PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23892563-10	2013	This study proposes complementary mechanism where inhibition of proteasome activator protein (PA200) is responsible for accumulation of ubiquitinated-calcyclin, regulates deltamethrin-induced neoplastic changes in mouse skin and HaCaT cells.	decamethrin	171-183	S100 calcium binding protein A6 (calcyclin)	Mus musculus	150-159
23431972-1	2013	A deltamethrin-imprinted polymer (MIP(1)) was prepared using bis(-6-O-butanediacid monoester)-beta-cyclodextrin (BBA-beta-CD) as the functional monomer and toluene 2,4-diisocyanate (TDI) as the cross-linker.	decamethrin	2-14	transportin 1	Homo sapiens	34-40
23431972-2	2013	In comparison to the molecularly imprinted polymer where beta-CD was applied as the functional monomer (MIP(2)), MIP(1) showed a higher specific binding capacity (DeltaC(P)) and an improved imprinting factor (IF) for deltamethrin.	decamethrin	217-229	transportin 1	Homo sapiens	113-119
23431972-4	2013	The solid phase extraction (SPE) of deltamethrin using MIP(1) as the adsorbent was further investigated.	decamethrin	36-48	transportin 1	Homo sapiens	55-61
23282171-3	2012	Deltamethrin at concentrations of 5-60 muM increased [Ca2+]i in a concentration-dependent fashion.	decamethrin	0-12	latexin	Homo sapiens	39-42
22634057-4	2012	The aims of this study are to examine in vitro neurotoxicity of deltamethrin and its metabolites 3-phenoxybenzoic acid (3-PBA), 2"-OH-deltamethrin, and 4"-OH-deltamethrin and to evaluate melatonin (0.1, 1muM), trolox (0.3, 1muM) and N-acetylcysteine (500, 1000muM) protective role in SH-SY5Y cells.	decamethrin	64-76	latexin	Homo sapiens	204-207
22634059-0	2012	Deltamethrin inhibits osteoclast differentiation via regulation of heme oxygenase-1 and NFATc1.	decamethrin	0-12	heme oxygenase 1	Mus musculus	67-83
22634059-0	2012	Deltamethrin inhibits osteoclast differentiation via regulation of heme oxygenase-1 and NFATc1.	decamethrin	0-12	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	88-94
22634059-3	2012	In this study, we showed that deltamethrin inhibited OCL differentiation in vitro.	decamethrin	30-42	occludin	Mus musculus	53-56
22634059-4	2012	The effects of deltamethrin on OCL differentiation by receptor activator of nuclear factor kappa-B ligand (RANKL) were investigated in bone marrow-derived macrophages (BMMs) or the murine monocytic cell line RAW-D.	decamethrin	15-27	occludin	Mus musculus	31-34
22634059-5	2012	Treatment with deltamethrin inhibited OCL formation and bone resorption and up-regulated expression of heme oxygenase-1 (HO-1), an anti-oxidative stress enzyme.	decamethrin	15-27	occludin	Mus musculus	38-41
22634059-5	2012	Treatment with deltamethrin inhibited OCL formation and bone resorption and up-regulated expression of heme oxygenase-1 (HO-1), an anti-oxidative stress enzyme.	decamethrin	15-27	heme oxygenase 1	Mus musculus	103-119
22634059-6	2012	Deltamethrin also decreased the protein levels of nuclear factor of activated T cells cytoplasmic-1 (NFATc1), which is a master regulator for OCL differentiation, and concomitantly reduced the expression levels of Src and cathepsin K, which are transcriptionally regulated by NFATc1.	decamethrin	0-12	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	50-99
22634059-6	2012	Deltamethrin also decreased the protein levels of nuclear factor of activated T cells cytoplasmic-1 (NFATc1), which is a master regulator for OCL differentiation, and concomitantly reduced the expression levels of Src and cathepsin K, which are transcriptionally regulated by NFATc1.	decamethrin	0-12	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	101-107
22634059-6	2012	Deltamethrin also decreased the protein levels of nuclear factor of activated T cells cytoplasmic-1 (NFATc1), which is a master regulator for OCL differentiation, and concomitantly reduced the expression levels of Src and cathepsin K, which are transcriptionally regulated by NFATc1.	decamethrin	0-12	occludin	Mus musculus	142-145
22634059-6	2012	Deltamethrin also decreased the protein levels of nuclear factor of activated T cells cytoplasmic-1 (NFATc1), which is a master regulator for OCL differentiation, and concomitantly reduced the expression levels of Src and cathepsin K, which are transcriptionally regulated by NFATc1.	decamethrin	0-12	Rous sarcoma oncogene	Mus musculus	214-217
22634059-6	2012	Deltamethrin also decreased the protein levels of nuclear factor of activated T cells cytoplasmic-1 (NFATc1), which is a master regulator for OCL differentiation, and concomitantly reduced the expression levels of Src and cathepsin K, which are transcriptionally regulated by NFATc1.	decamethrin	0-12	cathepsin K	Mus musculus	222-233
22634059-6	2012	Deltamethrin also decreased the protein levels of nuclear factor of activated T cells cytoplasmic-1 (NFATc1), which is a master regulator for OCL differentiation, and concomitantly reduced the expression levels of Src and cathepsin K, which are transcriptionally regulated by NFATc1.	decamethrin	0-12	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	276-282
22634059-7	2012	The effects of deltamethrin on intracellular signaling during the OCL differentiation of BMMs indicated that deltamethrin-treated OCLs displayed impaired phosphorylation of extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, Jun N-terminal kinase, and Akt, and slightly delayed phosphorylation of inhibitor of nuclear factor kappa B alpha (IkappaBalpha) compared with untreated OCLs.	decamethrin	109-121	occludin	Mus musculus	66-69
22634059-7	2012	The effects of deltamethrin on intracellular signaling during the OCL differentiation of BMMs indicated that deltamethrin-treated OCLs displayed impaired phosphorylation of extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, Jun N-terminal kinase, and Akt, and slightly delayed phosphorylation of inhibitor of nuclear factor kappa B alpha (IkappaBalpha) compared with untreated OCLs.	decamethrin	109-121	mitogen-activated protein kinase 14	Mus musculus	212-215
22634059-7	2012	The effects of deltamethrin on intracellular signaling during the OCL differentiation of BMMs indicated that deltamethrin-treated OCLs displayed impaired phosphorylation of extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, Jun N-terminal kinase, and Akt, and slightly delayed phosphorylation of inhibitor of nuclear factor kappa B alpha (IkappaBalpha) compared with untreated OCLs.	decamethrin	109-121	thymoma viral proto-oncogene 1	Mus musculus	277-280
22634059-7	2012	The effects of deltamethrin on intracellular signaling during the OCL differentiation of BMMs indicated that deltamethrin-treated OCLs displayed impaired phosphorylation of extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, Jun N-terminal kinase, and Akt, and slightly delayed phosphorylation of inhibitor of nuclear factor kappa B alpha (IkappaBalpha) compared with untreated OCLs.	decamethrin	109-121	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	365-377
22634059-8	2012	Thus, deltamethrin possibly affects bone metabolism by inhibiting OCL differentiation.	decamethrin	6-18	occludin	Mus musculus	66-69
22939157-2	2012	The as-prepared MNPs/PSt were used as the adsorbent in magnetic solid phase extraction of five pyrethroids, including lambda-cyhalothrin, deltamethrin, esfenvalerate, permethrin, bifenthrin, in environmental water samples.	decamethrin	138-150	sulfotransferase family 1A member 1	Homo sapiens	21-24
23282171-7	2012	In Ca2+ -free medium, 50 muM deltamethrin pretreatment abolished the [Ca2+]i rise induced by the endoplasmic reticulum Ca2+ pump inhibitor thapsigargin (TG) or 2,5-di-tertbutylhydroquinone (BHQ).	decamethrin	29-41	latexin	Homo sapiens	25-28
23282171-10	2012	At concentrations between 10 and 80 muM deltamethrin killed cells in a concentration-dependent manner.	decamethrin	40-52	latexin	Homo sapiens	36-39
23282171-12	2012	Annexin V/ propidium iodide staining data suggest that deltamethrin (10-40 muM) induced apoptosis in a concentrationdependent manner.	decamethrin	55-67	annexin A5	Homo sapiens	0-9
23282171-12	2012	Annexin V/ propidium iodide staining data suggest that deltamethrin (10-40 muM) induced apoptosis in a concentrationdependent manner.	decamethrin	55-67	latexin	Homo sapiens	75-78
22768923-2	2012	Previous studies in our laboratory found that arrestin gene expression was higher in the deltamethrin-resistant (DR) strain than in the deltamethrin-susceptible (DS) strain of Cx.	decamethrin	89-101	Arrestin 1	Drosophila melanogaster	46-54
22768923-2	2012	Previous studies in our laboratory found that arrestin gene expression was higher in the deltamethrin-resistant (DR) strain than in the deltamethrin-susceptible (DS) strain of Cx.	decamethrin	136-148	Arrestin 1	Drosophila melanogaster	46-54
22768923-10	2012	In addition, the relationship between arrestin and deltamethrin (DM) resistance were identified using genetic overexpression strategies and arrestin RNAi in mosquito cells.	decamethrin	51-63	Arrestin 1	Drosophila melanogaster	38-46
22768923-16	2012	Arrestin overexpression comparably increased the mosquito cell viability, whereas arrestin knockdown by siRNA decreased mosquito cell viability with deltamethrin (DM) treatment.	decamethrin	149-161	Arrestin 1	Drosophila melanogaster	82-90
23569971-9	2012	While, no and slight inhibition was observed after the 2 weeks of treatment period with deltamethrin and fenitrothion reached to about 24% in plasma cholinesterase enzyme activity.	decamethrin	88-100	butyrylcholinesterase	Mus musculus	149-163
22347424-4	2012	METHODOLOGY/PRINCIPAL FINDINGS: The full length Cimex lectularius CPR (ClCPR) cDNA was isolated from a deltamethrin resistant bed bug population (CIN-1) using a combined PCR strategy.	decamethrin	103-115	NADPH--cytochrome P450 reductase	Cimex lectularius	66-69
22465659-0	2012	Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin.	decamethrin	153-165	neuron navigator 1	Rattus norvegicus	68-72
22465659-10	2012	These studies provide direct evidence for the preferential binding of deltamethrin and tefluthrin (but not S-bioallethrin) to Na(v)1.6Q3 channels in the open state and imply that the pyrethroid receptor of resting and open channels occupies different conformations that exhibit distinct structure-activity relationships.	decamethrin	70-82	neuron navigator 1	Rattus norvegicus	126-132
22429507-4	2012	We previously found that deltamethrin (DM), a type II pyrethroid, increased Bdnf mRNA expression in cultured rat cortical neurons.	decamethrin	25-37	brain-derived neurotrophic factor	Rattus norvegicus	76-80
22079160-0	2012	Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter.	decamethrin	0-12	brain-derived neurotrophic factor	Rattus norvegicus	118-122
22079160-2	2012	In a primary culture of rat cortical neurons, deltamethrin (DM), a type II pyrethroid, markedly enhanced the expression of brain-derived neurotrophic factor (BDNF) exon IV-IX (Bdnf eIV-IX) mRNA.	decamethrin	46-58	brain-derived neurotrophic factor	Rattus norvegicus	123-156
22079160-2	2012	In a primary culture of rat cortical neurons, deltamethrin (DM), a type II pyrethroid, markedly enhanced the expression of brain-derived neurotrophic factor (BDNF) exon IV-IX (Bdnf eIV-IX) mRNA.	decamethrin	46-58	brain-derived neurotrophic factor	Rattus norvegicus	158-162
22079160-2	2012	In a primary culture of rat cortical neurons, deltamethrin (DM), a type II pyrethroid, markedly enhanced the expression of brain-derived neurotrophic factor (BDNF) exon IV-IX (Bdnf eIV-IX) mRNA.	decamethrin	46-58	brain-derived neurotrophic factor	Rattus norvegicus	176-180
22479665-6	2012	METHODOLOGY/PRINCIPAL FINDINGS: We have expressed CYP9J32 in Escherichia coli and show that the enzyme can metabolize the pyrethroids permethrin and deltamethrin.	decamethrin	149-161	probable cytochrome P450 9f2	Aedes aegypti	50-57
21658436-0	2011	Impact of deltamethrin exposure on mRNA expression levels of metallothionein A, B and cytochrome P450 1A in rainbow trout muscles.	decamethrin	10-22	metallothionein A	Oncorhynchus mykiss	61-78
21983428-0	2011	Differential state-dependent modification of rat Na(v)1.6 sodium channels expressed in human embryonic kidney (HEK293) cells by the pyrethroid insecticides tefluthrin and deltamethrin.	decamethrin	171-183	sodium voltage-gated channel alpha subunit 8	Homo sapiens	49-57
21983428-7	2011	We assessed the use-dependent effects of tefluthrin and deltamethrin on Na(v)1.6 channels by determining the effect of trains of 1 to 100 5-ms depolarizing prepulses at frequencies of 20 or 66.7Hz on the extent of channel modification.	decamethrin	56-68	sodium voltage-gated channel alpha subunit 8	Homo sapiens	72-80
21983428-10	2011	These findings show that the actions of tefluthrin and deltamethrin of Na(v)1.6 channels in HEK293 cells differ from the effects of these compounds on Na(v)1.6 channels in Xenopus oocytes and more closely reflect the actions of pyrethroids on channels in their native neuronal environment.	decamethrin	55-67	sodium voltage-gated channel alpha subunit 8	Homo sapiens	71-79
21658436-7	2011	We observed that deltamethrin exposure significantly (p<0.05) increased the expression levels of Cyp1A, MT-A and MT-B in a time dependent manner.	decamethrin	17-29	metallothionein A	Oncorhynchus mykiss	107-111
21658436-7	2011	We observed that deltamethrin exposure significantly (p<0.05) increased the expression levels of Cyp1A, MT-A and MT-B in a time dependent manner.	decamethrin	17-29	mtb	Oncorhynchus mykiss	116-120
21640822-6	2011	Treatment of the wild-type channel with deltamethrin (>= 1 nM), permethrin (>= 30 nM) or DDT (>= 1 muM) resulted in hyperpolarizing shifts in V(50,act).	decamethrin	40-52	bicoid	Drosophila melanogaster	108-111
21640822-7	2011	Deltamethrin, permethrin and DDT also produced "tail currents" with EC50s of 0.043, 0.40 and 65 muM and maximum modifications of 837, 325 and 7% respectively.	decamethrin	0-12	bicoid	Drosophila melanogaster	96-99
21398409-0	2011	The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain.	decamethrin	14-26	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144
21398409-2	2011	We reported that Nrf2 expression was activated by deltamethrin (DM), a prototype of the widely used Parathyroid pesticides, in PC12 cells.	decamethrin	50-62	NFE2 like bZIP transcription factor 2	Rattus norvegicus	17-21
20869441-7	2011	Interestingly, the F to C mutation drastically reduced channel sensitivity to three type I pyrethroids, permethrin, NRDC 157 (a deltamethrin analogue lacking the alpha-cyano group) and bioresemthrin, but not to three type II pyrethroids, cypermethrin, deltamethrin and cyhalothrin.	decamethrin	128-140	nardilysin convertase L homeolog	Xenopus laevis	116-120
21555338-3	2011	To identify these pathways, SK-N-AS neuroblastoma cells were exposed to deltamethrin (100 nM-5 muM) for 24-48 h. Deltamethrin produced a time- and dose-dependent increase (21-300%) in DNA fragmentation, an indicator of apoptosis.	decamethrin	72-84	latexin	Homo sapiens	95-98
21555338-3	2011	To identify these pathways, SK-N-AS neuroblastoma cells were exposed to deltamethrin (100 nM-5 muM) for 24-48 h. Deltamethrin produced a time- and dose-dependent increase (21-300%) in DNA fragmentation, an indicator of apoptosis.	decamethrin	113-125	latexin	Homo sapiens	95-98
21555338-8	2011	This was confirmed by the observation that inhibition of eIF2alpha abolished deltamethrin-induced DNA fragmentation.	decamethrin	77-89	eukaryotic translation initiation factor 2A	Homo sapiens	57-66
21324359-6	2011	Rates were enhanced by A. gambiae cytochrome b(5) with kinetic parameters of K(M)=11+-1muM and k(cat)=6.1+-0.4 per min for permethrin (1:1 cis-trans) and K(M)=2.0+-0.3muM and k(cat)=1.2+-0.1 per min for deltamethrin.	decamethrin	203-215	cytochrome b	Anopheles gambiae	34-46
21195177-6	2011	Partial silencing of either GSTe7 or GSTe2 by RNA interference resulted in an increased susceptibility to the pyrethroid, deltamethrin suggesting that these GST enzymes may also play a role in resistance to pyrethroid insecticides.	decamethrin	122-134	glutathione S-transferase 1	Aedes aegypti	28-33
21195177-6	2011	Partial silencing of either GSTe7 or GSTe2 by RNA interference resulted in an increased susceptibility to the pyrethroid, deltamethrin suggesting that these GST enzymes may also play a role in resistance to pyrethroid insecticides.	decamethrin	122-134	glutathione S-transferase 1	Aedes aegypti	37-42
20647053-1	2010	We report here the acute and long-term influences of deltamethrin on the expression of IGF-I, IGF-II and GH-I in rainbow trout muscles.	decamethrin	53-65	insulin-like growth factor I	Oncorhynchus mykiss	87-92
20647053-1	2010	We report here the acute and long-term influences of deltamethrin on the expression of IGF-I, IGF-II and GH-I in rainbow trout muscles.	decamethrin	53-65	insulin-like growth factor II	Oncorhynchus mykiss	94-100
20410462-4	2010	We used recently completed whole-genome sequence of T. castaneum to prepare custom microarrays and identified a P450 gene, CYP6BQ9, which showed more than a 200-fold higher expression in the deltamethrin-resistant QTC279 strain when compared with its expression in the deltamethrin-susceptible Lab-S strain.	decamethrin	191-203	cytochrome P450 CYP6BQ9	Tribolium castaneum	123-130
20647053-2	2010	We treated rainbow trouts with different concentrations of deltamethrin (0.25 microg/L, 1 microg/L and 2.5 microg/L) and observed the alterations in mRNA expression levels of IGF-I, IGF-II and GH-I at different time intervals (at 6th, 12th, 24th, 48th, 72nd hours and 30th day).	decamethrin	59-71	insulin-like growth factor I	Oncorhynchus mykiss	175-180
20647053-5	2010	Here we demonstrate that deltamethrin exposure decreases the expression of IGF-I, IGF-II and GH-I in rainbow trout which might cause undesirable outcomes not only in growth, but also in development and reproduction.	decamethrin	25-37	insulin-like growth factor I	Oncorhynchus mykiss	75-80
20647053-5	2010	Here we demonstrate that deltamethrin exposure decreases the expression of IGF-I, IGF-II and GH-I in rainbow trout which might cause undesirable outcomes not only in growth, but also in development and reproduction.	decamethrin	25-37	insulin-like growth factor II	Oncorhynchus mykiss	82-88
20547410-1	2010	An evaluation of the Potential Dermal Exposure for the mix/load, application and re-entry stages, associated with procymidone and deltamethrin usage, was carried out for tomatoes grown in greenhouses of small production units in Argentina.	decamethrin	130-142	Mix paired-like homeobox	Homo sapiens	55-58
20417719-5	2010	In addition, we detected that deltamethrin increased the expression of the stress-related protein Hsp70 with significant fold-chance values.	decamethrin	30-42	heat shock protein family A (Hsp70) member 8b	Oncorhynchus mykiss	98-103
20410157-5	2010	Antagonistic effects to AR were found in 7 compounds, with cyfluthrin and deltamethrin exhibiting stronger AR antagonistic capacity.	decamethrin	74-86	androgen receptor	Homo sapiens	107-109
20410462-4	2010	We used recently completed whole-genome sequence of T. castaneum to prepare custom microarrays and identified a P450 gene, CYP6BQ9, which showed more than a 200-fold higher expression in the deltamethrin-resistant QTC279 strain when compared with its expression in the deltamethrin-susceptible Lab-S strain.	decamethrin	269-281	cytochrome P450 CYP6BQ9	Tribolium castaneum	123-130
20410462-5	2010	Functional studies using both double-strand RNA (dsRNA)-mediated knockdown in the expression of CYP6BQ9 and transgenic expression of CYP6BQ9 in Drosophila melanogaster showed that CYP6BQ9 confers deltamethrin resistance.	decamethrin	196-208	cytochrome P450 CYP6BQ9	Tribolium castaneum	133-140
20410462-5	2010	Functional studies using both double-strand RNA (dsRNA)-mediated knockdown in the expression of CYP6BQ9 and transgenic expression of CYP6BQ9 in Drosophila melanogaster showed that CYP6BQ9 confers deltamethrin resistance.	decamethrin	196-208	cytochrome P450 CYP6BQ9	Tribolium castaneum	133-140
20410462-6	2010	Furthermore, CYP6BQ9 enzyme expressed in baculovirus metabolizes deltamethrin to 4-hydroxy deltamethrin.	decamethrin	65-77	cytochrome P450 CYP6BQ9	Tribolium castaneum	13-20
20410462-7	2010	Strikingly, we also found that unlike many P450 genes involved in insecticide resistance that were reported previously, CYP6BQ9 is predominantly expressed in the brain, a part of the central nervous system (CNS) containing voltage-gated sodium channels targeted by deltamethrin.	decamethrin	265-277	cytochrome P450 CYP6BQ9	Tribolium castaneum	120-127
20143453-2	2010	Previous work demonstrated increases in the expression of Ca(2+)/calmodulin-dependent protein kinase 1-gamma (Camk1g) mRNA following acute deltamethrin and permethrin exposure.	decamethrin	139-151	calcium/calmodulin-dependent protein kinase IG	Rattus norvegicus	58-108
