PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33836342-0	2021	Phenylpropanoid-conjugated pentacyclic triterpenoids from the whole plants of Leptopus lolonum induced cell apoptosis via MAPK and Akt pathways in human hepatocellular carcinoma cells.	Triterpenes	39-52	AKT serine/threonine kinase 1	Homo sapiens	131-134
650413-2	1978	Paraffins and triterpenes of Quercus spp.	Triterpenes	14-25	histocompatibility minor 13	Homo sapiens	37-40
1033997-1	1976	V. Paraffins and triterpenes of Quercus spp.	Triterpenes	17-28	histocompatibility minor 13	Homo sapiens	40-43
4204877-0	1973	[Triterpenes of Embelia concinna Bak.	Triterpenes	1-12	BCL2 antagonist/killer 1	Homo sapiens	33-36
33845383-4	2021	In order to discover proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, fourteen new triterpenoid saponins named gypenoside LXXXVIII-CI (1-14) along with six known compounds (15-20) were isolated from G. pentaphyllum.	Triterpenes	100-112	proprotein convertase subtilisin/kexin type 9	Homo sapiens	68-73
34029542-1	2021	Ganoderic acid A (GAA), one of the major triterpenoid components extracted from Ganoderma mushroom has been shown to possess numerous important pharmacological activities.	Triterpenes	41-53	glucosidase, alpha, acid	Mus musculus	18-21
32608254-1	2021	This study aimed to evaluate the effect Cycloastragenol (CAG), a triterpenoid saponin isolated from the Radix astragali, on Abeta-induced BBB damage.	Triterpenes	65-77	histocompatibility 2, class II antigen A, beta 1	Mus musculus	124-129
33567783-1	2021	Semi-synthetic triterpenoids, holding an amino substituted seven-membered A-ring (azepano-ring), which could be synthesized from triterpenic oximes through a Beckmann type rearrangement followed by a reduction of lactame fragment, are considered to be novel promising agents exhibiting anti-microbial, alpha-glucosidase, and butyrylcholinesterase inhibitory activities.	Triterpenes	15-28	sucrase-isomaltase	Homo sapiens	302-319
33658229-11	2021	In conclusion, our results indicate that both P. cocos extract and its major triterpenes are competitive inhibitors of ASBT and NTCP.	Triterpenes	77-88	solute carrier family 10 (sodium/bile acid cotransporter), member 1 L homeolog	Xenopus laevis	128-132
33616937-3	2021	Loss-of-function of the NOVEL INTERACTOR OF JAZ (NINJA), a core component of the JA signaling pathway, leads to enhanced triterpene biosynthesis, in particular of the thalianol gene cluster, in Arabidopsis thaliana roots.	Triterpenes	121-131	Putative interactor of JAZ	Arabidopsis thaliana	24-47
33616795-9	2021	We found that two triterpenes 16-hydroxy-alisol B 23-acetate and alisol M 23-acetate showed favorable ADMET properties and high binding affinity against LXRbeta.	Triterpenes	18-29	nuclear receptor subfamily 1 group H member 3	Homo sapiens	153-160
33991607-3	2021	The synthetic triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im), is a potent Nrf2 activator.	Triterpenes	14-26	NFE2 like bZIP transcription factor 2	Rattus norvegicus	100-104
33964283-5	2021	Both RAB and TA, triterpenoids of traditional medicinal plant Ilex kaushue, selectively inhibited reactive oxygen species production, elastase release, and CD11b expression in human neutrophils activated by FPR1, but not non-FPR1 agonists.	Triterpenes	17-30	ArfGAP with FG repeats 1	Homo sapiens	5-8
33964283-11	2021	Accordingly, triterpenoids RAB and TA represent novel FPR1 antagonists and exhibit therapeutic potential for treating neutrophilic inflammatory skin diseases.	Triterpenes	13-26	ArfGAP with FG repeats 1	Homo sapiens	27-30
33964283-11	2021	Accordingly, triterpenoids RAB and TA represent novel FPR1 antagonists and exhibit therapeutic potential for treating neutrophilic inflammatory skin diseases.	Triterpenes	13-26	formyl peptide receptor 1	Homo sapiens	54-58
33652057-11	2021	Specifically, numerous NPs including flavonoids, gingerols, tannins, anthocyanins, triterpenes and alkaloids have been shown anti-inflammatory, antioxidant, anti-amyloidogenic, and anti-choLinesterase properties.	Triterpenes	83-94	butyrylcholinesterase	Homo sapiens	186-200
33607208-4	2021	Based on this, we developed a Fluorescence Resonance Energy Transfer (FRET) assay and identified three Schisandraceae triterpenoids, including PC3-15, to block HECTD3/UbcH5b auto-ubiquitination.	Triterpenes	118-131	HECT domain E3 ubiquitin protein ligase 3	Mus musculus	160-166
33321190-0	2021	Triterpenoid saponins from Ilex cornuta protect H9c2 cardiomyocytes against H2O2-induced apoptosis by modulating Ezh2 phosphorylation.	Triterpenes	0-12	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	113-117
33404014-10	2021	Additionally, two triterpenoids purified from extracts of oakwood were identified for the first time as potent PL inhibitors demonstrating 51 and 58% inhibition at 1 mg mL-1, respectively.	Triterpenes	18-31	L1 cell adhesion molecule	Mus musculus	169-173
32980486-2	2021	Ginsenoside Rb1 (Rb1) is the most abundant triterpenoid saponin in Panax quinquefolius L., which has the function of Qi-invigorating and Yin-nourishing.	Triterpenes	43-55	RB transcriptional corepressor 1	Homo sapiens	12-15
32980486-2	2021	Ginsenoside Rb1 (Rb1) is the most abundant triterpenoid saponin in Panax quinquefolius L., which has the function of Qi-invigorating and Yin-nourishing.	Triterpenes	43-55	RB transcriptional corepressor 1	Homo sapiens	17-20
33567783-1	2021	Semi-synthetic triterpenoids, holding an amino substituted seven-membered A-ring (azepano-ring), which could be synthesized from triterpenic oximes through a Beckmann type rearrangement followed by a reduction of lactame fragment, are considered to be novel promising agents exhibiting anti-microbial, alpha-glucosidase, and butyrylcholinesterase inhibitory activities.	Triterpenes	15-28	butyrylcholinesterase	Homo sapiens	325-346
33278391-0	2021	Inhibition of breast cancer stem-like cells by a triterpenoid, ursolic acid, via activation of Wnt antagonist, sFRP4 and suppression of miRNA-499a-5p.	Triterpenes	49-61	secreted frizzled related protein 4	Homo sapiens	111-116
33427588-3	2021	In this present study, we have predicted the reported bioactive flavonoids and triterpenoids of the plant against the SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp), spike protein, angiotensin converting enzyme (ACE-2) receptor and dipeptidyl peptidase (DPP4) receptor through molecular docking and in silico ADME predictions methods.	Triterpenes	79-92	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	174-178
33427588-3	2021	In this present study, we have predicted the reported bioactive flavonoids and triterpenoids of the plant against the SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp), spike protein, angiotensin converting enzyme (ACE-2) receptor and dipeptidyl peptidase (DPP4) receptor through molecular docking and in silico ADME predictions methods.	Triterpenes	79-92	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	181-186
33427588-3	2021	In this present study, we have predicted the reported bioactive flavonoids and triterpenoids of the plant against the SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp), spike protein, angiotensin converting enzyme (ACE-2) receptor and dipeptidyl peptidase (DPP4) receptor through molecular docking and in silico ADME predictions methods.	Triterpenes	79-92	angiotensin I converting enzyme	Homo sapiens	196-225
33427588-3	2021	In this present study, we have predicted the reported bioactive flavonoids and triterpenoids of the plant against the SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp), spike protein, angiotensin converting enzyme (ACE-2) receptor and dipeptidyl peptidase (DPP4) receptor through molecular docking and in silico ADME predictions methods.	Triterpenes	79-92	dipeptidyl peptidase 4	Homo sapiens	269-273
33149812-0	2020	Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1alpha Signaling Pathways Mediated by the NAMPT-NAD Pathway.	Triterpenes	17-28	forkhead box O3	Homo sapiens	85-91
32755651-2	2020	Ganoderic acid D (GAD) as a representative active triterpenoid from Ganoderma lucidum is known to possess anticancer activity.	Triterpenes	50-62	glutamate decarboxylase 1	Homo sapiens	0-16
33378324-1	2020	It is now clear that the photomicrographs in Figure 2 are duplicates of the same image and that Figures 4 and 5 have been "copied" from a publication "Lupeol triterpene exhibits potent antitumor effects in A427 human lung carcinoma cells via mitochondrial mediated apoptosis, ROS generation, loss of mitochondrial membrane potential and downregulation of m-TOR/PI3Ksol;AKT signalling pathway" by Wei He, Xiang Li, Shuyue Xia, PMID: 30003730.	Triterpenes	158-168	RAR related orphan receptor C	Homo sapiens	357-360
33378324-1	2020	It is now clear that the photomicrographs in Figure 2 are duplicates of the same image and that Figures 4 and 5 have been "copied" from a publication "Lupeol triterpene exhibits potent antitumor effects in A427 human lung carcinoma cells via mitochondrial mediated apoptosis, ROS generation, loss of mitochondrial membrane potential and downregulation of m-TOR/PI3Ksol;AKT signalling pathway" by Wei He, Xiang Li, Shuyue Xia, PMID: 30003730.	Triterpenes	158-168	AKT serine/threonine kinase 1	Homo sapiens	369-372
33303817-8	2020	Derivatives of the birch-derived pentacyclic lupane-type triterpenoid betulin revealed clear NTCP inhibitory potency and selectivity for the virus receptor function of NTCP.	Triterpenes	57-69	solute carrier family 10 member 1	Homo sapiens	93-97
33303817-8	2020	Derivatives of the birch-derived pentacyclic lupane-type triterpenoid betulin revealed clear NTCP inhibitory potency and selectivity for the virus receptor function of NTCP.	Triterpenes	57-69	solute carrier family 10 member 1	Homo sapiens	168-172
33136399-3	2020	Using molecular docking and dynamics, this difference was translated into distinct accommodation modes at the TRPV1 vanillyl ligand pocket, suggesting a critical role of a C-H piphenyl interaction between the triterpenoid C-29 methyl and Phe591 of TRPV1.	Triterpenes	209-221	transient receptor potential cation channel subfamily V member 1	Homo sapiens	110-115
33136399-3	2020	Using molecular docking and dynamics, this difference was translated into distinct accommodation modes at the TRPV1 vanillyl ligand pocket, suggesting a critical role of a C-H piphenyl interaction between the triterpenoid C-29 methyl and Phe591 of TRPV1.	Triterpenes	209-221	transient receptor potential cation channel subfamily V member 1	Homo sapiens	248-253
32926144-0	2020	Revisiting the action of steroids and triterpenoids on the human sperm Ca2+ channel CatSper.	Triterpenes	38-51	cation channel sperm associated 1	Homo sapiens	84-91
32926144-3	2020	This aim of this study was to elucidate this controversy by investigating the action of these steroids and plant triterpenoids on human CatSper using population based Ca2+-fluorimetric measurements, the specific CatSper inhibitor RU1968, and a functional test assessing the CatSper-dependent penetration of human sperm cells into methylcellulose.	Triterpenes	113-126	cation channel sperm associated 1	Homo sapiens	136-143
33195060-4	2020	By combining an in silico approach and molecular in vitro testing we have been able to identify several triterpenoid/steroidal agents that inhibit interaction of the Spike RBD with the carboxypeptidase domain of the Angiotensin Converting Enzyme (ACE2).	Triterpenes	104-116	angiotensin I converting enzyme	Homo sapiens	216-245
33195060-4	2020	By combining an in silico approach and molecular in vitro testing we have been able to identify several triterpenoid/steroidal agents that inhibit interaction of the Spike RBD with the carboxypeptidase domain of the Angiotensin Converting Enzyme (ACE2).	Triterpenes	104-116	angiotensin converting enzyme 2	Homo sapiens	247-251
33149812-0	2020	Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1alpha Signaling Pathways Mediated by the NAMPT-NAD Pathway.	Triterpenes	17-28	superoxide dismutase 2	Homo sapiens	92-97
33149812-0	2020	Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1alpha Signaling Pathways Mediated by the NAMPT-NAD Pathway.	Triterpenes	17-28	PPARG coactivator 1 alpha	Homo sapiens	98-108
33149812-0	2020	Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1alpha Signaling Pathways Mediated by the NAMPT-NAD Pathway.	Triterpenes	17-28	nicotinamide phosphoribosyltransferase	Homo sapiens	144-149
32768650-8	2020	In this case, the nanoencapsulated triterpene was more selective to PC3 (SI 3.33) and SNB19 (SI 4.54) tumor cells.	Triterpenes	35-45	chromobox 8	Homo sapiens	68-71
32840371-0	2020	Lanostane Triterpenoids with PTP1B Inhibitory and Glucose-Uptake Stimulatory Activities from Mushroom Fomitopsis pinicola Collected in North America.	Triterpenes	10-23	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	29-34
32632601-3	2020	In this sense, in this report a computational model of linear prediction of acetylcholinesterase inhibitory activity of steroids and triterpenes is presented.	Triterpenes	133-144	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-96
32943612-0	2020	The triterpenoid sapogenin (2alpha-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling.	Triterpenes	4-16	nuclear receptor subfamily 1, group H, member 4	Mus musculus	105-108
32943612-0	2020	The triterpenoid sapogenin (2alpha-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling.	Triterpenes	4-16	glucagon	Mus musculus	109-114
32314397-4	2020	This review aims to provide an integrative description on how pentacyclic triterpenes can effectively treat calcium oxalate urolithiasis through various mechanisms such as antioxidant, anti-inflammatory, diuretic, and angiotensin-converting enzyme inhibition.	Triterpenes	74-85	angiotensin I converting enzyme	Homo sapiens	218-247
32534078-0	2020	Oleanolic acid induces a dual agonist action on PPARgamma/alpha and GLUT4 translocation: A pentacyclic triterpene for dyslipidemia and type 2 diabetes.	Triterpenes	103-113	peroxisome proliferator activated receptor gamma	Homo sapiens	48-63
32534078-0	2020	Oleanolic acid induces a dual agonist action on PPARgamma/alpha and GLUT4 translocation: A pentacyclic triterpene for dyslipidemia and type 2 diabetes.	Triterpenes	103-113	solute carrier family 2 member 4	Homo sapiens	68-73
32787104-1	2020	Synthetic triterpenoids including CDDO, its methyl ester (CDDO-Me, bardoxolone methyl), and its imidazolide (CDDO-Im) enhance Nrf2-mediated anti-oxidant and anti-inflammatory activity in many diseases by reacting with thiols on the adaptor protein, Keap1.	Triterpenes	10-23	NFE2 like bZIP transcription factor 2	Homo sapiens	126-130
32787104-1	2020	Synthetic triterpenoids including CDDO, its methyl ester (CDDO-Me, bardoxolone methyl), and its imidazolide (CDDO-Im) enhance Nrf2-mediated anti-oxidant and anti-inflammatory activity in many diseases by reacting with thiols on the adaptor protein, Keap1.	Triterpenes	10-23	kelch like ECH associated protein 1	Homo sapiens	249-254
32717961-0	2020	Acyclic Triterpenoid Isolated from Alpinia katsumadai Alleviates Formalin-Induced Chronic Mouse Paw Inflammation by Inhibiting the Phosphorylation of ERK and NF-kappaB.	Triterpenes	8-20	mitogen-activated protein kinase 1	Mus musculus	150-153
32689796-5	2020	Based on a test of 12 typical natural products, GmSGT2 showed high specificity toward the pentacyclic triterpenoid skeleton as the sugar acceptor.	Triterpenes	102-114	soyasapogenol B glucuronide galactosyltransferase	Glycine max	48-54
32569471-8	2020	Noroleanane triterpenoids 1-4 had potential neuroprotective and anti-inflammatory effects against Abeta-induced neuronal damage.	Triterpenes	12-25	amyloid beta (A4) precursor protein	Mus musculus	98-103
32291806-13	2020	These data suggest that the selected members of the triterpene family (such as lupeol) could be exploited as clinical agents for preventing the disease progression in KRAS-driven cancers which however warrants further investigation.	Triterpenes	52-62	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	167-171
32717961-0	2020	Acyclic Triterpenoid Isolated from Alpinia katsumadai Alleviates Formalin-Induced Chronic Mouse Paw Inflammation by Inhibiting the Phosphorylation of ERK and NF-kappaB.	Triterpenes	8-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-167
32274681-1	2020	The article Cycloartane triterpenoid (23R, 24E)-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both beta-catenin.	Triterpenes	24-36	catenin beta 1	Homo sapiens	187-199
32696666-4	2022	The stereochemical and substitutional array trans, syn, trans, anti, trans, anti, trans for the A-E rings of the triterpene totaiol (1) is not known, and therefore, its biosynthetic significance as an important intermediate should be emphasized.	Triterpenes	113-123	synemin	Homo sapiens	51-54
32595508-4	2020	A dichloromethane extract (OS1), mainly composed of isoflavonoids and triterpenes as characterized by LC-MS, showed a concentration-dependent (25-100 mug/ml) inhibition of IL-8 and TNF-alpha release from LPS-stimulated human neutrophils.	Triterpenes	70-81	frizzled related protein	Homo sapiens	27-30
32595508-4	2020	A dichloromethane extract (OS1), mainly composed of isoflavonoids and triterpenes as characterized by LC-MS, showed a concentration-dependent (25-100 mug/ml) inhibition of IL-8 and TNF-alpha release from LPS-stimulated human neutrophils.	Triterpenes	70-81	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
32595508-4	2020	A dichloromethane extract (OS1), mainly composed of isoflavonoids and triterpenes as characterized by LC-MS, showed a concentration-dependent (25-100 mug/ml) inhibition of IL-8 and TNF-alpha release from LPS-stimulated human neutrophils.	Triterpenes	70-81	tumor necrosis factor	Homo sapiens	181-190
32058036-0	2020	Triglyceride deficiency and diacylglycerol kinase1 activity lead to the upregulation of mevalonate pathway in yeast: A study for the development of potential yeast platform for improved production of triterpenoid.	Triterpenes	200-212	diacylglycerol kinase	Saccharomyces cerevisiae S288C	28-50
31732915-3	2020	This study aims to validate the effect of NDRG2-targeted therapy using structurally related bioactive triterpene compounds derived from the edible mushroom Ganoderma lucidum (ganoderic acid A:GA-A/ganoderic acid DM:GA-DM) in human AM in relevant pre-clinical models.	Triterpenes	102-112	NDRG family member 2	Homo sapiens	42-47
32575028-1	2020	BACKGROUND: P. chinensis saponins (PRS) are pentacyclic triterpenoid bioactive constituents from Pulsatilla chinensis (Bunge) Regel.	Triterpenes	56-68	PRS	Homo sapiens	35-38
31981603-0	2020	Natural triterpenoid saponin Momordin Ic suppresses HepG2 cell invasion via COX-2 inhibition and PPARgamma activation.	Triterpenes	8-20	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
31981603-0	2020	Natural triterpenoid saponin Momordin Ic suppresses HepG2 cell invasion via COX-2 inhibition and PPARgamma activation.	Triterpenes	8-20	peroxisome proliferator activated receptor gamma	Homo sapiens	97-106
32372868-10	2020	All these findings indicate PPD as a small molecular activator of CK-MM, which can help in further developing better CK-MM activators based on the dammarane-type triterpenoid structure.	Triterpenes	162-174	creatine kinase, muscle	Mus musculus	66-71
32372868-10	2020	All these findings indicate PPD as a small molecular activator of CK-MM, which can help in further developing better CK-MM activators based on the dammarane-type triterpenoid structure.	Triterpenes	162-174	creatine kinase, muscle	Mus musculus	117-122
31940436-4	2020	To alter flux from predominant triterpenoid/steroid biosynthesis to sesquiterpenoid production, expression of ERG9 (encoding yeast squalene synthase) was depressed by replacing its innate promotor with PHXT1 and fermenting the resulting strains in galactose-rich media.	Triterpenes	31-43	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	110-114
31863472-0	2020	Total triterpenes from the fruits of Chaenomeles speciosa (Sweet) Nakai protects against indomethacin-induced gastric mucosal injury: involvement of TFF1-mediated EGF/EGFR and apoptotic pathways.	Triterpenes	6-17	trefoil factor 1	Rattus norvegicus	149-153
31863472-0	2020	Total triterpenes from the fruits of Chaenomeles speciosa (Sweet) Nakai protects against indomethacin-induced gastric mucosal injury: involvement of TFF1-mediated EGF/EGFR and apoptotic pathways.	Triterpenes	6-17	epidermal growth factor	Rattus norvegicus	163-166
31863472-0	2020	Total triterpenes from the fruits of Chaenomeles speciosa (Sweet) Nakai protects against indomethacin-induced gastric mucosal injury: involvement of TFF1-mediated EGF/EGFR and apoptotic pathways.	Triterpenes	6-17	epidermal growth factor receptor	Rattus norvegicus	167-171
31911265-0	2020	Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3K-AKT related signal pathway in SMMC7721 cancer cells.	Triterpenes	0-13	AKT serine/threonine kinase 1	Homo sapiens	73-76
32320433-4	2020	NFE2L2 is activated by the novel triterpenoid RS9 (a biotransformation compound of RTA 402).	Triterpenes	33-45	NFE2 like bZIP transcription factor 2	Homo sapiens	0-6
32097779-5	2020	PURPOSE: To explore the anticancer mechanism of action of the triterpenoid alkaloid KBA01 compound by targeting mutant p53 degradation.	Triterpenes	62-74	tumor protein p53	Homo sapiens	119-122
32099450-0	2020	Vitellaria paradoxa Nut Triterpene-Rich Extract Ameliorates Symptoms of Inflammation on Post-Traumatic Osteoarthritis in Obese Rats.	Triterpenes	24-34	NUT midline carcinoma, family member 1	Rattus norvegicus	20-23
32099450-5	2020	The level of nitric oxide, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha decreased after treatment with VP nut triterpene-rich extract, especially in high-doses.	Triterpenes	127-137	NUT midline carcinoma, family member 1	Rattus norvegicus	123-126
32110017-1	2020	Background: Celastrol (CEL), a triterpene extracted from the Chinese herb tripterygium wilfordii, has been reported to have profound anticancer activities.	Triterpenes	31-41	carboxyl ester lipase	Mus musculus	23-26
32099450-4	2020	Results: The VP nut triterpene-rich extract decreased the level of triglycerides and increased high-density lipoprotein-cholesterol.	Triterpenes	20-30	NUT midline carcinoma, family member 1	Rattus norvegicus	16-19
32099450-6	2020	The VP nut triterpene-rich extracts also alleviated swelling in the knee OA, weight-bearing difference, and suppressed cartilage degradation.	Triterpenes	11-21	NUT midline carcinoma, family member 1	Rattus norvegicus	7-10
