PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15049834-5	2004	The Thz ring, protecting both the amino and thiol groups in Nin-Cys, completely avoids the formylation and Thz side reactions found during hydrofluoric acid (HF) cleavage when N-pi-benzyloxymethyl histidine groups are present.	Thiazolidines	4-7	ninein	Homo sapiens	60-63
15049834-5	2004	The Thz ring, protecting both the amino and thiol groups in Nin-Cys, completely avoids the formylation and Thz side reactions found during hydrofluoric acid (HF) cleavage when N-pi-benzyloxymethyl histidine groups are present.	Thiazolidines	107-110	ninein	Homo sapiens	60-63
14646148-0	2004	Protein splicing of yeast VMA1-derived endonuclease via thiazolidine intermediates.	Thiazolidines	56-68	H(+)-transporting V1 sector ATPase subunit A	Saccharomyces cerevisiae S288C	26-30
11824563-5	2002	These terpenoids and thiazolidine type of antidiabetic agents such as Ciglitazone, although structurally unrelated, share many biological activities: both induce adipose conversion, activate peroxisome proliferator-activated receptor gamma (PPAR gamma) in vitro, and reduce hyperglycemia in animal models of NIDDM.	Thiazolidines	21-33	peroxisome proliferator activated receptor gamma	Mus musculus	191-239
14521714-9	2003	The thiazolidine class of drugs are powerful PPARgamma ligands.	Thiazolidines	4-16	peroxisome proliferator activated receptor gamma	Homo sapiens	45-54
11884132-0	2002	Protein-splicing reaction via a thiazolidine intermediate: crystal structure of the VMA1-derived endonuclease bearing the N and C-terminal propeptides.	Thiazolidines	32-44	H(+)-transporting V1 sector ATPase subunit A	Saccharomyces cerevisiae S288C	84-88
11824563-5	2002	These terpenoids and thiazolidine type of antidiabetic agents such as Ciglitazone, although structurally unrelated, share many biological activities: both induce adipose conversion, activate peroxisome proliferator-activated receptor gamma (PPAR gamma) in vitro, and reduce hyperglycemia in animal models of NIDDM.	Thiazolidines	21-33	peroxisome proliferator activated receptor gamma	Mus musculus	241-251
11462985-5	2001	Our model peptide, the pseudosubstrate sequence of protein kinase C-zeta (PKC-zeta), was associated to the pentapeptide Gly-Arg-Gly-Arg-Lys(Pam)-NH2 through thiazolidine, thioether, disulfide, or hydrazone linkages.	Thiazolidines	157-169	protein kinase C zeta	Homo sapiens	51-72
11462985-5	2001	Our model peptide, the pseudosubstrate sequence of protein kinase C-zeta (PKC-zeta), was associated to the pentapeptide Gly-Arg-Gly-Arg-Lys(Pam)-NH2 through thiazolidine, thioether, disulfide, or hydrazone linkages.	Thiazolidines	157-169	protein kinase C zeta	Homo sapiens	74-82
11462985-5	2001	Our model peptide, the pseudosubstrate sequence of protein kinase C-zeta (PKC-zeta), was associated to the pentapeptide Gly-Arg-Gly-Arg-Lys(Pam)-NH2 through thiazolidine, thioether, disulfide, or hydrazone linkages.	Thiazolidines	157-169	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	140-143
9396157-4	1997	The effects of a retinoid antagonist (LE540) and synergists (retinoid X receptor (RXR) agonists, HX600 or HX630) on the activities of thiazolidine derivatives indicate that these compounds elicit their activities through the nuclear retinoic acid receptors (RARs).	Thiazolidines	134-146	retinoid X receptor alpha	Homo sapiens	61-80
10052967-3	1999	The bicyclic thiazolidine related angiotensin II analogues synthesized exhibited no affinity for the angiotensin II AT1 receptor.	Thiazolidines	13-25	angiotensinogen	Homo sapiens	34-48
9396157-4	1997	The effects of a retinoid antagonist (LE540) and synergists (retinoid X receptor (RXR) agonists, HX600 or HX630) on the activities of thiazolidine derivatives indicate that these compounds elicit their activities through the nuclear retinoic acid receptors (RARs).	Thiazolidines	134-146	retinoid X receptor alpha	Homo sapiens	82-85
9396157-5	1997	All the thiazolidines examined also inhibited IL-1 alpha-induced IL-6 production with IC50 values of 10 nM order.	Thiazolidines	8-21	interleukin 1 alpha	Homo sapiens	46-56
