PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15757502-0 2005 Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). Phenylephrine 76-89 mitogen-activated protein kinase 1 Homo sapiens 117-120 15757502-0 2005 Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). Phenylephrine 76-89 TSC complex subunit 2 Homo sapiens 183-187 15757502-6 2005 PE stimulation of cardiomyocytes induced the phosphorylation of TSC2 (tuberous sclerosis complex 2), a negative regulator of mTOR activity. Phenylephrine 0-2 TSC complex subunit 2 Homo sapiens 64-68 15757502-6 2005 PE stimulation of cardiomyocytes induced the phosphorylation of TSC2 (tuberous sclerosis complex 2), a negative regulator of mTOR activity. Phenylephrine 0-2 mechanistic target of rapamycin kinase Homo sapiens 125-129 15757502-11 2005 Inhibition of the MAPK-interacting kinases by CGP57380 decreases the phosphorylation of eIF4E and PE-induced protein synthesis. CGP 57380 46-54 eukaryotic translation initiation factor 4E Homo sapiens 88-93 20823585-5 2010 Furthermore, IPA was found to induce the loss of mitochondrial membrane potential, the release of cytochrome c to the cytosol, and the increased ratio of mitochondrial Bax/Bcl-2. ipa 13-16 cytochrome c, somatic Homo sapiens 98-110 20823585-5 2010 Furthermore, IPA was found to induce the loss of mitochondrial membrane potential, the release of cytochrome c to the cytosol, and the increased ratio of mitochondrial Bax/Bcl-2. ipa 13-16 BCL2 associated X, apoptosis regulator Homo sapiens 168-171 20823585-5 2010 Furthermore, IPA was found to induce the loss of mitochondrial membrane potential, the release of cytochrome c to the cytosol, and the increased ratio of mitochondrial Bax/Bcl-2. ipa 13-16 BCL2 apoptosis regulator Homo sapiens 172-177 20823585-6 2010 Moreover, we demonstrated that IPA triggered endoplasmic reticulum (ER) stress, as shown by changes in cytosol-calcium level, activation of mu-calpain and caspase-12, and up-regulation of glucose-regulated protein 78 (GRP78) and growth arrest DNA damage-inducible gene 153 (GADD153). ipa 31-34 heat shock protein family A (Hsp70) member 5 Homo sapiens 188-216 20823585-6 2010 Moreover, we demonstrated that IPA triggered endoplasmic reticulum (ER) stress, as shown by changes in cytosol-calcium level, activation of mu-calpain and caspase-12, and up-regulation of glucose-regulated protein 78 (GRP78) and growth arrest DNA damage-inducible gene 153 (GADD153). ipa 31-34 heat shock protein family A (Hsp70) member 5 Homo sapiens 218-223 18979361-8 2008 IPA and ATP release remain stable for at least 32 h when whole blood is anticoagulated with a dual inhibitor of factor Xa and thrombin. ipa 0-3 coagulation factor II, thrombin Homo sapiens 126-134 10419516-6 1999 IPA completely protected primary neurons and neuroblastoma cells against oxidative damage and death caused by exposure to Abeta, by inhibition of superoxide dismutase, or by treatment with hydrogen peroxide. ipa 0-3 amyloid beta precursor protein Homo sapiens 122-127 34966655-3 2021 The current study aimed to investigate the role of IPA in carbon tetrachloride (CCl4)-induced liver fibrosis and explore the underlying mechanisms. ipa 51-54 chemokine (C-C motif) ligand 4 Mus musculus 80-84 34915193-3 2022 Also, IPA mitigated CPF-mediated diminution in cholinergic and antioxidant defense systems whereas it markedly improved thioredoxin level and thioredoxin reductase activity in cerebral and cerebellar tissues of the animals. ipa 6-9 thioredoxin 1 Rattus norvegicus 120-131 34915193-3 2022 Also, IPA mitigated CPF-mediated diminution in cholinergic and antioxidant defense systems whereas it markedly improved thioredoxin level and thioredoxin reductase activity in cerebral and cerebellar tissues of the animals. ipa 6-9 thioredoxin 1 Rattus norvegicus 142-153 34915193-4 2022 Co-administration of IPA significantly enhanced anti-inflammatory cytokine, interleukin-10 but suppressed oxidative and inflammatory stress, caspase-9 and caspase-3 activation with concomitant reduction in 8-hydroxy-2"-deoxyguanosine (8-OHdG) level and histological damage. ipa 21-24 interleukin 10 Rattus norvegicus 76-90 34915193-4 2022 Co-administration of IPA significantly enhanced anti-inflammatory cytokine, interleukin-10 but suppressed oxidative and inflammatory stress, caspase-9 and caspase-3 activation with concomitant reduction in 8-hydroxy-2"-deoxyguanosine (8-OHdG) level and