PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3553170-5 1986 The Golgi fraction was characterized by the presence of the mature 56 kDa alpha 1-protease inhibitor, which was indistinguishable from the serum alpha 1-protease inhibitor in SDS-polyacrylamide gel electrophoresis. polyacrylamide 179-193 serpin family A member 1 Rattus norvegicus 74-100 27433286-9 2016 We found that two mediators of metabolic reprogramming, inflammation, and cell proliferation c-Myc and C/EBPbeta may serve as regulators of polyamine metabolism genes (SMOX, AZIN1, MTAP, SRM, ODC1, AMD1, and AGMAT) as they are overexpressed in tumors, have binding site according to ENCODE ChIP-Seq data, and demonstrate strong coexpression with their targets. Polyamines 140-149 spermine oxidase Homo sapiens 168-172 27692178-1 2016 The extracellular calcium-sensing receptor (CaSR) is a unique G protein-coupled receptor (GPCR) activated by extracellular Ca2+ and by other physiological cations including Mg2+, amino acids, and polyamines. Polyamines 196-206 calcium sensing receptor Homo sapiens 18-42 27692178-1 2016 The extracellular calcium-sensing receptor (CaSR) is a unique G protein-coupled receptor (GPCR) activated by extracellular Ca2+ and by other physiological cations including Mg2+, amino acids, and polyamines. Polyamines 196-206 calcium sensing receptor Homo sapiens 44-48 26082265-8 2016 Physiological, biochemical and transcriptomic analyses showed that SlDREB2 enhanced plant tolerance to salinity by improvement of K(+) /Na(+) ratio, and proline and polyamines biosynthesis. Polyamines 165-175 dehydration responsive element binding protein Solanum lycopersicum 67-74 27165407-3 2016 Wasp venoms are also a rich source of therapeutically important toxins which includes short cationic peptides, kinins, polyamines and polyDNA viruses, to name a few indentified. Polyamines 119-129 WASP actin nucleation promoting factor Homo sapiens 0-4 26709005-5 2016 These findings suggest that pharmacologic CaSR activators and CaSR-based nutrients such as calcium, polyamines, phenylalanine, tryptophan, and oligo-peptides might be useful in conditioning the gut microenvironment, and thus, in the prevention and treatment of disorders such as inflammatory bowel disease (IBD), infectious enterocolitis, and other inflammatory and secretory diarrheal diseases. Polyamines 100-110 calcium-sensing receptor Mus musculus 42-46 26709005-5 2016 These findings suggest that pharmacologic CaSR activators and CaSR-based nutrients such as calcium, polyamines, phenylalanine, tryptophan, and oligo-peptides might be useful in conditioning the gut microenvironment, and thus, in the prevention and treatment of disorders such as inflammatory bowel disease (IBD), infectious enterocolitis, and other inflammatory and secretory diarrheal diseases. Polyamines 100-110 calcium-sensing receptor Mus musculus 62-66 26658868-5 2015 We find that, in contrast, GSG1L, a transmembrane auxiliary protein identified recently as being part of the AMPAR proteome, acts to reduce the weighted mean single-channel conductance and calcium permeability of recombinant CP-AMPARs, while increasing polyamine-dependent rectification. Polyamines 253-262 GSG1-like Rattus norvegicus 27-32 26277788-3 2016 In this study, specific silencing of the expression of three genes of PA biosynthesis pathway, ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (SAMDC), and spermidine synthase (SPDSYN) was achieved using RNA interference in MCF 7 breast cancer cell line. Polyamines 70-72 spermidine synthase Homo sapiens 174-193 26658868-13 2015 We now report that the recently identified auxiliary protein GSG1L decreases weighted mean channel conductance and calcium permeability of CP-AMPARs while increasing polyamine-dependent rectification by diminishing outward current. Polyamines 166-175 GSG1-like Rattus norvegicus 61-66 26884982-1 2015 OBJECTIVE: To observe the role of ornithine decarboxylase (ODC)/polyamine pathway in focal cerebral ischemia-reperfusion injury and to explore its mechanism in rats. Polyamines 64-73 ornithine decarboxylase 1 Rattus norvegicus 34-57 26884982-1 2015 OBJECTIVE: To observe the role of ornithine decarboxylase (ODC)/polyamine pathway in focal cerebral ischemia-reperfusion injury and to explore its mechanism in rats. Polyamines 64-73 ornithine decarboxylase 1 Rattus norvegicus 59-62 26884982-11 2015 CONCLUSION: Down-regulation of ODC/polyamine pathway may inhibit CHOP-mediated apoptosis caused by endoplasmic reticulum stress and plays a protective role in cerebral I/R injury. Polyamines 35-44 ornithine decarboxylase 1 Rattus norvegicus 31-34 26884982-11 2015 CONCLUSION: Down-regulation of ODC/polyamine pathway may inhibit CHOP-mediated apoptosis caused by endoplasmic reticulum stress and plays a protective role in cerebral I/R injury. Polyamines 35-44 DNA-damage inducible transcript 3 Rattus norvegicus 65-69 27165407-7 2016 Besides, the other components of wasp venom such as kinins, polyamines and polyDNA viruses show various pharmacological promise in the treatment of pain, inflammatory disease, and neurodegenerative diseases such as epilepsy and aversion. Polyamines 60-70 WASP actin nucleation promoting factor Homo sapiens 33-37 26405039-6 2015 Conversely, a reciprocal mutation in OCT1 (F161L) shifted the polyamine-sensitivity phenotype toward that of OCT3. Polyamines 62-71 solute carrier family 22 member 1 Homo sapiens 37-41 26338723-0 2015 Metal complexes of pyridine-fused macrocyclic polyamines targeting the chemokine receptor CXCR4. Polyamines 46-56 C-X-C motif chemokine receptor 4 Homo sapiens 90-95 26338723-2 2015 Macrocyclic polyamines and their metal complexes are known to exert anti-HIV activity, many acting as HIV entry inhibitors by specifically binding to CXCR4. Polyamines 12-22 C-X-C motif chemokine receptor 4 Homo sapiens 150-155 26338723-4 2015 By evaluating these macrocyclic polyamines and their complexes with Mn(2+), Cu(2+), Fe(3+), and Zn(2+), we have discovered novel CXCR4-binding compounds. Polyamines 32-42 C-X-C motif chemokine receptor 4 Homo sapiens 129-134 26405039-0 2015 Role of a Hydrophobic Pocket in Polyamine Interactions with the Polyspecific Organic Cation Transporter OCT3. Polyamines 32-41 OCTN3 Homo sapiens 104-108 26405039-6 2015 Conversely, a reciprocal mutation in OCT1 (F161L) shifted the polyamine-sensitivity phenotype toward that of OCT3. Polyamines 62-71 OCTN3 Homo sapiens 109-113 26538654-5 2015 Arginase 1 (Arg1) and nitric oxide synthases compete for l-arginine to produce either polyamines or nitric oxide, respectively. Polyamines 86-96 arginase, liver Mus musculus 12-16 26396188-8 2015 Additionally, polyamine depletion resulted in elevation of mRNA and protein levels of the stress-induced C/EBP homologous protein (CHOP), whose dominant negative function is known to inhibit C/EBPbeta DNA binding activity. Polyamines 14-23 DNA damage inducible transcript 3 Homo sapiens 131-135 26396188-6 2015 Polyamine depletion inhibited the second division of the mitotic clonal expansion (MCE), and inhibited the expression of PPARgamma and C/EBPalpha, the master regulators of adipogenesis. Polyamines 0-9 peroxisome proliferator activated receptor gamma Homo sapiens 121-130 26396188-6 2015 Polyamine depletion inhibited the second division of the mitotic clonal expansion (MCE), and inhibited the expression of PPARgamma and C/EBPalpha, the master regulators of adipogenesis. Polyamines 0-9 CCAAT enhancer binding protein alpha Homo sapiens 135-145 26396188-8 2015 Additionally, polyamine depletion resulted in elevation of mRNA and protein levels of the stress-induced C/EBP homologous protein (CHOP), whose dominant negative function is known to inhibit C/EBPbeta DNA binding activity. Polyamines 14-23 DNA damage inducible transcript 3 Homo sapiens 105-129 26396188-8 2015 Additionally, polyamine depletion resulted in elevation of mRNA and protein levels of the stress-induced C/EBP homologous protein (CHOP), whose dominant negative function is known to inhibit C/EBPbeta DNA binding activity. Polyamines 14-23 CCAAT enhancer binding protein beta Homo sapiens 191-200 26396188-9 2015 Conditional knockdown of CHOP in polyamine-depleted preadipocytes restored PPARgamma and C/EBPalpha expression, but failed to recover MCE and differentiation. Polyamines 33-42 DNA damage inducible transcript 3 Homo sapiens 25-29 26396188-9 2015 Conditional knockdown of CHOP in polyamine-depleted preadipocytes restored PPARgamma and C/EBPalpha expression, but failed to recover MCE and differentiation. Polyamines 33-42 peroxisome proliferator activated receptor gamma Homo sapiens 75-84 26396188-9 2015 Conditional knockdown of CHOP in polyamine-depleted preadipocytes restored PPARgamma and C/EBPalpha expression, but failed to recover MCE and differentiation. Polyamines 33-42 CCAAT enhancer binding protein alpha Homo sapiens 89-99 26396188-11 2015 We conclude that de novo synthesis of polyamines during adipogenesis is required for down-regulation of CHOP to allow C/EBPbeta activation, and for promoting MCE. Polyamines 38-48 DNA damage inducible transcript 3 Homo sapiens 104-108 26396188-11 2015 We conclude that de novo synthesis of polyamines during adipogenesis is required for down-regulation of CHOP to allow C/EBPbeta activation, and for promoting MCE. Polyamines 38-48 CCAAT enhancer binding protein beta Homo sapiens 118-127 26456331-4 2015 Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1:CLOCK to conserved DNA elements. Polyamines 95-104 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 146-151 26456331-5 2015 In turn, polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1. Polyamines 9-19 period circadian clock 2 Mus musculus 143-147 26456331-5 2015 In turn, polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1. Polyamines 9-19 cryptochrome 1 (photolyase-like) Mus musculus 152-156 26538654-5 2015 Arginase 1 (Arg1) and nitric oxide synthases compete for l-arginine to produce either polyamines or nitric oxide, respectively. Polyamines 86-96 arginase, liver Mus musculus 0-10 26336927-8 2015 Moreover, ectopic overexpression of WT-RhoA in polyamine-deficient cells rescued the inhibition of Ca(2+) influx and cell migration induced by polyamine depletion. Polyamines 47-56 ras homolog family member A Rattus norvegicus 39-43 25982580-1 2015 BACKGROUND: Diamine oxidase (DAO) is a polyamine-degrading enzyme also implicated in histamine metabolism. Polyamines 39-48 D-amino acid oxidase Homo sapiens 29-32 26336927-8 2015 Moreover, ectopic overexpression of WT-RhoA in polyamine-deficient cells rescued the inhibition of Ca(2+) influx and cell migration induced by polyamine depletion. Polyamines 143-152 ras homolog family member A Rattus norvegicus 39-43 26310141-2 2015 Previously, we have shown that CuAO1 is involved in ABA associated growth responses and ABA- and PA-mediated rapid nitric oxide (NO) production. Polyamines 97-99 Copper amine oxidase family protein Arabidopsis thaliana 31-36 26383232-5 2015 Melatonin treatment reduced macrophage expression of Cat-2b, Cat1, and ArgI, genes involved in arginine uptake and polyamine synthesis. Polyamines 115-124 GIT ArfGAP 1 Homo sapiens 61-65 26604686-2 2015 The drug suppresses the synthesis of proinflammatory enzymes, such as cyclo-oxygenases-1 and -2 (COX-1 and 2), downregulates the production of prostaglandins (PGs) and tromboxanes, and inhibits polyamines production by blocking ornithine decarboxylase induction involved in nonmelanoma skin carcinogenesis. Polyamines 194-204 mitochondrially encoded cytochrome c oxidase I Homo sapiens 97-108 26460945-0 2015 Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth. Polyamines 48-57 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 23-27 26443277-0 2015 Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1. Polyamines 88-97 ornithine decarboxylase 1 Homo sapiens 20-43 26443277-0 2015 Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1. Polyamines 88-97 ornithine decarboxylase antizyme 1 Homo sapiens 105-114 26443277-1 2015 Ornithine decarboxylase (ODC) catalyzes the first and rate-limiting step of polyamine biosynthesis in humans. Polyamines 76-85 ornithine decarboxylase 1 Homo sapiens 0-23 26443277-1 2015 Ornithine decarboxylase (ODC) catalyzes the first and rate-limiting step of polyamine biosynthesis in humans. Polyamines 76-85 ornithine decarboxylase 1 Homo sapiens 25-28 26443277-3 2015 Excessive accumulation of polyamines has a cytotoxic effect on cells and elevated level of ODC activity is associated with cancer development. Polyamines 26-36 ornithine decarboxylase 1 Homo sapiens 91-94 26443277-4 2015 To maintain normal cellular proliferation, regulation of polyamine synthesis is imposed by Antizyme1 (AZ1). Polyamines 57-66 ornithine decarboxylase antizyme 1 Homo sapiens 91-100 26443277-4 2015 To maintain normal cellular proliferation, regulation of polyamine synthesis is imposed by Antizyme1 (AZ1). Polyamines 57-66 ornithine decarboxylase antizyme 1 Homo sapiens 102-105 26443277-5 2015 The expression of AZ1 is induced by a ribosomal frameshifting mechanism in response to increased intracellular polyamines. Polyamines 111-121 ornithine decarboxylase antizyme 1 Homo sapiens 18-21 26443277-6 2015 AZ1 regulates polyamine homeostasis by inactivating ODC activity and enhancing its degradation. Polyamines 14-23 ornithine decarboxylase antizyme 1 Homo sapiens 0-3 26443277-6 2015 AZ1 regulates polyamine homeostasis by inactivating ODC activity and enhancing its degradation. Polyamines 14-23 ornithine decarboxylase 1 Homo sapiens 52-55 26144376-10 2015 Polyamines act to prevent cAMP-mediated Cl(-) hypersecretion in the colon, acting through CaSR to inhibit PKC-mediated [Ca(2+)]i release from intracellular stores. Polyamines 0-10 calcium sensing receptor Homo sapiens 90-94 26460945-2 2015 We show here that Hedgehog promotes polyamine biosynthesis in GCPs by engaging a non-canonical axis leading to the translation of ornithine decarboxylase (ODC). Polyamines 36-45 ornithine decarboxylase 1 Homo sapiens 130-153 26460945-2 2015 We show here that Hedgehog promotes polyamine biosynthesis in GCPs by engaging a non-canonical axis leading to the translation of ornithine decarboxylase (ODC). Polyamines 36-45 ornithine decarboxylase 1 Homo sapiens 155-158 26460945-4 2015 Phosphorylated CNBP increases its association with Sufu, followed by CNBP stabilization, ODC translation, and polyamine biosynthesis. Polyamines 110-119 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 15-19 26585710-6 2015 In contrast, oxidative mitochondrial metabolism and enhanced polyamine production are hallmarks and requirements for IL-4-induced macrophage activation (MIL-4 or M2). Polyamines 61-70 interleukin 4 Homo sapiens 117-121 26186363-11 2015 We observed a time dependent regulation of ADC1 and ADC2 genes, which correlates with polyamine levels. Polyamines 86-95 arginine decarboxylase 1 Arabidopsis thaliana 43-47 26186363-11 2015 We observed a time dependent regulation of ADC1 and ADC2 genes, which correlates with polyamine levels. Polyamines 86-95 arginine decarboxylase 2 Arabidopsis thaliana 52-56 26378511-0 2015 Spectroscopic Study on the Interaction between Naphthalimide-Polyamine Conjugates and Bovine Serum Albumin (BSA). Polyamines 61-70 albumin Homo sapiens 93-106 26426536-4 2015 The rate-limiting enzyme in polyamine biosynthesis is ornithine decarboxylase, which is encoded by the gene Odc1. Polyamines 28-37 ornithine decarboxylase, structural 1 Mus musculus 54-77 26426536-4 2015 The rate-limiting enzyme in polyamine biosynthesis is ornithine decarboxylase, which is encoded by the gene Odc1. Polyamines 28-37 ornithine decarboxylase, structural 1 Mus musculus 108-112 26426536-13 2015 Together these results indicate that Odc1 and polyamines are required for androgens to exert their effect in mediating prostatic bud induction, and are required for the expression of a subset of prostatic developmental regulatory genes including Notch1 and Nkx3.1. Polyamines 46-56 notch 1 Mus musculus 246-252 26426536-13 2015 Together these results indicate that Odc1 and polyamines are required for androgens to exert their effect in mediating prostatic bud induction, and are required for the expression of a subset of prostatic developmental regulatory genes including Notch1 and Nkx3.1. Polyamines 46-56 NK3 homeobox 1 Mus musculus 257-263 26378511-1 2015 The effect of a naphthalimide pharmacophore coupled with diverse substituents on the interaction between naphthalimide-polyamine conjugates 1-4 and bovine serum albumin (BSA) was studied by UV absorption, fluorescence and circular dichroism (CD) spectroscopy under physiological conditions (pH = 7.4). Polyamines 119-128 albumin Homo sapiens 155-168 26305948-2 2015 To maintain polyamine homeostasis, the catalytic activity and protein abundance of ornithine decarboxylase (ODC), the committed enzyme for polyamine biosynthesis, are reciprocally controlled by the regulatory proteins antizyme isoform 1 (Az1) and antizyme inhibitor (AzIN). Polyamines 12-21 ornithine decarboxylase 1 Homo sapiens 83-106 26449415-0 2015 KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Polyamines 27-37 potassium inwardly rectifying channel subfamily J member 15 Homo sapiens 0-6 26449415-0 2015 KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Polyamines 27-37 potassium inwardly rectifying channel subfamily J member 15 Homo sapiens 7-13 26449415-6 2015 Depletion of cytoplasmic polyamines, highly positively charged small molecules that regulate Kir4.2 function, completely inhibits galvanotaxis, whereas increase of intracellular polyamines enhances galvanotaxis in a Kir4.2-dependent manner. Polyamines 25-35 potassium inwardly rectifying channel subfamily J member 15 Homo sapiens 93-99 26449415-6 2015 Depletion of cytoplasmic polyamines, highly positively charged small molecules that regulate Kir4.2 function, completely inhibits galvanotaxis, whereas increase of intracellular polyamines enhances galvanotaxis in a Kir4.2-dependent manner. Polyamines 25-35 potassium inwardly rectifying channel subfamily J member 15 Homo sapiens 216-222 26449415-6 2015 Depletion of cytoplasmic polyamines, highly positively charged small molecules that regulate Kir4.2 function, completely inhibits galvanotaxis, whereas increase of intracellular polyamines enhances galvanotaxis in a Kir4.2-dependent manner. Polyamines 178-188 potassium inwardly rectifying channel subfamily J member 15 Homo sapiens 216-222 26449415-7 2015 Expression of a polyamine-binding defective mutant of KCNJ15 significantly decreases galvanotaxis. Polyamines 16-25 potassium inwardly rectifying channel subfamily J member 15 Homo sapiens 54-60 26449415-9 2015 Taken together these data suggest a previously unknown two-molecule sensing mechanism in which KCNJ15/Kir4.2 couples with polyamines in sensing weak electric fields. Polyamines 122-132 potassium inwardly rectifying channel subfamily J member 15 Homo sapiens 95-101 