9396157-5	1997	All the thiazolidines examined also inhibited IL-1 alpha-induced IL-6 production with IC50 values of 10 nM order.	Thiazolidines	8-21	interleukin 6	Homo sapiens	65-69
34244238-3	2021	Accordingly, obese patients with cardiovascular disease have better prognoses relative to leaner patients with the same diagnoses, whereas treatment of T2DM patients with thiazolidines, one of the popular insulin sensitizer drugs, significantly increases the risk of heart failure.	Thiazolidines	171-184	insulin	Homo sapiens	205-212
11173569-5	1995	Our study on protein synthesis in primary hepatocyte suspension culture showed that cell injury induced by CCl4 could be reduced in the presence of this thiazolidine compound.	Thiazolidines	153-165	C-C motif chemokine ligand 4	Rattus norvegicus	107-111
8004696-0	1994	Synthesis and evaluation of novel thiazolidine derivatives as thromboxane A2 receptor antagonists.	Thiazolidines	34-46	TBXA2R	Oryctolagus cuniculus	62-85
8879150-10	1996	Three 14C-labelled metabolites (formed by oxidation of imidazoline ring and/or opening of thiazolidine ring) in the milk were isolated and identified.	Thiazolidines	90-102	Weaning weight-maternal milk	Bos taurus	116-120
7535776-0	1995	Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities.	Thiazolidines	0-12	insulin	Homo sapiens	57-64
7535776-1	1995	The mechanisms for the insulin resistance induced by hyperglycemia were investigated by studying the effect of high glucose concentration (HG) and its modulation by thiazolidine derivatives, on insulin signaling using Rat 1 fibroblasts expressing human insulin receptors (HIRc).	Thiazolidines	165-177	insulin	Homo sapiens	23-30
7535776-1	1995	The mechanisms for the insulin resistance induced by hyperglycemia were investigated by studying the effect of high glucose concentration (HG) and its modulation by thiazolidine derivatives, on insulin signaling using Rat 1 fibroblasts expressing human insulin receptors (HIRc).	Thiazolidines	165-177	insulin	Homo sapiens	194-201
7535776-1	1995	The mechanisms for the insulin resistance induced by hyperglycemia were investigated by studying the effect of high glucose concentration (HG) and its modulation by thiazolidine derivatives, on insulin signaling using Rat 1 fibroblasts expressing human insulin receptors (HIRc).	Thiazolidines	165-177	insulin	Homo sapiens	194-201
7535776-11	1995	Finally, HG cells had impaired insulin-stimulated alpha-amino-isobutyric acid uptake, which was ameliorated by exposure to thiazolidine derivatives.	Thiazolidines	123-135	insulin	Homo sapiens	31-38
1701026-4	1990	Quantitative hapten inhibition studies employed to identify IgE-binding regions on the penicillin molecules revealed a heterogeneous group of allergenic determinants consisting exclusively, or in part, of the alpha-aminobenzyl and benzyl side chain groups and the beta-lactam and thiazolidine rings of the penicillin nucleus.	Thiazolidines	280-292	immunoglobulin heavy constant epsilon	Homo sapiens	60-63
34244238-9	2021	Accordingly, obese patients with cardiovascular disease have better prognoses relative to leaner patients with the same diagnoses, whereas treatment of T2DM patients with thiazolidines, one of the popular insulin sensitizer drugs, significantly increases the risk of heart failure.	Thiazolidines	171-184	insulin	Homo sapiens	205-212
2578436-7	1985	Therefore it is concluded that Pen 9 mainly recognizes the thiazolidine ring of penicillin.	Thiazolidines	59-71	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	31-34
35532095-2	2022	EGFR inhibitors targeting the L858R/T790M/C797S mutation bearing thiazolidine-4-one scaffold were discovered, optimized, synthesized, and biologically evaluated.	Thiazolidines	65-77	epidermal growth factor receptor	Homo sapiens	0-4
34985906-5	2022	Here we describe rationally designed bicyclic thiazolidine inhibitors that exhibit superb selectivity and picomolar inhibition of human OGA.	Thiazolidines	46-58	O-GlcNAcase	Homo sapiens	136-139