20143453-2	2010	Previous work demonstrated increases in the expression of Ca(2+)/calmodulin-dependent protein kinase 1-gamma (Camk1g) mRNA following acute deltamethrin and permethrin exposure.	decamethrin	139-151	calcium/calmodulin-dependent protein kinase IG	Rattus norvegicus	110-116
19748499-5	2009	Treatment with deltamethrin caused nerve cell loss and the appearance of signs of neuronal sufferance primarily in layer III of frontal cortex as well as in the dentate gyrus and to a lesser extent in the CA1 and CA3 subfields of hippocampus.	decamethrin	15-27	carbonic anhydrase 1	Rattus norvegicus	205-208
19748499-5	2009	Treatment with deltamethrin caused nerve cell loss and the appearance of signs of neuronal sufferance primarily in layer III of frontal cortex as well as in the dentate gyrus and to a lesser extent in the CA1 and CA3 subfields of hippocampus.	decamethrin	15-27	carbonic anhydrase 3	Rattus norvegicus	213-216
19442819-0	2009	Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes.	decamethrin	24-36	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	81-89
20137388-0	2009	[Effect of deltamethrin on production of free radical and transcription factor Nrf2 in rats" brain tissue].	decamethrin	11-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	79-83
20137388-1	2009	OBJECTIVE: To explore the effect of deltamethrin (DM) on production of free radical and transcription factor Nrf2 in rats" brain tissue.	decamethrin	36-48	NFE2 like bZIP transcription factor 2	Rattus norvegicus	109-113
20183062-5	2009	Deltamethrin and fenvalerate were potent inhibitors of CYP2D6 (IC(50) values of approximately 3 micro M) while lambda-cyhalothrin potently inhibited both CYP2D6 and CYP3A4-mediated activities (IC(50)"s about 3-4 micro M).	decamethrin	0-12	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	55-61
19118624-0	2009	S100beta upregulation: a possible mechanism of deltamethrin toxicity and motor coordination deficits.	decamethrin	47-59	S100 calcium binding protein B	Homo sapiens	0-8
19442819-1	2009	Single channel analysis was used to compare the electrophysiological properties of wild-type (WT) and I874M mutant (M874) rat Na(V)1.2 channels expressed in Xenopus oocytes and their modulation by the pyrethroid deltamethrin.	decamethrin	212-224	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	126-134
18538810-12	2008	These data demonstrate a greater sensitivity of Na(v)1.3 vs Na(v)1.2 channels to deltamethrin and other cyano-containing pyrethroids, particularly in the presence of a beta subunit.	decamethrin	81-93	sodium voltage-gated channel alpha subunit 3	Rattus norvegicus	48-56
18983829-0	2009	Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin.	decamethrin	143-155	carboxylesterase 1	Homo sapiens	24-28
18983829-0	2009	Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin.	decamethrin	143-155	carboxylesterase 2	Homo sapiens	33-37
18602378-3	2008	Joined actions of deltamethrin and pirimicarb (carbamate), alone or in association (dual treatment), were investigated on AChE activity in surviving and dead honeybees in order to test its reliability as biomarker.	decamethrin	18-30	acetylcholinesterase 2	Apis mellifera	122-126
18602378-5	2008	In surviving bees, deltamethrin treatment induced an important increase of AChE activity that is not abolished by pirimicarb treatment.	decamethrin	19-31	acetylcholinesterase 2	Apis mellifera	75-79
18602378-8	2008	The important increase in AChE activity in response to deltamethrin, not altered by pirimicarb treatment, suggests that AChE activity could represent a robust biomarker specific to deltamethrin exposure in living bees.	decamethrin	55-67	acetylcholinesterase 2	Apis mellifera	26-30
18602378-8	2008	The important increase in AChE activity in response to deltamethrin, not altered by pirimicarb treatment, suggests that AChE activity could represent a robust biomarker specific to deltamethrin exposure in living bees.	decamethrin	181-193	acetylcholinesterase 2	Apis mellifera	26-30
18602378-8	2008	The important increase in AChE activity in response to deltamethrin, not altered by pirimicarb treatment, suggests that AChE activity could represent a robust biomarker specific to deltamethrin exposure in living bees.	decamethrin	181-193	acetylcholinesterase 2	Apis mellifera	120-124
19493498-0	2009	[Role of interleukin-1 beta in deltamethrin neurotoxicity].	decamethrin	31-43	interleukin 1 beta	Homo sapiens	9-27
18538810-6	2008	Effects of deltamethrin were dependent on subunit combination; Na(v)1.3-containing channels were modified to a greater extent than were Na(v)1.2-containing channels.	decamethrin	11-23	sodium voltage-gated channel alpha subunit 3	Rattus norvegicus	63-71
18538810-6	2008	Effects of deltamethrin were dependent on subunit combination; Na(v)1.3-containing channels were modified to a greater extent than were Na(v)1.2-containing channels.	decamethrin	11-23	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	136-144
18538810-7	2008	In the presence of a beta subunit, deltamethrin effects were significantly greater, an effect most pronounced for Na(v)1.3 channels; Na(v)1.3/beta(3) channels were more sensitive to deltamethrin than Na(v)1.2/beta(1) channels.	decamethrin	35-47	sodium voltage-gated channel alpha subunit 3	Rattus norvegicus	114-122
18538810-7	2008	In the presence of a beta subunit, deltamethrin effects were significantly greater, an effect most pronounced for Na(v)1.3 channels; Na(v)1.3/beta(3) channels were more sensitive to deltamethrin than Na(v)1.2/beta(1) channels.	decamethrin	182-194	sodium voltage-gated channel alpha subunit 3	Rattus norvegicus	133-141
18538810-12	2008	These data demonstrate a greater sensitivity of Na(v)1.3 vs Na(v)1.2 channels to deltamethrin and other cyano-containing pyrethroids, particularly in the presence of a beta subunit.	decamethrin	81-93	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	60-68
18724894-0	2008	[Effects of melatonin on nerve cell apoptosis and expression of Bcl-2 & cytochrome C genes in rat cerebrum with deltamethrin induction].	decamethrin	116-128	BCL2, apoptosis regulator	Rattus norvegicus	64-69
18724894-1	2008	OBJECTIVE: To study the effects of melatonin (MT) on nerve cell apoptosis and the expression of bcl-2 and cytochrome C genes in rat cerebrum with deltamethrin induction.	decamethrin	146-158	BCL2, apoptosis regulator	Rattus norvegicus	96-101
17215041-0	2008	Honeybee Apis mellifera acetylcholinesterase--a biomarker to detect deltamethrin exposure.	decamethrin	68-80	acetylcholinesterase	Apis mellifera	24-44
17215041-1	2008	The purpose of this study is to investigate the possibility to use acetylcholinesterase (AChE) as a biomarker of exposure to deltamethrin insecticide in the honeybee, Apis mellifera and to test its reliability in the presence of other contaminants, as carbamate insecticide.	decamethrin	125-137	acetylcholinesterase	Apis mellifera	67-87
17215041-5	2008	The analysis of membrane and soluble AChE forms revealed an increase in the soluble form in dead bees after deltamethrin and dual treatment.	decamethrin	108-120	acetylcholinesterase	Apis mellifera	37-41
17215041-7	2008	The results suggest that the action of deltamethrin on AChE activity, in honeybee intact organisms, could be due to indirect mechanisms.	decamethrin	39-51	acetylcholinesterase	Apis mellifera	55-59
17215041-1	2008	The purpose of this study is to investigate the possibility to use acetylcholinesterase (AChE) as a biomarker of exposure to deltamethrin insecticide in the honeybee, Apis mellifera and to test its reliability in the presence of other contaminants, as carbamate insecticide.	decamethrin	125-137	acetylcholinesterase	Apis mellifera	89-93
17215041-8	2008	The duality of AChE response to deltamethrin exposure, exhibited by the possibility of increase (surviving bees) or decrease (dead bees) of its activity has been pointed out for the first time.	decamethrin	32-44	acetylcholinesterase	Apis mellifera	15-19
17215041-2	2008	Joined actions of deltamethrin (pyrethroid) and pirimicarb (carbamate), alone or in association, are investigated on AChE activity in surviving and dead honeybees, with a special focus on the relative proportions of its membrane and soluble forms.	decamethrin	18-30	acetylcholinesterase	Apis mellifera	117-121
17215041-3	2008	At the 0.5X dose (12.5 ng of deltamethrin and/or 2.5 microg of pirimicarb per bee), the residual tissue AChE activity in dead bees was 78% with deltamethrin, 43% with pirimicarb and 33% with dual treatment.	decamethrin	29-41	acetylcholinesterase	Apis mellifera	104-108
17215041-9	2008	The important increase in AChE activity in response to deltamethrin, not altered by pirimicarb treatment, suggests that AChE activity could represent a robust biomarker specific to deltamethrin exposure in living bees.	decamethrin	55-67	acetylcholinesterase	Apis mellifera	26-30
17215041-4	2008	In surviving bees, tissue AChE activity represented 250%, and 270% of control AChE activity with deltamethrin and dual treatment, respectively.	decamethrin	97-109	acetylcholinesterase	Apis mellifera	26-30
17215041-9	2008	The important increase in AChE activity in response to deltamethrin, not altered by pirimicarb treatment, suggests that AChE activity could represent a robust biomarker specific to deltamethrin exposure in living bees.	decamethrin	181-193	acetylcholinesterase	Apis mellifera	26-30
17507155-4	2007	Deltamethrin, an inhibitor of Ca(2+)-activated phosphatase, delayed Akt and Bad dephosphorylations, and then protected MIN6N8a cells from palmitate-induced apoptosis.	decamethrin	0-12	thymoma viral proto-oncogene 1	Mus musculus	68-71
17215041-9	2008	The important increase in AChE activity in response to deltamethrin, not altered by pirimicarb treatment, suggests that AChE activity could represent a robust biomarker specific to deltamethrin exposure in living bees.	decamethrin	181-193	acetylcholinesterase	Apis mellifera	120-124
19326768-3	2008	The objectives of this study were to evaluate the potential of deltamethrin and permethrin to cause cytotoxicity and to induce CYP isoforms in human hepatocytes.	decamethrin	63-75	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	127-130
19326768-7	2008	Dose-dependent induction of caspase-3/7 was initiated by 12.5 microM deltamethrin or by 3.125 microM permethrin.	decamethrin	69-81	caspase 3	Homo sapiens	28-37
19326768-9	2008	At 100 microM deltamethrin 2-3 fold induction of CYP1A1 and CYP2B6 mRNA was observed, while at the same time an approximately 25-fold induction of CYP3A4 was noted.	decamethrin	14-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-55
19326768-9	2008	At 100 microM deltamethrin 2-3 fold induction of CYP1A1 and CYP2B6 mRNA was observed, while at the same time an approximately 25-fold induction of CYP3A4 was noted.	decamethrin	14-26	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	60-66
19326768-9	2008	At 100 microM deltamethrin 2-3 fold induction of CYP1A1 and CYP2B6 mRNA was observed, while at the same time an approximately 25-fold induction of CYP3A4 was noted.	decamethrin	14-26	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	147-153
17676812-0	2007	NF-E2 related factor 2 activation and heme oxygenase-1 induction by tert-butylhydroquinone protect against deltamethrin-mediated oxidative stress in PC12 cells.	decamethrin	107-119	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-22
17676812-0	2007	NF-E2 related factor 2 activation and heme oxygenase-1 induction by tert-butylhydroquinone protect against deltamethrin-mediated oxidative stress in PC12 cells.	decamethrin	107-119	heme oxygenase 1	Rattus norvegicus	38-54
17917914-9	2007	The results indicated that of all the endpoints examined, among the rats exposed over a 2-day period to the imiprothrin- and deltamethrin-containing insecticide aerosol, the only significant change noted (relative to values from time-matched controls) was in the levels of splenic CD4+CD8- and CD4+ CD8+ cells.	decamethrin	125-137	Cd4 molecule	Rattus norvegicus	281-284
17917914-9	2007	The results indicated that of all the endpoints examined, among the rats exposed over a 2-day period to the imiprothrin- and deltamethrin-containing insecticide aerosol, the only significant change noted (relative to values from time-matched controls) was in the levels of splenic CD4+CD8- and CD4+ CD8+ cells.	decamethrin	125-137	Cd4 molecule	Rattus norvegicus	294-297
17576809-0	2007	Identification of rat and human cytochrome p450 isoforms and a rat serum esterase that metabolize the pyrethroid insecticides deltamethrin and esfenvalerate.	decamethrin	126-138	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	43-47
17576809-3	2007	Using a parent depletion approach, rat and human cytochromes P450 (P450s) were screened for their ability to eliminate deltamethrin or esfenvalerate during in vitro incubations.	decamethrin	119-131	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	61-65
17576809-3	2007	Using a parent depletion approach, rat and human cytochromes P450 (P450s) were screened for their ability to eliminate deltamethrin or esfenvalerate during in vitro incubations.	decamethrin	119-131	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	67-72
17576809-6	2007	Rat and human P450s that metabolize esfenvalerate and deltamethrin do so with similar kinetics.	decamethrin	54-66	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	14-19
20020880-0	2007	The evaluation of altered antioxidative defense mechanism and acetylcholinesterase activity in rat brain exposed to chlorpyrifos, deltamethrin, and their combination.	decamethrin	130-142	acetylcholinesterase	Rattus norvegicus	62-82
17540521-0	2007	Transcription factor Nrf2 activation by deltamethrin in PC12 cells: Involvement of ROS.	decamethrin	40-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	21-25
17540521-2	2007	To gain insights into dopaminergic cell responses to pesticides, the present study was conducted to examine the effects of deltamethrin (DM), a prototype of widely used pyrithroid pesticides, on the activation and expression of Nrf2 in PC12 rat adrenal pheochromocytoma cells as a dopaminergic cell model.	decamethrin	123-135	NFE2 like bZIP transcription factor 2	Rattus norvegicus	228-232
17055627-4	2007	Among the enzymatic antioxidants, activity of superoxide dismutase, ascorbate peroxidase and glutathione reductase increased significantly whereas that of catalase declined markedly in relation to increasing concentration of Deltamethrin applied.	decamethrin	225-237	peroxidase	Glycine max	78-88
17055627-4	2007	Among the enzymatic antioxidants, activity of superoxide dismutase, ascorbate peroxidase and glutathione reductase increased significantly whereas that of catalase declined markedly in relation to increasing concentration of Deltamethrin applied.	decamethrin	225-237	glutathione reductase, chloroplastic	Glycine max	93-114
17294162-4	2007	These findings delineate a separate action for deltamethrin and implicate N-type rat brain Ca(v)2.2 voltage-sensitive calcium channels (VSCC) as target sites that are consistent with the in vivo release of neurotransmitter caused by deltamethrin.	decamethrin	233-245	caveolin 2	Rattus norvegicus	91-97
17294162-10	2007	Collectively, these results substantiate that Ca(v)2.2 is directly modified by deltamethrin but the resulting perturbation is dependent upon the phosphorylation state of Ca(v)2.2.	decamethrin	79-91	caveolin 2	Rattus norvegicus	46-52
20020880-3	2007	Biochemical analysis showed that administration of chlorpyrifos and deltamethrin causes brain damage via production of MDA and inhibition of AChE.	decamethrin	68-80	acetylcholinesterase	Rattus norvegicus	141-145
20020880-7	2007	The effects of combination of DM and CP on LPO may be due to functional, dispositional, or chemical antagonism, while the effect of the combination on CAT activity may be synergistic.	decamethrin	30-32	lactoperoxidase	Rattus norvegicus	43-46
16952383-1	2006	Oral administration of deltamethrin (5 mg/kg x7 or 15 or 21 days) was found to produce a time-dependent increase in the mRNA expression of xenobiotic metabolizing cytochrome P450 1A1 (CYP1A1), 1A2 and CYP2B1, 2B2 isoenzymes in rat brain.	decamethrin	23-35	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	163-182
16952383-1	2006	Oral administration of deltamethrin (5 mg/kg x7 or 15 or 21 days) was found to produce a time-dependent increase in the mRNA expression of xenobiotic metabolizing cytochrome P450 1A1 (CYP1A1), 1A2 and CYP2B1, 2B2 isoenzymes in rat brain.	decamethrin	23-35	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	184-190
16952383-1	2006	Oral administration of deltamethrin (5 mg/kg x7 or 15 or 21 days) was found to produce a time-dependent increase in the mRNA expression of xenobiotic metabolizing cytochrome P450 1A1 (CYP1A1), 1A2 and CYP2B1, 2B2 isoenzymes in rat brain.	decamethrin	23-35	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	201-207
16952383-6	2006	Immunoblotting studies carried out with polyclonal antibody raised against rat liver CYP1A1/1A2 or CYP2B1/2B2 isoenzymes also showed increase in immunoreactivity comigrating with CYP1A1/1A2 or 2B1/2B2 in the microsomal fractions isolated from hippocampus, hypothalamus and cerebellum of rat treated with deltamethrin.	decamethrin	304-316	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	85-91
16952383-6	2006	Immunoblotting studies carried out with polyclonal antibody raised against rat liver CYP1A1/1A2 or CYP2B1/2B2 isoenzymes also showed increase in immunoreactivity comigrating with CYP1A1/1A2 or 2B1/2B2 in the microsomal fractions isolated from hippocampus, hypothalamus and cerebellum of rat treated with deltamethrin.	decamethrin	304-316	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	99-105
16952383-6	2006	Immunoblotting studies carried out with polyclonal antibody raised against rat liver CYP1A1/1A2 or CYP2B1/2B2 isoenzymes also showed increase in immunoreactivity comigrating with CYP1A1/1A2 or 2B1/2B2 in the microsomal fractions isolated from hippocampus, hypothalamus and cerebellum of rat treated with deltamethrin.	decamethrin	304-316	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	179-185
16790556-12	2006	Preincubation of CYP3A4 with chlorpyrifos, fonofos, deltamethrin, or permethrin resulted in 94, 87, 58, and 37% inhibition of E2 metabolism.	decamethrin	52-64	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	17-23
16978760-2	2006	The objective of this study was to investigate the propensity of deltamethrin to induce oxidative stress and changes in biochemical parameters and enzyme activities in male rats following a short-term (30 days) oral exposure and its possible attenuation by Vitamin E (Vit.	decamethrin	65-77	vitrin	Rattus norvegicus	257-260
16978760-9	2006	The activities of glutathione S-transferase (GST) and superoxide dismutase (SOD) were significantly decreased due to deltamethrin administration.	decamethrin	117-129	hematopoietic prostaglandin D synthase	Rattus norvegicus	18-43
16978760-9	2006	The activities of glutathione S-transferase (GST) and superoxide dismutase (SOD) were significantly decreased due to deltamethrin administration.	decamethrin	117-129	hematopoietic prostaglandin D synthase	Rattus norvegicus	45-48
16855054-9	2006	Results of CE metabolism revealed that human carboxylesterase 1 (hCE-1) was markedly more active toward deltamethrin than the class 1 rat CEs hydrolase A and B and the class 2 human CE (hCE-2); however, hydrolase A metabolized esfenvalerate 2-fold faster than hCE-1, whereas hydrolase B and hCE-1 hydrolyzed esfenvalerate at equal rates.	decamethrin	104-116	carboxylesterase 1	Homo sapiens	45-63
16855054-9	2006	Results of CE metabolism revealed that human carboxylesterase 1 (hCE-1) was markedly more active toward deltamethrin than the class 1 rat CEs hydrolase A and B and the class 2 human CE (hCE-2); however, hydrolase A metabolized esfenvalerate 2-fold faster than hCE-1, whereas hydrolase B and hCE-1 hydrolyzed esfenvalerate at equal rates.	decamethrin	104-116	carboxylesterase 1	Homo sapiens	65-70
16310970-5	2006	Recent studies in vivo and in vitro have shown that the inducible effect of deltamethrin on brain-derived neurotrophic factor (BDNF) gene expression is very potent and tends to be sustained.	decamethrin	76-88	brain derived neurotrophic factor	Homo sapiens	92-125
16494911-3	2006	RT-PCR analysis revealed dose-dependent increase in the mRNA expression of cerebral and hepatic CYP1A1, 1A2, 2B1, 2B2, and 2E1 isoenzymes in the offsprings exposed prenatally to deltamethrin.	decamethrin	178-190	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-102
16494911-7	2006	The present data indicating alterations in the expression of xenobiotic metabolizing CYPs during development following prenatal exposure to deltamethrin may be of significance as these CYP enzymes are not only involved in the neurobehavioral toxicity of deltamethrin but have a role in regulating the levels of ligands that modulate growth, differentiation, and neuroendocrine functions.	decamethrin	140-152	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	85-88