histological damage. ipa 21-24 caspase 9 Rattus norvegicus 141-150 34915193-4 2022 Co-administration of IPA significantly enhanced anti-inflammatory cytokine, interleukin-10 but suppressed oxidative and inflammatory stress, caspase-9 and caspase-3 activation with concomitant reduction in 8-hydroxy-2"-deoxyguanosine (8-OHdG) level and histological damage. ipa 21-24 caspase 3 Rattus norvegicus 155-164 9208148-7 1997 Both the ETB antagonist, BQ788 (3 microM) and or endothelium denudation, but not the ETA antagonist, BQ123 (3 microM), abolished the vasodilation induced by ET-1 or ET-3 (100 nM each) in EPA and in IPA. ipa 198-201 endothelin receptor type B Rattus norvegicus 9-12 9208148-11 1997 Furthermore, ETB-mediated vasodilatation involves activation of ATP-sensitive K+ channels and of nitric oxide synthase in rat isolated EPA and IPA. ipa 143-146 endothelin receptor type B Rattus norvegicus 13-16 34966655-11 2021 Results: After IPA treatment, the ALT and AST, apoptotic cells, and pro-inflammatory factor levels were enhanced significantly. ipa 15-18 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 42-45 34966655-15 2021 Conclusions: IPA aggravated CCl4-induced liver damage and fibrosis by activating HSCs via the TGF-beta1/Smads signaling pathway. ipa 13-16 chemokine (C-C motif) ligand 4 Mus musculus 28-32 34966655-15 2021 Conclusions: IPA aggravated CCl4-induced liver damage and fibrosis by activating HSCs via the TGF-beta1/Smads signaling pathway. ipa 13-16 transforming growth factor, beta 1 Mus musculus 94-103 34830317-7 2021 Subsequently, we confirmed that IPA promoted C2C12 cells" proliferation by activating MRF signaling. ipa 32-35 myelin regulatory factor Mus musculus 86-89 34684510-7 2021 LX-2 cells were used to study hepatoprotective effect of IPA in cells activated by TGF-beta1. ipa 57-60 transforming growth factor beta 1 Homo sapiens 83-92 34543641-9 2021 Akt inhibition using 10DEBC preserves IPA eNOS dimers. ipa 38-41 AKT serine/threonine kinase 1 Rattus norvegicus 0-3 34543641-9 2021 Akt inhibition using 10DEBC preserves IPA eNOS dimers. ipa 38-41 nitric oxide synthase 3 Rattus norvegicus 42-46 33955698-9 2021 The model provided a framework for predicting the effect on IPA of selatogrel followed by reversibly and irreversibly binding oral P2Y12 receptor antagonists for sustained effects. ipa 60-63 purinergic receptor P2Y12 Homo sapiens 131-136 35393392-6 2022 The activation of RIP1, RIP3, and MLKL and the upregulation of necrosome formation were increased upon iPA treatment while caspase-3, caspase-8, and PARP were not activated in GBM cells. ipa 103-106 receptor interacting serine/threonine kinase 1 Homo sapiens 18-22 35393392-6 2022 The activation of RIP1, RIP3, and MLKL and the upregulation of necrosome formation were increased upon iPA treatment while caspase-3, caspase-8, and PARP were not activated in GBM cells. ipa 103-106 myosin phosphatase Rho interacting protein Homo sapiens 24-28 35393392-6 2022 The activation of RIP1, RIP3, and MLKL and the upregulation of necrosome formation were increased upon iPA treatment while caspase-3, caspase-8, and PARP were not activated in GBM cells. ipa 103-106 mixed lineage kinase domain like pseudokinase Homo sapiens 34-38 35393392-7 2022 Co-treatment with specific necroptosis inhibitor necrostatin-1 (Nec-1) or Necrosulfonamide (NSA) prevented cell death caused by iPA treatment while the general caspase inhibitor Z-VAD-fluoromethylketone (z-VAD-fmk) did not elicit any effect, suggesting that this molecule induces caspase-independent necroptosis. ipa 128-131 caspase 8 Homo sapiens 280-287 34638872-8 2021 iPA reduces the vascular endothelial cadherin (VE-cadherin) expression levels in a dose-dependent manner, impairs the vasculogenic mimicry network by modulation of the Src/p120-catenin pathway and inhibition of RhoA-GTPase activity. ipa 0-3 cadherin 5 Homo sapiens 16-45 34638872-8 2021 iPA reduces the vascular endothelial cadherin (VE-cadherin) expression levels in a dose-dependent manner, impairs the vasculogenic mimicry network by modulation of the Src/p120-catenin pathway and inhibition of RhoA-GTPase activity. ipa 0-3 cadherin 5 Homo sapiens 47-58 34638872-8 2021 iPA reduces the vascular endothelial cadherin (VE-cadherin) expression levels in a dose-dependent manner, impairs the vasculogenic mimicry network by modulation of the Src/p120-catenin pathway and inhibition of RhoA-GTPase activity. ipa 