35455425-0	2022	Dual PI3K/Akt Inhibitors Bearing Coumarin-Thiazolidine Pharmacophores as Potential Apoptosis Inducers in MCF-7 Cells.	Thiazolidines	42-54	AKT serine/threonine kinase 1	Homo sapiens	10-13
3071531-0	1988	Thiazolidine derivatives as potent inhibitors specific for prolyl endopeptidase.	Thiazolidines	0-12	prolyl endopeptidase	Bos taurus	59-79
6708958-4	1984	From these results, it was concluded that benzyl and amidomethyl at C-2, the D-configuration at C-4, and dimethyl at C-5 on the thiazolidine ring have a significant effect on the PCA reaction.	Thiazolidines	128-140	complement C2	Rattus norvegicus	68-71
6708958-4	1984	From these results, it was concluded that benzyl and amidomethyl at C-2, the D-configuration at C-4, and dimethyl at C-5 on the thiazolidine ring have a significant effect on the PCA reaction.	Thiazolidines	128-140	complement C4A	Rattus norvegicus	96-99
6708958-4	1984	From these results, it was concluded that benzyl and amidomethyl at C-2, the D-configuration at C-4, and dimethyl at C-5 on the thiazolidine ring have a significant effect on the PCA reaction.	Thiazolidines	128-140	complement C5	Rattus norvegicus	117-120
32159324-7	2020	A mechanism is proposed in which PRODH catalyzes the oxidation of T2C at the C atom adjacent to the S atom of the thiazolidine ring (C5).	Thiazolidines	114-126	proline dehydrogenase 1	Homo sapiens	33-38
6959113-3	1982	Thus, administration of L-2-oxothiazolidine-4-carboxylate protected against acetaminophen toxicity in mice; the thiazolidine, which is converted to L-cysteine by the enzyme 5-oxo-L-prolinase (present in many animal tissues and in plants) promotes the synthesis of glutathione, which is the actual protectant.	Thiazolidines	31-43	5-oxoprolinase (ATP-hydrolysing)	Mus musculus	173-190
13066-2	1977	D-Pencillamine is believed to inhibit collagen cross-link biosynthesis by forming thiazolidine rings with lysyl-derived aldehydes that are intermediates in bifunctional cross-link synthesis.	Thiazolidines	82-94	collagen type III alpha 1 chain	Gallus gallus	38-46
32887925-3	2020	Herein, we demonstrate that PGRMC1 is required for adipogenesis, and its expression is significantly enhanced by insulin or thiazolidine, an agonist for PPARgamma.	Thiazolidines	124-136	progesterone receptor membrane component 1	Mus musculus	28-34
32887925-3	2020	Herein, we demonstrate that PGRMC1 is required for adipogenesis, and its expression is significantly enhanced by insulin or thiazolidine, an agonist for PPARgamma.	Thiazolidines	124-136	peroxisome proliferator activated receptor gamma	Mus musculus	153-162
885705-3	1977	L-cysteine and analogues are inhibitors of threonine deaminase and it is very likely that the inhibition is due to the formation of a thiazolidine ring with PLP bound to the enzyme.	Thiazolidines	134-146	proteolipid protein 1	Rattus norvegicus	157-160
1011049-2	1976	When a single convulsant dose of DL-PeA was injected, PLP content was decreased, being accompanied with production of PLP-thiazolidine.	Thiazolidines	122-134	proteolipid protein (myelin) 1	Mus musculus	54-57
1011049-2	1976	When a single convulsant dose of DL-PeA was injected, PLP content was decreased, being accompanied with production of PLP-thiazolidine.	Thiazolidines	122-134	proteolipid protein (myelin) 1	Mus musculus	118-121
1095577-5	1975	Analysis of the resolution of D-serine dehydratase by L-and D-cysteine resulted in the establishment of an enzyme bound thiazolidine derivative as an intermediate in the pathway for resolution.	Thiazolidines	120-132	serine racemase	Homo sapiens	30-50
1095577-6	1975	The over-all equilibrium constant (KR) for the reaction, D-serine dehydratase + cystein in equilibrium KR thiazolidine derivative +D-serine apodehydratase was determined.	Thiazolidines	106-118	serine racemase	Homo sapiens	57-77
1095577-8	1975	A value of 7.0 nM for the equilibrium constant for the dissociation of D-serine dehydratase to apoenzyme and free pyridoxal-P was determined from the ratio KR/KT, where KT is the equilibrium constant for the formation of a thiazolidine derivative from free pyridoxal-P and cysteine.	Thiazolidines	223-235	serine racemase	Homo sapiens	71-91
