fas (TNF receptor superfamily member 6)	Mus musculus	14-17
7964449-3	1994	Using a metabolic 35SO4(2-) radiolabeling assay or biotinylation of cell surface proteins, we describe here that CD43 are sulfated molecules the glycosylation of which is altered in human immunodeficiency virus type 1 (HIV-1)-infected leukemic T cells of the CEM line.	35so4	18-23	sialophorin	Homo sapiens	113-117
7843243-5	1995	35SO4(2-) incorporation would thus appear to be an appropriate labeling method for CD43 and CD45 visualization.	35so4	0-5	sialophorin	Homo sapiens	83-87
7843243-5	1995	35SO4(2-) incorporation would thus appear to be an appropriate labeling method for CD43 and CD45 visualization.	35so4	0-5	protein tyrosine phosphatase receptor type C	Homo sapiens	92-96
8035198-10	1994	Retinas lacking photoreceptors produced at least five times the amount of 35SO4(2-)-HSPG found in control incubations.	35so4	74-79	syndecan 2	Mus musculus	84-88
8175739-9	1994	In addition, 50% of the 125I-LDL and 30% of the 125I-LPL were degraded within 3 h. After metabolic labeling of THP-1 proteoglycans with 35SO4, > 30% of pericellular heparan sulfate was lost between 2-4 h of the chase period.	35so4	136-141	GLI family zinc finger 2	Homo sapiens	111-116
8504769-6	1993	Injections of bovine insulin into the Ix fish restored body growth parameters to control levels and stimulated cartilage 35SO4 incorporation in a dose-related manner.	35so4	121-126	insulin	Bos taurus	21-28
7512827-5	1994	GlyCAM-1 was metabolically labeled in lymph node organ culture with 35SO4 and a panel of tritiated carbohydrate precursors.	35so4	68-73	glycosylation dependent cell adhesion molecule 1 (pseudogene)	Homo sapiens	0-8
7513156-5	1994	S-nitrosylacetylpenicillamine (SNAP), an organic donor of NO, reversibly mimicked the effect of IL-1 and CAF on 35SO4(2-) incorporation.	35so4	112-117	interleukin 1 beta	Homo sapiens	96-100
7513156-5	1994	S-nitrosylacetylpenicillamine (SNAP), an organic donor of NO, reversibly mimicked the effect of IL-1 and CAF on 35SO4(2-) incorporation.	35so4	112-117	lysine acetyltransferase 2B	Homo sapiens	105-108
8215430-7	1993	A fraction of the 35SO4= which copurified with the cartilage fibronectin and comigrated with it in NaDodSO4-PAGE could be removed by digestion with chondroitinase ABC.	35so4	18-23	fibronectin 1	Homo sapiens	61-72
8172612-5	1994	After labelling of the mast cells in vivo with 35SO4(2-), RMCP-1 was recovered in a macromolecular complex with [35S]heparin proteoglycans.	35so4	47-52	mast cell protease 1-like 1	Rattus norvegicus	58-64
11548222-4	1994	Maintenance of chondrocytes in type II collagen gels increased the percentage 35SO4-labeled proteoglycans reaching equilibrium in the A1D1 or D1 fraction of CsCl density gradient when compared to chondrocytes maintained in polystyrene microwell cultures.	35so4	78-83	collagen type II alpha 1 chain	Gallus gallus	31-47
8294499-4	1994	Expression of syndecan-1 was verified by Northern and immunoblot analysis and immunoprecipitation of 35SO4-labeled proteoglycans.	35so4	101-106	syndecan 1	Rattus norvegicus	14-24
8118432-5	1993	Examination of the sizes of [35SO4]PGs on Sepharose CL-6 beta columns with and without treatment of IL-1 beta shows that the size of non-extractable [35SO4]PG decreases after IL-1 beta treatment.	35so4	150-155	interleukin 1 beta	Homo sapiens	100-109
8118432-5	1993	Examination of the sizes of [35SO4]PGs on Sepharose CL-6 beta columns with and without treatment of IL-1 beta shows that the size of non-extractable [35SO4]PG decreases after IL-1 beta treatment.	35so4	150-155	interleukin 1 beta	Homo sapiens	175-184
