PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34371464-0	2021	Synthesis and biological evaluation of selective survivin inhibitors derived from the MX-106 hydroxyquinoline scaffold.	Hydroxyquinolines	93-109	baculoviral IAP repeat-containing 5	Mus musculus	49-57
34371464-4	2021	In this report, we describe the design and syntheses of a series of novel selective survivin inhibitors based on the hydroxyquinoline scaffold from our previously reported lead compound MX-106.	Hydroxyquinolines	117-133	baculoviral IAP repeat-containing 5	Mus musculus	84-92
34371464-11	2021	Collectively, results in this study strongly suggest that the hydroxyquinoline scaffold, represented by 12b and our earlier lead compound MX-106, has abilities to selectively target survivin and is promising for further preclinical development.	Hydroxyquinolines	62-78	baculoviral IAP repeat-containing 5	Mus musculus	182-190
33007545-4	2020	Initially, only the hydroxyquinoline-bearing analogs were found to be potent inhibitors in our GroEL/ES-mediated substrate refolding assays; however, subsequent testing in the presence of an E. coli nitroreductase (NfsB) in situ indicated that metabolites of the nitrofuran-bearing analogs were potent GroEL/ES inhibitor pro-drugs.	Hydroxyquinolines	20-36	GroEL	Escherichia coli	95-100
34117818-5	2021	Here, we investigate a newly developed neuroprotective hydroxyquinoline derivative (Q134R) that suppresses NFAT signaling, without inhibiting CN activity.	Hydroxyquinolines	55-71	nuclear factor of activated T-cells 5	Rattus norvegicus	107-111
34163656-5	2021	Previously, we reported the use of an X-ray crystallographic screen of more than 600 fragments to identify small molecule variations on phthalic acid and hydroxyquinoline motifs that bind within the TDP1 catalytic pocket.	Hydroxyquinolines	154-170	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	199-203
33644006-2	2020	These in silico docking results of quinoline and pyridine substrates, with TDO, also provided support for the postulated cis-dihydroxylation of electron-deficient pyridyl rings, to give transient cis-dihydrodiol intermediates and the derived hydroxyquinolines.	Hydroxyquinolines	242-259	tryptophan 2,3-dioxygenase	Homo sapiens	75-78
33531374-0	2021	The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer.	Hydroxyquinolines	4-20	heat shock protein family A (Hsp70) member 5	Homo sapiens	43-48
33531374-5	2021	In this study, we describe the discovery of a series of novel hydroxyquinoline GRP78 inhibitors.	Hydroxyquinolines	62-78	heat shock protein family A (Hsp70) member 5	Homo sapiens	79-84
33007545-4	2020	Initially, only the hydroxyquinoline-bearing analogs were found to be potent inhibitors in our GroEL/ES-mediated substrate refolding assays; however, subsequent testing in the presence of an E. coli nitroreductase (NfsB) in situ indicated that metabolites of the nitrofuran-bearing analogs were potent GroEL/ES inhibitor pro-drugs.	Hydroxyquinolines	20-36	GroEL	Escherichia coli	302-307
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	Hydroxyquinolines	147-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-64
31742995-5	2019	We show that quinolinols were TEAD-binding compounds that augment YAP/TAZ-TEAD activity, which was verified using TEAD reporter assay, RT-qPCR, and RNA-Seq analyses.	Hydroxyquinolines	13-24	yes-associated protein 1	Mus musculus	66-69
31742995-8	2019	The enhancement of YAP activity by quinolinols accelerates the in vivo wound closure in a mouse wound-healing model.	Hydroxyquinolines	35-46	yes-associated protein 1	Mus musculus	19-22
30777439-4	2019	Thus, we screened relevant hydroxyquinoline derivatives for AHR activity using AHR responsive reporter cell lines.	Hydroxyquinolines	27-43	aryl hydrocarbon receptor	Homo sapiens	60-63
30777439-4	2019	Thus, we screened relevant hydroxyquinoline derivatives for AHR activity using AHR responsive reporter cell lines.	Hydroxyquinolines	27-43	aryl hydrocarbon receptor	Homo sapiens	79-82
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	Hydroxyquinolines	147-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-73
