PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24201003-5	2014	Next, the cis-diol group of ribose sugar at the end of the miRNAs chain allowed 3-aminophenylboronic acid (APBA)/biotin-modified multifunctional AuNPs (denoted as APBA-biotin-AuNPs) to be attached through the formation of a boronate ester covalent bond, which facilitated the capture of streptavidin-conjugated alkaline phosphatase (SA-ALP) via the biotin-streptavidin interaction.	Ribose	28-34	alkaline phosphatase, placental	Homo sapiens	311-331
24127424-6	2013	Here, we report on the accurate synthesis of methylated, phosphorylated, and phosphonated serinyl-derived tRNA(Sec) mimics that contain a hydrolysis-resistant ribose 3"-amide linkage instead of the natural ester bond.	Ribose	159-165	mitochondrially encoded tRNA glycine	Homo sapiens	106-115
24220328-7	2014	This was also true for the pentose pathway ( PGD, TKT), which is involved in synthesis of ribose precursors of RNA and DNA.	Ribose	90-96	transketolase	Bos taurus	50-53
23897466-0	2013	Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism.	Ribose	49-55	sirtuin 3	Homo sapiens	20-29
24350055-1	2013	Poly(ADP-ribose) polymerases (PARPs) are DNA-dependent nuclear enzymes that transfer negatively charged ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide (NAD(+)) to a variety of protein substrates, altering protein-protein and protein-DNA interactions.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	30-35
24021463-6	2013	The crystal structures of compound 26 and the corresponding PRPP-derived ribose adduct in complex with NAMPT were also obtained.	Ribose	73-79	nicotinamide phosphoribosyltransferase	Homo sapiens	103-108
24088713-0	2013	SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress.	Ribose	66-72	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	0-6
24088713-0	2013	SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress.	Ribose	66-72	poly(ADP-ribose) polymerase 1	Homo sapiens	32-37
24059452-5	2013	CD38, a membrane glycoprotein, catalyzes synthesis of cyclic ADP-ribose and facilitates oxytocin (OT) secretion due to cyclic ADP-ribose-dependent increases in cytosolic free calcium concentrations in oxytocinergic neurons in the hypothalamus.	Ribose	65-71	CD38 antigen	Mus musculus	0-4
23880539-4	2013	This binding mode is in contrast to that of known ALK inhibitors such as Crizotinib and NVP-TAE684 which occupy the ribose binding pocket, close to DFG motif.	Ribose	116-122	ALK receptor tyrosine kinase	Homo sapiens	50-53
23811687-6	2013	By stimulating G6PD, TAp73 increases PPP flux and directs glucose to the production of NADPH and ribose, for the synthesis of macromolecules and detoxification of reactive oxygen species (ROS).	Ribose	97-103	glucose-6-phosphate dehydrogenase	Homo sapiens	15-19
23734017-2	2013	The mammalian NAD-glycohydrolase CD38 catalyzes formation of cADPR by removing nicotinamide and forming a new intramolecular bond between N1 of adenine and C1 of the "northern" ribose.	Ribose	177-183	CD38 molecule	Homo sapiens	33-37
23967283-8	2013	[1,2- (13)C2]-glucose tracer experiments demonstrated that the oxidative branch of PPP initiated by glucose-6-phosphate dehydrogenase activity is preferentially utilized for ribose production (56-66%) that produces increased amounts of ribose necessary for growth and NADPH.	Ribose	236-242	glucose-6-phosphate dehydrogenase	Homo sapiens	100-133
23785461-5	2013	One of the downstream metabolites of this pathway, D-ribose, has been reported to alleviate symptoms of myalgia in patients with a congenital loss of AMPD1.	Ribose	51-59	adenosine monophosphate deaminase 1	Homo sapiens	150-155
23967283-8	2013	[1,2- (13)C2]-glucose tracer experiments demonstrated that the oxidative branch of PPP initiated by glucose-6-phosphate dehydrogenase activity is preferentially utilized for ribose production (56-66%) that produces increased amounts of ribose necessary for growth and NADPH.	Ribose	174-180	glucose-6-phosphate dehydrogenase	Homo sapiens	100-133
23483050-4	2013	(13)C-labeling experiments using [1-(13)C] ribose showed that the formation pathway of DPL C was different from those of DPLs A and B.	Ribose	43-49	prion like protein doppel	Homo sapiens	87-90
23483050-5	2013	In addition, (13)C-labeling experiments using [u-(13)C5] ribose and [1-(13)C] lysine showed that C-6 of a methine moiety in DPL C was derived from C-5 of ribose or acetic acid in buffer.	Ribose	57-63	complement C6	Homo sapiens	97-100
23483050-5	2013	In addition, (13)C-labeling experiments using [u-(13)C5] ribose and [1-(13)C] lysine showed that C-6 of a methine moiety in DPL C was derived from C-5 of ribose or acetic acid in buffer.	Ribose	57-63	prion like protein doppel	Homo sapiens	124-127
23921124-4	2013	Conversely, overexpression of miR-1 and miR-206 decreased the expression of metabolic genes and dramatically impaired NADPH production, ribose synthesis, and in vivo tumor growth in mice.	Ribose	136-142	microRNA 206	Mus musculus	40-47
23670538-5	2013	Downstream steps, which involve the purine nucleoside phosphorylase, Pnp1, and pyrimidine nucleoside hydrolase, Urh1, funnel ribose into the nonoxidative pentose phosphate pathway.	Ribose	125-131	purine-nucleoside phosphorylase	Saccharomyces cerevisiae S288C	69-73
23670538-5	2013	Downstream steps, which involve the purine nucleoside phosphorylase, Pnp1, and pyrimidine nucleoside hydrolase, Urh1, funnel ribose into the nonoxidative pentose phosphate pathway.	Ribose	125-131	trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase	Saccharomyces cerevisiae S288C	112-116
23615669-2	2013	The low activity of pyruvate kinase, reexpressed in its embryonic isoform PKM2, generates a bottleneck at the end of glycolysis, which reorients glucose catabolism towards formation of molecules implied in numerous synthesis: ribose for nucleic acids, glycerol for lipid synthesis, etc.	Ribose	226-232	pyruvate kinase M1/2	Homo sapiens	74-78
23501114-5	2013	The incorporation of a d-ribofuranose into the hinged hybrids provided the corresponding nucleosides with the beta configuration, one of which inhibited HCV replication with an EC50 value of 20 muM.	Ribose	23-37	latexin	Homo sapiens	194-197
23524370-3	2013	In this work, we present a computational study on the hydrolysis of glycosidic ribose-ribose bond catalyzed by PARG using hybrid density functional theory (DFT) methods.	Ribose	79-85	poly(ADP-ribose) glycohydrolase	Homo sapiens	111-115
23454361-0	2013	Crystal structure analysis of human Sirt2 and its ADP-ribose complex.	Ribose	54-60	sirtuin 2	Homo sapiens	36-41
23795283-0	2013	Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L.	Ribose	51-57	DOT1 like histone lysine methyltransferase	Homo sapiens	109-114
23467693-2	2013	In order to investigate the biological effects of degradation of poly(ADP-ribose), knockdown of the poly(ADP-ribose) glycohydrolase (PARG) gene was performed by introducing a short interfering RNA (siRNA)-pool into HeLa S3 cells.	Ribose	74-80	poly(ADP-ribose) glycohydrolase	Homo sapiens	133-137
23438649-4	2013	In conjunction with a phosphopeptide-like enrichment strategy that captures the ribose-5"-phosphate peptides, we identified eight novel sites of PARP-1 automodification, confirmed the localization of two sites previously reported, and provided evidence for two additional targeted peptides with ambiguous modification site assignments.	Ribose	80-87	poly(ADP-ribose) polymerase 1	Homo sapiens	145-151
23524370-3	2013	In this work, we present a computational study on the hydrolysis of glycosidic ribose-ribose bond catalyzed by PARG using hybrid density functional theory (DFT) methods.	Ribose	86-92	poly(ADP-ribose) glycohydrolase	Homo sapiens	111-115
22897592-3	2013	The main cause of Akt inhibition is considered to be the strong hydrogen bond between N-H and Thr-291, and hydrophobic interactions at Glu-234, and Asp-292 in the vicinity, which is usually occupied by the ribose of ATP, and interaction with residue Phe-161, thus leading to a significant conformational change in that particular portion of the protein.	Ribose	206-212	AKT serine/threonine kinase 1	Homo sapiens	18-21
23716697-3	2013	Here, we report that ADP-ribosylation of CtBP1-S/BARS by BFA occurs via a nonconventional mechanism that comprises two steps: (i) synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket.	Ribose	153-159	C-terminal binding protein 1	Homo sapiens	41-46
23716697-3	2013	Here, we report that ADP-ribosylation of CtBP1-S/BARS by BFA occurs via a nonconventional mechanism that comprises two steps: (i) synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket.	Ribose	153-159	C-terminal binding protein 1	Homo sapiens	49-53
23438786-9	2013	Treatment with D-ribose attenuated the increase in serum and renal TNF-alpha concentrations, renal MCP-1 concentration, and renal ICAM-1 mRNA expression.	Ribose	15-23	tumor necrosis factor	Mus musculus	67-76
23438786-9	2013	Treatment with D-ribose attenuated the increase in serum and renal TNF-alpha concentrations, renal MCP-1 concentration, and renal ICAM-1 mRNA expression.	Ribose	15-23	chemokine (C-C motif) ligand 2	Mus musculus	99-104
23438786-9	2013	Treatment with D-ribose attenuated the increase in serum and renal TNF-alpha concentrations, renal MCP-1 concentration, and renal ICAM-1 mRNA expression.	Ribose	15-23	intercellular adhesion molecule 1	Mus musculus	130-136
23590158-1	2013	BACKGROUND/AIMS: The simultaneous supplementation of creatine and D-ribose has been shown to reduce apoptosis in vitro in non-irreversibly injured cultured ischemic cardiomyocytes through down-regulation of the signaling mechanisms governing adenosine monophosphate-activated protein kinase (AMPK) and protein kinase B (Akt).	Ribose	66-74	thymoma viral proto-oncogene 1	Mus musculus	320-323
23590158-8	2013	Furthermore, creatine + D-ribose diminished the hypoxia-induced increases in the activity of AMPK, Akt and JNK, but not of ERK.	Ribose	24-32	thymoma viral proto-oncogene 1	Mus musculus	99-102
23590158-8	2013	Furthermore, creatine + D-ribose diminished the hypoxia-induced increases in the activity of AMPK, Akt and JNK, but not of ERK.	Ribose	24-32	mitogen-activated protein kinase 8	Mus musculus	107-110
24193262-2	2013	Transketolase-dependent reactions supply malignant tumors with ribose and NADPH.	Ribose	63-69	transketolase	Homo sapiens	0-13
22869598-5	2012	Mutations that mimic the negative charge of ADP-ribose destabilized substrate binding and interfered with interdomain allosteric coupling, marking ADP ribosylation as a rapid posttranslational mechanism for reversible inactivation of BiP.	Ribose	48-54	heat shock protein 5	Mus musculus	234-237
23038248-8	2012	Administration of PARP inhibitors confirms that poly(ADP-ribose) facilitates PARP-1 association with XPA in whole cell extracts, in isolated chromatin complexes, and in vitro.	Ribose	57-63	poly(ADP-ribose) polymerase 1	Homo sapiens	18-22
23038248-8	2012	Administration of PARP inhibitors confirms that poly(ADP-ribose) facilitates PARP-1 association with XPA in whole cell extracts, in isolated chromatin complexes, and in vitro.	Ribose	57-63	poly(ADP-ribose) polymerase 1	Homo sapiens	77-83
23038248-8	2012	Administration of PARP inhibitors confirms that poly(ADP-ribose) facilitates PARP-1 association with XPA in whole cell extracts, in isolated chromatin complexes, and in vitro.	Ribose	57-63	XPA, DNA damage recognition and repair factor	Homo sapiens	101-104
23010590-0	2012	Structural insight into the interaction of ADP-ribose with the PARP WWE domains.	Ribose	47-53	poly(ADP-ribose) polymerase 1	Homo sapiens	63-67
23010590-5	2012	The present structural information sheds light on the ADP-ribose recognition modes by the PARP WWE domains.	Ribose	58-64	poly(ADP-ribose) polymerase 1	Homo sapiens	90-94
22895883-2	2012	Isonucleoside is a type of nucleoside analogue, in which the nucleobase is moved from C-1 to other positions of ribose.	Ribose	112-118	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	86-89
22854955-1	2012	Poly(ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear protein that binds chromatin and catalyzes the transfer of ADP-ribose groups to itself and to numerous target proteins upon interacting with damaged DNA.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	31-37
22821820-1	2012	To enhance the activity of transketolase towards nonphosphorylated substrates and enlarge the scope of its substrates, notably to long polyol aldehyde acceptors (D-ribose or D-glucose), a rational design-supported evolution strategy was applied.	Ribose	162-170	transketolase	Homo sapiens	27-40
22438109-3	2012	We find that the glucose-6-phosphate (G6P) and pseudo catabolic/anabolic branch points are flexible in the D: -ribose-producing tkt deficient strain of B. pumilus.	Ribose	111-117	AKO65_RS14630	Bacillus pumilus	128-131
22742766-9	2012	Hence, regardless of the ribose"s configuration within the bound SRH substrate, LuxS is able to catalyze the conversion of SRH to a common 2-keto-SRH intermediate.	Ribose	25-31	Lutheran suppressor, X-linked	Homo sapiens	80-84
22839996-1	2012	BACKGROUND: Cell death induced by poly(ADP-ribose) (PAR) and mediated by apoptosis-inducing factor (AIF) is well-characterized in models of ischemic tissue injury, but their roles in cancer cell death after chemotherapy are less understood.	Ribose	42-50	apoptosis inducing factor mitochondria associated 1	Homo sapiens	100-103
22551018-5	2012	The ribose binding pocket of CHK1 was targeted to generate inhibitors with excellent cellular potency and selectivity over CDK1and IKKbeta, key features lacking from the initial compounds.	Ribose	4-10	checkpoint kinase 1	Homo sapiens	29-33
22386868-3	2012	Modifications at the wobble uridine (U34) of tRNAs reading two degenerate codons ending in purine are complex and result from the activity of two multi-enzyme pathways, the IscS-MnmA and MnmEG pathways, which independently work on positions 2 and 5 of the U34 pyrimidine ring, respectively, and from a third pathway, controlled by TrmL (YibK), that modifies the 2"-hydroxyl group of the ribose.	Ribose	387-393	NFS1 cysteine desulfurase	Homo sapiens	173-177
22713970-1	2012	Poly(ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose groups to target proteins and thereby affect various nuclear and cytoplasmic processes.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	30-35
22541435-5	2012	These studies also reveal that oncogenic Kras promotes ribose biogenesis.	Ribose	55-61	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	41-45
22541435-6	2012	Unlike canonical models, we demonstrate that Kras(G12D) drives glycolysis intermediates into the nonoxidative PPP, thereby decoupling ribose biogenesis from NADP/NADPH-mediated redox control.	Ribose	134-140	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	45-49
22399070-4	2012	We predict that Escherichia coli YbiA and related families of domains from diverse bacteria, eukaryotes, large DNA viruses and single strand RNA viruses are previously unrecognized components of NAD-utilizing pathways that probably operate on ADP-ribose derivatives.	Ribose	247-253	hypothetical protein YbiA	Escherichia coli	33-37
22551018-5	2012	The ribose binding pocket of CHK1 was targeted to generate inhibitors with excellent cellular potency and selectivity over CDK1and IKKbeta, key features lacking from the initial compounds.	Ribose	4-10	cyclin dependent kinase 1	Homo sapiens	123-127
22551018-5	2012	The ribose binding pocket of CHK1 was targeted to generate inhibitors with excellent cellular potency and selectivity over CDK1and IKKbeta, key features lacking from the initial compounds.	Ribose	4-10	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	131-138
22139586-1	2012	Diphtheria toxin (DT) and its N-terminal fragment A (FA) catalyse the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD) into a covalent linkage with eukaryotic elongation factor 2 (eEF2).	Ribose	90-96	eukaryotic translation elongation factor 2	Homo sapiens	176-206
22139586-1	2012	Diphtheria toxin (DT) and its N-terminal fragment A (FA) catalyse the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD) into a covalent linkage with eukaryotic elongation factor 2 (eEF2).	Ribose	90-96	eukaryotic translation elongation factor 2	Homo sapiens	208-212
22033928-0	2011	Connexin-43 hemichannels mediate cyclic ADP-ribose generation and its Ca2+-mobilizing activity by NAD+/cyclic ADP-ribose transport.	Ribose	44-50	gap junction protein, alpha 1	Mus musculus	0-11
22458568-2	2012	We designed and synthesized a series of novel compounds that display potent binding affinity against eIF4E despite their lack of a ribose moiety, phosphate, and positive charge as present in m7-GMP.	Ribose	131-137	eukaryotic translation initiation factor 4E	Oryctolagus cuniculus	101-106
23236422-0	2012	A cell permeable NPE caged ADP-ribose for studying TRPM2.	Ribose	31-37	transient receptor potential cation channel subfamily M member 2	Homo sapiens	51-56
22844406-4	2012	Since aspartic acid and glutamic acid residues are acceptors of the ADP ribose moiety transferred by PARP-1, deletion of the evolutionarily conserved C-terminal Glu-rich tail of HOXB7 dramatically attenuates ADP-ribosylation of HOXB7 by PARP-1.	Ribose	72-78	poly(ADP-ribose) polymerase 1	Homo sapiens	101-107
22844406-4	2012	Since aspartic acid and glutamic acid residues are acceptors of the ADP ribose moiety transferred by PARP-1, deletion of the evolutionarily conserved C-terminal Glu-rich tail of HOXB7 dramatically attenuates ADP-ribosylation of HOXB7 by PARP-1.	Ribose	72-78	homeobox B7	Homo sapiens	178-183
22069261-5	2011	We also studied the Bcl-2 family molecules involved in killing by using high concentrations of reducing sugars such as glucose or ribose.	Ribose	130-136	BCL2 apoptosis regulator	Homo sapiens	20-25
23050038-2	2012	The nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP1), which catalyzes the synthesis of the biopolymer poly(ADP-ribose), exhibits an essential role in both processes.	Ribose	28-34	poly(ADP-ribose) polymerase 1	Homo sapiens	50-55
21866443-3	2011	Of mutant clones, developed through radiation mutagenesis, P2-M2 utilized ribose with GDH specific activity of 0.57 U/mg protein, P4-M3 grown on glucose gave 1.5 U/mg protein and P4-M5 had high activities, when grown on galactose, maltose, and lactose.	Ribose	74-80	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	86-89
21997878-4	2011	Activation of FGF-ERK1/2 pathway was necessary for the activity of poly(ADP-ribose) polymerase-1 (PARP-1), a conserved nuclear protein catalyzing polymerization of ADP-ribose units.	Ribose	76-82	mitogen-activated protein kinase 3	Homo sapiens	18-24
21997878-4	2011	Activation of FGF-ERK1/2 pathway was necessary for the activity of poly(ADP-ribose) polymerase-1 (PARP-1), a conserved nuclear protein catalyzing polymerization of ADP-ribose units.	Ribose	76-82	poly(ADP-ribose) polymerase 1	Homo sapiens	98-104
22000507-2	2011	A recent study in Nature (Slade et al., 2011) reports the structure of PAR glycohydrolase (PARG), revealing unexpected similarity to the ubiquitous ADP-ribose-binding macrodomains.	Ribose	152-158	poly(ADP-ribose) glycohydrolase	Homo sapiens	71-89
22039965-5	2011	A methanocarba (bicyclo[3.1.0]hexane) ring system in place of ribose maintained a North conformation that is preferred at the A3AR.	Ribose	62-68	adenosine A3 receptor	Mus musculus	126-130
21905640-3	2011	When D-arabinose and D-ribose were silylated with tert-butyldiphenylsilyl chloride in pyridine at the hydroxyl groups at C-5 and acetylated at the other ones in a one-pot reaction, mixtures of anomeric 1-O-acetyl derivatives were obtained.	Ribose	21-29	complement C5	Homo sapiens	121-124
22000507-2	2011	A recent study in Nature (Slade et al., 2011) reports the structure of PAR glycohydrolase (PARG), revealing unexpected similarity to the ubiquitous ADP-ribose-binding macrodomains.	Ribose	152-158	poly(ADP-ribose) glycohydrolase	Homo sapiens	91-95
21812934-1	2011	Poly(ADP-ribose) polymerase-2 (PARP2) belongs to the ADP-ribosyltransferase family of enzymes that catalyze the addition of ADP-ribose units to acceptor proteins, thus affecting many diverse cellular processes.	Ribose	9-15	poly(ADP-ribose) polymerase 2	Homo sapiens	31-36
21864514-4	2011	We find that the glycating agent d-ribose interacts with human beta(2)M to generate AGEs that form aggregates in a time-dependent manner.	Ribose	33-41	beta-2-microglobulin	Homo sapiens	63-71
21864514-8	2011	In other words, d-ribose reacts with beta(2)M and induces the ribosylated protein to form granular aggregates with high cytotoxicity through a ROS-mediated pathway.	Ribose	16-24	beta-2-microglobulin	Homo sapiens	37-45
21855358-6	2011	The structure-activity relationship of the designed inhibitors highlights the importance of both the homocysteine and ribose moieties for high-affinity binding to LuxS active site.	Ribose	118-124	Lutheran suppressor, X-linked	Homo sapiens	163-167
21873463-3	2011	Occasionally, nucleobases in these regions populate the syn conformation wherein the base resides close to or over the ribose sugar, which leads to a more compact state.	Ribose	119-125	synemin	Homo sapiens	56-59
21735511-4	2011	We also investigate the SERS spectrum of adenine at the junction between two Ag(20) clusters and demonstrate that adenine can bind to the clusters through N3 and the external amino group, while dAMP can be adsorbed on the cluster in an end-on orientation with the ribose and phosphate groups near to or away from the silver cluster.	Ribose	264-270	Amphiphysin	Drosophila melanogaster	194-198
21820018-8	2011	Lsc3 and LscA could both transfructosylate D-xylose, D-fucose, L- and D-arabinose, D-ribose, D-sorbitol, xylitol, xylobiose, D-mannitol, D-galacturonic acid and methyl-alpha-D-glucopyranoside and heterooligofructans with degree of polymerization up to 5 were detected.	Ribose	83-91	glycoside hydrolase family 68 protein	Pseudomonas syringae pv. tomato str. DC3000	0-4
21892188-3	2011	PAR glycohydrolase (PARG) is the only protein capable of specific hydrolysis of the ribose-ribose bonds present in PAR chains; its deficiency leads to cell death.	Ribose	84-90	poly(ADP-ribose) glycohydrolase	Homo sapiens	0-18
21892188-3	2011	PAR glycohydrolase (PARG) is the only protein capable of specific hydrolysis of the ribose-ribose bonds present in PAR chains; its deficiency leads to cell death.	Ribose	84-90	poly(ADP-ribose) glycohydrolase	Homo sapiens	20-24
21892188-3	2011	PAR glycohydrolase (PARG) is the only protein capable of specific hydrolysis of the ribose-ribose bonds present in PAR chains; its deficiency leads to cell death.	Ribose	91-97	poly(ADP-ribose) glycohydrolase	Homo sapiens	0-18
21892188-3	2011	PAR glycohydrolase (PARG) is the only protein capable of specific hydrolysis of the ribose-ribose bonds present in PAR chains; its deficiency leads to cell death.	Ribose	91-97	poly(ADP-ribose) glycohydrolase	Homo sapiens	20-24
21892188-5	2011	We present the first PARG crystal structure (derived from the bacterium Thermomonospora curvata), which reveals that the PARG catalytic domain is a distant member of the ubiquitous ADP-ribose-binding macrodomain family.	Ribose	185-191	poly(ADP-ribose) glycohydrolase	Homo sapiens	21-25
21892188-5	2011	We present the first PARG crystal structure (derived from the bacterium Thermomonospora curvata), which reveals that the PARG catalytic domain is a distant member of the ubiquitous ADP-ribose-binding macrodomain family.	Ribose	185-191	poly(ADP-ribose) glycohydrolase	Homo sapiens	121-125
21574903-4	2011	RESULTS: Cytokines shown to be upregulated early (hours) following irradiation (interleukin [IL]6, keratinocyte chemoattractant [KC], IL1B, and IL1R2) demonstrated increases in messenger ribose nucleic acid (mRNA) expression at late time points, beginning at nine months.	Ribose	187-193	interleukin 1 receptor, type II	Mus musculus	144-149
21735511-5	2011	In contrast to the adenine-Ag(20) complexes, the dAMP-Ag(20) complexes produce new and strong bands in the low- or high-wavenumber region of the Raman spectra, due to vibrations of the ribose and phosphate groups.	Ribose	185-191	Amphiphysin	Drosophila melanogaster	49-53
21641214-2	2011	It is involved in the conversion of NAD(P)(+) into cyclic ADP-ribose, NAADP(+) and ADP-ribose and the role of these metabolites in multiple Ca(2+) signaling pathways makes CD38 a novel potential pharmacological target.	Ribose	62-68	CD38 molecule	Homo sapiens	172-176
21630463-7	2011	BL0033, a component of an ATP-binding cassette (ABC) transporter, was significantly more abundant in bacteria grown on fructose and, to a lesser extent, ribose and xylose.	Ribose	153-159	substrate-binding domain-containing protein	Bifidobacterium longum NCC2705	0-6
21375718-3	2011	The mutation of cggR did not affect regulation of the gap operon, indicating a more prominent regulatory role of CggR on the gap operon under other conditions than tested (e.g. fermentation of other sugars than glucose or ribose) and when the level of the putative effector molecule FBP is reduced.	Ribose	222-228	central glycolytic genes regulator	Lactobacillus plantarum WCFS1	113-117
21498885-9	2011	ARH1 also hydrolyzed OAADPr more rapidly at alkaline pH, but cleavage of ADP-ribose-arginine was faster at neutral pH than pH 9.0.	Ribose	77-83	ADP-ribosylarginine hydrolase	Homo sapiens	0-4
21663798-7	2011	Flux through SHB17 increases when ribose demand is high relative to demand for NADPH, including during ribosome biogenesis in metabolically synchronized yeast cells.	Ribose	34-40	sedoheptulose-bisphosphatase	Saccharomyces cerevisiae S288C	13-18
21709234-9	2011	These findings establish an unsuspected role for ADP-ribose and ROS-mediated cation flux for innate immunity, opening up unique possibilities for immunomodulatory intervention through TRPM2.	Ribose	53-59	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	184-189
21310715-2	2011	We report the validation of a human enzyme that methylates the ribose of the second transcribed nucleotide encoded by FTSJD1, henceforth renamed HMTR2 to reflect function.	Ribose	63-69	cap methyltransferase 2	Homo sapiens	118-124
21310715-2	2011	We report the validation of a human enzyme that methylates the ribose of the second transcribed nucleotide encoded by FTSJD1, henceforth renamed HMTR2 to reflect function.	Ribose	63-69	cap methyltransferase 2	Homo sapiens	145-150
21317046-7	2011	Indeed we demonstrated that Che-1 protein co-immunoprecipitates with ADP-ribose polymers and that PARP-1 directly interacts with Che-1, promoting its modification in vitro and in vivo.	Ribose	73-79	apoptosis antagonizing transcription factor	Homo sapiens	28-33
20463145-11	2010	hRFT-mediated uptake of [3H]riboflavin was inhibited by some riboflavin analogs, but not D-ribose, organic ions, or other vitamins.	Ribose	89-97	methyl-CpG binding domain protein 1	Homo sapiens	0-4
21870258-2	2011	PARP catalyzes the addition of ADP-ribose molecules (pADPr) to the target proteins, a process termed poly-ADP-ribosylation.	Ribose	35-41	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
20942953-1	2010	BACKGROUND: The poly(ADP-ribose) polymerase (PARP) superfamily was originally identified as enzymes that catalyze the attachment of ADP-ribose subunits to target proteins using NAD+ as a substrate.	Ribose	25-31	poly(ADP-ribose) polymerase 1	Homo sapiens	45-49
21217758-0	2011	Ribose 2"-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.	Ribose	0-6	interferon induced with helicase C domain 1	Homo sapiens	129-133
21115249-1	2011	SAR studies and optimization of various modified Hygromycin A fluoroalkyl ethers, which led to the discovery of the highly potent 4"-(2-cyclopropyl-2-fluoroethyl ether) antibacterial CE-156811 (1) derived from truncation of the ribose ring and difluorination of the phenyl found in Hygromycin A, are discussed.	Ribose	228-234	sarcosine dehydrogenase	Homo sapiens	0-3
20828700-1	2010	Non-enzymatic posttranslational modifications of bovine serum albumin (BSA) by various oxo-compounds (glucose, ribose, glyoxal and glutardialdehyde) have been investigated using high-performance liquid chromatography (HPLC) and capillary zone electrophoresis (CZE).	Ribose	111-117	albumin	Homo sapiens	56-69
20846642-5	2010	In addition, syn-diaxial chelation (kappaO(2,4)) was observed for the ribopyranoside and the xylopyranoside.	Ribose	70-84	synemin	Homo sapiens	13-16
21036084-7	2010	Additionally, the ribose and the diphosphate units were found to play more important roles in the CHIKV nsP3-ADP-ribose complex, while the ter-ribose was more important in the VEEV complex.	Ribose	18-24	SH2 domain containing 3C	Homo sapiens	104-108
21036084-7	2010	Additionally, the ribose and the diphosphate units were found to play more important roles in the CHIKV nsP3-ADP-ribose complex, while the ter-ribose was more important in the VEEV complex.	Ribose	113-119	SH2 domain containing 3C	Homo sapiens	104-108
20650899-2	2010	TRPM2 channels are co-activated by intracellular Ca(2+) and ADP-ribose (ADPR) but also modulated in intact cells by several additional factors.	Ribose	64-70	transient receptor potential cation channel subfamily M member 2	Homo sapiens	0-5
20060508-4	2010	SIRT4 can transfer the ADP-ribose group from NAD(+) onto acceptor proteins.	Ribose	27-33	sirtuin 4	Homo sapiens	0-5
20525731-4	2010	In human PNP, we identified a single amino acid, Tyr-88, as a likely modulator of ribose selectivity.	Ribose	82-88	purine nucleoside phosphorylase	Homo sapiens	9-12
20679690-1	2010	Poly(ADP-ribose)polymerase-1 (PARP-1) catalyzes the polymerization of ADP-ribose units from NAD+ modules on target proteins, resulting in the attachment of linear or branched polymers.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	30-36
20565071-2	2010	Preference for the North (N) ring conformation of the ribose moiety of adenine nucleotide 3",5"-bisphosphate antagonists of the P2Y(1) receptor was established by using a ring-constrained methanocarba (a bicyclo[3.1.0]hexane) ring as a ribose substitute.	Ribose	54-60	purinergic receptor P2Y1	Homo sapiens	128-143
20565071-2	2010	Preference for the North (N) ring conformation of the ribose moiety of adenine nucleotide 3",5"-bisphosphate antagonists of the P2Y(1) receptor was established by using a ring-constrained methanocarba (a bicyclo[3.1.0]hexane) ring as a ribose substitute.	Ribose	236-242	purinergic receptor P2Y1	Homo sapiens	128-143
20439749-0	2010	Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response.	Ribose	36-42	aprataxin and PNKP like factor	Homo sapiens	65-69
20416371-9	2010	Moreover, Trx-1 activity was also significantly inhibited by in vitro ribose incubation.	Ribose	70-76	thioredoxin	Homo sapiens	10-15
20653285-4	2010	Enhancement in transformation was also observed when bovine serum albumin (BSA) exposed to ribose for short durations was incubated with plasmid in absence of the sugar.	Ribose	91-97	albumin	Homo sapiens	60-73
20411940-1	2010	The role of selected carboxylic acids and their potential to influence the glycation pattern and the enzymatic activity of lysozyme using glucose and ribose were investigated independently of the pH of the reaction medium.	Ribose	150-156	lysozyme	Homo sapiens	123-131
20411940-5	2010	The residual lysozyme activity in both oxalic acid-glucose and oxalic acid-ribose systems was >80% compared with 46 and 36% activity in the controls of glucose and ribose systems, respectively.	Ribose	75-81	lysozyme	Homo sapiens	13-21
20411940-5	2010	The residual lysozyme activity in both oxalic acid-glucose and oxalic acid-ribose systems was >80% compared with 46 and 36% activity in the controls of glucose and ribose systems, respectively.	Ribose	167-173	lysozyme	Homo sapiens	13-21
20404925-7	2010	The episomal system allowed recapitulating CTCF mediated enhancer blocking function to be dependent on poly (ADP)-ribose modification and to mediate histone deacetylation.	Ribose	114-120	CCCTC-binding factor	Homo sapiens	43-47
20439749-6	2010	Basic residues (R387 and R429 in the first and second PBZ domains, respectively) coordinate additional interactions with the phosphate backbone of ADP-ribose, suggesting that APLF binds to multiple ADP-ribose residues along PAR polymers.	Ribose	151-157	aprataxin and PNKP like factor	Homo sapiens	175-179
19796713-5	2010	In fully active CK2alpha the hinge region is open and does not anchor the ATP ribose, but alternatively it can adopt a closed conformation, form hydrogen bonds to the ribose moiety and thus retract the gamma-phospho group from its functional position.	Ribose	78-84	casein kinase 2 alpha 2	Homo sapiens	16-24
19796713-5	2010	In fully active CK2alpha the hinge region is open and does not anchor the ATP ribose, but alternatively it can adopt a closed conformation, form hydrogen bonds to the ribose moiety and thus retract the gamma-phospho group from its functional position.	Ribose	167-173	casein kinase 2 alpha 2	Homo sapiens	16-24
19959756-6	2010	In contrast, overexpression of the prosurvival protein Bcl-2 or deficiency of the apoptosis initiating BH3-only proteins Bim or Puma, or the downstream apoptosis effector Bax, markedly reduced glucose- or ribose-induced killing of islets.	Ribose	205-211	BCL2 apoptosis regulator	Homo sapiens	55-60
19697067-6	2010	However, the character of conserved residues in the predicted active site of the Trm13 family suggests it may use a different mechanism of ribose methylation than its relatives.	Ribose	139-145	tRNA:m4X modification enzyme	Saccharomyces cerevisiae S288C	81-86
20079708-2	2010	PARG hydrolyzes glycosidic linkages of poly(ADP-ribose) synthesized by PARP and liberates ADP-ribose residues.	Ribose	48-54	poly(ADP-ribose) glycohydrolase	Homo sapiens	0-4
20079708-5	2010	However, previous PARG assay systems are not appropriate for high-throughput screening because PARG activity is measured by radioactivities of ADP-ribose residues released from radioisotope (RI)-labeled poly(ADP-ribose).	Ribose	147-153	poly(ADP-ribose) glycohydrolase	Homo sapiens	95-99
20009024-0	2010	Effects of fructosamine-3-kinase deficiency on function and survival of mouse pancreatic islets after prolonged culture in high glucose or ribose concentrations.	Ribose	139-145	fructosamine 3 kinase	Mus musculus	11-32
20092359-1	2010	Poly-ADP-ribose polymerases (PARPs) catalyze transfer of ADP-ribose from NAD(+) to specific residues in their substrate proteins or to growing ADP-ribose chains.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	29-34
20140223-4	2010	Results from native- and SDS-PAGE showed that D-ribose reacted rapidly with alpha-Syn, leading to dimerization and polymerization.	Ribose	46-54	synuclein alpha	Homo sapiens	76-85
20140223-6	2010	Using Western blotting, AGEs resulting from the glycation of alpha-Syn were observed within 24 h in the presence of D-ribose, but were not observed in the presence of D-glucose.	Ribose	116-124	synuclein alpha	Homo sapiens	61-70
20140223-15	2010	CONCLUSIONS/SIGNIFICANCE: alpha-Syn is rapidly glycated in the presence of D-ribose generating molten globule-like aggregations which cause cell oxidative stress and result in high cytotoxicity.	Ribose	75-83	synuclein alpha	Homo sapiens	26-35
19900463-2	2010	In this study, we demonstrated that human DNA polymerase lambda used a novel sugar selection mechanism to discriminate against ribonucleotides, whereby the ribose 2"-hydroxyl group was excluded mostly by a backbone segment and slightly by the side chain of Y505.	Ribose	156-162	DNA polymerase lambda	Homo sapiens	42-63
19902968-6	2010	Ribose replacement of UDP with a rigid North or South methanocarba (bicyclo[3.1.0]hexane) group abolished P2Y(14) receptor agonist activity.	Ribose	0-6	purinergic receptor P2Y14	Homo sapiens	106-122
20079708-2	2010	PARG hydrolyzes glycosidic linkages of poly(ADP-ribose) synthesized by PARP and liberates ADP-ribose residues.	Ribose	48-54	poly(ADP-ribose) polymerase 1	Homo sapiens	71-75
19851050-8	2009	D-ribose significantly reduced the degree of the I/R-induced increases in renal concentrations of cytokine-induced neutrophil chemoattractant-1 (a chemotactic factor for the activation of neutrophils and chemotaxis to the site of injury) and myeloperoxidase (an indicator of neutrophils infiltration).	Ribose	0-8	C-X-C motif chemokine ligand 1	Rattus norvegicus	98-143
19711072-1	2010	Phosphoglucose isomerase-deficient (pgi1) strains of Saccharomyces cerevisiae were studied for the production of D-ribose and ribitol from D-glucose via the intermediates of the pentose phosphate pathway.	Ribose	113-121	glucose-6-phosphate isomerase	Saccharomyces cerevisiae S288C	36-40