8118432-6	1993	Cellulose acetate plate electrophoresis of these [35SO4]PG fractions shows that the distribution of PGs alters after treatment with IL-1 beta.	35so4	50-55	interleukin 1 beta	Homo sapiens	132-141
8334760-2	1993	They enhance the somatomedin activity as measured by the incorporation of 35SO4 into chick embryo cartilages.	35so4	74-79	insulin like growth factor 1	Gallus gallus	17-28
8458871-4	1993	Transient expression of AE2 in a eukaryotic cell line leads to an increase in stilbene inhibitable whole cell 35SO4(2-)-efflux consistent with its function as a plasma membrane anion exchanger.	35so4	110-115	solute carrier family 4 member 2	Homo sapiens	24-27
7686999-8	1993	A polyclonal antiserum against bovine microfibril associated glycoprotein (MAGP) precipitated a [35SO4]-30 kD protein from [35SO4]-labeled MG-63 medium that co-migrated with a band precipitated by mAb 8E6.	35so4	97-102	microfibril associated protein 2	Bos taurus	38-73
7686999-8	1993	A polyclonal antiserum against bovine microfibril associated glycoprotein (MAGP) precipitated a [35SO4]-30 kD protein from [35SO4]-labeled MG-63 medium that co-migrated with a band precipitated by mAb 8E6.	35so4	97-102	microfibril associated protein 2	Bos taurus	75-79
7686999-8	1993	A polyclonal antiserum against bovine microfibril associated glycoprotein (MAGP) precipitated a [35SO4]-30 kD protein from [35SO4]-labeled MG-63 medium that co-migrated with a band precipitated by mAb 8E6.	35so4	124-129	microfibril associated protein 2	Bos taurus	38-73
7686999-8	1993	A polyclonal antiserum against bovine microfibril associated glycoprotein (MAGP) precipitated a [35SO4]-30 kD protein from [35SO4]-labeled MG-63 medium that co-migrated with a band precipitated by mAb 8E6.	35so4	124-129	microfibril associated protein 2	Bos taurus	75-79
1433500-5	1992	N-glycosidase F digestion of 35SO4(2-)-labelled envelope proteins removed virtually all radiolabel from gp160, gp120, and gp41, indicating that sulfate was linked to the carbohydrate chains of the glycoprotein.	35so4	29-34	glutamyl aminopeptidase	Homo sapiens	104-109
8432417-7	1993	IGF-I added in vitro significantly stimulated 35SO4 incorporation by cartilage explants from control and Hx animals, whereas explants from the animals with IDDM were unresponsive.	35so4	46-51	insulin-like growth factor 1	Rattus norvegicus	0-5
8419650-5	1993	The kinetics of release of sulfate upon acid hydrolysis from 35SO4-labeled gp120 indicate that sulfation occurs in a primary sulfate ester linkage.	35so4	61-66	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	75-80
8419650-7	1993	Fragmentation of the gp120-derived 35SO4-labeled glycopeptides by treatment with hydrazine and nitrous acid and subsequent reduction generated galactosyl-anhydromannitol-6-35SO4, which is the expected reaction product from GlcNAc-6-sulfate within a sulfated lactosamine moiety.	35so4	35-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	21-26
1433500-5	1992	N-glycosidase F digestion of 35SO4(2-)-labelled envelope proteins removed virtually all radiolabel from gp160, gp120, and gp41, indicating that sulfate was linked to the carbohydrate chains of the glycoprotein.	35so4	29-34	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	111-116
1510790-2	1992	Following a 1 h labeling period with [35S]methionine or [35SO4], radiolabeled BSP was rapidly lost from the cells and appeared transiently in the culture medium and in a 4 M GuHCl extract (G1) of the mineralized tissue.	35so4	57-62	integrin-binding sialoprotein	Rattus norvegicus	78-81