31235913-4	2019	The HMCES DNA-protein cross-link structure provides structural insights into a novel thiazolidine covalent interaction between the DNA abasic site and conserved Cys 2 of HMCES.	Thiazolidines	85-97	5-hydroxymethylcytosine binding, ES cell specific	Homo sapiens	4-9
31872753-9	2020	We observed that the electrochemical decarboxylative methoxylation of oxazolidine and thiazolidine derivatives with the appropriate N-protecting group occurred in a stereospecific manner even though the reaction proceeded through an sp2 planar carbon center.	Thiazolidines	86-98	Sp2 transcription factor	Homo sapiens	233-236
31235913-4	2019	The HMCES DNA-protein cross-link structure provides structural insights into a novel thiazolidine covalent interaction between the DNA abasic site and conserved Cys 2 of HMCES.	Thiazolidines	85-97	5-hydroxymethylcytosine binding, ES cell specific	Homo sapiens	170-175
30278282-0	2019	Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-gamma agonists and anti-inflammatory COX-2 selective inhibitors.	Thiazolidines	65-77	peroxisome proliferator activated receptor gamma	Homo sapiens	142-152
30278282-0	2019	Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-gamma agonists and anti-inflammatory COX-2 selective inhibitors.	Thiazolidines	65-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	184-189
29731503-1	2018	BACKGROUND: The antidiabetic drug teneligliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor with a thiazolidine-specific structure.	Thiazolidines	107-119	dipeptidyl peptidase 4	Homo sapiens	59-81
30351107-3	2018	However, the formation of a thiazolidine ring from NAC at basic pH has not been investigated precisely till date.	Thiazolidines	28-40	X-linked Kx blood group	Homo sapiens	51-54
30351107-7	2018	It is observed that formation of a thiazolidine ring from NAC occurs primarily in four steps, which involve proton abstraction from the thiol (SH) group of NAC and subsequent formation of an S-C bond by a nucleophilic attack of the C-S group on the protonated C-O-H group in NAC.	Thiazolidines	35-47	X-linked Kx blood group	Homo sapiens	58-61
30351107-7	2018	It is observed that formation of a thiazolidine ring from NAC occurs primarily in four steps, which involve proton abstraction from the thiol (SH) group of NAC and subsequent formation of an S-C bond by a nucleophilic attack of the C-S group on the protonated C-O-H group in NAC.	Thiazolidines	35-47	X-linked Kx blood group	Homo sapiens	156-159
30351107-7	2018	It is observed that formation of a thiazolidine ring from NAC occurs primarily in four steps, which involve proton abstraction from the thiol (SH) group of NAC and subsequent formation of an S-C bond by a nucleophilic attack of the C-S group on the protonated C-O-H group in NAC.	Thiazolidines	35-47	X-linked Kx blood group	Homo sapiens	156-159
29635214-0	2018	3D QSAR studies, molecular docking and ADMET evaluation, using thiazolidine derivatives as template to obtain new inhibitors of PIM1 kinase.	Thiazolidines	63-75	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	128-132
29635214-3	2018	In the present paper, a three-dimensional quantitative structure activity relationship (3D-QSAR) and molecular docking were performed to investigate the binding between PIM1 and thiazolidine inhibitors in order to design potent inhibitors.	Thiazolidines	178-190	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	169-173
29635214-12	2018	The results expand our understanding of thiazolidines as inhibitors of PIM1 and could be of great help in lead optimization for early drug discovery of highly potent inhibitors.	Thiazolidines	40-53	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	71-75
29731503-1	2018	BACKGROUND: The antidiabetic drug teneligliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor with a thiazolidine-specific structure.	Thiazolidines	107-119	dipeptidyl peptidase 4	Homo sapiens	83-88