19711072-3	2010	Overexpression of the gene encoding sugar phosphate phosphatase (DOG1) of S. cerevisiae was needed for the production of D-ribose and ribitol; however, it reduced the growth of the pgi1 strains expressing GDH2 or gapB in the presence of higher D-glucose concentrations.	Ribose	121-129	2-deoxyglucose-6-phosphatase	Saccharomyces cerevisiae S288C	65-69
19711072-4	2010	The CEN.PK2-1D laboratory strain expressing both gapB and DOG1 produced approximately 0.4 g l(-1) of D-ribose and ribitol when grown on 20 g l(-1) (w/v) D-fructose with 4 g l(-1) (w/v) D-glucose.	Ribose	101-109	2-deoxyglucose-6-phosphatase	Saccharomyces cerevisiae S288C	58-62
20068353-4	2010	pykF silencing was detected by the following features: (a) impaired growth of the strain when pykA was also disrupted and when using ribose as a non-phosphotransferase system-transporting carbon source; (b) a pattern of reduced synthesis of the full-sized pykF mRNA, mediated by reverse transcription PCR, and (c) a significant decrease in PykF activity.	Ribose	133-139	pyruvate kinase 1	Escherichia coli str. K-12 substr. MG1655	0-4
19540855-0	2010	Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-ribose or Ca(2+) concentrations is involved in autoregulation of oxytocin secretion in the hypothalamus and posterior pituitary in male mice.	Ribose	71-77	oxytocin	Mus musculus	0-8
20025604-1	2009	Poly(ADP-ribose) glycohydrolase (Parg) is the main enzyme for degradation of poly(ADP-ribose) by splitting ribose-ribose bonds.	Ribose	9-15	poly (ADP-ribose) glycohydrolase	Mus musculus	33-37
19585541-1	2009	Poly(ADP-ribose) polymerase-1 (PARP-1) is a mammalian enzyme that attaches long branching chains of ADP-ribose to specific nuclear proteins, including itself.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	31-37
19722597-5	2009	The ES-OS method is applied to a set of five biologically relevant 8-substituted GTP analogs having high energy barriers between the anti and the syn conformations of the base with respect to the ribose part.	Ribose	196-202	synemin	Homo sapiens	146-149
19682914-2	2009	In this work, we have synthesized several SRH analogues modified at the ribose C3 position as potential inhibitors of LuxS.	Ribose	72-78	Lutheran suppressor, X-linked	Homo sapiens	118-122
20671953-11	2010	However, the levels were substantially higher in Glo I lens proteins incubated with ribose.	Ribose	84-90	gulonolactone (L-) oxidase	Mus musculus	49-52
19824891-4	2009	The glucose, ribose, arabinose, xylose, and fucose derivatives showed excellent CA VI inhibitory activity, with K(i)s in the range of 0.56-5.1 nm, whereas the least active derivatives, incorporating gallactose, mannose, and rhamnose scaffolds showed inhibition constants in the range of 10.1-34.1 nm.	Ribose	13-19	carbonic anhydrase 6	Homo sapiens	80-85
19851050-8	2009	D-ribose significantly reduced the degree of the I/R-induced increases in renal concentrations of cytokine-induced neutrophil chemoattractant-1 (a chemotactic factor for the activation of neutrophils and chemotaxis to the site of injury) and myeloperoxidase (an indicator of neutrophils infiltration).	Ribose	0-8	myeloperoxidase	Rattus norvegicus	242-257
19668858-7	2009	In addition, we have characterized several unnatural enzyme products using this technique, including new products of cytidyltransferase IspD bearing erythritol, glycerol and ribose components.	Ribose	174-180	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	136-140
19558492-7	2009	Extended molecular docking of mononucleotides, dinucleotides and trinucleotides into the active site of the enzyme allowed us to better understand the guanosine specificity of RNase Sa2 and to predict possible binding subsites for the downstream base and ribose of the second and third nucleotides.	Ribose	255-261	stromal antigen 2	Homo sapiens	182-185
19680243-3	2009	Chemical PARP1 inhibitors, PARP1 knockdown and mutation of ADP-ribose-binding residues in macroH2A1.1 abrogate macrodomain recruitment.	Ribose	63-69	macroH2A.1 histone	Homo sapiens	90-101
19680243-4	2009	Notably, histone macroH2A1.1 senses PARP1 activation, transiently compacts chromatin, reduces the recruitment of DNA damage factor Ku70-Ku80 and alters gamma-H2AX patterns, whereas the splice variant macroH2A1.2, which is deficient in poly-ADP-ribose binding, does not mediate chromatin rearrangements upon PARP1 activation.	Ribose	244-250	macroH2A.1 histone	Homo sapiens	17-28
19524593-2	2009	Herein, we report the structures of E. coli FucU and mouse FucU bound to L-fucose and delineate the catalytic mechanisms underlying the interconversion between stereoisomers of fucose and ribose.	Ribose	188-194	fucose mutarotase	Mus musculus	44-48
19524593-2	2009	Herein, we report the structures of E. coli FucU and mouse FucU bound to L-fucose and delineate the catalytic mechanisms underlying the interconversion between stereoisomers of fucose and ribose.	Ribose	188-194	fucose mutarotase	Mus musculus	59-63
19517062-2	2009	Here, we show that Tau is rapidly glycated in the presence of D-ribose, resulting in oligomerization and polymerization.	Ribose	62-70	microtubule associated protein tau	Homo sapiens	19-22
19517062-9	2009	This work has demonstrated that D-ribose reacted with Tau protein rapidly, producing ThT-positive aggregations which had high cytotoxicity.	Ribose	32-40	microtubule associated protein tau	Homo sapiens	54-57
19223125-7	2009	D-ribose could potentially aid in maintaining or potentially lowering extra-cellular adenosine concentrations, aid in the flux of intracellular calcium, aid in intracellular energy production, and potentially lessen the perceived "crash" state felt by many.	Ribose	0-8	activation induced cytidine deaminase	Homo sapiens	27-30
19448666-5	2009	We demonstrate that endogenous c-myc increased (13)C labeling of ribose sugars, purines and amino acids, indicating partitioning of glucose carbons into C1/folate and pentose phosphate pathways, and increased tricarboxylic acid cycle turnover at the expense of anaplerotic flux.	Ribose	65-71	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	31-36
19407395-1	2009	Human ADP-ribosylhydrolase 1 (hARH1, ADPRH) cleaves the glycosidic bond of ADP-ribose attached to an Arg residue of a protein.	Ribose	79-85	ADP-ribosylarginine hydrolase	Homo sapiens	30-35
19362586-1	2009	Poly(ADP-ribose) polymerases (PARPs) are defined as cell signaling enzymes that catalyze the transfer of ADP-ribose units from NAD(+) to a number of acceptor proteins.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	30-35
19361992-0	2009	Enhanced activity or resistance of adenosine derivatives towards adenosine deaminase-catalyzed deamination: Influence of ribose modifications.	Ribose	121-127	adenosine deaminase	Homo sapiens	65-84
19223125-10	2009	D-ribose with caffeine may be the substrate to aid in the potential intracellular energy demand, aid in lessening the perceived unpleasant side effects of caffeine, and still preserving the desired benefits of this stimulant consumed by all of us daily.	Ribose	0-8	activation induced cytidine deaminase	Homo sapiens	47-50
19223125-10	2009	D-ribose with caffeine may be the substrate to aid in the potential intracellular energy demand, aid in lessening the perceived unpleasant side effects of caffeine, and still preserving the desired benefits of this stimulant consumed by all of us daily.	Ribose	0-8	activation induced cytidine deaminase	Homo sapiens	97-100
20183604-1	2009	On the basis of inhibitory activity of truncated cyclopentenyl cytosine against S-adenosylhomocysteine hydrolase (SAH), its fluorocyclopentenyl pyrimidine derivatives were efficiently synthesized from D-ribose via electrophilic fluorination as a key step.	Ribose	201-209	adenosylhomocysteinase	Homo sapiens	80-112
20183604-1	2009	On the basis of inhibitory activity of truncated cyclopentenyl cytosine against S-adenosylhomocysteine hydrolase (SAH), its fluorocyclopentenyl pyrimidine derivatives were efficiently synthesized from D-ribose via electrophilic fluorination as a key step.	Ribose	201-209	adenosylhomocysteinase	Homo sapiens	114-117
19039788-1	2009	Fermentation with transketolase (tkt) deficient strain of Bacillus is the only reported industrially viable process for production of D-ribose, a commercially important pentose sugar.	Ribose	134-142	AKO65_RS14630	Bacillus pumilus	18-31
19039788-1	2009	Fermentation with transketolase (tkt) deficient strain of Bacillus is the only reported industrially viable process for production of D-ribose, a commercially important pentose sugar.	Ribose	134-142	AKO65_RS14630	Bacillus pumilus	33-36
19039788-3	2009	Here we demonstrate the morphological plasticity of tkt deficient strain of Bacillus pumilus ATCC 21951 and its possible relation with D-ribose productivity, a measure of carbon flux through PPP.	Ribose	135-143	AKO65_RS14630	Bacillus pumilus	52-55
18490188-3	2009	Transketolase is an important enzyme in the non-oxidative branch of the pentose phosphate pathway (PPP), a pathway responsible for generating reducing equivalents, which is essential for energy transduction and for generating ribose for nucleic acid synthesis.	Ribose	226-232	transketolase	Homo sapiens	0-13
19194813-3	2009	The combined treated gel of SPI/MTG for 24 h/ribose was more easily digested by digestive enzymes and retained higher amounts of amino acids compared with the control Maillard gels of SPI with ribose.	Ribose	45-51	chromogranin A	Homo sapiens	28-31
19224987-8	2009	Nucleotide base and ribose modifications that convert activator RNAs into competitive inhibitors of RIG-I signaling may be useful as modulators of RIG-I-mediated innate immune responses and as tools to dissect the RNA binding and conformational events associated with signaling.	Ribose	20-26	DExD/H-box helicase 58	Homo sapiens	100-105
19224987-8	2009	Nucleotide base and ribose modifications that convert activator RNAs into competitive inhibitors of RIG-I signaling may be useful as modulators of RIG-I-mediated innate immune responses and as tools to dissect the RNA binding and conformational events associated with signaling.	Ribose	20-26	DExD/H-box helicase 58	Homo sapiens	147-152
19234185-3	2009	Although ATP acts as a soluble ligand to activate P2X(7), gating of P2X(7) by NAD(+) requires ecto-ADP-ribosyltransferase ART2.2-catalyzed transfer of the ADP-ribose moiety from NAD(+) onto Arg125 of P2X(7).	Ribose	159-165	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	68-74
19234185-3	2009	Although ATP acts as a soluble ligand to activate P2X(7), gating of P2X(7) by NAD(+) requires ecto-ADP-ribosyltransferase ART2.2-catalyzed transfer of the ADP-ribose moiety from NAD(+) onto Arg125 of P2X(7).	Ribose	159-165	ADP-ribosyltransferase 2b	Mus musculus	122-128
19234185-3	2009	Although ATP acts as a soluble ligand to activate P2X(7), gating of P2X(7) by NAD(+) requires ecto-ADP-ribosyltransferase ART2.2-catalyzed transfer of the ADP-ribose moiety from NAD(+) onto Arg125 of P2X(7).	Ribose	159-165	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	68-74
18600475-8	2009	The P2Y(14) receptor appears to be the most restrictive of the class with respect to modification of the nucleobase, ribose, and phosphate moieties.	Ribose	117-123	purinergic receptor P2Y14	Homo sapiens	4-20
19179460-4	2009	Human intelectin-1-binding to BCG was inhibited by Ca(2+)-depletion, galactofuranosyl disaccharide, ribose, or xylose, and was dependent on the trimeric structure of human intelectin-1.	Ribose	100-106	intelectin 1	Homo sapiens	6-18
19323728-4	2009	epsilon-(gamma-glutamyl)lysine bonds formed during incubation of SPI with MTG may have reduced the free amino group of SPI to take part in the Maillard reaction; nevertheless, ribose took part in the Maillard reaction and initiated the Maillard cross-linkings within the CCLA gels.	Ribose	176-182	chromogranin A	Homo sapiens	65-68
19323728-4	2009	epsilon-(gamma-glutamyl)lysine bonds formed during incubation of SPI with MTG may have reduced the free amino group of SPI to take part in the Maillard reaction; nevertheless, ribose took part in the Maillard reaction and initiated the Maillard cross-linkings within the CCLA gels.	Ribose	176-182	chromogranin A	Homo sapiens	119-122
19099445-7	2009	Substrate analogues halogenated at the C3 position of ribose were synthesized and reacted as time-dependent inhibitors of LuxS.	Ribose	54-60	Lutheran suppressor, X-linked	Homo sapiens	122-126
18798872-4	2009	Interestingly, the pyrophosphatase activity toward ADP-ribose, but not NADH, was increased in pqr-216 and Pro(35S):AtNUDX2 plants compared with control plants.	Ribose	54-61	nudix hydrolase homolog 2	Arabidopsis thaliana	115-122
18798872-8	2009	The results indicate that overexpression of AtNUDX2, encoding ADP-ribose pyrophosphatase, confers enhanced tolerance of oxidative stress on Arabidopsis plants, resulting from maintenance of NAD(+) and ATP levels by nucleotide recycling from free ADP-ribose molecules under stress conditions.	Ribose	66-72	nudix hydrolase homolog 2	Arabidopsis thaliana	44-51
19013284-4	2008	The induction of CHOP messenger RNA and apoptosis were investigated in betaHC-9 cells after the oxidative stress by hydrogen peroxide and ribose.	Ribose	138-144	DNA-damage inducible transcript 3	Mus musculus	17-21
19013284-7	2008	In betaHC-9 cells, both hydrogen peroxide and ribose obviously increased apoptotic cells, accompanied with enhanced CHOP messenger RNA expression.	Ribose	46-52	DNA-damage inducible transcript 3	Mus musculus	116-120
18638444-6	2008	Strikingly, GST-Rab7 had a marked preference for GTP with ribose ring-conjugated BODIPY FL.	Ribose	58-64	glutathione S-transferase kappa 1	Homo sapiens	12-15
19262751-9	2009	The finding that in normal cells Parp1 and ADP-ribose polymers localize on the Dnmt1 promoter raises the possibility that PARylated Parp1 marks those sequences in the genome that must remain unmethylated and protects them from methylation, thus playing a role in the epigenetic regulation of gene expression.	Ribose	47-53	DNA methyltransferase (cytosine-5) 1	Mus musculus	79-84
19262751-9	2009	The finding that in normal cells Parp1 and ADP-ribose polymers localize on the Dnmt1 promoter raises the possibility that PARylated Parp1 marks those sequences in the genome that must remain unmethylated and protects them from methylation, thus playing a role in the epigenetic regulation of gene expression.	Ribose	47-53	poly (ADP-ribose) polymerase family, member 1	Mus musculus	132-137
18638444-6	2008	Strikingly, GST-Rab7 had a marked preference for GTP with ribose ring-conjugated BODIPY FL.	Ribose	58-64	RAB7B, member RAS oncogene family	Homo sapiens	16-20
18772187-3	2008	(i) Incubation of intact tuber slices with ATP led to the formation of ADP, AMP, adenosine, adenine and ribose, indicating operation of apyrase, 5"-nucleotidase and nucleosidase.	Ribose	104-110	apyrase	Solanum tuberosum	136-143
18854029-1	2008	BACKGROUND: Human ART4, carrier of the GPI-(glycosyl-phosphatidylinositol) anchored Dombrock blood group antigens, is an apparently inactive member of the mammalian mono-ADP-ribosyltransferase (ART) family named after the enzymatic transfer of a single ADP-ribose moiety from NAD+ to arginine residues of extracellular target proteins.	Ribose	257-263	ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)	Homo sapiens	18-22
18854029-1	2008	BACKGROUND: Human ART4, carrier of the GPI-(glycosyl-phosphatidylinositol) anchored Dombrock blood group antigens, is an apparently inactive member of the mammalian mono-ADP-ribosyltransferase (ART) family named after the enzymatic transfer of a single ADP-ribose moiety from NAD+ to arginine residues of extracellular target proteins.	Ribose	257-263	ADP-ribosyltransferase 3 (inactive)	Homo sapiens	18-21
18763757-0	2008	Targeting the ribose and phosphate binding site of p38 mitogen-activated protein (MAP) kinase: synthesis and biological testing of 2-alkylsulfanyl-, 4(5)-aryl-, 5(4)-heteroaryl-substituted imidazoles.	Ribose	14-20	mitogen-activated protein kinase 14	Homo sapiens	51-54
18763757-5	2008	In contrast to other known kinase inhibitors, these novel imidazole derivatives with the substituents at the imidazole-C2-thio position may interact with the ribose as well as with the phosphate binding site of the p38 MAP kinase.	Ribose	158-164	mitogen-activated protein kinase 14	Homo sapiens	215-229
18787168-5	2008	SDN1 acts specifically on single-stranded miRNAs in vitro and is sensitive to the 2"-O-methyl modification on the 3" terminal ribose of miRNAs.	Ribose	126-132	small RNA degrading nuclease 1	Arabidopsis thaliana	0-4
18474219-7	2008	Saturation transfer to the ribose moieties is limited to the anomeric protons of E. coli SSADH suggesting that the NAD(+)/NADP(+) adenine and nicotinamide, but not the ribose moieties are important for the binding of the coenzymes.	Ribose	27-33	Succinic semialdehyde dehydrogenase	Drosophila melanogaster	89-94
18560757-1	2008	Ribokinase (RK) and adenosine kinase (AK) catalyze the phosphorylation of ribose and adenosine to ribose-5-phosphate and AMP, respectively.	Ribose	74-80	adenosine kinase	Homo sapiens	20-36
18560757-1	2008	Ribokinase (RK) and adenosine kinase (AK) catalyze the phosphorylation of ribose and adenosine to ribose-5-phosphate and AMP, respectively.	Ribose	74-80	adenosine kinase	Homo sapiens	38-40
18819082-1	2008	Fluoroneplanocin A, designed as a potent mechanism-based irreversible inhibitor of S-adenosylhomocysteine hydrolase (SAH), is synthesized from D-ribose via a key D-cyclopentenone intermediate.	Ribose	143-151	adenosylhomocysteinase	Homo sapiens	83-115
18819082-1	2008	Fluoroneplanocin A, designed as a potent mechanism-based irreversible inhibitor of S-adenosylhomocysteine hydrolase (SAH), is synthesized from D-ribose via a key D-cyclopentenone intermediate.	Ribose	143-151	adenosylhomocysteinase	Homo sapiens	117-120
18619441-3	2008	Cellular PARP-1 activity was recovered when the centrifugal sediment was recombined with the supernatant fraction containing cellular ADP-ribose oligomer acceptor proteins.	Ribose	138-144	poly(ADP-ribose) polymerase 1	Homo sapiens	9-15
18477562-10	2008	The residues in the alpha3 and alpha4 helices, the beta6 strand, the loop between 3(10) and alpha4, and the loop between alpha4 and beta5 are involved in the recognition of the phosphate and ribose moieties.	Ribose	191-197	immunoglobulin binding protein 1	Homo sapiens	31-37
18422600-3	2008	Transketolase (TKT), the reversible rate-limiting enzyme of the non-oxidative branch of the PPP, mainly responsible for ribose production, was studied as well.	Ribose	120-126	transketolase	Rattus norvegicus	0-13
18422600-3	2008	Transketolase (TKT), the reversible rate-limiting enzyme of the non-oxidative branch of the PPP, mainly responsible for ribose production, was studied as well.	Ribose	120-126	transketolase	Rattus norvegicus	15-18
18422600-8	2008	It is concluded that NADPH in (pre)neoplastic lesions is mainly produced by G6PD, whereas elevated TKT activity in (pre)neoplastic lesions is responsible for ribose formation with concomitant energy supply by glycolysis.	Ribose	158-164	transketolase	Rattus norvegicus	99-102
18422600-9	2008	The similar localization of G6PD and TKT activity suggests the channelling of substrates at this site to optimize the efficiency of NADPH and ribose synthesis.	Ribose	142-148	glucose-6-phosphate dehydrogenase	Rattus norvegicus	28-32
18422600-9	2008	The similar localization of G6PD and TKT activity suggests the channelling of substrates at this site to optimize the efficiency of NADPH and ribose synthesis.	Ribose	142-148	transketolase	Rattus norvegicus	37-40
18477562-10	2008	The residues in the alpha3 and alpha4 helices, the beta6 strand, the loop between 3(10) and alpha4, and the loop between alpha4 and beta5 are involved in the recognition of the phosphate and ribose moieties.	Ribose	191-197	immunoglobulin binding protein 1	Homo sapiens	92-98
18477562-10	2008	The residues in the alpha3 and alpha4 helices, the beta6 strand, the loop between 3(10) and alpha4, and the loop between alpha4 and beta5 are involved in the recognition of the phosphate and ribose moieties.	Ribose	191-197	immunoglobulin binding protein 1	Homo sapiens	92-98
18477562-10	2008	The residues in the alpha3 and alpha4 helices, the beta6 strand, the loop between 3(10) and alpha4, and the loop between alpha4 and beta5 are involved in the recognition of the phosphate and ribose moieties.	Ribose	191-197	tubulin beta 4A class IVa	Homo sapiens	132-137
18079486-4	2008	A significant amount of CML was observed when bovine serum albumin was incubated with ribose for 7 days.	Ribose	86-92	albumin	Rattus norvegicus	53-66
18673269-6	2008	Finally, replacement of the ribose ring with a five member methanocarba ring constrained in the Northern conformation conferred dramatic increases in affinity to both P2Y(1) receptor antagonists as well as agonists.	Ribose	28-34	purinergic receptor P2Y1	Homo sapiens	167-182
18462755-0	2008	Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies.	Ribose	27-33	nudix hydrolase 5	Homo sapiens	54-59
18620531-4	2008	A number of NTP and inorganic pyrophosphate analogs were studied as substrates and/or inhibitors of NS3 NTPase activity, and it was found that the structure of nucleic base and ribose fragment of NTP molecule has a slight effect on its inhibitory (substrate) properties.	Ribose	177-183	inosine triphosphatase	Homo sapiens	104-110
18078995-6	2008	Interestingly, PARP is activated during T cell stimulation in the absence of DNA damage, leading to ADP-ribose polymers formation and transfer to nuclear acceptor proteins.	Ribose	104-110	poly(ADP-ribose) polymerase 1	Homo sapiens	15-19
18418069-4	2008	Given that Nudix domains are known to bind nucleoside diphosphate sugars and NAD, we predict that this domain in DBC1 and its homologs binds NAD metabolites such as ADP-ribose.	Ribose	169-175	cell cycle and apoptosis regulator 2	Homo sapiens	113-117
18172500-6	2008	We demonstrate interaction of poly(ADP-ribose) with this motif in two representative human proteins, APLF (aprataxin PNK-like factor) and CHFR (checkpoint protein with FHA and RING domains), and show that the actions of CHFR in the antephase checkpoint are abrogated by mutations in PBZ or by inhibition of poly(ADP-ribose) synthesis.	Ribose	39-45	aprataxin and PNKP like factor	Homo sapiens	101-105
18172500-6	2008	We demonstrate interaction of poly(ADP-ribose) with this motif in two representative human proteins, APLF (aprataxin PNK-like factor) and CHFR (checkpoint protein with FHA and RING domains), and show that the actions of CHFR in the antephase checkpoint are abrogated by mutations in PBZ or by inhibition of poly(ADP-ribose) synthesis.	Ribose	39-45	aprataxin and PNKP like factor	Homo sapiens	107-132
17716863-2	2008	These Epac-Selective Cyclic AMP Analogs (ESCAs) incorporate a 2"-O-methyl substitution on the ribose ring of cAMP, a modification that impairs their ability to activate protein kinase A (PKA), while leaving intact their ability to activate Epac (the Exchange Protein directly Activated by Cyclic AMP).	Ribose	94-100	Rap guanine nucleotide exchange factor 3	Homo sapiens	6-10
18232657-2	2008	We discovered that modification of natural and synthetic dinucleoside polyphosphates and nucleotides with lipophilic substituents on the ribose and base conferred P2Y12 receptor antagonist properties to these molecules producing potent inhibitors of ADP-mediated platelet aggregation.	Ribose	137-143	purinergic receptor P2Y12	Homo sapiens	163-168
17434215-0	2008	D-ribose improves cardiac contractility and hemodynamics, and reduces expression of c-fos in the hippocampus during sustained slow ventricular tachycardia in rats.	Ribose	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-89
17434215-14	2008	CONCLUSION: d-ribose improves hemodynamic parameters, cardiac contractility and prevents the activation of pro-apoptotic c-fos, demonstrating a neuroprotective effect of d-ribose during slow VT.	Ribose	12-20	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	121-126
17434215-14	2008	CONCLUSION: d-ribose improves hemodynamic parameters, cardiac contractility and prevents the activation of pro-apoptotic c-fos, demonstrating a neuroprotective effect of d-ribose during slow VT.	Ribose	170-178	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	121-126
17716863-2	2008	These Epac-Selective Cyclic AMP Analogs (ESCAs) incorporate a 2"-O-methyl substitution on the ribose ring of cAMP, a modification that impairs their ability to activate protein kinase A (PKA), while leaving intact their ability to activate Epac (the Exchange Protein directly Activated by Cyclic AMP).	Ribose	94-100	Rap guanine nucleotide exchange factor 3	Homo sapiens	240-244
17716863-2	2008	These Epac-Selective Cyclic AMP Analogs (ESCAs) incorporate a 2"-O-methyl substitution on the ribose ring of cAMP, a modification that impairs their ability to activate protein kinase A (PKA), while leaving intact their ability to activate Epac (the Exchange Protein directly Activated by Cyclic AMP).	Ribose	94-100	Rap guanine nucleotide exchange factor 3	Homo sapiens	250-299
17766683-1	2007	Poly(ADP-ribose)polymerases (PARP-1 and -2) are activated by DNA strand breaks to synthesize protein-bound ADP-ribose polymers from NAD+.	Ribose	9-15	poly (ADP-ribose) polymerase 1	Rattus norvegicus	29-42
17961220-2	2007	The main function of PARP-1 is to catalyze the transfer of ADP-ribose units from nicotinamide adenine dinucleotide (NAD+) to a large array of acceptor proteins, which comprises histones, transcription factors, as well as PARP-1 itself.	Ribose	63-69	poly (ADP-ribose) polymerase family, member 1	Mus musculus	21-27
17914811-7	2007	Guanosine 5"-diphosphate (5"-GDP), with a ribose moiety and a Re(I)-binding base, formed both possible diastereomers (RRe and SRe) of the fac-[Re(CO)3(H2O)({N7,Pbeta}GDP)]- macrochelate, with one slightly more abundant diastereomer suggested to be RRe by Mn2+ ion 1H NMR signal line-broadening combined with distances from molecular models.	Ribose	42-48	FA complementation group C	Homo sapiens	138-141
17961220-2	2007	The main function of PARP-1 is to catalyze the transfer of ADP-ribose units from nicotinamide adenine dinucleotide (NAD+) to a large array of acceptor proteins, which comprises histones, transcription factors, as well as PARP-1 itself.	Ribose	63-69	poly (ADP-ribose) polymerase family, member 1	Mus musculus	221-227
17407275-2	2007	We synthesized and characterized pharmacologically novel analogues of UDPG modified on the nucleobase, ribose, and glucose moieties, as the basis for designing novel ligands in conjunction with modeling.	Ribose	103-109	UDP-glucose pyrophosphorylase 2	Homo sapiens	70-74
17295209-2	2007	PARP activation was indicated by the appearance of polyADP-ribose, the incorporation of P32-labelled NADH, and by cellular NADH.	Ribose	58-65	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
17028139-1	2007	We have used electron paramagnetic probes attached to the ribose of ATP (SL-ATP) to monitor conformational changes in the nucleotide pocket of myosin.	Ribose	58-64	myosin heavy chain 14	Homo sapiens	143-149
17306228-7	2007	Furthermore, poly(epsilonADP-ribose) inhibited Parg activity to hydrolyse ribose-ribose bonds of poly(ADP-ribose).	Ribose	29-35	poly(ADP-ribose) glycohydrolase	Homo sapiens	47-51
17306228-7	2007	Furthermore, poly(epsilonADP-ribose) inhibited Parg activity to hydrolyse ribose-ribose bonds of poly(ADP-ribose).	Ribose	74-80	poly(ADP-ribose) glycohydrolase	Homo sapiens	47-51
17306228-8	2007	This study suggests the possibility that poly(epsilonADP-ribose) might be a useful tool for studying the poly(ADP-ribose) dynamics and function of Parg.	Ribose	56-63	poly(ADP-ribose) glycohydrolase	Homo sapiens	147-151
17267492-2	2007	The flaviviruses encode one methyltransferase, located at the N-terminal portion of the NS5 protein, to catalyze both guanine N-7 and ribose 2"-OH methylations during viral cap formation.	Ribose	134-140	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	88-91
17188026-3	2007	ADP-ribose polymers are rapidly catabolized into free ADP-ribose units by poly(ADP-ribose) glycohydrolase (PARG).	Ribose	4-10	poly(ADP-ribose) glycohydrolase	Homo sapiens	107-111
17706182-12	2007	Substitution of C-5 hydroxyl by fluorine in the ribose moiety greatly reduced interaction with hENT1/2 and hCNT1/2 and moderately reduced interaction with hCNT3 relative to thymidine and beta-AZR.	Ribose	48-54	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	95-102
17706182-12	2007	Substitution of C-5 hydroxyl by fluorine in the ribose moiety greatly reduced interaction with hENT1/2 and hCNT1/2 and moderately reduced interaction with hCNT3 relative to thymidine and beta-AZR.	Ribose	48-54	solute carrier family 28 member 1	Homo sapiens	107-114
17706182-12	2007	Substitution of C-5 hydroxyl by fluorine in the ribose moiety greatly reduced interaction with hENT1/2 and hCNT1/2 and moderately reduced interaction with hCNT3 relative to thymidine and beta-AZR.	Ribose	48-54	solute carrier family 28 member 3	Homo sapiens	155-160
17991682-5	2007	Long ADP-ribose chains (55-mer) promoted the formation of three specific complexes with p53.	Ribose	9-15	tumor protein p53	Homo sapiens	88-91
17427264-3	2007	A Maillard reaction mixture (25 mM D-ribose/L-lysine, 30 min at 120 degrees C) increased NF-kappaB translocation 18-fold (in PBS) or six-fold (in medium).	Ribose	35-43	nuclear factor kappa B subunit 1	Homo sapiens	89-98
17088057-4	2007	Compared to other P2Y receptors, the P2Y14 receptor has an atypical binding mode of the nucleobase, ribose, and phosphate moieties.	Ribose	100-106	purinergic receptor P2Y14	Homo sapiens	37-51
17111347-4	2006	We show that uridine and ribose, the two defining features of RNA, are both necessary and sufficient for TLR7 stimulation, and that short single-stranded RNA (ssRNA) act as TLR7 agonists in a sequence-independent manner as long as they contain several uridines in close proximity.	Ribose	25-31	toll like receptor 7	Homo sapiens	105-109
16931513-7	2006	Furthermore, we identified the site of ADP-ribose polymer attachment on ART2 as Arg-185, an arginine in a crucial loop of its catalytic core.	Ribose	43-49	ADP-ribosyltransferase 2b	Rattus norvegicus	72-76
17966099-7	2007	Therapy increased p53 expression and p53 phosphorylation at Ser392 and Ser20, and these changes correlated with poly-ADP-ribose levels and Ki-67 expression.	Ribose	121-127	tumor protein p53	Homo sapiens	18-21
17002451-1	2006	Inosine monophosphate (IMP) and its degradation products, ribose and hypoxanthine, are all considered to be important constituents in meat flavor formation and development.	Ribose	58-64	inositol monophosphatase 1	Homo sapiens	23-26
17002451-3	2006	During aging the concentration of IMP decreased with a simultaneous increase in the concentrations of inosine, hypoxanthine, and ribose.	Ribose	129-135	inositol monophosphatase 1	Homo sapiens	34-37
16969476-1	2006	The nonoxidative pentose phosphate pathway allows glucose conversion to ribose for DNA or RNA synthesis and glucose degradation to lactate controlled by transketolase enzyme reactions.	Ribose	72-78	transketolase	Homo sapiens	153-166
16931718-4	2006	eIF4AIII interacts with the phosphate-ribose backbone of six consecutive nucleotides and prevents part of the bound RNA from being double stranded.	Ribose	38-44	eukaryotic translation initiation factor 4A3	Homo sapiens	0-8
16942029-4	2006	Moreover, the trityl group at the 5"-position of the ribose seems to be crucial for TPase inhibition.	Ribose	53-59	thymidine phosphorylase	Homo sapiens	84-89
16912287-0	2006	West Nile virus 5"-cap structure is formed by sequential guanine N-7 and ribose 2"-O methylations by nonstructural protein 5.	Ribose	73-79	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	101-124
16582021-1	2006	Poly(ADP-ribose) polymerase-1 (PARP-1), the most abundant member of the PARP family, is a nuclear enzyme that catalyzes ADP-ribose transfer from NAD+ to specific acceptor proteins in response to DNA damage.	Ribose	9-15	poly (ADP-ribose) polymerase family, member 1	Mus musculus	31-37
16582021-1	2006	Poly(ADP-ribose) polymerase-1 (PARP-1), the most abundant member of the PARP family, is a nuclear enzyme that catalyzes ADP-ribose transfer from NAD+ to specific acceptor proteins in response to DNA damage.	Ribose	9-15	poly (ADP-ribose) polymerase family, member 1	Mus musculus	31-35
16912287-3	2006	Using West Nile virus (WNV), we demonstrate, for the first time, that the nonstructural protein 5 (NS5) mediates both guanine N-7 and ribose 2"-O methylations and therefore is essential for flavivirus 5"-cap formation.	Ribose	134-140	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	74-97
16912287-3	2006	Using West Nile virus (WNV), we demonstrate, for the first time, that the nonstructural protein 5 (NS5) mediates both guanine N-7 and ribose 2"-O methylations and therefore is essential for flavivirus 5"-cap formation.	Ribose	134-140	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	99-102
16686542-7	2006	Cocrystal structures of LuxS bound with two of the inhibitors largely confirmed the design principles, i.e., the importance of both the homocysteine and ribose moieties in high-affinity binding to the LuxS active site.	Ribose	153-159	Lutheran suppressor, X-linked	Homo sapiens	24-28
16526943-6	2006	In fact, PARG-silenced cells were more resistant than their wild-type counterparts to oxidant-induced apoptosis while exhibiting delayed PAR degradation and transient accumulation of ADP-ribose polymers longer than 15-mers at early stages of drug treatment.	Ribose	187-193	poly (ADP-ribose) glycohydrolase	Mus musculus	9-13
16686542-7	2006	Cocrystal structures of LuxS bound with two of the inhibitors largely confirmed the design principles, i.e., the importance of both the homocysteine and ribose moieties in high-affinity binding to the LuxS active site.	Ribose	153-159	Lutheran suppressor, X-linked	Homo sapiens	201-205
16605250-10	2006	A partial displacement of the active-site zinc in the FDH.ADP-ribose binary complex indicates that the disruption of the interaction between Glu-67 and Arg-368 is involved in the displacement of active-site zinc.	Ribose	62-68	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	54-57
16520376-5	2006	Using acetyl-lysine substrate analogs, we demonstrate that the Hst2 reaction proceeds via an initial SN2-type mechanism with the direct formation of an ADP-ribose-acetyl-lysine intermediate.	Ribose	156-162	histone deacetylase HST2	Saccharomyces cerevisiae S288C	63-67
16359641-0	2006	Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5"-triphosphate analogues at the human P2Y2 and P2Y4 receptors.	Ribose	54-60	purinergic receptor P2Y2	Homo sapiens	127-131
16380259-0	2006	Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket.	Ribose	129-135	complement C5	Homo sapiens	70-73
16892369-0	2006	Bisubstrate inhibitors of catechol O-methyltransferase (COMT): the crucial role of the ribose structural unit for inhibitor binding affinity.	Ribose	87-93	catechol-O-methyltransferase	Homo sapiens	26-54
16892369-0	2006	Bisubstrate inhibitors of catechol O-methyltransferase (COMT): the crucial role of the ribose structural unit for inhibitor binding affinity.	Ribose	87-93	catechol-O-methyltransferase	Homo sapiens	56-60
16892369-2	2006	A series of ribose-modified bisubstrate inhibitors of COMT featuring 2"-deoxy-, 3"-deoxy-, 2"-aminodeoxy-3"-deoxy-, and 2"-deoxy-3"-aminodeoxyribose-derived central moieties and analogues containing the carbocyclic skeleton of the natural product aristeromycin were synthesized and evaluated to investigate the molecular recognition properties of the ribose binding site in the enzyme.	Ribose	12-18	catechol-O-methyltransferase	Homo sapiens	54-58
16892369-6	2006	These results confirm that the ribose structural unit of the bisubstrate inhibitors of COMT is a key element of molecular recognition and that modifications thereof are delicate and may lead to surprises.	Ribose	31-37	catechol-O-methyltransferase	Homo sapiens	87-91
16359641-2	2006	UTP analogues with substitutions in the 2"-position of the ribose moiety retained capacity to activate both P2Y2 and P2Y4 receptors.	Ribose	59-65	purinergic receptor P2Y2	Homo sapiens	108-112
16685599-3	2006	TRPC3 and TRPC4 are activated by oxidants, which induce Na(+) and Ca(2+) entry into cells through mechanisms that are dependent on phospholipase C. TRPM2 is activated by oxidative stress or TNFalpha, and the mechanism involves production of ADP-ribose, which binds to an ADP-ribose binding cleft in the TRPM2 C-terminus.	Ribose	245-251	transient receptor potential cation channel subfamily C member 3	Homo sapiens	0-5
16143417-4	2006	Analysis of culture broth by thin layer chromatography confirmed that the disruption of tkt allowed B. subtilis JY200 to produce d-ribose.	Ribose	129-137	transketolase	Bacillus subtilis subsp. subtilis str. 168	88-91