0-3 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 168-171 34638872-8 2021 iPA reduces the vascular endothelial cadherin (VE-cadherin) expression levels in a dose-dependent manner, impairs the vasculogenic mimicry network by modulation of the Src/p120-catenin pathway and inhibition of RhoA-GTPase activity. ipa 0-3 catenin delta 1 Homo sapiens 172-184 35559231-3 2022 Corroborating our previous finding, we demonstrated that IPA and N6-BA affect GBM cell line proliferation by modulating the expression of the F-box WD repeat domain-containing-7 (FBXW7), a tumor suppressor with a crucial role in the turnover of many proteins, such as SREBPs and Mcl1, involved in malignant progression and chemoresistance. ipa 57-60 F-box and WD repeat domain containing 7 Homo sapiens 142-177 35559231-3 2022 Corroborating our previous finding, we demonstrated that IPA and N6-BA affect GBM cell line proliferation by modulating the expression of the F-box WD repeat domain-containing-7 (FBXW7), a tumor suppressor with a crucial role in the turnover of many proteins, such as SREBPs and Mcl1, involved in malignant progression and chemoresistance. ipa 57-60 F-box and WD repeat domain containing 7 Homo sapiens 179-184 35559231-3 2022 Corroborating our previous finding, we demonstrated that IPA and N6-BA affect GBM cell line proliferation by modulating the expression of the F-box WD repeat domain-containing-7 (FBXW7), a tumor suppressor with a crucial role in the turnover of many proteins, such as SREBPs and Mcl1, involved in malignant progression and chemoresistance. ipa 57-60 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 279-283 35621931-5 2022 In addition, IO and IPA supplementation regulated impaired protein synthesis (PI3K and Akt) or degradation (muscle-specific ubiquitin ligase muscle RING finger and atrogin-1) by modulating mRNA levels in gastrocnemius and soleus muscles. ipa 20-23 thymoma viral proto-oncogene 1 Mus musculus 87-90 35621931-5 2022 In addition, IO and IPA supplementation regulated impaired protein synthesis (PI3K and Akt) or degradation (muscle-specific ubiquitin ligase muscle RING finger and atrogin-1) by modulating mRNA levels in gastrocnemius and soleus muscles. ipa 20-23 ring finger protein 123 Mus musculus 124-140 35621931-5 2022 In addition, IO and IPA supplementation regulated impaired protein synthesis (PI3K and Akt) or degradation (muscle-specific ubiquitin ligase muscle RING finger and atrogin-1) by modulating mRNA levels in gastrocnemius and soleus muscles. ipa 20-23 F-box protein 32 Mus musculus 164-173 35621931-6 2022 Additionally, IO and IPA upregulated mRNA levels associated with muscle growth activation (transient receptor potential vanilloid type 4 and adenosine A1 receptor) or inhibition (myostatin and sirtuin 1) in gastrocnemius and soleus muscle tissues of Dexa-induced mice. ipa 21-24 adenosine A1 receptor Mus musculus 91-162 35621931-6 2022 Additionally, IO and IPA upregulated mRNA levels associated with muscle growth activation (transient receptor potential vanilloid type 4 and adenosine A1 receptor) or inhibition (myostatin and sirtuin 1) in gastrocnemius and soleus muscle tissues of Dexa-induced mice. ipa 21-24 sirtuin 1 Mus musculus 193-202 33356219-5 2021 Furthermore, IPA strengthened the mucus barrier by increasing mucins (MUC2 and MUC4) and goblet cell secretion products (TFF3 and RELMbeta). ipa 13-16 mucin 2, oligomeric mucus/gel-forming Homo sapiens 70-74 33904146-0 2021 Targeting HIF-1alpha by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression. ipa 66-69 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 10-20 33904146-7 2021 Anti-angiogenic efficacy of IPA (8k) validated through CAM, Rat corneal, tube formation and migration assay. ipa 28-31 calmodulin 1 Rattus norvegicus 55-58 33919052-4 2021 Melatonin and indole-3-propionic acid (IPA) are effective antioxidative indoles, each of which protects against KIO3-induced LPO in the thyroid. ipa 39-42 lactoperoxidase Homo sapiens 125-128 33356219-5 2021 Furthermore, IPA strengthened the mucus barrier by increasing mucins (MUC2 and MUC4) and goblet cell secretion products (TFF3 and RELMbeta). ipa 13-16 mucin 4, cell surface associated Homo sapiens 79-83 33356219-5 2021 Furthermore, IPA strengthened the mucus barrier by increasing mucins (MUC2 and MUC4) and goblet cell secretion products (TFF3 and RELMbeta). ipa 13-16 trefoil factor 3 Homo sapiens 121-125 