PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16707790-3	2006	Necdin binds to its homologous MAGE protein MAGE-D1 (also known as NRAGE or Dlxin-1), which interacts with Msx (msh homeobox) and Dlx (distal-less homeobox) family homeodomain transcription factors.	msx	107-110	necdin, MAGE family member	Mus musculus	0-6
19154605-5	2009	We demonstrate physical linkage between Msx and other MetaHox genes (Hmx, NK1, Emx) in a cnidarian.	msx	40-43	tachykinin receptor 1	Homo sapiens	74-77
17551260-9	2007	MSX, which had a prevalence of 31%, was significantly associated with elevated CRP levels.	msx	0-3	C-reactive protein	Homo sapiens	79-82
17551260-10	2007	Among MSX components, the strongest positive association with the highest quartile of CRP was with waist circumference in males as well as in females (age-adjusted odds ratio OR 3.06 and 95% confidence interval CI 1.82-5.14; OR 7.04 and 95% CI 4.79-10.34, respectively).	msx	6-9	C-reactive protein	Homo sapiens	86-89
17551260-16	2007	CONCLUSIONS: Abdominal adiposity adds to the variance in plasma CRP levels in elderly patients with MSX.	msx	100-103	C-reactive protein	Homo sapiens	64-67
18344319-4	2008	To identify genome-wide responses to such organic N signals, Arabidopsis seedlings were transiently treated with ammonium nitrate in the presence or absence of MSX, an inhibitor of glutamine synthetase, resulting in a block of Glu/Gln synthesis.	msx	160-163	hypothetical protein	Arabidopsis thaliana	181-201
16631154-9	2006	At the same time, Msx-depletion restores normal preplacodal gene expression to dlx3b-dlx4b mutants.	msx	18-21	distal-less homeobox 3b	Danio rerio	79-84
16631154-9	2006	At the same time, Msx-depletion restores normal preplacodal gene expression to dlx3b-dlx4b mutants.	msx	18-21	distal-less homeobox 4b	Danio rerio	85-90
16707790-3	2006	Necdin binds to its homologous MAGE protein MAGE-D1 (also known as NRAGE or Dlxin-1), which interacts with Msx (msh homeobox) and Dlx (distal-less homeobox) family homeodomain transcription factors.	msx	107-110	melanoma antigen	Mus musculus	31-35
16707790-3	2006	Necdin binds to its homologous MAGE protein MAGE-D1 (also known as NRAGE or Dlxin-1), which interacts with Msx (msh homeobox) and Dlx (distal-less homeobox) family homeodomain transcription factors.	msx	107-110	MAGE family member D1	Mus musculus	44-51
16707790-3	2006	Necdin binds to its homologous MAGE protein MAGE-D1 (also known as NRAGE or Dlxin-1), which interacts with Msx (msh homeobox) and Dlx (distal-less homeobox) family homeodomain transcription factors.	msx	107-110	MAGE family member D1	Mus musculus	67-72
16707790-3	2006	Necdin binds to its homologous MAGE protein MAGE-D1 (also known as NRAGE or Dlxin-1), which interacts with Msx (msh homeobox) and Dlx (distal-less homeobox) family homeodomain transcription factors.	msx	107-110	MAGE family member D1	Mus musculus	76-83
16707790-3	2006	Necdin binds to its homologous MAGE protein MAGE-D1 (also known as NRAGE or Dlxin-1), which interacts with Msx (msh homeobox) and Dlx (distal-less homeobox) family homeodomain transcription factors.	msx	107-110	distal-less homeobox 1	Mus musculus	76-79
15743757-8	2005	These findings strongly support a role for MSX and DLX in contributing to spatiotemporal regulation of GnRH transcription during development.	msx	43-46	gonadotropin releasing hormone 1	Homo sapiens	103-107
16487345-2	2006	Intracellular Gln3 localization and Gln3-dependent transcription respond in parallel to the nutritional environment and inhibitors of Tor1/2 (rapamycin) and glutamine synthetase (L-methionine sulfoximine, MSX).	msx	205-208	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	14-18
16487345-2	2006	Intracellular Gln3 localization and Gln3-dependent transcription respond in parallel to the nutritional environment and inhibitors of Tor1/2 (rapamycin) and glutamine synthetase (L-methionine sulfoximine, MSX).	msx	205-208	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	36-40
16487345-7	2006	In contrast, three characteristics of Gat1 and Gln3 differ significantly: (i) the kinetics of their localization in response to nutritional transitions and rapamycin-treatment; (ii) their opposite responses to MSX-treatment, i.e. that cytoplasmic Gln3 becomes nuclear following MSX addition, whereas nuclear Gat1 becomes cytoplasmic; and (iii) their phosphorylation levels in the above situations.	msx	210-213	Gat1p	Saccharomyces cerevisiae S288C	38-42
16487345-7	2006	In contrast, three characteristics of Gat1 and Gln3 differ significantly: (i) the kinetics of their localization in response to nutritional transitions and rapamycin-treatment; (ii) their opposite responses to MSX-treatment, i.e. that cytoplasmic Gln3 becomes nuclear following MSX addition, whereas nuclear Gat1 becomes cytoplasmic; and (iii) their phosphorylation levels in the above situations.	msx	210-213	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	47-51