16388603-4	2006	In this study, Sir2-catalyzed reactions are shown to transfer an 18O label from the peptide acetyl group to the ribose 1"-position of OAADPr, providing direct evidence for the formation of a covalent alpha-1"-O-alkylamidate, whose existence is further supported by the observed methanolysis of the alpha-1"-O-alkylamidate intermediate to yield beta-1"-O-methyl-ADP-ribose in a Sir2 histidine-to-alanine mutant.	Ribose	112-118	sirtuin 1	Homo sapiens	15-19
16388603-4	2006	In this study, Sir2-catalyzed reactions are shown to transfer an 18O label from the peptide acetyl group to the ribose 1"-position of OAADPr, providing direct evidence for the formation of a covalent alpha-1"-O-alkylamidate, whose existence is further supported by the observed methanolysis of the alpha-1"-O-alkylamidate intermediate to yield beta-1"-O-methyl-ADP-ribose in a Sir2 histidine-to-alanine mutant.	Ribose	112-118	sirtuin 1	Homo sapiens	377-381
16086668-1	2006	In vitro incubation of bovine Cu,Zn-SOD (Cu,Zn-superoxide dismutase) with glucose, ribose or fructose results in a remarkable inactivation of the enzyme.	Ribose	83-89	superoxide dismutase [Cu-Zn]	Bos taurus	30-39
16086668-1	2006	In vitro incubation of bovine Cu,Zn-SOD (Cu,Zn-superoxide dismutase) with glucose, ribose or fructose results in a remarkable inactivation of the enzyme.	Ribose	83-89	superoxide dismutase [Cu-Zn]	Bos taurus	41-67
16278211-2	2006	Mammalian cells contain mono-ADP-ribosyltransferases that catalyze the formation of ADP-ribose-(arginine) protein, which can be cleaved by a 39-kDa ADP-ribose-(arginine) protein hydrolase (ARH1), resulting in release of free ADP-ribose and regeneration of unmodified protein.	Ribose	88-94	ADP-ribosylarginine hydrolase	Homo sapiens	189-193
16278211-5	2006	We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds.	Ribose	75-81	ADP-ribosylarginine hydrolase	Homo sapiens	40-44
16278211-5	2006	We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds.	Ribose	75-81	ADP-ribosylserine hydrolase	Homo sapiens	96-100
16278211-5	2006	We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds.	Ribose	75-81	poly(ADP-ribose) glycohydrolase	Homo sapiens	118-122
16219773-2	2006	Using Drosophila genetic tools, we characterize the expression and function of poly(ADP-ribose) glycohydrolase (PARG), the primary enzyme responsible for degrading protein-bound ADP-ribose moieties.	Ribose	88-94	Poly(ADP-ribose) glycohydrolase	Drosophila melanogaster	112-116
16219773-3	2006	Strongly increasing or decreasing PARG levels mimics the effects of Parp mutation, supporting PARG"s postulated roles in vivo both in removing ADP-ribose adducts and in facilitating multiple activity cycles by individual PARP molecules.	Ribose	147-153	Poly(ADP-ribose) glycohydrolase	Drosophila melanogaster	34-38
16219773-3	2006	Strongly increasing or decreasing PARG levels mimics the effects of Parp mutation, supporting PARG"s postulated roles in vivo both in removing ADP-ribose adducts and in facilitating multiple activity cycles by individual PARP molecules.	Ribose	147-153	Poly-(ADP-ribose) polymerase	Drosophila melanogaster	68-72
16219773-3	2006	Strongly increasing or decreasing PARG levels mimics the effects of Parp mutation, supporting PARG"s postulated roles in vivo both in removing ADP-ribose adducts and in facilitating multiple activity cycles by individual PARP molecules.	Ribose	147-153	Poly(ADP-ribose) glycohydrolase	Drosophila melanogaster	94-98
16685599-3	2006	TRPC3 and TRPC4 are activated by oxidants, which induce Na(+) and Ca(2+) entry into cells through mechanisms that are dependent on phospholipase C. TRPM2 is activated by oxidative stress or TNFalpha, and the mechanism involves production of ADP-ribose, which binds to an ADP-ribose binding cleft in the TRPM2 C-terminus.	Ribose	245-251	transient receptor potential cation channel subfamily C member 4	Homo sapiens	10-15
16685599-3	2006	TRPC3 and TRPC4 are activated by oxidants, which induce Na(+) and Ca(2+) entry into cells through mechanisms that are dependent on phospholipase C. TRPM2 is activated by oxidative stress or TNFalpha, and the mechanism involves production of ADP-ribose, which binds to an ADP-ribose binding cleft in the TRPM2 C-terminus.	Ribose	245-251	transient receptor potential cation channel subfamily M member 2	Homo sapiens	148-153
16685599-3	2006	TRPC3 and TRPC4 are activated by oxidants, which induce Na(+) and Ca(2+) entry into cells through mechanisms that are dependent on phospholipase C. TRPM2 is activated by oxidative stress or TNFalpha, and the mechanism involves production of ADP-ribose, which binds to an ADP-ribose binding cleft in the TRPM2 C-terminus.	Ribose	245-251	tumor necrosis factor	Homo sapiens	190-198
16685599-3	2006	TRPC3 and TRPC4 are activated by oxidants, which induce Na(+) and Ca(2+) entry into cells through mechanisms that are dependent on phospholipase C. TRPM2 is activated by oxidative stress or TNFalpha, and the mechanism involves production of ADP-ribose, which binds to an ADP-ribose binding cleft in the TRPM2 C-terminus.	Ribose	245-251	transient receptor potential cation channel subfamily M member 2	Homo sapiens	303-308
16151053-6	2005	Hyperoxia induced PARP activity in both cell types, as revealed by poly-ADP-ribose accumulation.	Ribose	76-82	poly (ADP-ribose) polymerase family, member 1	Mus musculus	18-22
16366591-1	2005	Combining molecular dynamics (MD) in a hydrated phospholipid (DOPC) bilayer, a Monte Carlo search, and synthesis of locked nucleotide analogues, we discovered that the Southern conformation of the ribose is preferred for ligand recognition by the P2Y(6) receptor.	Ribose	197-203	pyrimidinergic receptor P2Y6	Homo sapiens	247-262
16686439-6	2006	Consistent with these observations Ca2+ imaging, tension recording and electrophysiology demonstrated that AMPK, like hypoxia, activates each cell type via discrete Ca2+ signalling mechanisms: cyclic ADP-ribose-dependent Ca2+ mobilization from the sarcoplasmic reticulum via ryanodine receptors in pulmonary arterial smooth muscle cells and voltage-gated Ca2+ influx into carotid body glomus cells.	Ribose	204-210	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	107-111
16229490-2	2005	Spin-labeled ATP (SL-ATP) with the spin label attached to the ribose, was observed to be an excellent substrate analogue for P-gp.	Ribose	62-68	phosphoglycolate phosphatase	Homo sapiens	125-129
16262266-1	2005	In response to DNA strand breaks in the genome of higher eukaryotes, poly(ADP-ribose)polymerase 1 (PARP-1) catalyses the covalent attachment of ADP-ribose units from NAD(+) to various nuclear acceptor proteins including PARP-1 itself.	Ribose	78-84	poly(ADP-ribose) polymerase 1	Homo sapiens	99-105
16262266-1	2005	In response to DNA strand breaks in the genome of higher eukaryotes, poly(ADP-ribose)polymerase 1 (PARP-1) catalyses the covalent attachment of ADP-ribose units from NAD(+) to various nuclear acceptor proteins including PARP-1 itself.	Ribose	78-84	poly(ADP-ribose) polymerase 1	Homo sapiens	220-226
16144699-4	2005	However, the biogenesis of plant miRNAs consists of an additional step, i.e., the miRNAs are methylated on the ribose of the last nucleotide by the miRNA methyltransferase HEN1.	Ribose	111-117	double-stranded RNA binding protein-related / DsRBD protein-like protein	Arabidopsis thaliana	172-176
16157349-1	2005	The ribose-binding protein (RBP) is a sugar-binding bacterial periplasmic protein whose function is associated with a large allosteric conformational change from an open to a closed conformation upon binding to ribose.	Ribose	4-10	retinol binding protein 4	Homo sapiens	28-31
16229490-8	2005	The corresponding ESR spectra of wild-type and Cys-less P-gp in the presence of SL-ATP indicate that a cysteine side chain of P-gp is located close to the ribose of the bound nucleotide.	Ribose	155-161	phosphoglycolate phosphatase	Homo sapiens	56-60
16076193-1	2005	The factors controlling the highly alpha-selective C-glycosylation of ribose derivatives were determined by examining the stereoselective reactions of 18 ribose analogues differing in substitution at C-2, C-3, and C-4.	Ribose	70-76	complement C2	Homo sapiens	200-208
16229490-8	2005	The corresponding ESR spectra of wild-type and Cys-less P-gp in the presence of SL-ATP indicate that a cysteine side chain of P-gp is located close to the ribose of the bound nucleotide.	Ribose	155-161	phosphoglycolate phosphatase	Homo sapiens	126-130
16086588-4	2005	The ability of GFPP to form nucleotide-sugars from a series of base-, ribose-, phosphate-, and hexose-modified precursor molecules has revealed that the enzyme active site senses a series of substrate substituents that drive substrate/nonsubstrate discrimination.	Ribose	70-76	fucose-1-phosphate guanylyltransferase	Homo sapiens	15-19
16076193-1	2005	The factors controlling the highly alpha-selective C-glycosylation of ribose derivatives were determined by examining the stereoselective reactions of 18 ribose analogues differing in substitution at C-2, C-3, and C-4.	Ribose	70-76	complement C4A (Rodgers blood group)	Homo sapiens	214-217
15840508-5	2005	In this article, we describe the use of the ribose-conjugated fluorescent guanine nucleotide analog BODIPYFL-GTP as a spectroscopic probe to measure intrinsic and RGS protein-catalyzed nucleotide hydrolysis by Galphao.	Ribose	44-50	paired like homeodomain 2	Homo sapiens	163-166
16212545-7	2005	It can be assumed that the hydroxyl group of PCVTP mimics the 3"-hydroxyl group of the ribose residue and plays an important role in the interaction with TdT.	Ribose	87-93	DNA nucleotidylexotransferase	Homo sapiens	154-157
16091044-9	2005	The results show that Cfr is an RNA methyltransferase that targets nucleotide A2503 and inhibits ribose methylation at nucleotide C2498, thereby causing resistance to chloramphenicol, florfenicol and clindamycin.	Ribose	97-103	florfenicol/chloramphenicol resistance protein	Escherichia coli	22-25
16083012-2	2005	New mammalian snoRNA U87 belongs to the C/D family and is involved in ribose methylation of guanylic acid residue (position 3468) in 28S rRNA.	Ribose	70-76	small nucleolar RNA, C/D box 15A	Homo sapiens	14-20
15840508-5	2005	In this article, we describe the use of the ribose-conjugated fluorescent guanine nucleotide analog BODIPYFL-GTP as a spectroscopic probe to measure intrinsic and RGS protein-catalyzed nucleotide hydrolysis by Galphao.	Ribose	44-50	G protein subunit alpha o1	Homo sapiens	210-217
16852085-9	2005	The ribose favors the syn orientation significantly more than the deoxyribose.	Ribose	4-10	synemin	Homo sapiens	22-25
15790498-2	2005	Binding of its C-terminal region to glycosphingolipid Gb3 and Gb4 receptors on cell membrane is necessary for incorporation into cells, while the N-terminal polypeptide catalyzes transfer of the ADP-ribose moiety of NAD at N2 of dG in DNA.	Ribose	199-205	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	54-57
15850388-4	2005	Relatively few substitutions are needed to convert either DNA analogue of TAR into a high-affinity binder, with the ribose requirements being restricted largely to regions that directly contact the ligand.	Ribose	116-122	RNA binding motif protein 8A	Homo sapiens	74-77
15381153-11	2005	The results thus provide evidence that endogenous ADP-ribosylation of eEF2 can also take place by the binding of free ADP-ribose.	Ribose	122-128	eukaryotic translation elongation factor 2	Homo sapiens	70-74
15652820-1	2005	Non-enzymatic posttranslational modifications of bovine serum albumin (BSA) by oxo-compounds, particularly glucose, ribose, glyoxal and glutardialdehyde, have been investigated using a set of modern chromatographic and electrophoretic separation methods.	Ribose	116-122	albumin	Homo sapiens	56-69
15548765-6	2005	PARP-1 inhibition blocked ADP-ribose polymer formation, preserved mitochondrial membrane integrity, and counteracted the reduction of NF-kappaB activity, thus preventing the appearance of necrosis.	Ribose	30-36	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
15684411-7	2005	Furthermore, Poa1p is strongly inhibited by ADP-ribose (K(I), 17 microM), modestly inhibited by other nucleotides containing an ADP-ribose moiety and not inhibited at all by other tested molecules.	Ribose	48-54	ADP-ribose 1''-phosphate phosphatase	Saccharomyces cerevisiae S288C	13-18
15651784-2	2005	Among potent and selective A3 AR agonists are novel methanocarba adenosine analogues in which the conformation of a pseudo-ribose moiety is locked in the North (N) hemisphere of the pseudorotational cycle.	Ribose	123-129	adenosine A3 receptor	Homo sapiens	27-32
15561722-3	2005	Here we show through structure-guided mutagenesis that TRPM2 gating by ADP-ribose and both oxidative and nitrosative stresses requires an intact ADP-ribose binding cleft in the C-terminal nudix domain.	Ribose	75-81	transient receptor potential cation channel subfamily M member 2	Homo sapiens	55-60
15561722-3	2005	Here we show through structure-guided mutagenesis that TRPM2 gating by ADP-ribose and both oxidative and nitrosative stresses requires an intact ADP-ribose binding cleft in the C-terminal nudix domain.	Ribose	149-155	transient receptor potential cation channel subfamily M member 2	Homo sapiens	55-60
17150753-1	2005	Transfer RNA (Gm18) methyltransferase (TrmH, EC 2.1.1.34) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the 2"-OH of the ribose of guanosine at position 18 in the D-loop of tRNA.	Ribose	157-163	mitochondrially encoded tRNA glycine	Homo sapiens	209-213
15598803-5	2005	Unexpectedly, however, AtPLT5 catalyzes also the transport of the cyclic polyol myo-inositol and of different hexoses and pentoses, including ribose, a sugar that is not transported by any of the previously characterized plant sugar transporters.	Ribose	142-148	AINTEGUMENTA-like 5	Arabidopsis thaliana	23-29
15347676-0	2004	Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2.	Ribose	45-51	nudix hydrolase 9	Homo sapiens	13-18
15347676-0	2004	Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2.	Ribose	45-51	transient receptor potential cation channel subfamily M member 2	Homo sapiens	85-90
15465278-3	2004	Upon activation PARP-1 uses NAD(+) as a substrate to catalyze the transfer of ADP-ribose subunits to a host of nuclear proteins.	Ribose	82-88	poly (ADP-ribose) polymerase 1	Rattus norvegicus	16-22
15527770-5	2004	However, ISG20 also has distinctive residues, Met14 and Arg53, to accommodate hydrogen bonds with the 2"-OH group of the UMP ribose, and these residues may be responsible for the preference of ISG20 for RNA substrates.	Ribose	125-131	interferon stimulated exonuclease gene 20	Homo sapiens	9-14
15527770-5	2004	However, ISG20 also has distinctive residues, Met14 and Arg53, to accommodate hydrogen bonds with the 2"-OH group of the UMP ribose, and these residues may be responsible for the preference of ISG20 for RNA substrates.	Ribose	125-131	interferon stimulated exonuclease gene 20	Homo sapiens	193-198
15465340-1	2004	The ribose moiety of adenine nucleotide 3",5"-bisphosphate antagonists of the P2Y(1) receptor has been successfully substituted with a rigid methanocarba ring system, leading to the conclusion that the North (N) ring conformation is preferred in receptor binding.	Ribose	4-10	purinergic receptor P2Y1	Homo sapiens	78-93
15450491-3	2004	Recent research has shown that LuxS uses Fe(2+) to catalyze an internal redox reaction, shifting the ribose carbonyl group from its C1 to C3 position.	Ribose	101-107	Lutheran suppressor, X-linked	Homo sapiens	31-35
15549272-3	2004	Here we demonstrate, using patch clamp electrophysiology, that the antifungal imidazoles clotrimazole and econazole inhibit ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2 (hTRPM2).	Ribose	128-134	transient receptor potential cation channel subfamily M member 2	Homo sapiens	200-205
15549272-3	2004	Here we demonstrate, using patch clamp electrophysiology, that the antifungal imidazoles clotrimazole and econazole inhibit ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2 (hTRPM2).	Ribose	128-134	transient receptor potential cation channel subfamily M member 2	Homo sapiens	207-213
15245332-7	2004	On the other hand, Lys-435 and/or Lys-436 are implicated in the coenzyme specificity (NADP(+) versus NAD(+)) of maize NADP(+)-ME by interacting with the 2"-phosphate group of the ribose ring.	Ribose	179-185	NADP-dependent malic enzyme	Zea mays	118-128
16305531-6	2005	Key structural features determining A3AR interaction include the N6-benzyl group, 2-position substitution such as halo, substitution of ribose (e.g., the (N)-methanocarba ring system, various 2"- and 3"-substitutions and 4"-thio substitution of oxygen).	Ribose	136-142	adenosine A3 receptor	Homo sapiens	36-40
16305531-7	2005	Conformational studies of the ribose moiety and its equivalents indicate that the ring oxygen is not required and the North (N) ring conformation is preferred in binding to the A3AR.	Ribose	30-36	adenosine A3 receptor	Homo sapiens	177-181
15450800-1	2004	The enzyme poly(ADP-ribose) glycohydrolase (PARG) catalyzes the hydrolysis of glycosidic bonds of ADP-ribose polymers, producing monomeric ADP-ribose units.	Ribose	20-26	poly(ADP-ribose) glycohydrolase	Homo sapiens	44-48
15450800-1	2004	The enzyme poly(ADP-ribose) glycohydrolase (PARG) catalyzes the hydrolysis of glycosidic bonds of ADP-ribose polymers, producing monomeric ADP-ribose units.	Ribose	102-108	poly(ADP-ribose) glycohydrolase	Homo sapiens	11-42
15450800-1	2004	The enzyme poly(ADP-ribose) glycohydrolase (PARG) catalyzes the hydrolysis of glycosidic bonds of ADP-ribose polymers, producing monomeric ADP-ribose units.	Ribose	102-108	poly(ADP-ribose) glycohydrolase	Homo sapiens	44-48
15450800-6	2004	This article describes a method whereby the ADP-ribose product of the PARG-catalyzed reaction is converted into a fluorescent dye.	Ribose	48-54	poly(ADP-ribose) glycohydrolase	Homo sapiens	70-74
15145932-5	2004	Pentoses, such as arabinose, ribose, and deoxyribose, inhibit the interaction between SP-D and mannan, one of the well-studied hexose ligands for SP-D, and biologically relevant d-forms of the pentoses are better competitors than the l-forms.	Ribose	29-35	surfactant associated protein D	Mus musculus	86-90
15296642-2	2004	Identification of inhibitors specifically targeting TK and preventing the nonoxidative PPP from generating the RNA ribose precursor, ribose-5-phosphate, provides a novel approach for developing effective anticancer therapeutic agents.	Ribose	115-121	transketolase	Homo sapiens	52-54
15145932-5	2004	Pentoses, such as arabinose, ribose, and deoxyribose, inhibit the interaction between SP-D and mannan, one of the well-studied hexose ligands for SP-D, and biologically relevant d-forms of the pentoses are better competitors than the l-forms.	Ribose	29-35	surfactant associated protein D	Mus musculus	146-150
33873776-5	2004	A second group of proteins unrelated to those above, the sirtuins (Sir2) and poly ADP-ribose polymerases (PARPs), cleave NAD and transfer the ADP-ribose group to acetyl groups and proteins, respectively.	Ribose	86-92	sirtuin 1	Homo sapiens	67-71
15060078-1	2004	By exploiting nuclear magnetic resonance (NMR) techniques along with novel applications of saturation difference analysis, we deciphered the functions of the previously uncharacterized products of three bacterial genes, rbsD, fucU, and yiiL, which are part of the ribose, fucose, and rhamnose operons of Escherichia coli, respectively.	Ribose	264-270	fucose mutarotase	Homo sapiens	226-230
15146171-3	2004	Using a series of modified substrates to explore the unwinding mechanism of NPH-II, we observed that the helicase tracks exclusively on the loading strand, where it requires covalent continuity and specifically recognizes the ribose-phosphate backbone.	Ribose	226-232	helicase for meiosis 1	Homo sapiens	105-113
15122881-7	2004	Comparisons of the MTAP and MTAN inhibitor complexes reveal size and electrostatic potential differences in the purine, ribose, and 5"-alkylthio binding sites, which account for the substrate specificity and reactions catalyzed.	Ribose	120-126	methylthioadenosine phosphorylase	Homo sapiens	19-23
15287744-2	2004	The proposed mechanism involves a series of proton-transfer reactions, which are catalyzed by an Fe2+ ion and two general acids/bases in the LuxS active site, resulting in the migration of the ribose carbonyl group from its C1 to C3 position.	Ribose	193-199	Lutheran suppressor, X-linked	Homo sapiens	141-145
15104242-2	2004	Here, we have probed this phenomenon with respect to the ribose moiety using a series of ribose-modified adenosine derivatives, examining binding affinity and activation of the human A3 AR expressed in CHO cells.	Ribose	57-63	adenosine A3 receptor	Homo sapiens	183-188
15207836-3	2004	Assays were performed in purified brain cell nuclei to determine Parp activity by incorporation of radiolabeled ADP-ribose moieties from nicotinamide adenine dinucleotide (NAD+) into nuclear proteins.	Ribose	116-122	poly (ADP-ribose) polymerase 1	Rattus norvegicus	65-69
15104242-3	2004	Both 2"- and 3"-hydroxyl groups in the ribose moiety contribute to A3 AR binding and activation, with 2"-OH being more essential.	Ribose	39-45	adenosine A3 receptor	Homo sapiens	67-72
18228447-1	2004	Poly(ADP-ribosyl)ation is a post-translational modification catalyzed mostly by the 116-kDa enzyme poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme that transfers an ADP-ribose moiety onto a limited number of nuclear proteins, including itself.	Ribose	108-114	poly(ADP-ribose) polymerase 1	Homo sapiens	130-136
14685157-5	2004	The hydrolysis of poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase (PARG) was also required, since specific PARG inhibitors, which limit the production of ADP-ribose molecules, restored the function of ABC transporters.	Ribose	27-33	poly(ADP-ribose) glycohydrolase	Homo sapiens	38-69
14685157-5	2004	The hydrolysis of poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase (PARG) was also required, since specific PARG inhibitors, which limit the production of ADP-ribose molecules, restored the function of ABC transporters.	Ribose	27-33	poly(ADP-ribose) glycohydrolase	Homo sapiens	71-75
14685157-5	2004	The hydrolysis of poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase (PARG) was also required, since specific PARG inhibitors, which limit the production of ADP-ribose molecules, restored the function of ABC transporters.	Ribose	27-33	poly(ADP-ribose) glycohydrolase	Homo sapiens	111-115
14987257-4	2004	PARP-1 attaches most ADP-ribose residues onto itself, leading to downregulation of enzyme activity.	Ribose	25-31	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
14987257-9	2004	Therefore, PARG is likely to contribute to maintaining the active state of PARP-1 by continuously removing inhibitory ADP-ribose residues from PARP-1.	Ribose	122-128	poly(ADP-ribose) glycohydrolase	Homo sapiens	11-15
14987257-9	2004	Therefore, PARG is likely to contribute to maintaining the active state of PARP-1 by continuously removing inhibitory ADP-ribose residues from PARP-1.	Ribose	122-128	poly(ADP-ribose) polymerase 1	Homo sapiens	75-81
14757696-4	2004	Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, generates NADPH in a reaction linked to the de novo production of ribose.	Ribose	167-173	glucose-6-phosphate dehydrogenase 2	Mus musculus	35-39
14749375-7	2004	In addition, our data show that PARP activity regulates the DNA binding activity of TRF2 via both a covalent heteromodification of the dimerization domain of TRF2 and a noncovalent binding of poly(ADP-ribose) to the myb domain of TRF2.	Ribose	201-207	poly(ADP-ribose) polymerase 1	Homo sapiens	32-36
14749375-7	2004	In addition, our data show that PARP activity regulates the DNA binding activity of TRF2 via both a covalent heteromodification of the dimerization domain of TRF2 and a noncovalent binding of poly(ADP-ribose) to the myb domain of TRF2.	Ribose	201-207	telomeric repeat binding factor 2	Homo sapiens	84-88
15078216-2	2004	A number of structural determinants for A(3)AR activation have recently been identified, including the N(6)-benzyl group, methanocarba substitution of ribose, 2-chloro and 2-fluoro substituents, various 2"- and 3"-substitutions and 4"-thio substitution of oxygen.	Ribose	151-157	adenosine A3 receptor	Homo sapiens	40-46
14654047-7	2004	Ribose-AGEs bound RAGE with high affinity within 1 week of incubation in contrast to glucose- and fructose-AGE, which required 12 and 6 weeks, respectively, to generate equivalent RAGE ligands (IC50=0.66, 0.93, and 1.7 microM, respectively).	Ribose	0-6	advanced glycosylation end-product specific receptor	Homo sapiens	18-22
14654047-7	2004	Ribose-AGEs bound RAGE with high affinity within 1 week of incubation in contrast to glucose- and fructose-AGE, which required 12 and 6 weeks, respectively, to generate equivalent RAGE ligands (IC50=0.66, 0.93, and 1.7 microM, respectively).	Ribose	0-6	advanced glycosylation end-product specific receptor	Homo sapiens	180-184
14994994-1	2004	DNA damage-activated homodimer of PARP-1 binds to single-strand breaks and catalyzes the synthesis and transfer of negatively charged ADP-ribose polymers to nuclear protein acceptors, including itself.	Ribose	138-144	poly (ADP-ribose) polymerase 1	Rattus norvegicus	34-40
14522996-1	2003	Silent information regulator 2 (Sir2) enzymes catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose.	Ribose	186-192	sirtuin 2	Homo sapiens	0-30
14522996-1	2003	Silent information regulator 2 (Sir2) enzymes catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose.	Ribose	186-192	sirtuin 2	Homo sapiens	32-36
14522996-11	2003	The observed enzyme-catalyzed formation of a labile 1"-acetylated-ADP-fluororibose intermediate using beta-2"-deoxy-2"-fluororibo-NAD+ supports a mechanism where, after nicotinamide-ribosyl cleavage, the carbonyl oxygen of acetylated substrate attacks the C-1" ribose to form an initial iminium adduct.	Ribose	259-267	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	102-108
14633848-7	2003	In a more systematic screening for potential substrates for FN3K-RP, we found, however, that both enzymes phosphorylated ketosamines with a D-configuration in C3 (psicoselysine, 1-deoxy-1-morpholino-psicose, 1-deoxy-1-morpholino-ribulose, lysozyme glycated with allose-the C3 epimer of glucose, or with ribose).	Ribose	303-309	fructosamine 3 kinase related protein	Homo sapiens	60-67
12893755-4	2003	RNA ribose isolated from TRMA fibroblasts in thiamine-depleted cultures shows a time-dependent decrease in the fraction of ribose derived via transketolase, a thiamine-dependent enzyme in the pentose cycle.	Ribose	4-10	transketolase	Homo sapiens	142-155
14594650-2	2003	PARP mediates the transfer of poly-ADP-ribose moieties on itself and other nuclear proteins by the breakdown of NAD+.	Ribose	39-45	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
14584948-1	2003	Preference for the northern (N) ring conformation of the ribose moiety of adenine nucleotide 3",5"-bisphosphate antagonists of P2Y(1) receptors was established by using a ring-constrained methanocarba (a bicyclo[3.1.0]hexane) ring as a ribose substitute (Nandanan et al.	Ribose	57-63	purinergic receptor P2Y1	Homo sapiens	127-133
14584948-1	2003	Preference for the northern (N) ring conformation of the ribose moiety of adenine nucleotide 3",5"-bisphosphate antagonists of P2Y(1) receptors was established by using a ring-constrained methanocarba (a bicyclo[3.1.0]hexane) ring as a ribose substitute (Nandanan et al.	Ribose	236-242	purinergic receptor P2Y1	Homo sapiens	127-133
14527731-3	2003	At present, only a single enzyme, poly (ADP-ribose) glycohydrolase (PARG), has been identified to catalyze ADP-ribose polymer hydrolysis in the cell causing a rapid turnover of the biopolymer which may ultimately result in lethal depletion of cellular NAD(+) pools.	Ribose	44-50	poly(ADP-ribose) glycohydrolase	Homo sapiens	68-72
12819211-6	2003	Analogs modified in the 2"-position of the ribose induced stronger Epac1 activation than cAMP but were only partial agonists for cAPK.	Ribose	43-49	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	67-72
12897160-6	2003	In further studies, we have shown that DNA ligase III also binds directly to poly(ADP-ribose) and preferentially associates with poly(ADP-ribosyl)ated PARP-1 in vitro and in vivo.	Ribose	86-92	DNA ligase 3	Homo sapiens	39-53
14529360-8	2003	As PARP-1 is now recognised as playing a role also in the regulation of gene transcription, this further increases the intricacy of poly(ADP-ribosyl)ation in the control of cell homeostasis and challenges the notion that energy collapse is the sole mechanism by which poly(ADP-ribose) formation contributes to cell death.	Ribose	277-284	poly(ADP-ribose) polymerase 1	Homo sapiens	3-9
14512733-3	2003	In the other case, the CSA tensor is located on the nucleotide base whereas the dipolar interaction is located on the adjoining ribose unit.	Ribose	128-134	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	23-26
12890775-6	2003	Tat seems to cause mobilization of Ca2+ from ryanodine-sensitive internal stores because its effect was prevented by both 8-bromo-cyclic adenosine diphosphate-ribose and dantrolene.	Ribose	159-165	tyrosine aminotransferase	Homo sapiens	0-3
12829617-5	2003	Glucose-6-phosphate dehydrogenase (G6PD) functions as the first and rate-limiting enzyme in the pentose phosphate pathway, responsible for the generation of NADPH in a reaction coupled to the de novo production of cellular ribose.	Ribose	223-229	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-33
12829617-5	2003	Glucose-6-phosphate dehydrogenase (G6PD) functions as the first and rate-limiting enzyme in the pentose phosphate pathway, responsible for the generation of NADPH in a reaction coupled to the de novo production of cellular ribose.	Ribose	223-229	glucose-6-phosphate dehydrogenase 2	Mus musculus	35-39
12788371-8	2003	Our results show that the ribose moiety and the dipole moment vector could be factors that make possible the modulation of the RyR activity by adenosine and its metabolites.	Ribose	26-32	ryanodine receptor 1	Homo sapiens	127-130
12893280-7	2003	This indicates that the closed ribose ring is important for binding of nucleoside drugs to hCNT2.	Ribose	31-37	solute carrier family 28 member 2	Homo sapiens	91-96
12606624-1	2003	Excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme catalyzing the transfer of ADP-ribose units from NAD to acceptor proteins, induces cellular energy failure by NAD and ATP depletion and has been proposed to play a causative role in a number of pathological conditions, including ischemia/reperfusion injury.	Ribose	33-39	poly (ADP-ribose) polymerase family, member 1	Mus musculus	55-61
12794088-7	2003	These findings along with molecular modeling and three-dimensional structure comparison of the GlcAT-I catalytic center with that of the Bacillus subtilis glycosyltransferase SpsA provided evidence that the interactions of Asp195 with the ribose moiety of UDP and of Asp196 with the metal cation Mn2+ were crucial for GlcAT-I function.	Ribose	239-245	beta-1,3-glucuronyltransferase 3	Homo sapiens	95-102
12794088-7	2003	These findings along with molecular modeling and three-dimensional structure comparison of the GlcAT-I catalytic center with that of the Bacillus subtilis glycosyltransferase SpsA provided evidence that the interactions of Asp195 with the ribose moiety of UDP and of Asp196 with the metal cation Mn2+ were crucial for GlcAT-I function.	Ribose	239-245	beta-1,3-glucuronyltransferase 3	Homo sapiens	318-325
12853316-2	2003	Upon activation, the enzyme hydrolyzes NAD(+) to nicotinamide and transfers ADP ribose units to a variety of nuclear proteins, including histones and PARP-1 itself.	Ribose	80-86	poly(ADP-ribose) polymerase 1	Homo sapiens	150-156
12770927-12	2003	Furthermore, reducing sugars have been shown to induce oxidative stress, and ribose could be a possible cause for the upregulation of HO-1, which has been implicated in the release of angiogenic factors.	Ribose	77-83	heme oxygenase 1	Homo sapiens	134-138
12765698-4	2003	Thus, stimulation of TRPM2 is likely to occur after activation of CD38 (producing ADP-ribose) and during the oxidative burst (enhancing the NAD concentration).	Ribose	86-92	transient receptor potential cation channel subfamily M member 2	Homo sapiens	21-26
12765698-4	2003	Thus, stimulation of TRPM2 is likely to occur after activation of CD38 (producing ADP-ribose) and during the oxidative burst (enhancing the NAD concentration).	Ribose	86-92	CD38 molecule	Homo sapiens	66-70
12705835-9	2003	These data suggest a catalytic mechanism in which the metal ion catalyzes an intramolecular redox reaction, shifting the carbonyl group from the C-1 position to the C-3 position of the ribose.	Ribose	185-191	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	145-148
12705835-9	2003	These data suggest a catalytic mechanism in which the metal ion catalyzes an intramolecular redox reaction, shifting the carbonyl group from the C-1 position to the C-3 position of the ribose.	Ribose	185-191	complement C3	Homo sapiens	165-168
12676457-6	2003	Activated PARP-1 cleaves NAD(+) into nicotinamide and ADP-ribose and polymerizes the latter on nuclear acceptor proteins.	Ribose	58-64	poly(ADP-ribose) polymerase 1	Homo sapiens	10-16
12788450-8	2003	Syn-conformers of dU are stabilized by the intramolecular hydrogen bond O5"H...O2 and the dominant conformation of the ribose ring is C2"-endo.	Ribose	119-125	synemin	Homo sapiens	0-3
12628750-1	2003	Poly(ADP-ribose) polymerases (PARPs) are a group of protein-modifying and nucleotide-polymerizing enzymes able to catalyze the transfer of multiple ADP-ribose units from NAD to substrate proteins.	Ribose	9-15	poly (ADP-ribose) polymerase family, member 1	Mus musculus	30-35
12514117-0	2003	CD38/cyclic ADP-ribose-mediated Ca2+ signaling contributes to airway smooth muscle hyper-responsiveness.	Ribose	16-22	CD38 molecule	Homo sapiens	0-4
12370179-9	2002	The inability of OAADPr to inhibit the reaction of NUDT9 with ADP-ribose suggests that NUDT9 binds OAADPr with low affinity, likely due to steric considerations of the additional acetylated-ribose moiety.	Ribose	66-72	nudix hydrolase 9	Homo sapiens	51-56
12524316-1	2003	Ribose-modified highly-fluorescent sulfoindocyanine ATP and ADP analogs, 2"(3")-O-Cy3-EDA-AT(D)P, with kinetics similar to AT(D)P, enable myosin and actomyosin ATPase enzymology with single substrate molecules.	Ribose	0-6	myosin heavy chain 14	Homo sapiens	138-144
12628300-5	2002	The inhibition of PARG or ADP-ribose-degrading enzymes allowed the demonstration that in vitro synthesized 32P-poly(ADP-ribose) is first digested to ADP-ribose monomers by a typical PARG reaction, and that ADP-ribose is further rapidly converted into AMP by an Mg(2+)-dependent activity.	Ribose	30-36	poly(ADP-ribose) glycohydrolase	Homo sapiens	182-186
12628300-5	2002	The inhibition of PARG or ADP-ribose-degrading enzymes allowed the demonstration that in vitro synthesized 32P-poly(ADP-ribose) is first digested to ADP-ribose monomers by a typical PARG reaction, and that ADP-ribose is further rapidly converted into AMP by an Mg(2+)-dependent activity.	Ribose	120-126	poly(ADP-ribose) glycohydrolase	Homo sapiens	18-22
12628300-5	2002	The inhibition of PARG or ADP-ribose-degrading enzymes allowed the demonstration that in vitro synthesized 32P-poly(ADP-ribose) is first digested to ADP-ribose monomers by a typical PARG reaction, and that ADP-ribose is further rapidly converted into AMP by an Mg(2+)-dependent activity.	Ribose	120-126	poly(ADP-ribose) glycohydrolase	Homo sapiens	182-186
12628300-5	2002	The inhibition of PARG or ADP-ribose-degrading enzymes allowed the demonstration that in vitro synthesized 32P-poly(ADP-ribose) is first digested to ADP-ribose monomers by a typical PARG reaction, and that ADP-ribose is further rapidly converted into AMP by an Mg(2+)-dependent activity.	Ribose	120-126	poly(ADP-ribose) glycohydrolase	Homo sapiens	18-22
12628300-5	2002	The inhibition of PARG or ADP-ribose-degrading enzymes allowed the demonstration that in vitro synthesized 32P-poly(ADP-ribose) is first digested to ADP-ribose monomers by a typical PARG reaction, and that ADP-ribose is further rapidly converted into AMP by an Mg(2+)-dependent activity.	Ribose	120-126	poly(ADP-ribose) glycohydrolase	Homo sapiens	182-186
12403647-11	2003	Taken together, these results lead us to speculate that CD38 might have an intracellular location in neural cells in addition to its plasma membrane location, and may play an important role in intracellular cyclic ADP-ribose-mediated calcium signalling in brain tissue.	Ribose	218-224	CD38 antigen	Mus musculus	56-60