1510790-9	1992	From the relative incorporation of [35SO4] over the same time period, a time-dependent loss in sulphate from the BSP was evident.	35so4	36-41	integrin-binding sialoprotein	Rattus norvegicus	113-116
1310882-6	1992	PTH also affected matrix production by the growth plate chondrocytes causing a twofold stimulation of proteoglycan synthesis as determined by the rate of 35SO4 incorporated into matrix macromolecules.	35so4	154-159	parathyroid hormone	Gallus gallus	0-3
1426067-18	1992	IRBP was identified as a 35SO4(2-) labeled protein by immunoadsorption from aliquots of the incubation medium.	35so4	25-30	retinol binding protein 3, interstitial	Mus musculus	0-4
1639809-4	1992	The anti-syndecan antibodies immunoprecipitated a large 35SO4-labeled molecule synthesized by cultured rat aortic VSM cells.	35so4	56-61	syndecan 1	Rattus norvegicus	9-17
1744560-6	1991	IGF-I activity, measured by 35SO4 incorporation into oral cartilage explants in vitro, was decreased 50% by hypophysectomy and increased to 200% of intact control levels after injection of 1000 ng tGH/g.	35so4	28-33	IGFI	Bos taurus	0-5
1922008-7	1991	Metabolic labelling studies using 35SO4(2-) with buffalo pituitary minces showed the incorporation of radioactive sulfate into immunoprecipitable PRL-like material.	35so4	34-39	prolactin-like	Bubalus bubalis	146-149
1892842-3	1991	Recombinant fibrinogen containing the gamma" chain incorporated 35SO4 into its chains during biosynthesis, while no incorporation occurred in the protein containing the gamma chain.	35so4	64-69	fibrinogen beta chain	Homo sapiens	12-22
1654330-5	1991	A LPL-binding protein of similar size was obtained after metabolic labeling of the cellular proteoglycans with 35SO4, indicating that the 220-kDa protein is a proteoglycan.	35so4	111-116	lipoprotein lipase	Bos taurus	2-5
1649377-6	1991	Moreover, approximately one-half of the [35SO4] incorporated into E-extract proteins was present in SPP-1, the remainder being incorporated into PGs with smaller amounts associated with BSP.	35so4	41-46	secreted phosphoprotein 1	Homo sapiens	100-105
2005116-5	1991	Here we have directly compared 35SO4-labeled parathyroid chromogranin A from the pig and the cow to determine if these reported differences were tissue or species specific.	35so4	31-36	chromogranin A	Sus scrofa	57-71
1985932-4	1991	Adipocytes cultured with Trans35S-label and tunicamycin produced an LPL species of 52,000 daltons, but tunicamycin abolished the incorporation of 35SO4 into LPL.	35so4	146-151	lipoprotein lipase	Gallus gallus	157-160
1985932-5	1991	This established that 35SO4 was incorporated into an N-linked oligosaccharide of LPL.	35so4	22-27	lipoprotein lipase	Gallus gallus	81-84
1985932-11	1991	The data show that chicken LPL contains two complex and one high mannose N-linked oligosaccharides and that 35SO4 is incorporated into LPL on a GlcNAc residue of a complex oligosaccharide located at Asn-45.	35so4	108-113	lipoprotein lipase	Gallus gallus	27-30
1985932-11	1991	The data show that chicken LPL contains two complex and one high mannose N-linked oligosaccharides and that 35SO4 is incorporated into LPL on a GlcNAc residue of a complex oligosaccharide located at Asn-45.	35so4	108-113	lipoprotein lipase	Gallus gallus	135-138
1688439-8	1990	BP-25 also inhibited basal and IGF-I-stimulated increases in cartilage dry weight, [3H]thymidine incorporation into DNA, and 35SO4 incorporation into proteoglycan.	35so4	125-130	IGF-I	Gallus gallus	31-36
2393908-2	1990	Lectin differently affects 3H and 35SO4 incorporation.	35so4	34-39	galectin 3	Gallus gallus	0-6