26449415-9 2015 Taken together these data suggest a previously unknown two-molecule sensing mechanism in which KCNJ15/Kir4.2 couples with polyamines in sensing weak electric fields. Polyamines 122-132 potassium inwardly rectifying channel subfamily J member 15 Homo sapiens 102-108 26002808-8 2015 Human ORC1, ORC2, and SLC25A29 are likely to be involved in the biosynthesis and transport of arginine, which can be used as a precursor for the synthesis of NO, agmatine, polyamines, creatine, glutamine, glutamate, and proline, as well as in the degradation of basic amino acids. Polyamines 172-182 origin recognition complex subunit 1 Homo sapiens 6-10 26002808-8 2015 Human ORC1, ORC2, and SLC25A29 are likely to be involved in the biosynthesis and transport of arginine, which can be used as a precursor for the synthesis of NO, agmatine, polyamines, creatine, glutamine, glutamate, and proline, as well as in the degradation of basic amino acids. Polyamines 172-182 origin recognition complex subunit 2 Homo sapiens 12-16 26002808-8 2015 Human ORC1, ORC2, and SLC25A29 are likely to be involved in the biosynthesis and transport of arginine, which can be used as a precursor for the synthesis of NO, agmatine, polyamines, creatine, glutamine, glutamate, and proline, as well as in the degradation of basic amino acids. Polyamines 172-182 solute carrier family 25 member 29 Homo sapiens 22-30 26002808-10 2015 Ort1p is involved in the biosynthesis of arginine and polyamines in yeast. Polyamines 54-64 Ort1p Saccharomyces cerevisiae S288C 0-5 26093026-1 2015 Tissue polyamine levels are largely determined by the activity of ornithine decarboxylase (ODC, EC 4.1.17), which catalyzes the conversion of ornithine to the diamine putrescine. Polyamines 7-16 ornithine decarboxylase 1 Homo sapiens 66-89 26093026-1 2015 Tissue polyamine levels are largely determined by the activity of ornithine decarboxylase (ODC, EC 4.1.17), which catalyzes the conversion of ornithine to the diamine putrescine. Polyamines 7-16 ornithine decarboxylase 1 Homo sapiens 91-94 26004358-5 2015 Under Cd stress, presoaking seeds in either polyamine significantly increased seedling growth, membrane stability index, relative water content, concentrations of protein, starch, ascorbic acid, total glutathione, Spm and Spd, and the activities of superoxide dismutase and catalase. Polyamines 44-53 catalase-1 Triticum aestivum 274-282 26305948-2 2015 To maintain polyamine homeostasis, the catalytic activity and protein abundance of ornithine decarboxylase (ODC), the committed enzyme for polyamine biosynthesis, are reciprocally controlled by the regulatory proteins antizyme isoform 1 (Az1) and antizyme inhibitor (AzIN). Polyamines 12-21 ornithine decarboxylase 1 Homo sapiens 108-111 26305948-2 2015 To maintain polyamine homeostasis, the catalytic activity and protein abundance of ornithine decarboxylase (ODC), the committed enzyme for polyamine biosynthesis, are reciprocally controlled by the regulatory proteins antizyme isoform 1 (Az1) and antizyme inhibitor (AzIN). Polyamines 139-148 ornithine decarboxylase 1 Homo sapiens 83-106 26305948-2 2015 To maintain polyamine homeostasis, the catalytic activity and protein abundance of ornithine decarboxylase (ODC), the committed enzyme for polyamine biosynthesis, are reciprocally controlled by the regulatory proteins antizyme isoform 1 (Az1) and antizyme inhibitor (AzIN). Polyamines 139-148 ornithine decarboxylase 1 Homo sapiens 108-111 26305948-3 2015 Az1 suppresses polyamine production by inhibiting the assembly of the functional ODC homodimer and, most uniquely, by targeting ODC for ubiquitin-independent proteolytic destruction by the 26S proteasome. Polyamines 15-24 ornithine decarboxylase 1 Homo sapiens 81-84 26305948-4 2015 In contrast, AzIN positively regulates polyamine levels by competing with ODC for Az1 binding. Polyamines 39-48 ornithine decarboxylase 1 Homo sapiens 74-77 26305948-10 2015 Finally, the AzIN-Az1 structure suggests how AzIN may effectively compete with ODC for Az1 to restore polyamine production. Polyamines 102-111 ornithine decarboxylase 1 Homo sapiens 79-82 26086092-3 2015 It was found that polyamines, especially spermidine, can permeate NMDA channels expressed from GluN1/GluN2A or GluN1/GluN2B activated by glycine and glutamate. Polyamines 18-28 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 95-100 26086092-3 2015 It was found that polyamines, especially spermidine, can permeate NMDA channels expressed from GluN1/GluN2A or GluN1/GluN2B activated by glycine and glutamate. Polyamines 18-28 glutamate ionotropic receptor NMDA type subunit 2A Homo sapiens 101-107 26086092-3 2015 It was found that polyamines, especially spermidine, can permeate NMDA channels expressed from GluN1/GluN2A or GluN1/GluN2B activated by glycine and glutamate. Polyamines 18-28 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens 111-116 26086092-3 2015 It was found that polyamines, especially spermidine, can permeate NMDA channels expressed from GluN1/GluN2A or GluN1/GluN2B activated by glycine and glutamate. Polyamines 18-28 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 117-123 26056006-0 2015 Characterization of spermidine synthase and spermine synthase--The polyamine-synthetic enzymes that induce early flowering in Gentiana triflora. Polyamines 67-76 spermidine synthase Arabidopsis thaliana 20-39 26056006-0 2015 Characterization of spermidine synthase and spermine synthase--The polyamine-synthetic enzymes that induce early flowering in Gentiana triflora. Polyamines 67-76 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Arabidopsis thaliana 44-61 26056006-3 2015 Here, we identified homologs of two Arabidopsis polyamine-synthetic enzymes, spermidine synthase (SPDS) and spermine synthase (SPMS) denoted as GtSPDS and GtSPMS, from the gentian plant, Gentiana triflora. Polyamines 48-57 spermidine synthase Arabidopsis thaliana 77-96 26056006-3 2015 Here, we identified homologs of two Arabidopsis polyamine-synthetic enzymes, spermidine synthase (SPDS) and spermine synthase (SPMS) denoted as GtSPDS and GtSPMS, from the gentian plant, Gentiana triflora. Polyamines 48-57 spermidine synthase Arabidopsis thaliana 98-102 26056006-3 2015 Here, we identified homologs of two Arabidopsis polyamine-synthetic enzymes, spermidine synthase (SPDS) and spermine synthase (SPMS) denoted as GtSPDS and GtSPMS, from the gentian plant, Gentiana triflora. Polyamines 48-57 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Arabidopsis thaliana 108-125 26117647-6 2015 Docking of the 45 most spermine-sensitive bisbenzamidines to a recently described acidic interface between the N-terminal domains of GluN1 and GluN2B mediating polyamine stimulation of the NR revealed the domain contributed by GluN1 as the most relevant target. Polyamines 160-169 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 133-138 26117647-6 2015 Docking of the 45 most spermine-sensitive bisbenzamidines to a recently described acidic interface between the N-terminal domains of GluN1 and GluN2B mediating polyamine stimulation of the NR revealed the domain contributed by GluN1 as the most relevant target. Polyamines 160-169 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 143-149 26117647-6 2015 Docking of the 45 most spermine-sensitive bisbenzamidines to a recently described acidic interface between the N-terminal domains of GluN1 and GluN2B mediating polyamine stimulation of the NR revealed the domain contributed by GluN1 as the most relevant target. Polyamines 160-169 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 227-232 25893668-5 2015 We have shown that in cultured human PCa cells, an activation of spermidine/spermine N(1) -acetyl transferase (SSAT; EC 2.3.1.57) enzyme initiates a polyamine oxidation pathway and generates copious amounts of reactive oxygen species in polyamine-rich PCa cells. Polyamines 149-158 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 65-109 25893668-5 2015 We have shown that in cultured human PCa cells, an activation of spermidine/spermine N(1) -acetyl transferase (SSAT; EC 2.3.1.57) enzyme initiates a polyamine oxidation pathway and generates copious amounts of reactive oxygen species in polyamine-rich PCa cells. Polyamines 149-158 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 111-115 25893668-5 2015 We have shown that in cultured human PCa cells, an activation of spermidine/spermine N(1) -acetyl transferase (SSAT; EC 2.3.1.57) enzyme initiates a polyamine oxidation pathway and generates copious amounts of reactive oxygen species in polyamine-rich PCa cells. Polyamines 237-246 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 65-109 25893668-5 2015 We have shown that in cultured human PCa cells, an activation of spermidine/spermine N(1) -acetyl transferase (SSAT; EC 2.3.1.57) enzyme initiates a polyamine oxidation pathway and generates copious amounts of reactive oxygen species in polyamine-rich PCa cells. Polyamines 237-246 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 111-115 26140984-1 2015 Ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis. Polyamines 62-71 ornithine decarboxylase 1 Homo sapiens 0-23 26140984-1 2015 Ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis. Polyamines 62-71 ornithine decarboxylase 1 Homo sapiens 25-28 26032421-1 2015 Degradation of ornithine decarboxylase, the rate-limiting enzyme of polyamine biosynthesis, is promoted by the protein antizyme. Polyamines 68-77 Ornithine decarboxylase Caenorhabditis elegans 15-38 25961839-0 2015 Control of Polyamine Biosynthesis by Antizyme Inhibitor 1 Is Important for Transcriptional Regulation of Arginine Vasopressin in the Male Rat Hypothalamus. Polyamines 11-20 antizyme inhibitor 1 Rattus norvegicus 37-57 25961839-0 2015 Control of Polyamine Biosynthesis by Antizyme Inhibitor 1 Is Important for Transcriptional Regulation of Arginine Vasopressin in the Male Rat Hypothalamus. Polyamines 11-20 arginine vasopressin Rattus norvegicus 114-125 25961839-3 2015 We recently reported increased mRNA expression of antizyme inhibitor 1 (Azin1), an important regulator of polyamine synthesis, in rat SON and PVN as a consequence of 3 days of dehydration. Polyamines 106-115 antizyme inhibitor 1 Rattus norvegicus 50-70 25961839-3 2015 We recently reported increased mRNA expression of antizyme inhibitor 1 (Azin1), an important regulator of polyamine synthesis, in rat SON and PVN as a consequence of 3 days of dehydration. Polyamines 106-115 antizyme inhibitor 1 Rattus norvegicus 72-77 25961839-4 2015 Here we show that AZIN1 protein is highly expressed in both AVP- and oxytocin-positive magnocellular neurons of the SON and PVN together with antizyme 1 (AZ1), ornithine decarboxylase, and polyamines. Polyamines 189-199 antizyme inhibitor 1 Rattus norvegicus 18-23 25961839-11 2015 We have therefore identified AZIN1, and hence by inference, polyamines as novel regulators of the expression of the AVP gene. Polyamines 60-70 arginine vasopressin Rattus norvegicus 116-119 26032421-8 2015 Polyamine-independent induction of antizyme expression was found to be negatively regulated by the peptide transporter PEPT-1, as well as the target of rapamycin, but not by the daf-2 insulin signaling pathway. Polyamines 0-9 Peptide transporter family 1 Caenorhabditis elegans 119-125 26032421-12 2015 This is most likely caused by an increase in antizyme-mediated degradation of ornithine decarboxylase-1 and a resulting reduction in cellular polyamine levels. Polyamines 142-151 Ornithine decarboxylase Caenorhabditis elegans 78-101 25079701-0 2015 Gene polymorphisms in the ornithine decarboxylase-polyamine pathway modify gastric cancer risk by interaction with isoflavone concentrations. Polyamines 50-59 ornithine decarboxylase 1 Homo sapiens 26-49 25813938-3 2015 Az reduces the cellular polyamine content by down-regulating both the enzyme catalysing polyamine biosynthesis, ornithine decarboxylase (ODC), and the uptake of polyamines. Polyamines 24-33 ornithine decarboxylase 1 Homo sapiens 112-135 25813938-3 2015 Az reduces the cellular polyamine content by down-regulating both the enzyme catalysing polyamine biosynthesis, ornithine decarboxylase (ODC), and the uptake of polyamines. Polyamines 24-33 ornithine decarboxylase 1 Homo sapiens 137-140 25813938-6 2015 In the present study, we have investigated the role of AzI1 in polyamine homeostasis and cell proliferation in breast cancer cells. Polyamines 63-72 centrosomal protein 131 Homo sapiens 55-59 25813938-8 2015 Inhibition of polyamine biosynthesis induced an even larger increase in the cellular AzI content, which remained significantly elevated during the 7-day experimental period. Polyamines 14-23 ornithine decarboxylase antizyme 1 Homo sapiens 85-88 25813938-13 2015 Taken together, the results indicate that AzI fulfils an essential regulatory function in polyamine homeostasis and cell proliferation. Polyamines 90-99 ornithine decarboxylase antizyme 1 Homo sapiens 42-45 25913073-5 2015 IL-1beta reduced the intracellular concentrations of overall primary metabolites especially those of amino acid, urea cycle, polyamine, S-adenosylmethione and glutathione synthetic pathways. Polyamines 125-134 interleukin 1 beta Homo sapiens 0-8 26178413-4 2015 Increased mRNA expressions of c-myc protooncogene and ornithine decarboxylase (ODC), biosynthetic enzyme of polyamines, were detected in Bag-1L+ cells, and western blots against the protein product of c-Myc and ODC confirmed these findings. Polyamines 108-118 MYC proto-oncogene, bHLH transcription factor Homo sapiens 30-35 26178413-4 2015 Increased mRNA expressions of c-myc protooncogene and ornithine decarboxylase (ODC), biosynthetic enzyme of polyamines, were detected in Bag-1L+ cells, and western blots against the protein product of c-Myc and ODC confirmed these findings. Polyamines 108-118 ornithine decarboxylase 1 Homo sapiens 54-77 26178413-4 2015 Increased mRNA expressions of c-myc protooncogene and ornithine decarboxylase (ODC), biosynthetic enzyme of polyamines, were detected in Bag-1L+ cells, and western blots against the protein product of c-Myc and ODC confirmed these findings. Polyamines 108-118 ornithine decarboxylase 1 Homo sapiens 79-82 26178413-5 2015 Once ODC, a c-Myc target, gets activated, polyamine biosynthesis increases. Polyamines 42-51 ornithine decarboxylase 1 Homo sapiens 5-8 26178413-5 2015 Once ODC, a c-Myc target, gets activated, polyamine biosynthesis increases. Polyamines 42-51 MYC proto-oncogene, bHLH transcription factor Homo sapiens 12-17 26178413-7 2015 On the contrary, when polyamine catabolic mechanisms were investigated, Bag-1 silencing suppressed biosynthesis of polyamines because of the downregulation of ODC and upregulation of PAO. Polyamines 22-31 BAG cochaperone 1 Homo sapiens 72-77 26178413-7 2015 On the contrary, when polyamine catabolic mechanisms were investigated, Bag-1 silencing suppressed biosynthesis of polyamines because of the downregulation of ODC and upregulation of PAO. Polyamines 22-31 ornithine decarboxylase 1 Homo sapiens 159-162 26178413-7 2015 On the contrary, when polyamine catabolic mechanisms were investigated, Bag-1 silencing suppressed biosynthesis of polyamines because of the downregulation of ODC and upregulation of PAO. Polyamines 115-125 BAG cochaperone 1 Homo sapiens 72-77 26178413-7 2015 On the contrary, when polyamine catabolic mechanisms were investigated, Bag-1 silencing suppressed biosynthesis of polyamines because of the downregulation of ODC and upregulation of PAO. Polyamines 115-125 ornithine decarboxylase 1 Homo sapiens 159-162 26178413-10 2015 In this line, our results suggested that Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ODC levels, leading to an increase of the polyamine content. Polyamines 182-191 BAG cochaperone 1 Homo sapiens 41-46 26178413-10 2015 In this line, our results suggested that Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ODC levels, leading to an increase of the polyamine content. Polyamines 182-191 MYC proto-oncogene, bHLH transcription factor Homo sapiens 88-93 26178413-10 2015 In this line, our results suggested that Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ODC levels, leading to an increase of the polyamine content. Polyamines 182-191 ornithine decarboxylase 1 Homo sapiens 140-143 26299433-3 2015 High concentrations of polyamines, which are aliphatic amines, are reported in exocrine and endocrine cells, with insulin-producing beta cells showing the highest concentrations. Polyamines 23-33 preproinsulin Danio rerio 114-121 26299433-6 2015 Moreover, we demonstrate that inhibition of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, phenocopies inhibition or knockdown of the enzyme deoxyhypusine synthase (DHS). Polyamines 103-112 ornithine decarboxylase 1 Danio rerio 44-67 26299433-6 2015 Moreover, we demonstrate that inhibition of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, phenocopies inhibition or knockdown of the enzyme deoxyhypusine synthase (DHS). Polyamines 103-112 ornithine decarboxylase 1 Danio rerio 69-72 26299433-6 2015 Moreover, we demonstrate that inhibition of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, phenocopies inhibition or knockdown of the enzyme deoxyhypusine synthase (DHS). Polyamines 103-112 deoxyhypusine synthase Danio rerio 177-199 26299433-7 2015 These data identify that the pancreatic requirement for polyamine biosynthesis is largely mediated through a requirement for spermidine for the downstream posttranslational modification of eIF5A by its enzymatic activator DHS, which in turn impacts mRNA translation. Polyamines 56-65 eukaryotic translation initiation factor 5A Danio rerio 189-194 25079701-1 2015 BACKGROUND: The study aimed to examine the association between genes encoding molecules in the ornithine decarboxylase (ODC)-polyamine pathway (ODC1, AMD1, NQO1, NOS2A, and OAZ2) and gastric cancer risk and whether the gene-phytoestrogen interaction modifies gastric cancer risk. Polyamines 125-134 ornithine decarboxylase 1 Homo sapiens 95-118 25079701-1 2015 BACKGROUND: The study aimed to examine the association between genes encoding molecules in the ornithine decarboxylase (ODC)-polyamine pathway (ODC1, AMD1, NQO1, NOS2A, and OAZ2) and gastric cancer risk and whether the gene-phytoestrogen interaction modifies gastric cancer risk. Polyamines 125-134 ornithine decarboxylase 1 Homo sapiens 120-123 25079701-1 2015 BACKGROUND: The study aimed to examine the association between genes encoding molecules in the ornithine decarboxylase (ODC)-polyamine pathway (ODC1, AMD1, NQO1, NOS2A, and OAZ2) and gastric cancer risk and whether the gene-phytoestrogen interaction modifies gastric cancer risk. Polyamines 125-134 ornithine decarboxylase 1 Homo sapiens 144-148 25079701-1 2015 BACKGROUND: The study aimed to examine the association between genes encoding molecules in the ornithine decarboxylase (ODC)-polyamine pathway (ODC1, AMD1, NQO1, NOS2A, and OAZ2) and gastric