12519059-3	2003	In vitro inhibition of PARP-1 was confirmed by direct measurement of NAD+ depletion and ADP-ribose polymer formation caused by chemically induced DNA damage.	Ribose	92-98	poly(ADP-ribose) polymerase 1	Homo sapiens	23-29
12370179-9	2002	The inability of OAADPr to inhibit the reaction of NUDT9 with ADP-ribose suggests that NUDT9 binds OAADPr with low affinity, likely due to steric considerations of the additional acetylated-ribose moiety.	Ribose	66-72	nudix hydrolase 9	Homo sapiens	87-92
12440774-1	2002	Mammalian poly(ADP-ribose)polymerase 1 (PARP-1) is an abundant nuclear chromatin-associated protein and belongs to a large family of enzymes that catalyzes the transfer of ADP-ribose units from its substrate beta-nicotinamide adenine dinucleotide (NAD+) covalently to itself and other nuclear chromatin-associated proteins.	Ribose	19-25	poly(ADP-ribose) polymerase 1	Homo sapiens	40-46
12218186-6	2002	These results demonstrate that glucose and ribose increase islet peroxide accumulation and that the adverse consequences of ribose-induced oxidative stress on insulin mRNA, content, and secretion can be augmented by a glutathione synthesis inhibitor and prevented by increasing islet GPx activity.	Ribose	124-130	insulin	Homo sapiens	159-166
12057661-4	2002	In these substrates the fused cyclopropane moiety constrains the cyclopentane ring to mimic the conformation of a furanose sugar in the North hemisphere of the pseudorotational cycle, which matches the conformation of the ribose ring of adenosine in complex with ADA.	Ribose	222-228	adenosine deaminase	Homo sapiens	263-266
12204118-1	2002	In order to elucidate the molecular basis of energy transduction by myosin as a molecular motor, a fluorescent ribose-modified ATP analog 2"(3")-O-[6-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl]-ATP (NBD-ATP), was utilized to study the conformational change of the myosin motor domain during ATP hydrolysis using the fluorescence resonance energy transfer (FRET) method.	Ribose	111-117	myosin heavy chain 14	Homo sapiens	68-74
12204118-1	2002	In order to elucidate the molecular basis of energy transduction by myosin as a molecular motor, a fluorescent ribose-modified ATP analog 2"(3")-O-[6-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl]-ATP (NBD-ATP), was utilized to study the conformational change of the myosin motor domain during ATP hydrolysis using the fluorescence resonance energy transfer (FRET) method.	Ribose	111-117	myosin heavy chain 14	Homo sapiens	274-280
12110519-2	2002	In the present work, we studied the substrate specificities of the human and rat orthologs of the Na+-dependent purine-selective nucleoside transporter (SPNT; concentrative nucleoside transporter 2), for nucleosides, nucleobases, and base- and ribose-modified nucleoside analogs.	Ribose	244-250	solute carrier family 28 member 2	Rattus norvegicus	153-157
12110519-8	2002	The ribose-modified nucleoside analogs, adenine arabinoside, and 2",3"-dideoxyadenosine induced currents in rSPNT-expressing, but not in hSPNT1-expressing, oocytes.	Ribose	4-10	solute carrier family 28 member 2	Rattus norvegicus	108-113
12110519-8	2002	The ribose-modified nucleoside analogs, adenine arabinoside, and 2",3"-dideoxyadenosine induced currents in rSPNT-expressing, but not in hSPNT1-expressing, oocytes.	Ribose	4-10	solute carrier family 28 member 2	Homo sapiens	137-143
12139449-1	2002	O(6)-substituted guanines are adenosine 5"-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site.	Ribose	164-170	cyclin dependent kinase 1	Homo sapiens	88-92
12139449-1	2002	O(6)-substituted guanines are adenosine 5"-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site.	Ribose	164-170	cyclin B1	Homo sapiens	93-102
12139449-1	2002	O(6)-substituted guanines are adenosine 5"-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site.	Ribose	164-170	cyclin dependent kinase 2	Homo sapiens	107-111
12139449-1	2002	O(6)-substituted guanines are adenosine 5"-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site.	Ribose	164-170	cyclin A2	Homo sapiens	112-120
12051667-1	2002	Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which is activated in response to genotoxic insults by binding damaged DNA and attaching polymers of ADP-ribose to nuclear proteins at the expense of its substrate NAD+.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	29-33
12146911-15	2002	An acid hydrolysis mechanism was proposed for the formation of As(254) from each of the native arsenosugars by hydrolysis at the C-1 carbon on the ribose ring.	Ribose	147-153	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	129-132
12038988-1	2002	A new fluorescent ribose-modified ATP analogue, 2"(3")-O-[6-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoic]-ATP (NBD-ATP), was synthesized and its interaction with skeletal muscle myosin subfragment-1 (S-1) was studied.	Ribose	18-24	myosin heavy chain 14	Homo sapiens	186-192
11985476-1	2002	Preference for the Northern (N) ring conformation of the ribose moiety of nucleotide 5"-triphosphate agonists at P2Y(1), P2Y(2), P2Y(4), and P2Y(11) receptors, but not P2Y(6) receptors, was established using a ring-constrained methanocarba (a 3.1.0-bicyclohexane) ring as a ribose substitute (Kim et al.	Ribose	57-63	purinergic receptor P2Y1	Rattus norvegicus	113-119
11985476-1	2002	Preference for the Northern (N) ring conformation of the ribose moiety of nucleotide 5"-triphosphate agonists at P2Y(1), P2Y(2), P2Y(4), and P2Y(11) receptors, but not P2Y(6) receptors, was established using a ring-constrained methanocarba (a 3.1.0-bicyclohexane) ring as a ribose substitute (Kim et al.	Ribose	57-63	purinergic receptor P2Y2	Rattus norvegicus	121-127
11985476-1	2002	Preference for the Northern (N) ring conformation of the ribose moiety of nucleotide 5"-triphosphate agonists at P2Y(1), P2Y(2), P2Y(4), and P2Y(11) receptors, but not P2Y(6) receptors, was established using a ring-constrained methanocarba (a 3.1.0-bicyclohexane) ring as a ribose substitute (Kim et al.	Ribose	57-63	pyrimidinergic receptor P2Y4	Rattus norvegicus	129-135
11846617-1	2002	Poly(ADP-ribose) polymerases (PARPs) are defined as cell signaling enzymes that catalyze the transfer of ADP-ribose units from NAD(+)to a number of acceptor proteins.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	30-35
11853409-1	2002	Poly(ADP-ribose) polymerase-1 (PARP-1) is a chromatin-associated enzyme that is activated by DNA strand breaks and catalyzes the transfer of ADP-ribose groups from NAD to itself and other nuclear proteins.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	31-37
11754592-1	2002	The potency of nucleotide antagonists at P2Y1 receptors was enhanced by replacing the ribose moiety with a constrained carbocyclic ring (Nandanan, et al.	Ribose	86-92	purinergic receptor P2Y1	Homo sapiens	41-45
11959804-2	2002	We reported previously that bisphosphate derivatives of adenosine are antagonists of the P2Y(1) receptor and that modification of the ribose in these analogues is tolerated in the P2Y(1) receptor binding pharmacophore.	Ribose	134-140	purinergic receptor P2Y1	Homo sapiens	89-104
11959804-2	2002	We reported previously that bisphosphate derivatives of adenosine are antagonists of the P2Y(1) receptor and that modification of the ribose in these analogues is tolerated in the P2Y(1) receptor binding pharmacophore.	Ribose	134-140	purinergic receptor P2Y1	Homo sapiens	180-195
12365458-2	2002	50 mM D-fructose or D-ribose gradually inhibited pig heart AST under the same conditions to zero activity after 14 days.	Ribose	20-28	AST	Sus scrofa	59-62
11989624-6	2001	The bound pteridine ring of folate (Fol I) from the crystal structure of R67 DHFR was used as the basis for docking the nicotinamide-ribose-Pi (NMN) moiety of NADPH.	Ribose	133-139	dihydrofolate reductase	Homo sapiens	77-81
12365458-4	2002	The inhibition of pig heart AST by 50 mM D-fructose or D-ribose was marked even at a temperature of 4 degrees C but it was less pronounced than at 25 degrees C. There was no effect of 0.5 mM 2-oxoglutarate on AST activity during incubation, while the presence of 25 mM L-aspartate decreased it rapidly.	Ribose	55-63	AST	Sus scrofa	28-31
12365458-4	2002	The inhibition of pig heart AST by 50 mM D-fructose or D-ribose was marked even at a temperature of 4 degrees C but it was less pronounced than at 25 degrees C. There was no effect of 0.5 mM 2-oxoglutarate on AST activity during incubation, while the presence of 25 mM L-aspartate decreased it rapidly.	Ribose	55-63	AST	Sus scrofa	209-212
12365458-5	2002	0.5 mM 2-oxoglutarate partly prevented inhibition of AST by D-ribose or D-fructose, while an analogous experiment with 25 mM aspartate resulted in a rapid decline similar to that in the absence of sugars.	Ribose	60-68	AST	Sus scrofa	53-56
11796141-7	2001	The initiation of the reaction by removal of the 3"-hydrogen of the ribose by a transient cysteinyl radical is a common feature of the different classes of RNR.	Ribose	68-74	nuclear receptor subfamily 2 group E member 3	Homo sapiens	156-159
11489902-5	2001	The decrease in 13C label incorporation into RNA ribose was accompanied by a significant fall in hexokinase and glucose-6-phosphate 1-dehydrogenase activities.	Ribose	49-55	hexokinase 1	Homo sapiens	97-107
11489902-5	2001	The decrease in 13C label incorporation into RNA ribose was accompanied by a significant fall in hexokinase and glucose-6-phosphate 1-dehydrogenase activities.	Ribose	49-55	glucose-6-phosphate dehydrogenase	Homo sapiens	112-147
11489902-6	2001	The activity of transketolase, the enzyme responsible for nonoxidative ribose synthesis in the pentose cycle, was less affected, and there was a relative increase in glucose carbon incorporation into RNA through nonoxidative synthesis as indicated by the increase in the m2/Sigma(m)n ratio in RNA.	Ribose	71-77	transketolase	Homo sapiens	16-29
12440703-5	2002	hENT1 and hENT2 tolerated halogen modification at the 5 position of the base and the 2" and 5" positions of the ribose moieties of uridine whereas removal of the hydroxyl group at the 3" position of the ribose moiety of uridine eliminated interaction with both transporters.	Ribose	112-118	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-5
12440703-5	2002	hENT1 and hENT2 tolerated halogen modification at the 5 position of the base and the 2" and 5" positions of the ribose moieties of uridine whereas removal of the hydroxyl group at the 3" position of the ribose moiety of uridine eliminated interaction with both transporters.	Ribose	112-118	solute carrier family 29 member 2	Homo sapiens	10-15
12440703-5	2002	hENT1 and hENT2 tolerated halogen modification at the 5 position of the base and the 2" and 5" positions of the ribose moieties of uridine whereas removal of the hydroxyl group at the 3" position of the ribose moiety of uridine eliminated interaction with both transporters.	Ribose	203-209	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-5
12440703-5	2002	hENT1 and hENT2 tolerated halogen modification at the 5 position of the base and the 2" and 5" positions of the ribose moieties of uridine whereas removal of the hydroxyl group at the 3" position of the ribose moiety of uridine eliminated interaction with both transporters.	Ribose	203-209	solute carrier family 29 member 2	Homo sapiens	10-15
11513738-4	2001	In the present study we wanted to test whether the CD38-cADPR complex is kinetically competent in the conversion of NAD(+) into the reaction product ADP-ribose.	Ribose	153-159	CD38 molecule	Homo sapiens	51-55
12650200-6	2001	Moreover, PARP-1 can control its protein and DNA interactions by catalyzing its automodification with poly(ADP-ribose) molecules that can include up to 200 ADP-ribose residues and several branching points; by these polymers, PARP-1 may nocovalently interact with other proteins and alter their functions.	Ribose	111-117	poly (ADP-ribose) polymerase 1	Rattus norvegicus	10-16
11488910-3	2001	Thiamine (vitamin B1) is metabolized to thiamine pyrophosphate, the cofactor of transketolase, which is involved in ribose synthesis, necessary for cell replication.	Ribose	116-122	transketolase	Mus musculus	80-93
12650200-6	2001	Moreover, PARP-1 can control its protein and DNA interactions by catalyzing its automodification with poly(ADP-ribose) molecules that can include up to 200 ADP-ribose residues and several branching points; by these polymers, PARP-1 may nocovalently interact with other proteins and alter their functions.	Ribose	111-117	poly (ADP-ribose) polymerase 1	Rattus norvegicus	225-231
11248084-1	2001	Poly(ADP-ribose) polymerase-1 (PARP-1; EC ) is an abundant nuclear enzyme, activated by DNA strand breaks to attach up to 200 ADP-ribose groups to nuclear proteins.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	31-37
11385575-0	2001	ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology.	Ribose	4-10	transient receptor potential cation channel subfamily M member 2	Homo sapiens	43-49
11329299-13	2001	The results are interpreted in terms of an interaction between the ribose ring of C25 and the ribose and base of A10, in agreement with the proposal of Ryder and Strobel [Ryder, S. P., and Strobel, S. A.	Ribose	67-73	anon-23Cc	Drosophila melanogaster	82-85
11333014-5	2001	Here, on the basis of phylogenetic, structural, and molecular dynamics data, we discuss a conserved interaction established between the ribose of the U33 and the base at position 35, either a purine or a pyrimidine.	Ribose	136-142	small nucleolar RNA, C/D box 33	Homo sapiens	150-153
11329299-13	2001	The results are interpreted in terms of an interaction between the ribose ring of C25 and the ribose and base of A10, in agreement with the proposal of Ryder and Strobel [Ryder, S. P., and Strobel, S. A.	Ribose	67-73	antennal protein 10	Drosophila melanogaster	113-116
11329299-13	2001	The results are interpreted in terms of an interaction between the ribose ring of C25 and the ribose and base of A10, in agreement with the proposal of Ryder and Strobel [Ryder, S. P., and Strobel, S. A.	Ribose	94-100	anon-23Cc	Drosophila melanogaster	82-85
11062073-0	2000	Angiotensin II stimulates cyclic ADP-ribose formation in neonatal rat cardiac myocytes.	Ribose	37-43	angiotensinogen	Rattus norvegicus	0-14
11456577-3	2001	As a practical application, two- and three-dimensional versions of the HCN triple resonance experiment for obtaining ribose-base and intrabase correlations in the nucleotides of DNA and RNA (Sklenar, V.; Peterson, R. D.; Rejante, M. R.; Feigon, J. J. Biomol.	Ribose	117-123	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	71-74
11456577-6	2001	Compared to the best previous implementations of the HCN experiment, 2-fold and 5-fold sensitivity enhancements have been achieved for ribose-base and intrabase connectivities, respectively, for (13)C,(15)N-labeled nucleotides in structures with molecular weights of 10 and 17 kDa.	Ribose	135-141	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	53-56
11563046-4	2001	Conformational constraints were built into the ribose rings of nucleoside and nucleotide ligands using the methanocarba approach, i.e. fused cyclopropane and cyclopentane rings in place of ribose, suggesting a preference for the Northern (N) conformation among ligands for P2Y1 and A1 and A3ARs.	Ribose	47-53	purinergic receptor P2Y1	Homo sapiens	273-294
11563694-3	2001	We now present evidence that the catalytic activity of E. coli ribokinase is also affected by PVI, increasing both the velocity and affinity of the enzyme for D-ribose.	Ribose	159-167	ribokinase	Homo sapiens	63-73
11016934-2	2000	PARP-1, the best understood and until recently the only known member of this family, is a DNA damage signal protein catalyzing its automodification with multiple, variably sized ADP-ribose polymers that may contain up to 200 residues and several branching points.	Ribose	182-188	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
11062073-7	2000	These results demonstrate the existence of a signalling pathway from Ang II receptors to membrane-bound ADP-ribosyl cyclase in the ventricular muscle cell and suggest that the Ang II-induced increase in cADP-ribose synthesis is involved in the regulation of cardiac function and development.	Ribose	208-214	angiotensinogen	Rattus norvegicus	69-75
11062073-7	2000	These results demonstrate the existence of a signalling pathway from Ang II receptors to membrane-bound ADP-ribosyl cyclase in the ventricular muscle cell and suggest that the Ang II-induced increase in cADP-ribose synthesis is involved in the regulation of cardiac function and development.	Ribose	208-214	angiotensinogen	Rattus norvegicus	176-182
10869342-5	2000	Here we show that CobU requires a nucleoside upper ligand on cobinamide for substrate recognition, with the nucleoside base, but not the 2"-OH group of the ribose, being important for this recognition.	Ribose	156-162	bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	18-22
11011142-2	2000	Without an added ADP-ribose acceptor, Rt6.2 shows NAD glycohydrolase (NADase) activity.	Ribose	21-27	ADP-ribosyltransferase 2a	Mus musculus	38-41
10958667-1	2000	Poly(ADP-ribose) polymerase (PARP) is a DNA binding zinc finger protein that catalyzes the transfer of ADP-ribose residues from NAD(+) to itself and different chromatin constituents, forming branched ADP-ribose polymers.	Ribose	9-15	poly (ADP-ribose) polymerase family, member 1	Mus musculus	29-33
11185961-2	2000	The [32P]ADP-ribose polymers synthesized were chemically detached from PARP by alkaline hydrolysis of the monoester bond between the carboxylate moiety of Glu and the polymer.	Ribose	13-19	poly(ADP-ribose) polymerase 1	Homo sapiens	71-75
11185961-9	2000	Therefore, we conclude that high concentrations of PARP lead to acceptor substrate inhibition at the level of the ADP-ribose chain initiation reaction.	Ribose	118-124	poly(ADP-ribose) polymerase 1	Homo sapiens	51-55
10861229-8	2000	For the Aplysia enzyme"s catalysed transformation of NAD(+) we favour a mechanism where the formation of cADP-ribose precedes that of ADP-ribose; i.e. macroscopically the invertebrate ADP-ribosyl cyclase conforms to a sequential reaction pathway as a limiting form of the partitioning mechanism.	Ribose	110-116	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase	Aplysia californica	184-203
10814955-1	2000	Poly(ADP-ribose) polymerase (PARP) catalyzes the transfer of successive units of ADP-ribose moiety from NAD(+) covalently to itself and other nuclear acceptor proteins.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	29-33
10814545-3	2000	We find that ribose and adenine, two major parts of the adenosine nucleotide, bind tightly to phenol sulfotransferase (PST) separately, and various nucleotides also bind tightly to PST.	Ribose	13-19	sulfotransferase family 1A member 1	Homo sapiens	94-117
10814545-3	2000	We find that ribose and adenine, two major parts of the adenosine nucleotide, bind tightly to phenol sulfotransferase (PST) separately, and various nucleotides also bind tightly to PST.	Ribose	13-19	sulfotransferase family 1A member 1	Homo sapiens	119-122
10814545-3	2000	We find that ribose and adenine, two major parts of the adenosine nucleotide, bind tightly to phenol sulfotransferase (PST) separately, and various nucleotides also bind tightly to PST.	Ribose	13-19	sulfotransferase family 1A member 1	Homo sapiens	181-184
10841343-2	2000	PARG is the key enzyme degrading ADP-ribose polymers produced by PARP.	Ribose	37-43	poly (ADP-ribose) glycohydrolase	Mus musculus	0-4
10841343-2	2000	PARG is the key enzyme degrading ADP-ribose polymers produced by PARP.	Ribose	37-43	poly (ADP-ribose) polymerase family, member 1	Mus musculus	65-69
10728670-0	2000	Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells.	Ribose	89-95	transforming growth factor beta 2	Homo sapiens	0-32
10691699-4	2000	Specifically, the binding site of the P2Y(1) receptor was found to be sufficiently accommodating to allow the substitution of the ribose group with acyclic aliphatic and aromatic chains attached to the 9-position of adenine.	Ribose	130-136	P2Y purinoceptor 1	Meleagris gallopavo	38-44
10482770-0	1999	Induction of hippocampal LTD requires nitric-oxide-stimulated PKG activity and Ca2+ release from cyclic ADP-ribose-sensitive stores.	Ribose	108-114	carbonic anhydrase 2	Homo sapiens	79-82
10685339-1	1999	A multiple-quantum 3D HCN-CCH-TOCSY experiment is presented for the assignment of RNA ribose resonances.	Ribose	86-92	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	22-25
10851782-0	2000	Physiological and pathological significance of the CD38-cyclic ADP-ribose signaling system.	Ribose	67-73	CD38 molecule	Homo sapiens	51-55
10542202-7	1999	Based on the change in mobility of auto-ADP-ribosylated ART5 by SDS-polyacrylamide gel electrophoresis, the modification appeared to be stoichiometric and resulted in the addition of at least two ADP-ribose moieties.	Ribose	200-206	ADP-ribosyltransferase 5	Homo sapiens	56-60
10471503-2	1999	DNA binding by PARP triggers primarily its own modification by the sequential addition of ADP-ribose units to form polymers; this modification, in turn, causes the release of PARP from DNA ends.	Ribose	94-100	poly (ADP-ribose) polymerase family, member 1	Mus musculus	15-19
10471503-2	1999	DNA binding by PARP triggers primarily its own modification by the sequential addition of ADP-ribose units to form polymers; this modification, in turn, causes the release of PARP from DNA ends.	Ribose	94-100	poly (ADP-ribose) polymerase family, member 1	Mus musculus	175-179
10364226-2	1999	There is now evidence that cADP-ribose may be an endogenous regulator of the Ca2+ release channel of the sarcoplasmic reticulum (the ryanodine receptor), raising the possibility that cADP-ribose may influence arrhythmogenic mechanisms in the heart.	Ribose	31-38	carbonic anhydrase 2	Homo sapiens	77-80
10409619-12	1999	However, addition of C-2 compounds greatly catalyzes vesperlysine A formation from ribose.	Ribose	83-89	complement C2	Homo sapiens	21-24
10407144-7	1999	(d) The specific interactions that occur between GAPDH and the tRNA(Phe) involve, mainly, stacking between nucleobases and aromatic amino-acid residues, and ionic interactions of basic amino-acid residues with phosphate groups of the ribose-phosphate backbone.	Ribose	234-240	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	49-54
9746368-0	1998	Characterization of the interaction of myosin with ATP analogues having the syn conformation with respect to the adenine-ribose bond.	Ribose	121-127	myosin heavy chain 14	Homo sapiens	39-45
10199955-2	1999	Upon DNA damage PARP binds to DNA strand breaks and transfers ADP-ribose residues from NAD+ to acceptor proteins and to ADP-ribosyl protein adducts.	Ribose	66-72	Poly-(ADP-ribose) polymerase	Drosophila melanogaster	16-20
10082530-1	1999	Mammalian poly(ADP-ribose) polymerase (PARP) is a nuclear chromatin-associated protein with a molecular mass of 114 kDa that catalyzes the transfer of ADP-ribose units from NAD+ to nuclear proteins that are located within chromatin.	Ribose	19-25	poly(ADP-ribose) polymerase 1	Homo sapiens	39-43
10090736-7	1999	In meta-binding site I, the side chain of Glu209 (EL2) is within hydrogen-bonding distance (2.8 A) of the ribose O3", and Arg287 (EL3) coordinates both alpha- and beta-phosphates of the triphosphate chain, consistent with the insensitivity in potency of the 5"-monophosphate agonist, HT-AMP, to mutation of Arg287 to Lys.	Ribose	106-112	spectrin alpha, erythrocytic 1	Homo sapiens	50-53
10068454-7	1999	Finally, the structural components of the attached ADP-ribose moiety responsible for altering the assembly of desmin into filaments were investigated by a stepwise cleavage of ADP-ribose with snake venom phosphodiesterase and alkaline phophatase, followed by analysis of assembly.	Ribose	55-61	desmin	Homo sapiens	110-116
10049496-8	1999	Because residues similar to Lys 782 in the sequences of mitogen-activated protein kinase and insulin receptor make contact with a ribose hydroxyl of ATP, it is proposed that Lys 782 may be one of the residues composing the ribose-binding site of epidermal growth factor receptor.	Ribose	130-136	insulin receptor	Homo sapiens	93-109
10049496-8	1999	Because residues similar to Lys 782 in the sequences of mitogen-activated protein kinase and insulin receptor make contact with a ribose hydroxyl of ATP, it is proposed that Lys 782 may be one of the residues composing the ribose-binding site of epidermal growth factor receptor.	Ribose	130-136	epidermal growth factor receptor	Homo sapiens	246-278
9920910-9	1999	Using computer modeling based on the structure of rhodopsin, a revised model of adenosine-A1AR interactions is proposed with the N6-adenine position oriented toward the top of TM3 and the ribose group interacting with the bottom half of TMs 3 and 7.	Ribose	188-194	rhodopsin	Homo sapiens	50-59
9952450-6	1999	When scavenging phosphate from xATP, apyrase mobilizes the gamma-phosphate without promoting the transport of the purine or the ribose.	Ribose	128-134	apyrase	Saccharomyces cerevisiae S288C	37-44
9748331-2	1998	Human recombinant CD38 catalyzes the formation of both cyclic ADP-ribose and ADP-ribose products from NAD+ and hydrolyzes cyclic ADP-ribose to ADP-ribose.	Ribose	66-72	CD38 molecule	Homo sapiens	18-22
10331632-6	1999	The inhibition of PARG was presumably due to the non-covalent interactions of these proteins with free ADP-ribose polymers.	Ribose	107-113	poly (ADP-ribose) glycohydrolase	Rattus norvegicus	18-22
10331633-2	1999	A detailed kinetic analysis of the automodification reaction of PARP in the presence of nicked dsDNA indicates that protein-poly(ADP-ribosyl)ation probably occurs via a sequential mechanism since enzyme-bound ADP-ribose chains are not reaction intermediates.	Ribose	213-219	poly(ADP-ribose) polymerase 1	Homo sapiens	64-68
9746368-0	1998	Characterization of the interaction of myosin with ATP analogues having the syn conformation with respect to the adenine-ribose bond.	Ribose	121-127	synemin	Homo sapiens	76-79
9746368-1	1998	Numerous analytical experiments have shown that, in solution, ATP analogues with bulky substitutions at the eighth position of the adenine ring predominantly assume the syn conformation with respect to the adenine-ribose bond.	Ribose	214-220	synemin	Homo sapiens	169-172
9494110-5	1998	We find that CD38-catalysed cleavage of the nicotinamide-ribose bond results in the formation of an E.ADP-ribosyl intermediary complex, which is common to all reaction pathways; this intermediate reacts (1) with acceptors such as water (hydrolysis), methanol (methanolysis) or pyridine (transglycosidation), and (2) intramolecularly, yielding cyclic ADP-ribose with a low efficiency.	Ribose	57-63	CD38 molecule	Homo sapiens	13-17
9628920-0	1998	Cap ribose methylation of c-mos mRNA stimulates translation and oocyte maturation in Xenopus laevis.	Ribose	4-10	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	26-31
9654134-0	1998	Thrombin induces the association of cyclic ADP-ribose-synthesizing CD38 with the platelet cytoskeleton.	Ribose	47-53	coagulation factor II, thrombin	Homo sapiens	0-8
9654134-0	1998	Thrombin induces the association of cyclic ADP-ribose-synthesizing CD38 with the platelet cytoskeleton.	Ribose	47-53	CD38 molecule	Homo sapiens	67-71
9612242-9	1998	The observed ribose isotopomer distribution was best matched with that provided from simulation by substituting 0.032 for TK and 0.85 for TA activity relative to glucose uptake into the model of Katz and Rognstad.	Ribose	13-19	transketolase	Homo sapiens	122-124
9612242-9	1998	The observed ribose isotopomer distribution was best matched with that provided from simulation by substituting 0.032 for TK and 0.85 for TA activity relative to glucose uptake into the model of Katz and Rognstad.	Ribose	13-19	transaldolase 1	Homo sapiens	138-140
9703018-1	1998	U24 and U36 are members of the box C/D-containing group of antisense snoRNAs which possess long (9-21 nucleotide) conserved stretches of sequence complementarity to 18S and 28S rRNA and act as guides for the site-specific ribose methylation of rRNA.	Ribose	222-228	small nucleolar RNA, C/D box 24	Homo sapiens	0-3
9703018-1	1998	U24 and U36 are members of the box C/D-containing group of antisense snoRNAs which possess long (9-21 nucleotide) conserved stretches of sequence complementarity to 18S and 28S rRNA and act as guides for the site-specific ribose methylation of rRNA.	Ribose	222-228	small nucleolar RNA, C/D box 3 pseudogene 4	Homo sapiens	8-11
9554879-13	1998	According to our model TM6 and TM7 are close to the adenine ring, TM3 and TM6 are close to the ribose moiety, and TM3, TM6, and TM7 are near the triphosphate chain.	Ribose	95-101	tropomyosin 3	Homo sapiens	66-69
9438984-1	1997	Human Cu,Zn-superoxide dismutase (SOD) was incubated with various intermediates of the Maillard reaction and glycolytic pathway (arabinose, glyoxal, glycolaldehyde, glyceraldehyde, glyceraldehyde 3-phosphate, and dihydroxyacetone) and some reducing sugars (sorbose, xylose, and ribose).	Ribose	278-284	superoxide dismutase 1	Homo sapiens	6-32
9438984-1	1997	Human Cu,Zn-superoxide dismutase (SOD) was incubated with various intermediates of the Maillard reaction and glycolytic pathway (arabinose, glyoxal, glycolaldehyde, glyceraldehyde, glyceraldehyde 3-phosphate, and dihydroxyacetone) and some reducing sugars (sorbose, xylose, and ribose).	Ribose	278-284	superoxide dismutase 1	Homo sapiens	34-37
9374868-9	1997	There are also significant differences in the conformation of the adenine-ribose moiety of NADPH in both complexes that differ from that observed for other inhibitor-NADPH-hDHFR ternary complexes.	Ribose	74-80	dihydrofolate reductase	Homo sapiens	172-177
9351810-8	1997	In E. coli PNP, the purine- and ribose-binding sites are generally hydrophobic, although a histidine residue from an adjacent subunit probably forms a hydrogen bond with a hydroxyl group of the sugar.	Ribose	32-38	purine nucleoside phosphorylase	Homo sapiens	11-14
9333033-1	1997	5"-Deoxy-5"-(methylthio)adenosine (MTA), a key by-product of polyamine biosynthesis, is cleaved by MTA phosphorylase and is salvaged as adenine and, through conversion of the ribose moiety, methionine.	Ribose	175-181	methylthioadenosine phosphorylase	Mus musculus	99-116
9568183-5	1998	The medical literature reveals little information regarding the role of the thiamine dependent TK reaction in tumor cell ribose production which is a central process in de novo nucleic acid synthesis and the salvage pathways for purines.	Ribose	121-127	transketolase	Homo sapiens	95-97
9331084-1	1997	This study investigates the significance of the glucose-6-phosphate dehydrogenase (G6PD) catalyzed oxidative and the transketolase (TK) catalyzed nonoxidative pentose cycle (PC) reactions in the tumor proliferation process by characterizing tumor growth patterns and synthesis of the RNA ribose moiety in the presence of respective inhibitors of G6PD and TK.	Ribose	288-294	transketolase	Mus musculus	117-130
9331084-1	1997	This study investigates the significance of the glucose-6-phosphate dehydrogenase (G6PD) catalyzed oxidative and the transketolase (TK) catalyzed nonoxidative pentose cycle (PC) reactions in the tumor proliferation process by characterizing tumor growth patterns and synthesis of the RNA ribose moiety in the presence of respective inhibitors of G6PD and TK.	Ribose	288-294	transketolase	Mus musculus	132-134
9331084-5	1997	RNA ribose fractional synthesis through the TK reaction using metabolites directly from glycolysis declined by 9.1 and 23.9% after OT or the combined treatment, respectively.	Ribose	4-10	transketolase	Mus musculus	44-46
11536828-3	1997	Since uracil reacts rapidly with formaldehyde and other aldehydes at the C-5 position, it is plausible that pseudouridine could be synthesized in a similar way by the reaction of the C-5 of uracil with the C-1 of ribose.	Ribose	213-219	complement C5	Homo sapiens	183-186
11536828-3	1997	Since uracil reacts rapidly with formaldehyde and other aldehydes at the C-5 position, it is plausible that pseudouridine could be synthesized in a similar way by the reaction of the C-5 of uracil with the C-1 of ribose.	Ribose	213-219	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	206-209
9255067-4	1997	Ribose methylation can also be targeted to non-rRNA sequences by tailored snoRNA guides, possibly providing a highly selective tool for altering gene expression at the post-transcriptional level.	Ribose	0-6	small nucleolar RNA, C/D box 14E	Homo sapiens	74-80
9354374-4	1997	GAPDH was modified equally with [adenosine-14C]NAD+ and [carbonyl-14C]NAD+, indicating that the glycoside bond of NAD+ between ADP-ribose and nicotinamide is intact.	Ribose	131-137	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-5
9326491-8	1997	Three-dimensional modeling of one IRE reveals that IRP-1 contacts several bases and the ribose-phosphate backbone located on one face in the deep groove, but contacts also exist with the shallow groove.	Ribose	88-94	aconitase 1	Homo sapiens	51-56
9133638-1	1997	Mobilization of the ribose moiety and of the amino group of guanosine may be realized in rat liver extract by the concerted action of purine nucleoside phosphorylase and guanase.	Ribose	20-26	guanine deaminase	Rattus norvegicus	170-177
9173879-3	1997	Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2.	Ribose	150-156	fibroblast growth factor 2	Homo sapiens	37-42
9173879-3	1997	Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2.	Ribose	150-156	fibroblast growth factor 2	Homo sapiens	162-167
9173879-3	1997	Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2.	Ribose	150-156	fibroblast growth factor 2	Homo sapiens	162-167
9173879-3	1997	Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2.	Ribose	253-259	fibroblast growth factor 2	Homo sapiens	37-42
9173879-3	1997	Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2.	Ribose	253-259	fibroblast growth factor 2	Homo sapiens	162-167
9173879-3	1997	Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2.	Ribose	253-259	fibroblast growth factor 2	Homo sapiens	162-167
8608601-0	1996	Inositol trisphosphate and cyclic ADP-ribose-mediated release of Ca2+ from single isolated pancreatic zymogen granules.	Ribose	38-44	carbonic anhydrase 2	Homo sapiens	65-68
9109647-6	1997	The positions of the pteridine and pABA rings of PT523 and the nicotinamide and ribose rings of NADPH are well defined in the solution structures (RMSD = 0.59 A) and are consistent with previously determined structures of DHFR complexes.	Ribose	80-86	dihydrofolate reductase	Homo sapiens	222-226
8916897-2	1996	Microcalorimetric measurements confirm that the binding affinity of acyl-CoA esters for ACBP is strongly dependent on the length of the acyl chain with a clear preference for acyl-CoA esters containing more than eight carbon atoms and that the 3"-phosphate of the ribose accounts for almost half of the binding energy.	Ribose	264-270	diazepam binding inhibitor, acyl-CoA binding protein	Bos taurus	88-92
8941705-1	1996	Poly(ADP-ribosyl) transferase (pADPRT) catalyzes the transfer of the ADP-ribose moiety from NAD+ onto proteins as well as onto protein-bound ADP-ribose.	Ribose	73-79	poly(ADP-ribose) polymerase 1	Homo sapiens	0-29
8941705-1	1996	Poly(ADP-ribosyl) transferase (pADPRT) catalyzes the transfer of the ADP-ribose moiety from NAD+ onto proteins as well as onto protein-bound ADP-ribose.	Ribose	73-79	poly(ADP-ribose) polymerase 1	Homo sapiens	31-37
8941705-1	1996	Poly(ADP-ribosyl) transferase (pADPRT) catalyzes the transfer of the ADP-ribose moiety from NAD+ onto proteins as well as onto protein-bound ADP-ribose.	Ribose	145-151	poly(ADP-ribose) polymerase 1	Homo sapiens	0-29
8941705-1	1996	Poly(ADP-ribosyl) transferase (pADPRT) catalyzes the transfer of the ADP-ribose moiety from NAD+ onto proteins as well as onto protein-bound ADP-ribose.	Ribose	145-151	poly(ADP-ribose) polymerase 1	Homo sapiens	31-37
8941705-3	1996	pADPRT itself contains several acceptor sites for ADP-ribose polymers and may attach polymers to itself (automodification).	Ribose	54-60	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
8901462-12	1996	The limiting step in the oxidative PPP, the G-6-PD reaction, can be bypassed with ribose.	Ribose	82-88	glucose-6-phosphate dehydrogenase	Rattus norvegicus	44-50
8709006-5	1996	Islet-activating protein (IAP, pertussis toxin, PTX) catalyses the transfer of the ADP-ribose moiety of NAD to the alpha subunit of Gi, resulting in a complete loss of the Gi functions.	Ribose	87-93	islet amyloid polypeptide	Homo sapiens	0-24