16487345-7	2006	In contrast, three characteristics of Gat1 and Gln3 differ significantly: (i) the kinetics of their localization in response to nutritional transitions and rapamycin-treatment; (ii) their opposite responses to MSX-treatment, i.e. that cytoplasmic Gln3 becomes nuclear following MSX addition, whereas nuclear Gat1 becomes cytoplasmic; and (iii) their phosphorylation levels in the above situations.	msx	278-281	Gat1p	Saccharomyces cerevisiae S288C	38-42
16487345-7	2006	In contrast, three characteristics of Gat1 and Gln3 differ significantly: (i) the kinetics of their localization in response to nutritional transitions and rapamycin-treatment; (ii) their opposite responses to MSX-treatment, i.e. that cytoplasmic Gln3 becomes nuclear following MSX addition, whereas nuclear Gat1 becomes cytoplasmic; and (iii) their phosphorylation levels in the above situations.	msx	278-281	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	47-51
12909711-7	2003	Preceding Msx activation, there is a marked increase in the expression of notch1b and deltaC, which we show are also up-regulated during fin regeneration.	msx	10-13	notch receptor 1b	Danio rerio	74-81
12111224-9	2002	The inhibition of LEAMT1;2 expression by glutamine and the glutamine synthetase blocker L-methionine sulfoximine (MSX) provided evidence for the control of LEAMT1;2 expression by cytoplasmic NH(+)(4) concentration or the plant N status.	msx	114-117	ammonium transporter 1 member 2	Solanum lycopersicum	18-26
12111224-9	2002	The inhibition of LEAMT1;2 expression by glutamine and the glutamine synthetase blocker L-methionine sulfoximine (MSX) provided evidence for the control of LEAMT1;2 expression by cytoplasmic NH(+)(4) concentration or the plant N status.	msx	114-117	ammonium transporter 1 member 2	Solanum lycopersicum	156-164
10551692-9	1999	Glucose infusion rate was significantly lower in CSX and MSx groups than in normal controls (p < 0.01), suggesting that in both CSX and MSX groups insulin resistance is present.	msx	57-60	NK2 homeobox 5	Homo sapiens	131-134
12489206-7	2002	Finally, in the same cells, such combinations appeared to modulate VDR expression outlining the existence of complex cross-regulations between vitamin D and Msx/Dix pathways.	msx	157-160	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	67-70
11997479-6	2002	MSX-induced glutamine starvation caused nuclear localization and activation of the TOR-inhibited transcription factors GLN3, RTG1, and RTG3, all of which mediate glutamine synthesis.	msx	0-3	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	119-123
11997479-6	2002	MSX-induced glutamine starvation caused nuclear localization and activation of the TOR-inhibited transcription factors GLN3, RTG1, and RTG3, all of which mediate glutamine synthesis.	msx	0-3	Rtg1p	Saccharomyces cerevisiae S288C	125-129
11997479-6	2002	MSX-induced glutamine starvation caused nuclear localization and activation of the TOR-inhibited transcription factors GLN3, RTG1, and RTG3, all of which mediate glutamine synthesis.	msx	0-3	Rtg3p	Saccharomyces cerevisiae S288C	135-139
11997479-7	2002	The MSX-induced nuclear localization of GLN3 required the TOR-controlled, type 2A-related phosphatase SIT4.	msx	4-7	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	40-44
11997479-7	2002	The MSX-induced nuclear localization of GLN3 required the TOR-controlled, type 2A-related phosphatase SIT4.	msx	4-7	type 2A-related serine/threonine-protein phosphatase SIT4	Saccharomyces cerevisiae S288C	102-106
10551692-9	1999	Glucose infusion rate was significantly lower in CSX and MSx groups than in normal controls (p < 0.01), suggesting that in both CSX and MSX groups insulin resistance is present.	msx	57-60	insulin	Homo sapiens	150-157
28112327-5	2017	MSX (500 mug mL-1) reduced the formation of AGEs by 40% in the bovine serum albumin (BSA)-fructose assay and by 30% in the BSA-methylglyoxal (MGO) assay.	msx	0-3	L1 cell adhesion molecule	Mus musculus	13-17
12226254-1	1996	A strain of Chlamydomonas reinhardtii, named ARF-1, which grows with the glutamine synthetase (GS) inhibitor L-methionine-S-sulfoximine (MSX), has been isolated and characterized.	msx	137-140	uncharacterized protein	Chlamydomonas reinhardtii	73-93
8292072-4	1993	Alternatively the glutamine synthetase amplification system seems to be one of the most efficient expression systems using methionine sulphoximine (MSX) as selection pressure.	msx	148-151	glutamate-ammonia ligase	Homo sapiens	18-38
30841419-7	2019	MSX significantly inhibits mitochondrial outer membrane permeabilization (MOMP) reduces the release of cytochrome C and the shift of apoptosis inducing factor (AIF) from mitochondria to nucleus.	msx	0-3	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	133-158