2105940-7	1990	Secretion of total and 3H-labeled chromogranin A was about 3- and 7-fold higher, respectively, at 0.5 mM than at 3.0 mM Ca2+, and secretion of 35SO4-labeled chromogranin A was 67-fold higher.	35so4	143-148	chromogranin A	Bos taurus	157-171
1968763-6	1990	In both brain regions, the developmental pattern of 35SO4(2-) incorporation into sulfolipids was closely correlated to the activities of cerebroside sulfotransferase and of arylsulfatase A.	35so4	52-57	arylsulfatase A	Rattus norvegicus	173-188
2668445-8	1989	Incorporation studies with 35SO4 revealed that apo-E was the major sulfated protein in culture media conditioned by CNS glial cells, whereas sulfation of the protein was undetectable in Schwann cell cultures.	35so4	27-32	apolipoprotein E	Rattus norvegicus	47-52
3300363-2	1987	IGF I and II stimulated 35SO4 incorporation into proteoglycans in a dose-dependent manner in both microvessel and pulmonary artery endothelial cells with maximum threefold increases.	35so4	24-29	IGFI	Bos taurus	0-5
2715188-7	1989	When [35SO4]HSPG from confluent cells was added to synchronized cells just as they were released from the second block, a portion of the [35SO4]HSPG was internalized and [35SO4]HS appeared in the nucleus.	35so4	6-11	syndecan 2	Rattus norvegicus	12-16
2715188-7	1989	When [35SO4]HSPG from confluent cells was added to synchronized cells just as they were released from the second block, a portion of the [35SO4]HSPG was internalized and [35SO4]HS appeared in the nucleus.	35so4	6-11	syndecan 2	Rattus norvegicus	144-148
2715188-7	1989	When [35SO4]HSPG from confluent cells was added to synchronized cells just as they were released from the second block, a portion of the [35SO4]HSPG was internalized and [35SO4]HS appeared in the nucleus.	35so4	138-143	syndecan 2	Rattus norvegicus	12-16
2715188-7	1989	When [35SO4]HSPG from confluent cells was added to synchronized cells just as they were released from the second block, a portion of the [35SO4]HSPG was internalized and [35SO4]HS appeared in the nucleus.	35so4	138-143	syndecan 2	Rattus norvegicus	144-148
2715188-7	1989	When [35SO4]HSPG from confluent cells was added to synchronized cells just as they were released from the second block, a portion of the [35SO4]HSPG was internalized and [35SO4]HS appeared in the nucleus.	35so4	138-143	syndecan 2	Rattus norvegicus	12-16
2715188-7	1989	When [35SO4]HSPG from confluent cells was added to synchronized cells just as they were released from the second block, a portion of the [35SO4]HSPG was internalized and [35SO4]HS appeared in the nucleus.	35so4	138-143	syndecan 2	Rattus norvegicus	144-148
2715188-8	1989	However, at mitosis the [35SO4]HS disappeared almost completely from all of the cellular pools, and after mitosis, more of the [35SO4]HSPG was taken up and [35SO4]HS reappeared in the nucleus and remained in the nucleus until the cells divided again.	35so4	128-133	syndecan 2	Rattus norvegicus	134-138
2715188-8	1989	However, at mitosis the [35SO4]HS disappeared almost completely from all of the cellular pools, and after mitosis, more of the [35SO4]HSPG was taken up and [35SO4]HS reappeared in the nucleus and remained in the nucleus until the cells divided again.	35so4	128-133	syndecan 2	Rattus norvegicus	134-138
2523815-5	1989	A large-molecular-weight, 35SO4-labeled molecule copurified with NCAM isolated from these neural cell cultures, and was resistant to chondroitinase ABC treatment, but degraded completely by nitrous acid treatment.	35so4	26-31	neural cell adhesion molecule 1	Homo sapiens	65-69