8709006-5	1996	Islet-activating protein (IAP, pertussis toxin, PTX) catalyses the transfer of the ADP-ribose moiety of NAD to the alpha subunit of Gi, resulting in a complete loss of the Gi functions.	Ribose	87-93	islet amyloid polypeptide	Homo sapiens	26-29
9011569-3	1997	The results of reporter gene analyses revealed that the insulin gene promoter is more sensitive to glycation than the control beta-actin gene promoter; approximately 50 and 80% of the insulin gene promoter activity was lost when the cells were kept for 3 d in the presence of 40 and 60 mM D-ribose, respectively.	Ribose	289-297	insulin	Homo sapiens	56-63
9011569-3	1997	The results of reporter gene analyses revealed that the insulin gene promoter is more sensitive to glycation than the control beta-actin gene promoter; approximately 50 and 80% of the insulin gene promoter activity was lost when the cells were kept for 3 d in the presence of 40 and 60 mM D-ribose, respectively.	Ribose	289-297	POTE ankyrin domain family member F	Homo sapiens	126-136
8900395-12	1996	Removal of more than three ADP-ribose groups results in partial restoration of desmin"s ability to form intermediate filaments.	Ribose	31-37	desmin	Homo sapiens	79-85
8900395-13	1996	It is necessary to remove all ADP-ribose groups from desmin to restore its complete ability to form intermediate filaments.	Ribose	34-40	desmin	Homo sapiens	53-59
8896999-6	1996	We found that purified elastin and a collagen-elastin preparation from the porcine thoracic aorta rapidly incorporated glucose and ribose, the extent increasing linearly with increasing concentration and reaching a maximum after 7 days at 37 degrees C. Biochemical analysis showed that about one of the five lysines available per elastin monomer was glycated after 12 days incubation at a sugar concentration of 250 mmol/l.	Ribose	131-137	elastin	Homo sapiens	23-30
8896999-6	1996	We found that purified elastin and a collagen-elastin preparation from the porcine thoracic aorta rapidly incorporated glucose and ribose, the extent increasing linearly with increasing concentration and reaching a maximum after 7 days at 37 degrees C. Biochemical analysis showed that about one of the five lysines available per elastin monomer was glycated after 12 days incubation at a sugar concentration of 250 mmol/l.	Ribose	131-137	elastin	Homo sapiens	46-53
8896999-6	1996	We found that purified elastin and a collagen-elastin preparation from the porcine thoracic aorta rapidly incorporated glucose and ribose, the extent increasing linearly with increasing concentration and reaching a maximum after 7 days at 37 degrees C. Biochemical analysis showed that about one of the five lysines available per elastin monomer was glycated after 12 days incubation at a sugar concentration of 250 mmol/l.	Ribose	131-137	elastin	Homo sapiens	46-53
8896999-9	1996	The greatest increase in stiffness was observed in the elastin-collagen preparation after ribose incubation (250 mmol/l for 1 month), where the slope, at large strain, increased by 56 +/- 19% (mean +/- SD, n = 12).	Ribose	90-96	elastin	Homo sapiens	55-62
8798627-0	1996	Regulation of cADP-ribose-induced Ca2+ release by Mg2+ and inorganic phosphate.	Ribose	19-25	mucin 7, secreted	Homo sapiens	50-53
8573568-2	1996	Specifically, the catalytic (C) domain of DT transfers the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive.	Ribose	63-69	eukaryotic translation elongation factor 2	Homo sapiens	86-105
8573568-2	1996	Specifically, the catalytic (C) domain of DT transfers the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive.	Ribose	63-69	eukaryotic translation elongation factor 2	Homo sapiens	107-111
8573568-6	1996	Residues 39-46 of the active-site loop of the C-domain become disordered upon NAD binding, suggesting a potential role for this loop in the recognition of the ADP-ribose acceptor substrate, EF-2.	Ribose	163-169	eukaryotic translation elongation factor 2	Homo sapiens	190-194
7626622-4	1995	Previously, we have shown that Glu-34 is required for catalytic activity, presumably by forming a hydrogen bond between the carboxylate group of glutamate and the 2"-hydroxyl group of ribose in the AMP moiety of FAD.	Ribose	184-190	FA complementation group D2	Homo sapiens	212-215
8907197-3	1996	The increase in ADP-ribose incorporation into RhoA due to KCl appeared in the presence of MgCl2 and was abolished by EDTA.	Ribose	20-26	ras homolog family member A	Homo sapiens	46-50
7491924-5	1995	Supplementation of the culture medium with ribose-5-phosphate or ribose abolished the stimulation of glycolysis and the pentose cycle by EGF but had no effect on proliferation.	Ribose	43-49	epidermal growth factor	Homo sapiens	137-140
7641178-0	1995	Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences.	Ribose	27-34	cellular tumor antigen p53	Cricetulus griseus	50-53
7603461-5	1995	Gluc(2,3",4")P3 can be visualized as a truncated version of adenophostin A, in which the 2"- and 3"-carbons of the ribose ring, with their terminal phosphate groups, are retained and the remainder of the adenosine residue is excised.	Ribose	115-121	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	0-4
8144525-4	1994	Since RT6.2 has significant amino acid identity with a GPI-anchored rabbit muscle NAD:arginine ADP-ribosyltransferase, RT6.2 was expressed in rat mammary adenocarcinoma cells and the ability of the expressed protein to catalyze ADP-ribose transfer reactions was examined.	Ribose	232-238	ADP-ribosyltransferase 2b	Rattus norvegicus	6-11
7859285-0	1995	ATP-dependent accumulation and inositol trisphosphate- or cyclic ADP-ribose-mediated release of Ca2+ from the nuclear envelope.	Ribose	69-75	carbonic anhydrase 2	Homo sapiens	96-99
7840641-3	1995	In this study, we have examined the role of one amino acid (Glu34) in human MAO B that is thought to play a crucial role in binding to the 2"-hydroxy group of ribose in the AMP moiety of FAD.	Ribose	159-165	monoamine oxidase B	Homo sapiens	76-81
7961800-0	1994	Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.	Ribose	43-49	CD38 molecule	Homo sapiens	78-82
8062255-1	1994	Poly(ADP-ribose) polymerase (PADPRP) catalyzes the transfer of multiple ADP-ribose units from NAD to nuclear histone and nonhistone proteins, a reaction that appears to be important in the rejoining of DNA strand breaks during DNA repair and replication.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	29-35
8593581-1	1995	CD38 is a lymphocyte differentiation antigen which is involved in the cyclic ADP-ribose-mediated second messenger system.	Ribose	81-87	CD38 molecule	Homo sapiens	0-4
7711157-3	1995	The primary structure of the 5-HTT was analyzed in 17 patients meeting DSM-III-R diagnostic criteria for major depressive or bipolar disorder and in 4 healthy controls using polymerase chain reaction (PCR-) amplification and sequencing of complementary deoxyribose nucleic acid (cDNA) synthesized from platelet 5-HTT messenger ribose nucleic acid (mRNA).	Ribose	258-264	solute carrier family 6 member 4	Homo sapiens	29-34
7870042-3	1995	Common to all PDEs tested, except for the calcium/calmodulin-dependent PDE (CaM-PDE, PDE1), is an interaction at the N1-position of cAMP and a distinct lack of binding to the 2"-hydroxyl group of the ribose moiety.	Ribose	200-206	aldehyde dehydrogenase 7 family member A1	Homo sapiens	14-17
7870042-3	1995	Common to all PDEs tested, except for the calcium/calmodulin-dependent PDE (CaM-PDE, PDE1), is an interaction at the N1-position of cAMP and a distinct lack of binding to the 2"-hydroxyl group of the ribose moiety.	Ribose	200-206	aldehyde dehydrogenase 7 family member A1	Homo sapiens	71-74
7578422-9	1995	Therefore, the dimeric structure of PARP also requires two molecules of bound NAD for efficient ADP-ribose polymerization.	Ribose	100-106	poly(ADP-ribose) polymerase 1	Homo sapiens	36-40
7578425-4	1995	Finally, we have evidence that very short oligomers and even monomers of ADP-ribose covalently bound to proteins can be removed by poly(ADP-ribose) glycohydrolase.	Ribose	77-83	poly(ADP-ribose) glycohydrolase	Homo sapiens	131-162
7988726-4	1994	202, 263-267] and proposed that this part of ADH is close to the 2"-phosphate on the ribose moiety of NADP+.	Ribose	85-91	Alcohol dehydrogenase	Drosophila melanogaster	45-48
7988726-8	1994	Our model of the 3D structure of the NAD(+)-binding region of ADH shows that Ala-46 is over 10 A from the ribose moiety of NAD+, which would suggest that there is little interaction between this residue and NAD+ and explain why its mutation to arginine has little effect on NAD+ binding.	Ribose	106-112	Alcohol dehydrogenase	Drosophila melanogaster	62-65
7898463-1	1994	ADP-ribosylation reaction, that is the transfer of the ADP-ribose moiety of NAD+ to acceptor protein, is catalyzed by two classes of ADP-ribosyltransferases, i.e., poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferases.	Ribose	59-65	poly(ADP-ribose) polymerase 1	Homo sapiens	164-191
7898466-3	1994	Instead, it was a non-competitive inhibitor of beta NAD+ in the ADP-ribose polymerization reaction catalyzed by PARP.	Ribose	68-74	poly(ADP-ribose) polymerase 1	Homo sapiens	112-116
7898472-4	1994	The direction of ADP-ribose chain growth as well as the molecular mechanism of the automodification reaction catalyzed by PARP are described.	Ribose	21-27	poly(ADP-ribose) polymerase 1	Homo sapiens	122-126
8144525-4	1994	Since RT6.2 has significant amino acid identity with a GPI-anchored rabbit muscle NAD:arginine ADP-ribosyltransferase, RT6.2 was expressed in rat mammary adenocarcinoma cells and the ability of the expressed protein to catalyze ADP-ribose transfer reactions was examined.	Ribose	232-238	ADP-ribosyltransferase 2b	Rattus norvegicus	119-124
8307191-2	1994	ADP-ribose moiety containing digoxigenin was transferred by pertussis toxin (IAP) to the alpha subunit of Gi (Gi alpha) from digoxigenin-conjugated NAD (DIG-NAD) in a beta gamma subunit-dependent manner.	Ribose	4-10	alkaline phosphatase, intestinal	Homo sapiens	77-80
7912696-3	1994	The glycosyl conformation of 3"-GMP is in the syn conformation, and the ribose adopts the O4"-endo pucker.	Ribose	72-78	5'-nucleotidase, cytosolic II	Homo sapiens	32-35
8266080-1	1993	The product of the PET56 nuclear gene of Saccharomyces cerevisiae was shown to be required for ribose methylation at a universally conserved nucleotide in the peptidyl transferase center of the mitochondrial large ribosomal RNA (21S rRNA).	Ribose	95-101	Mrm1p	Saccharomyces cerevisiae S288C	19-24
8258703-3	1993	PARP, which binds to and is activated by DNA strand breaks, catalyzes the removal of ADP-ribose from NAD+ and poly(ADP-ribosylation) of chromatin-associated acceptor proteins.	Ribose	89-95	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
8241176-2	1993	Purine nucleoside phosphorylase from calf spleen catalyzes the arsenolysis of inosine to form hypoxanthine and ribose 1-arsenate, which spontaneously hydrolyzes to ribose and arsenate.	Ribose	111-117	purine nucleoside phosphorylase	Bos taurus	0-31
8821708-4	1994	The stoichiometry of ADP-ribose incorporation into 21-kD MBP was 3.5 mol of ADP-ribose/mol MBP.	Ribose	25-31	myelin basic protein	Gallus gallus	57-60
8821708-4	1994	The stoichiometry of ADP-ribose incorporation into 21-kD MBP was 3.5 mol of ADP-ribose/mol MBP.	Ribose	25-31	myelin basic protein	Gallus gallus	91-94
8394137-4	1993	These results indicate that ecto-NADase may have a role as supplier of ADP-ribose for its uptake into the cells and that the cleavage of NAD by NADase is necessary for the ADP-ribose uptake by human erythrocytes.	Ribose	75-81	tripartite motif containing 33	Homo sapiens	28-32
8821708-4	1994	The stoichiometry of ADP-ribose incorporation into 21-kD MBP was 3.5 mol of ADP-ribose/mol MBP.	Ribose	80-86	myelin basic protein	Gallus gallus	57-60
8821708-4	1994	The stoichiometry of ADP-ribose incorporation into 21-kD MBP was 3.5 mol of ADP-ribose/mol MBP.	Ribose	80-86	myelin basic protein	Gallus gallus	91-94
8369271-5	1993	We find that ribose at the splice junction (U-1) and at the two adjacent positions with E1 (A-2, C-3) is important for reverse exon ligation.	Ribose	13-19	ATPase H+ transporting V0 subunit a2	Homo sapiens	92-100
8393658-7	1993	Arabinose, xylose, mannose, ribose, fructose and glucose 6-phosphate (but not mannitol) were also able to inactive the ATPase.	Ribose	28-34	dynein axonemal heavy chain 8	Homo sapiens	119-125
8344450-4	1993	Our in vitro experiments show that incubation of myofibrillar proteins with ribose results in sugar attachment to proteins and at the same time myofibrillar ATPase activity is lowered.	Ribose	76-82	dynein axonemal heavy chain 8	Homo sapiens	157-163
8485104-3	1993	Adenosine deaminase is found to bind more strongly to compound I than to compound II, therefore compound I is a stronger inhibitor than II, because the position of (5") OH on the ribose moiety decreases the inhibitory strength on the ring opened analogue.	Ribose	179-185	adenosine deaminase	Homo sapiens	0-19
8344450-8	1993	The dependence of ATPase activity of myofibrils incubated with ribose on the amount of 2-mercaptoethanol present suggests that also modification of SH groups is involved in enzyme inactivation.	Ribose	63-69	dynein axonemal heavy chain 8	Homo sapiens	18-24
1462359-1	1992	Poly(ADP-ribose)polymerase (PARP)-activity was assessed in vitro from the incorporation of the adenosine-diphosphate-ribose moiety of 14C-NAD+ in the acid-insoluble cell fraction.	Ribose	9-15	poly(ADP-ribose) polymerase 1	Gallus gallus	28-32
7680855-6	1993	data indicate that both the acyl chain and the CoA head group of acyl-CoA are involved in binding and that the 3"-phosphate group on the ribose moiety of acyl-CoA esters plays a crucial role in the binding of acyl-CoA to ACBP.	Ribose	137-143	diazepam binding inhibitor	Rattus norvegicus	221-225
8389211-0	1993	Substrate specificity of human RNase H1 and its role in excision repair of ribose residues misincorporated in DNA.	Ribose	75-81	ribonuclease H1	Homo sapiens	31-39
8389211-1	1993	Recently we have shown that the major isoform of RNase H in human cells, RNase H1, is able to cleave DNA substrates containing a single RNA-DNA base pair, an activity which appears to be involved in an excision repair system for the removal of ribose residues misincorporated into DNA.	Ribose	244-250	ribonuclease H1	Homo sapiens	73-81
1332884-1	1992	Specific binding of ATP to bovine serum albumin (BSA) is demonstrated employing ATP derivatives spin-labeled at either N6 or C8 of adenine ring or at the ribose moiety.	Ribose	154-160	albumin	Homo sapiens	34-47
1627539-2	1992	Purine nucleoside phosphorylase from calf spleen is a trimer which catalyzes the hydrolysis of inosine to hypoxanthine and ribose in the absence of inorganic phosphate.	Ribose	123-129	purine nucleoside phosphorylase	Bos taurus	0-31
1446679-4	1992	Furthermore, the radiolabel of auto-[32P]ADP-ribosylated GraPDH is removed by treatment with HgCl2, suggesting an ADP-ribose-cysteine bond.	Ribose	118-124	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	57-63
1334674-11	1992	In the free GMP acid, the ribose ring exhibits C3"-endo/anti conformer, while a C2"-endo/anti sugar pucker was found in the Na2-GMP and K2-GMP salts and a C3"-endo/anti conformation for the Li+, NH4+, Rb+ and Cs+ salts.	Ribose	26-32	5'-nucleotidase, cytosolic II	Homo sapiens	12-15
1334674-11	1992	In the free GMP acid, the ribose ring exhibits C3"-endo/anti conformer, while a C2"-endo/anti sugar pucker was found in the Na2-GMP and K2-GMP salts and a C3"-endo/anti conformation for the Li+, NH4+, Rb+ and Cs+ salts.	Ribose	26-32	5'-nucleotidase, cytosolic II	Homo sapiens	128-131
1334674-11	1992	In the free GMP acid, the ribose ring exhibits C3"-endo/anti conformer, while a C2"-endo/anti sugar pucker was found in the Na2-GMP and K2-GMP salts and a C3"-endo/anti conformation for the Li+, NH4+, Rb+ and Cs+ salts.	Ribose	26-32	5'-nucleotidase, cytosolic II	Homo sapiens	128-131
1504093-2	1992	The specificity of the yeast enzyme is more restricted than that of mammalian adenosine deaminase, particularly towards the ribose moiety and around position 6 and 1 of the substrate.	Ribose	124-130	adenosine deaminase	Homo sapiens	78-97
1993675-10	1991	These studies indicate that (i) rS1, purified from Escherichia coli, possesses biochemical properties similar to S1 subunit purified from pertussis toxin, (ii) amino acids 1-180 of the S1 subunit contain residues required for NAD binding, N-glycosidic cleavage, and transfer of ADP-ribose to transducin, and (iii) residues between 181 and 219 of the S1 subunit are required for efficient ADP-ribosyltransferase activity.	Ribose	282-288	retinoschisin 1	Rattus norvegicus	32-35
1430793-4	1992	In collagen, myosin and albumin incubated with 0.5 mol/l fructose, 0.5 mol/l ribose or 0.1 mol/l glyceraldehyde, protein concentration was not changed, as proved by the Conway microdiffusion technique; the Coomassie brilliant blue G-250 colour yield was up to 50% lower, depending on the protein used, and was decreased much less when proteins were incubated with less sugar.	Ribose	77-83	myosin heavy chain 14	Homo sapiens	13-19
1932015-7	1991	The data strongly suggest that the conformation of the nucleotide when bound to EF-Tu and that p21 is the C2" endo pucker of the ribose ring and anti about the glycosidic bond.	Ribose	129-135	H3 histone pseudogene 16	Homo sapiens	95-98
1929298-1	1991	We describe a novel nucleoside analog, 2"-deoxy-3"-thiacytidine (BCH-189), in which the 3" carbon of the ribose ring of 2"-deoxycytidine has been replaced by a sulfur atom.	Ribose	105-111	chimerin 2	Homo sapiens	65-68
2004328-2	1991	Previous studies found that hyperthermia alters the metabolism of adenosine diphosphate (ADP)-ribose polymers required for recovery from DNA damage and that poly(ADP-ribose) polymerase activity is very sensitive to cellular nicotinamide-adenine dinucleotide (NAD) levels.	Ribose	94-100	poly(ADP-ribose) polymerase 1	Homo sapiens	157-184
1851044-5	1991	The ribose moiety shows C3"-endo/anti conformation in the free acid; C2"-endo/anti in the Na2-GMP salt; C3"-endo/anti in the Mg(II)-, Ca(II)-, and Sr(II)-GMP salts; and C2"-endo/anti, in the Ba(II)-GMP salt.	Ribose	4-10	5'-nucleotidase, cytosolic II	Homo sapiens	94-97
1851044-5	1991	The ribose moiety shows C3"-endo/anti conformation in the free acid; C2"-endo/anti in the Na2-GMP salt; C3"-endo/anti in the Mg(II)-, Ca(II)-, and Sr(II)-GMP salts; and C2"-endo/anti, in the Ba(II)-GMP salt.	Ribose	4-10	carbonic anhydrase 2	Homo sapiens	134-139
1851044-5	1991	The ribose moiety shows C3"-endo/anti conformation in the free acid; C2"-endo/anti in the Na2-GMP salt; C3"-endo/anti in the Mg(II)-, Ca(II)-, and Sr(II)-GMP salts; and C2"-endo/anti, in the Ba(II)-GMP salt.	Ribose	4-10	5'-nucleotidase, cytosolic II	Homo sapiens	154-157
1851044-5	1991	The ribose moiety shows C3"-endo/anti conformation in the free acid; C2"-endo/anti in the Na2-GMP salt; C3"-endo/anti in the Mg(II)-, Ca(II)-, and Sr(II)-GMP salts; and C2"-endo/anti, in the Ba(II)-GMP salt.	Ribose	4-10	5'-nucleotidase, cytosolic II	Homo sapiens	154-157
1297346-6	1992	These differences are most probably due to the specificity or number of ADP-ribose groups added to the histones by the endogenous or exogenous poly(ADP-ribose) polymerase.	Ribose	76-82	poly (ADP-ribose) polymerase family, member 1	Mus musculus	143-170
1351296-1	1992	Guanine nucleotides modified by acetylation of the ribose moiety with the small fluorophore N-methylanthranilic acid(mant) have been shown to bind to p21 ras with similar equilibrium and kinetic rate constants as the parent nucleotides.	Ribose	51-57	H3 histone pseudogene 16	Homo sapiens	150-153
1313365-15	1992	Studies with the mutant cell lines indicate that the toxin and the cellular transferase, however, recognize different determinants at the ADP-ribose acceptor site in EF-2.	Ribose	142-148	elongation factor 2	Cricetulus griseus	166-170
1326282-4	1992	The ribose moiety of pGp adopts a C3"-endo pucker form when bound to the enzyme and the glycosyl torsion angle will be in -syn range as 5"-GMP in the RNase T1-5"-GMP complex.	Ribose	4-10	phosphoglycolate phosphatase	Homo sapiens	21-24
1540622-4	1992	The fluorophore could be synthesized by incubation of bovine serum albumin (BSA) with ribose, but not with glucose or fructose.	Ribose	86-92	albumin	Homo sapiens	61-74
1740142-4	1992	The stoichiometry of ADP-ribose incorporation into these actins was 1.2 mol, 1.0 mol and 2.0 mol ADP-ribose/mol of beta/gamma-actin, alpha-actin and gamma-actin, respectively.	Ribose	25-31	actin, beta	Gallus gallus	115-131
1740142-4	1992	The stoichiometry of ADP-ribose incorporation into these actins was 1.2 mol, 1.0 mol and 2.0 mol ADP-ribose/mol of beta/gamma-actin, alpha-actin and gamma-actin, respectively.	Ribose	25-31	actin, alpha 2, smooth muscle, aorta	Gallus gallus	133-144
1740142-4	1992	The stoichiometry of ADP-ribose incorporation into these actins was 1.2 mol, 1.0 mol and 2.0 mol ADP-ribose/mol of beta/gamma-actin, alpha-actin and gamma-actin, respectively.	Ribose	25-31	actin, gamma 2, smooth muscle, enteric	Gallus gallus	120-131
1930240-0	1991	Localization of an endogenous ADP-ribose acceptor, p33, in polymorphonuclear cell granules in chicken liver interlobular connective tissue.	Ribose	34-40	leukocyte cell derived chemotaxin 2	Gallus gallus	51-54
1901925-0	1991	Serum levels of glucose, insulin, and C-peptide during long-term D-ribose administration in man.	Ribose	65-73	insulin	Homo sapiens	38-47
1993675-10	1991	These studies indicate that (i) rS1, purified from Escherichia coli, possesses biochemical properties similar to S1 subunit purified from pertussis toxin, (ii) amino acids 1-180 of the S1 subunit contain residues required for NAD binding, N-glycosidic cleavage, and transfer of ADP-ribose to transducin, and (iii) residues between 181 and 219 of the S1 subunit are required for efficient ADP-ribosyltransferase activity.	Ribose	282-288	retinoschisin 1	Rattus norvegicus	33-35
2405906-7	1990	In solution, the p21-bound GDP.Mg2+ has an anti conformation, and the phenyl ring of Phe28 is close to the ribose of the bound GDP.Mg2+.	Ribose	107-113	H3 histone pseudogene 16	Homo sapiens	17-20
2108672-1	1990	Adenosine Diphosphoribosyl Transferase is a eucaryotic nuclear protein that catalyses the transfer of ADP-ribose moiety of NAD+ to itself and other cellular proteins.	Ribose	106-112	poly(ADP-ribose) polymerase 1	Homo sapiens	0-38
2172924-14	1990	p62 crosslinking was efficiently competed by a DNA oligonucleotide having the same sequence as the 61 nt RNA, showing that p62 requires neither ribose 2" OH groups nor uracil bases for its interaction with the polypyrimidine tract.	Ribose	144-150	nucleoporin 62	Homo sapiens	123-126
2105215-14	1990	Although the inhibitory spectrum of CK-1 by the various analogues is reminiscent of that observed with CK-2, a remarkable difference is revealed by 5"-phosphorylation of ribose which increases the Ki with CK-2 while decreasing that with CK-1.	Ribose	170-176	Calcium-dependent protein kinase 6	Zea mays	205-209
34647721-4	2021	We observe divergent ADP-ribosylation dynamics for the catalytic domains of PARPs 14 and 15, with PARP15 modifying more sites on itself (+3-4 ADP-ribose) than the closely related PARP14 protein (+1-2 ADP-ribose)-despite similar numbers of potential modification sites.	Ribose	204-210	poly(ADP-ribose) polymerase 1	Homo sapiens	76-81
33940558-3	2021	In response to DNA strand breaks, PARP1 covalently attaches ADP-ribose moieties to arginine, glutamate, aspartate, cysteine, lysine, and serine acceptor sites on both itself and other proteins.	Ribose	64-70	poly(ADP-ribose) polymerase 1	Homo sapiens	34-39
34601015-0	2022	Comparison of bovine serum albumin glycation by ribose and fructose in vitro and in vivo.	Ribose	48-54	albumin	Homo sapiens	21-34
34949666-1	2022	The regulation of poly(ADP-ribose) polymerase, the enzyme responsible for the synthesis of homopolymer ADP-ribose chains on nuclear proteins, has been extensively studied over the last decades for its involvement in tumorigenesis processes.	Ribose	107-113	Poly-(ADP-ribose) polymerase	Drosophila melanogaster	18-45
34647721-4	2021	We observe divergent ADP-ribosylation dynamics for the catalytic domains of PARPs 14 and 15, with PARP15 modifying more sites on itself (+3-4 ADP-ribose) than the closely related PARP14 protein (+1-2 ADP-ribose)-despite similar numbers of potential modification sites.	Ribose	204-210	poly(ADP-ribose) polymerase family member 15	Homo sapiens	98-104
34641382-0	2021	Identification of the Protein Glycation Sites in Human Myoglobin as Rapidly Induced by d-Ribose.	Ribose	87-95	myoglobin	Homo sapiens	55-64
34706612-8	2021	RESULTS: We found ribose and riboflavin-465 nm treatment produces fluorescent AGE quantities which match and/or exceed human fluorescent AGE levels for various tissues, ages, and diseases, without affecting cell viability or metabolism.	Ribose	18-24	renin binding protein	Homo sapiens	78-81
34706612-8	2021	RESULTS: We found ribose and riboflavin-465 nm treatment produces fluorescent AGE quantities which match and/or exceed human fluorescent AGE levels for various tissues, ages, and diseases, without affecting cell viability or metabolism.	Ribose	18-24	renin binding protein	Homo sapiens	137-140
34550682-3	2021	The structure-activity relationship and molecular dynamics simulation studies illustrated that the ribose region of FLT3 could be occupied to help address the obstacle of secondary mutations.	Ribose	99-105	fms related receptor tyrosine kinase 3	Homo sapiens	116-120
34641382-4	2021	This article reports that d-ribose undergoes rapid protein glycation of human myoglobin (HMb) at lysine residues (K34, K87, K56, and K147) on the protein surface, as identified by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) and electrospray ionization tandem mass spectrometry (ESI-MS/MS).	Ribose	26-34	myoglobin	Homo sapiens	78-87
34641382-4	2021	This article reports that d-ribose undergoes rapid protein glycation of human myoglobin (HMb) at lysine residues (K34, K87, K56, and K147) on the protein surface, as identified by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) and electrospray ionization tandem mass spectrometry (ESI-MS/MS).	Ribose	26-34	keratin 34	Homo sapiens	114-117
34504490-1	2021	Mouse T cells express the ecto-ADP-ribosyltransferase ARTC2.2, which can transfer the ADP-ribose group of extracellular nicotinamide adenine dinucleotide (NAD+) to arginine residues of various cell surface proteins thereby influencing their function.	Ribose	90-96	ADP-ribosyltransferase 2a	Mus musculus	54-59
34264286-2	2021	ADP-ribosylated AR is recognized by PARP9/DTX3L, a heterodimeric complex that contains an ADP-ribose reader (PARP9) and a ubiquitin E3 ligase (DTX3L).	Ribose	94-100	androgen receptor	Homo sapiens	16-18
34578418-1	2021	In plants, HEN1-facilitated methylation at 3" end ribose is a critical step of small-RNA (sRNA) biogenesis.	Ribose	50-56	nescient helix-loop-helix 1	Homo sapiens	11-15
34321462-5	2021	Structural analysis of ARH3 in complex with dimeric ADP-ribose as well as an ADP-ribosylated peptide reveal the molecular basis for the hydrolysis of linear and terminal ADP-ribose linkages.	Ribose	174-180	ADP-ribosylserine hydrolase	Homo sapiens	23-27
34264286-2	2021	ADP-ribosylated AR is recognized by PARP9/DTX3L, a heterodimeric complex that contains an ADP-ribose reader (PARP9) and a ubiquitin E3 ligase (DTX3L).	Ribose	94-100	poly(ADP-ribose) polymerase family member 9	Homo sapiens	36-41
34264286-2	2021	ADP-ribosylated AR is recognized by PARP9/DTX3L, a heterodimeric complex that contains an ADP-ribose reader (PARP9) and a ubiquitin E3 ligase (DTX3L).	Ribose	94-100	deltex E3 ubiquitin ligase 3L	Homo sapiens	42-47
34264286-2	2021	ADP-ribosylated AR is recognized by PARP9/DTX3L, a heterodimeric complex that contains an ADP-ribose reader (PARP9) and a ubiquitin E3 ligase (DTX3L).	Ribose	94-100	poly(ADP-ribose) polymerase family member 9	Homo sapiens	109-114
35622909-2	2022	Here, we determined neutron and x-ray crystal structures of the SARS-CoV-2 NSP3 macrodomain using multiple crystal forms, temperatures, and pHs, across the apo and ADP-ribose-bound states.	Ribose	168-174	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	75-79
34384295-4	2022	In contrast to other ancient nucleotide binding domains with the alphabetaalpha sandwich architecture, such as P-loop NTPases, the HUP"s most conserved feature is not phosphate binding, but rather ribose binding by backbone interactions to the tips of beta1 and/or beta4.	Ribose	197-203	BCL2 related protein A1	Homo sapiens	252-257
34384295-4	2022	In contrast to other ancient nucleotide binding domains with the alphabetaalpha sandwich architecture, such as P-loop NTPases, the HUP"s most conserved feature is not phosphate binding, but rather ribose binding by backbone interactions to the tips of beta1 and/or beta4.	Ribose	197-203	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	265-270
34220199-10	2021	The capping consists of adding GMP and a methylation mark, called cap 0 and additionally adding a methyl group to the terminal ribose called cap1.	Ribose	127-133	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	141-145
35362650-3	2022	The first module is to culture E. coli MG1655   tktA   tktB   ptsG to metabolize xylose to generate D -ribose in the medium.	Ribose	100-109	transketolase 2	Escherichia coli str. K-12 substr. MG1655	55-59
2528453-2	1989	These ATP analogues can be classified into two conformations, i.e. syn and anti forms with respect to the N-glycosidic bond between adenine and ribose groups of ATP.	Ribose	144-150	synemin	Homo sapiens	67-70
35362650-6	2022	Finally, 10 mL optimal biocascade reaction generated NMN with good yield of 84% from 1 mM D -ribose supplied from the supernatant of E. coli MG1655   tktA   tktB   ptsG .	Ribose	90-99	transketolase 2	Escherichia coli str. K-12 substr. MG1655	157-161
35262075-6	2022	We identified 5 compounds amongst 3 chemotypes that inhibit SARS-CoV-2 Mac1-ADP-ribose binding in multiple assays with IC 50 values less than 100 micro M, inhibit ADP-ribosylhydrolase activity, and have evidence of direct Mac1 binding.	Ribose	80-86	integrin subunit alpha M	Homo sapiens	71-75
35262075-6	2022	We identified 5 compounds amongst 3 chemotypes that inhibit SARS-CoV-2 Mac1-ADP-ribose binding in multiple assays with IC 50 values less than 100 micro M, inhibit ADP-ribosylhydrolase activity, and have evidence of direct Mac1 binding.	Ribose	80-86	integrin subunit alpha M	Homo sapiens	222-226
35080883-5	2022	X-ray structures of hCD73 with two inhibitors indicated a ribose ring conformational adaptation, and the benzyloxyimino group (E configuration) binds to the same region (between the C-terminal and N-terminal domains) as N4-benzyl groups in adenine inhibitors.	Ribose	58-64	5'-nucleotidase ecto	Homo sapiens	20-25
35169801-2	2022	Here, we determined neutron and X-ray crystal structures of the SARS-CoV-2 NSP3 macrodomain using multiple crystal forms, temperatures, and pHs, across the apo and ADP-ribose-bound states.	Ribose	168-174	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	75-79
35425333-6	2022	The bulky moieties (hydroxyl or fluorated phenyl moieties) added to the 2" position of the ribose ring positively impacted the binding affinity to RdRp.	Ribose	91-97	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	147-151
35095818-3	2021	The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation.	Ribose	170-176	poly(ADP-ribose) polymerase 1	Homo sapiens	4-34
35095818-3	2021	The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation.	Ribose	170-176	poly(ADP-ribose) polymerase 1	Homo sapiens	36-41
35095818-3	2021	The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation.	Ribose	170-176	poly(ADP-ribose) polymerase 1	Homo sapiens	56-102
35095818-3	2021	The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation.	Ribose	170-176	poly(ADP-ribose) polymerase 1	Homo sapiens	104-109
35503748-1	2022	Inhibition of RNA-dependent RNA polymerase (RdRp) by nucleotide analogues with ribose modification provides a promising antiviral strategy for the treatment of SARS-CoV-2.	Ribose	79-85	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	44-48
35566069-4	2022	It adopts a novel mechanism to promote SIRT1 activity by covalently bonding to the anomeric C1" carbon of the ribose ring in OAADPr.	Ribose	110-116	sirtuin 1	Homo sapiens	39-44
35566069-6	2022	The longer distance between the anomeric C1" carbon of the ribose ring in OAADPr and Arg274 of SIRT1 (a conserved residue among sirtuins) than that between the anomeric C1" carbon in OAADPr and the Arg of SIRT2, SIRT3, SIRT5, and SIRT6, should be responsible for the high selectivity of CWR for SIRT1.	Ribose	59-65	sirtuin 1	Homo sapiens	95-100
35566069-6	2022	The longer distance between the anomeric C1" carbon of the ribose ring in OAADPr and Arg274 of SIRT1 (a conserved residue among sirtuins) than that between the anomeric C1" carbon in OAADPr and the Arg of SIRT2, SIRT3, SIRT5, and SIRT6, should be responsible for the high selectivity of CWR for SIRT1.	Ribose	59-65	sirtuin 2	Homo sapiens	205-210
35566069-6	2022	The longer distance between the anomeric C1" carbon of the ribose ring in OAADPr and Arg274 of SIRT1 (a conserved residue among sirtuins) than that between the anomeric C1" carbon in OAADPr and the Arg of SIRT2, SIRT3, SIRT5, and SIRT6, should be responsible for the high selectivity of CWR for SIRT1.	Ribose	59-65	sirtuin 3	Homo sapiens	212-217
35566069-6	2022	The longer distance between the anomeric C1" carbon of the ribose ring in OAADPr and Arg274 of SIRT1 (a conserved residue among sirtuins) than that between the anomeric C1" carbon in OAADPr and the Arg of SIRT2, SIRT3, SIRT5, and SIRT6, should be responsible for the high selectivity of CWR for SIRT1.	Ribose	59-65	sirtuin 5	Homo sapiens	219-224
35566069-6	2022	The longer distance between the anomeric C1" carbon of the ribose ring in OAADPr and Arg274 of SIRT1 (a conserved residue among sirtuins) than that between the anomeric C1" carbon in OAADPr and the Arg of SIRT2, SIRT3, SIRT5, and SIRT6, should be responsible for the high selectivity of CWR for SIRT1.	Ribose	59-65	sirtuin 6	Homo sapiens	230-235
35566069-6	2022	The longer distance between the anomeric C1" carbon of the ribose ring in OAADPr and Arg274 of SIRT1 (a conserved residue among sirtuins) than that between the anomeric C1" carbon in OAADPr and the Arg of SIRT2, SIRT3, SIRT5, and SIRT6, should be responsible for the high selectivity of CWR for SIRT1.	Ribose	59-65	sirtuin 1	Homo sapiens	295-300
35240418-4	2022	Molecular docking of 10o to the ATP-binding site of Chk1 kinase domain indicated the existence of polar interactions between 10o and the ATP-ribose-binding residues of Chk1.	Ribose	141-147	checkpoint kinase 1	Mus musculus	52-56
35240418-4	2022	Molecular docking of 10o to the ATP-binding site of Chk1 kinase domain indicated the existence of polar interactions between 10o and the ATP-ribose-binding residues of Chk1.	Ribose	141-147	checkpoint kinase 1	Mus musculus	168-172
2544579-1	1989	Periodate-oxidized adenosine triphosphate (o-ATP), a ribose ring-opened dialdehyde derivative of ATP, reacts specifically with human deoxyhemoglobin to give a single major covalently modified product after reduction with sodium borohydride.	Ribose	53-59	solute carrier organic anion transporter family member 1A2	Homo sapiens	0-48
2493263-3	1989	Results show that in normal adult testis a major acceptor protein for poly(ADP-ribose) in HClO4 extracts is the tissue-specific histone, H1t.	Ribose	79-86	H1.6 linker histone, cluster member	Rattus norvegicus	137-140
3378831-0	1988	Antibody to poly(ADP-ribose) as a predictor of obstetric complications in autoimmune MRL/Mp-lpr/lpr mice: basis for its application to pregnant patients with systemic lupus erythematosus.	Ribose	20-27	Fas (TNF receptor superfamily member 6)	Mus musculus	85-99
16666121-7	1988	In fact, ferricyanide reduction is accompanied by a marked decrease of the incorporation into RNA ribose of C-1 as compared with C-2 of [(14)C]glucose.	Ribose	98-104	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	108-111
2920832-0	1989	GTP interacts through its ribose and phosphate moieties with different subunits of the eukaryotic initiation factor eIF-2.	Ribose	26-32	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	116-121
2920832-2	1989	In the present study a new GTP derivative carrying the photoreactive group at the ribose moiety of GTP was applied for affinity labeling of eIF-2 in different initiation complexes.	Ribose	82-88	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	140-145