cancer risk and whether the gene-phytoestrogen interaction modifies gastric cancer risk. Polyamines 125-134 adenosylmethionine decarboxylase 1 Homo sapiens 150-154 25079701-1 2015 BACKGROUND: The study aimed to examine the association between genes encoding molecules in the ornithine decarboxylase (ODC)-polyamine pathway (ODC1, AMD1, NQO1, NOS2A, and OAZ2) and gastric cancer risk and whether the gene-phytoestrogen interaction modifies gastric cancer risk. Polyamines 125-134 NAD(P)H quinone dehydrogenase 1 Homo sapiens 156-160 25079701-1 2015 BACKGROUND: The study aimed to examine the association between genes encoding molecules in the ornithine decarboxylase (ODC)-polyamine pathway (ODC1, AMD1, NQO1, NOS2A, and OAZ2) and gastric cancer risk and whether the gene-phytoestrogen interaction modifies gastric cancer risk. Polyamines 125-134 nitric oxide synthase 2 Homo sapiens 162-167 25079701-1 2015 BACKGROUND: The study aimed to examine the association between genes encoding molecules in the ornithine decarboxylase (ODC)-polyamine pathway (ODC1, AMD1, NQO1, NOS2A, and OAZ2) and gastric cancer risk and whether the gene-phytoestrogen interaction modifies gastric cancer risk. Polyamines 125-134 ornithine decarboxylase antizyme 2 Homo sapiens 173-177 25079701-9 2015 CONCLUSIONS: Our findings suggest that common variants in the genes involved in the ODC pathway may contribute to the risk of gastric cancer possibly by modulating ODC polyamine biosynthesis or by interaction between isoflavones and NQO1, OAZ2, and AMD1. Polyamines 168-177 ornithine decarboxylase 1 Homo sapiens 84-87 25079701-9 2015 CONCLUSIONS: Our findings suggest that common variants in the genes involved in the ODC pathway may contribute to the risk of gastric cancer possibly by modulating ODC polyamine biosynthesis or by interaction between isoflavones and NQO1, OAZ2, and AMD1. Polyamines 168-177 ornithine decarboxylase 1 Homo sapiens 164-167 25079701-9 2015 CONCLUSIONS: Our findings suggest that common variants in the genes involved in the ODC pathway may contribute to the risk of gastric cancer possibly by modulating ODC polyamine biosynthesis or by interaction between isoflavones and NQO1, OAZ2, and AMD1. Polyamines 168-177 ornithine decarboxylase antizyme 2 Homo sapiens 239-243 25079701-9 2015 CONCLUSIONS: Our findings suggest that common variants in the genes involved in the ODC pathway may contribute to the risk of gastric cancer possibly by modulating ODC polyamine biosynthesis or by interaction between isoflavones and NQO1, OAZ2, and AMD1. Polyamines 168-177 adenosylmethionine decarboxylase 1 Homo sapiens 249-253 25650699-9 2015 The PA levels are regulated by ornithine decarboxylase (ODC), the rate-limiting enzyme in PA biosynthesis. Polyamines 4-6 ornithine decarboxylase 1 Homo sapiens 31-54 25959060-1 2015 Low brain expression of the spermidine/spermine N-1 acetyltransferase (SAT1) gene, the rate-limiting enzyme involved in catabolism of polyamines that mediate the polyamine stress response (PSR), has been reported in depressed suicides. Polyamines 134-144 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 71-75 25959060-1 2015 Low brain expression of the spermidine/spermine N-1 acetyltransferase (SAT1) gene, the rate-limiting enzyme involved in catabolism of polyamines that mediate the polyamine stress response (PSR), has been reported in depressed suicides. Polyamines 134-143 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 71-75 26171056-1 2015 Ornithine decarboxylase (ODC) is a significant rate-limiting enzyme in polyamine synthesis, required for normal cell growth, and is highly expressed in various malignancies, including colorectal and breast cancer. Polyamines 71-80 ornithine decarboxylase 1 Homo sapiens 0-23 26171056-1 2015 Ornithine decarboxylase (ODC) is a significant rate-limiting enzyme in polyamine synthesis, required for normal cell growth, and is highly expressed in various malignancies, including colorectal and breast cancer. Polyamines 71-80 ornithine decarboxylase 1 Homo sapiens 25-28 25885476-4 2015 Polyamine (PA) biosynthesis and degradation capacity increased in parallel with increasing GAD activity. Polyamines 0-9 glutamate decarboxylase Cucumis melo 91-94 25885476-4 2015 Polyamine (PA) biosynthesis and degradation capacity increased in parallel with increasing GAD activity. Polyamines 11-13 glutamate decarboxylase Cucumis melo 91-94 26835380-4 2015 DFMO is an irreversible inhibitor of ornithine decarboxylase (Odc), a MYC target gene, bona fide oncogene, and the rate-limiting enzyme in polyamine synthesis. Polyamines 139-148 ornithine decarboxylase 1 Homo sapiens 37-60 26835380-4 2015 DFMO is an irreversible inhibitor of ornithine decarboxylase (Odc), a MYC target gene, bona fide oncogene, and the rate-limiting enzyme in polyamine synthesis. Polyamines 139-148 ornithine decarboxylase 1 Homo sapiens 62-65 26835380-6 2015 However, polyamines are also critical for mammalian cell proliferation and the finding that MYC coordinately regulates all aspects of polyamine metabolism suggests polyamines may be required to support cancer promotion by MYC. Polyamines 164-174 MYC proto-oncogene, bHLH transcription factor Homo sapiens 92-95 26835380-6 2015 However, polyamines are also critical for mammalian cell proliferation and the finding that MYC coordinately regulates all aspects of polyamine metabolism suggests polyamines may be required to support cancer promotion by MYC. Polyamines 164-174 MYC proto-oncogene, bHLH transcription factor Homo sapiens 222-225 26835380-8 2015 Moreover, polyamine depletion regimens exert potent anti-tumor activity in pre-clinical models of established neuroblastoma as well, in combination with numerous chemotherapeutic agents and even in tumors with unfavorable genetic features such as MYCN, ALK or TP53 mutation. Polyamines 10-19 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 247-251 26835380-8 2015 Moreover, polyamine depletion regimens exert potent anti-tumor activity in pre-clinical models of established neuroblastoma as well, in combination with numerous chemotherapeutic agents and even in tumors with unfavorable genetic features such as MYCN, ALK or TP53 mutation. Polyamines 10-19 ALK receptor tyrosine kinase Homo sapiens 253-256 26835380-8 2015 Moreover, polyamine depletion regimens exert potent anti-tumor activity in pre-clinical models of established neuroblastoma as well, in combination with numerous chemotherapeutic agents and even in tumors with unfavorable genetic features such as MYCN, ALK or TP53 mutation. Polyamines 10-19 tumor protein p53 Homo sapiens 260-264 26093909-4 2015 We and others previously showed that polyamines (PA) like spermidine and spermine are essential for NB tumorigenesis and that DFMO, an inhibitor of the key PA synthesis gene product ODC, is effective both in vitro and in vivo, securing its evaluation in NB clinical trials. Polyamines 156-158 ornithine decarboxylase 1 Homo sapiens 182-185 26011388-2 2015 We have previously shown that PAs facilitate diffusion of Lucifer Yellow through astrocytic gap junctions in acute brain slices; therefore, we hypothesized that spermine can regulate Cx43-mediated (as the most abundant Cx in astrocytes) gap junctional communication. Polyamines 30-33 gap junction protein alpha 1 Homo sapiens 183-187 25849284-0 2015 Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N1-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells. Polyamines 17-27 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 73-115 25849284-0 2015 Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N1-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells. Polyamines 17-27 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 117-121 25849284-2 2015 Transduction of human embryonic kidney (HEK) 293T cells with an adenovirus encoding a key polyamine catabolic enzyme, spermidine N1-acetyltransferase 1 (SSAT1)/SAT1 (AdSAT1), leads to a rapid depletion of spermidine and spermine, arrest in cell growth and a decline in cell viability. Polyamines 90-99 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 153-158 25849284-2 2015 Transduction of human embryonic kidney (HEK) 293T cells with an adenovirus encoding a key polyamine catabolic enzyme, spermidine N1-acetyltransferase 1 (SSAT1)/SAT1 (AdSAT1), leads to a rapid depletion of spermidine and spermine, arrest in cell growth and a decline in cell viability. Polyamines 90-99 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 154-158 25849284-4 2015 Apoptosis in the polyamine-depleted cells occurs by the mitochondrial intrinsic pathway, as evidenced by loss of mitochondrial membrane potential, increase in pro-apoptotic Bax, decrease in anti-apoptotic Bcl-xl, Bcl2 and Mcl-1 and release of cytochrome c from mitochondria, upon transduction with AdSAT1. Polyamines 17-26 BCL2 associated X, apoptosis regulator Homo sapiens 173-176 25849284-4 2015 Apoptosis in the polyamine-depleted cells occurs by the mitochondrial intrinsic pathway, as evidenced by loss of mitochondrial membrane potential, increase in pro-apoptotic Bax, decrease in anti-apoptotic Bcl-xl, Bcl2 and Mcl-1 and release of cytochrome c from mitochondria, upon transduction with AdSAT1. Polyamines 17-26 BCL2 apoptosis regulator Homo sapiens 213-217 25849284-4 2015 Apoptosis in the polyamine-depleted cells occurs by the mitochondrial intrinsic pathway, as evidenced by loss of mitochondrial membrane potential, increase in pro-apoptotic Bax, decrease in anti-apoptotic Bcl-xl, Bcl2 and Mcl-1 and release of cytochrome c from mitochondria, upon transduction with AdSAT1. Polyamines 17-26 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 222-227 25849284-4 2015 Apoptosis in the polyamine-depleted cells occurs by the mitochondrial intrinsic pathway, as evidenced by loss of mitochondrial membrane potential, increase in pro-apoptotic Bax, decrease in anti-apoptotic Bcl-xl, Bcl2 and Mcl-1 and release of cytochrome c from mitochondria, upon transduction with AdSAT1. Polyamines 17-26 cytochrome c, somatic Homo sapiens 243-255 25818703-4 2015 The suitability of this methodology is further corroborated through the examination of the metabolic changes in the polyamines pathway produced in colon cancer HT-29 cells by difluoromethylornithine (DFMO), a known potent ornithine decarboxylase inhibitor. Polyamines 116-126 ornithine decarboxylase 1 Homo sapiens 222-245 25650699-9 2015 The PA levels are regulated by ornithine decarboxylase (ODC), the rate-limiting enzyme in PA biosynthesis. Polyamines 4-6 ornithine decarboxylase 1 Homo sapiens 56-59 25650699-9 2015 The PA levels are regulated by ornithine decarboxylase (ODC), the rate-limiting enzyme in PA biosynthesis. Polyamines 90-92 ornithine decarboxylase 1 Homo sapiens 31-54 25650699-9 2015 The PA levels are regulated by ornithine decarboxylase (ODC), the rate-limiting enzyme in PA biosynthesis. Polyamines 90-92 ornithine decarboxylase 1 Homo sapiens 56-59 25788572-6 2015 Cellular polyamines were found to regulate miR-29b expression by altering JunD abundance, since the increase in miR-29b expression levels in polyamine-deficient cells was abolished by JunD silencing. Polyamines 9-19 microRNA 29b-1 Homo sapiens 43-50 25945809-4 2015 Our Lat2 homology model is based on 2 crystal structures of the homologous 12-transmembrane helix transporters arginine/agmatine antiporter and amino acid/polyamine/organocation transporter. Polyamines 155-164 solute carrier family 7 member 8 L homeolog Xenopus laevis 4-8 26030749-2 2015 As a rate-limiting enzyme of the polyamine biosynthetic pathway, S-adenosylmethionine decarboxylase (AdoMetDC) has been an attractive drug target. Polyamines 33-42 adenosylmethionine decarboxylase 1 Homo sapiens 65-99 26030749-2 2015 As a rate-limiting enzyme of the polyamine biosynthetic pathway, S-adenosylmethionine decarboxylase (AdoMetDC) has been an attractive drug target. Polyamines 33-42 adenosylmethionine decarboxylase 1 Homo sapiens 101-109 26018967-8 2015 Patients with the minor T-allele at rs2302616 of the ODC gene had higher baseline levels (p=0.02) of, and larger decreases in, total urinary polyamines during the first cycle of DFMO therapy (p=0.003) and had median progression free survival (PFS) that was over three times longer, compared to patients with the major G allele at this locus although this last result was not statistically significant (p=0.07). Polyamines 141-151 ornithine decarboxylase 1 Homo sapiens 53-56 26018967-12 2015 Children with the minor T allele at rs2302616 of the ODC gene with relapsed or refractory NB had higher levels of urinary polyamine markers and responded better to therapy containing DFMO, compared to those with the major G allele at this locus. Polyamines 122-131 ornithine decarboxylase 1 Homo sapiens 53-56 25788572-6 2015 Cellular polyamines were found to regulate miR-29b expression by altering JunD abundance, since the increase in miR-29b expression levels in polyamine-deficient cells was abolished by JunD silencing. Polyamines 9-19 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 74-78 25788572-6 2015 Cellular polyamines were found to regulate miR-29b expression by altering JunD abundance, since the increase in miR-29b expression levels in polyamine-deficient cells was abolished by JunD silencing. Polyamines 9-19 microRNA 29b-1 Homo sapiens 112-119 25788572-6 2015 Cellular polyamines were found to regulate miR-29b expression by altering JunD abundance, since the increase in miR-29b expression levels in polyamine-deficient cells was abolished by JunD silencing. Polyamines 9-19 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 184-188 25788572-6 2015 Cellular polyamines were found to regulate miR-29b expression by altering JunD abundance, since the increase in miR-29b expression levels in polyamine-deficient cells was abolished by JunD silencing. Polyamines 9-18 microRNA 29b-1 Homo sapiens 43-50 25788572-6 2015 Cellular polyamines were found to regulate miR-29b expression by altering JunD abundance, since the increase in miR-29b expression levels in polyamine-deficient cells was abolished by JunD silencing. Polyamines 9-18 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 74-78 25788572-6 2015 Cellular polyamines were found to regulate miR-29b expression by altering JunD abundance, since the increase in miR-29b expression levels in polyamine-deficient cells was abolished by JunD silencing. Polyamines 9-18 microRNA 29b-1 Homo sapiens 112-119 25788572-6 2015 Cellular polyamines were found to regulate miR-29b expression by altering JunD abundance, since the increase in miR-29b expression levels in polyamine-deficient cells was abolished by JunD silencing. Polyamines 9-18 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 184-188 25808495-8 2015 Depletion of cellular polyamines also increased CELF1 and enhanced CELF1 association with Myc mRNA, thus suppressing MYC translation. Polyamines 22-32 CUGBP Elav-like family member 1 Homo sapiens 48-53 25808495-8 2015 Depletion of cellular polyamines also increased CELF1 and enhanced CELF1 association with Myc mRNA, thus suppressing MYC translation. Polyamines 22-32 CUGBP Elav-like family member 1 Homo sapiens 67-72 25808495-8 2015 Depletion of cellular polyamines also increased CELF1 and enhanced CELF1 association with Myc mRNA, thus suppressing MYC translation. Polyamines 22-32 MYC proto-oncogene, bHLH transcription factor Homo sapiens 90-93 25808495-8 2015 Depletion of cellular polyamines also increased CELF1 and enhanced CELF1 association with Myc mRNA, thus suppressing MYC translation. Polyamines 22-32 MYC proto-oncogene, bHLH transcription factor Homo sapiens 117-120 25850771-1 2015 Ecto-5"-nucleotidase (ecto-5"-NT, 5"-NT, eN, CD73) is a membrane ecto-enzyme that is primarily responsible for the extracellular production of adenosine from AMP. Polyamines 41-43 5'-nucleotidase ecto Homo sapiens 0-20 25724339-5 2015 Also, OAZ1 coding for ornithine decarboxylase (ODC) antizyme and TPO1 coding for the polyamine transport protein were disrupted to increase intracellular SPD levels through alleviation of feedback inhibition on ODC and prevention of SPD excretion, respectively. Polyamines 85-94 Oaz1p Saccharomyces cerevisiae S288C 6-10 25934505-8 2015 The increase in spermidine was accompanied by reduced levels of nicotinamide N-methyltransferase, which promotes polyamine synthesis, enables nicotinamide salvage to regenerate NAD(+), and is associated with obesity resistance. Polyamines 113-122 nicotinamide N-methyltransferase Mus musculus 64-96 25724339-5 2015 Also, OAZ1 coding for ornithine decarboxylase (ODC) antizyme and TPO1 coding for the polyamine transport protein were disrupted to increase intracellular SPD levels through alleviation of feedback inhibition on ODC and prevention of SPD excretion, respectively. Polyamines 85-94 Tpo1p Saccharomyces cerevisiae S288C 65-69 25461272-6 2015 Under these circumstances, the CD44 knockdown suppressed polyamines, GSH and energy charges not only in metastatic tumors but also in the host liver. Polyamines 57-67 CD44 molecule (Indian blood group) Homo sapiens 31-35 25231394-1 2015 Spermidine/spermine N (1)-acetyltransferase (SSAT) is a catabolic regulator of polyamines, ubiquitous molecules essential for cell proliferation and differentiation. Polyamines 79-89 spermidine/spermine N1-acetyl transferase 1 Mus musculus 45-49 26112945-1 2015 AIM: To study the influence of polyamine metabolism inhibitors on the growth, metastasis and ornithine decarboxylase (ODC) activity of Lewis lung carcinoma. Polyamines 31-40 ornithine decarboxylase, structural 1 Mus musculus 93-116 26112945-1 2015 AIM: To study the influence of polyamine metabolism inhibitors on the growth, metastasis and ornithine decarboxylase (ODC) activity of Lewis lung carcinoma. Polyamines 31-40 ornithine decarboxylase, structural 1 Mus musculus 118-121 26112945-6 2015 Determination of ODC - the key enzyme of the polyamine synthesis - in the samples of experimental tumors was performed by method of Luqman S. RESULTS: Administration of DFMO or it"s combination with nor-NOHA resulted in the decrease of tumor growth rate, number and volume of lung metastases and was accompanied with reduced ODC activity in tumor tissue. Polyamines 45-54 ornithine decarboxylase, structural 1 Mus musculus 17-20 25231394-8 2015 The polyamine pattern in osteoblasts of SSAT mice was distorted in comparison with wild-type mice. Polyamines 4-13 spermidine/spermine N1-acetyl transferase 1 Mus musculus 40-44 25231394-9 2015 However, treatment of osteoblasts with a SSAT-inducing functional polyamine analogue suggested that defective osteoblastogenesis resulted rather from other consequences of enhanced SSAT activity than lowered levels of the higher polyamines. Polyamines 66-75 spermidine/spermine N1-acetyl transferase 1 Mus musculus 41-45 25231394-9 2015 However, treatment of osteoblasts with a SSAT-inducing functional polyamine analogue suggested that defective osteoblastogenesis