33356219-5 2021 Furthermore, IPA strengthened the mucus barrier by increasing mucins (MUC2 and MUC4) and goblet cell secretion products (TFF3 and RELMbeta). ipa 13-16 resistin like beta Homo sapiens 130-138 32635392-3 2020 The biosynthetic pathway most frequently used in this synthesis is the conversion of tryptophan to indol-3-pyruvic acid (IPA) by tryptophan aminotransferase of Arabidopsis (TAA) followed by the conversion of IPA to IAA by enzymes encoded by YUCCA (YUC) genes of the flavin monooxygenase family; however, it is unclear whether YUC-mediated IAA biosynthesis is involved in SE induction. ipa 121-124 Flavin-binding monooxygenase family protein Arabidopsis thaliana 241-246 33447046-8 2020 IPA pre-treatment prevented the LPS-induced increase in MCP-1, IL-12, IL-13, and TNF-alpha levels 24 hours after pre-treatment, but had no effect on tryptophan metabolites. ipa 0-3 C-C motif chemokine ligand 2 Homo sapiens 56-61 33447046-8 2020 IPA pre-treatment prevented the LPS-induced increase in MCP-1, IL-12, IL-13, and TNF-alpha levels 24 hours after pre-treatment, but had no effect on tryptophan metabolites. ipa 0-3 interleukin 13 Homo sapiens 70-75 33447046-8 2020 IPA pre-treatment prevented the LPS-induced increase in MCP-1, IL-12, IL-13, and TNF-alpha levels 24 hours after pre-treatment, but had no effect on tryptophan metabolites. ipa 0-3 tumor necrosis factor Homo sapiens 81-90 32878262-7 2020 CHLE activates PPARalpha-dependent gene expression in Fao cells, an effect that is possibly mediated by IPA. ipa 104-107 peroxisome proliferator activated receptor alpha Rattus norvegicus 15-24 33023073-5 2020 Gene heatmaps for IPA canonical pathways showed a novel role for GSK-3 in GP6 signaling pathways associated with capacitation for 60 min. ipa 18-21 glycogen synthase kinase 3 beta Mus musculus 65-70 33023073-5 2020 Gene heatmaps for IPA canonical pathways showed a novel role for GSK-3 in GP6 signaling pathways associated with capacitation for 60 min. ipa 18-21 glycoprotein 6 (platelet) Mus musculus 74-77 32957728-5 2020 In addition, morphological changes and melanin content decreased in the alpha-MSH-induced zebrafish model after IPA and IOE treatment. ipa 112-115 STAM binding protein Mus musculus 72-81 31340190-5 2019 In addition, TRPM8 activation, by both a cooling compound icilin (82.1 +- 3.0%, n = 6) and cold temperature [thermal stimulus, basal tone (25 C, 41.2 +- 3.4%, n = 5) or pre-contracted tone induced by phenylephrine (25 C, 87.0 +- 3.6%, n = 7)], induced relaxation in IPA. ipa 268-271 transient receptor potential cation channel, subfamily M, member 8 Rattus norvegicus 13-18 31515268-11 2019 We also show that IPA more potently and specifically inhibits NSF/Sec18 activity than does N-ethylmaleimide (NEM), requiring the administration of only low muM concentrations of IPA, demonstrating that this compound could help to further elucidate SNARE-priming dynamics. ipa 18-21 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 62-65 31731426-6 2019 The level of glucose transporter 4 (GLUT4) in the muscles of HFD mice was stimulated by IPA intake. ipa 88-91 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 13-34 31731426-6 2019 The level of glucose transporter 4 (GLUT4) in the muscles of HFD mice was stimulated by IPA intake. ipa 88-91 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 36-41 31731426-7 2019 Our results suggested that IPA, which is a component of IO, can improve glucose homeostasis via GLUT4 in the muscles of HFD mice. ipa 27-30 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 96-101 31506421-4 2019 IPA induces the expression of tight junction proteins, such as ZO-1 and Occludin, and maintains intestinal epithelium homeostasis, leading to a reduction in plasma endotoxin levels. ipa 0-3 tight junction protein 1 Rattus norvegicus 63-67 31506421-4 2019 IPA induces the expression of tight junction proteins, such as ZO-1 and Occludin, and maintains intestinal epithelium homeostasis, leading to a reduction in plasma endotoxin levels. ipa 0-3 occludin Rattus norvegicus 72-80 31506421-5 2019 Interestingly, IPA inhibits NF-kappaB signaling and reduces the levels of proinflammatory cytokines, such as TNFalpha, IL-1beta, and IL-6, in response to endotoxin in macrophages to repress hepatic inflammation and liver injury. ipa 15-18 tumor necrosis factor Rattus norvegicus 109-117 31506421-5 2019 Interestingly, IPA inhibits NF-kappaB