3346227-2	1988	Diphtheria toxin and Pseudomonas exotoxin A catalyze the transfer of an ADP-ribose residue from NAD to diphthamide, causing the inactivation of EF-2.	Ribose	76-82	elongation factor 2	Cricetulus griseus	144-148
3087946-1	1986	The Trg transducer mediates chemotactic response to galactose and ribose by interacting, respectively, with sugar-occupied galactose- and ribose-binding proteins.	Ribose	66-72	T cell receptor gamma locus	Homo sapiens	4-7
2442198-1	1987	The chromatin-bound enzyme poly(ADP-ribose) polymerase (ADPRP) is strongly stimulated by DNA with single- or double-stranded breaks, and transfers the ADP-ribose moiety of NAD to nuclear proteins.	Ribose	36-42	poly(ADP-ribose) polymerase 1	Homo sapiens	56-61
3470439-6	1987	These data reveal that there is a rigid structural requirement for binding of the ribose portion of adenosine to both M and P PST that involves the groups on both the 3" and 5" positions.	Ribose	82-88	sulfotransferase family 1A member 1	Homo sapiens	126-129
3529502-5	1986	Among monosaccharides, 2-deoxy-D-ribose, D-galactosamine, L-fucose, N-acetylneuraminic acid and D-ribose decreased insulin release and had no effect on insulin release by D-glucose.	Ribose	31-39	insulin	Homo sapiens	115-122
3699150-4	1986	Histones Hl and H2B were the best ADP-ribose acceptors.	Ribose	38-44	histone cluster 1, H2bg	Rattus norvegicus	16-19
2956659-1	1987	The single-stranded (SS) DNA-dependent ATP hydrolysis at pH 7.5 and 6.2 and the double-stranded (DS) DNA-dependent ATP hydrolysis at pH 6.2 by recA protein (no reaction was detectable at pH 7.5) were found to be inhibited competitively by ribose-modified analogs of ATP, 3"-0-anthraniloyl-ATP (Ant-ATP) and 3"-0-(N-methylanthraniloyl)- ATP (Mant-ATP).	Ribose	239-245	RAD51 recombinase	Homo sapiens	143-147
2956659-6	1987	These observations showed that the ATP analogs which have a bulky substituent in the ribose moiety of ATP had strong hydrophobic interactions with the ATP binding site on the recA protein and also contributed to the cooperative effect of ATP.	Ribose	85-91	RAD51 recombinase	Homo sapiens	175-179
3087946-1	1986	The Trg transducer mediates chemotactic response to galactose and ribose by interacting, respectively, with sugar-occupied galactose- and ribose-binding proteins.	Ribose	138-144	T cell receptor gamma locus	Homo sapiens	4-7
3087946-8	1986	However, the single amino acid substitution caused by trg-19 greatly reduced the response to galactose but left unperturbed the response to ribose.	Ribose	140-146	solute carrier family 37 member 4	Homo sapiens	54-60
3087946-10	1986	trg-8 mutants were substantially defective in the response to both galactose and ribose.	Ribose	81-87	BCL2 interacting protein 1	Homo sapiens	0-5
3718700-1	1986	Hydrolysis of protein-bound 32P-labelled poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase shows that there is differential accessibility of poly(ADP-ribosyl)ated proteins in chromatin to poly(ADP-ribose) glycohydrolase.	Ribose	50-56	poly(ADP-ribose) glycohydrolase	Homo sapiens	61-92
3004981-1	1986	The ATP substrate site in the epidermal growth factor (EGF) receptor was mapped by using a series of 26 ATP derivatives with modifications at the base, ribose or triphosphate moiety.	Ribose	152-158	epidermal growth factor receptor	Homo sapiens	30-68
3718700-1	1986	Hydrolysis of protein-bound 32P-labelled poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase shows that there is differential accessibility of poly(ADP-ribosyl)ated proteins in chromatin to poly(ADP-ribose) glycohydrolase.	Ribose	50-56	poly(ADP-ribose) glycohydrolase	Homo sapiens	190-221
3019327-2	1986	The ESR spectra demonstrate that SL-poly(U) with a modification of 1 spin label per 20 ribose residues binds to 80S ribosomes as well as to 40S subunits in a 1:1 stoichiometry at 12 mM MgCl2.	Ribose	87-93	spindlin 1	Rattus norvegicus	69-73
4062947-3	1985	Polyacrylamide gel electrophoresis reveals that the core histones H2B, A24 and H3d serve as major poly ADP-ribose acceptors.	Ribose	107-113	CD164 antigen	Mus musculus	71-74
3894350-6	1985	The interaction of guanosine nucleotides with IF-2 requires an H bond donor (or acceptor) group at position C-2 of the purine and involves the beta- and/or gamma-phosphate of the nucleotide while the ribose 2"-OH group or the integrity of the furan ring are less critical.	Ribose	200-206	eukaryotic translation initiation factor 5B	Homo sapiens	46-50
4003756-5	1985	When dimeric bovine seminal RNase was monomerized in advance by treatment with dithiothreitol and urea, the enzyme lost ADP-ribose-accepting ability in spite of a significant residual enzyme activity.	Ribose	124-130	seminal ribonuclease	Bos taurus	20-33
6498817-7	1984	All five compounds have the syn-conformational relationship between the sugar (ribose or 2"-deoxyribose) and the base (adenine), in contrast to the anti arrangement in B-DNA and in nonalkylated nucleosides.	Ribose	79-85	synemin	Homo sapiens	28-31
6320900-3	1984	Glycosylation with glucose, idose or ribose blocks the interaction of the lipoprotein with the high-affinity LDL receptor on cultured fibroblast membranes and delays its clearance from the plasma of rabbits.	Ribose	37-43	low-density lipoprotein receptor	Oryctolagus cuniculus	109-121
6238020-0	1984	Affinity labeling of the myosin ATPase with ribose-modified fluorescent nucleotides and vanadate.	Ribose	44-50	myosin heavy chain 14	Homo sapiens	25-31
6238020-1	1984	Ribose-modified fluorescent nucleotide analogs, 3"-O-anthraniloyl and 3"-O-(N-methylanthraniloyl) derivatives of AT(D)P, dAT(D)P, CT(D)P, UT(D)P, IT(D)P, and GT(D)P, were synthesized for use as substrates and affinity labels for the myosin ATPase [Hiratsuka, T. (1983) Biochim.	Ribose	0-6	Dopamine transporter	Drosophila melanogaster	121-124
6238020-1	1984	Ribose-modified fluorescent nucleotide analogs, 3"-O-anthraniloyl and 3"-O-(N-methylanthraniloyl) derivatives of AT(D)P, dAT(D)P, CT(D)P, UT(D)P, IT(D)P, and GT(D)P, were synthesized for use as substrates and affinity labels for the myosin ATPase [Hiratsuka, T. (1983) Biochim.	Ribose	0-6	myosin heavy chain 14	Homo sapiens	233-239
6237610-1	1984	The single-stranded, DNA-dependent ATPase activity of purified recA protein was found to be inhibited competitively by ribose-modified analogs of ATP, 3"-O-anthraniloyl-ATP (Ant-ATP), and 3"-O-(N-methylanthraniloyl)-ATP (Mant-ATP).	Ribose	119-125	dynein axonemal heavy chain 8	Homo sapiens	35-41
6237610-1	1984	The single-stranded, DNA-dependent ATPase activity of purified recA protein was found to be inhibited competitively by ribose-modified analogs of ATP, 3"-O-anthraniloyl-ATP (Ant-ATP), and 3"-O-(N-methylanthraniloyl)-ATP (Mant-ATP).	Ribose	119-125	RAD51 recombinase	Homo sapiens	63-67
6238021-1	1984	The active site of the myosin subfragment-1 ATPase was affinity-labeled with ribose-modified fluorescent analogs of ADP, dADP, CDP, UDP, IDP, and GDP in combination with vanadate, forming a stable myosin-nucleoside diphosphate-vanadate complex that is analogous to the normal myosin-ADP-Pi intermediate [Hiratsuka, T. (1984) J. Biochem.	Ribose	77-83	myosin heavy chain 14	Homo sapiens	23-29
6238021-1	1984	The active site of the myosin subfragment-1 ATPase was affinity-labeled with ribose-modified fluorescent analogs of ADP, dADP, CDP, UDP, IDP, and GDP in combination with vanadate, forming a stable myosin-nucleoside diphosphate-vanadate complex that is analogous to the normal myosin-ADP-Pi intermediate [Hiratsuka, T. (1984) J. Biochem.	Ribose	77-83	myosin heavy chain 14	Homo sapiens	197-203
6238021-1	1984	The active site of the myosin subfragment-1 ATPase was affinity-labeled with ribose-modified fluorescent analogs of ADP, dADP, CDP, UDP, IDP, and GDP in combination with vanadate, forming a stable myosin-nucleoside diphosphate-vanadate complex that is analogous to the normal myosin-ADP-Pi intermediate [Hiratsuka, T. (1984) J. Biochem.	Ribose	77-83	myosin heavy chain 14	Homo sapiens	197-203
6423640-8	1984	The elevated PPRibP content of HPRT-deficient cells reflects the efficient, unilateral reutilization of the ribose moiety of purine ribonucleotides and is not a cause of purine overproduction.	Ribose	108-114	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	13-19
6423640-8	1984	The elevated PPRibP content of HPRT-deficient cells reflects the efficient, unilateral reutilization of the ribose moiety of purine ribonucleotides and is not a cause of purine overproduction.	Ribose	108-114	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	31-35
6317693-6	1983	The rapid loss of (ADP-ribose)n from HMG 14 and 17 occurred in the same time frame as the induction of mouse mammary tumor virus RNA synthesis by glucocorticoids in these cells (Young, H. A., Shih, T. Y., Scolnick, E. M., and Parks, W. P. (1977) J. Virol.	Ribose	23-29	high mobility group nucleosome binding domain 1	Homo sapiens	37-43
6227622-0	1983	Alterations in the structure of the ribose moiety of ATP reduce its effectiveness as a substrate for the sarcoplasmic reticulum ATPase.	Ribose	36-42	dynein axonemal heavy chain 8	Homo sapiens	128-134
6227622-1	1983	The substrate specificity of the calcium ATPase of isolated sarcoplasmic reticulum vesicles was examined using a series of ribose-modified ATP analogs.	Ribose	123-129	dynein axonemal heavy chain 8	Homo sapiens	41-47
6315008-9	1983	The ADP-ribosylated A1 was stable at low pH, and on cleavage with BrCN, the ADP-ribose moiety was found associated with peptide Cn I, the COOH-terminal fragment of A1 subunit.	Ribose	80-86	5'-nucleotidase, cytosolic IA	Homo sapiens	128-132
6315008-10	1983	On further fragmentation with cathepsin D, a dodecapeptide containing ADP-ribose moiety was isolated whose structure was determined as: Asp-Glu-Glu-Leu-His-Arg-Gly-Tyr-Arg*-Asp-Arg-Tyr.	Ribose	74-80	cathepsin D	Homo sapiens	30-41
6324859-8	1984	The substitutions of the 2"- or 3"-hydrogen for hydroxyl groups in the ribose moiety of this compound slightly affected its suitability as substrate for myokinase but had drastic effect in the case of adenylate deaminase.	Ribose	71-77	adenylate kinase 1	Homo sapiens	153-162
6871163-2	1983	The results demonstrate that the conformation of the nicotinamide-ribose bond is anti for dehydrogenases with A stereospecificity and syn for dehydrogenases with B stereospecificity.	Ribose	66-72	synemin	Homo sapiens	134-137
6782097-4	1981	Poly(ADP-ribose) glycohydrolase, which specifically hydrolyzes the ribose-ribose bonds of poly(ADP-ribose), also cleaves the ribose-ribose-ribose bonds at the site of branching.	Ribose	67-73	poly(ADP-ribose) glycohydrolase	Homo sapiens	0-31
6654830-5	1983	ADP-ribosylation of elongation factor 2 (EF-2) catalyzed by diphtheria toxin was measured in cell-free extracts from the parent cells and 17 DTr cells, including 6 spontaneous DTr cells and 11 DTr cells induced by mutagens; the numbers of ADP-ribose molecules transfer to EF-2 in extracts of mutant cells were less than 1% of that in extract of the parent cells.	Ribose	243-249	elongation factor 2	Cricetulus griseus	20-39
6654830-5	1983	ADP-ribosylation of elongation factor 2 (EF-2) catalyzed by diphtheria toxin was measured in cell-free extracts from the parent cells and 17 DTr cells, including 6 spontaneous DTr cells and 11 DTr cells induced by mutagens; the numbers of ADP-ribose molecules transfer to EF-2 in extracts of mutant cells were less than 1% of that in extract of the parent cells.	Ribose	243-249	elongation factor 2	Cricetulus griseus	41-45
6288103-1	1982	Ribokinase, the first enzyme in ribose catabolism, is altered in its expression in ribose-utilizing Novikoff hepatoma variants.	Ribose	32-38	ribokinase	Rattus norvegicus	0-10
6288103-1	1982	Ribokinase, the first enzyme in ribose catabolism, is altered in its expression in ribose-utilizing Novikoff hepatoma variants.	Ribose	83-89	ribokinase	Rattus norvegicus	0-10
6288103-2	1982	90% of the variants selected for their ability to use D-ribose as a sole carbon source show a change in ribokinase activity.	Ribose	54-62	ribokinase	Rattus norvegicus	104-114
6782097-4	1981	Poly(ADP-ribose) glycohydrolase, which specifically hydrolyzes the ribose-ribose bonds of poly(ADP-ribose), also cleaves the ribose-ribose-ribose bonds at the site of branching.	Ribose	67-73	poly(ADP-ribose) glycohydrolase	Homo sapiens	0-31
6782097-4	1981	Poly(ADP-ribose) glycohydrolase, which specifically hydrolyzes the ribose-ribose bonds of poly(ADP-ribose), also cleaves the ribose-ribose-ribose bonds at the site of branching.	Ribose	67-73	poly(ADP-ribose) glycohydrolase	Homo sapiens	0-31
6160908-3	1981	RNA incorporation of 5-aza-Cyd increased from 97.5 +/- 3.4 pmol 5-aza-Cyd per microgram D-ribose in control cells to 299.2 +/- 4.2 pmol 5-aza-Cyd per microgram D-ribose in PALA-treated cells; a smaller increment in DNA incorporation of 5-aza-Cyd was also noted.	Ribose	88-96	cytochrome b-245, beta polypeptide	Mus musculus	27-30
6160908-3	1981	RNA incorporation of 5-aza-Cyd increased from 97.5 +/- 3.4 pmol 5-aza-Cyd per microgram D-ribose in control cells to 299.2 +/- 4.2 pmol 5-aza-Cyd per microgram D-ribose in PALA-treated cells; a smaller increment in DNA incorporation of 5-aza-Cyd was also noted.	Ribose	88-96	cytochrome b-245, beta polypeptide	Mus musculus	70-73
6160908-3	1981	RNA incorporation of 5-aza-Cyd increased from 97.5 +/- 3.4 pmol 5-aza-Cyd per microgram D-ribose in control cells to 299.2 +/- 4.2 pmol 5-aza-Cyd per microgram D-ribose in PALA-treated cells; a smaller increment in DNA incorporation of 5-aza-Cyd was also noted.	Ribose	88-96	cytochrome b-245, beta polypeptide	Mus musculus	70-73
6160908-3	1981	RNA incorporation of 5-aza-Cyd increased from 97.5 +/- 3.4 pmol 5-aza-Cyd per microgram D-ribose in control cells to 299.2 +/- 4.2 pmol 5-aza-Cyd per microgram D-ribose in PALA-treated cells; a smaller increment in DNA incorporation of 5-aza-Cyd was also noted.	Ribose	88-96	cytochrome b-245, beta polypeptide	Mus musculus	70-73
6160908-3	1981	RNA incorporation of 5-aza-Cyd increased from 97.5 +/- 3.4 pmol 5-aza-Cyd per microgram D-ribose in control cells to 299.2 +/- 4.2 pmol 5-aza-Cyd per microgram D-ribose in PALA-treated cells; a smaller increment in DNA incorporation of 5-aza-Cyd was also noted.	Ribose	160-168	cytochrome b-245, beta polypeptide	Mus musculus	27-30
6256803-2	1980	AC4"-centered radical in the ribose moiety of uridine-5"-phosphate single crystals.	Ribose	29-35	adenylate cyclase 4	Homo sapiens	0-3
6257855-3	1981	The isolated TSH A and B subunits were tested for their ADP-ribose acceptor activity.	Ribose	60-66	glycoprotein hormones, alpha polypeptide	Homo sapiens	13-24
6257855-4	1981	The TSH A subunit showed fourfold greater ADP-ribose acceptor activity than the TSH B subunit.	Ribose	46-52	glycoprotein hormones, alpha polypeptide	Homo sapiens	4-9
6928655-1	1980	We have identified two types of mutants of Chinese hamster ovary cells in which the unique ADP-ribose attachment site in elongation factor 2 (EF-2) is altered, thereby rendering them resistant to diphtheria and Pseudomonas toxins (TOXR).	Ribose	95-101	elongation factor 2	Cricetulus griseus	121-140
6993458-4	1980	Electrophoretic analysis of sulfur-labeled proteins and methyl-labeled proteins from trg mutants, which lost the ability of chemotaxis only towards ribose, galactose and their analogs, showed that the product of trg gene was another methyl-accepting protein i.e. a methyl-accepting chemotaxis protein for ribose and galactose (trg-MCP).	Ribose	148-154	mcp	Escherichia coli	331-334
6928655-1	1980	We have identified two types of mutants of Chinese hamster ovary cells in which the unique ADP-ribose attachment site in elongation factor 2 (EF-2) is altered, thereby rendering them resistant to diphtheria and Pseudomonas toxins (TOXR).	Ribose	95-101	elongation factor 2	Cricetulus griseus	142-146
375029-1	1979	From a collection of 8,000 transposon-insertion mutants of Escherichia coli K12 we identified two mutations, trg-1::Tn5 and trg-2::Tn10, that simultaneously eliminate chemotactic response to ribose and galactose, two attractants recognized by independent receptors.	Ribose	191-197	T cell receptor gamma locus	Homo sapiens	109-112
375029-1	1979	From a collection of 8,000 transposon-insertion mutants of Escherichia coli K12 we identified two mutations, trg-1::Tn5 and trg-2::Tn10, that simultaneously eliminate chemotactic response to ribose and galactose, two attractants recognized by independent receptors.	Ribose	191-197	T cell receptor gamma locus	Homo sapiens	124-127
640718-1	1978	Antibodies to poly(ADP-ribose) were produced in C3H/He mice by injection of poly(ADP-ribose) in Freund"s incomplete adjuvant or its complexes with methylated bovine serum albumin in Freund"s incomplete adjuvant.	Ribose	23-29	albumin	Mus musculus	165-178
728538-5	1978	Changes in carbon-13 chemical shifts fro ribose C-5" (downfield), C-2" C-3", and C-4" (upfield) and for adenine C-6 and C-8 (upfield) support this model.	Ribose	41-47	complement C5	Homo sapiens	48-51
729572-3	1978	Most (ADP-ribose)n-histone H1 conjugates formed in vivo carried single ADP-ribose units, less than one fourth of the total ADP-ribose residues being in the form of oligomeric or polymeric chains.	Ribose	10-16	H1.0 linker histone	Homo sapiens	19-29
729572-3	1978	Most (ADP-ribose)n-histone H1 conjugates formed in vivo carried single ADP-ribose units, less than one fourth of the total ADP-ribose residues being in the form of oligomeric or polymeric chains.	Ribose	75-81	H1.0 linker histone	Homo sapiens	19-29
729572-7	1978	By contrast, isolated HeLa nuclei formed ADP-ribosylated histone H1 which contained predominantly polymeric ADP-ribose residues.	Ribose	112-118	H1.0 linker histone	Homo sapiens	57-67
729572-9	1978	A comparison with the ADP-ribosylated non-histone proteins indicated that histone H1 formed in vivo carried less than 2.5% of the total protein-bound ADP-ribose residues and less than 1% of the protein-bound ADP-ribose synthesized in vitro.	Ribose	154-160	H1.0 linker histone	Homo sapiens	74-84
27211-2	1978	Chromatographic and UV spectral data on these and related products support a mechanism for NADH acid degradation involving hydroxy addition at the nicotinamide C-6 followed by cyclization of the ring and the adjacent ribose moiety.	Ribose	217-223	complement C6	Homo sapiens	160-163
209007-2	1978	It was observed that substitution at N1 or N2 with a bulky alkyl group or cyclic phosphorylation of the ribose moiety made formycin resistant to adenosine deaminase.	Ribose	104-110	adenosine deaminase	Homo sapiens	145-164
562185-0	1977	Influence of substituent ribose on transition state affinity in reactions catalyzed by adenosine deaminase.	Ribose	25-31	adenosine deaminase	Bos taurus	87-106
348199-4	1978	D-Ribose, which enhanced proinsulin biosynthesis at 0.3 and 0.6 mM but not at 5mM in rat pancreatic islets [jain & Logothetopoulos (1977) Endocrinology 100, 923-927], produced no secretory signals in rat islets and was without any effect on proinsulin biosynthesis and insulin secretion in mouse islets.	Ribose	0-8	insulin II	Mus musculus	25-35
348199-4	1978	D-Ribose, which enhanced proinsulin biosynthesis at 0.3 and 0.6 mM but not at 5mM in rat pancreatic islets [jain & Logothetopoulos (1977) Endocrinology 100, 923-927], produced no secretory signals in rat islets and was without any effect on proinsulin biosynthesis and insulin secretion in mouse islets.	Ribose	0-8	insulin II	Mus musculus	245-255
303566-7	1977	These studies corroborate the previously proposed correlations between the N state of the ribose and the anti orientation of the base and between the S state of the ribose and the syn orientation of the base.	Ribose	165-171	synemin	Homo sapiens	180-183
963238-0	1976	Influence of ribose 2"-O-methylation on GpC conformation by classical potential energy calculations.	Ribose	13-19	glycophorin C (Gerbich blood group)	Homo sapiens	40-43
870035-8	1977	Analysis of the ribose coupling data shows that the percentage populations of stacked species vary from dimer to dimer with GpC displaying a maximum of 45% stacked population and UpG about 10%.	Ribose	16-22	glycophorin C (Gerbich blood group)	Homo sapiens	124-127
165189-8	1975	Moreover, the finding that the ribose of m3 2, 2, 7G was oxidized by NaIO4 and reduced by KB3H4 in intact U-2 RNA rules out other linkages involving the 2" and 3" positions.	Ribose	31-37	RNA, U2 small nuclear 4, pseudogene	Homo sapiens	106-109
952873-1	1976	The dialdehyde produced by the periodate cleavage of the ribose moiety of uridine 5"-diphosphate (UDP) has been used as an affinity label for the UDP-galactose/UDP binding site of galactosyltransferase from bovine colostrum.	Ribose	57-63	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	180-201
689031-7	1978	NAD+ immobilized on agarose through the C-8 of the adenine ring is a superior substrate compared with NAD+ linked to agarose via its periodate-oxidized ribose moieties.	Ribose	152-158	homeobox C8	Homo sapiens	40-43
182650-4	1976	The pentose phosphate, or hexose monophosphate oxidation, pathway is a major source of NADPH required for the conversion of carbohydrate to the more reduced lipids and proteins, and also furnishes the ribose and deoxyribose moieties of nucleotides and nucleic acids.	Ribose	201-207	2,4-dienoyl-CoA reductase 1	Homo sapiens	87-92
1234023-0	1975	Conformation of the common purine (beta) ribosides in solution: further evidence for a correlation between N-S state of the ribose moiety and syn-anti equilibrium.	Ribose	124-130	synemin	Homo sapiens	142-145
125961-7	1975	The results support the previously proposed correlation of the S state of the ribose with the syn conformation of the base and of the N state of the ribose with the anti conformation of the base.	Ribose	78-84	synemin	Homo sapiens	94-97
125961-8	1975	Furthermore, it is derived that the gg rotamer is correlated with the S state of the ribose and therefore stabilizes the syn conformation of the base.	Ribose	85-91	synemin	Homo sapiens	121-124
1234023-7	1975	From NOE studies and T1 measurements on the individual protons it is derived that the N, C(3")-endo, form of the ribose is correlated with an anti conformation of the base (Y approximately 210 degrees to 220 degrees) and the S, C(2")-endo, form of the ribose with a syn conformation of the base (Y approximately 30 degrees to 50 degrees).	Ribose	113-119	synemin	Homo sapiens	266-269
1234023-7	1975	From NOE studies and T1 measurements on the individual protons it is derived that the N, C(3")-endo, form of the ribose is correlated with an anti conformation of the base (Y approximately 210 degrees to 220 degrees) and the S, C(2")-endo, form of the ribose with a syn conformation of the base (Y approximately 30 degrees to 50 degrees).	Ribose	252-258	synemin	Homo sapiens	266-269
5257961-3	1969	Interferon-inducing activity is found with a variety of double-stranded helical polynucleotides, provided that all the sugar residues are ribose.	Ribose	138-144	interferon	Gallus gallus	0-11
4440757-0	1974	Indirect mechanism of insulin release from dog pancreas during infusions of D-ribose.	Ribose	76-84	insulin	Canis lupus familiaris	22-29
5391732-0	1969	[Incorporation of P32 into nucleotides of thymus nuclei incubated with ribose and glucose].	Ribose	71-77	inhibitor of growth family member 2	Homo sapiens	18-21
13630887-0	1959	Labeling of glucose, ribose, and deoxyribose by 1- and 2-C14-glycine in regenerating rat liver.	Ribose	21-27	anti-Mullerian hormone receptor type 2	Rattus norvegicus	57-60
5655656-0	1968	The effect of oral and intravenous D-ribose on plasma insulin levels in unanesthetized dogs.	Ribose	35-43	insulin	Canis lupus familiaris	54-61
33159852-5	2021	G6PD also increases nucleotide precursor levels through the production of ribose and NADPH, promoting cell proliferation.	Ribose	74-80	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
33848722-3	2021	Conjugate derived from ribose (6e), which exhibited pronounced HBsAg specific antibody (IgG) titer also shown enhanced CD8+ population indicating superior cell mediated immunity compared to standard adjuvant Pam3CSK4.	Ribose	23-29	CD8a molecule	Homo sapiens	119-122
33513091-7	2021	These findings provide the rationale for testing ribose/ribitol in combination with NAD+ to treat WWS and other diseases associated with FKRP mutations.	Ribose	49-55	fukutin related protein	Homo sapiens	137-141
33510458-5	2021	TIGAR in turn facilitates pentose phosphate pathway flux to produce nicotinamide adenine dinucleotide phosphate (NADPH) and ribose, thereby promoting DNA repair, and reducing intracellular reactive oxygen species.	Ribose	124-130	TP53 induced glycolysis regulatory phosphatase	Rattus norvegicus	0-5
33361598-11	2021	BBR reduces the activity of BACE1 and gamma-secretase induced by D-ribose, and enhances Abeta-degrading enzymes and Neprilysin, and inhibits the expression of Abeta in APP/PS1 mice.	Ribose	65-73	beta-site APP cleaving enzyme 1	Mus musculus	28-33
5764442-0	1969	Stimulation of insulin secretion in the rabbit by D-ribose.	Ribose	50-58	insulin	Oryctolagus cuniculus	15-22
33972410-3	2021	Nsp10/16 heterodimer is responsible for the methylation at the ribose 2"-O position of the first nucleotide.	Ribose	63-69	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	0-8
34011547-3	2021	Currently, most of the information regarding the role of CoV Mac1 during infection is based on a single point mutation of a highly conserved asparagine residue, which makes contact with the distal ribose of ADP-ribose.	Ribose	197-203	integrin subunit beta 2	Homo sapiens	61-65
33989757-8	2021	Serum D-ribose exhibited a positive correlation (P < 0.05) with serum AGEs, RAGE, ox-LDL, and fasting blood glucose, but a negative correlation (P < 0.05) with MoCA score.	Ribose	6-14	advanced glycosylation end-product specific receptor	Homo sapiens	76-80
33788387-11	2021	We found that D-ribose, a RAGE agonist, reverses the protective role of FGF1 in AML12 cells.	Ribose	14-22	advanced glycosylation end product-specific receptor	Mus musculus	26-30
33788387-11	2021	We found that D-ribose, a RAGE agonist, reverses the protective role of FGF1 in AML12 cells.	Ribose	14-22	fibroblast growth factor 1	Mus musculus	72-76
33885187-0	2021	Design and optimizing a new CDP-choline in-vitro multi-enzyme producing process starts from D-ribose.	Ribose	92-100	cut like homeobox 1	Homo sapiens	28-31
33885187-1	2021	OBJECTIVE: This work designs an in vitro multi-enzyme system to produce CDP-choline form D-ribose, and develop an optimization procedure for one-pot multi-enzyme catalytic system.	Ribose	89-97	cut like homeobox 1	Homo sapiens	72-75
33728914-7	2021	The ribose is easily dissociated from the binding site of wild-type RBP and RBPG134R in the cMD simulations starting from the open and open-like forms.	Ribose	4-10	retinol binding protein 4	Homo sapiens	68-71
33668847-5	2021	APT catalyzes the binding of the nucleobase to the ribose moiety, followed by two consecutive phosphorylation reactions by PPK.	Ribose	51-57	adenine phosphoribosyltransferase	Homo sapiens	0-3
33257205-6	2021	The compressive and tensile properties of the kidney ECM were evaluated using an accelerated model of AGE formation by ribose.	Ribose	119-125	renin binding protein	Homo sapiens	102-105
33335166-3	2020	Studying H6PD biological role in breast and lung cancer, here we show that gene silencing of this reticular enzyme decreases cell content of PPP intermediates and D-ribose, to a similar extent as G6PD silencing.	Ribose	163-171	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	9-13
33295875-5	2020	The latter comprises the "Walker B" aspartate that chelates the catalytic metal in P-loop NTPases, or the canonical Rossmann beta2-Asp that binds the cofactor"s ribose moiety.	Ribose	161-167	glycoprotein hormone subunit alpha 2	Homo sapiens	125-130
32898647-3	2020	The features of energy sensing and ADP-ribose transference of SIRT3 have also been reported.	Ribose	39-45	sirtuin 3	Homo sapiens	62-67
33006575-2	2020	MacroD2 is a single-domain protein that contains a deep ADP-ribose-binding groove.	Ribose	60-66	mono-ADP ribosylhydrolase 2	Homo sapiens	0-7
32772827-0	2021	An in vitro approach to unveil the structural alterations in d-ribose induced glycated fibrinogen.	Ribose	61-69	fibrinogen beta chain	Homo sapiens	87-97
32897053-3	2020	Here, we utilize the highly specific recognition of ribose by ribose-binding protein (RBP) to develop a single-protein ribose sensor detectable via a sensitive NMR technique known as hyperpolarized 129Xe chemical exchange saturation transfer (hyper-CEST).	Ribose	52-58	retinol binding protein 4	Homo sapiens	62-84
32897053-3	2020	Here, we utilize the highly specific recognition of ribose by ribose-binding protein (RBP) to develop a single-protein ribose sensor detectable via a sensitive NMR technique known as hyperpolarized 129Xe chemical exchange saturation transfer (hyper-CEST).	Ribose	52-58	retinol binding protein 4	Homo sapiens	86-89
32897053-3	2020	Here, we utilize the highly specific recognition of ribose by ribose-binding protein (RBP) to develop a single-protein ribose sensor detectable via a sensitive NMR technique known as hyperpolarized 129Xe chemical exchange saturation transfer (hyper-CEST).	Ribose	62-68	retinol binding protein 4	Homo sapiens	86-89
32897053-4	2020	We demonstrate that RBP, with a tunable ribose-binding site and further engineered to bind xenon, enables the quantitation of ribose over a wide concentration range (nM to mM).	Ribose	40-46	retinol binding protein 4	Homo sapiens	20-23
32897053-4	2020	We demonstrate that RBP, with a tunable ribose-binding site and further engineered to bind xenon, enables the quantitation of ribose over a wide concentration range (nM to mM).	Ribose	126-132	retinol binding protein 4	Homo sapiens	20-23
32897053-5	2020	Ribose binding induces the RBP "closed" conformation, which slows Xe exchange to a rate detectable by hyper-CEST.	Ribose	0-6	retinol binding protein 4	Homo sapiens	27-30
32157557-8	2020	RPIA methylation supports ROS clearance by enhancing NADPH production and fuels nucleic acid synthesis by increasing ribose supply.	Ribose	117-123	ribose 5-phosphate isomerase A	Homo sapiens	0-4
33005627-6	2020	Poly(ADP-ribose) glycohydrolase (PARG) reverses the action of PARP enzymes, hydrolysing the ribose-ribose bonds present in poly(ADP-ribose).	Ribose	9-15	poly(ADP-ribose) glycohydrolase	Homo sapiens	33-37
33005627-6	2020	Poly(ADP-ribose) glycohydrolase (PARG) reverses the action of PARP enzymes, hydrolysing the ribose-ribose bonds present in poly(ADP-ribose).	Ribose	9-15	poly(ADP-ribose) polymerase 1	Homo sapiens	62-66
33005627-6	2020	Poly(ADP-ribose) glycohydrolase (PARG) reverses the action of PARP enzymes, hydrolysing the ribose-ribose bonds present in poly(ADP-ribose).	Ribose	92-98	poly(ADP-ribose) glycohydrolase	Homo sapiens	0-31
33005627-6	2020	Poly(ADP-ribose) glycohydrolase (PARG) reverses the action of PARP enzymes, hydrolysing the ribose-ribose bonds present in poly(ADP-ribose).	Ribose	92-98	poly(ADP-ribose) glycohydrolase	Homo sapiens	33-37
33005627-6	2020	Poly(ADP-ribose) glycohydrolase (PARG) reverses the action of PARP enzymes, hydrolysing the ribose-ribose bonds present in poly(ADP-ribose).	Ribose	92-98	poly(ADP-ribose) polymerase 1	Homo sapiens	62-66
32772827-5	2021	Therefore, it was designed as an in vitro study to elucidate d-ribose mediated glycative damage suffered by fibrinogen protein at secondary and tertiary structure level.	Ribose	61-69	fibrinogen beta chain	Homo sapiens	108-118
32772827-9	2021	Structural alterations, increased ketoamines, protein carbonyls and HMF contents were reported in d-ribose glycated fibrinogen against their native analogues.	Ribose	98-106	fibrinogen beta chain	Homo sapiens	116-126
32772827-11	2021	Thus, we can conclude that under diabetes induced hyperglycemic state in physiological systems, d-ribose induced fibrinogen glycation might play a crucial role in the onset of micro- and macro-vascular complications, thereby worsen the diabetes associated secondary disorders.	Ribose	96-104	fibrinogen beta chain	Homo sapiens	113-123
31780222-2	2020	The formation kinetics of ARP from glycine-ribose system, 3-deoxyribosone (3-DR) and 1-deoxyribosone (1-DR) were evaluated, and then controlled thermal reaction (CTR) coupled with vacuum dehydration was proposed to improve the ARP yield.	Ribose	35-49	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	26-29
32736689-6	2020	In vitro biochemical assays showed that the ribose moiety of cytidine is required for ligand binding, and structural analyses revealed a conserved catalytic mechanism is adopted by AtCDA1.	Ribose	44-50	cytidine deaminase 1	Arabidopsis thaliana	181-187
32187120-8	2020	Novel A3AR agonists for pain control containing a bicyclic ring system (bicyclo[3.1.0]hexane) in place of ribose were designed and screened using an in vivo phenotypic model, which reflected both pharmacokinetic and pharmacodynamic parameters.	Ribose	106-112	adenosine A3 receptor	Homo sapiens	6-10
32390412-7	2020	Finally, we establish that the known oncoprotein and hexose deglycase, fructosamine 3-kinase (FN3K), recognizes and facilitates the removal of 5-AR glycation adducts in live cells, supporting the dynamic regulation of ribose glycation as well as validating the probe as a new chemical tool to monitor FN3K activity.	Ribose	218-224	fructosamine 3 kinase	Homo sapiens	71-92
32390412-7	2020	Finally, we establish that the known oncoprotein and hexose deglycase, fructosamine 3-kinase (FN3K), recognizes and facilitates the removal of 5-AR glycation adducts in live cells, supporting the dynamic regulation of ribose glycation as well as validating the probe as a new chemical tool to monitor FN3K activity.	Ribose	218-224	fructosamine 3 kinase	Homo sapiens	94-98
32390412-7	2020	Finally, we establish that the known oncoprotein and hexose deglycase, fructosamine 3-kinase (FN3K), recognizes and facilitates the removal of 5-AR glycation adducts in live cells, supporting the dynamic regulation of ribose glycation as well as validating the probe as a new chemical tool to monitor FN3K activity.	Ribose	218-224	fructosamine 3 kinase	Homo sapiens	301-305
32034076-1	2020	PURPOSE: Poly ADP-ribose inhibitors (PARPi) are efficacious in multiple cancers harboring germline (and possibly somatic) BRCA1/2 mutations.	Ribose	18-24	BRCA1 DNA repair associated	Homo sapiens	122-127
32511412-6	2020	SARS-CoV-2, SARS-CoV and MERS-CoV Mac1 exhibit similar structural folds and ADP-ribose binding modes as shown by structural comparison.	Ribose	80-86	integrin subunit alpha M	Homo sapiens	34-38
32397643-2	2020	The nsp16 catalytic subunit of the 2"-O-MTase is unusual in its requirement for a stimulatory subunit (nsp10) to catalyze the ribose 2"-O-methylation of the viral RNA cap.	Ribose	126-132	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	103-108
32169593-2	2020	d-ribose derivative 6f exhibited the greatest inhibitory activity on BChE (IC50 = 6.95 muM), and was the most selective inhibitor of BChE with the IC50 ratio of AChE/BChE was 20.59.	Ribose	0-8	butyrylcholinesterase	Homo sapiens	69-73
32169593-2	2020	d-ribose derivative 6f exhibited the greatest inhibitory activity on BChE (IC50 = 6.95 muM), and was the most selective inhibitor of BChE with the IC50 ratio of AChE/BChE was 20.59.	Ribose	0-8	butyrylcholinesterase	Homo sapiens	133-137
32169593-2	2020	d-ribose derivative 6f exhibited the greatest inhibitory activity on BChE (IC50 = 6.95 muM), and was the most selective inhibitor of BChE with the IC50 ratio of AChE/BChE was 20.59.	Ribose	0-8	acetylcholinesterase (Cartwright blood group)	Homo sapiens	161-165
32169593-2	2020	d-ribose derivative 6f exhibited the greatest inhibitory activity on BChE (IC50 = 6.95 muM), and was the most selective inhibitor of BChE with the IC50 ratio of AChE/BChE was 20.59.	Ribose	0-8	butyrylcholinesterase	Homo sapiens	133-137
32260512-7	2020	In most of the complexes, the orientation of the bases with respect to the ribose is in the high-syn region in the immediate vicinity of the barrier to syn   anti transitions.	Ribose	75-81	synemin	Homo sapiens	97-100
31928132-5	2020	Meanwhile, we found that SIRT6, an important upstream protein of PARP1, associated with PARP1, leading to the stimulation of polyADP-ribose polymerase activity.	Ribose	133-139	sirtuin 6	Homo sapiens	25-30
31928132-5	2020	Meanwhile, we found that SIRT6, an important upstream protein of PARP1, associated with PARP1, leading to the stimulation of polyADP-ribose polymerase activity.	Ribose	133-139	poly(ADP-ribose) polymerase 1	Homo sapiens	65-70