resulted rather from other consequences of enhanced SSAT activity than lowered levels of the higher polyamines. Polyamines 66-75 spermidine/spermine N1-acetyl transferase 1 Mus musculus 181-185 25231394-9 2015 However, treatment of osteoblasts with a SSAT-inducing functional polyamine analogue suggested that defective osteoblastogenesis resulted rather from other consequences of enhanced SSAT activity than lowered levels of the higher polyamines. Polyamines 229-239 spermidine/spermine N1-acetyl transferase 1 Mus musculus 41-45 25623305-0 2015 A novel polyamine allosteric site of SpeG from Vibrio cholerae is revealed by its dodecameric structure. Polyamines 8-17 striated muscle enriched protein kinase Homo sapiens 37-41 25623305-1 2015 Spermidine N-acetyltransferase, encoded by the gene speG, catalyzes the initial step in the degradation of polyamines and is a critical enzyme for determining the polyamine concentrations in bacteria. Polyamines 107-117 striated muscle enriched protein kinase Homo sapiens 52-56 25623305-1 2015 Spermidine N-acetyltransferase, encoded by the gene speG, catalyzes the initial step in the degradation of polyamines and is a critical enzyme for determining the polyamine concentrations in bacteria. Polyamines 107-116 striated muscle enriched protein kinase Homo sapiens 52-56 25623305-11 2015 Our results provide a fundamental understanding of the bacterial SpeG enzyme, which will be key toward understanding the regulation of polyamine levels in bacteria during pathogenesis. Polyamines 135-144 striated muscle enriched protein kinase Homo sapiens 65-69 25807386-4 2015 Increased arginase can also provide ornithine for synthesis of polyamines via ornithine decarboxylase (ODC) and proline/collagen via ornithine aminotransferase (OAT), leading to vascular cell proliferation and collagen formation, respectively. Polyamines 63-73 ornithine decarboxylase, structural 1 Mus musculus 78-101 25807386-4 2015 Increased arginase can also provide ornithine for synthesis of polyamines via ornithine decarboxylase (ODC) and proline/collagen via ornithine aminotransferase (OAT), leading to vascular cell proliferation and collagen formation, respectively. Polyamines 63-73 ornithine decarboxylase, structural 1 Mus musculus 103-106 25577734-6 2015 As determinants of the first committed step in PA biosynthesis, arginine and ornithine decarboxylase (ADC and ODC, respectively) activities were below levels of detectability in resting tubers and expression of genes encoding these two enzymes was low. Polyamines 47-49 ornithine decarboxylase 1 Homo sapiens 77-100 25593318-2 2015 The oncogene n-myc is known to potentiate polyamine metabolism. Polyamines 42-51 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 13-18 25593318-9 2015 Combined therapies targeting glucose metabolism and polyamine synthesis could be effective in the treatment of n-myc-expressing tumors. Polyamines 52-61 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 111-116 25742129-3 2015 BACKGROUND/METHODOLOGY: We have recently reported that two SOD mimetic compounds, the Mn(II) complexes of the polyamines Pytren2Q and Pytren4Q, displayed high antioxidant activity in bacteria and yeast. Polyamines 110-120 superoxide dismutase 2, mitochondrial Mus musculus 59-62 25471600-3 2015 However, polyamines can also be covalently conjugated to proteins by transglutaminase 2 (TG2). Polyamines 9-19 transglutaminase 2 Homo sapiens 69-87 25471600-3 2015 However, polyamines can also be covalently conjugated to proteins by transglutaminase 2 (TG2). Polyamines 9-19 transglutaminase 2 Homo sapiens 89-92 25471600-5 2015 It is anticipated that protein polyamine conjugation may affect the protein-protein interaction, protein localization, and protein function of the TG2 substrates. Polyamines 31-40 transglutaminase 2 Homo sapiens 147-150 25502809-10 2015 mRNA expression analysis indicated a shift in the arginine metabolism from NO formation to polyamine metabolism starting within 2 hours (h) of reperfusion and translated into protein expression within 24 h. Inhibition of the TNF-alpha pathway and captopril attenuated these delayed effects on post-ischaemic recovery. Polyamines 91-100 tumor necrosis factor Rattus norvegicus 225-234 25653279-2 2015 Arginine stimulates proliferation and interferon tau production by ovine trophectoderm cells via nitric oxide and polyamine-TSC2-MTOR signaling pathways. Polyamines 114-123 TSC complex subunit 2 Homo sapiens 124-128 25653279-2 2015 Arginine stimulates proliferation and interferon tau production by ovine trophectoderm cells via nitric oxide and polyamine-TSC2-MTOR signaling pathways. Polyamines 114-123 mechanistic target of rapamycin kinase Homo sapiens 129-133 25763008-9 2015 Polyamines, which aid in nucleoprotein complex assembly in the nucleolus, increase further during cell stress, and appear to have an important role in the autoimmune disease process. Polyamines 0-10 activation induced cytidine deaminase Homo sapiens 18-21 25435252-2 2015 In this work it was discovered that porphyrins bearing 2-4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains. Polyamines 185-194 potassium voltage-gated channel subfamily A member 2 Homo sapiens 140-145 25153488-6 2015 The released BENSpm depletes cellular levels of spermidine and spermine and upregulates polyamine catabolic enzymes spermine/spermidine N(1)-acetyltransferase (SSAT) and spermine oxidase (SMO). Polyamines 88-97 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 160-164 25153488-6 2015 The released BENSpm depletes cellular levels of spermidine and spermine and upregulates polyamine catabolic enzymes spermine/spermidine N(1)-acetyltransferase (SSAT) and spermine oxidase (SMO). Polyamines 88-97 spermine oxidase Homo sapiens 170-186 25153488-6 2015 The released BENSpm depletes cellular levels of spermidine and spermine and upregulates polyamine catabolic enzymes spermine/spermidine N(1)-acetyltransferase (SSAT) and spermine oxidase (SMO). Polyamines 88-97 spermine oxidase Homo sapiens 188-191 25425115-0 2015 Polyamine stimulation of eEF1A synthesis based on the unusual position of a complementary sequence to 18S rRNA in eEF1A mRNA. Polyamines 0-9 eukaryotic translation elongation factor 1 alpha 2 Mus musculus 25-30 25425115-0 2015 Polyamine stimulation of eEF1A synthesis based on the unusual position of a complementary sequence to 18S rRNA in eEF1A mRNA. Polyamines 0-9 eukaryotic translation elongation factor 1 alpha 2 Mus musculus 114-119 25425115-6 2015 In eEF1A mRNA, the CR sequence was located at -33 to -39 upstream from the initiation codon AUG, and polyamines stimulated eEF1A synthesis about threefold. Polyamines 101-111 eukaryotic translation elongation factor 1 alpha 2 Mus musculus 3-8 25425115-6 2015 In eEF1A mRNA, the CR sequence was located at -33 to -39 upstream from the initiation codon AUG, and polyamines stimulated eEF1A synthesis about threefold. Polyamines 101-111 eukaryotic translation elongation factor 1 alpha 2 Mus musculus 123-128 25425115-7 2015 When the CR sequence was shifted to -22 to -28 upstream from the AUG, eEF1A synthesis increased in polyamine-reduced cells and the degree of polyamine stimulation decreased greatly. Polyamines 99-108 eukaryotic translation elongation factor 1 alpha 2 Mus musculus 70-75 25559387-1 2015 S-adenosyl-L-methionine (SAM) synthase (SAMS) catalyze the biosynthesis of SAM, which is a precursor for ethylene and polyamines, and a methyl donor for a number of biomolecules. Polyamines 118-128 methionine adenosyltransferase 1A Homo sapiens 40-44 25530671-1 2015 A dicarboxylated ethynylarene was shown to behave as a fluorescent chemosensor for millimolar concentrations of polyamines when mixed with Cd(II), Pb(II) or Zn(II) ions at micromolar concentrations. Polyamines 112-122 submaxillary gland androgen regulated protein 3B Homo sapiens 147-153 25592131-9 2015 CONCLUSIONS: The major findings from this study are: (i) although polyamines contribute to defense in some plant-pathogen interactions, their production is induced in susceptible wheat during interactions with Hessian fly larvae without contributing to defense, and (ii) due to low abundance of transcripts encoding the rate-limiting ornithine decarboxylase enzyme in the larval polyamine pathway the source of polyamines found in virulent larvae is plausibly wheat-derived. Polyamines 66-75 ornithine decarboxylase Triticum aestivum 334-357 25317587-5 2015 Increasing cellular polyamines due to overexpression of ornithine decarboxylase (ODC) enhanced menin translation by reducing miR-29b, whereas polyamine depletion by inhibiting ODC increased it, thus suppressing menin expression. Polyamines 20-30 ornithine decarboxylase 1 Rattus norvegicus 56-79 25317587-5 2015 Increasing cellular polyamines due to overexpression of ornithine decarboxylase (ODC) enhanced menin translation by reducing miR-29b, whereas polyamine depletion by inhibiting ODC increased it, thus suppressing menin expression. Polyamines 20-30 ornithine decarboxylase 1 Rattus norvegicus 81-84 25317587-5 2015 Increasing cellular polyamines due to overexpression of ornithine decarboxylase (ODC) enhanced menin translation by reducing miR-29b, whereas polyamine depletion by inhibiting ODC increased it, thus suppressing menin expression. Polyamines 20-30 menin 1 Rattus norvegicus 95-100 25317587-5 2015 Increasing cellular polyamines due to overexpression of ornithine decarboxylase (ODC) enhanced menin translation by reducing miR-29b, whereas polyamine depletion by inhibiting ODC increased it, thus suppressing menin expression. Polyamines 20-30 menin 1 Rattus norvegicus 211-216 25317587-5 2015 Increasing cellular polyamines due to overexpression of ornithine decarboxylase (ODC) enhanced menin translation by reducing miR-29b, whereas polyamine depletion by inhibiting ODC increased it, thus suppressing menin expression. Polyamines 20-29 ornithine decarboxylase 1 Rattus norvegicus 56-79 25317587-5 2015 Increasing cellular polyamines due to overexpression of ornithine decarboxylase (ODC) enhanced menin translation by reducing miR-29b, whereas polyamine depletion by inhibiting ODC increased it, thus suppressing menin expression. Polyamines 20-29 ornithine decarboxylase 1 Rattus norvegicus 81-84 25317587-5 2015 Increasing cellular polyamines due to overexpression of ornithine decarboxylase (ODC) enhanced menin translation by reducing miR-29b, whereas polyamine depletion by inhibiting ODC increased it, thus suppressing menin expression. Polyamines 20-29 menin 1 Rattus norvegicus 95-100 25317587-5 2015 Increasing cellular polyamines due to overexpression of ornithine decarboxylase (ODC) enhanced menin translation by reducing miR-29b, whereas polyamine depletion by inhibiting ODC increased it, thus suppressing menin expression. Polyamines 20-29 menin 1 Rattus norvegicus 211-216 25311224-7 2015 The resistant profile caused by p53 defect also caused a cell type-specific response to PA pool depletion and SSAT overexpression. Polyamines 88-90 tumor protein p53 Homo sapiens 32-35 25399055-7 2015 Here we present some PCD plant models, focusing on the role of the enzyme responsible for PA conjugation to proteins: transglutaminase (TGase), an enzyme linked with the process of PCD also in some animal models. Polyamines 90-92 transglutaminase 1 Homo sapiens 118-134 25399055-7 2015 Here we present some PCD plant models, focusing on the role of the enzyme responsible for PA conjugation to proteins: transglutaminase (TGase), an enzyme linked with the process of PCD also in some animal models. Polyamines 90-92 transglutaminase 1 Homo sapiens 136-141 26514486-10 2015 CONCLUSIONS: These findings strongly suggest that in HNSCCs, the ARG1 pathway is stimulated leading to the formation of polyamines as indicated by higher ODC expression, which promote tumor growth. Polyamines 120-130 arginase 1 Homo sapiens 65-69 26514486-10 2015 CONCLUSIONS: These findings strongly suggest that in HNSCCs, the ARG1 pathway is stimulated leading to the formation of polyamines as indicated by higher ODC expression, which promote tumor growth. Polyamines 120-130 ornithine decarboxylase 1 Homo sapiens 154-157 25516968-5 2015 Expression of Odc1, the rate-limiting enzyme in the conversion of ornithine into putrescine in the synthesis of polyamines, is reduced in Mga mutant cells, and the survival of mutant ICM cells as well as ESCs is rescued in culture by the addition of exogenous putrescine. Polyamines 112-122 ornithine decarboxylase, structural 1 Mus musculus 14-18 25516968-6 2015 These results suggest a mechanism whereby Mga influences pluripotent cell survival through regulation of the polyamine pool in pluripotent cells of the embryo, whether they are in a proliferative or quiescent state. Polyamines 109-118 MAX gene associated Mus musculus 42-45 25216923-0 2014 Natural polyamines inhibit the migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pathways. Polyamines 8-18 protein tyrosine kinase 2 beta Homo sapiens 79-83 25218693-9 2014 GENERAL SIGNIFICANCE: The shift in the ariginine-metabolism from the iNOS/NO axis to the arginase/polyamine axis is guided by Th1/Th2 cytokines ratio and plays an important role in gastric ulcer-healing. Polyamines 98-107 negative elongation factor complex member C/D, Th1l Mus musculus 126-129 25218693-9 2014 GENERAL SIGNIFICANCE: The shift in the ariginine-metabolism from the iNOS/NO axis to the arginase/polyamine axis is guided by Th1/Th2 cytokines ratio and plays an important role in gastric ulcer-healing. Polyamines 98-107 heart and neural crest derivatives expressed 2 Mus musculus 130-133 25248858-1 2014 Ornithine decarboxylase (ODC) is the key rate-limiting enzyme in the polyamine synthesis pathway and it is overexpressed in a variety of cancers. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 0-23 25248858-1 2014 Ornithine decarboxylase (ODC) is the key rate-limiting enzyme in the polyamine synthesis pathway and it is overexpressed in a variety of cancers. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 25-28 25248858-2 2014 We found that polyamine synthesis and modulation of ODC signaling occurs at early stages of pancreatic precursor lesions and increases as the tumor progresses in Kras-activated p48(Cre/+)-LSL-Kras(G12D/+) mice. Polyamines 14-23 ornithine decarboxylase, structural 1 Mus musculus 52-55 25248858-2 2014 We found that polyamine synthesis and modulation of ODC signaling occurs at early stages of pancreatic precursor lesions and increases as the tumor progresses in Kras-activated p48(Cre/+)-LSL-Kras(G12D/+) mice. Polyamines 14-23 Kirsten rat sarcoma viral oncogene homolog Mus musculus 162-166 25248858-2 2014 We found that polyamine synthesis and modulation of ODC signaling occurs at early stages of pancreatic precursor lesions and increases as the tumor progresses in Kras-activated p48(Cre/+)-LSL-Kras(G12D/+) mice. Polyamines 14-23 interferon regulatory factor 9 Mus musculus 177-180 25248858-2 2014 We found that polyamine synthesis and modulation of ODC signaling occurs at early stages of pancreatic precursor lesions and increases as the tumor progresses in Kras-activated p48(Cre/+)-LSL-Kras(G12D/+) mice. Polyamines 14-23 Kirsten rat sarcoma viral oncogene homolog Mus musculus 192-196 25214240-10 2014 However, the silencing of spermidine-spermineacetyltransferase (SSAT), a key enzyme at polyamine catabolic machinery prevented the EBR-induced apoptosis. Polyamines 87-96 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 64-68 25301005-0 2014 Vascular smooth muscle cell proliferation depends on caveolin-1-regulated polyamine uptake. Polyamines 74-83 caveolin 1, caveolae protein Mus musculus 53-63 25301005-2 2014 Cav-1 (caveolin-1) was recently reported to regulate polyamine uptake in intestinal epithelial cells. Polyamines 53-62 caveolin 1, caveolae protein Mus musculus 0-5 25301005-2 2014 Cav-1 (caveolin-1) was recently reported to regulate polyamine uptake in intestinal epithelial cells. Polyamines 53-62 caveolin 1, caveolae protein Mus musculus 7-17 25301005-3 2014 The aim of the present study was to assess the importance of Cav-1 for VSMC polyamine uptake and its impact on cell proliferation and migration. Polyamines 76-85 caveolin 1, caveolae protein Mus musculus 61-66 25301005-4 2014 Cav-1 KO (knockout) mouse aortic cells showed increased polyamine uptake and elevated proliferation and migration compared with WT (wild-type) cells. Polyamines 56-65 caveolin 1, caveolae protein Mus musculus 0-5 25301005-7 2014 Cav-1 KO cells were hyper-proliferative in the presence but not in the absence of extracellular polyamines, and, moreover, supplementation with exogenous polyamines promoted proliferation in Cav-1 KO but not in WT cells. Polyamines 154-164 caveolin 1, caveolae protein Mus musculus 0-5 25301005-7 2014 Cav-1 KO cells were hyper-proliferative in the presence but not in the absence of extracellular polyamines, and, moreover, supplementation with exogenous polyamines promoted proliferation in Cav-1 KO but not in WT cells. Polyamines 154-164 caveolin 1, caveolae protein Mus musculus 191-196 25416954-4 2014 The plastid-localized PII signaling protein controls, in a glutamine-dependent manner, the key enzyme of the ornithine synthesis pathway, N-acetyl-l-glutamate kinase (NAGK), that leads to arginine and polyamine formation. Polyamines 201-210 N-acetyl-l-glutamate kinase Arabidopsis thaliana 138-165 25416954-4 2014 The plastid-localized PII signaling protein controls, in a glutamine-dependent manner, the key enzyme of the ornithine synthesis pathway, N-acetyl-l-glutamate kinase (NAGK), that leads to arginine and polyamine formation. Polyamines 201-210 N-acetyl-l-glutamate kinase Arabidopsis thaliana 167-171 25449949-1 2015 Ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthesis pathway, is significant in the synthesis of trypanothione, T(SH)2, the major reduced thiol which is responsible for the modulation of the immune response and pathogenesis in visceral leishmaniasis. Polyamines 57-66 ornithine decarboxylase 1 Homo sapiens 0-23 25415050-4 2015 Polyamines, regulated by ornithine decarboxylase (ODC) modulate eIF-5A which is a direct regulator of the LIN28/Let-7 axis. Polyamines 0-10 ornithine decarboxylase 1 Homo sapiens 25-48 25415050-4 2015 Polyamines, regulated by ornithine decarboxylase (ODC) modulate eIF-5A which is a direct regulator of the LIN28/Let-7 axis. Polyamines 0-10 ornithine decarboxylase 1 Homo sapiens 50-53 25415050-4 2015 Polyamines, regulated by ornithine decarboxylase (ODC) modulate eIF-5A which is a direct regulator of the LIN28/Let-7 axis. Polyamines 0-10 eukaryotic translation initiation factor 5A Homo sapiens 64-70 25415050-4 2015 Polyamines, regulated by ornithine decarboxylase (ODC) modulate eIF-5A which is a direct regulator of the LIN28/Let-7 axis. Polyamines 0-10 lin-28 homolog A Homo sapiens 106-111 25277523-0 2014 The polyamine catabolic enzyme SAT1 modulates tumorigenesis and radiation response