2951371-9	1987	The amount of [35SO4]HSPG taken up was markedly reduced when the myo-inositol-PO4-releasable [35SO4]HSPG was pretreated with trypsin, thermolysin, alkaline borohydride, or alkaline phosphatase.	35so4	15-20	syndecan 2	Rattus norvegicus	21-25
2951371-5	1987	When 35SO2/4- was added to cell cultures, the total cell surface HSPG increased linearly, but the percentage of the total cell surface [35SO4]HSPG that was released by myo-inositol-PO4 increased with time during the labeling period, reaching a maximum of 65% after 5 h. When cells were labeled for 12 h without insulin in the medium, the maximum amount of cell surface HSPG that was released by myo-inositol-PO4 was reduced to 30%.	35so4	136-141	syndecan 2	Rattus norvegicus	142-146
2951371-5	1987	When 35SO2/4- was added to cell cultures, the total cell surface HSPG increased linearly, but the percentage of the total cell surface [35SO4]HSPG that was released by myo-inositol-PO4 increased with time during the labeling period, reaching a maximum of 65% after 5 h. When cells were labeled for 12 h without insulin in the medium, the maximum amount of cell surface HSPG that was released by myo-inositol-PO4 was reduced to 30%.	35so4	136-141	syndecan 2	Rattus norvegicus	142-146
2951371-9	1987	The amount of [35SO4]HSPG taken up was markedly reduced when the myo-inositol-PO4-releasable [35SO4]HSPG was pretreated with trypsin, thermolysin, alkaline borohydride, or alkaline phosphatase.	35so4	15-20	syndecan 2	Rattus norvegicus	100-104
2951371-6	1987	However, when cells labeled in the absence of insulin were treated with phosphatidylinositol-specific phospholipase C and then myo-inositol-PO4, the release of the cell surface [35SO4]HSPG was increased to 73%.	35so4	178-183	syndecan 2	Rattus norvegicus	184-188
2951371-7	1987	When the [35SO4]HSPG that was released from the cell surface by treatment with myo-inositol-PO4 was added to cultures of unlabeled hepatocytes, it was taken up very rapidly and a portion of the internalized HSPG was converted to free heparan SO4 chains which appeared in the nucleus.	35so4	10-15	syndecan 2	Rattus norvegicus	16-20
2951371-7	1987	When the [35SO4]HSPG that was released from the cell surface by treatment with myo-inositol-PO4 was added to cultures of unlabeled hepatocytes, it was taken up very rapidly and a portion of the internalized HSPG was converted to free heparan SO4 chains which appeared in the nucleus.	35so4	10-15	syndecan 2	Rattus norvegicus	207-211
2951371-9	1987	The amount of [35SO4]HSPG taken up was markedly reduced when the myo-inositol-PO4-releasable [35SO4]HSPG was pretreated with trypsin, thermolysin, alkaline borohydride, or alkaline phosphatase.	35so4	94-99	syndecan 2	Rattus norvegicus	21-25
2951371-9	1987	The amount of [35SO4]HSPG taken up was markedly reduced when the myo-inositol-PO4-releasable [35SO4]HSPG was pretreated with trypsin, thermolysin, alkaline borohydride, or alkaline phosphatase.	35so4	94-99	syndecan 2	Rattus norvegicus	100-104
3801415-9	1986	When the 35SO4(2-)-labeled SGP-2 was digested with Pronase, the free amino acids could be separated by chromatography from the oligosaccharide.	35so4	9-14	clusterin	Homo sapiens	27-32
3097009-4	1986	In the present study, 35SO4 was shown to be incorporated into SP-I and several other proteins of porcine parathyroid tissue incubated in vitro.	35so4	22-27	chromogranin A	Homo sapiens	62-66
3097009-6	1986	Up to 20% of the tyrosine residues in secreted SP-I were labeled with 35SO4.	35so4	70-75	chromogranin A	Homo sapiens	47-51