32099450-7	2020	Conclusion: The Vitellaria paradoxa nut triterpene-rich extract suppressed proinflammatory mediators and attenuated the cartilage degradation and pain in osteoarthritis with an obesity rat model.	Triterpenes	40-50	NUT midline carcinoma, family member 1	Rattus norvegicus	36-39
31505326-0	2020	The dietary triterpenoid 18alpha-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway.	Triterpenes	12-24	mitogen-activated protein kinase 1	Homo sapiens	104-107
32099450-8	2020	As such, Vitellaria paradoxa nut triterpene-rich extract can be used as an alternative for osteoarthritis treatment.	Triterpenes	33-43	NUT midline carcinoma, family member 1	Rattus norvegicus	29-32
31780304-5	2020	This study provides structural insight of the interactions between these pentacyclic triterpenoid 3beta-ester derivatives and CETP protein for the further modification and optimization.	Triterpenes	85-97	cholesteryl ester transfer protein	Homo sapiens	126-130
31017233-9	2020	Preliminary phytochemical screening showed that the Sc-Hex and the Sc-CHCl3 were positive for the presence of flavonoids, anthracene derivatives, quinones, triterpenes and steroids.	Triterpenes	156-167	hematopoietically expressed homeobox	Mus musculus	55-58
31505326-0	2020	The dietary triterpenoid 18alpha-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway.	Triterpenes	12-24	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
31505326-1	2020	18alpha-Glycyrrhetinic acid (18alpha-GA) is a bioactive triterpenoid that has been shown to activate the nuclear factor (erythroid-derived-2)-like 2 (Nrf2), the main transcription factor that orchestrates the cellular antioxidant response, in both cellular and organismal context.	Triterpenes	56-68	NFE2 like bZIP transcription factor 2	Homo sapiens	105-148
31505326-1	2020	18alpha-Glycyrrhetinic acid (18alpha-GA) is a bioactive triterpenoid that has been shown to activate the nuclear factor (erythroid-derived-2)-like 2 (Nrf2), the main transcription factor that orchestrates the cellular antioxidant response, in both cellular and organismal context.	Triterpenes	56-68	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
31078628-6	2019	For this review, we collected and analyzed all of the UGT sequences found in Arabidopsis thaliana as well as 31 other species of triterpene-producing plants.	Triterpenes	129-139	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	54-57
31442708-0	2019	Influence of functional moiety in lupane-type triterpenoids in BACE1 inhibition.	Triterpenes	46-59	beta-secretase 1	Homo sapiens	63-68
31078628-8	2019	We highlight recent findings on UGT inducibility by methyl jasmonate, tissue-specific expression, and subcellular localization, while also describing their catalytic activity in terms of regioselectivity for potential key UGTs dedicated to triterpene glycosylation in plants.	Triterpenes	240-250	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	32-35
31635144-1	2019	Strain GA A07 was identified as an intestinal Bacillus bacterium of zebrafish, which has high efficiency to biotransform the triterpenoid, ganoderic acid A (GAA), into GAA-15-O-beta-glucoside.	Triterpenes	125-137	alpha glucosidase	Danio rerio	157-160
31635144-1	2019	Strain GA A07 was identified as an intestinal Bacillus bacterium of zebrafish, which has high efficiency to biotransform the triterpenoid, ganoderic acid A (GAA), into GAA-15-O-beta-glucoside.	Triterpenes	125-137	alpha glucosidase	Danio rerio	168-171
31635144-9	2019	The suitable conditions for this enzyme activity were pH 7.5, 10 mM of magnesium ions, and 30  C. In addition, BtGT_16345 showed glycosylation activity toward seven flavonoids (apigenein, quercetein, naringenein, resveratrol, genistein, daidzein, and 8-hydroxydaidzein) and two triterpenoids (GAA and antcin K).	Triterpenes	278-291	alpha glucosidase	Danio rerio	293-296
31635144-11	2019	In short, this study identified BtGT_16345 from B. thuringiensis GA A07 is the catalytic enzyme responsible for the 15-O-glycosylation of GAA and it was also regioselective toward triterpenoid substrates.	Triterpenes	180-192	alpha glucosidase	Danio rerio	138-141
31547018-0	2019	HMGB1-triggered inflammation inhibition of notoginseng leaf triterpenes against cerebral ischemia and reperfusion injury via MAPK and NF-kappaB signaling pathways.	Triterpenes	60-71	high mobility group box 1	Homo sapiens	0-5
31614687-7	2019	The expressions of crucial genes (bAS and CHS), key enzymes of triterpenoid and flavonoid synthesis, were also tested by qRT-PCR.	Triterpenes	63-75	lysosomal trafficking regulator	Homo sapiens	42-45
31574910-6	2019	Cytotoxicity of the parent triterpenes and the synthesized compounds against CML cell line K562 was examined; revealing three promising compounds PT5, GP2 and GP5 (IC50 5.46, 4.78 and 3.19 muM, respectively).	Triterpenes	27-38	glycoprotein V platelet	Homo sapiens	159-162
31487883-6	2019	Proteomics analysis of Nicotiana benthamiana leaves expressing p22, and its F-box-like motif deletion mutant showed 228 differentially expressed proteins and five enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways: ABC transporters, sesquiterpenoid and triterpenoid biosynthesis, ubiquitin-mediated proteolysis, riboflavin metabolism, and cysteine and methionine metabolism.	Triterpenes	267-279	calcineurin like EF-hand protein 1	Homo sapiens	63-66
31132532-2	2019	Our previous work found that celastrol, a pentacyclic triterpene, bound to Nur77 to inhibit inflammation in a Nur77-dependent manner.	Triterpenes	54-64	nuclear receptor subfamily 4 group A member 1	Homo sapiens	75-80
31132532-2	2019	Our previous work found that celastrol, a pentacyclic triterpene, bound to Nur77 to inhibit inflammation in a Nur77-dependent manner.	Triterpenes	54-64	nuclear receptor subfamily 4 group A member 1	Homo sapiens	110-115
31222655-7	2019	The results showed that Ganoderma lucidum triterpenoids could reduce the content of Cd and MDA; increase the antioxidant enzyme activities (SOD and GSH-Px); decrease the expression of inflammatory factors (TNF-alpha) and interleukin (IL-1beta and IL-6); increase the expression of apoptotic factor (Bcl-2); and decrease the expression of apoptotic factors (caspase-3 and Bax).	Triterpenes	42-55	lipopolysaccharide induced TNF factor	Gallus gallus	206-215
31222655-7	2019	The results showed that Ganoderma lucidum triterpenoids could reduce the content of Cd and MDA; increase the antioxidant enzyme activities (SOD and GSH-Px); decrease the expression of inflammatory factors (TNF-alpha) and interleukin (IL-1beta and IL-6); increase the expression of apoptotic factor (Bcl-2); and decrease the expression of apoptotic factors (caspase-3 and Bax).	Triterpenes	42-55	interleukin 1, beta	Gallus gallus	234-242
31222655-7	2019	The results showed that Ganoderma lucidum triterpenoids could reduce the content of Cd and MDA; increase the antioxidant enzyme activities (SOD and GSH-Px); decrease the expression of inflammatory factors (TNF-alpha) and interleukin (IL-1beta and IL-6); increase the expression of apoptotic factor (Bcl-2); and decrease the expression of apoptotic factors (caspase-3 and Bax).	Triterpenes	42-55	BCL2, apoptosis regulator	Gallus gallus	299-304
31222655-7	2019	The results showed that Ganoderma lucidum triterpenoids could reduce the content of Cd and MDA; increase the antioxidant enzyme activities (SOD and GSH-Px); decrease the expression of inflammatory factors (TNF-alpha) and interleukin (IL-1beta and IL-6); increase the expression of apoptotic factor (Bcl-2); and decrease the expression of apoptotic factors (caspase-3 and Bax).	Triterpenes	42-55	caspase 3	Gallus gallus	357-366
31002699-0	2019	Oral shea nut oil triterpene concentrate supplement ameliorates pain and histological assessment of articular cartilage deterioration in an ACLT injured rat knee osteoarthritis model.	Triterpenes	18-28	NUT midline carcinoma, family member 1	Rattus norvegicus	10-13
31081056-6	2019	It was also identified that a triterpene mixture extracted from the mushroom Poria cocos (PTE), purified triterpenes dehydropachymic acid, and polyporenic acid C (PPAC) downregulated the expression of CDC20 in PANC-1 cells dose-dependently.	Triterpenes	30-40	cell division cycle 20	Homo sapiens	201-206
31081056-6	2019	It was also identified that a triterpene mixture extracted from the mushroom Poria cocos (PTE), purified triterpenes dehydropachymic acid, and polyporenic acid C (PPAC) downregulated the expression of CDC20 in PANC-1 cells dose-dependently.	Triterpenes	105-116	cell division cycle 20	Homo sapiens	201-206
31081056-8	2019	Taken together, the present study is the first, to the best of our knowledge, to demonstrate that CDC20 serves an important role in cancer metastasis and that triterpenes from P. cocos inhibit the migration of pancreatic cancer cells associated with CDC20.	Triterpenes	159-170	cell division cycle 20	Homo sapiens	250-255
30965192-7	2019	The known triterpenes epigouanic acid and alphitolic acid were the most active compounds against B. subtilis, with IC50 of 12 and 22 muM, respectively.	Triterpenes	10-21	latexin	Homo sapiens	133-136
31105713-2	2019	The dipotassium glycyrrhizate (DPG), a salt of the glycoconjugated triterpene glycyrrhizin, has been shown to inhibit the High Mobility Group Box 1 (HMGB1) protein, an allarmin strongly implicated in the pathogenesis of most inflammatory and auto-immune disorders.	Triterpenes	67-77	high mobility group box 1	Homo sapiens	122-147
31105713-2	2019	The dipotassium glycyrrhizate (DPG), a salt of the glycoconjugated triterpene glycyrrhizin, has been shown to inhibit the High Mobility Group Box 1 (HMGB1) protein, an allarmin strongly implicated in the pathogenesis of most inflammatory and auto-immune disorders.	Triterpenes	67-77	high mobility group box 1	Homo sapiens	149-154
31308811-1	2019	Background: Ginsenoside Rb1, a triterpene saponin, is derived from the Panax ginseng root and has potent antiinflammatory activity.	Triterpenes	31-41	RB transcriptional corepressor 1	Mus musculus	24-27
31034197-0	2019	Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo.	Triterpenes	15-28	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	39-44
31034197-0	2019	Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo.	Triterpenes	15-28	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	78-83
31034197-4	2019	In this paper, 13 novel triterpenoids were created by synthetically modifying betulin, an abundant triterpenoid of the genus Betula L., and their TRPA1-modulating properties were examined.	Triterpenes	24-37	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	146-151
31034197-4	2019	In this paper, 13 novel triterpenoids were created by synthetically modifying betulin, an abundant triterpenoid of the genus Betula L., and their TRPA1-modulating properties were examined.	Triterpenes	24-36	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	146-151
31034197-5	2019	The Fluo 3-AM protocol was used in the initial screening, in which six of the 14 tested triterpenoids inhibited TRPA1 in a statistically significant manner.	Triterpenes	88-101	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	112-117
31034197-6	2019	In subsequent whole-cell patch clamp recordings, the two most effective compounds (pyrazine-fused triterpenoids 8 and 9) displayed a reversible and dose- and voltage-dependent effect to block the TRPA1 ion channel at submicromolar concentrations.	Triterpenes	98-111	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	196-201
31034197-8	2019	The results introduce betulin-derived pyrazine-fused triterpenoids as promising novel antagonists of TRPA1 that are potentially useful in treating diseases with a TRPA1-mediated adverse component.	Triterpenes	53-66	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	101-106
31034197-8	2019	The results introduce betulin-derived pyrazine-fused triterpenoids as promising novel antagonists of TRPA1 that are potentially useful in treating diseases with a TRPA1-mediated adverse component.	Triterpenes	53-66	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	163-168
31342717-7	2019	The screening results indicated that the anti-platelet aggregation effect of Xixian Tongshuan Preparation was correlated with the inhibition of P2 Y12,PAR1 and GPIIb/IIIa expressions with saffower yellower,hirudin and candidin and notoginseng triterpenes,folinic acid,respectively.	Triterpenes	243-254	purinergic receptor P2Y12	Homo sapiens	144-150
31002699-3	2019	Shea nut oil extract (SheaFlex75) contains a high triterpenoid concentration and has demonstrated anti-inflammatory and antiarthritic effects in both human and animal studies.	Triterpenes	50-62	NUT midline carcinoma family member 1	Homo sapiens	5-8
30153443-0	2018	A pentacyclic triterpene derivative possessing polyhydroxyl ring A suppresses growth of HeLa cells by reactive oxygen species-dependent NF-kappaB pathway.	Triterpenes	14-24	nuclear factor kappa B subunit 1	Homo sapiens	136-145
30833749-1	2019	Celastrol, a pentacyclic triterpene, is the most potent antiobesity agent that has been reported thus far1.	Triterpenes	25-35	fatty acyl CoA reductase 1	Mus musculus	102-106
30488503-8	2019	Usm contained diterpenes and triterpenes different of the other samples and Sil contained triterpenes and flavonoids.	Triterpenes	90-101	STIL centriolar assembly protein	Homo sapiens	76-79
30733795-2	2018	Generally, squalene synthase (SQS) is defined as an emerging and essential branch point enzyme far from the major pathway of isoprenoids biosynthetic and a latent adjusting point, which manages carbon flux into triterpenes biosynthesis and sterols.	Triterpenes	211-222	squalene synthase 1	Arabidopsis thaliana	11-28
30733795-2	2018	Generally, squalene synthase (SQS) is defined as an emerging and essential branch point enzyme far from the major pathway of isoprenoids biosynthetic and a latent adjusting point, which manages carbon flux into triterpenes biosynthesis and sterols.	Triterpenes	211-222	squalene synthase 1	Arabidopsis thaliana	30-33
31118567-1	2019	Background: Omaveloxolone is a synthetic oleanane triterpenoid that pharmacologically activates Nrf2, a master transcription factor that regulates genes with antioxidative, anti-inflammatory, and mitochondrial bioenergetic properties, and is being evaluated in patients with Friedreich"s ataxia.	Triterpenes	50-62	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
30862086-3	2019	The aim of this study was to identify hits with high binding affinity for the triterpene binding-allosteric sites of eNOS and CSE and to evaluate their vasodilator effect.	Triterpenes	78-88	cystathionine gamma-lyase	Rattus norvegicus	126-129
30803221-8	2019	Results: The fraction 2 (F2) of C. nutans showed thelowest IC50 value of 1.73 mug/ml against Hep-G2 cancer cells, and it is identified as triterpenes.	Triterpenes	138-149	DNL-type zinc finger	Homo sapiens	93-96
30584780-5	2019	Among the different chemical classes of natural NQO1 inhibitors are coumarins, flavonoids, and triterpenoids.	Triterpenes	95-108	NAD(P)H quinone dehydrogenase 1	Homo sapiens	48-52
30380745-6	2018	This triterpene positively regulated matrix metalloproteinase (MMP)-2 and inhibited the NF-kappaB expression in keratinocytes, suggesting an anti-inflammatory effect.	Triterpenes	5-15	matrix metallopeptidase 2	Homo sapiens	37-69
30148701-3	2018	Of the multifunctional triterpene ginsenosides, Rb1 enhances cutaneous wound healing process by increasing KC migration, but cellular mechanisms responsible for the Rb1-mediated increase in KC migration are largely unknown.	Triterpenes	23-33	RB transcriptional corepressor 1	Homo sapiens	48-51
29617770-8	2018	As a proof-of-concept, the triterpene friedelin was successfully produced in the same yeast strain by expressing its synthase with the truncated form of HMG1 linked by the 2A peptide of ERBV-1, with production titers comparable to monocistronic expression (via separate promoters).	Triterpenes	27-37	hydroxymethylglutaryl-CoA reductase (NADPH) HMG1	Saccharomyces cerevisiae S288C	153-157
30285704-9	2018	An increase in the levels of serum antioxidants such as catalase, superoxide dismutase, and reduced glutathione was noted in the rats treated with the triterpene, while their serum levels of interleukin-6 and malondialdehyde were reduced.	Triterpenes	151-161	interleukin 6	Rattus norvegicus	191-204
30209480-6	2018	The F601G/P602F double mutant also furnished a novel triterpene, named neogammacer-21(22)-en-3beta-ol, consisting of a 6,6,6,6,6-fused pentacyclic system, in which Me-29 at C-22 of the gammacerane skeleton migrated to C-21.	Triterpenes	53-63	TBL1X/Y related 1	Homo sapiens	218-222
30021372-5	2018	The present study was aimed to investigate the role of these triterpenes content in CA extract on the antioxidant, cholinesterase modulation and anti-amnesic properties.	Triterpenes	61-72	butyrylcholinesterase	Rattus norvegicus	115-129
29902502-12	2018	In conclusion, this study strongly demonstrates anti-oxidant and anti-ageing properties of H. scabra extracts containing triterpene glycosides, which, in the C. elegans model, may be mediated via the insulin/IGF-1 signaling (IIS)-DAF-16 pathway.	Triterpenes	121-131	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	230-236
29162643-8	2018	The structural comparison between hedragonic acid-bound FXR and oleanolic acid-bound GPBAR1 explained the molecular basis for the selectivity of oleanane-type triterpenes for FXR.	Triterpenes	159-170	nuclear receptor subfamily 1, group H, member 4	Mus musculus	56-59
30003730-0	2018	Lupeol triterpene exhibits potent antitumor effects in A427 human lung carcinoma cells via mitochondrial mediated apoptosis, ROS generation, loss of mitochondrial membrane potential and downregulation of m-TOR/PI3Ksol;AKT signalling pathway.	Triterpenes	7-17	RAR related orphan receptor C	Homo sapiens	206-209
31080345-11	2018	Plasma triterpene levels in patients treated with CAST mirrored neurotropic concentrations in vitro.	Triterpenes	7-17	calpastatin	Homo sapiens	50-54
29414121-15	2018	Copal, as well as the identified triterpenes, potently inhibited monoacylglycerol lipase (MAGL) activity in vitro (IC50 <= 811 ng/mL).	Triterpenes	33-44	monoglyceride lipase	Homo sapiens	65-88
29414121-15	2018	Copal, as well as the identified triterpenes, potently inhibited monoacylglycerol lipase (MAGL) activity in vitro (IC50 <= 811 ng/mL).	Triterpenes	33-44	monoglyceride lipase	Homo sapiens	90-94
29168472-0	2018	Characterization of naturally occurring pentacyclic triterpenes as novel inhibitors of deubiquitinating protease USP7 with anticancer activity in vitro.	Triterpenes	52-63	ubiquitin specific peptidase 7	Homo sapiens	113-117
29168472-2	2018	In the present study, we reported a series of natural pentacyclic triterpenes with USP7 inhibitory activity in vitro.	Triterpenes	66-77	ubiquitin specific peptidase 7	Homo sapiens	83-87
29168472-8	2018	In conclusion, we demonstrate for the first time that pentacyclic triterpenes represent a novel scaffold for developing USP7 inhibitors and that USP7 inhibition contributes to the anti-cancer effect of ursolic acid.	Triterpenes	66-77	ubiquitin specific peptidase 7	Homo sapiens	120-124
29162643-8	2018	The structural comparison between hedragonic acid-bound FXR and oleanolic acid-bound GPBAR1 explained the molecular basis for the selectivity of oleanane-type triterpenes for FXR.	Triterpenes	159-170	G protein-coupled bile acid receptor 1	Mus musculus	85-91
29162643-8	2018	The structural comparison between hedragonic acid-bound FXR and oleanolic acid-bound GPBAR1 explained the molecular basis for the selectivity of oleanane-type triterpenes for FXR.	Triterpenes	159-170	nuclear receptor subfamily 1, group H, member 4	Mus musculus	175-178
29162643-10	2018	In conclusion, our results provide novel structure templates for drug design based on natural triterpenes by targeting FXR and/or GPBAR1 with pharmaceutical values.	Triterpenes	94-105	nuclear receptor subfamily 1, group H, member 4	Mus musculus	119-122
29162643-10	2018	In conclusion, our results provide novel structure templates for drug design based on natural triterpenes by targeting FXR and/or GPBAR1 with pharmaceutical values.	Triterpenes	94-105	G protein-coupled bile acid receptor 1	Mus musculus	130-136
27650551-7	2017	Licorice extract, 3 triterpenes and 13 flavonoids exhibit evident anti-inflammatory properties mainly by decreasing TNF, MMPs, PGE2 and free radicals, which also explained its traditional applications in stimulating digestive system functions, eliminating phlegm, relieving coughing, nourishing qi and alleviating pain in TCM.	Triterpenes	20-31	tumor necrosis factor	Homo sapiens	116-119
28993280-2	2018	Our previous study revealed that the triterpene saponins in E.Phaseoloides possessed an antidiabetic effect in type 2 diabetic rats by activating AMP-activated protein kinase (AMPK).	Triterpenes	37-47	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	146-174
28993280-2	2018	Our previous study revealed that the triterpene saponins in E.Phaseoloides possessed an antidiabetic effect in type 2 diabetic rats by activating AMP-activated protein kinase (AMPK).	Triterpenes	37-47	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	176-180
29045755-0	2018	The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis.	Triterpenes	67-77	tripartite motif containing 69	Homo sapiens	4-20
29045755-6	2018	Here, we present the TriForC database (http://bioinformatics.psb.ugent.be/triforc/), encompassing a comprehensive catalogue of triterpene biosynthesis enzymes.	Triterpenes	127-137	tripartite motif containing 69	Homo sapiens	21-37
28583800-9	2017	We therefore propose further investigation of other compounds and their combinations such as the triterpene, alpha,beta-amyrin that exhibited greater binding affinity to CB1 than CB2 and was more potent than Delta9-THC and the N-alkylamides that exhibited CB2 selective affinity; the latter can be explored towards peripherally exclusive ECS modulation.	Triterpenes	97-107	cannabinoid receptor 1	Homo sapiens	170-173
28583800-9	2017	We therefore propose further investigation of other compounds and their combinations such as the triterpene, alpha,beta-amyrin that exhibited greater binding affinity to CB1 than CB2 and was more potent than Delta9-THC and the N-alkylamides that exhibited CB2 selective affinity; the latter can be explored towards peripherally exclusive ECS modulation.	Triterpenes	97-107	cannabinoid receptor 2	Homo sapiens	179-182