30141927-0	2018	Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).	Thiazolidines	25-37	G protein-coupled bile acid receptor 1	Homo sapiens	50-88
30141927-0	2018	Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).	Thiazolidines	25-37	G protein-coupled bile acid receptor 1	Homo sapiens	90-96
30141927-0	2018	Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).	Thiazolidines	25-37	G protein-coupled bile acid receptor 1	Homo sapiens	98-102
30108464-0	2018	Targeting PPAR-gamma to design and synthesize antidiabetic thiazolidines.	Thiazolidines	59-72	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	10-20
30108464-1	2018	A series of thiazolidine derivatives were designed by docking into PPAR-gamma active site.	Thiazolidines	12-24	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	67-77
28393626-0	2018	In silico modelling and molecular dynamics simulation studies of thiazolidine based PTP1B inhibitors.	Thiazolidines	65-77	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	84-89
28393626-7	2018	The present investigation has identified some of the indispensible structural features of thiazolidine analogues which can further be explored to optimize PTP1B inhibitors.	Thiazolidines	90-102	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	155-160
28459242-5	2017	One unusual oxidation product is the planar NiII-N3S complex [Ni(Lox)] (5; Lox = 2-(5,5-dimethyl-2-(pyridin-2-yl)thiazolidin-3-yl)-N-(2-mercaptoethyl)acetamide), where two-electron oxidation takes place at the substituted thiolate and py-CH2 carbon to generate a thiazolidine heterocycle.	Thiazolidines	263-275	lysyl oxidase	Homo sapiens	65-68
28459242-5	2017	One unusual oxidation product is the planar NiII-N3S complex [Ni(Lox)] (5; Lox = 2-(5,5-dimethyl-2-(pyridin-2-yl)thiazolidin-3-yl)-N-(2-mercaptoethyl)acetamide), where two-electron oxidation takes place at the substituted thiolate and py-CH2 carbon to generate a thiazolidine heterocycle.	Thiazolidines	263-275	lysyl oxidase	Homo sapiens	75-78
27038867-20	2016	Insulin sensitizers like metformin, thiazolidines have also resulted in improvements in cognitive functions, mainly in animal experiments.	Thiazolidines	36-49	insulin	Homo sapiens	0-7
28231521-1	2017	Thiazolidinedione is an important heterocyclic ring system, a pharmacophore and a privileged scaffold in medicinal chemistry; is a derivative of thiazolidine ring which came into existence for its role as antihyperglycemic agent and a specific ligand of PPAR"s (Peroxisome proliferator activated receptor).	Thiazolidines	145-157	peroxisome proliferator activated receptor alpha	Homo sapiens	254-258
27914514-2	2016	Thiazolidines are insulin sensitizers and are used in treating patients with type 2 diabetes.	Thiazolidines	0-13	insulin	Homo sapiens	18-25
28341403-0	2017	Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.	Thiazolidines	0-12	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	67-70
28130183-3	2017	We show that thiazolidine causes sustained activation of the TRPA1 channel and chemically reacts with glutathione, and the chemical reactivity of thiazolidine ring is required for TRPA1 activation.	Thiazolidines	13-25	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	61-66
28130183-3	2017	We show that thiazolidine causes sustained activation of the TRPA1 channel and chemically reacts with glutathione, and the chemical reactivity of thiazolidine ring is required for TRPA1 activation.	Thiazolidines	146-158	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	61-66
28130183-3	2017	We show that thiazolidine causes sustained activation of the TRPA1 channel and chemically reacts with glutathione, and the chemical reactivity of thiazolidine ring is required for TRPA1 activation.	Thiazolidines	146-158	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	180-185
28130183-4	2017	Reducing agents reverse thiazolidine-induced TRPA1 activation, and mutagenesis studies show that nucleophilic cysteine residues in TRPA1 are critical, suggesting an activation mechanism involving thioreactive chemical reactions.	Thiazolidines	24-36	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	45-50