3097009-10	1986	Extracellular Ca2+ (3 mM) greatly suppressed the secretion of 35SO4-labeled SP-I without affecting the intracellular sulfation of the molecule or the secretion of a minor sulfated protein unrelated to SP-I.	35so4	62-67	chromogranin A	Homo sapiens	76-80
3097009-11	1986	The ratio of incorporated 35SO4 to 3H-amino-acid was greater in secreted SP-I than in tissue SP-I, suggesting that much sulfation of this protein occurred during or just before secretion.	35so4	26-31	chromogranin A	Homo sapiens	73-77
3801415-10	1986	The 35SO4(2-) was shown to be associated with the oligosaccharide portion of SGP-2.	35so4	4-9	clusterin	Homo sapiens	77-82
2426958-5	1986	Substance P (10(-5) M) and VIP (2 X 10(-6) M) added 4 h after labeling each increased greatly the release of 35SO4-labeled macromolecules (SP, 219%; VIP, 180%) above base line.	35so4	109-114	VIP peptides	Mustela putorius furo	27-30
3770097-4	1986	After one day, the major peak of incorporated 35SO4 in medium fraction dAl eluted as a retarded peak (Kav 0.28) on Sepharose CL-2B, whether cells were maintained under serum-free or serum-containing conditions.	35so4	46-51	dal	Drosophila melanogaster	71-74
2940243-1	1986	Schwann cells cocultured with sensory neurons in a serum-free medium accumulate a single species of radiolabeled heparan sulfate proteoglycan (HS-PG) during incubation in medium containing 35SO4.	35so4	189-194	CD44 molecule (Indian blood group)	Homo sapiens	113-141
2940243-1	1986	Schwann cells cocultured with sensory neurons in a serum-free medium accumulate a single species of radiolabeled heparan sulfate proteoglycan (HS-PG) during incubation in medium containing 35SO4.	35so4	189-194	CD44 molecule (Indian blood group)	Homo sapiens	143-148
2940243-12	1986	When 35SO4-labeled cells were used to prepare cytoskeletons approximately 80% of the total HS-PG was recovered in the cytoskeleton fraction.	35so4	5-10	CD44 molecule (Indian blood group)	Homo sapiens	91-96
3818322-10	1986	The 35SO4 incorporation into HS band isolated from the CCl4-damaged liver, as an indicator of HS synthesis, was increased compared with that of the normal liver.	35so4	4-9	chemokine (C-C motif) ligand 4	Mus musculus	55-59
2943303-8	1986	35SO4(2-)-Labeled heparan sulfate chains prepared from the proteoglycan by a beta-elimination reaction were endocytosed with similar kinetics.	35so4	0-5	amyloid beta precursor protein	Homo sapiens	75-81
6206196-4	1984	(3) Insulin also stimulates the incorporation of 35SO4 and (3H)leucine into both chondroitinase-sensitive and chondroitinase-resistant blastemal proteoglycans.	35so4	49-54	insulin	Homo sapiens	4-11
4092860-7	1985	Incorporation of glycosaminoglycans as evaluated by [35SO4]-labelling was reduced by 8% when cells were exposed to growth hormone (2p less than 0.01).	35so4	53-58	somatotropin	Oryctolagus cuniculus	115-129
6206196-5	1984	(4) Insulin increases the uptake of radiolabeled precursors by the blastemata, namely, (3H)leucine, (3H)uridine, 35SO4, (3H)alpha-aminoisobutyrate, and (3H)2-deoxy-D-glucose.	35so4	113-118	insulin	Homo sapiens	4-11
6456047-1	1981	Human serum contains an ultrafiltrable factor which stimulates the somatomedin activity measured by 35SO4 incorporation into pelvic cartilage of chick embryo, this ultrafiltrable factor activates native serum somatomedin or partially purified somatomedin.	35so4	100-105	insulin like growth factor 1	Gallus gallus	67-78
6730853-1	1984	Somatomedin activity is often measured by 35SO4 uptake in pelvic chick embryo cartilage.	35so4	42-47	insulin like growth factor 1	Gallus gallus	0-11