28583800-9	2017	We therefore propose further investigation of other compounds and their combinations such as the triterpene, alpha,beta-amyrin that exhibited greater binding affinity to CB1 than CB2 and was more potent than Delta9-THC and the N-alkylamides that exhibited CB2 selective affinity; the latter can be explored towards peripherally exclusive ECS modulation.	Triterpenes	97-107	cannabinoid receptor 2	Homo sapiens	256-259
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	Triterpenes	73-83	complement C2	Homo sapiens	48-59
29157826-2	2017	PURPOSE: In the present study, we aim to identify that ursolic acid (UA), a widely distributed pentacyclic triterpene, may act as an effective antagonist of PXR and its sister NR receptor, constitutive androstane receptor (CAR, NR1I3).	Triterpenes	107-117	nuclear receptor subfamily 1 group I member 3	Homo sapiens	189-221
28964635-0	2017	Pentacyclic triterpenes as alpha-glucosidase and alpha-amylase inhibitors: Structure-activity relationships and the synergism with acarbose.	Triterpenes	12-23	sucrase-isomaltase	Homo sapiens	27-44
28964635-1	2017	In this paper, the inhibition of alpha-amylase and alpha-glucosidase by nine pentacyclic triterpenes was determined.	Triterpenes	89-100	sucrase-isomaltase	Homo sapiens	51-68
28964635-5	2017	The combination of the tested triterpenes with acarbose mainly exhibited additive inhibition against alpha-glucosidase.	Triterpenes	30-41	sucrase-isomaltase	Homo sapiens	101-118
29024910-1	2017	Aiming to obtain new potent leishmanicidal and cytotoxic compounds from natural sources, the triterpene hederagenin was converted into several new 1,2,3-triazolyl derivatives tethered at C-23 and C-28.	Triterpenes	93-103	nucleolin	Homo sapiens	187-191
29170672-0	2017	Triterpene Structural Diversification by Plant Cytochrome P450 Enzymes.	Triterpenes	0-10	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	47-62
28881085-2	2017	We previously identified a bifunctional triterpene/sesquarterpene cyclase (TC) that constructs a tetracyclic scaffold from tetraprenyl-beta-curcumene (C35 ) but a bicyclic scaffold from squalene (C30 ) in the first reaction.	Triterpenes	40-50	migration and invasion enhancer 1	Homo sapiens	151-154
28640212-0	2017	Synthesis and In Vitro Anti-Influenza Virus Evaluation of Novel Sialic Acid (C-5 and C-9)-Pentacyclic Triterpene Derivatives.	Triterpenes	102-112	complement C5	Homo sapiens	77-88
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	Triterpenes	73-83	complement C4A (Rodgers blood group)	Homo sapiens	56-59
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	Triterpenes	73-83	complement C2	Homo sapiens	48-51
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	Triterpenes	227-237	complement C2	Homo sapiens	48-59
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	Triterpenes	227-237	complement C4A (Rodgers blood group)	Homo sapiens	56-59
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	Triterpenes	227-237	complement C2	Homo sapiens	48-51
28343085-0	2017	Guava fruit extract and its triterpene constituents have osteoanabolic effect: Stimulation of osteoblast differentiation by activation of mitochondrial respiration via the Wnt/beta-catenin signaling.	Triterpenes	28-38	catenin beta 1	Rattus norvegicus	176-188
28343085-0	2017	Guava fruit extract and its triterpene constituents have osteoanabolic effect: Stimulation of osteoblast differentiation by activation of mitochondrial respiration via the Wnt/beta-catenin signaling.	Triterpenes	28-38	Wnt family member 2	Rattus norvegicus	172-175
28343085-6	2017	Out of six abundantly present triterpenes in GE, ursolic acid (UA) and 2alpha-hydroxy ursolic acid (2alpha-UA) induced osteogenic differentiation in vitro as did GE by activating Wnt/beta-catenin pathway assessed by phosphorylation of GSK-3beta.	Triterpenes	30-41	Wnt family member 2	Rattus norvegicus	179-182
28343085-6	2017	Out of six abundantly present triterpenes in GE, ursolic acid (UA) and 2alpha-hydroxy ursolic acid (2alpha-UA) induced osteogenic differentiation in vitro as did GE by activating Wnt/beta-catenin pathway assessed by phosphorylation of GSK-3beta.	Triterpenes	30-41	catenin beta 1	Rattus norvegicus	183-195
28343085-6	2017	Out of six abundantly present triterpenes in GE, ursolic acid (UA) and 2alpha-hydroxy ursolic acid (2alpha-UA) induced osteogenic differentiation in vitro as did GE by activating Wnt/beta-catenin pathway assessed by phosphorylation of GSK-3beta.	Triterpenes	30-41	glycogen synthase kinase 3 beta	Rattus norvegicus	235-244
28445411-1	2017	The pentacyclic triterpene oleanolic acid (OA, 1) with known farnesoid X receptor (FXR) modulatory activity was modified at its C-3 position to find new FXR-interacting agents.	Triterpenes	16-26	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	71-81
28532507-8	2017	The overexpression of A. thaliana ACL and AACT and HMGR in T. brevicorniculatum latex resulted in the accumulation of all three enzymes, increased the corresponding enzymatic activities and ultimately increased sterol levels by ~5-fold and pentacyclic triterpene and cis-1,4-isoprene levels by ~2-fold.	Triterpenes	252-262	acetone-cyanohydrin lyase	Arabidopsis thaliana	34-37
28445411-1	2017	The pentacyclic triterpene oleanolic acid (OA, 1) with known farnesoid X receptor (FXR) modulatory activity was modified at its C-3 position to find new FXR-interacting agents.	Triterpenes	16-26	nuclear receptor subfamily 1 group H member 4	Homo sapiens	83-86
28445411-1	2017	The pentacyclic triterpene oleanolic acid (OA, 1) with known farnesoid X receptor (FXR) modulatory activity was modified at its C-3 position to find new FXR-interacting agents.	Triterpenes	16-26	nuclear receptor subfamily 1 group H member 4	Homo sapiens	153-156
28758107-5	2017	Among the approximately 400 compounds produced by Ganoderma spp., triterpenes, peptidoglycans and polysaccharides are the major physiologically-active constituents.	Triterpenes	66-77	histocompatibility minor 13	Homo sapiens	60-63
28487767-0	2017	Inducement of apoptosis by cucurbitacin E, a tetracyclic triterpenes, through death receptor 5 in human cervical cancer cell lines.	Triterpenes	57-68	TNF receptor superfamily member 10b	Homo sapiens	78-94
28388439-3	2017	Here, we report that celastrol, a potent anti-inflammatory pentacyclic triterpene, binds Nur77 to inhibit inflammation and induce autophagy in a Nur77-dependent manner.	Triterpenes	71-81	nuclear receptor subfamily 4 group A member 1	Homo sapiens	89-94
27285057-2	2016	While the biosynthesis of cyclic monoterpenes (C10) and sesquiterpenes (C15) most often involves enzymes with alpha or alphabeta domain architecture, the biosynthesis of cyclic diterpenes (C20), sesterterpenes (C25), and triterpenes (C30) can involve enzymes with alpha, alphaalpha, betagamma, or alphabetagamma domain architecture.	Triterpenes	221-232	homeobox C10	Homo sapiens	47-50
28216107-4	2017	Here, we show that the disruption of the phosphatidic acid phosphatase-encoding PAH1 through CRISPR/Cas9 results in a dramatic expansion of the endoplasmic reticulum (ER), which stimulated the production of recombinant triterpene biosynthesis enzymes and ultimately boosted triterpenoid and triterpene saponin accumulation.	Triterpenes	219-229	phosphatidate phosphatase PAH1	Saccharomyces cerevisiae S288C	80-84
28216107-4	2017	Here, we show that the disruption of the phosphatidic acid phosphatase-encoding PAH1 through CRISPR/Cas9 results in a dramatic expansion of the endoplasmic reticulum (ER), which stimulated the production of recombinant triterpene biosynthesis enzymes and ultimately boosted triterpenoid and triterpene saponin accumulation.	Triterpenes	291-301	phosphatidate phosphatase PAH1	Saccharomyces cerevisiae S288C	80-84
28161992-9	2017	The chemical analysis reveals ACE is full of triterpenes, the most abundant of which is Antcin K, followed by sulphurenic acid, eburicoic acid, antcin C, dehydrosulphurenic acid, antcin B, and propanoic acid.	Triterpenes	45-56	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	30-33
28845774-4	2017	A reverse-phase high-performance liquid chromatography (HPLC) method was used to quantify 2 of the most bioactive triterpenes, ganoderic acid A (GAA) and ganoderic acid B (GAB), among the cultivated Ganoderma spp.	Triterpenes	114-125	alpha glucosidase	Homo sapiens	145-148
28845774-4	2017	A reverse-phase high-performance liquid chromatography (HPLC) method was used to quantify 2 of the most bioactive triterpenes, ganoderic acid A (GAA) and ganoderic acid B (GAB), among the cultivated Ganoderma spp.	Triterpenes	114-125	alpha-1-B glycoprotein	Homo sapiens	172-175
28010928-3	2017	Total triterpenes induced apoptosis in MCF-7 cells by down-regulating the levels of cyclin D1, Bcl-2, Bcl-xL and also by up-regulating the levels of Bax and caspase-9.	Triterpenes	6-17	cyclin D1	Homo sapiens	84-93
28010928-3	2017	Total triterpenes induced apoptosis in MCF-7 cells by down-regulating the levels of cyclin D1, Bcl-2, Bcl-xL and also by up-regulating the levels of Bax and caspase-9.	Triterpenes	6-17	BCL2 apoptosis regulator	Homo sapiens	95-100
28010928-3	2017	Total triterpenes induced apoptosis in MCF-7 cells by down-regulating the levels of cyclin D1, Bcl-2, Bcl-xL and also by up-regulating the levels of Bax and caspase-9.	Triterpenes	6-17	BCL2 like 1	Homo sapiens	102-108
28010928-3	2017	Total triterpenes induced apoptosis in MCF-7 cells by down-regulating the levels of cyclin D1, Bcl-2, Bcl-xL and also by up-regulating the levels of Bax and caspase-9.	Triterpenes	6-17	BCL2 associated X, apoptosis regulator	Homo sapiens	149-152
28010928-3	2017	Total triterpenes induced apoptosis in MCF-7 cells by down-regulating the levels of cyclin D1, Bcl-2, Bcl-xL and also by up-regulating the levels of Bax and caspase-9.	Triterpenes	6-17	caspase 9	Homo sapiens	157-166
27285057-2	2016	While the biosynthesis of cyclic monoterpenes (C10) and sesquiterpenes (C15) most often involves enzymes with alpha or alphabeta domain architecture, the biosynthesis of cyclic diterpenes (C20), sesterterpenes (C25), and triterpenes (C30) can involve enzymes with alpha, alphaalpha, betagamma, or alphabetagamma domain architecture.	Triterpenes	221-232	placenta associated 8	Homo sapiens	72-75
28337107-3	2016	Particularly, lupane-type triterpenes have shown great ability to modulate multiple cancer-related signaling pathways and processes, including NF-kappaB, Wnt/beta-catenin, PI3K/Akt, apoptosis, and many other routes related to proliferation or cell death, which are uncontrolled in malignant tumors.	Triterpenes	26-37	catenin beta 1	Homo sapiens	158-170
28337107-3	2016	Particularly, lupane-type triterpenes have shown great ability to modulate multiple cancer-related signaling pathways and processes, including NF-kappaB, Wnt/beta-catenin, PI3K/Akt, apoptosis, and many other routes related to proliferation or cell death, which are uncontrolled in malignant tumors.	Triterpenes	26-37	AKT serine/threonine kinase 1	Homo sapiens	177-180
25874923-0	2015	Esters of the marine-derived triterpene sipholenol A reverse P-GP-mediated drug resistance.	Triterpenes	29-39	phosphoglycolate phosphatase	Homo sapiens	61-65
27496961-0	2016	Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.	Triterpenes	13-23	TNF superfamily member 10	Homo sapiens	34-39
27496965-0	2016	Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors.	Triterpenes	28-38	TNF superfamily member 10	Homo sapiens	52-57
26632982-6	2016	Three structural types of NF-kappaB inhibitors (caffeic acid derivatives, flavonoids and Pentacyclic triterpenes) were characterized.	Triterpenes	101-112	nuclear factor kappa B subunit 1	Homo sapiens	26-35
27288915-3	2016	PURPOSE: This study aims to investigate the anti-cancer potential of alisol B 23-acetate (AB23), a protostane-type triterpene isolated from the Alismatis Rhizoma, in the parental and paclitaxel-resistant ovarian cancer cells.	Triterpenes	115-125	NBPF member 1	Homo sapiens	69-88
27288915-3	2016	PURPOSE: This study aims to investigate the anti-cancer potential of alisol B 23-acetate (AB23), a protostane-type triterpene isolated from the Alismatis Rhizoma, in the parental and paclitaxel-resistant ovarian cancer cells.	Triterpenes	115-125	NBPF member 1	Homo sapiens	90-94
28852714-0	2016	THE EFFECTS OF Syzygium aromaticum-DERIVED TRITERPENES ON GASTROINTESTINAL GHRELIN EXPRESSION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.	Triterpenes	43-54	ghrelin and obestatin prepropeptide	Rattus norvegicus	75-82
28852714-10	2016	This was further complemented by significant reductions in the gastrointestinal expression of ghrelin suggesting that the anti-diabetic properties of these triterpenes are mediated, in part, through the reduction of food intake and the modulation of ghrelin expression.	Triterpenes	156-167	ghrelin and obestatin prepropeptide	Rattus norvegicus	94-101
28852714-10	2016	This was further complemented by significant reductions in the gastrointestinal expression of ghrelin suggesting that the anti-diabetic properties of these triterpenes are mediated, in part, through the reduction of food intake and the modulation of ghrelin expression.	Triterpenes	156-167	ghrelin and obestatin prepropeptide	Rattus norvegicus	250-257
26887328-6	2016	These activities (melanin biosynthesis stimulatory and protective effect against H2 O2 of CS2 and hyaluronic acid productive activities of these triterpene derivatives) have been reported for the first time.	Triterpenes	145-155	calsyntenin 2	Mus musculus	90-93
26801524-4	2016	In this study, Arabidopsis thaliana CYP716A1 and CYP716A2 were characterized by heterologously expressing them in simple triterpene-producing yeast strains.	Triterpenes	121-131	cytochrome P450, family 716, subfamily A, polypeptide 1	Arabidopsis thaliana	36-44
26801524-4	2016	In this study, Arabidopsis thaliana CYP716A1 and CYP716A2 were characterized by heterologously expressing them in simple triterpene-producing yeast strains.	Triterpenes	121-131	cytochrome P450, family 716, subfamily A, polypeptide 2	Arabidopsis thaliana	49-57
26833423-0	2016	Novel microspheres based on triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae) for the improvement of gemcitabine release.	Triterpenes	28-38	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	107-110
26777089-4	2016	Two natural well known HNE inhibitors from the triterpene family, ursolic acid and oleanolic acid, were tested to validate the developed assay.	Triterpenes	47-57	elastase, neutrophil expressed	Homo sapiens	23-26
26343139-6	2016	These triterpenes significantly inhibited the growth of the HeLa, KB, MCF-7 and Hep-G2 cancer cell lines at micromolar concentrations.	Triterpenes	6-17	DNL-type zinc finger	Homo sapiens	80-83
28003581-0	2016	Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma cells.	Triterpenes	0-11	appetite-regulating hormone	Capra hircus	34-41
28003581-0	2016	Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma cells.	Triterpenes	0-11	appetite-regulating hormone	Capra hircus	56-63
28003581-5	2016	Since such triterpenes, like fatty acids, have a carboxyl group, we speculated that they can suppress octanoylated ghrelin production.	Triterpenes	11-22	appetite-regulating hormone	Capra hircus	115-122
28003581-6	2016	To test this hypothesis, we investigated the effect of triterpenes on octanoylated ghrelin production.	Triterpenes	55-66	appetite-regulating hormone	Capra hircus	83-90
28003581-9	2016	These results suggest that triterpenes may have the potential as obesity-preventing agents with suppressive effect on octanoylated ghrelin production.	Triterpenes	27-38	appetite-regulating hormone	Capra hircus	131-138
26342572-1	2015	Triterpenes and sterols are good candidates for the development of anti-inflammatory drugs and use in chemoprevention or chemotherapy of cancer via the interaction with therapeutic targets related to inflammation, such as COX-1 and -2; LOX-5; MPO, PLA2 and i-NOS.	Triterpenes	0-11	phospholipase A2 group IB	Homo sapiens	248-252
26342572-1	2015	Triterpenes and sterols are good candidates for the development of anti-inflammatory drugs and use in chemoprevention or chemotherapy of cancer via the interaction with therapeutic targets related to inflammation, such as COX-1 and -2; LOX-5; MPO, PLA2 and i-NOS.	Triterpenes	0-11	nitric oxide synthase 2	Homo sapiens	257-262
25993687-6	2015	METHODS: Triterpene ganoderic acid C1 (GAC1) was isolated from G. lucidum.	Triterpenes	9-19	ankyrin repeat domain 12	Homo sapiens	39-43
27592454-0	2016	The triterpene echinocystic acid and its 3-O-glucoside derivative are revealed as potent and selective glucocorticoid receptor agonists.	Triterpenes	4-14	nuclear receptor subfamily 3 group C member 1	Homo sapiens	103-126
27344437-5	2016	Triterpenes are immunomodulatory targeting nuclear factor kappa B, toll-like receptors, signal transducer and activator of transcription 3, and PI3K/Akt/mTOR.	Triterpenes	0-11	signal transducer and activator of transcription 3	Homo sapiens	88-138
27344437-5	2016	Triterpenes are immunomodulatory targeting nuclear factor kappa B, toll-like receptors, signal transducer and activator of transcription 3, and PI3K/Akt/mTOR.	Triterpenes	0-11	AKT serine/threonine kinase 1	Homo sapiens	149-152
27344437-5	2016	Triterpenes are immunomodulatory targeting nuclear factor kappa B, toll-like receptors, signal transducer and activator of transcription 3, and PI3K/Akt/mTOR.	Triterpenes	0-11	mechanistic target of rapamycin kinase	Homo sapiens	153-157
27583436-0	2016	Shea Nut Oil Triterpene Concentrate Attenuates Knee Osteoarthritis Development in Rats: Evidence from Knee Joint Histology.	Triterpenes	13-23	NUT midline carcinoma, family member 1	Rattus norvegicus	5-8
27583436-1	2016	BACKGROUND: Shea nut oil triterpene concentrate is considered to have anti-inflammatory and antioxidant properties.	Triterpenes	25-35	NUT midline carcinoma, family member 1	Rattus norvegicus	17-20
27583436-3	2016	This study aimed to investigate the effect of attenuating osteoarthritis (OA)-induced pain and joint destruction in rats by administering shea nut oil triterpene concentrate (SheaFlex75, which is more than 50% triterpenes).	Triterpenes	151-161	NUT midline carcinoma, family member 1	Rattus norvegicus	143-146
27583436-3	2016	This study aimed to investigate the effect of attenuating osteoarthritis (OA)-induced pain and joint destruction in rats by administering shea nut oil triterpene concentrate (SheaFlex75, which is more than 50% triterpenes).	Triterpenes	210-221	NUT midline carcinoma, family member 1	Rattus norvegicus	143-146
27177748-1	2016	Ginsenoside Rh2, a triterpene saponin extracted from Panax ginseng, exhibits pharmacological activity against multiple cancers.	Triterpenes	19-29	Rh associated glycoprotein	Homo sapiens	12-15
26751347-5	2016	Subtle difference of functional groups at C-2 position in hopane-type triterpene resulted in enormous bioactivity difference, compound 1 was neurotrophic but 2 was cytotoxic.	Triterpenes	70-80	complement C2	Rattus norvegicus	42-45
26883702-0	2016	Successful Therapy of Murine Visceral Leishmaniasis with Astrakurkurone, a Triterpene Isolated from the Mushroom Astraeus hygrometricus, Involves the Induction of Protective Cell-Mediated Immunity and TLR9.	Triterpenes	75-85	toll-like receptor 9	Mus musculus	201-205
27070561-5	2016	Among these Delta(11,13) oleanane-type triterpenes, compound 3 showed significant NO inhibitory activity in BV-2 cells, reducing the LPS-induced expression of COX-2 and pro-inflammatory cytokines such as TNF-alpha and IL-6.	Triterpenes	39-50	cytochrome c oxidase II, mitochondrial	Mus musculus	159-164
27070561-5	2016	Among these Delta(11,13) oleanane-type triterpenes, compound 3 showed significant NO inhibitory activity in BV-2 cells, reducing the LPS-induced expression of COX-2 and pro-inflammatory cytokines such as TNF-alpha and IL-6.	Triterpenes	39-50	tumor necrosis factor	Mus musculus	204-213
26865097-0	2016	Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B.	Triterpenes	68-79	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	83-114
26865097-5	2016	Using computational studies including molecular docking, molecular dynamics simulations, and binding free energy calculations, we found that lupane triterpenes selectively inhibited PTP1B by targeting its more hydrophobic and less conserved allosteric site.	Triterpenes	148-159	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	182-187
26865097-8	2016	Our study indicates that lupane triterpenes are selective PTP1B allosteric inhibitors with significant potential for treating those diseases with elevated PTP1B activity.	Triterpenes	32-43	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	58-63
26865097-8	2016	Our study indicates that lupane triterpenes are selective PTP1B allosteric inhibitors with significant potential for treating those diseases with elevated PTP1B activity.	Triterpenes	32-43	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	155-160
26584875-10	2016	The hyperlipidemia mice treated with the triterpene fraction showed a significant decrease in serum TC, LDL-C and AI after continuous consumption of HFD for 4 weeks.	Triterpenes	41-51	component of oligomeric golgi complex 2	Mus musculus	104-109
26342572-1	2015	Triterpenes and sterols are good candidates for the development of anti-inflammatory drugs and use in chemoprevention or chemotherapy of cancer via the interaction with therapeutic targets related to inflammation, such as COX-1 and -2; LOX-5; MPO, PLA2 and i-NOS.	Triterpenes	0-11	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	222-234
26342572-1	2015	Triterpenes and sterols are good candidates for the development of anti-inflammatory drugs and use in chemoprevention or chemotherapy of cancer via the interaction with therapeutic targets related to inflammation, such as COX-1 and -2; LOX-5; MPO, PLA2 and i-NOS.	Triterpenes	0-11	arachidonate 5-lipoxygenase	Homo sapiens	236-241
26342572-1	2015	Triterpenes and sterols are good candidates for the development of anti-inflammatory drugs and use in chemoprevention or chemotherapy of cancer via the interaction with therapeutic targets related to inflammation, such as COX-1 and -2; LOX-5; MPO, PLA2 and i-NOS.	Triterpenes	0-11	myeloperoxidase	Homo sapiens	243-246
26260291-4	2015	The impact of these triterpenes upon the activity and protein expression of enzymes involved in polyol pathway including aldose reductase and sorbitol dehydrogenase has been examined, and positive results are reported.	Triterpenes	20-31	aldo-keto reductase family 1 member B	Homo sapiens	121-137
26260291-4	2015	The impact of these triterpenes upon the activity and protein expression of enzymes involved in polyol pathway including aldose reductase and sorbitol dehydrogenase has been examined, and positive results are reported.	Triterpenes	20-31	sorbitol dehydrogenase	Homo sapiens	142-164