signaling and reduces the levels of proinflammatory cytokines, such as TNFalpha, IL-1beta, and IL-6, in response to endotoxin in macrophages to repress hepatic inflammation and liver injury. ipa 15-18 interleukin 1 alpha Rattus norvegicus 119-127 31506421-5 2019 Interestingly, IPA inhibits NF-kappaB signaling and reduces the levels of proinflammatory cytokines, such as TNFalpha, IL-1beta, and IL-6, in response to endotoxin in macrophages to repress hepatic inflammation and liver injury. ipa 15-18 interleukin 6 Rattus norvegicus 133-137 30322345-2 2019 We describe a novel technique for IPA repair that applies UGTI with thrombin foam (UGTFI). ipa 34-37 coagulation factor II, thrombin Homo sapiens 68-76 31108306-10 2019 Use of IPA and Cytoscape showed that the oxygen species metabolic process glycolysis I/gluconeogenesis I, accompanied by downregulation of tubulin beta 3 class III (TUBB3), RAC-alpha serine/threonine-protein kinase (AKT1), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), was the most significantly affected pathway in the NOD group. ipa 7-10 AKT serine/threonine kinase 1 Homo sapiens 216-220 31108306-10 2019 Use of IPA and Cytoscape showed that the oxygen species metabolic process glycolysis I/gluconeogenesis I, accompanied by downregulation of tubulin beta 3 class III (TUBB3), RAC-alpha serine/threonine-protein kinase (AKT1), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), was the most significantly affected pathway in the NOD group. ipa 7-10 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 227-267 31108306-10 2019 Use of IPA and Cytoscape showed that the oxygen species metabolic process glycolysis I/gluconeogenesis I, accompanied by downregulation of tubulin beta 3 class III (TUBB3), RAC-alpha serine/threonine-protein kinase (AKT1), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), was the most significantly affected pathway in the NOD group. ipa 7-10 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 269-274 31211619-2 2019 One such metabolite, indole 3-propionic acid (IPA), can activate the pregnane X receptor(PXR), a xenobiotic-activated nuclear receptor present in many tissues, including the vascular endothelium. ipa 46-49 nuclear receptor subfamily 1, group I, member 2 Mus musculus 69-88 31211619-2 2019 One such metabolite, indole 3-propionic acid (IPA), can activate the pregnane X receptor(PXR), a xenobiotic-activated nuclear receptor present in many tissues, including the vascular endothelium. ipa 46-49 nuclear receptor subfamily 1, group I, member 2 Mus musculus 89-92 31186357-4 2019 To overcome these limitations, here we develop an alternative synthetic pathway termed the isoprenoid alcohol (IPA) pathway that centers around the synthesis and subsequent phosphorylation of IPAs. ipa 111-114 hypoxia inducible factor 3 subunit alpha Homo sapiens 192-196 30322345-6 2019 CONCLUSIONS: Treatment of IPA with UGTFI may reduce the embolization rate, risk of IPA cavity thrombin leakage, required drug dose. ipa 26-29 coagulation factor II, thrombin Homo sapiens 94-102 30521325-7 2019 The selected ensemble revealed IPA317 in a transient cavity of the cytochrome b, interacting directly with the residue T313, which is the site of spontaneous mutation conferring resistance to the IPA series. ipa 31-34 mitochondrially encoded cytochrome b Homo sapiens 67-79 30078218-9 2018 IPA analysis showed that canonical pathways, such as FXR/RXR activation, adipogenesis pathway, and LXR/RXR activation, were involved in regulating osteogenic differentiation of ASCs. ipa 0-3 nuclear receptor subfamily 1 group H member 4 Homo sapiens 53-56 30078218-9 2018 IPA analysis showed that canonical pathways, such as FXR/RXR activation, adipogenesis pathway, and LXR/RXR activation, were involved in regulating osteogenic differentiation of ASCs. ipa 0-3 retinoid X receptor alpha Homo sapiens 57-60 30078218-9 2018 IPA analysis showed that canonical pathways, such as FXR/RXR activation, adipogenesis pathway, and LXR/RXR activation, were involved in regulating osteogenic differentiation of ASCs. ipa 0-3 retinoid X receptor alpha Homo sapiens 103-106 28782205-10 2018 In T84 cells, IPA reversed the IFN-gamma induced increase of fructose transporter SLC2A5 (GLUT5) mRNA, but not induction of inflammatory or metabolic genes. ipa 14-17 solute carrier family 2 member 5 Homo sapiens 90-95 29531855-7 2018 IPA predicted, and RT-PCR and flow cytometry confirmed, that