7241014-5	1981	Somatomedin also promoted a significant increase in body-weight velocity and 35SO4(2-) uptake, both responses were between that observed with the lowest dose of bovine GH and control values.	35so4	77-82	insulin like growth factor 1	Bos taurus	0-11
7391723-2	1980	Treatment with bovine growth hormone for 3 and 7 days resulted in growth without significantly increased levels of serum somatomedin-like activity, as detected by in-vitro uptake of 35SO4(2-) into normal rat cartilage; only after treatment for 14 days was somatomedin activity significantly raised.	35so4	182-187	growth hormone	Mus musculus	22-36
16705694-5	2006	35SO4 incorporation into perlecan was three-fourfold higher in the proliferating/hypertrophic zone than the resting zone.	35so4	0-5	heparan sulfate proteoglycan 2	Bos taurus	25-33
107510-1	1979	The effect of somatomedin and cortisol on embryonic chick cartilage in vitro indicates that somatomedin stimulates 35SO4 uptake while cortisol decreases it with no effect on glycosaminoglycan turnover.	35so4	115-120	insulin like growth factor 1	Gallus gallus	92-103
641404-3	1978	CTAP-I from lymphocytes and CTAP-III from platelets markedly stimulated 35SO4= incorporation into chondroitin 4/6 sulfate and dermatan sulfate synthesized by human synovial, dermal, and cartilage connective tissue cells in vitro.	35so4	72-77	pro-platelet basic protein	Homo sapiens	28-36
129482-6	1976	The release of 35SO4 was inhibited by preincubation of elastase and chymotrypsin-like enzyme with human alpha 1-anti-trypsin, or with their specific chloromethyl ketone inactivators, and the action of elastase was also inhibited by a monospecific antiserum to PMN elastase, freed of major serum proteinase inhibitors.	35so4	15-20	elastase, neutrophil expressed	Homo sapiens	55-63
129482-6	1976	The release of 35SO4 was inhibited by preincubation of elastase and chymotrypsin-like enzyme with human alpha 1-anti-trypsin, or with their specific chloromethyl ketone inactivators, and the action of elastase was also inhibited by a monospecific antiserum to PMN elastase, freed of major serum proteinase inhibitors.	35so4	15-20	elastase, neutrophil expressed	Homo sapiens	260-272
1120960-4	1975	Chondromucoprotein synthesis as determined by 35SO4 incorporation into cartilage proteins was significantly inhibited by as little as 2 mug/ml of NGF and markedly inhibited (65-82 percent) by 20 mug/ml.	35so4	46-51	nerve growth factor	Gallus gallus	146-149
21914170-6	2011	RESULTS: CNP reduced NO and PGE2 release and partially restored [3H]-thymidine and 35SO4 incorporation in constructs cultured with IL-1beta.	35so4	83-88	natriuretic peptide C	Homo sapiens	9-12
18545934-7	2008	In most cases, the inhibitors reduced 35SO4 incorporation with IL-1beta.	35so4	38-43	interleukin 1 beta	Bos taurus	63-71
7391723-3	1980	However, treatment for 2 days with bovine growth hormone, bovine prolactin or thyroxine resulted in a dose-dependent increase in in-vivo uptake of 35SO4(2-) into dwarf mouse costal cartilage; growth hormone and thyroxine did not act synergistically.	35so4	147-152	growth hormone	Mus musculus	42-56
7391723-3	1980	However, treatment for 2 days with bovine growth hormone, bovine prolactin or thyroxine resulted in a dose-dependent increase in in-vivo uptake of 35SO4(2-) into dwarf mouse costal cartilage; growth hormone and thyroxine did not act synergistically.	35so4	147-152	prolactin	Bos taurus	65-74
7391723-3	1980	However, treatment for 2 days with bovine growth hormone, bovine prolactin or thyroxine resulted in a dose-dependent increase in in-vivo uptake of 35SO4(2-) into dwarf mouse costal cartilage; growth hormone and thyroxine did not act synergistically.	35so4	147-152	growth hormone	Mus musculus	192-206