16494911-7	2006	The present data indicating alterations in the expression of xenobiotic metabolizing CYPs during development following prenatal exposure to deltamethrin may be of significance as these CYP enzymes are not only involved in the neurobehavioral toxicity of deltamethrin but have a role in regulating the levels of ligands that modulate growth, differentiation, and neuroendocrine functions.	decamethrin	254-266	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	85-88
16737586-0	2006	[Effects of deltamethrin on gene expression of some antioxidase, gamma glutamylcysteine synthetase and NFE2 related factor 2 (Nrf2) in brain tissue].	decamethrin	12-24	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	65-98
16737586-0	2006	[Effects of deltamethrin on gene expression of some antioxidase, gamma glutamylcysteine synthetase and NFE2 related factor 2 (Nrf2) in brain tissue].	decamethrin	12-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	103-124
16737586-0	2006	[Effects of deltamethrin on gene expression of some antioxidase, gamma glutamylcysteine synthetase and NFE2 related factor 2 (Nrf2) in brain tissue].	decamethrin	12-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	126-130
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	35-47	superoxide dismutase 1	Rattus norvegicus	106-114
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	35-47	glutathione-disulfide reductase	Rattus norvegicus	117-138
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	35-47	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	148-181
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	49-51	superoxide dismutase 1	Rattus norvegicus	106-114
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	49-51	glutathione-disulfide reductase	Rattus norvegicus	117-138
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	49-51	glutathione-disulfide reductase	Rattus norvegicus	140-142
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	49-51	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	148-181
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	49-51	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	183-192
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	49-51	glycine cleavage system protein H	Rattus norvegicus	269-292
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	49-51	glycine cleavage system protein H	Rattus norvegicus	294-298
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	49-51	NFE2 like bZIP transcription factor 2	Rattus norvegicus	304-325
16737586-1	2006	OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.	decamethrin	49-51	NFE2 like bZIP transcription factor 2	Rattus norvegicus	327-331
16169030-14	2006	CYP1A2, CYP1A1, and CYP2C11 in decreasing order of importance quantitatively, metabolized deltamethrin.	decamethrin	90-102	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	0-6
16169030-14	2006	CYP1A2, CYP1A1, and CYP2C11 in decreasing order of importance quantitatively, metabolized deltamethrin.	decamethrin	90-102	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	8-14
16169030-14	2006	CYP1A2, CYP1A1, and CYP2C11 in decreasing order of importance quantitatively, metabolized deltamethrin.	decamethrin	90-102	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	20-27
16005927-4	2006	Here, we report that repeated exposure (3 injections over 2 weeks) of mice to two commonly used pyrethroid pesticides, deltamethrin (3 mg/kg) and permethrin (0.8 mg/kg), increases DAT-mediated dopamine uptake by 31 and 28%, respectively.	decamethrin	119-131	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	180-183
16005927-9	2006	Since DAT can greatly affect the vulnerability of dopamine neurons to neurotoxicants, up-regulation of DAT by deltamethrin and permethrin may increase the susceptibility of dopamine neurons to toxic insult, which may provide insight into the association between pesticide exposure and PD.	decamethrin	110-122	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	103-106
16051293-10	2006	Modification of Na v 1.8 sodium channels by cyfluthrin, cyhalothrin, cypermethrin and deltamethrin was enhanced 2.3- to 3.4-fold by repetitive stimulation; this effect appeared to result from the accumulation of persistently open channels rather than preferential binding to open channel states.	decamethrin	86-98	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	16-24
16166269-0	2006	Deltamethrin, a pyrethroid insecticide, is a potent inducer for the activity-dependent gene expression of brain-derived neurotrophic factor in neurons.	decamethrin	0-12	brain-derived neurotrophic factor	Rattus norvegicus	106-139
16166269-3	2006	In this study, we found that deltamethrin, a type II pyrethroid insecticide, was highly effective in inducing BDNF expression in culture and in the rat brain.	decamethrin	29-41	brain-derived neurotrophic factor	Rattus norvegicus	110-114
16166269-4	2006	Addition of deltamethrin to rat cortical cells in culture markedly increased the expression of BDNF exon III-V mRNA and protein, dependent upon the neuronal activity accompanying the influx of Ca(2+) into neurons and the Ca(2+) influx-dependent phosphorylation of extracellular signal-regulated kinases 1/2.	decamethrin	12-24	brain-derived neurotrophic factor	Rattus norvegicus	95-99
16166269-4	2006	Addition of deltamethrin to rat cortical cells in culture markedly increased the expression of BDNF exon III-V mRNA and protein, dependent upon the neuronal activity accompanying the influx of Ca(2+) into neurons and the Ca(2+) influx-dependent phosphorylation of extracellular signal-regulated kinases 1/2.	decamethrin	12-24	mitogen activated protein kinase 3	Rattus norvegicus	264-306
16166269-7	2006	In addition, administration of deltamethrin to rats increased the level of BDNF protein in the cerebral cortex and hippocampus.	decamethrin	31-43	brain-derived neurotrophic factor	Rattus norvegicus	75-79
16166269-8	2006	These results indicate that deltamethrin is a potent inducer of BDNF expression in neurons and that it may induce neuronal hyperexcitation if it reaches the brain.	decamethrin	28-40	brain-derived neurotrophic factor	Rattus norvegicus	64-68
16758951-0	2006	[Time course of gene expression of gamma-glutamylcysteine synthetase subunit and Nrf2 in brain tissues of rats exposed by deltamethrin].	decamethrin	122-134	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	35-68
16758951-0	2006	[Time course of gene expression of gamma-glutamylcysteine synthetase subunit and Nrf2 in brain tissues of rats exposed by deltamethrin].	decamethrin	122-134	NFE2 like bZIP transcription factor 2	Rattus norvegicus	81-85
16758951-6	2006	RESULTS: (1) At 5 and 48h after DM exposure, GCSh mRNA relative levels in cerebral cortex in rats were significantly decreased to 83.9% and 86.0% of mRNA level of corresponding tissue of control group at Oh, respectively (P < 0.05).	decamethrin	32-34	glycine cleavage system protein H	Rattus norvegicus	45-49
16758951-7	2006	At 5, 24 and 48h after DM exposure, transcriptional factors Nrf2 mRNA relative levels were more higher than those of both control and 72 h group and increased to 146.4%, 145.2% and 147.9% of those of control group at Oh,respectively (P < 0.05).	decamethrin	23-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	60-64
16758951-8	2006	(2) At 5 and 48h after DM exposure, GCSh mRNA relative levels in hippocampus were significantly increased to 118.4% and 118.4% of those of control group at 0h, respectively (P < 0.05).	decamethrin	23-25	glycine cleavage system protein H	Rattus norvegicus	36-40
16758951-10	2006	CONCLUSION: After single dose of DM exposure, there are up-regulation of mRNA expression of both GCSh and GCSl gene in rats hippocampus, down-regulation of mRNA expression of GCSh gene and up-regulation of mRNA expression of Nrf2.	decamethrin	33-35	glycine cleavage system protein H	Rattus norvegicus	97-101
16758951-10	2006	CONCLUSION: After single dose of DM exposure, there are up-regulation of mRNA expression of both GCSh and GCSl gene in rats hippocampus, down-regulation of mRNA expression of GCSh gene and up-regulation of mRNA expression of Nrf2.	decamethrin	33-35	glycine cleavage system protein H	Rattus norvegicus	175-179
16758951-10	2006	CONCLUSION: After single dose of DM exposure, there are up-regulation of mRNA expression of both GCSh and GCSl gene in rats hippocampus, down-regulation of mRNA expression of GCSh gene and up-regulation of mRNA expression of Nrf2.	decamethrin	33-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	225-229
16673815-0	2006	Tyrosine hydroxylase as a target for deltamethrin in the nigrostriatal dopaminergic pathway.	decamethrin	37-49	tyrosine hydroxylase	Rattus norvegicus	0-20
16673815-1	2006	OBJECTIVE: To study the effects of deltamethrin on tyrosine hydroxylase in nigrostriatum of male rats.	decamethrin	35-47	tyrosine hydroxylase	Rattus norvegicus	51-71
16431283-1	2006	In a previous study, we showed that two alternative exons (G1 and G2 encoding IIIS3-S4) were involved in the differential sensitivity of two cockroach sodium channel splice variants, BgNa(v)1-1 and BgNa(v)2-1 (previously called KD1 and KD2), to deltamethrin, a pyrethroid insecticide (Tan, et al., 2002b.	decamethrin	245-257	immunoglobulin kappa variable 1-5	Homo sapiens	183-193
16431283-6	2006	Replacement of A1356 in BgNa(v)2-1 with the corresponding V1356 in BgNa(v)1-1 enhanced the sensitivity of the BgNa(v)2-1 channel to deltamethrin by six-fold.	decamethrin	132-144	immunoglobulin kappa variable 1-5	Homo sapiens	67-77
16431283-7	2006	Conversely, substitution of V1356 with A1356 in BgNa(v)1-1 produced a recombinant BgNa(v)1-1 channel that was 5-fold more resistant to deltamethrin.	decamethrin	135-147	immunoglobulin kappa variable 1-5	Homo sapiens	48-58
16431283-7	2006	Conversely, substitution of V1356 with A1356 in BgNa(v)1-1 produced a recombinant BgNa(v)1-1 channel that was 5-fold more resistant to deltamethrin.	decamethrin	135-147	immunoglobulin kappa variable 1-5	Homo sapiens	82-92
16310970-5	2006	Recent studies in vivo and in vitro have shown that the inducible effect of deltamethrin on brain-derived neurotrophic factor (BDNF) gene expression is very potent and tends to be sustained.	decamethrin	76-88	brain derived neurotrophic factor	Homo sapiens	127-131
16310970-6	2006	With recent evidence that the activation of the BDNF-dependent pathway plays an important role in the mechanism of antidepressant therapeutic action, deltamethrin or derivatives thereof could have potential antidepressant therapeutic effects.	decamethrin	150-162	brain derived neurotrophic factor	Homo sapiens	48-52
15555316-0	2004	[Effects of deltamethrin on the apoptosis and the expression of caspase-3 in rat neural cells].	decamethrin	12-24	caspase 3	Rattus norvegicus	64-73
16325806-6	2005	Human Nav1.8 was resistant to tetrodotoxin and activated by the pyrethroid toxin deltamethrin.	decamethrin	81-93	sodium voltage-gated channel alpha subunit 10	Homo sapiens	6-12
16325806-7	2005	Both voltage-activated and deltamethrin-activated human Nav1.8 were inhibited by the sodium channel blockers BIII 890 CL, NW-1029, and mexiletine.	decamethrin	27-39	sodium voltage-gated channel alpha subunit 10	Homo sapiens	56-62
16105448-11	2005	CONCLUSION: The oxidative stress in nerve tissue, which could be resulted from effect of DM on the activity of SOD, gamma-GCS and GR and GSH content, is one of the mechanisms of neuro-toxicity induced by DM; The decreased activity of gamma-GCS and GR may be the primary cause of DM-induced decrease in that GSH content in hippocampus tissue.	decamethrin	89-91	superoxide dismutase 1	Rattus norvegicus	111-114
16105448-11	2005	CONCLUSION: The oxidative stress in nerve tissue, which could be resulted from effect of DM on the activity of SOD, gamma-GCS and GR and GSH content, is one of the mechanisms of neuro-toxicity induced by DM; The decreased activity of gamma-GCS and GR may be the primary cause of DM-induced decrease in that GSH content in hippocampus tissue.	decamethrin	204-206	superoxide dismutase 1	Rattus norvegicus	111-114
16105448-11	2005	CONCLUSION: The oxidative stress in nerve tissue, which could be resulted from effect of DM on the activity of SOD, gamma-GCS and GR and GSH content, is one of the mechanisms of neuro-toxicity induced by DM; The decreased activity of gamma-GCS and GR may be the primary cause of DM-induced decrease in that GSH content in hippocampus tissue.	decamethrin	204-206	superoxide dismutase 1	Rattus norvegicus	111-114
15555316-1	2004	OBJECTIVE: To study the effect of deltamethrin on the apoptotic rate and the expression of caspase-3 in rat neural cells.	decamethrin	34-46	caspase 3	Rattus norvegicus	91-100
15555316-5	2004	CONCLUSION: Exposure to high dose of deltamethrin would affect the apoptosis, the activity and expression of caspase-3 in rat neural cells.	decamethrin	37-49	caspase 3	Rattus norvegicus	109-118
14761486-2	2003	METHOD: The coupled enzyme ultraviolet spectrophotography was applied to observe the effects of deltamethrin (DM) and permethrin (PM) on the activities of GABAT in rat cerebral cortex, hippocampus, corpus striatum and cerebellum in vitro and in vivo.	decamethrin	96-108	4-aminobutyrate aminotransferase	Rattus norvegicus	155-160
15337272-3	2004	Perfusion of oocytes with either cyclosporin A or deltamethrin, considered to be diagnostic inhibitors of the protein phosphatase calcineurin, at 10 microM blocked spontaneous downregulation.	decamethrin	50-62	protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog	Xenopus laevis	130-141
14769548-5	2004	In contrast, the type II pyrethroids deltamethrin and fenvalerate evoked direct depolarization of Na(v)1.8-F-11 and Na(v)1.5-293-EBNA cells.	decamethrin	37-49	neuron navigator 1	Rattus norvegicus	98-104
14769548-5	2004	In contrast, the type II pyrethroids deltamethrin and fenvalerate evoked direct depolarization of Na(v)1.8-F-11 and Na(v)1.5-293-EBNA cells.	decamethrin	37-49	sodium voltage-gated channel alpha subunit 5	Rattus norvegicus	116-124
14769548-6	2004	Deltamethrin potentiated the veratridine-evoked response in Na(v)1.8-F-11 cells by > or =20-fold, in contrast to a <or =3-fold potentiation of the response in Na(v)1.2a, and Na(v)1.5 cells.	decamethrin	0-12	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	60-68
14769548-6	2004	Deltamethrin potentiated the veratridine-evoked response in Na(v)1.8-F-11 cells by > or =20-fold, in contrast to a <or =3-fold potentiation of the response in Na(v)1.2a, and Na(v)1.5 cells.	decamethrin	0-12	neuron navigator 1	Rattus norvegicus	60-66
14761486-2	2003	METHOD: The coupled enzyme ultraviolet spectrophotography was applied to observe the effects of deltamethrin (DM) and permethrin (PM) on the activities of GABAT in rat cerebral cortex, hippocampus, corpus striatum and cerebellum in vitro and in vivo.	decamethrin	110-112	4-aminobutyrate aminotransferase	Rattus norvegicus	155-160
14761486-4	2003	When 37.5 mg/kg DM and 600 mg/kg PM were orally administrated to the rats at one time, the activities of GABAT in rat cerebral cortex, hippocampus and cerebellum in the DM group [(2.96 +/- 0.43), (2.13 +/-0.44), (5.12 +/- 1.36) nmol x mg pro(-1) x min(-1), respectively] were lower than those in the control group [(3.43 +/- 0.41), (2.68 +/- 0.47), (6.74 +/- 1.64) nmol x mg pro(-1) x min(-1)] (P < 0.05), and the activities of GABAT in rat cerebral cortex and hippocampus in the PM group [(4.57 +/- 0.30), (4.18 +/- 0.63) nmol.mg pro(-1) x min(-1), respectively] were higher than those in the control group (P < 0.05).	decamethrin	16-18	4-aminobutyrate aminotransferase	Rattus norvegicus	105-110
14761486-4	2003	When 37.5 mg/kg DM and 600 mg/kg PM were orally administrated to the rats at one time, the activities of GABAT in rat cerebral cortex, hippocampus and cerebellum in the DM group [(2.96 +/- 0.43), (2.13 +/-0.44), (5.12 +/- 1.36) nmol x mg pro(-1) x min(-1), respectively] were lower than those in the control group [(3.43 +/- 0.41), (2.68 +/- 0.47), (6.74 +/- 1.64) nmol x mg pro(-1) x min(-1)] (P < 0.05), and the activities of GABAT in rat cerebral cortex and hippocampus in the PM group [(4.57 +/- 0.30), (4.18 +/- 0.63) nmol.mg pro(-1) x min(-1), respectively] were higher than those in the control group (P < 0.05).	decamethrin	16-18	4-aminobutyrate aminotransferase	Rattus norvegicus	431-436
14761486-4	2003	When 37.5 mg/kg DM and 600 mg/kg PM were orally administrated to the rats at one time, the activities of GABAT in rat cerebral cortex, hippocampus and cerebellum in the DM group [(2.96 +/- 0.43), (2.13 +/-0.44), (5.12 +/- 1.36) nmol x mg pro(-1) x min(-1), respectively] were lower than those in the control group [(3.43 +/- 0.41), (2.68 +/- 0.47), (6.74 +/- 1.64) nmol x mg pro(-1) x min(-1)] (P < 0.05), and the activities of GABAT in rat cerebral cortex and hippocampus in the PM group [(4.57 +/- 0.30), (4.18 +/- 0.63) nmol.mg pro(-1) x min(-1), respectively] were higher than those in the control group (P < 0.05).	decamethrin	169-171	4-aminobutyrate aminotransferase	Rattus norvegicus	105-110
12628584-5	2003	Western blot analysis demonstrated that p53 and Bax expression were dramatically increased at the same time points, whereas Bcl-2 expression was significantly reduced at all time points after deltamethrin treatment.	decamethrin	192-204	BCL2 apoptosis regulator	Homo sapiens	124-129
12628584-6	2003	Further, we found that nitric oxide synthase inhibitor N(G)-nitro-L-arginine prevented deltamethrin-induced neuronal apoptosis and altered expression of p53, Bax, and Bcl-2.	decamethrin	87-99	BCL2 associated X, apoptosis regulator	Homo sapiens	158-161
12628584-6	2003	Further, we found that nitric oxide synthase inhibitor N(G)-nitro-L-arginine prevented deltamethrin-induced neuronal apoptosis and altered expression of p53, Bax, and Bcl-2.	decamethrin	87-99	BCL2 apoptosis regulator	Homo sapiens	167-172
12760793-0	2003	[Brain-derived neurotrophic factor mRNA expressions in rat brain induced by short-term in vivo exposure to deltamethrin].	decamethrin	107-119	brain-derived neurotrophic factor	Rattus norvegicus	1-34
12573543-0	2003	Prolonged expression of c-Fos and c-Jun in the cerebral cortex of rats after deltamethrin treatment.	decamethrin	77-89	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	24-29
12573543-1	2003	In this study we investigated the effects of deltamethrin on the expression of c-Fos and c-Jun in the cerebral cortex of rats.	decamethrin	45-57	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	79-84
12573543-2	2003	Immunohistochemical analysis demonstrated that the immunoreactivity for c-Fos was markedly increased in the cerebral cortex 5 h after deltamethrin treatment, and maintained at an increased level at 24 h, even though little immunoreactivity for c-Fos was seen in the same brain region of control rats.	decamethrin	134-146	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	72-77
12573543-2	2003	Immunohistochemical analysis demonstrated that the immunoreactivity for c-Fos was markedly increased in the cerebral cortex 5 h after deltamethrin treatment, and maintained at an increased level at 24 h, even though little immunoreactivity for c-Fos was seen in the same brain region of control rats.	decamethrin	134-146	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	244-249
12573543-5	2003	Since the persistent expression of c-Fos and c-Jun is unusual, and has been reported before in conditions involving neurodegeneration, our results are consistent with a model that deltamethrin induces neurodegeneration through a glutamate-dependent pathway.	decamethrin	180-192	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-40
11931506-5	2002	GSH-Px, Cu-Zn SOD and catalase activities in erythrocytes were decreased at high doses of deltamethrin, especially at the high dose (7.5 mg/kg) deltamethrin group.	decamethrin	90-102	superoxide dismutase 1, soluble	Mus musculus	8-17
12191872-4	2002	95th per thousand for cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (DBCA), a specific metabolite of deltamethrin, and 4-fluoro-3-phenoxybenzoic acid (F-PBA), a metabolite of cyfluthrin, were 0.3 and 0.27 microg/l, respectively.	decamethrin	123-135	suppressor of cytokine signaling 3	Homo sapiens	22-27
12497971-7	2002	However, when the impregnated nets were soaked for 30-60 min and washed with soap powder and tap water by local women in the usual way, the mortality after 4 washes declined considerably (43.5% and 41.3% for deltamethrin tablets and liquid respectively when washing every second day).	decamethrin	208-220	nuclear RNA export factor 1	Homo sapiens	93-96
11502895-2	2001	Deltamethrin at 10 microM elicited weak gating changes in rat skeletal muscle alpha-subunit Na(+) channels (Nav1.4) after > 30 min of perfusion.	decamethrin	0-12	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	108-114
11502895-4	2001	A background mutation, Nav1.4-I687M (within D2:S4-S5 cytoplasmic linker), enhanced the deltamethrin-induced maintained current by approximately 2.5-fold, whereas Nav1.4-I687T, a homologous superkdr mutation, reduced it by approximately 2-fold.	decamethrin	87-99	neuron navigator 1	Homo sapiens	23-27