the PI3K/AKT pathway was activated following short-term hypoxia. ipa 0-3 AKT serine/threonine kinase 1 Homo sapiens 70-73 29150624-6 2017 For IPA detection in 79 pure or heterogeneous GGNs, the heterogeneous GGN sign was the most useful finding, with most specificity (sensitivity, 66.7%; specificity, 79.1%), followed by CT attenuation (HU) of -493 (sensitivity, 75%; specificity, 74.6%) and a lesion size 10 mm (sensitivity, 83.3%; specificity, 70.1%). ipa 4-7 gametogenetin Homo sapiens 46-49 29238104-4 2017 We determined whether IPA suppresses IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 in proximal tubular cells. ipa 22-25 aryl-hydrocarbon receptor Mus musculus 62-65 29110801-12 2017 P2X1 or P2Y1 receptor antagonism during NANC relaxation increased distal IPA relaxation but decreased proximal IPA relaxation. ipa 73-76 purinergic receptor P2X 1 Homo sapiens 0-4 29110801-12 2017 P2X1 or P2Y1 receptor antagonism during NANC relaxation increased distal IPA relaxation but decreased proximal IPA relaxation. ipa 73-76 purinergic receptor P2Y1 Homo sapiens 8-21 29110801-12 2017 P2X1 or P2Y1 receptor antagonism during NANC relaxation increased distal IPA relaxation but decreased proximal IPA relaxation. ipa 111-114 purinergic receptor P2X 1 Homo sapiens 0-4 29110801-12 2017 P2X1 or P2Y1 receptor antagonism during NANC relaxation increased distal IPA relaxation but decreased proximal IPA relaxation. ipa 111-114 purinergic receptor P2Y1 Homo sapiens 8-21 29238104-7 2017 Furthermore, the effects of IPA on IS-induced expression and phosphorylation of signal transducer and activator of transcription 3 (Stat3) were studied in HK-2 cells. ipa 28-31 signal transducer and activator of transcription 3 Mus musculus 80-130 29238104-7 2017 Furthermore, the effects of IPA on IS-induced expression and phosphorylation of signal transducer and activator of transcription 3 (Stat3) were studied in HK-2 cells. ipa 28-31 signal transducer and activator of transcription 3 Mus musculus 132-137 29238104-9 2017 IPA significantly suppressed IS-induced mRNA and protein expression of AHR, CYP1A1, TGF-beta1, and MCP-1 in HK-2 cells. ipa 0-3 aryl hydrocarbon receptor Homo sapiens 71-74 29238104-9 2017 IPA significantly suppressed IS-induced mRNA and protein expression of AHR, CYP1A1, TGF-beta1, and MCP-1 in HK-2 cells. ipa 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 76-82 29238104-9 2017 IPA significantly suppressed IS-induced mRNA and protein expression of AHR, CYP1A1, TGF-beta1, and MCP-1 in HK-2 cells. ipa 0-3 transforming growth factor beta 1 Homo sapiens 84-93 29238104-4 2017 We determined whether IPA suppresses IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 in proximal tubular cells. ipa 22-25 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 67-73 29238104-9 2017 IPA significantly suppressed IS-induced mRNA and protein expression of AHR, CYP1A1, TGF-beta1, and MCP-1 in HK-2 cells. ipa 0-3 chemokine (C-C motif) ligand 2 Mus musculus 99-104 29238104-10 2017 IPA suppressed the IS-induced expression and phosphorylation of Stat3 in HK-2 cells. ipa 0-3 signal transducer and activator of transcription 3 Mus musculus 64-69 29238104-12 2017 In conclusion, IPA suppressed the IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 through suppression of Stat3 in proximal tubular cells. ipa 15-18 aryl-hydrocarbon receptor Mus musculus 59-62 29238104-12 2017 In conclusion, IPA suppressed the IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 through suppression of Stat3 in proximal tubular cells. ipa 15-18 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 64-70 29238104-4 2017 We determined whether IPA suppresses IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 in proximal tubular cells. ipa 22-25 transforming growth factor, beta 1 Mus musculus 75-84 29238104-12 2017 In conclusion, IPA suppressed the IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 through suppression of Stat3 in proximal tubular cells. ipa 15-18 transforming growth factor, beta 1 Mus musculus 72-81 29238104-4 2017 We determined whether IPA suppresses IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 in proximal tubular cells. ipa 22-25 chemokine (C-C motif) ligand 2 Mus musculus 90-95 29238104-12 2017 In conclusion, IPA suppressed the IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 through suppression of Stat3 in proximal tubular cells. ipa 15-18 chemokine (C-C