25874923-1	2015	Our previous studies showed that several sipholane triterpenes, sipholenol A, sipholenone E, sipholenol L and siphonellinol D, have potent reversal effect for multidrug resistance (MDR) in cancer cells that overexpressed P-glycoprotein (P-gp/ABCB1).	Triterpenes	51-62	ATP binding cassette subfamily B member 1	Homo sapiens	221-235
25874923-1	2015	Our previous studies showed that several sipholane triterpenes, sipholenol A, sipholenone E, sipholenol L and siphonellinol D, have potent reversal effect for multidrug resistance (MDR) in cancer cells that overexpressed P-glycoprotein (P-gp/ABCB1).	Triterpenes	51-62	phosphoglycolate phosphatase	Homo sapiens	237-241
25874923-1	2015	Our previous studies showed that several sipholane triterpenes, sipholenol A, sipholenone E, sipholenol L and siphonellinol D, have potent reversal effect for multidrug resistance (MDR) in cancer cells that overexpressed P-glycoprotein (P-gp/ABCB1).	Triterpenes	51-62	ATP binding cassette subfamily B member 1	Homo sapiens	242-247
25575098-0	2015	Identification in Rat Plasma and Urine by Linear Trap Quadrupole-Orbitrap Mass Spectrometry of the Metabolites of Maslinic Acid, a Triterpene from Olives.	Triterpenes	131-141	tudor domain containing 7	Rattus norvegicus	49-53
25453801-0	2014	Cycloartane-type triterpenes from Euphorbia fischeriana stimulate  human CYP3A4 promoter activity.	Triterpenes	17-28	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	73-79
25859175-2	2015	Triterpenes with unsubstituted C-3 hydroxyl group can be easily transformed into appropriate ketones and then into oximes.	Triterpenes	0-11	complement C3	Homo sapiens	31-34
25859175-5	2015	There are also known triterpenes with two carbonyl groups, e.g. at C-3 and C-11 positions, which differ in reactivity: among them only C-3 group can be transformed into oxime.	Triterpenes	21-32	complement C3	Homo sapiens	67-70
25859175-5	2015	There are also known triterpenes with two carbonyl groups, e.g. at C-3 and C-11 positions, which differ in reactivity: among them only C-3 group can be transformed into oxime.	Triterpenes	21-32	RNA polymerase III subunit K	Homo sapiens	75-79
25859175-5	2015	There are also known triterpenes with two carbonyl groups, e.g. at C-3 and C-11 positions, which differ in reactivity: among them only C-3 group can be transformed into oxime.	Triterpenes	21-32	complement C3	Homo sapiens	135-138
25156906-3	2014	We found that either the triterpenes or peptide part alone showed weak activity against HIV-1 Env-mediated cell-cell fusion, while the hybrids generated a strong cooperative effect.	Triterpenes	25-36	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	94-97
25264584-2	2014	Pentacyclic acid triterpenes such as oleanolic acid (OA) have proved to be excellent PTP-1B inhibitors, thus, the purpose of current work was to generate a series of derivatives that improve the pharmacological effect of OA.	Triterpenes	17-28	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	85-91
25372486-2	2014	Here we studied the modulation of intermediate-conductance Ca(2+)/calmodulin-regulated K(+) channels (K(Ca)3.1) by EETs, 20-HETE, omega3, and pentacyclic triterpenes and the structural requirements of these fatty acids to exert channel blockade.	Triterpenes	154-165	calmodulin 1	Homo sapiens	66-76
25372486-2	2014	Here we studied the modulation of intermediate-conductance Ca(2+)/calmodulin-regulated K(+) channels (K(Ca)3.1) by EETs, 20-HETE, omega3, and pentacyclic triterpenes and the structural requirements of these fatty acids to exert channel blockade.	Triterpenes	154-165	potassium calcium-activated channel subfamily N member 4	Homo sapiens	102-110
24915879-0	2014	Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists.	Triterpenes	0-11	androgen receptor	Homo sapiens	42-59
24915879-0	2014	Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists.	Triterpenes	0-11	progesterone receptor	Homo sapiens	70-91
24915879-0	2014	Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists.	Triterpenes	0-11	nuclear receptor subfamily 3 group C member 1	Homo sapiens	109-132
24915879-3	2014	In this study, two triterpenes, alisol M 23-acetate and alisol A 23-acetate from Alisma orientalis were determined whether they may act as androgen receptor (AR), progesterone receptor (PR), or glucocorticoid receptor (GR) modulators.	Triterpenes	19-30	androgen receptor	Homo sapiens	139-156
24915879-3	2014	In this study, two triterpenes, alisol M 23-acetate and alisol A 23-acetate from Alisma orientalis were determined whether they may act as androgen receptor (AR), progesterone receptor (PR), or glucocorticoid receptor (GR) modulators.	Triterpenes	19-30	androgen receptor	Homo sapiens	158-160
24915879-3	2014	In this study, two triterpenes, alisol M 23-acetate and alisol A 23-acetate from Alisma orientalis were determined whether they may act as androgen receptor (AR), progesterone receptor (PR), or glucocorticoid receptor (GR) modulators.	Triterpenes	19-30	progesterone receptor	Homo sapiens	163-184
24915879-3	2014	In this study, two triterpenes, alisol M 23-acetate and alisol A 23-acetate from Alisma orientalis were determined whether they may act as androgen receptor (AR), progesterone receptor (PR), or glucocorticoid receptor (GR) modulators.	Triterpenes	19-30	progesterone receptor	Homo sapiens	186-188
24333132-0	2014	EGFR inhibition by pentacyclic triterpenes exhibit cell cycle and growth arrest in breast cancer cells.	Triterpenes	31-42	epidermal growth factor receptor	Homo sapiens	0-4
24815008-0	2014	Oleanane triterpenes as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Camellia japonica.	Triterpenes	9-20	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	57-62
24815008-3	2014	As part of our continuous research on PTP1B inhibitors from medicinal plants, four oleanane-type triterpenes were isolated from an EtOAc-soluble extract of fruit peels of Camellia japonica (Theaceae), together with 6 previously known compounds of this class.	Triterpenes	97-108	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	38-43
24879289-6	2014	METHODOLOGY/PRINCIPAL FINDINGS: Here we report the unexpected discovery that certain triterpene-based structures inhibit human ABHD12 hydrolase activity in a reversible manner, the best compounds showing submicromolar potency.	Triterpenes	85-95	abhydrolase domain containing 12, lysophospholipase	Homo sapiens	127-133
24879289-8	2014	A pentacyclic triterpene backbone with carboxyl group at position 17, small hydrophobic substituent at the position 4, hydrogen bond donor or acceptor at position 3 accompanied with four axial methyl substituents was found crucial for ABHD12 inhibitor activity.	Triterpenes	14-24	abhydrolase domain containing 12, lysophospholipase	Homo sapiens	235-241
24879289-10	2014	CONCLUSIONS/SIGNIFICANCE: We have identified reversibly-acting triterpene-based inhibitors that show remarkable selectivity for ABHD12 over other metabolic serine hydrolases.	Triterpenes	63-73	abhydrolase domain containing 12, lysophospholipase	Homo sapiens	128-134
24393047-3	2014	However, pre-treatments of three triterpenes reserved glutathione, maintained activity and expression of GPX, GR, and catalase, as well as lowered ROS, GSSG, and inflammatory cytokines generation.	Triterpenes	33-44	glutathione-disulfide reductase	Rattus norvegicus	110-112
24393047-5	2014	Pre-treatments of three triterpenes retained Na(+)-K(+)-ATPase activity, declined NF-kappaB and caspase-3 activities, reserved Bcl-2 expression, as well as suppressed protein expression of NF-kappaB, p-p38, Bax, and cleaved caspase-3.	Triterpenes	24-35	caspase 3	Rattus norvegicus	96-105
24393047-5	2014	Pre-treatments of three triterpenes retained Na(+)-K(+)-ATPase activity, declined NF-kappaB and caspase-3 activities, reserved Bcl-2 expression, as well as suppressed protein expression of NF-kappaB, p-p38, Bax, and cleaved caspase-3.	Triterpenes	24-35	BCL2, apoptosis regulator	Rattus norvegicus	127-132
24393047-5	2014	Pre-treatments of three triterpenes retained Na(+)-K(+)-ATPase activity, declined NF-kappaB and caspase-3 activities, reserved Bcl-2 expression, as well as suppressed protein expression of NF-kappaB, p-p38, Bax, and cleaved caspase-3.	Triterpenes	24-35	BCL2 associated X, apoptosis regulator	Rattus norvegicus	207-210
24393047-5	2014	Pre-treatments of three triterpenes retained Na(+)-K(+)-ATPase activity, declined NF-kappaB and caspase-3 activities, reserved Bcl-2 expression, as well as suppressed protein expression of NF-kappaB, p-p38, Bax, and cleaved caspase-3.	Triterpenes	24-35	caspase 3	Rattus norvegicus	224-233
24333132-8	2014	Interestingly, pentacyclic triterpenes limit EGF mediated breast cancer proliferation through sustained inhibition of EGFR and its downstream effectors STAT3 and cyclin D1 in breast cancer lines.	Triterpenes	27-38	epidermal growth factor receptor	Homo sapiens	118-122
24333132-8	2014	Interestingly, pentacyclic triterpenes limit EGF mediated breast cancer proliferation through sustained inhibition of EGFR and its downstream effectors STAT3 and cyclin D1 in breast cancer lines.	Triterpenes	27-38	signal transducer and activator of transcription 3	Homo sapiens	152-157
24333132-8	2014	Interestingly, pentacyclic triterpenes limit EGF mediated breast cancer proliferation through sustained inhibition of EGFR and its downstream effectors STAT3 and cyclin D1 in breast cancer lines.	Triterpenes	27-38	cyclin D1	Homo sapiens	162-171
24333132-9	2014	We also show pentacyclic triterpenes to bind at the ATP binding pocket of tyrosine kinase domain of EGFR leading to the hypothesis that pentacyclic triterpenes could be a novel class of EGFR inhibitors.	Triterpenes	25-36	epidermal growth factor receptor	Homo sapiens	100-104
24333132-9	2014	We also show pentacyclic triterpenes to bind at the ATP binding pocket of tyrosine kinase domain of EGFR leading to the hypothesis that pentacyclic triterpenes could be a novel class of EGFR inhibitors.	Triterpenes	25-36	epidermal growth factor receptor	Homo sapiens	186-190
24333132-9	2014	We also show pentacyclic triterpenes to bind at the ATP binding pocket of tyrosine kinase domain of EGFR leading to the hypothesis that pentacyclic triterpenes could be a novel class of EGFR inhibitors.	Triterpenes	148-159	epidermal growth factor receptor	Homo sapiens	100-104
24333132-9	2014	We also show pentacyclic triterpenes to bind at the ATP binding pocket of tyrosine kinase domain of EGFR leading to the hypothesis that pentacyclic triterpenes could be a novel class of EGFR inhibitors.	Triterpenes	148-159	epidermal growth factor receptor	Homo sapiens	186-190
24333132-10	2014	In conclusion, pentacyclic triterpenes inhibit EGFR activation through binding with tyrosine kinase domain thereby suppressing breast cancer proliferation.	Triterpenes	27-38	epidermal growth factor receptor	Homo sapiens	47-51
24844815-6	2014	Over-expression of ACL in Arabidopsis was associated with a 30% increase in wax on stems, while over-expression of a chimeric homomeric ACL in the laticifer of roots of dandelion led to a four- and two-fold increase in rubber and triterpene content, respectively.	Triterpenes	230-240	acetone-cyanohydrin lyase	Arabidopsis thaliana	19-22
24844815-6	2014	Over-expression of ACL in Arabidopsis was associated with a 30% increase in wax on stems, while over-expression of a chimeric homomeric ACL in the laticifer of roots of dandelion led to a four- and two-fold increase in rubber and triterpene content, respectively.	Triterpenes	230-240	acetone-cyanohydrin lyase	Arabidopsis thaliana	136-139
24333132-4	2014	Growth inhibition, new DNA synthesis, colony formation assays and Western blot analysis were performed to assess the EGFR inhibitory effect of triterpenes.	Triterpenes	143-154	epidermal growth factor receptor	Homo sapiens	117-121
24333132-5	2014	Molecular docking was performed to study the interaction between EGFR and triterpenes.	Triterpenes	74-85	epidermal growth factor receptor	Homo sapiens	65-69
24713615-8	2014	As Hsp90 participates in the targeting of misfolded proteins to the proteasome pathway, its down-modulation in response to celastrol may partly account for the mechanism of improved homeostasis of L444P GCase mediated by this triterpene.	Triterpenes	226-236	heat shock protein 90 alpha family class A member 1	Homo sapiens	3-8
24980865-0	2014	Stimulating effect of a new triterpene derived from Anoectochilus elwesii on glucose uptake in insulin-resistant human HepG2 cells.	Triterpenes	28-38	insulin	Homo sapiens	95-102
24260073-0	2013	Asiatic acid, a triterpene, inhibits cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells.	Triterpenes	16-26	protein tyrosine kinase 2	Homo sapiens	93-114
24376583-0	2013	Inhibition of human neutrophil elastase by pentacyclic triterpenes.	Triterpenes	55-66	elastase, neutrophil expressed	Homo sapiens	20-39
24376583-4	2013	METHODS AND RESULTS: An in vitro HNE inhibition assay was employed to screen a series of triterpenes.	Triterpenes	89-100	elastase, neutrophil expressed	Homo sapiens	33-36
24376583-5	2013	Six pentacyclic triterpenes, but not tetracyclic triterpenes, significantly inhibited HNE.	Triterpenes	16-27	elastase, neutrophil expressed	Homo sapiens	86-89
24376583-8	2013	The results of nuclear magnetic resonance and HNE inhibition kinetic analysis showed that the pentacyclic triterpenes competitively and reversibly inhibited HNE.	Triterpenes	106-117	elastase, neutrophil expressed	Homo sapiens	46-49
24376583-8	2013	The results of nuclear magnetic resonance and HNE inhibition kinetic analysis showed that the pentacyclic triterpenes competitively and reversibly inhibited HNE.	Triterpenes	106-117	elastase, neutrophil expressed	Homo sapiens	157-160
24376583-10	2013	CONCLUSION: Our results provide insights into the effects of pentacyclic triterpenes on lung inflammatory actions through reversible inhibition of HNE activity.	Triterpenes	73-84	elastase, neutrophil expressed	Homo sapiens	147-150
24225772-15	2013	Moreover, Annexin-V/PI double staining and flow cytometry showed that the combination of alkaloids and triterpenes (1, 2 and 3 mg raw material/kg) could induce apoptosis and cause S cell cycle arrest in A549 cells.	Triterpenes	103-114	annexin A5	Mus musculus	10-19
24303085-4	2013	Furthermore, lupeol, a pentacyclic triterpene, was identified in the CH2Cl2 fraction of CIE to attenuate LMP1-induced NF-kappaB activation and LCL viability.	Triterpenes	35-45	PDZ and LIM domain 7	Homo sapiens	105-109
23909862-7	2013	A novel triterpene structure, dihydrolupeol, was produced by AMY2.	Triterpenes	8-18	AMY2	Lotus japonicus	61-65
23836602-4	2013	METHODS AND RESULTS: Using human CRC cells that exhibit differential expression of Wnt/beta-catenin signaling, we demonstrate that treatment of CRC cells with dietary triterpene lupeol results in a dose-dependent (i) decrease in cell viability, (ii) induction of apoptosis, (iii) decrease in colonogenic potential, (iv) decrease in beta-catenin transcriptional activity, and (v) decrease in the expression of Wnt target genes.	Triterpenes	167-177	catenin beta 1	Homo sapiens	87-99
23836602-4	2013	METHODS AND RESULTS: Using human CRC cells that exhibit differential expression of Wnt/beta-catenin signaling, we demonstrate that treatment of CRC cells with dietary triterpene lupeol results in a dose-dependent (i) decrease in cell viability, (ii) induction of apoptosis, (iii) decrease in colonogenic potential, (iv) decrease in beta-catenin transcriptional activity, and (v) decrease in the expression of Wnt target genes.	Triterpenes	167-177	catenin beta 1	Homo sapiens	332-344
23125221-1	2013	The triterpene saponin ginsenoside Rh2 has been shown to have antiproliferative effects on various cancer cells.	Triterpenes	4-14	Rh associated glycoprotein	Homo sapiens	35-38
23966082-8	2013	The purpose of this study was to examine the anti-lung cancer activity of triterpenes of GLK in vitro and in vivo and to explore their anti-lung cancer effects and potential mechanisms.	Triterpenes	74-85	galactokinase 1	Mus musculus	89-92
23966082-10	2013	The IC50 of triterpenes of GLK on A549 cells was 24.63 mug/mL.	Triterpenes	12-23	galactokinase 1	Mus musculus	27-30
23966082-11	2013	Triterpenes of GLK could significantly inhibit tumor growth in mice (30, 60 and 120 mg/kg).	Triterpenes	0-11	galactokinase 1	Mus musculus	15-18
23966082-15	2013	Triterpenes induced apoptosis by decreasing the expression of the antiapoptotic protein Bcl-2 and pro-caspase 9 and increasing the levels of cleaved-caspase 9.	Triterpenes	0-11	B cell leukemia/lymphoma 2	Mus musculus	88-93
23966082-15	2013	Triterpenes induced apoptosis by decreasing the expression of the antiapoptotic protein Bcl-2 and pro-caspase 9 and increasing the levels of cleaved-caspase 9.	Triterpenes	0-11	caspase 9	Mus musculus	102-111
23966082-15	2013	Triterpenes induced apoptosis by decreasing the expression of the antiapoptotic protein Bcl-2 and pro-caspase 9 and increasing the levels of cleaved-caspase 9.	Triterpenes	0-11	caspase 9	Mus musculus	149-158
23966082-16	2013	Our findings suggested that the triterpenes of GLK have anti-lung cancer activity in vitro and in vivo via enhancement of immunomodulation and induction of cell apoptosis.	Triterpenes	32-43	galactokinase 1	Mus musculus	47-50
23932918-13	2013	Moreover, this triterpene may exerts its antinociceptive effect mediated by the presence of cGMP and an additive synergism with 5HT1A receptors, but also an antagonistic activity towards TRPV1 receptors may be involved.	Triterpenes	15-25	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	187-192
23966082-7	2013	The triterpenes as main effective components of GLK have been found to be beneficial for the efficacy.	Triterpenes	4-15	galactokinase 1	Mus musculus	48-51
24502137-4	2013	The efficiency of the SPR assay was showed with 19 steroid and triterpene compounds, which were not investigated as potential ligands of CYP51A1.	Triterpenes	63-73	sepiapterin reductase	Homo sapiens	22-25
23588713-0	2013	Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7.	Triterpenes	0-11	matrix metallopeptidase 7	Homo sapiens	119-124
23621813-0	2013	Triterpenes from the aerial parts of Cimicifuga yunnanensis and their antiproliferative effects on p53(N236S) mouse embryonic fibroblasts.	Triterpenes	0-11	transformation related protein 53, pseudogene	Mus musculus	99-102
23725837-8	2013	Expression of VEGF protein in the salvianolic acid at 1.2 mg L(-1) group, was up-regulated as compared with notoginseng triterpenes group (P < 0.05).	Triterpenes	120-131	vascular endothelial growth factor A	Homo sapiens	14-18
23725837-9	2013	CONCLUSION: Salvianolic acid and notoginseng triterpenes can promote EA-hy926 cell proliferation, angiogenesis and expression of VEGF protein.	Triterpenes	45-56	vascular endothelial growth factor A	Homo sapiens	129-133
23474902-0	2013	Synthesis of novel triterpene and N-allylated/N-alkylated niacin hybrids as alpha-glucosidase inhibitors.	Triterpenes	19-29	sucrase-isomaltase	Homo sapiens	76-93
23099255-0	2013	The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice.	Triterpenes	80-90	mitogen-activated protein kinase 3	Mus musculus	16-22
22779802-0	2013	Synthesis and biological evaluation of novel pentacyclic triterpene derivatives as potential PPARgamma agonists.	Triterpenes	57-67	peroxisome proliferator-activated receptor gamma	Oryctolagus cuniculus	93-102
22779802-1	2013	Synthesis and biological evaluation of a novel series of substituted pentacyclic triterpene derivatives as potential PPARgamma  agoinsts and glycogen phosphorylase inhibitors have been described.	Triterpenes	81-91	peroxisome proliferator-activated receptor gamma	Oryctolagus cuniculus	117-126
22683870-3	2012	Previously, a triterpene 5beta,19-epoxy-25-methoxy-cucurbita-6,23-diene-3beta,19-diol (EMCD), purified from M. charantia L. wild variant WB24, was found to activate AMP-activated protein kinase (AMPK) and have a hypoglycaemic effect in TNF-alpha-treated FL83B cells.	Triterpenes	14-24	tumor necrosis factor	Mus musculus	236-245
22746536-0	2013	Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson"s disease.	Triterpenes	73-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	10-14
22746536-3	2013	AIMS: We evaluated whether the strategy of activation of Nrf2 and its downstream network of cytoprotective genes with small molecule synthetic triterpenoids (TP) attenuate MPTP-induced PD in mice.	Triterpenes	143-156	nuclear factor, erythroid derived 2, like 2	Mus musculus	57-61
22746536-3	2013	AIMS: We evaluated whether the strategy of activation of Nrf2 and its downstream network of cytoprotective genes with small molecule synthetic triterpenoids (TP) attenuate MPTP-induced PD in mice.	Triterpenes	158-160	nuclear factor, erythroid derived 2, like 2	Mus musculus	57-61
22746536-4	2013	RESULTS: We show that synthetic TP are thus far the most potent and direct activators of the Nrf2 pathway using a novel Neh2-luciferase reporter.	Triterpenes	32-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
22746536-6	2013	Oral administration of TP that were structurally modified to penetrate the brain-induced messenger RNA and protein levels for a battery of Nrf2-dependent cytoprotective genes reduced MPTP-induced oxidative stress and inflammation, and ameliorated dopaminergic neurotoxicity in mice.	Triterpenes	23-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	139-143
22746536-7	2013	The neuroprotective effect of these TP against MPTP neurotoxicity was dependent on Nrf2, since treatment with TP in Nrf2 knockout mice failed to block against MPTP neurotoxicity and induce Nrf2-dependent cytoprotective genes.	Triterpenes	36-38	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
22746536-7	2013	The neuroprotective effect of these TP against MPTP neurotoxicity was dependent on Nrf2, since treatment with TP in Nrf2 knockout mice failed to block against MPTP neurotoxicity and induce Nrf2-dependent cytoprotective genes.	Triterpenes	36-38	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
22746536-7	2013	The neuroprotective effect of these TP against MPTP neurotoxicity was dependent on Nrf2, since treatment with TP in Nrf2 knockout mice failed to block against MPTP neurotoxicity and induce Nrf2-dependent cytoprotective genes.	Triterpenes	36-38	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
22746536-7	2013	The neuroprotective effect of these TP against MPTP neurotoxicity was dependent on Nrf2, since treatment with TP in Nrf2 knockout mice failed to block against MPTP neurotoxicity and induce Nrf2-dependent cytoprotective genes.	Triterpenes	49-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