in GBM. Polyamines 4-13 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 31-35 25277523-5 2014 Spermidine/spermine-N1-acetyltransferase 1 (SAT1), an enzyme involved in polyamine catabolism, was identified as a gene that promotes resistance to ionizing radiation (IR), is overexpressed in brain tumors, and correlates with poor outcomes. Polyamines 73-82 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 0-42 25277523-5 2014 Spermidine/spermine-N1-acetyltransferase 1 (SAT1), an enzyme involved in polyamine catabolism, was identified as a gene that promotes resistance to ionizing radiation (IR), is overexpressed in brain tumors, and correlates with poor outcomes. Polyamines 73-82 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 44-48 25318549-1 2014 Ornithine decarboxylase antizyme 1 (OAZ1) is an antizyme targeting ornithine decarboxylase for degradation, subsequently inhibiting polyamine production to prevent cell proliferation. Polyamines 132-141 ornithine decarboxylase antizyme 1 Homo sapiens 0-34 25318549-1 2014 Ornithine decarboxylase antizyme 1 (OAZ1) is an antizyme targeting ornithine decarboxylase for degradation, subsequently inhibiting polyamine production to prevent cell proliferation. Polyamines 132-141 ornithine decarboxylase antizyme 1 Homo sapiens 36-40 25318549-1 2014 Ornithine decarboxylase antizyme 1 (OAZ1) is an antizyme targeting ornithine decarboxylase for degradation, subsequently inhibiting polyamine production to prevent cell proliferation. Polyamines 132-141 ornithine decarboxylase 1 Homo sapiens 67-90 25216923-0 2014 Natural polyamines inhibit the migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pathways. Polyamines 8-18 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 84-87 25216923-0 2014 Natural polyamines inhibit the migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pathways. Polyamines 8-18 nuclear factor of activated T cells 1 Homo sapiens 88-94 25216923-6 2014 Furthermore, the RANKL-mediated activation of the Src-PYK2 signaling axis and of transcription factors such as NF-kappaB and NFATc1 was prevented by each polyamine. Polyamines 154-163 TNF superfamily member 11 Homo sapiens 17-22 25216923-6 2014 Furthermore, the RANKL-mediated activation of the Src-PYK2 signaling axis and of transcription factors such as NF-kappaB and NFATc1 was prevented by each polyamine. Polyamines 154-163 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 50-53 25216923-6 2014 Furthermore, the RANKL-mediated activation of the Src-PYK2 signaling axis and of transcription factors such as NF-kappaB and NFATc1 was prevented by each polyamine. Polyamines 154-163 protein tyrosine kinase 2 beta Homo sapiens 54-58 25216923-6 2014 Furthermore, the RANKL-mediated activation of the Src-PYK2 signaling axis and of transcription factors such as NF-kappaB and NFATc1 was prevented by each polyamine. Polyamines 154-163 nuclear factor of activated T cells 1 Homo sapiens 125-131 25216923-7 2014 Anti-osteoclastogenic and anti-migration activities of polyamines were confirmed by evaluating their potential to downregulate the mRNA expression levels of osteoclastogenesis-related genes such as OSCAR, TRAP, cathepsin K and c-Src, and genes related to fusion and/or migration of preosteoclasts. Polyamines 55-65 cathepsin K Homo sapiens 211-222 25216923-7 2014 Anti-osteoclastogenic and anti-migration activities of polyamines were confirmed by evaluating their potential to downregulate the mRNA expression levels of osteoclastogenesis-related genes such as OSCAR, TRAP, cathepsin K and c-Src, and genes related to fusion and/or migration of preosteoclasts. Polyamines 55-65 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 227-232 25216923-9 2014 In conclusion, polyamines could exhibit anti-osteoclastogenic activity by inhibiting the migration of preosteoclasts via the Ca(2+)-PYK2-Src-NFATc1 signaling axis. Polyamines 15-25 protein tyrosine kinase 2 beta Homo sapiens 132-136 24666424-4 2014 The rate-limiting step in polyamine biosynthesis is catalysed by ornithine decarboxylase (ODC). Polyamines 26-35 ornithine decarboxylase 1 Rattus norvegicus 65-88 25216923-9 2014 In conclusion, polyamines could exhibit anti-osteoclastogenic activity by inhibiting the migration of preosteoclasts via the Ca(2+)-PYK2-Src-NFATc1 signaling axis. Polyamines 15-25 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 137-140 24666424-4 2014 The rate-limiting step in polyamine biosynthesis is catalysed by ornithine decarboxylase (ODC). Polyamines 26-35 ornithine decarboxylase 1 Rattus norvegicus 90-93 25216923-9 2014 In conclusion, polyamines could exhibit anti-osteoclastogenic activity by inhibiting the migration of preosteoclasts via the Ca(2+)-PYK2-Src-NFATc1 signaling axis. Polyamines 15-25 nuclear factor of activated T cells 1 Homo sapiens 141-147 25673551-4 2014 In BV the overgrowth of anaerobes produces noxious substances like polyamines and other compounds that trigger the release of pro-inflammatory cytokines interleukin (IL)-1 beta and IL-8. Polyamines 67-77 C-X-C motif chemokine ligand 8 Homo sapiens 181-185 25278234-4 2014 Analog 5, with a polyamine group incorporated at the P2" thiovaline side chain exhibited antiproliferative activity against the P-gp expressing HCT116/VM46 cell line. Polyamines 17-26 phosphoglycolate phosphatase Homo sapiens 128-132 25426416-0 2014 MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines. Polyamines 99-109 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 0-4 25426416-0 2014 MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines. Polyamines 99-109 transient receptor potential cation channel subfamily M member 7 Homo sapiens 14-19 25426416-9 2014 Overall, this study provides evidence that MycN promotes TRPM7 expression and cell migration through a mechanism that involves ODC synthesis of polyamines. Polyamines 144-154 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 43-47 25426416-9 2014 Overall, this study provides evidence that MycN promotes TRPM7 expression and cell migration through a mechanism that involves ODC synthesis of polyamines. Polyamines 144-154 transient receptor potential cation channel subfamily M member 7 Homo sapiens 57-62 24557991-4 2014 We have explored the effect of the TARP gamma-2 (also known as stargazin) on the inhibitory potency of three structurally different polyamine toxins at Ca(2+)-permeable homomeric GluA1 AMPARs expressed in oocytes. Polyamines 132-141 calcium voltage-gated channel auxiliary subunit gamma 2 Homo sapiens 63-72 25426416-9 2014 Overall, this study provides evidence that MycN promotes TRPM7 expression and cell migration through a mechanism that involves ODC synthesis of polyamines. Polyamines 144-154 ornithine decarboxylase 1 Homo sapiens 127-130 25197950-8 2014 SPR was used to measure the amount of bound polyamines, and when combined with QCM-D, the data indicate that the layer condensation leads to a small release of water from the highly hydrated DNA films. Polyamines 44-54 sepiapterin reductase Homo sapiens 0-3 24557991-0 2014 Inhibition of AMPA receptors by polyamine toxins is regulated by agonist efficacy and stargazin. Polyamines 32-41 calcium voltage-gated channel auxiliary subunit gamma 2 Homo sapiens 86-95 24557991-2 2014 Polyamine toxins derived from spiders and wasps are use- and voltage-dependent channel blockers of Ca(2+)-permeable AMPARs. Polyamines 0-9 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 116-122 25301005-11 2014 Our data show that Cav-1 negatively regulates VSMC polyamine uptake and that the proliferative advantage of Cav-1 KO cells is critically dependent on polyamine uptake. Polyamines 51-60 caveolin 1, caveolae protein Mus musculus 19-24 24557991-5 2014 We find that polyamine toxin IC50 is differentially affected by presence of stargazin depending on the efficacy of the agonists used to activate GluA1. Polyamines 13-22 calcium voltage-gated channel auxiliary subunit gamma 2 Homo sapiens 76-85 25301005-11 2014 Our data show that Cav-1 negatively regulates VSMC polyamine uptake and that the proliferative advantage of Cav-1 KO cells is critically dependent on polyamine uptake. Polyamines 150-159 caveolin 1, caveolae protein Mus musculus 108-113 25301005-12 2014 We provide proof-of-principle for targeting Cav-1-regulated polyamine uptake as a strategy to fight unwanted VSMC proliferation as observed in restenosis. Polyamines 60-69 caveolin 1, caveolae protein Mus musculus 44-49 24557991-5 2014 We find that polyamine toxin IC50 is differentially affected by presence of stargazin depending on the efficacy of the agonists used to activate GluA1. Polyamines 13-22 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 145-150 24557991-6 2014 Co-assembly of GluA1 receptors with stargazin increases the potency of the polyamine toxins when activated by the weak partial agonist kainate, but has no effect in presence of full-agonist L-glutamate (Glu) and partial agonist (RS)-willardiine. Polyamines 75-84 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 15-20 24557991-6 2014 Co-assembly of GluA1 receptors with stargazin increases the potency of the polyamine toxins when activated by the weak partial agonist kainate, but has no effect in presence of full-agonist L-glutamate (Glu) and partial agonist (RS)-willardiine. Polyamines 75-84 calcium voltage-gated channel auxiliary subunit gamma 2 Homo sapiens 36-45 25156824-4 2014 Agmatine, an endogenous polyamine catalyzed from L-arginine by arginine decarboxylase (ADC), is a neuromodulator and it protects neurons/glia against various injuries. Polyamines 24-33 antizyme inhibitor 2 Homo sapiens 63-85 25061098-12 2014 Our data suggest that NOS3 is the key enzyme for NO production by conceptus Tr and that this protein also regulates the availability of arginine in conceptus tissues for synthesis of polyamines that are essential for conceptus survival and development. Polyamines 183-193 nitric oxide synthase 3 Homo sapiens 22-26 25037221-3 2014 Despite the importance of AOC1 in regulating polyamine breakdown, very little is known about the molecular mechanisms that control its expression. Polyamines 45-54 amine oxidase, copper-containing 1 Mus musculus 26-30 25037221-11 2014 These findings suggest that WT1-dependent control of polyamine breakdown, which is mediated by changes in AOC1 expression, has a role in kidney organogenesis. Polyamines 53-62 WT1 transcription factor Mus musculus 28-31 25037221-11 2014 These findings suggest that WT1-dependent control of polyamine breakdown, which is mediated by changes in AOC1 expression, has a role in kidney organogenesis. Polyamines 53-62 amine oxidase, copper-containing 1 Mus musculus 106-110 25156824-4 2014 Agmatine, an endogenous polyamine catalyzed from L-arginine by arginine decarboxylase (ADC), is a neuromodulator and it protects neurons/glia against various injuries. Polyamines 24-33 antizyme inhibitor 2 Homo sapiens 87-90 25164663-0 2014 Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. Polyamines 80-89 TCR gamma alternate reading frame protein Homo sapiens 37-41 25221519-5 2014 Numerous structure-function studies have revealed structural elements of Kir channels that determine their susceptibility to polyamine block, and enable the steep voltage dependence of this process. Polyamines 125-134 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 73-76 25164663-3 2014 TARP-induced modifications in AMPAR channel behavior include increased single-channel conductance and weakened block of calcium-permeable AMPARs (CP-AMPARs) by endogenous intracellular polyamines. Polyamines 185-195 TCR gamma alternate reading frame protein Homo sapiens 0-4 25164663-3 2014 TARP-induced modifications in AMPAR channel behavior include increased single-channel conductance and weakened block of calcium-permeable AMPARs (CP-AMPARs) by endogenous intracellular polyamines. Polyamines 185-195 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 30-35 25164663-3 2014 TARP-induced modifications in AMPAR channel behavior include increased single-channel conductance and weakened block of calcium-permeable AMPARs (CP-AMPARs) by endogenous intracellular polyamines. Polyamines 185-195 glutamate ionotropic receptor AMPA type subunit 1 Homo sapiens 138-144 25164663-6 2014 We found that gamma-2 increased the permeability of several cations but not the estimated AMPAR pore size, suggesting that TARP-induced relief of polyamine block does not reflect altered pore diameter. Polyamines 146-155 TCR gamma alternate reading frame protein Homo sapiens 123-127 25164663-8 2014 We identified the membrane proximal region of the C terminus as crucial for full TARP-attenuation of polyamine block, whereas complete deletion of the C-tail markedly enhanced the TARP-induced increase in channel conductance; thus, the TARP C-tail influences ion permeation. Polyamines 101-110 TCR gamma alternate reading frame protein Homo sapiens 81-85 25221519-8 2014 We also briefly review some of the important and well understood physiological roles of polyamine sensitive, strongly rectifying Kir channels, primarily of the Kir2 family. Polyamines 88-97 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 129-132 24824458-3 2014 However, under physiological conditions which particular polyamine induces AZ1, and thereby ODC activity, is unknown due to their inter-conversion. Polyamines 57-66 ornithine decarboxylase 1 Rattus norvegicus 92-95 24922332-0 2014 Co-immobilized poly(ethylene glycol)-block-polyamines promote sensitivity and restrict biofouling on gold sensor surface for detecting factor IX in human plasma. Polyamines 43-53 coagulation factor IX Homo sapiens 135-144 24922332-1 2014 In order to detect an extremely low amount of human coagulation factor IX (FIX), poly(ethylene glycol) (PEG)/aptamer co-immobilized surface was constructed using original PEG-polyamine surface modification agents on surface plasmon resonance (SPR) sensor chip. Polyamines 175-184 coagulation factor IX Homo sapiens 52-73 25140796-1 2014 Ornithine decarboxylase (ODC) catalyzes the decarboxylation of ornithine to putrescine and is the rate-limiting enzyme in the polyamine biosynthesis pathway. Polyamines 126-135 ornithine decarboxylase 1 Homo sapiens 0-23 25140796-1 2014 Ornithine decarboxylase (ODC) catalyzes the decarboxylation of ornithine to putrescine and is the rate-limiting enzyme in the polyamine biosynthesis pathway. Polyamines 126-135 ornithine decarboxylase 1 Homo sapiens 25-28 24854736-1 2014 SMO (spermine oxidase) and APAO (acetylpolyamine oxidase) are flavoenzymes that play a critical role in the catabolism of polyamines. Polyamines 122-132 spermine oxidase Homo sapiens 0-3 24854736-1 2014 SMO (spermine oxidase) and APAO (acetylpolyamine oxidase) are flavoenzymes that play a critical role in the catabolism of polyamines. Polyamines 122-132 spermine oxidase Homo sapiens 5-21 24983675-7 2014 Environmental cells, such as fibroblasts and adipocytes, serve as food donors for cancer cells, which reject waste products (CO2 , H+, ammoniac, polyamines...) promoting EMT, invasion, angiogenesis and proliferation. Polyamines 145-155 IL2 inducible T cell kinase Homo sapiens 170-173 25338399-11 2014 The XPS of AC-EDA before and after Pb(II) adsorption showed that the polyamine group was involved in the adsorption, and should be a main factor of the high efficient adsorption. Polyamines 69-78 ectodysplasin A Homo sapiens 14-17 24824458-9 2014 Surprisingly, addition of DENSpm along with DFMO restored AZ1 induction by putrescine in polyamine-depleted cells suggesting that the increased SSAT activity in response to DENSpm converted SPM to SPD, leading to the expression of AZ1. Polyamines 89-98 spermidine/spermine N1-acetyl transferase 1 Rattus norvegicus 144-148 24793417-5 2014 Gliadin treatment increases, indeed, the expression and the activity of arginase, leading to the production of polyamines through the subsequent induction of ornithine decarboxylase. Polyamines 111-121 ornithine decarboxylase 1 Homo sapiens 158-181 24836671-5 2014 Most notably, BoHV-6 encoded the first herpesviral protein (Bov2.b2) similar to cellular ornithine decarboxylase, an enzyme that catalyses the first and rate-limiting step in the biosynthesis of polyamines. Polyamines 195-205 Bov2 Bovine gammaherpesvirus 6 60-64 24836671-5 2014 Most notably, BoHV-6 encoded the first herpesviral protein (Bov2.b2) similar to cellular ornithine decarboxylase, an enzyme that catalyses the first and rate-limiting step in the biosynthesis of polyamines. Polyamines 195-205 ornithine decarboxylase Bovine gammaherpesvirus 6 89-112 24605920-0 2014 Overexpression of S-adenosyl-L-methionine synthetase increased tomato tolerance to alkali stress through polyamine metabolism. Polyamines 105-114 S-adenosylmethionine synthase 3 Solanum lycopersicum 18-52 24605920-1 2014 S-adenosyl-L-methionine (SAM) synthetase is the key enzyme involved in the biosynthesis of SAM, which serves as a common precursor for polyamines (PAs) and ethylene. Polyamines 135-145 S-adenosylmethionine synthase 3 Solanum lycopersicum 0-40 24605920-1 2014 S-adenosyl-L-methionine (SAM) synthetase is the key enzyme involved in the biosynthesis of SAM, which serves as a common precursor for polyamines (PAs) and ethylene. Polyamines 147-150 S-adenosylmethionine synthase 3 Solanum lycopersicum 0-40 25338399-11 2014 The XPS of AC-EDA before and after Pb(II) adsorption showed that the polyamine group was involved in the adsorption, and should be a main factor of the high efficient adsorption. Polyamines 69-78 submaxillary gland androgen regulated protein 3B Homo sapiens 35-41 24867251-0 2014 Synthetic polyamine BPA-C8 inhibits TGF-beta1-mediated conversion of human dermal fibroblast to myofibroblasts and establishment of galectin-1-rich extracellular matrix in vitro. Polyamines 10-19 transforming growth factor beta 1 Homo sapiens 36-45 24867251-0 2014 Synthetic polyamine BPA-C8 inhibits TGF-beta1-mediated conversion of human dermal fibroblast to myofibroblasts and establishment of galectin-1-rich extracellular matrix in vitro. Polyamines 10-19 galectin 1 Homo sapiens 132-142 24607957-2 2014 Spermidine/spermine N(1)-acetyltransferase (SSAT), which regulates intracellular levels of polyamines by catabolizing spermidine and spermine, has a controversial role in the development of cancers. Polyamines 91-101 spermidine/spermine N1-acetyl transferase 1 Mus musculus 0-42 24599794-3 2014 We show that YAP1 overexpression stimulated the expression of the TPO1 gene encoding a polyamine efflux pump, and that Yap1 failed to rescue the imp2Delta mutant from bleomycin toxicity in the absence of the TPO1 gene. Polyamines 87-96 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 13-17 24607957-3 2014 In this study, the polyamine metabolism and function of SSAT were characterized in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and acute lymphoid leukemia patient samples. Polyamines 19-28 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 