motif) ligand 2 Mus musculus 87-92 29238104-12 2017 In conclusion, IPA suppressed the IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 through suppression of Stat3 in proximal tubular cells. ipa 15-18 signal transducer and activator of transcription 3 Mus musculus 116-121 29238104-6 2017 The effects of IPA on IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 were studied using proximal tubular cells (HK-2). ipa 15-18 aryl-hydrocarbon receptor Mus musculus 47-50 28498421-7 2017 Subsequently, IPA was used to search for molecules that are regulated by Hnf4alpha, and exist in the PFC and serum. ipa 14-17 hepatic nuclear factor 4, alpha Mus musculus 73-82 28677729-13 2017 In-depth IPA analysis revealed that CENPU was associated with the HMGB1 signaling pathway. ipa 9-12 centromere protein U Homo sapiens 36-41 28677729-13 2017 In-depth IPA analysis revealed that CENPU was associated with the HMGB1 signaling pathway. ipa 9-12 high mobility group box 1 Homo sapiens 66-71 27993680-5 2017 The recombinant PTK6 kinase domain was purified and co-crystallized at room temperature by the sitting-drop vapor diffusion method, collected X-ray diffraction data at in-house and resolved co-crystal structure of PTK6-KD with Dasatinib at 2.24 A and with IPA compound at 1.70 A resolution. ipa 256-259 protein tyrosine kinase 6 Homo sapiens 16-20 27993680-5 2017 The recombinant PTK6 kinase domain was purified and co-crystallized at room temperature by the sitting-drop vapor diffusion method, collected X-ray diffraction data at in-house and resolved co-crystal structure of PTK6-KD with Dasatinib at 2.24 A and with IPA compound at 1.70 A resolution. ipa 256-259 protein tyrosine kinase 6 Homo sapiens 214-218 27993680-3 2017 Novel imidazo[1,2-a]pyrazin-8-amines (IPA) derivative compounds and FDA approved drug, Dasatinib are reported to inhibit PTK6 kinase activity with IC50 in nM range. ipa 38-41 protein tyrosine kinase 6 Homo sapiens 121-125 27863550-5 2016 Dogs with IPA had significantly higher concentrations of CCL2 (3316+-2452pg/ml, mean+-SD) and CXCL8 (3668+-3879pg/ml) compared with the healthy controls (235+-45pg/ml and <15.6pg/ml, respectively). ipa 10-13 C-C motif chemokine ligand 2 Canis lupus familiaris 57-61 27911093-8 2017 IPA revealed that Nrf2-mediated pathway, together with glutamate metabolism, is the common significantly modulated pathway across treatments. ipa 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 27863550-5 2016 Dogs with IPA had significantly higher concentrations of CCL2 (3316+-2452pg/ml, mean+-SD) and CXCL8 (3668+-3879pg/ml) compared with the healthy controls (235+-45pg/ml and <15.6pg/ml, respectively). ipa 10-13 C-X-C motif chemokine ligand 8 Canis lupus familiaris 94-99 27881846-4 2016 Naturally occurring IPA has the potential to initiate a potent IFN-alpha response early in the course of HIV mucosal invasion in time to terminate infection prior to the creation of a pool of persistently infected cells. ipa 20-23 interferon alpha 1 Homo sapiens 63-72 26902805-4 2016 Meanwhile, dogs with IPA exhibited significantly higher activity of pro- and active MMP-9 than other groups. ipa 21-24 matrix metallopeptidase 9 Canis lupus familiaris 84-89 27528061-15 2016 In conclusion, Rho kinase activation, via NOX1-derived ROS and downregulation of Nrf2 system, impairs IPA function in DM. ipa 102-105 Rho-associated coiled-coil containing protein kinase 2 Mus musculus 15-25 27528061-15 2016 In conclusion, Rho kinase activation, via NOX1-derived ROS and downregulation of Nrf2 system, impairs IPA function in DM. ipa 102-105 NADPH oxidase 1 Mus musculus 42-46 27528061-15 2016 In conclusion, Rho kinase activation, via NOX1-derived ROS and downregulation of Nrf2 system, impairs IPA function in DM. ipa 102-105 nuclear factor, erythroid derived 2, like 2 Mus musculus 81-85 27580007-4 2016 The present study was designed to investigate the effects of IPA on TGF-beta/Smad signaling in vivo, using a hypoxia-induced pulmonary hypertension (PH) rat model. ipa 61-64 transforming growth factor, beta 1 Rattus norvegicus 68-76 27580007-12 2016 Our data indicated that IPA attenuated PH, RV hypertrophy and pulmonary vascular remodeling in rats, which was probably mediated by restraining the hypoxia-induced overactive TGF-beta1/Smad signaling. ipa 24-27 transforming growth factor, beta 1 Rattus norvegicus 175-184 27580007-13 2016 In conclusion, IPA is a promising protective