11502895-4	2001	A background mutation, Nav1.4-I687M (within D2:S4-S5 cytoplasmic linker), enhanced the deltamethrin-induced maintained current by approximately 2.5-fold, whereas Nav1.4-I687T, a homologous superkdr mutation, reduced it by approximately 2-fold.	decamethrin	87-99	sodium voltage-gated channel alpha subunit 4	Homo sapiens	23-29
11502895-5	2001	Repetitive pulses at 2 Hz further augmented the effects of deltamethrin on Nav1.4-I687M mutant channels so that approximately 75% of peak currents were maintained.	decamethrin	59-71	sodium voltage-gated channel alpha subunit 4	Homo sapiens	75-81
11502895-6	2001	A second mutation, Nav1.4-I687M/F1278I at the middle of D3-S6, rendered the channel greatly resistant to deltamethrin.	decamethrin	105-117	neuron navigator 1	Homo sapiens	19-23
11502895-9	2001	Another mutant, Nav1.4-I687M/N784K, exhibited a partial deltamethrin-resistant phenotype but was completely resistant to BTX.	decamethrin	56-68	neuron navigator 1	Homo sapiens	16-20
14715465-1	2001	Oral administration of 5 mg/kg body weight of deltamethrin, an alpha-cyano type II pyrethroid insecticide once a day for 1, 7, 15 and 21 consecutive days to young Druckerey rats (6- 8 weeks old) produced a time dependent increase in the activity of cytochrome P450 (P450) dependent 7-ethoxyresorufin-O-deethylase (EROD) and 7-pentoxyresorufin-O-dealkylase (PROD) in rat brain microsomes.	decamethrin	46-58	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	249-312
11410192-3	2001	We aimed to investigate whether domestic livestock treated with deltamethrin (applied by a sponging method) would prove toxic to mosquitoes and therefore aid in malaria control.	decamethrin	64-76	activation induced cytidine deaminase	Homo sapiens	154-157
10771154-5	2000	These results indicate that deltamethrin leads to the persistent increase of P53 and Bax expression and transient elevation of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which may contribute to apoptotic cell death in rat brain following deltamethrin treatment.	decamethrin	262-274	BCL2 associated X, apoptosis regulator	Rattus norvegicus	180-183
10771154-0	2000	Deltamethrin induces altered expression of P53, Bax and Bcl-2 in rat brain.	decamethrin	0-12	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	43-46
11226636-3	2001	The significant increase in acetylcholinesterase activity and decrease in (3)H-quinuclidinyl benzilate binding in the hippocampal region of DT exposed animals, suggesting impairment in cholinergic (muscarinic) receptors.	decamethrin	140-142	acetylcholinesterase	Rattus norvegicus	28-48
11226636-5	2001	Immunohistochemistry and image analysis of growth associated protein-43, a neuron specific protein present in axonal growth cone and a marker for neuronal differentiation and synaptogenesis, exhibit aberrant increase in its expression in the hippocampus in DT exposed rats at both time periods.	decamethrin	257-259	growth associated protein 43	Rattus norvegicus	43-71
10925071-0	2000	Deltamethrin induces delayed apoptosis and altered expression of p53 and bax in rat brain.	decamethrin	0-12	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	65-68
10771154-0	2000	Deltamethrin induces altered expression of P53, Bax and Bcl-2 in rat brain.	decamethrin	0-12	BCL2 associated X, apoptosis regulator	Rattus norvegicus	48-51
10771154-0	2000	Deltamethrin induces altered expression of P53, Bax and Bcl-2 in rat brain.	decamethrin	0-12	BCL2, apoptosis regulator	Rattus norvegicus	56-61
10771154-1	2000	In this study we investigated the effects of deltamethrin on the expression of P53, Bax and Bcl-2 in rat brain.	decamethrin	45-57	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	79-82
10771154-1	2000	In this study we investigated the effects of deltamethrin on the expression of P53, Bax and Bcl-2 in rat brain.	decamethrin	45-57	BCL2 associated X, apoptosis regulator	Rattus norvegicus	84-87
10771154-1	2000	In this study we investigated the effects of deltamethrin on the expression of P53, Bax and Bcl-2 in rat brain.	decamethrin	45-57	BCL2, apoptosis regulator	Rattus norvegicus	92-97
10771154-2	2000	Immunohistochemical analysis demonstrated that the immunoreactivity for P53 was markedly increased in the cerebral cortex and hippocampus at 5 h after deltamethrin treatment, and maintained at an increased level at 24 and 48 h, whereas little immunoreactivity for P53 was seen in the same brain regions of control rats.	decamethrin	151-163	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	72-75
10771154-3	2000	The immunostaining for Bax was also elevated in the same brain regions, showing the same time course of P53 expression after deltamethrin treatment.	decamethrin	125-137	BCL2 associated X, apoptosis regulator	Rattus norvegicus	23-26
10771154-4	2000	However, the immunolabeling for Bcl-2 was markedly decreased at 24 h after a transient increase at 5 h following deltamethrin treatment.	decamethrin	113-125	BCL2, apoptosis regulator	Rattus norvegicus	32-37
10771154-5	2000	These results indicate that deltamethrin leads to the persistent increase of P53 and Bax expression and transient elevation of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which may contribute to apoptotic cell death in rat brain following deltamethrin treatment.	decamethrin	28-40	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	77-80
10771154-5	2000	These results indicate that deltamethrin leads to the persistent increase of P53 and Bax expression and transient elevation of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which may contribute to apoptotic cell death in rat brain following deltamethrin treatment.	decamethrin	28-40	BCL2 associated X, apoptosis regulator	Rattus norvegicus	85-88
10771154-5	2000	These results indicate that deltamethrin leads to the persistent increase of P53 and Bax expression and transient elevation of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which may contribute to apoptotic cell death in rat brain following deltamethrin treatment.	decamethrin	28-40	BCL2, apoptosis regulator	Rattus norvegicus	127-132
10771154-5	2000	These results indicate that deltamethrin leads to the persistent increase of P53 and Bax expression and transient elevation of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which may contribute to apoptotic cell death in rat brain following deltamethrin treatment.	decamethrin	28-40	BCL2 associated X, apoptosis regulator	Rattus norvegicus	180-183
10771154-5	2000	These results indicate that deltamethrin leads to the persistent increase of P53 and Bax expression and transient elevation of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which may contribute to apoptotic cell death in rat brain following deltamethrin treatment.	decamethrin	28-40	BCL2, apoptosis regulator	Rattus norvegicus	187-192
10925071-6	2000	The alterations in mRNA expression of p53 and bax preceded the occurrence of delayed apoptotic cell death in the same brain regions after deltamethrin treatment.	decamethrin	138-150	BCL2 associated X, apoptosis regulator	Rattus norvegicus	46-49
10925071-7	2000	These results indicate that (1) deltamethrin induces delayed apoptotic cell death, which may play an important role in deltamethrin-elicited neurodegeneration; (2) deltamethrin leads to the persistent increase of p53 and bax mRNA levels, which may contribute to delayed apoptosis in rat brain following deltamethrin treatment.	decamethrin	32-44	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	213-216
10925071-7	2000	These results indicate that (1) deltamethrin induces delayed apoptotic cell death, which may play an important role in deltamethrin-elicited neurodegeneration; (2) deltamethrin leads to the persistent increase of p53 and bax mRNA levels, which may contribute to delayed apoptosis in rat brain following deltamethrin treatment.	decamethrin	32-44	BCL2 associated X, apoptosis regulator	Rattus norvegicus	221-224
10925071-7	2000	These results indicate that (1) deltamethrin induces delayed apoptotic cell death, which may play an important role in deltamethrin-elicited neurodegeneration; (2) deltamethrin leads to the persistent increase of p53 and bax mRNA levels, which may contribute to delayed apoptosis in rat brain following deltamethrin treatment.	decamethrin	119-131	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	213-216
10925071-7	2000	These results indicate that (1) deltamethrin induces delayed apoptotic cell death, which may play an important role in deltamethrin-elicited neurodegeneration; (2) deltamethrin leads to the persistent increase of p53 and bax mRNA levels, which may contribute to delayed apoptosis in rat brain following deltamethrin treatment.	decamethrin	119-131	BCL2 associated X, apoptosis regulator	Rattus norvegicus	221-224
10925071-7	2000	These results indicate that (1) deltamethrin induces delayed apoptotic cell death, which may play an important role in deltamethrin-elicited neurodegeneration; (2) deltamethrin leads to the persistent increase of p53 and bax mRNA levels, which may contribute to delayed apoptosis in rat brain following deltamethrin treatment.	decamethrin	119-131	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	213-216
10925071-7	2000	These results indicate that (1) deltamethrin induces delayed apoptotic cell death, which may play an important role in deltamethrin-elicited neurodegeneration; (2) deltamethrin leads to the persistent increase of p53 and bax mRNA levels, which may contribute to delayed apoptosis in rat brain following deltamethrin treatment.	decamethrin	119-131	BCL2 associated X, apoptosis regulator	Rattus norvegicus	221-224
10925071-7	2000	These results indicate that (1) deltamethrin induces delayed apoptotic cell death, which may play an important role in deltamethrin-elicited neurodegeneration; (2) deltamethrin leads to the persistent increase of p53 and bax mRNA levels, which may contribute to delayed apoptosis in rat brain following deltamethrin treatment.	decamethrin	119-131	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	213-216
10925071-7	2000	These results indicate that (1) deltamethrin induces delayed apoptotic cell death, which may play an important role in deltamethrin-elicited neurodegeneration; (2) deltamethrin leads to the persistent increase of p53 and bax mRNA levels, which may contribute to delayed apoptosis in rat brain following deltamethrin treatment.	decamethrin	119-131	BCL2 associated X, apoptosis regulator	Rattus norvegicus	221-224
10925071-0	2000	Deltamethrin induces delayed apoptosis and altered expression of p53 and bax in rat brain.	decamethrin	0-12	BCL2 associated X, apoptosis regulator	Rattus norvegicus	73-76
10925071-2	2000	To determine whether molecular characteristics of apoptosis is involved in neurodegeneration in rat brain after deltamethrin treatment, we investigated the effects of deltamethrin on the mRNA expression of p53 and bax and their correlation with deltamethrin-induced apoptotic cell death in rat brain.	decamethrin	167-179	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	206-209
10925071-2	2000	To determine whether molecular characteristics of apoptosis is involved in neurodegeneration in rat brain after deltamethrin treatment, we investigated the effects of deltamethrin on the mRNA expression of p53 and bax and their correlation with deltamethrin-induced apoptotic cell death in rat brain.	decamethrin	167-179	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	206-209
10925071-6	2000	The alterations in mRNA expression of p53 and bax preceded the occurrence of delayed apoptotic cell death in the same brain regions after deltamethrin treatment.	decamethrin	138-150	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	38-41
10629771-5	1999	These results indicate that deltamethrin increases the activities of NOS and PARP and initiates the protein expression of nNOS and PARP, suggesting that NOS and PARP might play important roles in neurotoxicity of deltamethrin.	decamethrin	213-225	poly (ADP-ribose) polymerase 1	Rattus norvegicus	77-81
10844399-11	2000	After incubation of the cells with deltamethrin, a calcineurin inhibitor, the stimulation of secretion was attenuated, but the adrenaline-induced inhibition was not affected.	decamethrin	35-47	calcineurin binding protein 1	Rattus norvegicus	51-72
10629771-5	1999	These results indicate that deltamethrin increases the activities of NOS and PARP and initiates the protein expression of nNOS and PARP, suggesting that NOS and PARP might play important roles in neurotoxicity of deltamethrin.	decamethrin	213-225	nitric oxide synthase 1	Rattus norvegicus	122-126
10629771-0	1999	Effects of deltamethrin on nitric oxide synthase and poly(ADP-ribose) polymerase in rat brain.	decamethrin	11-23	poly (ADP-ribose) polymerase 1	Rattus norvegicus	53-80
10629771-1	1999	The effects of deltamethrin on the activities of nitric oxide synthase (NOS) and poly(ADP-ribose) polymerase (PARP) and the protein expression of neuronal NOS (nNOS) and PARP in rat brain were investigated in the present study.	decamethrin	15-27	poly (ADP-ribose) polymerase 1	Rattus norvegicus	81-108
10629771-1	1999	The effects of deltamethrin on the activities of nitric oxide synthase (NOS) and poly(ADP-ribose) polymerase (PARP) and the protein expression of neuronal NOS (nNOS) and PARP in rat brain were investigated in the present study.	decamethrin	15-27	poly (ADP-ribose) polymerase 1	Rattus norvegicus	110-114
10629771-2	1999	The activity of NOS was significantly increased in cortex and hippocampus at 5 h after deltamethrin treatment, and maintained at an increased level at 24 h. The activity of PARP was also elevated at the same time points in the same brain regions of treated rats.	decamethrin	87-99	poly (ADP-ribose) polymerase 1	Rattus norvegicus	173-177
10629771-4	1999	The immunoreactivity for PARP was also increased in the same brain regions, showing the similar time course of the induction of nNOS by deltamethrin.	decamethrin	136-148	poly (ADP-ribose) polymerase 1	Rattus norvegicus	25-29
10629771-4	1999	The immunoreactivity for PARP was also increased in the same brain regions, showing the similar time course of the induction of nNOS by deltamethrin.	decamethrin	136-148	nitric oxide synthase 1	Rattus norvegicus	128-132
10629771-5	1999	These results indicate that deltamethrin increases the activities of NOS and PARP and initiates the protein expression of nNOS and PARP, suggesting that NOS and PARP might play important roles in neurotoxicity of deltamethrin.	decamethrin	28-40	poly (ADP-ribose) polymerase 1	Rattus norvegicus	77-81
10629771-5	1999	These results indicate that deltamethrin increases the activities of NOS and PARP and initiates the protein expression of nNOS and PARP, suggesting that NOS and PARP might play important roles in neurotoxicity of deltamethrin.	decamethrin	28-40	nitric oxide synthase 1	Rattus norvegicus	122-126
10629771-5	1999	These results indicate that deltamethrin increases the activities of NOS and PARP and initiates the protein expression of nNOS and PARP, suggesting that NOS and PARP might play important roles in neurotoxicity of deltamethrin.	decamethrin	28-40	poly (ADP-ribose) polymerase 1	Rattus norvegicus	131-135
10629771-5	1999	These results indicate that deltamethrin increases the activities of NOS and PARP and initiates the protein expression of nNOS and PARP, suggesting that NOS and PARP might play important roles in neurotoxicity of deltamethrin.	decamethrin	28-40	poly (ADP-ribose) polymerase 1	Rattus norvegicus	131-135
10629771-5	1999	These results indicate that deltamethrin increases the activities of NOS and PARP and initiates the protein expression of nNOS and PARP, suggesting that NOS and PARP might play important roles in neurotoxicity of deltamethrin.	decamethrin	213-225	poly (ADP-ribose) polymerase 1	Rattus norvegicus	131-135
10629771-5	1999	These results indicate that deltamethrin increases the activities of NOS and PARP and initiates the protein expression of nNOS and PARP, suggesting that NOS and PARP might play important roles in neurotoxicity of deltamethrin.	decamethrin	213-225	poly (ADP-ribose) polymerase 1	Rattus norvegicus	131-135
9594016-2	1998	Treating CFTR-expressing 3T3 cells with either of the two specific PP2B blockers cyclosporin A (CsA, 1 microM) or deltamethrin (DM, 30 nM) caused rapid activation of CFTR in cell-attached patches.	decamethrin	114-126	cystic fibrosis transmembrane conductance regulator	Mus musculus	9-13
21781923-0	1999	Induction of rat brain and liver cytochrome P450 1A1/1A2 and 2B1/2B2 isoenzymes by deltamethrin.	decamethrin	83-95	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	33-68
9755112-6	1998	Western immunoblotting revealed PPase 2B to be present in cytoskeletal EC fractions, with specific PPase 2B inhibitors such as cyclosporin (200 nM) and deltamethrin (100 nM to 1 microM) attenuating thrombin-induced cytoskeletal protein dephosphorylation, including EC MLC dephosphorylation.	decamethrin	152-164	inorganic pyrophosphatase 2	Homo sapiens	32-39
9755112-6	1998	Western immunoblotting revealed PPase 2B to be present in cytoskeletal EC fractions, with specific PPase 2B inhibitors such as cyclosporin (200 nM) and deltamethrin (100 nM to 1 microM) attenuating thrombin-induced cytoskeletal protein dephosphorylation, including EC MLC dephosphorylation.	decamethrin	152-164	coagulation factor II, thrombin	Homo sapiens	198-206
9594016-2	1998	Treating CFTR-expressing 3T3 cells with either of the two specific PP2B blockers cyclosporin A (CsA, 1 microM) or deltamethrin (DM, 30 nM) caused rapid activation of CFTR in cell-attached patches.	decamethrin	114-126	cystic fibrosis transmembrane conductance regulator	Mus musculus	166-170
9594016-2	1998	Treating CFTR-expressing 3T3 cells with either of the two specific PP2B blockers cyclosporin A (CsA, 1 microM) or deltamethrin (DM, 30 nM) caused rapid activation of CFTR in cell-attached patches.	decamethrin	128-130	cystic fibrosis transmembrane conductance regulator	Mus musculus	9-13
9594016-2	1998	Treating CFTR-expressing 3T3 cells with either of the two specific PP2B blockers cyclosporin A (CsA, 1 microM) or deltamethrin (DM, 30 nM) caused rapid activation of CFTR in cell-attached patches.	decamethrin	128-130	cystic fibrosis transmembrane conductance regulator	Mus musculus	166-170
9594016-3	1998	As determined by noise analysis of multi channel patches, DM- or CsA-activated CFTR displayed gating kinetics comparable to those of forskolin-activated CFTR.	decamethrin	58-60	cystic fibrosis transmembrane conductance regulator	Mus musculus	79-83
9379408-18	1997	The calcineurin-stimulated decrease of Po,peak in cells co-transfected with C alpha-PKA is blocked by 800 nM deltamethrin, a calcineurin inhibitor.	decamethrin	109-121	calcineurin binding protein 1	Homo sapiens	125-146
9572286-7	1998	Deltamethrin (20 nM), another calcineurin inhibitor, had a similar protective effect, whereas okadaic acid did not.	decamethrin	0-12	calcineurin binding protein 1	Rattus norvegicus	30-51
9461846-4	1997	Moreover, immunoblotting responses of microsomal protein encoded by Cyp6A2 showed that the levels of expression were quantitatively correlated with toxicological tolerance to almost the same group of insecticides (deltamethrin, fipronil, chlorpyriphos ethyl, DDT, fenvalerate, and fenthion).	decamethrin	214-226	Cytochrome P450-6a2	Drosophila melanogaster	68-74
9004471-3	1997	The highest residues in milk were found on day 28 for flumethrin and day 1 for deltamethrin, cypermethrin and cyhalothrin, while in blood the highest concentrations were present on day 28 for flumethrin and deltamethrin, the first day for cypermethrin, and day 14 for cyhalothrin.	decamethrin	79-91	Weaning weight-maternal milk	Bos taurus	24-28
8619889-8	1996	In addition, deltamethrin-1R induced a transient increase of [Ca2+]i mobilization in the thymocyte suspension after 10 min of in vitro treatment, and substantially reduced the rate of calcium-calmodulin (Ca/CaM)-dependent protein dephosphorylation in in vivo treated animals (25 mg deltamethrin/kg for 24 hr).	decamethrin	13-25	calmodulin 2	Mus musculus	192-202
8917670-14	1996	Considerable concentrations of deltamethrin and 4"-HO-deltamethrin were found in the hypothalamus, cerebellum, frontal cortex, caudate putamen, hippocampus, medulla oblongata, vas deferens, and anococcygeus tissues.	decamethrin	31-43	arginine vasopressin	Rattus norvegicus	176-179
8917670-15	1996	The elimination half-lives (t1/2 el) for both deltamethrin and 4"-HO-deltamethrin were somewhat smaller for the cerebellum, frontal cortex, caudate putamen, medulla oblongata, vas deferens, and anococcygeus tissues (range, 18-33 hr for deltamethrin and 15-28 hr for 4"-HO-deltamethrin) than for plasma (t1/2 el, 38.50 and 30.13 hr, respectively).	decamethrin	46-58	arginine vasopressin	Rattus norvegicus	176-179