22746536-8	2013	INNOVATION: Extremely potent synthetic TP that are direct activators of the Nrf2 pathway block dopaminergic neurodegeneration in the MPTP mouse model of PD.	Triterpenes	39-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	76-80
22746536-9	2013	CONCLUSION: Our results indicate that activation of Nrf2/antioxidant response element (ARE) signaling by synthetic TP is directly associated with their neuroprotective effects against MPTP neurotoxicity and suggest that targeting the Nrf2/ARE pathway is a promising approach for therapeutic intervention in PD.	Triterpenes	115-117	nuclear factor, erythroid derived 2, like 2	Mus musculus	52-56
22746536-9	2013	CONCLUSION: Our results indicate that activation of Nrf2/antioxidant response element (ARE) signaling by synthetic TP is directly associated with their neuroprotective effects against MPTP neurotoxicity and suggest that targeting the Nrf2/ARE pathway is a promising approach for therapeutic intervention in PD.	Triterpenes	115-117	nuclear factor, erythroid derived 2, like 2	Mus musculus	234-238
23656282-5	2013	The triterpenes 1 and 2 were also tested for their antimicrobial activity against 15 strains of microorganisms, including fungi and bacteria, with the best minimal inhibitory concentration values ranging from 50.8 to 203.5 muM.	Triterpenes	4-15	latexin	Homo sapiens	223-226
22318938-4	2012	We report here cytotoxic effects of a novel OA-rich triterpene extract from mistletoe (V. album L., Santalaceae) solubilized by 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) on B16.F10 mouse melanoma cells.	Triterpenes	52-62	beta-carotene oxygenase 1	Mus musculus	168-175
22318938-5	2012	The 2-HP-beta-CD solubilized triterpene extract (STE) was highly cytotoxic by causing DNA fragmentation, followed by loss of membrane integrity and intracellular adenosine-5"-triphosphate (ATP).	Triterpenes	29-39	beta-carotene oxygenase 1	Mus musculus	9-16
22318938-7	2012	The solubilization by 2-HP-beta-CD allows a solvent-free application of triterpene extracts in the in vitro setting.	Triterpenes	72-82	beta-carotene oxygenase 1	Mus musculus	27-34
23162908-1	2012	After searching the transcriptome dataset of Panax notoginseng, one unique sequence Pn02086 encoding UDP-glucosyltransferase (UGT), which may be involved in triterpene saponin biosynthesis, was discovered.	Triterpenes	157-167	hydroquinone glucosyltransferase	Medicago truncatula	101-124
23162908-10	2012	Sequence alignment and phylogenetic analysis demonstrated that PnUGT1 had relative close relationship to the triterpene UDP-glucosyltransferase of Medicago truncatula (AAW56092), with the 66% similarity of conserved domain PSPG-box.	Triterpenes	109-119	hydroquinone glucosyltransferase	Medicago truncatula	120-143
22260389-7	2012	Triterpene-pretreated EAE-mice exhibited less leptin secretion, and switched cytokine production towards a Th2/regulatory profile, with lower levels of Th1 and Th17 cytokines and higher expression of Th2 cytokines in both serum and spinal cord.	Triterpenes	0-10	heart and neural crest derivatives expressed 2	Mus musculus	107-110
22731844-0	2012	Cycloartane-type triterpenes from the leaves of Homonoia riparia with VEGF-induced angiogenesis inhibitory activity.	Triterpenes	17-28	vascular endothelial growth factor A	Rattus norvegicus	70-74
22683342-3	2012	In this study, the triterpenes, alisol M 23-acetate and alisol A 23-acetate, were isolated from A. orientalis and further evaluated for their activity against FXR.	Triterpenes	19-30	nuclear receptor subfamily 1 group H member 4	Homo sapiens	159-162
22683342-4	2012	In the mammalian one-hybrid and transient transfection reporter assays, both triterpenes transactivated FXR to modulate promoter action including GAL4, SHP, CYP7A1, and PLTP promoters in dose-dependent manner, while they exhibited similar agonistic activity as chenodeoxycholic acid (CDCA), an endogenous FXR agonist.	Triterpenes	77-88	nuclear receptor subfamily 1 group H member 4	Homo sapiens	104-107
22683342-4	2012	In the mammalian one-hybrid and transient transfection reporter assays, both triterpenes transactivated FXR to modulate promoter action including GAL4, SHP, CYP7A1, and PLTP promoters in dose-dependent manner, while they exhibited similar agonistic activity as chenodeoxycholic acid (CDCA), an endogenous FXR agonist.	Triterpenes	77-88	galectin 4	Homo sapiens	146-150
22683342-4	2012	In the mammalian one-hybrid and transient transfection reporter assays, both triterpenes transactivated FXR to modulate promoter action including GAL4, SHP, CYP7A1, and PLTP promoters in dose-dependent manner, while they exhibited similar agonistic activity as chenodeoxycholic acid (CDCA), an endogenous FXR agonist.	Triterpenes	77-88	nuclear receptor subfamily 0 group B member 2	Homo sapiens	152-155
22683342-4	2012	In the mammalian one-hybrid and transient transfection reporter assays, both triterpenes transactivated FXR to modulate promoter action including GAL4, SHP, CYP7A1, and PLTP promoters in dose-dependent manner, while they exhibited similar agonistic activity as chenodeoxycholic acid (CDCA), an endogenous FXR agonist.	Triterpenes	77-88	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	157-163
22683342-4	2012	In the mammalian one-hybrid and transient transfection reporter assays, both triterpenes transactivated FXR to modulate promoter action including GAL4, SHP, CYP7A1, and PLTP promoters in dose-dependent manner, while they exhibited similar agonistic activity as chenodeoxycholic acid (CDCA), an endogenous FXR agonist.	Triterpenes	77-88	phospholipid transfer protein	Homo sapiens	169-173
22683342-4	2012	In the mammalian one-hybrid and transient transfection reporter assays, both triterpenes transactivated FXR to modulate promoter action including GAL4, SHP, CYP7A1, and PLTP promoters in dose-dependent manner, while they exhibited similar agonistic activity as chenodeoxycholic acid (CDCA), an endogenous FXR agonist.	Triterpenes	77-88	nuclear receptor subfamily 1 group H member 4	Homo sapiens	305-308
22260389-7	2012	Triterpene-pretreated EAE-mice exhibited less leptin secretion, and switched cytokine production towards a Th2/regulatory profile, with lower levels of Th1 and Th17 cytokines and higher expression of Th2 cytokines in both serum and spinal cord.	Triterpenes	0-10	negative elongation factor complex member C/D, Th1l	Mus musculus	152-155
22260389-7	2012	Triterpene-pretreated EAE-mice exhibited less leptin secretion, and switched cytokine production towards a Th2/regulatory profile, with lower levels of Th1 and Th17 cytokines and higher expression of Th2 cytokines in both serum and spinal cord.	Triterpenes	0-10	heart and neural crest derivatives expressed 2	Mus musculus	200-203
22260389-9	2012	In vitro, triterpenes inhibited ERK and rS6 phosphorylation and reduced the proliferative response, phagocytic properties and synthesis of proinflammatory mediators induced by the addition of inflammatory stimuli to microglia.	Triterpenes	10-21	mitogen-activated protein kinase 1	Mus musculus	32-35
22248180-0	2012	Inhibition of nuclear transcription factor-kappaB and activation of peroxisome proliferator-activated receptors in HepG2 cells by cucurbitane-type triterpene glycosides from Momordica charantia.	Triterpenes	147-157	nuclear factor kappa B subunit 1	Homo sapiens	14-49
22425978-4	2012	Squalene synthase catalyses dimerization of two farnesyl diphosphate (FPP) molecules into squalene, a key precursor for sterols and triterpenes.	Triterpenes	132-143	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	0-17
22975512-3	2012	Among the three major triterpene constituents isolated (i.e., alisol B, alisol B 23-acetate, alisol C 23-acetate) as active principles, alisol B and its 23-acetate strongly and significantly inhibited LT production and beta-hexosaminidase release between 1-10 microM.	Triterpenes	22-32	O-GlcNAcase	Rattus norvegicus	219-238
22553057-0	2012	A new lupane-type triterpene from the seeds of Panax ginseng with its inhibition of NF-kappaB.	Triterpenes	18-28	nuclear factor kappa B subunit 1	Homo sapiens	84-93
20814731-4	2012	Results showing that this triterpene induced DNA-fragmentation, activation of caspase-3 and cytochrome c release indicated that its activity is mediated by the activation of the intrinsic pathway of apoptosis.	Triterpenes	26-36	caspase 3	Homo sapiens	78-87
20814731-4	2012	Results showing that this triterpene induced DNA-fragmentation, activation of caspase-3 and cytochrome c release indicated that its activity is mediated by the activation of the intrinsic pathway of apoptosis.	Triterpenes	26-36	cytochrome c, somatic	Homo sapiens	92-104
22168134-3	2012	Furthermore, compound 32 possesses a rare triterpene skeleton with the cyclopropane ring fused onto C-1 and C-10, instead of C-9 and C-10.	Triterpenes	42-52	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	100-112
22168134-3	2012	Furthermore, compound 32 possesses a rare triterpene skeleton with the cyclopropane ring fused onto C-1 and C-10, instead of C-9 and C-10.	Triterpenes	42-52	homeobox C10	Homo sapiens	108-112
23209812-2	2012	Saikosaponin a (SSa), a triterpene saponin derived from Bupleurum chinensis DC., has been demonstrated to have significant antiepileptic activity in a variety of epilepsy models in vivo.	Triterpenes	24-34	tripartite motif containing 21	Homo sapiens	16-19
22844495-11	2012	Finally, cardiac hypertrophy, ventricular remodeling, fibrosis, and increases in myocyte area and brain natriuretic peptide levels observed in angiotensin II-infused mice were reduced in triterpene-treated animals.	Triterpenes	187-197	angiotensinogen	Rattus norvegicus	143-157
22844495-0	2012	DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.	Triterpenes	5-16	angiotensinogen	Rattus norvegicus	46-60
21651437-1	2011	With the exception of polysaccharides and triterpenes/triterpenoids compounds, fungal immunomodulatory protein (FIP), a small molecule protein, is also an important bioactive component with immune regulating activity.	Triterpenes	42-53	upstream transcription factor 2, c-fos interacting	Homo sapiens	112-115
22844495-3	2012	Therefore, the aim of the study was to investigate the preventive effects of the natural triterpenes erythrodiol and uvaol on the proliferation and collagen production induced by angiotensin II in cardiac myofibroblasts.	Triterpenes	89-100	angiotensinogen	Rattus norvegicus	179-193
22844495-7	2012	The presence of low doses of both triterpenes reduced the proliferation of cardiac myofibroblasts induced by angiotensin II.	Triterpenes	34-45	angiotensinogen	Rattus norvegicus	109-123
22312713-2	2011	Oleanolic acid, one of the most known triterpenes, was subjected to different chemical transformations within C-3 beta-hydroxyl group, a double bond between C-12 and C-13, and a carboxyl function at C-17 in order to obtain new derivatives.	Triterpenes	38-49	homeobox C13	Homo sapiens	166-170
22312713-2	2011	Oleanolic acid, one of the most known triterpenes, was subjected to different chemical transformations within C-3 beta-hydroxyl group, a double bond between C-12 and C-13, and a carboxyl function at C-17 in order to obtain new derivatives.	Triterpenes	38-49	cytokine like 1	Homo sapiens	199-203
21435752-0	2011	New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid beta aggregation.	Triterpenes	68-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	17-37
21889336-0	2011	Oleanane-type triterpene saponins from the bark of Aralia elata and their NF-kappaB inhibition and PPAR activation signal pathway.	Triterpenes	14-24	nuclear factor kappa B subunit 1	Homo sapiens	74-83
21435752-1	2011	New acetylcholinesterase inhibitors in the tetracyclic triterpene series were synthesized, tested in vitro for the inhibition of cholinesterases (different sources of AChE and BuChE) and for the ability to prevent AChE-induced Abeta aggregation.	Triterpenes	55-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-24
21561086-3	2011	In this study, we have examined AKR1B10 inhibition by seven pentacyclic triterpenes (1-7) that show potential anticancer properties.	Triterpenes	72-83	aldo-keto reductase family 1 member B10	Homo sapiens	32-39
22097093-8	2011	Preliminary phytochemical analysis of E2F2 extract revealed the presence of sterols, triterpenes and saponosids.	Triterpenes	85-96	E2F transcription factor 2	Homo sapiens	38-42
21453678-3	2011	Here, we showed that triterpenes-rich extract of antlered form of G. lucidum (G. lucidum AF) induces TNFalpha production in monocytic THP-1 cells.	Triterpenes	21-32	tumor necrosis factor	Homo sapiens	101-109
21453678-4	2011	Furthermore, the extract also synergized with lipopolysaccharide (LPS) to induce TNFalpha production in THP-1 cells, suggesting an immunostimulatory role of triterpenes-rich extract of G. lucidum AF.	Triterpenes	157-168	tumor necrosis factor	Homo sapiens	81-89
20717876-9	2011	These in vitro inhibitory potencies, which are within the range of those reported for two CYP3A inhibitory components in grapefruit juice, suggest that these triterpenes may have contributed to the midazolam-cranberry juice interaction observed in the clinical study.	Triterpenes	158-169	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-95
21376605-5	2011	Starting from the lead compounds glycyrrhetinic acid and the hydroxamic acid derivatives, novel triterpene type derivatives were synthesized and analyzed for their biological activity against overexpressed human 11beta-HSD1 and 11beta-HSD2 in cell lysates.	Triterpenes	96-106	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	212-239
20955150-0	2011	Triterpene derivatives as inhibitors of protein involved in the inflammatory process: molecules interfering with phospholipase A2, cycloxygenase, and lipoxygenase.	Triterpenes	0-10	phospholipase A2 group IB	Homo sapiens	113-162
20955150-7	2011	The present review describes anti-inflammatory triterpenes derivatives from plant and fungi reported during the last two decades in order to provide an account of this field of investigation, sorting compounds according to their targets, phospholipase A(2) (PLA(2)), cycloxygenase (COX), and lipoxygenase (LOX).	Triterpenes	47-58	phospholipase A2 group IB	Homo sapiens	238-256
20955150-7	2011	The present review describes anti-inflammatory triterpenes derivatives from plant and fungi reported during the last two decades in order to provide an account of this field of investigation, sorting compounds according to their targets, phospholipase A(2) (PLA(2)), cycloxygenase (COX), and lipoxygenase (LOX).	Triterpenes	47-58	phospholipase A2 group IB	Homo sapiens	258-264
21524306-0	2011	The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism.	Triterpenes	12-22	mitogen-activated protein kinase 8	Homo sapiens	87-90
21524306-0	2011	The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism.	Triterpenes	12-22	tumor protein p53	Homo sapiens	91-94
20732907-0	2010	Specific targeting of Wnt/beta-catenin signaling in human melanoma cells by a dietary triterpene lupeol.	Triterpenes	86-96	catenin beta 1	Homo sapiens	26-38
20980347-0	2011	Re: Specific targeting of Wnt/beta-catenin signaling in human melanoma cells by a dietary triterpene lupeol.	Triterpenes	90-100	catenin beta 1	Homo sapiens	30-42
21047661-1	2011	Triterpene saponins, pachanosides C1, E1, F1 and G1 (1-4), and bridgesides A1, C1, C2, D1, D2, E1 and E2 (5-11) were isolated from Echinopsis macrogona.	Triterpenes	0-10	complement C2	Homo sapiens	83-110
20851614-4	2010	Starting from the lead compound glycyrrhetinic acid, novel triterpene type derivatives were synthesized and analyzed for their biological activity against overexpressed human 11beta-HSD1 and 11beta-HSD2 in cell lysates.	Triterpenes	59-69	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	175-202
21088503-3	2011	The triterpene natural product Celastrol inhibits HSP90 and several pathways relevant to ErbB2-dependent oncogenesis including the NFkappaB pathway and the proteasome, and has shown promising activity in other cancer models.	Triterpenes	4-14	heat shock protein 90 alpha family class A member 1	Homo sapiens	50-55
21088503-3	2011	The triterpene natural product Celastrol inhibits HSP90 and several pathways relevant to ErbB2-dependent oncogenesis including the NFkappaB pathway and the proteasome, and has shown promising activity in other cancer models.	Triterpenes	4-14	erb-b2 receptor tyrosine kinase 2	Homo sapiens	89-94
21088503-3	2011	The triterpene natural product Celastrol inhibits HSP90 and several pathways relevant to ErbB2-dependent oncogenesis including the NFkappaB pathway and the proteasome, and has shown promising activity in other cancer models.	Triterpenes	4-14	nuclear factor kappa B subunit 1	Homo sapiens	131-139
21142067-4	2011	Moreover, although all tested triterpenes did not show free radical scavenging activity using ABTS and DPPH assays, they protected against oxidative DNA damage at the concentration 10 muM.	Triterpenes	30-41	latexin	Homo sapiens	184-187
22355716-3	2011	Derivatives of the natural triterpene oleanolic acid, namely CDDO-trifluoroethyl-amide (CDDO-TFEA), completely suppressed disease in a murine model of MS, experimental autoimmune encephalomyelitis (EAE), by inhibiting Th1 and Th17 mRNA and cytokine production.	Triterpenes	27-37	negative elongation factor complex member C/D, Th1l	Mus musculus	218-221
20924896-0	2010	New triterpenes from Salacia hainanensis Chun et How with alpha-glucosidase inhibitory activity.	Triterpenes	4-15	sucrase-isomaltase	Homo sapiens	58-75
20702092-0	2010	Lanostane triterpenes from Ganoderma lucidum suppress the adipogenesis in 3T3-L1 cells through down-regulation of SREBP-1c.	Triterpenes	10-21	sterol regulatory element binding transcription factor 1	Mus musculus	114-122
20399852-0	2010	The Nrf2 pathway as a potential therapeutic target for Huntington disease A commentary on "Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington disease".	Triterpenes	91-104	nuclear factor, erythroid derived 2, like 2	Mus musculus	4-8
20338236-5	2010	Synthetic triterpenoids, which are derived from 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic acid (CDDO) activate the Nrf2/ARE pathway and reduce oxidative stress in animal models of neurodegenerative diseases.	Triterpenes	10-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
20154087-0	2010	Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.	Triterpenes	13-23	TNF superfamily member 10	Homo sapiens	34-39
20347305-1	2010	Cucurbitane-type triterpenes, cucurbitacins B and E, were reported to exhibit cytotoxic effects in several cell lines mediated by JAK/STAT3 signaling.	Triterpenes	17-28	signal transducer and activator of transcription 3	Homo sapiens	134-139
20154087-3	2010	When examined for its mechanism, we found that the triterpene down-regulated the expression of cell survival proteins including cFLIP, IAP-1, Bcl-2, Bcl-xL, survivin, and XIAP and up-regulated Bax expression.	Triterpenes	51-61	baculoviral IAP repeat containing 3	Homo sapiens	135-140
20154087-3	2010	When examined for its mechanism, we found that the triterpene down-regulated the expression of cell survival proteins including cFLIP, IAP-1, Bcl-2, Bcl-xL, survivin, and XIAP and up-regulated Bax expression.	Triterpenes	51-61	BCL2 apoptosis regulator	Homo sapiens	142-147
20154087-3	2010	When examined for its mechanism, we found that the triterpene down-regulated the expression of cell survival proteins including cFLIP, IAP-1, Bcl-2, Bcl-xL, survivin, and XIAP and up-regulated Bax expression.	Triterpenes	51-61	BCL2 like 1	Homo sapiens	149-155
20154087-3	2010	When examined for its mechanism, we found that the triterpene down-regulated the expression of cell survival proteins including cFLIP, IAP-1, Bcl-2, Bcl-xL, survivin, and XIAP and up-regulated Bax expression.	Triterpenes	51-61	X-linked inhibitor of apoptosis	Homo sapiens	171-175
20154087-3	2010	When examined for its mechanism, we found that the triterpene down-regulated the expression of cell survival proteins including cFLIP, IAP-1, Bcl-2, Bcl-xL, survivin, and XIAP and up-regulated Bax expression.	Triterpenes	51-61	BCL2 associated X, apoptosis regulator	Homo sapiens	193-196
19716700-0	2009	Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells.	Triterpenes	14-25	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	147-151
19683515-0	2009	Lupeol triterpene, a novel diet-based microtubule targeting agent: disrupts survivin/cFLIP activation in prostate cancer cells.	Triterpenes	7-17	CASP8 and FADD like apoptosis regulator	Homo sapiens	85-90
19651243-2	2009	In the present study we evaluated the anti-inflammatory effects of the triterpene extract from G. lucidum (GLT) in LPS-stimulated macrophages.	Triterpenes	71-81	toll-like receptor 4	Mus musculus	115-118
19543395-8	2009	Moreover, triterpene exposure resulted in the production of reactive oxygen species (ROS) with loss of mitochondrial transmembrane potential, and correlated with the activation of c-Jun N-terminal kinases (JNK).	Triterpenes	10-20	mitogen-activated protein kinase 8	Homo sapiens	180-204
19445469-1	2009	The triterpene product profile is reported for At5g36150 (PEN3), the last unexamined oxidosqualene cyclase in the reference plant Arabidopsis thaliana.	Triterpenes	4-14	putative pentacyclic triterpene synthase 3	Arabidopsis thaliana	58-62
19543395-8	2009	Moreover, triterpene exposure resulted in the production of reactive oxygen species (ROS) with loss of mitochondrial transmembrane potential, and correlated with the activation of c-Jun N-terminal kinases (JNK).	Triterpenes	10-20	mitogen-activated protein kinase 8	Homo sapiens	206-209
19233958-1	2009	Lupeol, a dietary triterpene, was shown to decrease serum prostate-specific antigen levels and inhibit the tumorigenicity of prostate cancer (CaP) cells in vivo.	Triterpenes	18-28	kallikrein related peptidase 3	Homo sapiens	58-83
19551732-0	2009	Acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of chinese tea plant (Camellia sinensis).	Triterpenes	23-33	pancreatic lipase	Mus musculus	114-131
19484125-0	2009	Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.	Triterpenes	31-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
19484125-2	2009	We tested neuroprotective effects of the synthetic triterpenoid CDDO-MA, a potent activator of the Nrf2/ARE signaling.	Triterpenes	51-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