treatment in PH due to the inhibiting effects on TGF-beta1/Smad 2/3 signaling. ipa 15-18 transforming growth factor, beta 1 Rattus norvegicus 94-103 25124890-10 2015 IPA revealed cytotoxic T-lymphocyte antigen 4 (CTLA4) signaling was the most significant pathway present in the peripheral whole blood of stroke patients 24-48 hr after onset. ipa 0-3 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 13-45 27688749-13 2016 IPA mapped the above-mentioned hypermethylated genes to the Wnt/beta-catenin, PI3k/AKT, VEGF, and JAK/STAT3 signaling pathways. ipa 0-3 catenin beta 1 Homo sapiens 64-76 27688749-13 2016 IPA mapped the above-mentioned hypermethylated genes to the Wnt/beta-catenin, PI3k/AKT, VEGF, and JAK/STAT3 signaling pathways. ipa 0-3 AKT serine/threonine kinase 1 Homo sapiens 83-86 27688749-13 2016 IPA mapped the above-mentioned hypermethylated genes to the Wnt/beta-catenin, PI3k/AKT, VEGF, and JAK/STAT3 signaling pathways. ipa 0-3 vascular endothelial growth factor A Homo sapiens 88-92 27688749-13 2016 IPA mapped the above-mentioned hypermethylated genes to the Wnt/beta-catenin, PI3k/AKT, VEGF, and JAK/STAT3 signaling pathways. ipa 0-3 signal transducer and activator of transcription 3 Homo sapiens 102-107 25728835-6 2015 IPA implicated, most prominently, 14-3-3 and aryl hydrocarbon receptor signaling in schizophrenia, and gluconeogenesis/glycolysis in bipolar disorder. ipa 0-3 aryl hydrocarbon receptor Homo sapiens 45-70 25124890-10 2015 IPA revealed cytotoxic T-lymphocyte antigen 4 (CTLA4) signaling was the most significant pathway present in the peripheral whole blood of stroke patients 24-48 hr after onset. ipa 0-3 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 47-52 24214141-4 2014 During maintenance doses of clopidogrel, IPA values of only CYP2C19 PM subjects were gradually decreased from 30.0 +- 21.9% on day 2 to 23.7 +- 16.6% on day 8 (P > .05 for time effect; P < .05 for time and genotype interaction effect). ipa 41-44 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 60-67 25065623-3 2014 Indole 3-propionic acid (IPA), in the context of indole, is a ligand for PXR in vivo, and IPA downregulated enterocyte TNF-alpha while it upregulated junctional protein-coding mRNAs. ipa 25-28 nuclear receptor subfamily 1, group I, member 2 Mus musculus 73-76 25065623-3 2014 Indole 3-propionic acid (IPA), in the context of indole, is a ligand for PXR in vivo, and IPA downregulated enterocyte TNF-alpha while it upregulated junctional protein-coding mRNAs. ipa 25-28 tumor necrosis factor Mus musculus 119-128 25065623-3 2014 Indole 3-propionic acid (IPA), in the context of indole, is a ligand for PXR in vivo, and IPA downregulated enterocyte TNF-alpha while it upregulated junctional protein-coding mRNAs. ipa 90-93 tumor necrosis factor Mus musculus 119-128 25125592-9 2015 IPA also predicted activation of STAT1, STAT2 and STAT3 transcription factors in RA neutrophils (P < 0.01), which was confirmed by western blotting. ipa 0-3 signal transducer and activator of transcription 1 Homo sapiens 33-38 25125592-9 2015 IPA also predicted activation of STAT1, STAT2 and STAT3 transcription factors in RA neutrophils (P < 0.01), which was confirmed by western blotting. ipa 0-3 signal transducer and activator of transcription 2 Homo sapiens 40-45 25125592-9 2015 IPA also predicted activation of STAT1, STAT2 and STAT3 transcription factors in RA neutrophils (P < 0.01), which was confirmed by western blotting. ipa 0-3 signal transducer and activator of transcription 3 Homo sapiens 50-55 22757692-6 2013 IPA indicated a common integrative signaling node, calcineurin B1 (CANB1, CaNBalpha, or PPP3R1), which was downregulated by TBI. ipa 0-3 protein phosphatase 3, regulatory subunit B, alpha Rattus norvegicus 88-94 23613909-6 2013 Through HPLC and LC-MS analysis of reaction products in vitro by testing eight substrates including auxins and other compounds, we found that UGT74D1 had a strong glucosylating activity toward indole-3-butyric acid [IBA], indole-3-propionic acid [IPA], indole-3-acetic acid [IAA] and naphthaleneacetic acid [NAA], catalyzing them to form corresponding glucose esters. ipa 247-250 UDP-glucosyl transferase 74D1 Arabidopsis thaliana 142-149 22666341-11 2012 Additionally, using IPA together with ectopic expression of p53, we show p53 as an upstream regulator of Bcl-2 in Cr(VI)-transformed cells. ipa 20-23 tumor protein p53 Homo sapiens 73-76