28130183-4	2017	Reducing agents reverse thiazolidine-induced TRPA1 activation, and mutagenesis studies show that nucleophilic cysteine residues in TRPA1 are critical, suggesting an activation mechanism involving thioreactive chemical reactions.	Thiazolidines	24-36	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	131-136
28130183-5	2017	In vivo studies show that thiazolidine induces acute pain and inflammation in mouse and these responses are specifically dependent on TRPA1.	Thiazolidines	26-38	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	134-139
27522482-4	2017	In addition, the aldehyde groups on F-3 react with biothiols (e.g., cysteine, homocysteine) to form thiazolidine diastereomers, which suppress the fluorescence of fluorescein.	Thiazolidines	100-112	coagulation factor III, tissue factor	Homo sapiens	36-39
26871660-4	2016	The most promising compound was the thiazolidine derivative 3, with nanomolar activity for ADAM-10, high selectivity over ADAM-17 and MMPs and good efficacy in reducing the shedding of NKG2D ligands (MIC-B and ULBP3) in three different HL cell lines at non-toxic doses.	Thiazolidines	36-48	ADAM metallopeptidase domain 10	Homo sapiens	91-98
26871660-4	2016	The most promising compound was the thiazolidine derivative 3, with nanomolar activity for ADAM-10, high selectivity over ADAM-17 and MMPs and good efficacy in reducing the shedding of NKG2D ligands (MIC-B and ULBP3) in three different HL cell lines at non-toxic doses.	Thiazolidines	36-48	ADAM metallopeptidase domain 17	Homo sapiens	122-129
26871660-4	2016	The most promising compound was the thiazolidine derivative 3, with nanomolar activity for ADAM-10, high selectivity over ADAM-17 and MMPs and good efficacy in reducing the shedding of NKG2D ligands (MIC-B and ULBP3) in three different HL cell lines at non-toxic doses.	Thiazolidines	36-48	killer cell lectin like receptor K1	Homo sapiens	185-190
26871660-4	2016	The most promising compound was the thiazolidine derivative 3, with nanomolar activity for ADAM-10, high selectivity over ADAM-17 and MMPs and good efficacy in reducing the shedding of NKG2D ligands (MIC-B and ULBP3) in three different HL cell lines at non-toxic doses.	Thiazolidines	36-48	MHC class I polypeptide-related sequence B	Homo sapiens	200-205
26871660-4	2016	The most promising compound was the thiazolidine derivative 3, with nanomolar activity for ADAM-10, high selectivity over ADAM-17 and MMPs and good efficacy in reducing the shedding of NKG2D ligands (MIC-B and ULBP3) in three different HL cell lines at non-toxic doses.	Thiazolidines	36-48	UL16 binding protein 3	Homo sapiens	210-215
21466936-0	2011	Determination of a dipeptidyl peptidase IV agonist, beta-aminoacyl containing thiazolidine derivatives (KR-66223) in rat plasma by liquid chromatography-tandem mass spectrometry.	Thiazolidines	78-90	dipeptidylpeptidase 4	Rattus norvegicus	19-42
23802716-1	2013	Analogues of the previously described spiro[imidazo[1,5-c]thiazole-3,3"-indoline]-2",5,7(6H,7aH)-trione p53 modulators were prepared to explore new structural requirements at the thiazolidine domain for the antiproliferative activity and p53 modulation.	Thiazolidines	179-191	tumor protein p53	Homo sapiens	104-107
23631205-5	2013	In drug therapy of such patients, the drugs to improve insulin resistance, such as biguanides, thiazolidine derivatives, DPP-4 inhibitors and GLP-1 analogues should be selected.	Thiazolidines	95-107	insulin	Homo sapiens	55-62
23417104-5	2013	RESULTS AND CONCLUSIONS: Thiazolidine ring-based compounds act as PPAR-gamma agonists, and herein, we have successfully developed nine derivatives of thiazolidine ring-based compounds that are found to be biologically potent using two-dimensional quantitative structure-activity relationship model.	Thiazolidines	25-37	peroxisome proliferator activated receptor gamma	Homo sapiens	66-76