8917670-15	1996	The elimination half-lives (t1/2 el) for both deltamethrin and 4"-HO-deltamethrin were somewhat smaller for the cerebellum, frontal cortex, caudate putamen, medulla oblongata, vas deferens, and anococcygeus tissues (range, 18-33 hr for deltamethrin and 15-28 hr for 4"-HO-deltamethrin) than for plasma (t1/2 el, 38.50 and 30.13 hr, respectively).	decamethrin	69-81	arginine vasopressin	Rattus norvegicus	176-179
8619889-12	1996	In addition, the involvement of the Ca/CaM-dependent protein phosphorylation-dephosphorylation cascade in the induction of apoptosis by deltamethrin was supported by the protective role of the calmodulin inhibitor trifluoperazine against the apoptotic effect of deltamethrin on thymocyte suspension.	decamethrin	136-148	calmodulin 2	Mus musculus	193-203
8619889-12	1996	In addition, the involvement of the Ca/CaM-dependent protein phosphorylation-dephosphorylation cascade in the induction of apoptosis by deltamethrin was supported by the protective role of the calmodulin inhibitor trifluoperazine against the apoptotic effect of deltamethrin on thymocyte suspension.	decamethrin	262-274	calmodulin 2	Mus musculus	193-203
34389319-0	2021	The insecticide deltamethrin enhances sodium channel slow inactivation of human Nav1.9, Nav1.8 and Nav1.7.	decamethrin	16-28	sodium voltage-gated channel alpha subunit 11	Homo sapiens	80-86
34781252-2	2021	Therefore, we used an exponential decay model of deltamethrin depletion to predict the effective insecticidal lifetime of PermaNet  2.0 nets used in the Lao PDR.	decamethrin	49-61	interleukin 4 induced 1	Homo sapiens	153-156
34781252-5	2021	The median total and surface deltamethrin levels for the Lao nets at 12 months were 31.2 and 0.0743 mg/m2, respectively.	decamethrin	29-41	interleukin 4 induced 1	Homo sapiens	57-60
34218375-6	2021	Deltamethrin administration caused an increase in lipid peroxidation level and a decrease in activities of SOD, CAT, GPx, and GSH levels in the both tissues.	decamethrin	0-12	catalase	Rattus norvegicus	112-115
34218375-7	2021	Deltamethrin also increased serum ALT, AST, ALP, urea, and creatinine levels, while reduced nephrine levels in rats.	decamethrin	0-12	PDZ and LIM domain 3	Rattus norvegicus	44-47
34218375-8	2021	In addition, deltamethrin increased the activation of inflammatory and apoptotic pathways by decreasing Bcl-2 and increasing TNF-alpha, NF-kappaB, IL-1beta, p38alpha MAPK, COX-2, iNOS, beclin-1, Bax, and caspase-3 protein levels and/or activities.	decamethrin	13-25	BCL2, apoptosis regulator	Rattus norvegicus	104-109
34218375-8	2021	In addition, deltamethrin increased the activation of inflammatory and apoptotic pathways by decreasing Bcl-2 and increasing TNF-alpha, NF-kappaB, IL-1beta, p38alpha MAPK, COX-2, iNOS, beclin-1, Bax, and caspase-3 protein levels and/or activities.	decamethrin	13-25	tumor necrosis factor	Rattus norvegicus	125-134
34218375-8	2021	In addition, deltamethrin increased the activation of inflammatory and apoptotic pathways by decreasing Bcl-2 and increasing TNF-alpha, NF-kappaB, IL-1beta, p38alpha MAPK, COX-2, iNOS, beclin-1, Bax, and caspase-3 protein levels and/or activities.	decamethrin	13-25	interleukin 1 alpha	Rattus norvegicus	147-155
34218375-8	2021	In addition, deltamethrin increased the activation of inflammatory and apoptotic pathways by decreasing Bcl-2 and increasing TNF-alpha, NF-kappaB, IL-1beta, p38alpha MAPK, COX-2, iNOS, beclin-1, Bax, and caspase-3 protein levels and/or activities.	decamethrin	13-25	mitogen activated protein kinase 14	Rattus norvegicus	157-165
34218375-8	2021	In addition, deltamethrin increased the activation of inflammatory and apoptotic pathways by decreasing Bcl-2 and increasing TNF-alpha, NF-kappaB, IL-1beta, p38alpha MAPK, COX-2, iNOS, beclin-1, Bax, and caspase-3 protein levels and/or activities.	decamethrin	13-25	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	172-177
34218375-8	2021	In addition, deltamethrin increased the activation of inflammatory and apoptotic pathways by decreasing Bcl-2 and increasing TNF-alpha, NF-kappaB, IL-1beta, p38alpha MAPK, COX-2, iNOS, beclin-1, Bax, and caspase-3 protein levels and/or activities.	decamethrin	13-25	nitric oxide synthase 2	Rattus norvegicus	179-183
34218375-8	2021	In addition, deltamethrin increased the activation of inflammatory and apoptotic pathways by decreasing Bcl-2 and increasing TNF-alpha, NF-kappaB, IL-1beta, p38alpha MAPK, COX-2, iNOS, beclin-1, Bax, and caspase-3 protein levels and/or activities.	decamethrin	13-25	beclin 1	Rattus norvegicus	185-193
34218375-8	2021	In addition, deltamethrin increased the activation of inflammatory and apoptotic pathways by decreasing Bcl-2 and increasing TNF-alpha, NF-kappaB, IL-1beta, p38alpha MAPK, COX-2, iNOS, beclin-1, Bax, and caspase-3 protein levels and/or activities.	decamethrin	13-25	BCL2 associated X, apoptosis regulator	Rattus norvegicus	195-198
34218375-8	2021	In addition, deltamethrin increased the activation of inflammatory and apoptotic pathways by decreasing Bcl-2 and increasing TNF-alpha, NF-kappaB, IL-1beta, p38alpha MAPK, COX-2, iNOS, beclin-1, Bax, and caspase-3 protein levels and/or activities.	decamethrin	13-25	caspase 3	Rattus norvegicus	204-213
34218375-9	2021	Furthermore, deltamethrin increased mRNA expression levels of PARP-1, VEGF, and immunohistochemical expressions of c-fos in the tissues.	decamethrin	13-25	poly (ADP-ribose) polymerase 1	Rattus norvegicus	62-68
34218375-9	2021	Furthermore, deltamethrin increased mRNA expression levels of PARP-1, VEGF, and immunohistochemical expressions of c-fos in the tissues.	decamethrin	13-25	vascular endothelial growth factor A	Rattus norvegicus	70-74
34218375-9	2021	Furthermore, deltamethrin increased mRNA expression levels of PARP-1, VEGF, and immunohistochemical expressions of c-fos in the tissues.	decamethrin	13-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	115-120
34389319-0	2021	The insecticide deltamethrin enhances sodium channel slow inactivation of human Nav1.9, Nav1.8 and Nav1.7.	decamethrin	16-28	sodium voltage-gated channel alpha subunit 10	Homo sapiens	88-94
34389319-0	2021	The insecticide deltamethrin enhances sodium channel slow inactivation of human Nav1.9, Nav1.8 and Nav1.7.	decamethrin	16-28	sodium voltage-gated channel alpha subunit 9	Homo sapiens	99-105
35365720-3	2022	Here we investigate transcriptional and behavioral phenotypes in a Chd8 haploinsufficient (Chd8V986*/+) mouse line exposed to the pesticide deltamethrin (DM) from conception to postnatal day 22.	decamethrin	140-152	chromodomain helicase DNA binding protein 8	Mus musculus	67-71
35430070-5	2022	In addition, pretreatment with two AK inhibitors, rutin and quercetin, significantly decreased the lifespan of beetles treated with deltamethrin.	decamethrin	132-144	arginine kinase	Tribolium castaneum	35-37
34203916-6	2021	The results displayed upregulated transcription of catalase, glutathione peroxidase, and interferon (IFN-gamma) genes caused by DMT exposure and synbiotic feeding when compared with the controls.	decamethrin	128-131	catalase	Oreochromis niloticus	51-59
34203916-6	2021	The results displayed upregulated transcription of catalase, glutathione peroxidase, and interferon (IFN-gamma) genes caused by DMT exposure and synbiotic feeding when compared with the controls.	decamethrin	128-131	glutathione peroxidase	Oreochromis niloticus	61-83
34203916-7	2021	Moreover, HSP70 and CASP3 genes displayed increased transcription caused by DMT exposure without synbiotic feeding.	decamethrin	76-79	heat shock cognate 71 kDa protein	Oreochromis niloticus	10-15
34203916-9	2021	The transcription of IL-1beta and IL-8 genes were also decreased by DMT exposure, while fish fed synbiotics showed upregulated levels.	decamethrin	68-71	interleukin-1 beta	Oreochromis niloticus	21-29
34203916-9	2021	The transcription of IL-1beta and IL-8 genes were also decreased by DMT exposure, while fish fed synbiotics showed upregulated levels.	decamethrin	68-71	interleukin-8	Oreochromis niloticus	34-38
35378399-11	2022	Prenatal DM exposures decreased the protein levels of NR2A and NR2B in both hippocampi and cerebral cortices of male offspring.	decamethrin	9-11	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	54-58
35378399-11	2022	Prenatal DM exposures decreased the protein levels of NR2A and NR2B in both hippocampi and cerebral cortices of male offspring.	decamethrin	9-11	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	63-67
35378399-12	2022	However, female mice receiving DM exposure at GD 16-B but not other stages displayed increased expression levels of NR2A and NR2B in hippocampi.	decamethrin	31-33	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	116-120
35378399-12	2022	However, female mice receiving DM exposure at GD 16-B but not other stages displayed increased expression levels of NR2A and NR2B in hippocampi.	decamethrin	31-33	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	125-129
35041849-0	2022	Motor, memory, and anxiety-like behavioral impairments associated with brain-derived neurotrophic factor and dopaminergic imbalance after inhalational exposure to deltamethrin.	decamethrin	163-175	brain-derived neurotrophic factor	Rattus norvegicus	71-104
35125074-0	2022	Interaction of synthetic pyrethroid insecticide deltamethrin with human alpha-2-macroglobulin: Spectroscopic and molecular docking studies.	decamethrin	48-60	alpha-2-macroglobulin	Homo sapiens	72-93
34525687-8	2022	The locomotor activity of eralpha and erbeta knockdown zebrafish following DM exposure was increased significantly when compared with that of larvae exposed to 25 mug/L DM only.	decamethrin	75-77	estrogen receptor 1	Danio rerio	26-33
35056033-6	2022	Deltamethrin administration resulted in (i) a decreased fly population (100% Musca domestica) landing on pre-weaned dairy calves, (ii) a reduced SC (stress indicator) and CK (fatigue indicator) concentration, and (iii) an increased consumption of feedstuff in deltamethrin treated animals compared to the untreated ones.	decamethrin	0-12	cytidine/uridine monophosphate kinase 1	Bos taurus	171-173
34525687-8	2022	The locomotor activity of eralpha and erbeta knockdown zebrafish following DM exposure was increased significantly when compared with that of larvae exposed to 25 mug/L DM only.	decamethrin	75-77	estrogen receptor 1	Danio rerio	38-44
34525687-8	2022	The locomotor activity of eralpha and erbeta knockdown zebrafish following DM exposure was increased significantly when compared with that of larvae exposed to 25 mug/L DM only.	decamethrin	169-171	estrogen receptor 1	Danio rerio	26-33
34525687-8	2022	The locomotor activity of eralpha and erbeta knockdown zebrafish following DM exposure was increased significantly when compared with that of larvae exposed to 25 mug/L DM only.	decamethrin	169-171	estrogen receptor 1	Danio rerio	38-44
2459366-1	1988	It has been demonstrated previously that select Type II pyrethroids are potent proconvulsants in the rat and that the proconvulsant actions of deltamethrin are blocked by administration of PK 11195, an antagonist of the peripheral-type benzodiazepine receptor (PTBR).	decamethrin	143-155	translocator protein	Rattus norvegicus	220-259
2459366-1	1988	It has been demonstrated previously that select Type II pyrethroids are potent proconvulsants in the rat and that the proconvulsant actions of deltamethrin are blocked by administration of PK 11195, an antagonist of the peripheral-type benzodiazepine receptor (PTBR).	decamethrin	143-155	translocator protein	Rattus norvegicus	261-265
2973491-4	1988	AChE activity was increased (P less than 0.01) after 1 month of treatment with the two doses of dimethoate and deltamethrin; thereafter, AChE activity showed 40% inhibition of the control level.	decamethrin	111-123	ACE-1	Oryctolagus cuniculus	0-4
33069802-0	2021	Ran participates in deltamethrin stress through regulating the nuclear import of Nrf2.	decamethrin	20-32	Ran	Drosophila melanogaster	0-3
2434890-9	1986	Although lindane and deltamethrin also altered GABAA receptor-ionophore function, their low potencies and the incomplete stereospecificity of deltamethrin inhibition suggest that this complex is not involved in the neurotoxic action of lindane and alpha-cyano-substituted pyrethroids.	decamethrin	21-33	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	47-52
2423935-2	1986	The pyrethroid-resistant strains kdr and super-kdr, which are thought to have rediced neural sensitivity to pyrethroids, displayed 28-fold and greater than 909-fold resistance to deltamethrin when compared to the pyrethroid-susceptible NAIDM strain.	decamethrin	179-191	sodium channel protein para-like	Musca domestica	33-36
2423935-2	1986	The pyrethroid-resistant strains kdr and super-kdr, which are thought to have rediced neural sensitivity to pyrethroids, displayed 28-fold and greater than 909-fold resistance to deltamethrin when compared to the pyrethroid-susceptible NAIDM strain.	decamethrin	179-191	sodium channel protein para-like	Musca domestica	41-50
2419769-8	1985	These findings also indicate that a degree of selectivity exists in the action of deltamethrin, a sodium channel toxin that might be expected to act on all neuronal systems within the SN or VTN or equally at other sites within the basal ganglia associated with circling behaviour.	decamethrin	82-94	vitronectin	Rattus norvegicus	190-193
4047507-10	1985	Other than in cerebellum, a significant increase in rCBF was of early onset, occurring in animals showing salivation and chewing as the only symptoms after being given deltamethrin.	decamethrin	168-180	CCAAT/enhancer binding protein zeta	Rattus norvegicus	52-56
4004339-0	1985	Crop groupings: a survey of its possibilities for deltamethrin registrations.	decamethrin	50-62	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	0-4
2957417-1	1987	Effects of two classes of pyrethroids, permethrin and resmethrin (type I), cypermethrin and deltamethrin (type II), on basal (calmodulin-deficient) and calmodulin stimulated activities of Ca2+ ATPase and adenylate cyclase from rat brain were studied in vitro.	decamethrin	92-104	calmodulin 1	Rattus norvegicus	152-162
2957417-1	1987	Effects of two classes of pyrethroids, permethrin and resmethrin (type I), cypermethrin and deltamethrin (type II), on basal (calmodulin-deficient) and calmodulin stimulated activities of Ca2+ ATPase and adenylate cyclase from rat brain were studied in vitro.	decamethrin	92-104	carbonic anhydrase 2	Rattus norvegicus	188-199
6314930-4	1983	Significant increases in beta-glucuronidase and beta-galactosidase were found 3-4 weeks after the start of dosing in the distal portion of the sciatic/posterior tibial nerves from permethrin, cypermethrin, and deltamethrin treated animal; but no changes were found in remesthrin-dosed animals.	decamethrin	210-222	glucuronidase, beta	Rattus norvegicus	25-43
6314930-4	1983	Significant increases in beta-glucuronidase and beta-galactosidase were found 3-4 weeks after the start of dosing in the distal portion of the sciatic/posterior tibial nerves from permethrin, cypermethrin, and deltamethrin treated animal; but no changes were found in remesthrin-dosed animals.	decamethrin	210-222	galactosidase, beta 1	Rattus norvegicus	48-66
33652208-7	2021	Apart from modulating the hydrophobic domain, deltamethrin is observed to reduce alpha-helical and promote beta-sheet content of lysozyme, eventually converting the globular protein into ThT sensitive amyloid fibrils and amorphous aggregates.	decamethrin	46-58	lysozyme	Homo sapiens	129-137
33652208-8	2021	Our study also indicate that deltamethrin induced aggregation reduces the catalytic activity of lysozyme.	decamethrin	29-41	lysozyme	Homo sapiens	96-104
33069802-0	2021	Ran participates in deltamethrin stress through regulating the nuclear import of Nrf2.	decamethrin	20-32	Keap1	Drosophila melanogaster	81-85
33069802-2	2021	In our previous study, it was suggested that Ran is involved in the deltamethrin (DM) stress.	decamethrin	68-80	Ran	Drosophila melanogaster	45-48
33069802-2	2021	In our previous study, it was suggested that Ran is involved in the deltamethrin (DM) stress.	decamethrin	82-84	Ran	Drosophila melanogaster	45-48
33069802-6	2021	In contrast, after overexpressing Ran in Kc cells, Nrf2 has a higher concentration in the nucleus, and the expressions of detoxification enzyme genes are up-regulated, while the DM-induced apoptosis is significantly lower than that of the control group.	decamethrin	178-180	Ran	Drosophila melanogaster	34-37
33069802-8	2021	In summary, our data mainly indicates that Ran may participate in DM stress through regulating the nuclear import of Nrf2, which could help to study the mechanism of deltamethrin resistance.	decamethrin	166-178	Ran	Drosophila melanogaster	43-46
33069802-8	2021	In summary, our data mainly indicates that Ran may participate in DM stress through regulating the nuclear import of Nrf2, which could help to study the mechanism of deltamethrin resistance.	decamethrin	166-178	Keap1	Drosophila melanogaster	117-121
32637473-0	2020	Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and beta4-peptide on human cardiac Nav1.5 sodium channel gating properties.	decamethrin	86-98	sodium voltage-gated channel alpha subunit 5	Homo sapiens	142-148
32651933-5	2021	Results have shown that compared with control group, 0.025 mg/L deltamethrin could significantly disturb the cardiac development, downregulating the expression of Scn5lab and transcriptional factors gata4 and nkx2.5, disturbing cardiac looping, resulting in defects in cardiac morphology and function.	decamethrin	64-76	sodium channel, voltage gated, type V-like, alpha b	Danio rerio	163-170
32651933-5	2021	Results have shown that compared with control group, 0.025 mg/L deltamethrin could significantly disturb the cardiac development, downregulating the expression of Scn5lab and transcriptional factors gata4 and nkx2.5, disturbing cardiac looping, resulting in defects in cardiac morphology and function.	decamethrin	64-76	GATA binding protein 4	Danio rerio	199-204
32651933-5	2021	Results have shown that compared with control group, 0.025 mg/L deltamethrin could significantly disturb the cardiac development, downregulating the expression of Scn5lab and transcriptional factors gata4 and nkx2.5, disturbing cardiac looping, resulting in defects in cardiac morphology and function.	decamethrin	64-76	NK2 homeobox 5	Danio rerio	209-215
32666189-7	2020	The scFv also showed 23.91%, 13.41%, 1.15%, 1.00%, and 0.56% cross-reactivity with phenothrin, deltamethrin, fenvalerate, beta-cypermethrin, and fenpropathrin.	decamethrin	95-107	immunglobulin heavy chain variable region	Homo sapiens	4-8
32976580-6	2020	Deltamethrin exposure significantly decreased bromodeoxyuridine (BrdU)-positive cells (39%) and Ki67+ cells (47%) in the dentate gyrus (DG) of the hippocampus, indicating decreased cellular proliferation.	decamethrin	0-12	antigen identified by monoclonal antibody Ki 67	Mus musculus	96-100
32976580-7	2020	In addition, deltamethrin-treated mice exhibited a 44% decrease in nestin-expressing neural progenitor cells and a 38% reduction in the expression of doublecortin (DCX), an early neuronal differentiation marker.	decamethrin	13-25	doublecortin	Mus musculus	150-162
32976580-7	2020	In addition, deltamethrin-treated mice exhibited a 44% decrease in nestin-expressing neural progenitor cells and a 38% reduction in the expression of doublecortin (DCX), an early neuronal differentiation marker.	decamethrin	13-25	doublecortin	Mus musculus	164-167
32387285-0	2020	Effects of Deltamethrin Acute Exposure on Nav1.6 channels and Medium Spiny Neurons of the Nucleus Accumbens.	decamethrin	11-23	neuron navigator 1	Homo sapiens	42-46
32387285-4	2020	Building on previous studies demonstrating that deltamethrin (DM), a commonly used pyrethroid, leads to use-dependent enhancement of sodium currents, we characterized the effect of the toxin on long-term inactivation (LTI) of the Nav1.6 channel, a parameter known to affect neuronal firing, and characterized changes in MSN intrinsic excitability.	decamethrin	48-60	sodium voltage-gated channel alpha subunit 8	Homo sapiens	230-236
31972291-6	2020	Additionally, DLM toxicity caused downregulation in antioxidant (CAT and GPx) and immune (IL-1beta and IL-8) related gene expressions, while and IFN-gamma, HSP70 and CASP3 were upregulated.	decamethrin	14-17	interleukin-1 beta	Oreochromis niloticus	90-98
32453986-3	2020	Genotypes expressing the yellow fever mosquito Aedes aegypti Cyp9J28 while also bearing the paraV1016G mutation displayed substantially greater resistance ratio (RR) against deltamethrin than the product of each individual mechanism (RRcombined: 19.85 > RRCyp9J28: 1.77 x RRV1016G: 3.00).	decamethrin	174-186	cytochrome P450 9e2	Aedes aegypti	61-68
32302602-4	2020	Here, we applied the classical type-II pyrethroid deltamethrin on human cardiac Nav1.5 and observed resurgent-like currents at very negative potentials in the absence of any pore-blocker, which resemble those hooked tail currents.	decamethrin	50-62	sodium voltage-gated channel alpha subunit 5	Homo sapiens	80-86