19484125-7	2009	Our results indicate that the CDDO-MA renders its neuroprotective effects through its potent activation of the Nrf2/ARE pathway, and suggest that triterpenoids may be beneficial for the treatment of neurodegenerative diseases like Parkinson"s disease and Huntington"s disease.	Triterpenes	146-159	NFE2 like bZIP transcription factor 2	Rattus norvegicus	111-115
19415934-2	2009	One of these genes, Afu4g14770, designated AfuOSC3, is clustered with genes of cytochrome P450 monooxygenases (P450s), a short-chain dehydrogenase/reductase (SDR), and acyltransferases, which presumably function in triterpene tailoring steps, suggesting that this gene cluster codes for helvolic acid biosynthesis.	Triterpenes	215-225	short-chain dehydrogenase/reductase	Saccharomyces cerevisiae S288C	121-156
19415934-2	2009	One of these genes, Afu4g14770, designated AfuOSC3, is clustered with genes of cytochrome P450 monooxygenases (P450s), a short-chain dehydrogenase/reductase (SDR), and acyltransferases, which presumably function in triterpene tailoring steps, suggesting that this gene cluster codes for helvolic acid biosynthesis.	Triterpenes	215-225	short-chain dehydrogenase/reductase	Saccharomyces cerevisiae S288C	158-161
19415934-6	2009	To further identify the function of triterpene tailoring enzymes, four P450 genes (CYP5081A1-D1) and a SDR gene (AfuSDR1) in the cluster were each coexpressed with AfuOSC3 in yeast.	Triterpenes	36-46	short-chain dehydrogenase/reductase	Saccharomyces cerevisiae S288C	103-106
18942087-1	2009	This paper addresses a comprehensive and comparative study of six phytochemical extraction methods for triterpenes from the fruiting body of Ganoderma spp.	Triterpenes	103-114	histocompatibility minor 13	Homo sapiens	151-154
18842418-8	2008	These pentacyclic triterpene inhibitors showed an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotoxicity against cancer cells.	Triterpenes	18-28	GLI family zinc finger 1	Homo sapiens	84-87
19176377-0	2009	Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells.	Triterpenes	42-52	CASP8 and FADD like apoptosis regulator	Homo sapiens	15-20
19176377-2	2009	This study was designed to investigate the effect of lupeol, a dietary triterpene, on (a) apoptosis of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) therapy-resistant PaC cells overexpressing cFLIP and (b) growth of human pancreatic tumor xenografts in vivo.	Triterpenes	71-81	TNF superfamily member 10	Homo sapiens	160-165
19585625-0	2009	Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol.	Triterpenes	111-121	heat shock protein 90 alpha family class A member 1	Homo sapiens	63-68
19585625-0	2009	Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol.	Triterpenes	111-121	cell division cycle 37, HSP90 cochaperone	Homo sapiens	69-74
18842418-8	2008	These pentacyclic triterpene inhibitors showed an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotoxicity against cancer cells.	Triterpenes	18-28	BCL2 apoptosis regulator	Homo sapiens	126-130
18166740-2	2008	Ganoderic acid D (GAD) is one of the major components in Ganoderma triterpenes.	Triterpenes	67-78	glutamate decarboxylase 1	Homo sapiens	0-16
18425349-1	2008	Structurally related lanostane-type triterpenes, ganoderic acid A, F and H (GA-A, GA-F, GA-H), were identified in an oriental medicinal mushroom Ganoderma lucidum.	Triterpenes	36-47	alpha glucosidase	Homo sapiens	76-80
18425349-1	2008	Structurally related lanostane-type triterpenes, ganoderic acid A, F and H (GA-A, GA-F, GA-H), were identified in an oriental medicinal mushroom Ganoderma lucidum.	Triterpenes	36-47	guanine deaminase	Homo sapiens	88-92
18425349-5	2008	Furthermore, the activity of ganoderic acids is linked to the hydroxylation in the position 7 and 15 (GA-A) and 3 (GA-H) in their triterpene lanostane structure.	Triterpenes	130-140	alpha glucosidase	Homo sapiens	102-106
18425349-5	2008	Furthermore, the activity of ganoderic acids is linked to the hydroxylation in the position 7 and 15 (GA-A) and 3 (GA-H) in their triterpene lanostane structure.	Triterpenes	130-140	guanine deaminase	Homo sapiens	115-119
18236008-1	2008	Squalene synthase (SQS) catalyzes the condensation of two molecules of farnesyl diphosphate (FPP) to produce squalene (SQ), the first committed precursor for sterol, brassinosteroid, and triterpene biosynthesis.	Triterpenes	187-197	squalene synthase 1	Arabidopsis thaliana	0-17
18981621-2	2008	New taraxastane-type triterpene, punicanolic acid, with tumor necrosis factor-alpha inhibitory activity from the flowers of Punica granatum.	Triterpenes	21-31	tumor necrosis factor	Mus musculus	56-83
18166740-2	2008	Ganoderic acid D (GAD) is one of the major components in Ganoderma triterpenes.	Triterpenes	67-78	glutamate decarboxylase 1	Homo sapiens	18-21
18173125-0	2007	[Effect of nitrogen-containing derivatives of the plant triterpenes betulin and glycyrrhetic acid on the growth of MT-4, MOLT-4, CEM, and Hep G2 tumor cells].	Triterpenes	56-67	metallothionein 4	Homo sapiens	115-119
18199679-3	2008	The quinone methide triterpene celastrol, derived from a traditional Chinese medicinal herb, has numerous pharmacological properties, and it is a potent activator of the mammalian heat shock transcription factor HSF1.	Triterpenes	20-30	heat shock transcription factor 1	Homo sapiens	212-216
17902635-0	2007	New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.	Triterpenes	62-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	11-31
17705488-4	2007	By accessing an extraordinary repertoire of mechanistic pathways, BARS1 makes numerous skeletal types and deprotonates the carbocation intermediates at 14 different sites around rings A, B, C, D, and E. This undercurrent of structural and mechanistic diversity in a superficially accurate enzyme is incompatible with prevailing concepts of triterpene biosynthesis, which posit tight control over the mechanistic pathway through cation-pi interactions, with a single proton acceptor in a hydrophobic active site.	Triterpenes	340-350	baruol synthase 1	Arabidopsis thaliana	66-71
17661331-0	2007	Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum.	Triterpenes	34-45	tyrosinase	Homo sapiens	0-10
17917299-0	2007	Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis.	Triterpenes	119-129	hydroxy methylglutaryl CoA reductase 1	Arabidopsis thaliana	27-31
17917299-0	2007	Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis.	Triterpenes	119-129	3-hydroxy-3-methylglutaryl-CoA reductase 2	Arabidopsis thaliana	36-40
17917299-0	2007	Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis.	Triterpenes	119-129	hydroxy methylglutaryl CoA reductase 1	Arabidopsis thaliana	98-115
17917299-6	2007	We previously postulated that the 50% decrease in the sterol content of hmg1, as compared to that in the wild type, was a cause of these phenotypes, but comprehensive triterpene profiles of these mutants had not yet been determined.	Triterpenes	167-177	hydroxy methylglutaryl CoA reductase 1	Arabidopsis thaliana	72-76
17917299-7	2007	Here, we present the triterpene profiles of hmg1 and hmg2.	Triterpenes	21-31	hydroxy methylglutaryl CoA reductase 1	Arabidopsis thaliana	44-48
17917299-7	2007	Here, we present the triterpene profiles of hmg1 and hmg2.	Triterpenes	21-31	3-hydroxy-3-methylglutaryl-CoA reductase 2	Arabidopsis thaliana	53-57
17917299-10	2007	These results demonstrate that HMGR2 as well as HMGR1 is responsible for the biosynthesis of triterpenes in spite of the lack of visible phenotypes in hmg2.	Triterpenes	93-104	3-hydroxy-3-methylglutaryl-CoA reductase 2	Arabidopsis thaliana	31-36
17917299-10	2007	These results demonstrate that HMGR2 as well as HMGR1 is responsible for the biosynthesis of triterpenes in spite of the lack of visible phenotypes in hmg2.	Triterpenes	93-104	hydroxy methylglutaryl CoA reductase 1	Arabidopsis thaliana	48-53
17640301-0	2007	Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.	Triterpenes	41-51	ATP binding cassette subfamily B member 1	Homo sapiens	71-85
17640301-0	2007	Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.	Triterpenes	41-51	ATP binding cassette subfamily B member 1	Homo sapiens	87-92
17640301-7	2007	Overall, the present results indicate that sipholenol A efficiently inhibits the function of P-gp through direct interactions, and sipholane triterpenes are a new class of potential reversing agents for treatment of MDR in P-gp-overexpressing tumors.	Triterpenes	141-152	ATP binding cassette subfamily B member 1	Homo sapiens	223-227
17404266-2	2007	We recently found that a natural triterpene, ursolic acid (UA), enhanced MIF release from nonstimulated macrophages.	Triterpenes	33-43	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	73-76
17562851-5	2007	In addition, the triterpene reduced the production of interleukin-2, interleukin-4, interleukin-10, and interferon-gamma in human T lymphocytes, and it hampered the induction of the principal cyclins involved in the cell cycle, including A(1), B(1), D(2), and E(1).	Triterpenes	17-27	interleukin 2	Homo sapiens	54-67
17562851-5	2007	In addition, the triterpene reduced the production of interleukin-2, interleukin-4, interleukin-10, and interferon-gamma in human T lymphocytes, and it hampered the induction of the principal cyclins involved in the cell cycle, including A(1), B(1), D(2), and E(1).	Triterpenes	17-27	interleukin 4	Homo sapiens	69-82
17562851-5	2007	In addition, the triterpene reduced the production of interleukin-2, interleukin-4, interleukin-10, and interferon-gamma in human T lymphocytes, and it hampered the induction of the principal cyclins involved in the cell cycle, including A(1), B(1), D(2), and E(1).	Triterpenes	17-27	interleukin 10	Homo sapiens	84-98
17562851-5	2007	In addition, the triterpene reduced the production of interleukin-2, interleukin-4, interleukin-10, and interferon-gamma in human T lymphocytes, and it hampered the induction of the principal cyclins involved in the cell cycle, including A(1), B(1), D(2), and E(1).	Triterpenes	17-27	interferon gamma	Homo sapiens	104-120
17855663-8	2007	Moreover, knockdown of SHP-1 by small interfering RNA suppressed the induction of SHP-1 and reversed the inhibition of STAT3 activation, thereby indicating the critical role of SHP-1 in the action of this triterpene.	Triterpenes	205-215	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	23-28
17440087-6	2007	Furthermore, we showed that caspase-3 is activated as a consequence of triterpene treatment.	Triterpenes	71-81	caspase 3	Homo sapiens	28-37
17855663-8	2007	Moreover, knockdown of SHP-1 by small interfering RNA suppressed the induction of SHP-1 and reversed the inhibition of STAT3 activation, thereby indicating the critical role of SHP-1 in the action of this triterpene.	Triterpenes	205-215	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	82-87
17855663-8	2007	Moreover, knockdown of SHP-1 by small interfering RNA suppressed the induction of SHP-1 and reversed the inhibition of STAT3 activation, thereby indicating the critical role of SHP-1 in the action of this triterpene.	Triterpenes	205-215	signal transducer and activator of transcription 3	Homo sapiens	119-124
17855663-8	2007	Moreover, knockdown of SHP-1 by small interfering RNA suppressed the induction of SHP-1 and reversed the inhibition of STAT3 activation, thereby indicating the critical role of SHP-1 in the action of this triterpene.	Triterpenes	205-215	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	82-87
17404266-5	2007	This triterpene also strikingly induced the activation of p38 MAPK and ERK1/2 together with that of upstream kinases.	Triterpenes	5-15	mitogen-activated protein kinase 14	Mus musculus	58-66
17404266-5	2007	This triterpene also strikingly induced the activation of p38 MAPK and ERK1/2 together with that of upstream kinases.	Triterpenes	5-15	mitogen-activated protein kinase 3	Mus musculus	71-77
17107079-0	2006	Stereochemical course in water addition during LUP1-catalyzed triterpene cyclization.	Triterpenes	62-72	lupeol synthase 1	Arabidopsis thaliana	47-51
17270224-0	2007	alpha-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae).	Triterpenes	41-52	sucrase-isomaltase	Homo sapiens	0-17
16935966-5	2007	A potential therapeutic avenue could be offered by bypassing the inhibition of the enzyme delta-6-desaturase by treatment with virgin cold-pressed non-raffinated evening primrose oil, which would supply gamma-linolenic acid and lipophilic pentacyclic triterpenes, and with eicosapentaenoic acid.	Triterpenes	251-262	fatty acid desaturase 2	Homo sapiens	90-108
16935966-6	2007	The gamma-linolenic acid can readily be converted into dihomo-gamma-linolenic acid and thence arachidonic acid, while triterpenes have important free radical scavenging, cyclo-oxygenase and neutrophil elastase inhibitory activities.	Triterpenes	118-129	elastase, neutrophil expressed	Homo sapiens	190-209
17190448-0	2006	Sodwanone and yardenone triterpenes from a South African species of the marine sponge Axinella inhibit hypoxia-inducible factor-1 (HIF-1) activation in both breast and prostate tumor cells.	Triterpenes	24-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-129
17190448-0	2006	Sodwanone and yardenone triterpenes from a South African species of the marine sponge Axinella inhibit hypoxia-inducible factor-1 (HIF-1) activation in both breast and prostate tumor cells.	Triterpenes	24-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-136
16478469-4	2006	To mine these hydroxylases from cytochrome P450 genes, five genes (CYP71D8, CYP82A2, CYP82A3, CYP82A4 and CYP93E1) reported to be elicitor-inducible genes in Glycine max expressed sequence tags (EST), were amplified by PCR, and screened for their ability to hydroxylate triterpenes (beta-amyrin or sophoradiol) by heterologous expression in the yeast Saccharomyces cerevisiae.	Triterpenes	270-281	cytochrome P450 71D8	Glycine max	67-74
17136324-9	2006	CONCLUSION: These Results suggest that down-regulation of MCP-1 is the main mechanism for antiatherogenic activity of triterpenes and MCP-1 might play important roles in the development of atherosclerosis and xanthoma.	Triterpenes	118-129	mast cell protease 1	Mus musculus	58-63
16478469-4	2006	To mine these hydroxylases from cytochrome P450 genes, five genes (CYP71D8, CYP82A2, CYP82A3, CYP82A4 and CYP93E1) reported to be elicitor-inducible genes in Glycine max expressed sequence tags (EST), were amplified by PCR, and screened for their ability to hydroxylate triterpenes (beta-amyrin or sophoradiol) by heterologous expression in the yeast Saccharomyces cerevisiae.	Triterpenes	270-281	cytochrome P450 82A2	Glycine max	76-83
16478469-4	2006	To mine these hydroxylases from cytochrome P450 genes, five genes (CYP71D8, CYP82A2, CYP82A3, CYP82A4 and CYP93E1) reported to be elicitor-inducible genes in Glycine max expressed sequence tags (EST), were amplified by PCR, and screened for their ability to hydroxylate triterpenes (beta-amyrin or sophoradiol) by heterologous expression in the yeast Saccharomyces cerevisiae.	Triterpenes	270-281	cytochrome P450 82A3	Glycine max	85-92
16478469-4	2006	To mine these hydroxylases from cytochrome P450 genes, five genes (CYP71D8, CYP82A2, CYP82A3, CYP82A4 and CYP93E1) reported to be elicitor-inducible genes in Glycine max expressed sequence tags (EST), were amplified by PCR, and screened for their ability to hydroxylate triterpenes (beta-amyrin or sophoradiol) by heterologous expression in the yeast Saccharomyces cerevisiae.	Triterpenes	270-281	cytochrome P450 82A4	Glycine max	94-101
16478469-4	2006	To mine these hydroxylases from cytochrome P450 genes, five genes (CYP71D8, CYP82A2, CYP82A3, CYP82A4 and CYP93E1) reported to be elicitor-inducible genes in Glycine max expressed sequence tags (EST), were amplified by PCR, and screened for their ability to hydroxylate triterpenes (beta-amyrin or sophoradiol) by heterologous expression in the yeast Saccharomyces cerevisiae.	Triterpenes	270-281	beta-amyrin 24-hydroxylase	Glycine max	106-113
16188240-4	2005	Further, the triterpene strikingly induced activation of mitogen-activated protein kinase kinase 1/2 (MEK1/2) and extracellular signal-regulated kinase 1/2 (ERK1/2) within 30min, whereas no phosphorylation of p38 MAPK or JNK protein was observed.	Triterpenes	13-23	mitogen-activated protein kinase kinase 1	Mus musculus	57-100
16462051-0	2006	Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ.	Triterpenes	61-72	acetyl-CoA acetyltransferase 1	Homo sapiens	6-10
16462051-0	2006	Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ.	Triterpenes	61-72	acetyl-CoA acetyltransferase 1	Homo sapiens	17-21
16454745-6	2006	Thus we determined the effect of structurally unrelated diterpenes, triterpenes and carotenoids on reversal of multidrug resistance in MDR-1 gene-transfected L1210 mouse lymphoma cells and MDR mediated multidrug resistance of human breast cancer cells MDA-MB-231 (HTB-26) and MCF-7.	Triterpenes	68-79	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	135-140
16188240-4	2005	Further, the triterpene strikingly induced activation of mitogen-activated protein kinase kinase 1/2 (MEK1/2) and extracellular signal-regulated kinase 1/2 (ERK1/2) within 30min, whereas no phosphorylation of p38 MAPK or JNK protein was observed.	Triterpenes	13-23	mitogen-activated protein kinase kinase 1	Mus musculus	102-108
16188240-4	2005	Further, the triterpene strikingly induced activation of mitogen-activated protein kinase kinase 1/2 (MEK1/2) and extracellular signal-regulated kinase 1/2 (ERK1/2) within 30min, whereas no phosphorylation of p38 MAPK or JNK protein was observed.	Triterpenes	13-23	mitogen-activated protein kinase 3	Mus musculus	114-155
16188240-4	2005	Further, the triterpene strikingly induced activation of mitogen-activated protein kinase kinase 1/2 (MEK1/2) and extracellular signal-regulated kinase 1/2 (ERK1/2) within 30min, whereas no phosphorylation of p38 MAPK or JNK protein was observed.	Triterpenes	13-23	mitogen-activated protein kinase 3	Mus musculus	157-163
16188240-4	2005	Further, the triterpene strikingly induced activation of mitogen-activated protein kinase kinase 1/2 (MEK1/2) and extracellular signal-regulated kinase 1/2 (ERK1/2) within 30min, whereas no phosphorylation of p38 MAPK or JNK protein was observed.	Triterpenes	13-23	mitogen-activated protein kinase 1	Mus musculus	213-217
16188240-4	2005	Further, the triterpene strikingly induced activation of mitogen-activated protein kinase kinase 1/2 (MEK1/2) and extracellular signal-regulated kinase 1/2 (ERK1/2) within 30min, whereas no phosphorylation of p38 MAPK or JNK protein was observed.	Triterpenes	13-23	mitogen-activated protein kinase 8	Mus musculus	221-224
15964027-9	2005	These results suggest that the triterpene mixture, alpha- and beta-amyrin has an analgesia inducing effect, possibly involving vanilloid receptor (TRPV1) and an opioid mechanism.	Triterpenes	31-41	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	147-152
15611276-6	2005	Instead, both pentacyclic triterpenes inhibited the LPS-induced degradation of IkappaBalpha, as well as phosphorylation of p65 at Ser(536) and its nuclear translocation.	Triterpenes	26-37	NFKB inhibitor alpha	Homo sapiens	79-91
15605242-2	2005	to methyl jasmonate (MeJA) resulted in up to 50-fold induction of transcripts encoding the key triterpene biosynthetic enzyme beta-amyrin synthase (betaAS; EC 5.4.99.-).	Triterpenes	95-105	beta-amyrin synthase	Medicago truncatula	126-146
15605242-2	2005	to methyl jasmonate (MeJA) resulted in up to 50-fold induction of transcripts encoding the key triterpene biosynthetic enzyme beta-amyrin synthase (betaAS; EC 5.4.99.-).	Triterpenes	95-105	beta-amyrin synthase	Medicago truncatula	148-154
15922841-3	2005	The SAR revealed that the triterpenes possessing two hydrogen-bond forming groups (an H-donor and a carbonyl group) at positions 3 and 28 exhibit cytotoxic activity.	Triterpenes	26-37	sarcosine dehydrogenase	Homo sapiens	4-7
15626723-0	2005	Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells.	Triterpenes	16-26	mitogen-activated protein kinase 1	Homo sapiens	132-135
15798995-4	2005	One triterpene glycoside, quadranoside I, and two triterpenes, betulinic and sericic acids, exhibited mild inhibitory activity on the isolated PDE4 isozyme.	Triterpenes	50-61	phosphodiesterase 4A	Homo sapiens	143-147
15050633-3	2004	Through bioassay-guided separation using the inhibitory activity against pancreatic lipase activity, 4 abietan-type diterpenes (carnosic acid, carnosol, royleanonic acid, 7-methoxyrosmanol) and a triterpene (oleanolic acid) were isolated from the active fraction.	Triterpenes	196-206	pancreatic lipase	Mus musculus	73-90
17191907-1	2004	Nine new isoxuxuarine-type triterpene dimers, named isoxuxuarines B alpha (1), B beta (2), 7,8-dihydro-B alpha (3), C alpha (4), C beta (5), 7,8-dihydro-C alpha (6), D alpha (7), D beta (8), and 7,8-dihydro-D alpha (9), were isolated from the South American medicinal plant "xuxua" (Maytenus chuchuhuasca).	Triterpenes	27-37	tubulin alpha 1a	Homo sapiens	66-77
15478202-1	2004	Different types of triterpenes including saponins and aglycons were evaluated for their ability to inhibit [3H] BQ-123 and [3H] angiotensin II binding to the human endothelin 1 ETA and angiotensin II AT1 receptors, respectively.	Triterpenes	19-30	angiotensinogen	Homo sapiens	128-142
15478202-1	2004	Different types of triterpenes including saponins and aglycons were evaluated for their ability to inhibit [3H] BQ-123 and [3H] angiotensin II binding to the human endothelin 1 ETA and angiotensin II AT1 receptors, respectively.	Triterpenes	19-30	angiotensinogen	Homo sapiens	185-199
15280961-2	2004	The first synthesis of mispyric acid (1), an inhibitor of DNA polymerase beta with a novel triterpene skeleton, was achieved by starting from isoprene (2), geraniol (6) and 1,5-dimethoxy-1,4-cyclohexadiene (14).	Triterpenes	91-101	DNA polymerase beta	Homo sapiens	58-77
14729014-2	2004	These lipophilic pentacyclic triterpenes have free radical scavenging, cyclooxygenase and neutrophil elastase inhibitory activities, and are therefore likely to be of benefit to human health.	Triterpenes	29-40	elastase, neutrophil expressed	Homo sapiens	90-109
14871314-13	2004	These findings suggest that HMG1 plays a critical role in triterpene biosynthesis, and that sterols and/or triterpenoids contribute to cell elongation, senescence, and fertility.	Triterpenes	58-68	hydroxy methylglutaryl CoA reductase 1	Arabidopsis thaliana	28-32
12745084-1	2003	We found that some triterpene compounds could not only selectively inhibit the activities of mammalian DNA polymerase alpha (pol alpha) and beta (pol beta), but could also potently inhibit DNA topoisomerase II (topo II) [Biochem.	Triterpenes	19-29	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	103-123