56-60 24627544-7 2014 Use of MAO-SLC7A1 knockdown in conceptuses decreased arginine transport (73%, P<0.01), the abundance of ornithine decarboxylase, and nitric oxide synthase (NOS3) proteins, arginine-related amino acids [citrulline (76%, P<0.05) and ornithine (40%, P<0.05)], and polyamines, which likely accounts for their retarded development. Polyamines 270-280 solute carrier family 7 member 1 Homo sapiens 11-17 24750033-0 2014 Endogenous polyamines reduce the toxicity of soluble abeta peptide aggregates associated with Alzheimer"s disease. Polyamines 11-21 amyloid beta precursor protein Homo sapiens 53-58 24750033-1 2014 Polyamines promote the formation of the Abeta peptide amyloid fibers that are a hallmark of Alzheimer"s disease. Polyamines 0-10 amyloid beta precursor protein Homo sapiens 40-45 24750033-2 2014 Here we show that polyamines interact with nonaggregated Abeta peptides, thereby reducing the peptide"s hydrophobic surface. Polyamines 18-28 amyloid beta precursor protein Homo sapiens 57-62 24967154-1 2014 Ornithine decarboxylase (ODC) is the key enzyme in the polyamine biosynthetic pathway. Polyamines 55-64 ornithine decarboxylase 1 Homo sapiens 0-23 24967154-1 2014 Ornithine decarboxylase (ODC) is the key enzyme in the polyamine biosynthetic pathway. Polyamines 55-64 ornithine decarboxylase 1 Homo sapiens 25-28 24967154-2 2014 ODC levels are controlled by polyamines through the induction of antizymes (AZs), small proteins that inhibit ODC and target it to proteasomal degradation without ubiquitination. Polyamines 29-39 ornithine decarboxylase 1 Homo sapiens 0-3 24967154-2 2014 ODC levels are controlled by polyamines through the induction of antizymes (AZs), small proteins that inhibit ODC and target it to proteasomal degradation without ubiquitination. Polyamines 29-39 ornithine decarboxylase 1 Homo sapiens 110-113 24633404-5 2014 The in-line reaction of polyamines with o-phthalaldehyde and N-acetyl-L-cysteine yields fluorescent derivatives which are separated on a reversed-phase C18 column and detected by a fluorometer at an excitation wavelength of 340 nm and an emission wavelength of 450 nm. Polyamines 24-34 Bardet-Biedl syndrome 9 Homo sapiens 152-155 24633404-8 2014 The assays are linear between 1 and 50 muM for each of the polyamines. Polyamines 59-69 latexin Homo sapiens 39-42 25019617-0 2014 Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2. Polyamines 61-70 solute carrier family 22 member 2 Homo sapiens 103-131 25019617-1 2014 Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2. Polyamines 0-9 solute carrier family 22 member 2 Homo sapiens 81-109 25019617-1 2014 Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2. Polyamines 0-9 solute carrier family 22 member 2 Homo sapiens 111-116 24636142-0 2014 In vitro leishmanicidal activity of pyrazole-containing polyamine macrocycles which inhibit the Fe-SOD enzyme of Leishmania infantum and Leishmania braziliensis species. Polyamines 56-65 superoxide dismutase 1 Homo sapiens 99-102 24877669-8 2014 These results suggest that maintaining polyamine biosynthesis through the enhanced SAMDC activity in grapevine leaf tissues under salt stress conditions could contribute to the enhanced ROS scavenging activity and a protection of photosynthetic apparatus from oxidative damages. Polyamines 39-48 S-adenosylmethionine decarboxylase proenzyme Vitis vinifera 83-88 24824658-3 2014 Here, we investigate the effect of both N-methylation and N-hydroxylation of spider polyamine toxins by the synthesis and biological evaluation of the naturally occurring N-methylated argiopinines and pseudoargiopinines I and II, N-hydroxylated Agel-489 and Agel-505, as well as N-methylated analogues of the NMDA and AMPA iGlu receptor subtype selective antagonists ArgTX-93 and ArgTX-48. Polyamines 84-93 gelsolin Homo sapiens 245-249 24824658-3 2014 Here, we investigate the effect of both N-methylation and N-hydroxylation of spider polyamine toxins by the synthesis and biological evaluation of the naturally occurring N-methylated argiopinines and pseudoargiopinines I and II, N-hydroxylated Agel-489 and Agel-505, as well as N-methylated analogues of the NMDA and AMPA iGlu receptor subtype selective antagonists ArgTX-93 and ArgTX-48. Polyamines 84-93 gelsolin Homo sapiens 258-262 24921942-3 2014 Polyamines, like spermidine and spermine, are positive modulators of NMDAR function and it has been shown that their levels are regulated by Abeta. Polyamines 0-10 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 69-74 24921942-4 2014 In this study we show here that interruption of NMDAR modulation by polyamines through blockade of its binding site at NMDAR by arcaine (0.02 nmol/site), or inhibition of polyamine synthesis by DFMO (2.7 nmol/site), reverses Abeta25-35-induced memory impairment in mice in a novel object recognition task. Polyamines 68-78 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 48-53 24921942-4 2014 In this study we show here that interruption of NMDAR modulation by polyamines through blockade of its binding site at NMDAR by arcaine (0.02 nmol/site), or inhibition of polyamine synthesis by DFMO (2.7 nmol/site), reverses Abeta25-35-induced memory impairment in mice in a novel object recognition task. Polyamines 68-78 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 119-124 24921942-4 2014 In this study we show here that interruption of NMDAR modulation by polyamines through blockade of its binding site at NMDAR by arcaine (0.02 nmol/site), or inhibition of polyamine synthesis by DFMO (2.7 nmol/site), reverses Abeta25-35-induced memory impairment in mice in a novel object recognition task. Polyamines 68-77 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 48-53 24921942-4 2014 In this study we show here that interruption of NMDAR modulation by polyamines through blockade of its binding site at NMDAR by arcaine (0.02 nmol/site), or inhibition of polyamine synthesis by DFMO (2.7 nmol/site), reverses Abeta25-35-induced memory impairment in mice in a novel object recognition task. Polyamines 68-77 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 119-124 24921942-6 2014 The Abeta-induced nuclear translocation of Jacob was blocked upon application of traxoprodil (4 nM), arcaine (4 microM) or DFMO (5 microM), suggesting that activation of the polyamine binding site at NMDAR located probably at extrasynaptic sites might underlie the cognitive deficits of Abeta25-35-treated mice. Polyamines 174-183 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 200-205 24921942-10 2014 Taken together these data provide evidence that polyamine modulation of extrasynaptic NMDAR signaling might be involved in Abeta pathology. Polyamines 48-57 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 86-91 24607957-2 2014 Spermidine/spermine N(1)-acetyltransferase (SSAT), which regulates intracellular levels of polyamines by catabolizing spermidine and spermine, has a controversial role in the development of cancers. Polyamines 91-101 spermidine/spermine N1-acetyl transferase 1 Mus musculus 44-48 24589373-7 2014 NO and PAs significantly upregulated ion transporters such as the plasma membrane Na(+)/H(+) antiporter (SlSOS1), vacuolar Na(+)/H(+) exchanger (SlNHX1 and SlNHX2), and Na(+) transporter and signal components including ROS, MAPK, and Ca(2+) signal pathways, as well as several transcription factors. Polyamines 7-10 plasmalemma Na+/H+ antiporter Solanum lycopersicum 105-111 24589373-7 2014 NO and PAs significantly upregulated ion transporters such as the plasma membrane Na(+)/H(+) antiporter (SlSOS1), vacuolar Na(+)/H(+) exchanger (SlNHX1 and SlNHX2), and Na(+) transporter and signal components including ROS, MAPK, and Ca(2+) signal pathways, as well as several transcription factors. Polyamines 7-10 Na+/H+ antiporter Solanum lycopersicum 145-151 24589373-7 2014 NO and PAs significantly upregulated ion transporters such as the plasma membrane Na(+)/H(+) antiporter (SlSOS1), vacuolar Na(+)/H(+) exchanger (SlNHX1 and SlNHX2), and Na(+) transporter and signal components including ROS, MAPK, and Ca(2+) signal pathways, as well as several transcription factors. Polyamines 7-10 Na+/H+ antiporter 2 Solanum lycopersicum 156-162 24566173-0 2014 Agp2p, the plasma membrane transregulator of polyamine uptake, regulates the antifungal activities of the plant defensin NaD1 and other cationic peptides. Polyamines 45-54 Agp2p Saccharomyces cerevisiae S288C 0-5 24634478-1 2014 Polyamine oxidase (PAO), which requires FAD as a cofactor, functions in polyamine catabolism. Polyamines 72-81 polyamine oxidase 1 Zea mays 19-22 24735382-8 2014 DISCUSSION AND CONCLUSION: Gender differences in the regulation of SSAT1 gene expression may possibly be due to gender-specific effects of stress, ethanol toxicity, and/or polyamines levels. Polyamines 172-182 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 67-72 24566173-0 2014 Agp2p, the plasma membrane transregulator of polyamine uptake, regulates the antifungal activities of the plant defensin NaD1 and other cationic peptides. Polyamines 45-54 guanine nucleotide-binding protein subunit beta Saccharomyces cerevisiae S288C 121-125 24566173-6 2014 Agp2p is a plasma membrane protein that regulates the transport of polyamines and other molecules, many of which carry a positive charge. Polyamines 67-77 Agp2p Saccharomyces cerevisiae S288C 0-5 24566173-8 2014 Agp2p senses and regulates the uptake of the polyamine spermidine, and competitive inhibition of the antifungal activity of NaD1 by spermidine was observed in both S. cerevisiae and the plant pathogen Fusarium oxysporum. Polyamines 45-54 Agp2p Saccharomyces cerevisiae S288C 0-5 24566173-8 2014 Agp2p senses and regulates the uptake of the polyamine spermidine, and competitive inhibition of the antifungal activity of NaD1 by spermidine was observed in both S. cerevisiae and the plant pathogen Fusarium oxysporum. Polyamines 45-54 guanine nucleotide-binding protein subunit beta Saccharomyces cerevisiae S288C 124-128 24636909-12 2014 Take together, PtsrMYB plays a positive role in dehydration tolerance, which may be, at least in part, due to the modulation of polyamine synthesis by regulating the ADC gene. Polyamines 128-137 arginine decarboxylase Nicotiana tabacum 166-169 24464033-0 2014 Akt and Erk1/2 activate the ornithine decarboxylase/polyamine system in cardioprotective ischemic preconditioning in rats: the role of mitochondrial permeability transition pores. Polyamines 52-61 AKT serine/threonine kinase 1 Rattus norvegicus 0-3 24464033-0 2014 Akt and Erk1/2 activate the ornithine decarboxylase/polyamine system in cardioprotective ischemic preconditioning in rats: the role of mitochondrial permeability transition pores. Polyamines 52-61 mitogen activated protein kinase 3 Rattus norvegicus 8-14 24464033-0 2014 Akt and Erk1/2 activate the ornithine decarboxylase/polyamine system in cardioprotective ischemic preconditioning in rats: the role of mitochondrial permeability transition pores. Polyamines 52-61 ornithine decarboxylase 1 Rattus norvegicus 28-51 24464033-1 2014 Ornithine decarboxylase (ODC) is the first rate-limiting enzyme in polyamine biosynthesis, which is essential for cell survival. Polyamines 67-76 ornithine decarboxylase 1 Rattus norvegicus 0-23 24464033-1 2014 Ornithine decarboxylase (ODC) is the first rate-limiting enzyme in polyamine biosynthesis, which is essential for cell survival. Polyamines 67-76 ornithine decarboxylase 1 Rattus norvegicus 25-28 24464033-2 2014 We hypothesized that the ODC/polyamine system is involved in ischemic preconditioning (IPC)-mediated cardioprotection through the activation of Erk1/2 and Akt and through the inhibition of the mitochondrial permeability transition (mPT). Polyamines 29-38 ornithine decarboxylase 1 Rattus norvegicus 25-28 24464033-2 2014 We hypothesized that the ODC/polyamine system is involved in ischemic preconditioning (IPC)-mediated cardioprotection through the activation of Erk1/2 and Akt and through the inhibition of the mitochondrial permeability transition (mPT). Polyamines 29-38 mitogen activated protein kinase 3 Rattus norvegicus 144-150 24464033-2 2014 We hypothesized that the ODC/polyamine system is involved in ischemic preconditioning (IPC)-mediated cardioprotection through the activation of Erk1/2 and Akt and through the inhibition of the mitochondrial permeability transition (mPT). Polyamines 29-38 AKT serine/threonine kinase 1 Rattus norvegicus 155-158 24464033-4 2014 IPC significantly upregulated the ODC/polyamine pathway, promoted Erk1/2 and Akt phosphorylation, and reduced the infarct size and heart dysfunction after reperfusion. Polyamines 38-47 ornithine decarboxylase 1 Rattus norvegicus 34-37 24464033-6 2014 Moreover, the inhibition of the IPC-induced activation of Erk1/2 and Akt using PD98059 or wortmannin downregulated the ODC/polyamine system. Polyamines 123-132 mitogen activated protein kinase 3 Rattus norvegicus 58-64 24464033-6 2014 Moreover, the inhibition of the IPC-induced activation of Erk1/2 and Akt using PD98059 or wortmannin downregulated the ODC/polyamine system. Polyamines 123-132 AKT serine/threonine kinase 1 Rattus norvegicus 69-72 24464033-6 2014 Moreover, the inhibition of the IPC-induced activation of Erk1/2 and Akt using PD98059 or wortmannin downregulated the ODC/polyamine system. Polyamines 123-132 ornithine decarboxylase 1 Rattus norvegicus 119-122 24464033-9 2014 These results suggest that IPC upregulates the ODC/polyamine system and mediates preconditioning cardioprotection, which may depend on the phosphorylation/activation of Erk1/2 and Akt and on the inhibition of the mPT during reperfusion. Polyamines 51-60 ornithine decarboxylase 1 Rattus norvegicus 47-50 24464033-9 2014 These results suggest that IPC upregulates the ODC/polyamine system and mediates preconditioning cardioprotection, which may depend on the phosphorylation/activation of Erk1/2 and Akt and on the inhibition of the mPT during reperfusion. Polyamines 51-60 mitogen activated protein kinase 3 Rattus norvegicus 169-175 24721803-16 2014 A human lipocalin-2 mutant with cysteine 87 replaced by alanine (C87A) contained less polyamines and exhibited a reduced capacity to form heterodimeric complexes with MMP9. Polyamines 86-96 lipocalin 2 Homo sapiens 8-19 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 105-128 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 130-133 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 spermidine/spermine N1-acetyl transferase 1 Mus musculus 139-181 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 spermidine/spermine N1-acetyl transferase 1 Mus musculus 183-187 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 spermidine/spermine N1-acetyl transferase 1 Mus musculus 200-204 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 polyamine oxidase (exo-N4-amino) Mus musculus 213-230 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 polyamine oxidase (exo-N4-amino) Mus musculus 232-235 24717514-11 2014 Direct evidence for increased polyamine flux resulting from NNMT inhibition includes elevated urinary excretion and adipocyte secretion of diacetylspermine, a product of polyamine metabolism. Polyamines 30-39 nicotinamide N-methyltransferase Mus musculus 60-64 24717514-11 2014 Direct evidence for increased polyamine flux resulting from NNMT inhibition includes elevated urinary excretion and adipocyte secretion of diacetylspermine, a product of polyamine metabolism. Polyamines 170-179 nicotinamide N-methyltransferase Mus musculus 60-64 24717514-13 2014 Thus, NNMT is a novel regulator of histone methylation, polyamine flux and NAD(+)-dependent SIRT1 signalling, and is a unique and attractive target for treating obesity and type 2 diabetes. Polyamines 56-65 nicotinamide N-methyltransferase Mus musculus 6-10 24765099-6 2014 Here we explore the role of peroxisomal PA backconversion and in particular that catalyzed by the highly expressed AtPAO3 in the regulation of ROS homeostasis and mitochondrial respiratory burst. Polyamines 40-42 polyamine oxidase 3 Arabidopsis thaliana 115-121 24305501-7 2014 Among pathways that were differentially responsive to testosterone in prostate, we identified ornithine decarboxylase (Odc1), an enzyme in polyamine biosynthesis, as a testosterone-responsive gene that is unresponsive to rFst. Polyamines 139-148 ornithine decarboxylase, structural 1 Mus musculus 94-117 24305501-7 2014 Among pathways that were differentially responsive to testosterone in prostate, we identified ornithine decarboxylase (Odc1), an enzyme in polyamine biosynthesis, as a testosterone-responsive gene that is unresponsive to rFst. Polyamines 139-148 ornithine decarboxylase, structural 1 Mus musculus 119-123 23999450-10 2014 Finally, ArgI promoted aortic vascular smooth muscle cell proliferation, which was associated with increased production of intracellular polyamines. Polyamines 137-147 arginase, liver Mus musculus 9-13 24565893-4 2014 LPS up regulated the genes involved in polyamine turnover; ODC (ornithine decarboxylase), SSAT (spermidine/spermine-N1-acetyltransferase) and SAMdc (S-adenosyl methionine decarboxylase) in head kidney cells when co cultured with liver cells. Polyamines 39-48 ornithine decarboxylase Salmo salar 59-62 24565893-4 2014 LPS up regulated the genes involved in polyamine turnover; ODC (ornithine decarboxylase), SSAT (spermidine/spermine-N1-acetyltransferase) and SAMdc (S-adenosyl methionine decarboxylase) in head kidney cells when co cultured with liver cells. Polyamines 39-48 ornithine decarboxylase Salmo salar 64-87 24550437-5 2014 It is also shown that AtPAO5 oxidizes the polyamines spermine, thermospermine, and N(1)-acetylspermine, the latter being the best in vitro substrate of the recombinant enzyme. Polyamines 42-52 polyamine oxidase 5 Arabidopsis thaliana 22-28 24550437-6 2014 AtPAO5 also oxidizes these polyamines in vivo, as was evidenced by analysis of polyamine levels in the 35S::AtPAO5-6His Arabidopsis transgenic plants, as well as in a loss-of-function atpao5 mutant. Polyamines 27-37 polyamine oxidase 5 Arabidopsis thaliana 0-6 24550437-6 2014 AtPAO5 also oxidizes these polyamines in vivo, as was evidenced by analysis of polyamine levels in the 35S::AtPAO5-6His Arabidopsis transgenic plants, as well as in a loss-of-function atpao5 mutant. Polyamines 27-36 polyamine oxidase 5 Arabidopsis thaliana 0-6 24550437-8 2014 Positive regulation of AtPAO5 expression by polyamines at the transcriptional and post-transcriptional level is also shown. Polyamines 44-54 polyamine oxidase 5 Arabidopsis thaliana 23-29 24567191-5 2014 SlZF2 enhanced salt sensitivity in Arabidopsis, whereas SlZF2 delayed senescence and improved tomato salt tolerance, particularly by maintaining photosynthesis and increasing polyamine biosynthesis, in salt-treated hydroponic cultures (125 mm sodium chloride, 20 d). Polyamines 175-184 ZF2 protein Solanum lycopersicum 56-61 24615811-0 2014 Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines. Polyamines 85-95 X-linked inhibitor of apoptosis Homo sapiens 17-21 24615811-0 2014 Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines. Polyamines 85-95 ELAV like RNA binding protein 1 Homo sapiens 59-62 24567191-7 2014 Transcriptome analysis of 35S::SlZF2 revealed that SlZF2 both increased and reduced expression of a comparable number of genes involved in various physiological processes such as photosynthesis, polyamine biosynthesis, and hormone (notably ABA) biosynthesis/signaling. Polyamines 195-204 ZF2 protein Solanum lycopersicum 51-56 23508577-0 2014 The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines. Polyamines 70-79 cadherin 1 Homo sapiens 49-59 24648395-0 2014 Arginine decarboxylase and agmatinase: an alternative pathway for de novo biosynthesis of polyamines for development of mammalian conceptuses. Polyamines 90-100 antizyme inhibitor 2 Homo sapiens 0-22 24648395-0 2014 Arginine decarboxylase and agmatinase: an alternative pathway for de novo biosynthesis of polyamines for development of mammalian conceptuses. Polyamines 90-100 agmatinase Homo sapiens 27-37 24648395-1 2014 Ornithine decarboxylase (ODC1) is considered the rate-controlling enzyme for the classical de novo biosynthesis of polyamines (putrescine, spermidine, and spermine) in mammals. Polyamines 115-125 ornithine decarboxylase 1 Homo sapiens 0-23 24648395-1 2014 Ornithine decarboxylase (ODC1) is considered the rate-controlling enzyme for the classical de novo biosynthesis of polyamines (putrescine, spermidine, and spermine) in mammals. Polyamines 115-125 ornithine decarboxylase 1 Homo sapiens 25-29 24648395-2 2014 However, metabolism of arginine to agmatine via arginine decarboxylase (ADC) and conversion of agmatine to polyamines via agmatinase (AGMAT) is an alternative pathway long recognized in lower organisms, but only recently suggested for neurons and liver cells of mammals. Polyamines 107-117 agmatinase Homo sapiens 122-132 24648395-2 2014 However, metabolism of arginine to agmatine via arginine decarboxylase (ADC) and conversion of agmatine to polyamines via agmatinase (AGMAT) is an alternative pathway long recognized in lower organisms, but only recently suggested for neurons and liver cells of mammals. Polyamines 107-117 agmatinase Homo sapiens 134-139 24648395-3 2014 We now provide evidence for a functional ADC/AGMAT pathway for the synthesis of polyamines in mammalian reproductive tissue for embryonic survival and development. Polyamines 80-90 agmatinase Homo sapiens 45-50 24648395-4 2014 We first investigated cellular functions of polyamines by in vivo knockdown of translation of mRNA for ODC1 in ovine conceptus trophectoderm using morpholino antisense oligonucleotides (MAOs) and found that one-half of the conceptuses were morphologically and functionally either normal or abnormal. Polyamines 44-54 ornithine decarboxylase 1 Homo sapiens 103-107 24648395-5 2014 Furthermore, we found that increases in ADC/AGMAT mRNA levels and in the translation of AGMAT mRNA among conceptuses in MAO-ODC1 knockdown compensated for the loss of ODC1, supporting polyamine synthesis from arginine and accounting for the normal and abnormal phenotypes of conceptuses. Polyamines 184-193 agmatinase Homo sapiens 88-93 24648395-5 2014 Furthermore, we found that increases in ADC/AGMAT mRNA levels and in the translation of AGMAT mRNA among conceptuses in MAO-ODC1 knockdown compensated for the loss of ODC1, supporting polyamine synthesis from arginine and accounting for the normal and abnormal phenotypes of conceptuses. Polyamines 184-193 ornithine decarboxylase 1 Homo sapiens 124-128 24648395-5 2014 Furthermore, we found that increases in ADC/AGMAT mRNA levels and in the translation of AGMAT mRNA among conceptuses in MAO-ODC1 knockdown compensated for the loss of ODC1, supporting polyamine synthesis from arginine and accounting for the normal and abnormal phenotypes of conceptuses. Polyamines 184-193 ornithine decarboxylase 1 Homo sapiens 167-171 24648395-6 2014 We conclude that the majority of polyamine synthesis is by the conventional ODC1-dependent pathway (arginine-ornithine-putrescine) and that deficiencies in ODC1 result in increased activity of the rescue ADC/AGMAT-dependent pathway (arginine-agmatine-putrescine) for production of polyamines. Polyamines 33-42 ornithine decarboxylase 1 Homo sapiens 76-80 24648395-6 2014 We conclude that the majority of polyamine synthesis is by the conventional ODC1-dependent pathway (arginine-ornithine-putrescine) and that deficiencies in ODC1 result in increased activity of the rescue ADC/AGMAT-dependent pathway (arginine-agmatine-putrescine) for production of polyamines. Polyamines 33-42 ornithine decarboxylase 1 Homo sapiens 156-160 24648395-6 2014 We conclude that the majority of polyamine synthesis is by the conventional ODC1-dependent pathway (arginine-ornithine-putrescine) and that deficiencies in ODC1 result in increased activity of the rescue ADC/AGMAT-dependent pathway (arginine-agmatine-putrescine) for production of polyamines. Polyamines 33-42 agmatinase Homo sapiens 208-213 24648395-6 2014 We conclude that the majority of polyamine synthesis is by the conventional ODC1-dependent pathway (arginine-ornithine-putrescine) and that deficiencies in ODC1 result in increased activity of the rescue ADC/AGMAT-dependent pathway (arginine-agmatine-putrescine) for production of polyamines. Polyamines 281-291 ornithine decarboxylase 1 Homo sapiens 156-160 24648395-6 2014 We conclude that the majority of polyamine synthesis is by the conventional ODC1-dependent pathway (arginine-ornithine-putrescine) and that deficiencies in ODC1 result in increased activity of the rescue ADC/AGMAT-dependent pathway (arginine-agmatine-putrescine) for production of polyamines. Polyamines 281-291 agmatinase Homo sapiens 208-213 23851697-11 2014 Preliminary data from our laboratory have revealed that SLC22A1 might be involved in the PA uptake; in addition to one member of ABC superfamily (MDR1 protein) might also mediate the efflux of polyamine like molecules. Polyamines 89-91 solute carrier family 22 member 1 Homo sapiens 56-63 23851697-11 2014 Preliminary data from our laboratory have revealed that SLC22A1 might be involved in the PA uptake; in addition to one member of ABC superfamily (MDR1 protein) might also mediate the efflux of polyamine like molecules. Polyamines 89-91 ATP binding cassette subfamily B member 1 Homo sapiens 146-150 23851697-11 2014 Preliminary data from our laboratory have revealed that SLC22A1 might be involved in the PA uptake; in addition to one member of ABC superfamily (MDR1 protein) might also mediate the efflux of polyamine like molecules. Polyamines 193-202 solute carrier family 22 member 1 Homo sapiens 56-63 23851697-11 2014 Preliminary data from our laboratory have revealed that SLC22A1 might be involved in the PA uptake; in addition to one member of ABC superfamily (MDR1 protein) might also mediate the efflux of polyamine like molecules. Polyamines 193-202 ATP binding cassette subfamily B member 1 Homo sapiens 146-150 23508577-0 2014 The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines. Polyamines 70-79 lysine demethylase 1A Homo sapiens 89-118 23881108-2 2014 Our data, in conjunction with other studies, suggest an unexpected role for the polyamine catabolic enzyme spermidine/spermine-N1-acetyltransferase (SSAT) in fat homeostasis. Polyamines 80-89 spermidine/spermine N1-acetyl transferase 1 Mus musculus 149-153 23508577-0 2014 The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines. Polyamines 70-79 lysine demethylase 1A Homo sapiens 120-124 23881108-7 2014 Adipose-specific SSAT knockout mice and global SSAT knockout mice on a high-fat diet exhibited similar growth curves and proteomic patterns in their WAT, confirming that attenuated consumption of acetyl-CoA in acetylation of polyamines in adipose tissue drives the obese phenotype of these mice. Polyamines 225-235 spermidine/spermine N1-acetyl transferase 1 Mus musculus 17-21 23508577-6 2014 In this study, we examined the effects of the polyamine analogue LSD1 inhibitor 2d (1,15-bis{N (5)-[3,3-(diphenyl)propyl]-N(1)-biguanido}-4,12-diazapentadecane) in human acute myeloid leukemia (AML) cell lines. Polyamines 46-55 lysine demethylase 1A Homo sapiens 65-69 23508577-11 2014 As hematologic malignancies have demonstrated promising clinical responses to agents targeting epigenetic silencing, this polyamine analogue LSD1 inhibitor presents an exciting new avenue for the development of novel therapeutic agents for the treatment of AML. Polyamines 122-131 lysine demethylase 1A Homo sapiens 141-145 23884694-1 2014 Elevated expression of ornithine decarboxylase (ODC), the regulatory enzyme in polyamine biosynthesis, targeted to the epidermis is sufficient to promote skin tumor development following a single subthreshold dose of dimethylbenz(a)anthracene (DMBA). Polyamines 79-88 ornithine decarboxylase, structural 1 Mus musculus 23-46 23771789-8 2014 Consequently, the polyamine catabolic pathway in general and specifically SMO and SSAT provide exciting new targets for chemoprevention and/or chemotherapy. Polyamines 18-27 spermine oxidase Homo sapiens 74-77 23884694-1 2014 Elevated expression of ornithine decarboxylase (ODC), the regulatory enzyme in polyamine biosynthesis, targeted to the epidermis is sufficient to promote skin tumor development following a single subthreshold dose of dimethylbenz(a)anthracene (DMBA). Polyamines 79-88 ornithine decarboxylase, structural 1 Mus musculus 48-51 23884694-4 2014 Because increased ODC activity not only stimulates proliferation but also increases reactive oxygen species (ROS) generation via subsequent induction of polyamine catabolic oxidases, we used an inhibitor of polyamine catabolic oxidase activity, MDL72527, to investigate whether ROS generation by polyamine catabolic oxidases contributes to skin tumorigenesis in DMBA-initiated ODC-ER transgenic skin. Polyamines 153-162 ornithine decarboxylase, structural 1 Mus musculus 18-21 23771789-8 2014 Consequently, the polyamine catabolic pathway in general and specifically SMO and SSAT provide exciting new targets for chemoprevention and/or chemotherapy. Polyamines 18-27 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 82-86 23904095-2 2014 Polyamines are also required for optimal mucosal growth, and the inhibition of ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, blocks growth. Polyamines 144-153 ornithine decarboxylase 1 Homo sapiens 79-102 23836421-1 2014 Spermidine/spermine N(1)-acetyltransferase (SSAT) regulates intracellular polyamine levels by catabolizing spermidine and spermine which are essential for cell proliferation and differentiation. Polyamines 74-83 spermidine/spermine N1-acetyl transferase 1 Mus musculus 0-42 23904095-2 2014 Polyamines are also required for optimal mucosal growth, and the inhibition of ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, blocks growth. Polyamines 144-153 ornithine decarboxylase 1 Homo sapiens 104-107 23904095-5 2014 ODC activity is inhibited by antizyme-1 (AZ) whose synthesis is stimulated by polyamines, thus, providing a negative feedback regulation of the enzyme. Polyamines 78-88 ornithine decarboxylase 1 Homo sapiens 0-3 23904095-5 2014 ODC activity is inhibited by antizyme-1 (AZ) whose synthesis is stimulated by polyamines, thus, providing a negative feedback regulation of the enzyme. Polyamines 78-88 ornithine decarboxylase antizyme 1 Homo sapiens 29-39 23836421-1 2014 Spermidine/spermine N(1)-acetyltransferase (SSAT) regulates intracellular polyamine levels by catabolizing spermidine and spermine which are essential for cell proliferation and differentiation. Polyamines 74-83 spermidine/spermine N1-acetyl transferase 1 Mus musculus 44-48 23904095-5 2014 ODC activity is inhibited by antizyme-1 (AZ) whose synthesis is stimulated by polyamines, thus, providing a negative feedback regulation of the enzyme. Polyamines 78-88 ornithine decarboxylase antizyme 1 Homo sapiens 41-43 23836421-7 2014 The data suggest that SSAT overexpression and the concomitantly accelerated polyamine metabolism in hematopoietic cells and bone marrow microenvironment affect lineage commitment and lead to the development of a mouse myeloproliferative disease in SSAT mice. Polyamines 76-85 spermidine/spermine N1-acetyl transferase 1 Mus musculus 248-252 23904095-13 2014 The question remaining to be answered is whether AZ inhibits growth directly or whether it acts by decreasing the availability of polyamines to the dividing cells. Polyamines 130-140 ornithine decarboxylase antizyme 1 Homo sapiens 49-51 23963538-11 2014 In our study, we aimed to investigate the mechanism of apoptotic cell death induced by EBR, related with polyamine biosynthetic and catabolic pathways in LNCaP (AR+), DU145 (AR-) prostate cancer cell lines and PNT1a normal prostate epithelial cell line. Polyamines 105-114 androgen receptor Homo sapiens 161-163 23963538-11 2014 In our study, we aimed to investigate the mechanism of apoptotic cell death induced by EBR, related with polyamine biosynthetic and catabolic pathways in LNCaP (AR+), DU145 (AR-) prostate cancer cell lines and PNT1a normal prostate epithelial cell line. Polyamines 105-114 androgen receptor Homo sapiens 174-176 23846959-2 2014 Recent studies have shown that polyamines, which are essential for mRNA translation, cellular replication, and the formation of the hypusine modification of eIF5A may play an important role in the progression of cellular inflammation. Polyamines 31-41 eukaryotic translation initiation factor 5A Mus musculus 157-162 24077669-0 2014 Multiple forms of mouse antizyme inhibitor 1 mRNA differentially regulated by polyamines. Polyamines 78-88 antizyme inhibitor 1 Homo sapiens 24-44 24077669-1 2014 Antizyme inhibitor 1 (Azin1), a positive regulator of cellular polyamines, is induced by various proliferative stimuli and repressed by polyamines. Polyamines 63-73 antizyme inhibitor 1 Homo sapiens 0-20 24248311-7 2014 Besides several growth factors, PRP also contains polyamines in the micromolar range, which may also exert an anti-apoptotic effect, thus helping to explain the efficacy of PRP in enhancing osteogenesis in vitro and in vivo. Polyamines 50-60 complement component 4 binding protein alpha Homo sapiens 32-35 24077669-1 2014 Antizyme inhibitor 1 (Azin1), a positive regulator of cellular polyamines, is induced by various proliferative stimuli and repressed by polyamines. Polyamines 63-73 antizyme inhibitor 1 Homo sapiens 22-27 24077669-1 2014 Antizyme inhibitor 1 (Azin1), a positive regulator of cellular polyamines, is induced by various proliferative stimuli and repressed by polyamines. Polyamines 136-146 antizyme inhibitor 1 Homo sapiens 0-20 24077669-1 2014 Antizyme inhibitor 1 (Azin1), a positive regulator of cellular polyamines, is induced by various proliferative stimuli and repressed by polyamines. Polyamines 136-146 antizyme inhibitor 1 Homo sapiens 22-27 24077669-2 2014 It has been reported that the translational repression of Azin1 by polyamines involves an upstream open reading frame on the mRNA, but little has been known about polyamine effect on its transcription or splicing. Polyamines 67-77 antizyme inhibitor 1 Homo sapiens 58-63 24077669-2 2014 It has been reported that the translational repression of Azin1 by polyamines involves an upstream open reading frame on the mRNA, but little has been known about polyamine effect on its transcription or splicing. Polyamines 67-76 antizyme inhibitor 1 Homo sapiens 58-63 24077669-6 2014 Thus, polyamines regulate two novel steps of Azin1 expression, namely the transcription and a particular splicing pattern, both of which may affect the level of mRNA encoding the full-length active Azin1 protein. Polyamines 6-16 antizyme inhibitor 1 Homo sapiens 45-50 24077669-6 2014 Thus, polyamines regulate two novel steps of Azin1 expression, namely the transcription and a particular splicing pattern, both of which may affect the level of mRNA encoding the full-length active Azin1 protein. Polyamines 6-16 antizyme inhibitor 1 Homo sapiens 198-203 24248311-7 2014 Besides several growth factors, PRP also contains polyamines in the micromolar range, which may also exert an anti-apoptotic effect, thus helping to explain the efficacy of PRP in enhancing osteogenesis in vitro and in vivo. Polyamines 50-60 complement component 4 binding protein alpha Homo sapiens 173-176 24253595-8 2014 Polyamine depleted cells had higher levels of MKP-1 protein and decreased JNK1/2 activity and apoptosis. Polyamines 0-9 dual specificity phosphatase 1 Rattus norvegicus 46-51 24253595-15 2014 Thus, MEK/ERK activity controls the levels of MKP-1 and, thereby, regulates JNK activity in polyamine-depleted cells. Polyamines 92-101 Eph receptor B1 Rattus norvegicus 10-13 24242917-3 2014 Previous studies from our group have shown that polyamine-depletion of intestinal epithelial cells (IEC-6) decreases cyclin-dependent kinase 2 (Cdk2) activity, increases p53 and p21Cip1 protein levels, induces G1 arrest, and protects cells from camptothecin (CPT)-induced apoptosis. Polyamines 48-57 cyclin dependent kinase 2 Rattus norvegicus 117-142 24253595-15 2014 Thus, MEK/ERK activity controls the levels of MKP-1 and, thereby, regulates JNK activity in polyamine-depleted cells. Polyamines 92-101 dual specificity phosphatase 1 Rattus norvegicus 46-51 24242917-3 2014 Previous studies from our group have shown that polyamine-depletion of intestinal epithelial cells (IEC-6) decreases cyclin-dependent kinase 2 (Cdk2) activity, increases p53 and p21Cip1 protein levels, induces G1 arrest, and protects cells from camptothecin (CPT)-induced apoptosis. Polyamines 48-57 cyclin dependent kinase 2 Rattus norvegicus 144-148 24253595-15 2014 Thus, MEK/ERK activity controls the levels of MKP-1 and, thereby, regulates JNK activity in polyamine-depleted cells. Polyamines 92-101 mitogen-activated protein kinase 8 Rattus norvegicus 76-79 24242917-3 2014 Previous studies from our group have shown that polyamine-depletion of intestinal epithelial cells (IEC-6) decreases cyclin-dependent kinase 2 (Cdk2) activity, increases p53 and p21Cip1 protein levels, induces G1 arrest, and protects cells from camptothecin (CPT)-induced apoptosis. Polyamines 48-57 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 170-173 24778323-3 2014 A polyamine-blocking therapy (PBT) that combines the well-characterized ornithine decarboxylase (ODC) inhibitor difluoromethylornithine (DFMO) with AMXT 1501, a novel inhibitor of the polyamine transport system, blocked tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells. Polyamines 2-11 ornithine decarboxylase, structural 1 Mus musculus 72-95 24253595-0 2014 The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis. Polyamines 65-74 Eph receptor B1 Rattus norvegicus 27-30 24253595-0 2014 The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis. Polyamines 