32302602-5	2020	We show that deltamethrin dramatically slows both fast inactivation and deactivation of Nav1.5 and thereby induces large persistent currents.	decamethrin	13-25	sodium voltage-gated channel alpha subunit 5	Homo sapiens	88-94
31765895-5	2020	In situ hybridization and qRT-PCR results showed that deltamethrin could interfere with the normal expression of cardiovascular development-related genes vegfr2, shh, gata4, nkx2.5, causing functional defects in the cardiovascular system.	decamethrin	54-66	kinase insert domain receptor like	Danio rerio	154-160
31765895-5	2020	In situ hybridization and qRT-PCR results showed that deltamethrin could interfere with the normal expression of cardiovascular development-related genes vegfr2, shh, gata4, nkx2.5, causing functional defects in the cardiovascular system.	decamethrin	54-66	sonic hedgehog signaling molecule a	Danio rerio	162-165
31765895-5	2020	In situ hybridization and qRT-PCR results showed that deltamethrin could interfere with the normal expression of cardiovascular development-related genes vegfr2, shh, gata4, nkx2.5, causing functional defects in the cardiovascular system.	decamethrin	54-66	GATA binding protein 4	Danio rerio	167-172
31765895-5	2020	In situ hybridization and qRT-PCR results showed that deltamethrin could interfere with the normal expression of cardiovascular development-related genes vegfr2, shh, gata4, nkx2.5, causing functional defects in the cardiovascular system.	decamethrin	54-66	NK2 homeobox 5	Danio rerio	174-180
31765895-6	2020	In addition, deltamethrin could affect the sleep-waking behavior of larvae, increasing the activity of larvae, decreasing the rest behavior and the expression of hcrt, hcrtr, aanat2 were down-regulated.	decamethrin	13-25	hypocretin (orexin) neuropeptide precursor	Danio rerio	162-166
31765895-6	2020	In addition, deltamethrin could affect the sleep-waking behavior of larvae, increasing the activity of larvae, decreasing the rest behavior and the expression of hcrt, hcrtr, aanat2 were down-regulated.	decamethrin	13-25	arylalkylamine N-acetyltransferase 2	Danio rerio	175-181
31376529-0	2020	Exploring the correlation between deltamethrin stress and Keap1-Nrf2-ARE pathway from Drosophila melanogaster RNASeq data.	decamethrin	34-46	Keap1	Drosophila melanogaster	58-63
31376529-0	2020	Exploring the correlation between deltamethrin stress and Keap1-Nrf2-ARE pathway from Drosophila melanogaster RNASeq data.	decamethrin	34-46	Keap1	Drosophila melanogaster	64-68
31838306-7	2020	Additionally, DLM toxicity downregulated the transcription of immune genes (IL-1beta and IL-8), while upregulated the stress related genes (HSP70 and CASP3).	decamethrin	14-17	interleukin-1 beta	Oreochromis niloticus	76-84
31838306-7	2020	Additionally, DLM toxicity downregulated the transcription of immune genes (IL-1beta and IL-8), while upregulated the stress related genes (HSP70 and CASP3).	decamethrin	14-17	interleukin-8	Oreochromis niloticus	89-93
31838306-7	2020	Additionally, DLM toxicity downregulated the transcription of immune genes (IL-1beta and IL-8), while upregulated the stress related genes (HSP70 and CASP3).	decamethrin	14-17	heat shock cognate 71 kDa protein	Oreochromis niloticus	140-145
31841155-4	2020	Here, we found that nerve growth factor (NGF) mRNA and protein was selectively reduced in the hippocampus of deltamethrin-treated mice.	decamethrin	109-121	nerve growth factor	Mus musculus	20-39
31841155-4	2020	Here, we found that nerve growth factor (NGF) mRNA and protein was selectively reduced in the hippocampus of deltamethrin-treated mice.	decamethrin	109-121	nerve growth factor	Mus musculus	41-44
31841155-6	2020	Exposure of neurons to deltamethrin (1-5 muM) caused ER stress as indicated by increased levels of C/EBP-homologous protein (CHOP) and glucose-regulated protein 78 (GRP-78).	decamethrin	23-35	DNA-damage inducible transcript 3	Mus musculus	99-123
31841155-6	2020	Exposure of neurons to deltamethrin (1-5 muM) caused ER stress as indicated by increased levels of C/EBP-homologous protein (CHOP) and glucose-regulated protein 78 (GRP-78).	decamethrin	23-35	DNA-damage inducible transcript 3	Mus musculus	125-129
31841155-6	2020	Exposure of neurons to deltamethrin (1-5 muM) caused ER stress as indicated by increased levels of C/EBP-homologous protein (CHOP) and glucose-regulated protein 78 (GRP-78).	decamethrin	23-35	heat shock protein 5	Mus musculus	135-163
31841155-6	2020	Exposure of neurons to deltamethrin (1-5 muM) caused ER stress as indicated by increased levels of C/EBP-homologous protein (CHOP) and glucose-regulated protein 78 (GRP-78).	decamethrin	23-35	heat shock protein 5	Mus musculus	165-171
31841155-8	2020	Inhibition of ER (endoplasmic reticulum) stress with the EIF2alpha (Eukaryotic Initiation Factor 2 alpha) inhibitor salubrinal abolished deltamethrin-induced activation of caspase-12 and caspase-3, and restored NGF levels.	decamethrin	137-149	eukaryotic translation initiation factor 2A	Mus musculus	57-66
31841155-8	2020	Inhibition of ER (endoplasmic reticulum) stress with the EIF2alpha (Eukaryotic Initiation Factor 2 alpha) inhibitor salubrinal abolished deltamethrin-induced activation of caspase-12 and caspase-3, and restored NGF levels.	decamethrin	137-149	caspase 12	Mus musculus	172-182
31841155-8	2020	Inhibition of ER (endoplasmic reticulum) stress with the EIF2alpha (Eukaryotic Initiation Factor 2 alpha) inhibitor salubrinal abolished deltamethrin-induced activation of caspase-12 and caspase-3, and restored NGF levels.	decamethrin	137-149	caspase 3	Mus musculus	187-196
31841155-8	2020	Inhibition of ER (endoplasmic reticulum) stress with the EIF2alpha (Eukaryotic Initiation Factor 2 alpha) inhibitor salubrinal abolished deltamethrin-induced activation of caspase-12 and caspase-3, and restored NGF levels.	decamethrin	137-149	nerve growth factor	Mus musculus	211-214
31841155-9	2020	Furthermore, deltamethrin decreased Akt (Protein kinase B) phosphorylation, which was significantly prevented by co-treatment with NGF or SC-79 in cells.	decamethrin	13-25	thymoma viral proto-oncogene 1	Mus musculus	36-39
31841155-9	2020	Furthermore, deltamethrin decreased Akt (Protein kinase B) phosphorylation, which was significantly prevented by co-treatment with NGF or SC-79 in cells.	decamethrin	13-25	nerve growth factor	Mus musculus	131-134
31841155-10	2020	Collectively, these results demonstrate that the loss of NGF following ER stress may contribute to deltamethrin-induced apoptosis in the hippocampus through the Akt signaling pathway, and that this may provide a plausible mechanism for impaired learning and memory observed following exposure of mice to deltamethrin.	decamethrin	99-111	nerve growth factor	Mus musculus	57-60
31841155-10	2020	Collectively, these results demonstrate that the loss of NGF following ER stress may contribute to deltamethrin-induced apoptosis in the hippocampus through the Akt signaling pathway, and that this may provide a plausible mechanism for impaired learning and memory observed following exposure of mice to deltamethrin.	decamethrin	99-111	thymoma viral proto-oncogene 1	Mus musculus	161-164
31841155-10	2020	Collectively, these results demonstrate that the loss of NGF following ER stress may contribute to deltamethrin-induced apoptosis in the hippocampus through the Akt signaling pathway, and that this may provide a plausible mechanism for impaired learning and memory observed following exposure of mice to deltamethrin.	decamethrin	304-316	nerve growth factor	Mus musculus	57-60
31683416-6	2020	After 6 mg kg-1 DM treatment, the thyroid stimulating hormone (TSH) content increased, and thyrotropin releasing hormone (TRH), triiodothyronine (T3) and thyroxine (T4) decreased.	decamethrin	16-18	thyrotropin releasing hormone	Mus musculus	91-120
31683416-9	2020	Western blot results showed that the expression level of tyrosine hydroxylase (TH) protein decreased and the content of dopamine transporter (DAT) protein increased in DM treated mice striatum.	decamethrin	168-170	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	120-140
31683416-9	2020	Western blot results showed that the expression level of tyrosine hydroxylase (TH) protein decreased and the content of dopamine transporter (DAT) protein increased in DM treated mice striatum.	decamethrin	168-170	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	142-145
31972291-6	2020	Additionally, DLM toxicity caused downregulation in antioxidant (CAT and GPx) and immune (IL-1beta and IL-8) related gene expressions, while and IFN-gamma, HSP70 and CASP3 were upregulated.	decamethrin	14-17	interleukin-8	Oreochromis niloticus	103-107
31972291-6	2020	Additionally, DLM toxicity caused downregulation in antioxidant (CAT and GPx) and immune (IL-1beta and IL-8) related gene expressions, while and IFN-gamma, HSP70 and CASP3 were upregulated.	decamethrin	14-17	heat shock cognate 71 kDa protein	Oreochromis niloticus	156-161
31476344-4	2019	Deltamethrin (10 muM) significantly increased fat accumulation, and the expression of adipogenic regulators, such as CCAAT/enhancer-binding protein (C/EBPalpha) and fatty acid synthase (FAS).	decamethrin	0-12	3-oxoacyl-[acyl-carrier-protein] reductase	Caenorhabditis elegans	165-184
32348866-0	2020	Combined neurodevelopmental exposure to deltamethrin and corticosterone is associated with Nr3c1 hypermethylation in the midbrain of male mice.	decamethrin	40-52	nuclear receptor subfamily 3, group C, member 1	Mus musculus	91-96
32348866-4	2020	Through targeted next-generation sequencing of a panel of cortisol and dopamine pathway genes, we observed hypermethylation of the glucocorticoid receptor gene, Nr3c1, in the midbrain of C57/BL6N males in response to dual deltamethrin and corticosterone exposures during development.	decamethrin	222-234	nuclear receptor subfamily 3, group C, member 1	Mus musculus	131-154
32348866-4	2020	Through targeted next-generation sequencing of a panel of cortisol and dopamine pathway genes, we observed hypermethylation of the glucocorticoid receptor gene, Nr3c1, in the midbrain of C57/BL6N males in response to dual deltamethrin and corticosterone exposures during development.	decamethrin	222-234	nuclear receptor subfamily 3, group C, member 1	Mus musculus	161-166
31476344-4	2019	Deltamethrin (10 muM) significantly increased fat accumulation, and the expression of adipogenic regulators, such as CCAAT/enhancer-binding protein (C/EBPalpha) and fatty acid synthase (FAS).	decamethrin	0-12	3-oxoacyl-[acyl-carrier-protein] reductase	Caenorhabditis elegans	186-189
31536935-0	2019	Effectiveness of the mass use of deltamethrin-impregnated dog collars for preventing transmission of canine leishmaniasis by Lutzomyia spp.	decamethrin	33-45	Signal peptide peptidase	Drosophila melanogaster	135-138
31536935-3	2019	The effectiveness of deltamethrin-impregnated dog collars for preventing transmission of canine leishmaniasis (CanL) by the sand fly Lutzomyia spp.	decamethrin	21-33	Signal peptide peptidase	Drosophila melanogaster	143-146
31536935-16	2019	This report evaluated the effectiveness of the mass use of deltamethrin-impregnated dog collars in areas of transmission of VL by Lutzomyia spp.	decamethrin	59-71	Signal peptide peptidase	Drosophila melanogaster	140-143
30247739-4	2019	Deltamethrin significantly increased the ER stress marker C/EBP-homologous protein (CHOP) in the hippocampus by 148% at 24 and 48 h compared with age-matched controls.	decamethrin	0-12	DNA-damage inducible transcript 3	Mus musculus	58-82
30695709-11	2019	KEY FINDINGS: DM treatment induced the ubiquitinated proteins expression with the peaks at 5 h. Moreover, DM increased DNA damage, early apoptotic rate, the expression level of Cleaved Caspase-3, caspase-3 activity and decreased the expression level of Bcl-2 at DM 24 h group.	decamethrin	14-16	caspase 3	Rattus norvegicus	196-205
30695709-11	2019	KEY FINDINGS: DM treatment induced the ubiquitinated proteins expression with the peaks at 5 h. Moreover, DM increased DNA damage, early apoptotic rate, the expression level of Cleaved Caspase-3, caspase-3 activity and decreased the expression level of Bcl-2 at DM 24 h group.	decamethrin	14-16	BCL2, apoptosis regulator	Rattus norvegicus	253-258
30695709-11	2019	KEY FINDINGS: DM treatment induced the ubiquitinated proteins expression with the peaks at 5 h. Moreover, DM increased DNA damage, early apoptotic rate, the expression level of Cleaved Caspase-3, caspase-3 activity and decreased the expression level of Bcl-2 at DM 24 h group.	decamethrin	106-108	caspase 3	Rattus norvegicus	196-205
30695709-11	2019	KEY FINDINGS: DM treatment induced the ubiquitinated proteins expression with the peaks at 5 h. Moreover, DM increased DNA damage, early apoptotic rate, the expression level of Cleaved Caspase-3, caspase-3 activity and decreased the expression level of Bcl-2 at DM 24 h group.	decamethrin	106-108	BCL2, apoptosis regulator	Rattus norvegicus	253-258
30709021-0	2019	Deltamethrin Residues in Milk and Cheese of Lactating Goats (Capra hircus).	decamethrin	0-12	Weaning weight-maternal milk	Bos taurus	25-29
30340169-6	2019	Deltamethrin resulted in induction of the cyp9q2 transcript at 0.53 ng/bee, while dimethoate led to induction of vitellogenin on the mRNA and protein level at 2 ng/bee.	decamethrin	0-12	cytochrome P450 9e2	Apis mellifera	42-48
31538121-2	2019	All eight pyrethroids tested in this study showed rat PXR agonistic activity; deltamethrin was the most potent, followed by cis-permethrin and cypermethrin.	decamethrin	78-90	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	54-57
31146137-3	2019	In this research, Drosophila kc cells treated with different doses of deltamethrin at different times, indicated that the expression of TCTP reached the highest level when the cells were treated with 20 ppm of deltamethrin at 24 h. The results showed that TCTP expression is associated with deltamethrin stress.	decamethrin	70-82	Translationally controlled tumor protein	Drosophila melanogaster	136-140
31146137-3	2019	In this research, Drosophila kc cells treated with different doses of deltamethrin at different times, indicated that the expression of TCTP reached the highest level when the cells were treated with 20 ppm of deltamethrin at 24 h. The results showed that TCTP expression is associated with deltamethrin stress.	decamethrin	70-82	Translationally controlled tumor protein	Drosophila melanogaster	256-260
31146137-3	2019	In this research, Drosophila kc cells treated with different doses of deltamethrin at different times, indicated that the expression of TCTP reached the highest level when the cells were treated with 20 ppm of deltamethrin at 24 h. The results showed that TCTP expression is associated with deltamethrin stress.	decamethrin	210-222	Translationally controlled tumor protein	Drosophila melanogaster	136-140
31146137-3	2019	In this research, Drosophila kc cells treated with different doses of deltamethrin at different times, indicated that the expression of TCTP reached the highest level when the cells were treated with 20 ppm of deltamethrin at 24 h. The results showed that TCTP expression is associated with deltamethrin stress.	decamethrin	210-222	Translationally controlled tumor protein	Drosophila melanogaster	256-260
31146137-3	2019	In this research, Drosophila kc cells treated with different doses of deltamethrin at different times, indicated that the expression of TCTP reached the highest level when the cells were treated with 20 ppm of deltamethrin at 24 h. The results showed that TCTP expression is associated with deltamethrin stress.	decamethrin	210-222	Translationally controlled tumor protein	Drosophila melanogaster	136-140
31146137-3	2019	In this research, Drosophila kc cells treated with different doses of deltamethrin at different times, indicated that the expression of TCTP reached the highest level when the cells were treated with 20 ppm of deltamethrin at 24 h. The results showed that TCTP expression is associated with deltamethrin stress.	decamethrin	210-222	Translationally controlled tumor protein	Drosophila melanogaster	256-260
31146137-5	2019	TCTP knockdown significantly reduced the level of resistance of RNAi-treated cells, and the overexpressions of TCTP in Drosophila kc cells conferred a degree of protection against deltamethrin.	decamethrin	180-192	Translationally controlled tumor protein	Drosophila melanogaster	111-115
31146137-7	2019	These results represent the first evidence that TCTP plays an important role in the regulation of deltamethrin resistance.	decamethrin	98-110	Translationally controlled tumor protein	Drosophila melanogaster	48-52
30850843-9	2019	Deltamethrin-treated rats exhibited increased CA1 hippocampal LTP, decreased extracellular dopamine release by microdialysis, reduced dopamine D1 receptor mRNA expression in neostriatum, and decreased norepinephrine levels in the hippocampus.	decamethrin	0-12	carbonic anhydrase 1	Rattus norvegicus	46-49
31052489-7	2019	Males exposed to deltamethrin had significantly decreased midbrain Pitx3 expression, decreased cortical tyrosine hydroxylase (TH) expression, increased activity in the Y maze, and increased dopamine uptake rate in the dorsal striatum.	decamethrin	17-29	paired like homeodomain 3	Homo sapiens	67-72
30802836-4	2019	Oxidative stress was found in mouse oocytes exposed to deltamethrin, as shown by changes in the expression of CAT and SOD2.	decamethrin	55-67	catalase	Mus musculus	110-113
30802836-4	2019	Oxidative stress was found in mouse oocytes exposed to deltamethrin, as shown by changes in the expression of CAT and SOD2.	decamethrin	55-67	superoxide dismutase 2, mitochondrial	Mus musculus	118-122
30802836-6	2019	The apoptosis of oocyte regulated by the expression of Bax and Bcl-2 protein was obviously affected by deltamethrin.	decamethrin	103-115	BCL2-associated X protein	Mus musculus	55-58
30802836-6	2019	The apoptosis of oocyte regulated by the expression of Bax and Bcl-2 protein was obviously affected by deltamethrin.	decamethrin	103-115	B cell leukemia/lymphoma 2	Mus musculus	63-68
29779438-0	2019	Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes.	decamethrin	14-26	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	76-112
29779438-1	2019	The metabolism of the pyrethroids deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes.	decamethrin	34-46	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	133-148
29779438-1	2019	The metabolism of the pyrethroids deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes.	decamethrin	34-46	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	150-153
30537588-8	2019	Deltamethrin significantly induced vascular endothelial growth factor flk1 and fli-1, cardiac development-related gene myl7 decreased in a dose-dependent manner.	decamethrin	0-12	Fli-1 proto-oncogene, ETS transcription factor	Danio rerio	79-123
30868487-8	2019	Additionally, perinatal deltamethrin exposure decreased the mRNA expression of Na+ channel regulatory subunit Navbeta1, inward rectifier K+ channel subunit Kir2.1, and delayed rectifier K+ channel subunit MERG while the L-type Ca2+ channel subunit, Cav1.2 expression was increased.	decamethrin	24-36	calcium channel, voltage-dependent, L type, alpha 1C subunit	Mus musculus	249-255
30518298-0	2019	Zebrafish embryos exposed to deltamethrin exhibit abnormalities despite induced expression of related genes ( you, you-too, momo and u-boot).	decamethrin	29-41	GLI family zinc finger 2a	Danio rerio	115-122
30518298-0	2019	Zebrafish embryos exposed to deltamethrin exhibit abnormalities despite induced expression of related genes ( you, you-too, momo and u-boot).	decamethrin	29-41	dharma	Danio rerio	124-128
30247739-4	2019	Deltamethrin significantly increased the ER stress marker C/EBP-homologous protein (CHOP) in the hippocampus by 148% at 24 and 48 h compared with age-matched controls.	decamethrin	0-12	DNA-damage inducible transcript 3	Mus musculus	84-88
30247739-5	2019	In contrast, CHOP was increased by 146% in the frontal cortex only at 48 h after deltamethrin exposure.	decamethrin	81-93	DNA-damage inducible transcript 3	Mus musculus	13-17
30247739-8	2019	Pre-treatment of mice with the eIf2alpha inhibitor salubrinal prevented deltamethrin-induced caspase-3 activation and attenuated the number of TUNEL-positive cells.	decamethrin	72-84	eukaryotic translation initiation factor 2A	Mus musculus	31-40
30247739-8	2019	Pre-treatment of mice with the eIf2alpha inhibitor salubrinal prevented deltamethrin-induced caspase-3 activation and attenuated the number of TUNEL-positive cells.	decamethrin	72-84	caspase 3	Mus musculus	93-102
30190420-4	2018	Most variation in parathion resistance was associated with mutations in the target gene Ace, while most variation in deltamethrin resistance was associated with mutations in Cyp6a23, a gene encoding a detoxification enzyme never previously associated with resistance.	decamethrin	117-129	Cyp6a23	Drosophila melanogaster	174-181