30841419-7	2019	MSX significantly inhibits mitochondrial outer membrane permeabilization (MOMP) reduces the release of cytochrome C and the shift of apoptosis inducing factor (AIF) from mitochondria to nucleus.	msx	0-3	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	160-163
9205134-6	1997	It has been demonstrated that BMP4 can regulate cell death at these same sites as well as induce Msx expression.	msx	97-100	bone morphogenetic protein 4	Homo sapiens	30-34
11607250-4	1992	We also found that MSX induced dissimilatory reduction of NO3- to NH4+ in soil and that the NH4+ thus formed had no effect on the rate of NO-3 reduction.	msx	19-22	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
28112327-5	2017	MSX (500 mug mL-1) reduced the formation of AGEs by 40% in the bovine serum albumin (BSA)-fructose assay and by 30% in the BSA-methylglyoxal (MGO) assay.	msx	0-3	albumin	Homo sapiens	70-83
28112327-8	2017	In the anti-oxidant assays, MSX (61.7 mug mL-1) scavenged 50% of free radicals (DPPH assay) and reduced free radical generation by 20% during the glycation process (electron paramagnetic resonance time scan).	msx	28-31	L1 cell adhesion molecule	Mus musculus	42-46
28112327-9	2017	In addition, the intracellular levels of hydrogen peroxide induced reactive oxygen species were reduced by 27-58% with MSX (50-200 mug mL-1) in normal/non-tumorigenic human colon CCD-18Co cells.	msx	119-122	L1 cell adhesion molecule	Mus musculus	135-139
28112327-10	2017	Moreover, in AGEs and MGO challenged CCD-18Co cells, higher cellular viabilities and rapid extracellular signal-regulated kinase (ERK) phosphorylation were observed in MSX treated cells, indicating its protective effects against AGEs-induced cytotoxicity.	msx	168-171	mitogen-activated protein kinase 1	Homo sapiens	91-128
28112327-10	2017	Moreover, in AGEs and MGO challenged CCD-18Co cells, higher cellular viabilities and rapid extracellular signal-regulated kinase (ERK) phosphorylation were observed in MSX treated cells, indicating its protective effects against AGEs-induced cytotoxicity.	msx	168-171	mitogen-activated protein kinase 1	Homo sapiens	130-133
27689785-5	2017	In this study we have begun to address the relationship between MSX supplementation, the amount of intracellular GCL subunit and mAb production from a panel of GS-CHOK1SV cell lines.	msx	64-67	germ cell-less 2, spermatogenesis associated	Homo sapiens	113-116
27689785-7	2017	To the best of our knowledge, this paper describes for the first time the change in expression of GCL subunits and recombinant mAb production in these cell lines with the degree of MSX supplementation in routine subculture.	msx	181-184	germ cell-less 2, spermatogenesis associated	Homo sapiens	98-101
27689785-8	2017	Our data also shows that partial inhibition of GCL activity in medium containing 75 microM MSX increases mAb productivity, and its more specific inhibitor BSO used at a concentration of 80 microM in medium increases the specific rate of mAb production eight-fold and the concentration in harvest medium by two-fold.	msx	91-94	germ cell-less 2, spermatogenesis associated	Homo sapiens	47-50
26061551-5	2015	RESULTS: We found that retroviral-mediated in vivo overexpression of YPEL1 causes abnormal mandibular morphogenesis associated with increased apoptosis and involvement of the BMP/MSX pathway.	msx	179-182	yippee like 1	Homo sapiens	69-74
27689785-3	2017	However, MSX is not a specific inhibitor of GS as it also inhibits the activity of GCL (a key enzyme in the glutathione biosynthesis pathway) to a similar extent.	msx	9-12	germ cell-less 2, spermatogenesis associated	Homo sapiens	83-86
27418278-5	2016	MSX (100 mug/mL) decreased H2O2-induced oxidative stress (16.1 % decrease in ROS levels compared to control), and down-regulated the production of lipopolysaccharide (LPS)-stimulated inflammatory markers (22.1, 19.9, 74.8, and 87.6 % decrease in NOS, IL-6, PGE2, and TNFalpha levels, respectively, compared to control) in murine BV-2 microglial cells.	msx	0-3	interleukin 6	Mus musculus	251-255
27418278-5	2016	MSX (100 mug/mL) decreased H2O2-induced oxidative stress (16.1 % decrease in ROS levels compared to control), and down-regulated the production of lipopolysaccharide (LPS)-stimulated inflammatory markers (22.1, 19.9, 74.8, and 87.6 % decrease in NOS, IL-6, PGE2, and TNFalpha levels, respectively, compared to control) in murine BV-2 microglial cells.	msx	0-3	tumor necrosis factor	Mus musculus	267-275
23994266-3	2013	In the glutamine synthetase (GS)-CHO expression system, selection of top-producing cell lines is based on controlling the balance between the expression level of GS and the concentration of its specific inhibitor, l-methionine sulfoximine (MSX).	msx	240-243	glutamine synthetase	Cricetulus griseus	7-27