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	Hydroxyquinolines	147-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
29068449-0	2017	Heteroleptic complexes via solubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline.	Hydroxyquinolines	147-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-72
27064299-2	2016	A novel, hydroxyquinoline-containing compound, BRD4354, was shown to preferentially inhibit activity of HDAC5 and HDAC9 in vitro.	Hydroxyquinolines	9-25	histone deacetylase 5	Homo sapiens	104-109
27966961-3	2017	Quinolinols are known chelators that can disrupt the BoNT/A metalloprotease zinc-containing active site, thus impeding its proteolysis of the endogenous protein substrate, synaptosomal-associated protein 25 (SNAP-25).	Hydroxyquinolines	0-11	synaptosome associated protein 25	Homo sapiens	172-206
27966961-3	2017	Quinolinols are known chelators that can disrupt the BoNT/A metalloprotease zinc-containing active site, thus impeding its proteolysis of the endogenous protein substrate, synaptosomal-associated protein 25 (SNAP-25).	Hydroxyquinolines	0-11	synaptosome associated protein 25	Homo sapiens	208-215
27966961-6	2017	These quinolinol analogues demonstrated inhibitory activity in a cell-based model for SNAP-25 cleavage and an ex vivo assay for BoNT/A-mediated muscle paralysis.	Hydroxyquinolines	6-16	synaptosome associated protein 25	Homo sapiens	86-93
27064299-2	2016	A novel, hydroxyquinoline-containing compound, BRD4354, was shown to preferentially inhibit activity of HDAC5 and HDAC9 in vitro.	Hydroxyquinolines	9-25	histone deacetylase 9	Homo sapiens	114-119
15333003-8	2004	The results demonstrate the feasibility of masking the cytotoxicity of hydroxyquinoline-based cytotoxins as Co(III) complexes and demonstrate the utility of cyclen-based auxiliary ligands for optimizing radiolytic activation of these novel prodrugs under hypoxia.	Hydroxyquinolines	71-87	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	108-115
26676770-12	2015	Here, we report the discovery of a hydroxyquinoline family of small molecules that can activate IRF3 to promote cellular antiviral responses.	Hydroxyquinolines	35-51	interferon regulatory factor 3	Homo sapiens	96-100
26298549-6	2015	The derivatives have significant antioxidant capacity and the powerful activity in inhibiting self-induced amyloid-beta aggregation seems to be led by synergistic effects of both cyclodextrin and hydroxyquinoline.	Hydroxyquinolines	196-212	amyloid beta precursor protein	Homo sapiens	107-119
23993674-0	2013	Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.	Hydroxyquinolines	0-16	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	63-68
16789731-2	2006	This quinolinol binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.	Hydroxyquinolines	5-15	transformed mouse 3T3 cell double minute 2	Mus musculus	25-29
16789731-2	2006	This quinolinol binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.	Hydroxyquinolines	5-15	transformation related protein 53, pseudogene	Mus musculus	64-67
16789731-2	2006	This quinolinol binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.	Hydroxyquinolines	5-15	transformed mouse 3T3 cell double minute 2	Mus musculus	141-145
16789731-2	2006	This quinolinol binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.	Hydroxyquinolines	5-15	transformation related protein 53, pseudogene	Mus musculus	146-149
27152771-3	2016	Herein, we introduce a novel conjugated polymer (CP), hydroxyquinoline appended polyfluorene (PF-HQ), which has a typical "amyloid like" surface motif and exhibits inhibitory modulation effect on amyloid beta (Abeta) aggregation.	Hydroxyquinolines	54-70	amyloid beta precursor protein	Homo sapiens	196-208
23747388-0	2013	Photo-physics study of an hydroxy-quinoline derivative as inhibitor of Pim-1 kinase: ultraviolet-visible linear dichroism spectroscopy and quantum chemical calculations.	Hydroxyquinolines	26-43	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	71-76
23297700-0	2013	Binding of hydroxyquinoline probes to human serum albumin: combining molecular modeling and Forster"s resonance energy transfer spectroscopy to understand flexible ligand binding.	Hydroxyquinolines	11-27	albumin	Homo sapiens	44-57