30190420-5	2018	A "nested GWAS" further revealed the contribution of other loci: Dscam1 and trpl were implicated in resistance to parathion, but only in lines lacking Wolbachia Cyp6a17, the paralogous gene of Cyp6a23, and CG7627, an ATP-binding cassette transporter, were implicated in deltamethrin resistance.	decamethrin	270-282	Down syndrome cell adhesion molecule 1	Drosophila melanogaster	65-71
30233298-0	2018	Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus.	decamethrin	9-21	brain-derived neurotrophic factor	Rattus norvegicus	115-119
30367663-10	2018	Deltamethrin exposure still significantly impaired survival of kdr homozygous mosquitoes, while mean daily temperature and relative humidity during the incubation period independently affected mosquito mortality.	decamethrin	0-12	kinase insert domain receptor	Homo sapiens	63-66
30344474-0	2018	Corrigendum: Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus.	decamethrin	22-34	brain derived neurotrophic factor	Homo sapiens	128-132
30233298-8	2018	The group treated with 9 mg/kg deltamethrin showed impaired cognitive abilities and decreased expression levels of GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB in the hippocampus.	decamethrin	31-43	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	115-120
30233298-8	2018	The group treated with 9 mg/kg deltamethrin showed impaired cognitive abilities and decreased expression levels of GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB in the hippocampus.	decamethrin	31-43	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	122-128
30233298-8	2018	The group treated with 9 mg/kg deltamethrin showed impaired cognitive abilities and decreased expression levels of GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB in the hippocampus.	decamethrin	31-43	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	130-136
30233298-8	2018	The group treated with 9 mg/kg deltamethrin showed impaired cognitive abilities and decreased expression levels of GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB in the hippocampus.	decamethrin	31-43	brain-derived neurotrophic factor	Rattus norvegicus	138-142
30233298-8	2018	The group treated with 9 mg/kg deltamethrin showed impaired cognitive abilities and decreased expression levels of GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB in the hippocampus.	decamethrin	31-43	cAMP responsive element binding protein 1	Rattus norvegicus	145-149
30233298-8	2018	The group treated with 9 mg/kg deltamethrin showed impaired cognitive abilities and decreased expression levels of GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB in the hippocampus.	decamethrin	31-43	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	161-165
30233298-11	2018	Moreover, NMDAR/BDNF signaling may be associated with the effects of prenatal exposure to deltamethrin on cognitive ability in offspring.	decamethrin	90-102	brain-derived neurotrophic factor	Rattus norvegicus	16-20
28119079-8	2017	Deltamethrin increased fat accumulation via aak-2 (an ortholog of AMPKalpha) and nhr-49 (a homolog of peroxisome proliferator-activated receptor-alpha and also downstream target of aak-2) mediated mechanisms.	decamethrin	0-12	5'-AMP-activated protein kinase catalytic subunit alpha-2	Caenorhabditis elegans	44-49
31106288-11	2018	Associations with cis-3-(2,2-dibromovinyl)-2,2-dimethyl-cyclopropane carboxylic acid, a metabolite specific to deltamethrin, were weaker or absent.	decamethrin	111-123	suppressor of cytokine signaling 3	Homo sapiens	18-23
29380240-5	2018	Short- and long-term treatments with tacrolimus, cyclosporin A or another CNI deltamethrin (herbicide) decreased basal and insulin-dependent glucose uptake in adipocytes, without any additive effects observed when added together.	decamethrin	78-90	insulin	Homo sapiens	123-130
29680247-3	2018	In our previous studies, we reported that Ran is the deltamethrin (DM) resistance-associated gene.	decamethrin	53-65	Ran	Drosophila melanogaster	42-45
29626809-0	2018	Cypermethrin, chlorpyrifos, deltamethrin, and imidacloprid exposure up-regulates the mRNA and protein levels of bdnf and c-fos in the brain of adult zebrafish (Danio rerio).	decamethrin	28-40	brain-derived neurotrophic factor	Danio rerio	112-116
29626809-0	2018	Cypermethrin, chlorpyrifos, deltamethrin, and imidacloprid exposure up-regulates the mRNA and protein levels of bdnf and c-fos in the brain of adult zebrafish (Danio rerio).	decamethrin	28-40	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	121-126
29626809-1	2018	The aim of the present study is to investigate the toxicity effects of frequently used pesticides, involving cypermethrin, deltamethrin, chlorpyrifos and imidacloprid, on the expression of bdnf and c-fos genes in zebrafish brain tissues.	decamethrin	123-135	brain-derived neurotrophic factor	Danio rerio	189-193
29626809-1	2018	The aim of the present study is to investigate the toxicity effects of frequently used pesticides, involving cypermethrin, deltamethrin, chlorpyrifos and imidacloprid, on the expression of bdnf and c-fos genes in zebrafish brain tissues.	decamethrin	123-135	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	198-203
29626809-6	2018	These results showed that the exposure to the acute cypermethrin, deltamethrin, chlorpyrifos and imidacloprid intoxication disrupted the normal neuronal activity, resulting in neurotoxic effect, also DNA-binding Increasing c-fos activation, an oncoprotein from the family of the Nuclear Proteins, is also true of the knowledge that these chemicals are oncogenic in zebrafish brain tissues.	decamethrin	66-78	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	223-228
29564709-0	2018	Oral exposure of deltamethrin and/or lipopolysaccharide (LPS) induced activation of the pulmonary immune system in Swiss albino mice.	decamethrin	17-29	toll-like receptor 4	Mus musculus	57-60
29564709-10	2018	Deltamethrin exposure alone and/or with endotoxin revealed different degrees of immunopositive reaction for Toll-like receptor 4 (TLR4) and pro-inflammatory cytokine-like tumor necrosis factor-alpha (TNFalpha) in different parts of the lungs.	decamethrin	0-12	toll-like receptor 4	Mus musculus	108-128
29564709-10	2018	Deltamethrin exposure alone and/or with endotoxin revealed different degrees of immunopositive reaction for Toll-like receptor 4 (TLR4) and pro-inflammatory cytokine-like tumor necrosis factor-alpha (TNFalpha) in different parts of the lungs.	decamethrin	0-12	toll-like receptor 4	Mus musculus	130-134
29564709-10	2018	Deltamethrin exposure alone and/or with endotoxin revealed different degrees of immunopositive reaction for Toll-like receptor 4 (TLR4) and pro-inflammatory cytokine-like tumor necrosis factor-alpha (TNFalpha) in different parts of the lungs.	decamethrin	0-12	tumor necrosis factor	Mus musculus	200-208
29564709-12	2018	Thus, chronic low-level deltamethrin exposure may impair the main pro-inflammatory response in the lungs which is more pronounced in combination with LPS.	decamethrin	24-36	toll-like receptor 4	Mus musculus	150-153
29594621-7	2018	The detection limits for bifenthrin, fenpropathrin, lambda-cyhalothrin, permethrin, and deltamethrin range from 5 to 9 pg mL-1.	decamethrin	88-100	L1 cell adhesion molecule	Mus musculus	122-126
28810533-7	2017	Deltamethrin intoxicated rats revealed a significant increase in serum kidney and brain indicators as well as creatinin, urea and uric acid levels, and AChE activity as compared to control rats.	decamethrin	0-12	acetylcholinesterase	Rattus norvegicus	152-156
28810533-8	2017	In addition, kidney and brain lipid peroxidation and antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were altered significantly in deltamethrin treated rats.	decamethrin	187-199	catalase	Rattus norvegicus	109-117
28810533-8	2017	In addition, kidney and brain lipid peroxidation and antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were altered significantly in deltamethrin treated rats.	decamethrin	187-199	catalase	Rattus norvegicus	119-122
28792275-4	2017	Deltamethrin exposure elicited a transient reduction in the levels of superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase and a persistent decrease in glutathione reductase activity.	decamethrin	0-12	glutathione peroxidase 1	Oncorhynchus mykiss	102-124
27058123-10	2017	Deltamethrin exposure also resulted in the persistent down-regulation of brain-derived neurotrophic factor (Bdnf) in the striatum by 66% but not in the cortex, suggesting a plausible mechanism for some of the associated behavioral effects observed previously.	decamethrin	0-12	brain derived neurotrophic factor	Mus musculus	73-106
27058123-10	2017	Deltamethrin exposure also resulted in the persistent down-regulation of brain-derived neurotrophic factor (Bdnf) in the striatum by 66% but not in the cortex, suggesting a plausible mechanism for some of the associated behavioral effects observed previously.	decamethrin	0-12	brain derived neurotrophic factor	Mus musculus	108-112
27058123-11	2017	Taken together these data suggest that developmental deltamethrin exposure results in persistent deficits in Nav and BDNF mRNA expression that may contribute to long-term behavioral deficits.	decamethrin	53-65	brain derived neurotrophic factor	Mus musculus	117-121
28456310-6	2017	To identify the potential target of deltamethrin, we exposed C. elegans to different concentrations of deltamethrin and Ca2+ channel blockers for different times, characterized the behavioral toxicity of deltamethrin on C. elegans, and determined the expression of egl-19, unc-2, and cca-1, which encode the alpha1-subunit of the L-, R/N/P/Q-, and T-type VGCC, respectively.	decamethrin	36-48	Voltage-dependent L-type calcium channel subunit alpha	Caenorhabditis elegans	265-271
28456310-6	2017	To identify the potential target of deltamethrin, we exposed C. elegans to different concentrations of deltamethrin and Ca2+ channel blockers for different times, characterized the behavioral toxicity of deltamethrin on C. elegans, and determined the expression of egl-19, unc-2, and cca-1, which encode the alpha1-subunit of the L-, R/N/P/Q-, and T-type VGCC, respectively.	decamethrin	36-48	EF-hand domain-containing protein	Caenorhabditis elegans	273-278
28456310-6	2017	To identify the potential target of deltamethrin, we exposed C. elegans to different concentrations of deltamethrin and Ca2+ channel blockers for different times, characterized the behavioral toxicity of deltamethrin on C. elegans, and determined the expression of egl-19, unc-2, and cca-1, which encode the alpha1-subunit of the L-, R/N/P/Q-, and T-type VGCC, respectively.	decamethrin	36-48	Voltage-dependent T-type calcium channel subunit alpha	Caenorhabditis elegans	284-289
28456310-8	2017	We also showed that body length of worms on agar plates containing 200mgL-1 deltamethrin for 12h was not significantly different from controls, whereas the cholinesterase inhibitor carbofuran caused hypercontraction which is a characteristic of organophosphates and carbamates, suggesting that deltamethrin"s mode of action is distinct from those nematicides.	decamethrin	76-88	G_PROTEIN_RECEP_F3_4 domain-containing protein;putative metabotropic glutamate receptor mgl-1	Caenorhabditis elegans	70-75
28456310-9	2017	In addition, unc-2 was significantly up-regulated following 0.05mgL-1 deltamethrin exposure for 24h; while egl-19 and cca-1 were significantly up-regulated following 5 and 50mgL-1 deltamethrin exposure for 24h.	decamethrin	70-82	EF-hand domain-containing protein	Caenorhabditis elegans	13-18
28456310-9	2017	In addition, unc-2 was significantly up-regulated following 0.05mgL-1 deltamethrin exposure for 24h; while egl-19 and cca-1 were significantly up-regulated following 5 and 50mgL-1 deltamethrin exposure for 24h.	decamethrin	180-192	Voltage-dependent L-type calcium channel subunit alpha	Caenorhabditis elegans	107-113
28456310-9	2017	In addition, unc-2 was significantly up-regulated following 0.05mgL-1 deltamethrin exposure for 24h; while egl-19 and cca-1 were significantly up-regulated following 5 and 50mgL-1 deltamethrin exposure for 24h.	decamethrin	180-192	Voltage-dependent T-type calcium channel subunit alpha	Caenorhabditis elegans	118-123
28242322-4	2017	The results demonstrated that most of the tested pyrethroids showed moderate to weak inhibitory effects against both CES1 and CES2, but deltamethrin displayed strong inhibition towards CES1.	decamethrin	136-148	carboxylesterase 1	Homo sapiens	185-189
28242322-5	2017	The IC50 values of deltamethrin against CES1-mediated BMBT, DME, and DMCB hydrolysis were determined as 1.58muM, 2.39muM, and 3.3muM, respectively.	decamethrin	19-31	carboxylesterase 1	Homo sapiens	40-44
28242322-6	2017	Moreover, deltamethrin was cell membrane permeable and capable of inhibition endogenous CES1 in living cells.	decamethrin	10-22	carboxylesterase 1	Homo sapiens	88-92
28242322-7	2017	Further investigation revealed that deltamethrin inhibited CES1-mediated BMBT hydrolysis via competitive manner but noncompetitively inhibited DME or DMCB hydrolysis.	decamethrin	36-48	carboxylesterase 1	Homo sapiens	59-63
28242322-8	2017	The inhibition behaviors of deltamethrin against CES1 were also studied by molecular docking simulation.	decamethrin	28-40	carboxylesterase 1	Homo sapiens	49-53
28242322-9	2017	The results demonstrated that CES1 had at least two different ligand-binding sites, one was the DME site and another was the BMBT site which was identical to the binding site of deltamethrin.	decamethrin	178-190	carboxylesterase 1	Homo sapiens	30-34
28242322-10	2017	In summary, deltamethrin was a strong reversible inhibitor against CES1 and it could tightly bind on CES1 at the same ligand-binding site as BMBT.	decamethrin	12-24	carboxylesterase 1	Homo sapiens	67-71
28242322-10	2017	In summary, deltamethrin was a strong reversible inhibitor against CES1 and it could tightly bind on CES1 at the same ligand-binding site as BMBT.	decamethrin	12-24	carboxylesterase 1	Homo sapiens	101-105
28503953-0	2018	Effect of deltamethrin and fluoride co-exposure on the brain antioxidant status and cholinesterase activity in Wistar rats.	decamethrin	10-22	butyrylcholinesterase	Rattus norvegicus	84-98
28503953-1	2018	The study evaluated the effect of commercial preparation of deltamethrin, Butox , and fluoride (F-) co-exposure on the brain antioxidant status and cholinesterase activity in rats.	decamethrin	60-72	butyrylcholinesterase	Rattus norvegicus	148-162
28503953-8	2018	The activity of erythrocyte acetylcholinesterase (AChE) was inhibited in Butox  treated groups, whereas brain AChE activity was inhibited in all treatment groups.	decamethrin	73-78	acetylcholinesterase	Rattus norvegicus	50-54
28503953-9	2018	In conclusion, both deltamethrin (given as Butox ) and F- inhibit AChE activity and produce oxidative stress in brain with F- producing more oxidative damage.	decamethrin	20-32	acetylcholinesterase	Rattus norvegicus	66-70
28503953-9	2018	In conclusion, both deltamethrin (given as Butox ) and F- inhibit AChE activity and produce oxidative stress in brain with F- producing more oxidative damage.	decamethrin	43-48	acetylcholinesterase	Rattus norvegicus	66-70
28943602-0	2017	Deltamethrin Increases Neurite Outgrowth in Cortical Neurons through Endogenous BDNF/TrkB Pathways.	decamethrin	0-12	brain-derived neurotrophic factor	Rattus norvegicus	80-84
28943602-0	2017	Deltamethrin Increases Neurite Outgrowth in Cortical Neurons through Endogenous BDNF/TrkB Pathways.	decamethrin	0-12	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	85-89
28943602-1	2017	Deltamethrin (DM), a type II pyrethroid, robustly increases brain-derived neurotrophic factor (Bdnf) expression and has a neurotrophic effect in primary cultures of rat cortical neurons.	decamethrin	0-12	brain-derived neurotrophic factor	Rattus norvegicus	60-93
28943602-1	2017	Deltamethrin (DM), a type II pyrethroid, robustly increases brain-derived neurotrophic factor (Bdnf) expression and has a neurotrophic effect in primary cultures of rat cortical neurons.	decamethrin	0-12	brain-derived neurotrophic factor	Rattus norvegicus	95-99
28943602-1	2017	Deltamethrin (DM), a type II pyrethroid, robustly increases brain-derived neurotrophic factor (Bdnf) expression and has a neurotrophic effect in primary cultures of rat cortical neurons.	decamethrin	14-16	brain-derived neurotrophic factor	Rattus norvegicus	60-93
28943602-1	2017	Deltamethrin (DM), a type II pyrethroid, robustly increases brain-derived neurotrophic factor (Bdnf) expression and has a neurotrophic effect in primary cultures of rat cortical neurons.	decamethrin	14-16	brain-derived neurotrophic factor	Rattus norvegicus	95-99
28943602-10	2017	Taken together, these findings suggest that DM activates endogenous BDNF/TrkB-mediated MAPK and mTOR pathways, thereby increasing neurite outgrowth.Key words: BDNF, Deltamethrin, MAPK, mTOR, Neurite outgrowth.	decamethrin	165-177	brain-derived neurotrophic factor	Rattus norvegicus	68-72
28943602-10	2017	Taken together, these findings suggest that DM activates endogenous BDNF/TrkB-mediated MAPK and mTOR pathways, thereby increasing neurite outgrowth.Key words: BDNF, Deltamethrin, MAPK, mTOR, Neurite outgrowth.	decamethrin	165-177	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	73-77
28551743-2	2017	The assay of brain parameters showed that Deltamethrin caused a significant increase of mitochondrial metabolite level (proteins, lipids, and carbohydrates) and enzyme activity (glutathione S-transferase and superoxide dismutase); a decreased amount of mitochondrial glutathione level and catalase and glutathione peroxidase activities; and an increase of malondialdehyde (MDA) acid levels of the two regions.	decamethrin	42-54	hematopoietic prostaglandin D synthase	Rattus norvegicus	178-203
28007400-0	2017	Consequences of acute Nav1.1 exposure to deltamethrin.	decamethrin	41-53	sodium voltage-gated channel alpha subunit 1	Homo sapiens	22-28
28007400-2	2017	OBJECTIVE: Here we compare the well-studied Nav1.6 isoforms to the less-understood Nav1.1 in their responses to acute deltamethrin exposure.	decamethrin	118-130	neuron navigator 1	Homo sapiens	44-48
28007400-2	2017	OBJECTIVE: Here we compare the well-studied Nav1.6 isoforms to the less-understood Nav1.1 in their responses to acute deltamethrin exposure.	decamethrin	118-130	sodium voltage-gated channel alpha subunit 1	Homo sapiens	83-89
28007400-5	2017	RESULTS: We found that exposure of both isoforms to 10muM deltamethrin significantly potentiated persistent and tail current densities without affecting peak transient current densities, and only Nav1.1 maintained these significant effects at 1muM deltamethrin.	decamethrin	248-260	sodium voltage-gated channel alpha subunit 1	Homo sapiens	196-202
28007400-6	2017	Window currents increased for both as well, and while only Nav1.6 displayed changes in activation slope and V1/2 of steady-state inactivation for peak currents, V1/2 of persistent current activation was hyperpolarized of ~10mV by deltamethrin in Nav1.1 cells.	decamethrin	230-242	sodium voltage-gated channel alpha subunit 8	Homo sapiens	59-65
28007400-6	2017	Window currents increased for both as well, and while only Nav1.6 displayed changes in activation slope and V1/2 of steady-state inactivation for peak currents, V1/2 of persistent current activation was hyperpolarized of ~10mV by deltamethrin in Nav1.1 cells.	decamethrin	230-242	neuron navigator 1	Homo sapiens	59-63
28007400-7	2017	Evaluating use-dependence, we found that deltamethrin again potentiated persistent and tail current densities in both isoforms, but only Nav1.6 demonstrated use-dependent enhancement, indicating the primary deltamethrin-induced effects on Nav1.1 channels are not use-dependent.	decamethrin	207-219	sodium voltage-gated channel alpha subunit 1	Homo sapiens	239-245
28007400-8	2017	CONCLUSION: Collectively, these data provide evidence that Nav1.1 is indeed vulnerable to deltamethrin modification at lower concentrations than Nav1.6, and this effect is primarily mediated during the resting state.	decamethrin	90-102	sodium voltage-gated channel alpha subunit 1	Homo sapiens	59-65
28119079-8	2017	Deltamethrin increased fat accumulation via aak-2 (an ortholog of AMPKalpha) and nhr-49 (a homolog of peroxisome proliferator-activated receptor-alpha and also downstream target of aak-2) mediated mechanisms.	decamethrin	0-12	NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49	Caenorhabditis elegans	81-87
28119079-8	2017	Deltamethrin increased fat accumulation via aak-2 (an ortholog of AMPKalpha) and nhr-49 (a homolog of peroxisome proliferator-activated receptor-alpha and also downstream target of aak-2) mediated mechanisms.	decamethrin	0-12	5'-AMP-activated protein kinase catalytic subunit alpha-2	Caenorhabditis elegans	181-186