14519924-3	2003	Micranoic acids A and B represent a new group of triterpenes in which the entire C-17 side chain has lost.	Triterpenes	49-60	cytokine like 1	Homo sapiens	81-85
14561730-8	2003	The phosphorylation of p38 MAPK was detected on the addition of 1 microM lupeone, another lupane triterpene, but was not induced by 1 microM lupeol.	Triterpenes	97-107	mitogen-activated protein kinase 14	Mus musculus	23-31
14561730-9	2003	These results suggested that lupeol induced B16 2F2 cell differentiation through activation of p38 MAPK, and that the structural differences at C-3 of lupane triterpenes played an important role in the activation of p38 MAPK.	Triterpenes	158-169	mitogen-activated protein kinase 14	Mus musculus	216-224
12745084-5	2003	The natural triterpenes with a carboxyl group equally inhibited the activities of pol alpha, pol beta, and topo II, while the olide-type triterpenes with a ketone group suppressed the activities of pol beta and topo II, but not pol alpha.	Triterpenes	137-148	DNA polymerase beta	Homo sapiens	198-206
12745084-1	2003	We found that some triterpene compounds could not only selectively inhibit the activities of mammalian DNA polymerase alpha (pol alpha) and beta (pol beta), but could also potently inhibit DNA topoisomerase II (topo II) [Biochem.	Triterpenes	19-29	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	125-134
12745084-1	2003	We found that some triterpene compounds could not only selectively inhibit the activities of mammalian DNA polymerase alpha (pol alpha) and beta (pol beta), but could also potently inhibit DNA topoisomerase II (topo II) [Biochem.	Triterpenes	19-29	DNA polymerase beta	Homo sapiens	146-154
12745084-5	2003	The natural triterpenes with a carboxyl group equally inhibited the activities of pol alpha, pol beta, and topo II, while the olide-type triterpenes with a ketone group suppressed the activities of pol beta and topo II, but not pol alpha.	Triterpenes	137-148	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	228-237
12745084-8	2003	130 (2001) 657], pol beta and topo II have a three-dimensionally similar triterpene-binding region, which is a pocket in which specific compounds can insert.	Triterpenes	73-83	DNA polymerase beta	Homo sapiens	17-25
12745084-5	2003	The natural triterpenes with a carboxyl group equally inhibited the activities of pol alpha, pol beta, and topo II, while the olide-type triterpenes with a ketone group suppressed the activities of pol beta and topo II, but not pol alpha.	Triterpenes	12-23	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	82-91
12745084-5	2003	The natural triterpenes with a carboxyl group equally inhibited the activities of pol alpha, pol beta, and topo II, while the olide-type triterpenes with a ketone group suppressed the activities of pol beta and topo II, but not pol alpha.	Triterpenes	12-23	DNA polymerase beta	Homo sapiens	93-101
12183079-0	2002	Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells.	Triterpenes	16-26	tumor protein p53	Homo sapiens	108-111
12762796-3	2003	This appears to be the first report of the natural occurrence of euphane/tirucallane-type triterpenes with a ketone at C-7.	Triterpenes	90-101	complement C7 S homeolog	Xenopus laevis	119-122
12492844-3	2002	Mining M. truncatula EST data sets led to the identification of sequences putatively encoding three early enzymes of triterpene aglycone formation: squalene synthase (SS), squalene epoxidase (SE), and beta-amyrin synthase (beta-AS).	Triterpenes	117-127	squalene synthase 2	Medicago truncatula	148-165
12492844-3	2002	Mining M. truncatula EST data sets led to the identification of sequences putatively encoding three early enzymes of triterpene aglycone formation: squalene synthase (SS), squalene epoxidase (SE), and beta-amyrin synthase (beta-AS).	Triterpenes	117-127	squalene monooxygenase SE1	Medicago truncatula	172-190
12492844-3	2002	Mining M. truncatula EST data sets led to the identification of sequences putatively encoding three early enzymes of triterpene aglycone formation: squalene synthase (SS), squalene epoxidase (SE), and beta-amyrin synthase (beta-AS).	Triterpenes	117-127	beta-amyrin synthase	Medicago truncatula	201-221
12492844-3	2002	Mining M. truncatula EST data sets led to the identification of sequences putatively encoding three early enzymes of triterpene aglycone formation: squalene synthase (SS), squalene epoxidase (SE), and beta-amyrin synthase (beta-AS).	Triterpenes	117-127	beta-amyrin synthase	Medicago truncatula	223-230
12492844-6	2002	Transcripts encoding beta-AS, SS and one form of SE were strongly and co-ordinately induced, associated with accumulation of triterpenes, upon exposure of M. truncatula cell suspension cultures to methyl jasmonate.	Triterpenes	125-136	beta-amyrin synthase	Medicago truncatula	21-28
11807966-3	2002	The isolated triterpenes were tested for hypoglycaemic activity in normal and alloxman-diabetic CD1 mice 25-30 g at a dose of 50 mg/kg body weight.	Triterpenes	13-24	CD1 antigen complex	Mus musculus	96-99
11605850-6	2001	Further studies are needed to fully characterize whether these triterpene glycosides as well as other components of black cohosh in this plant extract bind to the estrogen receptor alpha (ER-alpha).	Triterpenes	63-73	estrogen receptor 1	Homo sapiens	163-186
11735581-1	2001	[structure: see text] Bioassay-guided fractionation of the plant Acacia aulacocarpa, guided by a bioassay for Tie2 tyrosine kinase activity, yielded the novel triterpene 3,21-dioxo-olean-18-en-oic acid (1) as the first naturally occurring non-protein inhibitor of Tie2 kinase.	Triterpenes	159-169	TEK receptor tyrosine kinase	Homo sapiens	110-114
11735581-1	2001	[structure: see text] Bioassay-guided fractionation of the plant Acacia aulacocarpa, guided by a bioassay for Tie2 tyrosine kinase activity, yielded the novel triterpene 3,21-dioxo-olean-18-en-oic acid (1) as the first naturally occurring non-protein inhibitor of Tie2 kinase.	Triterpenes	159-169	TEK receptor tyrosine kinase	Homo sapiens	264-268
11605850-6	2001	Further studies are needed to fully characterize whether these triterpene glycosides as well as other components of black cohosh in this plant extract bind to the estrogen receptor alpha (ER-alpha).	Triterpenes	63-73	estrogen receptor 1	Homo sapiens	188-196
11572998-4	2001	This study examines the effect of a triterpene mixture (F094) and a single molecular species (avicin G) isolated from the mixture on tumor necrosis factor (TNF)-induced activation of nuclear transcription factor-kappaB (NF-kappaB) in Jurkat cells (human T cell leukemia).	Triterpenes	36-46	tumor necrosis factor	Homo sapiens	156-159
10650080-3	2000	Among those compounds, quadrangularic acids F (1), G (2), and H (4) and 24-epiquadrangularic acid G (3) are the first examples of cycloartane-type triterpenes bearing carboxylic acid groups at both C-4 and C-20.	Triterpenes	147-158	complement C4A (Rodgers blood group)	Homo sapiens	198-201
11848513-7	2001	In summary, the triterpene saponins investigated contain an apoptotic-inducing activity in A431 cells and in the case of ursolic acid it is associated with proteolytic activation of caspase-3 and/or other similar caspases.	Triterpenes	16-26	caspase 3	Homo sapiens	182-191
10930257-1	2000	The Arabidopsis thaliana LUP1 gene encodes an enzyme that converts oxidosqualene to pentacyclic triterpenes.	Triterpenes	96-107	lupeol synthase 1	Arabidopsis thaliana	25-29
10666243-1	2000	The triterpene RPR103611 is an efficient inhibitor of membrane fusion mediated by the envelope proteins (Env, gp120-gp41) of CXCR4-dependent (X4) human immunodeficiency virus type 1 (HIV-1) strains, such as HIV-1(LAI) (LAI).	Triterpenes	4-14	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	110-115
11515584-2	2001	Triterpenes having the hemiketal structure at the A-ring, an acyloxy group at C-22 and/or ketone at C-3 showed potent anti-androgenic activity.	Triterpenes	0-11	complement C3	Homo sapiens	100-103
10783007-2	2000	5.4.99.-), an enzyme of bacterial membranes catalyzing the formation of pentacyclic sterol-like triterpenes, was studied by using different classes of compounds originally developed as inhibitors of oxidosqualene cyclase (OSC) (E.C.	Triterpenes	96-107	lanosterol synthase	Homo sapiens	199-220
10549876-1	1999	Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3).	Triterpenes	220-230	nitric oxide synthase 2, inducible	Mus musculus	124-128
10607427-3	1999	In the present study, a triterpene natural product, correolide, was found to block Kv1.3 channels in human and miniswine T cells by electrophysiological characterization.	Triterpenes	24-34	potassium voltage-gated channel subfamily A member 3	Homo sapiens	83-88
9918566-1	1999	Acetyl-11-keto-beta-boswellic acid (AKBA) is a pentacyclic triterpene that inhibits 5-lipoxygenase in a selective, enzymedirected, nonredox, and noncompetitive manner.	Triterpenes	59-69	arachidonate 5-lipoxygenase	Homo sapiens	84-98
10425145-1	1999	Activity-guided fractionation of a methanol extract of the leaves of Ilex kudincha led to the isolation of seven acyl CoA cholesteryl acyl transferase (ACAT) inhibitory triterpenes.	Triterpenes	169-180	carboxylesterase 1	Homo sapiens	113-150
10425145-1	1999	Activity-guided fractionation of a methanol extract of the leaves of Ilex kudincha led to the isolation of seven acyl CoA cholesteryl acyl transferase (ACAT) inhibitory triterpenes.	Triterpenes	169-180	carboxylesterase 1	Homo sapiens	152-156
23194864-2	1996	The pentacyclic triterpene ring is crucial for binding to the enzyme, whereas functional groups (11-keto function in addition to a hydrophilic group on C 4 of ring A) are essential for the 5-lipoxygenase activity.	Triterpenes	16-26	arachidonate 5-lipoxygenase	Homo sapiens	189-203
9343174-1	1997	A triterpene derived from betulinic acid (RPR103611) blocks human immunodeficiency virus type 1 (HIV-1) infection and fusion of CD4+ cells with cells expressing HIV-1 envelope proteins (gp120 and gp41), suggesting an effect on virus entry.	Triterpenes	2-12	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	186-191
9103531-4	1997	The data show that the dual inhibition of 5-lipoxygenase and HLE is unique to boswellic acids: other pentacyclic triterpenes with HLE inhibitory activities (e.g., ursolic acid and amyrin) do not inhibit 5-lipoxygenase, and leukotriene biosynthesis inhibitors from different chemical classes (e.g., NDGA, MK-886 and ZM-230,487) do not impair HLE activity.	Triterpenes	113-124	arachidonate 5-lipoxygenase	Homo sapiens	42-56
9103531-4	1997	The data show that the dual inhibition of 5-lipoxygenase and HLE is unique to boswellic acids: other pentacyclic triterpenes with HLE inhibitory activities (e.g., ursolic acid and amyrin) do not inhibit 5-lipoxygenase, and leukotriene biosynthesis inhibitors from different chemical classes (e.g., NDGA, MK-886 and ZM-230,487) do not impair HLE activity.	Triterpenes	113-124	elastase, neutrophil expressed	Homo sapiens	61-64
9103531-4	1997	The data show that the dual inhibition of 5-lipoxygenase and HLE is unique to boswellic acids: other pentacyclic triterpenes with HLE inhibitory activities (e.g., ursolic acid and amyrin) do not inhibit 5-lipoxygenase, and leukotriene biosynthesis inhibitors from different chemical classes (e.g., NDGA, MK-886 and ZM-230,487) do not impair HLE activity.	Triterpenes	113-124	elastase, neutrophil expressed	Homo sapiens	130-133
9103531-4	1997	The data show that the dual inhibition of 5-lipoxygenase and HLE is unique to boswellic acids: other pentacyclic triterpenes with HLE inhibitory activities (e.g., ursolic acid and amyrin) do not inhibit 5-lipoxygenase, and leukotriene biosynthesis inhibitors from different chemical classes (e.g., NDGA, MK-886 and ZM-230,487) do not impair HLE activity.	Triterpenes	113-124	elastase, neutrophil expressed	Homo sapiens	130-133
9834145-0	1998	Isolation of translactone-containing triterpenes with thrombin inhibitory activities from the leaves of Lantana camara.	Triterpenes	37-48	coagulation factor II, thrombin	Homo sapiens	54-62
9810272-1	1998	The triterpene betulinic acid inhibits the activity of aminopeptidase N (EC 3.4.11.2) in a dose-dependent manner.	Triterpenes	4-14	alanyl aminopeptidase, membrane	Homo sapiens	55-71
9760176-1	1998	AKBA (acetyl-11-keto-beta-boswellic acid), a natural pentacyclic triterpene, is an orally active leukotriene-synthesis inhibitor, which acts by a 5-lipoxygenase-directed, non-redox, non-competitive mechanism.	Triterpenes	65-75	arachidonate 5-lipoxygenase	Homo sapiens	146-160
23194865-4	1996	Previously, we showed that AKBA interacts with the 5-lipoxygenase via a pentacyclic triterpene selective effector site (Safayhi et al., 1995).	Triterpenes	84-94	arachidonate 5-lipoxygenase	Rattus norvegicus	51-65
8830634-1	1995	The influence of the dammarane triterpene glycosides Rb1, Rb2, Rg1 and Rf and their aglycones 20(S) protopanaxatriol and 20(S) protopanaxadiol on fluctuation of the K+ and H+ flows in erythrocytes induced by ionophore A23187 and Ca2+ was studied.	Triterpenes	31-41	RB transcriptional corepressor 1	Homo sapiens	53-56
8646405-13	1996	The results demonstrate that the pentacyclic triterpene ring system is crucial for binding to the highly selective effector site, whereas functional groups (especially the 11-keto function in addition to a hydrophilic group on C4 of ring A) are essential for 5-LOX inhibitory activity.	Triterpenes	45-55	lysyl oxidase	Homo sapiens	261-264
8206128-8	1994	In activating phospholipase A2, triterpenes with two acetoxyl substituents were most effective, whereas the paired isomers with a hydroxyl group at C-15 alpha and an acetoxyl substituent at C-3 failed the activation.	Triterpenes	32-43	phospholipase A2 group IB	Homo sapiens	14-30
7603462-3	1995	The presence of the noninhibitory pentacyclic triterpenes both in intact cells and in the cell-free system caused a concentration-dependent reversal of the 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid, whereas the inhibitory actions of 5-lipoxygenase inhibitors from different chemical classes (MK-886, L-739,010, ZM-230,487, and nordihydroguaiaretic acid) were not modified.	Triterpenes	46-57	arachidonate 5-lipoxygenase	Rattus norvegicus	156-170
7603462-3	1995	The presence of the noninhibitory pentacyclic triterpenes both in intact cells and in the cell-free system caused a concentration-dependent reversal of the 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid, whereas the inhibitory actions of 5-lipoxygenase inhibitors from different chemical classes (MK-886, L-739,010, ZM-230,487, and nordihydroguaiaretic acid) were not modified.	Triterpenes	46-57	arachidonate 5-lipoxygenase	Rattus norvegicus	255-269
7603462-5	1995	Therefore, we conclude that acetyl-11-keto-beta-boswellic acid acts directly on the 5-lipoxygenase enzyme at a selective site for pentacyclic triterpenes that is different from the arachidonate substrate binding site.	Triterpenes	142-153	arachidonate 5-lipoxygenase	Rattus norvegicus	84-98
1797948-1	1991	Rabbit and human tissues contain substantial amounts of an unusual lipid, a fatty acid ester of a pentacyclic triterpene, that is a potent in vitro inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT).	Triterpenes	110-120	sterol O-acyltransferase 1	Homo sapiens	161-197
1797948-1	1991	Rabbit and human tissues contain substantial amounts of an unusual lipid, a fatty acid ester of a pentacyclic triterpene, that is a potent in vitro inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT).	Triterpenes	110-120	sterol O-acyltransferase 1	Homo sapiens	199-203
1859379-5	1991	The carboxy group at position 28 in the pentacyclic-ring system of the triterpenes contributes to binding to HLE, since replacement of this group with a hydroxy group, as in uvaol, the alcohol analogue of ursolic acid, reduces the potency of inhibition.	Triterpenes	71-82	elastase, neutrophil expressed	Homo sapiens	109-112
1859379-6	1991	The inhibitory potency of ursolic acid is also reduced by addition of 1 M-NaCl, further supporting a postulated electrostatic interaction between the negative charge on the triterpene and a positively charged residue on the enzyme, which we assign to the side chain of Arg-217, located in the vicinity of subsites S4 and S5 in HLE.	Triterpenes	173-183	elastase, neutrophil expressed	Homo sapiens	327-330
33779055-0	2021	Natural triterpenoids isolated from Akebia trifoliata Stem Explants exerts hypoglycemic effect via inhibits alpha-glucosidase and stimulates glucose uptake in insulin-resistance HepG2 cells.	Triterpenes	8-21	sucrase-isomaltase	Homo sapiens	108-125
1898988-5	1991	Similarly, sitosterol and lupane-type triterpene derivatives markedly inhibited this TPA-induced ODC accumulation.	Triterpenes	38-48	ornithine decarboxylase, structural 1	Mus musculus	97-100
2335515-13	1990	Both the negatively charged carboxylic acid group of the triterpene moiety and the esterified fatty acid group were necessary for the ACAT-inhibitory activity of the triterpene ester.	Triterpenes	57-67	sterol O-acyltransferase 1	Oryctolagus cuniculus	134-138
2335515-14	1990	Lastly, we present preliminary data which, together with the structural homology of the rabbit triterpene with known plant compounds, suggest the hypothesis that the triterpene moiety of the rabbit ACAT inhibitor arises from dietary absorption of a plant triterpene.	Triterpenes	95-105	sterol O-acyltransferase 1	Oryctolagus cuniculus	198-202
2335515-14	1990	Lastly, we present preliminary data which, together with the structural homology of the rabbit triterpene with known plant compounds, suggest the hypothesis that the triterpene moiety of the rabbit ACAT inhibitor arises from dietary absorption of a plant triterpene.	Triterpenes	166-176	sterol O-acyltransferase 1	Oryctolagus cuniculus	198-202
2335515-14	1990	Lastly, we present preliminary data which, together with the structural homology of the rabbit triterpene with known plant compounds, suggest the hypothesis that the triterpene moiety of the rabbit ACAT inhibitor arises from dietary absorption of a plant triterpene.	Triterpenes	166-176	sterol O-acyltransferase 1	Oryctolagus cuniculus	198-202
33798849-0	2021	alpha-Glucosidase inhibitory and anti-inflammatory activities of dammarane triterpenoids from the leaves of Cyclocarya paliurus.	Triterpenes	75-88	sucrase isomaltase (alpha-glucosidase)	Mus musculus	0-17
33779055-0	2021	Natural triterpenoids isolated from Akebia trifoliata Stem Explants exerts hypoglycemic effect via inhibits alpha-glucosidase and stimulates glucose uptake in insulin-resistance HepG2 cells.	Triterpenes	8-21	insulin	Homo sapiens	159-166
33779055-3	2021	The results indicated that three triterpenoids exhibited excellent inhibitory activities against alpha-glucosidase.	Triterpenes	33-46	sucrase-isomaltase	Homo sapiens	97-114
33779055-9	2021	These triterpenoids exhibited dual therapeutic effects of alpha-glucosidase inhibition and glucose uptake promotion, thus they could be used as antidiabetic agents for developing novel drugs against type 2 diabetes.	Triterpenes	6-19	sucrase-isomaltase	Homo sapiens	58-75
33812006-1	2021	The pentacyclic triterpenoid quinone methide celastrol (CS) from Tripterygium wilfordii Hook.	Triterpenes	16-28	citrate synthase	Homo sapiens	56-58
33761574-5	2021	The pharmacological effects of pentacyclic triterpenoids are often mediated through the modulation of signalling pathways, including nuclear factor erythroid-2 related factor 2, high-mobility group box protein 1, 11beta-hydroxysteroid dehydrogenase type 1, and Src homology region 2 domain-containing phosphatase-1.	Triterpenes	43-56	NFE2 like bZIP transcription factor 2	Homo sapiens	133-176
33769499-0	2021	Triterpenoid compound betulin attenuates allergic airway inflammation by modulating antioxidants, inflammatory cytokines and tissue transglutaminase in ovalbumin-induced asthma mice model.	Triterpenes	0-12	transglutaminase 2, C polypeptide	Mus musculus	125-148
33769499-0	2021	Triterpenoid compound betulin attenuates allergic airway inflammation by modulating antioxidants, inflammatory cytokines and tissue transglutaminase in ovalbumin-induced asthma mice model.	Triterpenes	0-12	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	152-161
33769499-1	2021	OBJECTIVES: This study hypothesized that to analyse the anti-inflammatory effect of triterpenoid compound betulin in ovalbumin (OVA)-induced asthmatic mice.	Triterpenes	84-96	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	117-126
33769499-1	2021	OBJECTIVES: This study hypothesized that to analyse the anti-inflammatory effect of triterpenoid compound betulin in ovalbumin (OVA)-induced asthmatic mice.	Triterpenes	84-96	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	128-131
34688014-4	2022	Herein, based on the structure of ursolic acid (UA), a total of 53 pentacyclic triterpene derivatives were designed and synthesized as SENP1 inhibitors.	Triterpenes	79-89	SUMO specific peptidase 1	Homo sapiens	135-140
33233650-0	2020	Mitocanic Di- and Triterpenoid Rhodamine B Conjugates.	Triterpenes	18-30	ras homolog family member B	Homo sapiens	31-42
33233650-2	2020	So far, several triterpenoid rhodamine B conjugates have been prepared and screened for their cytotoxic activity.	Triterpenes	16-28	ras homolog family member B	Homo sapiens	29-40
33808384-0	2021	Molecular Docking and Molecular Dynamics Simulation Studies of Triterpenes from Vernonia patula with the Cannabinoid Type 1 Receptor.	Triterpenes	63-74	cannabinoid receptor 1	Homo sapiens	105-132
33808384-1	2021	A molecular docking approach was employed to evaluate the binding affinity of six triterpenes, namely epifriedelanol, friedelin, alpha-amyrin, alpha-amyrin acetate, beta-amyrin acetate, and bauerenyl acetate, towards the cannabinoid type 1 receptor (CB1).	Triterpenes	82-93	cannabinoid receptor 1	Homo sapiens	221-248
33808384-1	2021	A molecular docking approach was employed to evaluate the binding affinity of six triterpenes, namely epifriedelanol, friedelin, alpha-amyrin, alpha-amyrin acetate, beta-amyrin acetate, and bauerenyl acetate, towards the cannabinoid type 1 receptor (CB1).	Triterpenes	82-93	cannabinoid receptor 1	Homo sapiens	250-253
33763472-3	2021	CDDO (2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid), a synthetic triterpenoid, is an Nrf2 activator used to inhibit proliferation and induce differentiation and apoptosis in various cancer cells.	Triterpenes	65-77	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
34800877-2	2021	The pentacyclic triterpenes (PTs) are considered to be the natural inhibitors against HMGB1-related inflammation.	Triterpenes	16-27	high mobility group box 1	Mus musculus	86-91
