PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 12493848-5 2003 Both hyoscyamine and scopolamine production were improved in hairy root cultures of D. metel, whereas in H. muticus only hyoscyamine contents were increased by pmt gene overexpression. Hyoscyamine 121-132 putrescine N-methyltransferase 3 Nicotiana tabacum 160-163 22546652-7 2012 Hyoscyamine induced caspase-3 mediated apoptosis. Hyoscyamine 0-11 caspase 3 Homo sapiens 20-29 22546652-8 2012 Up regulation of p53 gene expression provides cue for apoptotic activity of hyoscyamine. Hyoscyamine 76-87 tumor protein p53 Homo sapiens 17-20 16845528-1 2006 Tropinone reductases (TRs) are essential enzymes in the tropane alkaloid biosynthesis, providing either tropine for hyoscyamine and scopolamine formation or providing pseudotropine for calystegines. Hyoscyamine 116-127 tropinone reductase 1-like Solanum tuberosum 0-20 16845528-3 2006 One reductase formed pseudotropine, the other formed tropine and showed kinetic properties typical for tropine-forming tropinone reductases (TRI) involved in hyoscyamine formation. Hyoscyamine 158-169 tropinone reductase 1-like Solanum tuberosum 119-139 16845528-3 2006 One reductase formed pseudotropine, the other formed tropine and showed kinetic properties typical for tropine-forming tropinone reductases (TRI) involved in hyoscyamine formation. Hyoscyamine 158-169 tropinone reductase 1-like Solanum tuberosum 141-144 17004056-4 2007 The results indicate that hairy root lines over-expressing pmt have a high capacity to synthesize MPUT, whereas their ability to convert hyoscyamine into scopolamine is very limited. Hyoscyamine 137-148 putrescine N-methyltransferase 1 Nicotiana tabacum 59-62