28119079-9	2017	The current work is the first report of the effects of deltamethrin on increased fat storage by 3T3- L1 adipocytes and C. elegans via aak-2 (AMPKalpha ortholog)-mediated mechanism.	decamethrin	55-67	5'-AMP-activated protein kinase catalytic subunit alpha-2	Caenorhabditis elegans	134-139
27825714-3	2017	The average AChE activity decreased comparing to 0.0 TU with DM (82.81% in 0.1 TU, 56.14% in 1.0 TU and 44.68% in 2.0 TU) and with CdCl2 (74.68% in 0.1 TU, 52.05% in 1.0 TU and 50.14% in 2.0 TU) showed an overall decrease with the increase of exposure concentrations.	decamethrin	61-63	acetylcholinesterase	Danio rerio	12-16
27188467-0	2016	Ca2+ Movement Induced by Deltamethrin in PC3 Human Prostate Cancer Cells.	decamethrin	25-37	chromobox 8	Homo sapiens	41-44
26588882-0	2017	mTOR inhibition by rapamycin protects against deltamethrin-induced apoptosis in PC12 Cells.	decamethrin	46-58	mechanistic target of rapamycin kinase	Rattus norvegicus	0-4
27655349-3	2017	Based on this finding and the fact that pyrethroid pesticides act on VGSC, we hypothesized that exposure of microglia to the pyrethroid pesticides, permethrin and deltamethrin, would activate microglia and increase the release of TNF-alpha.	decamethrin	163-175	tumor necrosis factor	Mus musculus	230-239
27655349-5	2017	Furthermore, deltamethrin and permethrin increased the release of TNF-alpha in a dose- and time-dependent manner, which was significantly reduced by pre-treatment of cells with TTX.	decamethrin	13-25	tumor necrosis factor	Mus musculus	66-75
27622324-0	2016	Deltamethrin induced RIPK3-mediated caspase-independent non-apoptotic cell death in rat primary hepatocytes.	decamethrin	0-12	receptor-interacting serine-threonine kinase 3	Rattus norvegicus	21-26
27553674-0	2016	PPAR-gamma activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction.	decamethrin	33-45	peroxisome proliferator activated receptor gamma	Homo sapiens	0-10
27553674-0	2016	PPAR-gamma activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction.	decamethrin	33-45	PTEN induced kinase 1	Homo sapiens	88-93
27188467-1	2016	This study explored the effect of deltamethrin, a pesticide, on intracellular free Ca2+ concentration ([Ca2+]i) in PC3 human prostate cancer cells.	decamethrin	34-46	chromobox 8	Homo sapiens	115-118
27188467-2	2016	Deltamethrin at concentrations between 5 muM and 20 muM evoked [Ca2+]i rises in a concentration-dependent manner.	decamethrin	0-12	latexin	Homo sapiens	41-44
27188467-2	2016	Deltamethrin at concentrations between 5 muM and 20 muM evoked [Ca2+]i rises in a concentration-dependent manner.	decamethrin	0-12	latexin	Homo sapiens	52-55
27188467-8	2016	Deltamethrin killed cells at concentrations of 20-100 muM in a concentration-dependent fashion.	decamethrin	0-12	latexin	Homo sapiens	54-57
27188467-10	2016	Together, in PC3 human prostate cancer cells, deltamethrin induced [Ca2+]i rises that involved Ca2+ entry through store-operated Ca2+ channels and PLC-independent Ca2+ release from the endoplasmic reticulum.	decamethrin	46-58	chromobox 8	Homo sapiens	13-16
26891306-5	2016	In HEK-293 cells heterologously expressing hNav1.7 alpha-subunit, ATX produced a robust membrane depolarization with an EC50 value of 7.8 +- 2.9 nM whereas veratridine, BmK NT1, and deltamethrin produced marginal response.	decamethrin	182-194	sodium voltage-gated channel alpha subunit 9	Homo sapiens	43-50
26924245-0	2016	Up-regulated expression of Ran reveals its potential role to deltamethrin stress in Kc cells.	decamethrin	61-73	RAN, member RAS oncogene family	Homo sapiens	27-30
26764169-0	2016	IDENTIFICATION OF PROTEASOME ALPHA6 SUBUNIT ASSOCIATED WITH DELTAMETHRIN RESISTANCE IN Drosophila melanogaster Kc CELLS.	decamethrin	60-72	Proteasome alpha6 subunit	Drosophila melanogaster	18-43
26764169-1	2016	Differential expression of the proteasome alpha6 (prosalpha6) was previously reported between Plutella xylostella strains that are resistant or susceptible to the pesticide deltamethrin (DM).	decamethrin	173-185	Proteasome alpha6 subunit	Drosophila melanogaster	50-60
25983007-0	2015	PROTEOMIC ANALYSIS OF UBIQUITINATED PROTEINS FROM DELTAMETHRIN-RESISTANT AND SUSCEPTIBLE STRAINS OF THE DIAMONDBACK MOTH, Plutella Xylostella L. Ubiquitin, a small protein consisting of 76 amino acids, acts in protein degradation, DNA repair, signal transduction, transcriptional regulation, and receptor control through endocytosis.	decamethrin	50-62	LOW QUALITY PROTEIN: ubiquitin-60S ribosomal protein L40	Plutella xylostella	145-154
26708501-0	2016	Effects of the beta1 auxiliary subunit on modification of Rat Na(v)1.6 sodium channels expressed in HEK293 cells by the pyrethroid insecticides tefluthrin and deltamethrin.	decamethrin	159-171	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	15-20
26708501-6	2016	Coexpression of Nav1.6 with the beta1 subunit had no effect on the kinetic behavior of pyrethroid-modified channels but had divergent effects on the voltage-dependent gating of tefluthrin- or deltamethrin-modified channels, increasing the size of tefluthrin-induced window currents but decreasing the size of corresponding deltamethrin-induced currents.	decamethrin	192-204	neuron navigator 1	Homo sapiens	16-20
26708501-6	2016	Coexpression of Nav1.6 with the beta1 subunit had no effect on the kinetic behavior of pyrethroid-modified channels but had divergent effects on the voltage-dependent gating of tefluthrin- or deltamethrin-modified channels, increasing the size of tefluthrin-induced window currents but decreasing the size of corresponding deltamethrin-induced currents.	decamethrin	192-204	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	32-37
26708501-6	2016	Coexpression of Nav1.6 with the beta1 subunit had no effect on the kinetic behavior of pyrethroid-modified channels but had divergent effects on the voltage-dependent gating of tefluthrin- or deltamethrin-modified channels, increasing the size of tefluthrin-induced window currents but decreasing the size of corresponding deltamethrin-induced currents.	decamethrin	323-335	neuron navigator 1	Homo sapiens	16-20
26708501-6	2016	Coexpression of Nav1.6 with the beta1 subunit had no effect on the kinetic behavior of pyrethroid-modified channels but had divergent effects on the voltage-dependent gating of tefluthrin- or deltamethrin-modified channels, increasing the size of tefluthrin-induced window currents but decreasing the size of corresponding deltamethrin-induced currents.	decamethrin	323-335	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	32-37
27999812-0	2016	Integrative Characterization of Toxic Response of Zebra Fish (Danio rerio) to Deltamethrin Based on AChE Activity and Behavior Strength.	decamethrin	78-90	acetylcholinesterase	Danio rerio	100-104
25630971-6	2015	Mice exposed to the pyrethroid pesticide deltamethrin during development exhibit several features reminiscent of ADHD, including elevated dopamine transporter (DAT) levels, hyperactivity, working memory and attention deficits, and impulsive-like behavior.	decamethrin	41-53	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	138-158
25912032-5	2015	Deltamethrin exposure resulted in decreased transcript levels of the D1 dopamine (DA) receptor (drd1) and increased levels of tyrosine hydroxylase at 72 hpf.	decamethrin	0-12	dopamine receptor D1a	Danio rerio	96-100
25630971-6	2015	Mice exposed to the pyrethroid pesticide deltamethrin during development exhibit several features reminiscent of ADHD, including elevated dopamine transporter (DAT) levels, hyperactivity, working memory and attention deficits, and impulsive-like behavior.	decamethrin	41-53	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	160-163
25358543-4	2015	Here, we report that the type-II pyrethroid deltamethrin, which has a similar mechanism as these toxins, elicited an approximate 25% reduction in Na(v) 1.2 and Na(v) 1.3 mRNA in SK-N-AS cells.	decamethrin	44-56	immunoglobulin lambda variable 2-8	Homo sapiens	146-155
25358543-4	2015	Here, we report that the type-II pyrethroid deltamethrin, which has a similar mechanism as these toxins, elicited an approximate 25% reduction in Na(v) 1.2 and Na(v) 1.3 mRNA in SK-N-AS cells.	decamethrin	44-56	immunoglobulin lambda variable 2-11	Homo sapiens	160-169
25687544-5	2015	We confirmed that the I265N mutation reduced the sensitivity to two pyrethroids, permethrin and deltamethrin of a DmNav variant expressed in Xenopus oocytes.	decamethrin	96-108	paralytic	Drosophila melanogaster	114-119
24674905-5	2014	The result showed that deltamethrin, alone or in combination with azamethiphos, affected the transcriptional levels of several oxidative stress markers, including MnSOD (SOD2) and HSP70 (HSPA8) in the liver, and GPX1, CAT, MnSOD, HSP70 and GSTP1 in the gills.	decamethrin	23-35	superoxide dismutase 2, mitochondrial	Salmo salar	170-174
25299849-0	2014	eNOS-JNK1-AR signaling pathway mediates deltamethrin-induced germ cells apoptosis in testes of adult rats.	decamethrin	40-52	androgen receptor	Rattus norvegicus	10-12
25029214-2	2014	TFG oil was evaluated for its protective effect against deltamethrin toxicity in rats.	decamethrin	56-68	trafficking from ER to golgi regulator	Rattus norvegicus	0-3
24875908-3	2014	The binding abilities of pesticides to CAT followed the order: fenvalerate>deltamethrin>disulfoton>isofenphos-methyl>carbaryl>malathion>isocarbophos>dimethoate>dipterex>acephate>methomyl>methamidophos, which was generally similar to the order of determination sensitivity of pesticides.	decamethrin	78-90	catalase	Homo sapiens	39-42
25796143-1	2015	The continuous effects on Acetylcholinesterase (AChE) activity of medaka (Oryzias latipes) caused by dichlorvos, methomyl and deltamethrin in vivo were investigated, and the trends of AChE activity inhibition due to the influence of these insecticides were discussed.	decamethrin	126-138	acetylcholinesterase	Oryzias latipes	26-46
25796143-1	2015	The continuous effects on Acetylcholinesterase (AChE) activity of medaka (Oryzias latipes) caused by dichlorvos, methomyl and deltamethrin in vivo were investigated, and the trends of AChE activity inhibition due to the influence of these insecticides were discussed.	decamethrin	126-138	acetylcholinesterase	Oryzias latipes	48-52
25403829-2	2014	DL is a deltamethrin-treated polyethylene material, which when used to cover interior house walls, functions as long-lasting IRS.	decamethrin	8-20	isoleucyl-tRNA synthetase 1	Homo sapiens	125-128
24674905-5	2014	The result showed that deltamethrin, alone or in combination with azamethiphos, affected the transcriptional levels of several oxidative stress markers, including MnSOD (SOD2) and HSP70 (HSPA8) in the liver, and GPX1, CAT, MnSOD, HSP70 and GSTP1 in the gills.	decamethrin	23-35	heat shock protein 70	Salmo salar	180-185
24674905-5	2014	The result showed that deltamethrin, alone or in combination with azamethiphos, affected the transcriptional levels of several oxidative stress markers, including MnSOD (SOD2) and HSP70 (HSPA8) in the liver, and GPX1, CAT, MnSOD, HSP70 and GSTP1 in the gills.	decamethrin	23-35	heat shock cognate 71 kDa protein	Salmo salar	187-192
24674905-5	2014	The result showed that deltamethrin, alone or in combination with azamethiphos, affected the transcriptional levels of several oxidative stress markers, including MnSOD (SOD2) and HSP70 (HSPA8) in the liver, and GPX1, CAT, MnSOD, HSP70 and GSTP1 in the gills.	decamethrin	23-35	heat shock protein 70	Salmo salar	230-235
24674905-5	2014	The result showed that deltamethrin, alone or in combination with azamethiphos, affected the transcriptional levels of several oxidative stress markers, including MnSOD (SOD2) and HSP70 (HSPA8) in the liver, and GPX1, CAT, MnSOD, HSP70 and GSTP1 in the gills.	decamethrin	23-35	glutathione S-transferase P	Salmo salar	240-245
24728095-6	2014	In this study, we aim to further investigate the involvement of RPS29 in deltamethrin resistance.	decamethrin	73-85	ribosomal protein S29	Homo sapiens	64-69
24728095-13	2014	CONCLUSIONS AND SIGNIFICANCE: These observations indicate that CYP6N3, a novel RPS29-interacting partner, could stimulate deltamethrin resistance in mosquito cells and RPS29 overexpression targeted CYP6N3 for proteosomal degradation, abrogating the CYP6N3-associated resistence to deltamethrin.	decamethrin	122-134	ribosomal protein S29	Homo sapiens	79-84
24728095-13	2014	CONCLUSIONS AND SIGNIFICANCE: These observations indicate that CYP6N3, a novel RPS29-interacting partner, could stimulate deltamethrin resistance in mosquito cells and RPS29 overexpression targeted CYP6N3 for proteosomal degradation, abrogating the CYP6N3-associated resistence to deltamethrin.	decamethrin	281-293	ribosomal protein S29	Homo sapiens	79-84
24728095-13	2014	CONCLUSIONS AND SIGNIFICANCE: These observations indicate that CYP6N3, a novel RPS29-interacting partner, could stimulate deltamethrin resistance in mosquito cells and RPS29 overexpression targeted CYP6N3 for proteosomal degradation, abrogating the CYP6N3-associated resistence to deltamethrin.	decamethrin	281-293	ribosomal protein S29	Homo sapiens	168-173
22865284-8	2014	Deltamethrin significantly increased the TNF-alpha.	decamethrin	0-12	tumor necrosis factor	Rattus norvegicus	41-50
24079995-2	2013	In primary culture of rat cortical neurons, the type II pyrethroid deltamethrin (DM) markedly enhances the expression of the mRNA of brain-derived neurotrophic factor (BDNF) and exerts neurotrophic effects.	decamethrin	67-79	brain-derived neurotrophic factor	Rattus norvegicus	133-166
24079995-2	2013	In primary culture of rat cortical neurons, the type II pyrethroid deltamethrin (DM) markedly enhances the expression of the mRNA of brain-derived neurotrophic factor (BDNF) and exerts neurotrophic effects.	decamethrin	67-79	brain-derived neurotrophic factor	Rattus norvegicus	168-172
24079995-2	2013	In primary culture of rat cortical neurons, the type II pyrethroid deltamethrin (DM) markedly enhances the expression of the mRNA of brain-derived neurotrophic factor (BDNF) and exerts neurotrophic effects.	decamethrin	81-83	brain-derived neurotrophic factor	Rattus norvegicus	133-166
24079995-2	2013	In primary culture of rat cortical neurons, the type II pyrethroid deltamethrin (DM) markedly enhances the expression of the mRNA of brain-derived neurotrophic factor (BDNF) and exerts neurotrophic effects.	decamethrin	81-83	brain-derived neurotrophic factor	Rattus norvegicus	168-172
24079995-5	2013	Intraperitoneal administration of DM (5 and 10mg/kg), but not of PM (10mg/kg), increased the expression of BDNF mRNA in the hippocampus.	decamethrin	34-36	brain derived neurotrophic factor	Mus musculus	107-111
24079995-7	2013	This effect of DM was inhibited by intracerebroventricular injection of K252a, which is an inhibitor of the BDNF receptor TrkB, indicating that the antidepressant-like effects of DM are mediated by BDNF/TrkB signaling pathways.	decamethrin	15-17	brain derived neurotrophic factor	Mus musculus	108-112
23973721-1	2013	Differential expression of ubiquitin was previously reported between Plutella xylostella strains that are resistant or susceptible to the pesticide deltamethrin (DM).	decamethrin	148-160	LOW QUALITY PROTEIN: ubiquitin-60S ribosomal protein L40	Plutella xylostella	27-36
22634058-6	2013	Pyrethroids, e.g. deltamethrin, fenvalerate and lambda-cyhalothrin, potently inhibited CYP2D6.	decamethrin	18-30	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	87-93
23829777-0	2014	Effect of the pesticide, deltamethrin, on Ca2+ signaling and apoptosis in OC2 human oral cancer cells.	decamethrin	25-37	one cut homeobox 2	Homo sapiens	74-77
23829777-3	2014	This study explored the effects of deltamethrin on [Ca(2+)]i and viability in OC2 human oral cancer cells.	decamethrin	35-47	one cut homeobox 2	Homo sapiens	78-81
23829777-4	2014	Deltamethrin, at concentrations of 5-10 muM, increased [Ca(2+)]i in a concentration-dependent manner.	decamethrin	0-12	latexin	Homo sapiens	40-43
23829777-7	2014	In Ca(2+)-free medium, 10-muM deltamethrin pretreatment inhibited the [Ca(2+)]i rise induced by the endoplasmic reticulum Ca(2+) pump inhibitor, 2,5-di-tert-butylhydroquinone (BHQ).	decamethrin	30-42	latexin	Homo sapiens	26-29
23829777-10	2014	At concentrations between 20 and 100 muM, deltamethrin killed cells in a concentration-dependent manner.	decamethrin	42-54	latexin	Homo sapiens	37-40
23829777-13	2014	Annexin V/propidium iodide staining data suggest that deltamethrin (40-60 muM) induced apoptosis in a concentration-dependent manner.	decamethrin	54-66	annexin A5	Homo sapiens	0-9
23829777-13	2014	Annexin V/propidium iodide staining data suggest that deltamethrin (40-60 muM) induced apoptosis in a concentration-dependent manner.	decamethrin	54-66	latexin	Homo sapiens	74-77
23829777-14	2014	To conclude, in OC2 cells, deltamethrin evoked a [Ca(2+)]i rise by inducing PLC-independent Ca(2+) release from the endoplasmic reticulum and Ca(2+) entry by nifedipine-sensitive Ca(2+) channels.	decamethrin	27-39	one cut homeobox 2	Homo sapiens	16-19
24079995-7	2013	This effect of DM was inhibited by intracerebroventricular injection of K252a, which is an inhibitor of the BDNF receptor TrkB, indicating that the antidepressant-like effects of DM are mediated by BDNF/TrkB signaling pathways.	decamethrin	15-17	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	122-126
24079995-7	2013	This effect of DM was inhibited by intracerebroventricular injection of K252a, which is an inhibitor of the BDNF receptor TrkB, indicating that the antidepressant-like effects of DM are mediated by BDNF/TrkB signaling pathways.	decamethrin	15-17	brain derived neurotrophic factor	Mus musculus	198-202
24079995-7	2013	This effect of DM was inhibited by intracerebroventricular injection of K252a, which is an inhibitor of the BDNF receptor TrkB, indicating that the antidepressant-like effects of DM are mediated by BDNF/TrkB signaling pathways.	decamethrin	15-17	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	203-207
23973721-2	2013	This finding hinted at the potential involvement of ubiquitin in deltamethrin resistance, a theory that demanded further testing.	decamethrin	65-77	LOW QUALITY PROTEIN: ubiquitin-60S ribosomal protein L40	Plutella xylostella	52-61
23973721-3	2013	Real-time PCR analyses revealed that one of the ubiquitin genes, UBL40, was overexpressed in the deltamethrin-resistant strain during the fourth instar.	decamethrin	97-109	LOW QUALITY PROTEIN: ubiquitin-60S ribosomal protein L40	Plutella xylostella	48-57
23764339-10	2013	Furthermore, the substitution of isoleucine with valine, but not with methionine nor leucine, at the corresponding position in a rat skeletal muscle sodium channel, rNav1.4, enhanced channel sensitivity to deltamethrin.	decamethrin	206-218	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	165-172
23740241-0	2013	Effect of large-scale installation of deltamethrin-impregnated screens and curtains in Bam, a major focus of anthroponotic cutaneous leishmaniasis in Iran.	decamethrin	38-50	structural maintenance of chromosomes 3	Homo sapiens	87-90
23740241-1	2013	INTRODUCTION: Installation of deltamethrin-impregnated screens and curtains was assessed as a preventive measure against transmission of anthroponotic cutaneous leishmaniasis (ACL) by Phlebotomus sergenti in Bam, a well-known focus of ACL in Iran with a population of nearly 100,000.	decamethrin	30-42	structural maintenance of chromosomes 3	Homo sapiens	208-211
23762443-0	2013	Identification of proteasome subunit beta type 6 (PSMB6) associated with deltamethrin resistance in mosquitoes by proteomic and bioassay analyses.	decamethrin	73-85	proteasome 20S subunit beta 6	Homo sapiens	18-48
23762443-0	2013	Identification of proteasome subunit beta type 6 (PSMB6) associated with deltamethrin resistance in mosquitoes by proteomic and bioassay analyses.	decamethrin	73-85	proteasome 20S subunit beta 6	Homo sapiens	50-55
23076637-7	2013	RT-PCR demonstrated significant up-regulation in testicular mRNA for glutathione-S-transferase and heat-shock protein-70 (HSP-70), whereas steroidogenic acute regulatory (StAR) protein was down-regulated after deltamethrin exposure.	decamethrin	210-222	steroidogenic acute regulatory protein	Rattus norvegicus	171-175
23585199-0	2013	Effect of glutathione depletion on Nrf2/ARE activation by deltamethrin in PC12 Cells.	decamethrin	58-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	35-39
23585199-2	2013	Previously, we have reported that in PC12 cells, Nrf2 can be triggered by deltamethrin (DM), a commonly used pyrethroid insecticide.	decamethrin	74-86	NFE2 like bZIP transcription factor 2	Rattus norvegicus	49-53
23585199-2	2013	Previously, we have reported that in PC12 cells, Nrf2 can be triggered by deltamethrin (DM), a commonly used pyrethroid insecticide.	decamethrin	88-90	NFE2 like bZIP transcription factor 2	Rattus norvegicus	49-53
23585199-4	2013	Here we studied the effects of cell glutathione (GSH) depletion on Nrf2 activation by DM.	decamethrin	86-88	NFE2 like bZIP transcription factor 2	Rattus norvegicus	67-71