65-74 mitogen-activated protein kinase 8 Rattus norvegicus 41-44 24253595-0 2014 The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis. Polyamines 65-74 mitogen activated protein kinase 14 Rattus norvegicus 49-52 24253595-1 2014 Polyamine-depletion inhibited apoptosis by activating ERK1/2, while, preventing JNK1/2 activation. Polyamines 0-9 mitogen activated protein kinase 3 Rattus norvegicus 54-60 24253595-3 2014 Therefore, we predicted that polyamines might regulate MKP1 via MEK/ERK and thereby apoptosis. Polyamines 29-39 dual specificity phosphatase 1 Rattus norvegicus 55-59 24253595-3 2014 Therefore, we predicted that polyamines might regulate MKP1 via MEK/ERK and thereby apoptosis. Polyamines 29-39 Eph receptor B1 Rattus norvegicus 68-71 24236849-9 2014 The Enoph1 gene, which is involved in polyamine biosynthesis, is differently expressed in parental strains, which have different brain spermidine levels and show distinct anxiety and depression-related phenotype. Polyamines 38-47 enolase-phosphatase 1 Mus musculus 4-10 23889994-6 2014 In chloroplast structure, thylakoid proteins linked to polyamines belong mainly to antenna proteins of light-harvesting chlorophyll a/b-protein complexes. Polyamines 55-65 tyrosinase related protein 1 Homo sapiens 134-143 24096079-1 2014 Ornithine decarboxylase (ODC) is the sentinel enzyme in polyamine biosynthesis. Polyamines 56-65 ornithine decarboxylase 1 Homo sapiens 0-23 24417867-12 2014 (3) The Kv1.1 mRNA and protein expression were significantly increased by AMK treatment in control and polyamine-deficient IEC-6 cells. Polyamines 103-112 potassium voltage-gated channel subfamily A member 1 Rattus norvegicus 8-13 24417867-13 2014 CONCLUSIONS: The results of our current studies revealed that treatment with AMK significantly stimulates the migration of intestinal epithelial cells through polyamine-Kv1.1 channel signaling pathway, which could promote the healing of intestinal injury. Polyamines 159-168 potassium voltage-gated channel subfamily A member 1 Rattus norvegicus 169-174 24556690-0 2014 Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism. Polyamines 101-110 arginase 2 Homo sapiens 0-10 24112028-4 2014 The expression of PA biosynthesis (ADC, SAMDC, SPDS and SPMS) and catabolism (DAO and PAO) genes was systematically up-regulated by PAs. Polyamines 18-20 adenosylmethionine decarboxylase 1 Homo sapiens 40-45 25786620-7 2014 In addition, these polyamines dramatically reduced the total number of leukocytes, suggesting an immune suppression mechanism, while cationic liposomes, which also increased liver enzymes levels in the serum, elevated the total number of leukocytes probably by activation of Toll-like receptors 2 and 4. Polyamines 19-29 toll-like receptor 2 Mus musculus 275-302 23737330-0 2014 Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells. Polyamines 0-10 lin-28 homolog A Homo sapiens 49-54 23737330-4 2014 We report that multiple non-coding RNAs are altered by polyamine depletion including induction of microRNA (miRNA) let-7i, a member of the tumor suppressive let-7 family. Polyamines 55-64 microRNA let-7i Homo sapiens 98-121 23737330-6 2014 Depletion of polyamines using difluoromethylornithine (DFMO) or genetic knockdown of the polyamine-modified eukaryotic translation initiation factor 5A isoforms 1 and 2 (eIF5A1/2) resulted in robust reduction of both HMGA2 and LIN28. Polyamines 13-23 eukaryotic translation initiation factor 5A Homo sapiens 170-178 23737330-6 2014 Depletion of polyamines using difluoromethylornithine (DFMO) or genetic knockdown of the polyamine-modified eukaryotic translation initiation factor 5A isoforms 1 and 2 (eIF5A1/2) resulted in robust reduction of both HMGA2 and LIN28. Polyamines 13-23 high mobility group AT-hook 2 Homo sapiens 217-222 23737330-6 2014 Depletion of polyamines using difluoromethylornithine (DFMO) or genetic knockdown of the polyamine-modified eukaryotic translation initiation factor 5A isoforms 1 and 2 (eIF5A1/2) resulted in robust reduction of both HMGA2 and LIN28. Polyamines 13-23 lin-28 homolog A Homo sapiens 227-232 23737330-6 2014 Depletion of polyamines using difluoromethylornithine (DFMO) or genetic knockdown of the polyamine-modified eukaryotic translation initiation factor 5A isoforms 1 and 2 (eIF5A1/2) resulted in robust reduction of both HMGA2 and LIN28. Polyamines 13-22 eukaryotic translation initiation factor 5A Homo sapiens 170-178 23737330-8 2014 Our findings suggest that polyamines are oncometabolites that influence specific aspects of tumorigenesis by regulating pluripotency associated factors, such as LIN28, via an eIF5A-dependent but let-7-independent mechanism while the expression of proliferation-related genes regulated by let-7, such as HMGA2, is mediated through microRNA mediated repression. Polyamines 26-36 lin-28 homolog A Homo sapiens 161-166 23737330-8 2014 Our findings suggest that polyamines are oncometabolites that influence specific aspects of tumorigenesis by regulating pluripotency associated factors, such as LIN28, via an eIF5A-dependent but let-7-independent mechanism while the expression of proliferation-related genes regulated by let-7, such as HMGA2, is mediated through microRNA mediated repression. Polyamines 26-36 eukaryotic translation initiation factor 5A Homo sapiens 175-180 23737330-8 2014 Our findings suggest that polyamines are oncometabolites that influence specific aspects of tumorigenesis by regulating pluripotency associated factors, such as LIN28, via an eIF5A-dependent but let-7-independent mechanism while the expression of proliferation-related genes regulated by let-7, such as HMGA2, is mediated through microRNA mediated repression. Polyamines 26-36 high mobility group AT-hook 2 Homo sapiens 303-308 23737330-9 2014 Therefore, manipulating polyamine metabolism may be a novel method of targeting the LIN28/let-7 pathway in specific disease states. Polyamines 24-33 lin-28 homolog A Homo sapiens 84-89 24287136-6 2014 Restricted occurrence of the MPO subfamily in Nicotiana and Solanum indicates that, during the formation of the Solanaceae, MPO has evolved from a DAO, which functions in polyamine catabolism within peroxisomes, by optimizing substrate preference and gene expression patterns to be suitable for alkaloid formation. Polyamines 171-180 copper methylamine oxidase-like Nicotiana tabacum 29-32 24287136-6 2014 Restricted occurrence of the MPO subfamily in Nicotiana and Solanum indicates that, during the formation of the Solanaceae, MPO has evolved from a DAO, which functions in polyamine catabolism within peroxisomes, by optimizing substrate preference and gene expression patterns to be suitable for alkaloid formation. Polyamines 171-180 copper methylamine oxidase-like Nicotiana tabacum 124-127 24096079-1 2014 Ornithine decarboxylase (ODC) is the sentinel enzyme in polyamine biosynthesis. Polyamines 56-65 ornithine decarboxylase 1 Homo sapiens 25-28 24494193-3 2014 According to the catalytic properties of TG2, protein cross-linking, polyamine conjugation, and/or deamidation are potential post-translational modifications. Polyamines 69-78 transglutaminase 2 Homo sapiens 41-44 24494193-4 2014 In this article, we have demonstrated that TG2 catalyzes either polyamine conjugation or deamidation to GlxI depending on the presence of polyamines or not. Polyamines 64-73 transglutaminase 2 Homo sapiens 43-46 24494193-4 2014 In this article, we have demonstrated that TG2 catalyzes either polyamine conjugation or deamidation to GlxI depending on the presence of polyamines or not. Polyamines 138-148 transglutaminase 2 Homo sapiens 43-46 25664996-0 2014 Synthetic polyamines: new compounds specific to actin dynamics for mammalian cell and fission yeast. Polyamines 10-20 actin Saccharomyces cerevisiae S288C 48-53 24174210-7 2014 However, antizyme 1 overexpression caused only minor changes in tissue polyamine levels demonstrating the challenges in using the "antizyme approach" to deplete polyamines in a living animal. Polyamines 71-80 ornithine decarboxylase antizyme 1 Mus musculus 9-19 24174210-7 2014 However, antizyme 1 overexpression caused only minor changes in tissue polyamine levels demonstrating the challenges in using the "antizyme approach" to deplete polyamines in a living animal. Polyamines 161-171 ornithine decarboxylase antizyme 1 Mus musculus 9-19 23684952-4 2014 These are Rpn4, a transcriptional regulator of proteasome homeostasis, thymidylate synthase, an enzyme required for production of DNA precursors and ornithine decarboxylase, the initial enzyme committed to polyamine biosynthesis. Polyamines 206-215 proteasome 26S subunit, non-ATPase 9 Homo sapiens 10-14 25664996-6 2014 We have found that synthetic, cell permeant, short polyamines are promising new actin regulators in this context. Polyamines 51-61 actin Saccharomyces cerevisiae S288C 80-85 23684952-4 2014 These are Rpn4, a transcriptional regulator of proteasome homeostasis, thymidylate synthase, an enzyme required for production of DNA precursors and ornithine decarboxylase, the initial enzyme committed to polyamine biosynthesis. Polyamines 206-215 thymidylate synthetase Homo sapiens 71-91 25664996-10 2014 Thus, synthetic polyamines appear to be potentially powerful agents in a quantitative approach to the role of actin in complex processes in cell biology, developmental biology and potentially cancer research. Polyamines 16-26 actin Saccharomyces cerevisiae S288C 110-115 23684952-4 2014 These are Rpn4, a transcriptional regulator of proteasome homeostasis, thymidylate synthase, an enzyme required for production of DNA precursors and ornithine decarboxylase, the initial enzyme committed to polyamine biosynthesis. Polyamines 206-215 ornithine decarboxylase 1 Homo sapiens 149-172 25162012-6 2014 Notably, polyamines 1-5 were submicromolar inhibitors of the cancer drug target CA IX, this is more potent than either spermine or spermidine. Polyamines 9-19 carbonic anhydrase 9 Homo sapiens 80-85 25893137-1 2014 OBJECTIVES: Spermidine/spermine-N1-acetytransferase (SSAT) is the key enzyme in the catabolism of polyamines that are involved in regulating NMDA functioning. Polyamines 98-108 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 12-51 24649071-4 2014 Putrescine, spermidine and spermine are natural polyamines that are catabolized by a specific enzyme, spermidine/spermine acetyltransferase (SSAT). Polyamines 48-58 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 102-139 24649071-4 2014 Putrescine, spermidine and spermine are natural polyamines that are catabolized by a specific enzyme, spermidine/spermine acetyltransferase (SSAT). Polyamines 48-58 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 141-145 24649071-5 2014 The single-nucleotide polymorphisms (SNPs) in the intron region of ODC (+316 G>A) and promoter region of SSAT (-1415 T>C) genes have been found to be associated with the polyamines expression levels. Polyamines 176-186 ornithine decarboxylase 1 Homo sapiens 67-70 24649071-5 2014 The single-nucleotide polymorphisms (SNPs) in the intron region of ODC (+316 G>A) and promoter region of SSAT (-1415 T>C) genes have been found to be associated with the polyamines expression levels. Polyamines 176-186 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 108-112 24251576-4 2014 Herein, we examine the biosynthetic pathway of T(SH)2, identifying three key points that are susceptible to attack pharmacologically: the activity of the trypanothione reductase (TR), the function of glutamate-cysteine ligase (GCL) and polyamine transport in T. cruzi. Polyamines 236-245 threonine synthase like 2 Homo sapiens 47-53 23701543-0 2014 CDK inhibitors induce mitochondria-mediated apoptosis through the activation of polyamine catabolic pathway in LNCaP, DU145 and PC3 prostate cancer cells. Polyamines 80-89 chromobox 8 Homo sapiens 128-131 23701543-13 2014 Similarly to classical chemotherapeutic agents, both drugs could up-regulate polyamine catabolic enzymes (SSAT, SMO and PAO) in cell type dependent manner. Polyamines 77-86 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 106-110 23701543-13 2014 Similarly to classical chemotherapeutic agents, both drugs could up-regulate polyamine catabolic enzymes (SSAT, SMO and PAO) in cell type dependent manner. Polyamines 77-86 smoothened, frizzled class receptor Homo sapiens 112-115 23701549-1 2014 Spermidine/spermine-N1-acetyltransferase (SSAT) is a mitochondrial-localized enzyme that is highly inducible and tightly controlled and is the rate-limiting enzyme in polyamine catabolism. Polyamines 167-176 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 0-40 23701549-1 2014 Spermidine/spermine-N1-acetyltransferase (SSAT) is a mitochondrial-localized enzyme that is highly inducible and tightly controlled and is the rate-limiting enzyme in polyamine catabolism. Polyamines 167-176 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 42-46 23701549-2 2014 It is known that SSAT is induced when polyamine level increases. Polyamines 38-47 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 17-21 23701549-5 2014 Besides polyamines and their analogs, certain stimuli can increase SSAT levels, suggesting that the development of reporters for high throughput screening can lead to the identification of novel pharmacophores that can modulate SSAT translation. Polyamines 8-18 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 228-232 25893137-1 2014 OBJECTIVES: Spermidine/spermine-N1-acetytransferase (SSAT) is the key enzyme in the catabolism of polyamines that are involved in regulating NMDA functioning. Polyamines 98-108 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 53-57 25893137-8 2014 RESULTS: Activation of the polyamine catabolic enzyme, SSAT increases polyamine flux in brain and CSF of HIV infected individuals with HIV-associated neurocognitive disorders. Polyamines 27-36 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 55-59 25893137-8 2014 RESULTS: Activation of the polyamine catabolic enzyme, SSAT increases polyamine flux in brain and CSF of HIV infected individuals with HIV-associated neurocognitive disorders. Polyamines 70-79 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 55-59 24070167-5 2014 The results suggest that 9-anilinoacridine-polyamine derivatives can be employed as effective P-gp modulators. Polyamines 43-52 phosphoglycolate phosphatase Homo sapiens 94-98 23934013-4 2014 PA pretreatment resulted in a distinct reduction of the injury index, and this effect was reflected by a lower stress-evoked LOX activity increase and lipid peroxide levels at the end of the stress period. Polyamines 0-2 probable linoleate 9S-lipoxygenase 5-like Cucumis sativus 125-128 23934013-6 2014 The presented results suggest that exogenous PAs are able to alleviate water deficit-induced membrane permeability and diminish LOX activity. Polyamines 45-48 probable linoleate 9S-lipoxygenase 5-like Cucumis sativus 128-131 24190492-5 2014 Especially induction of polyamine catabolic enzymes spermidine/spermine N1-acetyltransferase (SSAT), polyamine oxidase (PAO) and spermine oxidase (SMO) induced toxic by-products in correlation with the induction of apoptosis in cancer cells. Polyamines 24-33 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 52-92 24190492-5 2014 Especially induction of polyamine catabolic enzymes spermidine/spermine N1-acetyltransferase (SSAT), polyamine oxidase (PAO) and spermine oxidase (SMO) induced toxic by-products in correlation with the induction of apoptosis in cancer cells. Polyamines 24-33 polyamine oxidase Homo sapiens 101-118 24190492-5 2014 Especially induction of polyamine catabolic enzymes spermidine/spermine N1-acetyltransferase (SSAT), polyamine oxidase (PAO) and spermine oxidase (SMO) induced toxic by-products in correlation with the induction of apoptosis in cancer cells. Polyamines 24-33 polyamine oxidase Homo sapiens 120-123 24190492-5 2014 Especially induction of polyamine catabolic enzymes spermidine/spermine N1-acetyltransferase (SSAT), polyamine oxidase (PAO) and spermine oxidase (SMO) induced toxic by-products in correlation with the induction of apoptosis in cancer cells. Polyamines 24-33 spermine oxidase Homo sapiens 129-145 24190492-5 2014 Especially induction of polyamine catabolic enzymes spermidine/spermine N1-acetyltransferase (SSAT), polyamine oxidase (PAO) and spermine oxidase (SMO) induced toxic by-products in correlation with the induction of apoptosis in cancer cells. Polyamines 24-33 spermine oxidase Homo sapiens 147-150 25763711-1 2014 POLYAMINE OXIDASE 1 (OsPAO1), from rice (Oryza sativa), and POLYAMINE OXIDASE 5 (AtPAO5), from Arabidopsis (Arabidopsis thaliana), are enzymes sharing high identity at the amino acid level and with similar characteristics, such as polyamine specificity and pH preference; furthermore, both proteins localize to the cytosol. Polyamines 231-240 polyamine oxidase 5 Arabidopsis thaliana 60-79 24435979-6 2014 Our data suggest that AtPAO2 uORF regulatory mechanism is modulated by polyamines. Polyamines 71-81 polyamine oxidase 2 Arabidopsis thaliana 22-28 25404991-3 2014 Exercise training reduces the incidence of age-related cardiovascular disease and upregulates the ornithine decarboxylase (ODC)/polyamine pathway. Polyamines 128-137 ornithine decarboxylase 1 Rattus norvegicus 98-121 25404991-3 2014 Exercise training reduces the incidence of age-related cardiovascular disease and upregulates the ornithine decarboxylase (ODC)/polyamine pathway. Polyamines 128-137 ornithine decarboxylase 1 Rattus norvegicus 123-126 25404991-8 2014 Exercise training inhibited the loss of preconditioning protection and restored the polyamine pool by activating ODC and inhibiting SSAT in aged hearts. Polyamines 84-93 ornithine decarboxylase 1 Rattus norvegicus 113-116 24492485-2 2014 Here we show that plant CGI-58 also interacts with spermidine synthase 1 (SPDS1), an enzyme that plays a central role in polyamine metabolism by converting putrescine into spermidine. Polyamines 121-130 spermidine synthase Homo sapiens 51-72 24492485-2 2014 Here we show that plant CGI-58 also interacts with spermidine synthase 1 (SPDS1), an enzyme that plays a central role in polyamine metabolism by converting putrescine into spermidine. Polyamines 121-130 spermidine synthase Homo sapiens 74-79 24492485-5 2014 Taken together, the data support a model whereby CGI-58 and PXA1 contribute to the regulation of polyamine metabolism at the transcriptional level, perhaps through a shared lipid-signaling pathway, and that CGI-58 also acts independently of PXA1 to increase spermidine content at a post-transcriptional level, possibly through protein-protein interaction with SPDS1. Polyamines 97-106 peroxisomal ABC transporter 1 Arabidopsis thaliana 60-64 24274257-8 2013 Furthermore, the levels of three polyamines (Ac-SPM, DAc-SPD, and DAc-SPM) were significantly higher only in the relapsed patients. Polyamines 33-43 arylacetamide deacetylase Homo sapiens 53-56