7391723-4	1980	Ten days of treatment with growth hormone promoted a dose-dependent increase in both growth (increased weight gain and tail length) and in-vivo of 35SO4(2-).	35so4	147-152	growth hormone	Mus musculus	27-41
7391723-6	1980	Thus, in-vivo uptake of 35SO4(2-) into dwarf mouse costal cartilage provides a sensitive method for detecting a dose-related effect of growth hormone.	35so4	24-29	growth hormone	Mus musculus	135-149
7353540-1	1980	A basic somatomedin preparation results in a 2-fold stimulation of incorporation of both [3H]leucine into protein and 35SO4 into glycosaminoglycans by cultured chick sternal chondrocytes.	35so4	118-123	insulin like growth factor 1	Gallus gallus	8-19
4832058-0	1974	Experimental modification of patterns of cell death and chondrogenesis in insulin-induced micromelia of the developing chick limb: an autoradiographic analysis of 35SO4 uptake into chondroitin sulfate.	35so4	163-168	insulin	Gallus gallus	74-81
21914170-8	2011	This is in contrast to 35SO4 incorporation, which was enhanced with 100 or 1000 nM CNP in the presence and absence of IL-1beta (P < 0.001).	35so4	23-28	natriuretic peptide C	Homo sapiens	83-86
21914170-9	2011	Stimulation by both dynamic compression and CNP and/or the PKGII inhibitor further reduced NO and PGE2 release and restored [3H]-thymidine and 35SO4 incorporation.	35so4	143-148	natriuretic peptide C	Homo sapiens	44-47
21914170-10	2011	In the presence and absence of IL-1beta, the magnitude of stimulation for [3H]-thymidine and 35SO4 incorporation by dynamic compression was dependent on the concentration of CNP and the response was inhibited with the PKGII inhibitor.	35so4	93-98	interleukin 1 beta	Homo sapiens	31-39
21914170-10	2011	In the presence and absence of IL-1beta, the magnitude of stimulation for [3H]-thymidine and 35SO4 incorporation by dynamic compression was dependent on the concentration of CNP and the response was inhibited with the PKGII inhibitor.	35so4	93-98	natriuretic peptide C	Homo sapiens	174-177
17382552-7	2007	RESULTS: A concentration-dependent stimulation of DNA, PG, collagen and NO synthesis was obtained when cells were incubated with ET-1 for 24-h. Eighteen-month old chondrocytes incorporated per microg DNA more [3H]thymidine, 35SO4 and [3H]proline but less NO when challenged with ET-1 than the 1-month old cells.	35so4	224-229	endothelin 1	Homo sapiens	129-133
16046402-5	2005	35SO4(2-) radiolabeling of serglycin-deficient cells demonstrated a dramatic reduction of incorporated label as compared with wild type cells, indicating that serglycin is by far the dominating proteoglycan species produced by the cytotoxic T lymphocyte.	35so4	0-5	serglycin	Mus musculus	27-36
16912414-4	2006	The current data demonstrate that IL-1beta induced nitrite and PGE2 release and inhibited [3H]-thymidine and 35SO4 incorporation.	35so4	109-114	interleukin 1 beta	Homo sapiens	34-42
16046402-5	2005	35SO4(2-) radiolabeling of serglycin-deficient cells demonstrated a dramatic reduction of incorporated label as compared with wild type cells, indicating that serglycin is by far the dominating proteoglycan species produced by the cytotoxic T lymphocyte.	35so4	0-5	serglycin	Mus musculus	159-168
15147953-4	2004	The data presented demonstrate that TGFbeta3 enhanced 35SO4 and [3H]thymidine incorporation and inhibited nitrite release after 48 h of culture when compared to unsupplemented constructs.	35so4	54-59	transforming growth factor beta 3	Homo sapiens	36-44