31928132-5	2020	Meanwhile, we found that SIRT6, an important upstream protein of PARP1, associated with PARP1, leading to the stimulation of polyADP-ribose polymerase activity.	Ribose	133-139	poly(ADP-ribose) polymerase 1	Homo sapiens	88-93
32260512-7	2020	In most of the complexes, the orientation of the bases with respect to the ribose is in the high-syn region in the immediate vicinity of the barrier to syn   anti transitions.	Ribose	75-81	synemin	Homo sapiens	152-155
31506465-4	2019	Ptch1+/-/ODCt/C57BL/6 mice show an altered metabolic landscape in the phenotypically normal skin, including restricted glucose availability, restricted ribose/deoxyribose flow and NADPH production, an accumulation of alpha-ketoglutarate, aconitate, and citrate that is associated with reversal of the tricarboxylic acid cycle, coupled with increased ketogenic/lipogenic activity via acetyl-CoA, 3-hydroybutyrate, and cholesterol metabolites.	Ribose	152-158	patched 1	Mus musculus	0-5
31958555-6	2020	LCP-1 had a molecular weight of 2.303 x 105 Da and 7.519 x 103 Da, and was composed of mannose (Man), ribose (Rib), rhamnose (Rha), glucuronic acid (GluA), galacturonic acid (GalA), glucose (Glu), galactose (Gal), xylose (Xyl), arabinose (Ara) and fucuronic (Fuc).	Ribose	102-108	lymphocyte cytosolic protein 1	Mus musculus	0-5
31958555-6	2020	LCP-1 had a molecular weight of 2.303 x 105 Da and 7.519 x 103 Da, and was composed of mannose (Man), ribose (Rib), rhamnose (Rha), glucuronic acid (GluA), galacturonic acid (GalA), glucose (Glu), galactose (Gal), xylose (Xyl), arabinose (Ara) and fucuronic (Fuc).	Ribose	110-113	lymphocyte cytosolic protein 1	Mus musculus	0-5
33062176-1	2020	A side-by-side pharmacological comparison of ribose and (N)-methanocarba (bicyclo[3.1.0]hexane) nucleosides as A3AR agonists indicated that the bicyclic pseudoribose ring constraint provided higher affinity/selectivity at human and mouse A3AR.	Ribose	45-51	adenosine A3 receptor	Homo sapiens	111-115
31610377-11	2019	We concluded that ribose-ring to chain transformation, as well as the type of the nucleobase, are parameters of minor significance to NPP1 inhibition, whereas the major parameter is Palpha-dithio-substitution.	Ribose	18-24	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	134-138
31375477-11	2019	Ribose offers a readily testable dietary therapy for CRPPA myopathy, with possible applicability for patients with FKRP and FKTN myopathy.	Ribose	0-6	fukutin related protein	Homo sapiens	115-119
31958555-7	2020	The molecular weight of LCP-2 was 2.655 x 105 Da, and its monosaccharide constituents were Man, Rib, Rha, GluA, Glu, Gal, Xyl, Ara and Fuc.	Ribose	96-99	lymphocyte cytosolic protein 2	Mus musculus	24-29
31084346-6	2020	Study found that when tRNAGln specific for GlnRS was docked into the active site of the TtGlnRS enzyme it interacts with 2" OH on the ribose acceptor end of the tRNA.	Ribose	134-140	glutamine--tRNA ligase/YqeY domain fusion protein	Thermus thermophilus HB8	43-48
32231086-8	2020	Using FurNAD-RNAs, we discovered that the eukaryotic glycohydrolase CD38 processes NAD-capped RNA in vitro into ADP-ribose-modified-RNA and nicotinamide and therefore might act as a decapping enzyme in vivo.	Ribose	116-122	CD38 molecule	Homo sapiens	68-72
32092898-2	2020	ADP-ribosylarginine hydrolase 1 (ARH1) catalyzes the cleavage of the ADP-ribose-arginine bond, regenerating (arginine)protein.	Ribose	73-79	ADP-ribosylarginine hydrolase	Homo sapiens	0-31
32092898-2	2020	ADP-ribosylarginine hydrolase 1 (ARH1) catalyzes the cleavage of the ADP-ribose-arginine bond, regenerating (arginine)protein.	Ribose	73-79	ADP-ribosylarginine hydrolase	Homo sapiens	33-37
31615893-4	2019	Previously, cAMP modifications at position N 6 of the adenine ring (PKA) and position 2"-OH of the ribose (Epac) have been used to produce target-selective compounds.	Ribose	99-105	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	107-111
31737627-0	2019	D-Ribose Induces Podocyte NLRP3 Inflammasome Activation and Glomerular Injury via AGEs/RAGE Pathway.	Ribose	0-8	NLR family, pyrin domain containing 3	Mus musculus	26-31
31737627-3	2019	Given that D-ribose was reported to induce advanced glycation end products (AGEs) formation, the present study tested whether D-ribose induces NLRP3 activation and associated glomerular injury via AGEs/receptor of AGEs (RAGE) signaling pathway.	Ribose	126-134	NLR family, pyrin domain containing 3	Mus musculus	143-148
31737627-5	2019	Administration of D-ribose daily for 30 days was found to induce NLRP3 inflammasome formation in glomerular podocyte, as shown by increased co-localization of NLRP3 with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) or caspase-1.	Ribose	18-26	NLR family, pyrin domain containing 3	Mus musculus	65-70
31737627-5	2019	Administration of D-ribose daily for 30 days was found to induce NLRP3 inflammasome formation in glomerular podocyte, as shown by increased co-localization of NLRP3 with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) or caspase-1.	Ribose	18-26	NLR family, pyrin domain containing 3	Mus musculus	159-164
31737627-5	2019	Administration of D-ribose daily for 30 days was found to induce NLRP3 inflammasome formation in glomerular podocyte, as shown by increased co-localization of NLRP3 with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) or caspase-1.	Ribose	18-26	caspase 1	Mus musculus	259-268
31737627-6	2019	This D-ribose-induced NLRP3 inflammasome formation was accompanied by its activation as evidenced by increased IL-1beta production, a major product of NLRP3 inflammasome.	Ribose	5-13	NLR family, pyrin domain containing 3	Mus musculus	22-27
31737627-6	2019	This D-ribose-induced NLRP3 inflammasome formation was accompanied by its activation as evidenced by increased IL-1beta production, a major product of NLRP3 inflammasome.	Ribose	5-13	interleukin 1 beta	Mus musculus	111-119
31737627-6	2019	This D-ribose-induced NLRP3 inflammasome formation was accompanied by its activation as evidenced by increased IL-1beta production, a major product of NLRP3 inflammasome.	Ribose	5-13	NLR family, pyrin domain containing 3	Mus musculus	151-156
31737627-10	2019	In cell studies, we also confirmed that D-ribose induced NLRP3 inflammasome formation and activation in podocytes, which was significantly blocked by caspase-1 inhibitor, YvAD.	Ribose	40-48	NLR family, pyrin domain containing 3	Mus musculus	57-62
31737627-10	2019	In cell studies, we also confirmed that D-ribose induced NLRP3 inflammasome formation and activation in podocytes, which was significantly blocked by caspase-1 inhibitor, YvAD.	Ribose	40-48	caspase 1	Mus musculus	150-159
31737627-11	2019	Mechanically, AGEs formation inhibition and cleavage or silencing of RAGE gene were shown to suppress D-ribose-induced NLRP3 inflammasome formation and activation, as shown by significant reduction of NLRP3 inflammasome molecular aggregation, caspase-1 activity and IL-1beta production.	Ribose	102-110	NLR family, pyrin domain containing 3	Mus musculus	119-124
31737627-11	2019	Mechanically, AGEs formation inhibition and cleavage or silencing of RAGE gene were shown to suppress D-ribose-induced NLRP3 inflammasome formation and activation, as shown by significant reduction of NLRP3 inflammasome molecular aggregation, caspase-1 activity and IL-1beta production.	Ribose	102-110	caspase 1	Mus musculus	243-252
31737627-11	2019	Mechanically, AGEs formation inhibition and cleavage or silencing of RAGE gene were shown to suppress D-ribose-induced NLRP3 inflammasome formation and activation, as shown by significant reduction of NLRP3 inflammasome molecular aggregation, caspase-1 activity and IL-1beta production.	Ribose	102-110	interleukin 1 beta	Mus musculus	266-274
31737627-12	2019	These results strongly suggest that relatively long term administration of D-ribose induces NLRP3 inflammasome formation and activation in podocytes via AGEs/RAGE signaling pathway, which may be one of important triggering mechanisms leading to diabetic nephropathy.	Ribose	75-83	NLR family, pyrin domain containing 3	Mus musculus	92-97
31492921-5	2019	In vitro, exposure of MIN6 cells or islets to cytokines, palmitate, thapsigargin or ribose upregulated Phlda3 mRNA and protein levels, concurrent with the induction of ER stress (Ddit3 and Trb3) and antioxidant (Hmox1) genes.	Ribose	84-90	pleckstrin homology like domain, family A, member 3	Mus musculus	103-109
31278906-2	2019	SARM1 activity depends on the integrity of the protein"s SAM domains, as well as on the enzymatic conversion of NAD+ to ADPR (ADP Ribose) products by the SARM1"s TIR domain.	Ribose	130-136	sterile alpha and TIR motif containing 1	Homo sapiens	0-5
31278906-2	2019	SARM1 activity depends on the integrity of the protein"s SAM domains, as well as on the enzymatic conversion of NAD+ to ADPR (ADP Ribose) products by the SARM1"s TIR domain.	Ribose	130-136	sterile alpha and TIR motif containing 1	Homo sapiens	154-159
31492921-5	2019	In vitro, exposure of MIN6 cells or islets to cytokines, palmitate, thapsigargin or ribose upregulated Phlda3 mRNA and protein levels, concurrent with the induction of ER stress (Ddit3 and Trb3) and antioxidant (Hmox1) genes.	Ribose	84-90	DNA-damage inducible transcript 3	Mus musculus	179-184
31492921-5	2019	In vitro, exposure of MIN6 cells or islets to cytokines, palmitate, thapsigargin or ribose upregulated Phlda3 mRNA and protein levels, concurrent with the induction of ER stress (Ddit3 and Trb3) and antioxidant (Hmox1) genes.	Ribose	84-90	tribbles pseudokinase 3	Mus musculus	189-193
31492921-5	2019	In vitro, exposure of MIN6 cells or islets to cytokines, palmitate, thapsigargin or ribose upregulated Phlda3 mRNA and protein levels, concurrent with the induction of ER stress (Ddit3 and Trb3) and antioxidant (Hmox1) genes.	Ribose	84-90	heme oxygenase 1	Mus musculus	212-217
31492921-10	2019	Knockdown of Phlda3 also potentiated apoptosis under oxidative stress conditions induced by ribose treatment.	Ribose	92-98	pleckstrin homology like domain family A member 3	Homo sapiens	13-19
31085227-5	2019	Here, we showed that the yield of glycated human serum albumin with d-ribose was at least two-fold higher than that with d-glucose in a 2-week incubation.	Ribose	68-76	albumin	Rattus norvegicus	49-62
31085227-6	2019	The glycation of human serum albumin (HSA) with d-ribose was much faster than that with d-glucose, as determined by monitoring changes in the fluorescent intensity of glycation products with time.	Ribose	48-56	albumin	Rattus norvegicus	23-36
31439792-5	2019	The crystal structures of ribose and NADP+ (the oxidized form of nicotinamide adenine dinucleotide phosphate) complexes of SARM1 and plant NLR RUN1 TIR domains, respectively, reveal a conserved substrate binding site.	Ribose	26-32	sterile alpha and TIR motif containing 1	Homo sapiens	123-128
31049804-0	2019	D-ribose increases triglyceride via upregulation of DGAT in the liver.	Ribose	0-8	diacylglycerol O-acyltransferase 1	Homo sapiens	52-56
31307014-4	2019	The expression and activity of transketolase (TKT), an important enzyme in the pentose shunt, were decreased in the brain, indicating that TKT may be involved in D-ribose metabolism in T1DM.	Ribose	162-170	transketolase	Homo sapiens	31-44
31307014-4	2019	The expression and activity of transketolase (TKT), an important enzyme in the pentose shunt, were decreased in the brain, indicating that TKT may be involved in D-ribose metabolism in T1DM.	Ribose	162-170	transketolase	Homo sapiens	46-49
31307014-4	2019	The expression and activity of transketolase (TKT), an important enzyme in the pentose shunt, were decreased in the brain, indicating that TKT may be involved in D-ribose metabolism in T1DM.	Ribose	162-170	transketolase	Homo sapiens	139-142
31190358-4	2019	The thermodynamic differences appear to be exploited by secondary structural differences between models for the ancestral aaRS called synthetase Urzymes and reinforced by packing of aromatic amino acid side chains against the nonpolar face of the ribose of A76 if and only if the tRNA CCA sequence forms a hairpin.	Ribose	247-253	alanyl-tRNA synthetase 1	Homo sapiens	122-126
30936012-5	2019	SP1-1 (4.56 x 105 Da) was mainly composed of mannose, ribose, glucuronic acid, glucose, xylose and arabinose with molar ratios of 2.14:3.61:1:2.86:5.98:36.39.	Ribose	54-60	trans-acting transcription factor 1	Mus musculus	0-5
31147539-6	2019	We obtained the 2.7 A crystal structure of the human NOCT NADPH complex, which revealed that NOCT recognizes the chemically unique ribose-phosphate backbone of the metabolite, placing the 2"-terminal phosphate productively for removal.	Ribose	131-137	nocturnin	Homo sapiens	53-57
31147539-6	2019	We obtained the 2.7 A crystal structure of the human NOCT NADPH complex, which revealed that NOCT recognizes the chemically unique ribose-phosphate backbone of the metabolite, placing the 2"-terminal phosphate productively for removal.	Ribose	131-137	nocturnin	Homo sapiens	93-97
30978018-0	2019	Synthesis of Terminal Ribose Analogues of Adenosine 5"-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2.	Ribose	22-28	transient receptor potential cation channel subfamily M member 2	Homo sapiens	136-141
30978018-4	2019	A detailed understanding of how ADPR interacts with the TRPM2 ligand binding domain is lacking, hampering the rational design of modulators, but the terminal ribose of ADPR is known to be essential for activation.	Ribose	158-164	transient receptor potential cation channel subfamily M member 2	Homo sapiens	56-61
30771382-0	2019	Lysosomal regulation of extracellular vesicle excretion during d-ribose-induced NLRP3 inflammasome activation in podocytes.	Ribose	63-71	NLR family pyrin domain containing 3	Homo sapiens	80-85
30771382-3	2019	In this study, we hypothesized that the NLRP3 inflammasome product, IL-1beta in response to exogenously administrated and endogenously produced d-ribose stimulation is released via extracellular vesicles including EVs via a sphingolipid-mediated molecular mechanisms controlling lysosome and multivesicular body (MVB) interaction.	Ribose	144-152	NLR family pyrin domain containing 3	Homo sapiens	40-45
30771382-3	2019	In this study, we hypothesized that the NLRP3 inflammasome product, IL-1beta in response to exogenously administrated and endogenously produced d-ribose stimulation is released via extracellular vesicles including EVs via a sphingolipid-mediated molecular mechanisms controlling lysosome and multivesicular body (MVB) interaction.	Ribose	144-152	interleukin 1 beta	Homo sapiens	68-76
30771382-4	2019	First, we demonstrated that both endogenous and exogenous d-ribose induced NLRP3 inflammasome activation to produce IL-1beta, which was released via EVs in podocytes.	Ribose	58-66	NLR family pyrin domain containing 3	Homo sapiens	75-80
30771382-4	2019	First, we demonstrated that both endogenous and exogenous d-ribose induced NLRP3 inflammasome activation to produce IL-1beta, which was released via EVs in podocytes.	Ribose	58-66	interleukin 1 beta	Homo sapiens	116-124
30771382-5	2019	Then, we found that colocalization of marker MVB marker VPS16 with IL-1beta within podocytes increased upon d-ribose stimulation, which was accompanied by decreased colocalization of lysosome marker Lamp-1 and VPS16, suggesting decrease in MVB inclusion of IL-1beta due to reduced lysosome and MVB interaction.	Ribose	108-116	VPS16 core subunit of CORVET and HOPS complexes	Homo sapiens	56-61
30771382-5	2019	Then, we found that colocalization of marker MVB marker VPS16 with IL-1beta within podocytes increased upon d-ribose stimulation, which was accompanied by decreased colocalization of lysosome marker Lamp-1 and VPS16, suggesting decrease in MVB inclusion of IL-1beta due to reduced lysosome and MVB interaction.	Ribose	108-116	interleukin 1 beta	Homo sapiens	67-75
30771382-5	2019	Then, we found that colocalization of marker MVB marker VPS16 with IL-1beta within podocytes increased upon d-ribose stimulation, which was accompanied by decreased colocalization of lysosome marker Lamp-1 and VPS16, suggesting decrease in MVB inclusion of IL-1beta due to reduced lysosome and MVB interaction.	Ribose	108-116	lysosomal associated membrane protein 1	Homo sapiens	199-205
30771382-5	2019	Then, we found that colocalization of marker MVB marker VPS16 with IL-1beta within podocytes increased upon d-ribose stimulation, which was accompanied by decreased colocalization of lysosome marker Lamp-1 and VPS16, suggesting decrease in MVB inclusion of IL-1beta due to reduced lysosome and MVB interaction.	Ribose	108-116	VPS16 core subunit of CORVET and HOPS complexes	Homo sapiens	210-215
30771382-5	2019	Then, we found that colocalization of marker MVB marker VPS16 with IL-1beta within podocytes increased upon d-ribose stimulation, which was accompanied by decreased colocalization of lysosome marker Lamp-1 and VPS16, suggesting decrease in MVB inclusion of IL-1beta due to reduced lysosome and MVB interaction.	Ribose	108-116	interleukin 1 beta	Homo sapiens	257-265
30771382-8	2019	These results suggest that inflammasome-derived products such as IL-1beta during d-ribose stimulation are released via EVs, in which lysosomal sphingolipid-mediated regulation of lysosome function plays an important role.	Ribose	81-89	interleukin 1 beta	Homo sapiens	65-73
31273204-2	2019	Upon activation, PARP-1 synthesizes a structurally complex polymer composed of ADP-ribose units that facilitates local chromatin relaxation and the recruitment of DNA repair factors.	Ribose	83-89	poly(ADP-ribose) polymerase 1	Homo sapiens	17-23
30715843-6	2019	In this study, four physiologically relevant monosaccharides, methylglyoxal, glucose, fructose, and ribose were used to glycate human insulin and two C-terminus truncated insulin analogues.	Ribose	100-106	insulin	Homo sapiens	134-141
30715843-6	2019	In this study, four physiologically relevant monosaccharides, methylglyoxal, glucose, fructose, and ribose were used to glycate human insulin and two C-terminus truncated insulin analogues.	Ribose	100-106	insulin	Homo sapiens	171-178
30572123-3	2019	Ribose methylation is formed in RNA by two alternative enzymatic mechanisms: either by stand-alone protein enzymes or by complex assembly of proteins associated with snoRNA guides (sno(s)RNPs).	Ribose	0-6	small nucleolar RNA, C/D box 14E	Homo sapiens	166-172
30949549-0	2019	The Role of Poly(ADP-ribose) in alpha-Synuclein Neurodegeneration: Another Piece of the Puzzle for alpha-Synucleinopathies.	Ribose	20-28	synuclein alpha	Homo sapiens	32-47
30673214-3	2019	Herein it is demonstrated that AbmH is a pyridoxal 5"-phosphate (PLP)-dependent transaldolase that catalyzes a threo-selective aldol-type reaction to generate the thioheptose core with a d-ribofuranose ring and an l-amino acid moiety.	Ribose	187-201	pyridoxal phosphatase	Homo sapiens	65-68
30312697-5	2019	The point of this examination was to look at the connection between d-ribose glycated ApoB100 (ApoB100-AGE) with obesity and rheumatoid arthritis.	Ribose	68-76	apolipoprotein B	Homo sapiens	86-93
30312697-5	2019	The point of this examination was to look at the connection between d-ribose glycated ApoB100 (ApoB100-AGE) with obesity and rheumatoid arthritis.	Ribose	68-76	apolipoprotein B	Homo sapiens	95-106
30718435-4	2019	We discovered that (i) N 6-methyladenine is the most favorable nucleobase substrate of FTO, (ii) FTO displays the same demethylation activity toward internal m6A and m6Am in the same RNA sequence, suggesting that the substrate specificity of FTO primarily results from the interaction of residues in the catalytic pocket with the nucleobase (rather than the ribose ring), and (iii) the sequence and the tertiary structure of RNA can affect the catalytic activity of FTO.	Ribose	358-364	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	97-100
30718435-4	2019	We discovered that (i) N 6-methyladenine is the most favorable nucleobase substrate of FTO, (ii) FTO displays the same demethylation activity toward internal m6A and m6Am in the same RNA sequence, suggesting that the substrate specificity of FTO primarily results from the interaction of residues in the catalytic pocket with the nucleobase (rather than the ribose ring), and (iii) the sequence and the tertiary structure of RNA can affect the catalytic activity of FTO.	Ribose	358-364	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	97-100
30718435-4	2019	We discovered that (i) N 6-methyladenine is the most favorable nucleobase substrate of FTO, (ii) FTO displays the same demethylation activity toward internal m6A and m6Am in the same RNA sequence, suggesting that the substrate specificity of FTO primarily results from the interaction of residues in the catalytic pocket with the nucleobase (rather than the ribose ring), and (iii) the sequence and the tertiary structure of RNA can affect the catalytic activity of FTO.	Ribose	358-364	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	97-100
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	Ribose	33-40	poly (ADP-ribose) polymerase family, member 1	Mus musculus	147-152
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	Ribose	33-40	poly (ADP-ribose) polymerase family, member 1	Mus musculus	162-168
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	Ribose	33-40	poly (ADP-ribose) polymerase family, member 2	Mus musculus	170-176
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	Ribose	33-40	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	Mus musculus	178-189
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	Ribose	33-40	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	Mus musculus	195-206
30691122-1	2019	Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2).	Ribose	33-40	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	Mus musculus	208-216
30740729-5	2019	PNP catalyzes the cleavage of purine ribo- and d-ribo-nucleosides into ribose/deoxyribose phosphate and free bases, starting catabolism to uric acid.	Ribose	71-77	purine nucleoside phosphorylase	Homo sapiens	0-3
31602603-5	2019	Ribose-seq utilizes Arabidopsis thaliana tRNA ligase (AtRNL), which enables ligation of 2"-phosphate termini of DNA molecules terminating with an rNMP to the 5"-phosphate end of the same DNA molecules.	Ribose	0-6	RNAligase	Arabidopsis thaliana	54-59
29923087-6	2019	Whole exome sequencing revealed compound heterozygous variants c.512_514delCCT (p.Ser171del) and c.931G &gt; T (p.Gly311Trp) in TALDO1 (HGNC:11559), which encodes transaldolase (EC 2.2.1.2), a key enzyme in ribose metabolism.	Ribose	207-213	transaldolase 1	Homo sapiens	128-134
30455710-1	2018	Proteins of the Poly(ADP-Ribose) Polymerase (PARP) family modify target proteins by covalent attachment of ADP-ribose moieties onto amino acid side chains.	Ribose	111-117	poly(ADP-ribose) polymerase	Arabidopsis thaliana	16-43
30539457-5	2019	Their ribose backbone renders them sensitive to simple degradation over time and they are the target molecule for numerous and abundant ribonucleases which have evolved to chop them to pieces with extreme efficiency.	Ribose	6-12	DNA damage inducible transcript 3	Homo sapiens	172-176
30467180-2	2018	It has a C-terminal NUDT9 homology (NUDT9H) domain responsible for binding adenosine diphosphate (ADP)-ribose (ADPR), and both ADPR and calcium (Ca2+) are required for TRPM2 activation.	Ribose	103-109	nudix hydrolase 9	Homo sapiens	20-25
30467180-2	2018	It has a C-terminal NUDT9 homology (NUDT9H) domain responsible for binding adenosine diphosphate (ADP)-ribose (ADPR), and both ADPR and calcium (Ca2+) are required for TRPM2 activation.	Ribose	103-109	transient receptor potential cation channel subfamily M member 2	Homo sapiens	36-42
30467180-2	2018	It has a C-terminal NUDT9 homology (NUDT9H) domain responsible for binding adenosine diphosphate (ADP)-ribose (ADPR), and both ADPR and calcium (Ca2+) are required for TRPM2 activation.	Ribose	103-109	transient receptor potential cation channel subfamily M member 2	Homo sapiens	168-173
30472116-7	2018	Despite this apparent similarity, we elucidate the structural basis for the selective inhibition of ARH3 by the ADP-ribose analogues ADP-HPD and arginine-ADP-ribose.	Ribose	116-122	ADP-ribosylserine hydrolase	Homo sapiens	100-104
30605331-0	2019	Design and in Vivo Characterization of A1 Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series.	Ribose	84-90	adenosine A1 receptor	Mus musculus	39-60
30605331-8	2019	Thus, we identified, and characterized in vivo, ribose and methanocarba nucleosides, including with A1AR-enhancing N6-dicyclobutylmethyl-adenine and 1,2,4-triazole-3-carboxamide (40, MRS7451) nucleobases.	Ribose	48-54	adenosine A1 receptor	Mus musculus	100-104
29968072-2	2018	Upon detection of a DNA strand break, PARP1 binds to the DNA, cleaves nicotinamide adenine dinucleotide between nicotinamide and ribose and then modifies the DNA nuclear acceptor proteins by formation of a bond between the protein and the ADP-ribose residue.	Ribose	129-135	poly(ADP-ribose) polymerase 1	Homo sapiens	38-43
29968072-2	2018	Upon detection of a DNA strand break, PARP1 binds to the DNA, cleaves nicotinamide adenine dinucleotide between nicotinamide and ribose and then modifies the DNA nuclear acceptor proteins by formation of a bond between the protein and the ADP-ribose residue.	Ribose	243-249	poly(ADP-ribose) polymerase 1	Homo sapiens	38-43
30500844-5	2018	ARH1 specifically cleaves the ADP-ribose-arginine bond.	Ribose	34-40	ADP-ribosylarginine hydrolase	Mus musculus	0-4
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Ribose	116-122	ADP-ribosyltransferase 1	Mus musculus	60-84
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Ribose	116-122	ADP-ribosyltransferase 1	Mus musculus	86-90
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Ribose	116-122	ADP-ribosylarginine hydrolase	Mus musculus	161-192
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Ribose	116-122	ADP-ribosylarginine hydrolase	Mus musculus	194-198
30633249-3	2018	Both APE1 and TDP1 are more efficient in removing ribose-modified dNMP residues from mismatched pairs rather than canonical pairs.	Ribose	50-56	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	5-9
30340901-5	2018	Only two compounds showed a preference for BuChE, namely 7a (d-ribose derivative) and 6b (d-xylose derivative).	Ribose	61-69	butyrylcholinesterase	Homo sapiens	43-48
30102387-9	2018	Testing permutations of the nucleobase at ribose-methylated position 54 suggested that the extent of silencing and antagonism of the TLR7 response was governed by hydrogen patterns and lipophilic interactions of the nucleobase.	Ribose	42-48	toll like receptor 7	Homo sapiens	133-137
30633249-3	2018	Both APE1 and TDP1 are more efficient in removing ribose-modified dNMP residues from mismatched pairs rather than canonical pairs.	Ribose	50-56	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	14-18
29685656-5	2018	The protein X-ray crystal structures of 1 and 2 in complex with CA II show that it is not the halogen-hydrophobic interactions that give compound 2 a greater binding energy but a slight movement in orientation of the ribose ring that allows better hydrogen bonds to CA residues.	Ribose	217-223	carbonic anhydrase 2	Homo sapiens	64-69
29907568-2	2018	ARH3 degrades poly(ADP-ribose) to protect cells from poly(ADP-ribose)-dependent cell death, reverses serine mono(ADP-ribosyl)ation, and hydrolyzes O-acetyl-ADP-ribose, a product of Sirtuin-catalyzed histone deacetylation.	Ribose	23-29	ADP-ribosylserine hydrolase	Homo sapiens	0-4
30086130-6	2018	Moreover, Ca2+ imaging experiments reveal that Gr28a-expressing taste neurons are activated by ribose, RNA and some ribonucleosides and that these responses can be conveyed to Gr43aGAL4 fructose-sensing neurons by expressing single members of the Gr28 gene family.	Ribose	95-101	Gustatory receptor 28a	Drosophila melanogaster	47-52
30101366-0	2018	D-ribose induces nephropathy through RAGE-dependent NF-kappaB inflammation.	Ribose	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-61
30101366-4	2018	The present study tested whether D-ribose induces renal dysfunction via the RAGE-dependent NF-kappaB signaling pathway.	Ribose	33-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	91-100
30101366-7	2018	Furthermore, immunohistochemistry showed that NF-kappaB, AGEs, and receptor of AGEs (RAGE) increased in the kidneys of the mice with D-ribose treatment.	Ribose	133-141	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	46-55
30101366-8	2018	In vitro, by western blot and immunofluorescent staining, we confirmed that D-ribose induced NF-kappaB activation and accumulation of AGEs and RAGE in mesangial cells.	Ribose	76-84	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-102
30101366-10	2018	Silencing the RAGE gene blocked the phosphorylation of NF-kappaB induced by D-ribose.	Ribose	76-84	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	55-64
30101366-11	2018	These results strongly suggest that D-ribose induced NF-kappaB inflammation in a RAGE-dependent manner, which may be a triggering mechanism leading to nephropathy.	Ribose	36-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	53-62
29779627-8	2018	The MMP-2 and cathepsin K activities in ribose-treated dentine powder were also quantified using ELISA.	Ribose	40-46	matrix metallopeptidase 2	Homo sapiens	4-9
29779627-8	2018	The MMP-2 and cathepsin K activities in ribose-treated dentine powder were also quantified using ELISA.	Ribose	40-46	cathepsin K	Homo sapiens	14-25
29844165-4	2018	Serine and ribose synthesis have been identified as downstream pathways fed by PEPCK in cancer cells.	Ribose	11-17	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	79-84
29431122-1	2018	OBJECTIVES: The enzyme poly(ADP-ribose) polymerase-1 (PARP-1) transfers negatively charged ADP-ribose units to target proteins.	Ribose	32-38	poly (ADP-ribose) polymerase family, member 1	Mus musculus	54-60
29779382-3	2018	We show that potency is manifest via tetrahyropyran ring conformations that are housed in the ribose binding pocket of parasite lysyl tRNA synthetase (KRS).	Ribose	94-100	lysyl-tRNA synthetase 1	Homo sapiens	128-149
29779382-3	2018	We show that potency is manifest via tetrahyropyran ring conformations that are housed in the ribose binding pocket of parasite lysyl tRNA synthetase (KRS).	Ribose	94-100	lysyl-tRNA synthetase 1	Homo sapiens	151-154
29488986-4	2018	Combining this structural sampling with NOE fitting, we demonstrate, for S-adenosylmethionine (aqueous solution at pH 7.0), significant improvements are made to the fit of populations to the experimental data, revealing a strong overall preference for the syn conformation of the adenosyl group relative to the ribose ring, but with less discrimination for the conformation of the ribose ring itself.	Ribose	311-317	synemin	Homo sapiens	256-259
29513344-0	2018	Antioxidant activity and inhibitory effects of 2-hydroxy-3-methylcyclopent-2-enone isolated from ribose-histidine Maillard reaction products on aldose reductase and tyrosinase.	Ribose	97-103	aldo-keto reductase family 1 member B	Homo sapiens	144-160
29513344-0	2018	Antioxidant activity and inhibitory effects of 2-hydroxy-3-methylcyclopent-2-enone isolated from ribose-histidine Maillard reaction products on aldose reductase and tyrosinase.	Ribose	97-103	tyrosinase	Homo sapiens	165-175
28862361-11	2018	Type-I (COL1A1) and type-III (COL3A1) collagen gene expression increased significantly in immobilized joints relative to nonimmobilized joints in the ribose group, but was not affected in the saline group.	Ribose	150-156	collagen type I alpha 1 chain	Rattus norvegicus	8-14
28862361-11	2018	Type-I (COL1A1) and type-III (COL3A1) collagen gene expression increased significantly in immobilized joints relative to nonimmobilized joints in the ribose group, but was not affected in the saline group.	Ribose	150-156	collagen type III alpha 1 chain	Rattus norvegicus	30-36
28862361-12	2018	Ribose injection increased COL1A1 expression slightly and COL3A1 expression significantly in immobilized joints.	Ribose	0-6	collagen type I alpha 1 chain	Rattus norvegicus	27-33
28862361-12	2018	Ribose injection increased COL1A1 expression slightly and COL3A1 expression significantly in immobilized joints.	Ribose	0-6	collagen type III alpha 1 chain	Rattus norvegicus	58-64
29488986-4	2018	Combining this structural sampling with NOE fitting, we demonstrate, for S-adenosylmethionine (aqueous solution at pH 7.0), significant improvements are made to the fit of populations to the experimental data, revealing a strong overall preference for the syn conformation of the adenosyl group relative to the ribose ring, but with less discrimination for the conformation of the ribose ring itself.	Ribose	381-387	synemin	Homo sapiens	256-259
29487285-1	2018	PARP-1 cleaves NAD+ and transfers the resulting ADP-ribose moiety onto target proteins and onto subsequent polymers of ADP-ribose.	Ribose	52-58	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
29280631-0	2018	Liquid Chromatography High-Resolution Mass Spectrometry Identifies the Glycation Sites of Bovine Serum Albumin Induced by d-Ribose with Ultrasonic Treatment.	Ribose	122-130	albumin	Homo sapiens	97-110
29576747-6	2018	This review is focused on investigations on the role of CD38-cyclic ADP-ribose signaling in airway smooth muscle in the context of transcriptional and posttranscriptional regulation of CD38 expression.	Ribose	72-78	CD38 molecule	Homo sapiens	56-60
29343827-4	2018	We confirm the involvement of NUDT5 in ADP-ribose metabolism and dissociate a relationship to oxidized nucleotide sanitation.	Ribose	43-49	nudix hydrolase 5	Homo sapiens	30-35
29416880-2	2018	All three ribose O atoms are involved in hydrogen bonding and the crystal packing is largely determined by hydrogen-bonding or hydrogen-heteroatom inter-actions (O-H O, O-H N, N-H O, C-H O and C-H N) with one independent mol-ecule directly linked to four neighbouring mol-ecules and the other mol-ecule directly linked to six neighbouring mol-ecules.	Ribose	10-16	chimerin 1	Homo sapiens	162-198
29712969-8	2018	In response to DNA damage, which activates ARTD1/2 (PARP1/2) and promotes synthesis of poly-ADP-ribose chains, TARG1 re-localized to the nucleoplasm.	Ribose	96-102	poly(ADP-ribose) polymerase family member 12	Homo sapiens	43-50
29712969-8	2018	In response to DNA damage, which activates ARTD1/2 (PARP1/2) and promotes synthesis of poly-ADP-ribose chains, TARG1 re-localized to the nucleoplasm.	Ribose	96-102	poly(ADP-ribose) polymerase family member 12	Homo sapiens	52-59
29712969-8	2018	In response to DNA damage, which activates ARTD1/2 (PARP1/2) and promotes synthesis of poly-ADP-ribose chains, TARG1 re-localized to the nucleoplasm.	Ribose	96-102	O-acyl-ADP-ribose deacylase 1	Homo sapiens	111-116
29179156-1	2018	Upon DNA binding the poly(ADP-ribose) polymerase family of enzymes (PARPs) add multiple ADP-ribose subunits to themselves and other acceptor proteins.	Ribose	30-36	poly(ADP-ribose) polymerase 1	Homo sapiens	68-73
29070863-0	2017	PARP1-produced poly-ADP-ribose causes the PARP12 translocation to stress granules and impairment of Golgi complex functions.	Ribose	24-30	poly(ADP-ribose) polymerase 1	Homo sapiens	0-5
28886871-6	2018	Functional analyses of glucose or ribose treated DAF protein showed profound loss of its regulatory activity.	Ribose	34-40	CD55 molecule (Cromer blood group)	Homo sapiens	49-52
30112992-2	2018	PARP14 transfers a negatively charged ADP-ribose unit from a donor NAD+ molecule onto a target protein, post-translationally.	Ribose	42-48	poly(ADP-ribose) polymerase family member 14	Homo sapiens	0-6
29170518-7	2017	Molecular modelling was used to explore the interaction of the CD38 catalytic residue Glu-226 with the "northern" ribose.	Ribose	114-120	CD38 molecule	Homo sapiens	63-67
29170518-10	2017	Results highlight the key role of the "northern" ribose in the interaction of cADPR with CD38.	Ribose	49-55	CD38 molecule	Homo sapiens	89-93
29250520-0	2017	Design, Synthesis, and Evaluation of Ribose-Modified Anilinopyrimidine Derivatives as EGFR Tyrosine Kinase Inhibitors.	Ribose	37-43	epidermal growth factor receptor	Homo sapiens	86-90
28952648-3	2017	Hydroxyapatite (HAp), which consists of phosphate and calcium ions, worked continuously for cross-aldol reactions and Lobry de Bruyn-van Ekenstein transformations to yield ribose from formaldehyde and glycolaldehyde.	Ribose	172-178	BAG cochaperone 1	Homo sapiens	16-19
28952648-5	2017	Ribose production by HAp may be a reason why a pentose backbone was incorporated into nucleic acids in the prebiotic world.	Ribose	0-6	BAG cochaperone 1	Homo sapiens	21-24
30097872-1	2018	Mono-ADP-ribosyltransferases of the PARP/ARTD enzyme family are enzymes catalyzing the transfer of a single ADP-ribose unit to target proteins.	Ribose	112-118	poly(ADP-ribose) polymerase 1	Homo sapiens	36-40