23417104-5	2013	RESULTS AND CONCLUSIONS: Thiazolidine ring-based compounds act as PPAR-gamma agonists, and herein, we have successfully developed nine derivatives of thiazolidine ring-based compounds that are found to be biologically potent using two-dimensional quantitative structure-activity relationship model.	Thiazolidines	150-162	peroxisome proliferator activated receptor gamma	Homo sapiens	66-76
22867707-0	2012	A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells.	Thiazolidines	8-20	caspase 9	Homo sapiens	38-47
17381724-0	2007	Conformational stability of Abeta-(25-35) in the presence of thiazolidine derivatives.	Thiazolidines	61-73	amyloid beta precursor protein	Homo sapiens	28-33
21093259-1	2011	A new series of thiazolidine derivatives with an adamantyl group was synthesized and evaluated for their ability to inhibit 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1).	Thiazolidines	16-28	RNA, U1 small nuclear 1	Homo sapiens	124-174
20540935-1	2010	Peroxisome proliferator-activated receptor (PPAR)-gamma agonists such as troglitazone, pioglitazone and thiazolidine have been shown to induce apoptosis in human colon cancer cells.	Thiazolidines	104-116	peroxisome proliferator activated receptor gamma	Homo sapiens	0-55
21306895-0	2011	Discovery of beta-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors.	Thiazolidines	39-51	dipeptidylpeptidase 4	Rattus norvegicus	88-111
21306895-1	2011	A series of beta-aminoacyl containing thiazolidine derivatives was synthesized and evaluated for their ability to inhibit DPP-IV.	Thiazolidines	38-50	dipeptidylpeptidase 4	Rattus norvegicus	122-128
21306895-2	2011	Several thiazolidine derivatives with an acid moiety were found to be potent DPP-IV inhibitors.	Thiazolidines	8-20	dipeptidylpeptidase 4	Rattus norvegicus	77-83
19027993-4	2009	Important SAR information was also gathered, such as the contribution of thiocarbonyl attached at 4-position on the thiazolidine heterocyclic for antimicrobial properties.	Thiazolidines	116-128	sarcosine dehydrogenase	Homo sapiens	10-13
18480556-2	2008	Thiazolidine derivatives increase circulating adiponectin, particularly the high molecular weight isoform, which has been shown to well correlate with amelioration of insulin resistance by thiazolidines in diabetic patients.	Thiazolidines	0-12	adiponectin, C1Q and collagen domain containing	Homo sapiens	46-57
18480556-2	2008	Thiazolidine derivatives increase circulating adiponectin, particularly the high molecular weight isoform, which has been shown to well correlate with amelioration of insulin resistance by thiazolidines in diabetic patients.	Thiazolidines	0-12	insulin	Homo sapiens	167-174
18480556-2	2008	Thiazolidine derivatives increase circulating adiponectin, particularly the high molecular weight isoform, which has been shown to well correlate with amelioration of insulin resistance by thiazolidines in diabetic patients.	Thiazolidines	189-202	adiponectin, C1Q and collagen domain containing	Homo sapiens	46-57
18480556-2	2008	Thiazolidine derivatives increase circulating adiponectin, particularly the high molecular weight isoform, which has been shown to well correlate with amelioration of insulin resistance by thiazolidines in diabetic patients.	Thiazolidines	189-202	insulin	Homo sapiens	167-174
17095219-0	2007	Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias.	Thiazolidines	13-25	potassium voltage-gated channel subfamily A member 5	Homo sapiens	50-55
17095219-2	2007	The development and biological evaluation of a series of thiazolidine-based blockers of Kv1.5 is described.	Thiazolidines	57-69	potassium voltage-gated channel subfamily A member 5	Homo sapiens	88-93
16126938-8	2005	The NR ligands, vitamin D(3), trans/cis RA, glucocorticoids, and thiazolidines, induce dramatic changes in the physiology of cells harboring high Wnt/beta-catenin/Tcf activity.	Thiazolidines	65-78	catenin beta 1	Homo sapiens	150-162
16126938-8	2005	The NR ligands, vitamin D(3), trans/cis RA, glucocorticoids, and thiazolidines, induce dramatic changes in the physiology of cells harboring high Wnt/beta-catenin/Tcf activity.	Thiazolidines	65-78	hepatocyte nuclear factor 4 alpha	Homo sapiens	163-166