34973981-6	2022	Moreover, the interaction of the two triterpenoids with hIAPP displayed a spontaneous and exothermic process.	Triterpenes	37-50	islet amyloid polypeptide	Homo sapiens	56-61
34800877-0	2021	Microbial transformation of pentacyclic triterpenes for anti-inflammatory agents on the HMGB1 stimulated RAW 264.7 cells by Streptomyces olivaceus CICC 23628.	Triterpenes	40-51	high mobility group box 1	Mus musculus	88-93
34798773-1	2021	Ganoderic acid A (GAA) is a kind of lanostane-type triterpenoid isolated from Ganoderma lucidum.	Triterpenes	51-63	glucosidase, alpha, acid	Mus musculus	18-21
34182369-5	2021	A combination of sensorial, cell-based and computational analysis revealed distinct structural features, such as spatial arrangement of functional groups in the triterpenoid E-ring, driving to different taste sensations and sweet receptor hTAS1R2/R3 stimulation.	Triterpenes	161-173	taste 1 receptor member 2	Homo sapiens	239-246
34030574-0	2021	Inhibition of catechol-O-methyltransferase by natural pentacyclic triterpenes: structure-activity relationships and kinetic mechanism.	Triterpenes	66-77	catechol-O-methyltransferase	Homo sapiens	14-42
33307873-0	2021	Dammarane triterpenes targeting alpha-synuclein: biological activity and evaluation of binding sites by molecular docking.	Triterpenes	10-21	synuclein alpha	Homo sapiens	32-47
34030574-2	2021	Here, we report the first natural pentacyclic triterpenoid-type COMT inhibitors and their structure-activity relationships and inhibition mechanism.	Triterpenes	46-58	catechol-O-methyltransferase	Homo sapiens	64-68
34833955-6	2021	In this study, a series of phytobioactives were screened based on their chemical classes such as coumarins, flavonoids, and triterpenoids for their action on NQO1.	Triterpenes	124-137	NAD(P)H quinone dehydrogenase 1	Homo sapiens	158-162
34739636-2	2022	Ganoderic Acid A (GAA), one of triterpenoid extracts of Ganoderma lucidum (G. lucidum), has been reported to possess anti-inflammatory effect.	Triterpenes	31-43	alpha glucosidase	Homo sapiens	18-21
34754093-3	2021	In the present study, we identified a synthetic triterpenoid CDDO-Im(1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole) as an activator of Nrf2 (nuclear factor erythroid 2-related factor 2) that displayed strong anti-OA effects.	Triterpenes	48-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	148-152
34754093-3	2021	In the present study, we identified a synthetic triterpenoid CDDO-Im(1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole) as an activator of Nrf2 (nuclear factor erythroid 2-related factor 2) that displayed strong anti-OA effects.	Triterpenes	48-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	154-197
34833905-0	2021	Novel Triterpenoids from Cassia fistula Stem Bark Depreciates STZ-Induced Detrimental Changes in IRS-1/Akt-Mediated Insulin Signaling Mechanisms in Type-1 Diabetic Rats.	Triterpenes	6-19	insulin receptor substrate 1	Rattus norvegicus	97-102
34833905-0	2021	Novel Triterpenoids from Cassia fistula Stem Bark Depreciates STZ-Induced Detrimental Changes in IRS-1/Akt-Mediated Insulin Signaling Mechanisms in Type-1 Diabetic Rats.	Triterpenes	6-19	AKT serine/threonine kinase 1	Rattus norvegicus	103-106
34520797-6	2021	While three other triterpenoid compounds aglinin C 3- acetate (1), aglinin C (2), and 24-epi-cabraleadiol (4) presented the most significant inhibitory effect against TNF-alpha induced NF-kappaB activation in HepG2 cell line in a dose-dependent manner with IC50 values of 12.45 +- 2.37, 23.32 +- 3.25, and 13.95 +- 1.57 muM, respectively.	Triterpenes	18-30	tumor necrosis factor	Homo sapiens	167-176
34569253-6	2021	We found that alisol B 23-acetate (ABA), a major active triterpenoid extracted from Alismatis Rhizoma, a well-known traditional Chinese medicine, can activate renal FXR and induce FXR downstream gene expression in mouse kidney.	Triterpenes	56-68	nuclear receptor subfamily 1, group H, member 4	Mus musculus	165-168
34569253-6	2021	We found that alisol B 23-acetate (ABA), a major active triterpenoid extracted from Alismatis Rhizoma, a well-known traditional Chinese medicine, can activate renal FXR and induce FXR downstream gene expression in mouse kidney.	Triterpenes	56-68	nuclear receptor subfamily 1, group H, member 4	Mus musculus	180-183
34520797-6	2021	While three other triterpenoid compounds aglinin C 3- acetate (1), aglinin C (2), and 24-epi-cabraleadiol (4) presented the most significant inhibitory effect against TNF-alpha induced NF-kappaB activation in HepG2 cell line in a dose-dependent manner with IC50 values of 12.45 +- 2.37, 23.32 +- 3.25, and 13.95 +- 1.57 muM, respectively.	Triterpenes	18-30	nuclear factor kappa B subunit 1	Homo sapiens	185-194
34771010-0	2021	Iridal-Type Triterpenoids Displaying Human Neutrophil Elastase Inhibition and Anti-Inflammatory Effects from Belamcanda chinensis.	Triterpenes	12-25	elastase, neutrophil expressed	Homo sapiens	43-62
34516973-0	2021	Triterpenoids with modified A-ring as modulators of P-gp-dependent drug-resistance in cancer cells.	Triterpenes	0-13	ATP binding cassette subfamily B member 1	Homo sapiens	52-56
34776948-1	2021	Saikosaponin A (SSA), a main triterpenoid saponin component from Radix Bupleurum, has been revealed to have a variety of pharmacological activities.	Triterpenes	29-41	tripartite motif containing 21	Homo sapiens	0-14
34776948-1	2021	Saikosaponin A (SSA), a main triterpenoid saponin component from Radix Bupleurum, has been revealed to have a variety of pharmacological activities.	Triterpenes	29-41	tripartite motif containing 21	Homo sapiens	16-19
34720529-5	2021	Several studies show that drugs targeting Sp downregulation or NR4A1 antagonists are highly effective inhibitors of Sp/NR4A1-regulated pathways and genes in pancreatic and other cancer cells, and the triterpenoid celastrol is a novel dual-acting agent that targets both Sp TFs and NR4A1.	Triterpenes	200-212	nuclear receptor subfamily 4 group A member 1	Homo sapiens	281-286
34516973-5	2021	The docking of triterpenoids 1 and 2 into the drug binding site of P-gp revealed a similarity between the conformation of the tested triterpenoids and that of classical inhibitor verapamil, thus assuming these compounds to be more likely the inhibitors than the substrates of P-gp.	Triterpenes	15-28	ATP binding cassette subfamily B member 1	Homo sapiens	67-71
34516973-5	2021	The docking of triterpenoids 1 and 2 into the drug binding site of P-gp revealed a similarity between the conformation of the tested triterpenoids and that of classical inhibitor verapamil, thus assuming these compounds to be more likely the inhibitors than the substrates of P-gp.	Triterpenes	15-28	ATP binding cassette subfamily B member 1	Homo sapiens	276-280
34516973-5	2021	The docking of triterpenoids 1 and 2 into the drug binding site of P-gp revealed a similarity between the conformation of the tested triterpenoids and that of classical inhibitor verapamil, thus assuming these compounds to be more likely the inhibitors than the substrates of P-gp.	Triterpenes	133-146	ATP binding cassette subfamily B member 1	Homo sapiens	67-71
34516973-5	2021	The docking of triterpenoids 1 and 2 into the drug binding site of P-gp revealed a similarity between the conformation of the tested triterpenoids and that of classical inhibitor verapamil, thus assuming these compounds to be more likely the inhibitors than the substrates of P-gp.	Triterpenes	133-146	ATP binding cassette subfamily B member 1	Homo sapiens	276-280
34681605-0	2021	EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy.	Triterpenes	26-36	epidermal growth factor receptor	Homo sapiens	0-4
34573098-3	2021	Bardoxolone methyl (methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate; CDDO-Me; RTA 402) is a semisynthetic triterpenoid with effects against antioxidative stress and inflammation in neurodegeneration and kidney disease that activates the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway.	Triterpenes	111-123	NFE2 like bZIP transcription factor 2	Homo sapiens	242-285
34573098-3	2021	Bardoxolone methyl (methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate; CDDO-Me; RTA 402) is a semisynthetic triterpenoid with effects against antioxidative stress and inflammation in neurodegeneration and kidney disease that activates the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway.	Triterpenes	111-123	NFE2 like bZIP transcription factor 2	Homo sapiens	287-291
34118223-7	2021	This triterpene may act solely via the activation and translocation of GLUT4 (rather than via nuclear actions, such as upregulation of GLUT4 synthesis), since THO did not alter the amount of GLUT4 mRNA or the content of GLUT4.	Triterpenes	5-15	solute carrier family 2 member 4	Rattus norvegicus	71-76
34118223-7	2021	This triterpene may act solely via the activation and translocation of GLUT4 (rather than via nuclear actions, such as upregulation of GLUT4 synthesis), since THO did not alter the amount of GLUT4 mRNA or the content of GLUT4.	Triterpenes	5-15	solute carrier family 2 member 4	Rattus norvegicus	135-140
34118223-8	2021	Consistent with these data, the stimulatory effect of this triterpene on the quantity of GLUT4 in the membrane fraction was dependent upon p38 phosphorylation.	Triterpenes	59-69	solute carrier family 2 member 4	Rattus norvegicus	89-94
34118223-8	2021	Consistent with these data, the stimulatory effect of this triterpene on the quantity of GLUT4 in the membrane fraction was dependent upon p38 phosphorylation.	Triterpenes	59-69	mitogen activated protein kinase 14	Rattus norvegicus	139-142
34231603-2	2021	The aim of this study was to investigate the protective effect of a triterpenoid-enriched extract (TEE) from bitter melon leaves against carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice.	Triterpenes	68-80	chemokine (C-C motif) ligand 4	Mus musculus	159-163
34237666-3	2021	Limonoids are a class of triterpenoids known to prevent the release of IL-6, IL-15, IL-1alpha, IL-1beta via TNF and are also known to modulate PI3K/Akt/GSK-3beta, JNK1/2, MAPKp38, ERK1/2, and PI3K/Akt/mTOR signaling pathways and could help to avoid viral infection, persistence, and pathogenesis.	Triterpenes	25-38	interleukin 6	Homo sapiens	71-75
34237666-3	2021	Limonoids are a class of triterpenoids known to prevent the release of IL-6, IL-15, IL-1alpha, IL-1beta via TNF and are also known to modulate PI3K/Akt/GSK-3beta, JNK1/2, MAPKp38, ERK1/2, and PI3K/Akt/mTOR signaling pathways and could help to avoid viral infection, persistence, and pathogenesis.	Triterpenes	25-38	interleukin 15	Homo sapiens	77-82
34237666-3	2021	Limonoids are a class of triterpenoids known to prevent the release of IL-6, IL-15, IL-1alpha, IL-1beta via TNF and are also known to modulate PI3K/Akt/GSK-3beta, JNK1/2, MAPKp38, ERK1/2, and PI3K/Akt/mTOR signaling pathways and could help to avoid viral infection, persistence, and pathogenesis.	Triterpenes	25-38	interleukin 1 alpha	Homo sapiens	84-93
34237666-3	2021	Limonoids are a class of triterpenoids known to prevent the release of IL-6, IL-15, IL-1alpha, IL-1beta via TNF and are also known to modulate PI3K/Akt/GSK-3beta, JNK1/2, MAPKp38, ERK1/2, and PI3K/Akt/mTOR signaling pathways and could help to avoid viral infection, persistence, and pathogenesis.	Triterpenes	25-38	interleukin 1 alpha	Homo sapiens	95-103
34237666-3	2021	Limonoids are a class of triterpenoids known to prevent the release of IL-6, IL-15, IL-1alpha, IL-1beta via TNF and are also known to modulate PI3K/Akt/GSK-3beta, JNK1/2, MAPKp38, ERK1/2, and PI3K/Akt/mTOR signaling pathways and could help to avoid viral infection, persistence, and pathogenesis.	Triterpenes	25-38	tumor necrosis factor	Homo sapiens	108-111
34116362-7	2021	The in silico analyses of docking score and binding energies, along with predicted pharmacokinetic profiles, indicate that these triterpenoids might have potential as inhibitors of SARS-CoV-2 Mpro, recommending further in vitro and in vivo investigations for a complete understanding and confirmation of their inhibitory potential.	Triterpenes	129-142	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	192-196
34581089-10	2021	These aforementioned results suggest that the total triterpenoids from C. speciosa have significant protective effects against CAG induced by Hp, and its mechanism may be related to enhancing the function of endogenous antioxidant system, suppressing the oxidative stress and inflammatory reaction induced by Hp, correcting lysosomal dysfunction and inflammatory activation of TLR4/NF-kappaB/NLRP3 inflammasome signaling pathway and thus inhibiting mitochondria-mediated apoptosis.	Triterpenes	52-65	toll-like receptor 4	Mus musculus	377-381
34581089-10	2021	These aforementioned results suggest that the total triterpenoids from C. speciosa have significant protective effects against CAG induced by Hp, and its mechanism may be related to enhancing the function of endogenous antioxidant system, suppressing the oxidative stress and inflammatory reaction induced by Hp, correcting lysosomal dysfunction and inflammatory activation of TLR4/NF-kappaB/NLRP3 inflammasome signaling pathway and thus inhibiting mitochondria-mediated apoptosis.	Triterpenes	52-65	NLR family, pyrin domain containing 3	Mus musculus	392-397
34436980-4	2021	In this study, the triterpene 3beta-6beta-16beta-trihydroxilup-20 (29)-ene (CLF-1) was isolated from Combretum leprosum, and its molecular structure was determined by NMR and infrared spectroscopy.	Triterpenes	19-29	cytokine receptor like factor 1	Homo sapiens	76-81
34371964-0	2021	Promising Anticancer Activities of Alismatis rhizome and Its Triterpenes via p38 and PI3K/Akt/mTOR Signaling Pathways.	Triterpenes	61-72	mitogen-activated protein kinase 14	Homo sapiens	77-80
34371964-0	2021	Promising Anticancer Activities of Alismatis rhizome and Its Triterpenes via p38 and PI3K/Akt/mTOR Signaling Pathways.	Triterpenes	61-72	AKT serine/threonine kinase 1	Homo sapiens	90-93
34371964-0	2021	Promising Anticancer Activities of Alismatis rhizome and Its Triterpenes via p38 and PI3K/Akt/mTOR Signaling Pathways.	Triterpenes	61-72	mechanistic target of rapamycin kinase	Homo sapiens	94-98
34371964-7	2021	Several beneficial functions of triterpenoids found in AR might be due to p38 activation and inhibition of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways.	Triterpenes	32-45	mitogen-activated protein kinase 14	Homo sapiens	74-77
34371964-7	2021	Several beneficial functions of triterpenoids found in AR might be due to p38 activation and inhibition of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways.	Triterpenes	32-45	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	111-140
34371964-7	2021	Several beneficial functions of triterpenoids found in AR might be due to p38 activation and inhibition of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways.	Triterpenes	32-45	protein tyrosine kinase 2 beta	Homo sapiens	148-164
34371964-7	2021	Several beneficial functions of triterpenoids found in AR might be due to p38 activation and inhibition of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways.	Triterpenes	32-45	AKT serine/threonine kinase 1	Homo sapiens	166-169
34481532-5	2021	In this study, we performed a cell-based screening method for discovering miR-122 activators and found that oleanolic acid (OA), a natural pentacyclic triterpene, specifically increased miR-122 expression in a concentration-dependent manner.	Triterpenes	151-161	microRNA 122	Homo sapiens	74-81
34481532-5	2021	In this study, we performed a cell-based screening method for discovering miR-122 activators and found that oleanolic acid (OA), a natural pentacyclic triterpene, specifically increased miR-122 expression in a concentration-dependent manner.	Triterpenes	151-161	microRNA 122	Homo sapiens	186-193
34129861-2	2021	While a hybrid holding a piperazinyl spacer at C-28 proved to be cytotoxic in the nano-molar concentration range, hybrids with a direct linkage of the Rho B residue to C-3 of the triterpenoid skeleton are cytotoxic only in the low micro-molar concentration range without any selectivity.	Triterpenes	179-191	ras homolog family member B	Homo sapiens	151-156
34371964-7	2021	Several beneficial functions of triterpenoids found in AR might be due to p38 activation and inhibition of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways.	Triterpenes	32-45	mechanistic target of rapamycin kinase	Homo sapiens	171-200
34371964-7	2021	Several beneficial functions of triterpenoids found in AR might be due to p38 activation and inhibition of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways.	Triterpenes	32-45	mechanistic target of rapamycin kinase	Homo sapiens	202-206
34111615-0	2021	The triterpenoid ursolic acid ameliorates stress in Caenorhabditis elegans by affecting the depression-associated genes skn-1 and prdx2.	Triterpenes	4-16	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	120-125
34111615-0	2021	The triterpenoid ursolic acid ameliorates stress in Caenorhabditis elegans by affecting the depression-associated genes skn-1 and prdx2.	Triterpenes	4-16	Peroxiredoxin prdx-2	Caenorhabditis elegans	130-135
34108504-3	2021	However, nine dietary scaffolds, such as silibinin, flavopiridol, oleandrin, ursolic acid, alpha-boswellic acid, beta-boswellic acid, triterpenoid, guggulsterone, and oleanolic acid potentially bound to the cavity of PI3K-alpha, PKC-eta, H-Ras, and Ras with the highest binding energy.	Triterpenes	134-146	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	217-227
34345605-3	2021	Triterpenoids from C. asiatica could act as inhibitors of S-CoV-2 Mpro.	Triterpenes	0-13	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	66-70
34108504-3	2021	However, nine dietary scaffolds, such as silibinin, flavopiridol, oleandrin, ursolic acid, alpha-boswellic acid, beta-boswellic acid, triterpenoid, guggulsterone, and oleanolic acid potentially bound to the cavity of PI3K-alpha, PKC-eta, H-Ras, and Ras with the highest binding energy.	Triterpenes	134-146	HRas proto-oncogene, GTPase	Homo sapiens	238-243
35562091-12	2022	The molecular docking models predicted that olean-type triterpenes in COE may contribute most to therapeutic effects of rheumatoid arthritis through targeting TNF-alpha.	Triterpenes	55-66	tumor necrosis factor	Rattus norvegicus	159-168
34072312-6	2021	Moreover, triterpenoids containing a lactone ring and/or quinone-like substructures, e.g., bruceantin, whitaferin A, withanolide F, celastrol, and pristimerin, displayed remarkable activity, with the latter two compounds acting as inhibitors of both NF-kappaB and proteasome chymotrypsin-like activity.	Triterpenes	10-23	nuclear factor kappa B subunit 1	Homo sapiens	250-259
35489273-0	2022	Structurally diverse mono-/dimeric triterpenoids from the vulnerable conifer Pseudotsuga gaussenii and their PTP1B inhibitory effects.	Triterpenes	35-48	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	109-114
35323502-1	2022	Through activity-guided fractionation, a new triterpene (asperflagin, 1) was isolated as a PPAR-gamma agonist from the jellyfish-derived fungus Aspergillus flavus.	Triterpenes	45-55	peroxisome proliferator activated receptor gamma	Homo sapiens	91-101
35543349-3	2022	The object of this study was to investigate the hepatoprotective effects of ganoderic acid A (GAA, one of the main triterpenoids in G. lucidum) against alcohol-induced liver injury and reveal the underlying mechanisms of its protective effects.	Triterpenes	115-128	glucosidase, alpha, acid	Mus musculus	94-97
35600856-1	2022	Ginsenoside Rh2 (G-Rh2), a rare protopanaxadiol (PPD)-type triterpene saponin, from Panax ginseng has anti-proliferation, anti-invasion, and anti-metastatic activity.	Triterpenes	59-69	Rh associated glycoprotein	Homo sapiens	12-15
34989452-3	2022	Phytochemical studies carried out on species of the Combretum genus demonstrated the presence of several classes of bioactive chemical compounds, including the triterpene 3beta,6beta,16beta-trihydroxilup-20(29)-ene (CLF-1).	Triterpenes	160-170	cytokine receptor like factor 1	Homo sapiens	216-221
34989452-4	2022	In this perspective, the objective of this review was to gather all pharmacological activities attributed to the CLF-1 triterpene, highlighting its importance for the pharmaceutical industry.	Triterpenes	119-129	cytokine receptor like factor 1	Homo sapiens	113-118
35630550-0	2022	Bioactive Evaluation of Ursane-Type Pentacyclic Triterpenoids: beta-Boswellic Acid Interferes with the Glycosylation and Transport of Intercellular Adhesion Molecule-1 in Human Lung Adenocarcinoma A549 Cells.	Triterpenes	48-61	intercellular adhesion molecule 1	Homo sapiens	134-167
35630550-5	2022	We revealed that the inhibitory activities of ursane-type pentacyclic triterpenoids on the cell surface expression and glycosylation of ICAM-1 and alpha-glucosidase activity were influenced by the number of hydroxy groups and/or the presence and position of a carboxyl group.	Triterpenes	70-83	intercellular adhesion molecule 1	Homo sapiens	136-142
35630550-5	2022	We revealed that the inhibitory activities of ursane-type pentacyclic triterpenoids on the cell surface expression and glycosylation of ICAM-1 and alpha-glucosidase activity were influenced by the number of hydroxy groups and/or the presence and position of a carboxyl group.	Triterpenes	70-83	sucrase-isomaltase	Homo sapiens	147-164
35456042-6	2022	Exposure of worms to triterpenoid CDDO-Me, an inhibitor of human LonP1, stimulated only UPRcyt responses.	Triterpenes	21-33	lon peptidase 1, mitochondrial	Homo sapiens	65-70
35458714-2	2022	In the present study, we reported the binding interaction of betulinic acid (BA), a pentacyclic triterpene widely distributed in nature, on alpha-glucosidase and its alleviation on postprandial hyperglycemia.	Triterpenes	96-106	sucrase isomaltase (alpha-glucosidase)	Mus musculus	140-157
35208972-8	2022	The preliminary structure-activity relationship analysis indicated that the gamma-lactone ring at C-22 and C-29, and the olefinic bond at C-12 and C-13 were structurally required for the cytotoxicity of polyhydroxylated oleanane triterpenoids against these four cell lines.	Triterpenes	229-242	homeobox C13	Homo sapiens	147-151
35205173-2	2022	There are research interests in recent years on terpene-derived metabolites (diterpenes, triterpenes and sesquiterpenes), which are believed to serve as excellent cholinesterase inhibitors.	Triterpenes	89-100	butyrylcholinesterase	Homo sapiens	163-177