30097878-1	2018	Mouse T cells express the toxin-related ecto-ADP-ribosyltransferase ARTC2 that catalyzes the posttranslational ADP-ribosylation of cell surface proteins by transferring the ADP-ribose group of its substrate nicotinamide adenine dinucleotide (NAD+) to arginine residues of its target proteins.	Ribose	177-183	ADP-ribosyltransferase 2a	Mus musculus	68-73
30097881-10	2018	Finally, the enriched DNA is analyzed by qPCR or deep-sequencing experiments to determine which genomic loci contain ADP-ribose modifications mediated by the specific PARP protein of interest.	Ribose	121-127	poly(ADP-ribose) polymerase 1	Homo sapiens	167-171
29054115-5	2017	ADP-ribosylation of DNA mediated by PARP3 attaches a single mono-ADP-ribose moiety to the phosphate group at the terminal ends of DNA.	Ribose	69-75	poly(ADP-ribose) polymerase family member 3	Homo sapiens	36-41
29070863-0	2017	PARP1-produced poly-ADP-ribose causes the PARP12 translocation to stress granules and impairment of Golgi complex functions.	Ribose	24-30	poly(ADP-ribose) polymerase family member 12	Homo sapiens	42-48
28736243-5	2017	The islet-type ryanodine receptor caused a greater increase in the Ca2+ release by caffeine when expressed in HEK293 cells pre-treated with cyclic ADP-ribose, suggesting that the novel ryanodine receptor is an intracellular target for the CD38-cyclic ADP-ribose signal system in mammalian cells and that the tissue-specific alternative splicing of type 2 ryanodine receptor mRNA plays an important role in the functioning of the cyclic ADP-ribose-sensitive Ca2+ release.	Ribose	151-157	ryanodine receptor 2	Homo sapiens	4-33
28736243-5	2017	The islet-type ryanodine receptor caused a greater increase in the Ca2+ release by caffeine when expressed in HEK293 cells pre-treated with cyclic ADP-ribose, suggesting that the novel ryanodine receptor is an intracellular target for the CD38-cyclic ADP-ribose signal system in mammalian cells and that the tissue-specific alternative splicing of type 2 ryanodine receptor mRNA plays an important role in the functioning of the cyclic ADP-ribose-sensitive Ca2+ release.	Ribose	151-157	CD38 molecule	Homo sapiens	239-243
28736243-5	2017	The islet-type ryanodine receptor caused a greater increase in the Ca2+ release by caffeine when expressed in HEK293 cells pre-treated with cyclic ADP-ribose, suggesting that the novel ryanodine receptor is an intracellular target for the CD38-cyclic ADP-ribose signal system in mammalian cells and that the tissue-specific alternative splicing of type 2 ryanodine receptor mRNA plays an important role in the functioning of the cyclic ADP-ribose-sensitive Ca2+ release.	Ribose	151-157	ryanodine receptor 2	Homo sapiens	348-373
29423136-5	2017	This suggests that the distal dinucleotide P2Y6R binding site prefers a ribose-like group that can attain a (N) conformation, rather than (S).	Ribose	72-78	pyrimidinergic receptor P2Y6	Homo sapiens	43-48
28687616-4	2017	HuR-dependent upregulation of PARG expression facilitated DNA repair via hydrolysis of polyADP-ribose on related repair proteins.	Ribose	95-101	ELAV like RNA binding protein 1	Homo sapiens	0-3
28687616-4	2017	HuR-dependent upregulation of PARG expression facilitated DNA repair via hydrolysis of polyADP-ribose on related repair proteins.	Ribose	95-101	poly(ADP-ribose) glycohydrolase	Homo sapiens	30-34
28576825-4	2017	Ribose 2"-O-methylation is of particular importance and has been reported to antagonize TLR7/8 activation.	Ribose	0-6	toll like receptor 7	Homo sapiens	88-92
28824383-1	2017	Poly (ADP-ribose) polymerases (PARPs) are enzymes that catalyze ADP-ribose units transfer from NAD to their substrate proteins.	Ribose	10-16	poly (ADP-ribose) polymerase family, member 1	Mus musculus	31-36
28544567-4	2017	We designed hybrid structures of dasatinib and the previously known EPHA2 binders CHEMBL249097, PD-173955, and a known EPHB4 inhibitor in order to exploit both the ATP pocket entrance as well as the ribose pocket as binding epitopes in the kinase EPHA2.	Ribose	199-205	EPH receptor A2	Homo sapiens	68-73
28288146-6	2017	We show that increasing IEC poly-ADP-ribose chains can be measured over the first 3 weeks of life, indicating an increase in IEC PARP activity.	Ribose	37-43	poly (ADP-ribose) polymerase family, member 1	Mus musculus	129-133
28720704-0	2017	Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels.	Ribose	85-91	CD38 molecule	Homo sapiens	40-44
28720704-0	2017	Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels.	Ribose	85-91	calcium and integrin binding 1	Homo sapiens	50-54
28740101-5	2017	Inhibition of p38 also increased the immediate accumulation of XRCC1 at site of DNA damage in a poly(ADP)-ribose (PAR) dependent manner.	Ribose	106-112	mitogen-activated protein kinase 14	Homo sapiens	14-17
28740101-5	2017	Inhibition of p38 also increased the immediate accumulation of XRCC1 at site of DNA damage in a poly(ADP)-ribose (PAR) dependent manner.	Ribose	106-112	X-ray repair cross complementing 1	Homo sapiens	63-68
28697341-1	2017	In this issue of Cancer Cell, Singh and colleagues report a role for MUC1-induced HIF expression in rewiring ribose synthesis, which drives pyridimine production as a possible resistance mechanism to gemcitabine, adding to complexity and multiple paths to resistance.	Ribose	109-115	mucin 1, cell surface associated	Homo sapiens	69-73
28263025-4	2017	PARP catalyzes poly(ADP-ribosyl)ation of proteins by repeatedly adding ADP-ribose units onto proteins using nicotinamide adenine dinucleotide (NAD+ ) as the donor.	Ribose	75-81	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
28515263-0	2017	Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.	Ribose	63-69	transient receptor potential cation channel subfamily M member 2	Homo sapiens	35-40
28515263-5	2017	All novel ADPR derivatives modified in the terminal ribose, including that with the seemingly minor change of methylating the anomeric-OH, abolished agonist activity at TRPM2.	Ribose	52-58	transient receptor potential cation channel subfamily M member 2	Homo sapiens	169-174
28515263-8	2017	Taken together, using the complementary experimental approaches of chemical modification of the ligand and site-directed mutagenesis of TRPM2, we demonstrate that channel activation critically depends on hydrogen bonding of Arg1433 and Tyr1349 with the terminal ribose.	Ribose	262-268	transient receptor potential cation channel subfamily M member 2	Homo sapiens	136-141
28257177-5	2017	Previously we described mechanistically how glycation of hen egg-white lysozyme (HEWL) with ribose induced its aggregation.	Ribose	92-98	lysozyme	Homo sapiens	71-79
28462838-5	2017	The cellular uptake studies suggested that ribose-modified compound 9 could be taken through GLUT1 in A549 cell line.	Ribose	43-49	solute carrier family 2 member 1	Homo sapiens	93-98
28515149-8	2017	13C-flux analysis showed that Pkm2 deletion reduced the flow of glucose carbons into lactate and glutamate without markedly increasing glucose-to-ribose flux.	Ribose	146-152	pyruvate kinase, muscle	Mus musculus	30-34
28002403-5	2017	Indeed, remarkably, genetic deletion of Parp1 rescued normal cerebellar ADP-ribose levels and reduced the loss of cerebellar neurons and ataxia in Xrcc1-defective mice, identifying a molecular mechanism by which endogenous single-strand breaks trigger neuropathology.	Ribose	76-82	poly (ADP-ribose) polymerase family, member 1	Mus musculus	40-45
28319392-7	2017	Ribose analogues were weaker in DAT interaction than the corresponding bicyclics.	Ribose	0-6	solute carrier family 6 member 3	Homo sapiens	32-35
27561427-1	2017	BACKGROUND: This study analyzes effect of glycation on ApoB-100 residues by D-ribose as D-ribosylated-glycated LDL might be responsible for the cause of diabetes mellitus because of its far higher antigenic ability.	Ribose	76-84	apolipoprotein B	Homo sapiens	55-63
28143925-5	2017	Here, we demonstrated that the CHIKV nsP3 macrodomain is able to hydrolyze ADP-ribose groups from mono(ADP-ribosyl)ated proteins.	Ribose	79-85	SH2 domain containing 3C	Homo sapiens	37-41
28150709-7	2017	In contrast, the viral macrodomains possess only weak activity towards poly-ADP-ribose chains synthesized by ARTD1 (aka PARP1).	Ribose	80-86	poly(ADP-ribose) polymerase 1	Homo sapiens	109-114
28150709-7	2017	In contrast, the viral macrodomains possess only weak activity towards poly-ADP-ribose chains synthesized by ARTD1 (aka PARP1).	Ribose	80-86	poly(ADP-ribose) polymerase 1	Homo sapiens	120-125
28432356-7	2017	Rpp29 and Rpp21 bind poly ADP-ribose moieties and are recruited to DNA damage sites in a PARP1-dependent manner.	Ribose	30-36	POP4 homolog, ribonuclease P/MRP subunit	Homo sapiens	0-5
28432356-7	2017	Rpp29 and Rpp21 bind poly ADP-ribose moieties and are recruited to DNA damage sites in a PARP1-dependent manner.	Ribose	30-36	ribonuclease P/MRP subunit p21	Homo sapiens	10-15
28432356-7	2017	Rpp29 and Rpp21 bind poly ADP-ribose moieties and are recruited to DNA damage sites in a PARP1-dependent manner.	Ribose	30-36	poly(ADP-ribose) polymerase 1	Homo sapiens	89-94
28254166-1	2017	We report the design and synthesis of a series of novel Bruton"s Tyrosine Kinase (BTK) inhibitors with a carboxylic acid moiety in the ribose pocket.	Ribose	135-141	Bruton tyrosine kinase	Homo sapiens	56-80
28254166-1	2017	We report the design and synthesis of a series of novel Bruton"s Tyrosine Kinase (BTK) inhibitors with a carboxylic acid moiety in the ribose pocket.	Ribose	135-141	Bruton tyrosine kinase	Homo sapiens	82-85
28257697-2	2017	(2017) demonstrate that histone PARylation factor 1 (HPF1) is required for PARP1 to attach ADP-ribose groups onto the hydroxyl oxygen of the Ser residues of target substrates, including both PARP1 itself and histones.	Ribose	95-101	histone PARylation factor 1	Homo sapiens	24-51
28257697-2	2017	(2017) demonstrate that histone PARylation factor 1 (HPF1) is required for PARP1 to attach ADP-ribose groups onto the hydroxyl oxygen of the Ser residues of target substrates, including both PARP1 itself and histones.	Ribose	95-101	histone PARylation factor 1	Homo sapiens	53-57
28257697-2	2017	(2017) demonstrate that histone PARylation factor 1 (HPF1) is required for PARP1 to attach ADP-ribose groups onto the hydroxyl oxygen of the Ser residues of target substrates, including both PARP1 itself and histones.	Ribose	95-101	poly(ADP-ribose) polymerase 1	Homo sapiens	75-80
28040055-7	2016	Besides, the effects of carbohydrates such as sucrose, fructose, ribose and glucose on PPO activity were investigated.	Ribose	65-71	Polyphenol oxidase, chloroplastic	Zea mays	87-90
27790731-9	2016	Specifically, metabolites from the nucleotide and amino acid pathway (ribose, glucose-6-phosphate, glutamic acid, aspartic acid, and sedoheptulose-7-P) were elevated in Shp-/- CD + M mice during the dark cycle, whereas metabolites including N-methylalanine, 2-hydroxybutyric acid, and 2-hydroxyglutarate were elevated in WT ED + E mice during the light cycle.	Ribose	70-76	nuclear receptor subfamily 0, group B, member 2	Mus musculus	169-172
27510652-2	2016	Adenosine diphosphate (ADP)-ribosylation is a post-translational modification reaction that catalyzes the transfer of ADP-ribose group to eEF2 and this causes the inhibition of protein synthesis.	Ribose	122-128	eukaryotic translation elongation factor 2	Homo sapiens	138-142
28695501-2	2017	PARP catalyzes the addition of ADP-ribose molecules (pADPr) to the target proteins, a process termed poly-ADP-ribosylation.	Ribose	35-41	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
28695507-1	2017	The PARP family of ADP-ribosyl transferases contains 17 members in human cells, most of which catalyze the transfer of the ADP-ribose moiety of NAD+ onto their target proteins.	Ribose	127-133	poly(ADP-ribose) polymerase 1	Homo sapiens	4-8
27872485-7	2016	DEX effectively reversed capsaicin and cumene hydroperoxide/ADP-ribose-induced TRPV1 and TRPM2 densities and cytosolic calcium ion accumulation in the neurons, respectively.	Ribose	64-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	79-84
27471034-4	2016	PARP1 preferentially catalysed covalent attachment of ADP-ribose units to the ends of recessed DNA duplexes containing 3"-cordycepin, 5"- and 3"-phosphate and also to 5"-phosphate of a single-stranded oligonucleotide.	Ribose	58-64	poly(ADP-ribose) polymerase 1	Homo sapiens	0-5
27471034-7	2016	Biochemical and mass spectrometry analyses of the adducts suggested that PARPs utilise DNA termini as an alternative to 2"-hydroxyl of ADP-ribose and protein acceptor residues to catalyse PAR chain initiation either via the 2",1""-O-glycosidic ribose-ribose bond or via phosphodiester bond formation between C1" of ADP-ribose and the phosphate of a terminal deoxyribonucleotide.	Ribose	139-145	poly(ADP-ribose) polymerase 1	Homo sapiens	73-78
27471034-7	2016	Biochemical and mass spectrometry analyses of the adducts suggested that PARPs utilise DNA termini as an alternative to 2"-hydroxyl of ADP-ribose and protein acceptor residues to catalyse PAR chain initiation either via the 2",1""-O-glycosidic ribose-ribose bond or via phosphodiester bond formation between C1" of ADP-ribose and the phosphate of a terminal deoxyribonucleotide.	Ribose	244-250	poly(ADP-ribose) polymerase 1	Homo sapiens	73-78
27601466-1	2016	Ribose can be used for energy or as a component of several important biomolecules, but for it to be used in either capacity it must first be phosphorylated by ribokinase (RBSK).	Ribose	0-6	ribokinase	Homo sapiens	171-175
27601466-10	2016	Ribose accumulation in plants lacking AtRBSK was reduced in plants also deficient in the nucleoside ribohydrolase NSH1, linking AtRBSK activity to nucleoside metabolism.	Ribose	0-6	uridine-ribohydrolase 1	Arabidopsis thaliana	114-118
27594684-0	2016	Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.	Ribose	82-88	tankyrase	Homo sapiens	0-11
26446934-2	2016	Due to these proven AICAR properties, we have designed, synthesized and tested the biological activity of two ribose-modified AICAR derivatives, named A3 and A4, in comparison to native AICAR and its 5"-phosphorylated counterpart ZMP.	Ribose	110-116	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	20-25
26446934-2	2016	Due to these proven AICAR properties, we have designed, synthesized and tested the biological activity of two ribose-modified AICAR derivatives, named A3 and A4, in comparison to native AICAR and its 5"-phosphorylated counterpart ZMP.	Ribose	110-116	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	126-131
26446934-2	2016	Due to these proven AICAR properties, we have designed, synthesized and tested the biological activity of two ribose-modified AICAR derivatives, named A3 and A4, in comparison to native AICAR and its 5"-phosphorylated counterpart ZMP.	Ribose	110-116	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	126-131
27872485-7	2016	DEX effectively reversed capsaicin and cumene hydroperoxide/ADP-ribose-induced TRPV1 and TRPM2 densities and cytosolic calcium ion accumulation in the neurons, respectively.	Ribose	64-70	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	89-94
27351669-6	2016	Protein intrinsic fluorescence showed marked conformational changes when BLC was incubated with D-ribose, glucose and fructose.	Ribose	96-104	C-X-C motif chemokine ligand 13	Homo sapiens	73-76
27695694-6	2016	To this aim, the glycation kinetics of both native and demetalated SOD have been followed using two different glycating agents, i.e., D-ribose and methylglyoxal.	Ribose	134-142	superoxide dismutase 1	Homo sapiens	67-70
27635653-1	2016	The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage.	Ribose	74-80	AFG3-like AAA ATPase 2	Mus musculus	82-85
27635653-1	2016	The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage.	Ribose	74-80	poly (ADP-ribose) polymerase family, member 1	Mus musculus	118-147
27635653-1	2016	The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage.	Ribose	74-80	poly (ADP-ribose) polymerase family, member 1	Mus musculus	149-154
27618067-2	2016	The second member of the transient receptor potential (TRP) melastatin subfamily, TRPM2, is a Ca(2+)-permeable non-selective cation channel, activated by ROS in an ADP-ribose mediated fashion.	Ribose	168-174	transient receptor potential cation channel subfamily M member 2	Homo sapiens	82-87
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	175-181	poly(ADP-ribose) glycohydrolase	Homo sapiens	80-84
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	175-181	N-myc downstream regulated 1	Homo sapiens	86-91
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	175-181	mono-ADP ribosylhydrolase 1	Homo sapiens	93-100
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	175-181	mono-ADP ribosylhydrolase 2	Homo sapiens	105-112
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	209-215	poly(ADP-ribose) glycohydrolase	Homo sapiens	80-84
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	209-215	N-myc downstream regulated 1	Homo sapiens	86-91
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	209-215	mono-ADP ribosylhydrolase 1	Homo sapiens	93-100
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	209-215	mono-ADP ribosylhydrolase 2	Homo sapiens	105-112
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	209-215	poly(ADP-ribose) glycohydrolase	Homo sapiens	80-84
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	209-215	N-myc downstream regulated 1	Homo sapiens	86-91
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	209-215	mono-ADP ribosylhydrolase 1	Homo sapiens	93-100
27406238-3	2016	Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose).	Ribose	209-215	mono-ADP ribosylhydrolase 2	Homo sapiens	105-112
27406238-8	2016	We also demonstrate the utility of ENPP1 for converting protein-conjugated mono(ADP-ribose) and poly(ADP-ribose) into mass spectrometry-friendly pR tags, thus facilitating the identification of ADP-ribosylation sites.	Ribose	84-90	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	35-40
27351669-7	2016	Glycation with D-ribose induces BLC to misfold rapidly into an intermediate state retaining a low percentage of alpha-helical content compared to fructose and glucose as revealed by far-UV CD data.	Ribose	15-23	C-X-C motif chemokine ligand 13	Homo sapiens	32-35
26234903-2	2015	The preliminary ex vivo cytokine profiling revealed optimal Th1 activation and the in vivo adjuvant studies of ribose derived hybrid (6 e) revealed a marked improvement in the OVA specific antibody IgG response and Th1 cytokine expressions.	Ribose	111-117	negative elongation factor complex member C/D	Homo sapiens	215-218
26481663-6	2015	Unexpectedly, PEPCK also increased the synthesis of ribose from non-carbohydrate sources, such as glutamine, a phenomenon not previously described.	Ribose	52-58	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	14-19
27136943-3	2016	We now report the generation of bias "fingerprints" for prototypical ribose containing A3AR agonists and rigidified (N)-methanocarba 5"-N-methyluronamide nucleoside derivatives with regard to their ability to mediate different signaling pathways.	Ribose	69-75	adenosine A3 receptor	Homo sapiens	87-91
26325019-3	2016	Hemoglobin and bovine serum albumin (BSA) were glycated with glucose, fructose, and ribose in the presence and absence of Asp (100-200 muM).	Ribose	84-90	albumin	Homo sapiens	22-35
27194947-5	2016	Ribokinase, which is encoded by Rbks gene, is the first enzyme for ribose metabolism in vivo.	Ribose	67-73	ribokinase	Mus musculus	0-10
27194947-5	2016	Ribokinase, which is encoded by Rbks gene, is the first enzyme for ribose metabolism in vivo.	Ribose	67-73	ribokinase	Mus musculus	32-36
27194947-6	2016	Rbks mutation resulted in ribose accumulation in the small intestine, which accelerated gut movement.	Ribose	26-32	ribokinase	Mus musculus	0-4
26934315-1	2016	Poly (ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose groups to target proteins and are involved in a variety of biological processes.	Ribose	10-16	poly(ADP-ribose) polymerase family member 6	Homo sapiens	31-36
26927423-5	2016	Concurrent crystallography-driven exploration of the ribose pocket and the solvent front led to analogs with optimized kinome and JAK1 selectivities over the JAK2 isoform by targeting several residues unique to JAK1, such as Arg-879 and Glu-966.	Ribose	53-59	Janus kinase 1	Homo sapiens	130-134
26927423-5	2016	Concurrent crystallography-driven exploration of the ribose pocket and the solvent front led to analogs with optimized kinome and JAK1 selectivities over the JAK2 isoform by targeting several residues unique to JAK1, such as Arg-879 and Glu-966.	Ribose	53-59	Janus kinase 2	Homo sapiens	158-162
26927423-5	2016	Concurrent crystallography-driven exploration of the ribose pocket and the solvent front led to analogs with optimized kinome and JAK1 selectivities over the JAK2 isoform by targeting several residues unique to JAK1, such as Arg-879 and Glu-966.	Ribose	53-59	Janus kinase 1	Homo sapiens	211-215
26878265-6	2016	That ribose conformations and base types have different propensities for anti or syn glycosidic conformations further affects the overall flexibility of CDNs.	Ribose	5-11	synemin	Homo sapiens	81-84
26383629-4	2016	Upon induction of specific forms of genotoxic stimuli, several poly(ADP-ribose) polymerases (PARPs) synthesize the nucleic acid-like biopolymer poly(ADP-ribose) (PAR) by using NAD(+) as a substrate.	Ribose	72-79	poly(ADP-ribose) polymerase 1	Homo sapiens	93-98
26519138-0	2016	D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts.	Ribose	0-8	insulin	Homo sapiens	22-29
26350612-4	2015	METHODS: oxPTM of insulin was generated using ribose and various reactive oxygen species.	Ribose	46-52	insulin	Homo sapiens	18-25
26365067-2	2015	The glycation of Ribonuclease A (RNase A) at pH 7.4 and 37  C with ribose, glucose and fructose has been monitored by UV-vis, fluorescence, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and matrix assisted laser desorption ionization spectroscopy-time of flight (MALDI-TOF) methods.	Ribose	67-73	ribonuclease A family member 1, pancreatic	Homo sapiens	17-31
26365067-2	2015	The glycation of Ribonuclease A (RNase A) at pH 7.4 and 37  C with ribose, glucose and fructose has been monitored by UV-vis, fluorescence, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and matrix assisted laser desorption ionization spectroscopy-time of flight (MALDI-TOF) methods.	Ribose	67-73	ribonuclease A family member 1, pancreatic	Homo sapiens	33-40
26605136-2	2015	The crystal structure of Rhodobacter capsulatus ALAS indicates that the adenosyl moiety of succinyl-CoA is positioned in a mainly hydrophobic pocket, where the ribose group forms a putative hydrogen bond with Lys156.	Ribose	160-166	aminolevulinic acid synthase 2, erythroid	Mus musculus	48-52
26298499-3	2015	With the two methoxypyridine groups selected to occupy the affinity pocket, analogs were prepared with various fragments intended to occupy the ribose pocket of PI3Kalpha and mTOR.	Ribose	144-150	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	161-170
28455045-2	2015	Reducing sugars, xylose, ribose, fructose, glucose, and non-reducing sucrose were reacted with glycine (Xyl-Gly, Rib-Gly, Fru-Gly, Glc-Gly, and Suc-Gly), or lysine (Xyl-Lys, Rib-Lys, Fru-Lys, Glc-Lys, and Suc-Lys), respectively, at temperatures of 150 C and 180 C for time periods ranging from 5 to 60min.	Ribose	25-31	zinc finger and BTB domain containing 22	Homo sapiens	122-125
25934335-6	2015	Labeling of the ribose ring demonstrates that U87-MG glioma cells use the reversible branch of the non-oxidative pentose phosphate pathway.	Ribose	16-22	small nucleolar RNA, C/D box 87	Homo sapiens	46-49
26226322-7	2015	Instead, we present a completely different reaction mechanism, where hOGG1 initially targets the ribose moiety of the substrate and cleaves the glycosidic bond at the very last stage.	Ribose	97-103	8-oxoguanine DNA glycosylase	Homo sapiens	69-74
26091901-3	2015	HPLC analysis showed that PAP consisted of D-mannose, D-ribose, l-rhamnose, D-glucuronic acid, D-glucose and D-galactose, and their corresponding mole percentages were 3.4%, 1.1%, 1.9%, 1.4%, 87.9% and 4.4%, respectively.	Ribose	54-62	regenerating family member 3 alpha	Homo sapiens	26-29
26226322-8	2015	Our ribose-protonated repair mechanism is not only energetically more preferable, but also explains the selectivity utilized by hOGG1 to block processing a guanine base.	Ribose	4-10	8-oxoguanine DNA glycosylase	Homo sapiens	128-133
26942084-5	2016	PARP enzymes catalytically cleave beta-NAD+ and transfer the ADP-ribose moiety to acceptor proteins, modifying their function.	Ribose	65-71	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
25928429-5	2015	Knockdown of TIGAR exacerbated DNA damage and the effects were partly reversed by the supplementation of PPP products NADPH, ribose, or the ROS scavenger NAC.	Ribose	125-131	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	13-18
26086917-4	2015	Here, we developed a novel strategy for comprehensive profiling of ribose conjugates from biological fluids using metal oxide-based dispersive solid-phase extraction (DSPE) followed with in vitro stable isotope labeling and double neutral loss scan-mass spectrometry analysis (DSPE-SIL-LC-DNLS-MS).	Ribose	67-73	STIL centriolar assembly protein	Homo sapiens	282-285
26086917-10	2015	Using the developed DSPE-SIL-LC-DNLS-MS strategy, we profiled the ribose conjugates in human urine, and 49 ribose conjugates were readily identified, among which 7 ribose conjugates exhibited significant contents change between healthy controls and lymphoma patients.	Ribose	66-72	STIL centriolar assembly protein	Homo sapiens	25-28
26086917-11	2015	The DSPE-SIL-LC-DNLS-MS strategy combines the selective enrichment, stable isotope labeling, and double neutral loss scan - MS analysis, which therefore can efficiently minimize false positive results, facilitate the relative quantification, and notably increase the numbers of identified ribose conjugates in biological fluids samples.	Ribose	289-295	STIL centriolar assembly protein	Homo sapiens	9-12
25636209-7	2015	RESULTS: ID1-4 expression was upregulated in vivo in the islets of diabetic db/db mice and stimulated in vitro by ribose and H2O2.	Ribose	114-120	inhibitor of DNA binding 1, HLH protein	Mus musculus	9-12
25128692-2	2015	Here we show that the mammalian mono-ADP-ribosyltransferase-1 (ART1), which selectively transfers the ADP-ribose moiety from NAD to arginine residues, ADP-ribosylates LL-37 in vitro.	Ribose	106-112	ADP-ribosyltransferase 1	Homo sapiens	32-61
25128692-2	2015	Here we show that the mammalian mono-ADP-ribosyltransferase-1 (ART1), which selectively transfers the ADP-ribose moiety from NAD to arginine residues, ADP-ribosylates LL-37 in vitro.	Ribose	106-112	ADP-ribosyltransferase 1	Homo sapiens	63-67
25128692-2	2015	Here we show that the mammalian mono-ADP-ribosyltransferase-1 (ART1), which selectively transfers the ADP-ribose moiety from NAD to arginine residues, ADP-ribosylates LL-37 in vitro.	Ribose	106-112	cathelicidin antimicrobial peptide	Homo sapiens	167-172
25128692-5	2015	The attachment of negatively charged ADP-ribose moieties considerably alters the positive charge of the arginine residues thus reducing the cationicity of LL-37.	Ribose	41-47	cathelicidin antimicrobial peptide	Homo sapiens	155-160
25800440-3	2015	By monitoring spectral counts of specific hydroxamic acid signatures generated after the conversion of the ADP-ribose modification onto peptides by hydroxylamine hydrolysis, we undertook a thorough mass spectrometry mapping of the glutamate and aspartate ADP-ribosylation sites onto automodified PARP-1, PARP-2 and PARP-3.	Ribose	111-117	poly(ADP-ribose) polymerase 1	Homo sapiens	296-302
25800440-3	2015	By monitoring spectral counts of specific hydroxamic acid signatures generated after the conversion of the ADP-ribose modification onto peptides by hydroxylamine hydrolysis, we undertook a thorough mass spectrometry mapping of the glutamate and aspartate ADP-ribosylation sites onto automodified PARP-1, PARP-2 and PARP-3.	Ribose	111-117	poly(ADP-ribose) polymerase 2	Homo sapiens	304-310
25800440-3	2015	By monitoring spectral counts of specific hydroxamic acid signatures generated after the conversion of the ADP-ribose modification onto peptides by hydroxylamine hydrolysis, we undertook a thorough mass spectrometry mapping of the glutamate and aspartate ADP-ribosylation sites onto automodified PARP-1, PARP-2 and PARP-3.	Ribose	111-117	poly(ADP-ribose) polymerase family member 3	Homo sapiens	315-321
26759810-0	2015	Improvement of D-Ribose Production from Corn Starch Hydrolysate by a Transketolase-Deficient Strain Bacillus subtilis UJS0717.	Ribose	15-23	Transketolase, chloroplastic	Zea mays	69-82
25653162-5	2015	Furthermore, we identified snR40 as being responsible to guide snoRNP complex to catalyze G562 ribose methylation, which makes it only second snoRNA known so far to target three ribose methylation sites: Gm562, Gm1271 in 18S rRNA, and Um898 in 25S rRNA.	Ribose	95-101	SNR40	Saccharomyces cerevisiae S288C	27-32
25653162-5	2015	Furthermore, we identified snR40 as being responsible to guide snoRNP complex to catalyze G562 ribose methylation, which makes it only second snoRNA known so far to target three ribose methylation sites: Gm562, Gm1271 in 18S rRNA, and Um898 in 25S rRNA.	Ribose	178-184	SNR40	Saccharomyces cerevisiae S288C	27-32
24825450-3	2015	The strong hydrogen bonding with Glu234 and hydrophobic interactions with several residues, namely Leu156, Gly157, Val164, Ala177, Tyr229, Ala230, Met281 and Thr291, at the vicinity which is normally occupied by the ribose of ATP, appear to be the main causes of Akt1 inhibition and lead to the significant conformational change on this region of protein.	Ribose	216-222	AKT serine/threonine kinase 1	Homo sapiens	263-267
24797673-7	2015	Glucose-injected chicks had higher expression of IL-6 or IL-10, while those injected with fructose or ribose had higher expression of IL-2, IL-12 and IFN gamma.	Ribose	102-108	interleukin 15	Gallus gallus	134-138
24797673-7	2015	Glucose-injected chicks had higher expression of IL-6 or IL-10, while those injected with fructose or ribose had higher expression of IL-2, IL-12 and IFN gamma.	Ribose	102-108	interleukin-12 subunit alpha	Ovis aries	140-145
24797673-7	2015	Glucose-injected chicks had higher expression of IL-6 or IL-10, while those injected with fructose or ribose had higher expression of IL-2, IL-12 and IFN gamma.	Ribose	102-108	interferon gamma	Gallus gallus	150-159
24990614-5	2015	Through the enzymatic conversion of NAD into ADPR (ADP-ribose) and cADPR (cyclic ADP-ribose), CD38 increases cytoplasmic Ca(2+) concentrations, positively influencing proliferation and signaling mediated via chemokine receptors or integrins.	Ribose	55-61	CD38 molecule	Homo sapiens	94-98
24990614-5	2015	Through the enzymatic conversion of NAD into ADPR (ADP-ribose) and cADPR (cyclic ADP-ribose), CD38 increases cytoplasmic Ca(2+) concentrations, positively influencing proliferation and signaling mediated via chemokine receptors or integrins.	Ribose	85-91	CD38 molecule	Homo sapiens	94-98
25893083-10	2015	Poly(ADP-ribose) glycohydrolase hydrolyzes PAR polymers into ADP-ribose molecules, which translocate to plasma membranes, activating melastatin-like transient receptor potential 2 (TRPM-2) channels, which open, allowing Ca(2 +) influx into neurons.	Ribose	9-15	transient receptor potential cation channel subfamily M member 2	Homo sapiens	181-187
25879940-2	2015	Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel gated by ADP-ribose (ADPR).	Ribose	99-106	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	0-41
25879940-2	2015	Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel gated by ADP-ribose (ADPR).	Ribose	99-106	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	43-48
25706250-3	2015	Here we describe the chemical synthesis of the ADP-ribose dimer, and we use this compound to obtain the first human PARG substrate-enzyme cocrystal structure.	Ribose	51-57	poly(ADP-ribose) glycohydrolase	Homo sapiens	116-120
25463112-11	2014	CONCLUSIONS: As ribose-cysteine lowers LDL, Lp(a) and oxidised lipid concentrations, it might be an ideal intervention to increase protection against the development of atherosclerosis.	Ribose	16-22	lipoprotein(a)	Homo sapiens	44-49
25473284-0	2014	Inhibitory effect of gold nanoparticles on the D-ribose glycation of bovine serum albumin.	Ribose	49-55	albumin	Homo sapiens	76-89
25473284-2	2014	This study describes the inhibitory effect of gold nanoparticles (GNPs) on the D-ribose glycation of bovine serum albumin (BSA).	Ribose	79-87	albumin	Homo sapiens	108-121
25057908-7	2014	Moreover, lysozyme incubated with ribose reduces the viability of SH-SY5Y neuroblastoma cells.	Ribose	34-40	lysozyme	Homo sapiens	10-18
25293769-3	2014	Poly(adenosine 5"-diphosphate [ADP]-ribose)-polymerase (PARP)-14 belongs to a family of intracellular proteins that generate ADP-ribose posttranslational adducts.	Ribose	36-42	poly (ADP-ribose) polymerase family, member 14	Mus musculus	56-64
25226087-0	2014	Cyclic adenosine 5"-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.	Ribose	32-38	CD38 molecule	Homo sapiens	113-117
25226087-2	2014	Replacing the base N9-ribose with a butyl chain generates inhibitors of cADPR hydrolysis by the human ADP-ribosyl cyclase CD38 catalytic domain (shCD38), illustrating the nonessential nature of the "southern" ribose for binding.	Ribose	22-28	CD38 molecule	Homo sapiens	122-126
25226087-6	2014	Taken together, these analogs confirm that the "northern" ribose is critical for CD38 activity and inhibition, provide new insight into the mechanism of cADPR hydrolysis by CD38, and may aid future inhibitor design.	Ribose	58-64	CD38 molecule	Homo sapiens	81-85
25226087-6	2014	Taken together, these analogs confirm that the "northern" ribose is critical for CD38 activity and inhibition, provide new insight into the mechanism of cADPR hydrolysis by CD38, and may aid future inhibitor design.	Ribose	58-64	CD38 molecule	Homo sapiens	173-177
25332845-1	2014	Poly-ADP-ribose (PAR) is a polymer of up to 400 ADP-ribose units synthesized by poly-ADP-ribose-polymerases (PARPs) and degraded by poly-ADP-ribose-glycohydrolase (PARG).	Ribose	9-15	poly(ADP-ribose) glycohydrolase	Chlorocebus sabaeus	132-162
25332845-1	2014	Poly-ADP-ribose (PAR) is a polymer of up to 400 ADP-ribose units synthesized by poly-ADP-ribose-polymerases (PARPs) and degraded by poly-ADP-ribose-glycohydrolase (PARG).	Ribose	9-15	poly(ADP-ribose) glycohydrolase	Chlorocebus sabaeus	164-168
24865146-4	2014	Hydrolytic activity of macrodomain proteins (MacroD1, MacroD2 and TARG1) is responsible for the removal of terminal ADP-ribose unit and for complete reversion of protein ADP-ribosylation.	Ribose	120-126	mono-ADP ribosylhydrolase 1	Homo sapiens	45-52
24865146-4	2014	Hydrolytic activity of macrodomain proteins (MacroD1, MacroD2 and TARG1) is responsible for the removal of terminal ADP-ribose unit and for complete reversion of protein ADP-ribosylation.	Ribose	120-126	mono-ADP ribosylhydrolase 2	Homo sapiens	54-61
24865146-4	2014	Hydrolytic activity of macrodomain proteins (MacroD1, MacroD2 and TARG1) is responsible for the removal of terminal ADP-ribose unit and for complete reversion of protein ADP-ribosylation.	Ribose	120-126	O-acyl-ADP-ribose deacylase 1	Homo sapiens	66-71
24604252-3	2014	The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively.	Ribose	210-216	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	12-65
24604252-3	2014	The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively.	Ribose	210-216	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	67-73
24604252-3	2014	The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively.	Ribose	210-216	glutaminase	Homo sapiens	79-92
24604252-3	2014	The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively.	Ribose	210-216	glutaminase	Homo sapiens	94-98
24861463-7	2014	Here, we determined that G6PD, NADPH and ribose synthesis were all increased by AR signaling.	Ribose	41-47	androgen receptor	Homo sapiens	80-82
24954297-2	2014	Using enzymes from the pentose phosphate pathway, we coupled chemically synthesized uracil nucleobase with specifically (13) C-labeled ribose to synthesize both UTP and CTP in nearly quantitative yields.	Ribose	135-141	solute carrier family 25 member 1	Homo sapiens	169-172
24982199-2	2014	Here, we develop and validate a novel PET probe, [(18)F]-2-deoxy-2-fluoroarabinose ([(18)F]DFA), for in vivo imaging of ribose salvage.	Ribose	120-126	thyroid stimulating hormone receptor	Mus musculus	38-41